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<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSB6</accession>
    <name>A0A8G1QSB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">feruloyl esterase</fullName>
            <ecNumber evidence="1">3.1.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ferulic acid esterase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_431125</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AB hydrolase superfamily. FaeA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="1"/>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510641.1">
        <property type="nucleotide sequence ID" value="XM_025658322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSB6"/>
    <dbReference type="GeneID" id="37161724"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005592">
        <property type="entry name" value="Mono/diacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03893">
        <property type="entry name" value="Lipase3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034212228" description="feruloyl esterase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Mono-/di-acylglycerol lipase N-terminal" evidence="11">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="10">
        <location>
            <begin position="105"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH52719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="307" mass="33762" checksum="389D4048BD095128" modified="2022-01-19" version="1">MRLLKSLLVAASAIAGCNALPGGALHKRDITTQQLDTFTFWVQYAAASYCEPNYAGKAGHKITCSAQNCPAVEASNATIITDFSNTTPTDTSGYLAVDHTHRAIVLAFRGSYSIRSWLADFTFIYTDPNLCSGCEAELGFWSSWTNVRKTLTPTLNNTVSQYPDYELVIVGHSLGAAIATLAAADIRETDGLNATLYAYASPRVANPKLAEFITNQNKGANYRFAHTDDPVPRVPLEVMGYKHISPEYWISSGNNQSVSTQDVVVFQDGDDKRGDVGFPNLLHFEAHLWYFEKWEVDACKGEGLPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSN6</accession>
    <name>A0A8G1QSN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_507955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510123.1">
        <property type="nucleotide sequence ID" value="XM_025664430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSN6"/>
    <dbReference type="GeneID" id="37167832"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="276"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="646" mass="73051" checksum="C0CC0C937F81DE93" modified="2022-01-19" version="1">MTKPRDRPKSGRPKRRPLGSSGPRSLPARDNSLRESISSSSTARTAPRAETQFFGSTAFPAIISDDQNVVGRYLGQLSAQEFSSGPGCPNYQEKYTEKQISEGTKVLNLLFEFPGFADSICRYLELSYTCMVPHPFIKACIESIQETMQRFKGNRLKQLVVTLFANTAKPLDAFTTLPAEDYHTLFTGPNIRWEIIGFILAILGVSLKYDVNKRSKPSETSQSDQKPDFIHRLAEGVDYCTAVCNNYNCVSPQALWLLYGNACLKNLVYGDMSFQLWRCMGDVSSMFFALGLHQEESGLEATYPFYQVELRRRYAAQIYSMDKTISTFLGRPPRISGSYCASTMPADIDDEILLLEGDELDNALRAVDANGWNMDREFRGATWRRIKLIISQFREEILGLCLGTRLSIGNEALARDILARQEAVWDQIPQELKYDETTGSQHIPPPQRYVVMTTYMDQKYTCFLLHRKLLNETQWTREPLYRISRSLLNTVLQVVSLSDQVSNMQRDISWPMLYYGLPGASILAVDLLKHLHPSFNTSNPEIKVIPRAEVIQNLAVFVSNLQRSINRREVNGESCRRAHGILSRILDEIIDPTNGQLAVLDLEVQQMPNSTPFPFTSGIDSDLNIDNFFSQIGNWDLALDTSAIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QU26</accession>
    <name>A0A8G1QU26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_472589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510511.1">
        <property type="nucleotide sequence ID" value="XM_025662566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QU26"/>
    <dbReference type="GeneID" id="37165968"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="236" mass="25811" checksum="8A46ECB175C520EC" modified="2022-01-19" version="1">MSLDKNSSTASMSRKDDTRIHTDNLWVSHATVGSGLGAVDASGILSIHIPRMKITSPSHSRPFFLETRWHCPLPSRLGLVDLLPDHPRSTVNEIDGPLPVVWKAADQGELWNFARPVILTGADSSQLTCWSHGKSIATSLGADQLRSNHDTLGMEHSEKQNAAKVHPYLPDFFEPKAGMPVRYRAPSLQRVVEFVEVGHGVDGFFPGGFLCPRTHFLRHLSTGLGLLPALAGQSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUH5</accession>
    <name>A0A8G1QUH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_453476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511004.1">
        <property type="nucleotide sequence ID" value="XM_025661064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUH5"/>
    <dbReference type="GeneID" id="37164466"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="461" mass="52257" checksum="F98522E10C4CBC25" modified="2022-01-19" version="1">MPSSQDTLSPLVSDKAIHHEEHETSDLPPSRVTFVRQRRKLRLISPAWYRNSLLASVGFLEFANAGDFAANVWNDVPVPLYAVIFMAIGGPLALLISVAALWDGILSWRNVRILQQERQYLHALRLQYLNLPPSVPVDQASVRLIDRRLGVSFRELGSELIDRVVMDVFLGIGALLVGTGTIMAIWGAHRHVYYISNLLSGFVGNSFAAAYGVLNAVWSLYLIWRFYGHDRACTRSSAITPFRGRLHRRFQYFQLHSLVSGITGLVAGAASMLTCKRWWGYVMLIPCMIFEVGCNQFWRVQLGYDRPIVTEQPHWGLIPDFKASKEDDEEKDSVLLDTLASVIAMQNALTPHPTAMIDVDWSSLDSLLSFIVHNHLFDSLCGWLATHSSVPKDFHHNLFRLCADYTEITLTLADLRSLPEIEHPRLLDLVRDFLYTEGQQVMIGRERYLLEMVGYTAWKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUK1</accession>
    <name>A0A8G1QUK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein FYV10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein fyv10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_471575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511841.1">
        <property type="nucleotide sequence ID" value="XM_025662481.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37165883"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="6">
        <location>
            <begin position="218"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="7">
        <location>
            <begin position="496"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1060"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1203"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1331"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="776"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="973"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1088"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1121"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1144"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1331"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1366"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1437"/>
            <end position="1448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH53919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1466" mass="160944" checksum="50C14123925AADE8" modified="2022-01-19" version="1">MTDASFPPSGGAPRAAAALTTSTTTASTTATSSSSTPSTYNYYSNVPSISSIPRRSSYASVLSGTAALSPPTFSNHPFSPFSPSLSTSTASYPPPPPFSSDARLLRPSAAVDAEMQMNSSWRSSPGDSLPPYSRKFANLARFDPCYHNPGAFTDSPTPSFTPSYLQNSRYVSRLDAARRAKLAAQRDGAIPSSASNNLSTSSSQASLPRIAPSHRGMTYDIIEREPPSDDDHLLPLPSRWSDDDKFTGLELGNGGLEVRYTGPVNKHEHEAAAVRADNPMPPQCGIYYFEITILSKPKEGMIGIGFSSKKASVERLPGWEQESWAYHGDDGKSFFGESQGQGRQYGPTFGANDTVGCGVNFSTGCAFFTKNGVFLGNAFRELRNLKVYPSVGMKKQPPVHLVVNFGQQPFMFDIDDMVKKEKSLIHSKIALTSTANLQPPLDESGLLQELVAQFLAHDGYVETARAFAEEVAAESTALENGRQAPLKKYEVEEDVEAINRQKIRAAILEGDIDKALKYTNAYYANVLQTYPQIHFKLRCRKFLEMMRRCNESSPSPSKRGKSSNGLSDSSAVFDQEMELDEQLQEGDGYEADGMDMEETESTARSNELLTEAVQYGQQLFLDYPPEERGGDRKMLDDIFSLVAYQDARRSVHGHYLDPAGRIAVAEELNSAILAVSLGKSSSAALERLYQQTEVLVNEISEEGGAGAFINVPANHLPCIPSHAATSSSSAFPRCCCGRDDCAFLLHNHVALEGLEKDLATAARLGQALLHRHESYMAEAEEDRHRLLVSIENLEREKREVQAENARIVEDNRGLLEQLDGLNKAVAESDSHSKSLETRLESTEAELRKLTHSAARAADLEAQLAQMEAEQSKLQESLQSAQEDSKSAVQRWRQAECTLRDLHDQVDRIEKEARKERDRHAELVQRMERRRTVERELDGAAGRLKGAAAAQDLGRNRGGATVVSRFVRDILQDNANLQMGIMELREMLESSNQEVENLRDQVLSHQPLGPEDQEIRPSTTLSQELESKESRRVSQEFHIHHHYHSPAIKKERGSLFRRNKKRRSLGSATVLHSAAGTPLPHRPNHRSKPSTSSASTILSQTSVSIPPTVPHRWSVQSPATESMASSPQSAYQPSSIFDRVDRGFDSSQPTSPDSTVFSSPLRNGRFKKAQIDAAYRSLDGDGVSIPGIDDELVHDYFQRRSSAEYAGRAPMQSVIPEEREDGRSTNYPESERAASPAVQEGMFSTPYRGPRRSASHESLFSVAGMDIHTPSRRPSRLSDLHSSAVPVRIPRRIMSSRADLFPTPPVISPSIVTAGSELAMITDQSPQTLLASVAGSRSQTPVENDPEDTTTSSRKFSLGRRVGGWVRGHWGTAPTSSNESNAETSATASAPTSNTPSRRPSSAGSASRKSRHHRPQLAPPLRFRYPGVNQKGPILGFRPPSRSRVPVSVHAEQVDEGLLRESLADCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUQ1</accession>
    <name>A0A8G1QUQ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_382659</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510871.1">
        <property type="nucleotide sequence ID" value="XM_025656477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUQ1"/>
    <dbReference type="GeneID" id="37159879"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH52949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="348" mass="39357" checksum="75EA1F1C1ED7E977" modified="2022-01-19" version="1">MFWGKHHDDTPEAAQQQPIPRKKLPSHLQKLADNDDSFYDDIYSSYSVDSTETPYRYAGYANRLRTVLLSAHRYVAYTSDIGESFRPVAHPWLVRSAYGISWTYLIGDVAHEGYKAYLRNRRVLAPPCEAYKDASDLTHEQVAKGMVTGNIAGSLTGSSSSSDTLMPWPTTHVPLAEDYRTVMAQRAVFQGIASMGLPAFTIHSVVKYSGRMLKNSRSVFFRTWAPIGLGLSVVPFLPYLFDKPVEEAVEWAFHTGLRAYAGEDAVRPLPQAVRTPHDEETSLSHFLRAQAEKNNGEVMGYDANVSWEKYKEERRRAKEQRMQEREQRGERGPLALLGFGSNSKEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUT3</accession>
    <name>A0A8G1QUT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_199765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510527.1">
        <property type="nucleotide sequence ID" value="XM_025654516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUT3"/>
    <dbReference type="GeneID" id="37157918"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="114"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH52605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="585" mass="63553" checksum="24B0F19EE6E599DA" modified="2022-01-19" version="1">MPFGVNPFRKNDHDFPGVVVPLSEAPPHHKPNPELEKTDRPDEKTDNRSLDRAPSSEAGVGSVHNYNTLTIEALRAEVEADIATSGKDTAYDRKAKLINRAIQDIGMGRYQWQLFALCGFGWLADNLWLQGVALTLTPIASEFGVSTTWVRFTTCSLFLGLCIGASFWGIASDIIGRRPAFNMTLFICGVFGIAAGGAPTWIGACALYACLGLGVGGNLPVDGALFLEFLPFASGNLLTMLSVWWPLGQLVSSLLAWAFIPNYSCSSDLPACGNVASGEACCTKQSNMGWRYLCFTLGALTFVMFICRFFLFHLYESPKYLLARGRQSDAVASVHGIAHKNRTKTWLTEEILNEIGGYPEEVAEEKLSFAEIVRRNLSKFSLERIGPLFSSKKLGFSTVLLWFCWATIGMGYPLFNAFLPQYLERAGGSSSSSTYIAYRNYAITSIVGVPGSILACYTVEIKYVGRKGTMVISTLITGVLLFCFTASTDSNIQLLCSCLEAFFQNIMYGVLYAYTPEVFPAPNRGTATGISSCLNRIAGLCAPLVAIYGASSNPDAPIYASGGLILAAFVAMCLLPIETRGKQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUT6</accession>
    <name>A0A8G1QUT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_453164</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511293.1">
        <property type="nucleotide sequence ID" value="XM_025660997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUT6"/>
    <dbReference type="GeneID" id="37164399"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF881">
        <property type="entry name" value="FI07970P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="202"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH53371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="353" mass="39716" checksum="0969D7B432CBA50D" modified="2022-01-19" version="1">MSVTNASPGNFDHIPIIDLSALRSPVLKERQQLAKEIFTACTQVGFFYIKNHGIAEDVITSLHDMARQFFTLSQKQKMDYYIGRSRKFRGFMPLYSEQPTDTDLGSAPKPDPTSPGAFSESFDIGYEVAADPLKSQHDALPPDTYDLYGDNQWPEEDVLPGFREVYLRYFAEAMTLSRALIRIFALALDLPEDFFDPMVKNPGATSRMLHYPPQPVAGEVKVGLGEHTDYECFTILSQDRVPALQVLNARQEWILAPPIPGTLVVNISDCLSIWTNKKFKSTIHRVTNLTGQERYTIPFFFGVDYDTTVAVLPSCITEDSPACKKPFKAGEWVRHQLTTAYVGYEPEPPTQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVC2</accession>
    <name>A0A8G1QVC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Class I SAM-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_429267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511454.1">
        <property type="nucleotide sequence ID" value="XM_025658244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVC2"/>
    <dbReference type="GeneID" id="37161646"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31919" checksum="740FE917F43FC315" modified="2022-01-19" version="1">MSFLPRLHLFEIADQPWCPHKAIEYAQLCLTHCWNLRLPPVAKVSSAVVACEVLADNFPDLSSFTFVDLGSGAGGPSATFEKLLNARLRAQHLPPAQFLLTDLNPHPREWAALTKQQENISYISEPVDASKCGRLVPQNRKECRMFNIAFHHFDDPLAVPMLRSAIESADAFIIFELTARDLSSMLILPGLILIACQYTLLRFWRSPLHLIFTFVLPLAPLLMVFDGFVSIMRCRTSDELHDLVRRTDAPGLENWEFRSGKSPVMYPTTNVHWFMGVKKTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVS4</accession>
    <name>A0A8G1QVS4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_462212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512465.1">
        <property type="nucleotide sequence ID" value="XM_025661833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVS4"/>
    <dbReference type="GeneID" id="37165235"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="101" mass="10567" checksum="BD3EA5F5F9085A50" modified="2022-01-19" version="1">MQWQARKAGNAVDVSHGLHLANACRLGSASIGARPGSITNEAAEVAVWLTAVTRLACDGEGDLHAPSNPLRNETKRGIWPPVGGWLNTSVLEGRSVEAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVS7</accession>
    <name>A0A8G1QVS7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_82335</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513223.1">
        <property type="nucleotide sequence ID" value="XM_025665706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVS7"/>
    <dbReference type="GeneID" id="37169108"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="41"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH55301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="375" mass="41968" checksum="D04F937184D47FBA" modified="2022-01-19" version="1">MANNTSAMDALLSNHSRENRGPEVLAACIISMFFCVLATVVRLVAQATIRRLFTPDSILIIFASILALAVSSCTIAAVKNGLGRHEYWVMKEDPHPPERTAFIFEMGYVVTVLQAAALMFNKLSILFFYQRAFTSIIRSLRYTIWALFVFCTGLGVGSTVAFICACVPPQMFWLRVYPIFGFEPPEPLHGHCEPQRLHLGVPLLLDLFSEVVMLLVPVFVLWNLQMPCRKKAAVIFTFSLGAFVTAISAVRFYYSWKLENGGDLSWDDTDSYMWNSVQLCWGVVTACIPASAPLLRVVQKSTTVSKSRRPFKPHGYMMSTNGRVAQGKGQRHAQRLDSVTELTNSSWDEGESGPWTNSADPSLELEEGRRNKHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVY6</accession>
    <name>A0A8G1QVY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_149018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511908.1">
        <property type="nucleotide sequence ID" value="XM_025654135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVY6"/>
    <dbReference type="GeneID" id="37157537"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH53986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="447" mass="48841" checksum="95C144632747F58C" modified="2022-01-19" version="1">MTDNSSVEAYPEAITEFDEKTINNETIKEKKWGILSKSQSVASWKDPGPPPDGGALAWTQVLVGHLIIMNTWGYMNSFGIFQTYYVDFLNRSDSDVSWIGSVQVFIVFFIGTFTGRFTDAGYFRPVFVVGTILSVLGMFMASISTEYYQIFLAQGICCGIGNGCLFCPALSVTSTYFAKRKMLAVGICACGSATGGLIFTVMFQHLIPQIGYGWTMRVFGFFTLACLIICNILARPRVPPRKTGPLIELAAFKEPSYTLFAVGIFLTFWGVYFAFYYLSSFGVAIINISQEESLTFTLILNGLGIIGRPLPAYLADRYTGPMNILLVVTLFSIICAFAMIGVTSISGLYAWTVVYGIVGNGLQGMFPATLSSLTTDLQKAGVRMGMIFTIVSFAVLTGPPIAGVLITRDNGRYVYAQLFAACSMLIGFCLLCAARLAKTGKVLKYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWI5</accession>
    <name>A0A8G1QWI5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_523132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512223.1">
        <property type="nucleotide sequence ID" value="XM_025665322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWI5"/>
    <dbReference type="GeneID" id="37168724"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH54301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="123" mass="13956" checksum="E0EA275BD824CA09" modified="2022-01-19" version="1">MADAQKQMQALTEEFQALQTELDGLVEARQKLESQQQENVGVQKEFNSLDDESNIYKLIGPVLLKQEKSEALMAVNGRLEFIEKEIKRIEGQIQENQDKSDKKRTEIVQFQTQMQQAAAAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWP9</accession>
    <name>A0A8G1QWP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS quinate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_523556</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511487.1">
        <property type="nucleotide sequence ID" value="XM_025665359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWP9"/>
    <dbReference type="GeneID" id="37168761"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000313">
        <property type="entry name" value="MFS quinate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="30"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="524"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH53565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="553" mass="60333" checksum="1F58A016F7D5F124" modified="2022-01-19" version="1">MAGSKKPVNIFRLRNLADPKEVFNWRLWFAVLSFGLMGAARGVDEGLISGAFNSKDFQRTIHLDSYSEVEQTNIKANVSAMVQIGSVGGALFAFLVCDRIGRLWATRQLCVLWILGIAIFMGVGANGSLGAVYAGRFVAGLGVGQTVVVGPVYLAEIAPASVRGLCTCVFTGFVYLGIVLAYFTNYGCQLHMGDHTHKRWEVPTSLHIMFAGLIFLLSFVQYESPRFLVKKGKPEEALNNLARLRNLPPDHEYVVEEFTGIQNAHQAEMEATMGAGWLGIVKEAIMVPSNLYRLYLAAMAQLLSQWSGAGSITLYAPDLFSLLGITGSNESLLVTAVFGIVKLTAAVICALFLVDVIGRKRALLLGITLQAISMIYVASFLTSVPEMGIVDDFVLPESKRGSSRGAIAMIYISGVGWALGWNSMQYLLTAELFPLRIRALATSAAMTLHFVNQYGNSRAVPNMLLGTGEGGITPKGTFWFFSAVTVLGGLWVWFSVPETAGRSLESMDRLFALPWYQIGRHGNRDADQQDQVVADKQQQVEDGFGGAEHRERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWW6</accession>
    <name>A0A8G1QWW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_451147</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the COQ9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513823.1">
        <property type="nucleotide sequence ID" value="XM_025660522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWW6"/>
    <dbReference type="GeneID" id="37163924"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.10:FF:000004">
        <property type="entry name" value="Ubiquinone biosynthesis protein COQ9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.10">
        <property type="entry name" value="Tetracycline Repressor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02396">
        <property type="entry name" value="diverge_rpsU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="COQ9 C-terminal" evidence="10">
        <location>
            <begin position="196"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH55901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="294" mass="32433" checksum="B355A69E9BACC6C5" modified="2022-01-19" version="1">MTRSQPLLTLSRRYLTTAAPRTTTTTPIRTTTSLLTTKPTTTTTLRTIQHQPCLRTTTTTPSIRSYHSIHHPSPPHEYSNSQTTILSSALRHVPTHGFTRDALTLGARDAGFLDVSVQLLPRGEFDLILFWLASRRGLLRSKVDNDALLQSQSQQGPLSVDDKIKVLIMERLRMNVEVKDKLQDALAIMSLGENIPLSLSELHALSDDILTLAGDASVDASWYSKRMAVAAVYASSEFVMTRDTSAGLRDTEEFLTRRWADARAVKDKVSGVKQCLGFLGSTAVGLGRSWGLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX32</accession>
    <name>A0A8G1QX32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_428965</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511682.1">
        <property type="nucleotide sequence ID" value="XM_025658231.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37161633"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF404">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="885"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="932"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="968"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1026"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1118"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="296"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="611"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="896"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1219"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="852"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="852"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH53760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1429" mass="157964" checksum="E29432760E415F3C" modified="2022-01-19" version="1" fragment="single">MGIQSVCQASDASFGPVVATQCRSFDFTLLFEDVFLVCVPSSIFLILGIIRALQLYRKPIIIIRAYRVLYSSVSREMATLDIGSLANKMQTLYLTLFSIEVALLVFRQRLAVLKTSASLAAQLLRISGTCVALWLSYLEHNRTLRPPLLINIYLFLVVLFDGVIIRSFWLASNSSCITALCSTVLAAHLILLISESVKKDNSQDASRYRQTTLEETSGLFGLGLLTWVLPVLQKGFTRPLGLPDVPPVALELTSLRLKKQLQRFWEKADQSKGNQLPITLLRTYKMAFFRAVIPRLCLSAFTIMQPLLVSEITTYAALPESQETRNKGYGLIAASGIVYIGLAVSTAFYSRQTYQFIISIRGSLLAAVYAQTLTRRSGNMGTDTAITLIGTDVERISTSLRDIHEIWASPIDIGLALWLLERQLAVSCIVPVILSLGCISIITKVSKSKNRAQRAWITKVELRMHATRQALSSIKSFKVLGLCNRVEAVIAGFRSTEIATSRKFRILIFWEVLISSFPWLAAPAASFTLFTIFSFTTKIYSLNSSQAFTALSLMTLITMPVWTFIQTLPAIVQCLGSFSRIQDYIALHNASKTRLDSDSSGVLDPNRGTIVECRDAFIRWEPSGCDVLCCVDLSVPEGSFAAVMGPIGTGKTMLLETVLGETVVSSGRVSIASMPIAYCAQTPWLVDTSIRGNIVGPLDFQPDWYRHVLWLCCLTEEVQALPERDFTRIGGQGFMLSGGQKQRLALARALYSGCKMVVLDDIFSGLDAANINSICERLLDRHTGYLRCRGITVILSTNNAKVAAFADEIHLLREGTVVTYKPSPPSTPSSGHQISFPDDHEFEQLASPEQQPSQSFDANISSNGDVLDTKQGDSRPVKDRSVYLYYLKSAGLGLSVLYAVLVLVFAFCQNFPTLWLKWWSEASTESPNRPHWMYLGVFIALGLGAVVIGAASSWIYLLHMISNTAERLHLSMLSALLRAPLFWLSEANSGDILNRFNQDLELTDMTLPLAAINTTKALGACLLKMIILFVVAKYMSLTVPPLLIVCYCLQRYYLRTSRQVRLLSIETKAPLYQHLSETLSGISTIRAFRRQRWFERNNLLLVDNSQKCVYTLFMIQQWLTLAMDLLASGLVVLLMFLIVFTRDSFNSGSSGTAIVTLMSFTQSLARLLKFWSLTESCLGAVSRIKSFAETVPSEEQSKRFDADSLSLNEKVTWPSHGAIEVDKVVAAYRSHPVLKSVSMRIEPGDKVAICGRSGSGKSSLVLCLGGLLPIQSGAVRIDGVDIINVSSQDILKHLSVVPQDPCFLPGTIRLNIDPDETLSESALEGVLEATHLSAIVQKMGGLDADIKPELWSAGQGQLLALARSMARKSVVLILDEAMSRVDHSTQSLMEGIVASHFNHCTVLSIVHRYENIFAYDKVALFEDGALKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY03</accession>
    <name>A0A8G1QY03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable kinetochore protein NUF2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Probable kinetochore protein nuf2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_451844</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NUF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512879.1">
        <property type="nucleotide sequence ID" value="XM_025660684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QY03"/>
    <dbReference type="GeneID" id="37164086"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.60:FF:000003">
        <property type="entry name" value="Probable kinetochore protein nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="17">
        <location>
            <begin position="28"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="18">
        <location>
            <begin position="281"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="175"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="353"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH54957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="463" mass="54628" checksum="447CD9EE8BF416E9" modified="2022-01-19" version="1">MAYGSRMSQQFHGSQQHHNRGRKKEDDNDALMRLPDKEIAGCINDIGIPFTAADLIKPNPQQIQMVFEWFAELLMNMTRETVEPAMRAAADDICGDYPDIVPTDTRNLMGFFTSLRRLMMECGVNDFMFTDLTKPTHDRLVKIFSYLINFVRFRESQTPVIDEHFNKGEKIKSRIDTLYTENQEMEQRLEEMRRTMKANEAQVKDKVRRNDELKARLLELRRNQERVAEMLERAKADKARRQAQLEEKTERVVRTRQEVEKLRPYVMESPISLQASLSDLSENLLREKAQIDAMEKRARALQTSSDTFTVVSNDVQACVRLLEDISVELQKEDDEESRASRNREAISERGNNVREVEQTEKLLQRQLARWNERIEALRKNAQEKAEIAQARMEELREVQKQLREERAEKQRDMERRRIRIEQTEKKMADLKENIESEIQSAHDEYLKLESHIKLYITDMEKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY13</accession>
    <name>A0A8G1QY13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MYB DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_451861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512894.1">
        <property type="nucleotide sequence ID" value="XM_025660689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QY13"/>
    <dbReference type="GeneID" id="37164091"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000137">
        <property type="entry name" value="MYB DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013867">
        <property type="entry name" value="Telomere_rpt-bd_fac_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052833">
        <property type="entry name" value="Telomeric_DNA-bd_trans-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807:SF1">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08558">
        <property type="entry name" value="TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="602"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="373"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="434"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="582"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="683"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="769"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="442"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="689"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="771"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH54972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="800" mass="88396" checksum="057B7028431E9A91" modified="2022-01-19" version="1">MSHPLEEDDGSLSPPASKKRRLESEPADLSLPPPPTTLTADQVPGNQIEEELASALGSGVVDPVDHPVDRPLDTPAPIEGSAESAVPQPESSADIDSDMATVISSIMNHAERVEEQCVLGQQQLAETSSASPPKGMVFVKANSHLKIQSLPILDNLSTQILSLLAKSSYQEITSFVSEPETESGQAYATMRSLFDHTKKVYSSKKSFLSPTELELTESSQIDIIRKANLASFVSSIFGTQEIGFSELNDNFLDVFVPEGGRLLKVQGALFLELKTQAFIASMNNSERTRTELLYDLFPDELEQQLLDRRPGTRQLAPSEADFVKRAGSRRDILLSDVNNEEAMKALPDKYHWEDFLRDLSSYITKNFDTISNQQTKKTAKGRQPSSSDGDSQPSNAPLQGQFPVSTQPPDVPVDRNMHGDLVARAARAAQIALQGHGLRRSQQQQAQQNQQQQPSQQQPQQHQQQHQMHQPQQLQQQPPQHAPQQGGQILHGYSAAQPTGQMQHQQTHQQPYHHSPAPSGYQQPPGQLTFQQSPLQANFQQYNHVTPASIPRPNSAAANHGYMPGIPHYSQSQPTQVLYERARMAASAKSSPSSRKSGLPSQRRPWTTEEENALMAGLDRVKGPHWSQILAMFGPGGTISEALKDRNQVQLKDKARNLKLFFLKSGIEVPYYLKFVTGELKTRAPAQAAKREARERQKKQGEEDKAHVEGIKGMMALAGAHAQPVGMTHGHDMSASPLPPDAGAHAAFDQTAEQNLMQTLGQEVHGEAFGQHHHHHHHHQHHPHHTHHQDHVDPNMHLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYC5</accession>
    <name>A0A8G1QYC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_499037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513183.1">
        <property type="nucleotide sequence ID" value="XM_025664050.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37167452"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052957">
        <property type="entry name" value="Auxin_embryo_med"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387:SF0">
        <property type="entry name" value="PROTEIN NO VEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387">
        <property type="entry name" value="WU:FJ29H11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1255"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1262"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1312" mass="150682" checksum="C9A1136D79047018" modified="2022-01-19" version="1">MESRESARELVRSIARGRGYLSEEILERMDQDTRREVEEAMLKKDEKIGSSVLTLAKDVYNSSARFVFELLQNADDNSYSKAKSRSEAPYVSFRVYPRQIVFECNEDGFTPEDLIAICNIGKSSKTSVQGYIGEKDIGFKSVFMVAWKVLIQSGELSFYLQHRIGDSGMGMISPIWQEREEEQFQELQATFLLFMKNIEKIDVAFYDDESKETCSMLYSLEYLCKSRGKLVDEKRENGHIHVDTRHYHITKITLDKLPFLIHADFDTDAGRQDIPLSSTRNTTLLSYVGLVLATAVQEFCQHPTLQYQWMRYPPRRDELSRGSFSQELSAHIHAHLNMSDVLWTRTHSELHPIIRTRRLPSSMLDSNGDPLLRDLKPEQYLSPKYRPRDLNLLTGYGLVYMSNYGFLERVRQDLSRDDSLIRSFSVKDDDWHSRVARVLMSAYQERPKSVSALAITPLTNGEWRSSTSIKAYRIYHPHCNGYLIPEVNMRLVDSRAEKNPDRERLFSQLGVKNPKVSRVRDAIIRTNYNKTVDLDDSRAQLEFLYLTAHLDRRNDSAHFYSDIDLIDQQNRYREPDSHTFYFPGKDLYSAEQLLTPTKPAGTGKSSRPSVYILHSRYMEPRPIKPIGERRTWMTWLSESLQVRNTIPITDSTRLSPECTFIAEHHPEKLVGFLVKNWKFDAALLEKQKLVDKLLELQVVCESGSSYCLGETYVPVPELSYLRQFLRDEDDFPWLKIDNTWLSELNDMAKALGFGFPKSELEAYLRALQSIKESSDGNDATLNETERVYDLYARIQAQYSETSTPDYCRSLLRTAFASQNLIYVPNIHDEAERPCWESSGNCLWEAPQSMECKIPLKWKYNDVKHGSCLAKLFNKTLGIPNVGLNDLLKELNSLSAKGCDNVDRILILYREIDKCRPKMNKETTEKVRRNFEMRKLIYSNGKATGEWHSPSQCLWSTVTNTRGIVTLKDLYKDLQDFFVELLGVPTLTAEMVYSKLLEQGRGMTPINEVKDIIWLLNSYLQSEEDPPSSTSLLESRVFPVRYPNGVVELRSSTVDFTISDRKHLSQYFFDKVLFLDFSTEEVLQLEPFIEWAKIETRYISSCVKEISCYTGDSYRSPTSPDRKLSQKAYGLLRIAVHYKSPRLVDGGRAFYDILKNIDVRETDGITCELHLQQDGKEIKAKVSEGEIHIEEITDGLHIYVPRDPKAQYICFLDRIHKDLLEWILTEPSTAIFKPYSEKALTLMAGIVSIETPEDLSGVDVDASNPTDQTSVENSHAIRGSSSRSNSISASDTNDTIANELSDDGHGAQDLGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYD6</accession>
    <name>A0A8G1QYD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_461322</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513059.1">
        <property type="nucleotide sequence ID" value="XM_025661778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYD6"/>
    <dbReference type="GeneID" id="37165180"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF7">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH55137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="506" mass="54982" checksum="CBD4E16D359CC768" modified="2022-01-19" version="1">MDFKTVEDGNPIEPKQATASVEEHALVKPSGFFARIRYYEELLDRKMGVESHSLDRVLPEDRKPPNTLAMAFIWASATMNLSCFSTGFMGKEFGLTLGQTIAIMICATFLGAALTGWCATMGPGTGLRQVAISRYSFGFYPSSIIAALNVVEQLGWASVSCITGGQALRAVSDNHISMVVGVVIVACVSLCFSFFGLRAVMTIEQYIWMVSFVVFIIVYGEAAHHASLSDPGTVSGLTKSGNVLSLISVIYGSSASWCSIVSDFYVHYPVNTSKVKVFIYTTLGISLPTCVGMLLGACIASALDGNPEWAAAYDEGTGEILQTIIYPRKFAKFLLVLLVLCGIGMNCIAIYAGSLSAQLFAKPFQKIPRVIWTLLVFACILVIGIAGRDHLLTVLDNFLSLLGYWNTSFFVILFCEHYFFRNGNLANYDLDAWNTPSKLPVGYAGLTAFLCGAAGWIVGMDETYYVGALARKIGTDGGDIANELAFVFTSLSYIPLRKLELKYVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYD7</accession>
    <name>A0A8G1QYD7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein transport protein SEC24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein transport protein sec24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BO85DRAFT_375857</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513769.1">
        <property type="nucleotide sequence ID" value="XM_025656193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYD7"/>
    <dbReference type="GeneID" id="37159595"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="21">
        <location>
            <begin position="241"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="22">
        <location>
            <begin position="315"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="24">
        <location>
            <begin position="562"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="23">
        <location>
            <begin position="656"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="20">
        <location>
            <begin position="787"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RAH55847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="919" mass="100406" checksum="9AF0BD5C9EC8F401" modified="2022-01-19" version="1">MAAPQGGYPPQEGYGQPADYGSPVQQPAGLATGAPAQGQAGGRKKRVYAGEAFDFGSGANAALGGQLPAGGSYGAYPPQPQAAGYQQPMYGADPTQMQAAAPGYAAPASPQVAQMTQQFGAMGMTDPHLLPPQPVAQAPQAQAPRAVPLNQLYPTDLLTQPFNVAELDYPPPPIVLPPGTSVYPSPYANCPPKYVRSTLNAVPTTSSLLKKSKLPFALVIQPYAALHDSEDPVPVVPDQVISRCRRCRSYINPFVTFLDHGHRWRCNMCNLTNDVPQAFDWDTALQKPADRSLRPDLNHSVVEFVAPQEYMVRPPQPLVYLFLIDVSYASVTNGLLATTARCIKESLDRIPNADRRTRLGFIAVDSSLHYFSIPRDGSENSDPRMLVISDLDEPFLPIPGDLLVTLSECRENIEIFLDKLQEMFQNTQSNACAMGSALRAGYKLISPVGGKMTVLSSSLPNIGHGSLTMREDKKVLGTSKESSLLQTANSFYKSFAVECSKAQVSVDMFLFSSQYQDVASLSNLPRYTGGQTYFYPGWNAARGEDAIKFAREFSDYLSSEIGLEAVLRVRATTGLRMNTFYGNFFNRSSDLCAFPAFPRDQAYVVEVAIDETVTKPVVCLQTAVLHTTCNGERRIRVLTLALPTTQNLADVYASADQQAVATYFSHKAVERALSSGLEPAREALQTKAVELLSTYRKELAGGSVSGGGLQFPANLRGLPVLFLAMIKNLGLRKSAQIPTDMRSAALCLLSTLPLPLLVQYIYPKMYSLHDMPDTAGLPDEQTGEILLPPPINLSSERIVPYGLYLIDDGQTQFLWVGRDAVPQLIEDVFGLQDKSQLRVGKQNLPDVDNEFNQRVRAVIEKSRDHRSKGVGSIVVPHLYVVKEDGEPGLRLWAQTMLVEDRADQSVSLVQWMGSLREKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYK7</accession>
    <name>A0A8G1QYK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_440897</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512911.1">
        <property type="nucleotide sequence ID" value="XM_025658789.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37162191"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056485">
        <property type="entry name" value="ARM_KRIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056015">
        <property type="entry name" value="DUF7593"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24521">
        <property type="entry name" value="Ank_KRIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7593"/>
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        <property type="entry name" value="Ribosomal_L7Ae"/>
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        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
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        <property type="match status" value="5"/>
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        </location>
    </feature>
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        <location>
            <begin position="387"/>
            <end position="419"/>
        </location>
    </feature>
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        <location>
            <begin position="498"/>
            <end position="647"/>
        </location>
    </feature>
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        <location>
            <begin position="1059"/>
            <end position="1208"/>
        </location>
    </feature>
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        <location>
            <begin position="1305"/>
            <end position="1398"/>
        </location>
    </feature>
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        </location>
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        </location>
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            <begin position="652"/>
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        </location>
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            <begin position="94"/>
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        </location>
    </feature>
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            <begin position="212"/>
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        </location>
    </feature>
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        <location>
            <begin position="279"/>
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        </location>
    </feature>
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        <location>
            <begin position="420"/>
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        </location>
    </feature>
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            <begin position="443"/>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24513"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RAH54989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1420" mass="156848" checksum="4420F9C97B07E586" modified="2022-01-19" version="1">MSDVEAVSSLPASLDAGQSAFAVKVNHQSTLGHPPSKRTTPPVAQEVDAPAKEVDPAVGDGDGPPSPKADSEAETIIQSGRESLSPEKRRKFIKHEPKRRDDANDHADAAESDLPPNDLQVRKRKSADDDDDVPSERDRPVRPASPQRRAGSPPAPIVKIEKTEEPQTVPSRVESSHPITSAPRTSRKRSFSESVDGEADARRNARQHHSAAPRDRERRDLNGISLPRPTPNDRSVSPVRSHKRTASGPQLSSDLQRKRKAPTPLISGVPRQSSEDRQSVSSSTSGSPLPSAYVRKVASVDGASASPARPMGHKKQRDQNGRTRLARACAAQELEVAMARHAERPEDLNVADNAGNTPLQIAALEGCASIVKFLLEAGCEVETRNIDRDTPLIDAVENGHLDVVKLLLQAGANPRAVNAEGDEPSDLIPSDSEDYDEIRRVIEEAKANPRPSRRSEEQTGSGNRETSSRRVAINSPRESPPVSGQRSPPYAGITSKRKSVRSEATRNDLLWTKATPENLQAFAAKGDIAGVANILNVGQRADPESMIAAAKGGHDEVLSLLLGMGDADPDPDPVPGGSQKPGYNTPMLAAIGRGNLPVIKLLLAQPSFNPTRRLHKDRTYFELSRERRADNWEEEYDLLRDAYDDYIRTKKQRKAEFSSPRRVREREKEGKRTGRRESPSPGGRPRKAMASPGRRDSSKDALSKERRREAMAHGKEKSSAPRPKVAHVGAGDQDASRSEPARFKGSSAREGESSRGDEAPKRRRLIAGRPPDRDRRVPSLPPSESISGRDENTKTRPDPSESATSKSGAPHLKRGRSSASPDRPRSRDTDAERHPRDTQKKKRRVLSEDGTPNITNGGVKKSHPTSEDLKTPARYKDDTHAIEPKRERSREPDVPSRTAEKNPVKEEQEKVETQGLEDIPMEDSTSTAEAEAKAKAEAQAKAEVKAKAEAKAKAEAEAQAQAEAEARRQKEAEKAAAERQAEEERLAAEAEKARVEEEERVAREARIAQEKAAEEERKRIEAEQRRIKQAEDERQRRLEQERQRLAKLRREQEEQEQRRRDALPSRLRAAANLVGSNDPLAKSHAWLKKFMPVVTAETKQLDPSCGPTVAEEKWVPNYLVAPLLATNDLQLSQYATWEKRNATPTQRMNLWRVTRRMLVQAEETEFLSSSFEQIMQKDCEARPKYFDMEHVFWVKLSDFMDLVPHIPHLHGLDIQFLKMHIDQEPKPQPVLELPQANGHISGTPIEEAPGLLGGNGLTNGYGHSRPSEILDSDGEETQSNPVVAADEVEVSADAGAGGQMSVLDALKGVLRISLIHDGLARGLREAAKALDRRQAHMCVLNEGCEEEAYKKLVVALCSEHKIPLIKVPDGKMLGEWVGLCQLDREGNARKVVNCSCVVVKDWGEESQERSVLLNYFQTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYY6</accession>
    <name>A0A8G1QYY6_9EURO</name>
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        <submittedName>
            <fullName evidence="1">DUF1748-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BO85DRAFT_424963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Mitofissin"/>
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        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF1">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mitofissin"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH55437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="73" mass="8232" checksum="4E81B08B52EFAFE4" modified="2022-01-19" version="1">MLGRLSHYAFDAVLISAFLAGVKRSTGLTLNSDKITDNKDFKKWIDNYLGVGEWVMDQSVAVLGSTSYFERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZI3</accession>
    <name>A0A8G1QZI3_9EURO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BO85DRAFT_450634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="RAH56604.1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="139" mass="16386" checksum="C076CA554CA452BD" modified="2022-01-19" version="1">MTSLNRDFTGSNFPGSDLHQDDLRTESLQTLQQYMSPPSGNLMDYDWDQLQEEYIASMEKHENAERDLRNRVAKLLEIFMAWSETTVMRDEIRALKRFKTQMKHVQTSEEDLELKRKHYVDVVKAFESALALLNDRLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZQ8</accession>
    <name>A0A8G1QZQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TAM domain methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_451192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513888.1">
        <property type="nucleotide sequence ID" value="XM_025660534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZQ8"/>
    <dbReference type="GeneID" id="37163936"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH55966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="323" mass="36611" checksum="0514C3FD455B508E" modified="2022-01-19" version="1">MGSIAPDLPIEVDHDDDAISLGTESSTTSLSSSVLKYEYKHGRRYHAHHLGNYPFPNDQPEQDRLDMVHHIFYRLINNRLFLAPLNPDGKRILDIGTGTGIWAIQMGDEYPNVEQIVGNDLSPIQPSWVPPNVKFVVDDVEKDWMESAPYDYIHCRYMAGSIRDWPRLIQQCYENLKPGGWLELQESVNTLYSEDESLKADSYMVKMMDGLKEACLKIGQTMDPAPEFEKWVGEAGFGAVHTMKFKLPIGSWPKDARLKECGSFMRVNFVEGVEGFTAALFGDVLGWEQSDIEELNAGVKRESLRKDIHPIFDVLVVTAQKPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZT7</accession>
    <name>A0A8G1QZT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_300752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515368.1">
        <property type="nucleotide sequence ID" value="XM_025655344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZT7"/>
    <dbReference type="GeneID" id="37158746"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017149">
        <property type="entry name" value="GSH_degradosome_Dug2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF8">
        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037237">
        <property type="entry name" value="Peptidase_WD_repeats_DUG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="805"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="816"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="856"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="894"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH57446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="973" mass="106064" checksum="D785EA4465889750" modified="2022-01-19" version="1">MEHAVLVESDSSSDTDDQTKVWESDPRSVTAHLAHDSAHAALPAECGIGHRVQASRSVLALVLDNECVFAGLQGGDIVAWSLETYDLVLSVHAHQESVLDLFLSEDGELLFSSGGDSIVNVWSTRTFDRLYSIHSHHDVGDIFAVAYSSTLKTIYCGGQNTSIQWCDISQTDAASTQRSAAQLSRRTHRFFDSKGPDGSRAPRSDPGADGVHPGGQVLTFKRDHHRLFSHHGYIYTMLLVRGLVEQAPTEEVLLTGAGDGVVKLWRLDQAKDNAVPSQIAKLQNGDPVLSIAVEGSFLYCGLAGGALNIWNLDSHQLVKRISMHTGDLWAVDIIHGVAVCGDSNGVIKKFNSRFEEIGSWVAHGGTMLASSAGRFKDRYIYASGGNDNTVGIWDLTDVSRAQPEQPRINNDEMVNCLAKFVAYKTVSSSPKFAGECNQGAAFLRRHCIYLGAKTNLLTTGADTNPIVHARFNATVPNKVDKTILFYGHYDVVGADANRDKWKTDPYQLTSIDGFLYGRGVTDNKGPILAALYAAADLARRKELRCNVVFLIEGEEESGSQNFHETVRTHKSQIGPVDWILLANSYWLDDHNPCLTYGLRGVVHANLIVTSDHPDLHSGIDGSALLDEPLKDLTMLLGTLVGRKGRINLPGFQEPVLPLTDAEKQRYAAISDVLLPHHPEIADSDALIKSLMHRWREPSLTIHAVEVPGSSKSATTTISRKAKASLSIRLVPNQEADEVATNLTLFVQEQFDRLESQNDLTVEITGKSDPWLGDPDNEIFETLAEAITAAWSPTNKPQRYAYPPIQREASQSTTSKPSKERPSLQRKDSGDSLASHIDRIIMSTTTSSAEKTARQRSSLSTTVPTSSTLASKSGASVTEEPAGTSAPDATGEKTSSSAAGGRSGSSVRPIYIREGGSIPTIRFLEKEFSAPAANLPCGQASDNAHLYNERLRVENLYKSREIFGYVFSKLPERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0E3</accession>
    <name>A0A8G1R0E3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_419896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515698.1">
        <property type="nucleotide sequence ID" value="XM_025657880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0E3"/>
    <dbReference type="GeneID" id="37161282"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588">
        <property type="entry name" value="TPR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588:SF1">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="565" mass="63414" checksum="0CFF91858A1B8B29" modified="2022-01-19" version="1">MTDDYFNLGPYGRTVTTNSSGAQLWFNRGLVWSYSFNHEEASRCFIKASKADESCAMAYWGLAYARGPNYNKAWIRFDPVDLATTITEMKPVLQRARALAAQGASPAERALIEALGARFPKEDDETKPEDLDLHALDRAYADAMRPVYEAYPEDPDIVALFVESLMCISPRALWNLDTGEPCGPHTTEARRVLEKAMASLPGASNNPAYCHLYIHLMEMAPYPEVALPAADRLLRLVPDGSHMLHMPSHIYVACGDYRAVIDSNNQAMAVDDKYFAREPGTLLYIMYRSHNIYVKVYGAVISGNFAEAISGMKRLQEILTPELLSITTPPIANWAEGFLGAIAHVLIRFGRWNDILDLQLPKDKELYASTTAMIYYARGIALAVLNRVEEAKEEREKFEAARKKVPPSRLNSLPVREVDVLEIGSAMLKGEIEYRQGNFEEAFDHLRQATKLEDNLVYADPPPWMQPARHALGALLLEQGHVSEAQHVYEEDLGLSETLPRRKARLNNVWSLHGLYECLIRQGMHDKARYIRAQRDVALASADVPINASCFCRLSAVELTNVCCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0F9</accession>
    <name>A0A8G1R0F9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RING finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_401501</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513422.1">
        <property type="nucleotide sequence ID" value="XM_025657162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0F9"/>
    <dbReference type="GeneID" id="37160564"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000512">
        <property type="entry name" value="RING finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="191"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="569"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="694"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="569"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH55500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="731" mass="80990" checksum="0425A598F131C1FB" modified="2022-01-19" version="1">MSGNPSQIPTTSMKAVNIPSQPASATFTPSSFDSGSPRSQRRPGGSGSFGAGLTSQARNSGSPRHNQALRSQHKRQRRPRLLDDEDYSESAIMRSTTSRKGQTSITHLMNFSLPPRPQYHPPPRNTRRYTSWGPGSGYHAMDKSRYVHANYRFIVTPNRNYHAQAANADVHLDWDSVMQVLVSEQTQSASCPICLSTPVAPRMARCGHIFCLPCLIRYMHSSDEEKPVPEKKPRWKKCPICWDSVYISETRPVRWFRGQEGDLPFEGGDVVLRLVKREPGSTLALPRDGAEGIAPDEDVPWYHAAEVADYARIMKGGEDYMKEQYDIEIDELRRQELEDELLFGDDTTWTRKAVAAIADAKSKVEGIGNPPEIVRQPVPNQETKEPVAAHSPPEEVAAMYASQHAIKSGQSSSAESIPASDTGPGSASTPETSNDVDRTSEALGQVDLNATSTPKKKKKDPGHGRNNMPSKRGPTTSDHAFFFYQALPQFYLSPLDIRILKAAFGDYSSFPATILPRVERISSGHIVDDELRKRVKYLSHLPQGCEVNFLECDWRDVVVPEVLETFKSETEKRRKRNKEKEVREEKDRIRAEKEEDEKRWAAARRKRPSIGPIDEPPFSDRDFQPLSGSAGEPSGFDIGSSSASPPPSSSPPGSRTVWGTVAAPTLSAPSSSQAPADGWLQGWEEELWAQQERELMAQSAAEANTVASSSGGKKKKNKKITLMSTNIQRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R182</accession>
    <name>A0A8G1R182_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_498327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513842.1">
        <property type="nucleotide sequence ID" value="XM_025664028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R182"/>
    <dbReference type="GeneID" id="37167430"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040:SF1">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH55920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25306" checksum="3662AF1186259574" modified="2022-01-19" version="1">MHQEQLRHLAEAVLFTTLTMSSNPATPTIKLVDSLSTLHELLENLRLIPRSSPPLFVDLEGTNLGRSGSISILSLYAVHKGIIYLVDVYKLGRSAFSNHQPGKNTSLRGIMESPSIKKVMFDVRNNSDALLSHYNIHLDGIQDLQLMELATRSGSKKYSYLQSQKGRMEKTQGGDYQADYCAADVSQLPGLYNTYERRMSPTWRTKVQNATNDRIQLSQKPEYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R289</accession>
    <name>A0A8G1R289_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_372414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515238.1">
        <property type="nucleotide sequence ID" value="XM_025656038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R289"/>
    <dbReference type="GeneID" id="37159440"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH57316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="43970" checksum="34C9C8DB2514B46C" modified="2022-01-19" version="1">MGMHNVDAGSSDVGQDRLEQEMKRRLWWHLTCTDWLLGSAPGPQQGIYMISPHHTTVKYPANIEDEDLTEEGIHRHPKPDRHPTSMSFFLCRLKFAQLCRESMDAIQHAKTTQPSQLIYPLILEISDKYMSFLRELPWFFRLEDEEDEAKRTDLTKKQPYISHQRAVLLYGIYSRLGRLHRPFVTKGIADPGFAGSYNIGIECAERLLRIRRMAAVHGSQLLDIFGRSQSVDQHTFNAMLLLTIDVMAHPNSPDSERRRADVIEICHILQDKHVRLGQPANGISRAVQMLLDIVRNSNRPHIKDKDRIDSTGQVGSNTAQSMDSLVVPDQCTMASEASYQTAWIDEFLSISDDQDMDTLFDELWGSYSETSIPSREGFLNREGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3C0</accession>
    <name>A0A8G1R3C0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_449484</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515416.1">
        <property type="nucleotide sequence ID" value="XM_025660176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3C0"/>
    <dbReference type="GeneID" id="37163578"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000009">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="123"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="222"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH57494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="324" mass="34892" checksum="2F51419DC215A705" modified="2022-01-19" version="1">MASPTAAKEPQPAMDFLHHPYTRAALPFVNGGLAGMTATVVIQPIDMIKVRLQLAGEGVRTGPRPSAFGVARDIIASGKALDLYTGLSAGLLRQAVYTTARLGFFDTFSKTLNKRAEAANRSVTFAERAGAGLAAGGIAAMIGNPADLALVRMQSDGLKPPEARANYRSVMDALFRISKHEGVPALWAGAFPTVIRAMALNVGQLTFFAESKAQLKKHTSLSTQNQTFAASAIAGFFASFLSLPFDFVKTRLQKQQKDPKTGQLPYKGVLDCARKVVQEEGWLRFYRGFGTYYVRIAPHALVSPPFAVTSHLVVPLANPRPTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3N1</accession>
    <name>A0A8G1R3N1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_395856</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516590.1">
        <property type="nucleotide sequence ID" value="XM_025656975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3N1"/>
    <dbReference type="GeneID" id="37160377"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050501">
        <property type="entry name" value="ICDH/IPMDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011829">
        <property type="entry name" value="TTC_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02089">
        <property type="entry name" value="TTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275:SF2">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="7">
        <location>
            <begin position="9"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="624"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="713"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="734"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1096" mass="120224" checksum="7888A6B2A4F68083" modified="2022-01-19" version="1">MATEKPTYRIASIPGDGIGEEVVRATIEVVNKLAQTLNTFNIEFTHLPWGTDYYKQHGRYVSEGYLDTLRKFDAGLFGSVGHPDVPDHVSLWGLLLALRSPLQLYANVRPVRTFPGTKSPLTTAVNGIDWVLVRENSEGEYCGQGGRSHTGQPWEAATEVAIFTRVGVERIMRFAFETARSRPRRHLTVVTKSNAMRHGMVLWDEVAEAVAKDFPDVTWDKMLVDAMTLRMISKPDSLDTIVGTNLHMDILSDLAAGLAGSIGVAPSSNLDPTRKNPSLFEPVHGSAFDIMGKGVANPVATFWSAAEMLAWLGEKDASKKLMDCVEKVCAAGVLTPDLGGSANTQGVVDAVCKEIELQLASSHPDLRLPIQSEILDFNAIFSSMLSPYPRQKHHDPTRMEPPDLTNGPSEIGSLTAHSKDESQFVGSSSGVYFINTVRRAFSESLDPTGSSPAQDFPQPEDTLVGSDVSQKTTPAALQDDQFPSQWAYDPAVAAVLGNAPPLDTARELMMIYFKVWHPLFPFLHGPTFLQAMEGLYSEDRQEPTGNAPMADHRHVCWTTIFQCIFNLANAVHPEIQLPLGSRIESPSNMHSLLGTLTSKHDMLSLQALLACQLYLLAKMSLRTASTVGGCMLRSMLHAGLHRCPYRYKELTTHDRQLRKRIFWCAYAIDRYLSQALGLPLGVQDSDIDVCSPNAPEIHIPGMYNRSHFARSTSYPEQRGHCPQLTSNQHHENTSPRTFSAHSSPSAEEAQQNRRELAFASYVESGTLTGRALELFHKSITVRSVPRSSVLFLITDVHKWWNNLSIETLQCQHQQSSTDQPSSSSPAATTTTAFNFAPFFTVLYQHLILLINRPSLSLSPSTPEFCSGLQTCINAAREIISALTTQQESGQSFFWPGFLSAAWMSGLVLAFACQLRQYVLSKGAQEITKCLTILHTMSTQWEAAKHCHRALSLLSRTIQESGTTTAAAGEGSPNKRRKVAVDPHHTAFFTPINSLSSTNMDDEYARGRAGRRTPTAAAAAAAAATTSGLHETANTSGGHVHLSHEDRLFAAEGVSTNTNDNNNGDAVGEFDFGIVDLLEGSNFDDLADMFGQQYPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4N4</accession>
    <name>A0A8G1R4N4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_520862</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514677.1">
        <property type="nucleotide sequence ID" value="XM_025665172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4N4"/>
    <dbReference type="GeneID" id="37168574"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="3">
        <location>
            <begin position="131"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="341"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH56755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="547" mass="63051" checksum="AA506A9B228DD161" modified="2022-01-19" version="1">MDWKYKPPTEGQTHNRDPSSGERLQWSHWYQPGSSNDDQIYDNALQRCKEVNEQLSSQPWWNDQCDLVASSKTVESMPVRLKPPGRYDASWVQDLIAKERFRINKKNTSESAWRHKVSGFADDVIRVATLIKPIVDIFVPQSPECSVPYACLWMVFKGVSSRKEKKESVFGLITSLSDEIPTLQAYGDMFPTDEMKETLSQFYIHTVDLLWRLAKYYAIGFFKQLTDAILPRTKYDFPTYLDNIKKSTTRLKALCELGHMAEQKDIKGNLDVLHSEIRHLRLQIEMSRGIQGRRYASDLIDIWHDDVGDIEHEHQLWQSLRFSTDMRDHWSQNGILPCLAEWREHCDTSENSILWVSSQSNGRQSWLTEFTLDVVSVCRSQGQDIMIAMCDRPNGVKWTPAQLLRQLIAQLLIDHPELTVFRPGIFNARTFRRATKFDALYRLLNSVVAVLKSVLIIIDRLDLCVADPNEKDDDITRALSILARAYPNLRIIVTTGEIVSPSMLPGLPVSFAMVNTRRHPRRRPSPSPEPPPTRRPAGRRQYERVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R502</accession>
    <name>A0A8G1R502_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_496899</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514827.1">
        <property type="nucleotide sequence ID" value="XM_025663970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R502"/>
    <dbReference type="GeneID" id="37167372"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13279">
        <property type="entry name" value="PH_Cla4_Ste20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15413">
        <property type="entry name" value="PH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="78"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="551"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="264"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="336"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH56905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="841" mass="92950" checksum="1B47532D5A0EDC21" modified="2022-01-19" version="1">MYSPDQFMNPGPAPRPPADRPQLNLPTNPSNNVATSFSQMSLNSPSTPGPANLSLFPNTSTPSLTRTKTDQSGGGGVTVIKEGYVRCKEDKFLATWNQRYLILREFRLDFLKNETGKIVLSIPLTAVTGVSRSEDTRMAFEIIRLANPKDANSKTAVITRDVPTKSITCEVKSDDEIYDWIDKIYERCPGMGGVSNPTNFSHRVHVGFDPRTGAFVGLPPEWEKLLTASAITKEDYKKNPQAVIEVLEFYSDIKMREQNPQYYAGLSSPANQQAKPFSGGGSVGNSIAPPRPPPPAPAQRLDSGGQSYSSQSPVSSPSQSKSDSDRALEQQQQLERMNELADKERRRMEEDRRARQREEEQNRLDQEAYNASLPKTRVPLAKQELGGYGQSSDDRYKPSRPAPQAPGSSRQEPPRQLTAQRPAPSAPTAGQRPGDYANGSARAEQSSPGSRHPAQGQSPARAQNNGVKAQPAQGPPPSKLPAPVQPVKPLNIANKQTAKTNVPDGVRQAEAALSKKAEPRQREVRMSNMSENEVMDRLRSVVSKDNPNESYSKQRKIGQGASGSVYVARVKEHATSGVARELYRQYGPRTQVAIKQMDLRSQPRKELIVNEIIVMKDSQHANIVNFLDSFLQEQSNELWVVMEFMEGGALTDVIDNNPVIQEDQIATICAETCKGLAHLHSQNIIHRDIKSDNVLLDRAGHVKITDFGFCAKLTESKSKRATMVGTPYWMAPEVVKQKEYGPKVDCWSLGIMAIEMIESEPPYLNEEPLKALYLIATNGTPRLKKPEKLSKELKSFLSVCLCVDVRSRATADELLAHDFLKLGCSLASLAELLRWKKNSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5L2</accession>
    <name>A0A8G1R5L2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_477771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516077.1">
        <property type="nucleotide sequence ID" value="XM_025662851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5L2"/>
    <dbReference type="GeneID" id="37166253"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="22407" checksum="456BB325812410C8" modified="2022-01-19" version="1">MPRQRRGAAPTPARSAPTRPTAAPARPAAAPSYGQQQPHSTAAHPQQQHHAPPPAAAPAATPAAAPVQQSQGPGLFGQMASTAAGVAVGSSIGHAIGGMFFGGGGGSSAPAEAPQQAAPAPAQPMDNGLWAGNATNSSWEAPACATDAQNFRKCMDENKGDLTICGWYLDQLVRFPGVGVGDCEWLLGEYANGYCVYRRLARLLLSRTKWRLSIEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5L7</accession>
    <name>A0A8G1R5L7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">aromatic-amino-acid transaminase</fullName>
            <ecNumber evidence="9">2.6.1.57</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_367366</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an aromatic L-alpha-amino acid + 2-oxoglutarate = an aromatic oxo-acid + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:17533"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:73309"/>
            <dbReference type="ChEBI" id="CHEBI:84824"/>
            <dbReference type="EC" id="2.6.1.57"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.57" evidence="9"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517920.1">
        <property type="nucleotide sequence ID" value="XM_025655814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5L7"/>
    <dbReference type="GeneID" id="37159216"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000074">
        <property type="entry name" value="Aromatic amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="177"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH59998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="532" mass="58681" checksum="C43BBFA4A44D201F" modified="2022-01-19" version="1">MSPPVAVDNDSNNVGSVAATGPLTVDAIPALRAKSAKVPTGVAPATNSDMFKSPHCFTKPQSKRWDHIFSVESKSRKSSTLKGAARYLKNPGLISLGGGLPSPEYFPIEQLSVKVPNAPDFSPEAIQNSGALLTANKGDVRTGKSLFDLEVALNYGQASGTPQLLRFVTEHTELIHNPPYADWQCCLTAGSTYAWDTILRMLCNRGDYILMEEYTFASAQETALPLGLKVAPIRMDGEGLLPESLDEVLSNWDEAARGGPKPYVLYTIPTGQNPTGATQSAERRKAVYKVAQKHDVYIVEDEPYYFLQMQPYAGADSEPVPPPATHEDFLKSLVPSYLSLDVDGRVLRIESFSKVLSPGSRAGWIVAADQVVERFIRNCETSAQNPSGISQLIFYKLLDEHWGHPGYIDWLINLRMQYTGRRDTMMHACEQYLPREIAQWIPPAAGMFHWIEVDWKKHPGLASGKTRESIEEEVFLAAIDNGVLVSRGSWFKASGVNEEKMFFRATFAAASSEGITEAIRRFGDSLRVQFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5R3</accession>
    <name>A0A8G1R5R3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_447167</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518518.1">
        <property type="nucleotide sequence ID" value="XM_025659662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5R3"/>
    <dbReference type="GeneID" id="37163064"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="234"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH60596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="291" mass="32957" checksum="189F7EE2EE4A24EC" modified="2022-01-19" version="1">MSERKVLTKYYPPDFDPSAITRTPKHLRQQGPKVITVRLMAPFSMKCTKCGEFIYKGRKFNARKETTSEKYFSIPIYRFYIRCTRCSGEITFLTDPKNVDYRAERGAKRNFEPWRDRSKAEETAEETEEQVLDRLEREEGENVEQEERDKMAELEEKMLDSKREMAIADALDEIRTRNARIERGGAGGSEVALGAVREERDEEAERVEREIEEVARRAFRTEEGEMVRRLVVEDEGGLDNGVGASGSGTANASGAGEMPPPPAPSFARVKKAKKPAVNSLGIKKKAKPSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5S6</accession>
    <name>A0A8G1R5S6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DASH complex subunit Hsk3 like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_486791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517098.1">
        <property type="nucleotide sequence ID" value="XM_025663405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5S6"/>
    <dbReference type="GeneID" id="37166807"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042332">
        <property type="entry name" value="Hsk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013183">
        <property type="entry name" value="Hsk3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08227">
        <property type="entry name" value="DASH_Hsk3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="11904" checksum="CE2F8041FAC97974" modified="2022-01-19" version="1">MPSHQYTHSQSLPRHSILPASTTAGPSSSMGSSSMSMAKTRQYTNLHNQLEQLNANLRDTENLLRMTAVQAEDMRFLGGYVGALFMGSAKVLGEEGVKGDSSGDEEKREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R675</accession>
    <name>A0A8G1R675_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conidiation-specific protein (Con-10)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_485405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518171.1">
        <property type="nucleotide sequence ID" value="XM_025663325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R675"/>
    <dbReference type="GeneID" id="37166727"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019626">
        <property type="entry name" value="Stress-induced_KGG_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10685">
        <property type="entry name" value="KGG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="87" mass="9147" checksum="29B9264FA144770F" modified="2022-01-19" version="1">MASNSNPGNFANRSHDEVSNIAKKGGQSSHSGGFASMDPDKQRDIASQGGQASSGSFQPGDPRARAAGQKGGSRTQYDQYDEDEPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6B7</accession>
    <name>A0A8G1R6B7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Superoxide dismutase</fullName>
            <ecNumber evidence="13">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_446674</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="13"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518015.1">
        <property type="nucleotide sequence ID" value="XM_025659554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6B7"/>
    <dbReference type="GeneID" id="37162956"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000004">
        <property type="entry name" value="Superoxide dismutase [Fe]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF29">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="14">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="15">
        <location>
            <begin position="100"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH60093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="210" mass="23780" checksum="F49251906E36B78B" modified="2022-01-19" version="1">MTSKYTLPDLPYDYDALEPIISKQIMELHHKKHHQTYVNNLNAALASQASALDSNDITQLISIQQKLKFNGGGHINHSLFWKNLARYDSPATKLEQSAPTLKDAIEKQWGSVKNFTDAFEAVLLGIQGSGWGWLVSSGKKGFLEIVTTKDQDPVTGPIPIFGVDMWEHAYYLQYLNNKASYVQNIWKVINWEEAEHRYLNGTDELGSLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6C9</accession>
    <name>A0A8G1R6C9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_418633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517244.1">
        <property type="nucleotide sequence ID" value="XM_025657829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6C9"/>
    <dbReference type="GeneID" id="37161231"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="31"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="353" mass="39335" checksum="41BF55898CA94648" modified="2022-01-19" version="1">MGRFTGDTKDPAVNVSTWFLLVTASLSVIFRLGTKYGSFRTFTNDDYLIVVSLIFCIGQSIAVSMAVANGYGYHYSTLTPERFDNMMKSQYAAALLYIPSLYFSKISLSCFIRNLTPTAKDHRVANLVQISVTVMAVICLLGTSFQCSVPQTWNYYTGKCMNLIAWHYFTGIMNIVTDTMITSQALYLIARIQTSWKRKFVFASIFLSRVLVILVSIVELILVSQNDATHDPSFSTWGVTISVETIQCLSIVTACWAQLKPFLNMLKSNGLRIQGVDYRSTNNRSKWSTTRSANPTESKFTRSGEHELMGMGAGQGNITTVSAARLSDEDSQSSQAGIIREVRTWVVSEEVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6F9</accession>
    <name>A0A8G1R6F9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arrestin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_372192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515577.1">
        <property type="nucleotide sequence ID" value="XM_025656029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6F9"/>
    <dbReference type="GeneID" id="37159431"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053060">
        <property type="entry name" value="Cytokinesis_Signaling_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419">
        <property type="entry name" value="ARRESTIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419:SF1">
        <property type="entry name" value="RHO1 GEF LOCALIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="1">
        <location>
            <begin position="185"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="401" mass="44432" checksum="3A06B49B7DB4FEB2" modified="2022-01-19" version="1">MAAFVRVSGPPNGHFLIGYPGISATMPRIEGKVEIRPSVGITAPVNVSLVTISLHRRETIHPSADSVTKKHLAPPRKEITDIVGKEMLLFRCPAGREYEEVISMDLPFVLFIPFGRGGPDASRRVPPASLQLPSRTAETFYEIVVMVQQGHSDQRKYTFPVPISRYDTLSTFGMYNRPESAERVSDHLVTLGISLPRWSYGPLDPVSVYVKLSPNLDWIGKARKVTINKITIGIDEEIIYNHEGDEPQRKVRTLTKRTEPIGVKLPPSGFLTNLGLVFPAKDLRDSKGILPRSDMAFPAYAVTGFTTTASLYKIEYYLTVKAHLTSARDIVIRQPIVVCPLDHAGCKEEMDAIEQAAREAVHINPDNPMLPLPSIVRPNDPNALRHLGVAIVGNQKKPLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6G0</accession>
    <name>A0A8G1R6G0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Guanine nucleotide-binding protein alpha-2 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_366801</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518355.1">
        <property type="nucleotide sequence ID" value="XM_025655794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6G0"/>
    <dbReference type="GeneID" id="37159196"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000009">
        <property type="entry name" value="Guanine nucleotide-binding protein G(O) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF242">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="47"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="181"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="206"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="275"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH60433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="359" mass="41282" checksum="A5DB336C049284E5" modified="2022-01-19" version="1">MGCMSSKPVDTADKDAVQRSARIEKVLKNDKKVMDRTIKILLLGAGESGKSTIIKQMRIIHSGGFPEDERRQTRAVIYSNLVIAFKVLLDIMRAENIDFQLEKTKPLAEYVDKLEPDVGSDEAFSDLKVRDALREMWDDTGVQKAVARGHEFALHDNLHYFFDSLDRIFTPGWLPDNQDMLQARLRTTGITETLFELGQMNFRMMDVGGQRSERKKWIHCFEGVQCLLFMVALSGYDQCLVEDQNANQMHEAMMLFESLVNGEWFKRKPIILFLNKIDLFKGKLHVSPVSNHFPDYNGSNTDFDAAARYFADRFRGINRIPDREIYIHYTNATDTTLLKATMDSVQDMIIQKNLHTLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6Y7</accession>
    <name>A0A8G1R6Y7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_486990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517321.1">
        <property type="nucleotide sequence ID" value="XM_025663424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6Y7"/>
    <dbReference type="GeneID" id="37166826"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052078">
        <property type="entry name" value="Trehalose_Metab_GTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779:SF1">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="155" mass="17601" checksum="7A95F93AE82A8600" modified="2022-01-19" version="1">MSTMSVPPTTRDTGTERRTSLYELRQVKTEVAENDWTGPPLNVIYAGVAARFHLLTGATIAVAVRDSTYLLDYAQFTFSTSSQGRYQAEIAQFIVEKMREYQEAHGEKFIGLAMPTDLAERCPDLCARLWSELDIIPIVLRKSEEKLSWGMFEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R775</accession>
    <name>A0A8G1R775_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_228210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518389.1">
        <property type="nucleotide sequence ID" value="XM_025654759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R775"/>
    <dbReference type="GeneID" id="37158161"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="11">
        <location>
            <begin position="40"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH60467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="399" mass="43560" checksum="C4FAB29414EA0190" modified="2022-01-19" version="1">MSEGEKARTSGEVSRPEPTLPTVNPAVDKAEPPKPAFHPAVYVGVWITLSSSVILFNKHILDYAQFRFPIILTTWHLAFATFMTQLLARTTTLLDGRKTVKMTGRVYLRAIVPIGLFFSLSLICGNVTYLYLSVAFIQMLKATTPVAVLFATWGMGMAPVNLKVLMNVSVIVLGVIIASFGEIRFVFIGFLFQLGGIVFEATRLVMVQRLLSSAEYKMDPLVSLYYFAPVCAVMNGVTALFLEVPNLTMGHIYNVGVWTLLANAVVAFLLNVSVVFLIGKTSSLVMTLCGVLKDILLVAASMMIWQTPVTLTQFFGYSIALVGLVYYKLGGDKIKEYTGQANRAWAEYGVNHPAQRKFIVFGAILLIFFLLMGSMAPSYAPEQVASVKGMLGGATAGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7P2</accession>
    <name>A0A8G1R7P2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Required for respiratory growth protein 8, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_518222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518644.1">
        <property type="nucleotide sequence ID" value="XM_025664956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7P2"/>
    <dbReference type="GeneID" id="37168358"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034179571" description="Required for respiratory growth protein 8, mitochondrial" evidence="2">
        <location>
            <begin position="29"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="53502" checksum="B2432C037018841D" modified="2022-01-19" version="1">MSLSAAAAFFPRFLKTIFLLLTTHHAMACLNSRISYASWRLRVFRQLFRPNGFPEVGYRAISTSNGTREPRPTASSADKTLKSTPTENKEAVAASEESEKGSKQHLRPSELLPQSPLLTNPRPGHDKLHKKKRRPDPKESDIHLNPWAQALASPLRACKVTGARVPRAFMSEWGFVQRPDVEDKLWLLPVGLMKDKLNPSSTTPSQEEGHTKDDNDNHNNKNNVKKNTTRHLTLRIVDRLPLLRTLTSTYWSTKTNRKREPLAKLLPHRWKHPLGPVTSWEESQLSLREDTPTFTLKMMRRDVVQKLKAACDPPDTQPEAKRRVWTVLPVSKYGRAHIARRTWSMEPFERMECCGVLVNNRRRGKPGRVTGLWPRMPEIVCISKQKKVAPVFDLTVMLGEEELAELREYCPGLFGKTAVVLRPDNKVTVDAMLALWRLRGFVRSDGVLEPPRMEVRLRSKWRSNYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7W0</accession>
    <name>A0A8G1R7W0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Beta-1,6 glucan synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_252144</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517786.1">
        <property type="nucleotide sequence ID" value="XM_025654942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7W0"/>
    <dbReference type="GeneID" id="37158344"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="13">
        <location>
            <begin position="236"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH59864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="666" mass="74222" checksum="E46552BFE34DBB85" modified="2022-01-19" version="1">MSEEAILRETPHIRVNSGQHDPFADSDDPYVSVPPQQMGRSLTPGMVQSASEATFPTTWGSPTPQESTELLIPPRPYRVREELRSPELSIRSSRRTSWSSEAVSYDARAYLYSRFEDSRAPSRAESEGDDVNTQTVTEKYNIMPTEGLLLFPEDVEKDDYMHNPDPNDRDIVCDVWNKRGLVNLGGLLLMTVGFVVLFVAYPVITALGGISRKYVPTCDPADTLCLDVGDRAGLTNLRTGLIDPDTPESAMTKKTVDGKEWQLQFSDEFETPGRTFYDGDDAYYQAMDFWYGVTQDLEWYDPDAVTTKDGSLEIRFDAFTNHELGYRSGMVQSWNKLCFSGGRLEASISLPGAGDVSGFWPGFWAMGNLGRPGYAATTDGTWPYSYYDGCDAGITPNQSSPDGINFLPGMRLPACTCDGADHPTPGKSRGAPEIDVIEASVGPLNNNPNAFIGTASQSLQMAPFDIWYMPDYDYTAVYDPRITEINSYRGGPYQQAMSGLTNLNNRWYNGTEYQVYAFEYTPGAVGNVTWFVGQDKTWTLDGRAIGPNGNVGQRMIPMEPMSIVMNLGMAWSFAPINETIRDIMPGFMRFDYIRIYQDPDNISITCDPPGYETTEYIASHAEAYTNNNITTWYVYPFPGLCSVEFLMHSRGDAGYDWPTNSLMNGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R884</accession>
    <name>A0A8G1R884_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_244897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517472.1">
        <property type="nucleotide sequence ID" value="XM_025654872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R884"/>
    <dbReference type="GeneID" id="37158274"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="80" mass="8931" checksum="44250E7A48EA51FF" modified="2022-01-19" version="1">MVMLPAPARCSISSPTLAISIVSRIPSTSALFLDPRSMPELNAAYHRIFFVFIGKEEKRSIIRGERRNNLVQEIEIACIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9D3</accession>
    <name>A0A8G1R9D3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="3">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_448094</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="3"/>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517077.1">
        <property type="nucleotide sequence ID" value="XM_025659866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9D3"/>
    <dbReference type="GeneID" id="37163268"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000010">
        <property type="entry name" value="Acyl-protein thioesterase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="13">
        <location>
            <begin position="6"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH59155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="243" mass="27061" checksum="BE887DF6DA7374CB" modified="2022-01-19" version="1">MTTRAPFIVPALKKHTATVIMAHGLGDSGAGWMALAQNWRRRGMFDEVAFIFPNAPMIPITVNFGMSMPGWYDISKLGRDLDFEEAIRHQDEPGVLRSREYFNSLIKEQIDKGIKPSRIVLGGFSQGGAMSLFAGLTSKEKLGGVFGLSCYLLLHDRIKDFIPENWPNKQTPFFIAHGEEDEVVKFDFGKQSAKKVQELGVEDVEFHSYSDLGHSADPDEIEDLTRFLQKAIPPEEGQSAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9E6</accession>
    <name>A0A8G1R9E6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3 10">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_388380</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3 10"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519484.1">
        <property type="nucleotide sequence ID" value="XM_025656710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9E6"/>
    <dbReference type="GeneID" id="37160112"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="35"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="85"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="151"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH61562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="261" mass="28476" checksum="357089AF1BC2FBE5" modified="2022-01-19" version="1">MFRAALPRRNPIPALFRYYSRSAKMSLKAISSKDAASLDKDLMEIGGWSLDQLMELAGLSVSQAVYRIHPPSSGKDVLVICGPGNNGGDGLVAARHLAHYGYKPSVYYPKQGKNELYQRLKTQLENLSVPFISDLPVAIKSADFLVDAIFGFSFGGPLREPFPTIISQIETASIPVLSVDAPSSWDIESGPPKEGPGSKFMPEALISLTAPKPCVKYYKGRHFLGGRFLTKSIADKYKLDLPEYPGIEQIVEVGVDAEGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9K9</accession>
    <name>A0A8G1R9K9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosylmethionine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_359809</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="4"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520543.1">
        <property type="nucleotide sequence ID" value="XM_025655526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9K9"/>
    <dbReference type="GeneID" id="37158928"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.90.10:FF:000023">
        <property type="entry name" value="S-adenosylmethionine decarboxylase proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00535">
        <property type="entry name" value="SAM_DCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH62621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="498" mass="55776" checksum="9C6D050F838E9C0D" modified="2022-01-19" version="1">MVYIGIPQHYTASPSSFMATPSLTINHEATQDLDSTNAFEGPEKLLEVWFAPSAQELGSAGPAGLKAVPEEIWKDMLDLVNCQVLSIVSSEDVDAYLLSESSMFVWPHKLILKTCGTTTLLSGLPRILEIAALFGGFPRATAPSRGIAVAAAPYRVFYSRKNFLFPDRQRGPHRSWRDEVRTMDKLFLNGSAYMIGKMNGEHWYLYLTEPNTLLTPPTSPRVESEDPVTETKMLQVPAAGAYQTREDQDETLEVLMTDLDEENAKQFYLDHATTVAEKRYCNFEADNDDHVDVFSNNSDMDDVSSNGSRVLPPELTTEGHALGTVVSESCGLSDVYPKSKFPESRIDAYLFTPCGFSANGVIPTPDQNTGTHYFTVHVTPEPHCSYASFETNVPHSQNGQTTQEIIQQVVNIFKPGRFTVTLFEAKPETTTADGELDHIKEVKYIERQAARRTKMENVAGYRRVDRIVHDLDGYDLVFRYYERLDWKGGAPRLGEERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA32</accession>
    <name>A0A8G1RA32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Centrin-binding protein Sfi1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_446505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519273.1">
        <property type="nucleotide sequence ID" value="XM_025659519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA32"/>
    <dbReference type="GeneID" id="37162921"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013665">
        <property type="entry name" value="Sfi1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08457">
        <property type="entry name" value="Sfi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sfi1 spindle body" evidence="2">
        <location>
            <begin position="383"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1102" mass="129482" checksum="75227FAB9A34AD8E" modified="2022-01-19" version="1">MPPVPLQRRPLSHEDPALTDEDVGLLYQVITRAERDPEVERLPYRVLFKAYDEVIAEHGVDADPGYACMRFLLKMGSKHVVGESLFDKFENLLERMGIVIEFGGEDDTYDETYPDSVPSIESRPRRRIRDTREDSTQPQPQKQLQTPLRRRASFNSMYDVGDDPTQRSFINRPSSRSSMSRIQVGKPEYPFTKPSPSPKHARVSPEAESPDRTQLMAQFIDVGRRLMSRMDFLAAQSSSAQPPPADEKPLPNGLYARSAVDRDRSERIAEASRARRSKTSSNGSDEEEEQSSSVSSRVDSISPLERPEMPPEMLYRPSLSDLLRDASTFNMYRQRAINRRLLTQWVKRAIQARQSHHNMEMVAVNRDRNTLLRQAFQTWHTIIRDRRQEERTERFFKHLEERAGRARDLFLLTKAFSHWAQLTAEELARTSAARRHILSVKYFHAWREITAVNEMKAQRFALRKPFAAWLKRTRELKQAEEKAVVISREKSKHTFYWQWFWSFCEQRAPQWYDYCLKRRSLLYWLRKFRTNRECIHEIDARNKHYAVGSVMQLWHERTQGVIAREQQVALTERRKVLEEKLIEWRAQAHLAPVANHVTKMVDTHILQAAYSQWVHRAQMLKQAREMDRQRIIRNAWTTWNDQLRCQALYARIEERIKLEAMYKWILAERYRLMQRIREQRIKREVFSVFVTNVRRTYAELLDRAEVFEEQRNEDLLRSKLERWRDQLSLQREREMVASEFYAPRLAQESLVAWRSKYQHVVKIEGWANTARYYFLATKFTKKWRVATVESAKKRRQQAYIQTRRKIKINLASKALSHWHSRSLHMAGLEQQALQFSRQRCLAMASELVPRWQEKTFNRLQDCDAADDHYARQIVGEQLTRWVEALLVYQRQEQQANNMNREHVLGQANIQLRKLSFRVFQVKSFSETAEAMKERNLRKHCRSMFRSWLEKARVKSESRDLPGPLISPTRNYDGATFEAEPNRRIFDPWYQTTTPFKTNDLAVAANSQIQMASTTPLATPNFLTSPSKRAARARAMAHVSTTPATPSYTPFASRLLRVGTVLPRTDSTRRRTGRASALGTSVRFVDEEPGSPSDGRRSSGRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAF2</accession>
    <name>A0A8G1RAF2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_482459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520481.1">
        <property type="nucleotide sequence ID" value="XM_025663100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAF2"/>
    <dbReference type="GeneID" id="37166502"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="9"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH62559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="156" mass="17337" checksum="2ADFA0B7AA86B72D" modified="2022-01-19" version="1">MAVNFPWIYPVRVIQALFGIIVLALTAYYISWFAYSSDSPNFMLFVACWTAFIATPYLALAPVFFPQFAHRIVIPAVEVITMIFWFAGFIALAVFLPPTEACHWSRCSALQAAVVFGAFEWVLFLVTSVFAVLGISRTRSSSSTKPTPNDNTHVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAI8</accession>
    <name>A0A8G1RAI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alkaline ceramidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_516702</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520084.1">
        <property type="nucleotide sequence ID" value="XM_025664861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAI8"/>
    <dbReference type="GeneID" id="37168263"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF1">
        <property type="entry name" value="ALKALINE PHYTOCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH62162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="283" mass="31636" checksum="9B3F798026726DE3" modified="2022-01-19" version="1">MASESPFWGSSTSHANFCEEDYVVTRYVAEFINTLTNLVYIFYAIYGINHLCRQSNKDVFRALPYWGLMGVGIASAAFHMNLKYHTQMMDDVSMHLATTPVLHRVMTVNTSRRTSIILAFLLGAALIGLIIHHALTDELILHSVTFVVSVTIIGVRTMQLITTRTPKDSLARRQIWGMVRFGAAIFELGFLVWLVDGWICGWLRSWRATIGLPWAFLLELHGWWHICTGVGAYIFIAVIDHLVSGEDVGAIEESFAWPAPWASRSIFAGKGSALGVTPDLKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAQ1</accession>
    <name>A0A8G1RAQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_445112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519603.1">
        <property type="nucleotide sequence ID" value="XM_025659180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAQ1"/>
    <dbReference type="GeneID" id="37162582"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000065">
        <property type="entry name" value="Similar to histidine acid phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF14">
        <property type="entry name" value="ACID PHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034929331" evidence="4">
        <location>
            <begin position="19"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="49"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="396"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH61681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="440" mass="48690" checksum="1AB5E694B826ACBD" modified="2022-01-19" version="1">MRFLTSLVVATLSSTTASYQFNSLHHLAGIAPYFSSHDPQINPAPPAGCNVTRAAYLVRHAAIYANDFDYETYIEPFIEKLRNTTQSWTNTDSLAFLANWTAPITEDHLEKLTRVGLQEATTLGVKFRQQYPDLHTDKVWAATAERTTKSAQGFITGYTNNKTHVDLVSVAQSDTTGADSLTPYKSCPAYSSSYGSTYEDEFIETYTAPIIKRLNAIAPKFNFTSSDVTAMFELCGYETVIRGSSPFCSSSLFTNNEWLSFEYANDIMYFHNTGYGRPVSPVIGFPWVNASYNLLSAETSEQDIYVSFTHREVPPTIVTALGLFNNSAYSGADNVNATMPTNEVNYDRAWKSSNILPFLGNIGIERMECSGTQNGFDEGVYFRVLVNEAVKPLIGCRDGPGESCSAEKFAEFISGKEKRFGDFGRFCGNSSALGTLDIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBJ0</accession>
    <name>A0A8G1RBJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spindle pole body interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_123436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519944.1">
        <property type="nucleotide sequence ID" value="XM_025653935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBJ0"/>
    <dbReference type="GeneID" id="37157337"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052809">
        <property type="entry name" value="Actin_polarity_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012860">
        <property type="entry name" value="Afi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245:SF1">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07792">
        <property type="entry name" value="Afi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="84"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="789" mass="87910" checksum="5E324EF98CDBC0B4" modified="2022-01-19" version="1">MSISLPYRPTDDSTLSLAATTNPSKANGHPRLSPSPSIIHRRTPSSSGNSARRRSLGNGPSALYPKPRRCKSQYPRDSPERHVEYILVASFHIDRGPIMEHQYPAAISGDESMLAELMLPDQTHVRSQDWTIFFLHKDTSADADEDDDASTGKKKKKKKKSRIGDAESGDGDSEDVDGSTEEESSDEEEGGEGPPLMYVLNLVNTKQDNSVKRGAVVKAMAICTRHSFLHIYKPLLLLALEDYFKNPYPETLASLYNAVNAMDLSLMPRLSHLERLILQASNCKDMFIEKFEQMIHQRQLEDGTPFDDEPPSPKRPAAPRYTLPRDTHEFESKIVYNDIPIPVKVPTVIWPEVVGDFSLIKLIQIFSSPHATSPQPFPIHPHLTTSGPFTHPIIVLVNAMLTQKRVIFLGHNRPSGEVAEAVLAACALASGGILRGFTRHAFPYTDLTKIDDLLRVPGFIAGVTNPTFANHPEWWDVLCDLPTGRIKISSHIEPAPVTEGLLYFQQQAAMNHHPPPSNNSDPSGDNVFMEEVQRSITNRYGENAIRAKWRAYITKFTRVAAAFEETVYGASNLYVIGPNEELSPESPSGFQADPLDPTTLRGHGYVWPDEGSKQRELMASVARIEGWRTTRSYYSFIQDIAAMYYPSRPIQKPDLHHHHDRLRALRLPPADAGAIYISFAHAVKDYAGICQLLTVTPENQAGLFYLGMGLFHPHQPVREAAVDLLERIAAHPAGRHFWAQLNRFTKLAFFRIKRERDASTQSPASGLGSESFGPQSLVGVALGDSFRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBS6</accession>
    <name>A0A8G1RBS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase, carbon-nitrogen family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_444961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519452.1">
        <property type="nucleotide sequence ID" value="XM_025659152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBS6"/>
    <dbReference type="GeneID" id="37162554"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07566">
        <property type="entry name" value="ScNTA1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039703">
        <property type="entry name" value="Nta1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750:SF26">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="372" mass="40889" checksum="7117C3AA19BD094D" modified="2022-01-19" version="1">MKVATLQFAPRLGDVDGNIKRANELLKDGKVVRGVGIGVGLDLLKPDVLILPELALTGYNFPSLEAIRPFLEPVGQGPSAQWARETAKRLQCKVCVGYPEIYTENGAQQANSTNSTETCYNSLLVVDESGDIVLNYRKSFLYYTDETWAAEGNPQQGFHQLSFRNSNQSSVESQIATSFGICMDINPYRFEAPFTAWEFANRVLDTKSELVILSMAWLTLLERDELDSLADEPDLDTFNYWIQRFMPLIRKKMGHETNFDGDDANRGKKIIIVFANRAGEEPGAEGTNPARYAGTSAIVAITQKPPSRTSGKETSSKEGDPGDDTDAAETDAPSFDTKILCWDMMGATTEGICFADTTADPSMVFGLVKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC39</accession>
    <name>A0A8G1RC39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_18631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521045.1">
        <property type="nucleotide sequence ID" value="XM_025654391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC39"/>
    <dbReference type="GeneID" id="37157793"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="108" mass="12497" checksum="6880C7D0C1DD89B9" modified="2022-01-19" version="1">MHTGLQVRDPTVHDFRDMIYGDTHWNTHRAAVAGKHWSKLLHLKKYFRFTGRVFRGSKGSGKREIMRAGLNLHPPMRRRDPAGLMRGIALPQARVPRILKQPHHVVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCX8</accession>
    <name>A0A8G1RCX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_433462</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520803.1">
        <property type="nucleotide sequence ID" value="XM_025658423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCX8"/>
    <dbReference type="GeneID" id="37161825"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF10">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034217668" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="8">
        <location>
            <begin position="26"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="9">
        <location>
            <begin position="24"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH62881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="244" mass="26439" checksum="745B0EE2556DD3C5" modified="2022-01-19" version="1">MRSFSDSISRWTAALTLLWLGLVNAHTVITYPGYRGNNLHTNGTVEETNGLGVAWKNGSYVYPYGMQWIYPCGGMATSRNRTKWPVTGGAVALQPAWFRGHETAFVYINIGWGTVPPNMSNPMLSVFEIEGPTNNPYPGTICMPQVPLPANMSVSPGDNATIQVVLAAKHGAALYDCVDITFAEPEDVEEVTKDNCFNSTDIAFKYVFASKSLTTSGALARLSSPGLNAVVPVLVMVVFGLFMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RE29</accession>
    <name>A0A8G1RE29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_464753</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520652.1">
        <property type="nucleotide sequence ID" value="XM_025662007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RE29"/>
    <dbReference type="GeneID" id="37165409"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="617"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH62730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="729" mass="82556" checksum="9EFB89512963E407" modified="2022-01-19" version="1">MSEQFTQGRAPSSLRKFTSPEMATDQKKGRLTEAKTCKACDQCRNRKVRCIMDSQQRSRCIHCIKRNETCHFTQTKRKLRSKAPQTSRNHTTSRHHIPLVNSWAEKACIQPTLSSLFLDQMLENKGRSSILRDNFALLRASDHDVTSSSLAFFTERRINSLSHRLGNDRLRELVETIESVIRSRLLAEGPSSISLITFGKPSDTEDVSLENVRLYINTYFHQLHPIYPFLDRQKFEDKVFGPNLSETLASSCAFSALYHTILALGCRYHEGGAFDPGNGRAWKLFQVSLGLVSDILIPREALMSLQALVAMSIFAMTTCCLQIDEVLLMEAARMAQSLGYHRALSNGDQRYKDTCHRTFWVIYYMEKGMCFQNHKGSMIPDHDIGCPVPDVPESVFEGHNWFLSAISFGRILSLAYTSLFSVSAAIQPPESYYAAIQNIEARLERWRSALPEQYRPGMLSQSHKPHVVPYFSSSFHQPSFKMVVLQTKFSYYGLIIALARLEIYIGRQNQSPSQEKARRLLMDTARAVVEESKNIDIAAYTPTFILAILPLGALFILFDFVIHNPMHPETLNNLSLLDVAAGHFSLLEYKSGGFVPASLLTEFAHIARQYIKDYGRNQPQHQQQEEAEMQEREDEEKGAEPCGIGSSNVESTLAFEDSEQLAQTNNPSSINDVCLQDDIMEFWEPSNYLHYPVTADTTVHGSMPENMMAASFNIQSLFGFVVPEFGHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1REY5</accession>
    <name>A0A8G1REY5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Phosphatidyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_455444</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521371.1">
        <property type="nucleotide sequence ID" value="XM_025661387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1REY5"/>
    <dbReference type="GeneID" id="37164789"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000017">
        <property type="entry name" value="Phosphatidyl synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH63449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="328" mass="35963" checksum="C3B0CF32812F4F84" modified="2022-01-19" version="1">MTAIAMLPMPLRASRQCARLFASPLVNTPLSQRGWQMSVTEARSFSAITLGSRSRTQANILRKKVGLCAIESQLVRSVGQQKRYSAQKPTDPDSSSLKKSPILSKLPRTHENIYTVPNILTFTRLLAAPMVGYFLVHDHHVAALGLFAYAGITDLVDGYIARRWNLQTVVGTIIDPMADKLLMTIGVTCLAVNGSIPVWLAVIILGRDVGLAISAIYYRWISLPPPKTMARYWDFSLPSAEVKPTTVSKINTALQLLLVGSAIALPVLPETVIDAWSLREAMTGFQYLVAATTLWSGLSYVFSRDAVKILSKEEVQKRIARAAAGKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RFJ6</accession>
    <name>A0A8G1RFJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphotransferase enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_387872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521417.1">
        <property type="nucleotide sequence ID" value="XM_025656686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RFJ6"/>
    <dbReference type="GeneID" id="37160088"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="421" mass="47508" checksum="465C23DE649542E1" modified="2022-01-19" version="1">MPTPPTNEPTRVASIMLSWHSLDLVSCTTLQTLWAGYGHICALTARATTAEAAEHLGKLCGVDSKRTAGSTFPLILKLISPPRKAAGKEDEGHLRKMLSYEVEQYFYSDVVPRLGDDIAVAKCLASTRNMHGKQGEEELRGLMATIMVDLRPAFPVAGEKRSVLSRVQVYGALDWLARFHSRSWGLSSDDRSLDGYVLPPLEEAKRRREQGKTETGNALWLNGGYTYLATRRKEYASLVEDTDSEWSDILCTASDGSSQSVAEVAALLLTPCGRQMESFIHGDVKSENLFTTTGGDEVAFFDFQYVGLGLGVCDLAKLFTCSVPLKMLVDDEDDLLPEQLEMCEGERTLLEHYHRMLLQDKGERWYDWETFVRHWETALVDWCRFQASWGFWGNTEWLEARVRSIVRDKGWREWLLRSLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RG65</accession>
    <name>A0A8G1RG65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_5599</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520617.1">
        <property type="nucleotide sequence ID" value="XM_025665488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RG65"/>
    <dbReference type="GeneID" id="37168890"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024586">
        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH62695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="744" mass="84134" checksum="0C9F1E87A0241753" modified="2022-01-19" version="1">MGSNPPPPPKDQDETSSPPEELDYYAILNLPRSPPPTEAQIRSAYRTLTLSFHPDKQPAELADSARRHFDRIQEAYDTLVDPKKRAVYDELGVQGMKQEWVILDRIAKDMRVGVRAMSGEEFRGWFLEVMKRRERAVVERMVGSRGSITIGFDASNAVSYDEEEDALYIEMPSPRPSNYALGFSFKAPLPRLGFFLGKEGEDENESDNDEGLETRKLFKEYGEETELTFNAGISGEVEQMHQEANFKFPDGRKETHLLPLPYFLIANQINLGVGASQLFGGPYSVKGLAKPPFAFMQNSVMSVNASVLPHPALETTWTKSFVPIPGAKPISVQVDVDFDRSPQRAPPRFALKVTRQIGDRRFLVSSWSSGSLLWPKPFRHFFLPLIEFGLNADTAMSVPTHPSFFQIGVVSQPKRQISPAHVEEEMEGDEEDEEFEMLRRQQRKEVGAAEAWQTNVTATPMQTTLSFVYSRNVFSGKSAYERLRSEWSSEGHHSLPEDNEPRSVRVNVETTVGLDLALGWHIEGTRQVGDFTRMGLGVGVRDMQGLVVTVSWSRLGQKIRVPISVIPFGLVDVDVAAMAVICPWLAYCALEFGFIRPRERKRHRRAIARRQKQLRRLVPKKRAESQEAIEIMTEQVQRRQAKEAKQGGLVILRAEYGYYPSKKDRESGRGLEVTDVSIPVAALVDHGQLAIPKEMAKSHILGFHDPAPLLPKMLKIWYNYHGQEHYVEAKETEDISCPMRSHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGR2</accession>
    <name>A0A8G1VGR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_408995</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509797.1">
        <property type="nucleotide sequence ID" value="XM_025657424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGR2"/>
    <dbReference type="GeneID" id="37160826"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH51875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="281" mass="31452" checksum="832D4F7E8B00E3B3" modified="2022-01-19" version="1">MSHSPPSPSPSPSPSPPFRPYRPPPPPTTNNHTTTTTDTSILPNGPKSLSSISLHAYLLGILLGLTSTLTLLPLLYGDPLYTPLWRIPFFLSSLSLFHFLEYYTTAAYNTHFATVSAYLLTSNGWTYHIAHGSAILECLLTHTYFTTRPVPLYLPPSLTTYQVAAGLFLMVLGQTIRSVAMAQAGSNFNHTVQVTRREGHVLVTGGVYSVLRHPSYFGFFWWGLGTQLVLGNGVCFLAYAVVLWRFFSGRIWREEKFLVAFFGEEYEKYRKRSWVGIPGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHF6</accession>
    <name>A0A8G1VHF6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_507915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510099.1">
        <property type="nucleotide sequence ID" value="XM_025664429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHF6"/>
    <dbReference type="GeneID" id="37167831"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034021168" description="CBS domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15119" checksum="BB6C074F9B8063BE" modified="2022-01-19" version="1">MRPGIRLVHPIDLCLAVTTGTAACTTIVRHPDRARLALLLTKSHEKISHARLPVGPRRTEDPITPETESTPDPVTAVGIAMTFDGARRAPLLQDEEDQLIGIATVRAIALRDTTVGAEATVAAAAAVLAATDNRITDMKAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHQ5</accession>
    <name>A0A8G1VHQ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrosoguanidine resistance protein SNG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_453976</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510384.1">
        <property type="nucleotide sequence ID" value="XM_025661172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHQ5"/>
    <dbReference type="GeneID" id="37164574"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF2">
        <property type="entry name" value="DUF3533 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="34"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH52462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="497" mass="55099" checksum="CDB8B0CCBE188710" modified="2022-01-19" version="1">MALYAAARQRPHRSIHDPEVRPLRLAVLKAATINLFILQLLFLGLFCYLFGSIFQQTTHIHNLNVLFVDYDGGAIGRAVRAAYQQLQGSGFPTLREQSVQAYPNPASIVSTVCNIHYWGGLYIVENASSRLSAALTGIGTATYNTSDVMTLVWNEARYSTVVDSALESNILSLSEAARIIYTTTNGPAILQTMNTSDQTAIATLADPWTLSTINIQPTTQGSRLIYNTLVVILILIQEFFYLGYLNGLYQQFHLYTSVDAHRIAIIRQLISATYTFIGSLCTTGAIWAFRYGWHVNGAQFMITWMALWLFAHLNFLVLDVFTIWLAPPVVPMALISWVVLNISSILLPFELSPGFYKWGYALPAHAIFQVMVDIWSGGCNPQLDYALPVLFAYEIVGMVLSSLGVYRRAHYAVLAEEAKKESQERLAVDAEGEAVKETPGTNGEEGPAGTADAEEGGPSETQPEGFGERIREEMSRLERVHTTRQNTGPSFDLPYTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHZ5</accession>
    <name>A0A8G1VHZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_383385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510654.1">
        <property type="nucleotide sequence ID" value="XM_025656516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHZ5"/>
    <dbReference type="GeneID" id="37159918"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="37365" checksum="7D8D31368FE812C6" modified="2022-01-19" version="1">MDSKIHVYPSFDDLPLKKDGPPGNAWGLWGPDDQIGSLNHLTDTVVAKAAKEEIKTGARVTLNWALNASSYPHLTRKTLELKLIYKAPLKHAHDDEWSFNPQCSSQWDGFRHYAYQNEELYYMGRTAEDFETSTIPNGVQHMAERGIAGRGILIDWYKWYQGKGQTVDAMSPHPVPFDQLIEALGYQGLCEDDIRPGDIILIRFGYISQYEHMSEEKRARLDALYRKQKPENIGVEPSEELLRFLWEKKVSAVAGDTRSFEVWPCTQTQWHLHEWLLAGWGMPIGELFDLEKLSKACSEANRYSFFFTSAPMNAPGAVASPPNAFAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VI62</accession>
    <name>A0A8G1VI62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_463063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511282.1">
        <property type="nucleotide sequence ID" value="XM_025661896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VI62"/>
    <dbReference type="GeneID" id="37165298"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034385586" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="22"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="88" mass="9636" checksum="3AD1CED2726A0414" modified="2022-01-19" version="1">MRFTYQALAVFISSLLVNSAAAHACESSAVWPDPANCHKFYQCNPGTEPAHKECGAGTAFNPKISACDYEQNVPSCFKDPHHPRPFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VID0</accession>
    <name>A0A8G1VID0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_379188</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Lipid-anchor</topology>
            <topology evidence="1 12">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512301.1">
        <property type="nucleotide sequence ID" value="XM_025656333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VID0"/>
    <dbReference type="GeneID" id="37159735"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000005">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034299052" description="1,3-beta-glucanosyltransferase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="511"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="14">
        <location>
            <begin position="379"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH54379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="540" mass="56987" checksum="CC283C497CAF19B7" modified="2022-01-19" version="1">MKLAVSAVAAAALVDVAVASAPAIVIKGSKFFYENNGTEFFIRGVAYQPPYDDDGTTTSAGTVDFVDPLANETICKRDLPYLQELNTNVVRVYDVDPDADHTTCMNLFADAGIYVLADLSSADYSIDSSDPEWTIDLYNYYASVVDSLANYTNTLGFFAGNENSNSVNTTGASAYVKAAVRDMKAYIKSKNYRSIGVGYSAADVSEIRTDLVDYFNCGDSDDSVDFFGDNVYEWCGDSSYTESGYNVMTEDLSNYSVPYFFSEYGCITVQPRSFSNVPVMYGPKMDYWLAGGIVYEYFQDANDYGLVTISDGSVSTLTGFSSYSKEINSVSPTGTNSASYTPTNTVARSCPTVGSSWEAASALPPAPNSELCSCMEETLSCVVKDSVSSKKYADLYSTVCGYGVCEGITGNATTGKYGAYSMCTTKQMLNWALNAYYEEQKEKGNGASACDFAGSATTTSTTSPTGTCSSLLKAVGTAGTGTVSLSAAAGTSTGDSGSSGSESSSAGVPGYMSYTATLGLGQLVVFVAVGVLSGTGMILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIJ5</accession>
    <name>A0A8G1VIJ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_452353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512348.1">
        <property type="nucleotide sequence ID" value="XM_025660808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIJ5"/>
    <dbReference type="GeneID" id="37164210"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034004803" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10262" checksum="DDD2CE1BCC691145" modified="2022-01-19" version="1">MRVLLVLLVPVACAIGHLSFQERFSAIHSNHDDSTPPSNVGHRLPLNWRLPPPEYYQRHPKRSGGGRLWWCQWPVSFGTLLIPRRALRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIN2</accession>
    <name>A0A8G1VIN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_143240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511762.1">
        <property type="nucleotide sequence ID" value="XM_025654089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIN2"/>
    <dbReference type="GeneID" id="37157491"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="98"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH53840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="487" mass="52458" checksum="B03DEA075B45EDEB" modified="2022-01-19" version="1">MSARSSHDIQQDLTISANEEKSGPSQAANSPVPEQFLPLGNEKGDEEVGLGPEAQKELSKTPTNVSHVGALASRTLTLVRTRESGRDLGPPPDGGFKAWSQVALAHFVIFNTWGYINSFGVFQTYYTETLGRTPSDISWVGSIQIFLLFFVGTFSGRATDAGYFKAILTVGAVLELFCIFMTSLCTQYWQLFLAQGVGQGIGCGLMFCPTIALMPTYFTKNRAIAIGIVASGSATGGLVFPAVVMRLLPQIGYGWTMRTLGFISLATLIPCLVFLQQRLPPRRSGPLVEWGAFKEAPYALFALGMFLNFWGLYVGFFYIGSFARNIIGVSNSTSIDVLLVMNGVGLLGRLIPNLMADRYTGPLNMLIPFSLVTGVVAFCWAAVHTYDEMYAFSAFYGLAAAGIQSLFPATLSTLTTDLKKTGVRMGMVLSVVAVAALIGTPIAGALVDRDDGQYLYAQMFMGSAILAGTLTLIAARVTKLGLTWQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIP1</accession>
    <name>A0A8G1VIP1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_462858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025661874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIP1"/>
    <dbReference type="GeneID" id="37165276"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="384" mass="43446" checksum="7FB04AE0A54845AC" modified="2022-01-19" version="1">MQPTQAVKQTPPYFWGNTSVMVGSGLQKLRSMFEAINESSTLNITHCSVVNLKLLPELQQWQIDQRHNGWILLSKGNGLARVPEKVVELLNPRDWPEPLLTRAALFGSGLFNMLCGAHDAHTLYSSYCADMIFCWEHAYHLVFPDFVKTLEQAIHDTHALVTPGGRDRRTAADLALRYMREKTSLEEQYVTQLSGKVARVNRDQALPLWICESSIWPCGVEAIARGFDCAATAHDLMQSVPLTDIVDVGSDILNSELLNALPVYDACAYNSARMLTERWSDPCAKAVMVLYPWHILNGRHNFLRRALLGYPKARKTYTCQKGADFGETFDRNYRTTGFSRPLQNACNGHVYCDHIQQQLQSWSCPKPQCRNFRFPSSSLTLQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIS9</accession>
    <name>A0A8G1VIS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_403294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025657221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIS9"/>
    <dbReference type="GeneID" id="37160623"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF3">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="256" mass="28732" checksum="ABC3E32B245D6E16" modified="2022-01-19" version="1">MGQKASTPQPGAKLQVIGAGLSRTGTASFSAALNILLDGPVYHGGTQITMGPSTEIKSWITILRDWLSGKNHQKVLAMMKDRTDGYVAITDAPGSQFVPELLEIYPDSKVICTVRDPDAWVKSMDQVAGLATLWFLRAVLLPLPGMRYFVEYISVLQAQWDKVYDNERAFDIIWHRHIAWLKEIVPEDRLVFYDVREGWEPLCKALGKDIPDVPFPRINDSKAIDQVAQYHIKRGLMRWAAAFTLVGAATAWFMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ02</accession>
    <name>A0A8G1VJ02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">R3H domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_140563</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with csx1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512107.1">
        <property type="nucleotide sequence ID" value="XM_025654070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ02"/>
    <dbReference type="GeneID" id="37157472"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02639">
        <property type="entry name" value="R3H_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12253">
        <property type="entry name" value="RRM_PIN4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000183">
        <property type="entry name" value="R3H domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034186">
        <property type="entry name" value="PIN4-like_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034069">
        <property type="entry name" value="R3H_Cip2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024642">
        <property type="entry name" value="SUZ-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12901">
        <property type="entry name" value="SUZ-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="158"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="16">
        <location>
            <begin position="302"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="244"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="474"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="536"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH54185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="607" mass="66019" checksum="5AB408EB95D9A4C5" modified="2022-01-19" version="1">MSYQQAQDMYHDNSAARSPGSQRHQQPLHRQPSRQFDAYGPMPVNLYDDMARYDTGRLERLNSSLHNNSYAYDLAGSQTWNPNGFANAQALGGIRSASTSLKTTSRTGRAGLPTTWLDQQPGIPSAFSNLGPGPLQSSAMRPEASGGPSEAEDELIPTAIVIKNIPFAVKKEQLVQLMTELNLPLPYAFNYHFDNGVFRGLAFANFTSAEETATVIEVLNHFELQGRKLRVEYKKMLPLQERERIEREKRERRGQLEEQHRPMATSQLQTQSSMSSLTSHLPATSPSPVSQRGQKLEVDLNDSTTLSYYSQLLLFKEDTARDTLVFPSNLSPVQRRTVHTLAHNMGLGHASRGSGDQRQVHVFKVAPGTNVSPPLSSIPAAVQPAETARRGLNRAATIDFSESRNDGPTHFNTLRGQPSAGFLGVLDSPGNFGNTQNLRAAKSFADLRSYTPSPVPSSASFPAALQSNGARLQHYDGATSGTSNTPTLTSAPSGSSLGMQRDDSLLVNSLSSLSLGTGIGGPNASPRRLRGMFSWEQPESQPSSAGPIGSNRSIGVGFDGQSQERMPIRQPRGPMPEKGPGFRRQNGHQSRGSDELRTSSGVEIIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ61</accession>
    <name>A0A8G1VJ61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc-binding oxidoreductase-like protein ToxD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_479738</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513186.1">
        <property type="nucleotide sequence ID" value="XM_025662967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ61"/>
    <dbReference type="GeneID" id="37166369"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="11"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH55264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="343" mass="36906" checksum="1E5B596BC5A5A699" modified="2022-01-19" version="1">MKEALVFRKNGPMEVKIHTVPIPKPGPDEILIKVVVSGTNPKDWKFPDWMDAFDGKNTGDDIAGYVHKVGKNVSEFRVGDRVAAFHDYMTPHGSFAEYAIGKVHATFHIPPHISFEAAATVPLAALTASIALFARLGLPEPWLGNKSWATKPAGGVHVYGAATAVGSFAIKLLQKADIHPIIGVAGRGIDYARSLMNSEKGDVVIDYRDGESAIVQGIRDAIPAGESLQYALDAVSEASSFQVVEKVLDQTSGAVSLVTPEAPEHLFSTIRVEFSNVGSSHADDKDFAYVWSRMISRGLSEGWLKPHPHEVTPGGLEGVETALNDLKAGKASGVKYVLRVTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJF8</accession>
    <name>A0A8G1VJF8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secretion related GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_74714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513486.1">
        <property type="nucleotide sequence ID" value="XM_025665638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJF8"/>
    <dbReference type="GeneID" id="37169040"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="282" mass="30370" checksum="ACC541E055265B5B" modified="2022-01-19" version="1">MSQPWDYIAKLVCIGDSGTGKSSLTIRLCEGRFSSSHDVTIGVEFGSRIVPVGPPASKALGGEFDDSIRNRAPSLTSSPSLPATTTASESVASGLPSPPRRVQELQKRMKLSLWDTAGQETYKSITRSYFRGASGALLVFDITRPSTFVSCTQWLHDLRQIAEDGIVIVLVGNKSDLAADESRSHQTVTRQEAEEWCRLNNITRYVETSAKSGENVERAFLEVAEMIYRNIEAGKYDLHDRRSGVKGYGATGGSNSGIPNTVTLGLDDAMRKGGSGLAAGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK65</accession>
    <name>A0A8G1VK65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_89008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512904.1">
        <property type="nucleotide sequence ID" value="XM_025665760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK65"/>
    <dbReference type="GeneID" id="37169162"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="156" mass="17033" checksum="B4770584CB0B2BE1" modified="2022-01-19" version="1">MATDSLSRSGLRGRAGWKEAVMTGGNYSLHITRPHSYKIREIPSVLLILRSGACPAPYFKVCVLLHMTGESPLLLVNARLLFFFCGGLGGEGKGNGLGCIQNLVAMGEGCVRPPQQEMVGRRGKTRNEIREDKPELETLNRLEKQADREPQPSGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKJ4</accession>
    <name>A0A8G1VKJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_452943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511690.1">
        <property type="nucleotide sequence ID" value="XM_025660950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKJ4"/>
    <dbReference type="GeneID" id="37164352"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="438" mass="48943" checksum="061D365F26B855D1" modified="2022-01-19" version="1">MLSRILRFVPLVALLILLLSTFYYLYRAIHVDTHPDLDLGLETATTTDLKTLPDSTVSQIVADTHHEITSNSTPEGRYFRIDFRSRRGINPSIIPHPSKPNTWIITAQLHEPGRREKDSAWFVELVCDAVFQDKGRTLRCIDYPFILPIAATEGNNALCSGSLAFFALSIGPHDARVFYGPDAPYTIYGSNSAVTCFGQWILDFRLLVDWPASDTITDYGFRRATELQRPTTAPYFAVEKNWFLFWDRAGNAYVHYDVAPTRAFAALTLDGSVGADLAPAAASADAACLQKYLPHMQDPDHESIHQATNSLAVTLCMRADPNCQPDDSNTVILTIFQHKRFVGFHSSYEPYVMLFWQRAPFEIYGISDKPLWIHGRGMMDEGNQTEMMYVTSIGWKTAGQKYHGYLDDVMFLAFGIEDADTAGVDVVAGDLVAGVGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKN0</accession>
    <name>A0A8G1VKN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_460288</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514866.1">
        <property type="nucleotide sequence ID" value="XM_025661711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKN0"/>
    <dbReference type="GeneID" id="37165113"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="40"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH56944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="243" mass="27013" checksum="769C5992FF308E25" modified="2022-01-19" version="1">MDKATPSPAQGVGPIYRPDGEKPTATVSKDISYENVHVLPQSPQLIALLTMIRDRRTSRADFIFYSNRIIRLLVEEGLNHLPVVEQSVTTPVGRVYLGVRFEGKICGVSIMRAGEAMEQGLRDCCRSVRIGKILIQRDEETCKPKLFYEKLPGDIANRWVLLLDPMFATGGSATLAVEVLKAKGVPEDRILFLNLIASPSGVADFAERFPKLRVVTAFIDQGLDDKKYIIPGLGDFGDRYYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL29</accession>
    <name>A0A8G1VL29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_421010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515301.1">
        <property type="nucleotide sequence ID" value="XM_025657914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL29"/>
    <dbReference type="GeneID" id="37161316"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14653">
        <property type="entry name" value="ZIP_Gal4p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH57379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="725" mass="81492" checksum="9E84057CD1562251" modified="2022-01-19" version="1">MQSERVLPARHARRRTVPRGRIMTACARCQKRKIRCDGVTPVCGGCQRAHVECVGGVSVRDISRNYVDELEARIEWLESIIREHLPYIDLHKPDEPEGRVPLDRHRGSVNRGSNPSSAPEANTSQIGNDKDDWGPARDITDQLGLVSINAEADLRYLGPSSGLFFTRFVLTGLGRRAGLAQEPVPQTGGTNFVPAELLDIQPKGLPSDLEQAQWLTQAYFQAVHGQYPFLHQPSHLELLQKAYNGIELLLPIDQFQIYMVLAIGATIRSQQLKILLSAEGYCASAIVHLDTIFQKSSVGGVQCMLLLQMYTFHNPSSAISLWTLHYHCLAHVLELGLHRNVRGSAFTEFDQEMRTRVFWCVYAMDRYLCTSLGRAIGIMDEQCDLRLPHDINDEDLRPDQPIPNQPSTPGITDMSSAIHLFKLARFSAEIKCVLYCVDRNYPPYTHPTITDPNHWQQDILHRLRQWKATIPQHHPQSPSYYLNSLLEIRYHELVMLVVRPNPLFPYPSKTLIKLCFDSALDCTRLYRHLYITSMLHYNRTIVQSLFLCTITIFYCIWAPNGLEEEETALDTVLQALKSASDILSATGEYWLEVKRTRDVLDCITKATVRRFARRLGHLSASLPSGSSGTLHDNFSGQGVSIMDLPTTTFNEGSCTDGITGNGNAGPVSVDPYYVPTQQPDATPELLSFFMDPQPESAMELLDFSWDVFGGVDDAMQEMMAGTSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLG4</accession>
    <name>A0A8G1VLG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_438667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515483.1">
        <property type="nucleotide sequence ID" value="XM_025658684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLG4"/>
    <dbReference type="GeneID" id="37162086"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="189" mass="20545" checksum="8F3D7B2E146792C7" modified="2022-01-19" version="1">MMIPSLAPNVLALELMRVPIEQQQSSPLSEDTRKMRLTRGVYAPGRALAPRTIRSNIARVTVGSAIIEDRWAPGTDLDRRPREKRAVLSRLVFLFPTYLGSFGGVVGDVDGLLRHLSGHDMRCYLSARQPRHVRGPGISVGRSYTVNGGDDAIFSLPLPSCPLRSDWSAPNLLSQICLAGIASIGGNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMB5</accession>
    <name>A0A8G1VMB5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_519349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516398.1">
        <property type="nucleotide sequence ID" value="XM_025665043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMB5"/>
    <dbReference type="GeneID" id="37168445"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF17">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_8G05690)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="75"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH58476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="256" mass="29116" checksum="FB633A0077D42F4A" modified="2022-01-19" version="1">MLKQLPCNPSDAEALATLYLQCFTTPVDQRLWPNTPEIHAWWVASFTRKLTEGLDKYHILKVIDTEKDDELVGFLEWKLPAPIQQDQPANGDENKDSAEGKDPETQELLATYPSHVGDIGLLKETLEQFRSKIGGIMGERRFYYLNMLGTKPEYRRRGVASEMIKWGTSRADKEGLETFVVSAPGARPVYLKHGFELASEGEDLGDFVPWYMVRKPTVEAKREKKREVGYAHWLLGVSAVLGVGAIIYQRVYRRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMC7</accession>
    <name>A0A8G1VMC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_520156</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515319.1">
        <property type="nucleotide sequence ID" value="XM_025665108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMC7"/>
    <dbReference type="GeneID" id="37168510"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034508304" description="Zn(2)-C6 fungal-type domain-containing protein" evidence="9">
        <location>
            <begin position="17"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH57397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="778" mass="84335" checksum="AE76231D520AB7BB" modified="2022-01-19" version="1">MKFLHIILPLVGYVLAQTSTTTTTLSSSTSSTSSTTIQIFNILPTSLTSQTTTPTPSTTLATFDASIISASSSTTILAVTCNGACPIPSIYTITAAPSTYVEHGTFIGSANGLTVTTSQSNACNITSSTQAASCSVTIGYYGTVSGGQNSSSVVSSGTSYGSGEIWYMPVTVTAGAEKLAAATQTAGGGGGGSGSGTMEESQPDVAGPPGARTACGSCAIRGKTCRVKEGETACTRCSRHGLNECDAYFAMVQRLKDERESKDKLIDEVADLREEFNTFLRNTPGAVSLSDAVIRLRNLRIESGPGGSTAPAESDLISEGVVSLEEAEGLFNMFTTCVNPLLWDGLLMQHETLDSARRSSAMLTAAILSVAALLAPDQAEVYEKCHEVFVSLSLMRRLMDPHHNSLDDVRALCIGAFYFKYMGEHLSSEAIHISSELSLDEAFYRYMRGEVADMEQVRLWCLTYICGQYFTTGRGCPPKDVGFKAIWDMTRIPIPEVASDEDRRLIALALYFDTLANAHATFYTDCRYPLKKDDMVTIRALEDAVRRCLQEYPTGTFHTDHPHSSFPQDLKNVFHAFAQFQLYSLAFRGIFPYDNSPTNFEAWTFEHCGTARAAIDAAIRVLSVIGTDSDLSLNLRYVPIYVHQMVGFCASFLLRIVGLNMGLAGSATGDIFQLKLPIDSGRIVHIGMRVARCLLTKGADLNEGHTCNIVGTSLMNMLQMLSDLHWASTSEVPVHGWGQLLQYLMTDIDASIASYPDGTFGIGFNHLLPYWFERQEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMY0</accession>
    <name>A0A8G1VMY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_370746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515919.1">
        <property type="nucleotide sequence ID" value="XM_025655971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMY0"/>
    <dbReference type="GeneID" id="37159373"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="287" mass="31205" checksum="35A7D35396950775" modified="2022-01-19" version="1">MAAKRVVVAGGNGFLGSRICKSAVARGWEVTSLSRSGEPRWDTVTGSLNRPSWASSVEWAKADMLKPETYKPFLNGANAVVHSMGILLEADYKGVVQGREPILSGLQKAFAASKPGSQDPLQRREGEPLQVKERNGQFTYELMNRDSAVALAQETLNEHVPTFLYISAASGAPVLPSRYITTKREAESIIAAKLPELRSVFVRAPFMYDESRKFTLPIALGGFVGSQVNALLGNRLDFLGSMVTKPFQVDTVGEAVMEALDDESVRGALGVEKIEALATKAWRKSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN89</accession>
    <name>A0A8G1VN89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_518352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517463.1">
        <property type="nucleotide sequence ID" value="XM_025664969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN89"/>
    <dbReference type="GeneID" id="37168371"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24579" checksum="8DCBFD1D737F12AF" modified="2022-01-19" version="1">MSTSGLLYAASRLNSPSPISSDVFNTWYNDIHVRDVLKTSGINSAARYETAAVPQDSSPWTFLALYPVPDLEFLKTEEFASIPVTSDVLPGPTHSCMDIAHFDIRRYREVGIREDSDMPSGPMSHLLTVEFDLPSHIDKADDQAVMDWFCGIYSNGVPQRVVIHEVFQAMLYPNGKPAEPPRYLALFELNGDDNVYDEAIKKIQLVANVGQWKVHKVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNU9</accession>
    <name>A0A8G1VNU9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_458159</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516879.1">
        <property type="nucleotide sequence ID" value="XM_025661565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNU9"/>
    <dbReference type="GeneID" id="37164967"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF683">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="49"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="469" mass="50375" checksum="9538F61CDB21C1C5" modified="2022-01-19" version="1">MKKQLSLDNSPEDILSAESQAGELSFLEPIQDDAVFGEIREGDTNYRNVSCIGTVALMLKVQIGLGVLTIPSCFDILGIIPGVIVLLAIAATTTWSNWMVGVFKIRHREVYGIGDVGKMLLGRAGYELFGGAYILYYIFTGGSALLSISIAFNALSDHAACTAIFVAVAAIIGFAFSSIQTLARISWLAWIGVSCVIIAGKLFIVTIGVGVQGHAPMTAGVIPESDYKLFGSPSFVEAMTAVSTITLAYAGAPAFFNVVSEMRDPHLFTRSLTICQVIVTAIYIVVGTVVYYYCGSHVASPALGSAGPLLKNISYGFALPGLCVSAVLFLHLPSKHIFMRILRGSRHLTEPTPTHWITWIGSTFSITTIAYIVASSIPVFSDLVSLVGALLATSLCFQPMGFMWLYDNWGPGKREKSMKWCLCVAWCVFIILTGFFLTIGGTYASVVSIIQSYQETGGSSAWSCADNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNW6</accession>
    <name>A0A8G1VNW6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_438991</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515065.1">
        <property type="nucleotide sequence ID" value="XM_025658694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNW6"/>
    <dbReference type="GeneID" id="37162096"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000045">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF241">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="145"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH57143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="278" mass="31588" checksum="A73CA9BED8930809" modified="2022-01-19" version="1">MQRPPSTFLTSPPPPNARCNRINFETSQPPLPEYKNLCAAVIDNAFSEEECAELIRIAESSTIPPGDFSATPTWERAMINIGGGRQALSTDSRNCGRIIYDSEDIADKLLARLLPFFKELGIDKIDNQPRVTGLAGRNKAYGMTRLNERLRFLRYEGGEYFRPHWDALYKTPDGKEKSYYTIQLYLSGQGEQDLGELKREMKRVERGEGEVNLDVKGELLGGATAFLPRYEEKERHLRVFPKTGSVLVFQQMDLLHGGDPVLRGTKYTMRTDVMYQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP97</accession>
    <name>A0A8G1VP97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-binding protein RAP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_520255</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Chromosome</location>
            <location evidence="8">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515440.1">
        <property type="nucleotide sequence ID" value="XM_025665119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP97"/>
    <dbReference type="GeneID" id="37168521"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11653">
        <property type="entry name" value="rap1_RCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021661">
        <property type="entry name" value="Rap1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038104">
        <property type="entry name" value="Rap1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11626">
        <property type="entry name" value="Rap1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0779">Telomere</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TERF2-interacting telomeric protein 1 Myb" evidence="10">
        <location>
            <begin position="83"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="TRF2-interacting telomeric protein/Rap1 C-terminal" evidence="11">
        <location>
            <begin position="317"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="229"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH57518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="402" mass="45013" checksum="C162151F12620F64" modified="2022-01-19" version="1">MPPCRLGQSWHHQLTGFGAPACNHYRHVAEAAAQVSTGYSFKYVEDSHRRGKLQNLEDYRAGPSEARPVGATNIPTRGHKIPYTLEDDQLLWDWMQPHERKPKASIRGNKIYQELAEKHPRHTYQSYRDRYLKRLKGHPRPGGMPDSTEQPAPDEPSNLATRAVQSEPRGGTTPGAASTAIQTNDKKRKRASEDTPEEGDVDNPNNPSLKTRATEVNINLPDPFISEPQTKVAAVSHSATASNGQRPSPGAKEARERGATLESEAPAKEPHQPSQPDPLFLGFPFLPSDDEPEEEDMEQDIDAWIDERLRTGKAQHEEQIHQALRCTSMDPELADRVLAILVEGKPIPDDMPGVWTPEDDKCIEGNETRGIQRVMEKHGTEAFNNRWEYLSMVREAGLLDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPC4</accession>
    <name>A0A8G1VPC4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3669 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_393056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517434.1">
        <property type="nucleotide sequence ID" value="XM_025656868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPC4"/>
    <dbReference type="GeneID" id="37160270"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022137">
        <property type="entry name" value="Znf_prot_DUF3669"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780:SF3">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12417">
        <property type="entry name" value="DUF3669"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3669" evidence="1">
        <location>
            <begin position="241"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="322" mass="37227" checksum="D9EFECE33FF26DD9" modified="2022-01-19" version="1">MTEHQTEPKYRCIGAGFCGTVWAQGNGPAIKRENGGPERSLPNDYVMHQRALDSIERLNEIKAGRDSGSLANRYQVHIPKCHRFLTANDPWWNDNIRMFPNNYEPCNAIISDHIPPFPEEVRKLLVKRYCHPKLQEEILGSVANKDCLIRPYLGRRRTQRTEVKRTPRFSAFSLRNYPLHEDQMEDLGVPLHDMQTYASMMGEALATLHWLGEIDGNDIEFVLAPSPGQGNIKNVLGEHSLWMLDFDLCRSMSMDIDGVRQAVSAYWRNDPFYPRPMANMWKDFRSQYLESSEQIIRACCIIGPEERLCLARKFIDLVEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPN3</accession>
    <name>A0A8G1VPN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(II)2Cys6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_446135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518903.1">
        <property type="nucleotide sequence ID" value="XM_025659434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPN3"/>
    <dbReference type="GeneID" id="37162836"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH60981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="729" mass="81450" checksum="296882653F6323E0" modified="2022-01-19" version="1">MGRKPNQLILEFFIRGQKLEDASNRYQHTCKACGEKFPKGRIDSLTNHLVKKCQAIPLRDRQRVLLRLHELPDLADGDQNKDVTSKGKSVDLPFTTRQNFDGLNVLAEASRQVGASDQTKRGPAYTQSVTVGGKTVVVDPALEAEGFQGHPTQPDQVEEDANNAPGTPQGSNASSVPSLPSSSQDQPQAAAASPPLPDVSLTPDPTSNARQSQLSMIAASASEMVPHGLPMDHDAGLTDGMPKMSPSWNQQLSTQEQLLFDSLHEHDPTLTAATQRAASFPRPIAMNPNSQAKGFVNEFGNSTKPTKPKVRGRFSAARRREVQEVRKRGACIRCRMLKKPCSGDSPCTTCASVESARLWKHPCIRTRIAEEFELYNANLHATLAYHDVSGIRNQIKFEHYAGRIEVTHFEESMVYVTFSGLQGHKAPASTLDPQLQALGDETQFQGPLHELYLLDSDADDLPGKIEMYIKKTAPFFYEREASDFMRPTLLLAAELSQQKKDVLLERVLELWIATHILADGELQWKTFCNPTLPPTSMHSLAQPSDDGRTPIDSVTNSESYELLCSQLRAATEKRASQLSKSVMNDLERRLLQRQQSGWFETFLVALILLNCVERTCWLFRSWDDENFAQRWPLDKRPPYYANQGDRFSDILHMLLKMRSLPPKATPRPDTGILKAVDGSDENAARWFDMIKVTPLFLEQRQATVFDPTDSRSLDLRYGAKLLPPTNVYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPY6</accession>
    <name>A0A8G1VPY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_517772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518124.1">
        <property type="nucleotide sequence ID" value="XM_025664935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPY6"/>
    <dbReference type="GeneID" id="37168337"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="243" mass="27341" checksum="A55267797F93068D" modified="2022-01-19" version="1">MGFEYERVTNARSDPELATPKDAGDEEGEALLQPNTTNTNNLSPKYYHPSHFSNHIKALLLSTPKSVLLRNTLIFFLAIWGLISLAHTLILSIIPTNTHPPTPKTCHCGNSTTEALTLGCKFDSLAAAWLPPHCRDDELTAEFERAGPNPDGSWTYYADDYHTVPMAIEEVAALADNQSARVQMTRDWHVVHCLFYWRKMFRVRDLEGVIVEPSFDHEEHIKHCIGVVLEDSWGTEARVALDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPZ6</accession>
    <name>A0A8G1VPZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIM barrel metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_466805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518154.1">
        <property type="nucleotide sequence ID" value="XM_025662152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPZ6"/>
    <dbReference type="GeneID" id="37165554"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052358">
        <property type="entry name" value="Aro_Compnd_Degr_Hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563:SF2">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="89"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="365" mass="40682" checksum="A10F1BB83DC23F20" modified="2022-01-19" version="1">MPLSTGLTRRVVLGFAPSLIESMISLQKCSLRVDVGTHRLSCLPRTGLLESPRALFSTTHLKEERQICKEGTATLQPIPLKYRIPRGTWDTHMHVVEPERFPVSANAVYQPPEHTVDDAISFESTLGIEKIVLVQPSIYGTDNSCLLEALKTLGPSRGRGVVVIDPTNIDTETLEEWHSLGVRGVRVNLKSVGKVLSEHELTETLLQHAQIVRPFGWTIQVYVSLDMVPLLEKVVPQLGVKLCIDHFGGPDLAAVEHNGESFNPYTLPGFSSLISLLRGGETYVKISAPYRLSKDEEYRDLEAMAQEFLEAAPDRVIYATDWPHTRFSGVDIEPFTETCLRICAKEPGLAERVFRDNAEEMLRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ94</accession>
    <name>A0A8G1VQ94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHY-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_392621</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518557.1">
        <property type="nucleotide sequence ID" value="XM_025656850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ94"/>
    <dbReference type="GeneID" id="37160252"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052604">
        <property type="entry name" value="Mito_Tim_assembly_helper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082:SF2">
        <property type="entry name" value="CHY-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH60635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="114" mass="13273" checksum="EC9E1AFB8E63F2E9" modified="2022-01-19" version="1" fragment="single">MCKHILNAQVAIRSPCCKKWFDCAECHQEQESHSLTKTTEMVFACKKCKKCFRKDATEFDESDEYCPHCDNHFVIDAVTPTPTLQVEGEDARIDARMLKDDRVRGHQERSIFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQJ2</accession>
    <name>A0A8G1VQJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_487528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516745.1">
        <property type="nucleotide sequence ID" value="XM_025663463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQJ2"/>
    <dbReference type="GeneID" id="37166865"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="106" mass="12084" checksum="94AB7730A5D9C79B" modified="2022-01-19" version="1">MDWTELNKVVIVAGLIGFAIVLKSEAPKLREWYRKLQEARAAQPGAPVFQQLAVIRSPPPALLPIHSHSTIELTFWENQGALGEDTRLEDSGERGDRMWYRNDAQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQK1</accession>
    <name>A0A8G1VQK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor CLF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor clf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_446096</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518872.1">
        <property type="nucleotide sequence ID" value="XM_025659426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQK1"/>
    <dbReference type="GeneID" id="37162828"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000048">
        <property type="entry name" value="Cell cycle control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000254">
        <property type="entry name" value="Cell cycle control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000306">
        <property type="entry name" value="Cell cycle control protein cwf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="12" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="15">
        <location>
            <begin position="60"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="219"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="378"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH60950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="675" mass="81848" checksum="F2DC7427A4BDE692" modified="2022-01-19" version="1">MESSRGPPRVKNKAAAPVQISAEQLLREAVDRQEPALQAPTQRFADLEELHEYQGRKRKEFEDYVRRNRINMNNWMRYAAWELEQKEFRRARSIFERALDVSPTSVVLWIRYIESEMRNRNINHARNLLDRAVTILPRVDKLWYKYVYMEETLGNIAGTRQVFERWMSWEPEEGAWSAYIKLEKRYNEFERARAIFQRFTIVHPEPRNWIKWARFEEEYGTSDLVREVYGMAIETLGEDFMDEKLFIGYAKFEAKLKEYERARAIYKYALDRLPRSKSMALHKSYTTFEKQYGDREGVEDVILSKRRVQYEEQLKENSRNYDIWFDFARLEETSGDPDRVRDIYERAIAQIPPSQEKRHWRRYIYLWIFYAIWEELEAKDAERARQIYNECLKLIPHKKFTFAKIWLMKAQFEIRQMNLQAARKTLGQAIGMCPKDKLFRGYIDLERQLFEFVRCRTLFEKQIEWNPSNSQSWIKYAELERGLDDTDRARAIYELGIDQPTLDMPELVWKSYIDFEEYEGEYDRVRQLYERLLEKTDHVKVWINYARFEINVPDEEEEEEEEERPISEDAKRRARAVFERAHKVFKEKELKEERVELLNAWRSFEHTHGSPEDIDKIEKQMPRRVKKRRKLDDDRYEEYMDYVFPADDQSAANLSKLLQRAHQWKQQQQQQGDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRH4</accession>
    <name>A0A8G1VRH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_444249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520838.1">
        <property type="nucleotide sequence ID" value="XM_025658971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRH4"/>
    <dbReference type="GeneID" id="37162373"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="76" mass="8502" checksum="97721C05A856BAC1" modified="2022-01-19" version="1">MSTPQFWSTPLRYLRWASHERPAIFYSLIIGSMGPVALVGLPPLRRALGDVDPETIPMSYPIPAGPRTFPKGYDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VS24</accession>
    <name>A0A8G1VS24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_137907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520432.1">
        <property type="nucleotide sequence ID" value="XM_025654050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VS24"/>
    <dbReference type="GeneID" id="37157452"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF21">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN REDUCTASE LOT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="160" mass="18140" checksum="1E7E1BF304770AE6" modified="2022-01-19" version="1">MPPSIGLIICSQRTPRAGPQIGTFIHNAIRESYPAEKATITTIDLAEWNLPLYNESGMPSRISSADEYEHEHTKAWSREISRHEAFIFVTPQYNWGYPASVKNAIDYLFHEWKGKPALVVSYGGHGGGKAAEQLRQVLQGLRMRPLERMIGLKFPEMKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VT51</accession>
    <name>A0A8G1VT51_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_474094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521557.1">
        <property type="nucleotide sequence ID" value="XM_025662652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VT51"/>
    <dbReference type="GeneID" id="37166054"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034625843" evidence="1">
        <location>
            <begin position="22"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="136" mass="14384" checksum="B58FEEDC20AA3B53" modified="2022-01-19" version="1">MNLKHLLLFSTTLAPISLTLANPNPNPVGPRSPQSTGLLSDLPSLIDNLKELLSQDTVDNLETIVKGAAVLLGGDTPQNLQKLLSSSNIDKLQNIIDNADLLLTTSFVNETSELIGDALPLVTDVSALLTAIMKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VT76</accession>
    <name>A0A8G1VT76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_388211</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521619.1">
        <property type="nucleotide sequence ID" value="XM_025656705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VT76"/>
    <dbReference type="GeneID" id="37160107"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF4">
        <property type="entry name" value="CITRATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="604"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="660"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="692"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="749"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="779"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="817"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="841"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="480"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH63697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1127" mass="122714" checksum="F772B62840291A29" modified="2022-01-19" version="1">MSSGILYVKDSRTDVQYEIPIRRNTVSAVDFKKIKGPGTGADRADQVAGGLRVHDPGLRNTTVVETAISFSDHERSLLLFRGYSLEQLWQSDFEDVLHLLVWGSYPTVPQRNNLSHKLTEAMLAVPDDVQRTIWSLPGTSSPLPLIVAGLSACLASHPDMIPASHDANMYRNSPEDTDRAIIQTVAAYAVVFGLVNSHRKGLRFTPPSRGRSYYENLFVMAGLVDSRTGRPDRVKLSCFRRFSILNSDHGMALTVFSALATSSSLTDPISCLITAIGSAWGPLHFGATESAKRTLRDIGEAENIPGYIHNVKQGHVKVFGYGHRSYKGIDPRVPPIRSILKDLDMSADKLLKLAERIESACSNDAYFTERGLYVNGDFYGHFIFTAIGFDPEIIPAAMLAQRIMGIMAHWREYMLTRGKLLRPSHIYTGEAEERLLPRFQQYQATLVAANQPATEGTPLLAEQPAKKPYSIFTPGQKRLIIVTAALASSFSPLSANIYYPALNSIAADLHVTSSQINLTITTYMLCQGLAPAFMGSFADQAGRRPAYILCFAVYITGNIALALQHSYPALLILRAIQSCGSSGTVALASAVAADVITSAERGTYMGITSLGIILAPSVGPLVGGILTPAITSTPGQKSSRIALPNPLTTLSLLSHRPTGLVLLSNGLLFASYYAVTAGIPSQFKETYHLNDFVIGLVFVPAGVGSLLSTTFSGLLLDWNYRRLREQFGSPILQAHHHGAFPIERARIQICLPLTLLAALSIISYSALMSLATPTLSHALVLIFAISFSITAAYNIMNILIVDLYYSTPATAMAANNLVRCFLGAAATGLVLPAMVRWGTGWTYGTIMNYHLLISLLIPLITTQIIDPLPHYPQTLHLHYPNTPWIQPGDTLQILNTKPLPILSTQHLPLHQTYTILFLDLDVLYNHTTATVILHWYQPDLIPYPNNTNILLPNPQVPTRKPAPYIAPQPPTNSHHRYLYLLYTQPPNYTFPECFEHILPPTAEARAGFDIKLFADAAGLGTPIAGNWFYVRNEVDLPTGSGSGSKGGVATSTSMSTATTTTTSMRWVECNLSSSSSSSISTSVLSTSTAIAATTTTTHRPTDSPTETTLAMSNNIDESQVQAQARLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VU73</accession>
    <name>A0A8G1VU73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_2322</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520480.1">
        <property type="nucleotide sequence ID" value="XM_025654782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VU73"/>
    <dbReference type="GeneID" id="37158184"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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                <person name="Nybo J."/>
                <person name="Theobald S."/>
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                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
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            <position position="1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
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    </evidence>
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</entry>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RAH52496.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="870" mass="96898" checksum="EE3E3DD82DD1BF88" modified="2022-01-19" version="1">MMVNQSGSDLSHASGRGAGSPRRNNEAGDTQGPPKKQRRQRPSLSCAECRRLKMKCDRQVPCSNCVRRRRAPFCNPGITDQAPSRRESEVHQRPRQTAGHDQPSQSPDGITRRSPATHESGPHHRKRWELLPQHDFSQHHNHGQAIVAAQGSADDPGRNLPPQHSGRRDEQLALLAHVLQSDSLQNSPSVPTSRNPLAGQGDSGKDSGLHNSAAQPLGAGEQSGSYGTLMLGKGGRSKYLGPTAGSEWLKESETQDISDSPPVTRAPSPKIIQEPIRSQPGRLTPGTAPIAFPFNAAASHISTRELLSRLPPREEAETLVASYYRYCAWHHDVAPRATFDKTFDRVYANSSGMSLSPQVNPQEIALVFIILAQGTMFNIEMPNYDPSTEDWLHLSELALVKGRFLSNNMVAGLQTLHLMAHLHLQLDKGGRGDNSWPLWGLVMRLVQAMGMHRDGARWNLSQDVIEERRKVFWELNAADTFQAHCFSRPCAINPEHCDVEFPAEPLHVSQEKSYSRLRFELSQLSSEILHIAMKVRKPPYSAVTDLDIRLADFERNLPFSLRCRAAFLSMPSRYPHVQAAIEASPEPSRRSMTISFQQSNLALNISETIINLHRPYYAKALYDINERTKSIYVPSFLTVIERCGIIIAIVDDIHTRFPAVSTRQWNFWYHVFGSALCLGTLVLRDPKNSMATFALTQVDAAINLFTSLVQHGANTPRYCRNLQWLSKLRARASSKIATASTAAQQADSLRDQGDPDRQEISREDREDSEDVELLGWRTRLIERAGQGRPTIRTIQLAETPTDSHESFDVLNASPHGQIHRAPQGELGMGDNIMIPGSSLPMVTPDSTNELLQDFWDPMLLQDILGGIPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQV1</accession>
    <name>A0A8G1QQV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_385186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509839.1">
        <property type="nucleotide sequence ID" value="XM_025656583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQV1"/>
    <dbReference type="GeneID" id="37159985"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH51917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="120" mass="12992" checksum="3DC3C4BF7D32BB9F" modified="2022-01-19" version="1" fragment="single">LLSTSQIDVATSTNSVSNAWRVAGIPLYHIRPFLALGTNYEYNPFASSLWEGMGLTRTMIWLYGHTDDAGWTPVGIGLDHQDQSHLRLPDGTFMAHQRHAMCGPVESGKASSSASAKTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QR22</accession>
    <name>A0A8G1QR22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_432440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825089">
        <property type="protein sequence ID" value="RAH52044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509966.1">
        <property type="nucleotide sequence ID" value="XM_025658382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QR22"/>
    <dbReference type="GeneID" id="37161784"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="26206" checksum="8B7A6073AB8477C2" modified="2022-01-19" version="1">MSSQVCHGMHNGVIQNIQADLPCGVTNSSHPYVTCCVNGDYCLSNSICVNTNDKDGDYYYAADCTDETLTDPACGTRCGGRNSAEIVYTSDGYWACCENSYGTVNCSNPSDEIFPGVAPSKLATIQYLPSTASGTPTYAVASSTSTSDSSNANTTTTSSSSSSTSSSSSASSGIGAGAAAGIGVGAAAGFVIVAAILALLYFRRRKAQNNVLPQGAGGYNGLGGGSWAQTQPVAHPVYELDRTGPHPELDGQPKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QR74</accession>
    <name>A0A8G1QR74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyridoxal-dependent decarboxylase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_508111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510019.1">
        <property type="nucleotide sequence ID" value="XM_025664441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QR74"/>
    <dbReference type="GeneID" id="37167843"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF4">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE-DEPENDENT DECARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH52097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1017" mass="114659" checksum="B44A4B6898A3DEB8" modified="2022-01-19" version="1">MGDPRNAGENITSHKLISSYFIGPRAENMEDFETNIAAILAKIKNTRLSYQPNTDGQEDVFISNETRTKLKPIRDNFTAAVGQAAETLGKQSIPFWHPRYQGHMCTDMTMPGLLGYFMTMIYSPNNVAVEGGPFTTVVELRVGKQLCNMDMPLSWGHITCYGTVANLESIWVARNLKFYPLSLYHAMREGPLGFIADDFWVNTCVGEEKLFKDLGVWELLNLRPEQILDMGEALYQQFGITSKYLEEALKPFSIQTTGKDVLENEFRIKKPAKYLLAQTRHYSWPKGGAIAGIGSANMQGVEVDMEGHISLDALEKELNHCLEQRQAVYAVVAVIGTIEEGAVDQLHDILAMRRRFQDRGLSFLVHADAAWGGYFASMIPRERMNLAGPIQQRDREEAVQKNPQLPLREDTLKDLIALREADTITVDPHKAGYIPYPAGSLCYRDDRMRFFVTWTSPYLTQGSMENIGVYGVEGSKPGAAAMAAWMSNQTIGLDPTGYGRLLGEAAFTSARLSVCYAAMHAGNPLHNRKYIIVPFNPLPKEKEGFDCLSGEVDVERRKVLDCIINRTEADIEREGWDAHLPWLRQIGSDLNINAFAINWYRSDGTLNRDLEEANYLMRRVVNRLSITSTRGDPQRVPLFLTSTQFEPAMYGQCAQNFMRRLGLDACDQDLWVIRNVDTFEKEIIEGVDWCRKRNSLEDKKITFLLRGTDKIFLDFQTSFHAATQRQQIILEATLMPKNTDLASSNDAKMKVNNDFIDLKRKNPDKVFAFESSSTVNLEALIKGIEEGPRIVGGSISAPGLDPESTIECRMEMKRVVISRPLNSTNRDDHYPRHLMPFYLYGSQNEFHISHMLLQAPNVNLSACGVTFTEALPQRVLALLERRALILTLTEYREETMHPLPETNSAILENDNFFFRPGQRFQVKIFEDHKEPNAKGPGLIDNLRFPIAREEMTLNSDVHVDVEALNKDPLEEEQVGTSWESELDQVREVLNYGHVAAMNAANAAIAANAGGAECDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRP5</accession>
    <name>A0A8G1QRP5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="5">HMG-CoA synthase</shortName>
            <ecNumber evidence="5">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_493745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="5"/>
    <dbReference type="EMBL" id="KZ825097">
        <property type="protein sequence ID" value="RAH51676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509598.1">
        <property type="nucleotide sequence ID" value="XM_025663844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRP5"/>
    <dbReference type="GeneID" id="37167246"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000590">
        <property type="entry name" value="HMG_CoA_synt_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01226">
        <property type="entry name" value="HMG_COA_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="7">
        <location>
            <begin position="178"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH51676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="460" mass="50817" checksum="6562166A9851F446" modified="2022-01-19" version="1">MAARPQNIGIKAIEVYFPRQCVDQSELEKFDGVSEGKYTIGLGQTKMSFCDDREDIYSIALTTFSSLLRKYNIDPNSIGRLEVGTETLLDKSKSVKSVLMQLLAPHGNTNVEGVDNVNACYGGTNAVFNSINWLESSAWDGRDAVVVCGDIALYAEGAARPTGGAGCVAMLIGPDAPIVFEPGLRASYVTHAYDFFKPDLTSEYPVVDGHFSLRCYTEAVDACYKAYNAREKTLKEKVQNGTNGTAQDDSKTALDRFDYLCYHAPTCKLVQKSFARMLYNDYLTNPTHPAFAEVAPELRDLDYATSLTDKNVEKTFMGLTKKRFAERVKPALEVATLCGNMYTATVWAGLASLISHVPFDASESKRIGLFSYGSGLASSLLSVKIVGDVSNLVEKLDLKNRLSNRNVLPPQSYVDMCALREHAHLKKNFKPSGSTETLYPGTYYLTEVDDMFRRKYDVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS44</accession>
    <name>A0A8G1QS44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Guanyl-nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_493554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509838.1">
        <property type="nucleotide sequence ID" value="XM_025663833.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37167235"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF405">
        <property type="entry name" value="ARF GUANINE NUCLEOTIDE EXCHANGE FACTOR SYT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="3">
        <location>
            <begin position="437"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="731"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1208"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1268"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1289"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1309"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1352"/>
            <end position="1372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH51916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1389" mass="154265" checksum="157F1A58D986B4DD" modified="2022-01-19" version="1">MHWKALRLGSSDNEAKRRSYLYDPPQSRHSEQLPRPTLSTTALAPRHSESAPRSPSLAGPDDAEHNDDYRADGPSLTQSRSRTEEPTVKPRNTGNSLLPGSGPNWRMNRFSFMRLRHASDPQLSKSYAKAEQEIPPVPSLPPPTIITTAPTSHELEEPIKRKNKFKLFPDSKTPTVEEIPPQQSTINGKSRHTAQGSTGSQAANTGQPESRVSGEEPGRLSTTSIRSSGRDQPGDSHRSSVTDARFSESSRSDQDRGDHGSSASRGIPTSEGSISSTKRFRMPRLKRNKGPLFPLPPKPTASQSLNGRAPKSIPDSSIPTSDVSDDHDRDHVSPLPSPSRSSAGVSSPRPPLLRKDSANSAHSSHSTPSIRTRKPPTTRARSSTLDSLANIRDNEPQQSPHLTSSGRTSTSTSGRKSFGDIFNIPQRLRQNSEPPFPRSGSPAARGAETPVTKSPSYPERQEGDTPTTYLERLEATVPKSVIASVLSQSNDEFYKNALRKYMRGFSFFGDPIDMAIRKLLMEVELPKETQQIDRFLQSFADRYHECNPGIFASTDQAYFIAFSILILHTDVFNKNNKRKMQKPDYVKNTRGEGISEDILECFYENISYTPFIRIEDTNPNGRHLPKPRRTLFKTASSDHLGRSTREPVDPYTLIMDGKLDSLRPSLKDVMNLDDPYRCNGTDGPPDIENLHRAFSKAAVLQIVSLRSRPDAFMPSSMENPIDSNPGLVDIKVAKVGLLWRKDPKKKKARSPWQEWGALLTFSKLYFFRDVNWVKSLMHQEESHHKEGRRRAVVFKPPLTDFKPDGIMQTDDAVSLIDSGYKKHKHAFVFVRHNALEEVFLANSESDMNDWLAKLNYAAAFRTTGVRSKGMMATDYEAQRNRMSRRGSSVSLNEKEPPSPNPEADMGEDLIVARGHLMRQKIREANEKLFVSQRQLDDLLRNARHLQVLTPVHSRARESVIMAAGRMAAKLKWVRQDIWRTRCYREVLVRDLGEGDAETPSLTEQKRLQLQIPADTTSPESKETEDEAVPEKLASPIKETTPPSPHPESIKPPSICEPPAPQPAAEELRRPSIPASFASSEAASRIGRRLSVEDLKERTKSSSPEPSNRLTREASVLSAASKLDVSSLASRASKITSPGSFDDGEERVLREAGLLEVNTSPQTKRQSLVIKEGDIDQKQIDTQETTQMDRSSRIRRSLHRTLRDAPGVHHGHLPRSKKPRDPASAAGAHEDGQGAREGEGLSRKSASFTVHGKKASIITFGSEWQNMPPEERLKLRKPTPSEEPRMSDPAITSSADSITSGSLRPGQPHSLRSLSPGTRNSAHFVEESENLYSQVQKAKSDDGFESSSKHTENSFVTADPDQSSLNEDSNAVDETTPKKLTATPEQAVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS85</accession>
    <name>A0A8G1QS85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_453554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510825.1">
        <property type="nucleotide sequence ID" value="XM_025661078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QS85"/>
    <dbReference type="GeneID" id="37164480"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="619" mass="67337" checksum="833D20B692413057" modified="2022-01-19" version="1">MKDPAPSQDDPQQRTSQRMSYQAPTRASLARSHPTLLETDNNKPPAKIMQKPSQARTRALGLRDRKALRPSLTSTASPLGSLKGSKQSPASSLSGRRSSGLAAFAAPPRRVSTRITASDLVFRSPSASQQSTEKLPPPTDTPENQLASELDSATGDIDANEALPQPSFQDILDEPDLPPTPTQLGLERPPGRPKGLLSSSPSSQQGKWGKRRNTDGREQSPSKLRKVDYGEAGESADSGLLLDRTSLPEEILTKRKLKNKLTSELQQLRNEISELETWSKDLAQDDAGDERDLTGLITLLAATGPPQSTSTASGESSISSLISSLLPFATKGPPKPPPEAPPVNPFALGEQAQTEAYLTALAPLQLTAYSETIPNSTPDLVLERHTLQFSAPPPFPSNRYKVSVTFDVNPEKQTLVSISFASQANGEDTRTPEDLRRWVDTRLANPLLKLDVTGLCWGINRYWEAMVSRAELWLHMEEQHAELISGHAKRDHVTKLKSARSQPFGMSELRQILPHLERTSMLFESKSGSLKVLVTCRLILDEWTSEPQLAPGLSVSLLSESDSGSRRKVDQESKRLFQSILNPNENNQAGSSGSGVPAGAILRATDCVLRALLGTNSMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSM8</accession>
    <name>A0A8G1QSM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_453750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510769.1">
        <property type="nucleotide sequence ID" value="XM_025661122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSM8"/>
    <dbReference type="GeneID" id="37164524"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="199" mass="22485" checksum="C89064053BDD9E49" modified="2022-01-19" version="1">MADKKTSSVTPPTNPRGIPAAPFVDNVADYVSSRSEVEPTLRSFQEMISKYQFMEVNTQRRAQGLRDKIPDIKKTLEMVRFLKLRRENASASALETNFELNDTLYARATVSPADTEEVYLWLGANVMLAYPIEEAESMLDEKLAAAQKSLANCEEDLEFLREQITTLEVATARVYNWDVVQRRKEKAEGKGDEEGEKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT38</accession>
    <name>A0A8G1QT38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_165207</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511009.1">
        <property type="nucleotide sequence ID" value="XM_025654258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT38"/>
    <dbReference type="GeneID" id="37157660"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="525"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH53087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="541" mass="58646" checksum="611BFEFF8F6077EE" modified="2022-01-19" version="1">MAAKASPTAVSANSGAEEVGLSDPGDSQLLAKMGYKQELRRQYSTVQIFAVAFSIMGLVPSIASTLSFSLPAGPAGMIWGWFTASILIFFVGLALADMASGMPTAGGLYWWTHYFAGKKYKNALSFLVGYSNTLGLIGGICSVDYTLALMILACVSITRDGSYSASNGTIYGVYVGLILVHAVVSIYSGPIMPRIQTFCIFINIAIIIATVIALPVGKVTRGESLNAGTWVFGHVDNESTWPTGWNFILAFLAPIWSIGFFDSCVHMSEEALHAAKAVPLGIIWSSGCACVFGFLVLSIIASVMNPDVNATINSVFGQPMAQIYYDALGKKGALGFMAVLIVIQFLIGLSLITAASRQAWAFSRDGALPFSNYFRHVSRRIRYQPVRAICGLVAVSIVFGLLCLINSVAANALFSLFVASNYVAWATPILCRLIWGKERFRPGEFYTGFMSRPIAIIAVLWLAFGLMLSMFPTTGPNPSPSDMNYTIVINGFVWVACMTYYFLFARKWYTGPKMTVDGVEEEKPESETAEKRDEAHTSASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTC1</accession>
    <name>A0A8G1QTC1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_197629</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510453.1">
        <property type="nucleotide sequence ID" value="XM_025654490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTC1"/>
    <dbReference type="GeneID" id="37157892"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF40">
        <property type="entry name" value="THIAMINE PATHWAY TRANSPORTER THI73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="71"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH52531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="513" mass="57309" checksum="4EF4378F8F7E8EF6" modified="2022-01-19" version="1">MRSMAETMTVSTSEKDDKLVATSAVDTESKVDGHVSLGQADAALEYLHAGEVATFSDIDEKRLVRKIDWMVVPLMWAIYFLQYLDKILINYASVMGLLDDTGMRTDQFSNLALAFYVSYLFFELPTGYFMQRLPTAKYLGMNVTLWGLLTTLNCVAKNFPRLVVLRVLLGCFESAVAPALILITSMWYKRNEQPKRIGFWYLGTGTATILGALVAYGLLFYEGDKFYSWQIMFLIFGLITIAVGITVIVVFPDNPMKSRLSHEEKLMVIERLRENRTGIENKHFKWEQFFEAFKDPQTYLIAIIVASGNISNAAISSFSALIIKNFGFDTKETELLTIPGGVVSVISILLGTYLAGRFDQRCFCIIGILCSGLLGGCLMAFAPSDNKGAKLAGNYLTNCVGSALPLLYSTVGANVAGHTKKVTMNAIVLMAFCLGNILGPLSFRTEDEPEYMPAKVAIVATVSVAIVFTVALKCYYIWENRRRDRKCAGLQHEENSEFLDLTDKENLEFRYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTH4</accession>
    <name>A0A8G1QTH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_431935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510211.1">
        <property type="nucleotide sequence ID" value="XM_025658356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTH4"/>
    <dbReference type="GeneID" id="37161758"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20307" checksum="16EA0095FEA9FD53" modified="2022-01-19" version="1">MPDFYPALRNRRNNELARLAEEHLQHDLRSEDRDALTTATQKVAWWTTIGSAVGLGLGLYAAFRLRSSRKTFFEVFRAREKPTHVVFAGGRSEPIPDITPLLKPTTLGDFTTYFFASAGGFFLGGELGFLGGAWSGSRCITADPDRRQRIETAFRKFRAEVLRKEADELDRGLDVSDQMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTI2</accession>
    <name>A0A8G1QTI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_407601</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510464.1">
        <property type="nucleotide sequence ID" value="XM_025657365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTI2"/>
    <dbReference type="GeneID" id="37160767"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="462"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="537"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="151"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH52542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="607" mass="64212" checksum="772285612B598265" modified="2022-01-19" version="1">MRQAISSRTSGAIRRDVQIAQASAVPYSSYGGSSSTYDDGQWYGGYSSGNSYGQQGSNGQQSGQSSDMSSGSTGTGSSGSSGASYSSGGQGGAAAQASPVASTENSASSWSEGSPANSAQANADSWTSQYVPNSPSPSVVSATWETSALPTQTDSWTSMTSTTSTTSNSTPSRSSTTETETPASTTTAASAAGTSHGPTPLSTKLAIGLSVAVAVVAILGFFVWSLHRKKRALQKAIAGNKGRDEKPDPSPPQPSMMKRCASSFCNGVSTIKFKSTRSRLRCSSVRLPGAPKSEYKPIKDLALKVYANGRGMLRTAANIARSTWQKSHVHVPRPASEYMHDPNSVVRDGFRQIHRSYLSLPQARSSNNNNKDNKDIHPALRGLHSSTETLVGADMGRIKEVTVSNTPPREETGRIPEANVATVETVSRGTSTNSSSPTVSRSPTIEVPTIEIPTSPGAPPISLARVYRVDMDFRPVSPEHIGLKEGQTAILHLVYEDGWALVTVLETNKEGLVPRACFSAQPIRNQAQYLGNNISISTDHVPRSPRPATPTSPCESTSDGDLGRFYSNCVSPELPPMDDERPQTPKLKSLPSIASFLKSPPSFKSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTY9</accession>
    <name>A0A8G1QTY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_155691</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511541.1">
        <property type="nucleotide sequence ID" value="XM_025654184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTY9"/>
    <dbReference type="GeneID" id="37157586"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000308">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF6">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="99"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH53619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="496" mass="52771" checksum="092278C5C5A614C6" modified="2022-01-19" version="1">MSFSALGTLVDIQSPPLITSPAAVVRKDKQGIPHAPSDHELEGLRRERSQQTADIPSQQTLGLQTPVSPGELESHPTSPGEEAVDSIPAIQSPPMTKWRLLSACLMNFAGGLNDSAPGALIPYMEKDYNIGYAIVSLIFVTNAVGFILAAPLTQMLELKLGRSKTYSLATSLTTAGYVILVCKPPFPAVVASFFLLGLGMAVNLALNNVFCANLVNGTAALGALHGAYGIGGIIGPLVATALASHGVRWSYFYSINLAMSLINMVFSAWAFRKYEKEPPTQLLTALHRTTSQQTPGPVQPARTHLLKQALKSRPTLLGALFIFAYQGAEVSISGWLVSFLINYRHGDPSRVGYVSAGFWAGITVGRFVLSHPAHLVGEKLSVILLVLGSVAFQLMTWLIPNIIGDAVAVAVVGLLLGPVYPCATVVFSKLLPRSMQTSSLSIISAMGSSGGAVSPFFTGLLAQTVSTYVLHPICIGLYGVMLMGWLSLPRISKRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUH4</accession>
    <name>A0A8G1QUH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_480099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512503.1">
        <property type="nucleotide sequence ID" value="XM_025662985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUH4"/>
    <dbReference type="GeneID" id="37166387"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034848373" description="Mid2 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH54581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="26588" checksum="3ED1C823B34BFEE7" modified="2022-01-19" version="1">MMLITLGVFFAKFGKSAAKSCYAPDGTPVEDDIYAPCIAIEGVESMCCRINDTNPDECRADGLCYTNMTGYAGYWRDFCTDETWDTPNCLSKSICNTTAGGNSSWTYYMTPCGGVDYCCGDDPSCCSGDSVFSIKDTLVTIGGVATTTVTATSSAEVNGTNSGSSDESTKLAIGLGVAIPLTAIAGAMLGAGFLWGRKITQRKWLQATNHEGTAGPLLQPILQQGIVPNYHQSYPHEVSASQLSPTELPGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVA6</accession>
    <name>A0A8G1QVA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_500486</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512415.1">
        <property type="nucleotide sequence ID" value="XM_025664127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVA6"/>
    <dbReference type="GeneID" id="37167529"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF172">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH54493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="434" mass="48838" checksum="1EC5FD8E67C286E8" modified="2022-01-19" version="1">MPSRTDSPLDIAIIGAGLGGLSAAVALRRQGHRITVYERYDFAGEVGASLSAASNGSRFLEQWGVDVKAAKPVVLKKLIMHDWETGAIQNEYGLGDYKAKFGTEYNNFHRIDIHQQLLKSAFDEPGEGTPCTLKVNHKAVSLDAEAGRIVFENGETASADLIVAADGIRLYTYINMNKIQSQSRLEMGITPEFTMSTSCCYRCIISADKLRSLGLDDYIDNEAIEYWGGFGINKIVMSPCSNGEVVSCYCFYPAEYNNLRGDGWNIAATPEQLVDTFPGLDERMKLLMMNAEDIKMWRLYRHQPYPYWAKGKVCLLGDAAHPMMPDQSQGSCMAFEDAGALGFIFHRTFREEYSVAEGLQLYERLRKPRATKVQEASFRAREDLSERIGWSSSTDRPGKLTIEEVCGYNMRTHLEELKARYTVDLVFRWLCVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVC5</accession>
    <name>A0A8G1QVC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_461745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512983.1">
        <property type="nucleotide sequence ID" value="XM_025661807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVC5"/>
    <dbReference type="GeneID" id="37165209"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070:SF1">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27526" checksum="BD4336D5DEF81294" modified="2022-01-19" version="1">MDPKKHQKDLDRLARIRENQRNSRARKQQHTRELENKLAALQEQARHRDVEHRMAVQRLEAENRKLRYLLTRSGLSSELLEQYLQIDDPALTEKVAIPKLRSTEAQCQSQDSSACVPKARNAATGALQSIEPGLSSPGQSCDRVTKPRSEIVQAASDIEVPVRDQSVCGCGPGEAVESWPSSGDVLNTTLCAIADELIDQYNTRGVELSEIRRKLWAGFSKGLTTEEGCRVQNHILFQVLDEISNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVL9</accession>
    <name>A0A8G1QVL9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2 finger domain transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_499882</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512595.1">
        <property type="nucleotide sequence ID" value="XM_025664088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVL9"/>
    <dbReference type="GeneID" id="37167490"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF18">
        <property type="entry name" value="NICOTINATE CATABOLISM CLUSTER-SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="4"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="60"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH54673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="833" mass="91312" checksum="79C46DF475BED49B" modified="2022-01-19" version="1">MKSHVCHWPNCGKTFTRAEHLRRHALNHDQARQGYTCERCSVHFHRPDLLNRHLMRHAKRDEEAGGPGQGVLETRKRTRRAGDGSIITRPPKRQSRARASHSLPPSSSASSSSISVTSAQDYGAPVSPPTSASDPSSMSLDEPDPLLAPMMPSGPFEPYVEPIPGQFDAADGSWSLGLDGMGDFFSLDTATDFNMPFAATHNYNWLFDVASLDDAFPPFDLPLGPDMVTFAEDALPIDDPKSYLERDGSSVLLQAASFVERSDPLVFSAPILDPQPDTINLDWMDAPSFLQTTPQPHLPILTEEARQGILNLIAQAPPLTIDGQPTPLDSPLLSLPSLQSYSDLFFTRFNTTYPLLHQPTFSPSTTTPVLLAAILSMGATYSSREAHQLAVGIHDSLRNQLFCHADFSPQPDLWVLQAMLLIDCFGKMRAGPKQRERAQLFHCVLIKLIRRSDCCAIRHTPNPATATTDTDIDTLWHTAMHDEQKKRVALHCFMWDTQHAVLFSQSLCMSAFEIRSALPCSQSTWEACTASDWAHHASMEPPPRMFLSVLKGYITPSAMARPRDLNTLARIVVLHGLMSVSADLKRRDQTTLRAETPERVGAWTRRMGRSYDLWKVDFDADCLAMKLNFGQHPGEDVGGSRRGGAGGVFTGLKMAACALYRAAWLALQVEILDLQVAAGAGRILGRTVTEGDRERSRRGLRKWLLGGGEGALGAARQAAKLLEEAVLSLHDWEQTDAFHFPWCLYLATLTCWAFHGGVNGDGDGGGSGSGERVTTDLASLIVAMTTCGSLGDMAALGGKYDTRGLVRTMAQQLATVRWAVVHDAMKVLVNLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVN8</accession>
    <name>A0A8G1QVN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KR-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_500524</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512420.1">
        <property type="nucleotide sequence ID" value="XM_025664129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVN8"/>
    <dbReference type="GeneID" id="37167531"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF28">
        <property type="entry name" value="SYNTHASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Polyketide synthase-like phosphopantetheine-binding" evidence="4">
        <location>
            <begin position="218"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH54498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="298" mass="32726" checksum="FE58CC243A432223" modified="2022-01-19" version="1">MKQAHGHLKAIFQMSMVLRDQSFPRIMKSEWDTAVDPKVKGTWNLHQASRSINADLDFFVMFSSLSGIFGQPGQTNYAGAKTFMDAFAQYRFNLGLPACAIQIGAVEEVGYVAENEGVMQRFAHTGGSESAISEQELLEAVNSTSGYFYLGVRSNMCLNNPGERSLWKGDVRMAAFHNNEDSNSTAAGFSSDDLQSFITKAKGDADLLGQSESAQFLAREIGRKVCDFLLKPEEELQTSSSLSDLGLDSLVAIELRQWWKSVFGFDISVLEMMGMGSLDALGAHAAKGMLRLFHGVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVX1</accession>
    <name>A0A8G1QVX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_503390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511878.1">
        <property type="nucleotide sequence ID" value="XM_025664229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVX1"/>
    <dbReference type="GeneID" id="37167631"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="38"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH53956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="431" mass="48806" checksum="0E0515B3ADCBBDBD" modified="2022-01-19" version="1">MSIGRDILCQKLQVLLDRRRAEGRLYEPGSPDEFEGTVDFGSNDTLSLSASGLLTEAFLHQLERHPHFTIGTNSSRCFEGTKRFILDIERDLAHFHNSEDAIFFGSGYDANSAIFSAIPQPGDFIVFDELVHSSIREGMRLGRAKSISFRHNDSLSLRQRLEEVRDQDSEVAEGKRLVYIPIESIYSMDGDVAPLHEIVKVAYDTLPRGNYILSIDEAHSNGIIGPHGSGVVSLYGLENEFSIRLHTCGKALASSGAVVLCNSTIKEALINYGRNIIFTTAPSFTTVAAVRAAYEILATQEGHRRQQRLQKNIWYFYWTLTKHPQWEDIKQRSILTLPTEKTWYTRPFKSPIVPIITKPKQSHNLCKRLRRAGYWVNSVDHPTVPKGTGRVRLMIHADNTREEMDGVIQLIMNWATEQYQPVESVQIMAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWE3</accession>
    <name>A0A8G1QWE3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_441003</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513030.1">
        <property type="nucleotide sequence ID" value="XM_025658792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWE3"/>
    <dbReference type="GeneID" id="37162194"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000110">
        <property type="entry name" value="PPS1p Protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053239">
        <property type="entry name" value="Dual_spec_PTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="501"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="574"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH55108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="688" mass="76915" checksum="E7EEC7B7416AD562" modified="2022-01-19" version="1">MATVVVQQQTLRHSTPPPTGLTPALSLNRTSSPIPNKHIPVCPTGPSPINAHAPSPAAKDSSNEQTSSLLYPPDKSRRLTNSPTVYTIDLKTLSASLEHWAAQPLPNPESMFPWLHGLHPDNHLQLGFFTKGKRSLRRTPRCWRGITIVKVGGNLSSCRIKGAVAPEEVLAPSGVEFLAVDPREGFSVRNFQIQTAKLAPLSDIIVYGENSATQQQILDIARRMATAQHNWRIKNDPDRNFPAYNTFVLDCPFSEVEKRAPHLVAINSSGQLTGQVVDFFQWERLEMCEMSKASEISTNVWLGPTPDYLLRPGSCGPPPTENFDLLIEASELASIPGPRFLANLNKQLEEGPQKLEFPSSGSILLPSGETREIDDLVNTVRWIYYLANPDEPDQKADADGDIPMIPLTKTARKILIHCPDGYTESSLLAIAYLMFAEGISAPNAWLRLHCEKKRNFFAYPSDITFMSGVQARLLQESPATRSHKIRSLPDPAWFRYCDGSLPSRILPYMYLGNLSHANNPEMLSALGIKRILSIGETVTWNNDSAKADEKIILHITDVQDNGIDPLTRAFDRCLEFIQRMLIRTGHLGQGKQDGMATLVHCRVGVSRSATICIAEVMASLGLSFPRAYCFVRARRLNVIIQPHLRFVYELLKWEELQLQKRNKPARRELEWATVAREIALMNKPYSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWH5</accession>
    <name>A0A8G1QWH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_142578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512208.1">
        <property type="nucleotide sequence ID" value="XM_025654083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWH5"/>
    <dbReference type="GeneID" id="37157485"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="73" mass="7958" checksum="715148A6C253A784" modified="2022-01-19" version="1">MQEGDFIPRRILENIAVGGNVCLMMVHKVNADEVSLLHTIICGRESPARRPPDCNAYQGNHSGERHGADESGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX40</accession>
    <name>A0A8G1QX40_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7907 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_407055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510897.1">
        <property type="nucleotide sequence ID" value="XM_025657352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX40"/>
    <dbReference type="GeneID" id="37160754"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057229">
        <property type="entry name" value="DUF7907"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25484">
        <property type="entry name" value="DUF7907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034553695" description="DUF7907 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7907" evidence="2">
        <location>
            <begin position="29"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="173" mass="18953" checksum="B60DD2A2594F6A87" modified="2022-01-19" version="1">MKFLASLALLASTVAAGPVLYPRQSSNSTQSFYLKTSGATNDDHNNLYIYAYHTGAGFNDAVLTSDVGTASPAFLNGTHTQFDLGTSFPWGFKMGVQNNYAAWESVQINVGYGDDDFSIGSTGLEWSAQDGFGGWLVCDWYHNAPQLFYIYRYEEPTIPDSCSTVDLTPEYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXB6</accession>
    <name>A0A8G1QXB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">N-alkane-inducible cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_83630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513275.1">
        <property type="nucleotide sequence ID" value="XM_025665716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXB6"/>
    <dbReference type="GeneID" id="37169118"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF17">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH55353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="498" mass="56797" checksum="4DAA013FFA913420" modified="2022-01-19" version="1">MDIQPKLIIFLLAALVIASESFRRYLKRRQFARQHGCQPVARSFSKDPFLGLDTILGTMRTRKEHRILERSCNLFRTLGNTFTVKELGRSAIVTIEPENIKTVLSLNFNDYSLKHRYEAMKPLLGEGIFNTDGHHWATSRALIRPSFAREQVTDLRLLEELIQDLFALLPRNGSTVDLQELFFRYTIDSATEFLFGQSVGALKEGYSEAGFAEAFHYAQMAIPMRGMLGPLGVIFRDRKAEECNHICRDFVQRFVDEAVYAAATRKEDESPETKRRYIFSHELASRTSDKQRILDELMNVLLAGRDTTASLLGNMFFVLAKNPAIWAKLRAEVETLQNRPPTYEELRGLRYVQCCVNESLRLHPVVPRNEREAEKDTVLPVGGGKDGLSPVFVSKGTIVGYNIYAMHRRPDIYGPDAEVFRPERWEDGKLQPRWGYLPFNGGPRICIGQRYALTEVSYVLVRMVQEFRGLESRDPGPWVEGLGLTLCSRNGARVVLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXW5</accession>
    <name>A0A8G1QXW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">agmatinase</fullName>
            <ecNumber evidence="5">3.5.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_425456</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>agmatine + H2O = urea + putrescine</text>
            <dbReference type="Rhea" id="RHEA:13929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="3.5.3.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="5"/>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513560.1">
        <property type="nucleotide sequence ID" value="XM_025658077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXW5"/>
    <dbReference type="GeneID" id="37161479"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000006">
        <property type="entry name" value="Agmatinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034722345" description="agmatinase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH55638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="422" mass="46049" checksum="9C4D37DEFA6833C8" modified="2022-01-19" version="1">MKSLTWAACLALAGTAFAHAHHDHEEVPEHVREELLRKWDQEFTFSGIASFAHLKPVKCLIEPDERYDIAVIGAPFDTAVSYRPGARFGPRSIRAASARQMAGTSYNTRAGINPYASWATVKDCGDIPITPFDNGVAERQMYEAFLELGSRPALTTASSKYGTKGISAGKSKLVTLGGDHSVALPALRALYQIYQKPITVLHFDAHLDTWNPVRYSAYWTSEQAHFNHGSFFHKASREGLICNSTSAHAGLRTRLTGVDDSDYTNPGPEQGFMRIHADDIDDLGPMGIVNRIIERIGLDSDQPVYLSVDIDVLDPATAPGTGTPEPGGWTTREFIRILRGIEKLNIVGADIVEVSPSYDNKGETTALAAAQVAFEIITSMVKAGAGEELGGWYGRKVMPVEETVVEEAAEEAVEKKEAKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY17</accession>
    <name>A0A8G1QY17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_480193</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512626.1">
        <property type="nucleotide sequence ID" value="XM_025662992.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37166394"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF13">
        <property type="entry name" value="POLYKETIDE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="8"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="919"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2147"/>
            <end position="2227"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="919"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1084"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1269"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="952"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH54704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2239" mass="244036" checksum="9E8D77E1B82DA15C" modified="2022-01-19" version="1">MTLTNNSQTPIAVVGMSCRLPGQVRTIDDFWTLISRGRDAWCPFPSDRISSAAYYHPDPQRKGCFNQKGGYFLQEDLSQFDAPFFHITQQEAIAMDPNQRLLLECAYEALENAGIPYEAISGSRMGVFTGHCASDYRRSAFRDLHALPMFDATGNQESIQAGRLSHFFNLRGPCMTVDTACSSSLYALHLAVQSIRSGEADSALVSGTRLHVNPDETVSMSMMGLYNEQGKTFAFDDRAVSGFACGEGLGCVVLKPLDQALEDNDPIYSVIRSTGLNHDGRTVGLTNPSGEAQEELMREVYARANLSPEETGFVEAHGTGTKVGDPIEVGAIHRVFKDGRTKRAPLYIGSAKSNFGHLEPASGIVSLIKASLMLHRGFILPNANFERANPAIPLDQWNIRVPTSLRPWPQGKKYISINNFSFGGSNCHVVLERPPRPCGQPPDTSNDAPRLFVLSGYDDEAAKRIATNLVFYLEQHPGVFERRLVHDVAYTLGERRSHFPWRIAVTASSTAELVEILNGPASIPQRARLGAGSSSAIAFAYTGQGAQWPRMGLELTGTHPVFAASMEEAARALEGLGADFSLFEELRREAAESRVNQPQISQVVCTAVQIALTDLLASWGIQPRMVVGHSSGEIGAAYAAGAISVSEAIALAYHRGRLAAQVRVRFSDLNGCMMAVGESAEEVHRTIKQLQLEKDITVACENSPRSTTVSGDATAMDLLAKELEARQTFHRKLHVDVAYHSPHMQLIAEDYTSAIQQVAPSTMKENVQFYSSLLGEKVEQPGVLGASYWVDNLTHPVRFSTALGQLCAESKPDIIIEIGPHSALQGPIKQILQGMQNTHIQYFASLARNDHATKAALQLAGRLFLAGQQLNFRAVNPIHQGGSVPTVLPSLTPYPWSNRSYWHEGRVAFNHRMPRFPRHDLLGRMEASTREDEQPIWRNSLSLDSVPWLRSHRMQSMTTFPMAGYVSMAVEAASQRAQLRGLSQSQIAGYRLREFQASSAFTMEENVEYETWFSLSSFTEGTRSYSSDWDEFRIASWTATRGWREHCRGLVGIRRQESSTNPVSQRRSFHAALQRRHEATQGDYRPMPLEAFYADLEERGAGYSDVFTLHPESGLAVQKAGAGCSYARGNVSVPNTAEAMPSGHETPSIVSPPFLDMCFQLTFPVLGAKYGRIPCLYMPISIQEMEIAANFPAKPGAIVEAHALGFPADASNLGPTEFTVDAWDPNASTEQPVLTILGLRSTPMNTDISIDATPHPWCYTVQWAPFSSAGEPNGAEANGNDHTNRNGQANGSGEGHGNGVAHANGSHHASLADQTTTVIITERNRSDPLISSLMKTIEAFTEHEVTISPLSGVQMSSTNRYICLCELDTPVLQSLTPESFKQVQNLLLNCSYCLWITSGAYLAVDQPELNLSQGLLRSVRSETGNAVVSLDLDPSSRQDVAGRAQLILDAFKASTSTLLKAASDEEAPLSDYEFSEVSGRLMVPRLAEQSELNSALFRETHPSHSYAQDFDQGTDRRLKIAVGTLGALDSLYWTDDPAQPLGDNEIEIKVACTGANFKDVVIAMGQVASPYLGIECSGTVARVGAKVDTLKPGDRVGAMSQGAYSTYARCPATSAAVIPDSMTFETAASIPVTYSTAYYGLVELAKIEAGESILIHAAAGGVGQAAIQLAQLIGAEIYATVGSEEKKQMLVDRYCIPASRIFYSRNTEFGPCVRDATGGRGVDVVLNSLAGDFLRETWSCLAPFGRFIEIGKRDITSNTRLEMSRFEYNCTFSSLDLTLVAEQKGKVLNRVFTSIMRMFAQGRLSPVHPVTTVGITEVESVLRKLQSGKTTGKVVVDHRINGKVKATHPTPSNDLLPSEATYIIVGGTGGIGQSITRRMVQRGAREIVLLSRSGTVTEAIQKLIDECQTVNASIHVKQCDVSEISQVKAMIAELQKDLPPVRGVIHAAMVLKDTLFEQMTFPDWDAVLRPKVAAAWNLHYSLLHQPLDFFVMLSSVSGIIGNRGQAAYAAGNCFLDALARYRRQKGLSAVSIDLAAVADVGVLSNDAERRAEVMKNLKSSNALQEVEVLTLVELAMQGRLTALNVEQCITGVHWAPPTPTPYYASDARFTQLVEAARQLEGNDAANGSTTKSLSIGQQVRRAANLEEALEITAIGLRDKLGDILMLPREVLEAHTQSTPIATFGLDSLNAIELRNWIGKELMAHMQVLELLSAGVLGDLALLVLKKSTLEGAWKGEISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYE1</accession>
    <name>A0A8G1QYE1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="2">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_379131</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="2"/>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512357.1">
        <property type="nucleotide sequence ID" value="XM_025656330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYE1"/>
    <dbReference type="GeneID" id="37159732"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF76">
        <property type="entry name" value="TERPENE CYCLASE_MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="5">
        <location>
            <begin position="99"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="4">
        <location>
            <begin position="401"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH54435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="739" mass="84167" checksum="F9560C81094AF986" modified="2022-01-19" version="1">MASKYTLRIKNRVSGNCPSNRIGPSHTKQTDTDGWHLVATQDLGRLKWVYIDDEERKAHPQDGTTKFFLDIPTSNANSCPAKTASQAIYKGVQFHSNTQVRDLGCWAADLSCIFFVTPMLVMAWYITGAQIDEAHVVELIRFMFNCQNPDNGGWATYLEEDPSPMGTTLVYIALRLMGVPAGDERLCKAREFYLSHGGALYLPAWAKFWLAMLGLYDWAGTDPYPVEMWLLPKWFPLSPWNWFIIPRQVYLPMCYLSSRRFTLPTNDLLDEIRAELFPQKFSSVNFAAYEGVVRPSKRHQAKSWILHILNWILTNVWNPWLCPSVLKNKAEERAWDILLNMDNASNSTGIISMDAWLNMIAVYCGEGPDSPTLKHMQETSLEYLWMGSSGMQSMSIHGGHAWDTSLALQTLVYTGLAEHKDFQHNAQRAYEYLIQQQLVNDWDDDSICHRPSRLGAWSFTTRYHGSPCSDCTAESLKAILMVERKLGSRQMKEANLRLSVDNLLMIQNHSGGYSSFEPIAAGNWLEYFNGTEMFGQVMTEHDYVECTSSCVTALALFRARNGEYRRNEVDRAIERGVKFVETSQRDDGSWMASWGITFTYGAFFAMEALHHGGRTYENSSVVRAGCRFLLDMRESDGGWGETLESRMVGAYVHAPRSHTVQTAWSCLALMYAGYPDPEPIKRGIYLIISRQKPNGKWEQEYPVGSGMLTCHIQYHNYIYSFPIRALAMYEKLYGNGPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYV2</accession>
    <name>A0A8G1QYV2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_479161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514166.1">
        <property type="nucleotide sequence ID" value="XM_025662937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYV2"/>
    <dbReference type="GeneID" id="37166339"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SUN" evidence="6">
        <location>
            <begin position="546"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="380"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH56244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="754" mass="83002" checksum="2C494609AE1DE5AC" modified="2022-01-19" version="1">MPEAARDLIISIYHRLSLPSPLSGEACTLCALANKIIEPILSIELPMPTRRGATRRAGSTPRSDIGSASTYFQSKLGPEARTQALPNLPTKQSFAYGSAETPILPRELKIQPHMDLTEMADAIDKGIEDAKDRQLKEKETTQDKSRRQKSPSISRSPVRRSRREPTPDELQLLDNLREATKSPTPIRGNYSNNDQSTATPTPPIPHTLSTASSPTQPLPVPRYPHVPADNLYPSPMGRFGPQLHDGPPLGSSPLPDNSSLYSFTVERAINSDELTRTLSDGKNIKAPPRRFSGLAFNEPIHEEEEPDSRLLKTKSRSPSLQPSLEEFTIEPSPEPEPQLEPESVHEPSPEPTPTPEPEPMPELEHMPEPIPEPEVIREKSPAAQFTAPTKTLIPDTYARSPSREPSVDGNQQNITQRGQSWSWVGSLSAQLPSVSTVGRILAGIALAAATVYLVAFGGLPSLSRPTQYIPMDESNMLAVSSLTDQMSRIGAQVSSLAKDMRTVKWDVNAVQSEVRSSPAPIMPPSRGTDFGPPTEQKTNFLSIGLGVLVIPGLTSPTVGHKLNPLQWAYVKLWRGSYYRPASPPLAALAPWEDYGDCWCSTPRDGMSQIGIDLGQKIVPEEVAVEHMPKTATLKPENAPREMELWAQYVLVQKGASRHARTLASIHKPIMNALRSAWPTEDPTAYSDDPLLGPSYYRVGKFTYDIHGSHHVQLFQLDAVIDSPELRVDRVVFRATSNWGGNHTCIYRLKLFGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYV7</accession>
    <name>A0A8G1QYV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_521444</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514085.1">
        <property type="nucleotide sequence ID" value="XM_025665202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYV7"/>
    <dbReference type="GeneID" id="37168604"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000003">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="126"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="246" mass="27887" checksum="85F55A1B3EE46A91" modified="2022-01-19" version="1">MPRSKRARVVHESKTVKKSHKEQTRRLYANIRECIEKYDHLFVFGVDNMRNTYLKDVRTEFADSRLFFGKTKVMAVALGHNPENEAAPNLHKLSPYLTGAVGLLFTSRDPQSVTDYFDNFRPLDFARSGTVSTRAFSIPNGQVYSRAGEIPASEDEPLSHTIEPELRKLGVPTRLVKGKVMLELTEGQEGFPICREGEVLDSRQTTLLKMFGVVMAEFHVALKAHWTRESGEVEILEKDEAGMEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ84</accession>
    <name>A0A8G1QZ84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_50419</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514376.1">
        <property type="nucleotide sequence ID" value="XM_025664289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ84"/>
    <dbReference type="GeneID" id="37167691"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000156">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="10"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="77"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="168" mass="18820" checksum="76A4CB4279575C88" modified="2022-01-19" version="1">MFFLKEEVKVITLHPSYFGPNMREYLINRLNEEEEGRCTGDHFVICVMDMVDIGEGRVLPGSGQAEYTIKYRAIIWKPFRGETVDAIVTSVKPTGIFTLAGPLSVFIARKNIPSDIKWEPNTVPPQYTDHADQVIEKGTSLRLKILGVKPDVAAINAIGTIKEDYLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZA5</accession>
    <name>A0A8G1QZA5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_48928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514310.1">
        <property type="nucleotide sequence ID" value="XM_025663591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZA5"/>
    <dbReference type="GeneID" id="37166993"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH56388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="84" mass="9422" checksum="DD72463F1C388A70" modified="2022-01-19" version="1">MAICPGQTRYFFSTPEACHGRPPASIQLEAPRFQTRGRRYSTATTNHLKFLSNGPMCPYCFFAFSIMRMVRSASVAGHSVCWPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0B5</accession>
    <name>A0A8G1R0B5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_451156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513841.1">
        <property type="nucleotide sequence ID" value="XM_025660525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0B5"/>
    <dbReference type="GeneID" id="37163927"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040:SF1">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="6"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="248" mass="27736" checksum="2A00C33128CE77E3" modified="2022-01-19" version="1">MDSVGPTVVDTVAAISQLVDLFNNLPNEPPSLYVDIEGINLSRHGSISIIQIFLLPKNRTFLIDIHTLGQLAFTTASASGTTLKMVLESGHIQKAFFDVRNDSDALYNHFSIHLAGIHDIQLLELATRNFSRRCINGLARCIERDAQLTMSEAREWKLAKDRGRMLFAPERGGSYDAFNQRPLSQDIIRYCAQDVQILPSLWQIYHAKLGGSWKAKVELAVKDRINVCLQVDYTGVGRHMAMAPVGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R195</accession>
    <name>A0A8G1R195_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_514503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515625.1">
        <property type="nucleotide sequence ID" value="XM_025664763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R195"/>
    <dbReference type="GeneID" id="37168165"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF13">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="248" mass="26727" checksum="91145B7592C56C5A" modified="2022-01-19" version="1">MAPSTVVLVPGAWHQPSCMCQLQDELTSRGLNATTVAHPSIGNTSPPLKTMVDDWASLHATIEKLADDGHFVTVVAHSYGGAVTSGAAEGGIVKIVYLAAFVVPKGQTLLGYFGGVAPTYWEFKGDLLYANNPEISDPANLFYNDLPRDVQDYWISQLLPMTAACSQVPNTYEPWKYIPCTYIHAKQDQTLPLEIQEDIVATMGSVTTLTLDSSHSPFLSMPRDVALLVQQSVEEGLEQATGVGISTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1A0</accession>
    <name>A0A8G1R1A0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Actin/actin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_451992</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513012.1">
        <property type="nucleotide sequence ID" value="XM_025660719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1A0"/>
    <dbReference type="GeneID" id="37164121"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH55090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="439" mass="47648" checksum="E3E06C9813CF082E" modified="2022-01-19" version="1">MASQTPAVVMDNGTGYSKLGFAGNDSPSFVFPTAIATKAGAGGAGSSAAGRPPVANKPSFLATGGGAGSHLSAKRGTEDLDFFIGDEALAAANGPGYAINYPIRHGQIENWDHMERFWSNSIFKYLRVEPEDHYFLLTEPPLNPPENRENTAEIMFESFNCAGLYIAVQAVLALAASWTSSKVTDRSLTGTVIDSGDGVTHVIPVAEGYVIGSSIKSIPIAGRDITYFVQSLLRDRGEPDSSLKTAEKVKEEYCYVCPDIVKEFARYDREPDRLLKHTVTSPNGRTVSIDVGYERFLAPEIFFNPEIYSSDFLTPLPNVVDGVIQSSPIDVRRGLYKNIVLSGGSTLYKDFGRRLQRDIRHLVDARIRASEARSGGARSGGLDVAVVTHKRQRHGPWFGGSLLGQTPEFRSYCHTKAEYDEIGPSIVRRFALLGGPGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1N8</accession>
    <name>A0A8G1R1N8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="9">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="9">MTA phosphorylase</shortName>
            <shortName evidence="9">MTAP</shortName>
            <shortName evidence="9">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_470600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="9"/>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Purine and uridine phosphorylases"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="3 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="5 9" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="192"/>
            <end position="509"/>
        </location>
    </feature>
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        <location>
            <begin position="494"/>
            <end position="523"/>
        </location>
    </feature>
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        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="538"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
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        <location>
            <begin position="586"/>
            <end position="587"/>
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        <location>
            <begin position="619"/>
            <end position="620"/>
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        <ligand>
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            <end position="747"/>
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            <name>substrate</name>
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        <location>
            <position position="703"/>
        </location>
    </feature>
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        <location>
            <position position="758"/>
        </location>
    </feature>
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            <dbReference type="EMBL" id="RAH55285.1"/>
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    </evidence>
    <sequence length="829" mass="91389" checksum="19E127D0EE9E609F" modified="2022-01-19" version="1">MPSHSFKRIGIVGAGNMGSMMSFAFTELGLDVSIWDVKRENVDGIKKWYDEGKFSGKGKVEGFYEIDKFTKSLEGQGERKLFIFSITHGDPADSVLDMIQNDLKKGDIILDGGNENYRRTEQRQKRCKELGVSWIGMGVSGGYQSARHGPSLSPGGDPEAIELVLPLLEQYAAKDEKTGKPCVTNVGPAGSGHFVKMVHNGIEGGMLSTTAEAWALLHWGLGLGYQEISDIFEDWNTKGELRKNFLLDIGVQILRTKKTPQGDYQGEGASQNGGYVLDDVLDKVVQDDDDTEGTPYWSVMETANRHVAGPTLATAHYMRIASGNRAERLEVAKKLNIPGPRSIETKDRKDFIEKLRRAVYCSFLASFCQGLELIARASKDEGWNVDLSKCIQIWRGGCIIQSEAIADLLQPLMQPDLTNMKFLDEVARELHKHFDALKEVALAATVADQYIPALSATLEYLKYEGGTMLPTKFMEAQMDLFGAHAYYIPGAPGEDPGPVKKGPHHYEWQSSPQSNSPKEWPPFPPPTTPVRIAVIGGTGLRELPGFTQVASFNISTPWGTPSSPITILHHKCSHNNQTVAIAFLSRHGLHHQIAPHEVPARANIAALRSIGVRTIIAFSAVGSLQEEIKPRDFVVPDQVIDRTKGIRPFTFFEGGVVAHVPFGDPFDEGVAKVVRACGHSLEGEGVVLHDRGTLICMEGPQFSTRAESKLYRSWGGSVINMSCLPEAKLAREAEIAYQMICMSTDYDCWHESTADVTVEMVMGNMKANAVNAKRFVTAVLDELAAEQNSQLVQAKHIEGSVKFGMSTAQPNWSPEARERMNWLFPGYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R251</accession>
    <name>A0A8G1R251_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA-specific adenosine-34 deaminase subunit Tad3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_376627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025656232.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytidine_deaminase-like"/>
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        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="454" mass="49780" checksum="E1E8CC3804D5C242" modified="2022-01-19" version="1">MDVEELLRGIKPLEGQVTAIRTVQETRPREDYADAYVTEVNVKCASKVIKVLDSRFPRDSSQPLSHLRRFAKHNQIPEHLRPILLREGSSPAQTIFVLISPPLPDIESLQDALSPFAPPTPTEGENSSPLTFHTIRIPLQPPLTPVQADAWSKSMWPVVYNPAAPRAMIAPPPHILARARDSIQPKAGRYLALAQRVADEAERSGLGRRVGAVVVDPDLEAEAAPDNNDNGIHWSDAVVAVAGDGRYSRAATDTEAPNPPNHIATTYSPDHEGGPELHALMRAVDLIASKRREDRPGSSATNRPCLTDVERYFLSKSDVDTTAAATSTSTSRIRPRSQGGYLCTDLDVYLTHEPCICCSMGLLLSRFRAVLFPRSGRMVSGGLASEPVVGPVPVEEDEDKNEDGKDEHDDGSVEREYYGLHWRKELNWRALGFEFVEEQGSAEGSAELGVAFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2E4</accession>
    <name>A0A8G1R2E4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_291793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515930.1">
        <property type="nucleotide sequence ID" value="XM_025655273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2E4"/>
    <dbReference type="GeneID" id="37158675"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF80">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034472065" description="PLC-like phosphodiesterase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="40591" checksum="50CD9932B7E1A02A" modified="2022-01-19" version="1">MLGLGVLALLPFAAAKAVRPRSTACNNSPDLCSKSYGEITHLGAHDSPFLRDASTDYSTFGDQYYNTTLQLDAGVRLVTAQVHKSNSQWRLCHSSCDYLDAGLLSTWLSDIKGWLDSNPNDVVTVLLVNSDDATASDLHSQFETANLTNYTYTPTSQTSAPSSWPTLQELINNGTRLMTFVASLDASSNTVAPYLMDEFTFIWENNYDVTSASNFSCEPDRPSSVKNELSTALSSNRLPFMNHFLYQETLDIEYPNVSYISTTNAASGGTGNLGDTATKCKKEYNGRQPTFILVDFFDKGPAIDTVDSLNNVTNATGRKNLTSVSVTSSASTYSNVFKGLVEVVQKAKDGANPSMGEWIWAGGDWGSLLGGGIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2J3</accession>
    <name>A0A8G1R2J3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_448829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516778.1">
        <property type="nucleotide sequence ID" value="XM_025660032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2J3"/>
    <dbReference type="GeneID" id="37163434"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="69" mass="7153" checksum="9D9926BFB3C18C65" modified="2022-01-19" version="1">MSDRTGSTTNNNNNNRSGGSTSGGAQITEAKASIITSPRNINQLSTWGQSARDRRQGGNKGSDSKGPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2U4</accession>
    <name>A0A8G1R2U4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Plasma membrane antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_372049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515414.1">
        <property type="nucleotide sequence ID" value="XM_025656019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2U4"/>
    <dbReference type="GeneID" id="37159421"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF5">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="7">
        <location>
            <begin position="28"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="513"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="530"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH57492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="565" mass="62638" checksum="C812A43F94E43953" modified="2022-01-19" version="1">MLHPFLDVSNFNLVLSVTGLYILLFGFISLKVKQRWYLGEALPAFMVGICFGPAGAKILNVSQWGGDSANETSEIAYGLARLVIGVQLVKVGYELPKKYLRQRMVEMIICLLPLMTISWLATSACVKLVIPHISFLSALIISACVTCTDPVLSQAIAKGPFADNFVRRPLREFISAEAGGNDGFGFPLLLLGVSFLRYAEAPANTLSLEEFDLERGVPDVLGTTGVGRFGGGAGVALKHWAIEGVLYMILLGAAYGAFIGFVSQKLLKKAVKHRWIDHESFTLVPAAIGLLLVGTCGCFGSDETLACFVAGCVLNWNGLYHEEIQARHDSFNSTMETLLNFAAFMFLGATMPWEYFQRPHDTGITLWRLFALGFLILVFRRIPAILVGYRFMPKVCSDWKEALFLGHFGPIGIGAVSYVEYTRRLFPPPGQSDEEINSMTAAMVPVVYWLVLFSIVVHGLSVPALNALYSIFKVPRICDHPVTVVLLSENEPLPNNSTMNPQRHSMVLNNRFSRPSESENDQEQEDKEDTETMLRSREESPDRSIERLSTQSSRSIRTVDMRDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2Z1</accession>
    <name>A0A8G1R2Z1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oxysterol binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_420856</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516139.1">
        <property type="nucleotide sequence ID" value="XM_025657906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2Z1"/>
    <dbReference type="GeneID" id="37161308"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13289">
        <property type="entry name" value="PH_Osh3p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000369">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000013">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15409">
        <property type="entry name" value="PH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="200"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="156"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="349"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="518"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH58217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="970" mass="106332" checksum="C9012CF3A13998E0" modified="2022-01-19" version="1">MAAMEELEIHSKSYFVRWVSVKPAHTISWSIQPHKKSINFGIFKHPGHSAVLGSNTNLPATDSPNADSNENLPATAGAAASRPNASVIDKLTGIGLKQIQWIGKCEAERIFRGTYDVPANEGGNYALVFDNTFSKQLSKTVTLALLTYPTALPPQSVPVPHASSHPIRSDTAESGKSLAARRRGNSVAQPPPLASDPDSLNTYTGLLQKRRRKRHQGWARRFFSLDYTSSTLSYYHDRNSAALRGSIPLSLAAVACNEKSREISIDSGTEVWHLRANNDQEFAAWKRALERASAPSSKTPATATDETALPSEPLLRVPSQRVAPNPVEEREWEQVEGLVSKVSGSRDAVRRLAKDTDPKYLGGNVAERPRGRSPSPHRTPTDLNGDETGDAKRPFWKRKNSTATQPGVKRTTTMASMSSQLAVPGAFDTASLAGDRKPSSIASPPDPMEEVHEHLMAVLRDLDQVVSEFSTLISESKQRRHPPGATVQARRSFESDVSQEFFDADDGKALLTIKGDSDDEAAADNASDHTVWDSKPKVEEEPMVNDAPSDSEDEADEAPAGHDQYSPLFPGRPKALTPLPLSPVKRRANITAPTVMPPSLIGFLRKNVGKDLSQISMPVSSNEPLSLLQRAAEVMEYSTLLDRAASASDPVERLMYVTAFALSPISSNRIRERAIRKPFNPMLGETYELVREDLGFRFIAEKVSHRPVQLAYQADSKDWSLTQSPMPTQKFWGKSAEIITEGKMRLTLHTTGEHFSWAQATSFLRNIIAGEKYVEPVGEMVVVNETTGHRSLSTFKAGGMFSGRSEEVSTKSTDPSGRDLPLGLTGTWTSSLDLTKNGNPSGTIWSAGPLVPNAPKHYGLTAFAATLNEVTPIEDGKLPVTDSRLRPDQRALEDGDVDQAEAVKVQLEEGQRARRREMEAAGESWTPRWFTPVDEAPGDETVWRLKSGKEGYWEERSKGAWTGVVPVFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R331</accession>
    <name>A0A8G1R331_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_276364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516461.1">
        <property type="nucleotide sequence ID" value="XM_025655148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R331"/>
    <dbReference type="GeneID" id="37158550"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="194" mass="21404" checksum="CDE42314FA7EA395" modified="2022-01-19" version="1">MRLLGVSWRPSDSRLAVDPRSNNPIGRIRWKGSRQVEKSPTTISNCPAGKTHACQLGDRCLFSCDPLALALLRLQESYSSPKCPSPRDRRAPPMADPYANAWMPFYKMSAPETRVQRQSSTACLSHATILRPTRRSFESRHHLAGRLPGLCVLWIQPGSDGGSPHAGVVCGDVSPDEHFDHHWGPAALQLHHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R357</accession>
    <name>A0A8G1R357_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_513320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515718.1">
        <property type="nucleotide sequence ID" value="XM_025664703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R357"/>
    <dbReference type="GeneID" id="37168105"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="216" mass="24232" checksum="1EF70D6ACBBD54A3" modified="2022-01-19" version="1">MAAPPASNFFYHTRPGKQNSRSPPRRFRPNGPKQSPPSIRTNNTPSSNAPQHQRQPNLHYKSNSGISKPAPRKPHRDVDGDIPMTDVFVKPQPQKRQPPPTKAQPNTGRKANNINNRKSIDGDTIMLDAFPMSQNLRRQLNNTNTPPQYRRGTPIKTAPQRPFSKDLDGDTPMFDILDMAPTPVNLPVLQPIQLPCYPITNLPVDFDGDSMMLEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R420</accession>
    <name>A0A8G1R420_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_448040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517001.1">
        <property type="nucleotide sequence ID" value="XM_025659847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R420"/>
    <dbReference type="GeneID" id="37163249"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="12"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="858" mass="96528" checksum="9695164A5395A3CD" modified="2022-01-19" version="1">MLPGFLQSSYARYKADTNTFATWLLETANKCGYRPTLSATIPTTNKSKREGKTDGSNEHPIQYTATTKDLQKFAEVIAGSSLIVPKSVITIAKRAIKLRKTVTSWFLGRGDIANNKRHAHFITALEQICDTLEWKTAQPSKTDAKQPHSMPEVQDDDADADKFLNKFAVLTVEEPEDIPDTQSAPAASKKVVKVTVVEEENEAADSYLGHLLFKTLCLLRDLNNIRKFISITWSEYRDKKIDLMNAAVVTDSALQLARDMVKEVEADWLSTRTPARNDIQTLVYNLAVMSRGISAAPSTEVGLPYNKNMADVADWCYVPTKVLLDAFANVLHDNHQPVFKKGYFGTYNPKANRERMSVGQKFNEDKIILLSILPEFCMFDTFKFRTPTSDAITQGLVEFSKNRKVTLWLCFASQIFLDIHHIMRHSTLGAFGDLRMSGLRIQKVIDDYLKLSKTHPKPKFWAKEGDEEIQGISSTVDSWIIQDAFLNLRVLSGLDKTGSPPEKHALLSQHSILCGLILFHLNIRMQRVGQQLVTQWYDVQQLAFLHNLVINYATHKDVRWPDMDAFIKIHGESHIFIGSRPQNAGESLNRLELATGISSAANFARDSRSKPFHKPDGKNPRLLKPTTAVANLFSPKYVEGLAEDAGIVNIDRILDELSQESKLESSSCKEPLRANAELSITQKWSNNRNIDTLHLLAFLKTKLYEEEPVILYNYFGMHKRSIELLRLIREKEHHKFVQYFTAGYMPDESFIPNIVLLIHHVARGSAQNARSMGLGSGDVELVSRIVMSSGDVMREYLKKNGDVACKELRVFCKNKKPIQDEVADDAGESDGLVTSWLHLEDVLGPKGVASLMTGIPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5G9</accession>
    <name>A0A8G1R5G9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_253669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517845.1">
        <property type="nucleotide sequence ID" value="XM_025654956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5G9"/>
    <dbReference type="GeneID" id="37158358"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="76" mass="8548" checksum="85015D198DEC02DF" modified="2022-01-19" version="1">MAKASLLRSHDAANGTNHGLFIFSLIFLFRRHLKAWSCQSRVDPPGFVIVSCQHAFLADNVIDNCFSESAWLQNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5Y5</accession>
    <name>A0A8G1R5Y5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Multidrug resistance protein Fnx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_448820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516766.1">
        <property type="nucleotide sequence ID" value="XM_025660029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5Y5"/>
    <dbReference type="GeneID" id="37163431"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH58844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="503" mass="54188" checksum="5B0E0F5E1CB5F033" modified="2022-01-19" version="1">MPTIVHDLDSSSAYVWIANAYFLTSTAFQPLYGQSANIFGRRSLIILSVVLFAIGSAVSGSARSTNVLIVGRTVQGVGGGGINVLVDIIVSDLVPLRERPKYMGIIFSVFAVALSLGPVIGGIMTQRVTWRWIFYMNLPISGAALMLLVLFLRTEYKKDSIRDMLKRVDFAGNALLVASVLAVLLALTWGGTEHPWSSWRTILPLVLGILGLAGFMVFQASGKGVEEPTMPIRLFTNRTSLATFGLTFLHAILTYWMTYFLPVYFQAVLEASPTASGVDFLPSAVAAIPFAIFAGAGLSILGRYRPFQFIGVILLTVSFGLLTRLNAMTSTGYWVGVQILAAAGSGVLLTTTLPAIQAPLPEADVAVATATWAFLRSFGGVWGVAIPSAVFNSRVNALVDRVKSSVLREELGNGGAYALASKTFMQSLDSTPDVKAQVLGVYVDSLRLVWQVGIAFGLLAFVVAFIVKEVPMREQLETKFGLTGREDDDRNSEAPIESAEKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6D1</accession>
    <name>A0A8G1R6D1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Casein kinase II beta 2 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_446079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518848.1">
        <property type="nucleotide sequence ID" value="XM_025659418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6D1"/>
    <dbReference type="GeneID" id="37162820"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038816">
        <property type="entry name" value="Stationary_phase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42342">
        <property type="entry name" value="STATIONARY PHASE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42342:SF1">
        <property type="entry name" value="STATIONARY PHASE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH60926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="460" mass="50183" checksum="728DEF430B2D97CF" modified="2022-01-19" version="1">MPPSNGHLLLPKFWRAARSAYEKAYKTIKSRFPEQFQQSSLRLQPEYVRVVNRHPINRAAAIRQARGRHYYSTRAASSFVSYIRSGLQGERTAYKTSRVAANVSRLTKNAPFASTLRPNLTGGTLGRTAGGYAIGAGRIGGARYFSHGAAAPAQVINNVSVGVRAFFLSGQKARFDGVDPITGNKRFKTVSKLQDEAERKMAAIPRTAPGSFVDFQISPTITAFGLQKNLVATGAGDAQTINSDGLLDFPSADFARALKDLAAVLNDLKRLSTLGDLPILLHDNSTIRVRFPGCDASTVERLCDEAGIQRGKIVQDEDFDIRTGADLALLFPFAPSVPASPDVNDYFYRSGTIKSQAPEEVDWHAMMSPEDVSEASPEPYKQPLNQLSFEDVTMFGENPWMSSPSGYSSINVSELGDRAFFAEVASIGLPESASEYEGSDGIRKFIAECDLASRHYGRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6R5</accession>
    <name>A0A8G1R6R5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_188357</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519043.1">
        <property type="nucleotide sequence ID" value="XM_025654410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6R5"/>
    <dbReference type="GeneID" id="37157812"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000985">
        <property type="entry name" value="Serine/threonine-protein kinase MARK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000567">
        <property type="entry name" value="Serine/threonine-protein kinase MARK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF76">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="323"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="268"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="492"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH61121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="646" mass="71344" checksum="A349074F04E6EDC8" modified="2022-01-19" version="1">MAQTGRNNGLVGLKLETSFHHSPRPRWRGDDGGRRASDQGDGIEGDRTNIFHDYHAPRCGTDEDNSALSGLHSATPPISVPRHDDYPKQDVTFPHKPEDVQASSPLDSFLQERRPSISFDAALDSGRRRPLEDPSSPRGDVRSRTQRFQAKSSSLRNSLPLEDDADHNGRQVGLSSSLRRQQERRAIPTGIARDSFPEENGAIPSDYEHPTSLTSLSTASPITEELRTPPEGSRGMLSSPICVASPMQTFASLDDRSSWSGSVMTPFGSKARGLRVSTRQRSRRSTASSGKSPASMFLSMWSAGGDEPAPQPDDEGQMVGTEYVLGKQIGFGGFSTVKEAYKVEESGKTKRLAVKIVKKQVSGRSEKENDEVQAEFDHEVRVWRYLSHPNVLTLDAVYETDYATFCFTKLAIGGTLFDLVRQNRRGLDMTLAKKYAYQLACALRYLHEDARVVHRDIKLENCLLDPTESPDGTKTSTLVLCDFGMAEWMNSDNEDASPDPYDNAADRPPPKTIGPAGSSTSVAGSLEYASPELLSSTNGVIDPSVDMWAFGVIVFTIVVGSRPFQDAFAPRIQSNILSGNWNKHAVVGEEADPQLRQDREDALELIMGCLNMNVDKRWSIRDVLCSRWLREFTDNAESPTESAWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6R6</accession>
    <name>A0A8G1R6R6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NCT transcriptional regulatory complex subunit A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Negative cofactor 2 AB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_486004</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms the NCT transcriptional regulatory complex with nctB and mot1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NC2 alpha/DRAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517454.1">
        <property type="nucleotide sequence ID" value="XM_025663362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6R6"/>
    <dbReference type="GeneID" id="37166764"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000036">
        <property type="entry name" value="CBF/NF-Y family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="10">
        <location>
            <begin position="176"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00075891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH59532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="290" mass="32627" checksum="4C0A5A20BFC32A18" modified="2022-01-19" version="1">MTDQDQSYRPRSPDFSTFQSVPLSPTFNNHNLNHNTHYQLPHHSPVYQFGNPFVHRASYDASPFFTPQYQPPPLPQQPSLPHHPVPQTRVPQQSSSYFPPDPDMARRSSRIAQAAEVAPHPPVSKYVDPVDEEEEFIPSPPPQPQPEPQAEPVAVIEEEEPPKPAPVPVNVEVKTKFPVARIKRIMQADEDVGKVAQVTPIAVSKALELFMISLVTKAAREAKDRNSKRVTASHLKQAVVKDEVLDFLADIIAKVPDQPASRKHDDDNSDQNEQQPKRKRGGRRPKEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6V5</accession>
    <name>A0A8G1R6V5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_269126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517276.1">
        <property type="nucleotide sequence ID" value="XM_025655074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6V5"/>
    <dbReference type="GeneID" id="37158476"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034261148" evidence="1">
        <location>
            <begin position="20"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="210" mass="21676" checksum="3E323EF4E3BB7E94" modified="2022-01-19" version="1">MRTSYLLAAALTLLGGAYADDDSTTVVGYFMPYWSVDLPEYGGWTSTGASVAGINAVKTTYKMSCLKDAPKTDCDMKDAYTIIQGPETVSVSQVYTASTSDKTTSFDVTVTLSYECSLKSRTESASCTMSAGFSGSDDGATYASSTSTKSTYENPTSRFYSLVVTGGVKSFTEPAATKTPDAAAGVGAPVAAMITAAPVAAAAMVAAAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6Z7</accession>
    <name>A0A8G1R6Z7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cell cycle regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_366433</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518640.1">
        <property type="nucleotide sequence ID" value="XM_025655778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6Z7"/>
    <dbReference type="GeneID" id="37159180"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000025">
        <property type="entry name" value="FIZZY-related 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="10">
        <location>
            <begin position="289"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="416"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="458"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="546"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="190"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH60718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="602" mass="66885" checksum="7C89D8BEEE4BED69" modified="2022-01-19" version="1">MGDPKKSDRPTTRNAAAGAPAVKSPDRTGPNALTIASPPGSRTPPSMPSKKTLFYPEPQARSQNSRATSGPIDADALAKALKDFEDAGRPRERTPGTSPSRKRQRVYGDRFIPNREGQDLQATFSLLHEDGCPSTPSKSKKRAPHSELHFQKTEEANRMYSRVLRSELFGNTVPQADLDSLSPDPLLGMGNGINDKTRSHTPPSHVVSNLPPASITPSTPHKNLFNYASPRAGSAHPTPSKTPRSQHGPNLNVRSELYSLSPIRLDSQRILETPRKQPRYVNKVPYKVLDAPDLQDDFYLNLVDWGSSNVLGVGLGNSVYMWNSQTGRVTKLCELRDDTVTSVSWIQRGTHLSIGTGKGLVQIWDAERCRRLRTMIGHTNRVGALAWNDHILTSGSRDRLIFHRDVRSPDQYLRRLSGHKQEVCGLRWNTEDGQLASGGNDNKLLVWDKLNETPLYRFSDHTAAVKAIAWSPHQHHLLASGGGTADRTIKFWNTSTGSLIKEVDTGSQVCNLAWSKNSDEIISTHGYSQNQIVIWKYPRMEQIVSLTGHTFRVLYLAMSPDGQTVVTGAGDETLRFWKIFNKRPGREHGREGSKLAEWGTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7I8</accession>
    <name>A0A8G1R7I8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7603 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_184505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518925.1">
        <property type="nucleotide sequence ID" value="XM_025654374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7I8"/>
    <dbReference type="GeneID" id="37157776"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056023">
        <property type="entry name" value="DUF7603"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24554">
        <property type="entry name" value="DUF7603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7603" evidence="4">
        <location>
            <begin position="788"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="622"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="920"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="467"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="873"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="962"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="631"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH61003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1030" mass="113648" checksum="58088CD6BBDB72A7" modified="2022-01-19" version="1">MAPGWTSPPASGALPSSPNHNHLHSSSQTHHQLSPSPVSDDPGAWPSPPPPHPRPPSSASSSTSAAAAAAGPVTSPTSHLPPSTTSLASPPPSATLVRRKPLPQDAVILSRQSRPPSSPLLPFSPPGDSPADPLSLPVSSSPLAAGHHNLAYSPASTYSFSGSVYEVDGQEEDDDSLHSVPRNLDRSPRGGPSASHLRIDTSAAYVDDDEESSNANTHNPRYSSQFSNGTSLHSRLVSEPFVPILKSPAFLPKRPTTMALHLPSRRPPPLHIDSPSRSSSGDSKQPKTPANKISSFFGWRATTSSPGAESSSTEISETGRSPVPSPMPASLHSASFSITPSTTVPFDPSKPQVPLPQRNPSLSSGSILDSRATTLVTELENELREISAELAGSIRREMELEDLVERLQSDMPLDTPNRRTSDYFSDSGSSSIRYAFESGGRVEDIEKYKRTAEQERAQIKVDLGQKLQEERSRRAASEAHVQILESQVQQLRRERVDLSDLSSRTRELEAALDDTRRKLAEERQIKDNFEDLLTAMRVELEQLRNERDHMRDTVIPQLQQGSQSASPPSDPSEVQRLMEEIEALKIENASLAQLQGSRFASIAEEDGMPTARNVGLGLSRSNSLARVRTKPSPGLSRSSSLSRSNSVSAKERNESPRENLADRIEDVEAQRDALHQSLRRLLDRQAHDAREYEKRLQLMEMELARAQQVGSPRKLGYEREVRNLREEVNDLRQRAEEALEQKWQCEKGLAGLKMDLDRAEQETTSLRVILQEHDITVPEDLECDRDGFAEVLATSSSLESAYRQLQADREIAEASAAQSPLAEQNSLVESVNRTDVLAQHVQQQLASNNALRSRLAEAIGKGEKEQQLSAARINEMQARLKEMEDILLMAQQYSEDEMARHEEEVRALEENHNAQLKRMKNGARSPAALSPMPPTTPFGSRSPRLDLTTSGRGIALDQAIQSETLERRVKELEKLLRDADSEMEEVVSRMNRAQIEVAELQSDRDDALRQTRKLQAEIMAQRETFRTLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7P5</accession>
    <name>A0A8G1R7P5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Quinic acid utilization activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_187617</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519015.1">
        <property type="nucleotide sequence ID" value="XM_025654396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7P5"/>
    <dbReference type="GeneID" id="37157798"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000005">
        <property type="entry name" value="Quinic acid utilization activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF2">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="676"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="758"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="766"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH61093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="933" mass="101633" checksum="90F948BC9B3205FB" modified="2022-01-19" version="1">MNNDTRQASGPGSKSKRRLTDVEENSKQSPAADDFASNPKRQRVSRACDSCRSKKDKCDGVQPVCSTCASLSRPCTYKANPKKRGLPTGYIRTLELLWGLVFNKIQGSEEVVRALLKAANIPSHLATMGKEAEGSDTLLSSWKNSIVLREIERLLTFLEQPEEDQAGRLPGESDSPQDAEGSSVLSAEALEWNLPDVLGEGREGSLAVVSPIKTPSAVSTAKASGVRITRDSATQTATTNDLGEDVSSLSLGRLAQRPPDQASLPIPIPQLPSNAWPLLDIYFSYTQCWFPILEKHDILRTAFRHNEDDAQISATSPGSGDYAALWAVLTLASIQEASISTTRQLNDFAGDRPDPAQLYATARRLIPEENGNHELGHVQALLILSLVKLGQQDWSAAWLLVGQAVRIAQSLGLNQSTGQSKSAEEGKSAPRSKHVFLGCFILETLVAMQTGQVPSLRKAELIKIGPINEDGLEEWHPWEDQTGLRPVEPSRASFHRGPLHALSTFNRLTSLMCILNDLCCLKQTTTGPIAHLEALERQLQLWVSALPKSYRVDLQTTPIKVASPHIFGLEMMYESVATNLSLQFALQRSDRNMSEMPLKKRATESSKRLLQLLQTYMENYSLSATCPTFGLVLTSGLSPAGERAAPLPFELDPGLKSKLQSFAAHLATVWHIKDRPDTTLPEKTPDLPASITPAPARPRSLSNRDTGQLHAFAQAPLGAGEPARRVSMLEDNRTNIATPDAFFSNGWMRTPTVDDNVALSIPTPAPSLNINQSGETAHPSSQLKESVPPNHLSHHPRSSISSTKPINGTGTPLMPDLTSPFHTTAPQYPPPYGDTSLNLGSFVDIDGYGPPRRPRIAPDLDALFDELASLDGTEKTDNQPEFMQNLGFVPEAGVPELYSYSSQVEPFLLAQTQQQVPCEVGGVRRGSQAEGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8I5</accession>
    <name>A0A8G1R8I5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_411882</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519420.1">
        <property type="nucleotide sequence ID" value="XM_025657547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8I5"/>
    <dbReference type="GeneID" id="37160949"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000003">
        <property type="entry name" value="Dna repair rad14 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="12">
        <location>
            <begin position="212"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="312"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH61498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="367" mass="42294" checksum="786ECEEB9085C029" modified="2022-01-19" version="1">MVTEEQSAPPPEVGMGTPGGPKRTPLTPEQLRRIESNRQKAIAIREQREAEQARADPSSTKGVKRTYSSMTASDPPATLRDAASTDNRPLDGIKPARNFTKFVEYDFSKITDTKGGFLTEEDDRFNKALHVRDEKAEQKPAHMTQKEWERQQLLKNLHRDRAGIFEPGLSVLDERTQQKTCRECGSLEIDWKWEEAFRCCVCHACKDKFPDKYSLLTKTEAREDYLLTNPELQDEELLPHLERPNPHKSTWNNMMLYLRYQVEEYAFSAKKWGSPEALDAEFERRENEKKRRREVKFKSKLEDLKKRTRVDAYRRSRQGAAGGNFGDDLGSGGRHVHQWGRSVEDPKTGIGVKKCVDCGMEVEELEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8M0</accession>
    <name>A0A8G1R8M0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial F1F0-ATP synthase g subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_446787</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518161.1">
        <property type="nucleotide sequence ID" value="XM_025659577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8M0"/>
    <dbReference type="GeneID" id="37162979"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12386">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH60239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="198" mass="20849" checksum="10462932F12BC206" modified="2022-01-19" version="1">MPATASRAVLRQSQFLTRRSAVRYASSTSEAASKAGETASSAASKASEGLSRVSSTAGPAISNAAQGLGSALRKVGGRTGKVIAFVDSMIPPTVYYSKVGIELAKLVFRGQNMTPPNMATFQAYFQPLTNAFRNPAAFKNSSFAPSNIISRVRTANKKEIALAGVTAAEIVGFFTVGEIIGRMNIVGYKGQPEHHGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R903</accession>
    <name>A0A8G1R903_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_456887</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519289.1">
        <property type="nucleotide sequence ID" value="XM_025661480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R903"/>
    <dbReference type="GeneID" id="37164882"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000266">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="75"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="528"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH61367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="602" mass="66166" checksum="E46D4C5F4DE127B6" modified="2022-01-19" version="1">MATEKGDSGPSVIEAPESRTIPFWRLLTDQGVVTQEIIDYHYPGSGTDEDPYAVTWLPNDPRNPMQFSAAKKWSFTMVMALATLAVALVSSGYTGGVLEIEEQFGIGTEVATLGVSLFVLGFAVGPLLWAPLSEMFGRQIIFFFTYMALTAFSAGSAGSQNTWTMIILRFFAGSFGSSPMTNAGGVIADMFAAKDRGIATSLFAAAPFLGPVLGPIIGGFLGMNAGWRWVMGFLGAFSGFVWIIGSLTVPETYAPVLLRRRAERLSKLTGKVYRSKLDIDQGKTTIKQAFKTALSRPWILLFREPIVFLLSLYIAIVYGTLYMLFDAYPIVFQEYRGWNQGVGSLPFLGIMVGMLAAVAYNIWDNKRYIRAQEAHGGFAPPEARLPPCMVASIAVPIGLFWFAWTDAPSVHWMASIAAGAPFGFGLVLVFLSNLSYLIDTYTIFAASVLAANSVMRSIFGAVFPLFTTYMYENLGIHWATCVPAFLALACVPFPFLFYKYGPAIRTRCKYAAESDAFMRKMLEQLAKKPDPEEEVIAEEKFDRTEAPAPGVEADDSDSSTEAHMPAAHRTQSKASVRTAKQSLYEGNPYDIDRVHTRESFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9M4</accession>
    <name>A0A8G1R9M4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen debranching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.25</ecNumber>
            <ecNumber evidence="6">3.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycogen debrancher</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO85DRAFT_445531</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.</text>
            <dbReference type="EC" id="3.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycogen debranching enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="5"/>
    <dbReference type="EC" id="3.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520031.1">
        <property type="nucleotide sequence ID" value="XM_025659285.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37162687"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11327">
        <property type="entry name" value="AmyAc_Glg_debranch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000039">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000242">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000333">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative (AFU_orthologue AFUA_1G02140)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029436">
        <property type="entry name" value="AGL_euk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006421">
        <property type="entry name" value="Glycogen_debranch_met"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01531">
        <property type="entry name" value="glyc_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14699">
        <property type="entry name" value="hGDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Eukaryotic glycogen debranching enzyme N-terminal" evidence="18">
        <location>
            <begin position="37"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="19">
        <location>
            <begin position="136"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="20">
        <location>
            <begin position="740"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="17">
        <location>
            <begin position="1069"/>
            <end position="1527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RAH62109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1539" mass="173020" checksum="37ECD642341700B0" modified="2022-01-19" version="1">MSSPQQVYLLPLKDDGSPDVPGGYLYLPSPTDPPYLLRFVIEGSSSICREGALWVNIPEKGESFNRSAFRSFSLSPDFNKNIQIDVPITSAGSFAFYVTFSPLPEFSVLSTPTPEPTRTPTHYIDVSPKLTLRGQDLPLNALSIYSVISKFMGQYPKDWEKHLNGISQRNYNMVHFTPLMKRGASNSPYSIFDQLQFDDAVFPNGEGDVARLVSKMEDEYGLLSLTDVVWNHTAHNSKWLEEHPEAGYSVETAPWLAAALELDTALLKFGQELSTLGLPTEFPTVDELMKVMNAMRDKVISGIRLWEFYAIDVKADTQRILDQWKTSKDLDLTDKKWAQLNLSDYKNWTLKQQATFIREHAIPTSKQVLGRFSRAVDLQFGAAILTALFGPHDPPTSDTNAVEESLSKILDEVNLPFYEEYDGDVSEIMNQVFNRIKYLRIDDHGPKLGAVTAQSPLIETYFTRLPLNDVTKKHKKEALALVNNGWIWNADALRDNAGPDSRAYLRREVIVWGDCVKLRYGSCRDDNPFLWDFMTDYTRLMAKYFSGFRIDNCHSTPLVVAEYLLDEARKVRPNLTVFAELFTGSEEADYIFVKRLGINALIREAMQAWSTGELSRLVHRHGGRPIGSFDLDLPSSGSSHAIASSGLDSSKEKVAHIRPTPVQALFMDCTHDNEMPAQKRTAKDTLPNGALVAMCASAIGSVIGYDEVYPRLVDLVHEHRLYFSEFSEAPETGLNSLQGGIGGIKKLLNDLHTRMGVEGYDETHIHHDGEYITVHRVHPRTRKGVFLIAHTAFPGQDGKSVLAPTHLVGTHVKHIGTWLLEVDASQTTKERIQADKSYLRGLPSQVKTFEGTKIEESGKDTIISVLDSFVAGSIALFETSMPSVEHASGLDNYITEGVDHAFSDLSLVDLNFALYRCEAEERDSSKGQDGVYDIPGHGPLVYAGLQGWWSVLENIIKYNELGHPLCDHLRNGQWALDYIVARLEKLGHTDEHTALGRPAAWLQEKFQAVRQLPSFLLPRYFAIIVQVAYNAAWKRGLQLLGPHIQKGQEFIHQLGMVSVQQTGYVNSASLWPTKKVPSLAAGLPHFAVDWARCWGRDVFISLRGLLLCTSRFEDAKEHITAFASVLKHGMIPNLLSSGKLPRYNSRDSVWFFLQSIQDYTKMAPDGLRLLDHKVPRRFLPYDDVWFPYDDPRAYSQNSTISEIIQEVFQRHAQGLSFREYNAGPDLDMQMTQAGFQIDVKVDWETGLIFGGSQYNCGTWQDKMGESAKAGNKGVPGTPRDGAAIEITGLVYSALTWVAELHEQGLYKHDGVDIGDGESISFKEWASRIRANFERCYYVPLQPKDDGQYDIDANIINRRGIYKDLYRSGKPYEDYQLRSNFPIAMTVAPDLFTSSKALAALALADEVLVGPVGMATLDPSDLNYRPNYNNSEDSTDFATAKGRNYHQGPEWVWQRGYFLRAFLHFDLARRTTPAERTETYQQITRRLEGCKRALRESPWKGLTELTNKNGAHCADSSPTQAWSAGCLLDLYYDASRHSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAG5</accession>
    <name>A0A8G1RAG5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_484913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519091.1">
        <property type="nucleotide sequence ID" value="XM_025663274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAG5"/>
    <dbReference type="GeneID" id="37166676"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00385">
        <property type="entry name" value="Isoprenoid_Biosyn_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH61169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="729" mass="82696" checksum="738C56365932EA5B" modified="2022-01-19" version="1">MNDHRQTPGSVEPGAGSNLSPFIHSKPAPMDDTLRSRLLTRFQPRISNYNSVSHDACIECHIDLFGRDGVGKMIGGMNAHDGDFIALCAPEALPERIGFCSYFNEYGFLDDDMSVDAIQPARPVLTDPVLTRALGAEKAEDITTVNGNSQRKQQIMAKIWAIQKELDPAYLSRSQTALRQWFETAQQIRDKCFTDIDDYLATRAVDCAANWVVHFMAWSSGLVLTPEEYDKVGPVTYLAYAVLAITNDFWSWEIEKRETRKSEGSAPLVNAVQLVMEIHNTDEESAKEIVCNLIQEHEERYCRLRDEYLKRPDITLAIKKWFRIVELSIAGNAMWSIRVLRYHQDVQNPYEGTFDFPSVFSSLKITQYAPDVLSEREDISDVKQKSPVLAPASKLDDTILWKPYEYLNSTPTKGLHNQLVDALQEWYQLPQPSLAIVSGIATLLHEASHMLNDVQHVNPLRRGKPAVHRIFGVGQTINSAWSQINYAQRICLQLSASAYLIFSDQLAHLFAGQAHDLHWARHKTIPTEEEYFRMVDGKIQENGSLLVLISRLMQNEATQNSTLDLTHFMNLIGRAYQLGDDYQCLASADYTTQRGLCRCLEQGVFCYPLLRALQNSEDPTVLVEWLQHHGGSTNNNSPEITFISGLIERNRGLEATRGVLHELSVEIMRQLEMIESKTRVKNWLLGSILDKLQNDLSSHKPESKKEDTLEKVLRVWGGYRNEAGRDVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAN5</accession>
    <name>A0A8G1RAN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral peroxisomal membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_413562</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520310.1">
        <property type="nucleotide sequence ID" value="XM_025657611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAN5"/>
    <dbReference type="GeneID" id="37161013"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052646">
        <property type="entry name" value="Peroxisomal_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="7">
        <location>
            <begin position="312"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="551"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH62388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="612" mass="67710" checksum="918AAC75846D56FC" modified="2022-01-19" version="1">MAALEDIPWIDSMAPSSSTQDHADSQPPTVAAFSPTTISGSSVTSRQRSSIIVHRKSPLLVATPPQITRALAYSHPFILPLNKLVGLLTWTTGDGWQSFLLVAVFWTLVLYGDVIITWTGPLLVVIGLILGMYWRRYSPLSSRAHLSEKQGHQRAASETFPHRHETLDEIVETLRTFTTRCNILLEPLVEFTDFLSTQRTATSATTRPALTTLFIRILFVTPIWIALTLPPLYLITTRRVIMTLGTIILTYHSRPARVSRVILWRSLTIRRICSIITGLSFSSTVDKAHSLLMQSQGHAMSIATRRRGDSSGVRFTFVIYENQRRWLGIGWTYSLFPSERAAWTDEHLNHVPSKEDFELPGVANGNAQWRWVEGSDWRIEGADESGKSDAKADGGGWVYYDNKWNDGRRGQDGWDRYTRRRKWCRDAELVEIPSAGESTSVETKSGIAQSLEQEKAANAHEKEISSTVDADAESLAPSTSSKSRKRRWFGSTKSVSDKASSISSAPPTSTNNSSVDLGKLKSATPTGSYTPTGKSTATATRPISIPHARKSSNYSGGSASHSSSFGRDGSIREKEMSLAQDRLDRWGTRATGGTERAEREMGLGDEVNMGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB09</accession>
    <name>A0A8G1RB09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_417640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CWC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517887.1">
        <property type="nucleotide sequence ID" value="XM_025657780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB09"/>
    <dbReference type="GeneID" id="37161182"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000045">
        <property type="entry name" value="RING finger protein 113A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="256"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH59965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="339" mass="37299" checksum="06D18B5AFE2FCA81" modified="2022-01-19" version="1">MAETANETAAAAAADPQPPVVTFKKRGAKASQNIRKRPAPPPVSQDDDSSDFSSSEDESGHRIKRRKNKGAGIVSASSATTKPVDREPATTATGDGKVQLADTNDATKHVDWFDEDSKDARSSKTQATSSEPQMPDGTYKGLANQTSFIKKNPNAPNRSFGPIKAATNIRTITVTDYSPDVCKDYKQTGFCGFGDNCKFLHDRSDYKQGWELDREWETVTKGKQLKGTVVASADRTTTENKDDDEEAMLEDIPFACFICKGPYREPIVTKCGHYFCEQCALQRYRKDPSCAACGSATNGLFSTAKRLKKLLERKRELAAKRRQEAIEAGEEVSDEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB75</accession>
    <name>A0A8G1RB75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Allergen Asp F4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_362319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520429.1">
        <property type="nucleotide sequence ID" value="XM_025655622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB75"/>
    <dbReference type="GeneID" id="37159024"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038903">
        <property type="entry name" value="Allergen_Asp_f_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25312">
        <property type="entry name" value="Allergen_Asp_f_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034318219" evidence="2">
        <location>
            <begin position="20"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="279" mass="28803" checksum="8D7FEE7B253B3A6A" modified="2022-01-19" version="1">MYFTTPFLLLAAALPSALSQPTPTKVQGHSRRQIDISASASVSISAPSSSSSSSSTSSASSSDWTSTPSDGDYSTSGFGSETSAYGSGNTYMGNVGNPWGSNMVEVSASEASNYKYVMQVTGQNTEDWTVVFWNKYGPDGKMDGWYGYSALSFTLSPGDTKYVAFDEDTQGGFGAAQGSSLPTGSSGGYACTWGEFDFGSTANSDWSGFDVSAIQAQDNDMSVQGMQICDALGSTCSSITADAAEVDNAYTSAETDEGGIGGNLSAGPVRLAVVIDYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBV4</accession>
    <name>A0A8G1RBV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO85DRAFT_392174</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="3"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518367.1">
        <property type="nucleotide sequence ID" value="XM_025656836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBV4"/>
    <dbReference type="GeneID" id="37160238"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000016">
        <property type="entry name" value="Protein arginine methyltransferase RmtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000034">
        <property type="entry name" value="Protein arginine N-methyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049482">
        <property type="entry name" value="ANM3-like_C2H2_Zf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF116">
        <property type="entry name" value="PROTEIN METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21137">
        <property type="entry name" value="ANM3_C2H2_Zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15 21" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 15 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase 3-like C2H2 zinc finger" evidence="19">
        <location>
            <begin position="76"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="18">
        <location>
            <begin position="249"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="20">
        <location>
            <begin position="352"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RAH60445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="546" mass="61445" checksum="574FFF04F103ACCD" modified="2022-01-19" version="1">MSASALPSERLPRDDDARSVSSDSSDVSNEEGWEDVEPDDDTQPVVGLFSEKVYPDVRAMLKETKDKYNFDLRRIQKELDLDFLGTIKLVNYVRTQVKEGNMSPDVSSADKFEDDAYLKPVLEDDALLYSLDDIEDETPETTGGSDAERRVIELQEDLERLQTQFSEYREAVQKSMEEQLTKEDEKLGSTLSDASAQKAANRVEEIDADYFTSYAYNGIHESMLKDTIRTDSYRDFVYENKHVFKDKVVLDVGCGTGILSMFCAKAGAKKVISVDNSNIIDRAKEIIYENGFGDVITCIRGKIEEVTLPVQQVDIIISEWMGYGLLFEAMFDSVIYARDRYLAPGGLMVPSHATLRVAPFADPDFIANHISFWKSVYGFNMSSMLTGIYDEALVRVVEPSSIPGQSAVFLPLPLHTITVEELSFLKEFQVTLTEDIDALDGFAIWFDIFFMPSRDSPIADDAVPSEMQKKGIVAFTTGPYGKETHWQQSILLIDHEKRKGVALKKGQTITGKVGYQKKSEKSRSLDITIEWDSQDGEKGSQKWGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBW5</accession>
    <name>A0A8G1RBW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_366244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518382.1">
        <property type="nucleotide sequence ID" value="XM_025655775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBW5"/>
    <dbReference type="GeneID" id="37159177"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="561" mass="62712" checksum="6D9DFB8E9F643318" modified="2022-01-19" version="1">MSTKFPTTTVTPIEMVSQAQVLDRSVPPQSAASSVSRHSHSSRRHRSSRSHHGGLTHQQQNDFPIFTHTGDVEIVVRAGDQERRYLLHRLILAQCSGFFEASTREEWSRQSMPRPPNLDTGVLSRISEDASSLSNGSTLAQSESGGSAWSVEKRRWRYELDWVNKEEDEEPILVQKPPSFSSAFGCDSGQYPPSVTKPSSSQTGFVRSMANLAGMQSVVNLPHRSGTAHPPTNPIVRDYDNLFRLFYNYPPLLNSVNIATAYAECRALLNLADMYDALPVTGPRVDHHLLGFGSRLFKQIAKYPPSYLKLGYLARSRVIFSEALIHVVGQWPAGLPHLRNGPYSPLPNSVLDIIEDKVEDLEDLKARIDSKLLRLTLTTSRGERVSPTNAYLDWLAVSLFRQWLVDSTTPPPTPILKNSSANAHASTSTHGIRSSQSTSHRPTDSTSKTTTTTTTTAAPPWSAARVYRLIGSSSSQAYLSHEDLKRFLKVHPTPSSESLYTREVLKRFERKMDEIKRLAREIVKPLMRNFLELDLKGSEYGEGGLPYLTCTKVDDEDIPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC00</accession>
    <name>A0A8G1RC00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_365314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518427.1">
        <property type="nucleotide sequence ID" value="XM_025655736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC00"/>
    <dbReference type="GeneID" id="37159138"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH60505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="264" mass="29269" checksum="A5A74443F69CA0FA" modified="2022-01-19" version="1">MKRERQAYRHPGVASSACFRKMYDEIDSSTIALEWLDTTLAEVKYQPSMRIYSLIVTFMRAALTSCIVLEGYGCVNTDFKPANILLSGIETGYITAKVGDLGLVVPSGSLFNAQPYAMRAPEVFLGHACAEPSQVWAVAAMLLCWISPGVLGVWDSPHPFINDAWCMAKIKRLFPHWEIPHSDDVEGHSLKAAVDAAKSFSKEVSELQAISPLCEEIRKVEMPRQLRDLLRLMLVVDPVQRPSALSVLASEEFRALEIVTKGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC09</accession>
    <name>A0A8G1RC09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_444695</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGM family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521336.1">
        <property type="nucleotide sequence ID" value="XM_025659084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC09"/>
    <dbReference type="GeneID" id="37162486"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH63414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="419" mass="46310" checksum="F32CBE54774EB7EB" modified="2022-01-19" version="1">MASSSSFFQSPTLVYTSAIALRAILLIYGAWQDANSAVKYTDIDYLVFTDAARYVSHGASPYERDTYRYTPLLAWLLLPTSWTGPSLLFSFGKALFALSDVLAGWLIARSLVSAYGMDAPRALKYASFWLLNPMVANISTRGSSEGLLGVLVIALLWAVLRRRIVLAGVLLGLSVHFKIYPFIYGVSIIWWLDRERDGSSSALKNAAGSKDTSIVTKLINFITPPRIILTLTSLITFTLLNLLMYSLYDTPFLQHTFLHHLTRIDHRHNFSPYSTLLYLSAAGEVQGNFESLAFIPQLLLSVVVIPLVLAKKSLPGAMLAQTFAFVTFNKVCTSQYFLWYLIFLPFYLPGSSLLKAPRFGGVVAAAWVVGQALWLQQGYNLEFLGLSSFMPGLFLASVGFFAVNVWILGVIVQDVGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC54</accession>
    <name>A0A8G1RC54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_436223</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518502.1">
        <property type="nucleotide sequence ID" value="XM_025658565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC54"/>
    <dbReference type="GeneID" id="37161967"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.230:FF:000004">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF5">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="15">
        <location>
            <begin position="13"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="14">
        <location>
            <begin position="129"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH60580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="409" mass="43802" checksum="1B6F22F561AD51A6" modified="2022-01-19" version="1">MTSPSYSHHFSIHNLPYGIASSPSHPTPQCATRLHNTVIFLSDLQSAGLFSSIPSLPENIFSNTTLNPFAALPRSTQTQVRHVLQSILQPSSTSSLPESSTADITTVTMHLPVSIPSFTDYSASLPHNQHAGQIILNHPAPPPAFFHFPIGYAGRASTISVSGTPVTRPSGHFYDRTDPSFPQTKKVIFGPCRALDYELELGIIIGNPLPRGQGLKAQDAEEHIFGLVVLNDWSARDIQGLEMIPLGPLNGKNFATTISPWIVTLDALQPFKTPGPEPRVSLPAHLQDPGEFNYDISVVTELEAGSGGSSTVLGRGNAKDLFWSIRQMCAHLASTGCDLRTGDILGTGTVSGEEEGSYGCLLEVTEGGKKRVKLEGVDGEERGYLVDGDVVRLTAWAGEGVGFGELLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC84</accession>
    <name>A0A8G1RC84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_445170</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519692.1">
        <property type="nucleotide sequence ID" value="XM_025659192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC84"/>
    <dbReference type="GeneID" id="37162594"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000069">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="11"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="52"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH61770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="142" mass="15255" checksum="F74C72F6681B0A15" modified="2022-01-19" version="1">MVHAADHLSAQELETLSTKAIAAKDTAYCPYSKFRVGACILTESGEFVQGANVENASYPVGTCAERVAFGNAIVAGHRNFKAIAVASDIKPPASPCGMCRQFMSEFTTPEFPIFMYDGEGNYTLTTMGELLPNSFGPSDFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC98</accession>
    <name>A0A8G1RC98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_19592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="RAH63213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521135.1">
        <property type="nucleotide sequence ID" value="XM_025654474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC98"/>
    <dbReference type="GeneID" id="37157876"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF272">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH63213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="329" mass="35943" checksum="7AA049FDED64D5B4" modified="2022-01-19" version="1">MSDKYAAVRQPKGAGDARPTALQVIQDENLEGQWSDKVILITGCSSGLGVHTARALYATGATLYLTARDLDRAKTALGDMLDSPRVHLLSLDLNSLASVRACTEEFTSRSPRLNVLIANAGVMSCPEGRTGDGFETQFGTNHLAHFLLFHLLRPVMLASSSPGFHSRVVLLSSGSHRFGQVNFDNLTWEGEFDTWMAYAQSKTANIWTANEIERRYGALGLHAVSLHPGTIATDLLRHVPADQMVIWTADKELEKYWKTPEQGAATTVWAAVSPEMEGKGGVYLENCAVANAWVPAAGPWGPGYAQWAYSPESEARLWDVSLNLLKLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCG5</accession>
    <name>A0A8G1RCG5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_416513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518667.1">
        <property type="nucleotide sequence ID" value="XM_025657735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCG5"/>
    <dbReference type="GeneID" id="37161137"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="690" mass="77014" checksum="4EE43CB52DE3C7BA" modified="2022-01-19" version="1">MAQVGSNPLRHSDLYNRVQDWITKSDAAHNSHEPRDTSSLRHPPSYYLQPVSYAFDKDRYEEIKKMNAEPENMPASFAERQPGWLGWENYYAERGGVTVCYPSARKLQQARVGQVASLEPTGSQQPVASSTANDPATSSNSEERGHHRYERQPRHRTKTDRYEYKVQDKKISERPGSKKRTFNDTFHAPNVPCDRLTLSQRRTSGIFKRGKASSPIRTRSRDPSLGFLGFDTIANTDTMRASSGSDFSESDFLAKRNTNSATLMRLIDSSPRDVHRTSSLGSSYKSDVSDTASTVALYLSRELPRADHIVTESLEMNATSEPATDSCMSACGNSSSRNAEVHIEEHPNSLLANQYIIDDKSIEEGQYCSTRLQDGVSQKCKHSDTMRSNDVTERPSDEDKVGDQKIKERGTDGNIAAARVHDSTINQSALPNTSKCRQPTSEPRSRSVADTEDFDYEGVIGAKLRGTITPSYNQLSWSLIHGSSRKMSVMSDVGICGENPQGHQSQIRQRIEEPDYESLDFTAFPEANDCGSDMASLIDLEEWETASIIVDMDTELDTQVLSMPTSSAANRNITQEIQERLEATQLGTSILGEKPHYLWEARLERPSTALCSTDSMRDTPSTVKESQMRDASQLPIHDDESIESESRTTFRPGPWLESLSRRRGGAIGIGNGRLDPTDGLGTFWQQRMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD12</accession>
    <name>A0A8G1RD12_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-1,2-mannosidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_446188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518952.1">
        <property type="nucleotide sequence ID" value="XM_025659452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD12"/>
    <dbReference type="GeneID" id="37162854"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000002">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF25">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034164106" evidence="1">
        <location>
            <begin position="23"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="34"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="287"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH61030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="795" mass="87252" checksum="FD273F83F9937B0F" modified="2022-01-19" version="1">MINWKHLAVSVALPCIAGCANSSASVDDYDVLQYINPLIGSANGGNVFAGATIPYGMAKAVADTDSVNNQGGFAYDGSSITGFSSMHDSGTGGQPSLGVFPLFPYVTCKDDDVNGCAYPKKDRTTSYDSGSVKSSPGYFGLNTSSGIQVDMTTAHHTALFRFQFPVDKPSSPLILLDLSDLSDTRQDNGTISVDPTTGRMTGHARFLPSFGSGSYVPYFCADYHGTGDIRDNGIFVDARASVDVKNLTISRSINGYPLPGGAFIRFNSSADNVIHARVGLSFISSDQACQNAEAEIPDFDFNKTQTAAVNMWTEKMAPIRVSRNGINSSMLTNFYSGIYRTMVNPQDYTGENPLWDSSEPYFDSFYCLWDSFRSQMPFLTIFDPASLTRIIRSLIDTQRHLGWLPDCRMSLCKGYTQGGSNADVILADAYAKGISDGIDWDAGYAAVVKDAEEEPFDWSNEGRGGLMSWKALNYIPVEDFDYIGFGTLTRSISRTLEYSYNDFTIAQMARAMNKTGDAEKYEGTSQYWQNLFRADQTSYLNGTDTGFQGFFQPKYLNGTWGSQDPLTCSNIDTSGRSCSLQNNGAETFESSIWEYQFFVPHDMSTLITLLGGPTQFIRRLDYLHDQGITYIGNEPAFLTVFQYHYANRPGKSTARAHYYIPRYFNPTPTGLPGNDDSGAMGSFVAMTMMGLFPNPGQNVYLITAPFFESVQITSPLTGKTATVKTVNFDATYQNIYVQSATLNGKPYTKSYVGHEFFTEGQELVLVLGRNESDWGTGMGDLPPSLSTKQVFGVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RFH8</accession>
    <name>A0A8G1RFH8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_132747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520272.1">
        <property type="nucleotide sequence ID" value="XM_025654003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RFH8"/>
    <dbReference type="GeneID" id="37157405"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="874" mass="95539" checksum="6AA4A1A944085593" modified="2022-01-19" version="1">MAIPAHPAGTNGQVPVIAHSSPAAEPSPTFTVNSSSDSEDPNLPDAVREDEANEVVGVSMSRAQSRMKARLTPAEEKTRMMERQSSYFDTIPDTPEPEGLFASEITDEPEALPEEPAAKPGDAQASSADLAAPQRDSARGSKDGQRTSFTRSILKSGLPLRPRAWSGDSLTNIRLKKFLPDLLTKRSSLSFRPGSSSQVRARSQTLKPMSKLALEQEKDESALQSRRKSFSDPESRDSPEEQVSELDPLGGATTARHSYARRPSTTGRPPSLLRRSSSDQSLYLRASSTASSLEQRPRYEHIHSQVNSRFKAIKDSLQDSSSRLLSMPTLHLQDFRSDWGYKPFLSDVTNRRGHTYATPEQPPSAREMPGDDSIPPRARSPRTSISAQYPNLTEAMAEMTGDVVILGGYRGSVLRSAKPPQRQLWVPMKVGLNLRKVDLEVGLNPEDEERMEETIIPSGVLSHVGPVDICRRLMKRLQKCPNAVNGDLRVHDYGYDWRLSPHLLAKRLVKFLEGLPCNSPDVPREKRGAYVIAHSLGGLITRHAVNQRPDLFAGVLYAGVPQHCVNILGPLRNGDDVLLSSRVLTAQVNFTFRTSFALLPEDGHCFINKRTKEEYRVDFFSAQAWDDYRLSPCINPALPLPNSRGFKDNLPLLGKRISTVLGSKDSLSSTDDANGEQASHNHTQNPNETANPSNESTGKYAPVSAPNLESAVGPTSNFKGSANTKATTTTTIPRATAVTYLERTLAEVLRFKQELAFNSSHQSQNKYPPFAVLYGKSVPTVYGARVESRERIPYQDAYDDLAFAAGDGVCLASAAMLPPGYRIIKGGLVKSDRGHVGLLGDLEGVGQCLLALVRGRQEGVGLGGESSQQQSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VG53</accession>
    <name>A0A8G1VG53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Trimeric LpxA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_454430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509798.1">
        <property type="nucleotide sequence ID" value="XM_025661285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VG53"/>
    <dbReference type="GeneID" id="37164687"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF54">
        <property type="entry name" value="ACETYLTRANSFERASE, CYSE_LACA_LPXA_NODL FAMILY (AFU_ORTHOLOGUE AFUA_2G08430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH51876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="146" mass="15189" checksum="4D527E4EDE3B2705" modified="2022-01-19" version="1">MDYGYNVKVGEGAFINFDCVIIDTCLVTIGARTLLGPKVSLYSGTHPLDPAVRNGTEGPESGKEIHIGEDCWLAGNVTVLPGVTIGKGAVIGAGSVVTKVRSRLLTIPGILCEGQKWSLLISMVAMLGCSCVSFGCGKPSESDSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGX9</accession>
    <name>A0A8G1VGX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_442819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510681.1">
        <property type="nucleotide sequence ID" value="XM_025658853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGX9"/>
    <dbReference type="GeneID" id="37162255"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852:SF1">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852">
        <property type="entry name" value="YALI0B21208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="204" mass="23217" checksum="0CAEC41B5DC93914" modified="2022-01-19" version="1">MVDKGWDRLKGHEDSLLWKIWHWDRFFEADAPPRLGIKLRKRIQYMSTSAFSAGLGIGYMHGSKTAAYRFRAENAHRFPDTARGWYQYHKSKNYQAFLQGSTQGLKMGFKLGTGALCFCLLEEVVDYARHDQRDFLSTVTAGLSMSGIYSVLARQDIYTAARSAKTGLKLSLAYGIVQDVLETWQGTRPAYVDIILGSRRSRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VH50</accession>
    <name>A0A8G1VH50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin C-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_432611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509799.1">
        <property type="nucleotide sequence ID" value="XM_025658386.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37161788"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000136">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021905">
        <property type="entry name" value="DUF3517"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12030">
        <property type="entry name" value="DUF3517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1604"/>
            <end position="1933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2498"/>
            <end position="2521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH51877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2521" mass="284085" checksum="4A98AC3365B09767" modified="2022-01-19" version="1">MAAAPLESSSTPPETTSSIDSTRPLGHPMEESDPQSTRKRPRLDSGSGTCESRSIPDETAATRFPNDIPDAPATTGQDASPSSRPASRVVIKLKSPVPNDNMASEPGDSPVEHPSRDLPTQSAAGGTGLDASTAISLSSSPTQSPEIEVADLEDMDQDPNTSSWKSLGEAMREPETPEVVQLHDQPPLVETFPRLFMGNETRENLEEICTMIEKGSQHDTPVFVAVKAWFDDVANNLDQLTHEVLAEDRDFWEELPSVVDSLLRRVVELLPDEGRGVWACLEEFFLDFAHLAVHVIDLDTILLTQAVDDAEAQITDPLSKPYLVSLGWILQLGNIPFFRTMENIHGSDVANLVARTNDQVAAALDIIQHLSDHAACILNLITRWSQLSTSLIAIVNIVHNLIESGNERRRYHADDALINSSICSRTMRRAYPLIRAADEKYQFHITKKSPWVSSETSDSMLRHIAFSYTTLCNRDLELASQIAEDLAIELSEDVTPEDRSSIIFYGWKFGVLKKHIMDGRMELRVFGVETMQAELVHIWRQHIHRNTEGTIHPVVDYLVGFLRQNRIVEYIVGIDSHPQLISRSGNIVGFLVVTATYTDADTDTIWETVTESPDPRTVSEVLGMLSKTFQMHTSNSPALIYVCSKLLDLPLARFDARMVDFCEQLLHQVREKCSDRSHRETQNRIHADAIPLRLCVRLIRESAGANDFPVEHKALLQKFAAAQLKSFMDIGLSEVDKMEIYEQCLKDIAEMNQFTVGSIQALNALLPSNDSLELRKLAEEFDLTRLVITELAHTVDLNQTDFTDPFSLTGFSSRVHMLARIIDMVPDSITPDLGDLLWRRVFMSKSLAQQGRRALWDMLCATARYSAQANSLVERCIQVYLPELSPAEDYLPEVLQFAKQTINYEVRFNPPSIAGENEVVAIPGMDRIWSFILTAPPGTIETDAITFAIEVYLDHSIINRSPRSAVEATHIALVDRCVDQLKSAASRLKESRDNSDIIQDASMDAVASDTNIKAEELRFSRSLLFLRRFLQGLRCRPQYSPPQSLPLDSPGKPIQGDAIDIRYQTFNGGTQSKVRSLHIGGLSTAAELAETLVRVTGFTKFSTISGGQRIDLLEKPGITIRDLKLGSGLLLIRRDPESRELAMTGRRQSLTLVDSEVLKHFDDLYDLLVLEDHLAREIYDFLVVFPPQDRVLELVKSTDKTEDEMFPMDKPFSLLYSVNALSVSLREETLEASPNQDYVSHSIRVLVSALTRSEMAGGLKDSPTKLLSATHMVECLLYALLVRPAIPGEAPVVPNPTALVQRLFHFMEVARLLPISSPSETSITKLICNSFAVLTEGSVRDLGFWEAVKEQPHFDELLCSLLLKEHRQPIRKGIAENIAVACSPSKLLRKSTKPIDPETQGTQDTPASDNAIRIEILAKIWNAFDKAFPVTLDNAAQCQEFFEIANLVFRSVAERSPHDLSFSQYLKQWSTTMLRHQTEEFVGREPVDHLILGFARLLRICLELAGSNDTTVDTFDLAESLFDQYLFPDLSSPSTDLIVPQVPVMHTQTRQELYSILCQLCRLDENNYSTIVERLEDLIPLDYTYSPAWGFDRYKMLRSPEGYAGLKNLSNTCYLNSLLTQLFMNVGFRDFILQLDLEDPDGSQKLLYETKKLFGHMQETWSKSVDSQAFVDTIRTYDNEPIDVTIQMDVDEFYNLLFDRWEAQISDNESKKRFRSFYGGQLVQQIKSKECPHISERLEPFSAIQCEIKDKASLEDSLQAYVEGEIMQGDNKYSCTSCGRHVDAVKRACLKDVPDNLIFHLKRFDFDMVTMLRSKINDEFQFPDFIDMSPYKVEYLSDQTAEVKEDIFELVGVLVHSGTAESGHYYSYIRERPTSGAGGSWVEFNDSDVSRFDQAKLADQCFGGHNDSGQSSAMGQVRFNKVWNAYMLFYQRASSMEAEKAIYKPTKPQHPVGVSLPRELANHIVMENEIFIRVYCLMDPYHALFVRYLLSMILEEQGPRSDTKAKLDKSMIFIALDTLEQLLSRSREPLGLDAFVTLLFTVISEVPMAAYRVMQWFESKPSATRNLVLRSPHPAVRSNSIRLIICSLSKLQGLQKGADDEDVEKEVWKMRYLNSFENVVRTLESMWSTLHTASRSWDDYFEFLSMLANFGQYEAGIILNNGFLLKCLEIVWLDHEDSKRLRRQYAFIIKFMEKGRRFSYKRLMDLLAYLIARIDLTVPPSQDDKRRTLPDGRYTLTMSEAMFIRPLGKSKELSFLTTVLTHNSSPPASRNIVTLFVDAEPDAGLMDPICRTLEEGLRLAPASLCAPFLEATLIFCRRGPDEARIVSLIDFVAKGVDSINDSGGREHIVFFTSVMGSRNNRLGLNEAWFLNHLIEMVPEWAPPLLTFPDRGVRNMTLDVLRQILFSGEAEDAGDDWQTRQAEVAKKLVHASINRLRKAYVNVPGSGVDPRAVESIRTVVEHCLSTYFGDSEEDQEAILQAQETIAAVEDLIAEVPEELASEDWEDNSVMASDSEMGLAGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHH8</accession>
    <name>A0A8G1VHH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_157170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511311.1">
        <property type="nucleotide sequence ID" value="XM_025654201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHH8"/>
    <dbReference type="GeneID" id="37157603"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24666">
        <property type="entry name" value="zf-C2H2_fungi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="181"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH53389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="367" mass="40381" checksum="649D9DAB8C191609" modified="2022-01-19" version="1">MTTQRFPTRVPCTYKECSGVFTSAGEMKRHKANEHDYCSRCDEDFQDDEYLLLHKIKSDKHIVCVVCGIDFRSEGGRDLHTRQQHRTPQTLTCYGCGQKFKMAGAMVNHVESGDCPNIPLSSLLQEQSKRLLFREALKTGNEGESAEPDCQDGGVHIDQDLLEMDPDNEATQSVVGGVSALSLDDIPEPKSKSSMASPSSVSETREQSTSAGKIARPSSPSPGPSNSFGIDHLDAGYTLRALDRNWDPTVYFSSFHGKFICPCKAEFSSMRDFEEHVVTKTNQNRGIQCPGCLRIFRTAAALVAHCESASTRCKVNRGLQFSQVINDISGGLVRSVGLFADGSVEYGPGTMGPKQVTYEKEQRSLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ52</accession>
    <name>A0A8G1VJ52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_452779</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511854.1">
        <property type="nucleotide sequence ID" value="XM_025660905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ52"/>
    <dbReference type="GeneID" id="37164307"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="13">
        <location>
            <begin position="34"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="212"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH53932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="383" mass="41824" checksum="83BFFEFC2469450E" modified="2022-01-19" version="1">MPPPHTPEHFHGYLSHSPTTPLTYAPYTPKPFTPTDIEINITHCGICGTDLHTLRSGWGPNTTTYPCIVGHEIIGIVTRIGSSIPTHPNTTPLRIGDRVGIGAQTHSCLQPSCEECVAGKENYCPRITGTYNSRYWDNETGKRSDVIAYGGFARKWRGPAAFAFRIPERLESEVAAPLLCAGTTVFAPLRKYLGDGADSGKGKTVAVVGIGGLGHLGIMFAKALGCERVIGISRSNGKREDAVKGLGADEFIATGEEKGWEKKWSRTVDLILCTVDGDDMPLGKYLRLLKAGGTFVLVGAPEKPLPRMRAFELIGKGVNVTGSNIGSREDIRCMLEVAAEKGVRPWVETRRMEEVNETLRDMEAGRARFRYVLVNGEERESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJF7</accession>
    <name>A0A8G1VJF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maltose/galactoside acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_383445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510625.1">
        <property type="nucleotide sequence ID" value="XM_025656519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJF7"/>
    <dbReference type="GeneID" id="37159921"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF23">
        <property type="entry name" value="ACETYLTRANSFERASE C18B11.09C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH52703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="144" mass="16399" checksum="85BD8EEF38B29ADB" modified="2022-01-19" version="1">MEPSTEKNLGLIETAKSLANTPWCEQYERMISGMLNNTCKHNTQDLIHKFRYDPLAPELMQSRYRARKLMSKYNAPIPDGISFDDLTQQREDLLRQLLGQVGKGTFIEPPLMVDYGCNTKIGDGFYANFKYAVSTPLLSLFADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJL0</accession>
    <name>A0A8G1VJL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">37S ribosomal protein Rsm22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_407318</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510775.1">
        <property type="nucleotide sequence ID" value="XM_025657359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJL0"/>
    <dbReference type="GeneID" id="37160761"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="679"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="782"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="690"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="782"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="801"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH52853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="858" mass="96774" checksum="F16DEC99ADD9A366" modified="2022-01-19" version="1">MLSRTPAVRATRSNPYALLRPAVSRSPQTGSQSLRRGAASFITGRPRTSIARKAFPSTLHLESLHREATYARSQPWVHSRRHASSTTATETDPDAEKKDAIYALVDKINETDLEMAELMHELDLLDDHEKALNLEGLDFDYALSQTIGHRDEETLDARVREARQEFGEYLPEGLLNDRETQLYTRLYGEPIYLSQESELDLVEEEIDPDKLYREDGEGGWEEVAMDESETHDEPPLVYDMEAPPSVEETIAMQRTREVAEQLGGEIMLEQFEEEAAADSAPKFHPLTTMGKFSTDPSTIFIPKDSVTGPISVILSDFSNKHIADTAHRTLGGQYLPYSTTTPPLRLQAPQQPIPLEASQRYMSEMEANVFLAALYPGMYASVLSVLVEVRKRLGTDWIRNLMTQEGGPHVLDVSAGGAGVLAWRDILRAEWEAMTPEHSSEDPYPVGRSTVVTGSDSLRLRASAMLEDTSFLPRLPDYVHVREKPTLQDERAPPKRKQYDIIIAPHSLLGIEEEFLRKEHVQNLWNLLNPNGGVLILLEKGHQKGFEAVAGARDMLLKRFISSPGSTTYENLTESPEEDTFIEKEAGMIVAPCTNHNKCPMYQIPGHTKGRRDYCHFQQRYIRPAFLQRIIGAKDRNHEDLKFSYIAVQRGVDRRVEDSIIQGTEAADAAFDGYEDAVEMPKQEAEASSDEAVASETQPTPPTEQQETGGVNFLSLPRIVYQPMKRRGHVIFDLCTPAGKIERWTVPRSFSRQAYKDARKSQWGDLWALGAKTRVARSLRLGEKHGESRKERLARRAAEKEEMEEDAEDALEEGMEATSSMPDLQTPIKKKGQKIPSWEKQQMKKKRRQALKQVKPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKJ7</accession>
    <name>A0A8G1VKJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_55540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514538.1">
        <property type="nucleotide sequence ID" value="XM_025665480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKJ7"/>
    <dbReference type="GeneID" id="37168882"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="75" mass="8697" checksum="4173F4D244D12036" modified="2022-01-19" version="1">MAGYIGVGMFQMKLVFYSILCFFPYVNLTLRISDGMAKFIILAIVYSLASSSRVTLQVTRMLYVRYWIFLGHVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL42</accession>
    <name>A0A8G1VL42_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_55692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513924.1">
        <property type="nucleotide sequence ID" value="XM_025665483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL42"/>
    <dbReference type="GeneID" id="37168885"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF5">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="2">
        <location>
            <begin position="22"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="328" mass="36965" checksum="405F0015825ACDF9" modified="2022-01-19" version="1">MWDSLSKPPEGLIGGYQGGSMAIKILMAVFCAIALYNAVELVILIFLTFTRYSGLYFWAMLLSAVLGVIPQAIGFLLEFFAIGPLWFAVTFSTLGFYFMVPGQSIVLYSRLHLVVQSQTLLRRVLYLIIFDTIVLLIPTTVLTYCTIYVGTTPVIRGFNVMERLQLAWFCAQEILISIIYIVETLKLLRLRPEKDAERHKTMYELIAINLVIILLDVTLLVLEYVGLYTLQTTLKAAVYSVKLKLEFGVLRKLVSLVNTRPAESSSSDQETYPTFVDPNQITGDVTRAAPAYSRRQSQYPWAAISMDSLALSDRRSQHVTSSEIERPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL87</accession>
    <name>A0A8G1VL87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_51208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514402.1">
        <property type="nucleotide sequence ID" value="XM_025664638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL87"/>
    <dbReference type="GeneID" id="37168040"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH56480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="59407" checksum="CBD61ABF30D9653A" modified="2022-01-19" version="1">MLRVLIASGDRKAVAVKESLNALDFHSHLSFLDNRESISHGRPSIWHNTASELSVIHLEGERIHHLMENDEQLHTHLINMTSNDMTMRDLPQIGCPYCFPNCYSIFEPERTAAAAHGLQFLSEEQSHHNKPQEIMHFVKVEDGCQFEIFDAHPHVPQTSFADDNLYSSDAASDINHQADDMNDHFAVSEPVPPLMAEGETPLRAPITILDECISQSSAPLLEGDWTSVEEVALSESQRSSLEIPAPAADSILDTASTSLPLLAAQVHQLSHSASEDTSSGLSIWDAGNLSNEAQFYGEINSALAQLAAANIHLDPSTFENDGSSAAQSLLLPWGSQRADCPAMLSIGSGCAANQRCNEFFPITNPYLHHESRYRPNEPWPLPSSSDISHVNQGKLLGRPLTCLRDKRNAFLIDCKLRGLSYKDIKRIGGFKEAESTLRGRFRTLTKSKEQRVRKPQWHQNDIRLLCEAVNVLSETTSHDKSRYSFCWARIDNHLPKVSWKRVAQYIRAHGGTYQFGNATCKKKWCEVHGVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLQ8</accession>
    <name>A0A8G1VLQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Decapping nuclease</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_284852</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515768.1">
        <property type="nucleotide sequence ID" value="XM_025655234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLQ8"/>
    <dbReference type="GeneID" id="37158636"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="22"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH57846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="368" mass="42544" checksum="2D4F1FE0522EAE10" modified="2022-01-19" version="1">MDRKAFDIQPIGRFYEASAAIRRPKEIACFSYDDEHKFHLGDSSMKYYYPPCLPADLNRGFESFQKLDDSADEHLDALLETIMALEQETQKKCEADIITWRGMMTKILAAPFDNLNGFEMNATCFQGTIFIEENNSYKNEQKRVQKNQRMPPGMASQDLMAYWGYKFETLSVLDQPWDPTPRRDIENREELIVNNNAQYCSVVRTAIGRARLVIGGEVDAIWDCKPERKEDPIHWVELKTSAEIRNDRDMVKYERKLLKFWAQSFLLGVPKIIVGFRDQQGIVHRLEELETAAIPGKVKKLGRGTWDGNICINFAATFLEWLKTTIQEEGTWRIRKREKSSLIEVFKVEESGTGDIISPAFSAWRSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMP1</accession>
    <name>A0A8G1VMP1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTPase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_69001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513820.1">
        <property type="nucleotide sequence ID" value="XM_025665596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMP1"/>
    <dbReference type="GeneID" id="37168998"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05137">
        <property type="entry name" value="RasGAP_CLA2_BUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="505"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="725"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1112"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1129"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1166"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1192"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1239"/>
            <end position="1255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH55898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1255" mass="140753" checksum="B12857FF80AE366C" modified="2022-01-19" version="1">MEPEGSSGFKRNSVHQGIYSRPVERRPSKKSSSKDRHGMVYPDSFRDTGIRTVTPDSEAGNHSPSSEAEYLASSAAASPRPATRTRASDRESRRDYHSYHSAGDEEDTHVEMKSQRARSRTTTLDDQRSEISPNTFFRARNRLGSINTAVPQPKTPDESSSIGFPSIQSPTYFSHSLGRQRSSKPPGGSSLVTSVSANQTPSALSTTDASKILQLMKTTCGRMHGILSFRTASTTAWSSGYCAINVATGSLIYQAKGEPALAKTLIPDLRGCQVRSLVDPELRTNYLSVSTFTSGLGVELRPHVSETFDSWLAALLCWQPIRPKGVQNKMTKPQSVAIGDRRLVERRRNSESTVQKEAAIIKVGKMLLWDRPSASGVRPSSGRRVSTYRQQRALSSSWLRVSCTLQENGAFKLYTESDITLVTCIQLSQLSRCSVQQLHSSVLEDEFCIAIYPQYAVHSASGITRPVYLALESRVLFEVWFVLLRAFTIPELYGPETCAEDDPKSPSDAAASSMADMFRIERMLNVRVTEAKLLRNKAAEKAPRSRKQSRSHSNSTPTSAVSDYYTEVLLDGEIRAKTAVKYRTANPFWREDFNFSDLPPVLSQVSILVKTISPTQKDWTLIAHGSYGQDHSNPARLLDDVELSSQDATFGRVDLKLDDLQPGVETEKWWPILDDKDQPVGEMLMRARMEETVVLMSHEYTPMSEILHSFTNGLTINMSQVMSSELNQLSEALLNIYQVSGTTVEWISALVEDEIDGLHKESTANRLRYTTRIHSNDSRESGQEREVLVRDMGRTATVEANLLFRGNSLLTKALDYHMRRLGKEYLEETIGERLRDIDETDPECEVDPSRVHRSDDLERNWRNLVSLSTGVWKSIASSASRCPAELRLIFRHIRACAEDRYGDFLRSVTYSSVSGFLFLRFFCPAILNPKLFGLLKDHPRPRAQRTLTLIAKALQGLANMTTFGSKEPWMEPMNKFLVSNRADFKQFVDSICAIPADRPAPIVTPSYATPIQILGRLPPTSREGFPSLPFLIDHARSFANLISIWLEIAPERLAEMEEIDPAVSKFHEMAVRLHQRTKECLSRAEQAERPNGGLEVKWEELVDAMERSVTFYEDSSKPTSPATEAAIAGSTSLTGSHRNSIGYFASRPSLPRRSTDYAPEAEDDTPPSSSSATWDQSRVPFSIPRWADPRDSTGSSKNSSTYSLEYPEPSKSRRSSITRETTSKYRFFDFVPPSRRKAKDREQAQHSREEQRNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VND9</accession>
    <name>A0A8G1VND9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_419201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516414.1">
        <property type="nucleotide sequence ID" value="XM_025657849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VND9"/>
    <dbReference type="GeneID" id="37161251"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="686" mass="77091" checksum="0431907896DEFEF0" modified="2022-01-19" version="1">MPPASTPTSGPSPPISKRRKTRKGTFSCWECKHRKRRCEFEPLKGSTCLYCQSRGIPCISQEHVDPRSRSSASQLSERICHVESLVDQLIRQRDSCQPQVQPPAQSRDRASSPRPKEALILSPFQQLCKSLAAVLPHPNTAALILTKGRFFSLPFQTCRSPVRDQSAVFSGLEQSGDVSRLPLPTSHPIQYAQKLIELALGLQQLDLTSFPRPQLQLQLNHSTGHSSRRYLDLAARHVTSQDTLVDSLDGLDTLLLEARYYINTGELHSAWLIFRRALSIAQLIGLPRKSDEAESRAASLWIQLVYNDRFLSLMLGLSCEVKDIELLDRETLNKYSPLRKLYRIHAVIAGRIIVRNVHMQHCDQLSQSTYDHYAVTRGIDDELRKETRSVPIDCWKVPTLESTLSDTDKMDRVSMLITQMHQYYLVILLHQPYLLLQLRNHTELSRSALSCILPEYSYSIQVVVPASREVLSRCLEFQNIRPILSYRGLEHKAFISAVTLLLSHILGHRSGSENVLEHQRPQDLAMIQQAIDTLAEVCTMDGPNRDSAIKTRSWLSRLLDIEAEAADGINYIACIERDNVGPDDALCHTSHQGLRFPIPYFGVICMIPEPVPDLQSDGQLSESAQAIGPDTAQLGPCLDSHGLPSTVTELDIGRGLHSQLALLSDVQSELQSLFDWTGDPNILYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNU4</accession>
    <name>A0A8G1VNU4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_476670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516864.1">
        <property type="nucleotide sequence ID" value="XM_025662796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNU4"/>
    <dbReference type="GeneID" id="37166198"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="113" mass="12112" checksum="BA7A147B0EB4E6DF" modified="2022-01-19" version="1">MTGTNFNSRGGTQANNVNNGSGSQNNNNGSGMQNNWTGPDATVNNNNGDGKSSPGGSQGRNHRQDEGGYLRGNGISTWHSQSVFATMFEPYDQCPSNEDINLRIHCQEECGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP74</accession>
    <name>A0A8G1VP74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mcm2 3 5 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_519125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517269.1">
        <property type="nucleotide sequence ID" value="XM_025665022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP74"/>
    <dbReference type="GeneID" id="37168424"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="744" mass="81354" checksum="E459A09B35671E6B" modified="2022-01-19" version="1">MAARSSDGLRLLSDVNIPDARLHDDSSGEDDKSVIDLRDLGPGPRDSFRSDLTDTPPKGVDHGDQPHSLPLPTNKSRRRCSGLFVTLIVLGVYTTILSGVFFVVACIKPYYGSLIGNNARLTASSASLLSALLAKTIELSYVTICVAFLGQLLSRRALAHGSEGVSIADMTLRTWITQPGSLLMQWDVLRYVGWTTLGGLTLIVALVAMLYTTAAEALVSPSLVMGPIQPRLLQGNVFTEYSNPYYLEDACQTPITVDVDPTHWNETCLEMEIAGRSYHDYYQYLQGWAEMLKAGNSTSTALAYRPQPHALLYDNTTVTGRWIEVVNTTALSEQHGRVVNNVTAAYPHGGLFAAARNPANKIQQPVDMSGEGKYIIQASLPSPAINVMCVGMSHDELKPLIYTEWPNHKPFNASTWATAAPTYSINTNRTVVDDLFGFSEDQGAPVFPIYPKAYNTILNPKVDNTTSIYILGSAPPGHDPKYVLCGLRGKLSGRCSAQYQVDPSGGDLSSRCEDAADRMQYNRIHPNTSEDQYLINWKSVAWEWADTVTLASGIQGDDAAIERTLMELVPSFDNTTNSSSLDPRLPSLSEALAVLAGSTALLGSQYSAFVPDWNYSTPSLDTPVVQVFNATLQSAGYASGRTSDWQQVFYVILAVVFLTNIMCLGFILFQGRGQLVTDFTEPPNLFALAVNSPGTVHAFSGAQLGAAGTPRLRDRWHVDMREESGHYYIRTHGQLQHFEDRAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPY5</accession>
    <name>A0A8G1VPY5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">saccharopepsin</fullName>
            <ecNumber evidence="12">3.4.23.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aspartic endopeptidase PEP2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Aspartic protease PEP2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO85DRAFT_446872</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Vacuolar aspartic endopeptidase which is probably also secreted and contributes to virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolysis of proteins with broad specificity for peptide bonds. Cleaves -Leu-Leu-|-Val-Tyr- bond in a synthetic substrate. Does not act on esters of Tyr or Arg.</text>
            <dbReference type="EC" id="3.4.23.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.25" evidence="12"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518242.1">
        <property type="nucleotide sequence ID" value="XM_025659600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPY5"/>
    <dbReference type="GeneID" id="37163002"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05488">
        <property type="entry name" value="Proteinase_A_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000036">
        <property type="entry name" value="Vacuolar aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033819">
        <property type="entry name" value="Saccharopepsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 17 20" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034948156" description="saccharopepsin" evidence="18">
        <location>
            <begin position="19"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="19">
        <location>
            <begin position="85"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="116"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RAH60320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="398" mass="43349" checksum="CBD89459549572CB" modified="2022-01-19" version="1">MKSASLLTASVLLGCASAEVHKLKLNKVPLEEQLYTHNIDAHVRALGQKYMGIRPSIHKELVEENPINDMSRHDVLVDNFLNAQYFSEIELGTPPQKFKVVLDTGSSNLWVPSSECSSIACYLHNKYDSSASSTYHKNGSEFAIKYGSGSLSGFISQDTLKIGDLKVKGQDFAEATNEPGLAFAFGRFDGILGLGYDTISVNKIVPPFYNMLDQGLLDEPVFAFYLGDTNKEGDDSVATFGGVDKDHYTGELIKIPLRRKAYWEVDLDAIALGDDVAELDNTGVILDTGTSLIALPADLAEMINAQIGAKKGWTGQYTVDCDKRSSLPDVTFTLAGHNFTITSYDYTLEVQGSCVSAFMGMDFPEPVGPLAILGDAFLRKWYSVYDLGNSAVGLAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPZ7</accession>
    <name>A0A8G1VPZ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_446482</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy. Required for the switch to necrotrophic growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. Interacts with ATG24/SNX4; the interaction is direct and plays a role in mitophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519248.1">
        <property type="nucleotide sequence ID" value="XM_025659512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPZ7"/>
    <dbReference type="GeneID" id="37162914"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035632">
        <property type="term" value="C:mitochondrial prohibitin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="25"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00053189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="279" mass="31032" checksum="41DA6C07B0597762" modified="2022-01-19" version="1">MSTLLQQVYRLAVPISAGVYLFNSSIYDVRGGTRAVIFDRLSGVQEKVMNEGTHFLIPWLQRAIIYDVRTKPRNISTTTGSKDLQMVSLTLRVLHRPEVPKLPAIYQSYGIDYDERVLPSIGNEVLKAIVAQFDAAELITQREAVSNRIRTDLMKRASQFNIALEDVSITHMTFGKEFTRAVEQKQIAQQDAERARFIVERAEQERQANVIRAEGEAESADIISKAVAKAGSGLIEIRRIDASKEIATTLANNPNVTYLPGNDGKEGGKSTSLLLGLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ25</accession>
    <name>A0A8G1VQ25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_435674</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519323.1">
        <property type="nucleotide sequence ID" value="XM_025658539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ25"/>
    <dbReference type="GeneID" id="37161941"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF22">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="39"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH61401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="492" mass="54530" checksum="EC14E5E237CB7791" modified="2022-01-19" version="1">MASTPEKTIEADEKAASPSTSSVTNINEKALLRKLDFRLLPPLTILYLLSFLDRSNVGNARLEGMATEIHMSGDQYLTGLTLYFIGYVLFEVPCNIVLKKTTPRIWLPTLTLVWGIVATLLGVVQNYAGYLTSRTALGIAESGLFPGVVFYLSMWYKRNEQHYRVALFFSAASLAGAFGGILAWGIAHMKGLGGYSGWRWIFILKGTIKEGLLTVLMSIGAYFWVYNYPSTAEFLTPEERQFIQFRLKNDNDSTRDEQFTWSAVFDAFKDIKVWLYGLAFHTMSLPLYTLSLFMPTIISALGYTSAQAQLLTVPPYAVAFVLTITVAILSERTHRRAPFILGSTALACIGYILLLTDHRPGVSYLGTFFAAAGIYPAVAIVLSWPANNVSGQTKRCIANAMQISIGNLGAVLGTQLYRTETSPRYFLGHGFALGYLVANLVVVGVLWEVLRRENRAKAEVREREGMEALMGGVGDAEGDFLGDRDPRWIFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ92</accession>
    <name>A0A8G1VQ92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_468192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516445.1">
        <property type="nucleotide sequence ID" value="XM_025662240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ92"/>
    <dbReference type="GeneID" id="37165642"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057571">
        <property type="entry name" value="SDR_PhqE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF1">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23441">
        <property type="entry name" value="SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH58523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="288" mass="30350" checksum="91B8A4A4BBD975E8" modified="2022-01-19" version="1">MATPSLISINKLANTRVLIIGGTSGIGFAVARAALEHGASIIISSSNPQKVSSTVSRLQNLYPNKVYTDRVTGKPCDLSDQATLEKNLLDLLDYATSRSLFPNIASPTKYNDSSERVLLNHIIYTAGTPPPRIPISSPEINAISFAALSTLRLHAPMLLGKFAKKYLVDNHTSSISFTSGLMAARPAAGLAVGGAAVGSALEGLTRGLAVELAPIRVNVVAPGAVETEVFERLGPAREAYLEAFRKGTLTGEVGRPEDVAEAYVWCMKDGFVTGKRVESDGGALLKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQX8</accession>
    <name>A0A8G1VQX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA (Uridine(2843)-N(3))-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_475424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519247.1">
        <property type="nucleotide sequence ID" value="XM_025662723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQX8"/>
    <dbReference type="GeneID" id="37166125"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021463">
        <property type="entry name" value="Methyltransf_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11312">
        <property type="entry name" value="Methyltransf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="52570" checksum="89AA423BEFF36271" modified="2022-01-19" version="1">MAPPRSGNTSKKPNKKESSKKKPSSSSQAQPRRTTSKTDPNQHHHAAHENHELNISTTIPLTLQQLLLNVFKTALLTNGHNYLYNREETKQNDDDAAAAATTTEATGDSAEQQQQEQLDIKSLIQTIKTHLYNRDFDSAFTDANEDLLRAYALRWSSSRALGYAGIFRALLKEVIKPVSKDDDDDDDDAAAAASTKNVVCIGGGAGAEIVALAAAWRDILDGAELPSSSASGEGQIADAVKAVSLDYGKEEKEEEEQLTSTSTSATATSTYPGLSVTAVDIADWSKVVERLSTAIRSPTVTGSKSHPAPLLPSSGDEENKKKTPGFNVQFEKIDVLSAGEKELQGLFSQQGAESCSTVLVTLMFTLNELFSTSMAKATGFLLRMTDLLRPGTVLLVVDSPGSYSTLKLGKGGDGEVRERQYPMKFLLDHTLLSVAEGKWERLLSQDSRWWRRDAARLRYDVGEGAGLEDMRFQVHVYRRVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRF8</accession>
    <name>A0A8G1VRF8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">JmjC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_445223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519744.1">
        <property type="nucleotide sequence ID" value="XM_025659206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRF8"/>
    <dbReference type="GeneID" id="37162608"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="170"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="326" mass="36730" checksum="79C07D582D220C9D" modified="2022-01-19" version="1">MKLQQCLPNNNLRVWHRLSSVTLRFSSNQLRQQRCFTSTTSRPYRPLDTLKDVDIDDFRKNYFTPERPTILPRGSFRDFPAFERWFQPAPTDPNVSQLNTTYLAQHGADAFVPLELTQPSSDSTDEAGADGLTFQQFHAPLSLFLDWIRTAETLETQSARLYLAQCQLLDLPQVLRDDFPTPELVAQAGKGDVYDTNVWIGHPPTYTPLHRDPNPNLFVQLAGQKVVRLLSPGDGQKVFGAVRRQLGRTAGREAAAIRGDEMMQGQERTLLEQAVWDEVKAVPGLDGYEAHLEAGDGMFIPRGWWHSIKGVGTGVTASVSWLKLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRU3</accession>
    <name>A0A8G1VRU3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_474773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520192.1">
        <property type="nucleotide sequence ID" value="XM_025662678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRU3"/>
    <dbReference type="GeneID" id="37166080"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="147" mass="16806" checksum="3D46556852134303" modified="2022-01-19" version="1">MGYTHYYGVRDTHSTEWVTAWPQLVRDAQRVVDATDVPLSGPTDDPRDDHVTVPLVDEIEGIDINGVAKMSHDPLIIHPKNIRSFEFVKTAGKPYDAAVGCILLRAHVLAPKQFHLRSDGSWDEMEWKLARNLYESLWPEQPLTRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRW1</accession>
    <name>A0A8G1VRW1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-methylcitrate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_444624</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521258.1">
        <property type="nucleotide sequence ID" value="XM_025659062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRW1"/>
    <dbReference type="GeneID" id="37162464"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4100.10:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.120:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006943">
        <property type="entry name" value="PRK09425.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF16">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="4">
        <location>
            <begin position="23"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="5">
        <location>
            <begin position="296"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH63336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="502" mass="55810" checksum="5A782BE9377A2886" modified="2022-01-19" version="1">MSPLQHAAPVVPGDKPYDPEIKDMADYIHNYNVNSDLAYDTARLVFLDTLGCGLEALKFKECSKLLGPVVDGTVVPNGTRVPGTPYQLDPVNGAFNIGAMIRWLDYNDCWLAAEWGHPSDNLGGILAVADWVSRTNRAGGNIAGGKIFQVKDVLEAMIKAHEIQGVLALENSFNKVGLDHVVLVKVATTAVVAKMLGLSEKQTADAITQAFVDGQSLRTYRHSPNTMSRKSWAAGDACQRAVNLVLKVQKGEGGLHTVLSAPIWGFYDVLFKGNKFQFQRPYGSYVMENVLFKVSYPAEFHSQTAIEAAQIVNVKLKALGKTAADIKEIRNRTHEACIRIIDKQFKPMDNFADRDHCVQYMVATMLAFNRLTANDYADGSEAATSQLLDDLRKRIYCVEDPQFTKDYHDPAKRTIPNALTVTLNDGTVLDEVVVEAPLGHRLRREEAKPEILAKYKRHLEAHFDQARIDQLIQIGWDRAALEGYDVDQYVDLYVKDQIVASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRW5</accession>
    <name>A0A8G1VRW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_387894</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521436.1">
        <property type="nucleotide sequence ID" value="XM_025656689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRW5"/>
    <dbReference type="GeneID" id="37160091"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH63514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="683" mass="76910" checksum="FD6615D3499C1E6F" modified="2022-01-19" version="1">MSPRMRDHHLSGRTRHFTQSAAGSRGREALRSRTGCPECRRRKTKCDEQKPECGQCLRAGRACRIIDGLFRPHSYSFLVSSSSSSSQRVHHASCLEGYSPEEDGLQNGAQISQQTTEPVVQVPSYRGQRARTDSPNSRHFQGEPGQECSVGIAVGAQHARTPFEAENFMVGVSPPGTPEPLAEPGPQAITRAHIQNERNAAIVAPAAHGFSGLPNSTHEDNRRDRCEVAFFLRHFSEGPGQWMDVCCDHPYFSEQVASLSPVCSLIRYSAVALAAKQLGYMKQPESSIRQTRSHRFMMHAFADSHLDFLWYGAKYYDKAIQIFSKQLSREDRSICQLSPRGGYQAGLPTPESSEFRLAGDYDRTGSTLQILAACILCQYEDLSATMAAWSSHLDGIYRLIHGYLNETATPPTAFHIPQPMKTMDAMYWFFSINDVLDAFVNKRRTRLGSKNPLMWRKMGLPLDEDGKLLVQYVEEVHSESVFFKYLIWLMCKLVNSDLGNTVEWNAINKQFGEWRAILPSIFSSAISWPPFSEIDDAQDPATVNLSSHETWFPKDACALSMAFYHMGRILLLIHRPLEVLRQNAQPGTDILSTYHTLQHDLRGHAMAIISIARGAPSGTVRKYLIQPLYVAGRCLEDASEREELLNILRQIDEDLGVFTDYRQRDLALEWGIPYHPVEKNIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VS62</accession>
    <name>A0A8G1VS62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Copper resistance-associated P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_436125</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518395.1">
        <property type="nucleotide sequence ID" value="XM_025658562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VS62"/>
    <dbReference type="GeneID" id="37161964"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000068">
        <property type="entry name" value="Copper resistance-associated P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000043">
        <property type="entry name" value="Copper-transporting ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF32">
        <property type="entry name" value="COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="600"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="769"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="812"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1177"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1223"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="21"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="208"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="294"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="149"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH60473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1273" mass="137736" checksum="793FA90D737B767E" modified="2022-01-19" version="1">MSPSATDTNSRVPAGQDSRLLRSIFFVSNIHCSSCVAYINEVLSDIDGVRDIDVSVLTHEVRVVHSAETDPSRLASALVEAAFEVHHVTTYEPRGSVISELDTTSWLPRDSVLFTTQPNIHRNPALGSRHVDNCDACRKEELDSLAAGEDLADAARRPRDRYSGLRTGGKPGPTQSEVQSLVARGSTEEVTPVEPPKTPHDSEDKERFNARVSIGGMSCASCANSITSEVKELDFVEDIIVNLLTNSATVIFTGPQSNIDKVVEQIEDIGFEASLDEVNMIKKAPARKEAPSKFVAELAIGGMTCGSCSGAVTRGLEELSFVTTVSINLLTHSGRVEFEGRDHIDEIVEKIEDLGYDASVDNVTALVADSDDEPLEERTLSIRVDGMFCHHCPEKVVKSLEAFPDVKVGGNLSVKNPILAVTYTPKPPSLTVRSILRTIESAHDAFTATVYRPPSVEDRSRAMQRHERRRLFTRFIFVLLVAIPTFILGIVFMSLVSSNNKVRKFLEQPMWAGDASRLEWALFIMTTPVMFYGADIFHVRAMKEVYSLWRPGSRAPLLRRFYRFGSMNLLISAGTTVAYVASLAVLIMDAAMGSASNTHSSTYFDTVVFLTMFILAGRFMEAYSKAKTGDAVASLGKLRPTEALLRINASDTDLPGDENRLAEDGYERINIDLLEIGDVVSIPHGASPPADGVVVGTASYQFDESSLTGESKPVHKSAGDQVYTGSVNVGQPVEVKVTAIGGSSMLDQIISVVREGQSRRAPLERVADLLTSHFVPIITLIAILTFIIWLALGLSGTLPDDYLDVARGGWTFWALEFAIAVFVVACPCGLALAAPTALFVGGGLAAKQGILVKGGGEAFQEASRLDAIVFDKTGTLTEGGSLQVSEHEALISDPDVIQVAWTLARKLEESSNHPIARAISTFCKEKPFVTITSADIEEKSGQGMKGTFTVSVPNPNEKSETPTQYQAAIGNQGLLHSLETSDYDESHLSKTLSKYQAAGKSTAILSLRSQNEPSFTPAIVFAISDTIRPDTIEVISKLQKRKVNVYMCTGDNQTTAHAVADMVGIPRSNVMANVMPAGKADFVRQIQDSNNNFTPQTDSEAESQRAPTNNRSIVAFVGDGVNDSPALAAADVSIAMASGSDVAMNSASFILLNSELDTILQLVLLSRRVFNRVKLNFGWALIYNCCLVPVAAGVFYPIVSGHKHEMMGGELVVTDTHWRLSPVWAALAMALSSISVVCSSLALGISRRSIKRVFGLGGVSEALVRCSLYYLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSF9</accession>
    <name>A0A8G1VSF9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="12">3.2.1.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Galacturan 1,4-alpha-galacturonidase C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Poly(1,4-alpha-D-galacturonide)galacturonohydrolase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_238959</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="12"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518680.1">
        <property type="nucleotide sequence ID" value="XM_025654816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSF9"/>
    <dbReference type="GeneID" id="37158218"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000037">
        <property type="entry name" value="Probable exopolygalacturonase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF11">
        <property type="entry name" value="EXOPOLYGALACTURONASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034741629" description="galacturonan 1,4-alpha-galacturonidase" evidence="17">
        <location>
            <begin position="20"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH60758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="443" mass="48039" checksum="7554198FAB868EB6" modified="2022-01-19" version="1">MSVFKASLLFLLSSSLVHGVPHSSRASRSQQCVVPSKYQASNGTADDSSAVSQAFAECATDSVIIFEEGVNYNVFQPITATNLSNVEIRMHGNLHLPQNITAVQNIVSDGSSTWFTLEGPKVDWTGPEDVNNGWIDSYGQPWWDANPAGSSGIDNRPHLMSFKTSQATIKYFRSRKPIAWNVKLHGQDITVSHAIIDATSTGSFPFNTDGFDVEGTNIQITDSIMYNGDDAIAVGADSHDILFTRNTIGYQTHGMSIGSLGKDPTDFANISNIRFDDVTVVDGLYAARFKSWSGGTGLVKNVTWNNIRVFNVTFPIYVTQSYSDQGASRSGTVNASSAVMMEDFTWSDFSGSINTYQPGDGSCVSDPCWYNVGLPNLKHTEALIIECHTGQSCKNFVTENIQLYPQVLEPASVICMNATAALNPDLGFTCKNGTYSPISTGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSK4</accession>
    <name>A0A8G1VSK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_444364</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a stable heterodimer with SPT16. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the SSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520944.1">
        <property type="nucleotide sequence ID" value="XM_025659000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSK4"/>
    <dbReference type="GeneID" id="37162402"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.220:FF:000003">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000146">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000310">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="14">
        <location>
            <begin position="380"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="487"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH63022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="576" mass="64103" checksum="878DE4FDA55C7BA2" modified="2022-01-19" version="1">MESFDNIYLDLSKQHGKCKLAESGLGWKPSGGGETFTLDSSNIGAAQWSRAAKGYELKILSRSSGVIQLDGFDQEDFERLSKAFKIWYGINMESREHALRGWNWGKAEFTKAELSFNVQNRPAFEIPYSEISNTNLAGKNEVAVEFALGGEGNEPAKPAGSTKNRGRKAASGPDELVEMRFYIPGTAVKTEKGIKEENAENPDEENGAEEEEGEEQNAANLFYEMLMDKAEIGDVAGDTFATFLDVLHLTPRGRFDIDMYESSFRLRGKTYDYKIQYASIKKFFLLPKNDDTHTLIVLGLDPPLRQGQTRYPFLVMQLKLDEEISLELNMTDELLETRYKDKLEPRYEEPIHQVVTKIFRGLSGKKVIMPSKDFVSHHGHSGVKCSIKANEGLLYFLDKSLIFVPKPATYIQIENIAIITMSRVGGAISASRTFDITVSLKAGLGEHQFSNINREEQQPLEEFFKAKNIRFKNEMSDDASALIAAALDNDDMGSSDDEGVRADRGSADEDEESIDEDFQAESDSDVAEEYDSAHESSGSASDAEMGDASDGEDDDEDEPMSEAEGARPKKKTKVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VT53</accession>
    <name>A0A8G1VT53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aryl-alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_415006</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519385.1">
        <property type="nucleotide sequence ID" value="XM_025657668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VT53"/>
    <dbReference type="GeneID" id="37161070"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF210">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="24"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH61463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="617" mass="67028" checksum="F5992F76F6496388" modified="2022-01-19" version="1">MKRDTTSLSDIPPVYDYVVVGGGTSGLLVASRLTEDPAVSVLVLEAGSDRVDDPRIAAPALAASTYFDPEFDWSLISEPQEGLNGRRLAQSRGRTLGGSSAINMGMAIYPSRSDIDSWEQLGNSGWNWKSLSTYMRKSQTFIPPSDEIRDQLSLGYVDPDVQGTDGPIQISFGNGPFPAFTAAWPRTFEALNHRLTGDPMSGLAKGAFCNPATIHGTSRARSHAGVAYYTPEIAQRSNLRVITEAFVEKVLLDKTACVDDGQAIATGIQFRGNDGTQRTVAARSEVILAAGTIKTPHLLELSGIGDAKLLQAHGIDITIDNPNVGENLQEHGLVPFTWEAADGQITGEALRDPEVAKAAMEAWQSSGAGPLGSHPLGSAFMTLPELENGELSGLIEKHLKEDGCARQTAQYRILRRFLEDDDEPTCQYTLAPFQMTPDKGSDPRGTFSMSEPGNYISIVAVLNRPFSRGSVHLASSDPTVLPTFDPRMLSHPLDLEIQARHVMWLETLAATEPMASLLKPNGRRLHYPTRVTSLETARELTRDRLLCHYHVSGTAAMMPREIGGVVDDRLRVYGCRNLRVVDASVIPLIPRGNIQTTVYAVAEKAADIIKEDRLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VU19</accession>
    <name>A0A8G1VU19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_413603</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520330.1">
        <property type="nucleotide sequence ID" value="XM_025657614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VU19"/>
    <dbReference type="GeneID" id="37161016"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040750">
        <property type="entry name" value="eIF3m_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18005">
        <property type="entry name" value="eIF3m_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="190"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="424"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH62408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="473" mass="51233" checksum="EA5A6991E9F5646C" modified="2022-01-19" version="1">MPAPSTTLLIEGSFTELADEFAQYIDALRKSEASSSLQSEISPLLQPLREQEQSEAEPDRKQRDEVLKKLVSAAVVLNSAPEKEIISAYNLLVHLVHQASDPDMFLSRICTYLAKPISSSPQFGPSLAISILSTIFNTLAPSDSSRYHVLLATVAVIRQSSSSIAFDALKSQLVAQLPSWLAAWELDADEAQRLHLAIADAAQASGDPELAQTHVVQALQTIPAANASAPEARDLAVRALTSALTHPAVFDFTPLTASDAVQALRSSDSTLFELLEIFTADTLDAYEAFISATPLASISGGVLAEAGEALQNKMRLLTLASLAASTPSRSLPYATIATALRVEPTDVEKWVIDTIRAGLVEGKLSQLRSEFLVHRATYRVFGEKQWAEVQGRLMVWRRSLENVLGVVRSERERFVREGLQAAQAAEEAAQGKGNDKKGGDRRRHNNNNQQQQQQQQQQAPAAPAAAPEAVAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VUW6</accession>
    <name>A0A8G1VUW6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_444564</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521185.1">
        <property type="nucleotide sequence ID" value="XM_025659042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VUW6"/>
    <dbReference type="GeneID" id="37162444"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF40">
        <property type="entry name" value="TETRACYCLINE-EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="80"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH63263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="588" mass="63659" checksum="61938E7BBF90E557" modified="2022-01-19" version="1">MSTIRRGASPTAHTEVGPGLQAGLDASAPIDTGLENERTPLLEQDNEESLPEHDHRADPSNDDPVGQGGFWQTWRRPSILWILPFLVFYMLGIGGTAVPKINLMMSLICRDYMANKATQDPGFTYLPVIIGNKNSQCQTPEVQSLLAQFQLYFNLLAGILSALACPRLGHLSDRYGRTKILALNALGTILAEAIFVFVSAKPDLVSVHVLLLAAIVDGVCGSFTTIMALTMSYASDCTIPSKRSAAFGYVYGSLFAGTAAGPLLAAILIKKTGQALSTFEASLALNVLYLIAVMTIIPESLSTDQQRQARDSHRRKVIDEGEAGWLSLENLNPKRLITPLAVLLPPVGRPSTLFPNRHGATPALRRNIILLTAMDTIAFGVALGTAQVIIIYAEYKFDWGNVESSLFISIISIARVVNLFVVYPIIIAIFREPQKPDHIVPGASTCEIVLIRLSLFLDMIGYVGFAMSYHGSIMVFSGIVMALGGMGIPTMQSSLTKHVPRERLGQILGTKGLLHALARVISPTACSLLYSLTVGKFTPAVFVVLGGLFFLTFCTSFFIKPHVTLDDSYPSSPRDEANDEGFVADSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRP7</accession>
    <name>A0A8G1QRP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_524456</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">PML body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825085">
        <property type="protein sequence ID" value="RAH52398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510320.1">
        <property type="nucleotide sequence ID" value="XM_025665416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRP7"/>
    <dbReference type="GeneID" id="37168818"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070260">
        <property type="term" value="F:5'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09080">
        <property type="entry name" value="TDP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051547">
        <property type="entry name" value="TDP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822">
        <property type="entry name" value="TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="11">
        <location>
            <begin position="69"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH52398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="333" mass="36583" checksum="B71606F0BF75D503" modified="2022-01-19" version="1">MTPSANVSTQFPTLPADADAPPIFQEWYSFDALSDCWSSLPPSTSVTCDESTMSASDKAKLKIPALNLVTWNVDAFAKFPDDRMAGIISTIRNQTPPPNILFFQEVPKAALFYLLNEPWIRENWYSNEGDSSNYGGLAFITVILLSKASFSTDSQDPDKACLGPVWRVDYPSKFDRDALCCDVFMPQSATRVRLVNVHLDSLAFQPSCRPRQLAIVANSLRCAGHGFVAGDFNPVLPEDDSLVATNGLVDVWNELHPDEPGFTWGLDGREPFPPGRLDKVAVLGLKGQEMDILHPGAINSAGQGLQLRQLDSPMPWSDHSGLKCSLRLAEEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRQ4</accession>
    <name>A0A8G1QRQ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Phosphate:H+ symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_463348</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511018.1">
        <property type="nucleotide sequence ID" value="XM_025661918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRQ4"/>
    <dbReference type="GeneID" id="37165320"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562">
        <property type="entry name" value="NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562:SF3">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="202"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="684"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="709"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="864"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="897"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="930"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="961"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1037"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="608"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH53096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1091" mass="117539" checksum="3A2A2F2E09804D3D" modified="2022-01-19" version="1">MASSGSDAAFAYHEPSISTLLNQAGLLVVLNLINVCLDKLLYCGLIGQLFVGILWGTPGAKWLDTETERVIQQLGYIGLIMLVYEGGLSTSIKSMRANLVISLCVAHTGIGVPMGLSFILGKLVSASPLQAFAAGASLSATSLGTTFTILSTTNLIPTRLGTVTTSAAMLDDVVGLVMVQIISNLGGGTSSFNAVTVVRPLFVSIGFGLGVFILCAFCLKPILQKALTMRDNMPQFMGSMQFAFLAQTSVLVGLVAGATYAGTSSLFAAYLAGVIISWFDGLAADSYIPNANTDRNTSQSGSGVLVERTTSEQSTPQDLPDSNTPSTPQEPSYNPHEKVPTGIEVYEKYYKEPVNRILIPLFFASIGFAIPITEMFRGDVVWRGIIYAILMMFGKMVTGLWLVRFSLPSTTTLLFTLGRPFSWALFSCTSRKGENKKKKKSKEKDTRPRRQSAVRTEQSDQNADARNSDEHKGNPPNPNRNEPVSETEPQTTSSNPSSTMSLPPKPKSLYPPFILGLAMVARGEVGYLIASLAESQGMFSGGSNGDVSEIYLDIPLVTPSWDNMAAPDTAAFPNYNVDLSHVEDPNERRRLALARIDDAPFGWRHARAVVVAGVGFFTDSYDIFAINLCSSMLGVVFWEHATNRPGKIPYSSDTAIKVSTSAGTVVGQLFFGWLADIVGRKRMYGIELIIIILATLAQCLSSNSPAVSITGLLVFWRTVMGIGIGGDYPLSSIITSEFATTKHRGAMMGAVFAMQGFGQFAAAIVALIVTVGFKGSLESAASVSKCSGVCQLAVDKIDLLKADEDVDAYIWGKHEGHPDEVKRVAVLQSADIRLVTPKSSWSDFRSHFTTWKHGKVLLGTAGSWFFLDVAFYGLGLNNSIILTAIGWNGGSTVYEYFYRNAVGNLILICAGAIPGYWVTVATVDRLGRKPIQITGFVILTIIFIIIGFAYEPLKRSNNGLLALYVVAQFFFNFGPNATTFIVPGECFPTRYRSTSHGISAASGKVGAIIAQCVFGPLAHRGAKGGVNSSDTPWLNHVMQIFALFMLCGCLTSLLIPETKRLTLEYLSGEEPTPTPRVTASEQEQGPKRDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSX3</accession>
    <name>A0A8G1QSX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sialidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_454646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825097">
        <property type="protein sequence ID" value="RAH51675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509597.1">
        <property type="nucleotide sequence ID" value="XM_025661335.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="37164737"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
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        <location>
            <begin position="626"/>
            <end position="650"/>
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            <begin position="30"/>
            <end position="44"/>
        </location>
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            <begin position="83"/>
            <end position="98"/>
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        </location>
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            <end position="168"/>
        </location>
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            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH51675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="71468" checksum="6577C056C4DB502D" modified="2022-01-19" version="1">MSVEYSYYRPSTPPALHLQEYSGTGHSRNASDSSVYSNNSSPWSVITSATSPVVDSPPQHHHGPTLLPKIRPQDIVIEPPPASGSQRQRRVLSNTRNPPGSLPLASNRRSSHRVAVETSGCIPMASPAVASPKYTTRNGSSLSSPVSVTPAQKRKATSAHTRSVSASNVEDPRTSRCGYPAYRQVIRYASQPQSSPTTPATPATPNIIVYPPYAPHSPAEPYYPKVYPPVQVPLMLPGSPYGYVRASSAQCSPIGIVHQTERTNSQSTTLLSYLTTPTQAINLVRNVNVIPTRGLHDYFWWDIRNLRSWTSFSLSTFNSISGLPKLLKTAIPSHLTPLNILPSSYLSPDCESALVNVIRDIYAPRINAALAVSQGPDHLSLYAVPIPRGSPNKNYGGPHFLANYASDTERTASGLARGRLVGIVKTFDRWNTGMRNEAPHRRVEYLNGLAHLQRCMREHSCRYGFILTEIELVCVRAGCDEGDDVPYFGFLELSAPIPTKLAINQRGHSSEPYTSDYGYPHSPTPSSDSSLASQSPILDSYTISDSDELDVPMTASLALYFLLMLSKSVPLPSQPSAHLNVGGPGALTRQRILPEKKDKWIPEPQIGERRDAKRVRGWVWPQDAWHRREGGGAPRSRAMTTEPRPKKWHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSY1</accession>
    <name>A0A8G1QSY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">14-3-3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_206869</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510164.1">
        <property type="nucleotide sequence ID" value="XM_025654578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSY1"/>
    <dbReference type="GeneID" id="37157980"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="5"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH52242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="272" mass="30738" checksum="F27FA5356571BBE2" modified="2022-01-19" version="1">MYSYRENKTFLARLCEQAERYDEMVTYMKEVANIGGELSVDERNLLSVAYKNVVGTRRASWRIISSIEQKEESKGSEQHVSIIRDYRQKIETELEKVCQDVLDVLDESLIPKAETGESKVFYYKMKGDYHRYLAEFASGNKRKVAATAAHEAYKNATDVAQTDLTPTHPIRLGLALNFSVFYYEILNSPDRACHLAKQAFDDAIAELDSLSEESYRDSTLIMQLLRDNLTLWTSSDGNDAEGAAPKEDKPEEETAAAPEDKAEEPKPAAPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT80</accession>
    <name>A0A8G1QT80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_523782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511145.1">
        <property type="nucleotide sequence ID" value="XM_025665380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT80"/>
    <dbReference type="GeneID" id="37168782"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="7">
        <location>
            <begin position="69"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH53223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="520" mass="59388" checksum="02D0824E37A595C4" modified="2022-01-19" version="1">MTLYYNATPASRTTSQTDWNNHDEFFKFTRGRFLVDEAINRRMREIQFDMNSLARVAAESVGATHCTSIQKYPDGMFNKAFLMSMDNGREVVAKVPNPNAGIPHLTTASEVATMDFARNVLETPVPRVYTWNSHAQSHPVGAEFIILEKAAGVPLSHVWETLKLPRKLQVLLAVIRLQKKWLSVLFSHYGSLYYAKDIQVSPPEDTHYIKNGKAVKDSQFAIGPTTGRDWCDASRSLLDIDRGPWSDILQFLQAPYSAAQTKLTALSHYLQILESLIPKDTALTNPHLWHNDLHDDNIFIDPQNPESITSIIDWQSTHVSPLFNHNPDPAFLDWTDGLEPETLDLLPRPNLSGLTPQERAAAVREYTTQNLFIGWRKLTRAKNPALYRAIEFRKTPAYRLIFLAHRMFEYGEAHFMSLLVDMKDHWGDLPDTGDVPFPFEFTDAEIERIKVACDGAVAGTELVDGVKEQLGGLWPDKGLIENERYEECRAALGEVRDRIVEELGESEEEREEYRRWWPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTA9</accession>
    <name>A0A8G1QTA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Exosome complex exonuclease Rrp6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_453363</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511190.1">
        <property type="nucleotide sequence ID" value="XM_025661034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTA9"/>
    <dbReference type="GeneID" id="37164436"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000059">
        <property type="entry name" value="Exosome complex exonuclease Rrp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.80:FF:000001">
        <property type="entry name" value="Putative exosome component 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="HRDC" evidence="10">
        <location>
            <begin position="450"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="617"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="622"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="740"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH53268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="784" mass="87307" checksum="B67E122E4BD7D2B4" modified="2022-01-19" version="1">MDSTADFGSLQQQVQSSLMQVTRTAGQLSAEDLDFHRTSNAEVSDSLDEQSNRLLSLTSSILKAATAGTDISAPTLDDEDSLEDNWRGVVDVIDALLEKADACLDEFTGVIKKLSPSQQDQAAAAAAKAAKKQPAKFPTIYDYGPSKIPKPQLLFERKADNTDTAPFKPLLKTKPHAVVPLKDSLKLSGSAVGYVNPYETEIRAAKYPASSYSVSPPVDYQPWESTKATFVDTQEGVKEMLEELKAAKEIAIDLEHHDVHSYQGLVSLMQISTRDKDWVVDTLKPWREELQVLNEVFTDPNILKVLHGSSMDIIWLQRDLGLYVVGMFDTYHAACALNYPKRSLKFLLQKFVNFEADKRYQMADWRIRPIPEGMFDYARSDTHYLLHIYDHIRNELVENSLPDNNLVDYVLEQSKKEALQVYERPVYDAATGQGPGGWYDLLSRNSVVVNREQFAVFKAVHQWRDEVAREEDEGVQCVFPKHVLFRVAHTMPLDLGTLFRTLSPVTPIVQNRAVDLLEVIKKAKDEGAEGPEWRDVYVKPTRGTPATPATQAVDVSSPSPAEANLPTVSRYEVSQFWGSVLESQEPPTVPEYSAVASAEALRLSLPLPPMPRTVSEAREKLAPAQPQTPKPATSAPAVKEEKKEEDENKYFTVKEMGGPRKRKAAPAETVEQLQSASSEIDGPTTDASSSLDIEDKPSKKQRRKEKKNKVAAQPESASKEDGEEEEEEAAFNYESAASVFNANPKATSGLPSRRRYNPYAKVLDAPSGVRKQKRETAGKAFTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUC7</accession>
    <name>A0A8G1QUC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_509998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825097">
        <property type="protein sequence ID" value="RAH51655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509577.1">
        <property type="nucleotide sequence ID" value="XM_025664523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUC7"/>
    <dbReference type="GeneID" id="37167925"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH51655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="87" mass="10652" checksum="F97892644158A641" modified="2022-01-19" version="1" fragment="single">MWRNHQIHQFSFWCRFWLSHRPSTSEGIPHPRNFLFARLPRVLFSSFNLFPPSYQFFLNRVFFWVPFFLSWVRGRVVFDSIALVLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUD7</accession>
    <name>A0A8G1QUD7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_104727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512443.1">
        <property type="nucleotide sequence ID" value="XM_025653806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUD7"/>
    <dbReference type="GeneID" id="37157208"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="122" mass="14178" checksum="BAB27F40D806E0A3" modified="2022-01-19" version="1">MAPGEYYSLRHIPELVKLASIQPATQADCIPTTLSGPIPAVSQRLEGRLSLRTWDWEIRHTLKCRGLEHLLRSDLPRPDKANDRFALWRHWSITVRRWMNRQLSRKIRAKLGASRCAKKLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUT7</accession>
    <name>A0A8G1QUT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_382546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510931.1">
        <property type="nucleotide sequence ID" value="XM_025656470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUT7"/>
    <dbReference type="GeneID" id="37159872"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046486">
        <property type="entry name" value="DUF6579"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20219">
        <property type="entry name" value="DUF6579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="404" mass="45030" checksum="8FBBD8F983FDB392" modified="2022-01-19" version="1">MVFKSLPNLLTTLTTISKTTHDLLSTILIAQDSHGDNPLYASTALTLASSFAPPALAAITIHQALETNTQLRQISSHLGTISDTLARDNALRVASEFPTLVYNMLQHKIKSEPSSIWYLVYHPDTIWRHHFEDLVLNRGVLGERFIGIFGSLDAVVIYMQAMRRAGVGRGGGEGEVHFRLLVPAYYPITVETPIKFPVESIEPFDVYCDVHNGVPLVRMFLPGVREGELGNVGLWKPQRGFWEQLFGIGTGQDENPRLLGMQVLHDGEIGKTDGLVIHDQSVDEPIRQPGEQVQVQEKMRDVLAEDPVSGDEYIYEEAVGRETDDELERASTVASAGETEQHTIRHHSRRHKSRHSTASQAGSVAGSDFYSVYSWTSGQSSRSSGRRHKRRHDSRNGSDRSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUZ5</accession>
    <name>A0A8G1QUZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Plasma membrane protein Pth11-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_522990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512060.1">
        <property type="nucleotide sequence ID" value="XM_025665307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUZ5"/>
    <dbReference type="GeneID" id="37168709"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH54138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="351" mass="39113" checksum="3720A395B541B858" modified="2022-01-19" version="1">MAVSPLDVPNKGPEFVKVTAVLTCIAFVLVVCRLTWKGYVQGRFAVDDGIIAFSMAMQIVNTVMGDLACHYAFGRHKADIVRTGGNVVLALKYFWLFQIFYKLVLCLNKLSFLTFYLRVFPNRIFRTICWITIGLVLASTFGFVIATIFQCTPVRASWYKHIPKKCVQNAPFRWSWAGYNTAMDIWVCLLPLPVLAQLQLDRIRKIGVMLVFCMGLFVCVTSIIRMWAMEKSTTTTDPTWGSFDALLWSAIEASTGIICACLPFLKHPIQKVLPGLFGSLSNGSRKSRSRTRPSYRMSRLGSRSGNGTRNVDADICGDEDDSESVGSQGPIAKNQIIVKTGISMHSEAAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUZ7</accession>
    <name>A0A8G1QUZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid adenylation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_383310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510617.1">
        <property type="nucleotide sequence ID" value="XM_025656514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUZ7"/>
    <dbReference type="GeneID" id="37159916"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="70"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="481" mass="51193" checksum="B7D2846E771EFC89" modified="2022-01-19" version="1" fragment="single">VVLEHWAQRISSSLASHLADTFTAAILAILESPKLDLRLIDLTGPTSLSQIHRWNARPYPINDVCIHHAFEAQARRYPNAEAVCSFDGALSYAELDTLASNLAGELIAHGVTRGVLVPFILSKSYRAVVGILAILKAGGAGVPLDSRAPHHRLQTIVSDTKARVILCSSEFQHSASAIVSAVVVVDAVLAVREHLRSHQLQDPSRPSDPAFVIFTSGSTGTPKGSILEHGSLSTSALPLQPVLNMHSGSRVLHFASYTFDVSIEEVCFTLMHGACICVVSEAERMDDLGSAMRRLGVTWAELTPTVAAMISPGDVPCLQTLVVGGEIPSQSVITSWALKVQLINTYGPSECSVTCTATDPLTPKAHGAHVGFPVGCRAWIVNLQTSSGLVPVGAVGELVVEGRIVARGYLNNPALSKARFLSSAPWLPDDAAGPSSLYLTGDLVRYSDDGSLTFVGRRDGQAKLHGQRLEGPCCIFGSAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVG2</accession>
    <name>A0A8G1QVG2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-transferase family III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_524566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510087.1">
        <property type="nucleotide sequence ID" value="XM_025665423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVG2"/>
    <dbReference type="GeneID" id="37168825"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF1">
        <property type="entry name" value="ALPHA METHYLACYL-COA RACEMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="577" mass="63438" checksum="5A9F800CE676F6EE" modified="2022-01-19" version="1">MTLAHETVPGTEVYGPGTFIDKTVLPVPVDARRVFELLASRTPGFTQNKVLWDTAHFEGRPEPMVQGPIKSPVMAAALHAMGGVVANELLELRDGNPATDNSVTINTDHAGIWLGSVFTTYINGSDVSALARSGKLSSLFERNYEQGFGKGIASRATAIYQTKDPKVWYQLHGSLDANAALRTMGINPDVTFSTPQQYYDYIQGHIIKWSPDELEMHNVRHGLCGSICYSPEGWRKTEFGKRLSRHPLVNVTAETYAKPTPPIPLVKGLSDKRPLAGIKVLEMVRIIAGPQIGVTLASYGADVIRVNCSRLVDLNALQLTLNAGKRTIDLDITKPEDMERLQELLADVDIFIQGFRMGSLERKGLGLRNMLEIAAKRNKGIIYVDENCYGPDGPFHERPGWQQIGDAASGSEYVMGRSQGYEEGKSVLPPLPVSDMITGIVGAVGAMIAVKRRAVEGGSYHITSSLVAADAVALEKEVGLYPPEVVRDTVERFGFKGITPDQYVSEVLIPVIDGWKRGLPHDLDEDSRFMTTFKEPGPWGRQTLLKPVAKLGLEESTPRWTSPPVPHCHHGRHINWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVG6</accession>
    <name>A0A8G1QVG6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8213 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_504607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511276.1">
        <property type="nucleotide sequence ID" value="XM_025664306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVG6"/>
    <dbReference type="GeneID" id="37167708"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058526">
        <property type="entry name" value="DUF8213"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26641">
        <property type="entry name" value="DUF8213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034575416" description="DUF8213 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8213" evidence="2">
        <location>
            <begin position="28"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="153" mass="15669" checksum="A8A4EBE8887ECBD3" modified="2022-01-19" version="1">MISLSTLLLTLSLTLTATAHPSVTHQKRSVTCLKVGATATASWTNSADQTCTYVGVVGSNYGENSDGDGDYSCNGRCGTGCSGIALGNVYTQDCFSHDICSYFEDASGGASDPNCGAAFKAAEDDYLLGLVDGCSQTNPTNAVVKPTATPVCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVM7</accession>
    <name>A0A8G1QVM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_500465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512405.1">
        <property type="nucleotide sequence ID" value="XM_025664123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVM7"/>
    <dbReference type="GeneID" id="37167525"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06587">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="11"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="176" mass="19774" checksum="B642B027EF8ECEA8" modified="2022-01-19" version="1">MAPSIATAPGGLNHYAYATNDMVKTHKFWTEVMRCKFLGAQRQGGEPDKYSGETLGSFLHCFYGLADGSAVAFFELANNFTKTDDGIPAFTKHLALSVNSRDELYDWMAHFKSCGVDVKGEIDHDGLWYSIYVIDPNGQMVELTWQSRAFNDKDVEEGLEIMRQWREDKAGGRLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVM8</accession>
    <name>A0A8G1QVM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_522604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512610.1">
        <property type="nucleotide sequence ID" value="XM_025665277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVM8"/>
    <dbReference type="GeneID" id="37168679"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034024286" description="Concanavalin A-like lectin/glucanase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="23470" checksum="0DFE16213E307706" modified="2022-01-19" version="1">MRGIEALAFLAAIGAAHGQSTVGFGPYFSLGPTQSWIREANTTLVLPEAPSPQKDRLALWPGMGTSGGDLIQALAVSFSDPNSNCGASSGQWCTWASTLEGTQLGGKEVPASAGDKVTMHYKYNDSTGKYDQTVSINGEVVSTLSTSSGQAQGWGTAVECQDDACQSTAGAHKYLDTTIILNAEDNSFGDTLSINEASSSGLSTSDNGKTWTVSTININSHTYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVT0</accession>
    <name>A0A8G1QVT0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-serine dehydratase</fullName>
            <ecNumber evidence="11">4.3.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-serine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_430344</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conversion of D-serine to pyruvate and ammonia. May play a role in D-serine detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13978"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSD1 family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.18" evidence="11"/>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511037.1">
        <property type="nucleotide sequence ID" value="XM_025658287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVT0"/>
    <dbReference type="GeneID" id="37161689"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000016">
        <property type="entry name" value="D-serine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0216">Detoxification</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="14">
        <location>
            <begin position="328"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH53115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="455" mass="49455" checksum="00AD6055EE1F379D" modified="2022-01-19" version="1">MDFPTRPPPSQESLQRYYIGKDIGSVPKPAVVLDVAIIKRHCASMLDAVKTLDVGFRAHVKTHKTPQVARLQVGEDKSIPANFVISTLLEGETLLPLFKELRATGRKVNVLYGIPLVPSQVPRLAALARELGEGSISVMIDHPDQVPYLTEFRELAGHAASVFLKVDSGYHRAGLPPSMLNKGGLIEKVIEGEREGKLALLGVYSHNSLSYGGDTPEKVMGFLVQEITGCREALRKNKDLFTLPGGKGRELVVSVGATPQVVVVKKLLEEEGQLTEEARRLKSLLHEKNVDGELSVKVELHAGVYPVLDMQQLGTNIHPTADADKEVGISVVAEVCSVYNDAERSKPEALVAAGSLALGREPCKSYPGWGVVGDWRREKGSSRLIVDRISQEHAIVAWEGGDGSAIPLKVGQTVRIYPNHACVTGAMYGWYLVVDSSRDGDGSTIVDVWPRLTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QW56</accession>
    <name>A0A8G1QW56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_88625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512895.1">
        <property type="nucleotide sequence ID" value="XM_025665757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QW56"/>
    <dbReference type="GeneID" id="37169159"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF127">
        <property type="entry name" value="HISTIDINE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034738495" evidence="4">
        <location>
            <begin position="23"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH54973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="525" mass="56456" checksum="71F1CC53315F76C1" modified="2022-01-19" version="1">MLSTRQFVALAAILQAATQASAQDLKEQVWAVFAYTLYGDRVPTALPRPNILTPYGANTLYEAGSAFRDRYVAIHSTDVSPSTRIESISTYALEDEDLDILSTTDPSVIASAQAFMQGLYPPLNDTYDVQYPDPSYLMANGSFATAPMGGYQYPPIVTVSSDDPQSVVVAGQDNCFLHQIANADYQASTDAQQMIQESDALYNRLYIQALSGDFDRSSVNYANSIAVSEFLEYQLLHNETLLHSVSQEDIRLARWYADQYTFATNGNSDTSLSSPIDSSAIRTIAGQTLAGSILDAFDTNVLYRGTSGKLTFVFGGYEPAVALTSLVQLASPANGKFYGRPALGASLTFELFSLENQSFPTYPDPSQLYVRFLLRNGTTSPEFQSYPLFGHSPSSIEVPYSEFKAEMQTFALNSTQEWCLQCDSSSSAVFCPGVLDDGNDGPSSSAASSSGRKGISPAVGGVIGAIVTLVVVGLIAAAGFLLLGVRVQRGRRPSLEEIKGGIDLGSDSNLALREHAAPPAKTARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWA8</accession>
    <name>A0A8G1QWA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="2">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_452954</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="2"/>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511711.1">
        <property type="nucleotide sequence ID" value="XM_025660954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWA8"/>
    <dbReference type="GeneID" id="37164356"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="12">
        <location>
            <begin position="53"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="10">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH53789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="357" mass="40023" checksum="2F55AE58A5D0234A" modified="2022-01-19" version="1">MATATAAANATGPQTLKDPIVSIKPTSATRPPTTRTTYTLNTGAKIPALGIGTFQDPDSQEDTVCQVLQHGMRLIDTARVYGVEKQVGRGIKKSGVPREEIFLGTKLWCNDFHPDDVERAVDDSLRDLDTPYVDLLLMHYPCTFKRGEDRFPRDAEGRMIHGDTTFVDTWRALEKVVETGKVKAIGVSNFSKGEIETLLRETSTVPAVHQMEVHPYLQQKGFNEWLREKGIHVVQFSPLGNMNDFYRQAGWSKEIAHMMRVIDQPILKAIGQKYGKSPVQVVLAWGINSGRSVIPKTVIDWQIEENLAADFELDAEDMAQIATLDAKARFNDPSYDYEWRLYSDLEGIDGTVKGRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWC3</accession>
    <name>A0A8G1QWC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_451984</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513000.1">
        <property type="nucleotide sequence ID" value="XM_025660717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWC3"/>
    <dbReference type="GeneID" id="37164119"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000006">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000052">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="297"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH55078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="600" mass="67667" checksum="5BDFAE787BF575E4" modified="2022-01-19" version="1">MPTISVDKEALFKALGRDYTTEEFDELCFEFGIELDEDTTNSDRPIVNGKQEPPQLKIEIPANRYDLLCFEGIALMLNIFLGRQPLPNYKLVEPANGELQTIIVKEDTMKIRPLVSGAILRNIKFDQARYESFIALQDKLHQNLARQRTLVSIGTHDLDTIQGPFTYEALPPKDIKFVPLNQTKEMNGEELMAFYEKDKHLGKYLHIIRDSPVYPVIYDSKRTVCSLPPIINGDHSKITLDTKNVFIEITALDKTKVEIVNRIIVSMFSQYTSEPFTIEPVKVISDHNNETRVVPDIAPRTTQAEVSYLNQCCGLELSPEEICTLLKKMAYDAKPSTASKDLIDVFIPPTRADVLHQADIMEDVAIAYGFNNLPRSFPSKSGTIAQPLPINKLTDIVRMEAAMAGWSEVLPLILCSHDENFAWLNRKDDGNTAVKLANPKTTEFQVVRTSLLPGLLKTIRENKHHAVPMKVFEVSDVAFKDLSLERKSRNERHFAAAWYGKTSGFEVVHGLLDRVMAMLKSAFITGEEGLENSAMADSQYWIEELDEPTYFPGHAASVHVRIAGKEHVIGAFGILHPTVLENYELKYPVSTLEINVEAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWL7</accession>
    <name>A0A8G1QWL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_403686</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512268.1">
        <property type="nucleotide sequence ID" value="XM_025657238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWL7"/>
    <dbReference type="GeneID" id="37160640"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF23">
        <property type="entry name" value="3-PHYTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034212231" description="3-phytase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="70"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="440"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH54346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="501" mass="54992" checksum="A579C253F470548B" modified="2022-01-19" version="1">MVRFLMHSVISSWLLVVVSGSNAQALAPTNDILFPSTPTTQNPLQYAGGNSPYFAGPNVFGIDSRVPDKCSVQQAAYVVRHGSRFPDSGSYESWVGIKEKIQAAVNSTGFEARGSLAFIPEWTPVLTNPSLQMSQESMTGWKEATDLGYQLRARYPHFYEDGTPFYAWANAYQYPLNESRVVQTARAFVNGYLYEYADTYGTVVSVNSTGSVSAIGNSLGPSDMCPAFSSISSGGNNVTDFDATWTPKALERINSLVSGNLTFDESDILFFPYMCGYESQITGRLSYWCGVFTEDELRNYAYSQDLSYYYKVGPGSVGPSKVLFLPFLNSLMDLLSKGPGQVGTNADDSNFTVPNLIMAFLNDNQIAEMTAAMGIFDDEPSLPIDQLPAHHLYNIANWITMRGTVAFEVLSCEVESRRRMNDKTYIRVLFNDAVYPIAHCQNGPGRSCLLSDYISLLGEKTKAAGSFDGYCNVTVADAPNPVAGASFFTDLSLDFLTFVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWM6</accession>
    <name>A0A8G1QWM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_102817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512283.1">
        <property type="nucleotide sequence ID" value="XM_025653790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWM6"/>
    <dbReference type="GeneID" id="37157192"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034969866" evidence="1">
        <location>
            <begin position="22"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="185" mass="20135" checksum="60EE235916C06752" modified="2022-01-19" version="1">MKASFTTTVLSGLAAIGSVAANPLRPLGDLVKRNPDGNFTLYAYGLASEPVKLFYADGLAYFGTASDWTYGSVVTDITMTYSSDEVFAEALTEGVTLPDDTLLYIRPNADEVTEVGFTGDDTPSDAVTDKWIWYGGWIMYESDSGELFDTFYVKDTNVSTVWQLFWVPEGVSSSGYTSANVRDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWQ3</accession>
    <name>A0A8G1QWQ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_426652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512996.1">
        <property type="nucleotide sequence ID" value="XM_025658125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWQ3"/>
    <dbReference type="GeneID" id="37161527"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048401">
        <property type="entry name" value="SLS1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048748">
        <property type="entry name" value="SLS1_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048400">
        <property type="entry name" value="SLS1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20777">
        <property type="entry name" value="KH_SLS1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20778">
        <property type="entry name" value="SLS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20776">
        <property type="entry name" value="SLS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1117" mass="127351" checksum="7906E18E64060845" modified="2022-01-19" version="1">MQAFVPKNRRPRFELILRIIDLNNVPLVSGTAFVKWRLPSSSAPEHHGHTDKAIIIDHRAYWNYEKVLQVRLTIDRNQTLHECELYFEVIQEFASGGNSEKNLLGRIRLNLSEYVDKSDDDEGIVRRYLMQDSKINSTLKVGIATRQVEGDRNYITPPLKSAMVFGGIAGVVSSEQGEHDDLGRLPSINTQSREVTDMQDMYRRTLAASWNSRADDLPADKLIEELFSGGISWADGHDARAEKSVENQADRLAPHGRTSVRQASADNRLSPSNFERRPRSSSSNHYRNDVKGTDFAPAADHTRKSGSIEQQLYDNPRGKAWKNRSSEFELSEFDVREDLRSWEVMNKDLLGCRLLPECRASLLPPSLRRHNVSIRFESTETDANHDETPPQHVSSRRTPGHNRLQHHRLKRRLGKKVPISVSSLGNPGEVVVVKDRQRRRLRIAKDEPKEVTDENALPLFLREIDNDDQFVDSELLKTRVESFRLDYEPYHKLPVADWTALRNEFQSSFTYRQLLDYIIEWKENELDRDGTPETTPTRWTPGVSEFLESSYLSRKGVADRVAASQGLKGKFLLAERILRDCWHLGVLDEVGQLDIQLPTHILSLLLSSQHFSFEELANMHDAKIDVTHSLGLVRITGMQRICESISEIVHDAMARVRQESIELPPDETKTRVNNRIYTPEFLSWVTKTYRVAFEQNTPHTPSQIYYLAEDKQDADNARRALHLAYYSGTAPAVPFSTYLPSTEPASVHDIDPENNTSWFERQKPWFRWATPATQSDEVKPSDTVMFDNHQTRVSDELFKLLRQKSSVTHQAHSETGADFHESITAAVGKCLFLRKPFFEESSVNASQLGRMSLPRTFTTDIPRAAQFLRTLARKPVDEHQQAYRFRLVPSALNANVFPQLELEVTAKTSSTPEDATPDFSMRSAKLILSESNVDYLLPENGLDLRFTRKLTRELLPQSQDSNSSSLSNIQESLRSLFSRTSTTDGELPLPPFTQVTLPRDILPQDAADSSAEYIFLPVSDIRGTRIHKYDFRGQQLNYAFYESGPFNPYRTTDLFLNMDMTDGFASADSNVDVSSENVSRDAAASKEEFHTFYNTACALAFELDRARRLGAVWNDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX03</accession>
    <name>A0A8G1QX03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_425707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513110.1">
        <property type="nucleotide sequence ID" value="XM_025658089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX03"/>
    <dbReference type="GeneID" id="37161491"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="43876" checksum="DCA219315E1DF458" modified="2022-01-19" version="1">MFSSEFYHSPGDSFVRHRQLGDSIPRSWRVPSPASAPFVVDLTHSDGGSVPLKSETTPSDTAPASTLPGWLPGTPSPASVYSSPRSEISSISSGEGRSHLSPLPPNQYLGRAPFPSEFISRDLEPADSSSRLAQRSPSQAFSQISQASDSSLLSQSMHPGSVAFLTTNMAHNSQNYGWQNRPPQPLHPTSMPMDQQSYPQAHTLPPQSGYPAAYPPQHATSQSYYQPGLPSTHYLTPQPGVPQSRHQPRSSSIPYPYPSASVSGSPPTMPDPSFTSTPPSYLVNQPDYYLTPNSSLSQTPNSIPQPHNLMPSGTVYSSPESAPSSSDPDQVRVLSFRPKPQCWDHGCNGREFSTFSNLLRHQREKSGVVAKAECPICGAVFTRTTARNIHVAQGKCKGVAREPSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX13</accession>
    <name>A0A8G1QX13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Activator 1 subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_523012</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512086.1">
        <property type="nucleotide sequence ID" value="XM_025665310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX13"/>
    <dbReference type="GeneID" id="37168712"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="76"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH54164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="402" mass="44047" checksum="ED9050C6A281B5F2" modified="2022-01-19" version="1">MSDYKDSMDVDVPSKNAIQFSSDNTNGKAKRVAADLPVEAQDNLPWVEKYRPNTLEDVSGHQDILATINKFVEANRLPHLLLYGPPGTGKTSTILALARRIYGAKNMRQMVLELNASDDRGIDVVREQIKTFASTKQIFSMAPSSSTSASTSSNLASYKLIILDEADAMTATAQMALRRIMEKYTANTRFCIIANYTHKLSPALLSRCTRFRFSPLKEADIRVLVDLVIEKEEVNIQPEAVDSLVRLSKGDMRRALNVLQACFASSIPLPMKNAPKDQDQDQDAKGRPEAEVITNETIYDCIAAPHPSDIEEIMTTLLATSDVTSCLSTINTLKANKGLALADILAALGDQLQRLEVPAQTRVTWLEGLAEIEWRLAGGGSETMQTGGLVGVVRNGCELMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXC3</accession>
    <name>A0A8G1QXC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_442649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511017.1">
        <property type="nucleotide sequence ID" value="XM_025658846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXC3"/>
    <dbReference type="GeneID" id="37162248"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="162" mass="17330" checksum="0CCBB7FD8F36B07D" modified="2022-01-19" version="1">MDESPKCKDKPNQAKPGLIMIRTRTVLRSRSRHEIEGEVDPFRITNHKLQSAVSDLRRTHAPDPYLHSQASKQSFLHPSIHPSFVRSIHIPSLGILIYSVKMQFTLITAFATAFLASFVAANPAPAPAPFEIGIGANAAANAAAEVAANAGLGAGAGIHFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXG4</accession>
    <name>A0A8G1QXG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_440332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513416.1">
        <property type="nucleotide sequence ID" value="XM_025658760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXG4"/>
    <dbReference type="GeneID" id="37162162"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF117">
        <property type="entry name" value="PHO85 CYCLIN PHO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="463" mass="50240" checksum="50F5C200066E6C82" modified="2022-01-19" version="1">METPLSLLDRRHYHDASVHATFTPRSSTRFRSVCQLRCTSFSRAPTWWPRWAEMLVSSPSPSAALRPSPSPSTTTTTTTTTHHSHSHPLPHSQSHPHPSPHSQLSPSSSSYTSYPRQPARQHYEPAGHASAAAASSNSRFDPQSSSRVAIEELRSALNRHTVGSSPPGPSGDIPRGRMSAGLTSSGGGSSTTSHPPADAAIPASNPMRPAQDRPANNVSVPAVSAASVPASGAQSTSTPPMPVPNSAGSGSNKRNSPNDPPVGSERAAGLAHADLEGSQTKRMRPDVPAVKLLPERYELADPRDIVVLISSMLMELIRFNDKIPLNQGRLTRFHSRSPPRISVHDYLQRLTTHATLSPPILLSMVYYIDRLCALYPAFTVSSLTIHRFLIASATVASKGLSDSFWTNKTYARVGGITMTELALLELEFLFRVEWRIVPEPEVLVDYYKSLVERCDGYAIGRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXK3</accession>
    <name>A0A8G1QXK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Family A G protein-coupled receptor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_380219</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH54000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511922.1">
        <property type="nucleotide sequence ID" value="XM_025656370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXK3"/>
    <dbReference type="GeneID" id="37159772"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15028">
        <property type="entry name" value="7tm_Opsin-1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF2">
        <property type="entry name" value="BACTERIORHODOPSIN _OPSIN, NOPA (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH54000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="305" mass="33374" checksum="BDEA8BF26A9FAFED" modified="2022-01-19" version="1">MIESFIKATPTLPWPEPSPTSSVAPIPTVVPGSDPIFQVLHDTGKRTLWVVTVLMGISSLVFYVLGARVPINKRVFHVIVALASTISFIVYLALATGQGMDWKLDILKEHNKHVPNTTQEYYRQILWLRYVLWFLTEPLGLISLSLLSGLPGAHLLIAIAADFIMLGSGILGTYAGHSSRRWVWFTISAIGYLTTVYHISVHGSRAASNKDVQTKRFFGTLSGVMLFVKLLYPVALAAGALALKINVDVETILFAIYDIFSQGILGYWLLIAHDGAPGITLNVDGFWSHGLGNEGAIRISEEDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXM8</accession>
    <name>A0A8G1QXM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase family domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_453336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511167.1">
        <property type="nucleotide sequence ID" value="XM_025661028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXM8"/>
    <dbReference type="GeneID" id="37164430"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052765">
        <property type="entry name" value="PGM-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46192">
        <property type="entry name" value="BROAD-RANGE ACID PHOSPHATASE DET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="620" mass="70711" checksum="20B4A696C721BF99" modified="2022-01-19" version="1">MGKPRMIILIRHAQSEGNKNREIHQTIPDHRVKLTPEGHRQAQEAGSRLRTLLRPDDTIHFFTSPYRRTRETTEGILQSLSSDSPAPSPFPRHTIKVYEEPRLREQDFGNFQPCSAEMERMWLERADYGHFFYRIPNGESAADAYDRVSGFNESLWRLFGEDDFASVCVLVTHGLMTRVFLMKWYHWSVEYFEDLRNINHCEFVILKLNPDNGKYVLQNQLRTWSDLRKEKEEERQRERAAKGLDPVQPAPPETSVPIRRKWGGCPDGCNHGVRRRSSLRTPRAHNADHPKHQHDPQSKETTAHSATHNHRSHGNQNGHPRPVPAGTGTATPVNQQMLRAPEPALGDRSIDARPLERTLPSPAPQYEFEGVQLETTSTSRATFPTPVASTTTISHLSQPTSNPSPIPRRPGLAHLHRDSEDHLLHPPNCNYAYIHLVGRDGGGSMSGANSLAPSEDEREEKLRPSMHAYTHNHKQTHSRPKPTPSAHQVRPSQDLDNDGDDESSSKQAARPRRTRSHSHHVRNPPGLARQTLSKQVANALNQDRAGQDRLDDEPLPTDPPISKAENQQVDEHNREDSHYDDHDHEHYHHHGDDEEDDYNDEDASFEAERKHDQSIRGSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYL8</accession>
    <name>A0A8G1QYL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dual specificity phosphatase catalytic domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_89702</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512926.1">
        <property type="nucleotide sequence ID" value="XM_025665770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYL8"/>
    <dbReference type="GeneID" id="37169172"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14502">
        <property type="entry name" value="RNA_5'-triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000273">
        <property type="entry name" value="Dual specificity phosphatase catalytic domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000090">
        <property type="entry name" value="Dual specificity phosphatase catalytic domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF25">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE CATALYTIC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="642"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH55004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="737" mass="81204" checksum="AC501EF49B3A4808" modified="2022-01-19" version="1">MGSTDVPLTSPTTSRSGLVDFGASLRLWDSTYTAFTNSGAFASLARLCKAYSYDGTVNWGKVVFLTTCFITMLGCGVISSVLRRKAWGQVSGKARFRRTRKGLSKRSEGVVTSSDEEDYDSTGSLRHGTEGTVAEKTEVPQQKQSENAHDTDPGLLKKHSSYLSYTTSTATYPSIRTFFRPHPQKDKLPTKPSPIPLLVFVHGLGGSLAQFNHLLTSLSNVGPCFGIDLPGCGLSSFSPTSWDAYTVEALAELLATAIEQHRDKEAGQEVVLISHSLGCSLSALLASSTSSIGAGLKEHILGLIAVCPRAAPPPPHDVTKFRRLLHVPSPIFDLWRYWDRRGGLHSTSVNRLVGAAADPDTRGLQVRYNKQSKTAVWRRMAWGTLPSYDSNGKAVGGIPGEDVWAGVRTPVLLVAGEADAVNKPAELKKILEFFARAGCSVDDDADGVSSSPDASAVHDKMPASYDRRAHEEEFGVEPQIEEKEITSESDQPGSRRSVKTVILPAPASHALIYDRATYRTLAGIIQDFLSQHIDNRLSMGWQLQYLNTSGKWDVKNLAKWKKVAPVSERIADTFAALKMLREVDEEHNPVLFSQAYRDKIYAVIDISYENPVYNPASMEKGGIHYHKHPTVSKIPPTPDEVRDFIALVDRLQNEITEKMEKSGNPAGPRPVVGVHCHYGFNRTGFLIVSYLIERRGFSVPEAIEEFERRRPPGIRHEHFIDTLFVRYCVGLKRAPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ86</accession>
    <name>A0A8G1QZ86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-L-rhamnosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_496533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514575.1">
        <property type="nucleotide sequence ID" value="XM_025663960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ86"/>
    <dbReference type="GeneID" id="37167362"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF2">
        <property type="entry name" value="B, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial alpha-L-rhamnosidase N-terminal" evidence="1">
        <location>
            <begin position="48"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="2">
        <location>
            <begin position="382"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="791" mass="89842" checksum="0A1BF898573BA77F" modified="2022-01-19" version="1">MASPDWTRAAPWIWLPHYLEEDNRPGRLFLFRKTFQWHPSDDLQNLPVHVSADSRYRLFVNGHRVSWGPCKSYPGKWYYETIDIRPYLRDGENVISARVLRYSTLVPGSSSIVSMPLPGFMLYSPHPELAISTDPSWTCIEQRSVKIIPQTEWNYLLGPPFLSNNERAEEDQTITGWQMPGYDDATWDKAVFQSNAVKMLPIVSPWKLAPRPIPDLPEIEGRFDGIVKATGSVSEDEWKLLVREDKPVVIPANAQVTVDLSVEALMTAFVSFGFSGGGGAKISILYSECYEKDMGVETAPFPIPRTKTNRSDASGRLYGVRDFYTVTSGQDVHSFESFWFRCFRYVQLEITTTANPITLTNISLRETSYPLEITTKVDAGAELNKIWEISLRTLQNCRHETYEDCPFYEQNQFASDSRLQMLFTYQLSPDDRLARKTLEEFHASRTPDGLIVAQYPTGFASKQIPQFSLFWILMVHDHMMYFADRTLVRRYLSTVDSIIQHFEDRLDDRGLVGHFDPDTWPFVDWVQDWFVPGQIFKSCMPPAYHTAGAATVNSLMYAYALLHAAELCEFVGRISTAEEYRARAHSIRSAVNQRCTSNSQLYLDGPGVEQYSQHTQVFAILSETVTGDVAKQLLRQTVTDSSLAQCSYAMKFYVFRAAEKTGIYSELFPSMLDPWRSMMANNLTTWAEDEVNARSDCHGWSASPVNEIVTQLFGVKPAEPGFERVRIEPRRELVAAADGLLHTSRGNIKLQWAPGKPLSVEVTSKIHVEIVVDGRLVERVLGPGESVTFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZR3</accession>
    <name>A0A8G1QZR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_76465</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513511.1">
        <property type="nucleotide sequence ID" value="XM_025665645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZR3"/>
    <dbReference type="GeneID" id="37169047"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26204">
        <property type="entry name" value="Med14_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="13">
        <location>
            <begin position="87"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1042"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1054"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1083"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1102"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH55589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1111" mass="123092" checksum="70D2695BDDF894EA" modified="2022-01-19" version="1">MPGVVMDNANIGGLRHGPGNTYPQDGLSHPRGEVAQINGANAQDGPVHVNGVEKNASQTRGAETVSANHASRVTKGPPELPHITQGFFPFAKLVNRSVQQCWNDLSDLITEMAEMQVNSHEFHPSTAPTTGKSPGNQSPGNIRKKLRILEFSHAKRAEFIKLLVLSQWSRQAADVSKLIDIQNFIRTRHQAYMNALQWVGDMKRDLVQAQVANPDLKTALEVLSRGKVASMSDLGYKPPRRLTVRGTLRKLQKINRLIGARLVVQEEIPPPFRNYRVHDGRVTFSVPGEFELDLSIGEENENSQFFFVDIRFLFSPSPPVLKGRLLNELEMTINDVLQNSGLTGCFDLLHNLVLTNKVNTLFKQATELARGSWSEGLRVELLHRTLVVQYWTLKPGAKSWLEIGIRRGHRKSDSESPGLPSLKFRWMRDGGEVPCEDIAFDAENLSMEIVLRSVIALHVSHILSSAYNKIRQSSLFSTGFLSLRAHLTRIEPGDCQLDAQLTETRHLRVSIEPMSGMSILSATPTVSDRSDLERNPERSSVEDIVSRVARIRCNAAIEEIESKVKMLGFVPLNPRAWKVDIRRIFPPNVLRFTLFSHQLWGRNWIVAATSSMDGDSWWVVQLRPTVPAKGPPVPHGSGRGQSVLRSAQVVTDSFFPARYDMDDAYLANLGHSLSGILAIHSNARYLSDLQSIKFHPPPHKLKVEPDLRVPDILVRYDVSTLPSVFRAAMPIKAKKKSLIRDTIRLAFHGVDPREKCAIMVAYGNLVDSTATLGPLISSWDRSLVFQKGGSGFAMRLLAPAGHPVIASLLENLQRLECVLSVLESLQRKKVEIRTFSLSSISFVYGPERDLAASLNIHLSRNESLMELSPTELASRSESLFGLRLGIQFGLQNPHRRIQESLASSLNRSSTEAGLDTVVELLTLTLPLMRALDQLMANTSYSGPLRLHVTVRNARTYQIHYPGDEARFQLVAASHQNRSVWVLKDANSQGNSKNDDSITARLRQTLYTSKGDGWKGLETGVVAEVNKVGNLLRELEKCFAASRADPKHDPADSAANFNGSNNPGTSASETEKGTADGAKISLSDPLTTLPNDKSNLSQADTAAQKEDIIMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R022</accession>
    <name>A0A8G1R022_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_488894</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514639.1">
        <property type="nucleotide sequence ID" value="XM_025663568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R022"/>
    <dbReference type="GeneID" id="37166970"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="39"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH56717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="475" mass="53156" checksum="3F7CADB411970592" modified="2022-01-19" version="1">MMDLGYEATPPPSAGKDWVSFWNFVDRAPPLEAESVPRDILVVGAGIAGIAVALALSKELTPFVPDLRINVYERHDILSTSGGAINLTPVAQRHLDRLGVLDELDKLGPESGTDVDAIQLFSSRSGRSLGAINFTDDNGNGFGGYKGRRVMRIILSLAMLKVVERTKNVNVVFGKKLVRGKESKDKAVLYFQDGTTATGDLVLGCDGVHSNVRTHWVSPEHPSEYTGISFVQTMIDSKDIKAPVHFRSTSMNISRHGSLLASYCDRDHTQIFVAAIVQFREELLSHYKIEPGQDWRRTAAIKDALCQEMRDRFGRSGLPAIRDMVNKADDWMLYPVWQVRPGARWYRNRVILLGDAAHAMPPRDESAAYALDDAILFSRILAKHRYDPLPVAFKAYEDLRRGTVNAAFQVSRRMWEKNRDLGFLEGRLKEWTMPMQVRNGKEAREQAWGFDATKVQLPGPGDSTSSLYSSEKEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R037</accession>
    <name>A0A8G1R037_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_479111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514098.1">
        <property type="nucleotide sequence ID" value="XM_025662933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R037"/>
    <dbReference type="GeneID" id="37166335"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034363519" description="Cell wall protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="16698" checksum="7A0CA2326E1B4723" modified="2022-01-19" version="1">MNLLPLLLTLTTFLLPLTAAFTSTFQNCQNLNRLNQTVHRVHPLLEKFSSVHASQSQTAVTTTTTTLANGTTITVTNTTSSSSSAAVERIEGVRALLLSSQEKIYGRLSNCSSDAVLAPRNVLVKGSSVKRDDDDDGSCTLTDVLDQLVDTLEWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R052</accession>
    <name>A0A8G1R052_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1 family superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_423900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514004.1">
        <property type="nucleotide sequence ID" value="XM_025658030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R052"/>
    <dbReference type="GeneID" id="37161432"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.60:FF:000006">
        <property type="entry name" value="Sec1 family superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2060:FF:000008">
        <property type="entry name" value="Sec1 family superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.830.10:FF:000005">
        <property type="entry name" value="Sec1 family superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="613"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="695" mass="78792" checksum="1FA69DC4E09F68C2" modified="2022-01-19" version="1">MSSSILNIQRDLILNTIRYAAGNEWKVLVVDETSRKLIDNAVSEDDILNLNVTNVEQIEHRRSPNPTMDALYILSPLPHIVDCIMADFERKRYRKAWLVWTSFLDPQQRARLDRSQIARDQIANVHIMNADYFPRESRLITFRDPWSFPVLFHPSCNHLIRAHLEGLAQKVVSLCASLGEYPVIRYYRPRAPTHEASVLCSHLARFIQNELDQFAQFQRDFPPPSPRPRGVLLIVDRSMDLVAPLLHEFTYQSMVHDLLPISDGDKVTYKTVINEGSHNEEVKDMEINEEDSVWVEYRHMHMKDVLGKLGEDFAKFRAANPQFAEDNDKANVNTIKDMLAGLTEFQKGRDAYTLHLNMAQECMSYFQKHKLLEVSSVEQCFATGMDENYKKAKNLASQLVQLLDDDAIKQPERLRLLLLYIIYRGGILAGDIRKLLAHAQLAPQDGEIVANLDLLGARVEKPLKDDKPPVQPLFTRKPPSGPIDEEESLSRYDLNLKLILEELVRGTLDPGVFPFTRPHTDADSPGQQESLSQASLRSAKPTWARTRSTGEQPKQRIIVFMAGGATYGEARTCYEISQSCGKDVFLATSHMLSPGLFLRQVGDLSVDRRRLDIPAERPKPTAPAHLFEREAPPPPAQPVKKPVPVNLNPMAPTSGLAAMSLGPNGKATNGAAPPEKEKDKKEKKEKKEKKHRFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R057</accession>
    <name>A0A8G1R057_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_522202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513272.1">
        <property type="nucleotide sequence ID" value="XM_025665242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R057"/>
    <dbReference type="GeneID" id="37168644"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="4">
        <location>
            <begin position="72"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH55350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="430" mass="47362" checksum="08447732F8FBA848" modified="2022-01-19" version="1">MSNINHQTYHTRLEQIQRIAQHHSLQITTITPIAYQELGPCPYNNFIYKLELSQPPSSTSFPPPNPHTTSLLDETTTTYILRMSNPLAMGINPHASRIENELAAMSLARQGLESHRPGLGSLIPKIYTFCSKPTTHPNDLPWTLMEYKSGVPLDEFFPSQSETAKKSIIEQVADILAGLRKCPLPEEITHGGLALSSTDGRIISAEMTTTNGGPWSTYAELLKACLRHELHDADSSPIINGWRSNGIRNRLDSLIDRFSLPGLLPDPDTKSLIHGDLTMNNILIDPTTCKLTALIDFDFACIAHPAHEFLVSLQDLGGNVMGPYGEDPTEGRLAQALLSGDFSDDDIPGEPWWIGKTFNACLVERGVARPSDIGGMEVLCRWRGLELCVCPFHLAAEFIVKRMSEEARKGAREGAEGEVVERMGASEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0F8</accession>
    <name>A0A8G1R0F8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminopeptidase C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_449808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515006.1">
        <property type="nucleotide sequence ID" value="XM_025660240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0F8"/>
    <dbReference type="GeneID" id="37163642"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000091">
        <property type="entry name" value="Aminopeptidase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000274">
        <property type="entry name" value="Aminopeptidase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF5">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="1">
        <location>
            <begin position="446"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="663" mass="72347" checksum="7FBD8E05D161C036" modified="2022-01-19" version="1">MASSAEPQTAPFGTWDSPITAATLTSKGISFAGIAATADGIIYVNEGRPAEEGRNCIVEWRNNQPRDVLPAAYSARTAVHGYGGAAFNTTSNGKVIFADWKTHGVYILDPATCDVAAAVEPDEKIWYAAFNSHPKRPELVFAIREDHHGKEVVNELVVIDTENKKVEVAATGADFYSHPTFNPTGDRVSWIQWNHPEMPWTGTELYSAPWKDEKVGTPVKLAGNGDEESILQPRWGPDGTLFFVSDGTGYWQFYRWSPDGSDAPRAIVIEGLEKGEFAHPEWLLGSCTYVLPNANTIVAAWTQNATERLVIIDLEKNTYTFPAHIASLTGIQHSAVALTSPTSIAVIASTPTAPSTVYHISFTSNDASVPTVLRSSSSVTISDTYFSRAQHISFPRTISTHPNTLSHGFFLPPTNPKYGSAPGELPPLIITIHGGPTIHTDPGLSMMWQYYTTRGYAVALLNYAGSSGYGRAYRKLLNGSWGVLDVHDAADCARYLISEGKVHPSRIGITGVSSGGYATLQGICMFPTLFTAAVSVSGISDVEALVAETHKFESHYAFRLLFDDKVPETEEEKRKVYRERSPRFHADIIKAKLLLLQGTADEIVPLNQAQAMADDVQRSGGVAKLVIFEGEGHGYPRKAENGLQAKKVEESWWKENLAEVKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R121</accession>
    <name>A0A8G1R121_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein S19/S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_451859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512892.1">
        <property type="nucleotide sequence ID" value="XM_025660688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R121"/>
    <dbReference type="GeneID" id="37164090"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF8">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH54970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="64" mass="7069" checksum="293C3D3E0D702F0D" modified="2022-01-19" version="1">MNSLPLPRKLPAPPGTPPIKTQKRSATILPNFVGLKFQVHNGKIYQDVVITEEMVGRKLGEFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R166</accession>
    <name>A0A8G1R166_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_438476</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515270.1">
        <property type="nucleotide sequence ID" value="XM_025658673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R166"/>
    <dbReference type="GeneID" id="37162075"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF34">
        <property type="entry name" value="PROTEIN HOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH57348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="517" mass="56999" checksum="DDB8F9AC1F7E4DDE" modified="2022-01-19" version="1">MDSATTDTHTHKLGTLRLRHHETNEVILIPSPTADPNDPLNWSRKHRYFLAVVACLAVFFCNFLAAGPSVAISETTIDFLGPMGPNFSSHGVGMLFWMPLIVKYGRRPIYVLSFLAYFGTALWCGFAQSYAVELTGRIVLGLTAGTGECLGPLTIADIFFVHERGTVMAIYTAALSMGVAGGIIIDGLITIHYHWRVIYYVATALLGAVLILVIFTFPETTYDRSAAVYPFAINVDAEKTYAEAEVVENAGINRRNPPLKESYISSIKLFHGIYTKETLFGVFLRPVVLIILPPVLWSTLVSSVTVGFLVAITSNYSTAFSTYYGFEAWQSGLCFVSPLIGSLIGIVCGGHLSDWTADWFTRRNGGIREPEMRLPAIAIGGICAPVSLILYGVGIQNECHWMVPVLGLGLLNFAIVQATNVSMVYCIDCYRPAVGEVSVSILAFKAGFGFLLSFYTNPWIDQDGYAIAFGEMAAISGIIILLVIPFYFWGKQIRRSTWQWSIMRKYGHWSSDREVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R178</accession>
    <name>A0A8G1R178_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heterochromatin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_438634</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025658682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R178"/>
    <dbReference type="GeneID" id="37162084"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="48"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="101"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH57519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="230" mass="26446" checksum="E2071B9199BF8314" modified="2022-01-19" version="1">MPPPLPDISDDESSSGESIPYNDARSTKNATKADDEDEDEDEEEEDVYAVEKIMNHDWAKKGDLLLQVKWQGYDDPADMTWEPEENLLEGAKDIVEEYFRVLGGRPEKPQPQTKKRKSMGRLPKSAPEKTPEPKRRRKSRAETTTESPEKEQADEGESDDTSTWVPSSRSWEKEVDTVETIIRQPGTSNLLAFISWKNGRKSKVSLEMCYDKCPRKMLRFYESHLVFKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1C2</accession>
    <name>A0A8G1R1C2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_398952</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514634.1">
        <property type="nucleotide sequence ID" value="XM_025657079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1C2"/>
    <dbReference type="GeneID" id="37160481"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF7">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034905349" evidence="8">
        <location>
            <begin position="18"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="22"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH56712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="263" mass="28869" checksum="A9648FBE851CA082" modified="2022-01-19" version="1">MKASLLSVLSSFSLALATDSAKLLPWSPPGHGDVRGPCPMLNTLANHGLLPHNGKDISEEDIVDVLGNTLNVAESLAVALYKEAMTTVEDPNATTFSLSDLDRPGILEHDASLSRQDPYFGNDHEFNEKIFDQTKSYWTSPLIDIEEAAEAHEARWNTSKATNPDFNISETGTAFSFGESAAYMLAFEEDGIGYANRSWVVYFFENERLPQELGWTKRPFVTTGEILFNLTQRIVNSTVGVTPEVIAKLKDFAKANPSFAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1G8</accession>
    <name>A0A8G1R1G8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_520369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515576.1">
        <property type="nucleotide sequence ID" value="XM_025665129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1G8"/>
    <dbReference type="GeneID" id="37168531"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="77" mass="9131" checksum="964CDEF7589C31FD" modified="2022-01-19" version="1">MADPRPDYKAIFTQITVNLSNTLTTFGPRSPQYKCVVEMLKEFMRRVEKDMNERNRRELDPDMLSTAMEFLKIGEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1M6</accession>
    <name>A0A8G1R1M6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidate cytidylyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_499070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513192.1">
        <property type="nucleotide sequence ID" value="XM_025664053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1M6"/>
    <dbReference type="GeneID" id="37167455"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="284" mass="31373" checksum="36763EE6457B253F" modified="2022-01-19" version="1">MASTNITFSSSRWHAYLSHLLSSTQPNSPTNEALYTTVQKYEISRKLLHISVGVLVFYWHIQGVVIEKILNRNLNALIILAAGDTLRHRFISISTIYRRMVGFLMRLEEANSYNSLIYYLLGTYLVMRIFPVDVAMMGILILSFADTAAATFGRLYATKTVYLRDGKSLAGTLAACISAGLIAAAFWSYVGADQYRLERRSMFDGSLSFCHDANKMPPPPDCSAITGPWAIVIMSIITGLVAAGSEFVNLLGCDDNLTIPLLSCFGIWLFLSIFGGTGSNWVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1Q6</accession>
    <name>A0A8G1R1Q6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Maltose permease Mal61</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_460039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514576.1">
        <property type="nucleotide sequence ID" value="XM_025661692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1Q6"/>
    <dbReference type="GeneID" id="37165094"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="535" mass="58290" checksum="89F460EA91768307" modified="2022-01-19" version="1">MSTDQKSESSHLEVVDQQVRRPDTETLGIHDPASQHGRSTWQALRANPIVVLFCLYGNIGALMYGFDNLVLSLALSMTAFEQTFGTFTKGSYVIPAYWQSLWNALSQVATMLGSTAAGPIQDRFGRRAAFLVAACLSAAGIAVVYTASTPGAFLAGKIVNGLSLGLALTTGQTYISEITSLEVRGIALSGYTFCMNLGYLIAASVALPRMAMSTDAAYKVLFASGWVWPGVILLFLPFIPESPYYLVMKGQREKAGRMLSRLGNPASESPLILADIVRTHEEEQQRNEAAKEASFLECFKGVNWRRTRIILYCNALSQVIGSSFMTNGPYFLVQAGMSSAKTGMMTEIGIAFGIASSLITGYVMTVCGRRALVMFGIGLSTMLFTVMGIAGCFPHSSPALWVVGIFLELSWWVYGPAIGPAMAIAGEVSSVRLRAKSLAIGFTFNYFFSTVWNVAMPYLYNSDEADLGGLIGWIFAGMGAVTMLILFFELPETKGRSFEELDEMFAARVPTRQFRRYQCEVGLGYARKVVHDGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R282</accession>
    <name>A0A8G1R282_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_448942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515764.1">
        <property type="nucleotide sequence ID" value="XM_025660058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R282"/>
    <dbReference type="GeneID" id="37163460"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="29"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="307" mass="35568" checksum="15B9FBE12BE32E27" modified="2022-01-19" version="1">MGKKRVLVSYGVDIDAVAGWLGSYGGEDSSNDISRGLWAGHIGTTRLLKLFSKYNIKATFFIPGHSLETFPEECAMVRDAGHEIGLHGYTHENPSDMTLEQQRDILDKTYHLLYDFTGKPPRGIVAPWWETSKEMADLLLSYGIEYDHSMSHHDCQMYWLRTGDTWTKIDYSQKAETWMKPLVRGQDTGLVEIPGNWYIDDLPPMMFIKSAPNSHGWVNPKDVEELWKDHFDYFYREYDEFVFPMTIHPDVSGRPHVLLMHERIIEYINKHEGVEWVTFEQMCDEFKSKNKPPEGARMPSAPMPARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2R7</accession>
    <name>A0A8G1R2R7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTPase-activating protein GYP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_370743</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GYP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516019.1">
        <property type="nucleotide sequence ID" value="XM_025655970.1"/>
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    <dbReference type="GeneID" id="37159372"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:GTPase activator activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GTPase activating protein (Gyp5), putative"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GTPase-activating protein GYP5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Rab-GAP-TBC_dom"/>
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        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="361"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="393"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="728"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
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            <begin position="155"/>
            <end position="167"/>
        </location>
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            <begin position="206"/>
            <end position="218"/>
        </location>
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            <begin position="243"/>
            <end position="257"/>
        </location>
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        <location>
            <begin position="299"/>
            <end position="308"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00022448"/>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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            <dbReference type="ARBA" id="ARBA00072088"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RAH58097.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="863" mass="95458" checksum="3D923614F76B1F4F" modified="2022-01-19" version="1">MSSRNSAEYEGDSFDDAPEAPNTHGSLNVSIPQSSSTRSLTDSPPSGSNVATPQLTEAPPLPATSHEDHESAEETDDAGVEKQSEAEDTPRKQKLQKSPLLTAHRLSTTSLDDVNLASSNKDDESTENQPLSQELNSGTPPPLSSRDSTSSHSSRLQGSSNASTAKNQAPVAPPPPPTRSFTSPFAWLSRSSSGGKDAKSPPAQPRRNTAASISTIASNPEMGRHHEGEDVDGLGHRKPRRSSLKDQFKQLRLREEGLASENDEASVASGRASFTAGSPPPSIPEEGENGIAAAPRATSPPNGASTVNPKLAPGTVAGISTSATDASAPVDWELWQQLVNNGAQALKGANSDELNAAIKRGIPQTIRGVIWQVLADSRNPELEEVYRELIARGTDKEKQNSPNGTINGEKDSTASSSRSSVRSERSASVAHSVNGSSPSQELDPEKLSKEQAANETARKKKAKEESAALLKLEKTIRRDLGARTSYSRYFVSQGNQEGLFGLCKAYALYDEAVGYAQGMNFIVMPLLFNMDEAEAFTLLVKLMNQYGLRELFIHDMPGLHRSLYLFERLLEDVEPALYCHLRRRGVPPQLYATQWFLTLFAYRFPLQLVLRVYDLIFEEGLENTILKFALAIMRRNADTLLGMRDMAPLTTFLKERLFDVYIDKQPSASSILESGFFGSSGAADKEVYRADIMVQDACAIPLEPETIRAYTEEWEEMVRTEKEREQELDNLRHTVATQSARIRLLEEQAEASDKEHVQLASELVHLKVENEELTDMNDAMKMQVTELKNVVDKQPAEVEEKLRTEMDRIMKRNMEVQNENRSMVEQMAEMEKELVEAKMKWAEIHDEHENLKQKWSDLRKALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2T5</accession>
    <name>A0A8G1R2T5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_420674</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516049.1">
        <property type="nucleotide sequence ID" value="XM_025657900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2T5"/>
    <dbReference type="GeneID" id="37161302"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000198">
        <property type="entry name" value="Deoxyribose-phosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="59"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="379"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="731"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH58127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="839" mass="91529" checksum="80B44AA16EB2B3D5" modified="2022-01-19" version="1">MASEPKTYVSGGRVLASPPITVRIIRFVENIYLFLGLYIVSLFSLDPYTAAQNSRFNVTHSGKTPNTRARWGSGGGGGGGSWGPGGGGGGGGPGGPGRRIGRVDDIRGPECKSCGHKRPIQHHTMSTPQTDAERATLISGIQQSLPTTFPSYDISSEINRTIDHTQLALTATEQQIDDLCQEAIQHQFATVCVRLNHVSRAVQNLKEHPAVGVACVVGFHEGTYKTDEKTAEAKEAVNLGASELDMVLNYPLLQEGKYKDVYADVLEVRKAAPTPVGLKVILETSQLTREQIIAGSVLACVAGADYIKTSTGFNGPGANLENVALMRETANLVGKGTKVKASGGVRSAEDCRKMLQAGAARIGSSSGVKIMQEEKTGIASSGSGSVSFPSSTSPSHHPSSLSTPFCCPAMRRPNYKRRKTTHEDSPSSHHNGTTNSLFTEKPSAVFHPKGGRSHTLSVAIPGSIIANAHSVEQKTLLAGVIARALAVFCVDEVVVFDDDENGAYCDFHEHYYHDNSPSAKTRNQMDGGASSPKAYTANSDPSHFLTHILSYLETPPYLRKHLFPIHPNLRTAGLLPSLDMPHHLRANEWCDFREGIVVSSPGRYSARNRHSASKVTQMGNDHQFHHHSSSTDNGPVTIVDTGLSQKIILPNIHLPEHARVTVRFPQHESPYAESVHPSTPRVEAGYYWGYYVRRCRSLSSIFTECPYDGGYDLSFGTSERGRPISTVLEEKPQQAHDRYEQDHPPDREQRPPDFQHILIVFGGVAGIEAAVRNDPQLRDMAIRPSDADKLFDYWVNFLPGQGSRTIRTEEAVWMGLTSLHGLFDGTHRLKKAYKYHHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2W7</accession>
    <name>A0A8G1R2W7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_369985</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516185.1">
        <property type="nucleotide sequence ID" value="XM_025655946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2W7"/>
    <dbReference type="GeneID" id="37159348"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459:SF2">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="18">
        <location>
            <begin position="33"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="332"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="469"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="332"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="567"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="618"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="665"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="681"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="709"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="749"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="776"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH58263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="791" mass="86808" checksum="795FB15F512C2B9B" modified="2022-01-19" version="1">MAVDSGLSAAGSSTYASNTLHVGDGTWDSERDTFLLPNLMGINFDTMRYNGMGNRFKDMPEYHTLIAVHGIIATIVFLFLVPISVLIIRYYSRWNPFWAFKLHVWCQVLTLLLSTVVFVFGWFAVGPKRSLTNPHHGIGLAIYVLVIFQILWGWLVHKIERNRRSYHVPLKLVIHRWIGRALAILGLVQIPLGLTLYGSPKVLFILYAIVAFILLAVFFVLSYLYDTEGYHMEGGGYESRLSYVSGPSAADDHGHSNLGPMAAAGATGAGLASLFRRRSRGRPHDYDESHTSFSDEKLSDEGARRGGKGNLLLKLGALGGGAWLAKKFFDRRRERDNDTESGRYSRAHTRSDSMTEESLSRLEDGRRPEPTAHTPLNRPPSRPPSRPPSRPPSRPPSRPLSRPQSPGSSYLYNSTYLSEAPQRRPSHGLRDALLGAGALAAIKGFFSRRKGDAEQRRVEDMRRREMEDERLARANSKRRYPGEGYYPRRDRPASFTATDLSSDFSRPPRDPPHGESIVSAAGPPMASGAVDGARSDIPPAPGPPIPPPAASEYPGPAASTHGPTELASGVAAGTALGAASSAHRRRSASRHRSSSRPRSSSRHRDPIASPPVSVKVKMHNDGRHVTLRRLTDEEAAASREARRRERRNSRRRAGSASSLSGNEGGSHDRWRRVEELERQQQEQMQREQAAAAAAASSAFPATSATPSSSMPPPATSAYYAPPPQNGNGGYMPPPPPPPVPSSHPYGTGSIASPGTFTGTEASGDYASNRRRRRAERARARQERQQHGVEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3K5</accession>
    <name>A0A8G1R3K5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_447950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516870.1">
        <property type="nucleotide sequence ID" value="XM_025659820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3K5"/>
    <dbReference type="GeneID" id="37163222"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="13"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="278" mass="32020" checksum="53ADEFB6A213599D" modified="2022-01-19" version="1">MLSPEFSTTSATFPKFSLLPPELRLSIWQHSLPTPIHQGLYIYQRGCWETHGVSKDEFHLSFNLSSLATMKVDVPPFLVNHEAHSVAQNWLRQQAGTLLFHWTPDGFHFTRPFQPALDALYVPDSRYLEFLSEGSNLAFAPEYEGMNYKTSPPALPRLAFPRSLLECEKKVITSVFDMLEYQNFEEVLVVEDVSEDDEGRLSVLPRVQRPLGWSVVPGSETLVWLNFARAYRREGYRKDNDAVAFARLVERASVGIGAWVEWDYDRLLKVRRVRAIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R454</accession>
    <name>A0A8G1R454_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_511357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516845.1">
        <property type="nucleotide sequence ID" value="XM_025664587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R454"/>
    <dbReference type="GeneID" id="37167989"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="28"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="331" mass="35969" checksum="D81AA1ADEF47DB9A" modified="2022-01-19" version="1">MVALASKQVGVIVAFLILDLLALVALGLRLYARSFTRRELKAHDVLTIISMIMLVGYTACLLVSTVNGGVGMHIARAMVSGFDVVLGLKAFFASQFFWAVSIASFRLAILDFYIQTFTVFKFRIAAYTLATIVVLFFIGSLTTTLRLCRPIAFNWDTTLNGSCGNEATAELAAAAFNMVLDIVIVLLPLPVTWKLQMTTQKKAAADFTYCTADSAILTVAEMAVGILVACVPTLGPVLLPSRRKRFTERAKPVGGSGVSGAGSSIRSLKNNSSRWLFSKFSTNSQRNATITTTVTHDDSRDSQSELVCKHSQTPQSTGDIAVWREFELTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R472</accession>
    <name>A0A8G1R472_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_266850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517170.1">
        <property type="nucleotide sequence ID" value="XM_025655059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R472"/>
    <dbReference type="GeneID" id="37158461"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034354015" evidence="1">
        <location>
            <begin position="24"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="108" mass="12210" checksum="36359A2E638397CA" modified="2022-01-19" version="1">MWKRHNLKHIVFLYVSALSTNVSENLDDLPQHDFPIFLRKSSAIVPHWRFPATLGLPNRIGLYLFIRLINVLSVLVHGDSKSAQNLGDGRIMGISIKGENNHKALKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4T6</accession>
    <name>A0A8G1R4T6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_510232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517406.1">
        <property type="nucleotide sequence ID" value="XM_025664543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4T6"/>
    <dbReference type="GeneID" id="37167945"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF15">
        <property type="entry name" value="LIPID TRANSPORTER ATNI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH59484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="381" mass="43215" checksum="A7F312D5ACC8A79A" modified="2022-01-19" version="1">MSTTTASISTTTSALASTQTCTNPKPGKNGYLPPEACDNILLYVPSLAAAVLFCVLYGLTLICHGVQAFLYKKRYAWVIIMGAAWELIAFIFRALLTRQQNNSNYDTVYTIMFLLAPLWINAFLYMTLGRLIYFFTPDQELAGITARRYGRLFVWLDIFAFLVQLGGAAITTQTDVPTSTIMLGVHIYMGGIGLQELFVLIFTGLIIHLHRKLIYLERAGILSPGGMAGMGITTSRNKPMPWRWLFYVMYTALGMITIRIIFRLCQYAQGTDPSNPVLTHEAYEYVFDAVPMFIALVLLNVVHPGRVLQGPESEFPRVSRAEKKRVKMEKKQAKRERKEAKRLQKETRKGYQSGWWWNMGRERGSETFEILPMQEGVEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5J8</accession>
    <name>A0A8G1R5J8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_394003</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517890.1">
        <property type="nucleotide sequence ID" value="XM_025656905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5J8"/>
    <dbReference type="GeneID" id="37160307"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF2">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="40"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="154"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="249"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH59968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="458" mass="50014" checksum="66A6F0FEFDC38FAE" modified="2022-01-19" version="1">MSEYKVEYDSELDSFQLYHRYEEPQPNLDWKRAALSGPALPALGNAVAGAVGSALSNVATYPLSLIVARLQTQKVRRGTESEKSVSADEYTSVLDAARKIYAEEGIASFYTGLAQDTIKSVADSFLFFLAYEFFRQRRIRARFGTTRRSKHTVLPVLDELAVGVLAGAFAKLFTTPLANIVARKQTAKDVGGGSTREIAARIRAEKGIRGFWSGYSASLILTLNPSITFFLNAVLKYALLPRSQRQKRPSAVATFFLAAVSKSIASSVTYPFSMAKTRAQVAGSRITVGADGEQKKEDEGVSLMPAIVSNVAAIARTEGVAALYAGLPGEVLKGFFSHGFTMLAKDAVYSTIVKSYYLLLIALRRYPTPEELLQRAREQAEEFADAAREGARDLAERTRSGTEEALSHQAGGVTVDMTSSDLADSNETAEMVGDYVEDDGSAKSLYHWFWEKEGYGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5U0</accession>
    <name>A0A8G1R5U0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_468027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516182.1">
        <property type="nucleotide sequence ID" value="XM_025662228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5U0"/>
    <dbReference type="GeneID" id="37165630"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF19">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="350" mass="39783" checksum="523D627BE142AF70" modified="2022-01-19" version="1">MHPSPPIYDKPSKEIGFIPPKHPRSTHYMNYKYRRRALLTSSEPSAMTSRTTINRAMLMVPGGSSTHNTMSSEVQPYPFPAIAFQQAPLSDARSMSGSVPYAFDQTQPLHQRKPDVGTHYFQDQESYPPLFSHQTIPPQSFRPEIESFPPAIPTTDGAYFPIDQEEWLAIAVSQSSPNPTNTDYYLPESAPSSFSQSRLTPVTTASLSSATTADLDFDLDLDLDLDDLQLQSLSDTSSARSQTRDLNNYGIQNPDGTWRCAYPGCSSHAVFRRGCDLRKHYNRHRKHLFCRYEGCPQAVRGGFSSKKDRDRHEAKHNPEIPCEWDGCQRVFSRVDNMKDHVRRIHKRRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6X4</accession>
    <name>A0A8G1R6X4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_447505</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517544.1">
        <property type="nucleotide sequence ID" value="XM_025659739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6X4"/>
    <dbReference type="GeneID" id="37163141"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="90"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH59622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="448" mass="51298" checksum="B7413A8F8671278E" modified="2022-01-19" version="1">MKTVLRLCSPINSIISRPKPSRQPITSSPLHPYQHRHTSSLSSPSPPRTFPTTGYELLNNIPKLEEESLPDYRAERFYPVHIGEVFNSRYQVITKLGFGSSSTVWLCRDLQTNNYLTLKLHVRSTQHTHLPEIRISKHLQAFHTKAEHSKHVGQKYNRLVYDSFEIQGPHGIHPCILYQPSGMDICDYVQCLEGNALPEDLLRVTIRFMLIALDYLHSANVVHTDIQPTNILLGIEDTSILTDLEEEELNEPAPRKKNHLPDNRTIYATRGMPFTTGEPMLADLGEARLLLPPDTGTQTGPIMPGLYRAPEVMLNMGWDEKVDIWALGQTAWTLLQSNHLFTNTPHLLTQNDHACRFAEMIALLGHPPVEFLGARSEESWRFWDRGGNWRNHVGIPGGSLDDRVTRLEGDRKRLFLRFLRKTLSWDPGERPSARELLMEDEWVRGEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R777</accession>
    <name>A0A8G1R777_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromatin remodeling complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_393574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517694.1">
        <property type="nucleotide sequence ID" value="XM_025656887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R777"/>
    <dbReference type="GeneID" id="37160289"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000201">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000232">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="551"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="570"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="719" mass="80565" checksum="D787FE6BF4CED3B5" modified="2022-01-19" version="1">MVGKKSGKALLRDEGLERTDNNMELSSWPQIPPINQKNYYTDYLKRDDQYLAFRLQNEENRNRMAKTAKDRDRALAMAKANDLGLPEADAEDGDTNMEDAEDTATETVGSKVIVIHVGSQNLRIGLASDALPKTVPMVIARKAASSESEDQEEPCPKRLKLDDGSTMDPEKMFGPEFASQYTTMSAELKTHMRQNKRRTLPNSKEMVVNFNRRTVPETISEHNDPMRVEWTEIPDPAPEYIVGQAALRIPDDSKPRYKLYWPIRHGWCNERDYDNKRLLFLDISLILEDAFKTQLGLTSKKDWPQYSCVFVIPDIYEKSYVTQVLELLMREFAFARVCFIQESLAATFGAGFTSACVVDIGAQKTSICCVEEGMCVENSRVNLKYGGLDITEVFIKMMLYDNFPYSDINLWRRYDYLLAEELKRNVCTMNEASVSVQVFDFHLRVAGQDTRKYSFKAYDEVHLAPMGYFQPTIFDHSQKLKGRRKLIARSVDIYDGQPNDPTSAAQSLILSSIAPPPTNGQVNGDAQSNNVDVQATPSRAQQFNALSRVQELEATPRSSVAGSPAPEAVGTPQAGAATPAPSGQGQSTSQPRGPTVEERDDILPVYPLDNAILTSIAQAARSDERKMRDFLGGIMVVGGGSLVNGFHSFLEERLQALRPAFAKEIMIGTPPRDLDPQVVVWKGASVFGKLSGTNDSWIGQLEYDRLGHRLMAYKCMWAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7I1</accession>
    <name>A0A8G1R7I1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nuclear condensin complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_447207</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518554.1">
        <property type="nucleotide sequence ID" value="XM_025659670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7I1"/>
    <dbReference type="GeneID" id="37163072"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="626"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="965"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1065"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="595"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1065"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH60632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1115" mass="123382" checksum="3C1AB8BFA3E1328C" modified="2022-01-19" version="1">MPGRSARSTSTATRKTSAQPSRAGSVTPSFTIPEEPSLPEAIPTLRRDVCSLFADAQRSTTGHRKLVVRLRKLQEACCGISQKSSKKDGSKSQAEWTLPMEETLPETEFNTEVGRCVLRILPIKKSEPVGDRILRFLGAFLALASEKDAELYAADDDDEDMQNSPETPTSRLTTSLINIIVPLLATKDKTVRFRATQIIAHIVNSLETIDDDQYHAIRGGLVKRIRDKEPAVRVQAVMGLGRLAGNDDEDDDDSKAVLERLIDIMQNDTSADVRKTLLINLPLVPGTLKYLLERARDLDAATRRALYSRLLPTLGDFRHLSLSMREKLLRWGLRDRDESVRKATGKLFYDRWVEDCAGTNNDPGAGPTGQRSPPNFNGLLELLERIDVVNSGVESGIAHEAMRSFWEGRPDYREAVVFDEPFWENLTAESAFMIRSFSDFCRVENEGKYDKLADEKMPEVTALAFYLHKYMTDLLQRKKIAKETGDANDDDSVEQEFIVEQLLHISMTLDYSDEVGRRKMFSLLRESLAVPELPQECTKLAVETLRCVCGPNAAAEKEFCSVVLEAIAEVHDTIVTEDSFVSARSEISDASSTRHRSETPQSEEEKPFNKEEAKAKVLKEIMVNMKCLHIAQCMLQNVEGNLQANMNLVTMLNNLVVPAVRSHEAPIRERGLECLGLCCLLDKTLAEENMTLFIHCFSKGHEALQVTAIHILCDMLTTHPTLLVPVEQDDGETVAPPVFQKPLLKVFARSLKSSSPNSVQTAAATALSKLLLTNTFTPAGANIPPAIQEYNQTSVETLLQSLILSFFHPRTRDNPALRQALAYFFPVYCHSRLENTQHMRKVAVPVIRATLNAAEEYYSLEAEEDSDGDIDESVGQRELKALMTGVVGMLAEWTDERRVVGLGGERILAGGPANANACGFVHLALVKDILERVLGISTGTNRCSKEEKKLLFSLMSKLYIAPPVVPSRSGSRAPEGEDPFSSSVRSAQAEITPENKELAQEVKELLDEAIEEGVAAEAAGRNALVKVKNAVLKLLAAAHGGRPTSGRAREGMEEGDSDVMSVRSNMSVRSGSVRPSIEPGTMRRGFSLEPSIIEEEDENDDSRTTIVKSEGQDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7Q5</accession>
    <name>A0A8G1R7Q5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_395207</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516207.1">
        <property type="nucleotide sequence ID" value="XM_025656950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7Q5"/>
    <dbReference type="GeneID" id="37160352"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.80:FF:000003">
        <property type="entry name" value="DNA primase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="11">
        <location>
            <begin position="301"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH58285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="500" mass="58489" checksum="6B78F67F74608AF8" modified="2022-01-19" version="1">MIRQDFRRIDPKRRATLDHKKKQFATPVFKQQDYPHRLNFYEIPPTDEITLEQFEQWAIDRLKVLAEIEACSYRNKSPAETEAHITPHLQKYLPLSSNTSSSNGAADQRLKNERQKDHYSHFILRLAFSATEELRRRFVRAETMLFRFRFQRDDTRERRAFIESLNLDWEPVDDEEKQRLAEQLLAASPGLRRIDDETWYKVDWEKVPELVEKRAVFLSKGKAYVPGREQLSMIIAEFTARLERALELTSRALPRLDEDDRLTPILNHLSKNFGSAESVYTENEGFVDGAPITANNIDRLSQHFPLCMRSLHMNLRKNNHLKHYGRLQYTLFLKGIGLSLEECIVFWRQGFKGLTDDEFNSRYKYNIRHAYGDVGGDQNRRGRGYPPYSCQKILGDSNPGVGQTHGCPYRHFSVDNLIGLLQSTGVNDRDVLRGVREDVEKMRFHIACNRVFEHTHKADIKRVKEDGTWNQTDLDTIVHPNTYFKRSFLLKQMGKAPKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8N2</accession>
    <name>A0A8G1R8N2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_109321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519495.1">
        <property type="nucleotide sequence ID" value="XM_025653839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8N2"/>
    <dbReference type="GeneID" id="37157241"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF160">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="18"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="487" mass="53604" checksum="8AB6178AB6E9887A" modified="2022-01-19" version="1">MASQIDPRLYPRRVRYAALLTVNVFVFMGNMYSSGIATGFDSLAADLHVEYQKLADLISWSVLSMGLANLVWMPLALCFGKRPVVLVSMAMFVAGIIWTVVAKDYNSLMGARVFASFGYGSIESLGPSILADMFYERNYSSAMAIYALFLSAGSQVGPLIAGYLVAARGWRWFFILCLIIAAVNFVTTFFFLPETLYEPGPEEQLDVDDKEKAEAYQSHVEAVPDVNTWRRQQQQQFSYGGYWKSLFKVGLSDAARENGVFKHLARLFWLPLPMLLVPGVLIAAMMYGVVLGGVVSISTLSANIFSPPPYNFSSAALGLWTLGSFVGILVVWPIAGPLTDALSAYLRKRNNGVHKPEHRVPALIIPFVITPLGLVIFGYTVSRHMQYVIPAVGSAMSAAGLTLVPSVMLSYVVDSYPDTSGEALVLVNASKNVVAFGLSKGSVDWMTTQGVDKMFYEFAAVQWAVLALGLPLYFFGPWIRKRTSKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9J8</accession>
    <name>A0A8G1R9J8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_516644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520020.1">
        <property type="nucleotide sequence ID" value="XM_025664858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9J8"/>
    <dbReference type="GeneID" id="37168260"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="15"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="205" mass="21956" checksum="5AFFD395B102C7E5" modified="2022-01-19" version="1">MSTTTTPSKPNRITPEEQLQFLLSCIRHSNSGKIDFTVVAQECNIITKAAAAKRYERLLKSHGINSSGGSLPSANSAPAKKRTGASTSTTTATESTTPSTPTKGRKRKADGISDASKKAKGLKKMAVARAESWMQKKQHAGVGIKKEEDDDETEEDEEVKAALREEGLSDPVHGDGEELAVKEEEEAVDGEEEGVEGDDVEVDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9L2</accession>
    <name>A0A8G1R9L2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_511995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517197.1">
        <property type="nucleotide sequence ID" value="XM_025664629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9L2"/>
    <dbReference type="GeneID" id="37168031"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000040">
        <property type="entry name" value="Chromosome 21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="3">
        <location>
            <begin position="27"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="211"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH59275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="373" mass="42738" checksum="42DD0A862843515B" modified="2022-01-19" version="1">MPARLIDRYDHVPVTKEDLDWAELITLDLSQYDQPGGKESLVEQLDHAVRHVGFFYVKNFNISQEEIDRQFALGREFYALPLEEKLKYHSSADLDRGEYNGYRPAGHRILGNGIKDNVQVYNIPKFDGYHQRQQPAILADNIDEIEQFSRKCHTEVVEKLLRLFAILLELPDEDQLVRDHQYDVKGEDHLRYMHYAARDAELNKKVGGLYSPGHTDLGTVTLLFRQPVAALQILNSEGQWKWVRPQDGTITINTCDALTALTGGLIKSSIHRVHVPPADQAHVDRLGVLYFARPNNHVVLDPIKNSPLLNRLGLTKNVFTELGQHLTTEQWVKARQTQQQRRTREAKVSEDGKYSYGDKDLQILPGLDAKVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAE4</accession>
    <name>A0A8G1RAE4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_447563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517602.1">
        <property type="nucleotide sequence ID" value="XM_025659749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAE4"/>
    <dbReference type="GeneID" id="37163151"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="249"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="379" mass="43211" checksum="1C79DAC9FE86595D" modified="2022-01-19" version="1">MAFDCYCAICGVGFCGMHIEAPSETALERRRRWIEKRCRALQAGKDFRQVSHEGEENEEPVRSYDPRIVGWDNISWLYKAHCLGVDENAKPGAPKAFLSDEGYYADIGEFVVKAKSDGSRSRSQRVYSCYGHGSEEAPGPVLPFHWCCFEILTRALTGTTDTKNVNLDVLYNIMTPLCNMSGSALQLSYGDDIQRSQGRYWECIPGAEYCAAHPVETPGLDEHLQNNMETNSGLKTPFVELDLRDRKPVSPFGKLPLEIVYQICKFLPSDSLKALTEASLHIHLVTQDNLFWKQYMQQNMPWFWELQAAKNQKVPADLNYKRMYMWLEKMTAPRYGMDDVKLIGVANRRRIWGVCEDLADRYNKSLNQPTVSAMQWGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAH7</accession>
    <name>A0A8G1RAH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_456573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518792.1">
        <property type="nucleotide sequence ID" value="XM_025661456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAH7"/>
    <dbReference type="GeneID" id="37164858"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="325" mass="36163" checksum="AE31E86CCA2AA365" modified="2022-01-19" version="1">MAKLPLFRKAPARPQVGRSRSKVLWHRILRSFCYLIAWIFLILVCIGNVADKPVLRQTYFLEINLANIIPLSTPNAVLIDTIARTIGLHDFYQVGLWNFCEGYLDQGITHCSSPKPLYWFNPVEIILSELLSGATIALPANITSALHIARIASHWMFGLFITATVLTFILIFLSPLAVSSRPPQALSSDPVINQTHPQHRRRTFVLLRSLPFLILTFVTALFTVVASVVATVMFIIFRNVFTSASEDLNIDAWIGTRMMAFMWIASAFNLFAFILQLGSCCASCCGGRKTRKQLKQNSAGTASPSSTASPDVREKEHPHSPATTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAI3</accession>
    <name>A0A8G1RAI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_446615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519389.1">
        <property type="nucleotide sequence ID" value="XM_025659546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAI3"/>
    <dbReference type="GeneID" id="37162948"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034558257" evidence="3">
        <location>
            <begin position="20"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH61467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="338" mass="37361" checksum="8FB00A1B941C5B38" modified="2022-01-19" version="1">MLLRLLSATGALCITTAAAAALPAPQLHSTAGSHQINLPAIPCAFSDSTCTESFDSGSQLTIDFSTQNGTLRANQQPIFPATVPMQFTADRKWESFVQPVQVSYSLDVRPLPARPGAGLGDIYYLKLRLFDQHGRAATQNTIAISLISDAQGGLQLAMIDPNGSRDYGHGNRVWQMKAWKEQLETYYNHAKEAVKNCVKPEHPKHEHEHEHEHAHEHPHKMAGSSDAHPHRRPSSNKYYPSSQSGHFFWTGREQSIMKIARPVILPALMGIMAGGVACIVGFLLGRLIISIYLCAASRRQQQQNIPIINIEDGEPISEKEALLEPYSDQEPESRQSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAN1</accession>
    <name>A0A8G1RAN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_5690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520620.1">
        <property type="nucleotide sequence ID" value="XM_025665494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAN1"/>
    <dbReference type="GeneID" id="37168896"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF2">
        <property type="entry name" value="LYTIC POLYSACCHARIDE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034229464" description="Lytic polysaccharide monooxygenase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="41134" checksum="57C0234071DC9291" modified="2022-01-19" version="1">MFSKSILTAAALLGISAVEAHMIMTEPIPYGKDTLNNSPLAADGSDFPCKLRSNTYEVSEWNTAQIGESMPLTFEGSATHGGGSCQVSLTTDLQPTKDSEWMVIKSIEGGCPANVDGNLSGGASMADPTKFNYTIPEGISPGKYTLAWTWFNRIGNREMYMNCAPLEVQSASSSKRSDVEEKRDVEKRSSTFPPMFVANVNGCTTSEGVDIRFPQPGDDIQYNGEPSNLASAGAAACTGTPTFAAAGDSSSGSNSGSGSSSGSGSGSASSSAAAVVTSAPAATYTAPAVANTPAPSSGSSGSSSGAGSNSVSSPQPSSSSSASSSSSSGALSGSCSVEGQWNCINGSSFQRCANGQWTPAQNVAAGTQCTAGQSSNLAISAIKLKPRTVREGRARRHAHGGHVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAU5</accession>
    <name>A0A8G1RAU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Propionyl-CoA carboxylase beta chain, mitochondrial</fullName>
            <ecNumber evidence="2">6.4.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Propanoyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_515780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>butanoyl-CoA + hydrogencarbonate + ATP = (2S)-ethylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59520"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:60909"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:59521"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="2"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521173.1">
        <property type="nucleotide sequence ID" value="XM_025664808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAU5"/>
    <dbReference type="GeneID" id="37168210"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051047">
        <property type="entry name" value="AccD/PCCB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842:SF2">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="8">
        <location>
            <begin position="32"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="9">
        <location>
            <begin position="306"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH63251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="565" mass="62005" checksum="6F1232D49124BE94" modified="2022-01-19" version="1">MSDKTYKTPKEDSPSRNQATKRLRQLSAQVLPPDYSDVLSHINTLRTLASTPDPSRRGYIRQKQAGKLWVRERLEQLLDPDSFQEIGSLSGTVTWEKTGPMREKPVAFTPSNNVQGMGRLRGRKVLLTADDFTLRSGHADGASHGKTIYLEKLALALRLPVVKLVDGSSGGGSVTTIRTAGWSYLPYVSMYRHVVEQLNQGIPNLGAVVGPAIGLGAARVVSCHFSVMAADVGSLFNAGPEVVKGATFEEGLDFQTLGGPMIHCTNGTIDNLAANEAECYEQLRTVLSYLPNSGREAPPVIAADDPEDREDEALRRIIPRRQTRMYNPWTIITSVVDKGSWFEIGALWGRTAIGGLARLGGRPVGVISLNCEVNGGALDAAGSQKLARLLKLCDVMNLPVLQFIDVPGYAIGTVAERTATMRWGIELGKTYFTTTMPLFNVITRRAYGVAGGLMLGARDPVMQVAWPSGQWGSLPLEGGIEVAHRHELREAEKLGQKEARYKELEEEYRRLMNPVRTANAFGVEEIIDPKDTRRLCCAWAQHVYEVLIPERLADRAAGKIQPVFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAX9</accession>
    <name>A0A8G1RAX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_386532</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520770.1">
        <property type="nucleotide sequence ID" value="XM_025656635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAX9"/>
    <dbReference type="GeneID" id="37160037"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH62848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="519" mass="59087" checksum="E35917AAA5BA97A4" modified="2022-01-19" version="1">MNVRSRTGCLACKKRKRRCGEEKPACRNCVVRGFECPYLSENAQQINLRFKISLANGYRLPLKKQNRRHFISVSAEDVALLSSEHNQEIVPAEKDDTRTKNLNGHALNPVRLEGSVFASPLVDCSGLEHQLFQYYLQVISRVRVFRDDSRNKFRSLVVPFCCGRRPLLYAVLSVSANDRRAETVPTHINYEQLALSYKSLALKSLRKSLSDVSNASEALMTCLILCTLEIASGCQPDWVRHAKGAFAIINSCSSMIDPEILFFARSYFQSRTVFFRTTGCHDDLYDKDAERLLEPQTGIDHGMDFFSQCTTLGINYADERTEIQPHFGCSLSLLDIIARATDLVSQKQKLRRNGCNSFFSEGEMMQRAMSLRSELDLLPKEHSPDSEYLTTCGECFRMAADLYLQLACDIPLTQPALQALLGKLLDHIGKVIREDQERQLFPMWPIFLAGCLSTTDGDRERVLNYFTYLAHAWPVSNIPIVREATETVWKFRDLNPHECGSGFDWQMIISRMNWKLALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB13</accession>
    <name>A0A8G1RB13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hyphal anastamosis-8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_134884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520339.1">
        <property type="nucleotide sequence ID" value="XM_025654029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB13"/>
    <dbReference type="GeneID" id="37157431"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="51922" checksum="F037D7C1C96380A6" modified="2022-01-19" version="1">MALPSQPAVTTEERSSSEWSSSSLKGGRTARFAEATMIHSPSSPGDSGKSPFADPPSNSQTPPDVSDLGFGYVAASDPAKHASHHDIPANDQKGALKVPGTPGRTLNPLSPTFREEFFVEKQEKVTEKENQRDLRIKLRVRVAKVFLRFINLGCSMIVLTILGTTLTVFNATKSLPERNTSPPWEFGTNPWPQYLLLAVSCLSLIACLGVFWGYWRGGRRRAQKYAAYYSLLSVFLFIFQLVMWIVAAAIFEHSKATGDDKDLWGWACVHNEREQLFKDQIDYALLCRLQDWGLVCAVIEIVLEVFVLVIYGVIFYRFWSKRKLARSMDRRDRARTDLYIAQLRQNMDPNTPGFPTMPKAPFVSTSIPQDQYSAAENGQMCTTQFATPTDFKKQSAFQLQPPPIRVQQASPQPVQSEFPPPPAPAPVPSAPNQHMGAAPGERTYESVPIPGAYAGPMSPSFPHGTHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB57</accession>
    <name>A0A8G1RB57_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_106773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519436.1">
        <property type="nucleotide sequence ID" value="XM_025653827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB57"/>
    <dbReference type="GeneID" id="37157229"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032:SF1">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="485" mass="53830" checksum="CF57AB3CA1123D4A" modified="2022-01-19" version="1">MPELAHPSLSPSEDRSPRVHPRESMTLRHRGAGRSATFAEGTANLRNQRRNSTLSDTVSEARNSIRSSTDDILFPRAAKRNDVNLTNEESHWHSAPLGLALLPAVAGIFFQNGSAVVTDVTLLILAAVFLNWSVRLPWDWYRSAQAIRHADRFFDATDSPFRSEADGPQSSQAHQGDATESDDQKLRDSTAAAAASRELQIHEIIALVSCFVFPVIGTWILHAIRSKLSRPSEGLVSNYNLTIFLLASEIRPVSHLLRMVQARTLHLQRVVTLSSEDESDRIDVHDIAKRLEELEAHVAETAAARLSASTVDQAQPHTQDLETIQSAITQTAAEVRKTFQADIDALNRAVRRYEKRTAVSAYQTDSRLQALETQMHDAFSLAATAHRTSIQRPQGAFLMIVNGIYAAFLLPVQAFISIVTLPLHMSRSCLRYIRGILFSKSSPTPHPTKEKTAHGKPRSAKKTARPTSEEERKDARALGQIKEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB79</accession>
    <name>A0A8G1RB79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_444017</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520595.1">
        <property type="nucleotide sequence ID" value="XM_025658925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB79"/>
    <dbReference type="GeneID" id="37162327"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034840060" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH62673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="210" mass="23756" checksum="6A151783FECBAACD" modified="2022-01-19" version="1">MRFAALVIGLLATFVSSVAATALTYRLEANEKACFYNYVDQRNVKLAFYFAVQSGGSFDIDYSVVGPGEKVVLDGTKERQGDFVFTAQSIGEYRFCFNNDMSTFAEKIVDFEIAVENEERAQLPSRQGASPEQASALEESIFKLSAQLSTITRNQKYFRTRENRNFSTVRSTERRIFNFSVIEGLMMVSMAALQVFVVRFFFQGARKGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBG4</accession>
    <name>A0A8G1RBG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STEEP1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_444462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521040.1">
        <property type="nucleotide sequence ID" value="XM_025659020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBG4"/>
    <dbReference type="GeneID" id="37162422"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057965">
        <property type="entry name" value="STEEP1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25809">
        <property type="entry name" value="STEEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STEEP1" evidence="2">
        <location>
            <begin position="34"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="205" mass="22989" checksum="91334685F4DC8B8D" modified="2022-01-19" version="1">MSTPTPDDPTPPPPTTTTTTSTTSQQQQQQQPRLPVQTHHCRFCNHLLLATTRSIPSLPRRKDPAKDGALILPLPRDHSTTDDDEESNSTSQPSKKQKHYTILLSTTIPDRKHTLVRREDGFEKRLFLRCGRCRVVMGYFLDEVHFGGVSSAAAEEDGEGEGEKAREVVYLLPGALVETGVMMRDEELEKVVKGLDREWVGWLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBH5</accession>
    <name>A0A8G1RBH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Geranylgeranyl pyrophosphate synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_516689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520068.1">
        <property type="nucleotide sequence ID" value="XM_025664859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBH5"/>
    <dbReference type="GeneID" id="37168261"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41893" checksum="AED3A3C27C678D95" modified="2022-01-19" version="1">MPKAPLLKGLLLAIGEIPLDSIHPDPNISCTKKDLKTITSYNLLPKKEKSMVVPGTPSIYKPPTTPMHIPPDAGKYILDPNSLIFPNCTMEPLLRAISITTTTTGKPKVNLTTTDLITDRRNLRLLLSFVSSSKKPFRIDVEVIHSTVLLSLWTSSKTNFVGQFQGYGHSFEKASTWNPRYIRGSIIHNRAVRYTLGGIHILLRYEVDACMPGKPPHTSTNSTNATTNHHSPTGIKVINSGTLVHPHRIIEIKTGPVSKRLDNSKNLEQMWFSHTPILCTGQYQPDGTFLPARAQNMEKEGRLEQWERDNEEKIRKLVRVLEMVFEVVRGVPHRCALVHDGDGVLRVYQVDENAKGGLGRGVPGDLRALWDVNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBR9</accession>
    <name>A0A8G1RBR9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Raptor N-terminal CASPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_444102</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520684.1">
        <property type="nucleotide sequence ID" value="XM_025658938.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37162340"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000514">
        <property type="entry name" value="TORC1 growth control complex subunit Kog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000194">
        <property type="entry name" value="WD repeat-containing protein mip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000278">
        <property type="entry name" value="WD repeat-containing protein mip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="6">
        <location>
            <begin position="179"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1299"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="923"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="973"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="925"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="936"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="973"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH62762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1425" mass="160514" checksum="CCB526F90B84059F" modified="2022-01-19" version="1">MEPTIQQASHPEPRKSHHKSVRVAFGPDLETHIPPRDRSPAPVPGHHRSFTTVEHKQTPVITPERPTSSSAGENPLIIENNGRLTSDRSSDSARPIATLKRARSDYGPRVGLDKAIAGDEEEDIAMRHGWQEEYTSSEYLKVLHSNFYMYFTEKRHETNGIPRDPVGSWPSQDWRMKDRLKTVSAALAICLNIGVDPPDVVKTNPTAKLECWVDPTSTTGGGHNKIMEQIGKKLQEQYETLSLRTRYKQYLDPSVDETKKFCISLRRNAKDERVLFHYNGHGVPLPTQSGEIWVFNKNYTQYIPVSLYDLQSWLAGPSLFVFDVSHAGNIVSNFHTFVEKHEKENAEAKKRDPNAIVQNYGDCIILAACQKTESLPTNPDLPADIFTCCLTTPIEIALRFFILQNPLQTNISIDEFRVPGRLQDRRSPLGELNWIFTAITDTIAWNTLPRALFKKLFRQDLMVAALFRNFLLAERIMRTYKCHPISSPELPETHHHPLWKSWDLAVEMVLSQLPALIDHEEGRRQYEYQHSTFFAEQLTAFEVYLSSGPTEKNPPDQLPIVLQVLLSQAHRLRALILLSKFLDLGPWAVHLALSIGIFPYVVKLLQSAAQELKPVMVFIWARIMAVDHTVQNDLLKDNGIHYFISILNPSSPIPVGNASEHRAMCAFIVSIFCKNYPQGQNVCLSAELFDSCLKHLMDVENPLLRQWSCLCISMLWSDFPEAKWMGIRCAAPARLCELNFDPVPEVRAAMLHAVTTFLGIPDLTDQVAQIEESLAMTVLPMAADGSVLVRKELLVFFSTFVRRYQNKFLVAAYEEFQDEKQNLLLKLEQDGTRSLSLEDVPNISANGSTDPNHRSQILSRNTTFGTIWKQLLILSVDPHPDIAQDAAMVVDYIHICLLQSPMATLTNKIRNEILDLSSRVSQKYQVRERPESKKTAPPPTPPSAAPPKQEGYLSLSLKRTASVAASLKNLAFGSSSAGEAQSQQTSTAPKSRVPMTPRGRAPPEWTRPPEVNDQVAPATAYHQAPTPTSRGFEPRDPTAVPTIPLMSRFLDWSTEYFREPQMKPNEPDEPGSADYNERLWRRSRNEKIISETQPLKGVAGSSRWDNSLSLLSNSSQPLKMCFHQFEDHLAVADDRDTIAIWDWQSHKRLNRFSNGNPAGSKINEVRYINEDDQALLMTGSSDGVLKVFRNYESAKKVEIVTSFRALPELIPSNRNAGLVLDWQQGQGKALVAGDVKVIRVWNAATEVCTNDIPARSGSCITSLTSDQVAGNIFVAGFGDGAVRVFDQRLKPTTSMVKVWREHKQWITNVHMQRGGLRELVSGSRNGEIRLWDLRMDTPFSTFSATKDTLRTLSVHEHAPVFMVGTNRHEVKTFNVNGTYLSTFEPYSSFLHHNRSSPIASTAFHPHRTLLACAALNDNHINLVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC06</accession>
    <name>A0A8G1RC06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xaa-pro dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_445705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520199.1">
        <property type="nucleotide sequence ID" value="XM_025659331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC06"/>
    <dbReference type="GeneID" id="37162733"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050659">
        <property type="entry name" value="Peptidase_M24B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112:SF2">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="2">
        <location>
            <begin position="257"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="488" mass="55137" checksum="6AB0C0F933267A49" modified="2022-01-19" version="1">MLDKQTESLPLTEERPLLRQPPHQYRRSILHLFTSAGLLLLSIYALFPRLSLFSPFQQPSSVTPYESFERCSIENLRETEYYFLDTAAPISVEEFDERRNRLARALIADGADAFVVEPGYTFKYYANVSQPEWEVWEPEERPFLMVVQPYRHSSGLVTAKTTFLAPSFEAERARLLNMPFLEPIDIIPWEEHWNPYDTLKDSVIFSAHDRAPRLMVDEEMRDFIQRGLGHSGFEIVGLMGEVERVRQIKSDTEVGILRAVNTGTVEAVRQMRKCLYPGLTESEIARALDNTLRSAGLEPFFDIVLFDENAANPHGGTNGSKVLEPETFVLIDVGAHLLGYSSDICRTFFPPFLEPPTPDMPAPTRLRDKLEVWDIVFEAQTQSIRQFLVDASAASVDIAAREVITDAGYGEAFTHRVGHGIGIKAHESPYLNKGNHATLLQAGMTFTSEPGVYLVDRFGVRHEDIFLVREGGEAELLTGRRASGPWDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC91</accession>
    <name>A0A8G1RC91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF382-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_409548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520458.1">
        <property type="nucleotide sequence ID" value="XM_025657438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC91"/>
    <dbReference type="GeneID" id="37160840"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="259"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="548" mass="61773" checksum="FC7EA4372CBAB9F5" modified="2022-01-19" version="1">MGKNQLRRARKKALKSQATETSSNTPQAQAQVDENISPSVSKAASTELQITVFPDSADPLWQMYKDIVDKFEEPEDEKSSLKEPPKPEIYFDDDNEIPDEEEKESSISKRKRKELNKLSVAELKAMVRRPEIVEWTDTSAPDPRLLVHLKAQRNVVPVPSHWNLKREYLSSKRGIEKPPFALPKFIQETGISEMRDAALEKQEQATLKQKQRERVQPKMGRLDIDYQKLYEAFFRFQTKPELTRYGEVYYEGKEYETNLRHLRPGELSAELKEALNMPPGAPPPWLINQQRYGPPPSYPALKIPGLNAPPPPGAMWGYHPGGYGKPPVDEHNRPLYGGDIFGVLQPQQSVQQGEPVEKDLWGELQEPDISEDESEEEEEADSADDDDDVDDVEAGVQTPSGLETPSGLASAVPSEMTGPENIAGEFDVRKHYRGTQTEESVGQRSAFQVIPERQTQVQGFFGADRAYDLGASSNTLPVLGSDDSGKKRKRPGDVDVSVDPDALHANDGIDREDIKRLYDSQKKQSNPGWDFQEDLSDMIAHESRKRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD89</accession>
    <name>A0A8G1RD89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_475292</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519072.1">
        <property type="nucleotide sequence ID" value="XM_025662710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD89"/>
    <dbReference type="GeneID" id="37166112"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="50"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH61150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="440" mass="48296" checksum="D46FC4AE5846A0E4" modified="2022-01-19" version="1">MSSLARSANLLFRSSRASLLRPRAVNPIQHVFLGDKLAARGMATAFERTKPHVNIGTIGHVDHGKTTLTAAITKHQASKGLAQFLEYGAIDKAPEERKRGITISSAHIEYATDARHYSHVDCPGHADYIKNMITGAANMDGAIIVVAASDGQMPQTREHLLLARQVGVQKIVVFVNKVDAIDDPEMLELVELEMRELLSTYGFEGEETPIVFGSALCAIEDRRPDIGTERIDALLEAVDTWIPTPQRDLDKPFLMSIEEVFSIPGRGTVASGRVERGLLKRDSEVEIIGTTNEVIKTKVTDIETFKKSCSESRAGDNSGLLLRGVRREDLRRGMVIAAPGSAKANSKFMVSMYVLTEAEGGRRTGFGVQYRPQLFIRTADEAAEFSFPDGDQSRRIMPGDNVEMIVKTHRPVAAEAGQRFNIREGGRTVATGLVTRVLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDR5</accession>
    <name>A0A8G1RDR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_464827</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520756.1">
        <property type="nucleotide sequence ID" value="XM_025662011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDR5"/>
    <dbReference type="GeneID" id="37165413"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="82"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="382"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH62834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="432" mass="49383" checksum="F16A8377211032C7" modified="2022-01-19" version="1">MSSTASSSSSSSIYHSVGSSELDDRLGKLIMPCSKPTPSQSSDYQAVEVPDDFGTSLTSEASVSMYVLEEMKAYKMKEAFYSSKGEVLGRGAYAQVRVVYKRNSKDRTSRYVAKEFFEREEAPYDVFMRDIRKEFIVARHACHPNVVKTVDLCINERQCSIVMEYCSQGDLLDVLSIGRLSTTGKLCLFKQLLRGVSYLHNHDIAHRDLKPENLLLTERGVLKITDFGFAVVFRNPKIDPDRVRQCSNKNICDTEPYLPHEVWYSRYYDPRRLDVWACALIGRYLFNHSMAWEVADSEKDMHFQRFVLDWAGFRKSRCVSLIDWADIHEWQPGFRPTDYPSPEIWSLILLMLHIYPDKRLTIDEALNSPCIQAIDCCSPTGLETASTNSHSPPETHHHCQDPLLLSPPQHLSDTDSSTTKSSDINRRVYSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDS9</accession>
    <name>A0A8G1RDS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Phosphatidylinositol transfer protein SFH5</fullName>
            <shortName evidence="16">PITP SFH5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_443919</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Endoplasmic reticulum membrane</location>
            <topology evidence="2 16">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Microsome membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the SFH5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520502.1">
        <property type="nucleotide sequence ID" value="XM_025658897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDS9"/>
    <dbReference type="GeneID" id="37162299"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000017">
        <property type="entry name" value="Phosphatidylinositol transfer protein sfh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042938">
        <property type="entry name" value="Sfh5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0492">Microsome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="18">
        <location>
            <begin position="207"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="399"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="78"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="405"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH62580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="470" mass="51718" checksum="7240F8621DE5295C" modified="2022-01-19" version="1">MADQPEKTAAAAPAAPEAQPPTTTTTESAVSESQPQPEVEQKVEPVTTGEEAASPAPAAAATEPPVTEPAPAPAQEAPEDKKEEAKEETKETKTEEPKEEQKADEPKAEPKAEEAKKEEEQKPAQPEYLAKNPALSQFFDRLSAILSSTGYNEMWGVTLKDSSDVPTVNILIKFLRANEGNVKLAEEQLTKALQWRKEMNPLALTEGRYSAERYGGLGYVTKYPEANGKEVIVTWNVYGNVKSIDQTFGDVDGFIKWRVALMELAVKDLKLSEATTVIDYDGEDPYQMLQVHDYQNVSFLRLNPTIKAASKKTIEVFSMAYPELLREKFFVNVPAIMGWMFAAMKVFLSKNTTRKFHPISNGANLAREFPSLKEKFPKTYGGNGATLEEDAFTVNLEKAQPAPEAPKEEAKEEPKQEQTEAPKEEAKAEPAEAPKEEVKEEAKTEQPAAEEPTKAETAVTAQEAPAAEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RFD3</accession>
    <name>A0A8G1RFD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_465464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521611.1">
        <property type="nucleotide sequence ID" value="XM_025662058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RFD3"/>
    <dbReference type="GeneID" id="37165460"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="428" mass="49698" checksum="2A307C14B8CBC6EE" modified="2022-01-19" version="1">MRHYPPIIPATCNHPECVTTQQKILQSDQYTGTAPQIASQDYPLPQDLENNSMNLSFLRTCLGTFSKFPICLHRWQVQSIQYLKISVPPQQGMDTHLAEWNETSSLISLGFPNLAAISIQIYLYFPVQAVRDTFWDGGLLKFCRLKRLRGVRLSIFEFDPAWPNTRDPVVFFEYVAGSLPNLMDESTDGNKQLPSHQTPHHICFYDARDKLRDRVQQDTTIGEEWASPDSYRSGQLFFRFAPNTFPLYVRNLIHTLPRRWPHRTHADIRREDRLHRNKTDYACVYLDGVSDPEHNRYPVFGFQYNPNLRHQHNEEYIAQGLAALRLSRERLRLSVASAPYSWNRQREDGDSRPSSQSSRDQERKEEPCHQSSEGMVPAPQRRASPGFQDDSPSRRAVTSTENERPGDWRRQHTEEVFAPFIESFSMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VG86</accession>
    <name>A0A8G1VG86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short chain dehydrogenase/ reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_454337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825089">
        <property type="protein sequence ID" value="RAH51981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509903.1">
        <property type="nucleotide sequence ID" value="XM_025661264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VG86"/>
    <dbReference type="GeneID" id="37164666"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF122">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH51981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="277" mass="29383" checksum="F2F5F05F4E392A79" modified="2022-01-19" version="1">MAFARRLAILPGGLGGLGSSIGKKLRQQGARLAILYAPFEAARRDELLEAGYGELPAGEEIRTYECDITNPEAVQSVFTTLKEDVLNPSSTTTQSARAFPSILVNTAGYVSLSDLELTPPEETLKHLHTNVLGPMLCSQAFARLYLAAAEVAHSSPNPPPPGRIVNLASQAAHVALHRHGAYCASKAALLGLTRSMASEWGGRGITANSVSPTVAWTALGQKAWGQDDVREAFLKTIPTGKFAQPDEVADAVLFLCQDSSGMINGADIRVDGGFTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VG97</accession>
    <name>A0A8G1VG97_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_493425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825089">
        <property type="protein sequence ID" value="RAH52011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509933.1">
        <property type="nucleotide sequence ID" value="XM_025663826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VG97"/>
    <dbReference type="GeneID" id="37167228"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="67" mass="7380" checksum="7946727368950957" modified="2022-01-19" version="1">MFDAVMSWFRPSGQEEVQEVTWDPVTLTMNQPQSPAAPTMDEIVTDQPSLGEGMELRLRGGDGPEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHC7</accession>
    <name>A0A8G1VHC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase HEL117</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_453316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511146.1">
        <property type="nucleotide sequence ID" value="XM_025661024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHC7"/>
    <dbReference type="GeneID" id="37164426"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044688">
        <property type="entry name" value="SCI-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117:SF1">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="45689" checksum="EDA0A896BA7742B9" modified="2022-01-19" version="1">MDNPHPERTMSTRDSYSHSRSHRDRTHSHTRSRTRSRSPNRDPTSRSDRHRSSRHHHHHRHHHHRHDRHRDHDRDRHRRDRHTSRSKDQAELAPAAPIVLPFNSRELTKYDLEHYAPMFDMYLDIQKGIIMDDLPEDEVKGRWKSFMRKWNRGELAEGWYDPATLEKARTNIAQMQAQTSTNTGYRGESQQNERGDETRDRDVEGEEDEDDDEYGPVLPSTSGRGGGPSSGPTIPTMQDLELRKELAAEDAIAARQDSRAQYRSELRSHKSEVKYLQEEVAPRAEPGTHERRMEKRQEAAASNRAFAEAKRGGSPEAAPEEELMGSGENDLDSLKKAKEREQRKKNEREIRREELLRARAAEREERLQQYRQKEEETIGWLKTLAKQRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VI06</accession>
    <name>A0A8G1VI06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polysaccharide synthase Cps1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_145688</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511808.1">
        <property type="nucleotide sequence ID" value="XM_025654102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VI06"/>
    <dbReference type="GeneID" id="37157504"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06434">
        <property type="entry name" value="GT2_HAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH53886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="437" mass="51018" checksum="D74AA6D21850E0C0" modified="2022-01-19" version="1">MEFPFMRAFIALFLYRYFRLVVNLFSFWTFKPIPPPENPKLTAQDVTVILPTLEGCGDELVETIRTILDTQPYELLLVTIEANRQKAENMLSLMPASKSRIRLFTVTHPNKRRQMTRAIPEVKTTITVFADDDVSWPRTVLPWMLAPFEKDERFGGVVTCQRLRRAVSPSFSQRIWGFLGALYLERRNFDCAATTHIDGGLPCMSGRTVAYRTDILQNEGFTYGFTNEEWWFGKYQLNADDDNFITRWMVSHGWETYMQYHPEAEVLTTLEDNPKFLKQCARWSRSNWRSNLTSMFHEKHIWYRQPWSAYAVHLTTLSPPAFLGDLLLLILCHKATVSWDNDTHALAMQALGLWMFISKFIKLLGHYIRYPVDVILLPVSILFGYFHGAIKIYAVLTLNVTTWGSRDGADDYDAERMKKRTDTDRMKRPYYPSYITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VII1</accession>
    <name>A0A8G1VII1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Geminivirus AL1 replication-associated protein catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_452899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511612.1">
        <property type="nucleotide sequence ID" value="XM_025660934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VII1"/>
    <dbReference type="GeneID" id="37164336"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="25508" checksum="D2158123C80194CE" modified="2022-01-19" version="1">MTFARFRLESISDLSQSHSVVPARPSSHPSVPSDKKKHSQKIHCRWLFLTYFDSSLEQEDDFVNRFRAMLEQRSLASSTFYGCREEHAESGVLYHVLLHLEKQVNWKVSSARRYLQVSDNPHEPIKIVTRHPRVNYEDFKHSHVEYCERIALDDCFGTRPSISAAKDPRYKRKWVEVDQQPTKAAKRAKIIEILAHEYERDIDSMKSALDYERRGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIT8</accession>
    <name>A0A8G1VIT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_471635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511912.1">
        <property type="nucleotide sequence ID" value="XM_025662487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIT8"/>
    <dbReference type="GeneID" id="37165889"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="272"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="765" mass="87110" checksum="CFE494513C58732F" modified="2022-01-19" version="1">MVQLPTTVLPFSSIAKEGEEDEDEEICSLCNCLEDMTFTRETPSGRYGGYSFRTCRMKKSRVQAAYFHKGCHQCPSISQDLLCVVCKHMRLRHLIQCILLADSLTEEEVLNRPKQYQYPCSLDTISLELGCARDLEERSIYCDTCRFFSGTAKEFTNGGVKSSISIQLFLERPRKKLKDDALSSHREHNKLLVGDKAFIGTIGPTHGHRLVSTPIPQQAVDWQKVSKWVRDCHSEKHTGSCQTKPDVSRISGLRVIDTRKRCITIAPGACQYAALSYVWGAVSSLLQATMANIDHLSEEGSLNSDRLPQTIDDAIVACRKLGIDYLWVDCLCILQDEHPDQKAYWLDSMGVIYAKSFVTIVALAGENADHGLPGAALSTRRLLFSDTRVFYECYHTEHVQADFYGKRYDVKIAPIPLFCYSRMVEDFTNRDLTCESDVLRAFAGVLHTNWGQECYYGLPLRIFRDAILWTAVNKIHPRRHAAPGDVFPTWSWSSIKGPIEMREAIRTSLAIWAVPSRSSHQPDLQFITYSVWNAGKLEELKKPKFEKEVDEKVKVLYLNEKEQRLAAILAWKSHAQLCEEAHGMLGNDMREQDMNARFPSYMRQACSSGSILVYTQSLNLNQLRLGKKSQRYYEEEVFVIEAGDFVAEVITGSLNMERINLVQQKDPNSQFTLLALSVTHNDGDMSSMCMPAIPREYVWWDCSARRKMLDNIDGPSSIDDIYRPLRIELMLVETENGVSRRVGLAWAYLKSWIDQGPQFRTFHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJA1</accession>
    <name>A0A8G1VJA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase family protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_104355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512407.1">
        <property type="nucleotide sequence ID" value="XM_025653801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJA1"/>
    <dbReference type="GeneID" id="37157203"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF5">
        <property type="entry name" value="ISOCHORISMATASE FAMILY PROTEIN FAMILY (AFU_ORTHOLOGUE AFUA_3G14500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="473"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH54485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="832" mass="92467" checksum="6A52F735336BA75F" modified="2022-01-19" version="1">MSFFAQFTNLPAIATGKALLLLDFQNDFVRPNGALHVSNTADFLDLLPQLATAFRRNGEVVWVRSHYQERQPLISPTDAQDLIVLGRMDRETRTQTPDEDAFDPSAADRAGPVDEEAFLSTDSPRCCIPQSTGTQFPAPILAAIDNEADMLVDKFEYSALQDQGLILYFRTRFITQLYLCGSLSNTSVYATALDAVRHGFTVTLIEDCLGFRSFTRHEEAMRRMADIFGANGITTQELFQELDWEETDEIARKGSPRPLQSLTPAGIENVLDELEVRPSASPTTKEESPESGSSGGRRRRIDDILAEFTDNEDGDLKELASLTRSRARYGDSARGATPGGSGEKKVRARVRRSKRPDAKTESASRSDKRRSGKSKKTDIYRPGDVIGEGDSRIIYDLDLPSEAFEKIREEVSWQKMYHLSGQVPRLVAVQGKTLEDGSIPIYRHPADESPPLQPFTATVNKVRAIVERILGHPLNHALIQLYRDGQDRISEHSDKTLDIVRGSSICNVSLGAQRVMVLRTKGAAEGGESGRQTQRIPMPHESLFILGDETNRRWLHGIRPDKRPETEKSMEERAYKGQRISLTFRHIGTFLNPAGDTIWGQGAVSKSQEQAQPVIHGDASETERIIRAFGEENHATEFDWEQVYGSGFDVVNFVTAGTSKLILGPDAVANLRVRLCLSENGIRYETESMPARAAENDIRPLYIAADGTQIAGDVTILTHFAQHAAELVRPELDALRGGSQLAAIDDLLAGWRDSRRPGTGEFALTRWEQALTGQTYLGGAGFSIDDCALWPVLREIARSTTLLSDKRYPNLGQYYQRVEKRGLVKAALEEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJM2</accession>
    <name>A0A8G1VJM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">ATG12-activating enzyme E1 ATG7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Autophagy-related protein 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-like modifier-activating enzyme atg7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_376406</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513503.1">
        <property type="nucleotide sequence ID" value="XM_025656223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJM2"/>
    <dbReference type="GeneID" id="37159625"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
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        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
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        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Atg7_N"/>
    </dbReference>
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        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="12">
        <location>
            <begin position="378"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00018730"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH55581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="690" mass="76876" checksum="94D5FD8E2A0C2190" modified="2022-01-19" version="1">MRYTPFASDIEFPFYTALSSLKINHDKLDDAARKVLGLYEVRSTDLPNASCRMQIHGNALTTDETPAGFYRAEGLIKNVNTLEEYTNIDKAHILQQSAKTVWDAICDGTIYSCPSLLASFFILSYADLKKYKFHYWFAFPALHSSPSWALLERTEENANSCQTRGAVSPARGLEDAELSNLVETVKTWSYSVEDRQRGFFLARRLHGARNGTMFESNSEVTDGFTESINHDGPRWRIAPLLAYEDGFFRGARFEDCFVCFADPSNYEDAPGWMLRNLLVLVKRRWGLNKIQVLRYRDMQPDPSPGHYRSTVLTLQSDDMQAAATAESQSSTKDMPKVTGWERNPAGKLTGRFVDLTEYLDPKRLADQSVDLNLKLMKWRISPNLNLDKIKRTKCLLLGAGTLGSYVARNLMGWGVSKITFVDNGSVSFSNPVRQPLYNFVDCIDGGVKKALRASQALLEIYPGVNSTGHVLSVPMVGHPVIDAEKSRAEFDVLQRLVEEHDAIFLLMDTREARWLPTVMGKAAGKIVMNAALGFDSYVVMRHGIKAITEPSAELGCYFCNDVVAPMNSVKDQTLDQQCTVTRPGVAAIASALLVELLVSLLQNPLGAAAPAPTSRSDDRGDHPLGLVPHQVRGFLATFENISVTGRSYKHCSACSDNITRAYKEDGWNFVLRALNEPGYVEELSGLKEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJV2</accession>
    <name>A0A8G1VJV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Erythromycin esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_451962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512977.1">
        <property type="nucleotide sequence ID" value="XM_025660711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJV2"/>
    <dbReference type="GeneID" id="37164113"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009306">
        <property type="entry name" value="DUF963"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06131">
        <property type="entry name" value="DUF963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
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        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="781" mass="84434" checksum="6A3539E0D2888195" modified="2022-01-19" version="1">MAVRRSARLRSRQATEEPEAPADPVVTNNNAPCDTNNHNNSENTSEIDTTMARLGKQPERLPPVVEHEEPADAAKDAPVQRSRKRTKTETASKRKSKVEVKEPVAEVTPAIAESQSKTDATEPVVAETEKEPTPKVMAEPAAAETEKRPITKAIPEPALKLSTPKKSIPTLKGTPVNRNTPVQKNTPVHRSTPVHKSTPTRTPSSTLVRPSHQEMHPSKVRQSTTKQADSGLILGFKPIKKDAEGKVIKDTLADNTPTKAKASPAPYYGTPAFEFKFSCDSQLSDEAKKLMETVREDAAKIKAQMTLEPDQNRAEAADRKIVQPKGKASRFSDVHMAEFKKMDSIAGHASAFRATPGRFQPVVKSLKRTNSKARLDDSDRNSPSPSKIARPSPALAAPASNKRVKHDKADDASTRRPAAASPPKPVQPRPRSTVRSSLMTPTRSSAARASSVTAKPPRTSMIPSLVRSPAAKPADVPRTPQTEFNPRLKSNLPTLGNLKSILRRHQPLFSKDPAKIAAGTHVAAPDFTSNLLFGSRGTTEEPAQTPSPKKRVEFTPSVKARHEEVMFSPSPSKVPVASPSRTISDVVYPTLPVLTPEQNRVNAKSPAQATTPTIRHVRPSDVHANPLPEVAGVPHGIGHKKRTRESGEDTKTNDLPEVAGVPHGIGQKKRNRAALEDETDTENVPPVDTTADARSAKRMKMTSPSPIKAPILSARKAAAPSPTKAATPSPTKTRSHTPLRSATTSRMSTPRISTPASVRARNRGVLSVSRLNMLAQPKNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJX5</accession>
    <name>A0A8G1VJX5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_452128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512634.1">
        <property type="nucleotide sequence ID" value="XM_025660752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJX5"/>
    <dbReference type="GeneID" id="37164154"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01168">
        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH54712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="82" mass="8837" checksum="1BC4816D5368E941" modified="2022-01-19" version="1">MVLAVDLLNPAPQAEARKHKLKTLVPAPRSFFMDVKCPGCFTITTVFSHAQTVVVCAGCSTVLCQPTGGKARLTEGCSFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK85</accession>
    <name>A0A8G1VK85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cellulose-binding GDSL lipase/acylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_401321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513352.1">
        <property type="nucleotide sequence ID" value="XM_025657153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK85"/>
    <dbReference type="GeneID" id="37160555"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034899426" evidence="2">
        <location>
            <begin position="26"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="311" mass="34176" checksum="12B3A967D1CE3EC3" modified="2022-01-19" version="1" fragment="single">MKLPPSWLLASGITITMTAIPTATARPWTQVPRPRAENTTTNPTYFFTFGDSYSQTGFSASGTQPSASNPMGNPDLGIGTTTNGPNWIGYLTTTENASLVLNYNFAAGGATIDNALVPAYPGDLASQFRLFEDVYAQKPETAPWDAKDAVFGVWIGINDIGNAYYSTDAATYTPKLISRLESLVEEVYKNGGRKFLFLNVPPTSRSPLFLDQGEEVVKQHAEYLAVFNENLEGMVERFNKEKGDVTTVLYDSWSFMTKILDDPTAYGFPNATCIDDDGTSCIWWNNYHPGMKYHLLQAEDMKGVMGGLGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKF6</accession>
    <name>A0A8G1VKF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_398964</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514641.1">
        <property type="nucleotide sequence ID" value="XM_025657080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKF6"/>
    <dbReference type="GeneID" id="37160482"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="26"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH56719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="465" mass="50096" checksum="236E7BF9D8369896" modified="2022-01-19" version="1">MTFSDSKGGAWGQQWRSSPLFIVSAMAMALFTDTFLYAFLVPILPYVLENRLGLDVSLTQRVSFALLSETAIAALVTSPFIGHYADRMSSKRILLVGSLLAALFGSIVLALATSTFTLFVGRLIQAIASSFIWVVGYATIADNVQPENLGKTYGVISLVVAAGTSGGPMVAGILFELGGYWVAWSSAFIILILDIILRLLMLEKPDVQGDTDYSSNASVASDLERAPLLSSNPGLEGDMAGWKFYVYILRYRRFVCGVISYLSFAVLVSSFDTTLPLHVRDVFSWGSFPAGMMFFALQGPGILLSPICGWLKDRVGTRWPTTVGFLLLAPVMWVIGMPGDERFPWANEGDRGKIIYAVGVTVVGSVSCLLNGAGTIEATVTIDEVEAKHPGIFGPNGGYSRALSVASMGWTLGAFIGPIISGYIAEQVGYYEMSCVIAIVCLLSGVNTFFNLDSKVHFDRVAEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLX8</accession>
    <name>A0A8G1VLX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-1,3-mannosyltransferase CMT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_449943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515137.1">
        <property type="nucleotide sequence ID" value="XM_025660271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLX8"/>
    <dbReference type="GeneID" id="37163673"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF5">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE CMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="450" mass="50425" checksum="01B6BDD6000DB43A" modified="2022-01-19" version="1">MNFNVRQVQTQLFRLTVSTASLCFLLFLYISFEWSPSASAGSSASNHEDDLDSAVPAISACNGFNPATVADVLDETLTAKLPINGSAVDDFVCSIMTHDMSLSAKLDCPTTISPRYADLPVHASKSLLSKPKIKYFFALDLYQSAHIMLPLMGTIVETMRFLGPEYCALSIVEGRSTDGTYDILNRLKSEMAAMGVRYYLSTSDLNPKAVWEDRIKHLSTLRNQALEPLVSAGAGKLKPYAADATILFINDVVLCVEDLLELLYQHQKQDARMTCAFDWNAAGGPFYDSWVSRSMSGNLFFEITHDARYWLTKDMFFDDQPNQQRYARKLPVQVYSCWGGMVILDAAPFVQRKLEFRNHKDGECHMGEPTLLAKDMWGQGLGKILAVPSVNVAYEYKATREAKKGQGYVHNVLESADYKAGKEMVVWEKEPPVRIKCMPLFNQQSWVKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMB0</accession>
    <name>A0A8G1VMB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7721 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_448510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516383.1">
        <property type="nucleotide sequence ID" value="XM_025659949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMB0"/>
    <dbReference type="GeneID" id="37163351"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477:SF1">
        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="43"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="204" mass="20689" checksum="51187BA877532E93" modified="2022-01-19" version="1">MSFSNLISSALEQATSGSHSSSSGGYSGGGGGGYGNSGSYDDEFSSAQHHAQSHESSSDSSLFSSALGFLSDRKSQYSEQPDIDEEHLVQSHQRLYNGGGEQQQHDSSSLGAGAAMQALKMFTSGGGSGGSSGGDKNEFIGMAMAQASKLWEEKAGSGSVSGDKQSAVNSAAEMAFKMYMKSQGSGSSGTGGPGALMSLASKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VME1</accession>
    <name>A0A8G1VME1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_478115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515602.1">
        <property type="nucleotide sequence ID" value="XM_025662877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VME1"/>
    <dbReference type="GeneID" id="37166279"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000014">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000058">
        <property type="entry name" value="Ribose 5-phosphate isomerase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH57680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="273" mass="28343" checksum="CE5407A7FE79113D" modified="2022-01-19" version="1">MASVVEAAKRAAGKAAVENHYPKDAKYVGIGSGSTIVYVVEAIKESGIDTSATKYVPTGFQSKQLIVGAGLTAVDFDALPEGTVLDVAFDGADEVDDELNLIKGGGACLFQEKIVALQAKEFICVADSRKLQSRLLTGWKYIPIEVAPIAARRVLGALKEIGSIDPAIRVNSDAKQGPLKTDQAFYIIDAPFKTLLTQADVAAGKDGSGKDGVWEVHALSQAIKQIPGVLDVGIFSGVTGPQAQALGGVGGQKPIAAYFGMPDGSVSVRKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMX2</accession>
    <name>A0A8G1VMX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arylsulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_418611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517221.1">
        <property type="nucleotide sequence ID" value="XM_025657828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMX2"/>
    <dbReference type="GeneID" id="37161230"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF9">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034916303" evidence="1">
        <location>
            <begin position="20"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="552" mass="61028" checksum="E1655B5E4A67947E" modified="2022-01-19" version="1">MRSPWPISASMMLLPLVAADWQFKSRPDLAPPKLNITIPAAADVEKGYLFVAPFAGIADGPGEMHGPRQASPYIFRDDGELVWSGYSYYSIWATNFQKARWNGKDVLFCFEGDHNPAYGHGHGHVTFLDQHYETIRELRAGNHKIMDKHEFHVINEETALIQIYQPVPMDLTPWGASAEQQWIVDAIIQELDIATGDVLFEWSSLDHVLPDEAVLPINPGQAGAGYNSSDAWDYFHINSVDKDTDGNYLISARDACAVHKINGSSSEIIWRLGGVKSDFELGPNVNFCFQHHARFVSKDGDSEIISLYDNSAHGTENGRGHEVHTHPFSQGKIIQVNTATWKASIVQAFQPPDGLLSKSQGGTQLLPNGNVLVNWGSEGALTEFRPDGTPILHAYMDSGFLGEGVENYRAFRFNWTGLPNETPAIVSLQNDEGTTLYVSWNGDTETKVWRFYSVVDEYGSREFLGDAKRTGFETALSLPGRVVHAVSGEAIDARGRVLTATAAVRTKAEVLPPKAASVGKHEHGAAQSQVQMGGSSHWEEYMVLKLDRFSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN87</accession>
    <name>A0A8G1VN87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO85DRAFT_467368</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517566.1">
        <property type="nucleotide sequence ID" value="XM_025662185.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37165587"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3200.20:FF:000002">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000036">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2820:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.910.10:FF:000003">
        <property type="entry name" value="Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000034">
        <property type="entry name" value="Putative hydroxymethylpyrimidine/ phosphomethylpyrimidine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027574">
        <property type="entry name" value="Thiaminase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04306">
        <property type="entry name" value="salvage_TenA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="19">
        <location>
            <begin position="8"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="16">
        <location>
            <begin position="474"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="785"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="18">
        <location>
            <begin position="1268"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="17">
        <location>
            <begin position="1501"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="15">
        <location>
            <begin position="1787"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="56"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="163"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="269"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RAH59644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1998" mass="223922" checksum="883C5322B101E6A5" modified="2022-01-19" version="1">MSASRAKLAELRALRAAGKKRLSTYEVEEQGDIYEEVDDEGYKKIIRNRLDQDDFVVDDNGEGYADDGREVWNERTADYGDSESEDDGLPARGKAAKRKREEEKQRQEKINNGISKYFSSGAAPSAPKPKPVATAEDDAFMADLLGEVDTNVVPHRVPTRNIVKTEARRKVRILSPPLADRTRREKPIKRDENSDPVSPVKDQPEVNFDDDDGALPGMDDDDVPMSDPMPSSPISKAVERKSTTTPVKVEEFDDDDNDLMEIAQVTGQNDAKATSVNMAGSRPPPKFGRESTPPLASSSPTKPMPEVDASWNDVRSKLNVLSSPASSEMRSFGKLRAQDVVEEDGSLRMFWLDFTEVNGSLCLFGKVKNKQNASYASAFVKIDNILRKLYFLPREYRHKNGRDTDEEVDMEDVYHEVDGMMSRLKVGMHKMKPCTRKYAFELPGVPKETEYLKLFYPYDKSPLPMDVKGETFSHVFGTNTSLFEQFVLWKNIMGPCWLKIEEADFTAVNNASWCKFECQAAKPALISPVPDSENLEAPPLTLMSLSFRTQLNVKENKQEILVASARVYENVSLTDTTPPERLPCKTFTVMRPAGSSYPMHFEAETRKQRGTFMLEKSEQFLLSKFLALFEKMDPDVLMGHQLQEVDLSILLSRLREKKTPGWHRLGRLKRGDWPKNFNRGGGFFAERHLIAGRLMCDVANDMGKSLMMKCQSWSLTEMCDLYLGKENARQELDCEAALKTWATTKDGLMNFVNHCDADTYFIAALVLRLQMLPLTKVLTNIAGNSWARTLSGTRAERNEYILLHEFHRNKYICPDKYSSKLLKAEEKMQEGDDDESADKKKDKYKGGLVFEPEKGLYDKFILVMDFNSLYPSIIQEYNICFTTVERTATADNDKEEKVPEVPTSDQEQGILPKLIATLVGRRREVKKLMKDKRATPEQLALWDTKQLAFKLTANSMYGCLGYTQSRFYARPLAMLTTFKGREILRSTKELAESKQLRVIYGDTDSVMINTNMDTISDALKVGDEFKKSVNERYRLLEIDIDNVFRRLLLHAKKKYAAINMTEVDGKYVDKLEVKGLDMKRREYCSLSKEVSQKLLNEVLSGEDQEVVLNRVHDYLRELAEKMREYSVPVQKYVIYTKLSKRPEEYPNKGSMPPVQVALRELARGKTVRPNDVISYVVTNGDAETSSLAPAKRSYTPQDVMKPDSGLKPDIEFYLLKQIFPPIERLCAPIPGTDAVRLAECLGLDVRKYQINSSSGSNQQNADIFPLESQIPDSVRFENATRFTLTCRFCKEKSVFEGLAQSTHMCTANGIVCPNQACQKTFSVLTIVAQLESQIRAQTSKYYEGWLVCDDTACGNRTRQISVYGHRCLGPRGHAEGCLGRMTYEYSEKQMYNQLLYFAGLWDVDKARKAAEKEPTGEKKDSVTALAEFNRIRPAPPPIQRGTFSARRCLPPSTSPITCSLLVFPDFWRPGLPQLIPLDIAGSPLLTAVMSVARVLVIAGSDSSGGAGLEADQRVLAAHGCYALTATTGLTAQNTLGVQDIFVVPAEFVKKQINAGLEDVGADVVKLGMLSSAETIDVIAEALTVHQVPAVVLDPVMVSTSGSRLLPEAAIKGLRTKLLPLTTVLTPNIPEAVLLLKDAGVDVPEPTDLPGLIQLANQVCSLGSKGVLLKGGHLPLTGDNRTAQNHEEASKVIDVFFDGEDITLFETDYLISKNTHGTGCSLASAISANLAHGKDMRRAVQSAVRFVEAGIKTSIDLGKGSGPINHFHSFYCLPFSPGHFVEYALDRPDVQPAWIRFTEHEFVKRMGDGTLSEERFKSYLVQDYLYLVQFARSNALASYKAGDMESIAASAKIVLHIQHETALHLDYCASFGLSKEQMESTPETIACTAYGRYILDIGQSQDWLALQVALAPCLLGYGAIAQRLYSDKKSLREGNRYWKWIENYVAEDYTEAVRLGSELLETHMRQVSPSRVEELIKIFIRATELEISFWDMGLGGKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNT3</accession>
    <name>A0A8G1VNT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitin synthase activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_261480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517057.1">
        <property type="nucleotide sequence ID" value="XM_025655029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNT3"/>
    <dbReference type="GeneID" id="37158431"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="895" mass="97134" checksum="179070C0BD4859A2" modified="2022-01-19" version="1">MAYPQHPAQRAPPMRNYGPRAPPARGGAYQGPPPNAQYDYGYDNQYYGYSNGPQGSGRGYPGDSAVPRSYGPPPGAPRPPRGGYGPPMEARGYAHRGRPPPPQGYDSRRGYGDRPPPQMRRPARPPQSPDKMAFDNPFPSFPTKDPRGPRSIEGEMAAMDLNGGPIPPSQVPDRPHTSHSRRPPRPVSPGRGRSNYPAAPVRSASTGRPAASSVRSDRPYTDPNDPPPVPHVNRSATMPVQPTMSPPPPKPLYPGQSTYQDPYSQPQSGSHEHFDTEAWVDSYYNSAHAGEADMPNFDAMPDFAKGGVIDESLPGLEQPKAKAPIESPPSSRGGYTAFNPHAAGDTYPQSPVEARGAVAPNQFANAGFQFDLPNEGPPIQPAYAQAGAGYGYNPHPYEEPHPQDQGNWGAGMPAYPESNSGYPVPEPSVRGNPPRPYRPNQPMPVTEPAPALNQPEAVDPQKNPDALPHHPVPFRPGHDQGSKPAPVRQYNNANASAPPPAASPPQAAPMEPAASGPVTQQELQQLQQMAKSRPSDNKTQLLLAKKLVEASTVLVDSSRMDPKTKAKARERYVMDGYKIVKKLASSGYADAQFFLADCYGSGQMGLQVDPKEAYSLYHSAAKAGHAQSAYRVAVCCEIGQEEGGGTKRDPFKAVQWYKRAASLGDPPAMYKMGMILLKGLLGQAKNPREGISWLKRAAERADAENPHALHELALMYANAGPNDVVVRDEAYASQLFHQAAELGYKFSQFRLGSAYEYGLMGCPVDFRQSIIWYTHAAAQGEHQSELALSGWYLTGAEGILQQSDTEAYLWARKAATAGLAKAEYAMGYFTEVGIGVAANLDDAKRWYWRAAAQQFPKARERLEEIKQGGARMQKTRLSRSAVNQQKQNEGDCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPH3</accession>
    <name>A0A8G1VPH3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_177903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518708.1">
        <property type="nucleotide sequence ID" value="XM_025654332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPH3"/>
    <dbReference type="GeneID" id="37157734"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH60786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="104" mass="11380" checksum="844BF7A0C0BAC565" modified="2022-01-19" version="1">MSRASGASAPMFPAVGSLKHPLSLLQPVGVQRDTLIISGILTYQLLLMQYLWRVTGRLAQSSPRSLAKKSFHTHSSNRLRILNLSLPDLHCYCVAANLVVLAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPV3</accession>
    <name>A0A8G1VPV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_194747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519276.1">
        <property type="nucleotide sequence ID" value="XM_025654463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPV3"/>
    <dbReference type="GeneID" id="37157865"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="318" mass="34023" checksum="DA91E15B792D81D0" modified="2022-01-19" version="1">MQSRAVATHGCYALRLMQGPPKMAFPLGFLLFLILVLFLLLIIFSFGHFLTEILQPLLWNSMSHLHSHWVRASGLTLSSFLFASRSPNTISKSSSSDCAALRASSFSLASALAFSSCFRASSSAWVALRAASSAFFTSLSAFSARFSEAVHLEDSSSRVDCSSVVAFSFAVSSSDCKAVDADLSSATSISCCFLAASISDLSVLMVSWKVVTSAACFPVPASSSAWRLSIVFFKSDTSAAFCPLLESISNCSVSIVFFRSETSAALWPLLASSSDCSVSIVFFRSETSAALFPLLASSSDCNFWIVLLRSETSDSCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQG4</accession>
    <name>A0A8G1VQG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_362346</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519951.1">
        <property type="nucleotide sequence ID" value="XM_025655625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQG4"/>
    <dbReference type="GeneID" id="37159027"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH62029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="266" mass="28916" checksum="5A03B75769C5812C" modified="2022-01-19" version="1">MAGSTPNLYSFPNNDALAQQLRPYVLRCQNSALSRHSTFRVAVSGGSLPKVLAQALLAPGNGSPEDTAQFSKWDIFFADERAVPLDHEDSNYRLLKEELLNKIPSELGAPTVHTIDANHVNDDDPQELADLYQEELMRSFAAKDSVKLPVFDLILLGCGPDGHTCSLFPGHELLREKDSWVAAISDSPKPPPKRITLTLPVVTHALNVAFVATGGGKKDIMKQIFDAEEGRDLPSALVNQGGGEKVSWFTDNAAVEGVTFPRRGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VTW5</accession>
    <name>A0A8G1VTW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_130037</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520165.1">
        <property type="nucleotide sequence ID" value="XM_025653981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VTW5"/>
    <dbReference type="GeneID" id="37157383"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH62243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="248" mass="28249" checksum="FF2385E7A50D181E" modified="2022-01-19" version="1">MRPSFPTLHPNSNQRYPGTGRMMDGKRHSYHFWLLLGLTVTFLGVLAVSFLRMNNSADFWIPWLRVSHISCDSGALGPYLETFSYHRSESEVASPDPFSAKWMDSSSTGFVQIHEAGGKTKHYGVSMFHQLHCLESLKMALKHESHHTRYWERRGEGEGEGEDHLEHCLQYLEQAIMCAADDTIEPSFVAELPTGEKARIINGDGVVHRCRNFDEVQQAMILSEKNPLVLQRRLGEGDTLRMIMDSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QPE0</accession>
    <name>A0A8G1QPE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_239675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825093">
        <property type="protein sequence ID" value="RAH51776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509698.1">
        <property type="nucleotide sequence ID" value="XM_025654827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QPE0"/>
    <dbReference type="GeneID" id="37158229"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH51776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="154" mass="17891" checksum="0D1FE82939CB1358" modified="2022-01-19" version="1">MARNGYLILFLYFSPLPHYSPGHVPLHNISGSRWLPPPQSHFTPTRFYSPLYSSPRNGNLRAWDLCLFALHHVLSVFVKGTVNARKKVKKETRTTIVWKKECVCMCGIVLISPWFVYYVYFALQIPGNQMSKHRLVPIDMDVDREPISPQFPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQP2</accession>
    <name>A0A8G1QQP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_454492</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825092">
        <property type="protein sequence ID" value="RAH51827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509749.1">
        <property type="nucleotide sequence ID" value="XM_025661296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQP2"/>
    <dbReference type="GeneID" id="37164698"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF172">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH51827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="481" mass="54525" checksum="2C254E4573E4C295" modified="2022-01-19" version="1">MSAIPFMLMASRGFRSRELQELHQEKPVIRTGPNTLSYGDVRAIKDIYGHNTKCIKDPSYVVTAGTHYHLADVVDKGDHARKRKVLSSAYALKNLETWEHKVSDKVEKVVAHFDKVCTAAPSAAVASGKVAPDPKDLTVDFRAWTNYFTLDAIADIGLSEKLGFLDQGSDVCIAERKDGSTYTVNLREALYPTARKQSLILWNYEWYPVLNKLVNVIPFFGRMQKSSDNWDNIVWRRSIERLRRYEAGEKLDDFFQALMEDKNGRANNLEWGDVVSEVNIMMNAGSVTTAIAIANVMYQLLRNPDCLAKLREEIDAVLDADDVVAPYDKVKHLPYLRACLDESLRIFPPTSHGLPRETPEEGMEILGQWVPGKTTVSMSAYVAHRDERAFPKADQYIPERWLGEEGKALQPYFVAFSAGARSCIGRNISYLEQTKILASLVHRYEFALPHPGWELKRLETMNLILGDMPVKVWRRQVPATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQU1</accession>
    <name>A0A8G1QQU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_432666</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509824.1">
        <property type="nucleotide sequence ID" value="XM_025658391.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37161793"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000287">
        <property type="entry name" value="RING finger membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057211">
        <property type="entry name" value="DUF7889"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25417">
        <property type="entry name" value="DUF7889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="730"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="763"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="792"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="938"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="966"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1016"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1063"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1122"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1154"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1324"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1369"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1421"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1466"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1507"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1552"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="15">
        <location>
            <begin position="35"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="335"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="494"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="577"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH51902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1612" mass="178203" checksum="1611F124405ADCBA" modified="2022-01-19" version="1">MEFPEGSSRDYTHSTSFPDLMNDPAYQTNYKGKEREYEEPDTCRICRGEGTEEEQLFYPCKCSGSIKFVHQACLVEWLSHSQKKHCELCKTPFRFTKLYDPNMPQNLPAPLFLRQLLIHSFRTIVTWLRFVLVAFVWLGWLPWSMRAIWRALFWLADGRWSGADAPQQSSSEHLAQVVANGTASMNVGAATTALAGASDVPAVQSPVSSMFSFSSGEPLLLTVIKKAFSALFFPAMSGTGSLSTSPSNVTAGSYKPRRPSWLSDVEFLNTLTPSPTINNILIDTLEGQLITLLVVISFILIFLIREWVVQQQPMANIAEGEREAAVQLIANNRPVQRPEEVQPELHAPQPEDVPRDESTHEHVEDISNRADEGGLGSLAETESYRVHSSFRDGSSSSSSDSGTQGHSTLQHMFRRNSDSEDELNPLSLEHSTSHGNQVWPGVDTFRDLWARGRGDPEQVLRLVREEGRQDELGWIVTAMTKLQRNDSLRGSWRRESPLHEAASSDSFADQTEMQSEPSLARSPLLEPSSSAVNRHPWDIASVSGPLGTGASDDRQDRESTNDDLGSSLRAVGDSEVPSDSTPSADTGIQSDQVPGASASTNAVTPNAEGPSENAVATPQNDQAAAASPKNLIARLFDWFWADLETPDQGQDRPQEDDDHVVEDPALEAPFVPIQNNRRLANEAAPNNQAIAPDFGLDANDAEAVEEGDDLEGILELIGMQGPIFGLLQNGVFSALLISFTVAIGIWLPYLWGKIALVLLANPVQLVFGVPMTAISVVADVTLDTLIGSLGYVMYWLSLICKVVLSPFGAFVPLGEWIPQTKSVTSASLSLIDASSHRLRNVLQAFFVFHESDVPMFSVLSHQALKIHQARIAAFTHTAFTVGKFILHDFPLRIVSHGPVGAFSVENGFGGLTQLLVQARDQVYGLVHQLLYTSKGTSWFGSSVSGSASAGITISYDLAVWDTKDRVIAIFMGYLLASALGLLYLRFTNMLSGGERGQRVEGIVADILLQAGGVMKVILIIGIEMIVFPLYCGSLLDVALLPLFENATIASRLEFTSSSPLTSLFVHWFIGTCYMFHFALFVSMCRKIMRSGVLYFIRDPDDPTFHPVRDVLERNITTQLRKIAFSALVYGALVIVCLGGVVWGIYYAFDDVLPVHWSATIPVLEFPVDLLFYNFVMPLAIQSIKPSDGLHNLYDWWFHKCARFLRLTNFFFGERQVDEEGYHARRTWWDVLSAAKGDPEHPVVDGHPQNDDSEKPSVYFARDGRFVRAPASDQVRIPKGSQVFLEVTESNQRVDGAPDTDQGLHGRANDMFTKVYIPPRFRTRIAAFILLIWVFAAATGVGITVVPLIIGRKVMSSTFPHRPLNDVYAFSTGTSIVGTAAYILYYSRPFITAAKNRLSPYLQSPREACVGVMHIVLDAARITYVLATFAVLLPSLVALVMELYLLVPAHTYVGGAQAHVIHFIQDWTLGVLYVQMAVKFVLWNAASRPAAALNAIVRDGMLKPNAKVTTRAVLLPVMLLATLAVVVPLILGFSMNATVFSSTPEVQSKVYRYAYPATLVISLMGWLVYLVRRQVEIWRVNIRDDVYLIGERLHNFREKRARDVGVPRRVITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRC9</accession>
    <name>A0A8G1QRC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ER-golgi SNARE complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_209597</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510131.1">
        <property type="nucleotide sequence ID" value="XM_025654605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRC9"/>
    <dbReference type="GeneID" id="37158007"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000007">
        <property type="entry name" value="ER-golgi SNARE complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="251"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="175"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH52209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="343" mass="37712" checksum="E8BC475265634523" modified="2022-01-19" version="1">MTGPSIQDRTGEFHAILGQAQKRMAANKASAQRQALLTDAQRKQANGSADGQGGKRRSEFARRAVEIGRGITATTAKLQRLAELAKRKTLFDDRPVEISELTFVIKQDLASLNQQIASLQALTLSQHPKSNRSKADQEGEHNDNVVVMLQGKLADVGANFKDVLEVRTKNIQASRSRTENFVSSVSSKTHSALDTQRSDSPLYNTSGRRTPQPGGASDLLTLEPSNPSPLGRPSMHSDQQLLVMEEAQTSNAYIQGRGEAIDAIERTISELGGIFGQLAQMVSEQSDMIQRIDANTEDVVDNVQGAHRELLKYWTRVSGNRWLIAKMFGVLMIFFLLWVLISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRN9</accession>
    <name>A0A8G1QRN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_199439</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510510.1">
        <property type="nucleotide sequence ID" value="XM_025654512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRN9"/>
    <dbReference type="GeneID" id="37157914"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000002">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 19" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="18">
        <location>
            <begin position="223"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH52588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="518" mass="58253" checksum="48E79E31FCB9429C" modified="2022-01-19" version="1">MATDMTSPILDALSASDASILSSEAFPSTPSLNVKAALDRLASRQMVEYETFDKEVAVLTPEGEEIATNGSHEAKVFQAVLAAMDGLKIAELPGVVGKDNAKIGQGNAFKKGWIKKDKDLLRATTDTIVDETRELLLTVKNTQTLNDQKALTDLKRRKLVALQKVISFKISKGPKFAREFVKEETDLTAEMLMNGSWKTAQLKPYNFKAKGAPTPAGAFHPLNKVRQEFRNIFFEMGFEEMPTNRFVETGFWNFDALFVPQQHPARDLQDTFYIADPVKADPPREDPENDPHRPKSIQPASNAAQEKPLDYKQYWEDVRQVHENGKYGSIGYRYPWDADEALRLVLRTHTTSVSTYVLHKLAANPRPARYFSIDRVFRNEAVDATHLAEFHQIEGVIADFGLTLGGLIGFMEVFFAKMGIHQLRFKPAYNPYTEPSMEIFGYHAGLGKWVEIGNSGMFRPEMLEPMGIPKGMQVYGWGLSLERPTMIKYGVSNIRELLGHKVDLGFIESNPAVRLEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRS4</accession>
    <name>A0A8G1QRS4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_407387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510570.1">
        <property type="nucleotide sequence ID" value="XM_025657362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRS4"/>
    <dbReference type="GeneID" id="37160764"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815:SF2">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="2">
        <location>
            <begin position="507"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="644" mass="71260" checksum="9D8FF3D8B880771C" modified="2022-01-19" version="1">MAIPALQGWHPGEVAIQRQLGYATAVSSHWTAVENQLREQHQLFHTSKLPFIPLTTTDADGRPWAGIVAGSTGTVGFVDSSSLKSLVFRARLWDGDPMLETLREWKPLEDDQVKGPILQERFLTAGLGIEFSTRRRNKFAGKIDMVKARSDQDYDFRVDITEALGNCPKYINVRQLDPYPRAKPHIVYQSLHMAPTEDLPDEVIDMIKSADTVFMATIHRTDPASAAMFPSHAGMNSRGGFPGFLRVRPSDRRSIVLPDYSGNRFMSSLGNIESSGLAGFTIISFTTGDILYLTGTARNLVGLSALEMMSRHAAVTVLETTGFTLVRNALPLRQHNGSEVGRSPYTPKVKYLVEEGETYGGGMQGHKAVLETGMQLSNDLAVFRFKVVSESGVQPLRLRPGQAIVLDFMDWIGPPQYQHMADSAPGSINDDRVRTWTVSSAHEGIDVTWFELTMREMKGGVVTTAFFNLLRMSPPNSRYYPVSLKGNVVSDIVGVTGDFVLNKEEVNLLLVAGGIGVTPFLAMLNALSKREKAARGDIVLVLSTREPDTMLTLIRRAMDMVPPTVTVKIDLFTSRPLNLDTRTLKHEDTSLSVFEGRVGPEYWKTSVREKEVFICGSKAFADTAEEGLRAIGVPSERIQREGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS30</accession>
    <name>A0A8G1QS30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1295 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_407232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510735.1">
        <property type="nucleotide sequence ID" value="XM_025657357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QS30"/>
    <dbReference type="GeneID" id="37160759"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF23">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="371" mass="42882" checksum="179721DB99362A1B" modified="2022-01-19" version="1">MALPLPDVKSVVDCASFSHTVLPFLSQITALPERLQLAAAAKDVNILKDIYLSTNPFISALFLSLALSVLFIIASEINRNYSQVDRLWSILPSIYNVHFALWARLSGLQTQSLDTIAAITLIWSARLTFNYWRRGGYSIGSEDYRWQIVRSKVNNRFVFFIFNIVFISLTQSLLLLLITAPTYNFLLLSRLSDHKSFEVPDLVFSRVAFFFIIIEYFADQQQWNFQTAKHNYQQTARIPDQYKGQYEPEDLERGFVVSGLWSLSRHPNFLCEQAIWLTLYLWNCYRTESYVQWTGIGVLGLLLIFQGSVRLTESISAGKYPKYKEYQARVGRFIPRFSVKPKYKSSKKKARKAVTEQPESEQTHEADKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSB8</accession>
    <name>A0A8G1QSB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NCS1 nucleoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_472490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510604.1">
        <property type="nucleotide sequence ID" value="XM_025662558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSB8"/>
    <dbReference type="GeneID" id="37165960"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF1">
        <property type="entry name" value="URIDINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="559" mass="61680" checksum="7898D3AEFC97E754" modified="2022-01-19" version="1">MSSIWEGIHERLLVKSVDQNGNIRPVGVLDNDSIRPTPTKDRKWTRLTYLFFWFSATANVSNLYASSTGVSMGLTMWEAIACSFTGQFLAGCLMALNGRAGAMYRIPFPVLCRSSFGPWGALWPTFNRAVMSIVWNGVNVTQGAQCLYVFLHAIFPSIARIPDRMGPKSALSSAQMICFLVYWLINCAFLVVPVPKMKKLIYIKVVVYYGGAFAMLAWAVRLAGGNPPAIHEASTVHGRAKSWLICKFLFLGLASCGTFISNAADLQRYARKPSDVILAQVISFPLSGLLVAVIGNIIAGCSRSIFGELIWNPLTILDKLMDGERYTPGNRAACAFISLAFVYSTVFSAIFENSIPAGNDIAALLPRYITVKRGFFICAILSFAICPWYLLATAAVFITFLSSYQIFLSAIAGVLICDYYLIRRGWLDIPALYTARTDGVYYFFHGFNLRGFGAYLVAVAPNFYGFLNQMGVKAPLGIQRFYFVAYPVGLLIAFGVYYLGCMVWPPAETENTSGWKEPKEYWDEFDPDRVDGVEAVTVLPVVVKDENGAKSGLDVSGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSD5</accession>
    <name>A0A8G1QSD5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mediator complex subunit 27-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_170409</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510900.1">
        <property type="nucleotide sequence ID" value="XM_025654286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSD5"/>
    <dbReference type="GeneID" id="37157688"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021627">
        <property type="entry name" value="Mediator_Med27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11571">
        <property type="entry name" value="Med27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="36810" checksum="972E2CD6C2E391D1" modified="2022-01-19" version="1">MASAPNPGQTLPRMPVVVPAMVPPSNGAEASTGAASNTDPSPDAWDSETQLVSSLAKLQKMEAMIHQLRTLLPERLLEPLAPIVNPKAAAGRSVPKSPQMLYEQLAQAARAGVSELQEFQSMWRSPEMKAVWDRVDAQIKENGGVMLQPTGKWERDYDTILADLREEEQAQTEQQQKANEEMERSKIQATEGGWRAIVDGFAQKNVPGVRVLASQSEAAVTVVLVKAGIVFRVEAIAGRDGNGVPDWRVFTRTPGGQTPSKVETAVTQCLNARPRQWDLLYLLDMISSYSTIKQTPCAKCAKMTDSTATLPTIRKPSSTPQEQGSQTWEAYHQGCAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSK4</accession>
    <name>A0A8G1QSK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein YAE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein yae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_208539</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The complex LTO1:YAE1 may function as a target specific adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">May form a complex with LTO1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the YAE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510078.1">
        <property type="nucleotide sequence ID" value="XM_025654595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSK4"/>
    <dbReference type="GeneID" id="37157997"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038881">
        <property type="entry name" value="Yae1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829:SF0">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="11">
        <location>
            <begin position="46"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH52156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="218" mass="23541" checksum="63E38ED1C7A8084D" modified="2022-01-19" version="1">MSTLDDIFGSSPPPTTHHSHPHPPSTTTTTEPSDLPSLRRQHVTAGYRDGISASKTSHVQAGFDAGFPIGAQLGMRAGTILGILEGVLRGYDESQKAVVKKLPSAGGRKGATSTNGTATSTTSTPTITDEERQAKRAEILALYQQAVKELDVRKVFEGISEKEISEGEKAEIRLGRQGEGAIGKWEEKVRVPRWEENMDALEMKDTTAAVEDKEVEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSP7</accession>
    <name>A0A8G1QSP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_408535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510138.1">
        <property type="nucleotide sequence ID" value="XM_025657403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSP7"/>
    <dbReference type="GeneID" id="37160805"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH52216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="396" mass="44746" checksum="0395F16FAB8346A1" modified="2022-01-19" version="1">MGGTTVIIRDIKHLSSVWRNTSALSYDPFTSRMLMAFGITPHHVRNLYKPEPARLLPDEQTRERSLLSCANPKKLSYMHLQSQWFKTQLLPAQSAFRTFFGEELFEIEPEFTRIYQRWEDASWKIFYNFPHFLAPGLQADRKRVIAALAVYLDLPESKRKNTAWIFGAMNSELTNLGLPAHDRAGLIMMICWAINNNAHYIAFWMFAHILTNPTLKASIESEISACFPSPTSDQGCDMEKLSNACPHLNALWAEALRLYNFSTAVRKAVDDCSVGTKIIHKGDQVFGPVRNFHLAEGVFSSGAADFDYTRFLKNPKIRQAKEYFPFGGGHTLCPGRYFAEREVYLLVAMSLRRFKMEVTTADGDVVESPKVPDIRMDLPSLAAAAPAGDLFVTVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSX5</accession>
    <name>A0A8G1QSX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ABC multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_452901</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511618.1">
        <property type="nucleotide sequence ID" value="XM_025660935.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37164337"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001530">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="712"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="833"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="859"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="936"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="69"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="395"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="716"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1040"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH53696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1291" mass="142490" checksum="4D6A67CC639C3A49" modified="2022-01-19" version="1">MGYSRESPTGQSPTEKPREDTIVIGDQEKPSTVDEKDTEEQKKSEENASLGNYIRLLSYTNSTDRVILAIAMVCAIGSGVPLPLMNIVFGSLVGEFNGYFSAGTSVTQADFKASVSRLSLYIVYLFIGKFTLTYFSMYCFRVIGLRVSATLRHDYMQTLFAQPISKLDQVSVGAVTNTITTLSNSIQQSISDKLAILFQSVALLLAAYIIAFKYSWALTLVTSSALLFILIAVSITLPRLTQAQQSVDKADEKQSSIAAEVFSSVRTVVSLGAEGNLATKYALWVEEARKRGRKMSVFLGFQFGLIFFAMYSSYSLAFWFGLKLFRDGHIGSINTVITVFFSVMVAVSVMGNIASPLIIISKAASAAGAFFEMLDSEKIDASGLDGSDASAEVDIILENIHFAYPSRPDTKALNGLNARFQRGKTTALVGPSGSGKSTIVALLERWYQLSGTSDKDQGAIYVGEHNVNDLDRKWWRSQVGLVQQEPVLFNDTIFNNISLGLIGTKWEHESHEKKKELIENACREAFADEFIQRLPKGYDTPVGENGTKLSGGQRQRLAIARSIVRQPSILILDEATSAIDVRSEKIVQAALDRLSRNRTTIVIAHRLSTIRQADHIIVMKGGVDIEQGTHEDLLKIDGGVYSGLVNAQKVELLDDDTATSDITEELKEDLEPADELVRMSTNQDGKQSTKKNKGFFGSIGLFLYEQRALWRFYIPVVASAAGAGAAFPLQSWLFAKLIAVFQLTGQSLAHAANFWALMFFILALGTAASYGLMGYSSNRFSFEVSSFYRTQYFHNVLNKPIPFHDQIENASGSLVSRLATDPKQVQEIVGINGAFPLSSIFSILGCIIIAFTFGWKLSLVAVFAALPCTFLAAFMRIRYEIQFEAMNAKVYSGSSQFAAEAIDAFRTVSALTMEDVILDRYSNLLRDQQTKAFRKAWYATLIFAFSDSVELCAMALTFWYGGQLLASREYQPTDFFVIYIAIIQGGQSAGQFFSFGSNVAQAIAAANRILSLRPDKAEQQEAQIIKSQPESLRTHSGANIEFTNVAFRYPSQDTPLFTNLNVKIESGQFVAFVGPSGCGKTTVISLLERFYTPYQGTVLINGNDIHSIDASYYRRSISLVAQEPRLFEGTIRDNITLGLDEHEYTEDDLIQACKDAEIHDFITSLPEGYSTDLGIKAQTSMSGGQRQRMCIARALLRKPSLLLLDEATSSLDSQSEKVVQAAMERLAAKRCMTIVAVAHRLATIQKADTIFVFGESRSGYGSRVVEQGSHQELLRNKGTYWQMCQENALDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT94</accession>
    <name>A0A8G1QT94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_201777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510408.1">
        <property type="nucleotide sequence ID" value="XM_025654542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT94"/>
    <dbReference type="GeneID" id="37157944"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="177" mass="19778" checksum="53AF8B420E944855" modified="2022-01-19" version="1">MFLFCSCSCACACLTDKSISVESHQLLPRYKKKSDVGPANGANIGRCVSAQPGFSFFLFSFFFFLFSLLPFAFAQILWLEPGAARWRSETIWTLLINTVSGHVADPIPTSMAHVPSSESPDPVIVLSRRTIRSQRARTLSHASHLANGHFTAPCLVLPTPVRLHRHWPRRDIGQHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTJ6</accession>
    <name>A0A8G1QTJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_406032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511331.1">
        <property type="nucleotide sequence ID" value="XM_025657322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTJ6"/>
    <dbReference type="GeneID" id="37160724"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="80" mass="8573" checksum="17ECEF430DF00CC0" modified="2022-01-19" version="1">MGSKDRRKKSIDGILKVVVANWRESNGQYYLLEAVNGGLVETADGLISQAGLSSAVWEIGSGNLEGHRTIPVTTGLIFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUC2</accession>
    <name>A0A8G1QUC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_452922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511654.1">
        <property type="nucleotide sequence ID" value="XM_025660941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUC2"/>
    <dbReference type="GeneID" id="37164343"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="60" mass="7083" checksum="CB0E096C73F6BA92" modified="2022-01-19" version="1">MIYQSPPTCYGRIHDTPNILEAFQWRMPISYWQKLCNPTLIFEVHDIVEAGTPIHWAYSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV61</accession>
    <name>A0A8G1QV61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_523085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512171.1">
        <property type="nucleotide sequence ID" value="XM_025665317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV61"/>
    <dbReference type="GeneID" id="37168719"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="359" mass="41381" checksum="840C77DE13CD8E72" modified="2022-01-19" version="1">MNDPLKPYLKFSDADRQNFYTESPNLNLVTVTITRSKEHQEPKPCYFYWSPSTDEGFRVFRDSSSEGLMEVEVQSDCSSPITRQSNPLHLWYLGADDEAVSWDIPLGENICRSVIKSEWIKYELFWPGGEVHFWDWGSKDTNEETLEVTAGGEIDPDDTAWMRTMLLQFNRSSPGVPIFSLEIEGPPTWRIQERWPLTWKLTYHGVSGDETPRPITFSVGDLYDWEVSCFYRRSQDTGEWESWRGDGVCGYGLFEDEEVPRTVGTSDGFMSLQPNETWTEVQKLDTMVDLPEDARDGEVMRHRFKGCKWTWWDWGTKEDHMDTIVMVVGFGVITKPADNDGRPEVVVPASNMVEFTAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVB5</accession>
    <name>A0A8G1QVB5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_500550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512430.1">
        <property type="nucleotide sequence ID" value="XM_025664130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVB5"/>
    <dbReference type="GeneID" id="37167532"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="15"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="417"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH54508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="618" mass="69287" checksum="23A717DB27F51E5C" modified="2022-01-19" version="1">MTIETYQFGAFKSQRTDVLIVGAGPAGCMAAATLQRYGIDFCLIDKRATRTQTGHASAFQPRTQEILQTMNLLHDLDKRGHRLTETSFWMRDSTGALVSNFTGAEVVHATPYQYLFNTDQGMTEDVFEQYLSTKGHKVQRFMELVHYEHSPESEWPLTAYIKNNASGAIEAWQTKYILGTDGARSATRRATGVQSSSQGGEDVWAVADVYVDTNFPDYRRRCAIRTPDGGCMLIPRKDEGLRIFLQVDEKSQEHLNANGDSAQDALTGSSAFKLTQTVQSHISKVIHPYKMNITDIVWISQYRVAQRVVHNFSDPTKRVFLLGDACHTHSPKAGQGMNVSISDAYNLTWKLALVMKGVAKASLLETYEQERLWVAQQLIEFDALFARQFGQKDKFDSQNLRETWEMGHGFTSGCGYEYPPNLLVNRDVRISINNEAVEPLTPGKRLLPIDLIRHIDGNHVRMLDIMPSNGRFHLFIFAGNDLASPTLQNLGNALDSPHSPMSLFNLLPLELMQRFRHEDITTDSVPFTNKAYVLDLFLIHSQNHLDIQLGDIPAPFSSKWPMNVYSDFSGAAKSQLGVSGDSGALVVVRPDGYIGLVTGLDNVEDVTSYFDGFMHRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVI0</accession>
    <name>A0A8G1QVI0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_500328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512351.1">
        <property type="nucleotide sequence ID" value="XM_025664109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVI0"/>
    <dbReference type="GeneID" id="37167511"/>
    <dbReference type="Proteomes" id="UP000249526">
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    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="175" mass="19337" checksum="C5E2ED8AC163C1D8" modified="2022-01-19" version="1">MTGSKSFVGAFAPRSSGKPYASTADMVMELNMLTETMKDMTSQIEQYQGGMSNLLYLTRGTYKVYDSALIAQKRIASTEVTEGRDEEDQVLTATYEMINALTQAIVATASKAPLVKKIPSGSSIVQAVLRKIYEAKEGLRAALLRHCANGFTSEILELLRDFEQRYTDLMSDLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVS5</accession>
    <name>A0A8G1QVS5_9EURO</name>
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        <submittedName>
            <fullName evidence="7">Fatty acid hydroxylase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_453045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="RAH53519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511441.1">
        <property type="nucleotide sequence ID" value="XM_025660977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVS5"/>
    <dbReference type="GeneID" id="37164379"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="180"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH53519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="349" mass="41050" checksum="1B00C602F4F066D4" modified="2022-01-19" version="1">MSGTHPNPKDSMKSTWRRLDRAEWSVWHWFFEILGVHPSNLDKEVPVHPKTEKVPYMRSWSQHLWILYHALLPLAVHHVYVSYTGHNFTAVGAFILYSVAFKLIAIHQLQVMRRMGHVLGFLDGDQHGRDGVPDVGVAKVVRSLLSTSTFRPIMTVFLSYRVSQAPAQMSWGWLPLEIGLYGIILDFWFYWYHRLMHDVGSLWKYHRTHHLTKHPNPLLTLYADTEQEFFDIAGIPLMTYFSMKLMGMPMGFYEWWICHQYVMFTELAGHSGLRMHASPPSTLDWLLKLIGAELVIEDHDLHHRKGWKKSHNYGKQTRLWDKIFGTCHERIESREENVDYENPVRMPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXK7</accession>
    <name>A0A8G1QXK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_84437</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513334.1">
        <property type="nucleotide sequence ID" value="XM_025665727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXK7"/>
    <dbReference type="GeneID" id="37169129"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF27">
        <property type="entry name" value="CHITIN-BINDING TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH55412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="251" mass="26408" checksum="09CF30E2838FA63F" modified="2022-01-19" version="1">MSTSDIKGYAIRRNNSCLSDEVGCGPTWETWHACCPSGSKCPGKEYSIQNNVCCPTWTDCTSEIKPATCANSSWNMYDYDGYFCCTEDESGFRLKGTDWVGCLSPDSPGNASYSALRLIATTSSTATSAPTSTSASTATASAATTTAASSTGSGSSTNTGAIAGGVVGGVAGVAAIAGLLFYFLRRRNKQRPESQTQMHLQPQDPSPQYSAYAYSQTQQAYSAPVSELDGQSAPVELPSNHAPKAELAEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXT7</accession>
    <name>A0A8G1QXT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipopolysaccharide-modifying enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_451864</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512898.1">
        <property type="nucleotide sequence ID" value="XM_025660690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXT7"/>
    <dbReference type="GeneID" id="37164092"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF104">
        <property type="entry name" value="PROTEIN CAP1, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05595)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="315"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH54976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="609" mass="70460" checksum="5641C96C68AC816E" modified="2022-01-19" version="1">MRTQRFVVWLGTFVLVSLFLIFFRGPSPSPSPIVDLYPSPDSRPPTTLQRPPVPSNAQLIEQSGLRKAAQPDSLHPIASLVNNAEQQFDRLLSRQSKTLAQAVNEYRERYNMHPPPHFDKWFQFAKDRGVQLIDEYDTIYHALLPFWALEPKTIRDRARETLGFDNSMIGVLIRNGSVSLVEGGAFEQSWQRSATAKMIGSFVEYLPDMDLVFNALDEPRVVVPSEDLQRLVAIAREQVSQITVTNTMPTNAWSDRPSDLNKGDRIDEVRTTRFNRFTRQSTWSYSRSSCPVDSPVRSLDEQAADNVNSYAQGELGFIYNTSAFSDICNSPSLRHKYGFFDRPNRFEAVHDLFPVFSQSKISSYQDILYPSPWYWSDQVPYEEDKDMEWNEKSSQMFWRGSTTGGYSRAGGWRRQHRQLFVGNVNALNTAKILSKTESNQWKARGVGRNSFANLFDVRFTYIGQCDDKDCAAQGEYFDLAEPVDQQDAWAYKHLLDMDGNAFSGRFYAFLRSRSLVHKVSIFREWHDEWLKPWTHYVPLSLTGDDYLEAMRYFESEEEGRVIAPRLAQQGREWAQKALRNEDMEVWFFRLLLEYGRLVDDNRHNLGFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXW2</accession>
    <name>A0A8G1QXW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_498325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513840.1">
        <property type="nucleotide sequence ID" value="XM_025664027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXW2"/>
    <dbReference type="GeneID" id="37167429"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH55918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29896" checksum="83DBC05F58BB671A" modified="2022-01-19" version="1">MGKRLSSVFNTRIIKFEVGPSRKEFLLHSGLFRDKAGSWGLEECGDSTSSGHDMVNISEPVEDIFKFVCEYLYTGDYQIFQPRHFVQIPRRRSSLLEGRGISLKDNYFENSASVERASHYFIRRLRSKPDHPLSISWADYSDVLLQHARLHHFAGQRGLEELSDISLYRLLHVLHEFPLHERRVGHVLQLLRLVFQNTPEMSEDIEKLMVDFTTAHIKGLVEVEEFQLLLDELPSLSRRILFNLATLSALEVDSRRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXZ6</accession>
    <name>A0A8G1QXZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DJ-1/PfpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_460868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513686.1">
        <property type="nucleotide sequence ID" value="XM_025661743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXZ6"/>
    <dbReference type="GeneID" id="37165145"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF7">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="65"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="227" mass="24729" checksum="841D987DD4AB267E" modified="2022-01-19" version="1">MSTPFDLRNPGRPVHVGVVLLNTVTEHLDIAPVGFFHNFSTSFIKSLPPFAISDDLRSQALDFVTHWVTEDGATPGSLSGNLKVIPTDSFATCPPLDIVLIGAGQMGYQATTTEKDFLRKCYAECSAFLSVCGASDALLATGILEGKTATGPLSFLPLFREIAPGTNWVEKRWVRDGKMWTTGTLLNGLDMIAAFGREVWGGEGTLVEHVLRTGYFPSRNVNYEDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY71</accession>
    <name>A0A8G1QY71_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Apoptosis inducing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_378507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512701.1">
        <property type="nucleotide sequence ID" value="XM_025656300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QY71"/>
    <dbReference type="GeneID" id="37159702"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF24">
        <property type="entry name" value="NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE AMID-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="419" mass="46423" checksum="091B5044CAB83EE2" modified="2022-01-19" version="1">MPSATSIASFTRQFRVLVVGGSYGGLTAALTLLDLSRGRVARFNSTPDAQPPHRQLPIQITVVDERDGFYHLIGTPRALASENYASKTWTKFEDIPALRSPDIRFLRGSVNSVDCQSKVARILDAHTKETRKEKYDFLIASSGLRRVFPTVPQSLRRDEFVEEAKKHVDDIHNAQDGIVVIGGGAVGVEMATELRLLHPNRKVTLIHSRDRVLSAEPLPAEFQERVGSILREAGVKLIFGQRVLDITAIETEGERRLWKLELADGRTIYAGHVMNAVSKSVPTTSYLPEEALTEEGYVKIRASTQFPKNLPNADSHFAVGDMVSWSGIKRCGAAMHMGYHAAVNAHQLMLSEDSNHKPEFIKLQEVPPVMALSMGKTAVTYTPDSGTKDGEDVHDVMFGEDMGYSICWNYMKMSEPCQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYC1</accession>
    <name>A0A8G1QYC1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SNF7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_450815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514080.1">
        <property type="nucleotide sequence ID" value="XM_025660463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYC1"/>
    <dbReference type="GeneID" id="37163865"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="229" mass="25896" checksum="42E0B0CACF2DBC2D" modified="2022-01-19" version="1">MNIVEWAFGKRMTPAERLRKHQRALDRTQRELDRERVKLENQEKKLVQDIKKSAKNGQIGACKIQAKDLVRTRRYVQKFYQMRTQLQAISLRIQTVRSNEQMMQSMKGATMLLGSMNRQMNLPALQRIAMEFERENDIMDQRQEMMDEAIDEATGLEGEEEEGEDIVKEVLDEIGVDLSQALGETPTDIQKTAVGETRVAQAVGAGGGGGGGANTSDDDLQARLDSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ53</accession>
    <name>A0A8G1QZ53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal recognition particle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_403616</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512747.1">
        <property type="nucleotide sequence ID" value="XM_025657236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ53"/>
    <dbReference type="GeneID" id="37160638"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.30:FF:000003">
        <property type="entry name" value="Signal recognition particle SEC65 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00305">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022938">
        <property type="entry name" value="SRP19_arc-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH54825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="270" mass="29166" checksum="B58C8D071821285C" modified="2022-01-19" version="1">MSRHAQVEEVYDSDPEEVAPSDSSPANFANESILSGAGVPMSGSVPMRPAPEPQREIPKHYQCLYPIYFDKSRSRAEGRKVGSELAVENPLARDIVDAVQMLGLNVGFEPEKLHPKDWANPGRVRVLLKNEDGKLVNSRIKNKHHLYILVAQYLKAHPTTEESPYRLRIRGLPMPEKLPAAPAAPRGWKIGKILPIHSPAYSGGGVSDNPLKDAMAEMQNMQGMPGMPQIPGMPDLAGMMGGMGGMGGMGGSPSAGGSEKKKKDKKKGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZN1</accession>
    <name>A0A8G1QZN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_374486</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514429.1">
        <property type="nucleotide sequence ID" value="XM_025656132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZN1"/>
    <dbReference type="SMR" id="A0A8G1QZN1"/>
    <dbReference type="GeneID" id="37159534"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF37">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034782035" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="398"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH56507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="455" mass="49652" checksum="8DD155448DB713B4" modified="2022-01-19" version="1">MAGNQWLRCVLILALAVLGVQGISLDISSEDSVKNAASTAAYGMMKHYKGNESGEIPGKIPNTWWEGGAMFMTLMQYYHYTGDSTYNQEVIQGMQWQSGDCDYMPANWSSYIGNDDQMFWGLAAMTGAELNFPDSSDGYSWLSLAQGVFNTQVARWDNSTCDGGMRWQIYTYESGYTMKNAISNGGLFQLSARLARYTSNQTYYDWAERIWDWSTTTPLLSNSTWNVADSTSTTNDCSTQGDNQWSYNYGAYLGGAAYMYNYTNGTSTKWMNAVDGLLNRTLNTFFPSSHGGEILTEILCEPTEVCNDNEIIFKGLVSAWLAYTALLVPSTYNRILPKLQGSAQGAAATCTGYGNNTCGVRWWNSTWDGWSGLEEQMSVTSVFSSNMIAFNSSSAPLTSSTGGNSTSNPSAGTDDSSDDKTILSTITTGDRAGAGIVTVAFAGGWIGLMAWLMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R054</accession>
    <name>A0A8G1R054_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UPF0187 domain membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_422796</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514745.1">
        <property type="nucleotide sequence ID" value="XM_025657987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R054"/>
    <dbReference type="GeneID" id="37161389"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH56823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="476" mass="53041" checksum="D6277EE6CE7D94AA" modified="2022-01-19" version="1">MGDEASHDNHLAPSADHDVPTIVPANEPKEPRGRLTPRPSFLENLASSTDRQFMLGRRNSSEIDRYFHGPRDLDRHSKWPIFLRMHGSIMPKMILPLAFVAAWATLITLISRFVHNIGINDILLTVTGFVVSLALSFRSSTAYERWADGRKYWALLNQTARNLARTIWVNTAERAGEEGKEDLLAKLTAMNLILAFAVSLKHKLRFEPDVGYEDLAGLVAHLDTFAKEAHDRQVVQPPKKTPWKSVGEYLGVSFAESNPRKLVKRSKKPLGHLPLEILNHLSAYVDRCIANNTLNVSLHQGQAITALSTLNEVLTGTERVLDTPLPAAYSISIAQIAWIYVLVLPFQLYDFLEWVTIPASVVAAYIILGLAFIGSEIENPFGHDVNDLPLDTYCRQLAVELDIITAMPPPKLDEFGTREDNFVLYPLSTSGYPEWKDRSVEEIRAALRAKVVANYPSAAMSDAATVIGSVRSKQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0E1</accession>
    <name>A0A8G1R0E1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-alanine--D-alanine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_61664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514139.1">
        <property type="nucleotide sequence ID" value="XM_025665535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0E1"/>
    <dbReference type="GeneID" id="37168937"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132:SF23">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="142"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH56217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="375" mass="41081" checksum="49501CD2FACD9603" modified="2022-01-19" version="1">MSLPMTQITRSLHNATTPPVVAVLYQAIEPPIINGARKPRKPGGYQDSGSDIAYTLKNRGVRVVTPVSSPNPKEQEGWCFPDTENGILSAVRQGATHLWANTILFSSHPLQASQSLASAPISVVGQPPTLVESFDDKAYLNDRLRIHGSFTLPRSWLIRNSDNISPILDSIPNYPVVGKPVRGRGSHGVKVCHNRAELEAHLNALLLESPIVMVEEYLTGEEATITVMPPSTENPEYWSLPPITRFNHVDGIVPYNGTVAVTANSRAITETEMQDESYRSAMRQCEQVAKLIGATAPIRIDIRRFSEGSQFAIFDINMKPNMTGPGRPGREDQASLTALAAAAIGWDYGALLHKILNSAQPLDRFRAYTNPFASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R148</accession>
    <name>A0A8G1R148_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IgE-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_520836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514638.1">
        <property type="nucleotide sequence ID" value="XM_025665166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R148"/>
    <dbReference type="GeneID" id="37168568"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052820">
        <property type="entry name" value="PhiA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42047">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42047:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034272414" description="IgE-binding protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="21204" checksum="B1648B8A03679DAC" modified="2022-01-19" version="1">MTFLATFIALLTLLTPVLSATNCSTGAFTVISIRSGSFIQNLPLTAADTNFYLGGTTSTACPEDVAEYDACPPGDETVIDYSNYLSSGYVQEIYVDPTGALKFVEAHTSYMDPGASTSTFCYTPGTSYGKWTYTGFGATGFMACPLDEDEEVNGGAWQVFAAMKNATVPSGNVSDCLQFEALAYPWVSNGSSIAAWQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1T2</accession>
    <name>A0A8G1R1T2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cercosporin toxin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_449088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515910.1">
        <property type="nucleotide sequence ID" value="XM_025660085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1T2"/>
    <dbReference type="GeneID" id="37163487"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="277"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH57988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="403" mass="44785" checksum="225C7FEE09390AE9" modified="2022-01-19" version="1">MSNRVLIAGGGLGGLALAQGLRKHNIPFTVFERDAKQNFRAQGYRLRVMQENLRTLLVPEIWSLFEKTAALDDGLPGVGVRLDALTGEPLPAGSGGPPLGIHGARPYTVDRGTMREVLLQGLGEENVQFGKRFERYELRDDCVVAHFADGSSATGGMLVGADGARSRVRRQLVPWYPFVDTGMRMIYGKTGITGDVEGRLNELARRGMSLAKDLREEAPKTLLFEPMRMPRGDVGGMIKLPEDYLYWVLLVHRDFVGMEDEKVLRLNGEESARLSLELSRDWHPSVRVLLEEQDVEQTSTLRMASVRPDLRAWETDSRVTLLGDAVHVMPPTGGQGVNTALRDAAVLVERIVEAREVGGGDVVARYEEEMRQFARERVGLSWQGGYKAFNLRPLEECESVELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R256</accession>
    <name>A0A8G1R256_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_449285</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Aromatic compound metabolism; naphthalene degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516105.1">
        <property type="nucleotide sequence ID" value="XM_025660133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R256"/>
    <dbReference type="GeneID" id="37163535"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07114">
        <property type="entry name" value="ALDH_DhaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000010">
        <property type="entry name" value="Gamma-aminobutyraldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH58183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="499" mass="53843" checksum="FE1E2908E0FD226D" modified="2022-01-19" version="1">MTAMIPHVSNWVNGTHTTATTPGIPVINPATELPIATIDSTSKETVNQIITLSLKTFNDGSWSRADQSTRFTVLSTAARLLRSRLPEFIELETRQTGRPIREMRAQLARIPEWLEYFASVVRVHEGRVTPFKGPVVNTLTRLPLGVVALITPYNHPLLIAMKKIGAALAGGNVVIVKASELAPLSVLRLGALFKEAGLPDGVLQIISGYGYETGKYLCESPLLAKIDLTGGLATYRAIAPSASANLIPITAELGGKAPVCLFPGVGIEDAVKAALFASFIASGQTCVTGSRLLVHTDIYDEFTALLKKRVEKLRLGNPLDDTTQIGTVISKAAVERCAAFVERAVREGGKVLCGGHATTNPSTGKGYYFEPTVIETRPQTDLECNEVFGPVIALIRCQSEEDVIRIANASSLALGASIWTTDFYQAHRVADKIEAGIVWINGHHLNDPSSPWGGFKQSGMGKENGLEAYESYTKVKSTIINYGVPPVWFDDEPVNARYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R298</accession>
    <name>A0A8G1R298_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_488077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515253.1">
        <property type="nucleotide sequence ID" value="XM_025663503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R298"/>
    <dbReference type="GeneID" id="37166905"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF3">
        <property type="entry name" value="ORSELLINIC ACID_F9775 BIOSYNTHESIS CLUSTER PROTEIN D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="44714" checksum="9C9A9D69B5693B93" modified="2022-01-19" version="1">MDCDYAVGELVNRGSPSSNLPEGNRRQSAQDDGHTYISSFLFDFQIPKRKHSRRYKLRPPYAVLGEGISSALTNYPFEFSALDMELFHNYLSSTSLTLAEDEAGRQLLQTRLPELGYSFNYVLRLLLAFSGFHIAHLRERCPQQISRATKPYVERAEQHFAISLRQLIPSVTELNPNTYHALYAASSFMCFCTLARGPQPGDYLAFSSTGQAQCLTLLHGVRSILQMTERMSTHAGAGPRHHHSAESTTAHHEAQVSPFSEENVAPLGQIRQLLLNELEQSDPRHSTYCKVHEDLVSVFHSLRSPKHHLPRGARFPYIFGWLFRLPGLFVADLHEQRPLSLVLFAFFVVLLKDISCYWFMEGWPEHIMAGIYHHLDEKHRPLIQWPREKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2E3</accession>
    <name>A0A8G1R2E3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_437917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516703.1">
        <property type="nucleotide sequence ID" value="XM_025658646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2E3"/>
    <dbReference type="GeneID" id="37162048"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="156" mass="17386" checksum="244F27473427D893" modified="2022-01-19" version="1">MLSDAISILTPRNIYTRELVLALSHKLETTGPQHHVKVQAHRWGGSSLSCEWSADTGKILRKRDLSKSSFSFSGVMRYSDPQLSRADSLSAMFSAMTLVLGPAFHELYDNSEILSRKDGSSLTDLRPPFPAFRKPLSTWANEIPPGEANEDKLNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2I8</accession>
    <name>A0A8G1R2I8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_294733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515990.1">
        <property type="nucleotide sequence ID" value="XM_025655292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2I8"/>
    <dbReference type="GeneID" id="37158694"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="87" mass="10418" checksum="19F6E9EBF5450903" modified="2022-01-19" version="1">MDGIARRFRNQEMRQIRRWFAQRRDLQALISIHMQRWKAVIIDWGENREERGEGNQAAAGGAAVWTAPKQPRKRYLQRPRKEVTAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3I6</accession>
    <name>A0A8G1R3I6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_437747</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516515.1">
        <property type="nucleotide sequence ID" value="XM_025658638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3I6"/>
    <dbReference type="GeneID" id="37162040"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000092">
        <property type="entry name" value="RNA polymerase II holoenzyme cyclin-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 12" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="13">
        <location>
            <begin position="53"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH58593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="301" mass="34417" checksum="6FD152F61AEABCF4" modified="2022-01-19" version="1">MAANYWASTQRRHWLFTREKLAEIRENFRERDMVAHSQFPLPDQRLLNIYFSQQLIKLGKRMSTRQQALATAQVYVKRFYTKNEIRHTNPYLVVTTAFYLACKMEECPQHIRFVVGEARGLWPEFIAPDVSKLGECEFSLISEMNSQLIVHHPYRTLSELQPELSLTSDEVALAWSVINDHYLTDLPLLYPPHVIAVMAIIVAVVFKPSQTSFHGSAAPLASAMRDGGMNILAALGEKGGNGPPPRIQRLIGWLAESEVDIKAVIECTQELVSLYEVWEQYSEKHCKELLGRMVKSKNLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R422</accession>
    <name>A0A8G1R422_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">V-snare-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_295366</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516029.1">
        <property type="nucleotide sequence ID" value="XM_025655297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R422"/>
    <dbReference type="SMR" id="A0A8G1R422"/>
    <dbReference type="GeneID" id="37158699"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.400:FF:000002">
        <property type="entry name" value="Vesicle transport v-SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="126"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="43"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH58107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="224" mass="25617" checksum="E7DD5C4E045EEBF0" modified="2022-01-19" version="1">MSNPLDTDAGSELFSSYETELKLVQADLNQKLDQIAESSGEQRKSAIRQAERALDEATELLDQMRMEKQNIPSAARSKINTRVRNYATDIDEAKRKLRSLSDDRKALFGDRYTDDPQDEHLEQRQQLLSGTERLERSSARLQESQRIALETEDIGRNTLADLNQQRETIMNARGRLLESEGYVDTSIKTLRGMARRMATNRLITIAIITVLILLIFAVIYSKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R434</accession>
    <name>A0A8G1R434_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_513119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516739.1">
        <property type="nucleotide sequence ID" value="XM_025664687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R434"/>
    <dbReference type="GeneID" id="37168089"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="49"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH58817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="492" mass="55164" checksum="D422BACDD3DE7922" modified="2022-01-19" version="1">MASKISDIDTTTADHLESTEKKDPYAADPGIEIDEATDKRLFWMITRRILVIQIVTYFFQSLDKGILNYASIMGIKDDAHLVGQEYSLLGTILYIGILVGEYPQNLLLQKFPVAKMLSVNVFIWGAIVACSAASTRFGSLMAVRFLLGFFESCIQPAMMLITAMWYKREEQSVLNSIWYCMTGVQLMIGGLLAFGTSQYVGGVIKNWQLLFLALGCATCVWSFFIGFFLPDSPLSAKCYSEEDKKLMVERVRHNETGIENREFKRYQVIETIQDPIVWCCVMLILVANLIIGGLGVFSNLIIEQFGFSLLQTELLNIAQGSWTIIVMVGSAWCSQRFQQTCLTMILWTIPAIVGTIVILVVTPTASNAGGMLIAFYCTQFFLAEGNMIISLITRNTAGQTKKSLTMTFLFVGWAVGNLIAPQIFQSSDAPRYLHGFLAHIVIYAVFIALTVLTRVILMRRNKAKEGESSDVSHELAFQDLTDRENPNFRYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4A4</accession>
    <name>A0A8G1R4A4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_447988</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516920.1">
        <property type="nucleotide sequence ID" value="XM_025659832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4A4"/>
    <dbReference type="GeneID" id="37163234"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="50"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH58998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="201" mass="22001" checksum="A0C4BF86EB471573" modified="2022-01-19" version="1">MPGSLSLFSVNAVLLMSADDGSRIFAKYYSPPHPPAGAAPNSTDYPGANPYPTVKEQKAFEQGLLEKTNKQTSDVILYDNRIVVFKMESDVMLYVVGSADENEVLLYNVVLSLRDALGILFKGATDKRTIVENYDLVALAIDEIIDDGIILETDPVLIASRVSRAPAPDAPNLKSIDLSEQGLMNAWELGKRRLAEGLRQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4K5</accession>
    <name>A0A8G1R4K5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_487960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516076.1">
        <property type="nucleotide sequence ID" value="XM_025663493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4K5"/>
    <dbReference type="GeneID" id="37166895"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="224" mass="25447" checksum="DB8704878038A032" modified="2022-01-19" version="1">MEAADLLPLLEQLDDNIDDLEEALKPILDSSVVETSKKLPVMDKAKFHVLVTYALESLIFSYLRLHGVNAKEHSVFRELTRVKQYFAKITALEAEPEKRTLTLDKQAASRFIKHGLAGNDKIDLARKEQEAKERARAQLKASILAKKAGATSQQSSQNATSNSESESESEELVKPAPKPSGKSSDDKKKRKDKQKRRVSKEEHNENKKERRKKKDELRKTKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R514</accession>
    <name>A0A8G1R514_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GDP-mannose transporter</fullName>
            <shortName evidence="13">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_45140</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasmic vesicle membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514842.1">
        <property type="nucleotide sequence ID" value="XM_025660583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R514"/>
    <dbReference type="GeneID" id="37163985"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH56920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="381" mass="41550" checksum="D1961CF2CB1EDFB2" modified="2022-01-19" version="1">MAEGKKTDDYTIQMDSIDQGNKSFEAPPPPQPRSPPSGSLSNNPILPVLAYCGSSILMTVMNKYVLSGTDFNLNFFLLCIQSLVCIIAIQTCKSCGLITYRDFSADEARKWFPITLLLIGMIYTGSKALQFLSIPVYTIFKNLTIILIAYGEVLWFGGSVTGLTLFSFGLMVLSSIIAAWADIKHAVESNGDATAKMSTLNAGYVWMLVNCLCTSSYVLGMRKRIKLTNFKDFDTMFYNNLLSIPVLIVLSAFLEDWSSTNVNRNFPPVDRNSIVFAMILSGLSTVFISYTSAWCVRVTSSTTYSMVGALNKLPIAISGLIFFDAPVTFPSVSAIVVGFVSGIVYAVAKIKQNAKPRTGVLPTANPPVSASSQSMRDSLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R582</accession>
    <name>A0A8G1R582_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="10">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_512620</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="10"/>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516391.1">
        <property type="nucleotide sequence ID" value="XM_025664666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R582"/>
    <dbReference type="GeneID" id="37168068"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF2">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034503160" description="AA9 family lytic polysaccharide monooxygenase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="12">
        <location>
            <begin position="304"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH58469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="343" mass="36525" checksum="C4A00707433F3085" modified="2022-01-19" version="1">MKYLPLAVAVTASLAPTASAHYIFSKLVLNGEASADWQYIRETTRSICYEPTKFTNTFDNLTPNDNDFRCNLGSFSNAAKTDVAEVAAGDTIGMKLFYDTSIAHPGPGQVFMSKAPTGNVQEYEGDGEWFKIWERTLCNEEGDLTKDAWCTYGMSEFEFQIPAETPAGEYLVRAEHVGLHGAQANEAEFFYSCAQVKVTGSGTGSPSLTYQIPGLYNDSMTLFNGLNLWVDSAEKIQTDILETPIGDDVWNGSGSGSSSAASPSVSSASVASPGTTTAAVHAYVQTPASSSSSSIQSTAASSGNLVSHWGQCGGLGYAGPTECESPCTCVEQNPWYHQCVTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5A0</accession>
    <name>A0A8G1R5A0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_446897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518263.1">
        <property type="nucleotide sequence ID" value="XM_025659608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5A0"/>
    <dbReference type="GeneID" id="37163010"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="366" mass="40817" checksum="0CAC353DDAEC9F2C" modified="2022-01-19" version="1">MSNPSLYGQPRNKKTSQSEAPSASTLAFTSTLSSLIAKDSTTDSSSTRGTGRPRPSKAPKSDLFSRPNKGAQKRAAADLRDDDNAALQQTHQRTQDIGAVDAATLHRSKRRMEEKVRMYEDMSRGLYLAGGESDDDEGDDVGPGDAYLARLRRKEREGLVDFDQKWRKEDGEGDEGEEDDAEDNDDNASIVSYEDELGRSRRGTRAEAARAAALKAEEGEGRGGNTERWRPARPDNLIYGATVQAEAFNPDAVVASRMSDLAARRDRSATPPEEMHYDAEAEVRNRGTGFYAFSKDENVRRKQMEELLNAREETQRERDARRERRAERERLRDERRKKVDELRAKRRAEMFLAGLGDAGLLAGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5M9</accession>
    <name>A0A8G1R5M9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Citrate exporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_510712</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transmembrane transporter that exports citrate across the cell membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>citrate(in) = citrate(out)</text>
            <dbReference type="Rhea" id="RHEA:33183"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517655.1">
        <property type="nucleotide sequence ID" value="XM_025664563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5M9"/>
    <dbReference type="GeneID" id="37167965"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="54"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH59733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="502" mass="54395" checksum="EE3A19408CC83434" modified="2022-01-19" version="1">MMATMKPKEEYCDGPDTKAERTPSDTESPVEDPDPAPGETEVYSTFSRRTRALIVLIASVASVFSSLSANIYLPATDTIADQFHVSDTLINLTLSTYMIFQGLAPTFFGGLADNAGRRPAYILCFIAYIAANIGLALQRNYAALLVLRCLQSAGGSSTIALANAIVADVVTTAERGKYIGYVSAGFIIGPSVGPIIGGLLTQFLGWPFIFWLLAILASAFFIVLVLFLPETARKVVGNGSRSPPIWNLSGLQLCSRRQRAEAHSSAGIHLRFPNPLKALTIIFHKDVFLILLGNGVAIAGYFAVTGTITSQFSRIYGFNEVQIGLCYLPLGVGNLIAAYTQGKITDWNYRRHASSQGIDISSNRRPDLDKFAIERPRAEVVLPQAIGEALSMIAYGWVLHYETNLAGPLVLLLLIGYTSAAVMNTLSALMVDIYPESPAMATAAMNLTRCWLGAGAAAAILPMIDAIGNGWAFTVIGFMCFVCVPAMVVVWLWGYDWRRQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5Y9</accession>
    <name>A0A8G1R5Y9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug resistance protein Fnx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_397429</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="RAH57415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025657022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5Y9"/>
    <dbReference type="GeneID" id="37160424"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="255"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="321"/>
        </location>
    </feature>
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        </location>
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        </location>
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            <end position="421"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
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            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH57415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="564" mass="60066" checksum="FB7E111FAFC13642" modified="2022-01-19" version="1">MAVSASSPDPLDANIDERTPLNSSAQHATPSANTPDYSSITKGLTSDVHSSHGSDEERPLINPPESPGKEVTALTSISTVIGVLLLGEFISNADATLVMAATGRISSEFNRLRDASWLSTAYTLGLCAAQPMYGKLSDIYGRKPLLLWAYFLFGVGCVISGIGPDMATVILGRAISGIGGAGTMAMGSIIITDIVPRRDVAHWRAYINIAMTLGRSAGGPVGGWLTDTIGWRWSFIIQGPLAAVAALLVVWKLKLAHPVTEKSVRRVDFLGTFLLATGIITSTVIMDQAGQSFAWASLSTAILATLSLSAFVAFVLVELYVAPEPIFELRMLRKPNVTPSYLIGSLQITAQVGMMFSVPLYFQVTSKASATVAGGHLVPAVIGNTLGGLIAGAFIRRTGQFKVLLILAGLVASVAYLLLFLRWNGHTGFWESLYIIPGGMGTGFCSAAAFVSMTAFLMPQEVAMATGGYFLLFSFAMTAGVTVTNSLLGTVFKRQMEQHLTGPGAKKIIERALSDTSYINGLQGHVRDVVVKGYVAGLRYTYLFSLILSLLGSVLAWTVRKHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6G6</accession>
    <name>A0A8G1R6G6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_485328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518090.1">
        <property type="nucleotide sequence ID" value="XM_025663321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6G6"/>
    <dbReference type="GeneID" id="37166723"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="95" mass="10546" checksum="7732DB8E80302EE2" modified="2022-01-19" version="1">MAPGVEPPELPEFNPQAKNDSSKTNKEKSVHDVHKEEPQSSSTSGSGSGTFQHISNPPVAVRPDEFDYLHAAPGAFKCALCRQWHTKRCPWLINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6J9</accession>
    <name>A0A8G1R6J9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_228843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518415.1">
        <property type="nucleotide sequence ID" value="XM_025654766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6J9"/>
    <dbReference type="GeneID" id="37158168"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000048">
        <property type="entry name" value="Zn-dependent hydrolase/oxidoreductase family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024884">
        <property type="entry name" value="NAPE-PLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="142"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR038896-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="427" mass="47873" checksum="E5890C591DD70B6C" modified="2022-01-19" version="1">MRTFLRGVFCFRQGSTSAPRLSSPQRRNMTKATSAASTSAALYSLAVVLSPASEGPENVKEKAHHLKNGFQNPWDSWQSPTVGNALRMWGGIITWKIKFPDVTPPTVPVQQPKFLPDRETSGLRATWLGHACYYVEFPNGLRVLFDPVFEDRCSPVSFMGPKRFTEMPCRIEDIPIIDAVVISHNHYDHLSHPTVMEISRRHPNCHFFAPLGNKAWFSSIGIDKMTELDWWDERDIVLSPSHESVTEAGAGEGQSSNQSNITARISCLPSQHTSNRGVFDRSKTLWASWGIEAGGRKLWFAGDTGYRNVPMLPAGTDDHAPEYDLPSCPAFKQIGQFRGPFDLGLIPIGAYSPRWFMSPMHADPDDAVQIFRDTKCKRAMAIHWGTWVLTDEDVLEPPKKLKEALTKYGYPEVGAFDVCDIGESREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7D1</accession>
    <name>A0A8G1R7D1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_418162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516992.1">
        <property type="nucleotide sequence ID" value="XM_025657805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7D1"/>
    <dbReference type="GeneID" id="37161207"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="198" mass="21789" checksum="612340D79BBEFE65" modified="2022-01-19" version="1">MSTSNLPILTKLNGSTSDQVTPVTVEPTRSLTIQTKRRMSIIPPPIDPLEQLVCIICMEESIPPHMLSDIISEAYASDRSLPPGLILLDTSFIHALDSLTPESASVPPVDHMFCSPFVGMGVEQITDVITNICHKSILSTRLFFLADDLTAATETLRKVEVGKTLDWHSSRVPWRDANVMAAKWTRGYASGMITSDCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7D3</accession>
    <name>A0A8G1R7D3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_365068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518786.1">
        <property type="nucleotide sequence ID" value="XM_025655725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7D3"/>
    <dbReference type="GeneID" id="37159127"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF14">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="97"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH60864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="221" mass="25099" checksum="C1C866F6085D0BCC" modified="2022-01-19" version="1">MTKPLLLHAHATGPNPIKIAIALESLKVPYDVQQWEFGDDPKKGVKGEAYLKINENGRLPSLQDPNTGVVAWESGACMNYIRRVYDREGKLGPAGKEEQDVVDLEKWEYFLLTNLAPMLGQVNWFRNYHEVKNQDALDRYSAQVYRCFGVLEGQLKKSNGESILPEKITAVDYHAEPWVRQYTFAGLSLDSYPLLQRWLAGMAKLEEVKRGYVKVKGQGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7N9</accession>
    <name>A0A8G1R7N9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydroorotate dehydrogenase (quinone), mitochondrial</fullName>
            <ecNumber evidence="5">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_393582</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="5"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517696.1">
        <property type="nucleotide sequence ID" value="XM_025656888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7N9"/>
    <dbReference type="GeneID" id="37160290"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106430">
        <property type="term" value="F:dihydroorotate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000242">
        <property type="entry name" value="Dihydroorotate reductase PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="13">
        <location>
            <begin position="153"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH59774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="526" mass="56367" checksum="E008DE000772B2A7" modified="2022-01-19" version="1">MATNAVALAWRSAGRRAPALHSLRATQRPSILHRESLLRQVRYSSDAASQTKEAAKETTAQVTETVKEAPKKTGRKLKRTVWGTSLALTLLAGYIYGTDTRASVHRYGVVPLVRLLFPDAEDAHHFGVDILKTLYKYGLNPRERGDPDSDGALLTEVFGYTLSNPIGISGGLDKHADIPDPLFELGPAIVEVGGTTPLPQEGNPRPRVFRLPSQNAMINRYGLNSKGADHMAAVLEQRVRDYAYAHGFGEHELAEQRVLNGEAGVPPGSLRGGKLLAVQVAKNKLTPDNDIEAIKRDYVYCVDRLAKYADILVVNVSSPNTPGLRDLQATAPLTAILKAVVGAAKSIDRKTKPFVMVKVSPDEDADEQVSGICDAVWGSGVDGVIVGNTTNRRPEPLPKGFTLPPKEQDVLKETGGFSGPQLFDRTVKLVAKYKSLLDASAPTSAAAVPKAIEAAEPDVENVPPTVSEAVEGLPARKVIFASGGVTNGAQARKVLDAGASVAMMYTAITYGGLGTVTRVKEEMKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R877</accession>
    <name>A0A8G1R877_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_445295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519808.1">
        <property type="nucleotide sequence ID" value="XM_025659227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R877"/>
    <dbReference type="GeneID" id="37162629"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="103" mass="11691" checksum="D14A637EEFC83570" modified="2022-01-19" version="1">MSDTTKLLRMLVSNSTTPSESGRCIVVDLNLLESEGDPLFLPVRTRLRPPSQVLSFACLTLVCSALFARWNFGRLDAFELLLPLDTYVCRKRQTTEAKNKKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8G4</accession>
    <name>A0A8G1R8G4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Meiotically up-regulated gene 154 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_250518</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517727.1">
        <property type="nucleotide sequence ID" value="XM_025654926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8G4"/>
    <dbReference type="GeneID" id="37158328"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10332">
        <property type="entry name" value="DUF2418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH59805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="50013" checksum="E6081B425803F706" modified="2022-01-19" version="1">MPRLVRRRPLTERIKSYLNPLDFLLWLSEEIDTHDWDQFEKNWALPLGIALNAVFLIARANSQSYGSQAIDDVFGDDGSTPWLSWFSSFIVHLLTTFTAFNAFYTFYRKRHYRMFEASIDQAPATPSAHRVRVNSTPVTASPLKYLADTIARSAQSRAHPDAQRDVWELAVWDPLPICIRLFCLFSPGHVLVYWVFLPTQLSDPRPSVTIVTTIFIAALLSVQMTFLSSSYTQQAKDSMVVHKEVLREYDTKYVHPRTQPLMRDVATQFSESDPDVKQNKVDTFTPTVVLHRGFKTSPNPNYVSHVDPEGRSSARQSFATTPTGVSHRAAALQTPSHLRDASPIVRNSISAIRQPQFRQTPTTTGDGGSLGIYSHANSPLKKSTSANLERRLQSNGDFFYKERGTSAMRRPSSPLKRSNVPAGSPLTPGPRRGQLDARRDSGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8U1</accession>
    <name>A0A8G1R8U1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_224785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518266.1">
        <property type="nucleotide sequence ID" value="XM_025654734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8U1"/>
    <dbReference type="GeneID" id="37158136"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="134" mass="15127" checksum="748D83EB2F672EC0" modified="2022-01-19" version="1">MAMAVGDNLVDAGKTSPFRRWLTRLYLMGTTSVMIHVHVIFLVDMVKIMHVVCLIRHCFGVRYPSDSLLCQRLELYLGNAEVSTETLNDLFKMLSLLLGRQVLSILLVCNVASFGWLTSGELYITMRSIQGRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9D7</accession>
    <name>A0A8G1R9D7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_485423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518192.1">
        <property type="nucleotide sequence ID" value="XM_025663327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9D7"/>
    <dbReference type="GeneID" id="37166729"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="25"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH60270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="167" mass="19105" checksum="241B31BAE400CBC5" modified="2022-01-19" version="1">MQITSANPLTVRLGNKTWTLRGLSHFLHLPHSEGDTRKDPSGFLYHEQEAELWICLAQQLLNRRTGSILIMSPYRAQVALVDRLWDQRFSELRPRPRIQTVDASQGSEADVIVVLITSISYPPGNSILMAEAVDDRSQKHSWLKQYRPIRGKNDLGLVRRETLTSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9M8</accession>
    <name>A0A8G1R9M8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_443999</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520573.1">
        <property type="nucleotide sequence ID" value="XM_025658919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9M8"/>
    <dbReference type="GeneID" id="37162321"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="5">
        <location>
            <begin position="294"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH62651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="483" mass="53302" checksum="D619A94560373D75" modified="2022-01-19" version="1">MPPPEHSLFQFLAKALQTHHRFLAGRLSRAESPIYVIGNPSADLDSIISAIVYASFAHPRPHVPLINLPTVPAGPELRRLRPEFIKSLWLSTHPPVPDEETWSDTPESAGPLLQEHILTVSDFATHLQDYNHNNNQLTADAVLVDWNALPIRSPTQPRGQGALPTLPNLTFTVLGCIDHHVDEHFLAPITDPDQPFLLQPAGSCTSLVVNMLDKMDRWRRTSSTTSTPAELSSELQLAKLAMSAILIDTANFTAKEKVTDSDTLAYSFLRSKINAISNRDGDAAGKPWDHNKFYEEVVAAKQGSLDLLTVPEVLERDYKEWREVPSSSSSKKKEEGEGEGEGAVKIGICSMVRSLPWLERKAGGTGALLDAVVDYAKREELDVVMVMTAFSGAEGKFCRELLVCATGEGGVRGVEVFEEQAGVQLGLEKWRVLDGDEESKSSELGDVSGDDDQSWRKWIWVQEDVTKSRKQVAPLIREAVKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9Q1</accession>
    <name>A0A8G1R9Q1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_189510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519093.1">
        <property type="nucleotide sequence ID" value="XM_025654422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9Q1"/>
    <dbReference type="GeneID" id="37157824"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH61171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="75" mass="8591" checksum="38DBFBE23C9C6BA5" modified="2022-01-19" version="1">MSNFFPVFLRRMNRGVYIGFNNSPSRRPTAFLPIAFLPVFPLHISTHPEVVFCYSSSFVASLIPVLRPNQLAFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9X2</accession>
    <name>A0A8G1R9X2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="16">HMG-CoA reductase</shortName>
            <ecNumber evidence="16">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_445237</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">HMG-CoA reductase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA). In this module, the cytosolic acetyl-CoA acetyltransferase catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthase then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="16">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="16"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519754.1">
        <property type="nucleotide sequence ID" value="XM_025659212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9X2"/>
    <dbReference type="GeneID" id="37162614"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025583">
        <property type="entry name" value="HMG-CoA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13323">
        <property type="entry name" value="HPIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0521">NADP</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="17">
        <location>
            <begin position="227"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH61832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1071" mass="114766" checksum="5EFAF0223D707877" modified="2022-01-19" version="1">MAGSLISLRSREVQPVSSQTTPSWFKEKITPGLLSLSRLASAHPIHTVAAVALLVSSLYSSLLEDSIFDKTQSVAKADWSSLTAGSRRLYAGPQSDWNWQAEVPNAPISSDVDHSALLTLIFPERTDTFHESPATPLLQLPSNLSVTSLPSTSKSFSTNSNEHIHAFSLPYSQASDFLTMVQEVPNSSPGQWIMKNARAQTQNSLADRAKDAWVSFVDLLKNTQTADIAIMLLGYIFMHMTFASLFFSMYRMGSKFWLATSVLFSSTFAFVLGLFVTVELGVPVNMVLLSEGLPFLVVIVGFERYISLTRAILKHAMDRRSPSVNTQSAIKSVITDKGSEIAKEYAIEIGILVLGALSGVQGGLQQFCFLAAWTLFSDAIFLFTFYTAIVCIKLEVNQIRGYTDMRKALEDDGISSQTAEDVARSSPSKSKTTLFGKSAHVPRFKVLMVGGFLLVNIASMCMVPFRNTHSVKDLARGLGGMGMSPPVDPFKVASHGLDVILDKARSSGQDTIVTVLAPVKYELHYGLPGMGSSDDNGDMTFTLDGYGIGGRVVGGLLKSLDDPVFCKWVIAALVLSVVLNSHLFSAARQGVKNTPEHSTEAEKPVNVVSRNVPCECQRAVVPTSPAAGGELAIKRTPEEMEIMLAEKRAHELTDEEVVELSLRGKIPGYALEKTLKDFTRAVKVRRAVISRTKATADITNALEHSKLPYENYNWSRVFGACCENVVGYMPVPVGFAGPLVIDGRSYFIPMATTEGVLVASASRGSKAINAGGGAVTMLTADGMTRGPCVSFPTLDRAGAAKIWLDSEEGQTTMQKAFNSTTRFGRLQSMTTAIAGTNLYIRFKSTTGDAMGMNMISKGVEYALEVMKSAGFEDMKIITLSGNFCADKKPAAINWIEGRGKSVVAEAIIPGDVVKSVLKSDVDSMVELFVAKNMIGSAMAGSIGGFNAHAANMVAAIFIATGQDPAQVTESANCITIMKNLHGSLQISVSMPSIEVGTLGGGTILEPQSAMLDSLGIRGSHPTEPGANARQLARIIAAATLAAELSLCAALAAGHLVKAHMQHNRAPPSGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAL9</accession>
    <name>A0A8G1RAL9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CT20-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_446409</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519166.1">
        <property type="nucleotide sequence ID" value="XM_025659499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAL9"/>
    <dbReference type="GeneID" id="37162901"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581">
        <property type="entry name" value="MRG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581:SF5">
        <property type="entry name" value="MRG_MORF4L-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH61244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="281" mass="30536" checksum="7696D1386088016E" modified="2022-01-19" version="1">MPPRKKAKLTPQNESAEPSASTTDQPTTADYDPVTDPWTDEQETALLKGIIKWKPVGMHKHFRMIAISEFMKSQGYAPAHAEHTRIPGIWKKLGTLYNLPALDEREDSLITDTAEDSKEFYCPFELPQDEYGELMFERRLAMEGTASPDPSTHAGSRRGSTVADTDEPRSSPAPSRGRKSGRGGRTSGRGTRSSRLQVEVEPPAKGSGAAEEEGDSGEETGANEDGDEDGSDAAKDDSEVDEEAEGGSPTTRSTRAQTSRTKQKGRSAAGTGTRRGRRRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAP6</accession>
    <name>A0A8G1RAP6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_361286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521098.1">
        <property type="nucleotide sequence ID" value="XM_025655586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAP6"/>
    <dbReference type="GeneID" id="37158988"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF31">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH63176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="298" mass="33164" checksum="9AAFF201CC5F06A5" modified="2022-01-19" version="1">MASQNDTNVTFVLYRYTPSIPAAAIFTAVFILLAIVHTYMAFRYRSKYFIPFIIGLLFEAAGYIARIFSHNDPLALGPYIVQTMLILVAPPLFAASIYMTLGRLILYLDAESASLLRVKYIAKIFVVGDIISFLLQCGGGGYMSAGSLSAMEDGAHIVIGGLAVQLLFFGFFIIASAIFHYRVKKNPQYYTTRQVASSSRRDSWECMLWCIYGACVLILIRSIYRVVEFVEGNDGFVMHLEYLLYIFDAVLMALQAMLLLIGYPGRVLGGGRRKDGGVPLEDRADSEERFLRGGKVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAU2</accession>
    <name>A0A8G1RAU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inheritance of peroxisomes protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_444127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for peroxisome inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520710.1">
        <property type="nucleotide sequence ID" value="XM_025658947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAU2"/>
    <dbReference type="GeneID" id="37162349"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005780">
        <property type="term" value="C:extrinsic component of intraperoxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024758">
        <property type="entry name" value="Inp1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12634">
        <property type="entry name" value="Inp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH62788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="542" mass="60106" checksum="260E1E79330BF86F" modified="2022-01-19" version="1">MSDTSDAPLPQTQSLRRSATLPSKLITRPRRQSESLKPSENDLFYHPSAKVVHFAPRALAPIPSSTAPSDFDYPVDTVETLPWRSPTERTVALGPLRLENVHGLTVFLKCGNVVHAILKNSQCWCVDGESTFVLRIRPLTYYRIELPADTDDNKVLVTEMKNVLPRVLRYEMTPCPFKRGFTVEIPEEAKAPRRKRAWRPKGRRESAPISSVYYHGLSKSKEDLTKDPVSAGEDTDGEATDDSGFSTKASNSASNSTILETIPDDNETPEAPQTFEQVDSPKRADPEPEQNFQTLLARFEDKPKQQVDPETTFSSSVESFHSLGPSLSTLPELDACSTPTSTEGTEQFQSDHSDTHSPPEEQPFQETERSRDRLSVYVDCWDDLSSASHDMPGAFHEREIKPIPTKVPDVQRPVAPRTGSTDSNPNLSSMSVEFRRRSKASLEREVSPMPPASSLAVARPEKHDAASLIHKTATLVLVPPIQLLVVLIHIAARIVIGPALESAMGELNRKIEYEVDHAQDTVDDFDLPLPDRSGVSADENSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAV3</accession>
    <name>A0A8G1RAV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_445171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519693.1">
        <property type="nucleotide sequence ID" value="XM_025659193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAV3"/>
    <dbReference type="GeneID" id="37162595"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034953564" evidence="1">
        <location>
            <begin position="26"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="70" mass="7784" checksum="EAF324AEBB478892" modified="2022-01-19" version="1">MCKRVGDSFFLSKSCLLLLLLPVGATVLGAFVGSHRGKGCLWLVVELPRVVGPWERQMMIMMLSYALLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAX6</accession>
    <name>A0A8G1RAX6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BO85DRAFT_446554</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the MRN complex composed of two heterodimers RAD50 and MRE11 associated with a single NBS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 19">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519316.1">
        <property type="nucleotide sequence ID" value="XM_025659534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAX6"/>
    <dbReference type="GeneID" id="37162936"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
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        <property type="term" value="P:meiotic DNA double-strand break formation"/>
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        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
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        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
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        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
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        <property type="term" value="P:telomere maintenance"/>
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        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
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        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
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        <property type="entry name" value="Metallophos"/>
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        <property type="entry name" value="Mre11_DNA_bind"/>
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        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 17 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 17 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 17 19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 17 19" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 17 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 17 19" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 17 19" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 17 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="21">
        <location>
            <begin position="290"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="527"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="570"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
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            <begin position="605"/>
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    </feature>
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        <location>
            <begin position="651"/>
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            <begin position="722"/>
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            <begin position="740"/>
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    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="125"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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            <dbReference type="ARBA" id="ARBA00004286"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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            <dbReference type="SMART" id="SM01347"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="RAH61394.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="793" mass="89118" checksum="7F7E167FC8BE08F5" modified="2022-01-19" version="1">MPRLDDSETIRILVSTDNHVGYNERDPIRGDDSWKSFHEVMCLAKEQDVDMVLLAGDLFHENKPSRKSMYQVMRSIRMNCLGDKPCELEMLSDASENFQGAFNHVNYEDLDINVAIPIFSIHGNHDDPSGEGHLAALDLLQVSGLINYYGRTPESDNIQIKPVLLQKGRTKLALYGMSNVRDERLFRTFRDGKVKFYQPSIQKDDWFNLMSVHQNHYAHTETGYLPENFLPEFLDLVIWGHEHECLINPRLNPETKFHVMQPGSSVATSLVPGESVAKHVAILSITGREFKCEPLRLKSVRPFAMREIILSEEKGAQKLARKDNNRTEVTRLLMEIVEELIEEAKTEWLEMQDDTAEDEELEIPLPLVRLRVETSTPEGGSYDCENPQRFSNRFVGKVANVNDVVQFYRKKKNTNSTRKPGETDLDETAVSHLSTLDTVKVEQLVRDFLSAQSLTILPQNSFGDAVAQFIDKDDKHALEMFVNESLESQMKHLLALDRDNDLEEEEEVAESSLQKAMERYRTQMEDMFSRGIKKRTRGKKRFKPKPDGWDTEFDGVWEDQPGALIHSENEDGDPNEDVAGEDGAEAPTTSRTTSSTRGRGRGRGSRATTTATTATTRKTATTKAAPTTASKKTTTSSASTKTRKRRPVSSNEEDEQEDVIMLDDDDDDDNAAANIDEDEEEDDDDEDSLFVKQPAKPATTRSRRTTKTTSTSQRRKAPSPAPSSNTIGGTAQDTRKTRGKQATQTTLNFVGSQSSVRGTAGSGRSTRATRAASEDIEDDSDAFEPMASSARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAY2</accession>
    <name>A0A8G1RAY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 13">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_393905</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 13"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517842.1">
        <property type="nucleotide sequence ID" value="XM_025656901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAY2"/>
    <dbReference type="GeneID" id="37160303"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH59920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="433" mass="47911" checksum="7427D68CE352ECC2" modified="2022-01-19" version="1">MNGIPEDSAPSSAPLRQPKKRFVGRRTADAQAQKDAPTAQNVETTSIQKATPRRTPRTLNQVPPEILEDPEILAAVELLPRNYSFEIPKTIHRIRTSGAKRVALQFPEGLLIFATTISDILTQFCPGIETLIMGDVTYGACCIDDYTARALGCDLLVHYAHSCLIPVDVTKIKTLYIFVDISIDTTHLIATLERNFQPGKTIATVGTIQFNATLHGLKPVLERAGFKVLIPQIMPLSKGEILGCTSPTLSADEVDILLYLGDGRFHLESAMIHNPAIPAYRYDPYSRTLSRETYVHDEMHTLRRDAINTAKSAKKWGIILGSLGRQGNPNTMAMIERHLNERGIPFVNLLLSEIFPGKLASMADVECWVQIACPRLSIDWGYAFARPLLTPYEALIALGVREGWETENNGVYPMDFYAKEGLGRTKPSQAIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB92</accession>
    <name>A0A8G1RB92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_484996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519182.1">
        <property type="nucleotide sequence ID" value="XM_025663286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB92"/>
    <dbReference type="GeneID" id="37166688"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="127" mass="14246" checksum="B5AB849336448462" modified="2022-01-19" version="1">MEFDQGSRLARVVAEGRATTDGSRSKRGRPERRRLQAPGEAEVLARDAGGGKEAGETAKQRKDAEPKRGVGWFCWRFDREGEGCQENQLRSRKASENDDLTLKRVVKVDRGGDDVGEWMRARISSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBB7</accession>
    <name>A0A8G1RBB7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_361740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520965.1">
        <property type="nucleotide sequence ID" value="XM_025655598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBB7"/>
    <dbReference type="GeneID" id="37159000"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF10">
        <property type="entry name" value="RICH PROTEIN MS8, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="219" mass="23818" checksum="5A74324BF3DED94A" modified="2022-01-19" version="1">MSDSFRQYYYDQYDDPRNCYGQQAAGYSHGDTPGNYSSAQYQQGQRSQYAYNQVLPTNNHYVNPSPGSHPAQDQQSYAPSYDARQSDGHRHEQPTFMRCEQSSSYLPQSQHRQGQNVSYYQTQSEPVPTTDTSEGEKGFVSHEAGVIGRGALSHKLGDGMLGVAGGALAGAAGMNIASKLRKRHRKKHHGKSSRRSSSSSSSSSSSSSSSSSSSSSDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBR3</accession>
    <name>A0A8G1RBR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_444262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520850.1">
        <property type="nucleotide sequence ID" value="XM_025658972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBR3"/>
    <dbReference type="GeneID" id="37162374"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39089" checksum="109394538A52B554" modified="2022-01-19" version="1">MVLLTSSTVSVIISTAVICTFTFLLFLSGYVLQQQSVRSIQHAIRPPPPPPPPAAIPVGAYQGAGQEVFSDSVADKQHKRDDAGSTQATTGNFAYLQLLSTPDPSDICSAILFFKHLATNGTAVQDRLFMYPREWDLMPTKELTEPVATALSLLRTASLEYGIWLLPIDMTLATSEGYKPTDTKLLRLGQIQFMQYDSVLYVQTPGLLLDTAKLDAMLLSRPLPLRHDKNRIESFNNEAWLPMPLRAERDSALPPVYLITVNSVENGHIEARGHVPNTDIPGFSNLVTGPDGVTSPNEDESNPDEQPGYVYFEQDDDGHVKWAHNPLFGSWRVGQHEVCEGLDLDDAVHDGYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCN0</accession>
    <name>A0A8G1RCN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Glutamine synthetase</fullName>
            <ecNumber evidence="5 17">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO85DRAFT_465836</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 17">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15 16">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="5 17"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519917.1">
        <property type="nucleotide sequence ID" value="XM_025662089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCN0"/>
    <dbReference type="GeneID" id="37165491"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019680">
        <property type="entry name" value="Mediator_Med1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10744">
        <property type="entry name" value="Med1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="19">
        <location>
            <begin position="790"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="20">
        <location>
            <begin position="876"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RAH61995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1122" mass="122592" checksum="5FB491D1631CFCE0" modified="2022-01-19" version="1">MATPSSKPNPGATPTHLTSSPRPSGAHMARPISHKSPSTRTPSASGHGHNQPPVSMHQYSTPLAATTGAEDPVTFSSPSALLALGGYSGISPSPAGHDGLVGAGMNENDIQALGMPGLKLGGARDSEEERRRHIDDVVQLLRARVSGRGVCREGIERLSDLEGFESIWQEDSLSIAGNFVDLEIDFHRGYNVVKDVSLKYATPDAQDGEQRDEATAVLKRDLIQSPEEGDRGAWKSLRGFHENLQWLAKHDRLSQEVNCFEAIEGLYESLKRVWEAEWKHRKFAGVYDHLCSGWVGQPCMHKGIRIGLGLDYWVQQARVLDAKEKQKTSSDAMVVDATNGQPSDDEPNSLEGKWSIVVECEEGYPSLRVSKDWVGSEVLTGVNNNDNGPSSSEAHGSDAAVVNWVDPPATLTNNQGHPDAMALDSNMLGSSAPNRRFVAKLEPALDLPILAASDIYRHLGMQLPQEFKMVTYDGLLAPGWSPLSAAGAMGLGPEEASQLERRRRRMSVQSVDATGKPCTKHHSYTFQPFESVAGRTLREIPFAHPRQLADIIPILRQYAFLANLIRSVFSSSYKPDEDKPATPADSSNISFSPPRFTDGNSKKDVIILSNADPNEKRLDALLGSFEKLATSPSAKGKGPVGVGNGNSGSNSTVDDVKVDVTLRTQLGQAPVIMLLFAVDQPDEASESANVEAALTKVSISLEVGLNGRVSVVDMTGLLDDNNNTTTDSMEDTPERKTLELQSKIANVLEISQDIGILVEWILRWSSGEATVISNTENLMKYMSLDQRGTVQAEYIWIDAVGGCRSKTKTLSKPVTSVDELPEWNFDGSSTGQAPGDNSDVYLRPVAIFPDPFRRGDNILVLCETWDSDGTPNKYNHRHEANRLMEIHAKEEWWFGLEQEYTLLGTDGWPYGWPRGGFPGAQGPYYCGVGTGKVYCRDIVEAHYRACLYAGIKISGINAEVMPSQWEYQVGPCDGIEMGDHLWMSRFLLHRVAEEFGVKISFDPKPIKGDWNGAGLHTNVSSASMRAEGGMKVIEAAMKKLEARHVEHIAVYGEGNEERLTGRHETGNIDKFSYGVADRGGSIRIPRQVAKDGKGYFEDRRPASNACPYQITGIIVETLMGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD01</accession>
    <name>A0A8G1RD01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_474695</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520097.1">
        <property type="nucleotide sequence ID" value="XM_025662673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD01"/>
    <dbReference type="GeneID" id="37166075"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="286"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH62175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="398" mass="43691" checksum="B40FECF87474980A" modified="2022-01-19" version="1">MAQSPVAVVCVGMAGSGKTTFMQRINSHLHSKKKVPYVLNLDPAVYSVPFESNIDIRDSINYREVMKQYNLGPNGGILTSLNLFATKVDQIIALLEKRSAPNPSNPSAKPIEHILVDTPGQIEVFVWSASGSILLETLASSFPTVIAYVIDTPRTSSTSTFMSNMLYACSILYKTKLPMILVFNKTDVQDAEFAKEWMSDFDAFQQALREEEESGAFGAEGGAGGFGAGSGYMGSLLNSMSLMLEEFYRHLNVVGVSSMTGDGIDEFFAAVEEKRQEFERDYKPELERKKKEREETKAAQRELELGKLMKDMSVSSSSRQRKDEAETVSEAEEEAEDAAGQGGFDDDDDSDEDGYGGAPPAGNDEGLSQRYKDALADQSAPSDADHSFARYLRKSNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD20</accession>
    <name>A0A8G1RD20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_390738</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518967.1">
        <property type="nucleotide sequence ID" value="XM_025656782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD20"/>
    <dbReference type="GeneID" id="37160184"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000260">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="11">
        <location>
            <begin position="21"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="12">
        <location>
            <begin position="679"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="13">
        <location>
            <begin position="820"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH61045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="955" mass="106451" checksum="4C06D40EE6A804B8" modified="2022-01-19" version="1">MASFLENAYSLVHLDNTADQPSLQELKLQLEKGTDETKMETMRRIITIMLNGDPMPQLLMHIIRFVMPSKSKPLKKLLYFYYEICPKLDANGKLKQEMILVCNGIRNDLQHPNEYVRGNTLRFLCKLREPELIEPLLSSARSCLDHRHAYVRKNAVWAVASIFQHSESLIPDAPELIQAFLDTETDGTCKRNAFAALMSISHQKALEYLASTFDSIPNTDELLQLAELEFIRKDAVQNTQNKARYLRLIFDLLDASTSTVIYEAATSLTALTSNPVAVKAAASKLIELCIKEADNNVKLIVLDRVDQLRIRNEGVLDDLTMEILRVLSSPDIDVRRKALSIALEMVSSKNVEEIVMLLKKELAKTVDEQYEKNSEYRQLLIQSIHNCAIKFSEIAASVVDLLMDFIADFNNNSAVDVISFVKEVVEKFPALRTSIVDRLVSTLSEVRAGKVYRGVLWVVGEYSLEERDIREAWKRIRASLGEIPILASEQRLLDEVPEDAALKEQVNGHSKPSAPTGSRKVLADGTYATESALTSQSAAAARLEAVKAAQKPPLRQLILDGDYYLATVLSSTLTKLVMRHSEVSEDVARTNALRAEAMLIMISIIRVGQSHFVKAPIDEDSVDRVMCCVRSLAEFSQKKELETTFLEDTRKAFRAMVQVEDKKRAAKEAVEKAKTAVQVDDAIPIRQFTKKAALEGAEEIELDLAKATGGDSTVETVSSKLSRVVQLTGFSDPVYAEAYVTVHQFDIVLDVLLVNQTLETLQNLSVEFATLGDLKVVERPTTHNLGPRDFLNVQATVKVSSTDTGVIFGNIVYDGASSTESHVVILSDIHADIMDYIQPAHCTETQFRTMWTEFEWENKVNINSKAKNLREFLKQLMESTNMACLTPEASLKGDCRFLSANLYARSVFGEDALANLSIEKEGEDGPITGFVRIRSRSQGLALSLGSLKGLKASTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD47</accession>
    <name>A0A8G1RD47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_445679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520172.1">
        <property type="nucleotide sequence ID" value="XM_025659326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD47"/>
    <dbReference type="GeneID" id="37162728"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034808309" evidence="1">
        <location>
            <begin position="28"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="71" mass="8101" checksum="62657B00C40F2E5E" modified="2022-01-19" version="1">MGSPTADRNIRSLLRLWIFFLSTLSKGGEQRLPATSVALVWVNSYRVYNRLLMVKIDALPPGKGKVRYSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDP8</accession>
    <name>A0A8G1RDP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_361512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520457.1">
        <property type="nucleotide sequence ID" value="XM_025655591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDP8"/>
    <dbReference type="GeneID" id="37158993"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="53" mass="6624" checksum="1AC7BF54ECB688EC" modified="2022-01-19" version="1" fragment="single">KLNILTYKNLYFIFLIDKIIDCLWNIKIFIKFNTYKDFYYICINPEFENLSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDU6</accession>
    <name>A0A8G1RDU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen2</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_443952</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520532.1">
        <property type="nucleotide sequence ID" value="XM_025658906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDU6"/>
    <dbReference type="GeneID" id="37162308"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000007">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016589">
        <property type="entry name" value="tRNA_splic_SEN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011789">
        <property type="entry name" value="tRNA_splic_SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="7">
        <location>
            <begin position="357"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR011789-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH62610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="493" mass="55263" checksum="1F70BEB44E820634" modified="2022-01-19" version="1">MASNTIPSPASETAAPGKSDSSQKPNAASPARRSRPPRPNYRHIHRFPFPVEVHPLPPLIPHNPLSLVSVLLSYLTYFISPPHQEVYSAYFDSATSSVHVTDPKAIKALWEMGFFGKGTLSRSEPSWLEREKKRRGLLGGMTSEEVTRQRRTERRELKLERARMEKLAIEERLKAEAAARDGTATSNEQSSLSPTPNSGSDGAVSTTEKFSLRKAREAREAKLLESQRSVSQDGIARTPNSAGKRSPSGSKTVRFSPVVQAKEFASDSAILSLPETSADGNVHGGKADEEPELNNEEHLQLSNEEAFFLAYGLGVLRVRDDTRKTEIPTSSLLPLLCRHSYFPPRAPSADLTPDDPFMISYVVYHHFRSLGWVVRSGVKFGVDYILYNRGPVFSHAEFAVVVVPSYGHGYWSETAERKAQCEEKTARSWWWLHCVNRVQAQVKKSLVVCYVEVPPPTSYELDTPSEEDIGSMLSRYQVREMVIRRWVPNRTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RE97</accession>
    <name>A0A8G1RE97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_114550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519612.1">
        <property type="nucleotide sequence ID" value="XM_025653861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RE97"/>
    <dbReference type="GeneID" id="37157263"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="474" mass="54428" checksum="4BD06646991EC9A8" modified="2022-01-19" version="1">MQLRRREQVDLYWSSRHWNPPSRYPTIPKRAVFIPELSPSRSHRESPPVQPTSEAKQDNSSSSSLFSPIVLKFEELKALHSLSRLSWADTSSRRDAEHLAFPPAPIELILHRLQPLKDIHIATEKAFLRGNTSNSRGDTPPIPSMFSKGQRDWREIRLLDTKLDLEREWSMYMEGAKNVICPYCRCDLSSSVAMNREKWRPRWRCAARAHGVLVFWEKSEYEEHMRRKHKSTQPQLAILAERSSRPSGPVFQSCPLCGEGNRADLEEHIADHLTYLALMSIPLPNKSQSTDDHMEMAANLSTDQLRAGGAGRTDSYHSFDESEMEKPGDPSKLPEFPFAGFKHSKQKNTKGKAPLKERILGELHESENAGFFPGRCKWMGCTESQIFEGEEELFRHILARHGKHYFCCLVKGCDKTFADRRELQKHLGTDHNYGLIKEHVIMDVPTHCQWAGCTTKDSFTITGSLYQHIRNMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1REL0</accession>
    <name>A0A8G1REL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit trm61</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 13">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_444317</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer; composed of two copies of TRM6 and two copies of TRM61.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520907.1">
        <property type="nucleotide sequence ID" value="XM_025658989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1REL0"/>
    <dbReference type="GeneID" id="37162391"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000189">
        <property type="entry name" value="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="15">
        <location>
            <begin position="121"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="66"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="371"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="448"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH62985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="511" mass="57771" checksum="5757903065919C28" modified="2022-01-19" version="1">MPSPFLTPGSHSRLDQLALLHLRRDQAIPTVLRLQDDQDAGYKEGKVETTRFGSFPHTTLVDQPWGAQIGASKVDTGSRRGRGPQKKNQKLKRKVDEIDSATPVEGDNTSSPKAAVAASSGFLHLVYPTPELWTTSLPHRTQVVYTPDYSYILHRLRARPGSTVIEAGAGSGSFTHAAVRAAFNGYPTDDSPATKKRRLGKVCSFEYHEQRAEKVRQELHEHGLDGLVEVTHRDVYKDGFLLGDPKTGKSPKANAIFLDLPAPWLALKHLVRHPADGGESPLDPDSPVYLCTFSPCLEQVQRTISTLRQLSWLSISMVEVNHHRIEVKREKTGLEYERVRGAVVFPKDVDEAVTKMRQVEEHSRKYREMMHQLDDEENGTPAAKPEIKKEQEAKTEEEETSAQQPTSTIPPYKQGRLVHRSEQDLKTHTSYLVFAVLPRDWTEEDEQKCREKWPSHQVDLTQPEKPKGRKQLKRERKEREEEEQKKQQQQPQGELTAPVAQEQSAAPVQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RFI8</accession>
    <name>A0A8G1RFI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_133194</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520287.1">
        <property type="nucleotide sequence ID" value="XM_025654006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RFI8"/>
    <dbReference type="GeneID" id="37157408"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000417">
        <property type="entry name" value="Glucose 1-dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH62365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="274" mass="28756" checksum="E8750E93D9F51A75" modified="2022-01-19" version="1">MPLPQILVGKVAAITGGLTGIGRAIALEYLRHGAKVAVNHLGGPKEEPLIEAMRKDVSEIIRSNSNSDSEQSSRFILVAGDVTQPETGRDFVSKAVEAFGRLDVFVSNAGVCKFEEFLEVDPPLLGHTINTNLSGAFWATQAAARQMALAQSPPGGSIIGISSISALVGGGQQTHYTPTKAGVLSLMQSCAVALGKYGIRCNALLPGTIRTQLNDEDMSDPVKRSYMEGRIPLGRLGQPPDLAGPAVFLASEELSGYVTGAQILVDGGAFVNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VI47</accession>
    <name>A0A8G1VI47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_380362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511913.1">
        <property type="nucleotide sequence ID" value="XM_025656377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VI47"/>
    <dbReference type="GeneID" id="37159779"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="20"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="475" mass="54014" checksum="536D3F5A4D1F3C90" modified="2022-01-19" version="1">MPHSTVDQTSSVEAPYSGPRKLVLCLDGTGNQFMGFERDSNIVKIYQMLEKNTPGQFHYYQPGIGTYVEGQSSSSGLLRYPRKLQSHIITTIDQGVGTTFESHVLAAYRFIMRYYSPGDHIYIFGFSRGAYTARFLAEMIHELGLLSQGNEEMIHFAWETFSNFQQARGKTDRTAKDEALISYMKKFNTTFCRPQVQIHFLGLFDCVNSVGQFEIPFHRKSHQYLVSPAARHIRHAVSIHERRLKFKPALVLLEKTKPVDLKEVWFAGNHGDVGGGWSLAPGQFHLLSDTPLNWMLQEVLHLEKSESKLSFHTLNVADVVERENAFPGKEEPGTTAYDVRKRTNQPHDMLMFNRGATFLMVIFWWILEILPLFTRLELEHGKWVPRQWPPNMGAPRDIPEDAVIHPSVHEMVRAGILDPKSIPPRGGNNSHLPSTARITGAWKAMRKSQGKQISSLLQNKKPVGALRKEFDGKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIS8</accession>
    <name>A0A8G1VIS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF218 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_452807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511882.1">
        <property type="nucleotide sequence ID" value="XM_025660910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIS8"/>
    <dbReference type="GeneID" id="37164312"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3620.10">
        <property type="entry name" value="YdcF like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051599">
        <property type="entry name" value="Cell_Envelope_Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336:SF20">
        <property type="entry name" value="DUF218 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336">
        <property type="entry name" value="INNER MEMBRANE PROTEIN, PROBABLE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="122"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="272" mass="29891" checksum="A0EBC3AFAAA7B25F" modified="2022-01-19" version="1">MSSPAINPDDINLLAQFLAHEQIPASSHPPINTDCIVICVSAVLYPAEAVFKHLERNPQSTKTLVLCGGIGHSTPHLYEAVSRHPDYAHLVPEITGKPESHVLHTIFTRCFDATFIQKSGCTVLLEDKSTNCGQNALETRALLARNGIPEPKSMIVVQDPTMTRRTVASFEKAYAPSPPNLLSWPIIVPRVKVEEGELVYDDDGSMPGVTGTLWSMSRFLGLVLGEIPRLRDDEHGYGPMGKGFIGHVDIPKEVEHAYNRVQRGIGEDLAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJE9</accession>
    <name>A0A8G1VJE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_522207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513278.1">
        <property type="nucleotide sequence ID" value="XM_025665243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJE9"/>
    <dbReference type="GeneID" id="37168645"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034998117" evidence="1">
        <location>
            <begin position="21"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="153" mass="17174" checksum="088ECD2CFEB75DBC" modified="2022-01-19" version="1">MRTALSALAVLLTLASSARAAPVAAPSEVEERDASAVLNTRFVTYEDGINKRDEVEERDPTAVLNSRFITYEDAINKRDDVEERDASAVLNTRFITYEDAISKRDEVEERDPSAVLNSRFITYEDSVSKRDEVEERDPSAVLNSCFITYEDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK13</accession>
    <name>A0A8G1VK13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_62765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514161.1">
        <property type="nucleotide sequence ID" value="XM_025665540.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37168942"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000125">
        <property type="entry name" value="Kinesin class 4 (Chromokinesin group)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="50"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="891"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1239"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1574"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="672"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1071"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1642"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="918"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="937"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1239"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1250"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1584"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1600"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1618"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="137"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH56239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1751" mass="194939" checksum="0AD17E2E6CEBEF3E" modified="2022-01-19" version="1">MTGSQPESPADAPQRPFSGIMRTPRSTSRLSMSSRHGGGSRASDEDGKTAVKVAVRVRPPLKPTDPGYELVPQRFQRPMVHVTNPTSVAIDVPQGRKLFVFDRVFAETVDQDGVWDYLSDSVGSFLQGYNVSILAYGQSGAGKSYTMGTSGPSEQSDPKSMGIIPRAAQLLFEKLEGPTKPNRNSGTGLRTPSRYSVGSASSFGKASVEKNWQLKATYVEIYNEQLRDLLVPESTHQGERGTVTIREDAKGRIILTGLHQVNINSYEDLMGALSFGSSIRQTDSTAINAKSSRSHAVFSLNLVQRKASNGVMSPTPKEKRMSMPVEMMSGSDASVMVDSKLHFVDLAGSERLKNTGASGERAKEGISINAGLAALGKVISQLSSRQAGAHVSYRDSKLTRLLQDSLGGNAYTYMIACVNPAEFHLSETVNTVQYAQRARAIQSKPRIQQIADESDKHAVIERLKAEVAFLRQQLRNAEENGRRSAAPQDRAERQNEREVELQNQLLDTQESYNALSQRHAKLISEIARDSEHAGETDPNDVVSLVGKTSVERLKRSQSFAESIEQVVLEYEKTIQSLESSLSNTRSSLSVTESTLLERETKCAYVETVNSQLQARIQKLLDRENSTETYLHELEARLDGQSTGEEKQAAIVAELRKELSRARESEANCEDYISTLEERLAEADQDMELMQREMERLEHVIERQRSLGKLDNLLYELDHVQQNGNQKDLSEDELETHTPVPVKGAYKPRTRATSLSLDVLTEAVETAIPESDEGLTEPTPEAVREASMETEATVETDETNLKVLESATDRLEAQENGARASRASTPTQTKVVADKLETVTQELFDLRMQHESTVSEYETLEAKYAEAMKALAEFQRDAADEARHPDEKVQELLSTNVESRPVSFLEEGKAPSSNDGKQPSSSPSVSSELSLAGEPASSHEQSTLSNGEVPQENHVDTREIDEAKAQEVEQMRRLLVEHQEGVSIMTQKYAQLQSEHEGTLSLIETLKAELQRKNSSPPTTPGFKSPVIRRKTSQSLIGTVDRAHRSLAALRNIAVEEFEARPDTMQNFEVHLDSAMHELHNRMERIQALEAENQSVKKEMETKSTIISGLTRERSSLQGGGGSSVDMGLVNQLRDQVVQQENLINEMKESHDTREKQLLAEIEELKSLLKTQEEAAKAQDVCAEEQDRKISSLEGEVTELKSKHQNAVESLQSSEQELSATLAELDKALASIDAMRSEQAAAGEASASKDAAARELESEREQQEELVAKLKHVIDEHKATTDAHLEKIASLEKSHSEAQLQLSELRTAKDNDSSEVQVHQSRVSELEKEIDTHKSLADSYKRELESLQESHKQEVTELEARATAAAQVDYESRFATMSAEHEETMKTLKSEILESREELTKLLNMVSKLLNADVTAETMAEQIQEIMAQKQHFSDKYAEMLDTNEDLRKQLETKGSDDGRLEELMQSNSTKEAKVNELALLVATLEDTLRQKEEQVKKKEAIIAEVKAEKEKSVRLVEELEEQITNSFDQHHNRLSVIQQERDQALEDAKVKIAAYEKDIETYRVRIEQLELQIKNQDSSHDRSSSITSNLRKSSSATSLPSPPPAIPLPPLPNIASATNGTGSISPPSSRHTSKELVNPQIVDDQEARIRTIEKHLNAEKQLTATLEEALGDLEAQSNKVKSDCDAWKKKARELEEELTTLRKERASQRLSLQAVEEERNARREAEAARAQLEERMNALNKKKKKSTLNCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK47</accession>
    <name>A0A8G1VK47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_450391</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514281.1">
        <property type="nucleotide sequence ID" value="XM_025660365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK47"/>
    <dbReference type="GeneID" id="37163767"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.320:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH56359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="247" mass="28051" checksum="D468516E96C9BAE8" modified="2022-01-19" version="1">MLPSTAPYQLLRPSSNRAALRRLQLQHIGLLPRSSTTTTTTGTTASSLFLRKYATTQDAAPKRRNVTVLSDDGRYEWGELSGREKVARATQQSVNFVVIIAGAVLTGGVFYLLFTEVFSPNSKTWQFEKAVERIKDDARCTDLLGDRREIKAYGENTWSRWARNRPIATSVYQDRLGREHLKMNFHVEGPLNSGTVFVHMMKPLNEHHWEYQLLALEVPGHSRVVLEEAREKPGVGQALKIFGIKWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKN8</accession>
    <name>A0A8G1VKN8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPIN90/Ldb17 leucine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_479360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513817.1">
        <property type="nucleotide sequence ID" value="XM_025662947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKN8"/>
    <dbReference type="GeneID" id="37166349"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN90/Ldb17 leucine-rich" evidence="2">
        <location>
            <begin position="188"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="614"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="724" mass="81547" checksum="2380E86E9101EBBB" modified="2022-01-19" version="1">MDFEVSLENEQQFWDEIQEIVSSPCSSEDHIDNALRSYLGLATKYKDEYLQSELDVTRCSYKLLASNIFVAHTDYVRRQMVYGLLQDDDPATLHLIVSFLLFDGRQHDVAFRMMNEEGLFPRLLELLQARNRKEEEEVPAELHRLLMDLMYEMSRIQRVKIEDLVLVDDEFVKGLFDIIESLSYDVNDPYHYPVIRVLLVLNEQFMISAHDPVDENTSNGLTNKIIKILAMHGNLYKTFGENIILLINREAETSLQLLTLKLLYLIFTTPTTYEYFFTNDLHVLVDILIRNLLDLPEEASALRHTYLRVLYPLLAHTQLKYPPFYKREELKRVLRLLVHGQLSESGPDREKIMHFDEVDETTRRLVLRCAAVEWLRDPEPEKPVHDENTTPTDSVPPDAEFGEPLESSRTLSPTSTVDSSPENMSPTRLDGPDSNASSTAAHHRLNQAQRIGMHLEHASSSSLSVQEVASQHVKPGIITPSRNDTRAAIDSPTSPSKLLGKPKVKPLPPRARRWRGRRDDEHGQTDKIPEDAESQHTSPIIPPATLVTTNSASERTNSTGIVPPPVPSHSRRSASNPPPAVPPPRRSTVPHLHAGHGGVGHLPVPVTSHCTPLASPSRPAQQQQQQHHHSVSSTSTLTTAPSPTPPAATPVTQKHTQKPEPPQTRRRGRTKNGRADLTYKPPPVPDLPAEHLEKTQQQHSHTNSEPKTNATVSVEEAVQNVSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKN9</accession>
    <name>A0A8G1VKN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxo-5-alpha-steroid 4-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_469081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH56974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514896.1">
        <property type="nucleotide sequence ID" value="XM_025662311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKN9"/>
    <dbReference type="GeneID" id="37165713"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF43">
        <property type="entry name" value="STEROID 5-ALPHA-REDUCTASE DET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="376" mass="41099" checksum="D7F8FB22E1F3A74F" modified="2022-01-19" version="1">MGSALSILNHLPPWEHLIHPTPEIYTHFLNIFQYFPLVSLVQWLTSYHPAGKTSLKSSPLNLPGRWAWCIMEIVSPMTLLYLLYTLPKHYPNLTLSPSLSTLPTGNKFLAFLFTLHYTNRAIISPFFAAPSISPIHVIIASSAVAFNWFNAVCLAGWLVGYPVPYSTSSSSYSYASGDDGGSIGRTWLAPLGLTLFLGGMAGNISAERTLFRLRREEAHRKKPSPSITSSSTTKDATKGGGKKKGGNIYSKIYTIPPPTGLFTSILYPHYVAEWVEWLGFAILAAGIVTTPSVEVGGSGAGAAGDGPFQLAPWLVPVARIADWMGVPMPLPAMVFLVNAVSNMLPHARWGRKWYVEKFGEGRVKGRGAVVPFFSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN67</accession>
    <name>A0A8G1VN67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein family domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_49269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514330.1">
        <property type="nucleotide sequence ID" value="XM_025663790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN67"/>
    <dbReference type="GeneID" id="37167192"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="122"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="437" mass="47407" checksum="57B697DE47D9E334" modified="2022-01-19" version="1">MSFPSLDGNEPLPGRPRTASTTRASRGDSRRKSISFNIGGSESLPPSRSASVSDRRRSPSQVPTEREARPATAAVSRGPSPPPPKTYERGVSFDTFDNPDAADFSLTLNYKHKGYQSTRRSRTFLCGTDQNDYSDFALEWLIDELVDDGDEIVCLRAVEKDSSIASDAAVEAGKYRKEAEKLFEQVIQKNTQNEKAISLVLELAVGKVQDIIQRMIRIYEPAILIVGTRGRNLGGMQGLLPGSVSKYCLQQSPIPVIVVRPTTKREKKKKKRLADPSRRNYNNILEMSERRGSHIFDRSSSRDSSVSKLPDEEAAVAAALGLPSTYTHSRSSLSTSERSSVSHDESPSPLGSPDAASRSPLGGSVENSEIDTGSDDEPTVSHVENHSDGTLSPKQASETQEVPGLSEVDAGAFTSSMNVPLIVTEDSPPGGTEKQND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNF1</accession>
    <name>A0A8G1VNF1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_417144</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517658.1">
        <property type="nucleotide sequence ID" value="XM_025657762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNF1"/>
    <dbReference type="GeneID" id="37161164"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="99"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH59736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="482" mass="54546" checksum="E5BA39176ED4C2B1" modified="2022-01-19" version="1">MTRYSMLRISRVIPNPPKWPLLRHQLPIHRVKRPTPIHFTRHTASYATNPKPQYQLSQYNLNHEPYPKYNWIDGPESLEKYRSGGYHPVMIGDLLHDRYRIVDKLGYGGYSTVWLARDTHLERYVAVKVGIANSLPHETKILRALSAPASVPSSVRAGLDSIPVPLDEFEVTGPNGTHPCYTMTPARCNLRDVSFSRLFPLDVARAVSGGLILAVAYMHSQGYVHGDIHLRNILVKLPASFDSLSTEEFYEQYGNPETVPITQRDGGSLPPHVPPKAVLPLYLGKKAEEFTLQDAQVLLSDFGEAFSPVSSPRSGEYCHTPVPYCPPEALFEPQAPLSYPADVWSLATAVWEILGMKAIFSTEAPEDEVTCQQIDVLGPMPQAWYSAWQERSYFFEEDGRPVEGREVWPTLDLAFEQGVREYRRQGGVGDFGDDETAAILELMRGMLRFKPEERLTIEEVLQSEWVSKWVMPDYERGLQAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNL3</accession>
    <name>A0A8G1VNL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_369246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516832.1">
        <property type="nucleotide sequence ID" value="XM_025655911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNL3"/>
    <dbReference type="GeneID" id="37159313"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="297" mass="33660" checksum="929228965752D4A0" modified="2022-01-19" version="1">MDNDKAEEALETLEQTCSILWNAKTGTVPTEVLARLPLSLVSLDHQSVTSGLNVRYFIPWKEGDLRRYERNLAPVEGNERISCEENILLNGCPIGYRLSRPWGSGGEWAETMCSRLLTEVDIAPRKGTQGDMLALKSVTGWRHHIGIPDEPPIPQPWYIQRESYQWGPYCYWTLRGNKHPHVKASMFHGVDGTDGMVLREEIMVIILVMISRLENKDFRKHAVVPVMLFSFMRNRRGRILFAHCLGNRLVIEMSPLCPFEVEGEGWNDSLALFTRYQAAVPSSTDTTKFPVGPDGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNS5</accession>
    <name>A0A8G1VNS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Bifunctional purine biosynthesis protein Ade16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_449742</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514930.1">
        <property type="nucleotide sequence ID" value="XM_025660220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNS5"/>
    <dbReference type="GeneID" id="37163622"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH57008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="595" mass="65015" checksum="0CB8F2C831021C13" modified="2022-01-19" version="1">MSQQKSAILSVYDKTGLLDLAKGLVKHNVRLLASGGTARLIREAGFPVEDVSAITHAPEMLGGRVKTLHPAVHGGILARDIESDEKDLADQNIAKVDFVVCNLYPFKETVNKVNVTIEEAVEEIDIGGVTLLRAAAKNHSRVTILSDPQDYPEFLKELEAGEITDASRKSYALKAFEHTADYDTAISGFFRKQYAGNGEQYMALRYGTNPHQKPASAFMTQGKLPFKALNGAPGYVNLLDALNAWALVKELKQALALPAAASFKHVSPAGAAVGVPLSEKERKVYMVDDIAGIESSGLAQAYARARGADRMSSFGDILALSDVVDVPTAKIISREVSDGVIAAGYTPEALQILSKKKGGKYLVLQMDENYVPAAEETRTLYGVQLTQHRNDIVITPQKTFNTVITPKDLKALPESALRDLTVATIALKYTQSNSVCYALNGQIVGLGAGQQSRIHCTRLAGDKADNWWMRFHDRVLNIKWKQGTKRPDKSNAIDLLCSGQTPRTDAEKAEYERVFEEVPAPFTQEERDAWLKNLGDVVVSSDAFFPFIDNVFRAARSGVKYIAAPSGSQNDSAVFETSEKLGIVFVEQGTRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP65</accession>
    <name>A0A8G1VP65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_447026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518393.1">
        <property type="nucleotide sequence ID" value="XM_025659629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP65"/>
    <dbReference type="GeneID" id="37163031"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH60471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="72" mass="8105" checksum="33C376FF77EC5798" modified="2022-01-19" version="1">MALLATQNVSKFGTINRFLSCLDCDFHDPGRIKARGSPFWEFDGASLCVQFNCLLLEGVFSIYDSWSTSIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPD1</accession>
    <name>A0A8G1VPD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_506345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518781.1">
        <property type="nucleotide sequence ID" value="XM_025664368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPD1"/>
    <dbReference type="GeneID" id="37167770"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034202409" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="14949" checksum="D84D57D9DF6EE3D6" modified="2022-01-19" version="1">MQLKLNLIYLLTLTLASLSAASPAAETGAAAAAAGTDSGAQPPAPTSTGSSSSDSSSSPYQQCAKNILDACLSQMKPQMDKCSQNDWSCLCTQSKNMLTCYNDCPSDPNHTSADQQKMEYCNAAEANSLYSTSTRVTSSRTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPU1</accession>
    <name>A0A8G1VPU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_466486</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
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        <property type="nucleotide sequence ID" value="XM_025662130.1"/>
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    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH61161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="284" mass="30799" checksum="E5D6291E94C6B511" modified="2022-01-19" version="1">MRTEPYQTWLITGASGLGKAIAAAALTANHRVIGTTRDIDKAETSYPEFASNGGIWVCLNPAQHDAYERFSRVAVEYNVDVLVNSAGYAFIGAVEDTSEEEVRAQMEVNFYGPLRAARACVPIMREKGSGHIILISSGAGFIARPARSTYAASKFAIEAIYESLSQEVKPFDIKVLIVEPGAFRTPFPGRQVFPSGPGLENGYSNMMALSKDMDAATKWIKGDPEKAARALVVAVDNGYAGYGFLRMPLGRDCVRVLEEKIAALQADLEATRKVAMGTDVDFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPY8</accession>
    <name>A0A8G1VPY8_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_298213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516130.1">
        <property type="nucleotide sequence ID" value="XM_025655321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPY8"/>
    <dbReference type="GeneID" id="37158723"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="281" mass="28656" checksum="A58159EEA55877D3" modified="2022-01-19" version="1">MTTPTLINLPPPPSDPVTPSDMGPGTPNSGTTSLSALSTTAIKDGHQGQPLPHGRHAHHSHSASATSTTTLEAERADRISRLAGLERVATARAGGTPQPSGMMAGTQYPGYFDSGSGIKERSTVGSASATGSVGARTTWASGSDAFDADRMSEYPEDGTSSVGNYSDEGDASLVAFGEGASTISGPTSHPLLNRTSSGHRPASLGSPGVSRASAFASHHQQHSGEGAMLLSTQSPTGSVTPEPTQDARMVDGMTFDSDVIDTTVRTPRLATPAQGGEQPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQF4</accession>
    <name>A0A8G1VQF4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_456066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519921.1">
        <property type="nucleotide sequence ID" value="XM_025661425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQF4"/>
    <dbReference type="GeneID" id="37164827"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1185"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
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        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
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        <location>
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            <end position="637"/>
        </location>
    </feature>
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        <location>
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            <end position="699"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="731"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="866"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="898"/>
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        </location>
    </feature>
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        <location>
            <begin position="911"/>
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        </location>
    </feature>
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        <location>
            <begin position="1008"/>
            <end position="1022"/>
        </location>
    </feature>
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        <location>
            <begin position="1058"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1098"/>
        </location>
    </feature>
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        <location>
            <begin position="1099"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1222" mass="131422" checksum="11780C7A47DC3A2A" modified="2022-01-19" version="1">MQHTKGLESHELGRTISRSRSTSMSSDSQLSRSHFLAPPPVIPAPSYIASSAASQIITADQEFNAADFVADDEGHESSASALVTREALSSLNAFLDNILFNILAAAKSTQLVKIRPAVAEVLKPRLAKEMVSAADDELSEYLGGPEDEQLEFRSGQTSIGEFDLVRSWKLTRLRCMVYTRLGDMEEDDEEEYINQEIIGEDGGGLRRLASHVGHITPAASIFLTSIIEHMGEQALIIAGEIARSRLSANLEDGDDMTETGANRASMDRLVVEDHDMERLALNPTLGRLWRTWRKRMRGNNLSRAVSRESLVNRQSLVFGPSSRKSSAITIDEISPRTASSRSVNEPLPESQDEVDPASVPLPMSEHDVQEIETAGFLPELDTSDIQTMQAVVAHKVRPHSLMVLTLPSPRSPSSSGNSPITPRLVNIKSPRHARSRSLPNAAPTDEQPSEVEQPAERTSPTPSEERRRLETMYEHDEDDERHGGAATKSETAEQNEPVVPSAAQGAAATPSTSVASVVATSDASSTPVSSPSLTDREIQETDEVGNHETDEKAQVASGVEIAPGPVAPQTQGVVDSTPAQPVAADQDASKAADCDQSTPDDLTPPTVPSSADDIAVEKASRPVSTSGESAISESSRSLPGKRGSFVPGVQHQYGRSSPGIASVSSGVERAAVQRLPARPSTSVASSVYSKSRRSGSFSSSREKRPVTAGSTTSQVSSKLKGLIGRPADTGSLRLRTSSEVSRVSTRESAYDDTSGLDELIRSEETIHFTLTPKSMREMELPDSPRWRAQQAGTDPTDLPKSVEPTPDDMSRSRHSTASSKSTVDLPPVPKFIQPKPKSIEIPAMVLQQKPAAGQARDAKHSMESTRDFANFLKSTGPNTPTTPATVDGSPAKSSRLRRLSDATEISKKLSRPASSTVSVAASSRSGPRMEARSAVVPRGDQSSDLIDFIREGPPTAGAHRIPRTVAPFRDTMDSDELQAIEPGRTKGAPSVASTQSVAETSLVSVGSRTGLLESTSRTSTPTVMAKETKTTFAAPVSVSDDHRPPRTRRRVPDPYAIDLDDDDELDELLEEPKPKRDEESLIDFLRNVPPPEPTPPQQPLAANANSRRGSASVKARLRRNTASEKTLMAKPSKTSLRQQPDNYMGGASNYTVKVGMERNAGAMNGAYDLKTPSVRQTETSALADFLKNTGPPEPPVSKAPAATKSKDSGFARLFVRRKKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQH6</accession>
    <name>A0A8G1VQH6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_485887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518679.1">
        <property type="nucleotide sequence ID" value="XM_025663346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQH6"/>
    <dbReference type="GeneID" id="37166748"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="504" mass="55354" checksum="1DA4780B778127C1" modified="2022-01-19" version="1">MSHPINKFQPFPNFYVYRPGYMVVPLIPLDELPSWVQVGDFDWGDSSLYEAMLPASFNCFPRIGEYDVICHHCYKNVDSYHRSVSERSDSNASSRASDLPKGLAAQLPANSILLDPSFKLEQPPFGASLNVSPFVGLCFSPRKRLCELLCPCLRCTQNGQDQRNDQNQQNDQNQQSDQNQQSDQNQQSDQNQQNEQHEEHEEHEEQFEREDQSEHEGQSEHEEQHPPSHQNTPPPTDPSGHPPPPNTPENPPVNNPADSPNPPANPPLNLPPESPDHSNPSLPEEEGIPLETMSHSDQGHRASQASQAAQAAQAFQENGTRRTRWDIRESIRAEARDRSASETAITESSSIHAVPITGTDPPAEAEQEGEAPPRNHVNGVTPVDTPGHAASASASVEHTQPQTNGGSEAATSGDSGNSSFGRRRARHRDRLNRRGQLFEDDVSGPEMGIDRIDSVVAGLSGILVETDVEQTVTQREDAEAVDAEAVDAETVDADTQDAETDAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQP6</accession>
    <name>A0A8G1VQP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="7 19">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO85DRAFT_182679</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines. Negatively regulates the biosynthesis of acetyl-CoA from pyruvate in the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 20">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="7 19"/>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518889.1">
        <property type="nucleotide sequence ID" value="XM_025654360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQP6"/>
    <dbReference type="GeneID" id="37157762"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000003">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="12 19 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="373"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RAH60967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="417" mass="44378" checksum="1198EDF1104B91CF" modified="2022-01-19" version="1">MSLTNKLAITDVDLKDKRVLIRVDFNVPLNDKKEITNNQRIVGALPTIKYAIDNGAKAVVLMSHLGRPDGKKNDKYSLKPVVAELEKLLGRSVVFTEDCVGPEAEEAVNKATGGQIVLLENLRFHAEEEGSSKDAEGKKVKADKEKVAEFRKGLTALGDVYINDAFGTAHRAHSSMVGVDLPQKASGFLVKKELEYFAKALESPQRPFLAILGGAKVSDKIQLIDNLLPKVNSLIITGAMAFTFKKTLEGVKIGNSLFDEAGSKIVGEVVEKAKKHDVKIVLPVDYVTADKFAADAKTGTATDAEGIPDGYMGLDVGEKSVELYKQTIAEAKTILWNGPPGVFEMEPFANGTKKTLDAVVSAAQSGSIVIIGGGDTATVAAKYGVEDKLSHVSTGGGASLELLEGKELPGVAALSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQR6</accession>
    <name>A0A8G1VQR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C4-dicarboxylate transporter/malic acid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_511576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516970.1">
        <property type="nucleotide sequence ID" value="XM_025664609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQR6"/>
    <dbReference type="GeneID" id="37168011"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09317">
        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF1">
        <property type="entry name" value="TRANSPORTER_MALIC ACID TRANSPORT PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH59048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="395" mass="44385" checksum="B072A0533694E686" modified="2022-01-19" version="1">MHSMTFVDRICRVSWGWFSVSMSTGSIGTLLYNTPHKFSGLMIIGKIFFILDIVTYLAIWASLITRFTRNRHAFRNTFNDPEEAYLIPTAALGFATILFGIECYGVPACGDWLKYVQLVLFWVYTAVAISLAVGLNWHLYQTRMASRQPFWLVRLLPSFPAMLGGTTASLLAGAQPNHFAIPILIAGTCLQGFGFLISLFILGEYFYGLHHHGLPPMRRRPQMFIAIGPPAFTAVALMGMAEVATEKFPAHYIPLASHVNTAEILLILAVFLSIFMWIFSFFLWMLGWLSILAAHHEWKFDITWWATVFPNTGFALATIKIGDLVASKPIQWVGSAATIIQVALWLGCFFLHIWAYLTRRTLWPGMDEGFEAEGHIGERLDMEGEVMSSKHSVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQU5</accession>
    <name>A0A8G1VQU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO85DRAFT_458325</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">In the C-terminal section; belongs to the NAGSA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">In the N-terminal section; belongs to the acetylglutamate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517060.1">
        <property type="nucleotide sequence ID" value="XM_025661577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQU5"/>
    <dbReference type="GeneID" id="37164979"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04252">
        <property type="entry name" value="AAK_NAGK-fArgBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23936">
        <property type="entry name" value="AGPR_C_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24149">
        <property type="entry name" value="AGPR_N_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04263">
        <property type="entry name" value="DUF619-NAGK-FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000019">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000154">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000029">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000011">
        <property type="entry name" value="N-acetyl-gamma-glutamyl-phosphate reductase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041734">
        <property type="entry name" value="NAGK-fArgBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011241">
        <property type="entry name" value="NAGK/NAGSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036440">
        <property type="entry name" value="ARG5-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 17" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="15 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16 17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12 17" id="KW-0521">NADP</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="19">
        <location>
            <begin position="357"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR036440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RAH59138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="908" mass="99272" checksum="F85019CEDE3C3A0D" modified="2022-01-19" version="1">MLAGNMFSLRTAVRRASSSKPLRAFSAQHAVSSARLGGASARQSLKASAVPLLQSRHYSRATDPQLSSTRSTVVQLLSNIGSKREVQQYLSHFTSVSSQQFAVIKVGGAIITEHLQTLSSALAFLNHVGLYPIVVHGAGPQLNRMLEDAGVEPQFEDGIRVTDGKTLALARKLFLEENLKLIEELERMGVRARPLNAGVFTADYLDKDKYNLVGKINGVNKKPIESAIEAGCLPILTSMAETPDGQVLNVNADVAAGELARALQPLKIVYLAEKGGLFNGDTGEKISVINLDEEYDHLMTQWWVRHGTRLKIKEMKDLLSDLPRTSSVAIIHPADLQKELFTDSGAGTLIRRGNKVHVKTSLSEFEDLEKLKEVLVRDREGLDARATVDRYVEGLKERDFKVYYDEPMEALAVVLPPQKDATSSLAHLATFTITKSGWLTNVADNVFASIKKDYPKLVWTVKEDDENLTWFFDKADGSLSREGEVLFWYGVESGEEVKQLVQEFNQHGRQMFGDINLESRLHRAAQAATHIGKGFGASGASAEQKRAFSSTSNALRAARSARPMVPVQTVRTYATTNPNPPLGEKNMSNTRPAKVALIGARGYTGQALISLLNAHPHMDLRHVSSRELVGKKLQGYDKREIIYENLSPDDVKRMSSNGDVDCWVMALPNGVCKPFVDAVDQGAEKGNVIVDLSADYRFDSNWTYGLPELVSRSKIAQATRIANPGCYATAAQIGIAPLVPFLGGQPTVFGVSGYSGAGTKPSPKNDVDNLTNNIIPYSLTDHIHEKEISAQLGTSIAFIPHVAVWFQGIHHTISIPLKEEMSSRDIRNIYQDRYAGEKLVKIVGEPPSVKDIAGRHGVEVGGFAVHSSGKRVVVCATIDNLLKGAATQCLQNMNLALGYGEYQGIPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRF6</accession>
    <name>A0A8G1VRF6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_476353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517645.1">
        <property type="nucleotide sequence ID" value="XM_025662775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRF6"/>
    <dbReference type="GeneID" id="37166177"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034237626" description="LysM domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="113"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="235" mass="25676" checksum="97EE13F79421C225" modified="2022-01-19" version="1">MKAFSQSLLALSLASVAVAAASCNTSALNTTTYNYYITVDGTTVFDVARATNRGVCDIGRQNLMADVTIVPNVGEYFIIPPEVCEPDNTSCLLPNINATRTCIYGGPRLYYTVRGDTYEVIARRLNITVESLMHVDGPSNETLTNPISPTAELDVGQFIKVPQCDPSQCVIQPYVFKWGVYKDLAEKYGTTVGQIMMMSPTYNYSSLAFSPEGMYPPINLPINCTALSNNMTTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VS09</accession>
    <name>A0A8G1VS09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uridylate kinase</fullName>
            <shortName evidence="9">UK</shortName>
            <ecNumber evidence="9">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:UMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxycytidylate kinase</fullName>
            <shortName evidence="9">CK</shortName>
            <shortName evidence="9">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate kinase</fullName>
            <shortName evidence="9">UMP kinase</shortName>
            <shortName evidence="9">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_134551</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Predominantly cytoplasmic.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="9"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520329.1">
        <property type="nucleotide sequence ID" value="XM_025654025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VS09"/>
    <dbReference type="GeneID" id="37157427"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016776">
        <property type="term" value="F:phosphotransferase activity, phosphate group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009123">
        <property type="term" value="P:nucleoside monophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="9">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="22"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="70"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH62407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="213" mass="23606" checksum="AD2D00CED10265CE" modified="2022-01-19" version="1">MTTQPRFSPTDITVVFILGGPGSGKGTQSSNLVRDYGFTHLSAGDLLRAEQVREGSQYGDLIKTYIREGKIVPMEITVALLSNAMADALASGKKQQQEGGPKPRFLIDGFPRKLDQAVFFEDTVCPSEMTLFLDCPEEVMETRLLKRGETSGRDDDNAESIRKRFRTFVETSMPVVKAFEEQNKVVSVTATGSVDEVYERIREGFKSKGINPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSD2</accession>
    <name>A0A8G1VSD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Stage V sporulation protein k</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_433403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520734.1">
        <property type="nucleotide sequence ID" value="XM_025658421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSD2"/>
    <dbReference type="GeneID" id="37161823"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000216">
        <property type="entry name" value="Type VII secretion ATPase EccA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050773">
        <property type="entry name" value="CbxX/CfxQ_RuBisCO_ESX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN / ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392:SF2">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN _ ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="32"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH62812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="273" mass="30689" checksum="03AD8D5488DB26C7" modified="2022-01-19" version="1">MIGMDPIIYLFRSYQMLSSGMRLQGIDPRPYNPFAFVFKGPPGTGKTTTARICGDIFYEMGFLSTSEVIDCSATDLIGEYEGQTGPKVINLLERALGKVLFIDEAYRLAGMSTGNCSSFANEAVGELVDCMTKQRYSRKPVIVLAGYSDDMDRLLHINTGLRSRFPTDIVFPSMSPAHCLEYLEVQLGKLQIRVDRSPTISEREDSTVRDLFARLQKTRSWANAWDVETLARNIVFEVYKSQRGTSDSDLSVSMDDIMNCLDDMLDQRDQSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSM0</accession>
    <name>A0A8G1VSM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_444424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521002.1">
        <property type="nucleotide sequence ID" value="XM_025659015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSM0"/>
    <dbReference type="GeneID" id="37162417"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF1">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05752)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="789"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH63080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1011" mass="112915" checksum="FBF1A8006C93416B" modified="2022-01-19" version="1">MTIPTDSQSSPQQTELETQRDPSSNNSGPVPVPVPGSAPLPATTSDSSSTTTAVTGTTMADASGPVSSPESKLDADPPVDAPPVKSDPKAPVSVSDPVPKKSVCSKHAAKDQDPNRSKKKKSHRKAASIVTPSDDSSSELNASSEESSAESTSDDEDAQSASESDAESDRKQRRRRAKNKIKKSLKSVSRKKKSRSHQTESESDSDLEDSSDSDSSLDEKTLKKLVAKLKAKKTTKKSRSKDDSSEEQQDDDDDADEDADADELALLLAKQKLASLRVKLADGRRKGRGRRGSGDGNTDGQKGSSQKSKGRKKAASKIAFKRVDQLWDNTIHNFKLTETVDDPDANEWDQYLFTVRRKFDWDNKYLETVVDLKSKYLRDALSKVMDGVKGVSLVQETAVVDPNMLFLYLEETRQYMKDLRQLAKTEKKKKARKLAEIKASHLKVLVKYLDTDYAETKKTLYPLLDSSMITFDLLWAIFKPNTVAYSSTYGNQDEPRAFKIEYATKESSFMKGQWYSIEGRYLEYDGKAFGMGTMAAEVESFKGARKITSLSCYPLKYHREAESVKAKLIERGKKFVALRGMNYRYHKGMAFYKKKRSVIKVNINGRVMVDPAIHRRINPNYPISTVRPKDPDYLDGSDDDGSNNGCCCILSDSESEQTYGQPRDSDTPQLLFKVVRDKEGKPHVVEVELDENGNEIVKENMDEVADPSDREFTEEELLIASPVVLGFAFSEKLWLEFSISGISEIEWNEDAFDSLVLPDNQKSIVKALVESHTFRAAQNIDDVIQGKGKGLVAVLHGPPGTGKTLTAEGIAELLKRPLYMVSAGELGTDPRTLEAELNKILDIAHSWGAVLLLDEADIFLEKRTIQDIHRNALVSIFLRLLEYFQGILFLTTNRVETFDDAFQSRIHVALRYGELTTKAKRSVWKMFLERVQAKEGVETATFTEKDFDLLARHNLNGRQIKNSVRTAQALAVNEQNPLSMEHIRRVLEVAETFDRDLRGGSGYLDAMRSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VV14</accession>
    <name>A0A8G1VV14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosyl-DNA phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_387695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521320.1">
        <property type="nucleotide sequence ID" value="XM_025656680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VV14"/>
    <dbReference type="GeneID" id="37160082"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09122">
        <property type="entry name" value="PLDc_Tdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="599"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="599"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="3">
        <location>
            <position position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH63398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="671" mass="75166" checksum="83E791EB37BBDDCC" modified="2022-01-19" version="1">MAPHEGERQFETFDLDSEPDQRRSSERQVVDLTAESDSDDVVPIFPKSQSVIGSDTDDEAGDDDQYDEDLKRAIALSLQDAQGGSQNASSYPQISDSEKGEPQGTDSPSVEEVEEKTNGQEPAKSMGIFGLDRKQMEQERLARLAKRKAEDTSSIDLRETKHSKIDLAPKPTPTSSRSIPSTSPSVQYPEGIVKKTWAFGCPRQGDDIKIEEVLQKSDLELAVLSSFMWEMDWLFSKFNVESTRFIMVMQAEDEATKRQYESETATMRNLRLCFPPMGGQVVCMHSKLMLLFHPGYLRLVVPTANLTPFDWGEMNGVMENSVFLIDLPKKNGAEKPTTHFYEDLVHFLKASTLHENVIAKLDSFDFSKTSKYAFVHTIGGSHTDTAWRRTGYCGLGRAVERMNLRTSVPLNIDFIASSVGAITDQFLRSLYLASQGDDGLTEFTIRYSKSCPVPRRDDPSKLLKKDTGTEWKDRFRLYFPSQNTIATSKGGPRCAGTICFQSRWYNGENFPRHILRDCESQRKGLLMHNKILYVRPDEPIPLSESTQCRAWAYIGSANLSESAWGRLVQDRSTKSPKLNCRNWECGVIVPVIEDKTDTPEVKNKMISEDKGKGKGKASESSSSSSSSTNNDDDDGRNLPAIFGDTVPVPMRVPGARYSGGRKPWFFAESQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQJ5</accession>
    <name>A0A8G1QQJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rho GTPase activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_240474</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825093">
        <property type="protein sequence ID" value="RAH51813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509735.1">
        <property type="nucleotide sequence ID" value="XM_025654837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQJ5"/>
    <dbReference type="GeneID" id="37158239"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09391">
        <property type="entry name" value="LIM1_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09392">
        <property type="entry name" value="LIM2_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04397">
        <property type="entry name" value="RhoGAP_fLRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000033">
        <property type="entry name" value="Rho GTPase activator (Lrg11)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000112">
        <property type="entry name" value="Rho GTPase activator (Lrg11)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000058">
        <property type="entry name" value="Rho GTPase activator Lrg11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF10">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="125"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="189"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="863"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="602"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1101"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1106"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1135"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1158"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1184"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH51813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1217" mass="134911" checksum="0C8CA82A5F707FEE" modified="2022-01-19" version="1">MPPGDVPLPDSLVPGNGAVRPKLNTSGYGGGSYQSQTPTSPADSNIIFDSPRTRTGGWNGSTNSPVEGPQGSDSRMSRRLESGHPGPRDPSTPRDRNGYWDRSTPRERSRPNGRPPTKSPGSSSRICKKCGEPLTGQFVRALQATYHLECFKCEDCGQIVASKFFPVDAEDGSGQYPLCETDYFRRLDLLCHECGGALRGSYITALERKYHIEHFTCSVCPTVFGAQDSYYEHEGKVYCHFHYSTQFAQRCHGCHTAILKQFVEIFRNGQNQHWHPECYMIHKFWNVRLAPTGQPLEPPEVETDATDEERNRVREEEDIMEEKVYKIWSILSSFEESSAACISDMLLHVSNGTYLDGVLVAKRFIGHVDILFSAIDQLAGHIKEQGMKDLAYGREAKLLCKKIVAFFALLSKTQETGVRKLGVTQELLSLVTGLAHYLKLLIRIGLQGALKLEREQQASQGLHHFLDHLGDLETLRPPEEEETLADLMTGVDTLADQLSDCCTACKEPIDDECVMLGDSRWHIKPPHLTCASCQKELSHTLQDALWNPKEKRSFCTDCVSQNGLMHDVQGGFTHITKLQQFVFLLKVALARLLAVLRAGGSLGSGDASPPQDGNESGRIPPGGEMRRSATRSKSYANATRNAPEGSSLEQTVGEMRRLRSIRNERTLSTTYKKARASRIIDGPEGRSVRPGSSGGEGSDPRGHGFQIVEERDANGETVTELTFGNQDALTLDDIPRIVAAEQAKEQRPNAYKHAGTKLVGTTEPLPKYNYGHQRGVSGAGLDQHIIEQGGRTKKYFSELSALEYFIVRHVAVLSMEPLLSEYFTLEELLSLIESRKPTIWNIFGRAFNKEGKKVGKKKGVFGVNLDFLVEREGTESSHGVGPGQLRIPALVDDAVSAMRQMDMSVEGVFRKNGNIRRLKDISEMIDNKYEQVDMTKENPVQIAALLKKFLREMPDPLLTFKLHRLFVVSQKLPDPEKQKRVLHLTCCLLPKAHRDTMEVLFAFLNWTSSFSHVDEESGSKMDIHNLATVMTPNILYPNAKNSTVDESFLAIEAVNCLITYNDTMCEIPEDLQSVLSDTTFFKENTEVTTKEILRRYGDIARGSFSPKASNGGETVTITNSNRAANIPTSARIETDPSQDTAWQMQSSVRHVQSPGGHQHSTSGTPQAGTELAPTASNDYRERSTSNGSQQNPMQAEGQSQPMPYRARPGAGPMGVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQW1</accession>
    <name>A0A8G1QQW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="3 16">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO85DRAFT_454378</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 16">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the COMPASS (Set1C) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the Set1C/COMPASS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="3 16"/>
    <dbReference type="EMBL" id="KZ825090">
        <property type="protein sequence ID" value="RAH51932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509854.1">
        <property type="nucleotide sequence ID" value="XM_025661272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQW1"/>
    <dbReference type="GeneID" id="37164674"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20072">
        <property type="entry name" value="SET_SET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017111">
        <property type="entry name" value="Set1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024636">
        <property type="entry name" value="SET_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11767">
        <property type="entry name" value="SET_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037104">
        <property type="entry name" value="Histone_H3-K4_mtfrase_Set1_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 16" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="COMPASS complex Set1 subunit N-SET" evidence="20">
        <location>
            <begin position="917"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="1097"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="19">
        <location>
            <begin position="1223"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="360"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="508"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="602"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="675"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="524"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="602"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="621"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="687"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="743"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RAH51932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1239" mass="139124" checksum="6667C5D138EA5E86" modified="2022-01-19" version="1">MSRSSAGFADFFPTAPSVLQQKRKTIRERPRSEAHPEHDHSDEGRALPEEPKAILELTPGLYAEEQNLPTVKGDGLASSDSVSVSAARPSTHTHSTAYGNEARLDTLTPLTNAESSPAQRLSPSHIRIANGIEDSSGTMKTDDIKPAMTPLQTPPTPRSQSRTSGNVRGWKLVYDPDSEKRISSKEKRRKARYVDIVPNGQDDRPADPRLKISNYSRGGGCKQKTKFRPAPYSLKHWSYDASTTIGPGPPVQIVVTGFDPLTPIAPINALFSSFGEIAEINNRTDPITGRFLGICSVKYKDSASFRGGGPVLAANAARRAYYECKKEQRIGTRRIRVELDRDGIVSAKIVTRAVDSQRMGDRNNLLSAEEPKTGVSAKNNEPPPTAPKGPSGRSQMRPTVPVPEGPRASFLKPVVPSLVEEIPILSQIKRDPYIFIAHCYVPVLSTTVPHLKKRLKLFDWKDIRCDKTGYYIVFENSRRGEEETERCYKMCHMKPLFTYIMNMESQPYGNPNYERSPSPQRLQAEQRERAEKDRVKREAELDIEEEKRQRALDLDPCREVVAIIIRDLRDKLLEDVKSRIAAPALYDYLDPVRHATKRERLGIPEPEGAKRPMFRIDLDSSAGTPDSRSDLSTSRNPLGSSGLNILALPRIRKAHRLDRTNAAFLDERRKQPLRKKEVRPLYHRLQQLHDVDDSDDEQRTPFTRDTEDLDSRAPSRMSSETSDSEEDSDRIGSETLEVPVAERQTDSDRSHDIDITRDDESGVSPSEAPEQVPDRLQSSSRKRKVDDDRAKARKKQKGGDECFDMDDAAGSGEDQDMACSPSRSDTIQDVIAAAGEPSVTGTDSLVSHGQLAGHGQKDDAVALMDSWGADVEYKGLGKDHRHLVSQVGSFEHGKQTEEPRTEIEWRVSNDEPRSTVDDDESIVLDLDGWQNLVKDEEDLCFLRDVLREFSRSNVGNLSAWAWRQKEIKALNRPEESGPVREETVIPGYYVSNTTGAARTEGRKRILESEKSKYLPHRIKVQKAREEREARAKSDPHAVAAEAARIAAAKTISKSTSRSTRVNNRRLIADINAQKQALPTQSGDGDVLRFNQLKKRKKPVRFARSAIHNWGLYAEENISANDMIIEYVGEKVRQQVADMRERRYLKSGIGSSYLFRIDENTVIDATKRGGIARFINHSCTPNCTAKIIKVDGSKRIVIYALRDIERDEELTYDYKFEREWDSDDRIPCLCGSTGCKGFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QR51</accession>
    <name>A0A8G1QR51_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-1,6-mannosyltransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_207763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510210.1">
        <property type="nucleotide sequence ID" value="XM_025654586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QR51"/>
    <dbReference type="GeneID" id="37157988"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="307" mass="34609" checksum="F1EFB97ED1929B09" modified="2022-01-19" version="1">MRRRCLWVIQAIVLLGLLAVFYLTQLQSQALLQQDPGTINPLKVAIPHTVHQLFISTPGSRGSSFYPDRHSTSWLQSGWKVEYWRESSCYELAQELDDTGSYAATFQALPVPILKSDFCRYLILFGRGGIYNDVDVHLLHPLPWPVMGAVNDGVDEPPAVIVGLEGDAATTGLPRSPQFVQWTMASVPGHPIFRDVLQSIVDRTAHYISTQIAETDADIDVMGWTGPSAWTDAVLEYLHCDDEQIQQLRDLHEVVRVRDVIILPRRSFAVLQGEDQTAPDVLVKHYFSGSWKTCAREWLRWLWPGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTB8</accession>
    <name>A0A8G1QTB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_472068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025662531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTB8"/>
    <dbReference type="GeneID" id="37165933"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF4">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="240" mass="26573" checksum="9379251A3DDDFC76" modified="2022-01-19" version="1">MTGSKNVVFDIVGTLVSYDVLFDAIDTQLGDRLRAEGIKPSLLGYTWIEVAEREYTYLSLSGQYKTFATCLELLFWRMLKMAGIQDPRSFATKSDLEFIMSRYAKLGLRPGAAECVTKLRDAGFTVWALTAGDAARVGGYFANAGLEWPAENLKSCDSQGIGKPDLRVYQPLLEQLSQHGQPWFAAGHMWDVSAARRAGYKGAYCTIWEKEPIVGLFGEMEVMADTLPAMADEIIAAENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTD3</accession>
    <name>A0A8G1QTD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_493305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510151.1">
        <property type="nucleotide sequence ID" value="XM_025663821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTD3"/>
    <dbReference type="GeneID" id="37167223"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="78" mass="8662" checksum="C587303111012F77" modified="2022-01-19" version="1">MKTANSSVSQHTELFYYALDQLTASSKRNLEEMISRESRSLVLYFILTQSALSITVAPLAIDTNHNLSDPGVDMINAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTG3</accession>
    <name>A0A8G1QTG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_380424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511888.1">
        <property type="nucleotide sequence ID" value="XM_025656381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTG3"/>
    <dbReference type="GeneID" id="37159783"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="657" mass="72489" checksum="4820B7BF071F3554" modified="2022-01-19" version="1">MASTKGVAAGRKKDAIHFVNARPASETERIKIQRLVRAHVGKWISDQTKDRSSGPESPDSNQSQSSSSSPDATSQSPPQGAVPPGPGLHLLTPPNGSPSPAALTPSALPLTFPSQHTPPSGTPIRRTSSDLSTTPSPECGYADCPPSAQGVAGESQFQFDPEELELSPETVWQFQQQTLDETPYDQSETTKRTTTSDSFSAPAPSSATSMDFIESFGCVAVDPFHTNPMDLARTEIAATEEYCLYVLWPGLTPVSPGQETRPSSTSWLPLALQDRTLFTAFVFGSLSHKRLRWLNGWIARESFLPEEQRILQWCELETIQNVTREVSNPSRAVCDSVILAVICMAHNVAEDHGRGIHRTPPFDPPLPRLQWLDVYGALPPNLVHIKGLVQMVRLRGGIENLTLPGLAATLSFSDIVTCSTFLMPPVFTFIPLFHERRNFTLQKMLGFTTVDVERRYAPLRDIGLTAELVEVLYAMHIYMRLVEEHIKAHLVNPDYSLISDQRNLTQYTLLSLPAASQLEGFSAYKPHEIIYEACRLAALIYGVGVVFPLPYQSTPLGQLAKLTQNVLQISDLASTWSHPQARIALFWVLVLGGIAADDRPERAWFVHVLSQAAASHGIRSWVDARKLLGLMVWSDRACDRPGSDLWAEVKLAMVRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTZ6</accession>
    <name>A0A8G1QTZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UbiA prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_462473</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512203.1">
        <property type="nucleotide sequence ID" value="XM_025661853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTZ6"/>
    <dbReference type="GeneID" id="37165255"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000008">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH54281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="314" mass="34669" checksum="16552A0E563BE244" modified="2022-01-19" version="1">MDVAGKLIPETDMLDDHTRKRIRAIWEMGRLHTHETWLSVFPAVWGASIGAKSGRTDGWSLACVLFGIWASATVSHAAFCSWNDICDVEYDRQVERCKSRPLPSGLVSVKEATFFFLCWMLLTMGTTWYTLGPQATLCTAPAWLLGLIYPFMKRVMPFPQLVVGLSIASGVMPGYVSVKGDIGFDGSVLSLFGATVCWIIFLDTAYAVQDMVDDAKCGVQSLAVFLGQRVRVFLALAAVVSIAFFVVAAFLSNRSPFYWIFGIGIWVVSTIRSISLLDLSDCASGGRVFKFNIKAGFYLTVVTLVEGYLQAYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QU33</accession>
    <name>A0A8G1QU33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Exosome complex exonuclease Rrp40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_453756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510779.1">
        <property type="nucleotide sequence ID" value="XM_025661125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QU33"/>
    <dbReference type="GeneID" id="37164527"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000112">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000091">
        <property type="entry name" value="Putative exosome complex exonuclease Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041054">
        <property type="entry name" value="Rrp40_N_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18311">
        <property type="entry name" value="Rrp40_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exosome complex exonuclease Rrp40 N-terminal" evidence="6">
        <location>
            <begin position="26"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="173"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="29209" checksum="AACD86BBF6513EED" modified="2022-01-19" version="1">MSSPLILLPGDEIPSEYLPSTNSAPLRLGPGLRLLSQPPSSSPQASSSPSHVLTATQAGILSTDTKRNAVSILSTPNRRYIPTVNDLVIAQVHHSSVDYFHCMITPQAPHAVLGQLSFEGATKKTRPMLKQGDLVYARVLSVGLGAGAEVELACVNPATGKAEPGGLGQLNGGMVFDVSTGMAARLMRASSSSSDSQDGAAGLVVLEELGKKLEKSGGFEIAVGRNGKVWVDCSSGGETSVKATVAVGRCLTTIDEHDLNPADQKKLVSRILREMKIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUQ4</accession>
    <name>A0A8G1QUQ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_156078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511248.1">
        <property type="nucleotide sequence ID" value="XM_025654191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUQ4"/>
    <dbReference type="GeneID" id="37157593"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13743" checksum="B96F11C443B10453" modified="2022-01-19" version="1">MDSSIITTLSPLVPSHISQTHPPVRQYLIVRRYYNTVSDTPCGSQELQEVHFHRGKRKSRRVDILEEKEIEAQNFPPSLSNYQYGFFLLLLPFLFQLLMSVFPVVNTRSMSWQSKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUT4</accession>
    <name>A0A8G1QUT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_491317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511976.1">
        <property type="nucleotide sequence ID" value="XM_025663706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUT4"/>
    <dbReference type="GeneID" id="37167108"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="147" mass="15926" checksum="FFEBE66FF42E011B" modified="2022-01-19" version="1">MLIAEPFPGYRDSGADIVYTLLQKGVKVLKSDPSAPVSPNEGWAFPDTEEGIYSAAQQGATYSWANTILFTSHPLQISSKLTPVASEIYAVGQSPGLVESFDDKAYLNDKLRELGGYTLPKSCLVSPENISEIINYIDRCPIVGNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVD0</accession>
    <name>A0A8G1QVD0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-haloalkanoic acid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_378980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512276.1">
        <property type="nucleotide sequence ID" value="XM_025656320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVD0"/>
    <dbReference type="GeneID" id="37159722"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF4">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="239" mass="26385" checksum="7B5EC1CFDF043C11" modified="2022-01-19" version="1">MPNHVVFDVVGTCVSFDAFYATIERTLGPQLKAHNITAQTLGFTWMTNAELQFTFLSISESYKPYKIVITELFYQTLAMIGISDPHSFATPEQRDACVAGYAALELRPGARECFAKLRDAGFTVWCLTTGDTQRVRGYFERAGVDMPLENFLSCDTAGVAKPALAAYRPAWERLGNEGGEKWFAAAHLWDVTAATKVGFRGAYCTVYEKEGAYKVFDAPLDVVSESLPEMAEKIIAASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVH0</accession>
    <name>A0A8G1QVH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_499709</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512520.1">
        <property type="nucleotide sequence ID" value="XM_025664076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVH0"/>
    <dbReference type="GeneID" id="37167478"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF167">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="46"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH54598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="366" mass="40281" checksum="4EFAB82A9C0D1E39" modified="2022-01-19" version="1">MTPLPGRTGDPRQILWLRDESGGSNASGILAAVGTLTGLSTLVLWLRCYVRGYLLRRFNAEEYIITVAWLCAVGVLVCFVLEAQHGVGHFSKDITDEDEQVLSKLVYYHSIIVMVGLSLVKISLAVFLRRFSSTILSKALVGSIIFLVAFTIACGLTLILQCIPIAAAWDTSLRPHARCFDNDTYTAIGLWNSITNLVTDVIFATLPIPLFIGIQVNWRIKFSLIGVLSLGYLACVAGIVKIISQVNVLKEQNMYRAELNVAILAACLPSLKPLLKSVLDGTRSLTTGRRNTSAYRYDTQGYYVQRSTDIAMKSMPRVPPTVYDVTAAGSSDGESGNWRESDEQRLHRTETGIMKTTEVVIQTHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVH5</accession>
    <name>A0A8G1QVH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_504650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511291.1">
        <property type="nucleotide sequence ID" value="XM_025664307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVH5"/>
    <dbReference type="GeneID" id="37167709"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="73" mass="8199" checksum="59097409509839FE" modified="2022-01-19" version="1" fragment="single">FGTFDLSTDSWGSTRWLTNWWGDGEPVTPGRFRLSALSAAMTTVTLTAILTSRFPYRHPRRSSSYGHVSQTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QW84</accession>
    <name>A0A8G1QW84_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_403607</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512741.1">
        <property type="nucleotide sequence ID" value="XM_025657235.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37160637"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002039">
        <property type="entry name" value="ABC multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="542"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="913"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="960"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1048"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="305"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="631"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="925"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1243"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="849"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="849"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH54819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1499" mass="166118" checksum="A2C2F97C25C0FDE6" modified="2022-01-19" version="1">MEHLAAIVPAAVVPLAVQGGAGEIAYTPHPGLVQRELWQYRTRKASAFVGSGNLHLAAILASWIVVLLSISLRYIRSYRKKSPSPKTTPHDQSEIVVSLPFAFAHLAVAIAACCLTWVDIHNGESWKRSALLTYVVLLGIGRLCIKRYDYRRHMYWHMNAMVTAALILAVVQDIVPMMVIGATYRPTSIGVAIVACLAAVVAIAAATPRPRRSLVHNAETDDLVVEEKASPEETCSLFSYYCSYEWITHVILRGCQRDLTLDDLPPLPSYDEPLKWLEKIKKQRLKGGKTFRTLCRMLKTEIKTMMFWAALTAVVDFLAPYSMLRLLAYLENPSSAVLHPALWIALLFAGPATRSLCYQQYIFTATRLLVRVNVSLVQELYQTAMRSYIYDDSVGHSSGKHAKSKHRAESKGASKSSQANLTSLMSYDVDAIYNSRDIFYIATAGPISTTLALVFLYQMLGWPSLFGVLMLLCLSPLPALASRKVSRIQRTVMQATDARLSKISEYLGSIRTLKYFGWEHAAMNNINDVRRVEQRHLWRRSVFVALISMGGELLPLLSLLVMFSVYILFTDLPLRAPVAFTSLSIMETLRVQFIWLSNISRYTAQGSESLRRVDRFFDTASEIKRHPDGPLELKNATFRRTPIAAFRLQDITLRFKPNALNVVTGPTGCGKTSLLLSFLGETVLESGTATCPRDVAYVPQAPWLQNDTIRQNIVFYSPFDEARYAMAIEASGLTQDLQQLPAGDLTMVGERGTSLSGGQKQRVSLARALYSPSNTLLFDDIFSALDTHTTSLVYEKCFRSGLLKDRTVVLITHYPAALQDADLVIRLEHGRIVPARAISKSTLSLMSSRCTTPGTDTDSSVSESNVRVADEALESPSEPPPVAPAGKQPPAEERIAKETSATGRVPRTLALRYMMLFGGASYVPLVVIATISVQFAYFAITYWLSIWTGAYDKYEHPNTLFYLGIYAACIVTFLTLQLCNNLIYQYGSWVAAKKTHHRLVTAVLSAPIAWFDQNPIGRAINRFGNDTRSLDTVLVEWLRMSIENTLRFLLRIASVASIMPIFALPAAVICAAGFVIGEMYTRAQVSIKRLTSINYSPVFSHFTDSLSGLSVIRARHGMDQVFQNLLAEKLAVHARSSEAQYNCNRWVSVRTDFCAASVAAAAGCVAYFWSGSAGLVGFSLTNAIGLSQTILTLVRTLNELEVELNSFQRMTEYGDIEPEEKLETEEQRKADALPASWPTSGRVEFNNVTARYQPDGPDVLRKVSFVAHPGERVGIVGRTGSGKSTLGLSLLRFVDIVDGSVTIDGVNIDQIRLNRLRTNVTLIPQEPVLFSGDVQSNLDPFGGSSETELRAALSACTTVHVPGEGEGESRTMRPLALDTPVAANGENFSQGQRQVLSLARAMCRRSKVVLLDEATASVDHETDSHMQKVLRTMFADCTIIAIAHRLRTIMDYDRVLVMADGEIIENDSPARLVAKKGVFWEMVRNTGEYEELIEMMESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QW92</accession>
    <name>A0A8G1QW92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_379523</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512088.1">
        <property type="nucleotide sequence ID" value="XM_025656345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QW92"/>
    <dbReference type="GeneID" id="37159747"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF20">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="11"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH54166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="468" mass="50826" checksum="65E048C0A7C6B25B" modified="2022-01-19" version="1">MVSPKGKVFLIAGHVALAGLLYGLDTGSIGPVTQMPQFESSIGRLSSTQQGVYVACILLSSSASSLASGHVSDRISRKYGILIGSLLSLAGTIISACSPNFASLIVARLITGVGMGQAISVTTVYLVEIAPADVRGVVACSLQLYVVFGIMAGYFITYGTQYLSGSMSWRVPFIIQAIMAAVLSVVMLLLPFSPRWLVQVGRNEDARQVLRELRPESTVDDELREIQDSLQSDQRRPTASMAEIFGRKYIGRTSLGVFLMTFQQLTGIDVVLYYAPILFQQAGFTSTKASFLSSGIIGIVMLVFTIPAQIWVDRWGRRKPLITGGSAMSICFIIIGALYARYGHTTHDAVTLESHSAQWAVVVLIFIFVANFSWSWAVVGKIYASEIIPTRLRAKVCAVELLANWIVNFIVTLTAPLFLHRSPSGPYFLYGFSTLVAVAVCVLMPETKGKSLESIEELFEKGEDNEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWE0</accession>
    <name>A0A8G1QWE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">40S ribosomal protein S2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_522303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512816.1">
        <property type="nucleotide sequence ID" value="XM_025665254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWE0"/>
    <dbReference type="GeneID" id="37168656"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000061">
        <property type="entry name" value="40S ribosomal protein S2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH54894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="374" mass="41274" checksum="779B7DC2C64BC8E0" modified="2022-01-19" version="1">MIVRQLVRQSRQLRALPRQSRILSRFSSTETTGQTPVQTIVAEQAPQLETPAPAVAVPEPGTSGAQENLDPNTLRRIKFHSLGSDVTGVYRPESLLKNPPKATDVTLEMLLANQTHLGHSTSRWNPQNSRYIFGIREGTHIISLDITAAYLRRAAKIVEEVAYRGGLVLFAGTRKGQKRAVVRAAELAQGYHIFERWIPGSLTNGQQILGHCEKKIVNGFDETIEDLWKEELEGYRALKPDLVVCLNPVENVVLLHECGLNNVPTIGIIDTDADPTRVTYPIPANDDSLRSVTLIAGVLGRAGEAGQQRRLAQARKGEWTYKLMQPLRQQVEETTLETAEGQTPEASQDLVSEEVPSEGSPLDKPKEGASKDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX51</accession>
    <name>A0A8G1QX51_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_505557</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510912.1">
        <property type="nucleotide sequence ID" value="XM_025664337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX51"/>
    <dbReference type="GeneID" id="37167739"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH52990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="530" mass="60574" checksum="EAB8521CD17CF869" modified="2022-01-19" version="1">MSNSIHAQISGLAKENPLLATLVTIAAFLATIFLVVREIFTPVGKRRPPHGKRWKLPPGPKGIPIFGSLLDIRKIRNDEDHIINNELAQYGEMTTLHLGSKTWILLNSKRVVSEIIAKRGTLTNGRSPMPVASGIVSRNGRSLLLPPSGWTEKRRVMHSLLSGTALKQYASWQELESTQLLAEYLFQPERWYRHHYRYANSVVHRIALGERLVKSGKELEDLQNVVTYFVGSIGSSLIDWFPELDRLPRVLQPWRKHWEKLGDWNEEVYKSWWIPVREKVEQGTAPPSWVRDVLLHPDTKFTGDDQEAMYVALQLLEAGSDTTREVLNIFAMAAICYPKVFQKAREEVDRLCCNDGSLRLPGIDDLENMPYICALIKELLRWRPIFVLTPDHVLTSDMGFEGYHFPAGVGFVINEVPVCNECEDPEEFKPERWLDGHETDAAHGLWQFGGGRRICVGYRLAFRGLFINVARLVFCYDYAAAGPYNPKRLNHHKTDEPFPVKVTPRSEDHVKLILREGESQQVLEDAKRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX93</accession>
    <name>A0A8G1QX93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SWIRM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_376583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513495.1">
        <property type="nucleotide sequence ID" value="XM_025656230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX93"/>
    <dbReference type="GeneID" id="37159632"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF21">
        <property type="entry name" value="SWIRM DOMAIN-CONTAINING PROTEIN FUN19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="2">
        <location>
            <begin position="295"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="396" mass="44594" checksum="14C5AE96672341D5" modified="2022-01-19" version="1">MTSFTAASLPSRGDKVNMSRLPSVSSLMSPPETKPLESFSPTTISPYTMAQDPPYNHEVRLPPMPSDHKRTQSEMNLPSPPVTPYTGNKKRRSNGPEPIDKDAVVGSSRDPVLFPRHEGLTDIATDEPLFGSMLPPSAEALVDQHINSHMARFENKLNKPTRDEYLLALSCVPIVSAQFNRNPAAWAREERETLERQLLMMNRCRPRAIDAKLKKIAPAPAKRAVAAQPRLQRTPRVKRTPKSTPKQRILDTFDSPPSSAKPPRAIGTNRDDTDYNSIKDYCPSIETLGGNAKALKADWKGQVLDLSHDPDRHLLSSAELNLAATLRLSCATYLCSKRRIFEARVKALNVGKEFRKTDAQQACKIDVNKASKLWTAYERVGWFDPEHFRQYRQYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXV9</accession>
    <name>A0A8G1QXV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_405907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511272.1">
        <property type="nucleotide sequence ID" value="XM_025657317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXV9"/>
    <dbReference type="GeneID" id="37160719"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034472063" description="Phosphoglycerate mutase family protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19237" checksum="17E4305F1242D77E" modified="2022-01-19" version="1">MYSTLSLSLGLLATASLALAEPTVYLIRHGEKPSNGSTGLNAVGFERADCLKTVFGPDSNYDIGYIIAEQPKSDGKRDRAYETVLPLAEELGLTVDTSCSKKDTKCVKDLVKDYTGSDNILICWEHKELTKIAEKLGDDDAPTYPDDRFDLIWTDPYPYTNITDITSENCPGLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY77</accession>
    <name>A0A8G1QY77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_425703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513108.1">
        <property type="nucleotide sequence ID" value="XM_025658088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QY77"/>
    <dbReference type="GeneID" id="37161490"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="887" mass="98774" checksum="AAD379CA24D29C5B" modified="2022-01-19" version="1">MDSYHTLSASSNMTGPSSLFLGSRVSSDVENLTDEEEEFMSSASTTSHGSEERTENRSEHEMKTEDTSVDIPVTPPRNSIQKDVGSGTCQSSHSERDATPLSTTERPLRLLDMPIDILQVIIKEVTHTNDLTSLALTCSALHSLAIPQMYSRFDIVWPETLSSSDHPAGVDALSYGLATLVMGQDIFRELPPRRAQPCPHCGCHGPAPSQDNPTDTLLKIRRGNYYAQYTRKFSVGNGPLVWVQEYSVTKETGKMLGTLVALAVARMVNLETFVWDMPTGVLRDVWIALSSLANRPGHDCRLQRVWVRWHDNSENTMRPLAGPSTASSVTLPDTQALAGSASNSSLLQRYGHVEYPSLSILPPLKSLSVLDIDEPSYLEEMAVLVERSRDRLKELRIGISSKVYQASWLKPAGSWQAEQPTTSRGHSGWPKSGGVLGVVLGRSEEPTHPSRIQADSVPKQEAPESLAENNQPENQALSLINSTPGSPLPADGIASIALNMQNTHIAQQQPPIASETKLSREIPNSCSEKPLAVPGSSHQILKLDTLELERVPLSIPVALHALDWTQLTTLTIFRCESHEKLWRALRRQFSPSVSSRSKHGRREGDQSASEYRLNLRHIHTDAVSPYLLLFIKDTLAPNTLQTLFLHEAPMYDSIVHIDAIYKNAIKTHHLSLQKILVDSTQRAPGGSEMPSVRWYKWMFTRQMLTFLSSGRMPRLRELSIALHSKDWHYFLQRLPYMPQLRALHIPHIARQAHRDPKELAMMILDIVTIRPEVGITYVGIQNKCYEILEAKEGDAGEFYDTDDSHSEGFVPGGEEWAGSDTNEDESDDDGGISAMDSHSDLSSDDRISSDGEGSEMDYNKSRVSYRLREILFYDDKIAIFKARHGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ38</accession>
    <name>A0A8G1QZ38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_452254</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512732.1">
        <property type="nucleotide sequence ID" value="XM_025660776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ38"/>
    <dbReference type="GeneID" id="37164178"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17956">
        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="290"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="667"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="597"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="607"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH54810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="862" mass="93100" checksum="CEA7B3D6F3CE95E6" modified="2022-01-19" version="1">MAGDRSASHDPARTSSGTPSSAKKSHKRKRDLDGSATAISTPTPTKKSKKNQGSPSNDTPVKESRKKKKHSGAASRSAVQETSPQKESALSLVGGQTTTSNQDDSLTKKKKKKSKDGKRKSGTIGDAAEEDVDMKDADDIEEAKEEEAKGTKKSRKTSDPATTEDDDDKPTKNKFAGILSKFERSKKARELEKTKESMKDEDSTELTTAEPVVAQGLEPLPQPEAAPEQDEMPTYSSLPPWLANPLRASAQERRKFADLGIDSSLLRVLEDNGYHEAFAVQSTVIPLLLQGPTNHPGDLCISAATGSGKTLSYVLPLVTALKPLPAPRLRGLIVVPTRELVKQAREACELCAAGSGLRVASAVGNVAIKDEQRSLMRVDQVYGPATFKLRQNVQLTGDDWTNFNLQDYISEAGDLSESLPGYVHRSEPNVDILICTPGRLVDHLRYTKGFTLKNLEWLVIDEADRLLNESFQEWVDVVMTSLDARKAPGAFGFSGNFLSGLGLPIQSKEPRKIVLSATMTRDVTKLNSLRLANPKLVVIGADAAATDDESGGIAPSDEQFTLPPTLKEHTVSVGDGSQKPLYLLRLLLSHIKIETKSVKPSVHDTSDSDDSDSDESSSGSDSDDASDVSSSDDSDSDSDSDSDSDTSSESSSDSEDTSEDESSDESESSDSDSESEDEKPDRQRPSQTTVLVFTKSSESASRLARLLALLEPSLSDRIGTIIKSNKSSASRKTLTAYRRGKISVIIATDRASRGLDLRSLTHVVNYDVPASITTYVHRVGRTARAGQEGSAWTLVAHREGKWFASQIAKGSDGKITRSTKVGKVQFKLDNMKEVKARYASALDLLEKEVKTGGTKASKPSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZX4</accession>
    <name>A0A8G1QZX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_304399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515428.1">
        <property type="nucleotide sequence ID" value="XM_025655359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZX4"/>
    <dbReference type="GeneID" id="37158761"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="158" mass="17492" checksum="C243BC852DF071E1" modified="2022-01-19" version="1">MGHFFVKRKSITVDLACCISYRRDRYSLVLNITARVHTLELPPSFASDSPQMICEAVILSLRGPAASSHPRLQIFLLFFRRNARGPALVGPNAGYLLSQKLCTNTKSCVRIRIPVIGYNKTDLYFLHTAVENGETCHASGLLSSLQRISLSHCSSIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R026</accession>
    <name>A0A8G1R026_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_450818</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514083.1">
        <property type="nucleotide sequence ID" value="XM_025660464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R026"/>
    <dbReference type="GeneID" id="37163866"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF41">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH56161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="249" mass="26863" checksum="3E2E67D51EFAF400" modified="2022-01-19" version="1">MPRQFFVGGNFKMNGTAESIASIIKNLNAAELDKSAEVVVSPPTLYLLPARQAAGDKIGVAAQNVFDKPNGAFTGEISVEQLRDAKIDWTIIGHSERRVILKESDEFIARKVKAAIDGGLSVIFCIGETLEEREANKTIDVVTKQLNAVAKELTKEQWAKVVVAYEPVWAIGTGKVATTAQAQEVHAAIRKWLVDAISPEAADNTRIIYGGSVSEKNCRDLAKEADVDGFLVGGASLKPAFVDIINARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R091</accession>
    <name>A0A8G1R091_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_452432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512487.1">
        <property type="nucleotide sequence ID" value="XM_025660819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R091"/>
    <dbReference type="GeneID" id="37164221"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="345" mass="40054" checksum="560DF47BC12F55C1" modified="2022-01-19" version="1">MFTRPPKVFRAFFLVVSTLLGFVTLLRLPKHPDATRNSESYHTGLSRERIDWSRFAYTQYATDRSYLCNSVMIFEALHRLGTKADLVLMYPAKFFVSENDSSIEARLLRFARDNYNVKLRPIEVIMKGGGGAPWSTSYTKLLAFNQTDYGRVLNLDSDATLLQTMDELFLLPPAPVAMPLAYWFYPEERVFTSGLMLIQPSTDEFNRVLEEIWDNPSEEYDMEIMNKLYEDNTLVIPHRPYMLLTGEFRAKNHEAYLGNTYEPWDADEVLRTAKYLHFSDWPVPKPWVAATQHVIEQTQPPCEVNPATGQRDDCHLREIWLGMYKEFMTRRQSVCGVAIQDQDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0C7</accession>
    <name>A0A8G1R0C7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_520652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515115.1">
        <property type="nucleotide sequence ID" value="XM_025665147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0C7"/>
    <dbReference type="GeneID" id="37168549"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="334" mass="36317" checksum="1C2F59801F55C26C" modified="2022-01-19" version="1">MSIQDSDAESSISSQTRTKTPKHTFPLAHPPPKSTPCLRLSPRLLLQIQQLSITSNRHRALPILEIYQPPRQGKSLPNCPRKIHGRDLYILQSDAYTDITSTPKPSSSEPPSSTYPIAAGVIYNNHNPKKSTTTTTTPPTTTTTTTTTTPEPEDEIYLPTTHQTYSATRTPRGNYRFILREKKTPSGETVIIEWRRKAPSQTRPRTASGSAVSGSTDSDTVTTPTTTTGNPCEEEGDSTTSSSDANANANVNANPRFVLCVSAIGGERAAGTDQRVRRSGLAGLEKKGLRVGGWDAKQVRFLEEVGILGAGEEKEVVTLVLTLGVYVAWMEGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0M6</accession>
    <name>A0A8G1R0M6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Subtilisin-like serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_372633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515280.1">
        <property type="nucleotide sequence ID" value="XM_025656049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0M6"/>
    <dbReference type="GeneID" id="37159451"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046536">
        <property type="entry name" value="DUF6601"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414:SF1">
        <property type="entry name" value="SUBTILISIN-LIKE SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20246">
        <property type="entry name" value="DUF6601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="38413" checksum="1D32119801EAB5D5" modified="2022-01-19" version="1">MPTKPPFSVDVSISSTFYTPAAIRDEYYTPYSPTTDISRFLQNDLSVECLNRIHKYLWLAGRPMPPRPLNYQTATSRQILLDERIDMHMVWEPSRRIHLKPLPRYLLSHQFWKSYLICKEPCPCMSNYIYCQTDRGDGVCQKKHLYECGLGLLYSYIALIERESDFAIAQDQHLMPHNVTWEMWVELVKELLENGATSPGNVNARYLFGELRLSRLNKIYMFRYGSILRGYHFTYQTYTELFYDYLTPLTATTVYVALVLTAMQVGLATKLGGNVAFQNASYGFTVFSIIGPLIILLLVGFLGFIQFISNLLATLHFKRERSAHYKLLSSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0P4</accession>
    <name>A0A8G1R0P4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_35744</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515141.1">
        <property type="nucleotide sequence ID" value="XM_025655495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0P4"/>
    <dbReference type="GeneID" id="37158897"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH57219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="516" mass="57990" checksum="B6DC39ED96D25C58" modified="2022-01-19" version="1">MEEPCYTCRRRRIRCDQSQSPCVKCATSGYQCFASRPLRWVEGLAIRGKLRGVSLATKSASPAKKAKPRKESDSSDDSLASASESALSVVRSPESQVTPLKPSISIPPTIGDFAISNLDAVSRYYLDYYNESICGLFIVYDSDRNPLRALMSLALLDRTLLKSVLALAARHRVNRHCSFRDLTVNASSDQMIANSDALRFKYQAIQGIAQALGDAKSRNKDETVASIFLLVFLDLLESGSDRWNVHLEGAKRLLEPSTPDSQAVSRHDSGQTIEDLRNFLASQIYSIETLGGTFVRPKLLSQYDLLGGPQFQETVEQSFLGCPEYLLDAIRYLSARRDTIASSECHDDSTWSYFIEDTTSMIDFIQQFDCSVWASSLPYLGTTPPRDTSSLCTLAQSYKIGALIYGKRVLGALTKECLPLEDLLQELLATIERLQNDESLYKCILWPIIIAGLECQRQEQRDSVRTYMESFWEQTKCVNVINASKIIEDRWQRCDGTEPSHWIFSIGHLGRDWLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0S7</accession>
    <name>A0A8G1R0S7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GPI-anchored cell surface glyco protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_33842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515060.1">
        <property type="nucleotide sequence ID" value="XM_025655455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0S7"/>
    <dbReference type="GeneID" id="37158857"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="907" mass="98449" checksum="36C73A5A0B464A4A" modified="2022-01-19" version="1">MVGRASVARELGSPAALSLDLTPRETRRSSSRASRKTTREPEALPSNLSHSSVSLPPTPVTTSFEEQLPSAKRRKTQRSATVDEKTSLNQESAQTPNQQGSGGPSQISNSVPKKRGRGRKSALANGETVQPATPTSNPKQQSQSTLHNFLSRTLKDRRKSLATQNPSPNPTMSTSHVSSPAMNSSASNSRKTRKSMPAKLNGFENSEKTSSVDSTSSLTSTPNAQSGKADKAPANSAASAITAEAAEAQEASTKLATSATQPRSTPRTTTARSRRAERKSRAMAATQNSKSAQSTPVSAVNSSSHKPAHSQVATRTSSRPQRSTRKSAINAASQAVDDASFETPSVSKTPFGREVADSIESTPAIDSKAEFDTMSGYDLDTPGIERSTPYGESFPFEYHADMYGNKFGLDGSNEGPGSPTASYSTTTSAARTSGRTRKPTIKAMESLESERRFRRNRAPSSKPESALKEVKGKAAVKKTRANKQANAKTAGIAQASKAGVEGNWAVLANRLLDLAAAAVAPEFEPSSEAEGWVEELRKEYMEKQEKKTETPAVQSEAELVTEAASEAQPQAEIGVEGSSQTNKFGEELVVVGEGYSWFRPNNTYGDKLLPQPPIRLKSHEQFEKDRIFGYPPRMGERNLPQDNKMPFFFENVDEVKATIKAREEARKRGIAVDRMMPAAYIQTLIAQHDETAPKDGPGEVKEAKETKEPTRKRRRGGEASETTQVPKRRRREPEPEPTPPAEPPKTLRIKLTLKGGAGAATRKRSYSEMEDQPAEMKPAETKPAEGKSQQERSSPSKILKLGLRRNYTQEMIRRTTPEDLAMGPPEPPKDMYEAFNVAPPPGPPPRNFNTAPGGRPRRRAAAALIAEFQNHAEERARRANARKRNVPSDKPDDPNTKPNGQPNGQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R108</accession>
    <name>A0A8G1R108_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytoplasmic dynein intermediate chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_450570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514469.1">
        <property type="nucleotide sequence ID" value="XM_025660406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R108"/>
    <dbReference type="GeneID" id="37163808"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000425">
        <property type="entry name" value="Cytoplasmic dynein 1 intermediate chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000414">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="497"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH56547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="679" mass="74650" checksum="F0F33EF5DE66D1A1" modified="2022-01-19" version="1">MSSAMQQRKAEILAKRAKLAELKRQRELRQKEFSQTRANTGDASEVVSPAPSRADSRAELDDLISRLVDRPGSASISHGADGLSRKGSRPNSVLSASQLSGDNTEAFSPTTRPLSQSIAVQTVGTEPFVAAPEPQPAPEPKPEVVTYSKGVQTDDLKPSGATESDDEENNGSKRDSERDEEIRRKLRKEIEEELQATQQHADNEASAEALNMRYPLRTLDDDELKAVTSSEDFLDFVERSAKVIERALDEEYDVLADYELGGVDGELEDDDEHGRKRRGIREVCQFWDERWSKKRMISDLSFSPKFPELVLAAYTKNPSAPHEPDGLVQIWNQHLHSRPEYVFHSTSDILAAKFSPFHPNLIVGGSYSGQVLLWDTRSSRAGGGAPVQKTPLTGSGHTHPVYSISIIGTQNAHNILTASTDGVVCGWTVDMLSQPQEYLELSTPPPSKTEDLAPTTMSFPQSDPTFFIVGTEEGGIYPCHRYDRAGAKAGTDHRLVYRGHKAPIMSTAFHPARGPVDLGDLMLSSSLDWSVRLWRIRPPATTAPATSAIATTQVVEPILDINREDVVYDARWSPHRPGVFSLVDGAGNLEVWDLYTDTEVPVVKTTPSKGRGGILTRSLNKVAWEEREGRRIATGGLDGVVTVFEVGKGLSGTPEDVPADEWAGMKKLVGKLEQQDRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R180</accession>
    <name>A0A8G1R180_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_422646</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514683.1">
        <property type="nucleotide sequence ID" value="XM_025657979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R180"/>
    <dbReference type="GeneID" id="37161381"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000549">
        <property type="entry name" value="ABC transporter ATP-binding protein arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="82"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="393"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="614" mass="68634" checksum="43D9187D15B87DCF" modified="2022-01-19" version="1">MVSASKAARLAKRAADGADKKKPTKGKKDDPVVDGEGGDDQPATTDEKMKEVEKLTAQMDKHGLSDRVTTGVLASLPSSRDVKVTSASLVFHGKVLITDSTLELNFGRRYGLLGENGCGKSTILKSIATREYPIPEHIDIYLLNEGAPPSELGALEWVVTEAQNQLERMEKQAEEILEKEGPDSPILEDLYDRMDKMDPSTFHTRASLILTGLGFNKQTIHKKTKDMSGGWRMRVALAKALFVKPSLLLLDDPTAHLDLEACVWLEEYLKKWERTLILVSHSMDFLNGVCTNMIDMRMKQLLYYGGNYDSYHKTRAEQETNQMKAYNKQQEEIAHIKKFIASAGTYANLVRQAKSRQKILDKMEADGFIQPVIPDRVFSFRFADVEKLPPPVLSFDDVSFSYSGKWEDTLYEHLDFGVDMDSRTALVGPNGVGKSTLLRIMTGKLSPIGGRVSRHTHLKLGMYSQHSAEQLDLTKSALEFVRDKFPEKSQDYQYWRQQLGRYGLSGESQTALMGTLSEGQKSRIVFALLAIESPNMILLDEPTNGLDIPTIDSLADAINAFSGGVVVVSHDFRLLDKIAKDIMVCENKTVTRWNGTIGEYKNHLRKKMISEGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2R5</accession>
    <name>A0A8G1R2R5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA binding protein Pym</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_306658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515508.1">
        <property type="nucleotide sequence ID" value="XM_025655381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2R5"/>
    <dbReference type="GeneID" id="37158783"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="2">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="220" mass="24125" checksum="15A80218FC8D0652" modified="2022-01-19" version="1">MASNKPGAVSSSGITTNESTGERYIPSSVRADGSKRREIRVRPGYRPPEDVELYKTRAAEAWKNRGKGGVPGADGLKDDEDTSANKAGGATNNKNAKRREARKKAKATQDGATNGKDVTRIENWRAGAPEEAKRQSNGAEKDAAQTEEAVDPEAEKEKKARNLKKKLRQARDLRDKKAQGEALLPEQLEKVIKIQELIRQLDSLGFDSNGDKKEATEVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2Y9</accession>
    <name>A0A8G1R2Y9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">OPA3-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_419161</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516386.1">
        <property type="nucleotide sequence ID" value="XM_025657845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2Y9"/>
    <dbReference type="GeneID" id="37161247"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH58464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31210" checksum="3A985912416E00F5" modified="2022-01-19" version="1">MSLTLKLSSLVIRTLSKPIANQIKAQAREHERFRRICVSMAQGLHRIDMRLRLGNIRDNAASQKRAAAERELRKHKPTSPTVKTEVEAKAEEEAIAKAKAAAEEAAKPAPKPHIRPLSESKAIESGATFISETFLFIVAGGLIVFESWRSRRKETTRREDVETRLAELEQSEKAARLALLALEKELLQQKAKHGELPKSSSRILPREVWDVNQEDEVKPAEEPGLLSWITSYLPWGESPEQRAESVIKESKSAAKPSVDAPTSPASKPAEPEAKAPEPKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3D0</accession>
    <name>A0A8G1R3D0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MHYT domain signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_280127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516626.1">
        <property type="nucleotide sequence ID" value="XM_025655189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3D0"/>
    <dbReference type="GeneID" id="37158591"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="2">
        <location>
            <begin position="17"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="791" mass="87397" checksum="F6BBC672B4A38EBD" modified="2022-01-19" version="1">MLLTDRAPHGDNVHVSYMGGFIFLAYVVSVMGCTTTLELLHRRTSRSGLYNWYLLLTSSITMGGVGIWCMHYIGNRAIVLGNGDAQLQIIYSMTFTGVSFVLPVVVLLVAFYSIGASEKAGYLRILTGGILTGGAVCGMHYIGQLGISNYRCSYRIANIIGATIIAVFASTVALTVFFRWRATWTDSWWRRGICGCVLALAVSGMHWTAAVGTYYYNHDTTMKHNGQLSRSQVVIISSVLACAACGVLTACAVVAGGNRRRLNIQARQLVLTCAFFDQSGRIMVTPHALLPSRKIVDRYVGKTFNDDDLTRSHPAFLWAYRASRHWNLVKDVVPFMRSRIETDEEAAEHFLAKGEALDQENELQNDFDELFKRHFCVTAQDLADEVRQPLPALGKLYDDVLITTAPTSRFSRAMGYSRLNNSKGQMLFTVRHLDKQEANRLAAAGFRFTTIENVTSALSSRMHIPLPVLGEHLKDMRDYATGGRNYEPGVHLVSFVMRPTISDHFEVLTAKGTGNPLPSSTLPIKRINIQHLDLISHMEGWTISTCLSWLKSEAAQSNKEIDDFREQLIHAMTSLESALPPDINMASKFSAKPLIAPCRALSDSDTSNSILLPFCAVGNLDTQVSNPDFTFMPLRLFRAQQQLNDTNIGGDGFAKELGRELYYSNARSSSATEADITPSIRSVLKLWPRKHMDPAHGDLSQETLTELSQLGDIMVRKEVKVDVAKLSTRSLESTKHASHATVVAGDLATSSYVDELYNLCYSPGVRLRPNTAITRNSMARSSVARSSVATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3R9</accession>
    <name>A0A8G1R3R9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_448751</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516650.1">
        <property type="nucleotide sequence ID" value="XM_025660008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3R9"/>
    <dbReference type="GeneID" id="37163410"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001872">
        <property type="entry name" value="PAXNEB protein superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="364"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH58728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="393" mass="42209" checksum="8ACEC717EC1B3622" modified="2022-01-19" version="1">MSFRKRNIGLSAGADRTGAVNANAQPQQPPATPELTPGVRPSPDDGRPTTSTGTPSLDNLLAGHGGLPIGKTLLIEENGTTDFAGALLRYYAAEGVVQDQKIHVVGMPEQWGRSLPGLLGPADAVDDKQDKRKGERMKIAWRYERLGEFGAGIAGSRAPSGDQSQSATDPNVDKRPAFCHAFDLTKRLTHPSIANVNYIPLAPSNEPLFVSIHKRLQAAIASCPPNTVHRILIPSLLNPTIYPPDSCQPDNLLPFLHSLRALMSAQGARVTAMITLPLSLFPRATGLVRWMELLSDGVIELCPFPHSSDALATSGAATSQEEPPQGMLKVHRLPVLHERGGGSDQNIGQDWAFTLSRKRFEIKPFSLPPAEGDKEGQDAAVTGAMPKKADLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3W4</accession>
    <name>A0A8G1R3W4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_469310</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515192.1">
        <property type="nucleotide sequence ID" value="XM_025662323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3W4"/>
    <dbReference type="GeneID" id="37165725"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="644"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="785"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH57270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="850" mass="96953" checksum="CDFC1587E3DF41BE" modified="2022-01-19" version="1">MAPRDTLFRSSEMSLTQLYIANEIGREVVSALGELGQVQFRDLNPDTNAFQRTFTKEIRRLDNVERQLRYFHAQMDKASIPMRSSSEFSDTLAAPLASEIDELAERSESLEQRIASLNDSYETLKKREVELTEWRWVLREAGGFFDRAHSHTEEIRQSFDNDEAPLLRDVEQQSRGPNGDAQGQQSFLEMNIGFVAGVIPRDRIGAFERILWRTLRGNLYMNQSEIPEAIIDPTTNEESHKNVFVIFAHGKSIIAKIRKISESLGASLYNVDENSELRRDQIHEVNTRLGDVGNVLRNTKNTLDAELTQIARSLAAWMIIVKKEKAVYDTLNKFSYDQARKTLIAEAWCPTNSLGLIKSTLQDVNDRAGLSVPTIVNQIRTNKTPPTYMRTNKFTQAFQTIVDAYGISKYSEANPGLYTIVTFPFLFAVMFGDFGHGALMTMAAAAMIFWERKLAKTKLDELTYMAFYGRYIMLMMGLFSMYTGLLYNDIFSKSFTVFPSQWQWPDDIKQGQTVEASLKTGYRFPFGLDWNWHEAENSLLFTNSLKMKMSICLGWAHMTYALCLQYVNARHFKSKVDVIGNFIPGMIFFQSIFGYLVLTIIYKWSVDWNARGQSPPGLLNMLIFMFLSPGTVEEQLYPGQASVQVLLLLLAVIQVPIMLFFKPFYLRWEHNRARALGYRGLGEPSRISALEDDADGGRDSMASDGEGVAMIAQDLGDEEHEEFDFGEIMIHQVIHTIEFCLNCISHTASYLRLWALSLAHQQLSIVLWDMTIGGAFEQESPTMRVIMIVVTFYLWFTLTIAILCVMEGTSAMLHSLRLHWVEAMSKHFMGDGIPFTPFSFQTLLEEDPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4C1</accession>
    <name>A0A8G1R4C1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_394996</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517245.1">
        <property type="nucleotide sequence ID" value="XM_025656940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4C1"/>
    <dbReference type="GeneID" id="37160342"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF25">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH59323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="531" mass="57197" checksum="C5190A0D766B1401" modified="2022-01-19" version="1">MASYELKNRASSANREVTGSDSGARDDLALARLGKKAVLKRNFGILSIIGLSCTILGTWEGILSTFTIPLENGGSAGAVYSFIFAWTGTACCFVLLSEMASMAPTSGGQYHWCAMLAPYKHMKFLSYITGWLTVIGWQAAFASSSYMAGTEILGAIILGRNSFSSQPYQGTLLMWAVVVVALIVNIIGGKFLPRLETFILMIHILGYFGVLIPMTYMSDHKSTESVFKDFTNGGNLYTDGISFFVGMTGCVFAFAGGDAAVHMAEEVNHATVVIPRAILLSVAINGTLGFTMLIATLFCMGSVDAALESPTGYPFMEIFQQATGSVAGALGLSSILVIVGICAALAMLTATSRQFWSFARDRGVPGWRVWSHVSNRTFLPTYSILLTMTICCLLGLINIGSAVALNDVVSMAVSGLYSSYLIVAVLLLWRRCSGAISNYNASDDTVVNVPGAKLMWGPFRVPGVWGILINTYAVIYIVIVIFFSYWPTELPVTVTNMNYSVVGTMGVVILAIIYYALRARHVYTGPVIEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4D5</accession>
    <name>A0A8G1R4D5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_292883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515971.1">
        <property type="nucleotide sequence ID" value="XM_025655286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4D5"/>
    <dbReference type="GeneID" id="37158688"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034643101" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="12028" checksum="453D2AFB5CE5F38F" modified="2022-01-19" version="1">MYSFLIMFSASSVLITFSGAGPERSFAFLISQQASWAFHLLLCPDHFSFHFVHTWSGFNVVMPESQTDGDIRLFSWILLDWRLHILLEAILSCSTLIMVPLSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R547</accession>
    <name>A0A8G1R547_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hybrid NRPS/PKS enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_447377</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517385.1">
        <property type="nucleotide sequence ID" value="XM_025659709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R547"/>
    <dbReference type="GeneID" id="37163111"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="529"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH59463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1276" mass="137962" checksum="477D0D6218704B9F" modified="2022-01-19" version="1">MTIIDVTKNLSALFSKQVQATPDALALEDDKTTYTYAELDRAVDALTRRLHHYRVGRDTLVGVLLPRSSDYVIACLAALRAGGAFLVLELAYPPELLDDVIRDGNPAVIITCRAEVGKIKADVPLISLDEPATETNGVSDLPPPPADDDLDRLAFVSYSSGTTGKPKGIANPHRAPVLSYNLRFGVQDLTPNDRVACNVFFIWEILRPLLRGAAVVAVPDDISYDPAALVDLLAAKRITETLMTPTLLATVLARHPHIGSRLPHLRTLWFNGEVVTTDLARRASQALPNTRLLNCYSACETHEIACGDIREMLDEKALYCPVGPPIDPKNTHILDDNRQPVENGVSGELYVAGPLLARGYLNLPETTAKAFTENPFDSTPGSRLYRTGDLARRLPSGLLEITGRVGSMIKLRGYSVVPAKVEYEITKNLAVRHCAVVAHGEGLERQLVAYIVRDKDHAPDRPVVEINEAGNSPGARRTLTQVLAHYMIPSLWVELEELPTHDVTGKVDLKRLPPPRTADHVNGNGKPVEKDLIGIDQVAAIWAVALKTARNLLKPSDDFFDLGGHSLSLADLSSRMSRHFGFRVPIARLAENATLAGHLQTVRDIRDGHTAAVQADLPAVLRADATLDEDIRPSKAAIRSVTDADTVLLTGVTGFLGAFLLHDLLESTSAHIICLVRFTDPADDDQPGGVARIRRNLLDLGLWRDSIMERVEILPGNLSRTRFGLSPEAFDELAARVQVIVHAAATVNLVYPYAALRGPNVGGTREVLRLACKGGATVQYVSTNGVLPPSGEKGWPEDAMLPVDDVPDKLLDGYGQTKWVAEQLVLEAGRRGLPVKIHRAGTISGHSQTGAANAWDLLSALFVESIKLGYAPEVEGWRAEMTPVDFVSKAIVHLASQTHAEQTVFHLGDPNPVDTRAVFASLNELGYPTKSLAWDDWVSLWNEKRSAVKGGDGGFTVDILRSGMPTVEFLRGIVVLDNAATRPFRAVVERPKVDRALLETYTRHWFARGWLPRPPLRQQGLNGTAKPAIKGPLSGKVAVVTGASSGIGAAVAAALGREGCHVALAARRLDALESLKGRITAHGGKVIARKTDVTSKEQVDALFKAANDELGPVDIIVSCAGVMYFTMMANVQTEEWERTVDVNCKGLLHCLSASVPGMLSRGRGHIVAISSDAGRKVFPGLGVYSASKFFVEATLQSLRLETAGMGLRVTSVQPGNTATDLLGMSTDAEAVKKYGEPSGAQILEPDNVADSIIYALRQPAHVSVNEVLIEPRDEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R596</accession>
    <name>A0A8G1R596_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_420388</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515912.1">
        <property type="nucleotide sequence ID" value="XM_025657893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R596"/>
    <dbReference type="GeneID" id="37161295"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="474"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH57990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="569" mass="61387" checksum="1A158D98DC75953A" modified="2022-01-19" version="1">MSLSMPGPSQAGLFKPGYQSHDAEDGAVIRNIEACQAIAQTVLTSLGPYGRNKIVINHLQKMILTSDAATILRELDVVHPAAKLLVMASQQQDAEMGDGTNMVIILAGELLKKAEELLRMGLKTSDITQGYEKAQNFALQVLEGLEVDRLQDLRSQTELSKALRTVVASKQSGTEDILASLVAEAVLAVLPKNPVNFNVDNVRVVKIMGGSLEQSRVVKGMVLGREPDGVVKKAQKAKVGVFSCPIDISQTETKGTVLLKNAQEMLDFSKGEEERLEAAIKELYDSGLRVLVCGSTIGDLAMHYLNRFNILVIKILSKFELRRLCRVVGATPLARLGAPMPDEMGSIDVVETTEIGGDRVTVFRQEDSNAVTRTSTIVLRGATQNHLDDVERAIDDGVNAVKAITKDPRLVPGAGATEIQLVEKISAFADRTPGLPQHAIRKYAEAFEVIPRTLAESAGLDATEVLSRLYTAHHHTSANGESSEESEEEGSSEEEPYWTTGVDLEVGPSSTGTLDTVDEGILDLLASKSWAIRLASESARTVLSVDQIIVARQAGGPKPPGPNPNWDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5B3</accession>
    <name>A0A8G1R5B3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_476388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517691.1">
        <property type="nucleotide sequence ID" value="XM_025662776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5B3"/>
    <dbReference type="GeneID" id="37166178"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="406" mass="46007" checksum="DC1503D7CA96C931" modified="2022-01-19" version="1">MSSIFCCPSINPYRPQKLDHEDKFEAFMQWTKLESSPTLDLASVGADTVPYAVQLVRQVNFGPQESIRYFAPAGTGSQFVEVAEGDLIDWNFEKLNSCEKHNKFYEVNLYQRNPTISHHWRVNLARPSRDIDLALRTKEHQMKEIRVGIESSEYKADLSQGEASVQKQHDPIARSLEEIPAKGTDSKSPEMNPPAADPDNLALKSVLRFLLPPDRISLRSNHLLSLLCLDWLNQKFDLGLELESSWTSGLTSSNMIVFLCGCFDSSVDDEVNVAEVEALVIPAMKESRDKLKQIVTRILDYGIGVDWVTKHGCHVRRVLDSFPSADFLEESLRANEKYEGGWSHQDTSVIQSALNEEPDEESSVWSSPRDTYYPQHEIYDYGYGSESPKDFTACDKECGYCGHCDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5E8</accession>
    <name>A0A8G1R5E8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_367597</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517444.1">
        <property type="nucleotide sequence ID" value="XM_025655822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5E8"/>
    <dbReference type="GeneID" id="37159224"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="128"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH59522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="438" mass="49080" checksum="81AD04A279929609" modified="2022-01-19" version="1">MAGDKVKDMHVAIVGLALAMGLHKQGVPFTVYEEEAQYSTVGAGIGFGTNGDLALDMIEEGFLSKFERFCMGNKPEDAQNIFFEGMLLKEGLGLKEPWYGKSSWGHPDYVRRAAHRNDVLQTMTSFIPIEKVRFSKRLANIQQHPNKVTLTFADGDTAEASILVGADGIKSVVREHVLSPLYPSQVNPVYAGSYCYRGVIPIAKGKEIFGDLTDVAKMYLGEKRCCVHYLISGGEELNFLLCVADDKPWALPNAVTQKVTYETMMSDFNDPSIDNRFRRLLRKAKPIRWGLFHHRYTSTYYRDRVVLLGDSAHASLPFQAAGAGQGLEDALVLSNVIAKICRNVPGSDLLHPYIQAGFAGYDQVRRPRAQKQLERAHEMATMLYYEHPETGKDIYKMLGKLQAGWFEWLWFRDLGRDVEEAGRGVDEILGRVGGRCKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5Y2</accession>
    <name>A0A8G1R5Y2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_446740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518085.1">
        <property type="nucleotide sequence ID" value="XM_025659569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5Y2"/>
    <dbReference type="GeneID" id="37162971"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736">
        <property type="entry name" value="ADP-RIBOSE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736:SF1">
        <property type="entry name" value="DIHYDRONEOPTERIN TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="213" mass="23937" checksum="F142252A887A7A8B" modified="2022-01-19" version="1">MNSTTTTTTIQEIKISPHLLSKYPFLIHPLSSLPTTHYPTYTDFGVGAYIFTTHQQNSKPHLLLLHRSPTDSYPLHWESPGGGADLSLDDTLLRALCREVLEETGLQVTKVVDLVAVDEWKKPLPGLGQGEKKVIKWGFLVETASVEEVMLNPEEHCAFKWVDEGEVKAAIDEASGMKFIGDQGRNLVRAFEVYRRWYTSSEEEEEGEGKDTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R693</accession>
    <name>A0A8G1R693_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_485919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517368.1">
        <property type="nucleotide sequence ID" value="XM_025663352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R693"/>
    <dbReference type="GeneID" id="37166754"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="212" mass="24162" checksum="D2BC6C88D9177805" modified="2022-01-19" version="1">MATSHRSTGFYALLRQKGLLVPPPLWTSCHLDRLGCQFEEIRSLPGSAAETHTSTLSSVEPKSKNDSGSDAARLARCGAVLIKLFTLIDILDYEGSPFETRKTGRINFYFAGRVVHRLECATFWRRVQDTQSEHSAADLLVGYLDYNDLAGYRRECDQERRARRLGHTPVVHKSAGENWLLTRDWKSDPYLVCVLLSLGQLQRRLRHPKYQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6E0</accession>
    <name>A0A8G1R6E0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Basic proline-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_366485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518325.1">
        <property type="nucleotide sequence ID" value="XM_025655781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6E0"/>
    <dbReference type="GeneID" id="37159183"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="35843" checksum="9311FB7FE744995D" modified="2022-01-19" version="1">MEASHPPPEGIMLPPSPVGSSDSFDSTSSGSAAEQPGEAKCSDNVMITLSLTPDPPVQTPTRLPFARSHFRSRSMVEVPGLPPMTRAHSSPGLDSRGRYIFVNGCGASTNVGDPAAKRYLPLQVTTGDGLESRMVPLNISETISEHAELDTNLVSSPSQIDYHPTSPGFSHTLPRVNRRRPSSPLHFQSPSSSVHSVGSPSGHSSPVIYNMRYNESYPGYSASSTSSIPSTPTSLRSRSPSISSLETIPDIPDAEAAAIEADRIAALKAAADKADEAEAASSGNRRRGASDASGPSSGLMTMRAGSVGYGPRADKRKRWSVCGAERRQDLDLETIWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6P1</accession>
    <name>A0A8G1R6P1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_447142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518490.1">
        <property type="nucleotide sequence ID" value="XM_025659658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6P1"/>
    <dbReference type="GeneID" id="37163060"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="495" mass="53938" checksum="764B65B8119D9BCA" modified="2022-01-19" version="1">MYSTTAPLDLDYLNEQLLPRRYESEEEETSESEYGAHDHAFSPIKTAGPFDSDTSADELSNVNSPESPVDKSSFARLLSAYPSGKQSRPVSMDTVKRSSGTTFVPDSYIFDDDDDVIIELPSPSATSPLQSPIFLQPTVYQPPASPLSQQSRSPSPALSESDEETDVLVAEQVKFVEPCAKPNLILISPVTDGSVVEEPEPMSAVSAVSADVPDRFPPGQGLYSLNQGTKSQPLLSDKRPDYLGHIKRGSLQLHSKYAKQAPKRADTDPFTMPRALADVPETAQPMTMRSRAMTWNRPQTSADSASNRGPKAGLLRRPPSMQSVGGAGGGYSLFPSTRRTPAYPSDEYHARSTSVSHSIASSDMSQPPSRTSSPAPYYSSPTFNRHRSGSSYSVSSVPGNISQRPPLRNSIMKSSTASSVYSASSLRSEVESVHSLEPRETAETEVAKTARRKKSFRRSKQPKLESTTTEPLPTTPKSFMGFMLRGRRKSTIQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6S0</accession>
    <name>A0A8G1R6S0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA ligase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_416206</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518535.1">
        <property type="nucleotide sequence ID" value="XM_025657723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6S0"/>
    <dbReference type="GeneID" id="37161125"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08039">
        <property type="entry name" value="Adenylation_DNA_ligase_Fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF2">
        <property type="entry name" value="ATP DEPENDENT DNA LIGASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02430)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="7">
        <location>
            <begin position="393"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="673"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="673"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="774"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH60613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1053" mass="118757" checksum="6982236E6C330826" modified="2022-01-19" version="1">MGFKFAHLCDLLSTLEDNRVLKAAHEAKVVNPDIRAVSRWFAQNEKRIRDKDTDQLALLSCMFPEKRTDRVYWLQDTSLAKIIARCLLLGCSRRQELERWRVSGGVDLGQCVENVMRQAENHVTNGQDVTVEEIDKALAEIASRCRFSGPRVRRQRTAVKVDQTLSPLYRRLSSRDAKWLTRMILKSYSPVSLPVNIILKRFHFLLPHLLLFQDSFERALSVLGSSPIKHFPPQPDAALAKDLGIIALGHLSPAVGVKIGRPEYYKARSIKHCCRMIGNRRMSIERKYDGEYCQIHIDLSKDSDWIQIFSKSGKDSTGDRAGIHQVISESLKLRRPGCKISQRCILEGELLVWSDKHGSIADFHKLRKFISRSGTFIGTQSDSPPQPYEHLMIVFFDILLMDDNVCLRLPHRERRLLLKDTIEPIPGRADISEQWVVDFSHHGGQSRLESIFNKGITERWEGFVLKASEDPYFTIFSDDKDNPSFGRWIKLKKDYIPGLGDTVDLAIIGARYNSRDAMAIKQVKKLSWTEFFIGCLVNKEMVVQSGAIPKFRVLDVINHHCMHVRFMQFLNQFGGFCARSPDSEHGFILEYGESVANPMDVVFKTPFVVEMLGSGFEKPSGARYYTLRFPRILKVLSDRSFEDAASYRELQLLAETARSALDEDPGNHEYEAAKRMKLRDRSECTPDRSPSLQTTQSPFLQSSTTAEDNSGPGAFVSPSNNALNAPDALLGSARQTKRRRESSAMQRTIPIHVDLNRDPSPPTAQSVRGKYLTDNANLSSHAAGQRKNSTQTTGSSDAEKAFRPSQMPGPSSGLDKLQKHSESLHKLIDRQIESNVTLETCSNRPSGNETVAPRLCQKATQRILSPLLHSSIYVHHDISDDMVVSQPIPNAWKIAPTLNEFVRKLTRPDTQCRPRTSNQHAVPHGTAYGLVMIPGKTDALCTVLPDLIRAIADTLQSYHINSHHHGGKVMILDSSFLKLNISSDDTRFCLHQTLEGISKAFFYACVSWTFDGPPGHDSSEDQARECDALYTRPKITVSFDRREVGLLGEKQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R710</accession>
    <name>A0A8G1R710_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rad4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_417375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517758.1">
        <property type="nucleotide sequence ID" value="XM_025657774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R710"/>
    <dbReference type="GeneID" id="37161176"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="519"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="578"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="648"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="763"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="792"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="869"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH59836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="944" mass="106166" checksum="ACD4128EB6D3DE7F" modified="2022-01-19" version="1">MPPYVPRKRLSSEDPPAAKRRHATPPIAAVIEDTDTESSLSDVPEEKETPQVPDGSDEESSDSDEVDWEDAIESNANATPVTPSILNPDQHQDLELTLDKNEIHLTDLLEGKKGPSKIERQIRIQTHCLHVQFLLHHNAIRNVWANDSQLHEILRRKLPQPIHKEVKKWRIASGLEAPEPPPEKKSKKGKGKQRRQSERDWAEGSSRLEPGQPDMSSGDPIIILLKVLAAYWKSKFKITAPGLRKHGYRPMAQLEAQIKSFHKDDHDPEKHGERIANIDEFRHAAENMQGSRDVGAQLFTALLRALDIEARLVASLQPLGFGWTKSETYTTKPSADTEPSTENAETEDAIDMESDSSEDDTKPARSKYFNKYDEDLPFPIYWTEVASPITHQIIPVDPLILRNPVATTPELQAAFEPRGGKAEKAKQVICYVVAYSSDKTAKDVTTRYLRRRTWPGKTKGYRIPVEKIPIPGRKGKFYEIDWFRVILRVYQRPTPLRTAVDDLEDTKDLLPNQPERKPGKEGDTLQSLRTSTEFVLERFLRREEALKPGARHVRTFKTGKGAKAKEEKVFRRKDVLKCLSAESWHKEGRRPKAGEMPLKRVPIRAVTLLRKREVDEFERQNGEKPKQGLYAIHQTEYIIPDPICDGVIPKNEYGNIDCFVPSMVPRGAVHIPWPGTVRVCKKLGVDYAEAVTGFEFGSKMAVPVIQGVVVAEENEDLVKDAWLADDAEKRKREQRKAEARILQTWRKFLFGLRIKQRVQEEYGGNADEGVDHERDAHNPFTNRRGRLPDQDASASASASAPAPDEHDDEVHGGGFLLPGEDEDEDVDRGGGFLLPGQEGDDHDDGGLIVDHHEQQHQHVPTEPVTPEAVDAEIADSDDDEEGDDDDGKVENPISLSSDSEDLSSPVEIPDSEGSVAESESEYEPVAPPPPPPTTRRSTRRSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7K5</accession>
    <name>A0A8G1R7K5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin NUP37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_438401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516132.1">
        <property type="nucleotide sequence ID" value="XM_025658667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7K5"/>
    <dbReference type="GeneID" id="37162069"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="71712" checksum="3CC78C99B878D60E" modified="2022-01-19" version="1">MPSFPSRPLVRPRDDGLQLSYQLPHRVHAAQGYPLLAPNGSSIVVYGYETGLKVVWRGGRQFSAEKPSAPKVDKPQKASNANDDAVMIIDSDDESMAETQHTQQDEEPTYQFEEDETEVDPFHPYDDVLRQIDIPLGSRVLELAVPRVLPETARSSLDPFPPVLKKDIIVAAVCADYSTRIVTLPLLPPHPTQSDFGIQSISISGGVSHQEIPRGVSIAFTYQELDQQDQDTPSSRGSSRSAAGRWDLLVATHSAESSGLLIIHRIPVAEDEKARDTVYHLCDDEIETKRRHLPSPAVNISFNPSGYPALRHSTLLVAFHSGCVKVYSCFSTKPLKASRRSSGAQSEFETVDTEGRWLISLYPGFEQSASGLPRRKIITHTEWVLGGRAILVLTSDGEWGVWDLEGAGPGTIKGPLQRQSSVQGVTGGSLTTFSVSGRILSPLPGASRSETSGPSFEQRPKFAPLTPSTKRLREDTLLKGASVGTATPSLSGGISVYQTNSWRDALPDESILLQHGNQSAVIPSLLSLWRNAVKASGTFDSSNRCRVSPLQDITLVGERLKGIGHLPAAPRSTRTQPFDMLLTAEHRLVILAPRLTEPAPAPVTEYIPEPPTRETDQQMLQRGQLGVEGMDRLLSGMASTNRSLRIGSPVKRTRVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8I4</accession>
    <name>A0A8G1R8I4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_517351</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519064.1">
        <property type="nucleotide sequence ID" value="XM_025664898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8I4"/>
    <dbReference type="GeneID" id="37168300"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="67"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="172" mass="18284" checksum="FCE9B7BF783A91B3" modified="2022-01-19" version="1">MSFAARSLRPFASRVLSQKLPLSSVCRAAPASFPRGSVRSFSQSPLSQLKKYTESHEWIELAEDGKTAKIGITKYAANSLGDVVFVELPEVDLEVSAGEPVGAVESVKSASDVLSPVSGVVTQGNAVLDDNAKFINQSPEGDAWIAEIKVNDAAELDGLLDEAAYKATIDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8Y8</accession>
    <name>A0A8G1R8Y8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_257368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH60045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517967.1">
        <property type="nucleotide sequence ID" value="XM_025654998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8Y8"/>
    <dbReference type="GeneID" id="37158400"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="64" mass="7317" checksum="230D09001FEB137B" modified="2022-01-19" version="1">MRAHTHTRTHTLYSIIYSCKRTENDTTLLKSAGIGLGLRSPFQSFGTSQRYDTKQPSTFSHRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9W5</accession>
    <name>A0A8G1R9W5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SNARE complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_454861</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520693.1">
        <property type="nucleotide sequence ID" value="XM_025661348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9W5"/>
    <dbReference type="GeneID" id="37164750"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097576">
        <property type="term" value="P:vacuole fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06897">
        <property type="entry name" value="PX_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15858">
        <property type="entry name" value="SNARE_VAM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000052">
        <property type="entry name" value="Putative SNARE complex subunit (Vam7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000058">
        <property type="entry name" value="VAM7p Vacuolar SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="7">
        <location>
            <begin position="442"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="780"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="647"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="679"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH62771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="843" mass="92644" checksum="E2498A08D820F159" modified="2022-01-19" version="1">MPDKRKPSGSVTGYSPYAKRSRPSYAEEDDEEEAQPTVTPYERPRNHPVYGQKSAFPGLDVAGDDELFYGPAEDGLEYLRMVRSEANSLPFLFTAPQSTETTAATEQEQEQEQQQEQNGEEPQQQQEEVKDISEPVPEGVVVDGVYFVPPTSKTNTAAAPAANVADEGISDAQSSYYNLLHHRFLLLRSILKCTPPSEAIAGLDESHPISLPRHSRNARKEWRRLLLAVDPQTVQLACMDMESVLGVLEIMARLMSENVRSGDAQRVRRIGAWAWGLLGKCRDVGQLGTEEVGEIRDLGKRAVKILRKMREEDEKKMQEGDGSDEEDAEDETGGNAAEGEDGAQQVDGSSDDQDHDMQDVEEEKPATAEELEAAKARLQAKLADGEEQPAVTEPEVNNEEPPNEAATQTRAMLDMIITVIGDKDSYVQTTPKVSENPTIMPPTTLEISIPTTSISATQPPYTLYNITLRLPLRSFTISKRYSDFTTFHNTLTSQTNAPPPAPLPPKSWFQNTINNATLRESRREALEAYLRAINESDDPRWRNSPAWRAFLNLPSLPSNNNSTGGGNGASTRLHAAITDPGDSEGGGITDPILWLDCFRDMKGHLHDARLYLTRRDQETTPQRQHESSAKAKSELVRAGGLIGSLESGLRNLSNTSTSGGEGNNAGGGSRPGSKLGRRNTATTATAWSVSGNNTLGEGEMRRRKDLLINARKEKDGLEDLLNAMAAKSRIDSAVASIQDKEALMGTQGGKKAIRSSGRVLGRETERTRELDNSGVVQLQKQMMQDQDVVVDELMRIVNRQKELGIAINNELQVQNELLNLADEDATRLGGKIDIGKKRIGRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB48</accession>
    <name>A0A8G1RB48_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_443974</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520550.1">
        <property type="nucleotide sequence ID" value="XM_025658913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB48"/>
    <dbReference type="GeneID" id="37162315"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="12">
        <location>
            <begin position="120"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="395"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="416"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH62628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="467" mass="52126" checksum="3D4B5B31C1D76C7A" modified="2022-01-19" version="1">MSSFRPQTLRTAVPYGQSKPTLLGTRSWRPATAITGVAAARFNSTSSAPSSTTPSVPAASEVSLAPQGEVNLNDLTAADINAIPEQIGYLKQLGLDFGWGFSSMIEWSVEHFHIMGGLPWWGAIVATGLFIRLGLLYPTLMAADTSTKLNNIKHLTTPLRTEMVQANYKNDLMEATRKRAELSQLHKDHGIKPWKAMIPMIHIPFGFGCYRVVNNMCSLPVPGLTTEHVGWLQDLTVSDPYYILPLIGSVILHHTLKKGGETGMNQMKDSAFKNIFLYGMPAISFLFMANFPGALQLYFMTTSVFALGQTYLLSSSTFRRMAGITLVDHNVPKPDEQQKNDNHGLRLINEVPDKEAAQKAAEEAERERLSLIDRTIGQVKETGSKLKDEMQKKVEEYRGSGPTKNADGTVSAGPRLSEKDRKLAEDYERRRAEEEAWKREERNHARREAHLRAMELQRQRAAQASRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBP3</accession>
    <name>A0A8G1RBP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspergillopepsin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_494996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521141.1">
        <property type="nucleotide sequence ID" value="XM_025663894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBP3"/>
    <dbReference type="GeneID" id="37167296"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034178603" evidence="2">
        <location>
            <begin position="19"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="264" mass="27355" checksum="FDA8F9AE81D8734B" modified="2022-01-19" version="1">MKFTAAIATAILASVAVAAPERGLEARLKARGTGKGSRPLQAVARPASTKNQTNVEYSSNWSGAVLVEPPSAAATYTAVTGTFTVPEPTGNSGGSQAASAWVGIDGDTYGNAILQTGVDFTVTDGEASFDAWYEWYPDYAYDFSGIDISAGDEIVAIVESYTSTTGIAIIENKSTGQKVTKELSSSSSLGGQNAEWIVEDFEENGSLVDLVDFGTVTFTGAVAKAAGGQSVGLTDATIIEIEENGKVVTDVTIDSASEVTITYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCB0</accession>
    <name>A0A8G1RCB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_444390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520969.1">
        <property type="nucleotide sequence ID" value="XM_025659004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCB0"/>
    <dbReference type="GeneID" id="37162406"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000190">
        <property type="entry name" value="Sugar transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000276">
        <property type="entry name" value="Sugar transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="68"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH63047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="512" mass="56158" checksum="444CE2736FAE0FBE" modified="2022-01-19" version="1">MSHYYEGDKPSTGVPVPVQLSAADEDEQSTMSPIKYMATRLTTLVPPMNPAPNPFKALMLLNRKQWLFFGVAFAGWTWDAFDFFTVSLTATDLAKTFDKSVTDITWGITLVLMLRSVGAITFGVAADRWGRKWPFIVNNLLFVVLELGTGFCQTYKQFLACRALFGIAMGGLYGNAAATALEDCPMEARGIVSGLLQQGYAFGYLLATAFARGLVNTTSHGWRPLYWFGACPPVLIIIYRMFLPETDTFLQRQATREHVRGGVTTTFLSEGNTALKRHWLLLIYLVLLMAGFNFMSHGSQDLYPTMLENQFNFSADAVTVTQVVANLGALTGGTTCGWASQIFGRRFSIVFICIIGGALLYPYTFVTNHSVMAAAFFEQFCVQGAWGVIPIHLMELSPGAIRTFAVGTAYQLGNLVSSASSTIESTIGERFPLPPTEDGTKRYQYGKVICIFMGCVYGYTILVTLIGPERLGRKFDVAHDGDMAVVAAQRGTDGEVEVEGDPEKGTSRMVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCE6</accession>
    <name>A0A8G1RCE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetylornithine transaminase</fullName>
            <ecNumber evidence="5">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_444583</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521210.1">
        <property type="nucleotide sequence ID" value="XM_025659049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCE6"/>
    <dbReference type="GeneID" id="37162451"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002325">
        <property type="entry name" value="PRK01278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH63288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="474" mass="50947" checksum="293201422EFF1B9D" modified="2022-01-19" version="1">MAFARLAARRLPVARRLVPSIDSLPQQRFFSISQHVKSQNKAAVPNPDPAADSVSVAFVNDQSPYMLPTYVRPAPVMVKGQGCYLWDMENRKYLDLTAGIAVNSLGHCDPEVAQIIAEQAEVLVHASNLYYNAWTGALSKLLIDVTKKSGAMRDASQVFICNSGTEANEAAIKFSRKVGRSLDPSGAKHEVVSFHNSFHGRTMGALSATPNPKYQTPFSPMLPGFKYGNYNDVAQLETLVTEKTCGVIVEPIQGEGGINVATPEFLVALRKRCDEVGAVLIFDEIQCGLSRTGSFWAHAHPSLAPASGEAAHPDILTSAKALGNGIPIGATIVSEKAVAKHIKPGDHGTTYGGNPLVCRVAHHIVNRLADPELQKSVETKGDLLVSGFKDLQKKYPNVISEIRGRGLIRGVQLSPEFVSKAGDLVGAARERGMLIITAGEGCIRFVPPLTITEEQIKSGLKILEQALEAVVAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCK5</accession>
    <name>A0A8G1RCK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thymine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_456239</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520156.1">
        <property type="nucleotide sequence ID" value="XM_025661430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCK5"/>
    <dbReference type="GeneID" id="37164832"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="180"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH62234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="335" mass="38729" checksum="26F62BCEBA2BA2A0" modified="2022-01-19" version="1">MQIPVVDFSQWYNSQDASSRQQVAHALVKACQDVGFVYIVNHSLPGSVLDETFEWMRRFFELSSEDKMRAPHPEGWAVHRGYSWPGLEKVSQVMSTGDDEDARKKLREVPDVKEIYDIGSEENTFQPNQWIPKETLPGYQDFMVQFYWECNKVGSEILRALATGLDLEDESYLTKKHSGHNNQLRLLHYLPVPAEELEKERTARCPAHTDWSSITMLFQDDCGGLEVEDISRPGTFVPATPLKHAIIMNIGDLLQMWSNDRLRSTNHRVRLPQLSDRFEGPNRMTRERYSIPYFMSPDPDVTIECIPSCMSEAYPAKYKPTTQAEYNKMRASMMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCL1</accession>
    <name>A0A8G1RCL1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lactonohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_466255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518727.1">
        <property type="nucleotide sequence ID" value="XM_025662120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCL1"/>
    <dbReference type="GeneID" id="37165522"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034748515" evidence="1">
        <location>
            <begin position="19"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="182"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="307"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="411" mass="44583" checksum="FF006A5B8DFD0E86" modified="2022-01-19" version="1">MKLLLLLLGSFTGSLVQAQTGVTHPISEECGPSVVCVNHYANVLPYHFFRNVSTMDAVTTFGDTTVANGTVLQDVKTADFIVYNKEKGLDILGSNPSYEYVFAVNDAVHEAPVYVASQNKLYLSQLAPPPGYLPQLVVDLNQDPPTLSEYLSDPPVYAPNGGTFHDGKIIWGASGGNRSIGGTEQRISLRTLDPETNKTTSLVNNYFGYYFNTIDDIAVHPKTGDIWFTDPQYSWFNDITDTPPQLPCASYRYNTSSGAVVVVDDSIGQPNGIAFTPDGSIVYISDTAAVSAPIDPKYGHPGSTFNTTHRRTIYAFDVSEDGAHAYNKRAIYLAPGFVPDGLKVAANGYILTGCGRGVDVLDPSGELLLTIQTNYTVQNFAWTGPELKTLWLMGNGGISKVEWNLPGQVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCT1</accession>
    <name>A0A8G1RCT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_495393</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521420.1">
        <property type="nucleotide sequence ID" value="XM_025663912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCT1"/>
    <dbReference type="GeneID" id="37167314"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF252">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="36"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH63498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="434" mass="46274" checksum="80CEF74E3E21BF39" modified="2022-01-19" version="1">METKESGRCSPRQDQRYSAAVASAGAPPNGGVAGWSAVFASFLLFATTYGYSSAYGAFQSYYESDLLRSSSASRIAWIGTIQGFFMISTGVFAGPLFDQGYLHSLMTVGCFLNAIGFMMLSLSTEYYQVFLSQGVCSGIGCGLIYVPALSLASTLFTTRRSIAVGLLSSGASIGGTVFSILFIRLQPRIGFPWTARTLAFIQVACSCIAVPMLIATTNPKPSPPRQLIHWHALKELSFDAYAIVIFLFFVSYFVPLFLLPSFAQSALHISIDLSVYMTAIFNASSSVSRIGCPLLVSRFGPSKVLYTSMAISVVILFGWTGVHNVAGCIVFCVFLGGFTGSVVTVIPVLMAHPVISPTPSVFGTRMGVQWFAVSLGVLIGAPIGGALEGYGGSNGFLGMQLFSALVMALATAVLLVPMKAIWRYDHAQRESGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD29</accession>
    <name>A0A8G1RD29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA mismatch repair protein MSH5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MutS protein homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_390767</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518982.1">
        <property type="nucleotide sequence ID" value="XM_025656784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD29"/>
    <dbReference type="GeneID" id="37160186"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03281">
        <property type="entry name" value="ABC_MSH5_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001067">
        <property type="entry name" value="DNA mismatch repair protein MSH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000050">
        <property type="entry name" value="DNA mismatch repair protein Msh5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="13">
        <location>
            <begin position="758"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH61060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="935" mass="104796" checksum="542E9B5F924FDB3F" modified="2022-01-19" version="1">MEPRTKRKRTIHPRYFDSFNPSSKHDDFPRPMTSGNMPPSSQETLRARAPTSNNAEQFRSGSAKFEYSIDDELEQIVVAVDMRDSGTVGCSYYSALEEKLYLLGDLRHSSKDIIDSLVLQTKPTVLLISPRVDPINLQERPWDEQISDTHSYVPYQLDVRPSQEFNYSNAKNKLIALEISSRHEHRIKFFVPHSGLVDGEQLDTENLDLTLQEGKLLHVSSSIDMENTVTIGCAGAILAYLQRRRASMSMFNERASGIFRVSSVEMFTLSGTMFANGRTLLSLQIMESKTHPSMVNQGPGRKSTSSKEGLSIYGLFQRFASTPQGRNRLKQMFLRPSVELDVINERHFFISVYHRADNFNPLEKMVKGLKHIKNLQYAMINLRKGISTGSGKIMGFKATVWATLLAFAFYGIDIHDALRETSVGANLALHNKALRAFEAAQLYKVGRMIQEIVDIDSSEEQGRTVVKPGIDRELDRIKDRYDGMNSLLKQVAIEIATTIPESYDIDVNVIYFPQLGFNIAILLNEAGDAAYRGVEDEWELMFFTENRAYFKDFRMREMDEKLGDIYGIICEKEIEIVYDLAQRVLQYETVLLEASDVCGQIDSLLAMAQAASFYRLVRPKMVEGDVIKIRGGRHILQELTVSSYVPNDTFLVGRRTRGEPLGPFHLTPNPHESDYGPSMLLLTGPNYSGKSVYMKQVALVVYLAQVGSFVPAESAELGIVDKILVKSNTQDSVSQIQSTFMNDLQQLSFDLKQVTGRSLLLIDEFGKGTNENDGIGLACGVLEHLLNREDAPKVIAATHFHEILANGYLKPRPQLQLGHMEVRVHEEPGEAENQITYLYNFRLGRSDQSFGTICAAMNGISQTIVDRADEIASLSARGENLIAACAVLSAQETQALEDADKLAREFLSLNLSAPCDVELMRDRLEKLFDGSGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDL2</accession>
    <name>A0A8G1RDL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_410770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521039.1">
        <property type="nucleotide sequence ID" value="XM_025657493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDL2"/>
    <dbReference type="GeneID" id="37160895"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="424" mass="47851" checksum="AF0B56DE51D6D7C9" modified="2022-01-19" version="1">MEPSPFNITEHVVDCQHIREYARATRETNDVLRIAVKQYTPKSNPDPQPGDVTIIGATSVGSPKELKEPLWEEVYQRLSRQGLRIRSIWIADSAPQAKSAAINAENLGFEPSWFDHSRDLLYMINKFKGDMPKPIIGVGHSIGVGQLLGLTLMHPRLFTSLILIEPVIAKDFASGRGPAFGKSAMIKKDTWKSRAEAEAYFRKALKGWDPRCLDLWLKYGLRDNTAETENPESAVCLATTKDQEVAQSLRPNFVDLQPGSNQSDYLHDPTFWTDVTGHSETLPFYRYEPIVLWRLLKYVRPSVLWIYGGKSIMAGPEQRAEKIQRTGTGVGGSGGHKNGRVKEIVIPNGGHFVPFEDVAGVAGPAAEWIKQETDRWHEEEERIKKGWLELTAKQRSSIPNEWLAQMDKYFMKGKTREAQVRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1REW3</accession>
    <name>A0A8G1REW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_363640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519957.1">
        <property type="nucleotide sequence ID" value="XM_025655664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1REW3"/>
    <dbReference type="GeneID" id="37159066"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045142">
        <property type="entry name" value="BCAS3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268:SF0">
        <property type="entry name" value="BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268">
        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1094" mass="116660" checksum="83B68E6AADF3E3AE" modified="2022-01-19" version="1">MPPAASDDLFRQQSRSLGDTNPFPEDPSRATLEHDLGGKTKKKGKTGTKGKNKAAKAVPKSTPDDLLEVEAPSPSPPLQAEPSSCPNPTLEPPPSNNIVSPVLDALGTLGDSPENDIAYRTGTWAKSIPYGKSPPNDAVDGEFNSGSPFGFLTSQDKGGFSHPSSTSPPPGARPLSYGRGYATSSVSRQHSVDRQKSNSVSSPFNNQVPLPHLPQAHFYGAPDIDLPLFSGQNRAATDGSYSFCAFDTIISPSSKASRMGSSVLLVGTDGGLDVLAIEDRKTRPVGKLAGLNGRVIEAKLLSNTSTHDQPHVAVIIHGPTAQPDDEGHASSNSSEANDIPTGRQSAAGGRPKEETRYYQTRVEVYSLRTGEHITTLLSTPPTPCFGNIPGLPALAPSPAGNLKLLVSGSYVVVASGSSGEVYMYSMSKYQFLGKAWTSIKSKESRRYSTSSSSTDPDGSQSDSPHGSLNSDSPIVALKGRWLAIVPPSATYRATLRAVVPTSLLQGKAFGLETRSPPSRPAITCATDVGEGESFFGKVARGVTQELMRGARWMGDQGLQAWNNYWNKEQAQSMPARRSPNLTEFSPQGYNLFPPTHAQDTQSVSTTEPDLVSIFDLRKLDEGEAKSSLFNPVATFQVPNGCSFLSFSPNGLMLFTASKKGDVQYVWDVMQAKYCRAGAFLSDDPASVQPSVRQVARYPRLTTSHIVDVVWCPPSGDKLAVITGKPTVHVFDLPRSAFQWPPFRRSLPKPAKPPTADAPAEELPDRGPAANPLSAAFKMVGGKTQPILAAVRGRTPSTGAAFPSVGGFAMPSAAGVRGGKAVAAGLSKSMGAAATGTVKTVNTIRHGGEHRLHLSNLSRDPVAARVTWIIHKGMPFLGLIDGGYFRLYRIKRSTSPSKSRQVQSVIGNKELEFRLPPHMQTPCGPMTVGPTATTEPTVSATLALPSAALRPPPASKLKCQPLSQAEIETNTPYQPFHTDQRVNLFVYNEADDSVGSVPTGQWAFGGSLATTKLHVRPFSASSEEDDDMVHEQHHGFGAEMENLISLGNSTGNVEEVVITTRRKKKQASAMAPGGGVDDGFFEDDCEVLDFARDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RHL5</accession>
    <name>A0A8G1RHL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Translation elongation factor eEF-1 subunit gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_433986</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521397.1">
        <property type="nucleotide sequence ID" value="XM_025658445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RHL5"/>
    <dbReference type="GeneID" id="37161847"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="91"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="6">
        <location>
            <begin position="248"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH63475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="409" mass="46187" checksum="D960CE4F1ED13B03" modified="2022-01-19" version="1">MAFGKLYGSPENGRTIACLVAAKANDVEVELVKTEANSTASFNQSAEYTKLSPLGKIPAFEGANGYTLSEVVAIAVYLTSQNEKTTLLGKTKQDYASILRWLSFANTELVPRFGAWCRPLLGLDPYNKKNVEDAAKAAVKNAGVLNTHLTANTFLVGERISLADYFTAALLTRAFATVLDKKYRDENVAITRWYKTIVNQPAFKAIVENPVFVEECIKYTPPKKEEKPKKEAAPAAAAEPKPAEEKKPKHPLEALGRSEFVLDEWKRQYSNEDTRPVALPWFWQNYKPEEYSLWSVNYKYNNELKLTFMANNLIGGFHARLEASRKYLFGAQAVYGANYDCVIQGVFLVRGQDFKPAFEVGPDWESYEFRKLDHTNAEDRKLIEDQWAWDTPVVVEGKEYPFADGHVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGT2</accession>
    <name>A0A8G1VGT2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_407728</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510533.1">
        <property type="nucleotide sequence ID" value="XM_025657374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGT2"/>
    <dbReference type="GeneID" id="37160776"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000003">
        <property type="entry name" value="C6 transcription factor (Leu3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="625"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH52611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="730" mass="81481" checksum="31BDDE73D59A9711" modified="2022-01-19" version="1">MGGASHPSVSPAVGSDAAGPARKRTTAMAGLDSSPGSIDDIDGQDNQEEKKRQPVKRACNECRQQKLRCDVIQDPWTDCSRCRRLKLDCKIESNFKRVGKRSRNAEMEREIIELRKQIATVQAGAIPPSQSASLPPVQTPKQETASQVGSGVYHTPSAMSTDQYMGSHEAVASLLDLRSGFDGTNFMRNGNHHFKRIEDVAVVPERVTELFHLFFTFYHPFLPFLDRDQSPDDYYSASPLLFWTIISVGARRFQADTHLLNSLSGPVSRLVWSTLADIPQSYHVVKALCLLCTWPFPTSSTSTDPTFMLCGMMIQVAMQLGLHRPSHTQDFSKFRVELIEEELRDKVRTWAVCNIVAQRVATGYGQPPSSVYDWTLSSNDSMDPNFRLPDDIRSRLEIEKFCDKVTKSLYTNRRDPVGLCSDQERSTLISFLSRDFDELENQLKAHNDSITNLYLRASNLHLHLSAFFDDTTAKDYRERLLSLYVATTTFLEAAMNLETEVGPVLSYTPYYVYQMMVAGGCTLLKLCKSFFAAHIDMDYAKNLFNRTIWAIRRVSVSSNDLPERLAEVVAQMWRLNNVPTPKLTADGGEVDDSLMLKVRCRMSMSLLFDSVWRWREDARTKGRNLEAYLKNPTNPDSNAESSNSSSIQPTRTSTATPGVAGAADPSLAPAPMLPQANMGVSAPSAVGALPSGFMEPNYEVFDPLNWLLDGLVDLPYSYSTISGIESQGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHE5</accession>
    <name>A0A8G1VHE5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromatin assembly factor 1 subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_197767</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510457.1">
        <property type="nucleotide sequence ID" value="XM_025654497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHE5"/>
    <dbReference type="GeneID" id="37157899"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000461">
        <property type="entry name" value="Chromatin assembly factor 1 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="10"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="118"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="160"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="313"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="217"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="409"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="557"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="644"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="676"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH52535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="720" mass="76342" checksum="4298A846CCBC3C36" modified="2022-01-19" version="1">MKATPLLISWHNDNAPIYSVHFDPNGKGRLATAGNDNNVRLWKVETTGEERKVTYLSTLIKHTQAVNVVRFSPKGEMLASAGDDGNVLLWVPSELQTQSGLGEDRSDDKETWRVKHMCRSSGAEIYDLAWSPDGVFIITGSMDNIARIYNAQTGQMVRQIAEHSHYVQGVAWDPLNEFVATQSSDRSVHIYSLKTKDGQFTLTSHGKFLKMDLPAKRISSSSPAPPDPSIRSQPAAPSSAAAAIVSPAPSTPGTPMTSNLPMDPPPVSHSRRSSFGSSPSIRRSASPAPSLPLPAVKPLEVPSPGLLGGLGVKNANIYANETFTSFFRRLTFAPDGSLLFTPAGQYKTSHVSATDPTKTTDEITNTVYIYTRAGFNKPPISHLPGHKKPSVAVKCSPVFYTLRQGPQPAKHITLDTSSTEESFPSLPEPVVSSTGDNASMEPPTSAPNDQAKNSSTPKATDRAVSQSPAPVFTLPYRIVYAVATQDGVMVYDTQQQTPICVVSNLHFATFTDLTWSNDGLTLMMSSSDGFCSTLAFSPGELGQPYVAPASAAQQTGAAVSSANNTPLPTPVTAKPSSAVQANPTQAPPASPARSNSVSSVTTQSGSSRLINNPTPTLGSVPLVTATHSAQPPTLPLTTPPQTPMSAASQSGTSYVSNSVLGKRAGESEKEDDKDQSAAPQAQQQNQQQPKKRRVAPTLISAGTNPSATLRDEPPNADVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHQ3</accession>
    <name>A0A8G1VHQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">XPG I-region protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_381114</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511508.1">
        <property type="nucleotide sequence ID" value="XM_025656405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHQ3"/>
    <dbReference type="GeneID" id="37159807"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09902">
        <property type="entry name" value="H3TH_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09858">
        <property type="entry name" value="PIN_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037314">
        <property type="entry name" value="MKT1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF32">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Post-transcriptional regulator MKT1 N-terminal" evidence="4">
        <location>
            <begin position="311"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 C-terminal" evidence="3">
        <location>
            <begin position="438"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="676" mass="76005" checksum="9D9CE3A66945FA70" modified="2022-01-19" version="1" fragment="single">VRPLDEWAATRTQSLPLSALKGAVVGIDASHYISQHLLQPSTREPLLVALGGFPFALKSNIERELKAYKDLGVACIFVFNGLDFGKKDQRPHVQQESVRAFEQAWDLYDQQQADQVVDAFSSAGTPRPESLYRFLQRILLQHGVDYIVAPYSAAAQLSYLAKGPNPLIDAICGPSEVLMFDVEKLITRIEIDPAQFFWINKQTCLEELGRLSNDQFLDFCLLLGSSFLQPFPGFETHVFPGKNPTVRDALPMFNAAGRSALALCAQFEEDRRMQELEYTDRYKRACMTVKHHVYIDVDGRVGPMDQENASSDMHAVIGLRLPEELYFYLSKGILGPDVPNYLTSGEVLISLPLGVEDTEIYRQVAGSTLTPIRTQSICLLSNSLHRFYQTKVINSSCGRFQFAVQSLKDSDFVAKSKATKDTKQLSSQDELLANVFWRFLQLRGYIDEKHQLTQWGVCLEQALSGLDPSDALEEPTFLAIEMIRFGLLNSKQWFSHVSGGPMRGSDEDKSLNMLVSRLACIAKLQHKSIGYSGPLSRQLLCYRSLISEVRSTLRTLIEVVLASLLLSGDADRERNDWGELSIKLPFIDDNDCGLGIAVRTYLDDLPLQADPTSPEARAEVKSKGKEWFQHSDSFTGNLDMAFKLWDAVYRGTQSAGKELKEGKQWEDANRWLAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHY9</accession>
    <name>A0A8G1VHY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_452741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511821.1">
        <property type="nucleotide sequence ID" value="XM_025660899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHY9"/>
    <dbReference type="GeneID" id="37164301"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="509" mass="54990" checksum="6373117DABAE7DE5" modified="2022-01-19" version="1" fragment="single">MQQDQRLETLARAFEALLLTTQQLSCREKSLQQRLKYACYQYLKLAGKLPGGVDGHTKVVADKMLGRYAEYDHNPKPNIKPPDVVKALAESGNVGDLALTAITEGLTCYQSIIPPHESRQLSEFDSCLVATRAGVPAPLEKDFTTKGTQGSLRCPFAKHNNKTSENGVSNGTHSPLKDQNGDACGHADLDPIKAEQSDRRSSRAPSTRSSATRCPVSRCPIRYLDQHSPEEIADYVERHKHEIPRSHAICVQRYQRDGQTMRQLDAKYGSLINMIQGLSAKHKAFLPEPSQNGTAPSSSSAERVEKWAQEVDMKSDMHPPIKEEQEEEAAAEQEDEERKGHFDRPLREVRVGESPSRPWGIPVPVSPLPPTASPPQSPPPAPVATSIDAVTSKLPNAAPAGLSSMPPPGNTAPAPPANAPTKGRCPFGHGAPSGDKPSAKMETIPTPVKVDKADEPAEKKNGELPGDSPSPSNKPAANIVFNGPVFFGFSAEQTAAFMQQLTNLGAKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIC4</accession>
    <name>A0A8G1VIC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_471844</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511447.1">
        <property type="nucleotide sequence ID" value="XM_025662511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIC4"/>
    <dbReference type="GeneID" id="37165913"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF40">
        <property type="entry name" value="THIAMINE PATHWAY TRANSPORTER THI73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="50"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH53525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="496" mass="54489" checksum="9BEBCCE5A68323BF" modified="2022-01-19" version="1">MEEKLPDAFSQALPVDRTDDAVEYLQGHAAGPDSSQIDLRALRRKIDWHLIPFMFCCYVLQFLDKVMLNYAAVMGMKTELHLAGNEYTNTATWFFLAYLIAEAPNIYCLQKVPAAKWLGANVALWGVAAAASAGAKNYATLLTARVFLGIFEATIGPSLMLISSQYYTKSEQAPRFTLWYNGLGVAQIIGGLVSFGFQHVHHGATLAGWRIMFLVIGLATVLIGVLTLLLIPDTPMKAKWLSEEEKVALLQHVSVNQTGVWSSTINLKQIWEAVLDIQLWLLVLITILISVSSGVVTTYSATLISGFGYSGPISALLNMPSGIVSIFFTLLVGFGIRRTSHRWAWNAFCTIPGIIGGGLLSFLPKSNKAGVLIGIYLVNAIVATLPILYQWTMANCAGHTKRAFSSALIAGSFSVGNIIGPQTFQARDAPEYRPAKIAVLATQAAAAVMSVVLFAYYVWENRRRDSRYGKVEDSMVDEAKWAGLTDKENTRFRYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIM5</accession>
    <name>A0A8G1VIM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UBC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_157442</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511329.1">
        <property type="nucleotide sequence ID" value="XM_025654204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIM5"/>
    <dbReference type="GeneID" id="37157606"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000093">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcF), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="195"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="293" mass="31881" checksum="76689E9ECCAA263B" modified="2022-01-19" version="1">MSPSTRRLLKESTDLQTNPSPYFHAAPVSDTNLFDWHFTLLGPPAPSPYAGGIYHGRITLPPTYPLRPPSFRFLTPSGRFEVNREICLSISGHHEETWQPAWGIRTALIALRSFMDGDAKGQVGGLDVADEVRRRYARESRAWRCDGCEGSKGRGNEVVMREWWGVCRERGGVVEGEEDFEGEEDKSEGKDGDEAAAADAGISAGVDAGADSTSQIAQAEVQPQQPQQQQQLQQHTPPATRPLPPVPAAAPAAAAAAAATSQDTPWLDRAIIGVIIALVAMILRRLTRDMDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIR3</accession>
    <name>A0A8G1VIR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_146566</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511837.1">
        <property type="nucleotide sequence ID" value="XM_025654110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIR3"/>
    <dbReference type="GeneID" id="37157512"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000015">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000377">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="248"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="341"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="365"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="405"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH53915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="464" mass="53473" checksum="5F09744A68A5589D" modified="2022-01-19" version="1">MSVLLETSLGDIVIDLLVDDSPKACENFLKLCKVKYYNFSPVHSVQKNFTFQTGDPIGPDSSESDGGSSIWGLLQGPSQRTFPLQLPSKLKHDERGTVSMATVPSPNDPDLRIAASQFIITLGDNLDYLDGKAVIFGKVVEGFDVLEKVNEAFIDDRGRPLKDIRIRHTVILDDPFEDPEGLVEPPESPVPSKAQLATVRIADDEDLDDDMDEESMERLRREREARAQALTLEMVGDLPFAEVKPPENVLFVCKLNPVTQDEDLNLIFSRFGPILSCEVIRDKRTGDSLQYAFIEFENQKDCEQAYFKMQGVLIDDHRIHVDFSQSVSKLSESWRNATITKRSGQRGGFGGVAGLEKKRQYRATENTRQRDDDYHMVFDKNAPKARSNRDERSYSRSPPRKPQRERRVSRSPRRDSYRNRYRDRSYSRSPPRRDSCGDRDRRHNDGERRRDHRDDDRYRERRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ22</accession>
    <name>A0A8G1VJ22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_401976</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513066.1">
        <property type="nucleotide sequence ID" value="XM_025657175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ22"/>
    <dbReference type="GeneID" id="37160577"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15735">
        <property type="entry name" value="FYVE_spVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21385">
        <property type="entry name" value="GAT_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000031">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000161">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049425">
        <property type="entry name" value="Vps27_GAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21356">
        <property type="entry name" value="Vps27_GAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036956">
        <property type="entry name" value="Hrs_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="15">
        <location>
            <begin position="24"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="14">
        <location>
            <begin position="165"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="491"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="581"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="614"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH55144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="704" mass="76619" checksum="9375C1A6C8FAB366" modified="2022-01-19" version="1" fragment="single">MAGWFSSTSPIEDQVEKATASSLEDIALNLEISDLIRSKGVQPKDAMRCLKRRLENKNPNIQLATLKLTDTCVKNGGTHFLAEIASREFMDNLVSLLKTEGAPLNSDVKAKMLELIQDWAMAAQGRMDLSYVGETYRRLQDEGFRFPPKTQISGSMLESSAPPEWIDSDVCMRCRTPFSFMNRKHHCRNCGSVFDAQCSSKTLPLPHLGILQPVRVDDGCYAKLTSKALAPSGLSDRASFKNNSITKSSVMEPRGGRAEGGFDDDLRRALQMSLEEAQNKGSSGYVPQSTVQQPPRAPAQPAVEEEEDADLKAAIEASLRDMEEHKQKHAAALKNTSSADTQSRQTPSATPLPKNSYELSPVEVENIHLFAALVDRLQHQPPGTILREPQIQELYESIGALRPKLARSYGETMSKHDTDTLLDLHAKLSTVVRYYDRMLEERLSSAYAHHSLGYSPVPGGSPYPNIYPPMPAQAPDGKTGTESFYYGNPIAESHQAPTAPYPQPQPERELHERVGTRSGTMSPSVYAHPSQPISPSVPWNGSAHAVASPQPSSASMAYPSNPSAYAGPAGPTQFYTSPPHVESDVKPAQHARPMEPDMPYQGSPVMQRETLYQPSAPSAPDLPADQGPASGYGLQRQPTDPSAALFYAPQPPQGHPYPAYPQGAPVHPGQAGGDVSPVGVTPAHAPYQQPTPSRPPVEESLIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJU2</accession>
    <name>A0A8G1VJU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_499769</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512544.1">
        <property type="nucleotide sequence ID" value="XM_025664082.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37167484"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF28">
        <property type="entry name" value="SYNTHASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="26"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="910"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2399"/>
            <end position="2476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="910"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1052"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="942"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH54622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2483" mass="270424" checksum="29A55BFF1F820034" modified="2022-01-19" version="1">MPSRENGLSGSAPHPGGQANDASTTFSPIAICGMALRLPGGLGSPQDLWDFLIAKGDARSRVPESRYNVSAFHSPSKRPGTVVTEYGYFLDESIKLGALDASRFSLSRAELEAADPQQRQMLEVVRECFDDAGEVNFRAQPIGCYMGCYGEDWLELQNKDPQQNGMNRVDGYSDFMLSNRVSYEMDLRGPSITIRTACSSALVGLNEACLALQRGDCDAAVVGGSSLIFAPAATAFMTEKGVLSPDGSCKTFSADANGYARGEAITAVFVKPLAAALRDGNPIRAVIRSVMSNSDGKTPGIAHPSTDSQEALIRKAYRAAGITNMAETAFVECHGTGTPTGDPVETLAVARVFGDAGVYIGSVKPNLGHSEGASGLTSLIKGVLALENRIIPPNIKFTAPNPKIPFEACKLTVPLDPTPWPESRWERVSINSFGVGGSNAHLILDSARSFQIPSPTPDDFLAGPQLLLLSASVAGSLQRMTETFENWVPQHQDQLCNLAYTLATRREHLPHRSFLIGGPDRIVTPSPGRKVPTSAPSLAMVFTGQGAQWARMGRDLLLRSDFSFQNTIRALDKYLKAAPNGPKWRLEEELLKPALTSRVQTAELSQPLCTAVQIGLVDLFAAVGVTPAAVVGHSSGEIGAAYAAGALTAREAIIAAWQRGLAAAGQARPGAMAAIGLGWEEVQSFLSPPAVVVACENSPKSVTLSGDAQEVQAAVARIKKEHPTVTARLLKVDKAYHSYHMREVGTKYSTTIGRDLVGRRPGKPFFSSVTGKQEQDLPLDAAYWQRNLESPVLFRAAVSELLDHVDNVAFLEIGPHAALAGPVRQILTARASSNSVPYLAAMSRGEDCVESFLTALGKLFQLNFPISLNALYPSGSCLPGLPRYPWDHGVDYWRESRISRDWRFRQFASHPLLGDRQLLGTDLEPSWRNMMRVEDSGWLRDHKVEVDIILPCAGYLSMVGEAIRQISGSHGSYTLRGVVISSALVLREGTPTEVVTTFHPHRLTDSLDSQWWEFTIASYNGQTWTKHCTGQASGMAAEEEQTRTAALRDALPRKLQSKKYYDLMDRAGLNFGPMFKRLINIETGTGERLARAKVTTNQAGDETYYHLHPTIIDACIQAAPLAGLLGTVDAKAYRRVPTKIDRVIVRQAPTRVDDLEVSASATCVKGTGEVIGQVQQCIADGTIVMHMGGLKLSPLEEAGEAGKTDGLETTARLTWGPHIDFLDATTLIKPSFPRHLYTPALDELARLGMIYGSRRIKDASTPVAHMPLYRDWMNRQVEAMRLEEKWSTFLALEDEALVERIERLVQHLSETPVVDCAIGLQKVATNIAALFTGETEALDILLADDTLYKLYVVTDACDRSQFIQHLAHTKPNLRILEIGAGTGATTASILKLLRLPSSTGSSSTPSLFSKYTYTDISSGFFVTAKERFSGESNIEYRTLDISKDPSEQGFDGEKYDLILATNVLHATNYLGETLRNVHKLLDPNGRLLLHELNSPSKWPNFIFGTLAGWWYGGPDGRPDEPCVSPARWELELKGAGFAGLDAVVLDGEQPHQLNAIMVAKPQVDDGTDQKRTVSLLCDPSDDSYADSLSRRLNNRGYEVQTFRLGDELPQSQDIISLLDCTRPFFEDIDAARFAAFQHLLNTVGESGLLWITHLSQVQCPDPRFAQVIGAARSIRSEMLVDFATCEVDDILSSLDKIIEIYAKFHTRSKDELLNPDYEYTIVGGTVSVGRIFPFSLKDDLAVVTEPDDWVTLDMEKPSRLSSLHWKASKGRPLAGDEVEVEIYAAGLNFKDVLGALAVVPFPDNGLGVEASGIVRHVGPDVKRLCPGDRVMLREDGTFATHAIASEKLCAKIPSDLSFEDAATMPVVFATALYSMFDLGGLQEGQSILIHSACGGVGIAAIQLARMAGATIYATVGSEEKVQYLIETYGLPRNRIFNSHDSSFVEGVMRETQGQGVDLALNSLSGELLHATWLCLAEFGKMVDIGKRDMLGAARLDMGRFLGSRTYSCFYLDLLRDKRPSECKRLLELIMTYFRAGHITPIRPITTFDASAIEDAFRHMQQGTHLGKLVILLRNADGSPKIDPTLVKASTSLDLDSTASYLMIGGLGGLGRAVSRRLVEHKARRLVFLSRSAGQGPNDNDFVRELESMGCDVRLVQGSVTNEADVKRAIQQAPNLKGVLQLSMVLRDQAFPHMTLAEWNTAVAPKIQGTWHLHNATQAAGITLDFFVLFSSTSGVLGLPGQANYAGANTFLDAFVQYRTRLGLAASAVDIGAVQDIGYVAEDDALLQRLKQTGAHHLTESELLEAVLATMSSSVNPNAANNVNNGLVFVDKNNFILGLRTSVPLSSPESRVFWRKDRRMALYHNSVAKTNVHDVSSDGDTLQAFLARTKSDPYILRSGESASLLAREIGNKLFNFLLKTGEDLNTSLPLSQLGMDSLVGVEMRSWWRQAFGFDITVLEMMGMGNLEGLGKHAAEGLAKLLGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKE6</accession>
    <name>A0A8G1VKE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_451389</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513532.1">
        <property type="nucleotide sequence ID" value="XM_025660581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKE6"/>
    <dbReference type="GeneID" id="37163983"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034972892" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1" evidence="10">
        <location>
            <begin position="25"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH55610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="504" mass="56281" checksum="987283D2CF2E3CD3" modified="2022-01-19" version="1">MRPFTALAALCGLFLSSSNSLVYADSTPSSSPVALPRDFKPPQVFKNTNLVRNTNLEKGYLRETVNVVVENVDKKPQSDYYLSFPSDLYDKVGALEVRDKSAPEQGRFEVEATEFDSNRDFQYFVVHLPKPLAPSSQITLGISYSALNTLKPRPAAISQTDRQYLAHAFSAYAPSAYTTATQKTKIKFPSTNVPDYTTTDLTSGADPERQGATYTYGPYADVAPETTYPASVRYEFTKPVITATLLERDLEVSHWGGNLATEERYWLRNNGSKLTDNFNRVEWTISSYQQLPSSAIRELKIPLKPGSVDPYFTDDIGNVSTSRYRPGKVPNRDASLELRPRFPIFGGWNYSFRIGWNNDLSAFLRKAVTGADSYVLKVPFIEGPKVPEGIQYEKAVVRIILPEGARNVRYELLEKATSNGLPGANQIQTELTSHKTFMDTLGRTALTLTVEELTDEARDSQIVITYDYSLWDGLRKPVTITAGLFTVFVAAWAIGNIDVSIKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKU6</accession>
    <name>A0A8G1VKU6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Brix-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_44471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514823.1">
        <property type="nucleotide sequence ID" value="XM_025659090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKU6"/>
    <dbReference type="GeneID" id="37162492"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000005">
        <property type="entry name" value="Similar to RNA processing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="227"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="454" mass="51842" checksum="4EFD1356BCE942A9" modified="2022-01-19" version="1">MVSKKASHRPPPGVGLDAKPRNKIQRKLLHIKRKRAKDSSRRAERYAFKKEEAKNPKLKEERLKRNIPLTIDRKRVWDDAGSDVEDGLGLSVDVERIKRRKQEEEEELNRPLNEDDQSSDAEEEEGSEDDEDDDVDSMLASSDEEDEGASDDDDDDDDEDEDSSSGKKKSKSSSDSTRGRSKSSLPTATERATSPSQSTKSTNLNLVPEALASKFPSLFSTENPKSPKILITTSLNSSLHHEAELLTDLFPNSVYVRRTRHRFAHQFSIREISKFATNRNFTAVVILREDQKKPAGLDIVHLPTGPMFHFSMTNWVEGKRIPGHGRATDHWPELILNNFRTPLGLLTAHLFRTLFPPQPDIEGRQVVTVLNSRDYLFFRRHRYVFREKRETEKAVVGADGKEMKGAEGIRAGMQELGPRFTLKLRRVDKGIQRASGQEWEWKGQMEKTRTKFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLE5</accession>
    <name>A0A8G1VLE5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_450364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="RAH56332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025660357.1"/>
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    <dbReference type="Proteomes" id="UP000249526">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
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        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="32"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="300" mass="32945" checksum="862172F0799FFE1B" modified="2022-01-19" version="1">MAATTTITVPHLGGIDVGYRLSNNNTYDPAKPTVVLINSMCMTVALYEPQFNDETLTNAANLLAIEPLGHGATHCHVAEHFTYWDTAIMALQVMDKLGIEKAFTLGTSQGGWIVMRMALLAPKRILGVLPLGTSMDYESSDSRTKGCWDPVTLLTPFLEKWSSATPTPDFVVDDVWCGMVGGIGFGKGATEETVGFWKDVLKEVYKGDEGRKKVRMALMCLLTRDALVLRLGDVQCPVYWLQGTEDTPFQTTVASEQISKFTRSKEAKLVQVQEGAHYLNATNPREVNAAVLEMVQKYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLY4</accession>
    <name>A0A8G1VLY4_9EURO</name>
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        <recommendedName>
            <fullName evidence="5">UBA domain-containing protein Ucp14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_449952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025660274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLY4"/>
    <dbReference type="GeneID" id="37163676"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
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        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="30917" checksum="B65719914FB636FF" modified="2022-01-19" version="1">MLTSGLTNASISKSLLIYTIASSVALAIFDLKHLTNIQVAPHIWQYGQFWRILVWQVAGFANSTEALFAAMLVYHLRVVERAWGKRKFATFLLTTLPYTTLLPPLLLILVLRPITLGKMNYLPSGPVATIFALLAQYHASIPSTFRYRISTSSASDSNETKDQPQQSSKSLTLTLSDKSTTYIVAAQLALSQFPAMVVPAAVGWLVGVAWRMEFLPGTGAWRVPAWMVGEKERRVVNGAGGADGGRYEDLRRRLEGEAIAASASSSATGATGDAAGQRLRRSGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMA1</accession>
    <name>A0A8G1VMA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_477275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516561.1">
        <property type="nucleotide sequence ID" value="XM_025662830.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="37166232"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="226" mass="23821" checksum="1060774FBA22E644" modified="2022-01-19" version="1">MSNTTTTTTATTNTNNNPHNIPPYTPMTSLSHELGILFGFLAACFIVMGVYVFFWRAAEFREERAQTLRRQMLLTRGIHHGRGGIGEKFITHHHGHVHDGRCLDGSAGAAAAAAGLHQRNNNNYITPENSASAGSGGTLYKQENENEIGVALTTGMDVGVGIVASPSLGPMTPTSVSASGAGREIPVGGLSRMNVNQGAAAAAGVGRDEVEYGVEMDVLGFLQRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMV0</accession>
    <name>A0A8G1VMV0_9EURO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_448045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517013.1">
        <property type="nucleotide sequence ID" value="XM_025659850.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="37163252"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="370"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="406" mass="44863" checksum="F370B26C002F1168" modified="2022-01-19" version="1">MNRSPRVATRCLRQQRLRQSAGRYRNARFQSSSSSSSSSSGSTGTGSSNPALVGGLSGGLVAIVTGYTWYHFSGARKAVKTMKQTQVYADQVKQGIINNAPEPDKALNWLRDTLKSYAVFLPGVSQHIDTAFDDLEKVKQRHGPEVDSIVRDAYKELKSLGNKGGSNADTAIQALQVLQKSLTRLMELSGDAAGDILDNHPWLQEKVGGGWKQLKEMGEAYGPQAKEEVDKTREQLAGVAKKGFSLASVEEVRKLIQEKSEKLQKLGDEMWQKGLEESKQYLDKNPKVKELVENNADALKKGNVSELWGMVKEAASSGKTEQVEKYVKEKVDQAQQSGSFDLSKWADMVPGGSNVLGQLQSLRTLQEKKGKEAENVLKETMDEIQQVLKKRKEQMEKLASEAKKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMX4</accession>
    <name>A0A8G1VMX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chitin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_418361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517088.1">
        <property type="nucleotide sequence ID" value="XM_025657812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMX4"/>
    <dbReference type="GeneID" id="37161214"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17742">
        <property type="entry name" value="BRCT_CHS5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13945">
        <property type="entry name" value="Chs5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000088">
        <property type="entry name" value="Chitin biosynthesis protein (Chs5), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000453">
        <property type="entry name" value="Chitin biosynthesis protein CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="75"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="163"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH59166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="418" mass="45256" checksum="EB29AE6D23071D2D" modified="2022-01-19" version="1">MLVSLTVGKVDAGVAVLLTQDNRLIEFPSVLLPSNITSGSIVDITVARNHAAESASAANFQSLQKRILNTYGIKTPTPPVLRLRNATQTSLVLEWDPIDLATASLKSLSLYRNGSKAGSIPRPLETRSTKISGLAIHTEYTFHLVLRTTAGTYQSEKLTCRTHKMTDLSGITVTAGVLPPQQKDALAAALDRIGGKLIDSVRIDTTHFVCTEGRGPLWEKAVEMNIPVVVPEWVDACEAEGTIVSVRGYYLNADPKARQLGPIHSSTQHQRTVSTATSNLAPPAAQAQTPSRQTGQEDEQNLEPPVTPFPGAEMTGQPIAEEKEVGSDESTESPPPPPPKDEEKEDETAEQNGDHEASPPPPEKDESESEGEGKDEEEKTEEDTQEPEEEEKEKDDSSNAKERKSKEGGEGDFNEVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN68</accession>
    <name>A0A8G1VN68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_437469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516189.1">
        <property type="nucleotide sequence ID" value="XM_025658621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN68"/>
    <dbReference type="GeneID" id="37162023"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="54455" checksum="32E0759681D62FF0" modified="2022-01-19" version="1">MPPPSQNIPLASTLVARFLRTNNYTQTLKAFLQEAGLPSDAGEQRGKDNTSNWTIENVLEEKKAFDQSKNFERYGDNDKDKDVWSVPAPSKPNIIQTPTSSNLLACSVEQWQRPDAQAEPYLIATGADKHLHLFQTSPGHDLVQSFTGTSEAPILSYIPIQDGKYVLMTNMSGQILLQKGAEIIDRRKDHAKYAVKVIAYEQKEDNDNNNDDGADTTSTSTTIWIATAGWDSKIFLYRMQINNEASTQIGDPIASIPLLSNPESILFTTHIDNPQDLILLVSRRDSSNLYYYHVKPSADSTTGYECPLIGKQNLAPHSNAWVAFSPSCLALSPHDPGLIAIATSTLPHMKVMIVRLLFPSAESLETGSAEQEQEPATQAAQAFAALSLQNREDAAILIQANTFAPQTAYSTPQVVWRPDGSGVWVNGDDGVVRGVEVKTGRVVTLLKDGHEVGCKIRTLWAGWVDRGEREEWLYNSLFTIKPYKAPTWYGGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNG0</accession>
    <name>A0A8G1VNG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_513026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516667.1">
        <property type="nucleotide sequence ID" value="XM_025664681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNG0"/>
    <dbReference type="GeneID" id="37168083"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF250">
        <property type="entry name" value="MFS-TYPE TRANSPORTER AFUA_1G00970"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="19"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH58745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="410" mass="43558" checksum="AC25660FCD01CF87" modified="2022-01-19" version="1">MAHPNDAPSTKPPSEYTPIAIMTLLGSFCGMFCTVGFVNSFGLFLEYYKKDQLSNQPESTIAWIASIDIFFIFGVSVVSGPLLDTLGPRLLLCIGSLGTIFSIMMTSLCKQLYQFILAQGILLGISLSLLTCPMIALVGQHIKIKRGAAVGIVIGGSSLGGVLWPIIVNELLKKPNIGFGWTMRIVGFIMLPLLTVTCFCCRPAAPPSPSQQSQVQPEPESEKPTPSPKESESESDTSPLLKNPTLHLTCLSFFIIYFGMFSPFFYVSSYGVAKGFSSSLSFYTISMLNGASLFGRIIGGILADKYGRFNVCIVFTILSGVVCLCWTKATSVAGLVVFAVAYGFASGAILSLQQACALQLATPKTVGLAVGVVMGATALSAMAGIPISGALVQKYGFLALSVYAGICFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNT2</accession>
    <name>A0A8G1VNT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-I complex subunit VPS28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_365889</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518166.1">
        <property type="nucleotide sequence ID" value="XM_025655759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNT2"/>
    <dbReference type="GeneID" id="37159161"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.200:FF:000003">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="8">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="7">
        <location>
            <begin position="149"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH60244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="243" mass="26745" checksum="6C86A42E89CF4C36" modified="2022-01-19" version="1">MYTQRPLAYAPTPYSYTPNPALAASINLDEEVKLASSAAERDLYESLAEIYGIIVTLDGLEKAYIKDVVTEAEYTETCTRLLKQYKSSLGDETVANEFVDLETFKRTWELECPRATERLRIGLPATVEQASHSTPAANMAPAAAGPAGASGSLILTATENFITFLDALKLNMVSKDALHPLLSEVIQSVNKVTDVDFENRGKIIQWLITLNQMRATEELGEDQARELAFDIEQAYLGFKATLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPE1</accession>
    <name>A0A8G1VPE1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_517128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518811.1">
        <property type="nucleotide sequence ID" value="XM_025664885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPE1"/>
    <dbReference type="GeneID" id="37168287"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF51">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="49126" checksum="6B43FDC0C4FF82BA" modified="2022-01-19" version="1">MAFPIRDASGTGTNMPHPAPAKEQFNDLLTISRDALTTLAVEVRRKQTIDTFTTASVIFCHEGSRNVIHVVEFDDQVRYIVRLPISCRPGHCTETAKRALISKVEMMQFIQKRAHFPMPEVYDFDVSSGNVLGTPYIVESFVPGTLVSDAWFDDSGALSLDQKRLRILDSVAETMAKLHRFCFDGIGTLGPDVHGDLRVLPCYHSRKGSGTDVQYAEYSPYESTVDFLRERLLKSPSGAEEEGPFDVGCLIMLEMMIGCMPSSTSQKDETDETFVLAVPQFDSTNIRVDEQCNVSGIIDWDEVQTMPRFLGYATFPKWIMRDMDPVEHGKSLDTQEDSAERLRWYRLLYNRKMQGLLNKVGDARFVNKTHIFASILLAIDNPAARKEIVQALVAKVFPAKLEKATRLIENAGNGELGRQDRERLREGFDLLLSISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPE3</accession>
    <name>A0A8G1VPE3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_359069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518618.1">
        <property type="nucleotide sequence ID" value="XM_025655501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPE3"/>
    <dbReference type="GeneID" id="37158903"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034379352" description="Cell wall protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="45127" checksum="035904C5D5E03511" modified="2022-01-19" version="1" fragment="single">MRSDKLLVLAGLASYALALPTKDLDPRTFGLVAEILTDLGEDLTGFIEALLGGGVKSSASLLTGISAQAAAVLEGGALGCTAGKIDASARAELAAWIRAHASFDASLKSSLLAWCEGEDSATLSVDVRAGLALFIPTCAEVAAKGDIYVTVDGIFSVSDLEAAVVLSSSFQSTLSTFISGSVGVELDADIKAGLSLCAGGGVVADLASDIEAALKVWLNGSACSLSASLKAAVLAWLEGKASVSGVVTIGTVPTAGLTTVSVGAAINALVETSGALTASAQAYLSAFLKSSLATDIEADVKVVLEACISGKLATSISADARAALAVWLSGDSCQLGVELKAVLYFWLSFALSGDVTVDLSTDIITELETFITGTIDTLIGVNISGVLSLLLSGESLASLSLESRAELSAVIGGCAGVDISSSIEIIVIEWLTGCSIPGGPSIGSGSGSGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ90</accession>
    <name>A0A8G1VQ90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase 19.3 kDa subunit mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_483817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519711.1">
        <property type="nucleotide sequence ID" value="XM_025663186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ90"/>
    <dbReference type="GeneID" id="37166588"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="5">
        <location>
            <begin position="107"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH61789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="232" mass="25943" checksum="53E5D31C57C1CD78" modified="2022-01-19" version="1">MLPLTGRAIPGAIPSALHVRPRITSCHFRIQPVSFLSTSSIKSATAIEQRGQSGQALTASGKVRKEVPLPSQEKKEGAMQYVLTTLDQVANWARQSSLWPMTFGLACCAVEMMHLSTPRYDQDRLGIIFRASPRQSDVMIVAGTLTNKMAPALRQVYDQMPDPRWVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTSEALMYGIFQLQKKMRHTRITRMWYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ93</accession>
    <name>A0A8G1VQ93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rad2-like endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_485652</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518439.1">
        <property type="nucleotide sequence ID" value="XM_025663338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ93"/>
    <dbReference type="GeneID" id="37166740"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09906">
        <property type="entry name" value="H3TH_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000037">
        <property type="entry name" value="Rad2-like endonuclease, putative (AFU_orthologue AFUA_3G13260)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000051">
        <property type="entry name" value="Rad2-like endonuclease, putative (AFU_orthologue AFUA_3G13260)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041177">
        <property type="entry name" value="GEN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037316">
        <property type="entry name" value="Yen1_H3TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18380">
        <property type="entry name" value="GEN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="4">
        <location>
            <begin position="111"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="477"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="541"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="724"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="544"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="672"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="803"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="837"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH60517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="874" mass="95585" checksum="F08E65CAA3EA0FD2" modified="2022-01-19" version="1">MGIPGLIHAIGAGERISLSRLAITHLERTARPIRIAVDISIWLFQVQAGRGGRNPELRTLFYRLLKILALPIHPLFVYDGKNKPPFKRGKAVSSRSYGSAPIIRLSKILVDLFKFPRHEAPGEAEAECARLQRAGVVDAVMTNDVDALMFGSTFTVMGFSKESGSSTGAATHVTCYRMNTAGDPSSVKLDRAGMILFAMLSGGDYLPLGVPKCGSKLAGEIAKAGFGADLLEILESDGAELDARLSDWRERLQYELEENESGYFQTKHKVVRIPDTFPDRTILSYYANPVVSSTGEIRALQHNLSNAWDKDIDVVELRRFAADAFEWNYRSGARKVTRLLSEPLLSYRLRLGRQASAFPANCPTLSNSNTPMLQKIYKSRSSYSTDGLTEFQLDMIPVDIVGLDILADEPNPPLPSQESTVSGDEEEELEDNVVSVPQSPVKKRVVKRYDPYASEKVWVFETLATIGLPEVVKNWEREQAEKSAPKKTATRKTGPRKKGPIDPNMKRGSILKYGTLTKERTEISRHKSAQLLEAAVSAKATAVPSLSSSRQSQDSPNPSRKPSASDISIQQQLLTDSSDDSPSLDDLIDQFSSLSHAPSSTTIKQQSPRTTRVRGRAGRQPALTDATGRKTKKLASAESSPALSPTKENAQSSSKRCMRKGDATDHKKSALRSISPNHAGRQNASKPRRKGDKLKSACEVDELQQAISSIALDDAQSRKDAAEPICLDHTGPMPRRSSRQKVYNTRSGPAGAAERIARPSPSVENGEPVLVPEEDNAVDTSKRRDRENPSSRAQTSSSASEPTELKPRKGKSSEKPDDCPSTVSHIESVVVHDGFWTTDTSSKTGSAEAASTTDTRTSRGKKKRIARVSILDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQB3</accession>
    <name>A0A8G1VQB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Mediator of RNA polymerase II transcription subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Mediator complex subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MED5</name>
        <name evidence="11" type="ORF">BO85DRAFT_388946</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQB3"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014801">
        <property type="entry name" value="Mediator_Med5_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08689">
        <property type="entry name" value="Med5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH61864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1035" mass="113321" checksum="874166BC3ECA15E9" modified="2022-01-19" version="1">MTSSEQWGTFLQQCLLHRIDAAEFKNLTRLLMQRYPIGEAQLLDVLLETRLATGIKWDPLPPLYIDCLCKMGLVRTSTMLNSLLKHSSIHDKLPSAGDSETSAAAAAAAQGKQKRKCYTLMTDIRVVQDAMLSVSTGTASKTFAEALSIFASIVDWIQAVVAWHHSHLDTSHQTGGLMSSPDAVSLFESLGILLAALSGTAKGLEVLSADSHEALKIKLGQALSAYLPLCVEVSLPLRNRLDSLQKEFNLFGEPSSKALDVSMMENVNVNALQFEDSVMDGPVINSRAGLYVYINAMLVGRPLVDDSMLLNFLSNRYGGHYQVLIEELITASFDVLSNASYRNESSRTMFLFRSFLVNKLPTFIAAMLAASIVSLPLPMELCISHALSRLDPNTFPSFSQMFAMQSNTVLSDVRQEFLFACASHKLIPESSIERLLGENPMQTLPVGGPYNKDELVSQINANPERAEQLINEIESMEGNAGAIVGAITDVMHHLCNQKETMTLKNICNSLSRRPQALDVILLFRSLKQVLQPLCALLDAWHWDEDQGESQPVYDEFGSILLLVLTFKFRYDLRPQDMGIGGSNSFVLRLLENGFCSQKLDDLSEKQNKNLGSWINALFMAEGISEETMSACSPQEFYMLVTTLFNQSLSACEAGKLDFDTLKGGFEYLLEPFLLPSLILALNWLGNHIWEYESDPSIPLKALHSLISPSSISGEAKEIHRTVLNITARSLEEQLKSIRARQPDDTIKPILEALEPHLSFQRSGSTHRSELESWTAHTPGGLLASIRSTFQSLVLWSTSPDMSMAPQSYTHRQFIAGIHIQGSMRVLCALIDELKLQATTSPTNTTGSSDLALDIAATMICAPLADSFAVDQNTYSPHHHIDPTNTTKEIPPRNPILTPRGALYQLHDSVPKICEKDPLRAEIIVRLWRRVNAALTPPSQLDMNNIIQNMQLGVGVGGPGQMDLETSGAGGHEEESTINQMLDNAVAAGMDGGGGAGGMGGMGSGGLDTSIDDVLNAADMAVGNPEFLDLDMEGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQC2</accession>
    <name>A0A8G1VQC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RAD52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_412641</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519816.1">
        <property type="nucleotide sequence ID" value="XM_025657576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQC2"/>
    <dbReference type="GeneID" id="37160978"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004585">
        <property type="entry name" value="DNA_recomb/repair_Rad52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00607">
        <property type="entry name" value="rad52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00077224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="594" mass="63157" checksum="91414171738D6B5B" modified="2022-01-19" version="1">MPAVGDQHRGNPASIMMPNSTGAITTNPFEEPQRRINEYTAQEIATLQARLDKKLGPEYISSRPGAAGQRVHYLSADKCINLANEVFGFNGWSSSIQNIQIDFVEESPNTGKISLGLSVIVRVTLKDGTYHEDIGYGHIENCKGKAAAFEKAKKEGTTDALKRALRNFGNVLGNCVYDKDYVSKVTKVKTVPAKWDVDELHRHPDFVPRKEPVKPKPSPEDDDLPPRPTDVGKNSSLDDSMTFDGDGEFGSDLFDEADFGVGGSGNPDEVVLGPETQKQPPTPLNGPNVPRQPFNNNARAPMRPNPAMVTPSKPERPFNPAPGARQNPAPQPFNSRLNPSAAQNQPAPQRQSMPPQAPQQNLPNNRMVPPAQAAAAASNTSGAVPIKREFGAPTTNEPPKPQDTLPGTPSASFFSARAVDLLRDNPNGIPSGAPVFDPHAESPSIRKTAGIDHNKSLPVSRPMLAGTGAASPATNNARDFVNPSQDMNRRIGAPGMNSPMSRPMTTSSYRPLTRPNINAPGAAAAANRASTPGLAPQNMNGKRPPLSDVTNASNPSGGSGPAPPVGVENDPKRPKITPGGAAAPAPPQQPQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQE7</accession>
    <name>A0A8G1VQE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="13" type="ORF">BO85DRAFT_516520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQE7"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000245">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="212"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH61969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="513" mass="55511" checksum="26E6BE5D72E88813" modified="2022-01-19" version="1">MRPLSRTALRPYVCPSCQLGRLPARRRYASHSPSNATAPEIYDVVCVGGGPAGLGLLAALRANPTTSKLKVALVETQDLNKARSWSLDAQNYSNRVSSLTPSSVSFLKKIGAWDHLDTSRAQPYQEMQVWDGETGSRISFDWSMETSPFEDLRTVATMTENSNLVRALLSRIAASGDDNLSLFSNSTVSSITNGTDTPDGPDLSAWPVLSITPTNTTTTTQPPTRIAARLLVGADGINSPVRRFADIATDGWDYNRHGIVASLSLADLDPAPFPLGMRTAYQRFLPSLGGPIALLPLPNNNATLVWSTTVENAAYLKSLSPKAFISMVNAAFRLSMTDLQYMLRMERPSSTTTENPYEDELTWRLQHTPQPSHLPPMVTGVQEGSVASFPLRFRHASTYVSPRVALVGDAAHVIHPLAGQGLNLGLGDVASLAQTIEYAVHHGMDVGDLLTLERYAWDRYGTNAKIGGACDVLHKLYNVPGNGPVAWARSLGLDVIDRVPFVKGLLMKGAEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQV3</accession>
    <name>A0A8G1VQV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_389626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520133.1">
        <property type="nucleotide sequence ID" value="XM_025656748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQV3"/>
    <dbReference type="GeneID" id="37160150"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000870">
        <property type="entry name" value="WD repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001043">
        <property type="entry name" value="WD repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="76"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH62211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="373" mass="39632" checksum="98510BCEE1D4CBDB" modified="2022-01-19" version="1">MAPPRRNLLPKDRFGLAFGGLKTQNYHDPAARGPGSHTIRTIAWNPTGQLIATGSADRTLRIWNPERSQVKYSTELRGHTAGIEKVVFNPVRDSELASCSTDGTVRVWDVRSKTCVSRLDVGGEAFTLSWSADGRVMIVGRKDDTLIPISVDTPSTPTIHPDGPPNAAATQQQQKPTFTPSIYTALEPHPQPIQTNATTFSHHISTPSSPDLHLFATTGEGTVKIISYPSFDVLHTLHAHTSACLSISLAPTGRYLAVGGSDALISLWDTTDWICKRTVSSNNGGALRGVSWSFDGRFICGACDEVGCGGNGLEIFHAETGESVHTVPTGGNANSGIPAVAWHPSRYWLAYSTTADGSGPGGLRIVGAAGGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQY8</accession>
    <name>A0A8G1VQY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_194731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519277.1">
        <property type="nucleotide sequence ID" value="XM_025654462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQY8"/>
    <dbReference type="GeneID" id="37157864"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH61355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="168" mass="18736" checksum="3744EE83FA513C83" modified="2022-01-19" version="1">MQLLLITTVHRIEALILLIALTPASEEFQKLVAFENAFDLIFSLIEAEGALTHGSEVVEDCLSLLANLLRLNISNQSYFRETGCVKRLAKLLADVNQDQDSEEPTPQWALAHRDKNLWGLLVIVQLFLIKGGVNTPANQTAFWNNGVMEQVLNTAFGQRFNVNVTSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR15</accession>
    <name>A0A8G1VR15_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_194817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519279.1">
        <property type="nucleotide sequence ID" value="XM_025654466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR15"/>
    <dbReference type="GeneID" id="37157868"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF19">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="594"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="643"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH61357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="721" mass="79710" checksum="91E29FA86EB207A4" modified="2022-01-19" version="1">MFMHPAARKGLITEPTSIPYLNYQDPVCIQDDQILDYSQEAALHFLGQQQPRLQTPFQYQPDLQFVSPPSSAPSSPTSSPASTISHYPATTAVAADYSSAVFDGNSFEAPSMTPSSSYNPSINIHHSASPPSQAYLPQYTQPYYFNGNPMLAQQSVANNHGWEGNLQLLGPARLQNNLLKASASPSSSRSAPAGSSYSRTNGAAKPLPTPVQTPVQSFQDGSQTDADLAMRRAILEQQQQQQQQQKQSRHQHQTSDYSLAPSVSSVSHNSPVTPHTGFEDLDDASKAIVNGENRFPDVDKWMDDYLRLDALSDYNNHNANNNMTIGIPKLNRTISDIYQDELYNPAMMSTPQMAKPATNQQNLLAPSFRNVIADRLQAANQGHLTARSQSPMVNMPRDRSPFRQNSPLAAEYNHAALQQPQMATSAPTSQNGVNMGQAAQGGEPKTMSPKDALLDFNEGDDTGLPLFPPSSQPDFNLGDALGLRRESSGSFQPTQNFTSMESFPSQYATQGATQQFAFGQQQNHRQAQQQNNNLLHQTPEFPASLPRFDSTGSDVLPSTEMTSPQASQKMPMQEPPVKEEISRPENTSADGGTYTCTYHGCTLRFETPAKLQKHKREAHRQTTPGGHLVTRDTSARNSQAGPHKCERINPSTGKPCNSVFSRPYDLTRHEDTIHNARKQKVRCHLCTEEKTFSRNDALTRHMRVVHPEVDWPGKQRRRGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR45</accession>
    <name>A0A8G1VR45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_464733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520626.1">
        <property type="nucleotide sequence ID" value="XM_025662005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR45"/>
    <dbReference type="GeneID" id="37165407"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034706762" evidence="3">
        <location>
            <begin position="20"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH62704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="402" mass="45402" checksum="90C8A70618C256A2" modified="2022-01-19" version="1">MHLKWLTLVCLPSWPSAWALYNQSTDFPDQDIDNGVALQQIINDSLENMKLESLATNGCRFEDAQIRKEWPPSHVQGRRSLSLAARKEFTDAIVCLQSLPANISAEEKETFQGVQTRYDEFVATHINLTEHIHVTADFLAWHRFFLYAFENALRFECNYTGTLPYWEWGLDAENPQSSVLFNGDPYSMGTNGVDMNRTSIYWESKNLSIPAGIGGGCVYGGPFSNYTVHMGPIDAPGEQPVQYNLEYNPRCLSRDVNPTISQMSISFRNTTKLILSYDTIDWFQGVMQADQRFTDPTAPFTYGVHGGGHLTVGSVLADIDTSPAEPMFWLHHAQIDRVWTIWQGLDPAKRRNAIWGTSTRGDNPPSANMTLDDMLDFGFISQPLKFADLMNPLSGPFCYYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR58</accession>
    <name>A0A8G1VR58_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">Glutathione reductase</fullName>
            <ecNumber evidence="3 17">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO85DRAFT_516122</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 17">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="14">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3 17"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519414.1">
        <property type="nucleotide sequence ID" value="XM_025664828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR58"/>
    <dbReference type="GeneID" id="37168230"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000141">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF1">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 14 16" id="KW-0274">FAD</keyword>
    <keyword evidence="6 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0520">NAD</keyword>
    <keyword evidence="8 17" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11 16" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="19">
        <location>
            <begin position="99"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="18">
        <location>
            <begin position="447"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="551"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="274"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="15">
        <location>
            <begin position="137"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RAH61492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="562" mass="60963" checksum="EBE814938D0D0689" modified="2022-01-19" version="1">MLSCPSLRPRPAQALKNRLLLSPTSSIRARSSPIVATPLLQGKGIATATPSTILPRQSTLALRSSSSVASRLSTVARHFSSSSSAADANNMAPTEVKQYDYIVIGGGSGGSGSGRRAAGWYGAKTLIVESGRSGGTCVNVGCVPKKMTWNFASINETLHVAKHYGYDVSENVDKNYRHFKEIRDSTIKRLNGIYERNWGREGIDLVHGRAGFVEPKTIEVTLEDGSKARYSAPHILIAVGGRPSIPEIKGAEHGITSDGFFEIEELPPKIAVVGAGYIAVELAGVMGAVGCETHMFIRGETFLRKFDPMIQKTMTERYEASGIHIHKKHPGLKEVQLIRDGKGKDKLLKLISNDGSEMEVNELLWAVGRLPEVEDLNLDVPGVKLNKSGHIEVDEYQNTSVDGVYALGDVTGHAELTPVAIAAGRQLGNRLFGPDEVRDSKLSYDNIPTVVFSHPEVGTVGLTEPEARERYGDDQIKIYHTRFTAMYYDVMPAEEKKKNPTEFKLVCAGPEEKVVGLHILGLGVGEMLQGFGVAVKMGATKKDFDSCVAIHPTSAEELVTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRE9</accession>
    <name>A0A8G1VRE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyl hydrolase family 43 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_9650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520778.1">
        <property type="nucleotide sequence ID" value="XM_025665818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRE9"/>
    <dbReference type="GeneID" id="37169220"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08999">
        <property type="entry name" value="GH43_ABN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF5">
        <property type="entry name" value="ENDO-ARABINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="6">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH62856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="407" mass="44352" checksum="C826F2594909555E" modified="2022-01-19" version="1">MKGLPSLLNSSTTIKKWTQSTPSTDTAEDEGQSGSTISPTKPPSADISSGGSKNPMIWTRRKITWLITLIALSVAIIVVVITVPVVLLVDDAHNDDPSYYNSANRPVRVVQDFPDPGLIQVNSTWYAYATVATPDNPDVPHVPVSTSRNFSSWDWLQGYDVMPAMSSWETNMNQYAPDVIQRKDGRFVLYYSGELKDWLRHHCVGAAVSNSTSPLGPYIPHNSTLACPRDHGGAIDPAPFKDVNGTLYVVYKVDGNSVGHGGDCNNGKKPIVSTPIMLQQLNDDGVTPVGDPVEILTNEKVDGPLVEAPDIIRTDRGIYYLFFSSHCYTSSKYSVKYAWSTSLKGPYTRAERPLFRTGDFGLKSPGGATASIDGSKIVFHAFCGDYRCMFAAAMNITANYTILPAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRI0</accession>
    <name>A0A8G1VRI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_444423</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521001.1">
        <property type="nucleotide sequence ID" value="XM_025659014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRI0"/>
    <dbReference type="GeneID" id="37162416"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF73">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="25"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="170"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="30"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH63079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="340" mass="35580" checksum="FA6DF995A4FA080C" modified="2022-01-19" version="1">MFAARQSLNLLQKRSFSASASQASKVAVLGAAGGIGQPLSLLMKLNPLVTDLALYDIRGGPGVAADVSHVNTNSTVKGYEPTPSGLRDALKGSEVVLIPAGVPRKPGMTRDDLFNTNASIVRDLAKAAAEAAPEANILVISNPVNSTVPIVAEVYKSKGVYNPKRLFGVTTLDVVRASRFISQVKGTSPANENVTVIGGHSGVTIVPLLSQSNHPDISGTVRDELVNRIQFGGDEVVKAKDGAGSATLSMAMAGARFADSLLKAANGEKGIVEPTFVESPLFKDQGVDFFASKVELGPNGVEKIHEVGPVNEYEQGLIQTALGDLKKNIQKGVDFVKANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRX3</accession>
    <name>A0A8G1VRX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_466795</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 10">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518140.1">
        <property type="nucleotide sequence ID" value="XM_025662151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRX3"/>
    <dbReference type="GeneID" id="37165553"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09617">
        <property type="entry name" value="Peptidase_C12_UCH37_BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000009">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="12">
        <location>
            <begin position="6"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 10">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="9 10">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH60218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="324" mass="36152" checksum="C86FE31C027EEA14" modified="2022-01-19" version="1">MADGGGWSTIESDEGVFTSLIENLGVKDVQFEELISLDADTIRSLSPVYGVIFLFKWTRETQQPSTSTSSTTSPPSGTYDTDPSPNLFFANQTIQNACGTQAILSVILNNDSSSSSSSSSNPYPINIGPELHSFKDFTAGFPPDLRGEALSNSELIRSAHNAFARASPFVDETVRNNQDEEGDVYHFIAYTPVDGKLYELDGLQPHPISHGGCTAEEFPEKVIEVLRQRIARYPEGETRFNLMAVVRDLRVTAKEIGDVEALEREERKRRAWAWENTLRRSNFVGFIGEVLKGVVGMKEKQGEGKYEEWVEKAKGETQRKLMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSH5</accession>
    <name>A0A8G1VSH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 12">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_410339</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 12"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520854.1">
        <property type="nucleotide sequence ID" value="XM_025657476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSH5"/>
    <dbReference type="GeneID" id="37160878"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000028">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH62932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="396" mass="44893" checksum="E6E1FA90D6C7F199" modified="2022-01-19" version="1">MAEFLRSQILGTTFETTNRYSDLQPVGLGAFGLVCSAYDMITRQPVAIKKMMKPFSNATLAKRTYREVKLLKHLRHENLIGLSDIFISPLEDVYLVTDLLGTDLNRLLTSKPLDGKFVQYFTYQLLRGLKYIHSAGVIHRDLKPSNILINENCDLKICDFGLARLQEPQMTGYVSTRYYRAPEIMLTWQKYGMQVDIWSAGCIVAEMLRGKPLFPGKDHIHQFYLITDALGNPPDEVIERICTKAALNIVKSLPKRQPAPWATLFPDSDEDAIDLLAKMLIFDPDKRISAAKALEHPYLGVYHDPTDEPVAEQKFDWSFSEVAHSIDEWKIMIYTEVVDFHDLGPTGEPAITEPFLPPDPSLSPEVLDPLGQIQTQSMVTKSADTLDQDILQYLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSR6</accession>
    <name>A0A8G1VSR6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_466448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519010.1">
        <property type="nucleotide sequence ID" value="XM_025662128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSR6"/>
    <dbReference type="GeneID" id="37165530"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="158" mass="17348" checksum="0AE930A63A734B94" modified="2022-01-19" version="1">MSFFPTTLPALPLREAIVDPVYRAVLSFDGNDLPLFESAFFEDAAFDFNGSVMEGRAAIKSGSWDNVSKLDTTHFLSNVRINLPSEDSTTATVTASALAQHFRTGQGNQPDTTRLTSGALYSIDVAKDPADVNGLWKIKLWRMKLVWTEGDWGVMTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSZ6</accession>
    <name>A0A8G1VSZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_435595</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519235.1">
        <property type="nucleotide sequence ID" value="XM_025658535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSZ6"/>
    <dbReference type="GeneID" id="37161937"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000012">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="48"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="11">
        <location>
            <begin position="248"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH61313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="455" mass="50881" checksum="C7D6C5325F5AC16F" modified="2022-01-19" version="1">MPREIITIQAGQCGNNVGAQFWQQLCLEHGISQDGNLEDFATEGGDRKDVFFYQSDDTRYIPRAILLDLEPRVLNAIQAGPYRNIYNPENFFIGQQGIGAGNNWGAGYSAGEVVQEEIFDMIDREADGSDSLEGFMFLHSIAGGTGSGLGSFILERMNDRFPKKLIQTYSVFPDTQSADVVVNPYNSLLAMRRLTQNADSVVVLDNGALSRIVADRLHVQEPSFQQTNQLVSTVMSASTTTLRYPGYMHNDLVGIIASLIPTPRSHFLITSYTPFTGDNIEQAKTVRKTTVLDVMRRLLQPKNRMVSINPSKSSCYISILNIIQGEADPTDVHKSLLRIRERRLASFIPWGPASIQVALTKKSPYMQNTHRVSGLMLANHTSVATLFKRIVQQYDRLRKRNAFLEQYKKESPFSDGLGEFDEARAVVMDLVGEYEAAEKEDYLDPEAGKEKEMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VUS2</accession>
    <name>A0A8G1VUS2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AIM41</name>
        <name evidence="2" type="ORF">BO85DRAFT_387148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM41 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VUS2"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="entry name" value="Uncharacterised protein YqeY/AIM41 PF09424, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="182" mass="19995" checksum="171438AECA82B19D" modified="2022-01-19" version="1">MLPSMRLTSRLGLRLVRWNSTAGPTLPPLMTALRTDLKTAMRAKDTPRLNVLRALISETNNAAKTNSPIQTDLQLLSLIRKRISASKDAAKEFESENRPDLKETEDRHIAILEEYGAQVKTMSVDDIKTIVAEELAKLKETGKKVEVGFLLKSLFSPGGALDGKPAERSEVARIAKEAISSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QP96</accession>
    <name>A0A8G1QP96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo-keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_482396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825096">
        <property type="protein sequence ID" value="RAH51701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509623.1">
        <property type="nucleotide sequence ID" value="XM_025663097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QP96"/>
    <dbReference type="GeneID" id="37166499"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH51701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="345" mass="38830" checksum="8A7A1065E4580BD6" modified="2022-01-19" version="1">MAMLSTRQLGENGPLVSAQGLGLMGLSMFYDKRLPDEDRLNFLDYALAKGVTFWDSADVYADNEDILAKWFRRSGKRNDIFLATKFGIKQHPGQPSSIHNSPEYVREACLKSRDRLGLKKGDAIDLYYCHRIDPIQPIEITVAAMAKLVDEGLVKYLGLSECSADTLRRAHRIHPIAAVQIELSPFAIDSLKNGLMDACRELGVAVIPYSPFSRGFLTGKLQRPDDLDENDRRRILPRFSKENFDKNLAIVREIEELALKKQCSVGQLTLAWISALYDRIIPIPGTTKSQNLDENIGSLRVELTEDDMEAVNRVAFSADIQGDRHPKSMVPYLYVDTAPLKETEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQE0</accession>
    <name>A0A8G1QQE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_464549</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825096">
        <property type="protein sequence ID" value="RAH51684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509606.1">
        <property type="nucleotide sequence ID" value="XM_025661993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQE0"/>
    <dbReference type="GeneID" id="37165395"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="47"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="482"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH51684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="520" mass="58474" checksum="216D01873A99102E" modified="2022-01-19" version="1">MTRDTEANSSQEHNIVRPLKSWKGYIWDTWELPSDQRWLLFKLDAFVLTFASIGYFLKNLDLQNVTNAYLSGMEEDLEMFGNQLVTSTSIFTVGYVIGQIPANLLLTRISPRWVIPSLEIGWGIATMCMSSVKSYKALYALRFLVGLFESGFYPGIHYLLGSWYTPQEIGKRAMIFWLAGHIGNLFSGFLQAAAYTNLNGVDGRAGWRWLFIIDGIITLPLALAGYLFFPNLPQSGKKTWWITNEEHILSVNRMQAIGRAGKEPWSMAKLKRILYSWHTYLLPMIYILWNNGYPQVGMGYWLKSFNADPPPVPGKSYTVADINNLPLVTTGISIFVCFIWGLLSDGPCRGSRWPFIHIGAVITLVMCVLLRQMPLYTNIPGRMAVYWLSNIGVGAGPLILSWVNEICSADTEKRALIVAMANDLAYVVQAVAPNFVWKTTDFPAAKKGYLWSIILQILLMVVTGTVQFLLWWDRKRETQSHEAVEPIADSDADSGPASSKYGSVDAKKTPQTQITPVNSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQX7</accession>
    <name>A0A8G1QQX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_493266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510105.1">
        <property type="nucleotide sequence ID" value="XM_025663820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQX7"/>
    <dbReference type="GeneID" id="37167222"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="135" mass="15532" checksum="231ACCA59C7FF9D9" modified="2022-01-19" version="1">MVRLPTEILEMIGTFVDDKPTQRALTESSVEFHTLFTPRLYSSITLPSIWTPVQFDLIRRLCSSPELASLVRHFAFRIGGYDDYGKDELPPRRKEYKPFIDELVAALCELGCDEWVWWDGLESLSKDAWACATLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRD2</accession>
    <name>A0A8G1QRD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1275 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_443403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510109.1">
        <property type="nucleotide sequence ID" value="XM_025658875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRD2"/>
    <dbReference type="GeneID" id="37162277"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF6">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G07550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="302" mass="32727" checksum="6D561C5BFCFDB4A5" modified="2022-01-19" version="1">MQSYPSEDIQPVPQARTTNRGHLQFAEDKGGLWSSGNSTNVSLSVGQAVEGGLYATMTRHFKAEIDTRYADIVLIVCGFVSGLVDGLSFNAWGSFSSMQTGNTLFIALGASGQPRYPAYLWAKSLIALCTFISSNVIFIQVARRLSPRRRSTMILSFATQTICLLAAAILVEAKVVSPKPEDPRAPIQWMQILPITLLAFQAGGQICASRILAYDEIPTVVLTTLLCDLLVDPDLLAKRNARRNRRIGAFLALFLGAMTAGGLSKVATMASSLWFAFGLKFTITLSWIVWRAEGGSKAGDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRU8</accession>
    <name>A0A8G1QRU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phenylacetyl-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_481227</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511078.1">
        <property type="nucleotide sequence ID" value="XM_025663048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRU8"/>
    <dbReference type="GeneID" id="37166450"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="457"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH53156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="567" mass="62170" checksum="1636720DD3915C47" modified="2022-01-19" version="1">MPVSSRYPPVDIPDLDIWSFLFERKDKPFPDDKVIYQDADTQRSYTYQQVKDAALTFGKGLKATFDWKKGDVLALFTPNSIDTPAVMWGAIWAGGIVSPSNPAYTAEELAFQLKNSGAKVLITQAPFLPVATAAAKEAGIPEDGIILIGDQRDPQARIKHFTSIRNISGATRFRKPKVNPSRDLAFLVYSSGTTGVPKGVMLSHRNIVANILQLAEGEAGNLTWNGGVDGTGDRILAFLPFFHIYGLTCLLHQTIHKGLHLYVMTKFDIEQWCSHVQNYRITFSYVVPPVVLLLGKHPIVSKYDLSTLRMMNSGAAPLTQELVEAVYARIKCGIKQGYGLSETSPTTHTQPWEEWRSTIGSVGKLLPNMEAKYMTMPEDASEPVEVPAGEVGELYMRGPNVFQGYHNNPAATAECLSEDGWFRTGDVGYQDPQGNFYITDRVKELIKYKGFQVAPAELEGILVDNEAVDDVAVIGVESEAHGTEVPLAYVVRSAKSLNSGVSAAQEAENIVKWLDGKVAYHKRLRGGVNFVKEIPKSASGKILRRLLKKKAKEEGVGAGAAGPKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS72</accession>
    <name>A0A8G1QS72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_199815</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510529.1">
        <property type="nucleotide sequence ID" value="XM_025654519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QS72"/>
    <dbReference type="GeneID" id="37157921"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14096">
        <property type="entry name" value="STKc_RCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000425">
        <property type="entry name" value="Putative calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="105"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="568"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="250"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH52607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="633" mass="70789" checksum="07A431295D357CDE" modified="2022-01-19" version="1">MSTIQSLKNFIRHGKQARLVTPHAEPTTNVSPIHAEQQRQPQGSYPPAAGNLDAIDSRMGNGQAQPSQKNSDQTRRAREAELEQIIAEEKSSRNKMPRYPGLERYTLVEKMGDGAFSNVYRARDSTGEYGDVAIKVVRKFEMNSNQSSAHLHPGLKKKPKATERANILKEVQIMRQLDHPNIVKLVQFSESRQYYYIVLELCPGGELFHQIVRLTYFSEDLSRHVILQVAKAIEYLHETSGVVHRDIKPENLLFYPIDFIPSKNPKPRQPGDEDKVDEGEFIPGKGAGGIGVIKIADFGLSKVIWDSQTMTPCGTVGYTAPEIVKDERYSKSVDMWALGCVLYTLLCGFPPFYDESIQVLTEKVARGQYTFLSPWWDDISKSAQDLISHLLTVDPEKRYTIKQFLEHPWIRQTDEATEAAADAPPLATPLTTRKTQQLDAFAADQAPYAPASARLMDPASAGLERPMDFRSPGAINLREVFDVGYAVHRQEEEGKRRKNFRQGYRGANPSTAFQSALNPLNEDYDEAEEITYQPLPREDFPPAKIPKASQQASDVAAMEAKLRSTNLGAPSHAAQARQAHQPRQQQGYGQHSAKVAAAAKQSIARGAREPFELSLDNATLLEKRGRRQQGQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSC4</accession>
    <name>A0A8G1QSC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine synthase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_463482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510885.1">
        <property type="nucleotide sequence ID" value="XM_025661931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSC4"/>
    <dbReference type="GeneID" id="37165333"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000058">
        <property type="entry name" value="Cysteine synthase B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="389"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="538" mass="59197" checksum="A02666431AAC3D66" modified="2022-01-19" version="1">MANINEHNVYFGPDALKKYFDPDCQPPLPLVELPDRLNPFHQDGVRIYAKMMTMHPANNVKAIPAMNLLEKTVVPGKTKTIVEFSSGSTVISMSMLARLMHGISDTRAFLSNKSTETKLRMMQFFGLDVTLFGGPSQPDPLDERGGIQTARAMAMGSEEIVNPNQYDNDDNWRAHIRWTGPQIFKQLPEINVLCAGMGTSGTMTGLGTYFKEIKPSVLRLGVCTAPGDRVPGPRTFALMQVQEFPWREALDVHEEVSSYDAFSLSLDLCREGVVCGPSSGLSLKGLYQMLEKRKMAGTLRQLAGPDGSIHCVFLCFDLPYQYVGDYFEKLGPERFPPIRNQNLVGVDLYRYDESWERSPVVLFTDYYEIPQCFSTHPLSAMVLRPLRCVLDLRTAGDFGTWHLPGSVNIPLHSLDSHTAKPFSDADVLEAQWLELEALFSNADVLGKLSGHQVLMLCYHGDTARVASSVLRAKGIAADSLRGGYQALKDHLLWGSSNGVDSNQMGKAATATVEAVDAAAEDAVVAAAVETAVVVTDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSF2</accession>
    <name>A0A8G1QSF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BNR/Asp-box repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_453404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510930.1">
        <property type="nucleotide sequence ID" value="XM_025661045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSF2"/>
    <dbReference type="GeneID" id="37164447"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792:SF3">
        <property type="entry name" value="BNR_ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="377" mass="41638" checksum="D5FFD27D427ED6B7" modified="2022-01-19" version="1">MPGHFGQKILNTLGIDHHGHHGHGQGQPYQQPPPPGDNRLAGNRVIHNDERLLSPHPAGTYPRLARLHDGRILASFTRFVGDGERVLMVSISEDNGQTFTDHGEITRGKGDVDNVYLLEIGPGTVLAAFRNHDIGPGGPTHFRITVCRSTDAGRSWSFASQAAEKPAPMGIWEPFMRLGRRPGEIQLTYSQEFAHNNQCTMLVRSYDGGSSWSAPQCLHGAEDQRRDGMNGIARTWDQARNCEALVMVFETTTYGTFDVEALVSYDDGETWGGRQQVYVPAQGHNAGAPQIASLGDGSLAVIFMCDEDFDEVNWTKNACVKVVFGSMPHEGRIMWTRPTTVCRDSSHWPGIFTLDDRRLLALYECGGPKAKTIALEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSL8</accession>
    <name>A0A8G1QSL8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_492729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510754.1">
        <property type="nucleotide sequence ID" value="XM_025663792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSL8"/>
    <dbReference type="GeneID" id="37167194"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="60"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="206" mass="22165" checksum="C92B697F49BD9F32" modified="2022-01-19" version="1">MSRFPAIPPDQQTAEQSLVEPSARRIFSHLPPEVQWQGPSGVILGPYSPLYYTPSIIKPWFSFAYSIGSQPHVTAREKELAILATLAEHKAPYVQYAHSHSARAAGFSHEQIAQALQGQHQQQPPPAGLSEAEQAVYMAALAMARSRGPISTEDFDAAVAALGREKVAEVAHVVGGYMYVCLLSNLANEAVPSGDAVGEKDGTDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSZ0</accession>
    <name>A0A8G1QSZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA repair protein REV1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Reversionless protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_240993</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825095">
        <property type="protein sequence ID" value="RAH51705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509627.1">
        <property type="nucleotide sequence ID" value="XM_025654842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSZ0"/>
    <dbReference type="GeneID" id="37158244"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01701">
        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000040">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="17">
        <location>
            <begin position="61"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="18">
        <location>
            <begin position="375"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="197"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="749"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="833"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="892"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1007"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1120"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="749"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="770"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="837"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="897"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="908"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1019"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH51705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1170" mass="128520" checksum="42FC8C25B10817A4" modified="2022-01-19" version="1">MGSRLHENSSAVRKRIQNHHFDNEAGEEYEASAFGGFSDYMRRKKIKLQNRDAEIRSSAANCPPIFRGVVAHVNGYTQPSLQDLHRLIVSHGGGFLQYLNGKTDATHIIASALTPKKREEFRRYRIVKPAWVVESVKAGRMLPWDSFRVVDEGQSQKVLRFDDGRMVSQMNSPRSGYREQTDTSWYTNQLQEAALSVENADVQRSPPTHSEILNREDPSPHNGSQSDYSQFPSFASLDEVSRTPNISSPREEVRAETPDKQSPVEDEDINTHSNKQENDQTEAPSAALPLLRESFPTKPAMTSEEYNAQLLSDPHMRNSSVANPQFIQQFYSESRLHHLSTWKADLKAQLQSAAKEKSLSQVKRKKPAPGARRYIMHVDFDCFFAAVSTLKRPELQGKPVAVAHGTGSGSEIASCNYEARAHGIKNGMWMKGALQTCPELKVVPYDFPAYEEASRKFYSAILSVDGIVQSVSIDEALVDITTQCLEAGGSDGRGISEGSLYREQARADEIADDLRATVKKETGCAVSVGIGGNILLAKVALRKAKPAGQFQLKPDAVLDYIGNLTVQDLPGVGYSLGTKLEDLGVKIVKDVRELTRDRLTTSLGPKTGIKIWEYARGIDRTEVGNEVLRKSVSAEVNWGIRFVNQTQAEDFVRSLCQELHRRLVENLVKGQQLTLKVMRRALDAPLEPVKHLGHGKCDVFNKSVALGVATDAADILGKEAVAMLRSMNLSPGDLRGLGVQMTKLQHLQAGSPSKSGQRQLNFKASPVSKSIERHDPDILDSPRKGETESVKPVPLFSESSRLLNVSGTQFILPSQTDPEVVAELPNDIRSRLIAQGRPREESRSESRSESPCPTGRTWAPAPAELPPQSELDPEALAALPEDVRAEILGYYSRPSVSPGPQPTPPSAAPLLPSRPSSAGGLMMRKPTSPPKKRRGRPSTKSVGNPAFTQARFVIPRATASSSAPAERHSPPPEQTDASADFLAALPEDIRREVLQEQQRTKILQRPALNPASVPRAASPMTSDSTTVPATDPPSIPEKRLVLPPLPDRPTFTSQRLTNLSDLRDAMSSWHEAFSSEGPFEEDVLSVGRYLKSVIVDEKDLDKATSVLSWLAWLVDDEQDAKESDAFKTPDPSGRTGSSSQTAMAWEAAIRSLRASVDEGCAERGLPSVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT48</accession>
    <name>A0A8G1QT48_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_463354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511024.1">
        <property type="nucleotide sequence ID" value="XM_025661921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT48"/>
    <dbReference type="GeneID" id="37165323"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034181342" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="373"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="479" mass="50347" checksum="E77DEA3994C34CC0" modified="2022-01-19" version="1">MNAFIASALLLATGSGVNGLEFEIPSSAPANSSGQLDAAPVGVSFEFFAFPEYFQQLPLTNSCLGQLHDASGSYSPIRIGGTTQDRATYNASLSSAVSYSVDSPDDAPETLTFGDSFMEIAGTYEGSVTIGLNRRLDNIDNTIAAAKVAKSEVATLYAIELGNEPNFFTSSDPIADGQSWTAAADAASQVSWQASVGSALDETSFAQAGVFFGVGTFNVSNLAQKEEEADTTQYVRSFCHHYYPQSASTADLDELMSHTEIVEGVAEFQSQVVAAQELDKDFVMGETNSATGGGGGISPTFGAGLWILDYVMQATILGVKQLFFHQGTIGNCPYCWWDESVNAPFYGAYTAALALSGASKVAQLDTGNSRFAAYAFYDSSNQPIRVLLYNSEYYTSGTRSSVSVTLSGIPSTSTSVSALRLTGDAATTTVGEGAITVGGQTFANATCELQGTKDTETMQATAGRATFTVQASEALLIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT95</accession>
    <name>A0A8G1QT95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_454424</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509792.1">
        <property type="nucleotide sequence ID" value="XM_025661284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT95"/>
    <dbReference type="GeneID" id="37164686"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.550:FF:000006">
        <property type="entry name" value="Microsomal glutathione S-transferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH51870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="152" mass="16699" checksum="9DAF70689A675FBC" modified="2022-01-19" version="1">MLTLTVPENYGSVIAVALGAIPVLSFVHGAVVSRLRKHADCPYPHCYATVEQCKTNPKAEQFNCAQRAHANFLENSSQTMLFILVAGLKYPQLATGLGSIWVLGRSLFLYGYVYSGKPRGRGRLYGSFYLLAQGALWGLTSFGVARELISYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTK3</accession>
    <name>A0A8G1QTK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_472479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510588.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTK3"/>
    <dbReference type="GeneID" id="37165958"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="183" mass="19534" checksum="9CE7AE29A85FDC26" modified="2022-01-19" version="1">MPSPATTSPFGFMAQYQAKGLITDEGFKAFRDAYTGHLPDVKMYVAEEDGMHVFYYNAGLETGGAVFRTNRADAVASILHMVQDNGGEIEKVSIDVLGARAGLEVQTLNDYFPVYAGADATAHLVDLKGGPCYGTLGVGVDTELGYRDQSVGCKVLGCGMRVGRVCEISAFGSKIGIDWGKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8G1QU20_9EURO</name>
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        <submittedName>
            <fullName evidence="5">L-fucose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_206785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510167.1">
        <property type="nucleotide sequence ID" value="XM_025654577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QU20"/>
    <dbReference type="GeneID" id="37157979"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF3">
        <property type="entry name" value="PROTEIN TSGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="445"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH52245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="487" mass="53026" checksum="AE511F1DB85E03CC" modified="2022-01-19" version="1">MGFLNFLKTRSGFRVDNSRTTSAATLTLRQSLWPLTLVTILFFLWGFAYGLLDTLNKHFQNTLNITRTRSSGLQAAYFGAYPLASLGYANYILRHFGYKTVFIFGLTLYGIGALCMWPAGLNRSFGGFCAATFVIGSGLGSLETAANPYLTVCGPPKYAEIRINLAQAFNGIGTCVAPALASYVFFTSTEDDVNALKRVQWVYLAIGIFVFVLAGVFFISTIPEVTDQDMAFQVAETHVGEQDKPFWKQYRLFHATLAQFTYTGAQVAIAGYFINYVVETWPGTTSATGSKYLAGAQGAFAMGRFLGAIIMRFVKARWVFLAYLSLTVAFIAASITQRDQKGIAMLFCTLFFESVCFPTIVALGIRGLGRHYKRGSGFIVGGVSGGAVVPPILGHVADMRNSTGFAMIVPTMFMVVAWTYALAVNFVPAYRDMVDKVGESEIGLRDEAASVSPKDVESGGGGGHGLTDMEKEKGEETAREEYTTTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QU42</accession>
    <name>A0A8G1QU42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_491814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511610.1">
        <property type="nucleotide sequence ID" value="XM_025663739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QU42"/>
    <dbReference type="GeneID" id="37167141"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="72" mass="7831" checksum="ABB27625DD91A84A" modified="2022-01-19" version="1">MSPPISATAQSSAYGVSLRECLFVTAIRAADDKESDYGFRMWTAVDSSSIHTFFDRAVLAQGKKEATVNRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QW40</accession>
    <name>A0A8G1QW40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_161660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="37157640"/>
    <dbReference type="Proteomes" id="UP000249526">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="135" mass="15601" checksum="4B91199F120B019C" modified="2022-01-19" version="1">MRWADALKRRLRYHVIKFRIIFNYIFLLLCKNGLVVPIILTTVANDASLSSTWYFYLVWFSAAISLLCLAPNLTYALLNIYLHPPVTVRASRGLRWIFPLASSCMGDHPTVKKRRQTIIRISLFGGTIRMIDLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWB5</accession>
    <name>A0A8G1QWB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose receptor Git3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_381590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511292.1">
        <property type="nucleotide sequence ID" value="XM_025656428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWB5"/>
    <dbReference type="GeneID" id="37159830"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023041">
        <property type="entry name" value="Glucose_rcpt_Git3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11710">
        <property type="entry name" value="Git3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose receptor Git3-like N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH53370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="285" mass="32090" checksum="DA681FC0CC30616A" modified="2022-01-19" version="1">MESEEVLSQIILVVSVVSMVGSGWIIISFLFIPSLRTFRHQLILGLGISEFLAASNVVVPAGLNTSGIEIWNPSLKTFCSFSGLMAQTFLVQILLADYWILSIAICTHLILMDYVHAASWVQNHKAALWCIPWGLSILWAVLGLVIVGYGYAGGWCWFTSDRVRLFVNFIPRWTIILVILCIYTRICVFLYRSHKALSSDQEVTLQTPHPHQWQLLDIDDGPSHTSHSSIPLKKVSLQMMVYPTVYAMIWIIPTSVRIYQGMTGKRAPLALEILEKVIEENDGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWC5</accession>
    <name>A0A8G1QWC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_461246</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513538.1">
        <property type="nucleotide sequence ID" value="XM_025661772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWC5"/>
    <dbReference type="GeneID" id="37165174"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000063">
        <property type="entry name" value="MFS multidrug transporter, putative (AFU_orthologue AFUA_2G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF7">
        <property type="entry name" value="DRUG_PROTON ANTIPORTER YHK8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="115"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH55616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="544" mass="61024" checksum="7DFC8EDE69242AC1" modified="2022-01-19" version="1">MSSATERAESSQESTEVEKLEDNVDGMFAPITARNSSYEERLRRHHSASSHPLERNWSLNDGYSIQNADEEAVAERVLSNKDEEASDASEGFVVSWDDNDPMNPRNFNTVRRWLIVIICSAGSLCVTCTSSMYTVTYDQIMEEFGCSREVATLGLSLFIWGLAVGPLLLGPLSEFYGRRRIYICSFTLFLVWLIPCAVAKNIQTMIVCRFLNGIAGSAFLSVAGGTVGDLFARHELSAPMMLYTSSPFIGPEVGPLVGGFINQFTTWRWTFYVLLIWTGVLLVLIGFFVPETYHPVLLRRKAQQLRKETGDDRWIAPIEMMDRSVAQTVLRSIYRPLLLLTLEPMCLNLCIFSAILLGILYLFFGAFQLVFESVYGFELWQRGLCFLGLFVGMLFAIFSDPFWRRNYTRLELKHQEAVGRSDDFQPEWRLPPAIAGGPLVTVGLFIFAWTIYPQVHWIAPLIGSALFGAGTILVYSGIFTFLVDAYPTYAASALAANSFARSIFGGVFPLFGIQMYNNLGYHWATSLLAFLTLVMAPFPHNGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWU3</accession>
    <name>A0A8G1QWU3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_453728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510747.1">
        <property type="nucleotide sequence ID" value="XM_025661117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWU3"/>
    <dbReference type="GeneID" id="37164519"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="75" mass="8176" checksum="88E5BB670B7E722E" modified="2022-01-19" version="1">MLHEQQQQQQRKINKAGLTRLPSRLLNHTLMLTFGGASSHQGFGIIDAPVGNLRQAPQLPGNRDVSAMNKSLATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWW3</accession>
    <name>A0A8G1QWW3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SUR7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_383005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510777.1">
        <property type="nucleotide sequence ID" value="XM_025656492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWW3"/>
    <dbReference type="GeneID" id="37159894"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414:SF1">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033989486" evidence="2">
        <location>
            <begin position="27"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="239" mass="26302" checksum="A831453DF3E68F50" modified="2022-01-19" version="1">MGFLGLFFTAGALLLMFLTLLGGARNSRPLNEIFFLQVDTSNIPGAPSLSRWTFWEICAVSANGKNQCGSSYPDFPFDPPSQRNFGTTENIPSAFIGTNHYFLTSRFSFPFLIIALFFGVVSLFTGFLAMCTRIGSYVSSLMAWIALVFQIITTCLITAVYVQGRNKFNANGQSASVGVKAFAFMWTAVACLMLACMFYCMGGAVGRKERGYSGREHRRRGFFSSARSNSVRSNKETAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY36</accession>
    <name>A0A8G1QY36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative efflux pump antibiotic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_381268</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511377.1">
        <property type="nucleotide sequence ID" value="XM_025656408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QY36"/>
    <dbReference type="GeneID" id="37159810"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="9"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="501"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH53455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="540" mass="57409" checksum="32C5B940529F63F9" modified="2022-01-19" version="1">MSKYQFIVTILALLLAMLLTALDLTIISTAVPRITHDFHSLNDVGWYGSAFFLTMCCFQTFWGKLYRYCSIKYIFITAILSFELGTLGCAVSKNSAGFIAGRAVAGFGGAGVISGTYIIIAHIVQPEKVPVFYGLNGIIFTIASVAGPLIGGAFTSTVTWRWCFYINLPLGGVAVAALLLSLRLPQSRRPAPTPVLEILLKLDLPGCFVMTGALICYLLALEYGGITKPWNSSQPIGLLVGWILLTLLFAAVEWFQGDEALVASRYLRNRGVLMCCIFVFFLNAANYIRVYYLPLYFQAIKYASPERSGILLLAYIVPTSVFTMLAGGVLNKVGYYQPFLLAGAGTVTIGSGLIYTLDINTPSAKIIGYQILAGAGDGICVQVPVTAVQAFVDQKELATVTALVLFFQLGSGVIGIAAGESIFSNRVIQKLAQYAPGTSATAVLEAGASELQSAFGEAELQGVRRAYLAGIHGAWILTLALCGAAVVAGVLAPPISIAGKTGVRPTTEGDGDSKRRPTDEMGEEERGEVDGAGVSDCKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYK6</accession>
    <name>A0A8G1QYK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cora family metal ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_64123</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514215.1">
        <property type="nucleotide sequence ID" value="XM_025665552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYK6"/>
    <dbReference type="GeneID" id="37168954"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="581"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH56293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="632" mass="70941" checksum="FA9829480023540A" modified="2022-01-19" version="1">MSIYSQDHAQSAAGLQSSQDIADIEANPRTPNPPISPTSKAPPSPPPETFTTAARLNSRETVRNRLRRSTTARSYYREDGALDPNWQPGTEPGIDPSQPLPAYSTEWMASTPAELHGTSEITVVDFSQHEMRQYVLDNDTLEPFLAREREPWVQCRWINVNGLSWDAIRILGNEKGLHRLAIEDLINATNRTKVDWYSDHAYIVLKLQKLIKLKEDDSDSEDEEDENTHWTNERKSSASSISLRRPTKRTLVLEALKDLFRPKTREDSPDEQYPGKDAPSGRGNSTSKASNIDDGANVKFTPRSIQRYRGGPNEDRIAFMERHAILAAKGLCVTLEQVSIFLHADNTVTSFFETSADDIEGPIVRRLSTPETMLRQSCDASMVVQAILDAIIDLAIPVTTAYQDVIGDLELEVLTDPDVDQSKSLYVLTSEIAILRNCMQPIATVINALRDHRSDPVHTPGLGVLRNVGTATPTNDWSPYIGTATPNLKSLSGSSVSISPMCHTYLGDALDHCITIVEGYDQMRRAADNMIDLIFNTIGAYQNESMKQLTIVTCFYLPLTFLTGYFGMNFTSFAGIEHSDAYFWMIAVPFVFVTTIFLMRDKLQRYLVLLAQKRLITSSRRSRQRRRATERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYR0</accession>
    <name>A0A8G1QYR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_489427</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513949.1">
        <property type="nucleotide sequence ID" value="XM_025663605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYR0"/>
    <dbReference type="GeneID" id="37167007"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08650">
        <property type="entry name" value="DASH_Dad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH56027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="50" mass="5704" checksum="D984A6D8AD2C88A0" modified="2022-01-19" version="1">MVMNRSLQEVNIQNMNVELVAQMFKNYQSNVLFHLEATENLKDPSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ26</accession>
    <name>A0A8G1QZ26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_81790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513166.1">
        <property type="nucleotide sequence ID" value="XM_025665702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ26"/>
    <dbReference type="GeneID" id="37169104"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="393" mass="43945" checksum="CDE8529C3BDA0A30" modified="2022-01-19" version="1">MATVTFKDDLPNTTTTTTPKNKTTTLRRWLTFSTSTSSSHRRRRRSSSPRPKPTRRPTPKPTINTTTSTSTSTSTTTRLYRRVTLPRRSSKSKTKTRTIIHPDDDTQPTSLLTSINTTTNTGTPTAHPTDTTNPITPPPTSPTSPSSTTNNKIRARSPLSPLSPLSLNFSTLFNLSPRSKTIEESSSSSSTYSSSSASEIHIPPPTVSHEQLTSSYAEYCEAFTEGRTEESFLYQEEKEGEEYGDKGVRPVKEIVIKGEKGCLEERCRGKEGVGGGGQCVVDTKEEETKENGDGDRAIPCSDDQREILHWLRESDEEEQDSGSNAEDVPLRVSPPARILTPARYEQSRRAARQPQHGKQEHHEDQRHAWWTALRVGWTRMRRRTSRAANPDYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZD8</accession>
    <name>A0A8G1QZD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_84113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513316.1">
        <property type="nucleotide sequence ID" value="XM_025665724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZD8"/>
    <dbReference type="GeneID" id="37169126"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="202" mass="22635" checksum="25CB0D6EBEA9887F" modified="2022-01-19" version="1">MVVDRRSIIGSPKASTSTGNKPSRALIRVDNNAYSTWSQAEMQPWKPELRASHPPPFSSFRSAFNSTSSFQFRLIDWGEINSQKCERCQGRHVKSLIIHLPASVPSHGSAYSLVGCKMRLVSSLHTPEGHLHISFPHPLLFSLFPHLFWPLLKLLKKLYSRAPGPMDCHFPRILQSANAIPSLLLLLLLLLPTITSLYLSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZR7</accession>
    <name>A0A8G1QZR7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_452668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512232.1">
        <property type="nucleotide sequence ID" value="XM_025660876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZR7"/>
    <dbReference type="GeneID" id="37164278"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="281" mass="30734" checksum="2584DC1611E285D2" modified="2022-01-19" version="1">MNPSPAMMPTTLPTMSSESPKRKRASPEDSDYRSPSASPTSSGSIPNPQESKIREAEDWGRYSPRALVAGRLGRLAIRGDQFSTSPVPYGVDQGIVAHTAQSGNWPTSDGDSHDSYAVSEANASMEISPSPGGLSEFAEATQSPEIARTGSPSPRKRRSTPSPRKKKLPTASSTMRSRSASPPLITDTAENPLTWHDSEITGHNPTDPTDDGYGLNGIGFKPTAAMAWARSERRKKQVAEWRSREAREAREKRRERRDGADFERIRSIQSGAIQKRVKFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R065</accession>
    <name>A0A8G1R065_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_372783</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515025.1">
        <property type="nucleotide sequence ID" value="XM_025656056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R065"/>
    <dbReference type="GeneID" id="37159458"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000006">
        <property type="entry name" value="mannose-P-dolichol utilization defect 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="264"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH57103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="300" mass="31331" checksum="454A40BAA7EFFB0B" modified="2022-01-19" version="1">MDAIQKTIIDPLQPLLRPVASALPEPVHDAIISLIGSSCHNSLVVDLDVSKDPACTSLAISKALGIAIVGASGIVKVPQILKLISSRSSAGVSFVSYALETASLLITLSYSVRNQFPFSTFGETALIAVQDVVVGVLVLTFAGRSAAAAAFIAVVAASVYALLFDQTLVDAQTMSMLQAGAGALGVASKAPQIYTIWREGGTGQLSAFAVFNYLAGSLSRIFTTLQEVDDKLILYGFIAGFTLNLILAGQMLYYWNSPAKSQKKEKPVAAPTPVKAPVTATSSGVSPKPSGKTPTTRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0I1</accession>
    <name>A0A8G1R0I1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_450009</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515205.1">
        <property type="nucleotide sequence ID" value="XM_025660285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0I1"/>
    <dbReference type="GeneID" id="37163687"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3710.10:FF:000005">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000029">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="27"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH57283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="531" mass="57957" checksum="0F3EC39970C6A776" modified="2022-01-19" version="1">MVSCPICSQSVSSLKINDHIDSDCQNFIEEPSSSGETPATQKAAVPSFFQPASAKKASAQSAQANGQRDQNVTSSPLRNGNGKRATPHDANSSEVYERSGPSQPASEPKKPKVSALQKAAPLPERMRPRTLDDVCGQELVGPNGVLRGLIEQDRVPSMVLWGGPGTGKTTIARVIASMVGSRFVEINSTSTGVAECKKIFSEAKSELSLTGRKTIIFCDEIHRFSKSQQDVFLGPVESGQVTLIGATTENPSFKVQSALLSRCRTFTLSKLTDEDIRSILHRALRLEGPNYSPSELVDEELIDYLAKFADGDARTSLNLLELAMDLSKRPGINKDEIKRSLTKTLVYDRAGDQHYDTISAFHKSIRGSDPDAALYYLARMIQSGEDPLYIARRLIVVASEDIGLADNSMLTLAISTHSAVEKIGLPEARINLAHATVAMALSKKSTRSYRALNNAFAALAEPGVAGLPVPIHLRNAPTRLMKELGYGKEYKYNPNYVDGEVVQDYLPEQILGRKFLEDRDLGHQVDPDLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0U8</accession>
    <name>A0A8G1R0U8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DlpA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_520755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515231.1">
        <property type="nucleotide sequence ID" value="XM_025665159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0U8"/>
    <dbReference type="GeneID" id="37168561"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="114"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="239" mass="25297" checksum="D2E6F9C1E698D4CB" modified="2022-01-19" version="1">MSILEEKISLLYNYSACDVSDALLKLQPVPPNTPPRAGYIADLTPYYPPTQDPSSTTPPKLIAPASTLQFIPKSTPTPATSKAIPPSTHWSDLTTPSTILVISQPGDQHCAVVGGIMALRMKVRGVLGVVVDGRVRDRAELKASGLGIWARGGSTVGSGAEAKAGEMGGEVCVSGVVVKEGDIIFCDYEEGGVVAIPREMLDRVLEVMPKLVGMDDKVKEAVEGGMSVFEAFGRFRGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R268</accession>
    <name>A0A8G1R268_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_450440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514352.1">
        <property type="nucleotide sequence ID" value="XM_025660376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R268"/>
    <dbReference type="GeneID" id="37163778"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07105">
        <property type="entry name" value="ALDH_SaliADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF2">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G05520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH56430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="483" mass="50925" checksum="A2E8CE0612D556CC" modified="2022-01-19" version="1">MAAPPRPPVIPLIINGQEECTGSTFDVISPYTNQTCWTTASASAQDAIRAVEAAEAAFPSWSQTKPTVRRDLLLKAADILESRLEQNAEYMRTEMGADVGASQHFIVPLGIRMLRDIAGRITSICGSVPVVEEEGQSAMIYKEPMGVILGIVPWNAPYVFGVRSAACALAAGNTTILKSSELSPCSYWALARAFHDAGLPAGCLNLVSCRPQDAPEVVNAMIEHPAVRKINFTGSTAVGRKIAGACGQNLKPCLMELGGKNSAIVCADADIKTAVKGVLAGAYLNSGQICMATDRILVHSSIAPVFIEALKEALTSSVDPASQPPTLVNMASKARVSNLVKDALAGGAHLIHGSVDHDSAQSDNGVRMAPVLLGGVNEKMAAWQEEAFASLAACMIVESDEEAIKIANGSGYGLSAAVFTEDLRKGLAMARKIQSGAVHINSMTIHDEAVLPHGGVKNSGWGRFNASQGLEEFLVTKSVTWMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R301</accession>
    <name>A0A8G1R301_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_449335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516154.1">
        <property type="nucleotide sequence ID" value="XM_025660144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R301"/>
    <dbReference type="GeneID" id="37163546"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307:SF6">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25788">
        <property type="entry name" value="Ig_Rha78A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial alpha-L-rhamnosidase N-terminal" evidence="5">
        <location>
            <begin position="156"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase concanavalin-like" evidence="4">
        <location>
            <begin position="338"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="6">
        <location>
            <begin position="446"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="7">
        <location>
            <begin position="800"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="922" mass="103433" checksum="0F3C0F0A5F385BC4" modified="2022-01-19" version="1">MTSQILIETPTVEQHSTGFGIGTATPRLSWRFLTTDSSPRDWEQTAYEVEVVRSGSRKETYHVNSNASVLVPWPSGPLQSREIAQVRVRAYGCSAGEEQHRDCATAWSPWRIIECGLLDRADWVARPIASPEEPQPDHPLRPVRFRKEFQVPAAGTIEKARLYITSFGVYRAFINGHRVGDQCLAPGWTSYRHRLNYQVFDIAPLLNAEGPSVLAVEVAEGWYATRLGFLGGRRQLYGDRLAVLAQLEIQLGPKGDRFSMCTDSTWTCTPSAIIRSEIYDGEVYDAREENPTWNCSLLDQASRWVAVRELDFPTAALVAPNAPPVRITEEISPVSVHKTPSGATVIDFGQNLVGRLRVRSLNKPSGSRVSFIHAEVLENGELGVRPLRHAKCTDEVILNGTELVDWSPQYTFHGFRFIQVNGWDEESDGSLLLNIKALVMHTDMTRSGWFSCSHPMVNQLHTNAWWSMRGNFLSIPTDCPQRDERLGWTGDIQIFCPSANFLYNTAGMLSDWLQDVAAEQLREKDGCVPPFTVPNIISETLWPHTPQAVWDDVVILTPWALYRSYGDSDILRRQYESMLAWIDRGIRRGSDGLWDPELWQLGDWLDPTAPPEEPGDARTSGTLVADAYLVHITSVMSEISQVLGQSQDAARFKTDYNRLKAMFQAKYITATGLLVGDTQTALSLAIVYDLHSTPEAAQAAASRLVHLVRFAKFRVATGFAGTPIITHALTKSGHPQIAYRMLLEKSRPSWMYPITMGATTMWERWDSMLPDGSINPGEMTSFNHYALGSIINWLHSTVAGVSPLAPGWKHIQVAPTPGPAIHSAEAMYDTPYGRLECRWSIETDADRFHMDLLIPPNSRARVILPTREKLSQPVGSREDGGFWVGSGRHKFSAIFEWKDYTRDWPPKPLIPIMREPEPEDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R336</accession>
    <name>A0A8G1R336_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Swi5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_489051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514802.1">
        <property type="nucleotide sequence ID" value="XM_025663576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R336"/>
    <dbReference type="GeneID" id="37166978"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032798">
        <property type="term" value="C:Swi5-Sfr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034974">
        <property type="term" value="C:Swi5-Swi2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010772">
        <property type="term" value="P:meiotic DNA recombinase assembly involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000056">
        <property type="entry name" value="DNA repair protein SWI5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH56880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="109" mass="12213" checksum="1594C61937C2E01A" modified="2022-01-19" version="1">MPPPQQATSSTTTPASDEQIQTQKDKKLSTLRASIASLHSQITETESQIEQTKAKLKNDPSTTVKRHIRLLHEYNEIKDIAQGLMGLIADARGVRQVDVQREYGLDDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3H5</accession>
    <name>A0A8G1R3H5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_478255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514997.1">
        <property type="nucleotide sequence ID" value="XM_025662891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3H5"/>
    <dbReference type="GeneID" id="37166293"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="261" mass="29975" checksum="3BFDBBEDEFBF1240" modified="2022-01-19" version="1">MPDPDSVSNNSSLLFSSDDEHSSGHYDADDFRGEDDDYFQQCHICGYAFYLKRYAPDEHDLNHVTFHHPKKGICKAQKVENLDLYGDDQSWWGMPRRMILHNIINDGCQISGVTIPRTNYGTFFVPWKKTDGLIYEPRTSEERRKAVMPMITVVNDGGHPLMSGYEDDISHGWMGYPVHARCWELLMHHKLGDIANKNLKVLMLALIQRHEENSWRRTRSGLTNKKQRQDFSTEGCSEGPRVYASASPMGNIEYGVRLSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3J2</accession>
    <name>A0A8G1R3J2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_478055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515521.1">
        <property type="nucleotide sequence ID" value="XM_025662869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3J2"/>
    <dbReference type="GeneID" id="37166271"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="206" mass="23224" checksum="62DCDCF242F831EA" modified="2022-01-19" version="1">MNPPNLLPHDPHHHHHHHHHHQPPTLTTYLTHLPFLPLHDRITSLHHLSQSLTPQITPTGTRLINHPSFTGPAPLDHLGTIYITTGRDCVANNADLTIRILHADVGALLESIYEKSGELLDAGIQNGSVVLSEENKLRDGAGACCRGEPEVMFREGWAVEEALWFYRVDFESRWEVADRDGERVLFRASVGMLERAAEWEEDEEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3M3</accession>
    <name>A0A8G1R3M3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exocyst complex component Sec3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_370057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516575.1">
        <property type="nucleotide sequence ID" value="XM_025655949.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37159351"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13315">
        <property type="entry name" value="PH_Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.90:FF:000003">
        <property type="entry name" value="Exocyst complex component Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="95"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="626"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH58653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1509" mass="167364" checksum="E0F29F4DADE5C01B" modified="2022-01-19" version="1">MSSRDRMRGPPPGEMPPQRDPRRAGDSRNGGNAGPGDASMSRAEKFEDEKRRIIHSCFGKKDSDGSLVESYITHVRILEDAAYPSTPAPPNSPPENKKPRVIIVAVRRSGRVRMHKARENNDGSFSIGKTWMLDDLSSIQSYNALVPSTPLEQQHKQWAANVGFIVTVGKPYYWHARTSKEKDFFIGSLVKIYRKYTGGKVPTLIGFDERERQLLAGASAAGPPAPKGPPPGPPRPEVTLPPPRPPSSQGSRPQSPYSSRAPSRDGPRRPPPPPSEEHALRGQRSRDQMGRPSTGQSGKSGTPPFSPPQHAPPMPPDQREQPPPRAAERLAADSRVPKVPIISPPEPRNRDYPSSLQAAPVAGQRERSNGNFEDARSGSPLPDSRPPSSRDGRRGPESRPTLRTQDLHPSRSTDGLRPTTPGSVSGEKLTFMHSPGSSVGPRSPLREAAEKPIGSPARAERQEPEPPSNPINTPAVEVPAALTPGSSGFSKPPPAVESAEAPVPTAPTLPVLTKDPEPIQPIAETAAAAVPPPPSDLEATEPVEENDPDAHRPGLGPMIKKKQTKDVASAFRKAATAHGAFKPRPGGAGERLLAAAKKQKAAADEPDGITSVVPAPFLLRTNSENTVTSPATPEAETPPVVSSSPEKEVQPPAPLAPPAAPAVQPPAEPPRMEPPAVEVTQPAPEEPTVGSTEVLAEPRDTSRASVKVDTERSRSVSPSPHDRRRRRHEDNTIKYCQALGLNPSVLEGRGIDFDDILTDLGWNGRLGDEKKIEDLEADIRREIGRVEATSWLGNLEQQEGKIDQLAKLIDKTIVECEELDNLLTLYSHELNTLNDDVAYIETQSQGLQVQTANQKLLQNELQNLLKTLSISSDDVRALKESSLSNPDGLRDTELALSTLYKAMLMIDSDIWHNKRRLADAAGDHGSLGVYADTEIGQMRAIKEKKEEYRTHARVFLQRLKQFMAIAYKVAEQKRIDAAANGQKDPLKLDSEARGFCRRELWQYHAVILFAREVSSGEWHALINLYEQQAKHPYQNDFRDNNLAWKKAARKPSGEEQELLFTHQEKEKESEGITMAARKLTVRRGKTIRAAAGLRLPSGEKQHGKLEPFEAFGGTLQETLHMISEEQNFIVYFFHLNSLSTVDFPDLVMSGAPDERRIPSFGSKQLHDPDRAMAKKVEQIMDELFAFWPTDMQNLVDWAIRADPLQGIGILLAIEKAISEFDDTNQDFIIHSLQKLHSRLLGLFNRFVDEQIRGIEETKVKVNKRKGVISFMRVFPHFSTAVENMLSQEFYDIRVNVNEAYDRINRAMWESLKFIAKEAPGQPTGAAATSGDPEDKEILNYHILLIENMNHYIEEVDVRSLPVLERWRDRAHQDMQEHMKLYLDSIIHRPLGKLLEFIESVENLVATGINPADIASRPSHSRSVAKKVLATYDAKEIRRGIEMLKKRVEKHFGDADDPGLSRSLVLKVLRECEGRYGKAYDRTRRVVDAVYEGQLELEWRKEDAIAMFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3M9</accession>
    <name>A0A8G1R3M9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_375187</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514182.1">
        <property type="nucleotide sequence ID" value="XM_025656159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3M9"/>
    <dbReference type="GeneID" id="37159561"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000050">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="84"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="556"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="636"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="481"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="191"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="659" mass="74169" checksum="57E4898D43D15AB1" modified="2022-01-19" version="1">MSLDPRFYHHIGHGSGPGSQSSASSSGISAITGITSPSAHSMTASAATLRSTASSPSLRAREGVAVSAHHRVDSMSSPSSGGGNVRVVVRVRKFLPREINRNAECLISMDPHTQTTKLRAPQISPEDEGKPKSQARGKVLEDKSFVFDNSFWSHNERDPHYAHQEDVYNCLGEEFLDHNFEGYHTCIFAYGQTGSGKSYTMMGTPEAPGLIPRTCEDLFQRIESAESPDISFNVRVSYFEVYNEHVRDLLVPRSDPPHYLRVRESPLEGPYVKDLTEVTVKSFDELMKFMRKGDVSRTVASTKMNDTSSRSHAVFTITLKQIHHDLSTDETTERTARIRLVDLAGSERAKSTEATGQRLREGSNINKSLTTLGRVIAALADPKPGRGGKRKGKDVVPYRDSILTWLLKDSLGGNSKTAMIACISPSDYEETLSTLRYADQAKRIRTRARVNQDHLSAAERDKQIAEMAETIRTLQLSVSLAAANRRENEMQNERLEDYQQKVEKLQRLMEETKMVSECKIRQLQTENEALRNHLKLALDSIRNPIPPVVVHKRRSGLYSVNENDGSPSNRKRLSRARSPPSDVEPEPEPDLIWEDEDTMQSEASHVEAQEVQTHMENLLDDLSMFKRKIATDHERFRPSWKPEGRKRRRALGNVWVNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4A2</accession>
    <name>A0A8G1R4A2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras small monomeric GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_371674</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516149.1">
        <property type="nucleotide sequence ID" value="XM_025656007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4A2"/>
    <dbReference type="GeneID" id="37159409"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001856">
        <property type="entry name" value="RAS small monomeric GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH58227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="291" mass="32006" checksum="DA2032AE4D5BF253" modified="2022-01-19" version="1">MADATDKISITICGDGGCGKSSITLRLVRSQWIHEYDPTIEDSYSVTRVVDGVPYFLSITDTAGQEEYRGLWAASNLRSDAFLLVYDITNKSSLGALDYFMDMIEIETEQRLEDNDRLRKELGASAEGLDVGMPPPVKIVAGNKCDLKDNRVISSREGLEYARKHGCGFMETSAREMVNIEETFALLVRRVVEARRLHYQKGPPTSQTAQKGEPSTAAKAPADTVVSKEGKGESQKRTQKRQSGLRGLFGGKRARQDPGEKGHLQPEASGSGQNKPSKPAKASIWKRMSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4L5</accession>
    <name>A0A8G1R4L5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-1,3-glucanase/mutanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_369214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517301.1">
        <property type="nucleotide sequence ID" value="XM_025655908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4L5"/>
    <dbReference type="GeneID" id="37159310"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF33">
        <property type="entry name" value="ASCUS WALL ENDO-1,3-ALPHA-GLUCANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="63759" checksum="5570A0B04FD29570" modified="2022-01-19" version="1" fragment="single">MIIKVTNTQNFTTYDWEINMVFAQQAHIDAFALNMAYGDPTNEPSLVNAFEAASVVGFQLFFSFDYAGNGAWPKSTVIDLLTKYGSNSHYYQYKGKPFVSTFEGPQSASDWIDIKEQTGCYFVPDWSSLGAKAALEASPGAPDGLFSWAGWPWGPNDMDTYVDASYMQYLDGKPYMMPVSPWFYTNLPGYKKNWLWNGDRLWFDRWQEVMYLKPEWVEIISWNDYGESHYIGPLHENAYAAFDIGEATYNYAAGYLHDDWRSFLPYLISLYKTGTATITKEGVQVWFRRAPAAACTNGGTSGNTVSQFQIEFPPTEILKDRVFYSALLGSPADVSVSIGGVVQQGSWSDAPDGGIGIYHGSVPFNGNTGQVVVTISRNGAVIASMEGESIDTSICLGGIQNWNPWVGTIFADTTISATPELRISEQVCVNGTGPNKFARLCGFSCSYGYCPVGACVCTAMGEQRPLPKPTGVKGYPLAGEDASYSGLCDFNCNYGDCDPEACGTTEVELTVPTVSDFSPPACVSGTGEGNLAGLCSFSCTYGFCPINACTCTGEGALVLPPPTQNVSGYAGTGLDASVYGPLCEFTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5Q4</accession>
    <name>A0A8G1R5Q4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_478430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515202.1">
        <property type="nucleotide sequence ID" value="XM_025662899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5Q4"/>
    <dbReference type="GeneID" id="37166301"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="606"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="643"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="695"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH57280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="746" mass="81319" checksum="581942ABA1D3EF37" modified="2022-01-19" version="1">MEVANFDMLFSKSGRTIFPLLPPYGVQDPNGVQGRVIPVHPDGSTPYLGLRARLSQVWLNRWTVLLLLVLARVLMAASSIKTDMNRAKSEALSACTSVESMGDAMVSMPHYLAGGVNELTADGVNAAVDGLKTLLMLTLTGVEELVIFFVKVMYQTYLCLFTLVVHGVVDVGLSLIEDVTDVLNSTVKTVAKDIAKVTETFEDDYNKVISKINGVASLFGGSVPTLNITSEIDKLENVQLPSSIDKDLQKINDSIPNFNEVMNFTENVIRFPFDEVKKLVNESLGNYTFNASALPVPAKKTLTFCDKNDGINSFFAGATDIILTARKIFIAVLVVAAIIACVPMAWQEIRRWHTMKERSQLVRKEAHDPMDVVYIVSRPHTAAMGIKAASRFSNSRRQILVRWVIAYATSPAALFVLLLALAGLLSCLFQYILLSAVKRTVPELSNEVGDFAEEVVSVLQNTSAQWANDANKVIINVDDELNDHVFGWVNTSTGALNDTLNTFVNKTIGVLNDTFGGTLLYEPLLDVFDCLIGLKVESVQKGLTWVSDHAHIDFPLLPNDTFSRGAADSLNSSDASDSFLADAGDETSNKITEVVYKVISALEKALLIEVIIASCILLVWVINAMFGILRALTLFWGRDKNRGEGGPAPPHSRPNPGSGPDTNGFTDVPLTTLPSHRDSEETAARSQPAPRYEVATSQGSSAAVVSSDSEYPDEKIGFAGQRNALRVDGVSDLRGSSYVEYGMEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5R7</accession>
    <name>A0A8G1R5R7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="6">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_520093</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="6"/>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516152.1">
        <property type="nucleotide sequence ID" value="XM_025665098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5R7"/>
    <dbReference type="GeneID" id="37168500"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.20:FF:000003">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000030">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase, carboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="8">
        <location>
            <begin position="39"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="7">
        <location>
            <begin position="115"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH58230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="314" mass="33537" checksum="90DD4F3663E7FBA9" modified="2022-01-19" version="1">MASQYGDLRHLLPGNYKRLIADWLEEDCPSFDYGGFVVGESEGEARLLGKSEGILAGVPFFDEVFSQLGCSVTWHITETTPIKPITHCATVTGPIRKILLGERVALNILARCSGIATKTSTLVSILRSHSWPGTLAGTRKTTPGFRVVEKYGILVGGADPHRHDLSAMTMLKDNHVWACANNSAAKDGGDKEAVEEGSIVRAIPRAVQAAKAAGGFATKVEVECRSLEEADAAIKAGADVIMLDNFTPEGVRDAARKLKTTWAGKGKAFLVEVSGGLNEQNAARYACPDVDILSTSSIHQGTGIVDFSLKVSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5T0</accession>
    <name>A0A8G1R5T0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PHD and RING finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_468794</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516167.1">
        <property type="nucleotide sequence ID" value="XM_025662292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5T0"/>
    <dbReference type="GeneID" id="37165694"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15545">
        <property type="entry name" value="PHD_BAZ2A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047157">
        <property type="entry name" value="PHRF1/Atg35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618:SF20">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="134"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="626" mass="68921" checksum="6BA8BC2664D25660" modified="2022-01-19" version="1">MSDTCIVCLGDLGESASDPLAVAAEAAPRLDLGAEGKSADTSLNNHDGVDGTEDSGQIAQLLPCGHILHNNCLKPWVERANSCPICRRSFNMVELSDRPGGPVTSSYAVQDRVQQAEVDPSMIIEYIDDDFADFQPCPICGDADNEELLLLCDGCDVPSHTYCVGLDSVPTGPWYCTRCVTQRRLGRSPETADWSSQTQDRRGRRTRAQRRRLQSRNQLNSLHWARVWQSVWDHLNIDLDFPFDDDMAAERARQEQRREEAHQRDFRAWQRRFEVAEQQGGGNRFRDTAALLDIEAPRPSRPRVPREPTPEPESLEEMRAWNAFERAREIENDPSAARKRKEPTLSPSPEPTEPERKLKRPRTRRAEDLAARAVQNGESSRAASAQASARINAESSSEPSFLQSLLKEVEESSNPNGVTSHGASGQSSIAPTDHATPGPSSPSISPAPSNHSSPRLSSVTPPPTLRSRPMSPLQLGSPADPSSPPFSPDVSPVGSARSAQDDHSSQAPTRRPNRRIPRSATRSAAIRSDDSSPSRPGLSLKVKSDIQKLVGSSLKPYYRSKTITKEQYTEINRNISRKLYERAGDVETLGIGAKATLATVAKDEVEKAVDALKQRHDLNDSVDESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5X6</accession>
    <name>A0A8G1R5X6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_369993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516751.1">
        <property type="nucleotide sequence ID" value="XM_025655947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5X6"/>
    <dbReference type="GeneID" id="37159349"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="304" mass="34836" checksum="4C6624836DD3D730" modified="2022-01-19" version="1">MQEMFPSWSWSSVDNEIRLCPRNGQWERISVSLAQFAIPSAQNRQTQWKVLQSTSTEPHKLDSRHFKDHILACLAVLIAWKGGCFPGKLPEALDAKVTWEEYVSIIRRKWTSLAQMGDEAYCMQEGLLSVSDQEARFPLKAQHACRDGCILVYTQSLRLRMKGPEDSMGYVKLLDRGGNMVGWLEPTSINWGRLRQIPDWNNGAKFDVLALSLQYEAKYTYSYSATHPARSYGRDVANWRDSNQKTIFIDDHIDRISPYDVHLVTVNLMVVESENGIRKRVALAEAALKIWIQAKPQFHTFILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5Z6</accession>
    <name>A0A8G1R5Z6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_486878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517203.1">
        <property type="nucleotide sequence ID" value="XM_025663415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5Z6"/>
    <dbReference type="GeneID" id="37166817"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="172" mass="19539" checksum="CD0D4EC8A6A9E74F" modified="2022-01-19" version="1">MTDIQARPSSPPTPLVTLSDLKESSISPTFWYRVHVLVFDLKNFNNASSKKRLDKVTDPSYIDKPYFSPEEAEKIKNIVTDTSGKTFSETLEEGLNERLERRKKKRVQSGDFRVCAAHDLAPLIASALGIDLKQMEKDKDFAKVVEEKGLNLRGEIWGGLKKKSFAPKNKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6K7</accession>
    <name>A0A8G1R6K7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aromatic aminotransferase Aro8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_510163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517364.1">
        <property type="nucleotide sequence ID" value="XM_025664536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6K7"/>
    <dbReference type="GeneID" id="37167938"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="85"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH59442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="505" mass="56790" checksum="C6D2FC7BE6E62B53" modified="2022-01-19" version="1">MTQSQSTNELPTAVDFSHHINLRSRARHPSPLKDIIRFMAVEDMVSLAGGLPHPSFFPFHRVTITASTPTAENSTCSLELPLEGFLQYGSGSGNAQLRAWCREFTQLVHSPAYADWEVLLHSGNTNAWSKVVGLLCEPDDYILCESYTYPSAQAFWIPLGNKAAPVPSDAEGMCADALAQTLRDWDDTHPGARQPRVLYLVSVGSNPSGVTMSIQRRRDIYDVCVEYDVIIVEDDPYFFLQYPECNASQVTMDDPELVGSDEFLRSLTPSMLQIDHQGRVIRLESFSKTLAPGLRLGYFVANPVFTERLLRATEVETQDPSGLSQALTLRLMQSWGIDGYLGWLQGLSVEYRCRRDWMIDAFSQHFRLEDAAEDSRALVAHLGDIPIFSFVPPTGGMFIWACFYLSQNSAFKQLRHDENVVDPEQTVADQLWRQLAEAKVLLTPGSYYHPWEGPDKITTHARGATPSTTNFRFSFSMTTKEEMERGIARMARVIRASWKLDQLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6W1</accession>
    <name>A0A8G1R6W1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_466924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518315.1">
        <property type="nucleotide sequence ID" value="XM_025662155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6W1"/>
    <dbReference type="GeneID" id="37165557"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056021">
        <property type="entry name" value="DUF7600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24539">
        <property type="entry name" value="DUF7600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="222"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1090" mass="121385" checksum="9D8BB857807E8B3C" modified="2022-01-19" version="1">MVSNVYCPFCGVILLPDPYWDGPDTPQSSTRPWYAQVRGIYSTNPAVDHIKITGVGVVRGRKTLHAPLDSNRVYGEVASVALDEWRLCEQSDSQWCFGFHESCWKLLILSLNHGRVRSLSQTDAAIVEMVFYQLYCTPCLEASIFHFGHDYAGAAQTHKRFGRIQPVDLNSHLYADPCAFSVMNYPTDSSSASEESGSSPGRILSHDNSTVGSLAEVGERRHHAFRNLSTELLLEIFSYIPFEQHLTLRLVCHDLAVLADMSMLSQSYWRSRCLLGQEADFVFPCLSESQNWFRLFFATRASLKAATPPLVNRKRIRDLLEPIASLVDLDSIFRRGPGGLDYCPSPMQGNNFTLVDIESFQAGPRLAKVVGYFSGQLAYIDEDCPLQEGCRVLYRKAQPFMVPQEEHEKRIGISTVKIGARRFISGINILPSNEGNCVGRLIGYRNPAAETYIDVPTNLFIKDFRVAFCAEGLVGIQLQYDNSASSRWIGDSNGPGIARGTLQIPTRADQYHLLADIDRFKIVSLGLAERIDDHQSSLHRTRSDVKEPFHTPSQLWVPHAPMHEGLLVSLLLPSEPPRAFEPLSNIDFGGPGGRSLMSLIRLDFHMTSYPHPLIGIGYHYADGKSVFFGSTGGCAISIPINGPSGERISGISIVEDNRDFYQSEALGGLQVSTNYERSFILAPLSYRLEASVTPIPSLPPGRFVTGLVAHQKTYGTHFIRVGIQSQFCDEPSTIPHILDRECHLLPDNEIRYDEKFSHLINGSNSGNYQNYASLKGIRKIQASAGISGWSRPQNGISGLKLEYYNHPSPAIVGQWMNELEDCFDISPDEDIQAVTSPGLAVGQVAAIRFETTCARSVTFRSPHFRTFPTGIIRNEYQRCFDEELTAISWIFNESSDRVRAVNSPHRSWRPRLLVPEVSPPFDLVRKLYFETRNDNTCPERVVTIEAYFRGRAIIGLLFVYSSGVMASTGDLDTDSRQAVHIASDDKIAGMSATVAGSELVEIDFEVEHNASPKCQRLSLALEPPYTPETAMDYGWRDVWCKDKAAVECTTRQGGSDRVYAAPSNSILMGIYIGCQRFSSVGAIYEPDISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R720</accession>
    <name>A0A8G1R720_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acid protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_476644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516812.1">
        <property type="nucleotide sequence ID" value="XM_025662794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R720"/>
    <dbReference type="GeneID" id="37166196"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034484104" description="Acid protease" evidence="1">
        <location>
            <begin position="28"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="43276" checksum="AE7CAECA9B498AEF" modified="2022-01-19" version="1">MASRSFSSQSLLTGFLLTLISSPFASADLTLVSNPQTTSAPVETVSLIDASGIPITTANDPADNAWVIPLTGPASAPTGAAWGAQIQYNNDLAGVLPVAFGTPTTTAKPTATATGKATSKTTATFVSAGSPGQKTETLDLEIAFSNTLLLSQDTSLNITSTTNKTNSTTIPSLPVGLNLGLRNKWNGSVVLGGNYDSNRIYDEPHWQTTPETSAGNTSFIDTGMLDISAVILQLYTTPNATTSSEDAEYPFGGTSVQETSKSLPAMLDFNSEVLSVPDESWCARNISIVFNPDSESYPIFDIPVWDELVPKERCQVSSGKVVLGRPFFQAAYVYVNSAGDMYFSSITTDDVAVATKPFDLHVQLSEAVNGTESYGGENGTATGSGSDATGTSGAGRLGVEGLLGVVVGLGLLFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R754</accession>
    <name>A0A8G1R754_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenol hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_446499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519268.1">
        <property type="nucleotide sequence ID" value="XM_025659517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R754"/>
    <dbReference type="GeneID" id="37162919"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="451"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="646" mass="73085" checksum="C8CBE74C29EAE84F" modified="2022-01-19" version="1">MTVSTESTTDVLIIGAGPSGLAVAYWMAQYGINARIIDKRSTKIFRGHADGLRGRTLELLDSMGITQRILQEGYHAAGLKYWRPDGKGGLKRAGQLRSTIWKSSPHRMALLSQGRIERFFLDVIRDSSSIDVERGVMGESLTYDESLENDTQAYPITIKLRTLSEEEATPIPNPGITPYHPARDDLEDLAPKRKHEVGTVETVRAKYLIGCDGAHSWTRKQLNIPFEGSHTDHIWGVMDVVPITDFPDIRWPSSIDSPHGHLLVITRENNVVRFYVPLQEEDEITPSFDRSAVTLDMLRERVKSIMSPFSFDFKICHWWAAYQVGRRLAPAVNKGRMYLVGDAVHTHSPKIGLGMNMSIQDGFNLGWKLALVVKEMAPPSILGTYKSERHQLAKMLLEFDQKWAAFFLKQKKKQDQLELEGLPEANPEDIQAMQDVFRENEMFAEGHVSFYKASLIVDKDSTPVAKHLTAGERFPQALICKQADGQPWWTSRLLNSDGRFRVLLLVGDCRLEDQKSRILALDGGLSALQKRFTPPKQKLDSVIEVKAIHSAPLDDVELSDFPPVLHQFDETTGWDYTKVWSDSECFWDEQCKGNAYEIWGVDRSRGAMVALRPDQYIGWIGELDDVAGVTKYFEGFLREPRPEAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R795</accession>
    <name>A0A8G1R795_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_446024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518790.1">
        <property type="nucleotide sequence ID" value="XM_025659402.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
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            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
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            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
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        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="607" mass="67490" checksum="C2E641A420899247" modified="2022-01-19" version="1" fragment="single">MEAWLKLQLSTKSSQHEARKLPTRDVNATSETPADPRHCTQPLGNTHKDHNDEKQVEVNDTSSEEQSPADKVVESRQSWADTATCSPQLEIDFSAFDEPNNATEELYDPLFDSELVLQEIDAVLQRKRNGDEAFPEDCVSWDQSRKRQATEISQYSTTESPDKTPSLLSLDSGQPEQGGTGPHTPSDVEKRQSDAVFDSIDLLFEDPSGDFPLDIPDGEVSFNFDIQGSGNGEGSKEDMSANFSVFDQSFNLPSVSEITKERFSLDHQDIVNSTNREVLQRVFAEPEYVSPYPVYGGPLGYMPSAPNIHVRCIEVSDDRTNLRLATLRNKVQQLTLERNKYKQEWALASDLTALDPATGKTKQQTLLEQNAMLRRVCSRHQQRVEQYKQEAIEWKNKLHDLGTIYNNLLYEIQVQKQMPVVAPIPTGYKPPRARQASSNATSVQPSTSQSQSMASTPNASAGEPITIDLTEETGDDGSAVANPTPEEQEERQRRVEMLQSLRNKKYSWLGDADGDVGNQNFRISVTPAPRQGSLKPAGGPHDSERSRDNHVPARGPCEIASDDRVEEDDDELARMMEQELASPIATSKPGDCDVLKAQVGDSLKIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R805</accession>
    <name>A0A8G1R805_9EURO</name>
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        <submittedName>
            <fullName evidence="4">Arylsulfatase A</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">BO85DRAFT_446751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF6">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="327"/>
            <end position="489"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH60192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="500" mass="57612" checksum="7DF2EF5220A5B4B8" modified="2022-01-19" version="1">MADDHASKAISAYNTNINHTPNIDRLYHDGMKFNHCYVTNSICTPSRATILTGTHNHVNGVMTLDSKINKHLPNVAKHLRTGGYQTAMIGKWHLGEGEDHEPTGFDYWSVVPGQGRYFDPEFIEIGGEKVVEPGYATDIITDKCLGWLKNRSSGVGEKKPFFLMCHHKAPHRSWECHPAHRGLYQEDVVMPDTFDDDYKNRAKAAEVAKMRIESDITYFDLGLVQPEGGAEVGELFGSRSTDRKIPNVSDADIEGFRLIDKDTAEVFTFKSNEELRRFKYQRYLKRYLRTIHSIDENVGRLLDYLDEEGLAENTVVIYTSDQGFFLGEHGWFDKRFMYEESFQMPFLIRYPKLIKPGSVCDDIISNVDFAATWLDLAGLRIPSYMQGVSFAPLLKGETPTDWKQVAYHRYWMHRDPIHNAYAHYGVRNQRYKLIYWYAEDFDLPGTQEGGQPKEWELFDCEKDPLELFNVYHDAKYADVVVELTRLLDETMLEIGDTPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R894</accession>
    <name>A0A8G1R894_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like protein smt3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_184928</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R894"/>
    <dbReference type="GeneID" id="37157780"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="23132" checksum="C9206179028F33FD" modified="2022-01-19" version="1">MSVPATPPATTPPTASASATSELQSSLRELSLANKSPIKDIPRPTPPTSVPKQHHHTVKKKKEPAPVADSWEDEVDSASASDPEGGAADISSTSPATSSRFASPALSPSIRYTEGPLDPPPTPISPQTSASQPPWPTYGGRSEARSPARRPEKQTAVAGRMIAGALGIRAPKRTEEQRAYDRAVKEQEIKRRNKEKEEAAKAKEEEEKAKAAVWDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8Q5</accession>
    <name>A0A8G1R8Q5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_235240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518598.1">
        <property type="nucleotide sequence ID" value="XM_025654802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8Q5"/>
    <dbReference type="GeneID" id="37158204"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH60676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="173" mass="19621" checksum="91C5175B8C540749" modified="2022-01-19" version="1">MCTGLTQYVLLYLRTSFPNFSRISYHSNTESAAFRERSSLSKPIVNLSLAIGLHVVATRSTLPYTGSSDIFQCWRHSRCLPRRQKYTPATRDAKRSRLTEHCSSRYIIGLSSKACAIPQVHACRLPFKQWRWINVCAHIKRSMLLVAAESTKASCAITQSSRYRCLTGCSRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8V7</accession>
    <name>A0A8G1R8V7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_467627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH60000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517922.1">
        <property type="nucleotide sequence ID" value="XM_025662199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8V7"/>
    <dbReference type="GeneID" id="37165601"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="50"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="620" mass="70745" checksum="9185873302B25357" modified="2022-01-19" version="1">MQALYNRRYNYSRLTEEGEIRLLKIYPKTDGDGEICCDVFNICLKDHPSYIALSYTWGAPTPEAFVKGATSVPDRHVKCNGDFIYITKNLHDFFTRVRDVRKLYTRSFWVDAVCINQEDELERASQVGFMASIYRSADMVISWLGEQDAHTKDAFWLIRAIGIATVSEDATTNNTASEDSVDVCGRFLEAPEWISLEEFWKRTYFTRAWVIQEIALAKRVIIMCGGHTVDWDHIVQVSRYLTLPPWKWVSYMKSSIRKDGREASHSLPLYLNSNRKMVLSEKRSSLLHILIKSRRFHCLDPRDKVYALLGLLGGRTQGETRLKPVYKDRPVSNVYISTAIYVLEDTEDLLLLAHAEGKDFRNIKDLPSWVPDWYLRIHEAERYLIVRGVWLDRVAQVGESKDEATNHKGLAYFPGWIAILLALPLKYHTGQPKAEVFWRTLITDTAARIPQPAHHPAPDEFGCAFSDWILRIVSEWTDKPLSAEKTDFLDQLYQLGDSDETGLFPYAAGEQGNGPRKISNICPAHTGTSDVPNGDAYEVHLNYSSQTRLLRTDSNYLGLATTSIRERDSIWIIAGSRVPLVLREADQRDAYQVIGGAYIHGFMQGEALKLGSEFTLIKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R955</accession>
    <name>A0A8G1R955_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FHA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_500855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519500.1">
        <property type="nucleotide sequence ID" value="XM_025664138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R955"/>
    <dbReference type="GeneID" id="37167540"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="33"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="700" mass="75816" checksum="6670C6AD279529FC" modified="2022-01-19" version="1">MPATQAIVTLRPLSVSDDLPYRSLEFTSTNNQINIGRASKRESKNLIPARNNGLFESRVMSRNHAKLWVCFDKQLVYIRDGGSMHGTWINGKRIPREEDSVIKHDDVVTFGSTVYRGSDTFPPLKVRCEFEWPDPLYAPCVPPSLSSADTMDSQRTALATNTFCVPDDDDSDAKEDSVPMVVASDSASDIDNSTPDSDSDGQSVMEVSSPLTSPLKRDDARNSHVGACSDTDQVGRHDGQQGSQLSPIDLEHGQHEQPLVTPRMTPPSVIDLIDDPSNAAHDFDDFIQEADSASAMNTSDDEDSSWGEDYHAGSDDDEDDEVDSQSSFRSNAEHSHEDEESVRSSSLHVLGIRDLIASEASYAVEETNARLPTGNDTSKPEFNDRHGEDMAYDAETCEPELLAVRNSTSDLRSQSTGPSRIISTEAPPPPILLQPTLSSPYGKTVDRSLPSYQNNPPMMHMDWWNPRTTANTSYSLHIPPTPQVPYADGPFVNNESFLLGETDPACNRGSDSVVASMATPGIVSQEAPSSDGQEIQETPMPQKQPDPIPTPLPQMQRSEIGLDSVPANKPLKRKAEDIDGSSGSSELDVATHHRDGVDSAVTSDSQSSDQETCYPDAQPQMPTDQQELPSQLADLDSAKELPSVDDSINDAETTAPPTKRAKTSSTGRFASHAASAALGVAIGAFGTIAALASLPPDYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAG9</accession>
    <name>A0A8G1RAG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_482907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520978.1">
        <property type="nucleotide sequence ID" value="XM_025663128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAG9"/>
    <dbReference type="GeneID" id="37166530"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="CHCR" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="166" mass="18998" checksum="16CF38689C50CC88" modified="2022-01-19" version="1">MELQDLVRQYERNGYFDELIAVLEAGQGLERAHMGMFTELGIALSKYHPIILGMLMRDQKSLRCSITRSGWYLERAMPNSVNMPKMIRACENASLWPELVFLYCHYDEWDNAALAMMERAADAWEHHSFKDLGLVSDGLEAVGIRGIQNDDSFALTLFSEVAQYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAK0</accession>
    <name>A0A8G1RAK0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_110290</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519513.1">
        <property type="nucleotide sequence ID" value="XM_025653845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAK0"/>
    <dbReference type="GeneID" id="37157247"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH61591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="164" mass="19280" checksum="ACB69F2B6C3F2BC7" modified="2022-01-19" version="1">MAIHYLILLSRQGKVRLAKWFTTLSPKEKAKIIKDVTQLVLSRRTRMCNFLEYKDTKVVYRRYASLFFIAGCASTDNELITLEVVHRYVEQMDKYYGNVCELDIIFNFQKAYFILDELLLAGEMQESSKKNVLRCISQQDSLEDMEVSRERLLLHNTQHPLFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAR1</accession>
    <name>A0A8G1RAR1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_501147</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519618.1">
        <property type="nucleotide sequence ID" value="XM_025664160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAR1"/>
    <dbReference type="GeneID" id="37167562"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="395" mass="45163" checksum="415BD69D4D7AA74D" modified="2022-01-19" version="1">MPPRRAHTKSRNGCDQCKSRRVKCDEAQPCANCVKRNLTCTFERRPPKPEPYPSTQSGKLSESPTVSSRTDDAIAAFQHQVADASAFLREWGAQDPELMHHYCIYASKTLSDREVIRDVWQIEVPKIAYSYEFLMHGILSLSALHLAYTRPERYSHYLNSSNFHMALGLQTFRIILQNPTKQNCEALFCFSSLIMVWTCGAPTDLGDSRPLESIIRLFNLCRGIMTLQPFMSHVENGPLAPLFLRDFRSDPGPLEDHVQSLRFPGLGDQLDAIRQLIATEPLSEQERLIYQQATECLEKAFWRLQVCEKPAQCGIIYMWPISVRDEFVGFLLDRSPIGLILLAQYCAQLYLFRGYWFVEDRAHELLSAVAAALPSRLAHWLDWPRQFCSSGTLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBD2</accession>
    <name>A0A8G1RBD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_412163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519541.1">
        <property type="nucleotide sequence ID" value="XM_025657553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBD2"/>
    <dbReference type="GeneID" id="37160955"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF64">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034484027" evidence="6">
        <location>
            <begin position="19"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="570" mass="62765" checksum="C7AECF6E72737FCC" modified="2022-01-19" version="1">MYTLWAAALVAALPVSRAQFVSPPTDLIPTKGYLDIPVRYKQVSTGICETDPSVKSFSGYLDVAEHEHIFFWFFEARNQDPTEAPLTVWINGGMSHPGPGSSSMIGLFQEHGPCGIDANGSVYNNPYSWNNASNMLYIDQPVQTGFSYSIPVPGYVDSSTDNVIALPSPVCPDYAADMSCGTYAYPNVSLTANSTDNAAPNFYRALQGFMGAFPQYSRETFHFTTESYGGHYGPVFNEYIEEQNAHLQPGAKKIQLGSVMIGNGWYDPIIQYQAYYNFTVYPGNTYDYLPFNKSISSLMYNNLYGPGNCLDQLYDCAARGIDEVCSTADSFCANEVEEIYDIYSGRDEYDFRELTPDPFPYEFYVDYLNKASVQAAIGAYINFTESNNAVGLAFSSTGDDGRLMNTIQDVGKLLKQGVTVVMYAGDADFNCNWLGGEAVSLQVKAANFSSAGYTNIVTSDGVTHGQVRQAGQFAFVRVYESGHEVPFYQPLLALEMFERVIGGKDVATGKIPVTPSLQTVGTLKSTYREGNGTIQWEVLDSLATYNTTTNAPNPVSRKLKRMGPALRFQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBK9</accession>
    <name>A0A8G1RBK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_222969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518217.1">
        <property type="nucleotide sequence ID" value="XM_025654724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBK9"/>
    <dbReference type="GeneID" id="37158126"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468:SF1">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468">
        <property type="entry name" value="YALI0A15257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="356" mass="38803" checksum="DB60C15A5B0F696A" modified="2022-01-19" version="1">MALTQPSTSERTIRKIDIAQVSLSLQDRLGLAKVKYQNGRLQALGPNHNGGIQVCLGSDRPSDSSSEVSHSRSETPLTPPPLPNSSYSKELPRSSRNRHAATFDSKAMQPMLSASRKRLRSDSITDRTVKAPRVSWKSSHHLPESSPGFNRQHLNRHLPLPFMSDIPEYSSPAYPHHSEDDNDPDLPVHSFQHVSSMAGSSPPRTPPPKHARLSRNDRQLRHADGADLLLYLANSPTPAKSQQVRDFPPSTPPSQHAALPSLTPTPGGGGVFPNFGTPNQQFNFADFVNVTPSPAQPPWGGRTPGGPSKTPLANKERKRSNLDGLLPPSTDSPRNRGKGPAMVLQLGEELRPEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBW7</accession>
    <name>A0A8G1RBW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_445033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519512.1">
        <property type="nucleotide sequence ID" value="XM_025659168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBW7"/>
    <dbReference type="GeneID" id="37162570"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH61590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="53" mass="6233" checksum="CE73D07CA44A5FE8" modified="2022-01-19" version="1">MTHCFVARLKYLNTQELGDGLFGVPHRMWWSKWSMHFNFLKAYSGVKDSSPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC73</accession>
    <name>A0A8G1RC73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_233388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518532.1">
        <property type="nucleotide sequence ID" value="XM_025654792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC73"/>
    <dbReference type="GeneID" id="37158194"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034780582" evidence="1">
        <location>
            <begin position="24"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="736" mass="82021" checksum="84D2C0FF31237417" modified="2022-01-19" version="1">MRPSLALTSLSLVPYLFSNVGEARIYPKSPHPPSIDRAQVVSRFNPRRNASSTSTPMQVGNGDFAFGTDITGLQTFLPYSILSSWGWHNSSLPANSTPSGFTGLDWWTHDRLVNYDMPNPAEPEISQWLIANPHRINLGRIGLAFGGDYSNYTEEDLQNKSQKLDVYQGILQSNFTIDGHLTTITTIVDPSSDTIAVRLQSELLLLGLLGVFFDYPYGTDENKFEAPFVGDWNAVSNHTTVLHYTGNGNQARVQHTLDNTTYYTTLQWSGSHVSVSRIPNSHRYVVQPNGNHTRAFEFTTTFSPNDDFPSSSLSFNAIIARCQQWWTAYWKTGAFVDLTETANATADEIQRRVILSQYLLAVNEAGHDPPQESGLVNNGWYGKFHMEMYLWHSAHWTPWGKLPLLERSIGVYNRFLPSSMQRAADQGYSGLRWGKMSDPSGRSAPGEINALLIWQQPHVFYFAETEYQFARNAGGNMEDVLAKWDHILTESADFMASYAFWNASTSVYDLGPPMYPVSENTPPNSTRNPTFELAYWHFGLDVAITWKARRGQQAPQAWKHVKDNLAPLPTVYTVDETTGDHVLTYTLYEGIPHMWTDPDTVTDHPALTGIYGLLPQTTAINQTLVSATAAQVASDWNFTTCWGWDFPMLAMNAARLGDVDGAVQYLVHSNFQFDDVGMPVGTKAPTPYFPGSSALLLAVAMMAGGWDAATNSSQQDFAPGFPAQWNVRAEGFGQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC87</accession>
    <name>A0A8G1RC87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_465117</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521120.1">
        <property type="nucleotide sequence ID" value="XM_025662034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC87"/>
    <dbReference type="GeneID" id="37165436"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH63198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="631" mass="70444" checksum="DCE2DC0DA26AEBFC" modified="2022-01-19" version="1">MAAEGRIRKRIPKSCKRCHRRKQRCVGYPTCTGCESAKQPCLRSESVPSWHHAMSKGALVRRIEVLEAQLSAALEQIPPDEEAPAEPLSTGAKLQPHDSRAGVVSMMAMSQEGSDNLAYLGPSSGMSIAEDLGRLVQNAVWLRSIPINGSHHQPPPDCERTAASTALPSEAVDQMSEAARFKLFMVYAIGAAILQMTETYDSTPPSAFVAMALQLESVLGESQSYMNIEALMLLVLYHMRTSSATRVWYLIGLAMRICIDLGLHRESQYQKMRPYEGQMRRRLFWSVYLVERYVAWSLGRPFSVPEEDIDVHAPADLDDSCTSDELVEQALQGSVAPREPARGRKLRRFIALAQLQRIMSQIHTRVYRTDKNIATLVPETTPLLAALEEFEISLPAMAPEEDDFVHMHWNNAIRMLIQRFVGVLPRGDPLIEKCLYASGQMCQCFKRLRQRDSSGYSFLLVNSLYMAGLTICLCLFRAPQLWTVAVSNDLRACSSALFVMAERNPSLKKYRDGLEMIINRVMESVNDAAKADPMLSDSHTEDVIPTPHSESVSAQTDVTTGNSHFSAGWLDFQYPLPPMGGLTGHDPYGQGSAAGDTPDIWHTFSEMFPEIWSNDLLSMDMSDGLNWFTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC88</accession>
    <name>A0A8G1RC88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_360946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521460.1">
        <property type="nucleotide sequence ID" value="XM_025655571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC88"/>
    <dbReference type="GeneID" id="37158973"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="376" mass="44004" checksum="4509C703EF93E77E" modified="2022-01-19" version="1">MTGKNNTRGISSLPQELYDEVTLFFANYGLEVEDRIARLMCLRLVSVSFNRSATRVLLSAVRLSVSRLLETPQLLHVQSPSSIKSIFTSDLRRFICSLTIFSTGWFVKAVKRPHNNLYRCLKRLPSLQYFEIDYHSQYPHAVVYMLWALERAHRYLPKLREIKIDLPAYSSPKYLAPCLRRLEGVLRTYLPQLQHIDITFVSDWCAIMDDFVDQAFLHLFRLGRGLRSIRLVGISTYANYPEIYNRQSWLHPDAPIEHIELDDFTAPFEVLARIFNYERTLVSLDIRRVFLSTGEWRDLFLKIRKLPLLSHLHIYECYYADDGIYFAQCLTEKDEDAAQSAREMTKKRSEGLPRGQVRMIFPRQAARLSKHGLHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCD0</accession>
    <name>A0A8G1RCD0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanyl-nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_444417</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">COPI-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520999.1">
        <property type="nucleotide sequence ID" value="XM_025659013.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37162415"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030663">
        <property type="term" value="C:COPI-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000003">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000002">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="7">
        <location>
            <begin position="798"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="371"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="775"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1198"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1693"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1980"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="775"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1206"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1705"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1980"/>
            <end position="1995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH63077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2003" mass="224388" checksum="733E95EB90602B0B" modified="2022-01-19" version="1">MAEVENGSVNEPPTQTSTTLPPVDNKEDVAGDVLAHTESPVDGDKPAPPEVSDSQGIDAQGSEEAHSSPEQLETAENTESPGQAPSSPEEAVASSEPKADTEPESTSKPDTQDQPAETSPVVPAVNVEEESSADKQDVASIPHQDEIPSDSRMRSDSRSTTATFATHRSVTVSSTVFIVTALDTIGASKEARRSKELEDAVKSALANVKQSDGQPIDPELIFRPLQLATKTFSIPLQVTALDCIGKLITYSYFAFPSSQDGKTPESEANPEQPPLIERAIDAICDCFENEATPVEIQQQIIKSLLAAVLNDKIVVHGAGLLKAVRQIYNIFIYSKSSQNQQIAQGSLTQMVSTVFDRVQVRLDLKELRLRDGEKGQTGSSDAVTLETADTPQATEDDHDSDAPSAVASDQPVTKEPVEKLTLQSFESNKDVTSVNDNAPTMVTRARGNQRSARSMSAASAEDIDGTSDDDDEDEIYVKDAFLVFRALCKLSHKILSHDQQQDLKSQNMRSKLLSLHLIHYLINNHVVTFTSPLLTIKNSSNSPDAMTLLQAVRPHLCLSLSRNGSSSVPRVFEVCCEIFWLMLKDMRVMMKKELEVFLKEIYLTILEKRNSPLFQKQYFMEILERLAGDPRALVEMYLNYDCDRTALENIFQNIIEQLSRYASIPVTVTAFQQQQYQEHHVKVSTIGNDWHQRGTLPPNLTTASVANVHQPNLQHVPPDYILKNQAVECLVEILQSLDNWASQRLVDQAAPVLNSSSQKSIDNPRDSMETTAATYLSSPRIESTDGSTTPVAEDDPSQIEKVKQRKIAFTNAIQQFNFKAKRGIKLFIKDGFVRSSSPEDIAAFLFRNERLDKAMIGEYLGEGEPENIAIMHAFVDMMEFSKRRFVDALRQFLQHFRLPGEAQKIDRFMLKFAERYVTQNPNAFANADTAYVLAYSVIMLNTDQHSAKIKGRRMTKEDFIKNNRGINDNQDLPDDYLGSIYDEIANNEIVLDTEREHAANLGIPTSAPSGGLASRAGQVFATVGRDIQGEKYAQASEEMANKTEQLYRSLIRAQRKTAVKEALSRFIPATSVQHVGSMFNVTWMSFLSGLSAPMQDTQYLEIIRLCMGGMKLAIRISCAFELETPRVAFVTALAKFTNLGNVREMVAKNVEALKALLDVALTEGNHLKGSWREILTCVSQLDRLQLLTDGVDEGSLPDVSRARIVTQPSTDGSRKSMQASRRPRPRSINGPTAFRTEVAMESRSAEMIRGVDRIFTNTANLSHEAIIDFIKALSEVSWQEIQSSGQTESPRTYSLQKLVEISYYNMTRVRIEWSKIWEVLGQHFNHVGCHSNTTVVFFALDSLRQLSMRFMEIEELPGFKFQKDFLKPFEHVMANSNAVTVKDMILRCLIQMIQARGDNIRSGWKTMFGVFTVAAREPYEGIVNMAFEHVTQIYNTRFGVVITQGAFPDLVVCLTEFSKNSKFQKKSLQAIETLKSTVTKMLRTPECPLSHRGASPEGFHEDATNLSQQLTRQSKEEQFWYPILIAFQDVLMTGDDLEVRSQALTYLFETLIRHGGEFPQEFWDVLWRQLLYPIFVVLQSKSEMSKVPNHEELSVWLSTTMIQALRNMITLFTHYFDALEYMLGRILELLTLCICQENDTIARIGSNCLQQLILQNVTKFQLEHWKKVVGAFVELFSKTTAYELFTAAASISSKSPGSLKPANGESASNEESGQESSETASDQEHVAEAQKANGTQNVTSEHEEGDMPAASTPALEDYRPQADAQQQPAAVTVARRRFFNRIITNCVLQLLMIETVHELFSNDKVYAQIPSHELLRLMGLLKKSYQFAKKFNEDKELRMQLWRQGFMKQPPNLLKQESGSAATYVHILFRMYHDEREERRSSRAETEAALIPLCADIIRSFVRLDEDSQHRNVVAWRPVVVDVLEGYTNFPSDGFDKHIGTFYPLAVDLLARDLNPEIRISLQSLLRRIGEAKLGIPVGQTSLQSGHRNSVSSQYSRKHSGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCU0</accession>
    <name>A0A8G1RCU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_495414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521435.1">
        <property type="nucleotide sequence ID" value="XM_025663916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCU0"/>
    <dbReference type="GeneID" id="37167318"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF3">
        <property type="entry name" value="MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH63513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="265" mass="28192" checksum="F8A08CF065DD54B5" modified="2022-01-19" version="1">MTSVPQASTVPDLLSLKGKVIVVTGAGNPRGIGFEAARGCAEMGASVAITYHTRKDEAMANASTLTSSYGVKARAYPCDVSNFTSVKTLIDSVIKDFDQIDGFIANSGKATSTGVLDGSVEDWNDIITTDLTGTFHCAKALGEHFKQRGTGSFVVTSSMSGHIANFPQEQTSYNVAKAGCIHLTKSLANEWRSFARVNSVSPGYINTGLSDYISNDIKDLWRSMIPLGREGVAKELKALYVYLVSDASTYTTGADIVVDGGYTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCU2</accession>
    <name>A0A8G1RCU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sarcosine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_444610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521239.1">
        <property type="nucleotide sequence ID" value="XM_025659057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCU2"/>
    <dbReference type="GeneID" id="37162459"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF37">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH63317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="432" mass="48302" checksum="3156C2CD2BD4F5F1" modified="2022-01-19" version="1">MDTSRDVPDILIVGAGIFGVSTAYHLAQQLERPSQIVLLDRAAPPSTPAASTDINKIIRADYTNPLYVALGFEAIEQWKSLPSFQEAEVYHPSGWIALEEKDSDVPALIRKNFRDYGRGDVIEEWSEEKVRHAWGGLLEKTDCSPFGSYYYNSSAGWADAGKALQLMAQEAIKLGVRYEVGEARRVVRDEKGVSGVRRADGTIYHARKVLLATGAWTSQLMSSVEDELDLPGPDRVEQQVSAAGVTVSHFQLSSEEKSRYSQLPVFVYGGEGEVIPPTAEGILKFTTAASFRNTIRTASGHEISVPLVDQIHVPEALQEDHLHAIRPRLPQLLEDHPRPDYWRICWDAISPSQHPLITRHPDDRLSNLYFAVGGSFHCYKFLPTIGKYVVNVLYGVSNGSEKDKAWTWKEHHPDERGVHARLAPEREIRDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RE63</accession>
    <name>A0A8G1RE63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_363362</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519567.1">
        <property type="nucleotide sequence ID" value="XM_025655657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RE63"/>
    <dbReference type="GeneID" id="37159059"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="684"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="703" mass="78264" checksum="A54BD3B7DB7640AC" modified="2022-01-19" version="1">MPDLACTRCRERKIRCGRERPHCHNCEREGGVMCLYRIPSKRVNHLKLLCGSIERLQDRLTKIESHLSRLQGLGPRTPGFEEDHESSQPRTLLEDVSATSSCVDIDNEEEHKQEVSGILAPKQSKFYFGRSCVAALCENLKVRVQSVPHATGPIWRPLCEMLQHLCEITKVSEPIPSYSDRLVVPLLPRQQATTAIDRFLQNLDCQTDVFVPDNLRANHQRLYSQHQPQPDDAAWGICFQTITLLARVTSQATQGLLENFVHSFVPSRAVVVCPGLLNTPRLLNVQALLLLSVAAQTFDYSGSAELIFAHACTLARILGLDCSQASDHGDIEQVERGKVLRALYIRDRSLYTLRGSVLWMPCDEYNIATQLCATSNELGKHSTRLHLAMVQEDIYRLAQVGSIPANTHDSQELLMRIEKQLDEYGRTLYFFHGQNAPSECCGSHAIDTMEFLATRILAFQHGQESYHTRQIQQDARLSCLLLLIAHGDQDPAISYCFNVSLTGGKTTPNGNHQSHCFPKVSFTSVLNAFSVPAFFILLQDLLMSRPSETPAGMISDLDLLRRVSACYTDHASQMPANTYHQKIAWVFSQLMSLVRVVVDARLGCHFIDSPRAPAQNDLPSPPYWPVAQQSTAPLYWENWLSGAPSLVLPSLGPVTPLGTWNAGTPALDGEGLMTWPTASGRPPVALTNSHYEQVGDAGDRDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RF15</accession>
    <name>A0A8G1RF15_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_410971</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521147.1">
        <property type="nucleotide sequence ID" value="XM_025657504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RF15"/>
    <dbReference type="GeneID" id="37160906"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH63225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="556" mass="63118" checksum="5B299406DF09572C" modified="2022-01-19" version="1">MMAKQDTQIKATYYVGCACLYVLTRYLGIVPRDSSLLIGGIILSWSISLPLTVCAKTLRKRHRSTFNDLPGPQSLNWLYDRVFDIFDEPLAKNVTDWINERAYPDGLMHFFGLFGSEYIVPTDHEGLVEVLSTRSYDYEKSRAFRRYSVRFFGDSLVTQEQEVHNRNRKTFMPVFNQTNINIVRPLLTAKSRQFNDYISSVLTDVGESQKGSQGSRTAIVPITDIVFRATMDTGSILALGIDLETIKGRNTHMLRAFKTLFASNRQKKIRFVLHNLLPSWIDRLIPSEEEKSMDRAKSLIVDSVVDMMQGKTAENEVTDGHLTYLSNLIRSGRFNHDEYIGQLRTIIAAGFESSGGSLSFVIYCLAANQGAQNSVREELYSAKHGKVELEEDEYDRLPVLNAMVMESLRLFPSFGLLLRRAIRDTTIKGRFIPRGTHIGICPKAINCSRHLWGDDAEDFNLERWIDRSHPNNPTQKPTGGAPSPACMLSFGYGTRSCVGRHLAMAQIKRQIALIVERFHVETEDDRFPHPSGLFASNPPFDFRLRFTEVEYGKNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RFZ2</accession>
    <name>A0A8G1RFZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_515225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520512.1">
        <property type="nucleotide sequence ID" value="XM_025664771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RFZ2"/>
    <dbReference type="GeneID" id="37168173"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="99"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="339" mass="37384" checksum="6E819D24D023D22C" modified="2022-01-19" version="1">MSLTNPQPPYPLHPSVQDKLDPEYVAFYNQYVMKQQQVHLQPVAASRSSGVLIPGGGPVLPVGQTIDLRLPRRVTEGPEVPVRVFVPEGAAPASGWPVMLYFHGGGWVLGNIDTENPVCSNLCVRGRCVVVTVDYRLAPEHPWPAAVHDCWEALLWLTSQGPSQLPIDISKIATGGSSAGGNLACIITQKALTLSPPVRFKAQLLSVPVTDNTASVETNRAYKEYEHTPALPAAKMLWYRNHYLPNQKDWDNPEASPLFWTGDWSALPRALVMVGELDVLRTEGEQYSEKLKQAGVQVDLQVMKGMPHPFLAMDAVLKEGKRSITLMCDLLTEVFWTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VG78</accession>
    <name>A0A8G1VG78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_385109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825090">
        <property type="protein sequence ID" value="RAH51951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509873.1">
        <property type="nucleotide sequence ID" value="XM_025656578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VG78"/>
    <dbReference type="GeneID" id="37159980"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH51951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="754" mass="84040" checksum="FAEA893AA4F7245F" modified="2022-01-19" version="1">MGGYLSVQSKEKRRRTNRLSKPPPNRATLASNSFRASRQTSGTSSPIECPACTAWQDPWTGTSISLQAPEPDVCTRRSQSLPSASYRPGEPWPTLSRARKCQSMVKEPDDLSLYSHVPTVPMPDPVMSGQVSRRSSRHNSFQATTLPSRPQPLMARPPRPRRAYSAHTTPQRAQSTMHHSTIEEATSSNTLFRVDSQGFSLIRRRSLLTRPGIATRRPARDTARRLSSPVVREPTMSLNYFNETSAFPRPLPSGYEDAAGPPSPVTRVRPATPNEFEYTHLGALKLGSLRVVNGSASPCPSDRTRLNRPNSPNPEPTGIHTHDTKPGQPQPYTHQVPCHMDQKLQSASERADEQSHNAEIVQDSGHEVDLTSFDLSNIQDYASESAIEQARKAEIVRDSALEKVDLTSFDISNIQDYAPVPSSDTARVPKLQIPPTEVEKPDDHPASPFSFERSPATSTPYKLRGSETEDEGISVADEEKWFVRQLERSFRDHGHRELQGAHGTVDSGYSSAASVRSTRRSTDSRTSTHQPAVARRFTFNGNSRDRGLLDARNSPELGHEPSVHRHSSLQGPWARPRIDSYGWPSHRWSMCHDLRPMPPKPRLRSSSFATPPEYRHTMPYSQYCHQLRSLDNASPSLSVASADAIPHQYPQWEHVGAFLASSEKSWKQPMTTVTEHDVPGSSSTMSTAWLPMPNIDSLHVPVPESVKGLDTGRPVSGQFRGRTRSRSIESQRKRLTRHAKHPDLYKAASPTIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGS1</accession>
    <name>A0A8G1VGS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nuclear distribution protein nude</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_385298</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudE family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509827.1">
        <property type="nucleotide sequence ID" value="XM_025656588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGS1"/>
    <dbReference type="GeneID" id="37159990"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="8">
        <location>
            <begin position="134"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="278"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="554"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH51905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="605" mass="66414" checksum="DC5CB256D7A67369" modified="2022-01-19" version="1">MPSADASSSARPNGTSSRSDQLAYYKAQYEQLEAELAEFQASSRELEAELEKDIEASEKRERVLKEKLENLRYEVDEWKSKFKQSKSEANTAQNSLQKEITTLRDTNRTLQLRLRDTEVANDDYERQARHTTSSLEDMEQKYNMAIERSVLLEDEVKAGEKEREALRIQCQRLRDELSEQKLDNEILQEKLRHEQYGGRRKKPTPLSRTSSSTPQAPEIFDRSPGTSAVSSPLFVRTPMKSTLMGVTAAPPSPPMSETSVSVTNMMANMRKTVHATAGFPLQKASGSESLMGSRSMYDARPNKSSRSRTTGNASNNTRSTASTATSRISLTKPANFGNSINSINSPRSENDDQKSSLPKSGSLFQIRGLIGKMQQLEERVQSAKSKLPPPSDSPSRASSRSGSISVNGGSPVASTITMRRNSRKRLSGSSFSSSIRDNDGTASSVSNNRPSFGTRNGGDSRPSSRTSYSSAFSQSTHPSVAPSTRPESRQSRTKTPLGHYSTNPTTESRRPRSSLSNPSGQNGSVNGMSNIDEDEDQSLAFRLSVQAKISEARETRYPPYSTATLPKRRTPSGIPAPRTLRTSTGGGMTSPDPKATKFGDLGETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGS8</accession>
    <name>A0A8G1VGS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_507196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510518.1">
        <property type="nucleotide sequence ID" value="XM_025664391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGS8"/>
    <dbReference type="GeneID" id="37167793"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="281" mass="32525" checksum="FC15DA8ADE750350" modified="2022-01-19" version="1">MSTFTAWQADLFLLEHWQKDLPLSVEAQREEIFAKYVALGVCGREPYRNQQRRLEKRSVRGLPVPSQELLARIRLPAERDLNEDPCWLRTCYDPSTEGSWARIQDYIDTKVGGPVTVFNDSSLYNFGPNWEKIFLRVPQLLDNTCLFEEYEENVQEALEEGIESDETDPHRAEESGYDPEEDGNPWICFYSEYLFRLAAGHIYIVDEKTLASEGADAGTVLIIWYDECGRAIRYYREKAMHAAEIANLDPCYLKERACWNNAEIGESYKWGAPLGPPYRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHF0</accession>
    <name>A0A8G1VHF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
            <ecNumber evidence="2">2.4.1.183</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_405841</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511238.1">
        <property type="nucleotide sequence ID" value="XM_025657314.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37160716"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11323">
        <property type="entry name" value="AmyAc_AGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000058">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058656">
        <property type="entry name" value="Mok11-13/Ags1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF2">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26108">
        <property type="entry name" value="GH_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034106161" description="alpha-1,3-glucan synthase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="2395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1969"/>
            <end position="1991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2003"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2027"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2062"/>
            <end position="2082"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2138"/>
            <end position="2164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2184"/>
            <end position="2201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2221"/>
            <end position="2240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2247"/>
            <end position="2264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2321"/>
            <end position="2343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2367"/>
            <end position="2387"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="10">
        <location>
            <begin position="69"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1139"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1653"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1795"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1139"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1680"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1731"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1795"/>
            <end position="1813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH53316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2395" mass="267812" checksum="1178BD2FA94CBE0E" modified="2022-01-19" version="1">MKLFIVIYRYLFTIALLSRIAQSLPHLPEEVDWNLNQNETATNPLDYSGQWDGHSYTPSPDNWRFPFYTIFLDRFVNGDPSNDDANGTQWEHILTSNQFRHGGDVLGLVDTFDYLQGMGIKGIYLAGTPYINFPWGADGYSPLDLTLMDHHYGTIDDWRTMISEAHQRGIYVLFDNTFGTMGDLIGFQGYLNRSAPINPSEYDYVWKYDRQYWDFKPGNEIESQCPWEYPRFWDDDGTGLTTTTLGASCRDSEFDQYGEVAAFGNYTEWEGQIAKFAFVQDRLRSWRPDVLAKIKHFSCLTITMLDIDGFRVDKALQVTLDQLGEWSESVRDCAQQVGKDNFYIPGEIVSGNAFGSLYIGRGRQTNQTISNITEAFMMTNKTDKATEDLFLRPTSQSALDGAAFHYTLYRGLSRFLGLDGIYAAEGDPPVNFIETWNGLVETNDMININTGKFDPRHLFGVTNQDVFRWPAIANGTHKQNLGLYIASLLMPGIPILSWGEEQDFYILDNQADNYIFGRGPMSSAQAWQLHGCYKLGASKYVNLPLDRALTGCGDDSVSLDHRDPSHPVRGLIKMMFEMRQNYPVLNDGWYLQQLSNHTFDIYLPGSNGTPTETGMWSVMRSRFTDLQNFDGQGQGNQSVWLVYSNDNKTVDHQFNCTSKDALISPFPAGTTVKNLFYPFDEYTLINSSVRLGFEGSELPNGCYPQLTMPAWGFKAFVPKAKFVKPSPYITRFSPGHDARFISQGNDGETIQIGFEFSQEMNCSQITDSLTVTSKALNDESARIDKNSVSCSSFAEIQVATFPGALTSVFGYQVNLTNVYPGVHRITVSNVTTTEGNQSTNSVDHFMFRIGETNNPMVWPQLANYSRTLLFDTPSPATDPLSVRPQAPGADMWRYSLDFGANFSPWMAYTGFNTSIPGKNWTGTAKQAWDGEHIIAQYWSKLTGSSDHWQHGDSQWQYKPPRRFPNLFIEGEFNQFGYDAGYSNTMSLSNVTGDWEIHFMGEWPVQVAFNAWGINEDGLPDQTQVYGDIDGDNVLDQVPPVTLLSNVFNVTIPPPSPYLAFKLSVNDGDLRVYATPTGSRWVQLALFILLAVIPVATAVGAVFIYLKAFYQVKFNQVGVTEKTSTFAPLLGALMKITRSSNEKEASPEETQRSVSPSGLPTGSAIGAIVNTPRRTVLIATMEYDIEDWAIKIKIGGLGVMAQLMGKNLTHQDLIWVVPCVGGVDYPRDDPREPMVVTVLGTTYHVDVQYHRLHNITYVLLDAPVFRAQSKSDPYPARMDDLNSAIFYSAWNQCIAEAIKRFPQIDLYHINDYHGAAAPLYLLPRTIPCCLSLHNAEFQGLWPMRNPQQIQEVCRVFNLDQAVVKKYVQFGDVFNLLHCAANYLKIHQNGFGAVGVSKKYGKRSYARYPIFWGLKSVGALPNPDPSDLADWDSNASKQPEEVTIDLEFEASRGALKKQAQEWAGLKVDPDAQLFVFVGRWSMQKGVDLIADIFPSVLDAHPKVQLMCIGPVIDLYGRFAALKLNRLMELYPGRVYSKPEFTALPPFIFSGAEFALIPSRDEPFGLVAVEFGRKGALGVGSRVGGLGQMPGWWYTIESMTTKHLIHQFKLAINDALRSSQETRAMMRARSGKQRFPVAQWVEDLGILQTTSIIKHAKHSKSQDRNSWRVSGVSTMVPDRPRNFRFSSSSNTSREQSRSRSSDNSGPPSRPITADAKQAVARPGHSHVASLPANLPSNPNMFNDSDTDNEPRRRPLSSTPRGGPRIVYTHGNDDQDLENITSVTQDDFSPHLASYLSPSGAPNTPPTFANSGASTPTLGAGPDDGLLGRRNLSPSMMSLVSIHDIVKEKQDYNLQKVNPFFTDANHEYAAKFERKLAGLNGKNSEDQLCIEEFIEKSEKDWFNRYRDVKLGKSPLPSPSPSIFRFKVQDASRPPTPPVNGPAEDPNGGQFLLPKDYVPPTGLKRFMLIKLGDWPLYSIVLAIGQILALNSYQITLLNGEIGETAEKLYILASIYLASSIIWWMVFRLVPSVYVLTIPYLLYGLAFLFVGIAGPIGNSTSQTWLQNVGTGLYSFASSSGSIFFALNFGDEGGAPLSSWIYRATVIQGSQQLCISFLWYWGSWMASLNQEGSTRFSLSITDPNVLLGVGIGLACVLWLLGALVFFGLPAYYRQTPGRVPTFYLSLFRRRVILWFFYMVFISNYWLSAPYGRNWLYLWSSKHAKVWQIILLVLLFFVVVWAAALWVFHVLSKRHAWFIPIFAIGLGAPRWAQILWATSNIGTYIPWAGGPVAGAILGRALWLWLGVLDSLQGIGFGMILLNTMTRFHVTFTLLAAQVVGSVATILARATAPDKLGPGNVFPDFSAGVTAGLSKADFWVCLLLMLSINVICIFFYRKEQLSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHN8</accession>
    <name>A0A8G1VHN8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_453739</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510757.1">
        <property type="nucleotide sequence ID" value="XM_025661119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHN8"/>
    <dbReference type="GeneID" id="37164521"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="13"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="105"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH52835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="557" mass="64538" checksum="828D25D0F8881B65" modified="2022-01-19" version="1">MVTAPSTSAARKDTILSRRYIEGLISEGKHVIIFDGRVLRVDAWIPYHPGGDKSIRHMVGKDATDEINALHSKEARQRMLSFQIGRIEGPWVNFLPPIQGGKFRPYTEDCLSDEESSDQESSGQETSQPPSPIFDAVDSTSGARQRKSAPATPASAAKSEEFQPKPFFLDARTQEELVFDTAKYPSLDLDNQEKIKQRYRDLDRQIRAEGLYDCRYFSYFIECCRYTLFAALSYYFLQIGWYATSGFFLGCFWHQLVFTAHDAGHMGITHNFHVDTVIGIIIADYLGGLSLGWWKRSHNVHHIVTNAPEHDPDIEHMPFFAVSHRFLTSLRSTYYDRIMEFDAAANFLLRFQNYLYYPILLFGRFNLYRLSWEYLFTGQAPKKGPAWWHRWFEIGGQVFFWIWFGYGVMYRSIPDWSSRLAFLFVSHMVTSPLHVQITLSHFAMSTSDMGVNESFPQRMLRTTMDVDCPTWLDFFHGGLQFQAIHHLYPRIPRHNLRRTQRLVLDFCRDTGIPYTIFTFYDGNKEVIGKLGDVAKQVRILEECRKSCAENGVFSDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHV3</accession>
    <name>A0A8G1VHV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNase H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_382508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510952.1">
        <property type="nucleotide sequence ID" value="XM_025656469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHV3"/>
    <dbReference type="GeneID" id="37159871"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="530" mass="60978" checksum="E6CA200A7FC375E4" modified="2022-01-19" version="1">MSPSSESNIFIYADFDLEAVCHRASTLRQGISCTCDPGQRPASGSFNWAIFILFEDGIQWVLRSPHPRTFMPLDVGVKLLASEAATLRYLKAHSDIPVPEVYDYCASSDNDIKVPFILMSQAPGWPLSKVWVSAGSPLPDLDPSKKDKIMTQLGGITWKLSQLRLDQIGSLYDDDGAFKIEECLWRCYMLHERFLLEGQRGPFTTDSDFYESLVSRFLEQAECLRLSHHCFVAPVPSRDDYQSDKQYRQAVDLWNDFVTVGNKIDSADNRLDYIVAGDALRDIVRKLELPTSNPGAFPLCHADLSVNNIYVDDDYNITCIIDWAFTSSVPESMLLSPPGLPQYGDKISPVLHTAFIDGFQAAMSESTEESTVRRYHEPLKQGSFHWNLSRLLGLDSIGDYNLFTAVWQSTYGPEKDIGEYFSQQRRSPHYLRLYDEVREEDRPLWKVERDEKDYFRNKVFKHTIAKKLTLMSEWKAKYTADSPRRIRQDMFVASPNLWKWILRFMEDWEEMLDTDANVKKEFLRDLALHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHY3</accession>
    <name>A0A8G1VHY3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_383270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510624.1">
        <property type="nucleotide sequence ID" value="XM_025656512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHY3"/>
    <dbReference type="GeneID" id="37159914"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034968317" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="23"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH52702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="529" mass="58011" checksum="4EBC03DA21A78839" modified="2022-01-19" version="1">MLRNTLPTLLGLASVSSAALYETKIETKYGSVQGYPAFNSSNTGNLTHWKDITVWKGIPFAATTGGANRWKAPQPAGPWNGTLDARNWGPVCPSATTGDNSYTINEDCLILNIWSPANSTDAKLPVVMWSYPAESTAADPLFDGGGMADKGIVFVNYNYRTGPFGWLAHSELSEEFEKVTGSNSSGNWGMLDQFAALKWIHANIEAFGGDPNQITVQGQSAGSAATQHILYSNLTKGLIVGAIIESGVRDPHDPLCTSLAEAYTTLDDALDDGNTYLSNLGVSSIAEARNLSMEALIDGATGSTREDTIMFEAVLDYYAMPDTYLNILKKGLAHDVPVITGNNKDENGATYGLDISLAEYLEDLNETYSGEWVERFFDLYPANDSTTASGAYNSMFTDRSKVGTWLWTQMWYTKKSSPVWNYFWDHAPPGQSSGAYHESEINYVLNNLYATDKPWTAEDYAIAKNMNDYWASFIKTRNPNTQAEGATEWPAVNTSKLVQHVGDGWGQVPIAWSKKVKLFEDWVATLVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIL2</accession>
    <name>A0A8G1VIL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NTF2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_503902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511702.1">
        <property type="nucleotide sequence ID" value="XM_025664264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIL2"/>
    <dbReference type="GeneID" id="37167666"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00531">
        <property type="entry name" value="NTF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02246">
        <property type="entry name" value="SgcJ/EcaC family oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="82"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="206" mass="23210" checksum="C0EF1972E6D82829" modified="2022-01-19" version="1">MSRLTLPKSLQSVPHEMPNPHLSKWGYPFLDRKATYKAKYSLVSADTFLKSLSSQSLLLHSRNKQAIMSPTHADEISALLHAYGKALKSRNVDEAVALYTEDGVIMPPHFSASTGTEALRDSYTRIFATIQLVITFQNEEIVVMSPEWAFARTTAEGTKTILATQESEPHANQELFILRREHGKWLIARYAFSSMKSLVQNGIRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ44</accession>
    <name>A0A8G1VJ44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_452287</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512242.1">
        <property type="nucleotide sequence ID" value="XM_025660783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ44"/>
    <dbReference type="GeneID" id="37164185"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH54320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="341" mass="37961" checksum="F0075F293A30E3C6" modified="2022-01-19" version="1">MPNVFTDQIEVFCRGISEREKVCVSIHPHNDRGCGVAAAEMAQLAGADRVEGCLFGNGERTGNVDLVTLALNLYTHGISPRVNLSNLNEVVAMAEECTKIAVHPRAPYAGKYVFCTFTDTHQDAIRKGYNKLKESERLGATRASKWKMPYLPMDPVDLGRQREAIVRMNSQSGKGGGAWLLKESFDIDMPRDLEIEFTQVVKAHANTSGFEVTRETICRLFRKHYMHVESERFRLLNCRANQAKGNRDATLVQLKTSVQGSDHELEATGGDLLPTILNALRSVGYDYEVPDNQLQYIASQDTMRSLVRLGTAENIASWGVGMHKNTDWAVSQAVNQADVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ53</accession>
    <name>A0A8G1VJ53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">glucose oxidase</fullName>
            <ecNumber evidence="12">1.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_490325</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2</text>
            <dbReference type="Rhea" id="RHEA:11428"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.1.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:11429"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
            <location evidence="3">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.4" evidence="12"/>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513156.1">
        <property type="nucleotide sequence ID" value="XM_025663656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ53"/>
    <dbReference type="GeneID" id="37167058"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046562">
        <property type="term" value="F:beta-D-glucose oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9 14 15" id="KW-0274">FAD</keyword>
    <keyword evidence="8 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033988081" description="glucose oxidase" evidence="16">
        <location>
            <begin position="18"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="17">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="18">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="568"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="36"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH55234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="588" mass="63681" checksum="54A08D96A8215021" modified="2022-01-19" version="1">MLLSSLALAAFSLGAAAKSHTGSSPHYDFVIVGGGTSGLVVANRLSELKNVTVAVIEAGESALNNFNVSNVMGYSTAFGTDVDWAYQTENQTYAGGLQQTIRAGKALGGTSTINGMSYTRAEDVQIDNWEVLGNEGWNWKNLFQYYKKSEGFQVPTKDQIAHGASYNASYHGLNGPLKVGWPTSMTNSSVFPVLEQTFEKLGVQYNPDSEGGKMVGFTVHPDTLDREMNVREDAARAYYWPYEARSNLKIISNTRANKVIWANSTQGEAVAVGIEVTNAYGTETIYADKEVILSAGALRSPALLELSGIGNPDILNKHNIPVKVNITTVGENLQDQTNNALSWEGVDTLTGLATFSVLPSVNQLYGDNATALASYVKSQLASYAKTVADASNGAVKEANLVEAFEYQYDLIFKSQVPYTEIVFAPSGQSFAVEYWPLLPFSRGSVHIQSANASDYPAINPNYFMFSQDAEAQITVAQYIRKALGTAPLNSLVGEEVTPGLDVLPADASSATWTKWVQQNYRTNYHPVGTTSMLPREKGGVVSPELKVYGTKNLRVVDASVLPFQLCGHLTSTLYAVAERASDLIKESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ93</accession>
    <name>A0A8G1VJ93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_502602</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511974.1">
        <property type="nucleotide sequence ID" value="XM_025664203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ93"/>
    <dbReference type="GeneID" id="37167605"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="10">
        <location>
            <begin position="375"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="218"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="683"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH54052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="762" mass="85299" checksum="8AF85C32FF550E6B" modified="2022-01-19" version="1">MLGWSSGAYYRIQPNRSALLQTQPLRRGPQLPRLGINGVLRLVSAADGKKFAVMAPYPHARIARELVWTVWKGELRLLCPEGGFPPCRLYYLERRVRELERLEALPLRDNADNAESTDNSRSACDQNALFDGHNASPTPAPVVVENHGIHLVEDHHSPAVQSPAVSGSTQITRNQPLAHEVGLLSLANNTEPKYLGPSSGISFARLIYESAPQSQGLPLSLLQGQGTHKHPRVLPPTATGRAPSSDASSIPPIPLPSPAECQQYAEAYFEGTYLYPFISQQGLYQLLSQIQKYNESSTWNHPLPIRLAAAQVGLVLSLGARFLEVRLGSDFDSSDLFVSAMTHSSQICLQDSMEGVQILLLMVLHSFYSPEGLNAWYLLHTIIASCLDLGLQRRNEYAAELNSATYRLAAQRRSAIFWSAYSMDRTLTTILGRPLTLRDEAIDQPFPGLDASDEVEEAATRWDSAKMTHHPFEQIPSTYLAFIYSLRFDRITAEIKLMIYRVSRSPRRFPWPSNISSWQRETDQACKNLLTEVYTQQRGRSVCGPSSLSGTTVQRLEIKFHQCIMLLYRPSPQLPYPTFAAIESCFGSAMKIIQINTELHRFRNMEWSWLSAHTIFVAAITVLYCLWAYPAVRDLTPATVPLSRVDSALELLTFLKQRWSVAEEPCEKLSRLIALTHETMRETAENQRRSATADDITTHPPAETQLGNGVSMVPQEDGRSLLIDELGILRDLFDLGWLSDWGSDATQPPVWDTSELLRGFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJP5</accession>
    <name>A0A8G1VJP5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_500478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512409.1">
        <property type="nucleotide sequence ID" value="XM_025664125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJP5"/>
    <dbReference type="GeneID" id="37167527"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="310"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="742" mass="83178" checksum="38C65437775D91EB" modified="2022-01-19" version="1">MRASPQVPYLDYKPRYDGGGFDAFPSRCGIDTDKLQRGDLGAHTIDSIIPFLQEWLFFGLLQEVFEVAHVQFRREDFVAKATAIPGQYRISTANLPKYLWSWTANTVWVRDNFGEFDHQKRRVEEVLKLSNLCLNAVIRLQAAQRGTEPATGPVLLSLAIVGESLDSERDTVFLSQREEFYGTLTWETPEFCRKLLLEAGCCIGEVNALRRDFPSVSSLYYLATWDRSASKADHSQCAETCLARQIDEKTYATKHTGEGCSCHHLPIDMTAIFNIVDQGQIPLILFSNGKVRVQQSPSGNIDEDTRPVPYVAISHVWSDGLGNTKANTLPRCQLEKIQQLVNALYQGVYGHRNEVPFWMDTLCVPLESIYRKKAIRAMSEVYMRAEKVLVLDASLQIIDVRAPIHERMMRVVTAPWATRLWTFQEGVLAEQLHFQFCGGTIRPTALEARSQTEGKSHIALANFLCRNKSAPELPGESTLLRLEIGNDMNTLFRSLRGNFSSPVYLSGVKAMMKILGGHHLRDMSPFPNLHSLQLPSSVGIRTTSKAEDETLCLAGVLGLDVQPLLDCDKADRMKTFVSLLDTIPPDLIFAPGPRLQDAGYGWAATSFLGAIHEPLTQLIQASRLLQPGLLQARGLRVVLPGLRVRKSVLPESDVVFAFDGYSRMKLQLTPGGRWSTYNGSDGLMVMMSQYTERGAVVLLEERLEGTWYVKFQELLTVEVYESVFEPSVSAEEPDDDTVWCVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK45</accession>
    <name>A0A8G1VK45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HNRNP arginine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_451806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512844.1">
        <property type="nucleotide sequence ID" value="XM_025660675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK45"/>
    <dbReference type="GeneID" id="37164077"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000050">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="67"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="6">
        <location>
            <begin position="169"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH54922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="348" mass="39485" checksum="34221E14FDC62622" modified="2022-01-19" version="1">MAGEADSAAMTTSSADRMVGMDHAEVRYFTSYDHHGIHEEMLKDDVRTRSYRDSIYQNRHIFKDKVVLDVGCGTGILSMFAAKAGAKHVIGVDMSSIIEKAREIVAVNGLSDKITLLQGKMEEVVLPYPKVDIIISEWMGYFLLYESMLDTVLYARDRYLVPGGKIFPDKATMYLAAIEDGEYKDDKIGFWDNVYGFNYSPMKQIALTEPLVDTVEMKALVTDPCPIITLDLYTVTPADLVFKVPFSLPAKRSDFIHAVIAWFDIEFGACHKPITFSTGPHAKYTHWKQTVFYLRDVLTVEEEEVVSGVLENKPNDKNKRDLDISISYKFETTDPNRYSEGSCFYRMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKC7</accession>
    <name>A0A8G1VKC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_489204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514328.1">
        <property type="nucleotide sequence ID" value="XM_025663586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKC7"/>
    <dbReference type="GeneID" id="37166988"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034277357" evidence="1">
        <location>
            <begin position="20"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="206" mass="21879" checksum="B0D90543C3F2FB38" modified="2022-01-19" version="1">MQLTTFLFTLVHLLALTSAAMTGNFMGLGSVFNTTQTAIQRLQQVAGHLPDTSSLNLTGLNLTNVDLNLNLTQLANRTGSYVDAAKPQIARAGNATKDYVVKHPYQTIFSIVGIVYPGGLLNLVGYGRLGPWAGSLAAWSQSYLGNPVARSVRACLQSAAMNGYAAAPVLNTVRGVIVSAGGYMVWKEGFNNGKGEQQEGKEGKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKL6</accession>
    <name>A0A8G1VKL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_398880</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514598.1">
        <property type="nucleotide sequence ID" value="XM_025657073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKL6"/>
    <dbReference type="SMR" id="A0A8G1VKL6"/>
    <dbReference type="GeneID" id="37160475"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="18"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH56676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="379" mass="39899" checksum="A13CAE2D912C77C5" modified="2022-01-19" version="1">MASTVGQTITCKAAVAWGAGEPLSVEDVEVAPPKAHEVRIQVLHTGVCHTDAYTLSGKDPEGAFPVVLGHEGAGIVESVGEGVTSVKPGDYVVALYTPECRECKFCKSGKTNLCGKIRATQGKGVMPDGTSRFKARGKDLLHFMGTSTFSQYTVVADISVVAVTPKIPTDRSCLLGCGITTGYGAAVVTAKVEEGSNIAVFGAGCVGLSVIQGAVKNKAGRIIVVDVNDGKEAWARKFGATDFVNPTKLGGKTIQEQLIEMTDGGCDYTFDCTGNVGVMRAALEACHKGWGESIIIGVAAAGQEISTRPFQLVTGRVWKGCAFGGIKGRTQLPGLVDDYLNGQLKVDEFITHREKLSEINKAFEQMKAGDCVRCVVDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLD7</accession>
    <name>A0A8G1VLD7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_439156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514552.1">
        <property type="nucleotide sequence ID" value="XM_025658699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLD7"/>
    <dbReference type="GeneID" id="37162101"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH56630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="147" mass="16718" checksum="B059A84155EA546A" modified="2022-01-19" version="1">MYGPTTAKLALKQRSQTDLYLSTHLIQTKSYSRYNISDNHNILPSFSGGRLLQETTKFIGYRGGVGASAISLRAGQAQRAYLGTETDSTIYTAELKDIEIILILAESTLLRYNSEVNLYLLPREPFTKIYIQRIRLIYFLYKIKVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLV5</accession>
    <name>A0A8G1VLV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL5m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_399214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514764.1">
        <property type="nucleotide sequence ID" value="XM_025657088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLV5"/>
    <dbReference type="GeneID" id="37160490"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="6">
        <location>
            <begin position="190"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="7">
        <location>
            <begin position="250"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="354" mass="39486" checksum="078AE6009F7CC551" modified="2022-01-19" version="1">MAASEPSRYLARSLPRAFAPSSRAPAFCWRRNASDQASTRSPSAAINDLESTTLSTPLSEDTVKSFNPLERARARKTQLPRSRYQFRSPKYDRGPLHPHRPPPPSDPSSRLFVPGPFSLPRVAQTWQSTVAPDLLTLLYVHNPPGFKPPPKAPRLRSWDDSSPYHKNRSLRGPRGGDVLRLLRKPITFNNIPKIERITLHSYVKQAAQYDSSWLHVAGMALQAVTNVKVETFKSKTSVAQWHIAPGRDTVAAKAELRGENMLHFFGKLVDVVMPRLKDWQGVKGSSGDSSGNITFGLEPEEMALFPEIEVNYDMYPPKMIPGCHITIHTSANTDKDARLLLSAMGVPFYGKLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN35</accession>
    <name>A0A8G1VN35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_448282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517283.1">
        <property type="nucleotide sequence ID" value="XM_025659900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN35"/>
    <dbReference type="GeneID" id="37163302"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="393" mass="43033" checksum="4498F837649BBEC7" modified="2022-01-19" version="1">MRRRTRRSLFHLAIFAGILGLILFLNRPSPPGRPFAWTTITYETTAKQLPEARGQCPGLAKTDKPVLVVSRVTADASDWLAPLAEQYHLCVYTADAPPDPRSTQLQVPANRGHEAMGYLTFLIDNYAQLPATGMVFVHGSRWAWHNDAPDYDNAALLAALNISAALAPWGYHNLRCDWSVSTCSPKTPAQGSLELSMQSVLEPWSARTASDVALPGALANLFGKDQISLELESARVQLGRNDAVRAQCCAQFVVSRESVWQHTRDEYIALRQWLLDGSDDAQSGAGGAEGGGERRSPSARRAAPRDDRIAGRILSYLWHILFIRRGALHADGGSAAIDLERLNGIACPRADECYCRLYGRCNLGRCNAGSCFGQYQLPPDFKVPAWVTEKGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN69</accession>
    <name>A0A8G1VN69_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginyltransferase</fullName>
            <ecNumber evidence="2">2.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_447467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="2"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517506.1">
        <property type="nucleotide sequence ID" value="XM_025659730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN69"/>
    <dbReference type="GeneID" id="37163132"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="6">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="7">
        <location>
            <begin position="176"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH59584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="450" mass="51806" checksum="9B91F344EAC8B152" modified="2022-01-19" version="1">MEPIVDAEQARKLSLFRPLGYQRNSCGYCKSDNGSASYYASSVSVRPAHYEALVNRGWRRSGTLYYKQNLQRSCCPHYTMRLEASAFTPRKDQRKAINRWNKFVLGPEYIRRAAYLCPKTREEKKRRKCNFDLLGAVHEAEYSNVKRPIDPKTKRPLEPAHRFEVNLEGDSISQAKYELFLKYQTKVHKEDASKWANKDFKRFLCSGMTRSPANAAKSDENKLGSWHQCYRLDGKLIAVAVLDLMPNGVSSVYIFYDPEYEQWEFGKLSAMREIAFAIEAQYQYYYMGYYIHSCQKMRYKGTFRPQYILDPESHTWDPLDGELSKKLDERPYVSLSRDRQTTTTTTTTTTTTTGDNNTATQEEADAEINDEEVSLFDLNMPGNMTLDEIKALDLDHWLLLVHGTFVHMIDLVGWEKMPIDNPQSVKGIIAELAAVLGPEVVKNSAVVLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPK5</accession>
    <name>A0A8G1VPK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_517130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518813.1">
        <property type="nucleotide sequence ID" value="XM_025664886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPK5"/>
    <dbReference type="GeneID" id="37168288"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="41"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH60891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="392" mass="44597" checksum="31E7161DC6DBE3A3" modified="2022-01-19" version="1">MEDSSFEYPSDILYTQEPLSGYKFGGYHPVRIGDTFKDNRYTIHHKLTWGGFSTVWLAHDNLRHRWVSLKIKTADTSYSSQELPNLQQLEKIAAPDDLSSKYILHLLDAFIQPGPNGIHQCLVFELIGPTIDRIITDYRELSDSLDPQTILRLSRQLLKAIELVHNAGVGQIDISGRNIVFSGRNLSYASEKIIFAVFGSPEHEPVTHLDGTPLHKGFPAALFGPVSWEDWLEEFAEELRIFDLGEGFAQEEKSRILAQPGPSRAPELIFTGRSDHRTDLWHTGCMLFFFVFGTYPFDSDVEDMVVVEQMFDLLGELPQEWQPIWNRMRAEAGDMMDFQGDEVFTLEDRFDKEVAEPELAPLIPIIRALLEFRPSERITAPQALSLLGSQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPM5</accession>
    <name>A0A8G1VPM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DDHD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_370959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515800.1">
        <property type="nucleotide sequence ID" value="XM_025655982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPM5"/>
    <dbReference type="GeneID" id="37159384"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055555">
        <property type="entry name" value="PA-PLA1_DUF7131"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057826">
        <property type="entry name" value="WWE_C20G8.02"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23465">
        <property type="entry name" value="DUF7131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23463">
        <property type="entry name" value="WWE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="3">
        <location>
            <begin position="589"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="617"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="765"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="802"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="348"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="765"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH57878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="894" mass="99865" checksum="62EBBD3AE6EB7E11" modified="2022-01-19" version="1">MSKDSQRGTFFGAFTPGKPPRSTTPQPDNGTKDLLQRSRGEDHTVSHRHGLSPRRYPKDCPPLKVRWFYAVDSPKWKPGPRDQKGDSKPLAPPKKFVPFISRDSEAVEDAFQALLQSDVENEHDSYNRSVGGASSEPTKVPVNEDSLFDVIIEQRELRPAYWTGPVYEVRRGTWFFQDGSTTKPCEENLATQLEEGYLKSKPWRYTSPTYSAKFPSENLGHTTPVARNEPETYRLFGAYMNSIVTYQDSKTALLVNDDFMSRVSTTVYQKLGGIPGTKLVRGYNETNKQKEAEDKSGVEMKSSGEELQEVLPGDTQERTVSQMGGPFTSRYQTSDDEGISVEEKPTVEQRVSTDMAELEERARKQAQREMEDSRKVEDKDRGIDHLVLVTHGIGQRLGMRLESVNFIHDINVLRKTLKSVYRASPDLQALNSDFPDKHENCRIQVLPVCWRHLLDFPYQKEHQSRTEFDLGDAKGSESTPYPSLSDITLDNIPAVRGLISDLAMDVLLYQSDYCEHISRIVKQECNRILDLFKKRNPSFRGSVSLCGHSLGSAILFDILCHEQQNSRPTEASHCGYDENHDKVIQGDNLDFDCDDLFCLGSPIALFQMLKGKTIAGRPQRQYASSSTRPEGENGTVKSQSSSSVLHDYGNDKLQHHTLTSISSPKCRQLFNIFHPSDPVSYRLEPLISPAMSSLKPQPLPSVKRGIWTTSGQSLSLISSRVGQSVGSLWTNFTSGVASSLLNRSLGLTSEDTASSEVGLNTTLHAQKSQSSADPGSSHQTEDIRNPTLIDSNLETLYEGYRKAGEGGKPRDSQSNVGDSFESLGTDHHGRRLMIEDAKVRTLNSNGRVDYSIQEGAFDISMIASIASHLSYWSDEDVCHFMMSQMLCRRPGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQP9</accession>
    <name>A0A8G1VQP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_447994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516925.1">
        <property type="nucleotide sequence ID" value="XM_025659835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQP9"/>
    <dbReference type="GeneID" id="37163237"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="36"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="292" mass="31926" checksum="F7C5A3CBD701347D" modified="2022-01-19" version="1">MILDSPPPSFSTLSLTVNDHPLKLSTLYRPGPKPAILFLHGFGSCKEDLHDLVYLPSLRDHTLIAYDAPGCGASESYGPSSDLTISFLVATAQAVLKQFHITSFYLIGHSTGALTGLMLAASLPPTQYQLLAFINIEGTLSPENCFFTRSLYTELVKPNPSSSPEDDLQKLIAHAHSTPGYSHALYASLLPSRVRPEAVRPLVTSAVELSWKNLLGRFLRLSCPLMYMFGDQNREVSFLSQLEMKGVELAQIPTSGHFPMYSNPAKMLRRIEGFFRDCTYAGSTSSGSGGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR07</accession>
    <name>A0A8G1VR07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_134107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520313.1">
        <property type="nucleotide sequence ID" value="XM_025654018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR07"/>
    <dbReference type="GeneID" id="37157420"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="108" mass="12762" checksum="D096CBE07303A49F" modified="2022-01-19" version="1">MHRIDYLSTYLFPQSKVQIATNSQTSLALPLQATAYSAPLMRRIREKREGSKVLQIHKRTREGLRVNVRYQFDFFMLLNFNQYFAICCCCCWRSQVGRSWKGNLSLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR28</accession>
    <name>A0A8G1VR28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_409814</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520581.1">
        <property type="nucleotide sequence ID" value="XM_025657449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR28"/>
    <dbReference type="GeneID" id="37160851"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.20:FF:000005">
        <property type="entry name" value="NADH pyrophosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000042">
        <property type="entry name" value="Probable NADH pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="251"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH62659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="417" mass="46108" checksum="D96713ED12E97088" modified="2022-01-19" version="1">MMSNDSQLPNPPHIQADSMLARRFGKETVNYFSSSPLNRLSFLRGDHAFLSAALKHPSTRFVLMKDLAPLTKSPAEPYYAKYDEIRKMVPETIYDKSEEDIIKEYDSRKTTASPIFLGLDETQKQDGLVWKIYTGTPYFALDVTPRHSEEQQANSRAVIADMEAKGLTFLQGRTIMSFPASEAAIYAQARALIDWNTRNTFCGTCGHPTISVNSGTKRACPPSDAALIEQGKPATRPPCNTRTTISNLSFPRTDPTIIVAVVSADAKRILLGRSKRFPPNWYSTLAGFIEPAESVEDAVRREVWEEAGVTLSRVVIHSSQPWPYPANLMIGAIAQVSDPAHEKINLEHDPELEDARWFEFAEVEEALRTGTSVLGSGPGPEYKEGALRLPPATAIANQLIRAAINLEFLGGENGPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR70</accession>
    <name>A0A8G1VR70_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_516161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519459.1">
        <property type="nucleotide sequence ID" value="XM_025664831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR70"/>
    <dbReference type="GeneID" id="37168233"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="107" mass="11648" checksum="697634FFD4FE8929" modified="2022-01-19" version="1">MNNLAVIPAIPILLTIIIGIFLIPILILAAIPTGIFLFCVAVCGVIAVVVFGLFSMFFISPVILVVAAITWFFVLTYRACRFAFTVLFGLLVNRLWPPGPLPNGWAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRK2</accession>
    <name>A0A8G1VRK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytoene desaturase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phytoene desaturase (3,4-didehydrolycopene-forming)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_361703</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521076.1">
        <property type="nucleotide sequence ID" value="XM_025655597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRK2"/>
    <dbReference type="GeneID" id="37158999"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016166">
        <property type="term" value="F:phytoene dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000171">
        <property type="entry name" value="zeta-carotene-forming phytoene desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008150">
        <property type="entry name" value="Phytoene_DH_bac_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF1">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00982">
        <property type="entry name" value="PHYTOENE_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="10">
        <location>
            <begin position="14"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH63154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="599" mass="66775" checksum="E85762750A1E38FF" modified="2022-01-19" version="1">MEPPTAIVVGGGAGGVAVAVRLAKKGYKVTVVEKNADIGGRCSLMQEDDYRFDQGPSLLLMPSFFHQIFHDLDTSLSDEGITLRKCDPNYRIWFPDHDHIDLSTDIPSMKEQIEAYEGPHGFERFLRFLVESGRHYTLSCEHILHRNFATIWSLVRWDLLLALPRLHVFESIYTRASRYFHSDKLRQAFTFASMYLGMSPFDAPATYSLLQYTEMTDGIWYPIGGFRTILDALVKISIRHNTAYILNTPVTSIALSDDHKHITGVHLSSGKFLPADIVIINADLTYAYNNLLPRTTYSESLQHKPTSCSSISFYWGLDTTLPSLQSHNIFLPPSSKYKSTFDAIFKNHQLPEHPSFYLHIPSRIDPSASPPNTDAIVVLVPVPHLSPTTSSSSSSPTSPLNPHNATAYWHTTTQTIRALILSTIHDLTGNNIEPHIACERIETPLTWKDKYNLDRGAILGLSHSFLNVLCFRPRIQHESIQGLFFVGASTHPGSGVPVVLGGSGVVVRVIEEWVGKVRRGDIGRGVRGVWVGVVVVVVVVVMMMRVEMGMRMGEWFCGLEEAWMESGDESTWRVLLCAILGIGLVRNLCLACTGVPAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRQ8</accession>
    <name>A0A8G1VRQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_501899</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520087.1">
        <property type="nucleotide sequence ID" value="XM_025664182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRQ8"/>
    <dbReference type="GeneID" id="37167584"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF27">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="36"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH62165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="514" mass="54866" checksum="CC564752093A3229" modified="2022-01-19" version="1">MSTTTTTVTSEISSLRLSAEEVRLPAPRDDRKSRLQQVVVITQLFAVTLTASVINGLVVVGLPTITADLQLPPSLSLWPSSVCSLATASTLLLSGSIADTIGPRWVELVGSLASGALMLGQGLSQTGIELVIMRAFQGVGLSMHLASSVSIVTQLLPPGKGRNLAFSCIGLSQPLGFSLGLVVGGILIDTIGWRAGWYIAGGITLFFTVIGLWSLPKSPVQRDGHILRNVRTKIDWVGAGLASAFMALLCYLLAILSANPSRIRSAESIIILCVAAIALPTFITWVHFQVKRGKPALIPNALWRNTSFSSICATVALSNAVINSMELFASLFFQEIQSLSALGASIRILPSLIVGVLINLVIGFFVHRIPAYWIVTITSFFCAFSPLLMAVINPAWTYWANAFVAQLLQPISADALFTVGLIVITNVFPDDTQALAGAVFNTSAQFGSALGMAVLQVISTVVTEEKEKGGESEKKALMEGYRASFWTMFGLMVVCTAVGFFGLRRSGRVGLKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VS95</accession>
    <name>A0A8G1VS95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_5521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520614.1">
        <property type="nucleotide sequence ID" value="XM_025665479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VS95"/>
    <dbReference type="GeneID" id="37168881"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH62692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="339" mass="36018" checksum="27CC9D5C95016964" modified="2022-01-19" version="1">MPAIKQFPTQLAHTLKTHNGPVNAVTFSSYPGTYVLTGSTDRAIHLSRAIPNNNNASAAETTSPIQKYEAHGYSVLDIAVAADNSRFASVGGDRQVFLWDVEQGGTIRRWSGHNARVEAVQFAGEDDSVVVSGSADTTINIWDTKSNSYKPIQTLTEARDTVSSLHVHMPTYSIASASYDGRVRVYDIRMGRTLVDVLAHPVTSVRCSNDGNALLASTTDGRIRMLDRSDGKLLKAFGGDEVSPSQGNSNATYRKSDLRIRSIFAKADAIVLSGSAADDSGNGNGATQASVFAWDVLSGEVIACVPAGPGVKAVSAVSWNEKGNCWAGGCSDGTVKVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSP0</accession>
    <name>A0A8G1VSP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein ROT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_465065</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ROT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521049.1">
        <property type="nucleotide sequence ID" value="XM_025662023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSP0"/>
    <dbReference type="GeneID" id="37165425"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF1">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017290">
        <property type="entry name" value="ROT1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034669733" description="Protein ROT1" evidence="11">
        <location>
            <begin position="18"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH63127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="236" mass="26225" checksum="4777211A2068CB3A" modified="2022-01-19" version="1">MMATCFLFGLLLTAVGASSHSASDLEGTWTTKSRQVVTGPGFYDPINDKFLEPNLTGISYSFNADGHYEEAYYRAIANPQDPSCPKGIMQWQHGTYTVNSDGSVDLTPIAVDGRQLLSDPCQSSTGTYTRYNQTEHFESFSVSVDSYHGVQRLDVKNFDGSPMHPMYLIYKPPQMLPTQTLNPISSSKSKRQVEGDTGPRFSIKNMVSRERIGDPNNWLWLGIFMTTLGGITLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VTW0</accession>
    <name>A0A8G1VTW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_129147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520150.1">
        <property type="nucleotide sequence ID" value="XM_025653977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VTW0"/>
    <dbReference type="GeneID" id="37157379"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="261"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="549" mass="66784" checksum="522D055246E4AB64" modified="2022-01-19" version="1">MYSSYPRGRHLLTDSESDFSESDYSMVETTPRRKVTTRRRSISRHRWSPEHIHSNTYLSPVIHDHHAPQRSASTGARRRPDRDRERERNNQPVAVIVDVHNKYDAKADAKTDAKSDAKNDARNKSATKNRKQEHKMQQNYIDPYESEDETRLRDHRRARTRPSSISREASPLPPTRDYELMLDTRFLERNDARQDLELLRHQQEIARLERELARHRETSQHRQQQQLQPQQPPPPPPAPEHEHRSPPSHHHHHELRLLREEDLYEDEISERLRRLERYEKKQRMEEEQREAEHRYQLIKFEEAQRKAAEQEELSQKMRQRKLEEIQRKMEEEEEKERIRKELRDEEARRILAEQERARKEAAMKQAAIEEWKLNEERRMIAEREERKRRDAEFKERLRLEFGYDEEQLEKIIKKEKEPEKPKEPEKPKEEPEKPKEPEKEKEKEKEKEPEPQRTTWIKVHRKHLLPDTLIAYRLPWDWDELDGNYIIIKQWISEDFQEELFAHSRRLREGKLVAQHSSTLTELKVNDRKKDKMYLVRKKNPGSRAWIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VUB3</accession>
    <name>A0A8G1VUB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_515303</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH62678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="195" mass="21693" checksum="CCBAE9D880BBD295" modified="2022-01-19" version="1">MGDHVLFFYGTLMAPPILHRVIHGHSTPEPWQKALLTIKPAILHGYRRHRVRYADYPGIIPTTPSSSSGADDTAAAAAGEASVLGTVVWGLTDGDVYRLDRFEGSEYEKKAVRVRVLNHQQQQGEGEHGTGEIQAVLGAAAETEGSGETKEGEEVEAVTYVWTAGKERLENAEWDFEAFKRDKMAWWVQADERDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VUV1</accession>
    <name>A0A8G1VUV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_494985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034137395" evidence="1">
        <location>
            <begin position="17"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="198" mass="20170" checksum="5FC48FDF0FFBEEC7" modified="2022-01-19" version="1">MKFTLLPALLSTSVLGLNIGRAQATAQVTFIGAAGAQFTQDFPTDGSNVKITNPLSISHISCSTQGAVCTFDGIDHSVTTVTGVGQVDVGPPQTQVQGSCRFKSGSTPSNPGQTQPTGGQVLITFVGAANAQFQQQFPINGVSTKISNPLSISHISSTTGGVKCTFNGIDNSVTTINGAQTVDVGPPQTQISGTCRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8G1QQB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_464557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH51693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="204" mass="23421" checksum="3E7797C93E12803B" modified="2022-01-19" version="1">MDKNVLYVTTGRLECAVTLMQPTDRTHCGGLPTFRPSGKYWRRWASKVGYNNMLTLRSRKLRLTIYLRHDGFCSRWVCHGDTGNRGLNARLSGATFLLFLNGYVSNTRLRAVKLACGVKIRRPFYWLLITWLCGTKAKKTPKSDAVGISPYPVYAQANLQSLHYDRKQQNTHAERMSMLTENTRMHDTSNVEESSRTRGRKTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQS4</accession>
    <name>A0A8G1QQS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_408985</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="RAH51872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509794.1">
        <property type="nucleotide sequence ID" value="XM_025657423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQS4"/>
    <dbReference type="GeneID" id="37160825"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002068">
        <property type="entry name" value="Polyadenylation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:003052">
        <property type="entry name" value="Polyadenylation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="182"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="266"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="379"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="476"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="570"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH51872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="606" mass="66895" checksum="7A1AB649036F0D39" modified="2022-01-19" version="1">MAFYDDPGNDAQPFGRPPKSYEGGIAGPRRPRLVTDYGSSMVQWIRTRKPRYKGGHQIEVERPSASYVVDMLPPLARVHSPADTIPVRHLHQSIGKSKKPITVVRWTPEGRRLLTGGHTGEFMLWNGTAFNFETVMDAHYDQLQAGVTSLAWSHSHDWLISGGQKGDVKYWRPNFNNVETIDDAHHDAVRDLAWSPSDTKFLSASDDTTLKIFDFTARTCDTVLTGHNWDVKSCDWHPTKGLLVSGSKDHQVKFWDPRTARCLTTLHSHKNTVTATRFSRVNNNLLATSSRDQTARVFDLRMMRDICILRGHEKPVSSLTWHPIHSSLISTGSEDGSLYHYLLDEPNLPSGQIPTIAPYDSNDPANTPAQVIYPAHKVQYAHGATIWSLDWHPLGHILASGSKDNFTRFWSRARPGETSYMKDRFHIGEEAAEAQGTWSRGFGRRQMREEEEQELQDEAESLVDQKKPAGMSSLPGIQFAPPGAAPQPDGMGSILPGIGAPQPPPQPGFSNSMPQMDPGRLAALLSSQPPPQPNNFPPTTGLPGFPMHPAMSGTPPVNVDLAELQKQLLSQGISLPQNFPPPNFPGMPGGLPGLQGSSTPDHGYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQT6</accession>
    <name>A0A8G1QQT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_464229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510045.1">
        <property type="nucleotide sequence ID" value="XM_025661974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQT6"/>
    <dbReference type="GeneID" id="37165376"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="169" mass="17913" checksum="DB4DFD878F6CABD3" modified="2022-01-19" version="1">MWPGHDKCQCGFGTPASFGMNSGEYAEAKIQARTSPPDLPGVYFGVVKGRSRRQQVSIGLTAASSPIDPNGLPTDGHIPHPLPLSVLNPTKCLPVFATSRGLSCALAGQGRQIAPAGVCLPPFIHPPSQYRSQPVKGVSMLVRGLSDAILIAIPLFLLTACICERQGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRP6</accession>
    <name>A0A8G1QRP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_454057</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825085">
        <property type="protein sequence ID" value="RAH52352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510274.1">
        <property type="nucleotide sequence ID" value="XM_025661190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRP6"/>
    <dbReference type="GeneID" id="37164592"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] cytochrome b small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH52352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="167" mass="18272" checksum="B595DBB3E8622784" modified="2022-01-19" version="1">MASIARQSSPLLRSAFRAPFATKNVAQVVAFHASAKKQILPPLPQTIQGTMNDPAPIPKSHPTEGSYHWTFERIVSAGLVPLCIAPFAAGSMSPVMDAVICSAIVVHSHIGFHASITDYFPTRRVPKTHTFMIWLLRAFTLSTAVGLYEFETNDVGVTEALRRVWNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRQ8</accession>
    <name>A0A8G1QRQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_204110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825085">
        <property type="protein sequence ID" value="RAH52389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510311.1">
        <property type="nucleotide sequence ID" value="XM_025654562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRQ8"/>
    <dbReference type="GeneID" id="37157964"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="111" mass="12837" checksum="408A79A0585CC053" modified="2022-01-19" version="1">MRLRRRPTESNSAQERDEKGTTGEENEDVLRQKRYLTDEPKTKKNQRKERDEGSSAEGSELGTRRRCLAEKSKGLSPADSAYQRSRVATNGYVTLGMEMSRRHQLFNILYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRV9</accession>
    <name>A0A8G1QRV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_239839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825093">
        <property type="protein sequence ID" value="RAH51781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509703.1">
        <property type="nucleotide sequence ID" value="XM_025654829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRV9"/>
    <dbReference type="GeneID" id="37158231"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH51781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="172" mass="19197" checksum="3CBE97D3EB585560" modified="2022-01-19" version="1">MASELAGRVSLPGVEVLCQFHQPDLSLPCHPHLSAACQTAFHTWNMKECGAYFECLKLHRRPRIGVTRNPCCFCLYFVFCISTIPLFCIFGPLGVFYLHDQQTVLDGISTPRITTLDTKSISRELISSPLLAKTMEGTGTSGQLIWLAGRFSSPKHNGRSYHRKLPPILFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSA0</accession>
    <name>A0A8G1QSA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_384919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825089">
        <property type="protein sequence ID" value="RAH52006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509928.1">
        <property type="nucleotide sequence ID" value="XM_025656566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSA0"/>
    <dbReference type="GeneID" id="37159968"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="194" mass="22040" checksum="BB5603FA291FD8FA" modified="2022-01-19" version="1">MAPFKGSISRREVQWVRLSSSCTYNKICYFRRTKSVVGLSHLISIIGQFLIVSAKNRYDKLQDQNVRGYPDARVDASNLLSSLTFGMCACTFLNVFLCLIIICDWFWPERKENLCIQWAWKLGSAAASLFQLAACVVITIIVATQGVQIHGVSADEQETIRSTWDWISLAYRKDGRTVAGLVFYWVGCLFLFWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTP5</accession>
    <name>A0A8G1QTP5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_504186</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511406.1">
        <property type="nucleotide sequence ID" value="XM_025664288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTP5"/>
    <dbReference type="GeneID" id="37167690"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF152">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="22"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH53484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="381" mass="42347" checksum="87052EEB1355502E" modified="2022-01-19" version="1">MGYNLTAEMFSEWAIGLVVIAVRLYTRFSVDRGMFRWDDVCLVLGTLFWTLLVVFLYLCTAVYGSNIGLNATTAAEVPDDQVPSLTKGSIYAFLAWLSYILMVWSFKGVLVFLYNRLTIGLSQHRLALAVGAFTMCTFVTSLLFDLLMCKPIEKNWQVKPYAGNNCTVRPLNYIVIEVLSILTDLCIMCVPIPLIIVAKIPTSQKWILTGLFSSGIFVMIAAALRAYYSVKDLSTLATALGWASRQAFVSAIIVCAPGIKPLLSRFSWFASYSSSRGYDKKDRSRTTFFNSKSGGRDVTMVSTCEPQPYELSSMGWSKKRQNLSGESQEHIMDSLPAPQQGYAGDSERNMGIVITTDVTLAHEEAPPEDLHNVSTTRPYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUE2</accession>
    <name>A0A8G1QUE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_443842</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825097">
        <property type="protein sequence ID" value="RAH51670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509592.1">
        <property type="nucleotide sequence ID" value="XM_025658888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUE2"/>
    <dbReference type="GeneID" id="37162290"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="13"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="552"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH51670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="672" mass="73603" checksum="A940C1DDB4C6393D" modified="2022-01-19" version="1">MSRPFPYTFISCPCANIPVPDPAKKRRSRESPQKSNPDQPKSLLRPDDDEDEQAFDPRSPRANFSLYPPEQLLYCEDCHQIKCPRCITEEIVCWYCPNCLFETPSSMVRSEGNRCARNCFNCPICTAPLGVNTLENVVTGGTSQQGPWVLSCGYCMWSTLDIGIKFDKPTNIRTQLSKMTEVTPARSRQMSRTFGDLKSPLSTYSSIDEQFLPPGETKPEDPPLDQPSAPLTPDARFHALKNFYKNQISATSSSPTDPLGMDFGSGFSSPGALNRIMSLYTSSSRLSSLYGGANKKPKTKPPVMREALTASEGLKIPSPDAEDTLIERMSSPDCGWDGLASIEQRVFQSPDARFVEDLLPLPVLLRTKRSKRCKSCKHILVKPELKPQSTRFRIRLIALSYIPLPTLRPLNPSPSPATTTTTTVLPAPSSSTTNPNLDALSPLRPIQLLLTLKNHMFDPVRVTLATPSVTPGRVASKVTILCPQFDIGANSDVWDEALQGTSATTTTATSTGTDPRGSRSGGLGVYEKVAEAGKVWDKGRNWTTVVLEVVPGTLPGGAKQTSANNTKKDKKKKKAPADDDPDDQDDNSDDGDSDSDPGFDWSGQTSDPNEQLQPDEDVLEIPVFVHMEWDSDNQIDSEQGVGRAGAGGSDTVKRELAYWMVLGVGRIVREIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUH9</accession>
    <name>A0A8G1QUH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_145824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511811.1">
        <property type="nucleotide sequence ID" value="XM_025654103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUH9"/>
    <dbReference type="GeneID" id="37157505"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034738437" description="REJ domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="17451" checksum="E1572DB5AEBCF3B2" modified="2022-01-19" version="1">MYLSKVLLFTGAAFAPFASAAVQAVPTETPVPVSSTQVASTPLAPTPTSISSSPLHTASSSIVISSSSSSARFHPSSSASPSHMASSSRRVSSSAISSSAIASSSASFTRSYITKASARPTTTTSTDADSKSKSNSGSDSESATAAAASATHSGAAAPVVQLSGGMAAGVLAAAGFIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUI5</accession>
    <name>A0A8G1QUI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_380797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511744.1">
        <property type="nucleotide sequence ID" value="XM_025656397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUI5"/>
    <dbReference type="GeneID" id="37159799"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="163" mass="18125" checksum="132BE42F2A4B219E" modified="2022-01-19" version="1">MSMPTPIPVTLNNPPNPQTREDIIDALDRAILGLDTADSRLFDSALFPDSTFDLHGTVMSGLPNIHKDCYDNISKMDTTHILSNIRVSMVEGDECKVKLTASALAQHYRPGEGKVNDTSRLLGGGLYYCDVEKDVAGDELWKLRNWVVKLTWTEGDWGLFKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUI9</accession>
    <name>A0A8G1QUI9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YjgF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_523202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511820.1">
        <property type="nucleotide sequence ID" value="XM_025665325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUI9"/>
    <dbReference type="GeneID" id="37168727"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="126" mass="13441" checksum="8C2F6015275E8B54" modified="2022-01-19" version="1">MSTGLDIVHTAGAAQPVGPYSQAIKVNGQIFLSGQIPLTKDGVLIEGSVTEKTRLCCENIKAVVEAAGSSVEKIFKVTVLLADMADFDEMNQEYGKFFAHKPARSCFAVKQLPKGVPVEIECIALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUM8</accession>
    <name>A0A8G1QUM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_148036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511886.1">
        <property type="nucleotide sequence ID" value="XM_025654122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUM8"/>
    <dbReference type="GeneID" id="37157524"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034285260" evidence="1">
        <location>
            <begin position="30"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="105" mass="11875" checksum="EDCD845D5976980A" modified="2022-01-19" version="1">MSHEGFDIRPDGRFLWSCFCLCFFVEVHSGREAFPERRVPDKCHDHAAPLVARHGVPQFTGFRINKVSVLSIEGPYDGSAWSLEASRIVNLKDINKVTLTQSTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUQ3</accession>
    <name>A0A8G1QUQ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_215243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825092">
        <property type="protein sequence ID" value="RAH51820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509742.1">
        <property type="nucleotide sequence ID" value="XM_025654641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUQ3"/>
    <dbReference type="GeneID" id="37158043"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="172"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH51820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="315" mass="34434" checksum="B5E4BF6E29F7EDC4" modified="2022-01-19" version="1">MPPPPPSKPPPLPTNHLTFDTWNSSSTGHQIADPGSSRGITSWRETRREKLTRQFGVGRGDCTYDSDGEKKGEWVVTTQIPAELQKKKENGRRNQQRDIRSMFGVSKPIPHSTTGISSSSLKRDATSLDNHEQEEKEKRIRIDHQDINGNKITDTDTYTESISRREINASTSTSTIFSSLSIHINGQTTPTVSDHKLKHLLISHGANLSLHMHRGVTHVILGEPNTPPSSSSINSGIKVAGAGGGLAAEKLQKEIQRGGWKGVKLVRVQWAMDSIAVGKRLSEAKYAAQLRTNQRSVLAFTTSSTATSNTISSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV25</accession>
    <name>A0A8G1QV25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_504240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511428.1">
        <property type="nucleotide sequence ID" value="XM_025664293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV25"/>
    <dbReference type="GeneID" id="37167695"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="519" mass="58187" checksum="543864AEE840F43F" modified="2022-01-19" version="1">MPASRPKRQDRPKHSELDTKRHAIRAGMERGESNVEETNESERETWAKANRHLLNQVSVFSEESLIDEVDEGRAGRYSCPPLMSADSEAFLSPEETTAMPRPAFYRQVLSRPSLVMRPMYPLTPDDSPEDELNPKAHNASKQLYQSLEQFTTGTTSSSSDLASSTNSNSQGHIKRCARHQRRSTPYSRPSRAPRPSRIHSPNAWLGRMQACLSEVDMEVIDQQTDLVGLRNCDLSHVIVSHREYPFREINFIMLVWKDVTGPLDVDWPALQVPLKNRLAASYHEQNDHGSRRALYGGIVVGQLAQFYVFVGEGPAQLNLSIFGDNKLTLNLEHDQRLIDGHLSWIDNEFPPKVYKEIENDPSIQAAACCIEDILGSVSSSSTVFDPLPESEIAPITDLSSTSAPLPQPEFVPEELSSTTFDAENSFEDFLNEVTWQVEEPENGQDEKDQGDNDDESDGIEESKTDEVADIIDEDTLIKKALKYVGEGALDTVVGSVCLTDELNFETDDEQGRYIKNELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVW6</accession>
    <name>A0A8G1QVW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Lysophospholipase</fullName>
            <ecNumber evidence="3 11">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_429062</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the release of fatty acids from lysophospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 11"/>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511739.1">
        <property type="nucleotide sequence ID" value="XM_025658235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVW6"/>
    <dbReference type="GeneID" id="37161637"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7 10 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034553886" description="Lysophospholipase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="13">
        <location>
            <begin position="54"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH53817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="628" mass="67358" checksum="63B29ED7B804DD3C" modified="2022-01-19" version="1">MKTSALLGSVALAFLPSTSAAPSQINNRRARADTSVERRASSSATNPYAPVHVSCPATRPSIRGGATLSPEEVSWLDTRREKSLSGLKEFFDHVEIDCFDALDYLDTSDSSSLPNVAIAISGGGMRAMLNGAGALKAFDSRTEGTAAQGQLGGLLQSATYVSALSGGSWLLSSVFMNNFTTISALQDTFWDFSSASILEGPASMEPTDFWGNITAQVKAKRAAGFTTTDADIWGRAEGYYFLNASHGGVDIHWSSITKTQAFQHGDMPLPLVVVDGQSFADANDEPGEDKPIYEISPWEFGTYDNNMYGFAPLEYLGTRFVNGQVPENDTCVRGFDSAGFITGTSSDIWNENGADIAATLRAAIGDVSTNTTEGALEVELLSYILEEVMGAVSSNNTATSGPAAYEPNPFYGYNTNTSPFAETTRLTVVDGGEDEENIPLNPLIQRKRDVDVIFAIDSNNNDAGYKWPTGESLIATYERTLAGYANDTSFPSIPDGNTFVNLGLISHPTFFGCNSSNMTTPAPLIVYLPNHPVTYMSNTTTTDTTFNTTARDAMITNGYNVATQANGTLDNEWTTCVGCAVLSRSFDRTNTPVPAACEQCFQRYCWNGTLDTSTPAVYDPSVIFPSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QW39</accession>
    <name>A0A8G1QW39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongator complex protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_452148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512645.1">
        <property type="nucleotide sequence ID" value="XM_025660756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QW39"/>
    <dbReference type="GeneID" id="37164158"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH54723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="37961" checksum="1CD59E7D0CF03CC2" modified="2022-01-19" version="1">MPSQPPLPPLLTPYVSSLPPSSLTVLSSVLGATGNWLVLRFLYAALNSSSTSDAVAGLSDTNNGRKRKVVLVSFLRGWEFWRSEAKRLGLDLARLTDKRQFAFVDGLSELFAAPSATSTQTPTIQPSPRGTVPPRTVLPLRSQPGPVPARGPQPAARPVAAPPNPPPSREVGPVKRLHLSGNGNAALDMLEKDIAAVINDLKTSTSGDEQEEPEVLLIIDQPDLLLAATGPSRGIGATEMGDWVMGLQQYAHATIMTVSSDSPLIHNASASAHQGATPLETEHAAFAIGSAHRAHMVMQLRNLETGAARDVSGVLRVSKGGAWGQNDSTEANTHWEEKEVLYFVQRDGGVSVFGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWM9</accession>
    <name>A0A8G1QWM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxyphosphonoenolpyruvate phosphonomutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_431145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510657.1">
        <property type="nucleotide sequence ID" value="XM_025658325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWM9"/>
    <dbReference type="GeneID" id="37161727"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF16">
        <property type="entry name" value="CARBOXYPHOSPHONOENOLPYRUVATE PHOSPHONOMUTASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="264" mass="27542" checksum="D5D317442FD20ABD" modified="2022-01-19" version="1">MSSQNDRAIYFRSLHHPGNPIVLSNVYDGATASYIAGHATTKAIATASYAVAASQGIADESLTLPQNLAAARTIAAVVAATTSPQLPLTVDMQDGYEDVAQTIRDVIALGAVGCNLEDFDNAAGKLRSLPEAVNRIRTAVQAAREAGVPDFVINARTDVLGPAGTGSIEDAIERGKAFLDAGACTVFVWGPGGRGVSGDEVRELAKALGGMVNVKLKLGDGYLTVSELKKIGVARISLGPELWRAAMGAFRETADRLLAQVSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWZ3</accession>
    <name>A0A8G1QWZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyamine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_379826</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512056.1">
        <property type="nucleotide sequence ID" value="XM_025656357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWZ3"/>
    <dbReference type="GeneID" id="37159759"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH54134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="459" mass="50769" checksum="665E09EE953EE4A6" modified="2022-01-19" version="1">MAGFAGTALDLANQLAMKDQAKNWNKELIDITYTISASIAGIAYGPLLINPVAQALGRTAIIFWCLVFAMACAIWSACMTSRGDYERFVASRLFDGIFGSIPSIVGVGAVYDMFFLHERGKAYAIFHVSFLFGTVAGPTFGGFIVQHTDWPWVFWWIVIAQGVVLILAFLFLEETSYSRDGKTLSAVKPKNFWVNRMATLLPHKTGISRAELGRIARLPFRIGLSPVGLLIGIFQLASFGWFVATHSLLTVWLEKPVSVGGWGFSPQRNALFIFSLWVGLLTAELWGYLCNDRIALWICRTREKGVWKPECRLHALWIPSLIVLPIGLGIVGSALQYHLHYMVLALGAYLITFASMSSVPVAVTYMIECVASQPTEVGAFMGAYRLTLGLVVPFFINQWVARVGFGWVYGMMAFFSIFAFGFVVVLMLFGASLRERTLAKFAPSEIGAKVVYISHEDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX25</accession>
    <name>A0A8G1QX25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_452541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512101.1">
        <property type="nucleotide sequence ID" value="XM_025660843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX25"/>
    <dbReference type="GeneID" id="37164245"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="243" mass="28141" checksum="623DE5BDFACFCE0F" modified="2022-01-19" version="1">MLDTTQTPVDGVIVVGRLKFERPDWLINELPDWRHAIYTRDDRRHPLSIPKNKGKASTVYLQYIIDHYHHLPATIVFLHNHRKPGHTEFRDYGNVAAVTFLRREFVQKNGFANLRCTTTSSSGSSSNDECGNVIRPVFDANETSAQVTTIEQEYPVILKTVFNSTNVPEKIATPYCGQFAVSREQVHKRPREEYMRYQQWVMETKLKDEEIEQVMGSLWHVIFGREAVYCPDTAKCFEDVYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXB3</accession>
    <name>A0A8G1QXB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_479576</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10234"/>
            <dbReference type="Rhea" id="RHEA-COMP:10236"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8 9 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513525.1">
        <property type="nucleotide sequence ID" value="XM_025662957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXB3"/>
    <dbReference type="GeneID" id="37166359"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052909">
        <property type="term" value="F:18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000007">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="12">
        <location>
            <begin position="48"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH55603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="387" mass="43604" checksum="61508418D0C294B0" modified="2022-01-19" version="1">MPKVKQQKRNSASKASPYADAAAKTKAANTVFKMNTDLGQHILKNPGVAQRIVDKAELKQSDVVLEIGPGTGNLTVKILEQAKKVIAVELDPRMAAEVTKRVQGTPAQKRLDVILGDVIKTDLPYFDVCISNTPYQISSPLTFKLLATSPAPRICVLMFQREFALRLFAKPGDKLYSRLSVNAQMWAKIDHIMKVGKNNFKPPPLVESSVVRLVPKNPRPQINYDEWDGLLRILFVRKNKTIRSSFLGKSTVMDMLEANYRTWCAQNDIPVEDGPAEGAESDAMDIGNAQDEEDDEGEDEPDEGMDVDDEDDVPDFFKEQTNARIQEALKNRPSRKKKGKVAELVREKVRQVLEDETRLADKRARMCDENDFLKLLWAFNQKGFHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXU5</accession>
    <name>A0A8G1QXU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_405872</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511257.1">
        <property type="nucleotide sequence ID" value="XM_025657316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXU5"/>
    <dbReference type="GeneID" id="37160718"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF53">
        <property type="entry name" value="TMEM14 PROTEIN HOMOLOG YJR085C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH53335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="108" mass="11533" checksum="DBC4E136D947C3E1" modified="2022-01-19" version="1">MAEHPSFTLACLLPVGGIAGYMRTRSAPSLIAGVGLGLSYAYAGYLIKENKDYGTELALGNSVVLLVSGLMRTIKTRAKAPIPMALGATGLLASFYYQKKVREFRFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXY1</accession>
    <name>A0A8G1QXY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_140897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512117.1">
        <property type="nucleotide sequence ID" value="XM_025654073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXY1"/>
    <dbReference type="GeneID" id="37157475"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="3">
        <location>
            <begin position="37"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH54195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="383" mass="42165" checksum="900D64B0F067C7DA" modified="2022-01-19" version="1">MTASGKPLVVTDESHHAGIVIVVGTLALIMTLICLAIRVYVRTILSPGFGRDDYLLFVATSFAIIQTSLVMSNSAKGFGTSISLLSSDQVVNVQRTMATTDTLFLITAFLSKCCVLGMLSRLTPQRIHHFILYAILGLSICWVLSSVLIILVNCELNKPWARPIDHCTGLFQKWEYIGATDSIIELMLFLFSILLVKSLQMPTSRKIIVLSSFAVRLPLIIFTSLHLYHLKNYAYSTNPTLDIIDSYVWTQMGMNYSLIVCTSFCLAPFMRAISVTYGNAGEVTLGTSSARSKSGKYARDVSKQQSQSYALQSMDNQDEAGHGLNNPRRSQPTFVPEQSAGIFNATVSDGCSRRTDGDSVASSESTKMIIKKDVEVTITHEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXZ9</accession>
    <name>A0A8G1QXZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome regulatory particle subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_480610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512147.1">
        <property type="nucleotide sequence ID" value="XM_025663017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXZ9"/>
    <dbReference type="GeneID" id="37166419"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="74"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH54225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="278" mass="30933" checksum="2186BBEA1B47BE4D" modified="2022-01-19" version="1">MANDLKVIVSELHSALGRQQFEAVNDLLSRGKRALLLQNVLIPTPSAPAELVAQAREVLELGAIASIRQTDAPTFTRYYQQLQPFYDLERDSTNAGHVDIRNSQRSKITGLYLLLLLSMGDSTSFHTVLEGLVEEASLKGKSVEDDPFIKYPVELERNLMEGSYDKVWRETNSERVPSEDFALFSNVLVGTIRSEIADCSEKAYPSLPISNAKNLLFLESEGAVIEFAQQRGWVLRDGRIFFPVEPEAAARSEKDILVASGTIIENAIGYARELETIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY50</accession>
    <name>A0A8G1QY50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein S13p/S18e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_479225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513634.1">
        <property type="nucleotide sequence ID" value="XM_025662939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QY50"/>
    <dbReference type="GeneID" id="37166341"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003140">
        <property type="entry name" value="PRK04053.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH55712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="155" mass="17900" checksum="64CA25B4BE6FEBEE" modified="2022-01-19" version="1">MSLVSGEKTNFQYILRLLNTNVDGKQKIMYALTQIKGVGRRYSNLVCKKADVDLSKRAGELTTEELERIVTILQAPTQYKIPTWFLNRQRDITDGKDSQVVSNSLDSKIREDLERLKKIRSHRGLRHYWGLRVRGQHTKTTGRRGRTVGVSKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYV3</accession>
    <name>A0A8G1QYV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_452975</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511752.1">
        <property type="nucleotide sequence ID" value="XM_025660961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYV3"/>
    <dbReference type="GeneID" id="37164363"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="59"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH53830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="507" mass="55364" checksum="357428E073E1E6A8" modified="2022-01-19" version="1">MTQRDEKEQSASGSSSPLETMERRPDVGSSTFNAIVVDWNGPDDPECPRHWPKSRKWLNVLLISLQGTLSPIASTILTLGVFDIATEFRLTSPYTPALPIAFYLVGLALGPLGVAPCSEIFGRRPIYTICFAIFTLLNIGCALVHNMAGLVVLRFLAGVAGSAGPSLGGSSIGDLFSHEERGKAQAVYGLGPICGPVLGGVLGGFIAYGTHGWRWMMWVVAIAAGVVTSLAVLFQKETYAPVLLQRRKRALEKANPGVTYRFEVGSHASQVFRQSILRPLRLLFFSPICTFMSLYLALVFGLLYLHMVTITLLFASQPKYNLHSYNWTHGTTGLAFLGAGLGAFAGVAFCMKYSNPSYRYFATRYEQKTGKATRMPEFRLPFMQVGMLIVPIGLLIFGWTAEYHVHWIVTLVGAAILGLGMVTAYICVQSYLVDAFEVYAASALAAAVVARFIVAAVFSVVGFQLYRRLGYGWGSTLLAFICLVAVPIPFLLGRYGPRLRRMGTEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ15</accession>
    <name>A0A8G1QZ15_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_461394</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513151.1">
        <property type="nucleotide sequence ID" value="XM_025661782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ15"/>
    <dbReference type="GeneID" id="37165184"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH55229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="325" mass="36013" checksum="0315CDC816C8B429" modified="2022-01-19" version="1">MVKVAIAGGSGGVGREVIDALIAANKHKIIVLTRKSMQDTLAQEPTEGITWIKVDYNDTTQLIKALQEVHTVLSFITTQDDPGSTTQKNLINAAVQAGVKRFAPSEWASSRLDYLDWYAYKGETRRYLQELNKDKKVLEYTLFQPGVFVNYLTHPHQSARHLPSIATPFDFANRRMILVDGDDGTRITLTAVQDIARVVARAVEYEGEWPVVGGIQGFNISIGEFIALGERARGGLPFTIERVKAEDLEAGTWETSWTPTVDHPSIPPEQVAVASKYMTSRILLAVNAGSYAVSDEWNSLLSDFEFTPVEKFLTEAWKGKARVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ39</accession>
    <name>A0A8G1QZ39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SsDNA binding protein Ssb3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_450937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514205.1">
        <property type="nucleotide sequence ID" value="XM_025660488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ39"/>
    <dbReference type="GeneID" id="37163890"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000271">
        <property type="entry name" value="Similar to ssDNA binding protein Ssb3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH56283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="122" mass="13200" checksum="009DB9EF15936F8A" modified="2022-01-19" version="1">MSLQTPRILPSHLHAFHPSSTGPRTSHTVRILGTVTALRGDTATMTCGNHGDVTLILKPDSHLQMGKLVEIIGKVADLDNGSGVGIRVLGSTDWGSPADCDYKIYEHVVNATHKLKPIFYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZF3</accession>
    <name>A0A8G1QZF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_423208</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514309.1">
        <property type="nucleotide sequence ID" value="XM_025658004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZF3"/>
    <dbReference type="GeneID" id="37161406"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH56387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="516" mass="58260" checksum="F02DC8C9CE80051D" modified="2022-01-19" version="1">MSTLLFVATASPILYLLYVLLSRWQHAQNARKWNCGSIPSYPGDVLGINTLKEALAMDKARQVPTVTRRRVDIMSARENRYTTTFHFRQLGTDVISTCDPKNVQALLATQFKDFELGQSRRNALHWLLGSGIFTADGDHWSRSRALLRPQFTRDQISDLDLEERHVQVAMRAMPVDATTGWTAATDIQTIFFRLTMDTATEFLFGESVQSQAAALSNGAMPQDDFPAQFDRGQWYSAQRARFEKLYWIVNNKESRAINKAVHAYVDRFVSAALNSDPEKKPTGHYVFLHGLAEATRDPVELRSQLLNILLAGRDTTASLLSWCILFLARHPDYFNSLRATILAEFGSYSAPHDITFANLKSCRPLQNFLNEVLRLYPIVPGNRRTAVRNTTLPTGGGPAGTDPVYVKKGQPVFYSTYVMHRRPDLWGADADEFRPDRWNERKAGWEYLPFNGGPRICIGQQFALTETGYVLVRLLQRFDVIEGVGKTKEGEITMQMSLTNAPGDNVTVRLHEDASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZI6</accession>
    <name>A0A8G1QZI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lignostilbene dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_375729</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513674.1">
        <property type="nucleotide sequence ID" value="XM_025656187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZI6"/>
    <dbReference type="GeneID" id="37159589"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH55752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="499" mass="56782" checksum="DDD8173E5B80A36D" modified="2022-01-19" version="1">MAPSQMIPQHFPSLPQFSHFMKPSRFEGETNYLEVIGTIPPEVRGTFYRVMPDPHLPSRVKDDPWFNGDGNVSAFRFESGKVHFKQRYVRTEKFIKECESGRALLGKYKNKFTDAIEFTVRTTANTNIVFFNGKLLACKEDALPYEMDPVTLETIGLYDFNGQLPSLTFTAHPKLDPVTKEFIGFGYEAKGDGTPDICYFSVDPLGNFTDLVWLVSPVVAMIHDFAVTENYAIVLFPLIPHTCDLERMEAGGEHWQWTPNIPLYIGVLPRRGAKGSDIKWFRAPNAFPGHTSNAFEKNGKIFFDLPVGKKNVFFWWPDSQGNAPSPQEVACHLSRFIIDPSSDNLELQSAEILSSEDVEFPRIDERFLSREHNHAFFCLNDDTAPTIWPTVVAKMDGGHPVYNSIGRLNLRTRQFDKYFPGNKHLVQETVFIPRSSGAAEGEGYLLFLVNNYETMLSELHLVDTDNFTRPLAVILLPLRLRQGLHGNWVDDEDLKLARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZK9</accession>
    <name>A0A8G1QZK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_452588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512142.1">
        <property type="nucleotide sequence ID" value="XM_025660856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZK9"/>
    <dbReference type="GeneID" id="37164258"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH54220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="330" mass="35403" checksum="C8FDC1F351814E99" modified="2022-01-19" version="1">MGAQFSQLFPPRPTFTPDDIPQQLGKVVLITGGASGIGFEVAKVLYRKGAKVYIAGRSESAAQAAIQAIQKSVPATTKCSPGELRFLELHLDDLSTIKATASTFNSKESKLDLLFNNAGVSQPPLGSVSKQGIELQLATNCLGPFLLTQLLTPLLEAAALSDSGLTTPGSVRVIWTSSQVSELSAPPEGIIMSELTNPPKDAVRNYVTSKLGNWFLSTEMARRYGEKGIVSVAQNPGGANTNLLRNARWMKILSWPLLHSPALAAHTVLYAGLSGDLGLENNGAYVVPWGRIHDAVAPGLLDAMRSKTEGGTGRACEFWEFCEERTRDYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0H8</accession>
    <name>A0A8G1R0H8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_488477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH56988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514910.1">
        <property type="nucleotide sequence ID" value="XM_025663535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0H8"/>
    <dbReference type="GeneID" id="37166937"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16568">
        <property type="entry name" value="RING-HC_ScPSH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="351"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="394"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH56988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="474" mass="52892" checksum="DB5FFE9540333686" modified="2022-01-19" version="1">MSEPTPAGAALSNGSESTSTPNVNTGDNASGLFETLQSHVDDIRSLLQCGVCIRPLYEPYTLACGHTFCYSCLTSWFVGGRHNKTCPDCRAPVKAQPAPAYLVRAVVQMFTSRPELLDKGETTVEHLNHQREEAERLEKDKTNTHPREGGLFRGTFNKKIPVAQPIVDLEDNVVRCPRCSWELEEDEGCAQCGYRQDDESVTGSSGWSESDENSEMTDYLDEDDEIEDGFGDADEYGWDPNHDHLPLDIQPADIDQLYRQWYGLAPGDLPGMRANGPFRRQNHYDWPSGISSAHEEDSDMDEEDEDADMDSFIDDDLEHDDYSESDRSTVVGRHEISITHTIGTDLSTFDEMSEESLDEESLDDESHDDEDDDDDDDDEDPILPPAGGMRRNRIQTYRIQSSSPSCENGTSGTVSGRSESRSQAGSRNDRRLPQQVSAGSTVMDAISVDDDSDEGPVRPTRRTRDRGHRRPSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0V1</accession>
    <name>A0A8G1R0V1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_488580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515014.1">
        <property type="nucleotide sequence ID" value="XM_025663543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0V1"/>
    <dbReference type="GeneID" id="37166945"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034362683" evidence="3">
        <location>
            <begin position="19"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="115"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH57092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="538" mass="58946" checksum="DF1FA00247186690" modified="2022-01-19" version="1">MAGKLSYALVSLLPIASASTGLSCRCFPGDVCWPSTQDWDVFNATLGGRLIATVPAASVCHYNSTFLPYNAAACEELLAVWNETKTHYETSYSPMAPWFANFSCDPYLPNTPCTIKPLVRYAVNASSAQDYQTTIEFATKHNIRLVVRNTGHDYLGRSTGAGALALWTHHLKDIEIVEYQSTSYSGPAIKVGAGVQILDAMNAAHEQGYTLVGGNCQTVGYAGSGVDVITATGDHLVATPFNNSDLYWAMSGGGGGTYAVALSMTSKLYTDIPAAIANLTFTNDRVTQDMFWEVAASYIQDTTRLADLGGAAVWEVTNAVFKSMPFTLPGGTKEQLQALMQPTLDLLRSNNMTYTYSIASCSSFYECYTRFSPWMAVTEFQIGGRLIPRSTVDDELRPLVESFRTITDYGAVVAGVSFNASRSTIPDNSVNPAWRDALIRIVLGTSFDYYNYTHDVENQKLMTETLLPLLENLTPGSGAYLNEADFNQPNWQSTFYGDNYAKLSSIKNKYDPNHTFYALKAVGSEEWAEQTDGRLCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0X4</accession>
    <name>A0A8G1R0X4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_470100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513677.1">
        <property type="nucleotide sequence ID" value="XM_025662369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0X4"/>
    <dbReference type="GeneID" id="37165771"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF190">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH55755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="462" mass="52108" checksum="91C091BADB223DD1" modified="2022-01-19" version="1">MSLCTSIVILAVFVLLAHYVVRLMLDSVSHTRGIPGPLWSRLTNVWYLRQMIKGDFHNTNIKLHRQKVRIAPNYYSLSDPACLKTIYGLGTKYVKSSWYDAWNTEEDLTWTNLFSERDPKKHAANRRKVASMYSMTTLTSYEPFVDSCISLFRRHLDQAGSSASAVNLAHWVQCYAFDVIGYITFGERFGFLDDMLDVSNIIKSLDAAGSAASYIGLFIMLRPLIMKILRLMGLLRTVALADFAERNVKMGGSRKAIYGAEKIAFYSPMLNKLLEAKKAAPGRFTEWDIMANVISNVGAGSDTTAISLSAVFYFIYSYPETLQRLRDELEVAGIDGIPRFSDTQKLPYFQAVLKECLRLHPGTGFPMFREVPDGGAVISGQFFPSKVEKALMEQSYMPFGMGSRTCVEKNISLLEMNKLIPLVVREYDVEILGQGQGLKTCNHWFVKPVDFMVRISKRTNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0Z5</accession>
    <name>A0A8G1R0Z5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_397387</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515306.1">
        <property type="nucleotide sequence ID" value="XM_025657020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0Z5"/>
    <dbReference type="GeneID" id="37160422"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH57384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="549" mass="60921" checksum="935DB08AE743DF66" modified="2022-01-19" version="1">MERSENIASQACVACKRQKRRCDKRLPQCSLCLRTSRTCDYADTPKPPPTAADLENLQARLTELEERLGSITEQDSLSATAGISSSSSLATEPIGPNREPTSFPSALFLDIDCYKWSNMQLPRPAANIPMDILSILNQPNFVMDTTSLYFDTIHPWVPIISKKRLDLGISLKDGGPDIALLFLAMKLITLPPPPAPKITSKLYSSAKGFLATLEASGAVSFIYLQAMTLIALYEYSHSIYPAAWMTVGACARLTELLGITPGKDTMKIMSPAMTWTELEERRRVWWAIYILDRTISLGSRRRFCLPEPADTDVLPVDDDAWDLGDVANIIYYQVTTPLLTPMSPFSRLCQSAMFISRVAAHRSDSPAGLADHITSVLSLTEDLNTFSFIVAEEMDSSPTNGYIRLLAPRCLTWSALFLLLDNYCCPEKLSNEPGYTTSGDVKGPDELAAQVQATLVVRNISNQAHRTTTDIMDFVSNQRNDQMGRLSPLLLDALYCSMVTFQWVYREGADEEAKGLLADVEACMGRLSQRWKLASEYLALNEVYRGAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1K4</accession>
    <name>A0A8G1R1K4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_451580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513162.1">
        <property type="nucleotide sequence ID" value="XM_025660619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1K4"/>
    <dbReference type="GeneID" id="37164021"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF223">
        <property type="entry name" value="CYTOCHROME P450-DIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH55240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="536" mass="61589" checksum="A0B2D853A98FCB8A" modified="2022-01-19" version="1">MRLRTALAILAGIYLLYKLLSFIRFYIIGRRSGYPLVVTPLFTRHSLWQIVGPTFQVQLKRYFPTWLYEHLDIHIHGWEFRHKNAMHRRYGKIFVIVSPDECSLWIADPTVGATVLQRRKDFDQPDVVAKFMGFFGPTLIQSNGEDWKRQRRIIAPQLNEAIMGEVWEEACRQARAMLEYLLQHPGGETLTGLRSIAINVLGQAGYGQNQPWSPDFVETLGQDWQDARVSYFKTIAMVTDRFVEAVLIPNSLKVMPFMPESIRQLGRQMLKVPEYVREILGEERNTKSSEVPKKRHNLLDMLVRYAQHGTESSAKLFLSEAEISGNLFLFTAAGFDTTANTMGYAVMFLAQYPQWQDWVREELSQLDADVSSWGYDVFAQCPRMLAVMYETLRLFTPVLHSTRCVATTQQIADADGTHVLMPPMDVFISQQSIHRDPNVWGTDVDEFRPTRWIDDAGQVVTPAKGTFIPWSGGPRICPGMKMSEVEFVGTMATLFRHARCEPMQKGKLQQQMEDSISKLTLQVRELREVQLRWVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2L8</accession>
    <name>A0A8G1R2L8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_520141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515294.1">
        <property type="nucleotide sequence ID" value="XM_025665105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2L8"/>
    <dbReference type="GeneID" id="37168507"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH57372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="695" mass="77992" checksum="0A991955B6B7B3EE" modified="2022-01-19" version="1">MDRPSKRPRLSMACNICRQRKVKCDAEYPKCRNCRLRNQQCITTDPQRPGVTGIREWLDIPDKQTPQNDDQPQHPAVGDSNHQEATDSPQKLSPNEVSPVHHPFDVSFNVEHGTDKVKIMGGSSSQCLAKSLDVYFKAARLKPVSGCFRYGMRHAEELDLPLSLSLPELPDSDRRERYLSAYITRIHTLYPIFNTTRLRMGTDLFATAGGFTNLPREQIPRIVSAYLIMSLGADEIGQGATVDGDRYLQAAACLLSHVIIIPYLPTVQTLLLFTMAYRGRNQEGLAWQTLGMAIRTAYTLGINRTSTSNFEGKNIERRVWAVCWCLEKMMHLESGRPTVIGYQHPKPEDALGESKFLKWHVELGEYQGNISHHLYSHQSGTRDVRQILLDTARLDRELLSWANRVPTDLRPGSDIFCADEEFHAAAFLSIQYHSTLISLHRAALIAPTSSFEEEVAKYCSDEPSQFRMRHGESICVGSARAIAKLSVQLSERKTDSQTIPAGPSLLACIVLAIFLIKHPGSRLQAMDLQLLKACLEYSSQHLSRYDPDPRFIEGIAAIYEQCNTHLRSWSAAEAKRRPHSRDSLTKLNPLPTPAVDEALPPWRPTEVMQPSNLHKQSNGGYQSQRVIQSAVSTPAIDHGQDHLDSLGFSSTSMLDGFVAEGVNVDQVFPFEGYNVEELWNWMGCLDSPGSMPDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2Q2</accession>
    <name>A0A8G1R2Q2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nonribosomal peptide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_513753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516004.1">
        <property type="nucleotide sequence ID" value="XM_025664719.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37168121"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000012">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="784"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1818"/>
            <end position="1894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH58082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2360" mass="260079" checksum="C8D1EC53FE4FD000" modified="2022-01-19" version="1">MISYYEIQDAHPVSPPTYQSLKGHEQISQQPIQDPELAAEYWTDLFSHVGAQPQLHSFPLDHQWPRSETTIRAPEHLLEAALDFSERYSIRLDDLIYGIWALVSIRHTAGGHRTAIFTVAGRDRSFFGPECTQQELEDQEDFPLVLSVPEDMEALSWIRHVGAASAEAATHSHLGYKQILTQTGAAPPQVKVSIIPDDSEEVMTTDADFPLVLNLSASSGLKLSMRHNLAVPRTNVRVLLDHFAATLQQVVEKPSVNIAAVSLTSPAERQLLHEYGKAAIRSRRGLVHALVEKQARLRPDAHAVQFELDAPLPYGTLNKRANQLARLLRSYGATYIPVHMRTSTDFIVALLAVLKAGAAYVILDPDAPASRKSFIVEDVQADFVLVDSDTAGEFPREHKVRDLLSESMGNDNSDLSLDKDVSSLAYVIYTSGSTGKPKAVLLEHQAAYNGLLAFPKMLDLRQLLFFNPVFSAAQRSMWATLSVGGCLCLASKANLTVHLARTINSMHITSVDMTSTTASLLSPDNVPSLRRMVLGGELVNPAVVQTWSHRVELLSSYGLSECTQLNWRYRLQDTQSSSRIIGQPFDTTTSYILVPGTTSLSPLLIPGELCLGGAQLARGYLNNPEETARRFIPNPFGQGKLYRTGDLAVRHADGSIEMIGRIDFQVKINGQRVDPAEPNAVIQSYEEVKQSAVVPAAVGGKTALVGVVVSRADGDWDSLVANLRTYLASRVPRYMVPAFWVPLAALPTNANGKVDMAAIRAIVEDFAKSGQLLPDRPKNGTNGVVWTEKEMIVRALWARFLSFAEEDISVEDSFVALGGTSLEAIQVVSQLQTEHGLILRVEDIILGQSLAQVAGLIQSGGTAVNGHAPFTLLRETPSFERFGINTVDVEDAFPVTPFQEAIIANTMLGGTKYIYSRSYSFTGHSAGAVKRALTSLMDREIFLRSTFIPDGVSFMQVVRKAAPVPWETPSMDVKSYMQEQIQKPMHAGSLWWRAAALPNNVLVITIHHALFDYWSSEFLPQDLSSLLTGSAPVQRPLFSQYVKHLQQHDEPTMQTFWKKYLDGAVPTRLGAQTEQQTLVSASLTVDMKSTASALKVTPSMLLYAAWSLVLARATSSPDVVVGVTLSGREAPIPGILQMSGPTLMIAPLRVKVNQNSSFEEHLASVQASLWDVARHAQYGLRKILKVSRQPKDLFDTTVNFLIKVDNMPTTARGLTILPEKNYGTHDYIKLELSNEDLGRVTLSSMLEDGYARVLVQSVADILKVAAEAPDTKVAGLELVRDGVVNGVEREVDGPVEVAKTSPADDELGHSAFHRIACNYPSRTAVEDATGASITYAGMAIKVNQLAGLLRAKGVVLEQVVPLLLEKSISTIIAMLGVMVSGGAFLPLGPENPRERNLGIMEDCEAKVVITDRQSAGFFDDLMYDVIVIDDLDWDAMPIQREIVPDLTPDNLAYLIYTSGSTGKPKGTLLTHRALATAVEGIIESTEMDNSHRILWALNYTFDGSFFSLFSALATGCTLCVAPQSTIVGNLAGLINAMQVTAVCVTPTMAGLFHPDDVPTLQILATGGEPVTPHMQTVWAPRITVHSAYGPTEATICVTTTHVTPDMNLRNIGRPYRNVTAQILDPDTLQPVPAGEVGELCLAGPQLARGYLKRPDATDKVFRHRPDGIIYQTGDLARWLPSGDIELFGRKDDQVKINGYRIELGEIESVIMQTGLFSQCAVIAATVLKKKQLVAFCSTSAPGSREVVLLAPEQAPILDEIKDHLTTLPKYMVPSIWLPLSDFPLMGSGKIDRKRLLALAQDLADDELKAYLPAEEISAITSPAEHKLQHLWSKLFDTPADDIHANSTFHALGGDSISALNLVSLLRQDGYQVRVNDILSSRTLRDQAALLIEEPAAVATPPTASVVPAFQPTETMYNQLAQLGISRFEVEDIYPLSPGQIEFLTQGNKPEQFWQLMTVRRLPLDFDFSRWITLTTQLTQYNQILRALYLYADESRDPRTAVQVILRDATLNLTYHTYTTEEEKQSLIDSNWERRFDPARPFVRYALLTDATTGAKDLVIKLDHASYDGTLLHIFDDQFLALARNEPIPECTPFKEYINYITSLPKQPQLDYWTNLLKPYHNDTTTTPYLSTLQNPSLNNITTYPIPADMGIDALATTHNVTPSVIFQTAFSLLLSHLNTSSHGQKQSIVYDTLITARNVPIPNPQSITGTCANFLPFLSTIDKSQSIKSLLQDTQRDFWTSADHAAVSLSEIYEALEVDRDVEGAKALFCFQPFEKKFDGKEEDAMRWIVMKMSKNTMKFNYGVQLEVGKGAERGSYVVRFYWDGRVFDQQGARRAVELYGRVLGGLGRENIGDLDVEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3D3</accession>
    <name>A0A8G1R3D3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 20">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="5 20">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BO85DRAFT_371388</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 20">E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 20">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17 20">Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the RAD18 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 20"/>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515838.1">
        <property type="nucleotide sequence ID" value="XM_025656000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3D3"/>
    <dbReference type="GeneID" id="37159402"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000172">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004580">
        <property type="entry name" value="Rad18_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00599">
        <property type="entry name" value="rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 19 20" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 20" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 18 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ4-type" evidence="24">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="23">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU368093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RAH57916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="421" mass="46755" checksum="EDCD8EA590B13BE8" modified="2022-01-19" version="1">MDQTFDLPDSTDWLPTPLSLVAPLESALRCQVCKDFFDNPVITSCSHTFCSLCIRRCLSTEGKCPACRSSDQELKLRRNWAVQELVEAFQNARPSVIDLARKAAARGSATEEAESEEPAPKKRKVEAVDGPAAEGVRTRSQTRGVGSQEDPVAIEVIEDSNDEEYVPEDGLVACPICNRRMKNEAVFRHLDTCTGEPAPPKQLNFGSLQPAAQRSKDALNKTPERLPIINYSLLKDNVLRKKLKDLGIPNTGPRPLLQRRHTEWMNLWNANCDSKTPKSKRELLRELDIWERTQGGQAQISGDVTDTVMRKDFDAAAWSTSHDDDFKRLIANARKKSEAQVRTTIPQENVGTIQATDQLASQTTYQPSSAPVVEHTEAIHAAEDAHPPERLPVEDKTVIVPEVQAQTLQGSVDSQMTNAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3M1</accession>
    <name>A0A8G1R3M1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_372604</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515566.1">
        <property type="nucleotide sequence ID" value="XM_025656044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3M1"/>
    <dbReference type="GeneID" id="37159446"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH57644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="661" mass="74479" checksum="DFAD1AFA1773BE6A" modified="2022-01-19" version="1">MPVTKQQPKRDNKKPIACHRCHSHKVKCSGGQPCSRCRRAGCDDECQYTLRDRKLKVQESYLDELLTQNAQLREQLRSISTPQSSSATTAEGSIPQESYPPVQNPLLGERAWFYPYDPSAPPIYMGDAACTAFATRLRQFLTGDPNTAHVARTQYTPESSLLEGATQWPGLAQARLLVRIAFNQLSRVYHLFLRKSTIEHLESIYRTPSLRDDPAVMCKFFALFALGEVYSSRANSSPTGRVPGTLYYVRAMGLIPILPERPGVIHVESLLLLSLYSYFLNRRHSAYMLVGSAMRLGLILGLNHNIPERQCTDPIERQHRVRLWWAIYVFDRMYTSKFGFPLQIRDEDIHVDMPTDVASPAAEEQFSDTAYSVASIRLSQIIGQTIDKIYCRKQHAESFLQREQQLLLALQDWLKSLPEHIKLRSEDSPPPKHIVSLHLQFNQCVILATRPILLHALLHHSNRDDSEDLPQPVITLSEACIHAARHSHALIIEEWVNGSLPMYGYFYAQYFFSSCIALVISSLLPTIGNPADLESLDTAIEILHRMSEHGNLAAAEFYENLKRVKKTLATNSGIVNDSHECRSQTPRHSLASLSAGGPAADPHAISIVPATGYTTEMAFLEPTMQDFLGRSENEIDAIQPYDLFIDDHATIAAWPATMWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3V9</accession>
    <name>A0A8G1R3V9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_520037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516093.1">
        <property type="nucleotide sequence ID" value="XM_025665096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3V9"/>
    <dbReference type="GeneID" id="37168498"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32410" checksum="BB9E712CE6F998BA" modified="2022-01-19" version="1">MAALFFAPHPSTPQPQLFHPSSSSPGHQPQSPWITRGNAQLRLPTDACVHVGNLSSSVCPNILQHELEQLFSQFGVCWAQDRSHAQAAIGQHQNIFLRDRPLRVEAANGLRNRGESVVNHDERAGLNTSPLYMPSMAIPPSQPAAYGPPLLYSWLPAVPVHGSLHIPPPVSGVIPPAPSYPTHHTLSSQAANAHTPQSPSFSSSSSSNNLDTQPTTPGCDEVVECEANQEREGIETSRSNLPCDMLLSTGRTVRDYVNEMKRVRGIDLNEEATLELILEVEEEARDQGLLPVLTSKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3W1</accession>
    <name>A0A8G1R3W1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nonribosomal peptide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_511694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517020.1">
        <property type="nucleotide sequence ID" value="XM_025664619.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37168021"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19531">
        <property type="entry name" value="LCL_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide synthase-like phosphopantetheine-binding" evidence="6">
        <location>
            <begin position="1032"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="domain" description="Polyketide synthase-like phosphopantetheine-binding" evidence="6">
        <location>
            <begin position="2533"/>
            <end position="2601"/>
        </location>
    </feature>
    <feature type="domain" description="Polyketide synthase-like phosphopantetheine-binding" evidence="6">
        <location>
            <begin position="3659"/>
            <end position="3729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3634"/>
            <end position="3654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3977"/>
            <end position="4005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="3977"/>
            <end position="3992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH59098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="4005" mass="444528" checksum="76497FFF2843D210" modified="2022-01-19" version="1">MDQANNDSKKTHCFSQATVNATWAARLSPMSVQAVHQASAFQEEMVVATIADSKHQVNVEAQHFICRERLNVAHLNNATHALARRHVVLRSLFCWNDHATKQHPARILMLVLGPDYPVANIKLVKIRQWHGEMPWRLTINSLPDQKGSRLSLCYHTAILDESSACRMLRYLWDELQAPGSTVVSDFIAAHKGLAFRRSHDMQCRVRERFAGAPPLLAVLGSTKPLDREGYGVTIDKVAMPYARADCLLRARQALYMALCTLDGTQEATFLELTPHRGALPSNHREVLGPILQPQIRWTQHDSHTSLLRVAESLASGCDINHAFSPGELCSFISNAAYRPSVSLICHIESCASTGVGTWTWEGKDSWSDVPLVIELIPCGGDSYLVRNCYHRDLFTDNTIAAFRQFFCASLEWQQHEHDTRRDITLEFAVHSILSSCPDAGVHLENQKKIQTNNKHVGESPETIMLSTTSHITIEKCTGHGHYSLSNMRAEGGACAHDLLERSARRFPEKIALQYEISDYLTYKDLNDRCDQLAESLTYWIDRTQQTSPGEEIIIPLSFDKGFELVIAMFSVLKAGAAFVHIDASLPASRIAGIIRKAGAPFILYDGKADTPTLNEVARREGKAIVALNELARMQDKHTLPFIRSEQLGSSLAYIQVTSGTTGEPKCIMIEHRNLVAFMEADEPDFLGTWTTNKLQLSNRTFDIAMADIFGTLGRGGRLVFGPDAAILSSLAEWLEMTSVTDLNTSPLVADLLKDHVPAYLSVLMVGGEPFHPSLVEGIPKECRLYNNYGPSETTFVATTYTVSEEDKDKSNVPIGRSFGSCSIHILAPEGTERVKSGDIGELCISGSQVSRGYLGQPEITGRSFVSDPSAKDEKCKLYRTGDLGRFLPNGKLEYTGRKDKQVKLRGQRVETLEIEIEMRKHPRVKACAVATGDSSHGIALVAFIETQPNHQDSFTDATAEECDWANLVAELKTVLSQSLPDYMIPARIVRLDDGLPRLPSNKLDQKALSSRATEVLASQASQAGLEYVHPRDELERHVCEAFSNVFSCQVGITNSFLDLGGHSVTAIRVASKIRKHLHTVITFRDVLECLTPETLSARIRASAGSKPQSLRTYRAPDSMTVEQSFAQGRLWFLEQLHPNLSWYHMPLAFRLRGRLHLDALEAALLALEQRHETLRTTFEVKGDMNVQVVQPFLPKAIRILDLTGDHGPGDERLYSVLRSEQTKPFNLTDEPGWRVAVVRVSSQEHVLSLVIHHIIADGWSLGVVLRELALFYSEALHGKDPSLILPPLPIQYRGYSLWQRQEEQLRQQQRHLAYWTQQLRGSHPAEFPCDKPRPDVPSGQAAVRGIKIGGALYSDLERLCKRHSITPFIVLLAAFRAAHYRMTGAADATIGTPITNRNREEHEDIIGLFVNMQCMRVEISESDSFEVLVQRVKETAAAAFEHNEVPFEMIVSELHPIRDSSRNPLIQTIFAFHPERVNQISLEGIDSELITLTHATRFDLEFHVCQCGDGLEGDLIYSTELFHSRTIEILLSTFQDILRVGLEVSHSVIETIPLSSGTSALADMGLLDIRRSPYPRTSSIIDVFREQVAAYPDRTAVKDNQYQWSYTRLDLESDKMAGWLRDLKLPKETVIAIFANRSCETIAAFLGVLKANMAYLPLDIKFPAARIETILSFIEGNRVVLVGSGCELPITHLDGVDVVPMARLSSGIGQSPAYVDNIMPTPKSLAYVMFTSGSTGQPKGVMIEHRAVVSRVKGCDLLKEEVTAKPFAHISSIAFDAAVWEIYTPLLNGGTVICIDSATITDFEAFSSIFHAEGIEVALITPALLKQLLTDSSASIFELHTLVVGGDRADPKDMIKARKLVQCNVVNAYGPTENTVISTFYRLPEGGGYHNGVPIGQAVPNSGAYVVDQQLCLVPPGVIGELVVVGDGLARGYTDVRRDLNRFVNIDIRGRVLRAYRTGDRVRRRPVDGQLEYIGRLDGQVKIRGFRVETEEIEHVLRSSGLVENAAVLFQQPDNQEGRLVAFVTMLKGGDKHVPMDEVARGREEQESEQAWKQIFSEVTYDSQIDPREAGRDFSGWKSMYDGADIDKEEMGEWLDDTITTLLNGGPPGNVVEIGTGSGMILFNISNDLQTYVGLEPVQSIVEFVKTMMGKVNPTLASKVQLHIGSASDLDKISSDISSPDIVVVNSVAQYFPSAEYLFKLILDLLRKHQAKTLFFGDIRSYALYAQFQVTKALHGQEKITPEYIRQSMANTVENETELLIDPAFFTSLAAEFPDLIHHVEILPKRMRATNELSCYRYSAIIHAVRQDYLPIIHTIDADQWIDYSAQGLSRNGLLDLLKEGSESAVVAIANIPHSKTVFERLVVEAFSSRTTMTDIGWLPSIRQNADKVDGLSAMDLVDLGALAGFHVELSWARQFSQHGGLDAIFHCIKPQDGRQRTMFRFRSDHEGRSTGDFSNRPMQGQPTRHIIRELQHFLKIRVPWYMVPALVSVLEDMPTNHSGKIDRQALSQIAATMAPRQAPADMTFVCPRTKFEVIVCEAFGRVLGCEMGVTENFFDLGGHSLMATRAISKIIERTQCAITVRDLFDCPTPEALANRIAKIRDESSEEAESGRIQGIDEFADHEPVVHDEWNQAVEAAGICTADIVHIIPCSPFQEGVLTADLVLGDSPAYLATMKLKFDGHLNVRALQSAWQLTVAREEMLRTAFMPSTQDISLNGMCSGAFLQAVLRYDSNEVKRVSTLRQQEYNQPPDLGMGHIPVSLALRQGYVTGFMQLELTMHHALYDEAYLSYILNGLSRDYHHAQSHSLTNDDNSSHIPFIKFIRTLQQKDQSVGSSFWKKYLDGAPACTWPIPCGLRGPMDGIQFPHEVRAEWNGDAEALSKIYSTTPAGLVRAALALSIAVHSDSDDVIFGEVSSGRAHSEFVKGPCIATHPVRISLAVNSKQHSSDGRRGGVSIEELLTRTRDAYLDTMPFQHLGLEPIRRLTENPDLLPFQVLFVFQAQVTNAKNHRFPWDRFSIADGELKRTDFPMVLEVFCQELTGHLHMRCVFDPAAILPEDADWVLQHIIDSIDLMQTRSMQHQEDQYPEAKLVIKEREITVIEQLLGHQDGGSSEGGGALSTVIELFRKCAMEMPDKIALQVQRSDFVTFRQLDELSNQIAFGLEEILNYLTSATTKQRYVPIFFEKSYHMVGAILGILKAGAAVVPMDIEHPMQRLETICVTSAANVFLWDGINGGEKLQSLVKSTGATALTVNDLLQYTSQTYKQKILPLNSLAYVLFTSGTTGIPKGVMINHRNLASFLSSNRGSTDCSWTSNRLALLAPTFDAAMGDLFATLCKGGRLLLGKQQDILSGLSHCLEDLSVTHLSLTPTLGTLILNDLDNEGLSFLRSLVFGGEPFPLSALSRVPRTMNVWNGYGPTEATIEIAACKVQGLDVDVCGGRSFVPIGEPGHNRHIRVLYPETSEQVPLGSVGELCISGLQVAQGYLGQADLTAKHFTPDPFSPTGRGRMYRTGDRARLHGDGYLEYLGRLDGQIKVRGFRIDTEEVCSVVQKHPQIIACAVTKLQSSDSGIETLTALVEVVHPLQPGDVICEATVKEHLAQSLPSYMVPAFIWVQTTPLPRTTSGKLDRIAITKMAEDRHKESLKDRSRHPHTPVRAAPGSLEDKIASIWAKVLGINEDSVDITAAFHRMGGDSIRAIALLAILRRQELHLDLIDVSQTSTVQSQAARVRQGSAAKNNARYLHFHMRQGSMATVVLVHPFLAQSTVFEPLLPLLDGTIDVLLVDDPFMGAARYPETLSQWASRYLADMKEHIQADHPVIFGGYSFGGVIAFEMAHKWDQLYGAHSSSVVLLDPGTYEVDNIVWKGESDKDNLIMSSLGRSEISLQDILPLRKCFDGYVRALEQSECPPVYEGKCLHVALPDRLQDGVVDWWKAHCTKITLGVVDCNNHYALMKDAGCVARISRFINEHCNAVIEENRAVSSASSESRMYGGSSRTDVSTEDGDVKEQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R456</accession>
    <name>A0A8G1R456_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_478858</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514422.1">
        <property type="nucleotide sequence ID" value="XM_025662914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R456"/>
    <dbReference type="GeneID" id="37166316"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="28"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH56500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="328" mass="36953" checksum="980FC83224A35A50" modified="2022-01-19" version="1">MLREVKPKNARTARILKAKEPQLIEPPKRTLLLHGSKCPQPLHTVLKTFHSLTRPNSVLFHKKNANIHPFESVESLEFLADKNECGMVVFGSSNKKRPNCVTLARVFNSKILDMCELLLLPNQDQTAGLESLQIGIGMRPMLLFSGSAWDDETSTAHVMLKSMFVDMFKGETSDKIDVEGLQYVLMIGAEEATDGLAPVVHLRWYKLRTKRSGHKLPRVELDEIGPKFDFKVGRLQEAPREVMKEAMKQGKRPNEEIKLKKNIGLDSIGDKIGRVHLGKQDLSGLQTRKMKGLKRRAGVESDDEEGDADMMDVDEISEDEGRKRTKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R483</accession>
    <name>A0A8G1R483_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">glutaryl-CoA dehydrogenase (ETF)</fullName>
            <ecNumber evidence="11">1.3.8.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_449300</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="11"/>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516119.1">
        <property type="nucleotide sequence ID" value="XM_025660136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R483"/>
    <dbReference type="GeneID" id="37163538"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="16">
        <location>
            <begin position="48"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="163"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="14">
        <location>
            <begin position="279"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH58197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="428" mass="46822" checksum="FEBA2D0D201B7E4A" modified="2022-01-19" version="1">MNPSSFRRASRHLHRLCRAPATSRNASVRGYATTFNWEDPLVASELYTEEELAIQDTARQYCQERLLPRVLDAYRNENYDRQILTEMGELGLLGANIEGYGCAGASTVASGLITKEVERVDSGYRSGMSVQSSLAMTAIHDFGTQELKDRLLPELAKGKLAGCFGLTEPNHGSDPGSMETVAREHPTKKGYYLLSGTKTWITNSPISDIMIVWAKLQTTGKIRGFVVERSQCPPGTLETPAIKNKTALRASITGMIQMDDCPVPAENMFPEVQGLAGPFTCLNSARLGIAFGAMGALEDCLNRARTYALERKQFKGNPLAKYQLIQKKLADAATDAAYGTLAATQVARLKDAGKCTPEMISMVKRQNCDRALANSRILQEVFGGNATSDEYHIARHVANLFVVQTYEGQSDIHTLILGRAITGVQAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4H3</accession>
    <name>A0A8G1R4H3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Complex III subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_520313</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCR10/QCR9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515507.1">
        <property type="nucleotide sequence ID" value="XM_025665125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4H3"/>
    <dbReference type="GeneID" id="37168527"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.260:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH57585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="86" mass="9901" checksum="47D53967FA8D3B16" modified="2022-01-19" version="1">MAGAGVPVPVRFRYLPACLPFHSGNRYLGLIRRNAVYLTTIFASAFAFELTFDTASNKVWDSFNRGRQWKDIKHQYLNKADDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4Z2</accession>
    <name>A0A8G1R4Z2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase, H3 lysine-36 specific</fullName>
            <ecNumber evidence="4">2.1.1.359</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">SET domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO85DRAFT_439394</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="4"/>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514812.1">
        <property type="nucleotide sequence ID" value="XM_025658713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4Z2"/>
    <dbReference type="GeneID" id="37162115"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19172">
        <property type="entry name" value="SET_SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1740.100:FF:000002">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025788">
        <property type="entry name" value="Set2_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044437">
        <property type="entry name" value="SETD2/Set2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013257">
        <property type="entry name" value="SRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038190">
        <property type="entry name" value="SRI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08236">
        <property type="entry name" value="SRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51568">
        <property type="entry name" value="SAM_MT43_SET2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="20">
        <location>
            <begin position="164"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="221"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="19">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="17">
        <location>
            <begin position="611"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="540"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="669"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="789"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="691"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="789"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="824"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="880"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="902"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="921"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="939"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RAH56890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="963" mass="108200" checksum="6536CD83C6352421" modified="2022-01-19" version="1">MSPHDYADHQSESVADAVTAMKLESDAAPENSAMPNGGGAMIKDESSNAASNASPVPTPKAERSRSSSRAPVKKEENYEDDGSNVKGAENNHGDNVEEEKVGGDIIVKLEPGQPPKLTRSSSQKVVPRPPQLFAHLPDSTAEAQATFDLMDACTYANKYMGYTEHAMECDCAEEWEPSVSKNLACGEDSDCINRATKIECMGDCGCGPECQNQRFQRREYAPVAVIKTEKKGFGLRAEADLRPHQFIFEYVGEVINEGQFRRRMRQYDEEGIKHFYFMSLSKGEFVDATKKGNLGRFCNHSCNPNCYVDKWVVGEKLRMGIFAERHIQAGEELVFNYNVDRYGADPQPCYCGEPNCTGFIGGRTQTERATKLSNATIEALGIDDADGWDTAVAKRPRKKKTGEDDEEYVDSVQPKSLEENGVTKVMAALMQCKEKWIAVKLLGRIQRCDDERVRNRVVKMHGYQILNSQLGMWKEDHNVVLQILDILDKFPRLTRNKIIDSKIESTIQPLTSCGDERVEKKSATLLQVWSTLEVGYRIPRMKRNPNATTPAVNQFGRRENTRDERRRSKSRSRSRSRSIEAPRGPAAQTRGGHGQRNPHHHGPRPFRRLFNPLPPGWFQAESNGRTYYYSARGDTTWTRPTKAAPQPPPAPKESRDKALQDIIDGIMNAKENTPKEKSGTPATPQASRPTPDMKDGQEKWRSYSEEKRKKIYENTLYPHVKYVVDKFKHKLPKDDLKRYAKDVAKKLVNSDFKNNRVGDPTKIDDKQQKKVKKFCKEFFDKAVVKHRAYEQRKAERQSKEPDAKPIDAAAEAVEDDGLDVKMSDDEDDRVPTQDDETPTTMTDEVQGLLKRKREDEPSTGDGSTTEYTTPSSSKRQRSSTPPPPPPPPMSPGNEQGQSGEDGNMKSDADEPTPADKQDLGSPPPPPPPPPYPEQEMDTNDNHFNPEDGVKELNPRHIGIEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5S0</accession>
    <name>A0A8G1R5S0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_256333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH60009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517931.1">
        <property type="nucleotide sequence ID" value="XM_025654982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5S0"/>
    <dbReference type="GeneID" id="37158384"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH60009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="156" mass="17632" checksum="464C1AA60BE9CEE8" modified="2022-01-19" version="1">MPEKLFAARDGVRRIHTCKAGLSTSKSTLLVSARQSRCLMDRLEGREGRMRRDAICRRGFAYMENKLNAELAFTALVGAGQHGEDLPGPAQQRATRQDALRGAVTWGYFHRMVQAPFSGSHRNVKVNTNSVYSWYRASIYPHKNNNPIREIRSPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5S1</accession>
    <name>A0A8G1R5S1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_478456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515232.1">
        <property type="nucleotide sequence ID" value="XM_025662901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5S1"/>
    <dbReference type="GeneID" id="37166303"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2140.20:FF:000003">
        <property type="entry name" value="Arylamine N-acetyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="322" mass="36881" checksum="0453C8C47609CB2C" modified="2022-01-19" version="1">MASNTYSYTPDQLTLYLERIHYGSNESATSSSRLQQAQQAVKADPLGTLYEIQRRHLASIPWGNSALHYSNHRTIDIRPACVYEKLITRRLDGYCMENNTLLYGVLKSLGYAVYATGGRVCLAATGQAKEGLERLYTGMSHMVLIVLIEGEKYAVDVGFGGNGPTRPLPLKEDVVSVCMAPTEMRLVHEPLPEYADQTQKVWIYQIRYTPDSRWIPMYSFLGTEFLPQDFEIMNYATSQRPTSWFTQSLVCTRFIMDEAETVVQGMYFLVGREVKKRQFGKTEVVETLERDADRVKALEKWFDMHLRDYEVEAIRGFVSEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5S2</accession>
    <name>A0A8G1R5S2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_476423</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="6"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517730.1">
        <property type="nucleotide sequence ID" value="XM_025662782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5S2"/>
    <dbReference type="GeneID" id="37166184"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF12">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="35"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="299"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="8">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH59808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="421" mass="44226" checksum="E9B35B99D03120FB" modified="2022-01-19" version="1">MSSAQQRLTSIANQLSGPGAASGKQRVLSKNPDDIVITLAVRTPLTKARKGGLKDTKLDDLLISLLTSVREKSNLDPNLVEDVCVGNVLCPGAAYVARSAVLAAGFPVTAAASVANRFCSSGLLAVQNIANQIMAGSIDVGIAVGAESMSTNADGGSPEMSSKIMNHPIASQNIQPMGQTSENVASQFNITREQHDRFAANSYQKAEHAQKAGWFNDEIVPVKTVIKDPKTGETKEVVVDRDDGIRYGTTAESLGKIRSAFPQWTPSATTGGNASQITDGAAGLILMKRSRAQELGQPIVAKFCGATVAGLEPRIMGIGPSIAIPKILSKFGLSKEDIDIFEINEAFASMGTYCVQKLGLDEAKVNPRGGAIAFGHPLGCTGARQVVTALSELRRQNKRIAVTSMCVGTGMGMAGIFVSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5X1</accession>
    <name>A0A8G1R5X1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF341 family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_511658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517004.1">
        <property type="nucleotide sequence ID" value="XM_025664617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5X1"/>
    <dbReference type="GeneID" id="37168019"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF4">
        <property type="entry name" value="ESTERASE ALNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="235"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="474" mass="52609" checksum="C03BDB096A60E519" modified="2022-01-19" version="1">MHFLCLHGAIGNTETITIQLAPLLKELNTDNSITTFHYLNGPLLVSPPPGFEAYFGVGPHYRWIDDGQKPGKSTIRRVRDLPTSESNDDAMREVLGDVHCRNYTDLMDYIEGVLEKNPEIGGMIAYSEGAAAAATYILDEQRRHREDGRERQIKCAMFVGGWPAMRRDTKGFILADDGGDEMIDIPTLHVLGANDPYRYGSEALFETCDPDAAEFFDMGKGHTLPRSGLVISELAQSSQTLSAQLGPLQKNLADDNTASFYCVNAPHTTTAPGGYIEYFGHPPHYRWLNYVGVGIDAIYDTVRGARNKQLGTPEDTFRSLIPPELSWVNYEDVLSYIEEILEKNPDIEGLLGYSEGATVGAAYILREQRRERETGRTRQIKCAIFLAGIPPVKAENGFIFADEQEEMIDLPTVHIVGANDPFRIAADCLYNICDTDSAYFFDTGKGHTIPRGGPVIDELGDTIRELVQRTKEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6E1</accession>
    <name>A0A8G1R6E1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_506473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518863.1">
        <property type="nucleotide sequence ID" value="XM_025664373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6E1"/>
    <dbReference type="GeneID" id="37167775"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="474"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH60941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="652" mass="72800" checksum="4D09AAB1DBE53C72" modified="2022-01-19" version="1">MDADILDIVAQRGGRARSACDLCRHRKIRCDGEKPACENCHFAGVTCTFTVTGQPRKTIREQLAEAKARVQELESFIAGRHLPGAVSPNIQLQDELRSASPCPPLSLFAAPSHPQNSSDFDIAMEIFKQHLEVSWPGTTNSPQRNSFHAAVYRQTGAVLDLHGFLARVTESYKAQYASISPAISTPQWPSYALIQKCLDYYAAKSMYSMFPVVDVPASQAVLDALVSGRTDSLPTTAEKAHLFAFAAFITKQHQHQPQFADTDPEAYVQAVLTLVPKLMLELASVWKLETFVILALHIAPAGYPQQAQLLLSTAIRILYQLGGHRITPPPEYQPQASSTTTTNDTKSHSHLRAIFWLCYSMDKEMCIRSCSPPLIHDIDVDLDFPQTYIGSTTHSPPPPRQSPSSSSASLSSYNGNEIPLLYPSDIRLAIFKSHIYNRLYSSHAQSLPEARRLAHIRQLDQDLSELYAEFPLGHTPVHTPRSETSTPNNRDPTILSSSSSSNEESSNHKLVNIRPINIHLEYHHCIRKLHEASITTSLSVVSAPLASSLELYYQASRSTLLYYLNSGKGGLVDRFSVWIHAQFILSAILTVFWCLIENPDPRSASFTRDLRMLEDMRGLFACEVFDMDGEGRFFPPAYIVDGFLSWDYVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7K4</accession>
    <name>A0A8G1R7K4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein translocase SEC6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_485337</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518690.1">
        <property type="nucleotide sequence ID" value="XM_025663322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7K4"/>
    <dbReference type="GeneID" id="37166724"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH60768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7842" checksum="A6406862F72A89FA" modified="2022-01-19" version="1">MSDQVQELLNVPREFLRDGVQFVNRSQKPDKREFIKISQAVGTGFLIMGFIGYIVKLIHIPVNNVLVGGA</sequence>
</entry>
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    <accession>A0A8G1R7V1</accession>
    <name>A0A8G1R7V1_9EURO</name>
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        <submittedName>
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        </submittedName>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 112811</strain>
        </source>
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    </dbReference>
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            <begin position="1"/>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="172"/>
        </location>
    </feature>
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        <location>
            <begin position="187"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="306"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
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        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="324" mass="34155" checksum="01A085136CCCBFC1" modified="2022-01-19" version="1">MHSVSKGLLLVLSSHLLAATARPVATETSTATATETPASYGDYGNYGNYGNYQAYKRDGEPEADETTSSVSSTASATSTTAAGYGNYGNYGDYGTYGSYQNYKRGEEPDPSLSTTTTIPTTTAPASYGDYGNYGNYGNYGSYEAYKRGEEPDPSSTTTTAVPTTTAPASYGDYGNYGNYGNYGSYEAYKRGEEPDPSSTTTTAVPTTTAPASYGDYGNYGNYGNYGSYEAYKRDEEPEVSSTASATCSTESATTTAANYGNYGNYGNYGKYASYGSYKRDAEPQPDQGNESSTTSAASTTTAAAGYGNYGNYGNYGKYASYGSY</sequence>
</entry>
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                <person name="Nybo J."/>
                <person name="Theobald S."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
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                <person name="Salamov A."/>
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                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
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            <strain evidence="2 3">CBS 112811</strain>
        </source>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="109" mass="12140" checksum="388C307DE5A822B2" modified="2022-01-19" version="1">MNGVSPGSATPPFGEGGPRDWSLHWAGQSSSWSIAFVFWREFAVWGTVHVSTIVWWLICVGKSLIMAPDWLFDWPVSCWCVHCDGRVGSLIYILQFKAVTLLARITGVV</sequence>
</entry>
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                <person name="Riley R."/>
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                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 112811</strain>
        </source>
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    </dbReference>
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            <begin position="1"/>
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            <begin position="71"/>
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        </location>
    </feature>
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    </evidence>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="171" mass="19019" checksum="7A7CC99F3043730B" modified="2022-01-19" version="1">MYMSSTLTRASLINLLLTTTARIAPASATLTTTTSSYHTPRHFLHQATLPLHPHCSAIHLYNNTNKYPKEQSSYYSTMSTPNEQQQRDEENKPILALPDAESATKLDVSGDGSAVALDHLGPVVVNQDGTLSRISNWEAMTEIEKKNTLRVLGKRNKMRLEALKRERGEGN</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Theobald S."/>
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                <person name="Lyhne E.K."/>
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                <person name="Riley R."/>
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                <person name="Salamov A."/>
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                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_025661453.1"/>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="32"/>
            <end position="76"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RAH60809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="103" mass="11771" checksum="CE31625C30567F51" modified="2022-01-19" version="1">MDAGYEHGRKGEERGGRKLTCNGQYGNAAWTPVMIRRTPPKPARSKWGEDITPLVQSRGLDRHTHQDSSQNSSLSTMSGHLQFNLYHGRHLPIVWHNERKWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA26</accession>
    <name>A0A8G1RA26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518552.1">
        <property type="nucleotide sequence ID" value="XM_025655755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA26"/>
    <dbReference type="GeneID" id="37159157"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH60630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="172" mass="17687" checksum="C0587B3802049421" modified="2022-01-19" version="1">MGGLGGAPGAAGPNMQGMSEQEQAMVKMMYSAMESCPMKTVMAGTMGFGLGGVFGLFMASMSYDSTFTPQGKAIADLPWKEQVRRGFKDMGQRSWSSAKNFGVVGALYSGTECCIEGLRAKNDLTNSVAAGCITGGILGAKAGPQAAAAGCAGFAAFSAAIDAYMRMPEKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB20</accession>
    <name>A0A8G1RB20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_517363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519077.1">
        <property type="nucleotide sequence ID" value="XM_025664900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB20"/>
    <dbReference type="GeneID" id="37168302"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35887" checksum="1D1BB79825D1E948" modified="2022-01-19" version="1">MADLSTLREVILPTLFSWKSLAIVLALLNLKNIPFSWHIRLLTHLLLNLRRSPTSPPFPTCPPSPTLTSKNQKNIQTHPIFHPHTLTTRTSLWETDYNFHKSNSTYFSDLDISRTAIVTRVYTPGLALVSLEFDHELKNGKDENAKVNVGKKVYVALGSTFTSFKREIGPLQRYRVLSRVVGWDRKWVYVLSAFVGMGSGNGKNGGKANGKVFATAVSKYVVKKGWVTVPPERVLRASGMLPERSVGDGEGEDGVVVEEEEEGTVEGIVEGVGEVLSKDDNNATGQGVSDWTWEMIEEERVRGMKIVEGYVGLDEKLLAEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB32</accession>
    <name>A0A8G1RB32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3 14">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_363203</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
            <location evidence="1 14">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3 14"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520369.1">
        <property type="nucleotide sequence ID" value="XM_025655652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB32"/>
    <dbReference type="GeneID" id="37159054"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052843">
        <property type="term" value="F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000059">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="17">
        <location>
            <begin position="102"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp fold RimK-type" evidence="16">
        <location>
            <begin position="326"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="484"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="654"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="884"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="981"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="25"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="904"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="985"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH62447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1257" mass="140624" checksum="96CDB3953F3A0952" modified="2022-01-19" version="1">MEAKPDSGASSPSVGSDRIDKGSFSLLSEPTAPNSSKGNTNGVQVQGSQPYQFESSSSNWNVGQGPNPSVRSSSRAPRRLSGSTAASSISEAEVSGTPHLGRIGVCALDVKARSKPSQNILTRLQSKGGFEVIVFGDKVILDEAVENWPICEYLIAFFSDGFPLDKAIAYARLRKPFCVNDLPMQKVLWDRRLCLKILDQMSVPTPKRLEVNRDGGPTLESPELAEHVYNLTGVKLEGPSDGTGGGASRTMNVRMSDDGDSLIVDGKVFRKPFVEKPVNGEDHNIHIYFPNDQQYSGGGRRLFRKVGNKSSEYDPDLTVPRSVTETDTSYIYEQFLRVDNSEDVKAYTVGPDFCHAETRKSPVVDGLVRRNTHGKELRYITKLSKDEAAIASKISNGFGQRICGFDMLRVGEKSYVIDVNGWSFVKDNNDYYDRCAAILRDTFLNERRKLEGIIEPVDAIPADSGHSWRHSMSHRHTLKTLLKSPSASKLHGSQAGLRSSDTGSSDSIVSRPITSSSAEKVDNGNGHADPSGLDKLAHPKIYTSQNSKSSILPVDLPTEGLPPPPPPPASKHSWKLKGMVAVIRHADRTPKQKFKFTFHSQPFIDLLKGHQEEVVIKGEAALASVSDAVKVAMDQNLEDMDKLKLLRTSLEKKGGWPGTKVQIKPMFRKRKPEELRGQTSSVLPTSPSEPPQHELLVSTQDQHSAENDQLSRPQTRSDSISGATFSRFSAAENDLILDKLQLVIKWGGEPTHAARYQSQDLGLNMRDDLKLMNKEALNNVRIYTSSERRVSTSAQIWACSFLDQKELPENFIQVRKDLLDDSNAAKDLMDKVKKKLKLLLREGSAPSQFTWPKDNIPEPSVVLATVVELMKFHRDVMRHNFRRFDESSSQPSGTDEINDGCPSFQPNTGCEKPSLSSIQGRWCTGEDPMLFKERWEKLFAEFCDTEKVDPSKLSELYDSMKFDALHNRQFLEWVFMPPDSDDSEDEKHHYTPKNTRRDDSVSPNNESDNDKNEEQTEGSLFAHRFGWKKRMHAFELMPHFRALDDSYDHYFKLYPGSSSTKAKIDGRLSKLRELYKLAKVLFDYVTPQEYGITDTEKLEIGLLTSLPLLQGIVRDLEEVQASPDAKSFFYFTKESHIYTLLNCILEGGIQTKIARTAIPELDYLSQICFELYEAKDCESSTNSYSIRISISPGCHAFDPLDVQLDSRHAIGCAPRRSLTAHQDWKEVIETLKARFDTVKLPKTFIAVNLSDKHGSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBA3</accession>
    <name>A0A8G1RBA3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_446435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519197.1">
        <property type="nucleotide sequence ID" value="XM_025659504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBA3"/>
    <dbReference type="GeneID" id="37162906"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
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    </dbReference>
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        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="117"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="326" mass="36350" checksum="2DFE7BE241240177" modified="2022-01-19" version="1">MDNPQDRMVDDLRSAQAKAFGVVAAKSHTTPRRQARERRDYLYRRALTLRDASIAEKRAQLKASLASGKPLDPSIAEDKSLREDFKYDESITPDNQNKDGDVDLDDEYALTSGIADPRPIVTTSRSPSVRLGTFAKEIRLLLPTSIRLNRGNLVLPDLVSSATAAALTDMILVHEHRGTPTAMTISHLPHGPTASFSLHNVVLRADIPNAARGTVSESYPHLIFEGFKTKLGLRVVQILKHLFPPRETGKVGNRVVSFVNKEDNIEVRHHVFVKTGYRDVELAEVGPRMTMRLFEIRGGTLEKGSSGDVEWALTQYTRTSKKKDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBR8</accession>
    <name>A0A8G1RBR8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_445569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520064.1">
        <property type="nucleotide sequence ID" value="XM_025659294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBR8"/>
    <dbReference type="GeneID" id="37162696"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018844">
        <property type="entry name" value="Dnt1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10407">
        <property type="entry name" value="Cytokin_check_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein Dnt1-like N-terminal" evidence="2">
        <location>
            <begin position="55"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="887"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="896" mass="97482" checksum="324804A4D30EA10B" modified="2022-01-19" version="1">MVFLRLRVKVYPREQVAPTPSFSFRSILGDRDRDRDDASRSANGSGGGKPVAFLLVLEKPEEITLGGLAGLIQDKWRKLRPNAEPLDIKKLLDDDHESDDLDADMTVAEVFVDNGRARQDMSDQRGTVRVIQKPGQYAPVRFPSVTQDWDAAAQNFERQIQVKKEAVKKAMDQIPTIHEEEGNEYSNAGSASARSSAWSPYENRRSEIPVSSVEKDEVPGSPAPWEKKSVLHEEDSQNQIGSSIAATPLHKRMQSQELGDSPSHTPTPEERPASRHSSSQGSAKQQAKETTEGQANGSHEMESIDGSLSPLSTRKPLQRRQIPETQPPAPVVNVDSESESESESESEDETGDENDENLAPPSAQKNKLQNGDVDMHDTVGSTQEQPQSSSRKRKLSQDDFEPSKEPRLSEPGSTHDTPKGNKHGTVTVEDSAIPQPNFLASNGTPEIPSSAPTIRRGSVSLAPYSTPSKAQAPLDKVKNLHSALRKSSPAERPSERRSVSFAESDEVVFAGSQPVPKSNPQSTPKAHAKGSDASRRTPDPSSMVFPASVPKERLDQLLEEANRKIEQDKQYEEGLQAKLQAAREQKAGAAYIRKLQELSDAWTALKKAEKHQKTKTVAQRKFDSLQKEVDKLEAAQKLKPASATPQKKQQSTTPSSQPADAAKLPAPHDTKAANGTTSPASASRAQPQKTSPMQMRTRSASKVDASPRIASEPQSSLVSDNLDLPPMSRTVHRAGSSKPDGTPARASTVKSPEKTSKPSPQAPIELSSDSEESEESESESESESESEEEEEEEKKPAIRQTASSPVKGNTATPTQVPASQPAPSQTWARPSSATRTTRTTLKSLIQNQKKELEAKTQPKRAANSLPQKRSVYSPPSDDDSDSESESESSSSDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBY5</accession>
    <name>A0A8G1RBY5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 13">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_444656</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="14">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 13"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521291.1">
        <property type="nucleotide sequence ID" value="XM_025659071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBY5"/>
    <dbReference type="GeneID" id="37162473"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000027">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.110:FF:000003">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="16">
        <location>
            <begin position="43"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="15">
        <location>
            <begin position="310"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH63369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="822" mass="93072" checksum="F6F1B808C499FF2D" modified="2022-01-19" version="1">MHLSKISAYLTPVLNAAAVLSSQAPADDLSVLSSEVARANNQSLLWGPYKPNLYFGVRPRIPNSLFAGLMWAKVDNYATAQQNFRHTCEQNEGMAGYGWDEYDIRKGGRQTIHDAGNSIDLTIDFVKVPGGQHGGSWAARVKGVPREDADPDQPTTVLFYAGLEGLGNLGVEGAPEDPYGFAGDVKLGGFTTDLGDFSIDVTSGPESNEYPEHGHPTYDEKPLDRTLVSSLTMHPEQLWQTKVIMFTQMKKEVDEMVEKYGSENPPPPYQLFTIKNEPGDGNMHLVQKVFKGSFEFDILFSSASSPQPMTSELLTEQISSASLEFSERFESIHPPQAPFDTAEYTEFSKSMLSNLVGGIGFFHGTDIVDRSAAPEYDEENEGFWEETAEARGRAQPILEGPKDLFTCVPSRPFFPRGFLWDEGFHLIPVIDWDTDLALEIVKSWLNLMDEDGWIAREQILGSEARSKVPPEFTIQYPHYANPPTLFIILEAFIDKLDAKKNASMQTYADSGASDNLRSIFVDQPELGEAFIRSIYPLLKKHYYWYRSTQKGDIKSYDREAYSTREAYRWRGRSVQHILTSGLDDYPRPQPPHPGELHVDLMSWMGMMTRALRRIAVTIGETEDAEVFKTYETAIERNIDDLHWDDDARTYCDATIDEYEEHVHVCHKGYISIFPFLTGMLGPDSPRLKAVLDLIGDPEELWSDYGIRSLSKKDQFYGTAENYWRSPIWVNINYLVLKNLYDIAIVSGPHKEQARELYSNLRKNLVENVFQEWKKTGFAWEQYNPETGNGQRTQHFTGWTSMVVKMMSMPDLPASAQKGHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC60</accession>
    <name>A0A8G1RC60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_410435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520894.1">
        <property type="nucleotide sequence ID" value="XM_025657481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC60"/>
    <dbReference type="GeneID" id="37160883"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="361" mass="40629" checksum="48D42FBC13B996CB" modified="2022-01-19" version="1">MAQNAVGRLFRSQNSTTLRQSIGSLTQTRNASRNAVPTFQQTSSPELDQALTRFREELFIPFGLGQDQRRLMFRQKYADRLEQEPVTANISEDEDFLLRPMDPQSRPTLKEAAEVISLMQSKNDWKNLVPFLSGLQMAKRHLKPSRLEWLVRKAGEHNAVNFVVEAAKQADRTGVKLNEVGIVQRLFFELHRKAQKAEFQGPEVAKAFNLATQLVGLMERPPHVQHDVMVDPKRKPFVAGTLLELSAARALSEFEGKDQGGLVRIYSSRVLGCWKMGNFASDVQDWRAVDKMLQENVPIYNGMKLALKVQGIANDKAVAPGLKNRLNELGQLIAKQKKSAPEEIQKNPSLGLAQAQLLHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCH1</accession>
    <name>A0A8G1RCH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_444479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521059.1">
        <property type="nucleotide sequence ID" value="XM_025659023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCH1"/>
    <dbReference type="GeneID" id="37162425"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="126" mass="14314" checksum="FBB75A87C324C7E1" modified="2022-01-19" version="1">MSSTTTTTTTTTSRAVDASTLSILSDYEIHHTGSETQPQPRVPRDAVPVSQPADWPSHYRRIPSYRPVNRNLSYEERSAGTSPVEYMFIQTMLHGVWLNASVARLWRFTGGRINDKIFHYEVGGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCQ4</accession>
    <name>A0A8G1RCQ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_4683</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520574.1">
        <property type="nucleotide sequence ID" value="XM_025662253.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37165655"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140278">
        <property type="term" value="P:mitotic division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11889">
        <property type="entry name" value="SH3_Cyk3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000168">
        <property type="entry name" value="SH3 domain protein (Cyk3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.30:FF:000005">
        <property type="entry name" value="SH3 domain protein (Cyk3), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035553">
        <property type="entry name" value="Cyk3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056409">
        <property type="entry name" value="Ig_CYK3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF2">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24584">
        <property type="entry name" value="Ig_CYK3_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="471"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="687"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="534"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="623"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH62652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1300" mass="142216" checksum="A8D7C35CC0248622" modified="2022-01-19" version="1">MAPAAPQLPTRFPCWCRAIYSWGGETKRDLGFVEGDLIECLNAGDGQWWMGRLRRDRRMMGLFPSNFVEVLREDFVPVQRSTSPMLPPASSPITNPTSAPKKQKTVFRKPFQAHKEALAPSGELSRSSTSSSPVTSTIPQTPPRDGSLSSRKVKPLRTPTTAVKHQSSLSRPVSRSRPLSRAMSPHPPVESDPQLSSTLPGTYMARSRPPSRGVSPHPPDPELHLPSIPPVQSAPRPGPPPRAVSPAPPPTIDYQLPSLPPMEVAIQRPASRGASPYPPDDVDLMPPQVPRHSISLHRPSSREISPLQLHEREDSPPPPPPPPHRVAVNRQPSIEPHVPTRLDMNDRFVTMSRTPSPAAHSEGRGHTPSPLRDAMEDVMTSLEDMGLPRGGQSPSPQPMFNNPWSPDAYDSFRETRPIQTSRRPLTSLGFDGDKEYQYHGSQAHRNSVYAHDPYMDGPPQLNNYVQRMESRLRQMQEQSQREAEDAQHSDEEAPPPPPRNVPYHARHNSIPAQYPVVRGRRSGQDLRGDLLNRSYTNKSSTTNSSSGVHSTSTTQTGSTERTSQSIMSGPSAGGFSATSAGSYARRGTTPAERPNTAVDTFRSRGFSDVSRVARPETPLTGVSYHSSHNTSRQGASSAIPWSSGEGGAEEPTAVFGGLSTPKAKKPGFFKKIFESAKTGAANARSSIAVGHNGGSSSPTKGRGISPIRALQSSRDSAREMGPGTSAIDWVQVRRDVNRASSPSRNERIERAERCQMMDHPVIYSVEELYETAEGDESIDGLPISEPTNFASVNLNLVDKSARFVNSLPPMTNPASLAHGYVCRPYKSDVQRLRAIFTWVSEKIAWDDPVEEIGIDLRRVLQTKRGSPQEVAYLVKEMCAAVGLHAEAINGFLKGPGEMFDLDGLSRPNHWWNSVLVDGEWRIMDCSLASPTNPRRNQFVTNNTSVAESWYFLARPLEICYTHVPLAPEEQHICPPISPDVLLTLPAACPPYFKLNMQFPDYDTSIIRIDGLEVMQIRLAVPPDVECAAEVEAPAFARDADGDFFESGEVVRKRALVQPDWVSGQKRITVKAILPGDEGQGTVKVYAGKKGLMHSSRDIPHPLALALPMLHSSDNPPYDFVLRHPTPHAQRHDLYIMQPQCAKLAVNNTFVFAVRQHPASPALSSGSNEAGVSGRVSPSVFTRPASALSMVSSSAGGSTVSGVSNEFSASTSAISSGRSMSGREKPAKLAIQSPSGKILRLTRKPEHMLSPHTGTHAFTDAPADGSVWETVIKIGERGVWRGLVLADRVARWCVFCEWECY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDH1</accession>
    <name>A0A8G1RDH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_493973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520621.1">
        <property type="nucleotide sequence ID" value="XM_025663849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDH1"/>
    <dbReference type="GeneID" id="37167251"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="LIPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="434" mass="47415" checksum="EAB5ECDE930F1754" modified="2022-01-19" version="1">MAKPRGGGGGGGGGGVYFSAQCQRAIEISNDIPVVSATSDDGGDTTSPVSTTRRRDTNCPVYDDYLIWDENEQPLNVTGYLHFGDSYAAGMGTGSTSWDSCRVGSNNYGKLLYNYLNDSSIPFSNYARSGDTTTGLINQVKKWKDTTSPNIGTLTVGGNDVGFSDIIRNCITWETFHDAEEFRAWCEQKKDKARSILSDTSSAGVRNKLKEAYLSILNASLNEDFMLYVTGYVGFFNYDTTICDLTTFDWWWTAYNPILPIREVVPFLKTALRKELDDLVNQMNQVIQDAIEDANTAYGSTRVTYVDMQPLFDTHRFCEEGVYEPSPNRGETFFFLTETAAVEAAEVVHMVSLGSIPIADAATCNTTLGTDPDPYAVAMCDASIAISTDPNAGAMAIMDTEPLDGQDYRNGVLGYITLGVDTTAIHNGTTEDPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1REJ2</accession>
    <name>A0A8G1REJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_455016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520877.1">
        <property type="nucleotide sequence ID" value="XM_025661359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1REJ2"/>
    <dbReference type="GeneID" id="37164761"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="74" mass="8402" checksum="29F87B0903B400CD" modified="2022-01-19" version="1">MDSPRLKAEEIPISTQSPSNNIVVPTLDAYVRTFAQAMIRMVVTPGREDSNWPAGEHARASAWPPKRQREHFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RHH2</accession>
    <name>A0A8G1RHH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Squalene synthase</fullName>
            <shortName evidence="15">SQS</shortName>
            <shortName evidence="15">SS</shortName>
            <ecNumber evidence="4 15">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_444696</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="4 15"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521337.1">
        <property type="nucleotide sequence ID" value="XM_025659085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RHH2"/>
    <dbReference type="GeneID" id="37162487"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000003">
        <property type="entry name" value="Farnesyl-diphosphate farnesyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 15 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH63415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="472" mass="54914" checksum="B9EA86B6013CB4C1" modified="2022-01-19" version="1">MGLASNAIYYTFHPSELRSIMQWKIWHSPVHERNENNETETEKACFKFLDLTSRSFSAVIKELHPELLMPVCVFYLTLRGLDTIEDDTSIPLETKEPLLRGFKDFLEQDGWTFNGNRPEEKDRELLVQFHNVITEFKKMKPAYQAIIKDITDKMGNGMADYCRKAAFDDASVITVEEYDLYCYYVAGLVGEGLTRLFVEAEFGNPALLERVRLHKSMGLFLQKTNIIRDIREDDDDGRRFWPKEIWSKHVTNFEDLFKPEHREAALNCSSEMVLNALEHVEDCLFYLAGLREQSVFNFCAIPQSMAIATLELCFRNPAIFERNIKITKGEACQLMFESTQNLRILCAAFRKYARKIHKKNTPKDPNFLKISLVCGRIEKWIETIFPSQNAEAAKRRITGELTEAEKKQAEEHAETRKDMYFMMGLMVVIVFITSIVMIFTAWLLGARFDLAWQELRSGNFRPPREIRAKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGW9</accession>
    <name>A0A8G1VGW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_506052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510651.1">
        <property type="nucleotide sequence ID" value="XM_025664364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGW9"/>
    <dbReference type="GeneID" id="37167766"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="179" mass="20772" checksum="4C29FD06FA45EA42" modified="2022-01-19" version="1" fragment="single">PEYIFPRDYLDNNCINLQHYLTTELFGYLLHPDIPPERESQNCRYRYRNRNRFYRFKSSSSAVSPARYVRLIIRLLSAQRATPSQYWPARMGYENSFPARVGRVSNIFHVRNVVSVLSDEEIVAIVSKLFKLLRPGGYFQWGEMDIHSLRIDEISGECSTAALEEIVRITRSADSSLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHH5</accession>
    <name>A0A8G1VHH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_381844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511298.1">
        <property type="nucleotide sequence ID" value="XM_025656441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHH5"/>
    <dbReference type="GeneID" id="37159843"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="51" mass="6241" checksum="5EB587503E8467BE" modified="2022-01-19" version="1" fragment="single">QWKKIKYKKTIYYIFNKIQASAVPVFLEIINLIKFYFIYKAGKICYIFIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHQ9</accession>
    <name>A0A8G1VHQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_503689</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511596.1">
        <property type="nucleotide sequence ID" value="XM_025664248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHQ9"/>
    <dbReference type="GeneID" id="37167650"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF32">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="9"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH53674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="426" mass="46699" checksum="300BB0639667FB1A" modified="2022-01-19" version="1" fragment="single">LTIRADFRVLPLLTIGFATYQIDRTNIASALTGGFASDIGISQDIINLGNQLMFLGVIVLEIPSNMVLQKVGPRRWISAQVCIFGVIAALQIFIRNKTGFLLTRSILGLAEAGYIPAAMYTLSTWYTKEELTKRIAVFFFGMFGGAAVSPLLGAALLKLDGKGGLHGWQWIFLLEGIWSVIIAIALFTLLPEREGNASETSDEESACKSQSWNGTTSNTIPVKVVWETLTNYTKWPHFLATACVFATWSPLTTYTPTIIMSLGFSRIQANALAAIGSLLTLPVIVFFASLSDWSRRRGMSVMLAIAVYLVALILLRVLQVHVYRWGRFGLWTTVNGLAVGYHPVHNAWIQVNCSSPGERSVIVMSATAGLMAGTQIFRHDDGLNGYPRGILIMIFLVLSGLILVAIQSAIYRSVNRSSKSRIVQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VI81</accession>
    <name>A0A8G1VI81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_430696</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510909.1">
        <property type="nucleotide sequence ID" value="XM_025658300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VI81"/>
    <dbReference type="GeneID" id="37161702"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH52987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="681" mass="77317" checksum="CA079CE3D300003F" modified="2022-01-19" version="1">MPQPQTYRRRVSVACEVCRRKRIKCDGAKPSCAGCLSYAENCEYKYDKEKRKPPTKQHIQALNARIEFLESQLAKYQPQESDTISTTTHQLQSQDDKVGNKDNSGAQSQSRDPIDDITDVLGGLSIGEGDQLRYFGSRSNLSFMERQGAKPFTFRQNPDQPLQPIGVDPEIREELLEIYWNWQNPWQYLVYQKVFLRSLEARLDDGYCTPLLLHSMLALAARYSDNPKVRTVPNDSSTAGDGFSQKAQALLFEEIKAPRVSTIVAAAHLSLFEMAKDNEPSGWIYLGMWIAIRMAYNLGLHINPHLWVSSGSMTPDEVELRSIAWWGCYMIEKLFTVGIGRPSIIIERDIQVDFPSNLADVEYGQWNGHSTSSASHPYLSYSITTFINTCQLLRLAARPLDDIYSPEYIVSFTEKKSIMTKTDIALTALYNNLPSVLRLPPTSSRPLPPHMYCFHMHFYTLVILLHRPFISIPSDNGPSRRSINESASTSWETCIKAAEKVTVLFRAYAKFFTLRKVSISVVDPARTAAFIHLFNMTSKDRQLRDKSRQLFLETLHYLEQMSIAWGWAKRSVRAVGLVSQKWRVHDIVKNKGQSPVESSLEYQDERQNHDSEIAGSVDAWLQDPLDSPLAVQAAEYSSPFFGGSLHMDQELFNPHNFLSAGDDAFLSGPLPDTDWEHGFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIS0</accession>
    <name>A0A8G1VIS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="12">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_452060</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases L-arabinose from arabinoxylan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="12"/>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512558.1">
        <property type="nucleotide sequence ID" value="XM_025660734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIS0"/>
    <dbReference type="GeneID" id="37164136"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF1">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH54636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="332" mass="35969" checksum="EA64493E5B77E132" modified="2022-01-19" version="1">MKFFNAKGSLLSSGIYLIALTPFVNAKCSLPSSYSWSSTDALATPKSGWTALKDFTDVVSDGKHIVYASTTDEAGNYGSMTFGAFSEWSNMASASQTATPFNAVAPTLFYFKPKSIWVLAYQWGSSTFTYRTSQDPTNVNGWSSEQALFTGKLSDSSTGAIDQTVIGDDTNMYLFFAGDNGKIYRSSMSINEFPGSFGSQYEEILSGATNDLFEAVQVYTVDGGEGNSKYLMIVEAIGSTGHRYFRSFTASSLGGEWTAQAASEDKPFAGKANSGATWTEDISHGDLVRNNPDQTMTVDPCNLQLLYQGHDPNSSGDYNLLPWKPGVLTLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIS6</accession>
    <name>A0A8G1VIS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CBS and PB1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_378135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512796.1">
        <property type="nucleotide sequence ID" value="XM_025656287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIS6"/>
    <dbReference type="GeneID" id="37159689"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17781">
        <property type="entry name" value="CBS_pair_MUG70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17782">
        <property type="entry name" value="CBS_pair_MUG70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06409">
        <property type="entry name" value="PB1_MUG70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN DDB_G0289609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="104"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="171"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="274"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="340"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="575"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="577"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH54874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="662" mass="71923" checksum="DBA40976D1A9355F" modified="2022-01-19" version="1">MSSTPTFKGTISHKTVGRGRLPDFDSHIPRPRPETSSTTHTPQTASSDIGSSTMSAASSRQRQNQSKRDEAIRRKLEADLNKKRHAPARANRSRKAPPGTVLALKPSQALQIKPNTSIAEAAQLMAAKREDCVLVTDDDDRIAGIFTAKDLAFRVVGTGLKAREITVSEIMTKNPLCARTDTSATDALDLMVRKGFRHLPVMDENQDISGVLDITKCFYDAMEKLERAYSSSRKLYDALEGVQTELGSSQPQQIIQYVEALRHKMSGPTLETVLDGMPPTTVSVRTTVKDAAALMREHHTTALLVQDQGSITGIFTSKDIVLRVIAPGLDPSTCSVVRVMTPHPDFAPSDMSIQAALRKMHDGHYLNLPVMNDAGEIVGMVDVLKLTYATLEQINTMQSHDDEGPAWNKFWLSMDHESDSMVSGSQQPAQRSVLSPESPKASYDARDSVLPNESASHHGGDEHSEYHVDPHHGEHVPFPFKFKAPSGRVHRVNVFPSAGIAELVAQVSAKLGPEADAVGGVPSCDEGKLSNTGYALSYLDNEGDTVSITTDQDLADAVSLARQSHRDKVDLFVHDPTQPPIPATVEPQPVPARPIEEKSPISEDRSEEESVVAKPRAQSFPVHQPEEQFIAGVPNDLLLPGAIVTLAAVIAGVFILSRATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIY2</accession>
    <name>A0A8G1VIY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_101932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512753.1">
        <property type="nucleotide sequence ID" value="XM_025653782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIY2"/>
    <dbReference type="GeneID" id="37157184"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="161" mass="17465" checksum="520207BF8430CEB4" modified="2022-01-19" version="1">MAACRTYSFSPHFTDQKEYRPNRTSSPPLRRSQGSWWMMAPRRTSTTTEGLFGYDTDTHTHTYNSPSSSSIPVGVIGPSGSINPPRKPILRLDTVFDVGCLACPLAIPPFLYAAIAHGRAIAIINNSNSNPKQRSGTVFVGADRKAHLTQPAPEAKHSAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJP9</accession>
    <name>A0A8G1VJP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_425533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513593.1">
        <property type="nucleotide sequence ID" value="XM_025658079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJP9"/>
    <dbReference type="GeneID" id="37161481"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132:SF1">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="378" mass="41774" checksum="771502B6176A7983" modified="2022-01-19" version="1">MPPNTGKAIGDPSDDAYVAQVLAREARDSSLKYSAHGLEAYMPKRPTGAAPKPNTRFLRHIIRETDNHNTALKRKEEREARERMRQLRNQASSSSANDTNRDQRRSRLEGNIGVALHRRREANRIGADGGVTLKIPMTTGIDPREGVVATDLILVQGVDPRNAAGMLILAAIADDIATAMSRHDHVRGPQEHLTGAGLEIATAGVTAEETPLDDESDPLEDLVGPLPAKDNDHGYSAPIRSRGRGAYKPNMSNIDAHFAPDYDPTTDVHLEDDDGQAGSRPTRRPVAGLMTGDDDWELSLEALRDRAKWKQRGEERLREAGFSNEFVDRWKSNTTSTPGDDSEGRLEDVKWSKKGEGREWDRGKFVDQDGHIDVKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK17</accession>
    <name>A0A8G1VK17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_382014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511210.1">
        <property type="nucleotide sequence ID" value="XM_025656450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK17"/>
    <dbReference type="GeneID" id="37159852"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="191"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="701" mass="80421" checksum="A22B675FE45DCC2D" modified="2022-01-19" version="1">MALQDAGRAGCTFCKTIWAHHCHFWSRKSYSDVFSANFFACHEWDTCACRIYKGPLHFVIHKFINEWPSNSPRLLILGMANSEKSEIPDLIYSRSRVIAEFEIRIAKSAEIPEEDTHLIECLVRNALPFDLGSKRCLSLAAKWLRNCHKKHMQCDMLEDRPPFFPTRVIDVGKPNRRPHLHVSRIGETAKWMALSYCWGGDSRFTLNSSSFDDLRSGWSLAGFPATLRDAVLVTRALGIRYLWVDSLCIFQDDPSDWEAEASKMSSVYKHAAVTIAATSARTAEDGFLDKRAPYFSSHFPWRRQCHQGSGSVQHVSRVDPVVFQSHRQFYHQEPLRHSRWATRGWTLQEELLSKRLLYYTEEEMIWRCYAGKAREPAQKVNDGEDVYPEPLWFTLDEPDGNYAPQPAYESWIRLLEDYAARSLSFDKDRLPAIGALAESFHAHMKEQYCAGLWRGDILFGLLWSIQRCHGTEISAPTSVSSKERRPSWSWVGADGCAKLKWPTPDFRYCMTYLAIVAHCQIYRKSHDIFGRIEGAELVLNAPYRHVCLRPGSYSKSRWNPVSLAQRMLTQLGPLASTKELAQIALGRPEYLESTETSGSVTVLSSSTEFTLIQIAKADHWYTPTLYLLILQPLTRQVAQSEEMRRYRRAGLLRLCSKRGGLQSDDFRAAESVEGTLTERLEDAAYWEVIREEWPVGSFLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKJ8</accession>
    <name>A0A8G1VKJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BAR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_469511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514776.1">
        <property type="nucleotide sequence ID" value="XM_025662336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKJ8"/>
    <dbReference type="GeneID" id="37165738"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="2">
        <location>
            <begin position="15"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="431" mass="48979" checksum="1F306801942FEADE" modified="2022-01-19" version="1">MNVNRKFDRFKQWAGERMGGEAKTTLSDDFKAMETEMNVRHEGIDRIHKATGSYIKSISKRSEGDDKEKTLPIAHLGSSMVGHGEDFDANSDYGRCMTMLGRAEERLARLQDAYISQVNAGWLESLEHSLTQMKEYQAARKKLDSRRLAYDTSLSKMEKAKREDFRVEEELRTQKVKYEEANDDVSRRMQDIKDSEVDGVANLEAFLEAQLDYHERCRDVLLQLKYEWPNRAQPPSSRRPGRPRSNTAHSYHERYEPLHEETDNTADLRPIIRSTRASSIEPSAREVYPPDAYSQRPVLNRTSTFEGPTQLRQEQSPGTYQWPSRAASDNYIGRRNSVQSRTMGRPYVDPYMEQSEDASPVSGTSPERTYMGRNPSPVSSYGGAVSRKSSSTTLNGTPLNKKAPPPPPPRSKKPAPPPPPMKRPILSAGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMG3</accession>
    <name>A0A8G1VMG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_370279</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516741.1">
        <property type="nucleotide sequence ID" value="XM_025655954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMG3"/>
    <dbReference type="GeneID" id="37159356"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF23">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="248"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="685"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="731"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="693"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="750" mass="84472" checksum="BFB592B2CC453895" modified="2022-01-19" version="1">MRSDVVCVYDDRRTKPGLRAGAVDQLYRRVETLENMFLGQEMLWQQMWQSLFPNTEPPRSLAKGTTAATTLAERREQLKASVLDSANVATKRTSTEANTDDSAPPECAPPHSKRTRVENSLVYHAVALQSESRVASPLPDAVLTELVDFYFTNIHPWIPILHVKKFRERMRSPEERTHINCILHAIVSVCARFSQNKQYGDTLDMKEIAKKSRQEVILQSTETFSVENLQALVIVAFETINRGRGPSSWSIIGSMAGTVEQLQLGVEEDDLYRVKGMGERLIRRMVFLTPSRSWSEAEERRRVFWAVFLMDRFCSVSTGWKISLRNADVKRRLPCEGALWEKEQEVCTPYFGISDIKNTSLSNSHSATIDGCEEQAIGAFAYIIEATESLALVTNFYLHHAFLINDASKARLWLVKFKELDLRLIQWKIHLPPKWREACVLNEQRVMDPNLTLAHITHNTAVILLHQGIAYPPAHWQKCPIKLPSASSADTCLEAASEIATIADQFLSFSPIFTNPQFSFCLFIAGRTLLAHARHNRVPPSPALNTLIGNLMEISQRWTRQHDGSQAPQEDSLAFKFATRLIEAQQNRACVSRPSLDIRTTAYSDESKEEMYKDLMGTKPDDPPDYESLGEPLQLAPFPSQQSTGCSFDPFSLAFPPLPPAFQQDFSPTGLDPFSFYNMQLPSDSSISSPLETRSHESGSRHDSESSMNNLMPTDISHLFDVTSSPGQRISYYGNTRGLTKDSATDGIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMN4</accession>
    <name>A0A8G1VMN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_459158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515857.1">
        <property type="nucleotide sequence ID" value="XM_025661632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMN4"/>
    <dbReference type="SMR" id="A0A8G1VMN4"/>
    <dbReference type="GeneID" id="37165034"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034968293" description="Hydrophobin" evidence="2">
        <location>
            <begin position="18"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="146" mass="14296" checksum="7BA651D4AA3C889D" modified="2022-01-19" version="1">MKFTAAAALALATVVVAQPSVRGRAVNHIPAPAGMTVSQGADSCGSGNQLSCCNKATYAGDSTDIDSGLLSGLLSGLIGSGSGSQGIGLADDCSPLDLQALDLVGLQNLLNDQCEQTAACCQGSGSDTEGDLIGLGLPCIALGSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN48</accession>
    <name>A0A8G1VN48_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_468117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516322.1">
        <property type="nucleotide sequence ID" value="XM_025662234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN48"/>
    <dbReference type="GeneID" id="37165636"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="35653" checksum="C65B1AB98915A454" modified="2022-01-19" version="1">MSRHEPPPQMDPIAPTSSTSNTVTLRPMPQLEHLWTPEDDWTGVSDRIHRRRLQNRLNQRAYRKKHKATMGGSSSSTSTTQTQTLISHPSTTIHHHHHPTSSHSTPEEEEEDNHHCPLAPSNINIPHIHKTLTTLAIQSYLTNRPRLEHLLSLSRLNVHRAINDNIRLLGMAPAHLRPDDALSIFNIPSPFPNIDLSTLPESLRPTPLQRLIPHHPWLDFFPFPEMRDRLIVAAATGSLDEDELCRDLMAFWDTRNSGATLVVWGVPWDPRNWEVTEAFLGKWRWVVLGLGGLRRSTDYWRGRRGEGRLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNF9</accession>
    <name>A0A8G1VNF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_439185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514585.1">
        <property type="nucleotide sequence ID" value="XM_025658701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNF9"/>
    <dbReference type="GeneID" id="37162103"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF4">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034438503" evidence="4">
        <location>
            <begin position="21"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="496"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="799"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="799"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="850"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH56663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="936" mass="96944" checksum="33C8A218318C435F" modified="2022-01-19" version="1">MRSVLLSGVAALSYALGVSANAYNTSAYTDSASGIEFQRWCDTDDTGFCFGIALPEETTGTDFIGQMAVPLSSSKGWGGVSMSGSMTNVLLIAAWPDGDSAVGTLREATSYVSPSVYSGDASIEEIPDGTSVNSTYLTYTFLCKGCIIGQPTTFDANSTSYYFGWALSASNPTTPSSASSKMPYHAAGYGGFEVQLAEARSSKYSTWASKAVATQSTATSASASSSASASASASPSASVAATVSNTTYDYIVVGGGAAGLVAAERLAETKKSVLLIERGVAPTVELGATDSLSWNSSLTAYDLPALGTYIQGSDYISQYLCDDTAGMAGCVLGGGTIVNAMSFIYPQEADFDDKWPTGWKWKDVKAAAERFYARNPGSTLPSADGKRYDQGMYTVLSSFLKGLGWKSVDSQEQPNEKHMVYSYPSWDVGNGIRAGPVRSYLPLVQDADNFHMSLNTKVRRVVRRGGRITGVEVENSSGGIEIINVRAGGKVVLAAGSMSTPRILFNSGIGPSEQIKTVQSGSTGITLPPSAEWIDLPVGDNLRDHPMFTVTVNTNSNFTHFDTESAVSGATAPIRKLYSEGSGVMTQGGHRLQFWTSNVGTDGVTRFYQASCSTTKDGVITMKLYLTHGATSTGVLGIDSTGSTTIETSPYLNTAADKEALTRFLNGLIADMKNSTAGFSIEGTATAASILNQLTAGDHYVGTAKMGVDDGREANGTSVVDLNTKVYGTENLYIVDGSIHPDLPTGNSQAIIQIAAEAAVARIIAQGTSATSASASASVSVAASTQAAYVSTTSEAAAATETETEAVTTTGAVTATAVPTSGTISSTTGSSSSSSSAGSSSESESSTGADDNEGDDDDDDDDDEYDCDDEDDEDEDDSSSGAIESVTAKVAVASTAAADSGASTTTVWVTSTAWTTTTDMVVATSTSTVTVWPTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNS0</accession>
    <name>A0A8G1VNS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_518797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516804.1">
        <property type="nucleotide sequence ID" value="XM_025664997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNS0"/>
    <dbReference type="GeneID" id="37168399"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="84" mass="9286" checksum="4984004FEF444B2A" modified="2022-01-19" version="1">MTSERRPSGAYHLTGSQLVEKVDDLSSGGGWEELNRRAHHADTGDSQQQSQQQQSGSKAAPDRSQSFRPYNPSKDQSDDLLPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNV7</accession>
    <name>A0A8G1VNV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribonuclease P complex subunit Pop1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_418454</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517132.1">
        <property type="nucleotide sequence ID" value="XM_025657817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNV7"/>
    <dbReference type="GeneID" id="37161219"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="56"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="6">
        <location>
            <begin position="554"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="7">
        <location>
            <begin position="728"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="666"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="673"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="688"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH59210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="880" mass="97778" checksum="5EB7679A2C37C29F" modified="2022-01-19" version="1">MASHPPKRKPAAPNNNFSAAAAAARKRQKTFDARSLAVQAADAALSASGELDVAAYVEAREYEIRSLESGIQRSKNALTSRAFQKVPRSLRRRTASHNVKRVPKRLRARARREMIEDNTPTVSSRTRKPTEQMRIRLETARRLQNLNAKTKAKRAAVKAQRDKEVRKSLEESGSHAYEIAPRVPKIKKNKLSRPNPPEARFKKRQQCKTWLPTHMFHAKRAHMATSKDPLWRFAVPLSPTEKSYRPTHRARGSRGAVAWDMSYLATVQLEGSVGALEGVLRAVGVEGEKAWGVKGRKWRAGTRGLRAWVYEWEEEKRPIAPVTLVWCAEVKGEDVEMVDADESGKQKKGKKGWRKVFVRVHPSAFLQLWNALLGVSKKQNPPVMVEDLRFEIGSIEITGPGATEALLASFKPVAVDGKDVAADSPEATWTSLVGVTNPASLPQDAILGFSVSDPRLDFPPKALKPSSSEEEMQRLAILLSSWTPDNTQTAPALFDRRARLAAARQLPSQKAINRRRTEAGPGVRPPAKDTDPKIPVMVLASRPTHSKSSSAPGTWTVLLPWKCVLPFWYSLMYYPLSSGGNPRFGGLKEQQQLSFESGEPWFPGDFPGTRAGWEWGLRETEEAKREWERRPKGRRTEFESIDLRNGQKGEIGRGWACDWERLIQGAPEASNTTDKEQPSETETKSDDTTNSQDNNTSTTLPPLNIHQLSTTEATRALTDPSTTINTSALATVKLTLLNRGTPTPRARIYRLPTTDRELRQEWLTLSSKQPYDGLRDELQKKQSRSTANLGPEDVQQQLAASLITPSAGDDVRQKHLPVPTEEDLIGFVTTGNYNLAEGKGTGIGSVLLSKVQKGKASGRNMCIIRSAGETVARVGFWELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP16</accession>
    <name>A0A8G1VP16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_520740</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515215.1">
        <property type="nucleotide sequence ID" value="XM_025665155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP16"/>
    <dbReference type="GeneID" id="37168557"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF14">
        <property type="entry name" value="BETA-GLUCOSIDASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="11">
        <location>
            <begin position="30"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH57293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="156" mass="16907" checksum="88A4D88E09C80FC5" modified="2022-01-19" version="1">MATLSNTDKIRLISGQSVPSINFEPYTTNDGSQGLESFFCVTSFSEPSAMAQTWDPELIKASFHAISQEFYGKGYTMINGPTVGPQGRTPWGGRLVETLGQDVYLAGIACVHATEGIREAGIIPCGKHFLLNEQETNRSEVYWSSNAVTVPLNNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP50</accession>
    <name>A0A8G1VP50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipase/serine esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_392130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518348.1">
        <property type="nucleotide sequence ID" value="XM_025656834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP50"/>
    <dbReference type="GeneID" id="37160236"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000223">
        <property type="entry name" value="Lipase/serine esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF65">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="5">
        <location>
            <begin position="14"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="344"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH60426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="466" mass="52505" checksum="FFD08D1263CE387B" modified="2022-01-19" version="1">MELDNGHPPTETSRNADHLCVFVHGLWGNPSHLDYVTSSLRERYSEDRLHILSAKRNAGNFTYDGIEVGGERVAHEVEEALEELAAAGHHIKKLSMVGYSLGGLVARYALGLLYSRGWLDKLEPVNFTTFASPHVGVRNPQKGAWGFLWNNVGPHTISISGKQLFMIDTFRDSGKPLLSVLADPDSIFIKALKKFRHRTVYANVVNDRSTIYYTTAISTTNPFHEPDNVRINYVKGYDPVVIDSDRHILPSDKKRIESLSLVPQAQQQLMTYLTEAPFQLLFTTILFIGFPIFLINSAIQTVRSQRRIRLHEEGPMGTVFGRYRVPVVVQGVQHAVEEAFEHAAADQDPDYLDESKDETKQVASARRARSSESKSNALIREDSPDSASEPLLARESQEPQEFPTLALTPDQFAIIESLNSVGFRKHPVYIHNHRHSHAAIIVRMPKPGFDEGKIVIKHWLDQVFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ54</accession>
    <name>A0A8G1VQ54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_512480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516325.1">
        <property type="nucleotide sequence ID" value="XM_025664655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ54"/>
    <dbReference type="GeneID" id="37168057"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041127">
        <property type="entry name" value="PET_hydrolase/cutinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12740">
        <property type="entry name" value="PETase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034285233" evidence="2">
        <location>
            <begin position="20"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="PET hydrolase/cutinase-like" evidence="3">
        <location>
            <begin position="51"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH58403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="359" mass="39280" checksum="CA11DF0628278F68" modified="2022-01-19" version="1">MKLPALLLAPILHTICTTAQNLSYGADNFYRSNLVTLQPVTFPTQYQTLIAGNLFIPNNLTTTIPSPAIIVGHPMGAVKEQSANLYATKMAERGYITLSIDLPFWGSSTGTPRNAVSPDLYTEAFSAAVDYLGSNTTTITTIPSIPHPITINRNRIGVIGICASGGFALSAAKIDPRIKAIVTASMYDMGTVNRQGLRHSQNLTQRQEVIASAALQRWPEYEHPGGATNPIGYTGGTPNTLTANASAVDREFYDFYRTVRGEFTPLGSTPELTTHPTVTSNLKFMNFYPLQDLDVIAPRPVLFISGDQAHSREFSENAYRGASEPKELLWVPGAGHVDLYDRVELIPWERIEGFFGRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQB6</accession>
    <name>A0A8G1VQB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_509402</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518499.1">
        <property type="nucleotide sequence ID" value="XM_025664494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQB6"/>
    <dbReference type="GeneID" id="37167896"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF48">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="89"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH60577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="535" mass="59504" checksum="AD6A17C574787D61" modified="2022-01-19" version="1">MDKTYHSNYSNSHVSRALTSEADPLDLPYRQVTENANMEEYTTETTTGEIIKPVRSAATGKTEEWKLVTFSVDDPENPKNWSKAFKWYCTMVVSFTCFVVAFASSVITADIEGPAEQFGVSREVSLVVVTVFVIGFGVGPMAFAPLSEMVGRRMIYASTLLLAVIFIIPCAVAPNIGTLIVCRAIDGIAFSAPMTLVGGTLADLWKNEERGVPMAAFSASPFIGPAIGPLAGGYLADATNWKWLYWLQLILAFVAWVLITFTVPETYAPTLLKRRAKKLRKQEDDPSYVTETELDSRPMGEKLRVFLFRPFQLLFLEPIVLFIALYMSVLYGLLYMFFVAYPVVYQSGKGWSAGSTGLMFIPLAIGVLMSAACAPFVNKHYLSLYAKYGGKPPAEARLIPMMFSCWLIPIGLFIFAWTSYPTIHWIGPAIGGWPVGFGFIFLYNSANNYLVDTYQHQAASALAAKTFLRSMWGASTVLFTEQMYNRLGYQWASSLLAFIALACCAIPYVFYLKGASIRRFSRYAFSDDEENGEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQE0</accession>
    <name>A0A8G1VQE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="11">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_458833</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="11"/>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516595.1">
        <property type="nucleotide sequence ID" value="XM_025661608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQE0"/>
    <dbReference type="GeneID" id="37165010"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11 13" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="12">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH58673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="692" mass="77500" checksum="8223214F5D197E86" modified="2022-01-19" version="1">MVKPQIYQLSVAAAFDGLRPQEKLYAHHMAKAAWNGTRIILRQVSPEANGIFDFIMALYHSCDGNWEQLATETGVSVQELENFLDYAATFLSNVGNYFGSGDQKFTPNVSKETLTSLTSVSSSASKLFGQIKEPMISPLPSSLGHPGPFTQSSYYLGEDCLESSEDIATISTISKLMEAQSILPENTRLKAYQDSDTRCYDIMQASVVEEKVALGVFDVSGASDKRAFLLKGDHKEELKRVCDCLQQAIPYAPNAAQVEMLQQIIDSFETGSLEAYRESLRIWVNDKAPPVETVIGFVEPYRDPLGVRAEFEGIVGIPDAAETKILNTLATKANQLVYKLPWVEGTGDSKGPYEKELFEPPDFSSINSLVYCSSIIFPGINLPNYNDLRQDTGYKNIIFSNRMVSESSRSRGLHMVDASEQDTFKKHRFHAYYIWVVLHEILGHGTGRFLTESSDGVLNFNMENPPLDPFTGKLVESWYRVGQTWTGVFNDLATTVDECRAELVGAYLIDDLEILSIFGYTGQSEVKPDDIAYNMYLQLGVDGLRGLENYDPTTQKWGQAHSRAHYAMFRHLLCDSGGLYSVTSNLEKNSLTVKVDRSRVISHGKPSLGRMLLKLHIYRCTADVSNCRRFYEDLSHVDEQALKWRAIVVSKKDPPLVFSQANTYLIGDDVKIKEYEPTARGVVQSWAERSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQM7</accession>
    <name>A0A8G1VQM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="4 13">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_446182</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="4 13"/>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518947.1">
        <property type="nucleotide sequence ID" value="XM_025659449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQM7"/>
    <dbReference type="SMR" id="A0A8G1VQM7"/>
    <dbReference type="GeneID" id="37162851"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="9 13 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="14">
        <location>
            <begin position="24"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH61025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="211" mass="23640" checksum="C97A951582DC2A23" modified="2022-01-19" version="1">MATNITYHASGLTRTERNTLRSQRGLTIWLTGLSASGKSTLAVELEHQLVRDRGVHAYRLDGDNIRFGLNKDLGFSEADRNENIRRIAEVAKLFADSSAIAITSFISPYRKDRDTARQLHEVPTPGEETGLPFVEVYVDVPVEVAEQRDPKGLYKKAREGVIKEFTGISAPYEAPVKPEVHVKNHEVPVQEAVAQIIRYLDEQGYLPAKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQP1</accession>
    <name>A0A8G1VQP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_447965</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516895.1">
        <property type="nucleotide sequence ID" value="XM_025659824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQP1"/>
    <dbReference type="GeneID" id="37163226"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="9">
        <location>
            <begin position="7"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH58973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="270" mass="29033" checksum="99171A712C480D20" modified="2022-01-19" version="1">MPPTPRPLTLIVATTPIPTPTPTPTPTSTTESSSSSTPIRLGIGHSGTLPWPRIKTDMSFFARVTSRPPVPGTTNAIIMGRKTYDSVPAHLRPLAKRISTIITRDVEGLKPRVAREVEDRKAKLAASAAASTSGGNGNAVQPATDAIVCGGLDEALQELETRYGDEGKLGKVFVIGGAEIYGAVLAAAKGGGPVRIVMTNVEKKGYAEGDRGEVFECDTFFPVDEELFGEKEGWRRVTPEEVTEWVGEEVTGRWIEEGDVRVQMVGYERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQU2</accession>
    <name>A0A8G1VQU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_435514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519142.1">
        <property type="nucleotide sequence ID" value="XM_025658530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQU2"/>
    <dbReference type="GeneID" id="37161932"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH61220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="287" mass="30989" checksum="19FF5FEF3995577B" modified="2022-01-19" version="1">MSTDRKTVLITGCSDGGIGAALAETFHDHRYHVFATVRTPSKAPKSLTISPNATILTLDVLDSSSIANAVEKVTKVTGGKLDVLVNNSGGSIILPAMDTSIEEGKKLFDLNFWAPFAVTQAFAPLLIRSKGCVVNNTSVNGALPFVFMSMYNSSKAAFMSASETWRMELAPLGVRTITLMTGGVKTKFFDNYVQRQVPETSYYIGAKDAIQKMGDGSLQDSGVDRYAYASKVVQAVERRASGKLWVGGGAVPAKWALWLLPQWGVDLMMRKMFPVFETIGGGLKKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR71</accession>
    <name>A0A8G1VR71_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_243529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517405.1">
        <property type="nucleotide sequence ID" value="XM_025654862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR71"/>
    <dbReference type="GeneID" id="37158264"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034149457" evidence="1">
        <location>
            <begin position="19"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="65" mass="7251" checksum="CA6A825DEC7CCA9A" modified="2022-01-19" version="1">MRFSLFMAISAFAGYVAAASIPLEQRSYSCSVEGEYCCTWEGCKDCCTYCELSIDDAQGHCAYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRC0</accession>
    <name>A0A8G1VRC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tat pathway signal sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_412367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519667.1">
        <property type="nucleotide sequence ID" value="XM_025657568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRC0"/>
    <dbReference type="GeneID" id="37160970"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08588">
        <property type="entry name" value="PI-PLCc_At5g67130_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034722975" evidence="1">
        <location>
            <begin position="22"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="464" mass="50852" checksum="F0FE2CBC8BA86A00" modified="2022-01-19" version="1">MMLAVAYLWILLLLRGIHVGAKSTTSMREAEVTTITDDTSTASVSSTHSGIDSDSFSVVTTETAVVVPTGSYLSYTTTITVGDSVSQTTFTTTTAANTTISTNGTTTATTTTDTNVVVTGTRNSSSTATSTATTPANLQPCNGYTEFCSRQYSNITMVTAHNSPFVKKNNIAANQMYNVKTQLEDGVRMLSFEAHYYEDDIYLCHTSCDLLNMGTLEDYLTTVTDWIKDNPYDVVTILIVNSDYVSPWNFTAPIENSGLIDYVYEPWKIPMSLDDWPTLSEMIMGGKRAVVFMDYQANQTAIPYILDEFTQMWETPFSPLNTSFPCTVQRPPGITAAQAEERMYMINHNLNLEIVFEGIDILVPDSAQINETNAVSGYGSLGLMANNCRAKWDRPPNFLLVDYYNDGNFQGSVFEVAAQMNNVTYNGKCCGGSSSAASRIVDVPYTWLSAFVAMGVGLFTLFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRR1</accession>
    <name>A0A8G1VRR1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Velvet complex subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_335493</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the velvet family. VelB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520044.1">
        <property type="nucleotide sequence ID" value="XM_025655445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRR1"/>
    <dbReference type="GeneID" id="37158847"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3960:FF:000002">
        <property type="entry name" value="VeA-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="11">
        <location>
            <begin position="56"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH62122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="360" mass="38678" checksum="92B4889B3EB32D4B" modified="2022-01-19" version="1" fragment="single">MYALDDRTHTAPPPPPPLSMDRIPPPSSSYPTPGSAGVASAGGLPPSSHLAPLSTVHENRIWSLQVVQQPVRARMCGFGDKDRRPITPPPCIRLVVRDAQTEKEIDINEIDTSFYVLMVDLWNAEGTSEVNLVKHSATSPSISTAMSSSYPPPPHSVSPSYPPYAQNAYGQPVGYPQMNNYYGGNPQLQYQNPYGANPQAPYYQPYYAGGHMPQANISPAQPVASGPGGMFTRNLIGSLSASAFRLTDPENKIGVWFILQDLSVRTEGSFRLKMSFVNVGSQSGDSPNGVSVINHGSAPVLASVFSEPFHVFSAKKFPGVIESTPLSKCFALQGIKIPIRKDGVKGSRGRHSDGDDAGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VS21</accession>
    <name>A0A8G1VS21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_495395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521423.1">
        <property type="nucleotide sequence ID" value="XM_025663913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VS21"/>
    <dbReference type="GeneID" id="37167315"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040:SF1">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="9"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="236" mass="26787" checksum="5D930AD465554DF7" modified="2022-01-19" version="1">MDTPVTPPSIYIDLEGMNLGREGRISTIQIFLYPHIHVYLVDIHTLGATAFNHATTTGTTLRSILESFMIPKVFFDVRNDSAAMFHQYQVELAGVHDLQVMEMGIRPHPGKYLAGLRKCISRDVPMTQADKANWSATKEIGKTLFSPQHGGSFEVFEARPLPEEIVQYYVQDVLFLPKMWQIYNQALTPTSRERVEIEVKNRVRLSQSSQFIGKGSHLVLAPQLWETVPECPSSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSI0</accession>
    <name>A0A8G1VSI0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL/TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_13755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520869.1">
        <property type="nucleotide sequence ID" value="XM_025654049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSI0"/>
    <dbReference type="GeneID" id="37157451"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF3">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="128"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="429" mass="48021" checksum="1E4E333675470E8D" modified="2022-01-19" version="1">MPFWGTKSSQPAAESDAKSTHDATDPINDPVASASQAAGTAWLAGHLHHLTDDQEKKLEEFKKLCEEKGYYKPERDGEKASHDDATMLRFLRARKFDVDGAWGQFKDTEDWRRDNAIESLYENIDVDSYDAARRMYPQWTGRRDRRGIPVYVFEIKHLNSKNMAAYNETMSSSTTAETHQSSTVPQRLLRLFALYENLLNFVMPLCSKLPRPNPETPIVTSTNIVDVSGVGLKQFWNLKGHMQDASVLATAHYPETLDRIFIIGAPSFFPTVWGWIKRWFDPGTTSKIFILSAAEVKPTLTAFMDPSSIPKQYGGDLDWQWGDMPYLDDEARKVVGALETPPAEGETKPDFIKGPVLFKDDHVEVLGKVNGESRKSNIPVGATPPAQSNTTSPVQVEKPTEQEQTSENEKVPLQEPAPASETETQTVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSU3</accession>
    <name>A0A8G1VSU3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS peptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_517370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519085.1">
        <property type="nucleotide sequence ID" value="XM_025664901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSU3"/>
    <dbReference type="GeneID" id="37168303"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH61163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="611" mass="68153" checksum="D83AF549A9E506CF" modified="2022-01-19" version="1">MSDPVGADDLVYVAQAHAPQKEIQAVEEKKESHLPINEKETAVVSAVPSIHDVHDDGREYPTEEEERTLRRVSDTVSWTAYTVAFVELCERFSYYGTTAVYVNFIQQPLPAGSTTGAGYSGQSGALGQGERTSTALTTFNTFWCYVMPILGAWIADEYWGRMRTIQVSIGFAMLGHIIIIISSIPPVIVHANGALACFAVGLVIFGIGVGGFKSNISPLIAEQYKETKLFIKTIPKTGERVIVDPAQTITRIFLYFYFMINVGSLIGSVAMVYAEKYVGYWLAFLLPTIMFGICPIVLFFCRKRYTVTPPTGSVVTKAFQLWSLALRGQWSWNPVTFYHRCKSTEFWDSVKPSRLANKPSWMTFDDNWVEEVRRAVKACAVFAWYPLYWLAYGQMTNNLTSQAATMQLHGVPNDIINNLDPLALIIFIPIMDQFVYPGLRKMGFHFTPIKRIYAGYLLASASMIAAAVTQYYIYKLSPCGNHPSTCDEAAPINVWVQAVPYVLIAFSEIFASITGYEYAYTKAPKNMKSLVQSLYLFMNAISSAIQQGLTALSTDPLLIWNYGFVAVLAFVGGNLFFLCNLKLDKEEDELNNIEESAYLGRNAGEPGKIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSX9</accession>
    <name>A0A8G1VSX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin cytoskeleton-regulatory complex protein END3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Actin cytoskeleton-regulatory complex protein end3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoskeletal adapter protein sagA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Endocytosis protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BO85DRAFT_192494</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the END3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519190.1">
        <property type="nucleotide sequence ID" value="XM_025654438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSX9"/>
    <dbReference type="GeneID" id="37157840"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000323">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein end3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000339">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein END3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025604">
        <property type="entry name" value="End3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12761">
        <property type="entry name" value="End3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15 22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="23">
        <location>
            <begin position="10"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="24">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="23">
        <location>
            <begin position="139"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="285"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RAH61268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="404" mass="46219" checksum="1893D6D8BA6DABBD" modified="2022-01-19" version="1">MSTKKIEQWEIERYWEIFASLAGGQPRLNNSQAASVLRNSRLRDDQLEKVWDLADVDGDGELDFEEFCVAMRLVFDLVNGELQAVPNVLPDWLVPESKAHLVHATRALSGRPEQFERIEDEDDTPGLKDGFEWYMNPSDKSKYEEIYLANKNHRGEISFESLQPLYDSLDVPDTDIRSAWNLVNPSASPTINKDATLAFLHMLNYRHEGFRIPRAIPASLRASFENNQIDYQVDNARPAQKWGASGDTETLTGKKAKFGDTYLSRLGAGGKTSYTPKGTDFSDTIQDEEWEKVRLRRELAEIESKLDSARKASEGRRDRPRNDGRPNWVLIKKEALQLLEYKERELRELREGAGRSKDGQNVERLRDDVKTVGEQVEGLKSHLAQRREVLSDLRAQVEEAKLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VTX7</accession>
    <name>A0A8G1VTX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_502060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520210.1">
        <property type="nucleotide sequence ID" value="XM_025664187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VTX7"/>
    <dbReference type="GeneID" id="37167589"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="12"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="344" mass="36657" checksum="65E47A6AAA5E77D5" modified="2022-01-19" version="1">MSQTVLRLSARDSWDKLAQHQEAIPSAGKHEVLIKVRSVALNFRDIAISTGKYPFPVKDQVVPGSDAAGDIVEVGEGVSGLQQGDKVIVNFDLATTYGPLKSWHWGLGGPVDGVMREYFSVPAHAVVKIPESSKLSYAQWAGVVCTGVTAWNALYGNLPLRPGQSVLFLGTGGVSITGLVLAKAAGATTIITSSSDEKLQYVKEKYGVDHTINYKKTPDWAAEVQKVTNGQGADYIFENGGAGTIKQSLDAVAYGGNIAVIGFLAQAAQEEMPDVAALALGKGAVVRGIMTGSKQLLEEAARFIGNRDLPVPVEKTFKFSRDQVVEAYNYLASGQHVGKVCIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQX9</accession>
    <name>A0A8G1QQX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_175723</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510583.1">
        <property type="nucleotide sequence ID" value="XM_025654320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQX9"/>
    <dbReference type="GeneID" id="37157722"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034819187" evidence="3">
        <location>
            <begin position="18"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH52661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="334" mass="37092" checksum="D5B63216F3E67DF3" modified="2022-01-19" version="1">MMLSAFWVLAAIGLASTSETPASDAVTSLDPGLFSGGCTPEKMSIRKEWRNMTKVEQKSYLEGVNCLMDLPAQTGLEATTNRFSDLQALHRALTDTPVGDIIHSVGQFLPWHRYFLHVYETLLKEQCGYTGPMAWWNEAYDTDSGNLFRSEMWDADAFGGNGTEPDGCVTDGAFAYYTEHIGPQEQNTVFCMNRSWGNYEAILNTTGAAVAHCNTFDSYDEYFACIAATPHRGGHWAVGGVMADVKTSPGDPLFYLHHGYIDRLWYRWQMNDPAKHLWDMGGPAINESANVEPASGWPQTTLNYTLTTFDVMPDVTVADVMNPVGGYLCYNYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QR99</accession>
    <name>A0A8G1QR99_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C-4 methylsterol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_453515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510793.1">
        <property type="nucleotide sequence ID" value="XM_025661073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QR99"/>
    <dbReference type="GeneID" id="37164475"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="64"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH52871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="223" mass="26203" checksum="FB7FF405BBD17E19" modified="2022-01-19" version="1">MVLIGLQSKIPSLREQWDCARFVLLSHFTVELPQIWLFHPMAQFFGLSTSVPFPSLWTMAYQIAIFFVLEDTWHYFSHRALHWGPLYKAIHKIHHQYSAPFGMAAEYASPIEVMILGFGTVGCPILWCAVTGDLHIFTMYIWIVLRLFQAIDAHSGYEFPWSLHHFLPFWAGADHHDLHHEKFVGNYSSSFRWWDYLLDTEYSPEAIKRRRENKSVKDTKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRF2</accession>
    <name>A0A8G1QRF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_464151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510139.1">
        <property type="nucleotide sequence ID" value="XM_025661970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRF2"/>
    <dbReference type="GeneID" id="37165372"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="121" mass="13810" checksum="F83DF5E85258BF60" modified="2022-01-19" version="1">MPPTILPSLFKTLSFYLIPSPEWSPFWYNLYEGLGTCMIVWIQLYFFGMSTDITIQLIGFIAMHLVTLPIVAWHAYYGDGWTEEAVDTCLGIVPVLGLDVVTVWLVYWRGRAGDWELGAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRR5</accession>
    <name>A0A8G1QRR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Subtilisin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_382606</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511033.1">
        <property type="nucleotide sequence ID" value="XM_025656473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRR5"/>
    <dbReference type="GeneID" id="37159875"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00306">
        <property type="entry name" value="Peptidases_S8_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051048">
        <property type="entry name" value="Peptidase_S8/S53_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399:SF4">
        <property type="entry name" value="CELL WALL-ASSOCIATED PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399">
        <property type="entry name" value="SUBTILISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="DUF7580" evidence="10">
        <location>
            <begin position="176"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="598"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="541"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="541"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="605"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="643"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH53111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="880" mass="99808" checksum="40F0D2DF9CC87022" modified="2022-01-19" version="1">MASEDPIDFAQTAIAQVANIASLLGVESKRPLCGRLGAELFLVANYIDTAGLDQERQLRLRISKLLRDVEVMCNWPKNIPRNDYPLLEAIAKPFPDVASYKKAQKKIRRGLDQLTVCPRDAEVAISHIQRFVERNRKSSRRDESGDISSRKRAARPERSDLANELAHRVLREQMCCTCQSNGVRRQMERGHLVCLLLQPPSQSVASNNLVHFDMLFSSKPFWNQSHLTHWQDIELLVPNDHTHGKKCVRFFDGDDGYRDEKANNLSAKIRQRTDKGQFCRLLDLAKGWRLCLSIEDQELYHSFEPHKQKIDHIPGICLAKILSTYHLTARMKLVLAYIIAYSVWQYYDTDWMRTKWTSETIQFMRESDTSGGRGQGKLFTWKPYVSVHFNDEDPLCYEQYKVPGMVHVYPRIRALGIMLVEIGLGFPLPKREKQGQPLAAEVNAELLTAFNYAKDEERWKNFDYPDYMNSICHCLEPGTFDQAACMEGLSASEQRQNLKQRRNMLYEKVVFPLENLLQGTKWIDNYEKIAPLNVLSQDAKMKEANAPDNPDKGKAPERRRKRTESEKSASNWLLDLKEFNRELAQVAPAAGLRESSRRVRIAILDTGYDDNAPFFFSPDVMERLKGWKDWVDGSSQPEDCHGHGTHLVSLVLKCAPDADIYVARIAKSPHQLLNSSDKVAEAISWASGEWKADIISMSFGFADEQPCISDAIREALYKRKDSILFFAAASNYGANDREMFPARHESVISIRGTNSNGLFADFNPPKHEDEPVVFGTLGIDVPSAWPNSDGEEYRSGTSVATAIAAGIAGSLLGYISSRPPEKPFYNAKNRAWTRRGMNAIFRAISSNTLQSRYLYLTVRGLIGIPEDARWAKIGGKLSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRW3</accession>
    <name>A0A8G1QRW3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_453815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510630.1">
        <property type="nucleotide sequence ID" value="XM_025661138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRW3"/>
    <dbReference type="GeneID" id="37164540"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034053223" evidence="1">
        <location>
            <begin position="20"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="164" mass="17767" checksum="E29BCF21190D767E" modified="2022-01-19" version="1">MKLFSLTTTLTSLIATVSASLPSTYTLVADGGWTVVTDGTHLYIGTGDIKHYPILILKGGSNNTMITGHKQYDTTTGIQHLYVKKDETAPIALTEPNGAAPARASVTGFDVDEGNYLLLDGVEAWDVEPNEGQIRRIYWLGGEEDNVGDEYKGIGLWVKECRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSC8</accession>
    <name>A0A8G1QSC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_481697</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510619.1">
        <property type="nucleotide sequence ID" value="XM_025663070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSC8"/>
    <dbReference type="GeneID" id="37166472"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF6">
        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH52697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="725" mass="80899" checksum="37446363148C86BC" modified="2022-01-19" version="1">MNSPPPGRPGRQRRPRVPDALRKRAARACLPCRQHKEKCHGGGPPCARCQQYNRTCHFEDTRPKPTGMSAVPSQREFQMERIIRHFLGEDISLDPARLEETADLLESGRYRGTPPETRGVENEDQAPESYSLEPLSTNTMHYSGELSHWNFSKMIRRRLQSLGTPKGQKDGLNPSDGFFRATGLQSASSCVASAIEYLPPRPVAEFLTNTFLEYAQTNYFYFPESVFREKMDYYYSVDRPLVIDDAGWICTLLMTFAIGTQFAYMQTSSTEKPPFSEDIPDDRIGMDLYRFSCRLIPDLITTASLETVQAFLLLGVYTLPIDTAGLAYTYYGLAIKMAIQNGMHRKHIAPSVSPVIVEWRNRLWWTAYSLESRISILHGRPVSVSPSETDADMPADLVELRQPSGISNLPNVTAAIHLTKKLGKVAQIILRLRRCPRSHQDAYLHQLCNLRMDLSRWWDSLPKTLHCRDLDPAGPLFRSNVHLELNYATALIYMGRPFIFLQNEIADSGGYGSQKEGGRAELIETFSRNCTRAAIRIIDLCQLLHDSVGLARVSYTEFSSCRTALLALIAQLLSGSSEPIGGALTRGMGLIRQICVGLESARSEIAVIEALERARQQLGLGERSSLGNSSETGYDQFQKWAKLWRLGPLNSEAFSPPAGVDSPNNPGSIPSFDGFFSSFPQELDAFAAIPGSEDTAAPPSIWPVPDAFLSFPGNVDAELEFDRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSI2</accession>
    <name>A0A8G1QSI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DUF1212 domain membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_454329</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510048.1">
        <property type="nucleotide sequence ID" value="XM_025661261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSI2"/>
    <dbReference type="GeneID" id="37164663"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF10">
        <property type="entry name" value="DUF1212 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_3G01440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="640"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="764"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="815"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="411"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="688"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="46"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="275"/>
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        </location>
    </feature>
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        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH52126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="850" mass="93196" checksum="04671FA65E2786A4" modified="2022-01-19" version="1">MSESPRHDDASYELLGRQNSWEGNDETLVPRNSGEPSAPSHPEGEPPAAATTEEGGPNETTRPARVRFRSVSNNNETVPERPPMPRGDSEYSLRSVHSFVPTTAQSTDLADYFERDYAQEHDPVEREGNEAEKRSSPTANESRDTSLDKDESQQPVSAKDRWRNASKLLRQKTVLLGERLGRPLDDVGDLGAAMLPDDLEGGYPPRRRGDEKEPLDPHGRNDEPPPPPSAEAHRLVRSMTQHNMHQRRKPKSAYAKSGQETPDGPGRPDSWYGAGTPGGRGGGGILSQLLKLHAQQQANRDNMSMTDSSDNESVASSGTATPRRDFSAGTFSSGTATPKKEKVKWYKKSSHQSTASLVEASMNLSRASLPASADTLVNIPNKKKGKKKRKTRLEDEIRVTVHIAEILARQRYIMQLCRALMRYGAPTHRLEEYMQMTARVLEVEGQFLYLPGCMIMSFDDPATRTAEVKLVRVVQGVDLGRLAETHNVYKNVVHDMIGVEEAIQELDLIMKRPPRFNKWILVVTYGLASVAVGPFAFDARPIDMPIIFFLGCLVGFMQHVLAPRSVLYSNVFEVTAAILTSFLARAFGSIYATVDGTHERLFCFSALAQSSIALILPGFMVLCSSLELQSHQMIAGSIRMVYSIIYSMFLGYGITVGTTIYGLIDGNAASSTTCKNEDVWGSKYIQHFIFVPIYVIFLAIINQGKWKQVPVMIVIAVCGYVTNYFSTLKLGSNSEVANTVGAFTIGLLGNLYSRLWHGHAATAILPGIFVLVPSGLASSGSLLAGIQYADEVRDNLRSGNTTATDSTTDSSIASLGFGMIQVAIGITVGLFVSALIVYPFGKRRSGLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QST0</accession>
    <name>A0A8G1QST0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Stress response protein NST1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_159886</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">May act as a negative regulator of salt tolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511125.1">
        <property type="nucleotide sequence ID" value="XM_025654223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QST0"/>
    <dbReference type="GeneID" id="37157625"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051195">
        <property type="entry name" value="Fungal_stress_NST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025279">
        <property type="entry name" value="NST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780:SF10">
        <property type="entry name" value="LD36051P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13945">
        <property type="entry name" value="NST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="281"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
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        </location>
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        <location>
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        </location>
    </feature>
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            <begin position="895"/>
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        </location>
    </feature>
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        <location>
            <begin position="1146"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="54"/>
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        </location>
    </feature>
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        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <begin position="130"/>
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        </location>
    </feature>
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        <location>
            <begin position="144"/>
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        </location>
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            <begin position="159"/>
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        </location>
    </feature>
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        <location>
            <begin position="307"/>
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        </location>
    </feature>
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        <location>
            <begin position="327"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
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        <location>
            <begin position="525"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="553"/>
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        </location>
    </feature>
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        <location>
            <begin position="736"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="765"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="922"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU049441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH53203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1197" mass="132621" checksum="B5121BB667BFA089" modified="2022-01-19" version="1">MAPPQTPRPNPGSTMSDPASTSIPAHATNGEAHAPNDHHHDQLPLSDSKPVSVNRKKQKRRQKQAARLAAERQFGNGHISADMSEQNGLSPTAPASHVSDEHDLDERANGETYYEEIHDATHDLDDHPPSLSNGQPGQQNATARKSKKKKGKKNRAGSQTMGDESSTPLSTPSVSMSQHLPPPLPPHLPHTLLKTGKDRSIWNTSTQEERENIKTFWLELGEEERRQLVKVEKDAVLKKMKEQQKHSCSCTVCGRKRTAIEEELEVLYDAYYEELEQYANNNQGSFEKGPPMVPPPRLYHPPLRSPGQHTRTQGQFHPSRGRIHELPEDDEDLEEDYDEDDEDDEPYSDDDYEDEETRAARADFFAFGNSLTVKDGILTVADDLLKNDGKHFIDMMEQLAERRMQREEDTQYGIAAAHQSLHGGHNHGPLDDDDYDEEEDEDYDSQEDEDYEEDEMVSSGNWPGGDAVQADSFLQDAMTEEQRMEEGRRMFQIFAARMFEQRVLTAYREKVAEQRQQKLIEELMEEQTRNEQRNAKKAREAQKRKDKKKLQKQAKEEEKARREAEKAAEEAAAKAEQEKKMEEQRRKREEQKKKREAERKAQEAERLRKEAEKQKRLREERERQAEIERKQREQKELEKKRREEARQNDLREKKTKDERERQVKDAQTRREAAPKTENEGQEKRDPQAKRVSHTGPVPIPASLQHAQALPAYLQSPHYQIATPIVPKAPTPARPRQPSQQGSHTSSPRSQPASTEPSQVSISPRSMAPSQSSGASSVTSKQGHGQPPLLHHPQPSTPLSPLGALNRSHPPGFSPSNPPGLGLVSRPPIGHELPSYPPHSGPLMNQLRGFPAPNGLPVLPSMNGTRPMPPGRGFPLDPGHGLAFHQQPITNAFAAQPSGLSHAHSRQPSSSFERSPLDAHAFPISRPSPIKRPSSTQQDQNNRSAQRDVDDLSAHLGSSALLDDSDVPFTSNLSQSLPGATAPGTFPGPTRASFAGTSLFADPLAAKHSGFPIGPSVGNTWSTQIPFGTSPFPSAPTWGTGPGSGWSNNAFAPGGHHRAHASRPVTIRLLVIQACKQLNMMSPSKGASGYHDVNVVLRQVNQLRPANEPPISLKEMLDICDTEGNTQNGGGSFSIRSDETGECVKFEPDTNSASSGHRGSIVPGEIGSPVPSSSLPAFGGIGSSTPSVLRQFSSPTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT57</accession>
    <name>A0A8G1QT57_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor TFIIIC complex subunit Tfc6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_429858</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511121.1">
        <property type="nucleotide sequence ID" value="XM_025658268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT57"/>
    <dbReference type="GeneID" id="37161670"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="754" mass="83896" checksum="131E3B9D246A10D8" modified="2022-01-19" version="1">MPRPRRSNRASGARTKYVHDPFEAAGLSDEGEGPSTSETPQRKKSKGKAKQAVADEGSSDEDFAMDDANGADDDDDDDDEYNDNDVGMVLENEDEDAEEDDDASASEVDGGSRRQRKKPAAAATPKPSSSVKKRRPDGSLAVPGEETHSRGSWNPLEHVGKAVHLRVTFGTDERDILSIISARDRWYKGVDSTFPTRETLNESHDLPDYGYGNSFGLEAEDMKRESSRAWDWYYSRDVGAPFRKRQRIQKLKENDARLVYFPRSRGPHTVLAGPVNDQKVFSLAQHDVLDFGEAWDDDASTAQKQGKQAKTKQSERKKKKREGWLLNLGNKAQCLAWVPNQTGLTQYLSVVAPILPDQKEQYPDPYKDQAAPAFRPSAPYPSALQLWEFKAEEAASLTKTTDMTSKPRLRLALCTDWGDLRRMAWCPMPRDPRNEDDKDAQVNVGLLAGIWGDGRVRVIDVKLSRNPDQTEYYKLQTPVFEAKPHSTVCTSVTWLSPSDIAVGCANGFVAIWRIVSSPSSPSNPIPYFYQQLHSTWILNLASAYPTHPYLISTTSMDGESRLTSIIDPQKDSVSANRMRVGTAHLTYSPLLHSFVSGDENDFLRLLAIRRFFTSTAVARLPSMVSALGPCSFWHPSLLVGCTGGTVQATNPLRRMMHAKEKQWQQTWFQHEWARGSGTGTGTSRFHDGYRAEHTSLLRNLVGDPRLINGTAVITIFDEETHVTALSWNPNRVCAGWAAAGMGCGLVRVEDLALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTS6</accession>
    <name>A0A8G1QTS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_491837</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511635.1">
        <property type="nucleotide sequence ID" value="XM_025663740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTS6"/>
    <dbReference type="GeneID" id="37167142"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="9">
        <location>
            <begin position="133"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="342"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH53713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="442" mass="48980" checksum="99220755157EBFE8" modified="2022-01-19" version="1">MSKVLNFFVGGRQRKDQDSSSRVDPPNLSQSSAQASFPLEFPDGVEVLHDCPNATVDICFIHGLSGDRTTTWTAQNQSDPWPKTLLPSELTTARILTYGYDAYVVRRSVAGSNRLVDHAINLLNDLTMDRDDHNAASRPIIFVAHSLGGLVCKKAILSSRNNPDIHLQNVFKYTAGVIFMGTPHQGSWMAKWATIPATALGLVKSTNKLLLDILQTDNQFLQSIQNDFLSMIRELQGNGRSLRVTCFFEELSLSGYGQVVSRNSATFDGFKAISIHADHCNMVRFSSAKNTGFTRLAGELKRWEKEVRPLPEPADRLASCLSTCERQAKRGCDSLDETISKRRRTASRNSLQERDYSDNTDYDGSSIFDGIDSTEDTAVQPSQESCNGDNSESEDLEEDTSDEPSRSSDDTEAHNESLTDDLAPFSQNTAHSEEDSGDETDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QU02</accession>
    <name>A0A8G1QU02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-1,3-glucanase/mutanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_383690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510466.1">
        <property type="nucleotide sequence ID" value="XM_025656525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QU02"/>
    <dbReference type="GeneID" id="37159927"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034217667" evidence="1">
        <location>
            <begin position="21"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="504" mass="54675" checksum="233959728395AFEF" modified="2022-01-19" version="1">MKFFKLPVLALAGLFTAASCAPTGQNTTDPVNGTTEASTDRLVFCHFMIGITSNRQSAADYDDDMKRAKSLGIDAFALNIGVDPYTDTQLNFAYESAARNDMKVFISFDFNWYNIGQASTVGQKIRQYGSLPAQLKVDDKVFASSFAGDGLDINQMQSAAGTEVFFAPNFHPGQGNFGNIQGALNWMAWDNNGDNKAPSAGRNVTVADGDKAYVNALNGKPYIAPASGWFFTHFGGEVPYSKNWAFPSDLLWYNRWFEILNLAPRFVEIVTWNDYGESHYIAPLASPHTDDGASKWVMDMPHDGWLQMSKPFIAAYKNGEKSPDKYITEEKLIYWYRPTPRNINCDSTDTTMDGSPNNSSGNFFRGRPNGWESLQDSVFVVSLLKSPGTIQVASGQNSQKFDAPAGASAFTVPMGVGQQKFALVRDGKTVLSDTSLKDIVNTCICGIYNFNAYVGTVPAPPTIDKLGPAGLSALQQGLRVACPTNTLGLGSVASATPNPTPSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QU06</accession>
    <name>A0A8G1QU06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDCD2_C domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_471484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512218.1">
        <property type="nucleotide sequence ID" value="XM_025662476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QU06"/>
    <dbReference type="GeneID" id="37165878"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="302"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH54296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="442" mass="48154" checksum="783E03BE999B0B0F" modified="2022-01-19" version="1">MDPYDSDSSFDDEGDFSETNVLLGYAADEIVEDTISHLGGWPTWLDDATPPPGDFAKCKVCNQPMLLLLELHGDLPNDFPDDERRLYIFSCPRKACNRKPGSIRALRAVRKLKIEPQHQPLRQKEEQKPEPSNKEKEEEEKKPAAPKPDLGASLFGSSTLTGSVSASANPFSAGASSTSTNNNPFAAPAPSPGLAAKPTPSPAPTLSESFADKVRISSQQQQQPKTNLIPPPEASTTPNTPWPAQSDFPTPYTNFYLDAEYETMSRPSTPTIPANVTIDNTEEEGPNGGAAELKDTFESELDKAFIRFSTRLGHNPEQVLRYEFRGTPLLYSHADAVGKRLHDPSKTANPNAKVTTVGGGSRMPRCEYCGSERVFELQLVPHVISVLEDGREGVGLGPKDDAGMEWGTIILGVCGKDCGPKEVGVVGYREEWAGVQWEEQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUN2</accession>
    <name>A0A8G1QUN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_441116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512593.1">
        <property type="nucleotide sequence ID" value="XM_025658798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUN2"/>
    <dbReference type="GeneID" id="37162200"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="117" mass="13099" checksum="C8D2F873F8FCAA17" modified="2022-01-19" version="1">MVLTLTYEFSCDENPLRARDETETAAMVKTEAIPPSSLGRSGGAPDPSMVRAHKQADISGSEAAESEADDFLNRYRTLSVDFIMQLQSTEYVPQDSEAKVTSDDLRSFRFLRDLFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV64</accession>
    <name>A0A8G1QV64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA photolyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_523001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512074.1">
        <property type="nucleotide sequence ID" value="XM_025665308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV64"/>
    <dbReference type="GeneID" id="37168710"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF9">
        <property type="entry name" value="CRYPTOCHROME CIRCADIAN CLOCK 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="7">
        <location>
            <begin position="8"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="602"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="611"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="291"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="336"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH54152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="642" mass="73787" checksum="78A895F563F7B689" modified="2022-01-19" version="1">MPQHSSPPTVIFWHRTDLRLHDNPALQAALSLNPSTFIPIFTWDPHYAYQARVGPNRWRFLLECQNDLSQSYRKLNPKQKLWVIREAPQTVFPKLFKAWGATHLVFESDTDGYARERDETVIKLAKEAGVEVIVKPGRTLFDSDEVVKHNKGEPTMSIHQVEKAVEQINNGVPDRPVDAPESVPDPVGEEKMRAISGIEHEVPDQEDDLNAAYRTKYNDTQYRSIAGPNGDFSIPTLEELSIDPSQATTPHHGGETIALEMLRTYLQQNEDFVATFEKPKTSPAAFHPQATTLLSPHLHFGSLSVRKFWHDVQDTLHERESAHKPTSNLPTNLPGQLLFREMFFAAQAALGPVYAQARGNKIARFIPWHLQSNHDEETGLVDRTYTIDDEQAEVWFRRWKEGRTGFPWIDALMRQLKYEGWIHHLGRHSVACFLTRGGCYVHWERGAEVFEEWLVDHETASNVGNWMWLSCTAFFTQFYRCYSPVAFGKKWDPEGLFVRHYVPELEHYDKKYIYEPWKAPVEDQKRWECRVTGDGMVEKDEETGLRTYPEPMFDFDERRQTCIAQMKEAYGVHLMGDDERVMDGSWKEVFGYEIKDGRVVEETNEMADGDGGDHEGGQKRGREVGDEGGENADGGHTLKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVU7</accession>
    <name>A0A8G1QVU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Decarboxylase Dec1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_499743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512531.1">
        <property type="nucleotide sequence ID" value="XM_025664079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVU7"/>
    <dbReference type="GeneID" id="37167481"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="250" mass="28178" checksum="A82F26A6E69D0C54" modified="2022-01-19" version="1">MPFGTFELTGDAIPQYAPPYPTGDCDFTGSTILVVTYRTTAHSVAPFVPSMLELEDEPLITVRLLRHSMTSFGPYNEYTHGVDVRYRGEKYEYFLSLILDNESPVLAGREQYGFPKKFGTVEFNPSEPCGTRVMRGHVEHPPHQKILQMNYSPVRKQAVPDVGMTVETRCMNLRVLPSPIAGQPPSVRELMPLALKITAKEIWEGEGSVSFPEPSEVDPMHRIEIMRYESAHFLREANLWLGPTGDVYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QW79</accession>
    <name>A0A8G1QW79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Microtubule binding protein HOOK3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_73739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513463.1">
        <property type="nucleotide sequence ID" value="XM_025665628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QW79"/>
    <dbReference type="GeneID" id="37169030"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HOOK N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="189"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="515"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="593"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH55541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="757" mass="86905" checksum="E8E2C396B721D58C" modified="2022-01-19" version="1">MAAEHTVTQALLEWVNSFALGKTIRTTEELSDGTIIWEILQDIDPQYFLDEIPQRAPSDHWLSKWQNLKHIHKLLVNYIRQQPDGMPTGLDPNPNLELVAEKNSVKEANKLLKLLLIAAIRSPNAQTYVETLQSLSTPTQETLKNIFEEAQNGQHEAIDGEDDVKEERDLPVDPELQFEERVGKVLAENNRMAREKKDMQKQIDDLHDRLARLQENNDTLQSRLASTEDRLVNLRSGKGDLGLSAKALESKSRQQEDIIATQEARLATAQDEIDSLRMTVESLRVKNQRFQKLQDDYDELKTERDQLARKANAAEKYRQKLQASQDFEKENQSLRNQIKDFQQQLKEADSQQKWNSEREVELEEYRRVLPRIEQECSEIQNLKKQLEFNNHALTERLSNADEQRERDDALISELRERIRELEGSPGSPSLMPGTETPKLEGTLQKDFEAIGVKESQLKSENEELKKEVESLKGPSVGLDFSDAFNETLQQARANSSQSDDYWKLYDQYTSALKRLAEAQEALDVSKRSLNDALAEIELSNKENMDLIAEIKASSASDLTKAREGEDDAMRRLYNLQAELDSTQALVQVTCAERDDLRNLLEKKQAEFRAEDHEAAEEMKKLLAELTAQENGDDPEAAQKSAVELIRQVAAQIEKNLERLAKRAEYIHQQNEHIKFLQERIKQLEEDTDDGISKERELELQKIIDAQARELTLMSSSWYELQNRLQNNNIGLARYRNGSLADAQKGWLARQRSVVAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWV3</accession>
    <name>A0A8G1QWV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_472435</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510762.1">
        <property type="nucleotide sequence ID" value="XM_025662551.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37165953"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1620:FF:000003">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="743"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="397"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="492"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="562"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="650"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="896"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1192"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH52840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1416" mass="158716" checksum="43C8E7036B7C83EF" modified="2022-01-19" version="1">MSSIARSRPTRRSAAARRSYAIEETSEEEDPGNVTPTASQHDEDDDDSGEATPVPKKPRIEKRSSRRRATVEQTTPKATRTTRRSRRSATAELSEASQLTDTNDNEGDSVASVEEPETASQVTASVKKITKPSVSPPPSQPRSQRGSVPPLADITESAVNQTPAKSESEEKPQIAMINPNTTVLEKPMDIMMKSRLLGPSAPEEPSEPKSRLIITTLILMNFKSYAGKQIVGPFHASFSSVVGPNGSGKSNVIDALLFVFGFRASKMRQGKVSALIHNSANFPNLPYCEVEVHFQEVLDLPTGGHEVVPDSQLIISRKAFRNNSSKYYMNGKETNFTAVTTLLRDRGIDLDHKRFLILQGEVESIAQMKAKAANEHEDGLLEYLEDIIGTSKYKTPIDEAAAELETLNDVCMEKNNRVQHVEKEKNALEEKKDKALAFIRDENELAQKQSALYQIYINECGDNIRVTEEAILQMQELLNLELEKHEGNESGIKELEKAYKRGMREYESMEKEMQALAKEMAKYDKESVKFEEKKKFLVGKQKKLEKAMQSTRLAASECESLVQKHADDIERKSKETTQLEKEMKVEEEELNSIRESLKGKTQGLSDQITAKQKSLEPWDEKINKKLSAVAVAQSQLDIIRERSNAGAVLLEEAQAKVASIEEGLATKETELEERKEQKSTLEQEVEKLKHDLKKYAHREPEVRAHVSSARQKADEARASLASTQNRGSVLSGLMRLKESGRIEGFHGRLGNLGTIDEKYDVAISTACPALDNMVVDTVEVGQQCIDYLRKNNLGRANFILLDRLPRRDLSSIATPEKVPRLFDLVKPKDSKFAPAFYSVMQNTLVAKDLEQANRIAYGARRWRVVTLDGQLIDMSGTMSGGGTRVARGGMSSKQVAETSREQVAQLEGDLEEMERKFQRFLEKQRQMEAAIRERSEEIPRAETKIQKIMIEIESANRSLADAQRRVKELSAEHKPSKTDANQAAALEKQIAALEEEIEDLREQKGGIEEEIQTLQNKIMEVGGVRLRGQKAKVDGLKEQISLLAEEISNAEVGKSKNEKAIVKHQNSRADAEKELEHVTEELEKLNADVANQANDASGWKQKVEEAEEALDEKKEDLGKVKAELDEKVAELNESRATEIEMRNKLEENQKALAENEKRGRYWQEKLSKLSLQNVSDLGEEQEATELQMFTQDELMEMNKESLKAAIAALEEKSQNASVDLSVIEEYRRRTAEHEARSADLTTALASRDSAKARLDGLRSARLNGFMEGFGIISLRLKEMYQMITMGGNAELELVDSLDPFSEGILFSVMPPKKSWKNIGNLSGGEKTLSSLALVFALHHYKPTPLYVMDEIDAALDFRNVSIVASYIKERTKNAQFIVISLRNNMFELASRLVGVYKVNHMTKSVTIENKDYITGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX47</accession>
    <name>A0A8G1QX47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_460564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513943.1">
        <property type="nucleotide sequence ID" value="XM_025661725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX47"/>
    <dbReference type="GeneID" id="37165127"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22189">
        <property type="entry name" value="PGAP4-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029675">
        <property type="entry name" value="PGAP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410:SF1">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="437" mass="50600" checksum="E64B988D9D4EFD61" modified="2022-01-19" version="1">MLPFSLNKVAKQVLTHIPYYLQLRASKIFILSLFVWLLIFYYCRISLWRDPHSAFFQDRHVYELDYSLHREREAWHFISQHNSGIDPPDYVKSGGTPTACIAMVTVRRDSDHYFEASVGSLLEGLDERERQALYLSILFADTDPRVHPSWDQKWVGRLVDAADTYNVSEGQLQNLQDLERDKNFYEKGVFDYIYALRTCQEVNAPYTIIFEDDIILATGWFSKTLKALSDISQRNQQPRNPWIYLRLFYTETSLGWSDSDMAYSNMPLIFGLLMLSTFSSLMMLRRTRFERLHVDTLSIVVISMVCVPAFTALVYMAGKYNLMPLQGVVEMNKFGCCTQGLVFPRESVNGLIDFLTARGHGQTDSMIEEYADQSQLTRYALAPPQLQHVGLKSSRNNLDINTQSTWAFWFETNDAAKLRKEHAALLEDDEVKRMLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXZ0</accession>
    <name>A0A8G1QXZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_141372</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512132.1">
        <property type="nucleotide sequence ID" value="XM_025654076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXZ0"/>
    <dbReference type="GeneID" id="37157478"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH54210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="259" mass="28088" checksum="B6F75BA92A9CC60D" modified="2022-01-19" version="1">MSTLSSPRPSIASSRAHSPTPTSSHRPSLDTLNTNYNLNNLSASSTPSTARAVSPSLHPRRNRAALRDYYNLKPSSAADPNNDGRRSRSIPRHTDAGDISSSSSGAGGPSILSTTGTELDSPDFDPQRYVNQLLASSSLSTVLKAENTLVGDIRTLDSERKALVYDNYSKLIRAVETIGKMRRTMDDRGAPLTMTKTLGPAIAFVAETAGGLIQEGEEQQRRMKEVRESEGVERRRAEKGTGVKEVREACEKVMEGREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY41</accession>
    <name>A0A8G1QY41_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional cytochrome P450/NADPH--P450 reductase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Cytochrome P450</fullName>
                <ecNumber evidence="16">1.14.14.1</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">NADPH--cytochrome P450 reductase</fullName>
                <ecNumber evidence="16">1.6.2.4</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO85DRAFT_380021</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <cofactor evidence="16">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="16"/>
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        <property type="term" value="F:heme binding"/>
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        <property type="term" value="F:iron ion binding"/>
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        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
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        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
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    <keyword evidence="7 16 17" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="509"/>
            <end position="649"/>
        </location>
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        <location>
            <begin position="688"/>
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            <begin position="476"/>
            <end position="500"/>
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        <location>
            <begin position="491"/>
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        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="17">
        <location>
            <position position="414"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
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    <sequence length="1104" mass="122678" checksum="62C9BB1CE4D214F8" modified="2022-01-19" version="1">MSSVKHVPIPGPKGVPFLGNVYDIDQEMPIRSFELLADQYGPIYRLTTFGVSRVVISTQELVDEACNEERFAKSVDGGLGQLRHLLHDGLFTARYPGEENWALAHRVLLPAFGPLSIRAMFDEMQDIANQLVMKWARQGPETPIVVTEDFTRLTLDSIALCAMGTRFNSFYHDSMHPFVEAMVGGLQVASYRAQRPSLLNQLPTSDNNSFWNDISYMRNLAKELTEDRRKHPSDKKDLLNALILGRDPQSGKGLSDESIIDNMITFLIAGHETTSGMLSFVFYYLLKNAPAYKKAQEEVDTVIGRRKITVDDLPKLPYINAVMREALRLNPPASAIRVHAHPTKNKEDPVTLGNGKYVLNKDEPITVLLPKLHRDPKVYGADAEDFKPERMLDENFNNLPRNAWKPFGNGMRGCIGRPFAWQEGLLAIALLLQNFNFQLDDPSYDLRIKQTLTIKPQDFKMRATLRHGLDPITLESALNSGSVPPESSKVASRERKKDAALPEGDMKPMHIFFGSNTGTCEALARRLADDAAAWGFSARVNSLDSATENVPKGDPVVFIAASYEGQPADNAAHFFEWLSGAKDNELEGINYAVFGCGHHDWTATFYRIPKAINELVGEHGGNRLCDIGLVDTAIADMFTDFDNWSESALWPAISAKFGSKAQGQAGKKASSGLQVEFSSEKRVTTLGLQLQEGYVIENQLLTAPDVSAKRLVRIKLPSDMTYQCGDYLAVLPVNPTSIVRRAMRRFKLPWDAFLTVRKPSQTQSGPSAIPIDTPISAFALLSSYVELSQPASKRDLIALADAAMADEESQAELRYMANSPSRFNEEVVTKRLSLLDILDRYPSIGLPLGDFLAMLPPMRVRQYSISSSPLQDPTECSITVSVLNAPSLSGTDEPYMGVASTYLSILQPDERVHIAVRPSHSGFKPPSDLNTPMIMACAGSGLGPFRGFVMDRAEKILSRSDSITEKPAPAILYVGCRTKGKDDIHAEELAEWSRKGIVDVRWAYSRPTDGSVAQHIQDRITNDRDEVVSLFEQGARIYVCGSAELGKAVRQAFNNIYVDVMKERRRVALEAKQEDVPPEVNDEEVEKFFDHLKASMRYATDVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY87</accession>
    <name>A0A8G1QY87_9EURO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_451546</name>
    </gene>
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        <name type="scientific">Aspergillus piperis CBS 112811</name>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
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        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="RAH55201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025660613.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
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        </location>
    </feature>
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        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RAH55201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="411" mass="45468" checksum="860EEC274BD074E1" modified="2022-01-19" version="1">MVSPAQSLRDQWKEPSDIFTVLLIIGGDIVQQALGAVSGGFLTPVAFSYGWVAYAVSALLSATGDGRLMPETPITNLRVINLKSGYCRWNRSWVLGRVFQDYEHWMPSAVRERLEEHPSQNSDEEKKVPGSLPGGRQPEVALCVAVYHWSTEGNSLARPGHDWVWWTGLLVSLIQIAISAVPFGIYGDWRVFLVTVSGTVLAYAAGALPGWRKEKWACRRGSGKDVALTLGNGTTHVVIVHGGHPDGLDLEDLAGAEVRHSGAATSNRRSISRMIESCNTTRLFIAFLAILWLVLLITSQAIESHTWYLVGVGGLGMIQNLIVAGAPRFPEMLGISIELSESSQGTPSVFAEYKVMYTLMELELGYKGFGRALLAEFFPGKLRDWEENWWALTNNEERRVILDEKKRGLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ47</accession>
    <name>A0A8G1QZ47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Alpha-1,2-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_479155</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EME1/MMS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514159.1">
        <property type="nucleotide sequence ID" value="XM_025662935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ47"/>
    <dbReference type="GeneID" id="37166337"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20085">
        <property type="entry name" value="XPF_nuclease_Mms4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.670:FF:000004">
        <property type="entry name" value="Crossover junction endonuclease EME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047521">
        <property type="entry name" value="XPF_nuclease_EME1_ascomycetes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21292">
        <property type="entry name" value="EME1-MUS81_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ERCC4" evidence="15">
        <location>
            <begin position="311"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="202"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="249"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH56237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="629" mass="70847" checksum="B5DF1EB233B0BC48" modified="2022-01-19" version="1">MPEVIDLLSSTPPPPIERREQLSIRRAHSHPPVVPASDSIFSDEIDLSAFTYDNPIEQPAKRRRLSHEITPAKEVPLPPAKNSLFLFSDDDIILSSDGPAPAKPPAWNGESDPIVFTSSAPETRHNLPVRPAISSRDINPIPIDDEDDSIPNGTRNNRLRREEIQVSSDQLDFPDVDDLLDVAQRVEANAFSSRTANLLATLEDRSRGSNDDSVSRSTRGRKQQDQSDDIDVEEMPPPRRPQRKTTKVSNEEKEAKAREREAAKAQRERDKQLEKERKQKAKEDKAREKQLAADIAEVNKLKVDKKDSTHEMLIDLASTFTDTSLGNQTSELMCLLKVDLTFFPSAIPNIVKWRRKVRATYNDSLGHWEPCALHIREEEEHVLCLIAAQDFIDMIVPPPTSEPRNTVSDHVQRLKSAYPKSRPIYLIEGLTSLMRKNNNAQNRAYQAAVRRQFEDTSARPSGRRKQQQPETITPIDSDTVEDALLDLQVTHSCLIHHTSSPAESAEWIKNFTEYISTVPYRRERMDLNDSAFCMDVGQVKPGENRSDAFVKMIQEVNRVTASMAYGIATQYPSAMDLVNAMRKHGPGLLEDVKKSANKNGALTDSRIGPAVSRRLYKVFMGMDPTSTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZH8</accession>
    <name>A0A8G1QZH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cornichon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_401375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513376.1">
        <property type="nucleotide sequence ID" value="XM_025657154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZH8"/>
    <dbReference type="GeneID" id="37160556"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033466">
        <property type="entry name" value="Cornichon_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01340">
        <property type="entry name" value="CORNICHON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH55454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="138" mass="16160" checksum="3225008A5A5406D3" modified="2022-01-19" version="1">MSGEAWLYLLAVLINAVNLFLQVFFTIMYSDLECDYINPIDLCNRLNAYIVPEAAVHAFLTFLFIINGYWVAIVLNLPLLAFNAKKIYENQHLLDATEIFRKLNVHKKESFIKLGFHLLMFFFYLYSMIVALIRDESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZN3</accession>
    <name>A0A8G1QZN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADPH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_514060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515278.1">
        <property type="nucleotide sequence ID" value="XM_025664736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZN3"/>
    <dbReference type="GeneID" id="37168138"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="68"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH57356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="448" mass="48964" checksum="91D0E3CF1E961CF7" modified="2022-01-19" version="1">MPSRYLNADESEIVEIANEPASGVNCNFQCIRRLIADDPLQIPYFTPKQTPTAGTALVPAPQDPTTPKLFTPLSIRGIVLQNRILLSPLCQYSAEDGHHTDWHFAHLGGIISRGPGLCFVEATAVTANGRITPEDSGLWKDSQIGPLKRIVDFAHSQGQLIGIQLSHAGRKASTVAPWLSMNRGPGAPIKSVNGIDHDGFAPRHGWPDNVVAPSAIAFKDKNIIPRELSYDEIQSLVVAWGEAVKRAVRAGFDAIEIHGAHGYLIHEFLSPVSNKRTDEYGGSFENRIRLALELVDISRQHMTPSMPLFFRVSGTEWLEHLENEPSWDASQTVRLAEALVEHGVDVLDVSSGGNDPRQQIKGGPAYQSPYAFQVKEALGDPLLVASVGATTSGPQANDLLNAGLDMVIIGRMFQKNPGLVWTFAEELDVDVKAAHQIHWGFAGKRRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZZ6</accession>
    <name>A0A8G1QZZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_42332</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514766.1">
        <property type="nucleotide sequence ID" value="XM_025658009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZZ6"/>
    <dbReference type="GeneID" id="37161411"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002123">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF22">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="433"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH56844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="877" mass="98346" checksum="C64F195034D33E4B" modified="2022-01-19" version="1">MEDDRGTPGKVRKKSTPAHRKSLSCEYCSRSFARLEHLQRHLRTHTKEKPFSCDICSKSFARSDLLVRHERLVHPTETAANREHRAQNSHDVPQTQPPIIQPTHHESRMLELADAVPIHTQPVPPPPPEVQVQPPPIVETPHFNPSWGYDLNLLSHAASHVALEGEQESLESLRKSSQNVGTSQPLPHVPERAITDNYGVEPSILDLADLGDPVQDFTVFLESVGLSSDWDSGVFSTVEDPILPTTLPMDSKPAIRDMGRLGPELMSDPRTAADEQPSFSNFGSRLPSLQPEPHDVDDRLGFGDEGPRPAWDISNADRQVFLSKLDEFAYILPKNFIPPSRHALSRFFAGYINGLNEHLPFIHVPTLSVAKCSPELTLALAAAGSHYRFENNRGIELFHAAKAILLQRLHRRDSKQVACPTWNFLSPASGFHNSRGSSATSNHTSSPFQQQHPTLYPADPSGYAPEDSDAHMEVIRTFLLLTVFASWERHPELLREMLSLQSTLARLVREHGLVEPPPSPDPNNWEDWIRREGNRRTKFIVYCFFNLHSIMYNIPPLILNAELKLNMPCSHDVWKASNAAQWRRVLRTRHGPEVSFQEAFARLFFKSSTSSASAPISPLGNYILIHAIIQQIFFARQLCLSAPSMHGTSLRQEDLSALDNSLSAWKALWKRTPESSIDPQNPAGPIAFTSTALLGLAYIRLHVDLGPCRRLITQDPLQIARALGESPPVARSPRLIMALLHSAHALSIPVRLGIDFVARTHSFFWSIQHSLCSLECAFLLSRWLLSIPITQAEQRLSEHERKLLLWIKSMMDETDMAVDPPGAPDLDFIANPYKAKQLSVAIVRVWARTFKGNTSWAIVDLVGSSLDTYADFLETQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0E7</accession>
    <name>A0A8G1R0E7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_450274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514804.1">
        <property type="nucleotide sequence ID" value="XM_025660338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0E7"/>
    <dbReference type="GeneID" id="37163740"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_eL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH56882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="51" mass="6253" checksum="5C1B92F010C7A5D6" modified="2022-01-19" version="1">MPSHKSFRTKQKLAKAQRQNRPIPQWIRLRTGNTIRYNAKRRHWRKSRLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0H1</accession>
    <name>A0A8G1R0H1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_396377</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515743.1">
        <property type="nucleotide sequence ID" value="XM_025656997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0H1"/>
    <dbReference type="GeneID" id="37160399"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH57821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="262" mass="28652" checksum="C3C23224689320AE" modified="2022-01-19" version="1">MFRNNYDNDAVTFSPQGRIFQVEYAQEAVKQGSVVVGLVNKTHAVLVGLKRNAEELSSYQKKIIEVDSHMGIAIAGLASDARVLSNFMKQQSLSSRMTYGRPLPVDRIVSQIGDRAQTNTQHYGKRPYGVGLLVAGVDDSGPHLFEFQPSGMTHEMVACAIGARSQMARTYLERNLDKLESTSRDELITHGLRALKESLSQDKELTVDNTSVGVVGLAGDGASGKIESFKLYEGQQLVPLLEALEQADAGETKEEETMEVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0M9</accession>
    <name>A0A8G1R0M9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-1,6-glucan boisynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_449008</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515818.1">
        <property type="nucleotide sequence ID" value="XM_025660070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0M9"/>
    <dbReference type="GeneID" id="37163472"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008659">
        <property type="entry name" value="Kre9/Knh1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05390">
        <property type="entry name" value="Kre9_KNH1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034063892" evidence="2">
        <location>
            <begin position="22"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="27"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1 C-terminal" evidence="3">
        <location>
            <begin position="175"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH57896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="264" mass="28587" checksum="BA3CE815BB949E2B" modified="2022-01-19" version="1">MMRLARTVVYFALSFLPTAFADIEFIEPAAGAVIRAGDVVTAHWRDSGALPRLASLVQYDLYLCAGGDTEGSNEDVALLVKDALFTRGNSVSFKIDPEVGGNDANAYFFRIAASGPETSVVNYSDRFTLTNMTGSFSPTVLNGIHSAIYSTDSFPSSLEDDNHEELRKRQVAGPFTIPYQLQTGPTRYAPMAKKPGSTIPAGTPTPQYPTSAYSVATTYLPQATVQMTLSASETYSVVSIENTASPAPHAGDTKMKRFLERWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R111</accession>
    <name>A0A8G1R111_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CwfJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_520296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515490.1">
        <property type="nucleotide sequence ID" value="XM_025665123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R111"/>
    <dbReference type="GeneID" id="37168525"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="3">
        <location>
            <begin position="307"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="2">
        <location>
            <begin position="512"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH57568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="568" mass="63322" checksum="A63F63BEEBD4DBC5" modified="2022-01-19" version="1">MASKIVVIGDVNCELQDVFTKLSKLHIKQNFSFAIIVGDLFGDCSTEHELEQISALLQGNIVVPLPTYFTLGSRPLPTRIIEAIESKDEVCPNLYFLGRRGTLKTSEGVRLVSLGGTLDPESKSSDKYHPSYTESDARALYGAHQADILITHQWPKDIRTGSKAPFPDTTDTPPTEVQCIADLCSTLKPRYHLSSSSAFFWEREPFFHLPTADTDNPDAKPLTRFISLAAYSKTTKTKWMYAFTLDPKAPPALTIPTGTTAPPFAPIPTKRKPLQSQRDSYHRFAVDDDDNNNRPRKRRARAPPPGPDQCFFCLSNPNIATHLITSIGDEAYLTTAKGPLPTSKTFASSSLNFPSHMLIIPFSHSPTLSSISDPTSRQSTYAEMHRYRSALHSMLRHRANNSLGAVTWEVSRGNGIHIHWQFLPVPADLVHRGLVDAAFKVEAENLKYPRFESPSQPNDGDESAEPGDFFRVWIWEPPQAAGAAAAASDTEARKDGEKGGDKGTEKTLLLPLSPDFRFDLQFGRRVMAKLMGLEKRINWKDDVQSVQEEEADAEAFKEAFKEWDFTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R131</accession>
    <name>A0A8G1R131_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_489127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514246.1">
        <property type="nucleotide sequence ID" value="XM_025663582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R131"/>
    <dbReference type="GeneID" id="37166984"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="96" mass="10769" checksum="02F5F4A21124C3FB" modified="2022-01-19" version="1">MPAINFPRSATALSHKTIGKRSWAGEEPGVILDFVVVFIVLCGILGLIIQKAWRNHFLKSSTHGGHVRRTLHVRKPLETLNPENPLIDFGQARIFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R197</accession>
    <name>A0A8G1R197_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">20S cyclosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_449315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516133.1">
        <property type="nucleotide sequence ID" value="XM_025660139.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37163541"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000217">
        <property type="entry name" value="20S cyclosome subunit (APC1/BimE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000400">
        <property type="entry name" value="20S cyclosome subunit (APC1/BimE), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="29"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 beta-sandwich" evidence="8">
        <location>
            <begin position="1789"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2038"/>
            <end position="2059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2038"/>
            <end position="2054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH58211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2091" mass="230018" checksum="72A665289E56FE94" modified="2022-01-19" version="1">MATVRSLGLHEPSAIAFLVAEGLLPPDPSEELYSWTTSVDRDSNGPVEDEIVWTRSCAVWSRAGVVKRVFRLDLEKEEIRHALLTRFAVGKIKRSESSVSESLKGEAAQPGSTSGRSRSSPDHLSAGISKGSLLMLGQNGEGSRDTSGTGANNARALVVVLKSQAHIFFLAGNSHVVPLPFEVDSVFATPKGLLIQRKLHEEESNTSLPAAPPNSFVSSLPDFRASQSLDIPSGKSKRPSLTISPAPKPGLKQRASKHADMPRVFSLMDPHSEMGLVVTNQSSRWLQTSVSTRPSGLDVLDPADAIVYVSPRDELSSSNRGLSIGPLILVVTVNINTGLYTIWTAHYRQDETAPSSKKKERRDTGGTRSKRRSSHFGMTTGTTTPAGRPSGARESFGPRSDGWNTSGLSLSQYSVEGKPDDDDLASKLGQDFGDIGVPLKTSRRVSSLLARADLAASQDRITFSDLATGSQSSSMPHGNFRQSLGAGSTRGSFGFNPRGSIPPGNGSVYSTTGSFVDAPVDRLLEELNNESLFEGFENMDLNHAASGLPEEVFLSKVESLSSKFSVSFQTPIKSKPSARQIKIMTLCPSEYGNAQSGNTAALALYLVDQEAKSMTVVSLRADKVAVSKKDAVFSKKPKKNPLSEERSLIVQASGIQHFADVWDACKIVDGGISRILTLKKTDGGEQVLQLQTPWSKATPIQVPRKLMLHEAYGINPKTSGNRRRESGVKRLMTDSPITVTGFDHAAARGKFDVIDSENRKVKLQVQMEPSNELVKRLLNVCRFALSDEKAGDGLLAAWWETMAWLQERETSENDLEWTAMVVILFAMAIQFIDSEQPRTPAKPTRRKKGLLRSSSGSHVDLESWETMLEQESGSGGVVAPWMASSSWAWVVEQDAEDNEVSHGHQVPSSRSTCRTNTYLLRCIALTRDFLNTSRGTLSVGSGGYLPTALSFNQSIRGTALCTILVALHLFREEQKLSICDSEQSGKPLGLLAPVLAQLGGWLGWQSWAWAEDAYYGMEMASMERWQFEETRISMLDLPAEPFPPPSIFAHLETAWRQPSDSFFTLLNLVTSPDRPPKKGRLWKECFTLTPRTLALDGFLSEVHNLAAPFDRVKLLHRWGFTRSIIESFPEGVSAPLYEAIMQSQMHASTSWSSTLLELIDREDLSISMGRNKPWLPSATSSLQPAVSHDAIRDVHHIGTSALDVDATNSFEASAEADRFSVTRLIFREDKRFIDAARLLNQSKAPVAECIPEPEWTDSDLLEAQKEVVQLVTLRTLSIPTGRAMLTFSGRLPLLTEKLPIPSFSLQCVMKPSNVTISADRASFSEEKVCWAFFHNGVSTGLAISKSSKGIDTSWILFNKPQELTNRHAGFLLALGLNGHLKSLAKWVAFKYLTPKHTMTSIGLLLGLSASYLGTMDTLITRLLSVHVTRMLPLGAAELNLSPLTQTAGIMGIGLLYCGSQHRRMSEVMLSEIENVEQEEGSHEDLRDEGYRLAAGLALGFINLAKGKDLRGMRDMHIVERLLAVAVGTKNVDLAHVLDRATAGATIALAIIFMKTNDEILAQKIDIPDTTVRFDYVRPDLFLLRTLAKHLIMWDSIRSTDDWFIQSLPPVYRRRYRLTGVRRLKSDDMPFFNIVAGLCFTLGLRYAGSAQTSVRDLLLAYLDQFIRICRLPAVNYDAKLARNSVRHCQDVVALSAAAVMAGTGDLALFRRLRSLHGRVDADTPYGSHMAAHMALGLLFLGGGSYTLGTSDLAIASLICSLYPIFPTTVLDNKCHLQAFRHLWVLAAEPRCLVPRDIDTRRPISIPITLTNQDGISRKITAPCLLPDFNSLTRVEICNADYWPLVLDFSKDPSLRQKFHQGDQSIYLRRKATYNPTGSSVFVSTLSGLSEAQDVLPSSTSASNHGKGLPPAAMPNLATLLTSGVNRTPTSPTQSMWEWIFNLPSLRGLDVREKSLVLPSSFFPTINSTSNSNTTALSYAPWLRQSAVDSKLVLEAIVKNTIQAARGRAADPDEVRDRIWQLRLLFNWIDASSSSSLSSAEERFAERQREEQERSENGGLLGQVGASDGLWLRRDYIEEMRWKIWGVQIGDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1E8</accession>
    <name>A0A8G1R1E8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endosomal/vacuolar adapter protein YPT35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PX domain-containing protein YPT35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_51342</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPT35 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514411.1">
        <property type="nucleotide sequence ID" value="XM_025664707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1E8"/>
    <dbReference type="GeneID" id="37168109"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07280">
        <property type="entry name" value="PX_YPT35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037917">
        <property type="entry name" value="Ypt35_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="114"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH56489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="227" mass="24919" checksum="9C7AC38ACDC8D53D" modified="2022-01-19" version="1">MEPANEDIASVPPHQPRPSSPTQSSSPPSDIINNDTIAASLSDGVAVSNGSILPRAQDLSNKDRPVSGIVPPYWSHHRNASRASHISLDQAPGITLEDHTEDPDCETSRGLWAKSVVVDDHVVVQGKTGIGSYVVWNCRIQTLDGGPITVRLRYSEFDDLRQRLVASFPHAKNALPPLPPKSVIFKFRPSFLESRRVGLEYFLNCVLLNPEFSSSPVVKDFLFGRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1F8</accession>
    <name>A0A8G1R1F8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cullin binding protein CanA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_307642</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515561.1">
        <property type="nucleotide sequence ID" value="XM_025655392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1F8"/>
    <dbReference type="GeneID" id="37158794"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="855"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH57639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1035" mass="112551" checksum="A683AB06D316574B" modified="2022-01-19" version="1">MSSYDDEHDPQADELRETALVTLETLISSCNSQMQPYMSNTINSALRFLKYDPNVAEAEDDEEMGGTQDDGSEDDVTEEPDLDDDDEFEDFEEEGGYSDIDDMSWKVRRCAAKLLYSVISSYTRGRTADDASLFQQISPALIARFNKEREESVKLEVVSTMTALVRKTGEGAMIITSNGFLESVGGSKNSRKRRRQDSDASMIDFEPSIGTSSAVSTPVVAPSSPNSGPQAELARSVPIIVQSVVKMWKQASVPLKQAIIVLLKSLALVRYGGLADHLQQLEDPIADVLKSSSLSGGSSAPVGSSASAGTLQTETLGLIAAIAETHTSDALLPFLIALIPGVIGAVNDRNYKVSSEALGAVEQIVKALTPPRVPNASQDLASHLGRLYDVVHTRITDTSADLEVRQRAIHVFGVLLARTAGEKGSSFLPLDQRSKGLSVLVERLKNETTRLAAVRAVDDVAVLCTREVDVAPTWVSEVTAELGAQLRKSDRVLRGASLEALRSLAMNPNTRTHYDDKTMKELEDSLLPLISAEDFHFLAPSLIILAKLVPGNAQLLVNESLISALCSVVLSSLVGTVLKALLLLVKVIGEEGAGAALMKKLLQDVGISGDTSVVGRAIGTLLVHGGPKLGVKMEDFMTELETAQDAQRKCLALAILGEIGLRMGSSCSLTPELFITHFNSKSDKVRLAAATALGNAAAGNVKSYLPIILGGLEKGNPQSYLLLHSVRELLQHPEIVRPDVAPSAVKLWQALLVVSEEEDNRAVGAECVGRLALIDPVAYIPHFQDYLSSSDPSIRSVVISAFRYTLSDPRDTYNDVLRPVIVPLLVNMLSDRDLGNHRLALTTLNSAIHNKMEILVPHLNELLPAVFGDTKVKPELIREVQMGPFKHRVDDGLELRKSAYETLYASLDSAFSLSHMSEYFDRILSGIDDEQDIRTICNLMTSKLIHLAPEETQRHLDALSERYNAILSFKPKDNAVKQELEKAQEASLGVLKISRDLSKAFPNAEVAGDHHKWKAYMELIRKTYGAQLKTLEAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2G3</accession>
    <name>A0A8G1R2G3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Serine/threonine-protein kinase PHO85</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_449418</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515358.1">
        <property type="nucleotide sequence ID" value="XM_025660162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2G3"/>
    <dbReference type="GeneID" id="37163564"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000524">
        <property type="entry name" value="Cell division protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000062">
        <property type="entry name" value="PHO system negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="9"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH57436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="313" mass="35654" checksum="9D94594399A3C233" modified="2022-01-19" version="1">MTRTSPNSFQQLEKLGEGTYATVFKGRNTKTGELVALKEIALDTEEGTPSTAIREISLMKELHHENILRLHDVIHSENRLMLVFEYMDKDLKRYMDTNGGQLEPSVIKSFANQLVCGIAFCHENRILHRDLKPQNLLVNHKGQLKLADFGLARAFGIPVNTFSNEVVTLWYRAPDVLLGSRSYSTSIDIWSIGCIIAEMSMGRALFPGSNNEDQLQKIFRVMGTPCETSWRGVSRLPEYRADFPLYVEQDLWGLMPSMEERGMELVRAMLKLQPEMRISAVDALNYSWFTNGELCDKEVRAIFARAVEGQRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2L1</accession>
    <name>A0A8G1R2L1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_373933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514562.1">
        <property type="nucleotide sequence ID" value="XM_025656106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2L1"/>
    <dbReference type="GeneID" id="37159508"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="381"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="784"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH56640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="836" mass="92897" checksum="040AA5D3C95AF203" modified="2022-01-19" version="1">MKENCVYENLVRDKFTGRVRRVSPPVPQGENSIEQEFIANHSEERTGSSTWSHCVSQDSEKVIDLSDEAPLPRGTVSSTAPPPPPPPPPHTPPTEPICDARSAPHQRLSSSILTPAPRSSQQEVDLQYPTMPSSEEAIQLPEDHQAFARAGRSRTPSAFQHAITAVSAFATAPSASNNHHYLVSPDYLSVRRGARARYIGHAFWGFVAGKESMSDDFFDCNRDASPERPLKHISSLGMFSLLRSLPTKPVSDTFLDAFFFAVWPLFPLVHSPTLRADYDRFWDWCRNSDRALPPEKVRDDPTFLCLLFAILYSGACAAPPASWTCASLQSLRRETTIAHLKSAYTTSMSLCQHLDHPTLNTLVSTLLTAPFLDRDVEPMRNMVSISTTIRIAQSMGLHMEGSWSSSLSPVDQEIRRRVWWYIIGLDVQSSICTGLPPCCAPETLDIVSMIADTRDEDISDMSSHFSPDLVPGPAEQSIAVILAIARSVTARVQSKIISRLQNGRHLNQTEFTELVMLVKDLQQKIDKLVARVPSQGIPEKGFIPSRLAKASPITHRTLYKDDGTHPTVFAAWTRIMLILIKFETAVILQKPFLPAPDSADPESCRAWTSVAHLCVSYLRMFLQLYQTPAYSPYVWFCYRYHGPLQCVFLILVYLHCFPESGDIVLARYCIEEIIDHTVSYYQDPQGSSGVPRADNPDCGEGSSEARIPLAVQVLVDLKSRLDSQMKSDTRIIDKLDENKCRLSPYALEPGSRSTEKDTVNKSIFPLPYSSFSSSTIHIHCNERAPSTATAPQTPSGTRPGLTSSIFVAEDDSGLDLDVLTSLTDFESWSSSLARPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2S2</accession>
    <name>A0A8G1R2S2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sister chromatid cohesion acetyltransferase Eco1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_370778</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ECO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516125.1">
        <property type="nucleotide sequence ID" value="XM_025655972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2S2"/>
    <dbReference type="GeneID" id="37159374"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="11">
        <location>
            <begin position="178"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="12">
        <location>
            <begin position="351"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="78"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH58203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="422" mass="46685" checksum="4EF9B1D17D82B95E" modified="2022-01-19" version="1">MPWTVTNSFKRGLMMKTYGRPLWRVYDDDQRPAAKKRRVQSGNDSDEAENSIQYAIRESSAAIMSSPSRRNSILLSEGTQEDDLSTPPSSPPPRLSPPPANTRKPTFAFLKRKQSATKDASNGTPVTNGTTTTTTTTTTNGTTNGTPLTEVNSNSVRASVDPPKKKAPQPQQPPVLKQMQIDLGHEVRRTCATCGMEYVPSNTEDAALHKKFHDMNSTGVDLGKAFMRANASRWVYEATRFDEGYVVIVDRKASPTAKNQAKKVLEVICKELSSPTIEDEVLWSQTEAPKHLQQNGVPEKVDRYKVFLHMKDSRCVGACLTERIWESRPVKKSAVSGNGPDSSVTVGEERHPAIVGISRIWTSGSSRRKGIAMDLLDCVVSNFIYGMEIPKEQVAFSQPTESGKGLAQSFFGNEEWHVYEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2S7</accession>
    <name>A0A8G1R2S7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_488198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515384.1">
        <property type="nucleotide sequence ID" value="XM_025663510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2S7"/>
    <dbReference type="GeneID" id="37166912"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="240" mass="26490" checksum="F474E55A46AAB7F8" modified="2022-01-19" version="1">MKINAELEFPLRDGIPAFNHDATDRDDENDTADNTNKSNEDEPYYLLTMSTRPTAHRSIDTDDYANELNEDELCCLLTMSIYSTAHRLIDTDNNTNKLNEDKPLRPLTTSTRPMACQSVGTDGFLSHDLSPILPSTAPSRLSSKNNSPLIQHAARRSTTGFTAINATTRQAALPGWPSSPDPTILINNFATMHGTLEDAFSDLINYPADKPVIEPVVEDINDEIELDGEIDVEPAVKETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2V2</accession>
    <name>A0A8G1R2V2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_459398</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516170.1">
        <property type="nucleotide sequence ID" value="XM_025661653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2V2"/>
    <dbReference type="GeneID" id="37165055"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="536"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="590"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="717"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="667"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="718"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="737"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="775"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH58248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="895" mass="98526" checksum="16246D3CDFB86CF3" modified="2022-01-19" version="1">MAWCHLTSQWGIASGHALLTIRDSERQDLVDATHLGVALRHACPLRTSDDVSRLRPCLLISPPIRASDVCFASPDTPRTTAEHFNLPIPSMPSPDLSQPGQFSIDAPTDDGQIGSGMSNISGDYGAVASETSSGQGSGGSDAIAEGKQNAKAVLAASGVPLGSTESAHDASNGNPSPLSQANSANGSASSKKRSRDGSVINSSQSTEGLPVRVRETPADKILLEDYVNREFHHSALTAWQNPSQELLHQKRAERDYFLAVRRENHMNPAALYGVGYEGFGNQRTDLRNQHPQLLYPANRRRPGNRRTRELRISRKDLKTQNEQIEDLVPIRLDIDWEKIKIRDTFTWNLHDRVISPDLFAEKLVEDLQIPIESCAPLIRMISSSIQEQLCDYYPQIFMEEEPLDPHLPYSAYKNDEMRILVKLNITIGQHTLIDQFEWDINDPHNSPEEFAERMTDDLSLSGEFTTAIAHSIREQSQLFTKSLYILSHPFDGRPIDDPDLKTAFLPTPLTSSFRPFQAAKEFTPYLYELNETELERTEVSISRDQRRQKRSVNRRGGPALPDLKDRQRTIRTMLVSTVIPNCAASLEDSNVYKRSGSSRSRRAAVGLRDTGEESEESDSDESSITGSPAIGPHLAQGTARTRGMRGAASAAHAALRASLGQSATPEPHNEARAASRRREIREESVVEEPDKLLVKLKISKEKFRQFLTHGLQSIQGLATPAAQPASQQSTPQVQTPTPNPMAPPAAPQPEVRVPSVPPPGQRPVPAQQIGAVDAPHPPQPGVPGPPPPSWLAAGLARLKLSYPNDSFEGVMRYTAVDTETMLPVANSNSQPGHKLKYQYLPRIRCHDCPGKLYTPGPGTTVDNFEVHLRNRQHKERVEERVAKTAAVAATGGNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R340</accession>
    <name>A0A8G1R340_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_273587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516290.1">
        <property type="nucleotide sequence ID" value="XM_025655119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R340"/>
    <dbReference type="GeneID" id="37158521"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="80"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="328" mass="36648" checksum="09B8CE6B3BD625C8" modified="2022-01-19" version="1">MLSQRQQPQQQQGLHRPSPRVLSTKRLHSHHPDSFSSRYRAGKAKPRSREQSVAASRRLHRSRHTPDTPPDGSNSSLSHGVITLTIGPTKRLFAAHKDILCVSPYFAALCNPPNNDTSSSSSPSSSPSSSPSPTKSMKTIDLPDEQPEIFSCVLEYLYRGDYYPRLRHDKSTNTWDLETTTTSSSSTPNTRNNTTTNTKDTTDPSAIIFHPAVGAEILRDTAVYCAAEKYSLEHLKRLSLKKQGLHSNIPCHIILSSARYAYMHTPDTESKLRAHYLALIIRSRGTFKRSGTMQMEMERGGKLFFDLFVAMCNHMDDLEEAARGEGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R347</accession>
    <name>A0A8G1R347_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_371883</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515703.1">
        <property type="nucleotide sequence ID" value="XM_025656013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R347"/>
    <dbReference type="GeneID" id="37159415"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF2">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034074310" description="LysM domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="55"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="139"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH57781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="188" mass="19475" checksum="CE06C525E3F0B7BD" modified="2022-01-19" version="1">MYLTYITLFTLLSLASAAAHIPRDGTPTTLIAAAAINAVATPSPIQPGMTSNCDSFHLVSSTDTCVTIASSVGITLANFYSWNPGVGSSCDTLWLGYYVCTGVSDTTTTTTTSTTTTSTTTSVTTPLPTQSGMVSNCDAFYLVASGDTCTTVAQKKSVSVTDIIAWNPAVGTGCTNLWLGYYICVGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R487</accession>
    <name>A0A8G1R487_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_497336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514467.1">
        <property type="nucleotide sequence ID" value="XM_025663991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R487"/>
    <dbReference type="GeneID" id="37167393"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH56545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="380" mass="42384" checksum="B11EE2735A229015" modified="2022-01-19" version="1">MNARSDSDVPYNGDALIGVSVAIAVVQIVVVIARFYTRRRLQQLAFALDDYLILLALVLAYLSGYYGFVLTFLQIASLGQSALYIILVKLAGVGHHMEYVEETPAKLVILEKGLYANEILDFPFTVTPAKISILVFYLRIFTTRSFKIMAYIVGAIVLGHGLGILFAAIFQCWPIAYVWDKTIEGGSCFNQLAFYRYVSPPNILTDVLILIMPLPYVWKLHTRKGQKLALTGVFLLGSLGTVASILRMTIFFQENATTDPTWTSTNLGIWTILEGGIIIIAACLPPIWPLIMRILPQQLRSKGSSQTPQRYYQRRYPTNQANGKTPEGFSRLGDNSQSRGSHVPSLGSQTIVARESEYYSENISLEEAVHGYRVVEREGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R516</accession>
    <name>A0A8G1R516_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="8">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_468525</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="8"/>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515792.1">
        <property type="nucleotide sequence ID" value="XM_025662269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R516"/>
    <dbReference type="GeneID" id="37165671"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000004">
        <property type="entry name" value="Purine nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="10">
        <location>
            <begin position="31"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="92"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH57870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="307" mass="33219" checksum="20812759016A24CA" modified="2022-01-19" version="1">MRQIPSSSFQHASEACSFLKERLPDSLKAPRVAIICGSGLGGLASTIDRLPQVDFDYASIPHFPRSTVAGHAGKLVFGLLSENIPTVLMVGRAHYYEGHSIDQVTFPIRVFKLLGVDTIILTNAAGGLNPEYMVGDIVLLNDHIFLAGLAGVHPLRGPNSEEFGPRFPPLSDAYDLQLRCNVHKAWAKIVNVESKRRLHEGVYAFVGGPSYETRAECRMLRQLGADLVGMSTVPEIVVARHCGIRVLALSLVTNNAVLSPVPRGDDHRLDGKDVAELGEILQVGKADHQEVLEAGRSAATDMQVCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R552</accession>
    <name>A0A8G1R552_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_447623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517680.1">
        <property type="nucleotide sequence ID" value="XM_025659759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R552"/>
    <dbReference type="GeneID" id="37163161"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="97" mass="9149" checksum="9E02BCC612E26CDB" modified="2022-01-19" version="1">MRKYIANLLGGVGDTLGKTVGGLGDTVGSTVGGLGDTVGNTVGGLGQTAGGATQGLGKTVGGATEGLGNTTRGVGQSTGDILSSINGDRSGANADRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5S7</accession>
    <name>A0A8G1R5S7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional adapter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_447882</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH60024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517946.1">
        <property type="nucleotide sequence ID" value="XM_025659804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5S7"/>
    <dbReference type="GeneID" id="37163206"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02335">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000115">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000008">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041983">
        <property type="entry name" value="ADA2-like_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016827">
        <property type="entry name" value="Ada2/TADA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF20">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025024">
        <property type="entry name" value="Transcriptional_adaptor_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="12">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="14">
        <location>
            <begin position="77"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="15">
        <location>
            <begin position="82"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="13">
        <location>
            <begin position="432"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="131"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="334"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH60024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="520" mass="58797" checksum="B12287D67B00C0B4" modified="2022-01-19" version="1">MGVIRKKTASRGTEAGTKYHCDICSVDVTSTVRVSCAHPACHEYDLCVPCFAAGEKSKNHDPSTHPFQVIEQNSVPIFEEDWGADEELLLLEGAEIYGLGSWADIADHIGGYRTKEEVRDHYISAYIDSPNFPLPERADPDDKRLSEAISKEEFQARKKRRIEERKEAAKAAPPTTPKQKPTASVPACHEVQGYMPGRLEFETEFMNEAEEAVQHMTFEPGAGETANGETDAEMELKMTVVDIYNSRLTARTERKKILFEHNLLEYRKNTALEKKRTKEERDLLNKAKPFARMMNHDDFEEFNKGLEYEHNLRLAITQLQEWRQMGIGDLKGGEKYEQEKQQRAQRMVPQGSFDRFASTRPTKQSQQPEQPSAASQLTTPELPLRLQKASGAPKAPEPVNPPMNDFDRAFAATNGDGITTPQPVKTKFVIQPLNGVIPWKLENEGAPDLHLLTKEEVEVCNVLHMQPKPYLVIKETLLKEAMKQGGSLKKKDARAICKVDSTKTSRIYDFMVHSGWINKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5X8</accession>
    <name>A0A8G1R5X8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter Seo1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_418535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517173.1">
        <property type="nucleotide sequence ID" value="XM_025657820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5X8"/>
    <dbReference type="GeneID" id="37161222"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF15">
        <property type="entry name" value="TRANSPORTER SEO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH59251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="493" mass="55334" checksum="A7D5FD078FCEAAD9" modified="2022-01-19" version="1">MFANKRFPRIRWFSPDDSPSERRLLLKLDLLIVPYAFLAYWTKYIDQANINNAYVSGMEESLNLQGNDLVNLQTIYTVGAVLGQLPFAYLFTKYPISYLIPGMDLLWGVFTLLQYRATSYEEMMAYRFLVGWFEAAFFPGMHYIFGSWYQSHEIARRGGFFYLGLTLGTLTASFIQAGASAQLDGVNGLAGWRWMYIICAVITIPVGILGFIVLPGTPDKPNRIVLSKSDIQLVRTRLQKAGHGVQESSVSWKTCARVLRNWKPWALLCVDILFWNACVQTTTGGYLLWLKSLNRYSTSKVNELFAIAPGLGMFYTLLVCFASDLLLGPAWAITLAHGWNIIGLVIQVIWDVPESALWFAFSTMYSSVAMSSVLMGWINSEIRHSPDERAIVLIVLNTIAQSTTAWTPLLVFPTVEGPRFTKGYSFVLACAICLIVSAHVTRYFIEREDRAIAASDEDSGASRDERESGSAVVQVARPKAEYRYTDGEGIDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6Y6</accession>
    <name>A0A8G1R6Y6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_436591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517559.1">
        <property type="nucleotide sequence ID" value="XM_025658580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6Y6"/>
    <dbReference type="GeneID" id="37161982"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="121" mass="14181" checksum="99923826CF698153" modified="2022-01-19" version="1">MDWPRHMGILLHNGTYQSSIMKRHAKRPVVPSYGVATDSNDWVYLKIDQELIESSIETLLNLSPEVVTRLWDHQKRLNNSEVQVDYTNEELAIITITNLDYPRIPRIVQSCSSRFWQRTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6Z4</accession>
    <name>A0A8G1R6Z4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_438142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515832.1">
        <property type="nucleotide sequence ID" value="XM_025658656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6Z4"/>
    <dbReference type="GeneID" id="37162058"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="211" mass="24122" checksum="8E7858A0C6FB1497" modified="2022-01-19" version="1">MAQHASAILTTREYPKTLLPYTHVAVTTFRKAHDMPKDRNTDTPTKARNRGRQHADAPSPPEPKHRRKSTPEPTLDKPDITDHDVKKNKISCFIYTPAHVSWTLRTLLVSGGITDTFDDETCLTYLLRGSPKLRALLSNLQQEVFELNEKSIVWCTGPSQQMYMAAALHHAHIDCQVYHSELTVKERMERMHGVNMQLLRQFCWSESSTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R778</accession>
    <name>A0A8G1R778_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_457392</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518495.1">
        <property type="nucleotide sequence ID" value="XM_025661514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R778"/>
    <dbReference type="GeneID" id="37164916"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH60573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="158" mass="17879" checksum="2FD322D3BE49FE8D" modified="2022-01-19" version="1">MSPISVFRVATRAVRPSGFIRAAQLPRPRVQAPVALAIARPSFSTSAKRFGGHHEDETYEEFSARFEKEFDGVQDVFELQRNLNNCFAYDLVPSVEVLTAALKAARRVNDYPTAVRIFEGVKAKVETQEQYKQYLEALEGLRQELGVALREELYPEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7A7</accession>
    <name>A0A8G1R7A7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase catalytic subunit A</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Vacuolar protein sorting-associated protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO85DRAFT_457432</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Vacuole membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518540.1">
        <property type="nucleotide sequence ID" value="XM_025661517.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37164919"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055082">
        <property type="term" value="P:intracellular chemical homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000473">
        <property type="entry name" value="Vacuolar sorting-associated 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="20">
        <location>
            <begin position="695"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="19">
        <location>
            <begin position="1269"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="18"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1194"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RAH60618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1356" mass="149960" checksum="7895CB7054FC5AFD" modified="2022-01-19" version="1">MLGLGVRRLKARPSLLDLIAHHEGDEQPVGSRSSSPPGLDSPQLPPLPVSPTSSSCSDSSSSSSSPPSPIHPSPSPALSTPVIHLPASRTMAPSADAGESQHGSVFSVSGPVVVAEHMIGCAMYELCRVGHDQLVGEVIRIDGDKATIQVYEETAGLTVGDPVTRTGKPLSVELGPGLMETIYDGIQRPLKAISDQSKGIYIPRGIAVNALDREKKWDFKPGKYKVGDHITGGDIWGTVFENSLVNDHKIILPPRARGTITRIAEAGSYTVEEKLLEIEFNGVKTEHSMMHTWPVRVPRPVNEKLSSDAPFIVGQRVLDSLFPSVQGGTVCIPGAFGCGKTVISQSVSKFSNSDIIVYVGCGERGNEMAEVLMDFPELSIDVDGRKEPIMKRTCLIANTSNMPVAAREASIYTGITIAEYFRDQGKNVAMMADSSSRWAEALREISGRLGEMPADQGFPAYLGAKLASFYERAGKSNALGSPERIGSVSIVAAVSPPGGDFSDPVTSSTLGIVQVFWGLDKKLAQRKHFPSINTSISYSKYTTVLDRYYEKHHPEFPRLRDQVRELLTKSEDLDQVVQLVGKAALGDSDKITLDVAAMVKDDFLQQNGYSDYDQFCPLWKTEYMMKAFMGYHDEAQKAVAQGQNWSKVRDATTDIQSSLRGMKFEVPTNEAEVSEKVSQMPPFFTCSIANSQYISFHSWKVTINLSNVVRSKPHRSASDCRRRLPRGSGIVTRRPLVLQLINRPAGSQTNGVKEEALETTDKEANIDEYGEFLHIPGQKFYDFNKIREEIVRETESKVGRNAGISPAPINLRIYSPNVLTLTLVDLPGLTKVPVGDQPKDIERQIRDMVLKYISKPNAIILAVTSANQDLANSDGLKLAREVDPEGQRTIGVLTKVDLMDEGTDVVDILAGRIIPLRLGYVPVVNRGQRDIENKRPIAYALEHEKNFFEGHKAYRNKSSYCGTPYLARKLNLILMMHIKQTLPDIKARISSSLQKYSSELSQLGDSMLGNSANIVLNIITEFSNEYRTVLEGSNQELSSIELSGGARISFVFHELYSNGIKAVDPFDHVKDIDIRTILYNSSGPSPALFVGTTAFELIVKQQIKRLEDPSLKCISLVYDELVRILGQLLNKSLFRRYPMLKEKFHAVVIGFFKKSMEPTNKLVRDLVNMEACYINTGHPDFLNGHRAMTIVNERQTAGKPTQVDPKTGKPLPPRANSPSVEVPVDNSNSGGFFGSFWASKNKKKMAAMEPPPPTLKASASLSERESVEVEVVKLLITSYFNIVKRTMIDMVPKAIMYTLVQFTKDEMQRELLENMYRNSELDDLLKESDYTVRRRKECQQMVESLSRASEIVSQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8Z7</accession>
    <name>A0A8G1R8Z7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7582 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_417939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516882.1">
        <property type="nucleotide sequence ID" value="XM_025657789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8Z7"/>
    <dbReference type="GeneID" id="37161191"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056004">
        <property type="entry name" value="DUF7582"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24483">
        <property type="entry name" value="DUF7582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7582" evidence="2">
        <location>
            <begin position="40"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="319" mass="36093" checksum="1EAC35AA94201316" modified="2022-01-19" version="1">MGVMRLPRPTGVYVPNSPTRSLKGDMISSPLSPEFNFDSETLTPSIIPALEYVSSKLEQRMMHVTLLVGRGKPYPTGQPSDLIVIPITPLDEAAWRIVFRTVAKGASKFSLGHSWTDALNRSQHERQAHDYLIQQSIMQNEVIFSREGLTLLNVDRIYTLKRRLCILSHRGTPPEESYISSCAQLLHRTINDFHGRPFSRAFFHRVYEQLDVPDMLLSQVADAFRKQYKQEGIIIPPPAKADVERPRKSPLRATRAARRQNPPPTRYNLPTKRGPKTPLSASDVTPITRNEWNMLRTDFPLGKSTVTKWTPSPTVMAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R935</accession>
    <name>A0A8G1R935_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import receptor subunit TOM20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mitochondrial 20 kDa outer membrane protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import receptor subunit tom20</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Translocase of outer membrane 20 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_485128</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519319.1">
        <property type="nucleotide sequence ID" value="XM_025663300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R935"/>
    <dbReference type="GeneID" id="37166702"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.10:FF:000002">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH61397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="210" mass="23749" checksum="132FA6EFAB70B983" modified="2022-01-19" version="1">MIPAKLSGQQKNRRHLFTSLFLVDFPFRRFRLFPIFTFHPTFIMRTSTLIAATAGTIVTGLLAYAVYFDHKRQTDPEFRKALKRNNRRMARAVKEEAEAQGAMQREVIKKVVQQAKDEGFPTDLEEKEAYFMSQVAQGESLVAEEPIEAALCFYKALKVYPQPKDLISIYDKTVPKEVLEILAEMVALDSGLKLGSFTGESAAPESHGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R972</accession>
    <name>A0A8G1R972_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Apoptosis-inducing TAF9-like domain 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_196675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TAF9 family. CENP-S/MHF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519364.1">
        <property type="nucleotide sequence ID" value="XM_025654480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R972"/>
    <dbReference type="GeneID" id="37157882"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22919">
        <property type="entry name" value="HFD_CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000098">
        <property type="entry name" value="Apoptosis-inducing TAF9-like domain 1 family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029003">
        <property type="entry name" value="CENP-S/Mhf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980:SF0">
        <property type="entry name" value="CENTROMERE PROTEIN S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980">
        <property type="entry name" value="CORTISTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15630">
        <property type="entry name" value="CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH61442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="102" mass="11500" checksum="F6C1B237C782A185" modified="2022-01-19" version="1">MEQNEEVNLEERLKSALWLSIGKIVDEETIKLGVNATPQFIGALTEMVWAQIETVSQDLESFAKHAGRSTVNVADVMLLARRNEGLESILRAFVEQQREEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9R2</accession>
    <name>A0A8G1R9R2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN-binding flavin reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_412360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519664.1">
        <property type="nucleotide sequence ID" value="XM_025657566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9R2"/>
    <dbReference type="GeneID" id="37160968"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43812">
        <property type="entry name" value="BLR2425 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43812:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="240" mass="26449" checksum="6440EF2152D39B79" modified="2022-01-19" version="1">MFYQPGKTDHGLPHDPFKACVVPRPIGWISTTSPTGAPNLAPYSQFTNLTFDPPYVLFSSNQTVTGDRKDTVVNAESTGSFVWNLATWDLREAMNITAQQFPYGVNEFEKAGLTAEPSTVLPVEVPMVKESPVRFECVYHSTMRLPANPPMGTVDVVVGRVVGVHIDEGVLTDGILDVKKTKPIARCGYFQYAVVEDTFEMVIPGMSKDVLYGLEGSARMNGEKAREMEGKEARKERGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAE6</accession>
    <name>A0A8G1RAE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_475493</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519329.1">
        <property type="nucleotide sequence ID" value="XM_025662731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAE6"/>
    <dbReference type="GeneID" id="37166133"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000017">
        <property type="entry name" value="Synaptobrevin-like protein Sybl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="12"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="159"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH61407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="256" mass="28387" checksum="B05BE66B3DD1394D" modified="2022-01-19" version="1">MAASSSKPSSFLLYSCIAHRTTILAEHSSPGTSSSAASSLASIILPKISHDQPQKLTYTHERLFVHYIADSPTTPSTPDDPRQGEPNSYAPLSYIVVATAEQGRRIPFAFLLEIKRKFLTTYSPSSTDFSALPAYGCAAFNNELRSLLQTYNTAPPADSLASAKREIDSVRNIMTENIERVLERGERIDLLVDKTDRLGGSAHDFRIRSRGLRRRMWWKNVKLMVLLAVVVVFLVWLFVGMGCGLPAWGRCVGHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB28</accession>
    <name>A0A8G1RB28_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">2Fe-2S iron-sulfur cluster binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_443938</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520520.1">
        <property type="nucleotide sequence ID" value="XM_025658901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB28"/>
    <dbReference type="GeneID" id="37162303"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="88"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH62598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="203" mass="22217" checksum="FE217D32AB61069C" modified="2022-01-19" version="1">MSFWKEACLNLRHAVPKAGNSIGRTQSKQFLTSSYSTQTPGVIASSRLSINARRNFLSQQSWMARRSFSVTAGAQHGHITPPKPGEEINVTFIDKDGVKIELQVSEGDNLLDIAQANDIEMEGACGGSCACSTCHVIVEDPDMFDKMEEPSDDENDMLDLAFGLTETSRLGCQVAMSKDLDGLVVRLPSMTRNLQASDFEPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBH9</accession>
    <name>A0A8G1RBH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_434117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521548.1">
        <property type="nucleotide sequence ID" value="XM_025658451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBH9"/>
    <dbReference type="GeneID" id="37161853"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="158" mass="17102" checksum="CC3AD0A820D1259A" modified="2022-01-19" version="1">MSSWLPWQLGQLPLGKCKIANFPGAIHEQGGTPLKLISLNFLALRCYCFGDSKHYTSKLAREWELARNLRPSLLGQSQLRAEQSHAYIAGQSLCNATHMPVSGPTRSSREDPMRSCPSPDSALVTASDSSKLVDGDGWSGWCFTLQATGNVAGSAPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBS3</accession>
    <name>A0A8G1RBS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentatricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_444565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521186.1">
        <property type="nucleotide sequence ID" value="XM_025659043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBS3"/>
    <dbReference type="GeneID" id="37162445"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="933" mass="107094" checksum="C5E06F5B11D67C7A" modified="2022-01-19" version="1">MVSKPTSGTPAVPSRNALRVLRRLALAGSTVGSFCTVAAITYDVHRRVRVAERIVENKRALQTSAPNYDATSAARRLARMMEAAEAGEFMGLESLKEQDRKFREAQAVPAGVDVRGDDLSWDVQLQDQQPSAPAETYMDTARSKLIDTFTPGQAPANSTSAPNLPPNLTRSTDALDRAKPALANAKQRTTEGHEKQTEDVAQWHDSVTEEMQKFLDHGRPIDAAHLFLDAHPATLNGISTDRREVTVKTFYANCREENVMVARNIFERLEDVDKVSPGMWKVLMFALARKGSIESVATIFTRYMHKFKVPPEMVDIVLRCLLESHRLTTAKWFLLRNLEVDRGCGLCGAYLAGLWKKTRSIELLNGQLKKILTILPRLGKEPTDKLFNPVIKAYVEFGRLADAEALVKDMTTRYGIPLRCRTKGLLVFGRALACDWEGVDAGLQQMHELKLTSRKYDFTPIFDRIFLEYWVSHSGEEIREFVYRYIEKFQMVPDKILYKHILEAFVEKGNKEMVDEFVRFARERRWPNFINEQEFLEMLRKRRHALEEAPVGFWQMLQAARAKYGQAATSQQVLGYDQRSFPLAEVNLMPYTQDPLPWYQRTLQHMTPSRPVDQYQKLHKQMSHYMHVGKLTEALKCFENAKNARFQFKQLHVELAVICTLLEEGVGAARALIDSEWKNIRHLVRFFPQFFRQIMEVDSEAEGQLINMAVLRFYELCWSNKKMTVKHHITVATSRRLIAVKKPELAVDLLATVYMSRFRHSLAYDGVCMKMFIRAFAATGNLHGMRWCILTALARGSALNRDFVIEARRVTGNLQRQLSSAEGSKDASRDMEKIEYLTHAVELLEKKSQGDPQLWQLKTNPTVKKAGRRLLKRPLDERRLYKKAHLQETIEGWDEEYELEAVLGRIDIDPKSIALRWSEKHCLGQIREIDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCA9</accession>
    <name>A0A8G1RCA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_135286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520349.1">
        <property type="nucleotide sequence ID" value="XM_025654033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCA9"/>
    <dbReference type="GeneID" id="37157435"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="200" mass="21982" checksum="DFB5A0801DA7A7C9" modified="2022-01-19" version="1">MPVADIMRAYQLGSAAACVPSSARTARQEDHPHPVGYQSHRRTQVNYGGKSTLQKLRQLITTPLFNQNSLTMDSRAQLSLMGKGSTTIVGGHATIGSFSADVLAFFLRRIMFCSSCSTILPCFCATSFSMALIRPSGLLHIQKGELHPAIFRRDYDRVAQSTLCVRFLRGETTALGSSFPWEGSFQVTYESWSMTVCSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCK9</accession>
    <name>A0A8G1RCK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_5711</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520623.1">
        <property type="nucleotide sequence ID" value="XM_025665495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCK9"/>
    <dbReference type="GeneID" id="37168897"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH62701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="204" mass="24029" checksum="7335D82C480A5161" modified="2022-01-19" version="1">MVHTFPLLKSLKPSHRFSTLKATTDCTFGRKSGEKEHQKIKMTHSCPNWLRVVLLGLEITVFLPQLWRIRDQKASTGLSLIYIFLNLFSIIECLIIGFFTAINWTITDTNKPCFFVHSLRTVRDCLNLVQLGVDWVLLFFLLSFILYLSYLFLFLLFLHQTDIYFCRCPVHSIYFYFLLFFFLQILSSFLSSMNPVNLNPTLMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCR8</accession>
    <name>A0A8G1RCR8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_410079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520713.1">
        <property type="nucleotide sequence ID" value="XM_025657460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCR8"/>
    <dbReference type="GeneID" id="37160862"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="456" mass="49799" checksum="2210039835611B8C" modified="2022-01-19" version="1">MPPVATPFRASSRRSAGPQFASTPRFFLSQTPASSRPSQEIDSIDQDDFAYATPAPSARNLKREREQVPTPRPKEFIEDLDQPDDDAAPNEGELQSSSPPEPGELDASFDEVFGSIRDRQKRRRVSGHNDADNTPSVQRRRPADRILSSSPDPPAAAAAAAADETTLSVQFQTPKQIRPDPGFRKPERPAETPHPVTPASINPSSLQPRRFVLSASQLPPSSQTQVNTAIPPSTATPVPSSQRRTPAFVLPRSPSPQEDDEPTGIPTPFSPSSRALRRRGRHRSAAHNYVPGGMAAEVRSWILEMGAKREQQQTSPSHYRRTGPPSLDTYAIAIRITCARQSALPSCGALTFAQGHTVDPSETNETDTRFQTQTKNVLLLGPPRQQKSRHAATHIPDLEPGDVVGVFRGLAWEVDLGEPAPALEVGLDLDGLSQSDRSYMQSAGKWHVGMEWELIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD56</accession>
    <name>A0A8G1RD56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_444781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521419.1">
        <property type="nucleotide sequence ID" value="XM_025659108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD56"/>
    <dbReference type="GeneID" id="37162510"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="42"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="149" mass="16601" checksum="ED628F65D2D4173A" modified="2022-01-19" version="1">MPIPSSLLRIYTQLFKPTKTINMPLISNFQLPASVTLLEVPADKKLFLAFVSSADPATGQAWCPDVRAAWPKIEEAFSGDEGPQVGVVEVGQKPEWKDPQNAYRTRWNVNNIPALVRYESVNGEIVETGRLVEGEILDQEKLCDFIGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDI1</accession>
    <name>A0A8G1RDI1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_444524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521133.1">
        <property type="nucleotide sequence ID" value="XM_025659031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDI1"/>
    <dbReference type="GeneID" id="37162433"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034428681" evidence="2">
        <location>
            <begin position="20"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="418" mass="44934" checksum="293C57B2451F5809" modified="2022-01-19" version="1">MYIPSVLLLAASLFHGATALPTPGSSPIPPSQDPWYSAPEGFEEADPGAILRVRPAPGNLTVVVGNASAAYNILYRTTDSQYKPSWAVTTLLVPTEAASAAINQSVLLSYQIAYDSFDVNASPSYAMYTSPPSDIILALQQGWFVNVPDYEGPNASFTAGVQSGHATLDSVRSVLASGFGLNQDAKYALWGYSGGALASEWAAELQMQYAPELNIAGLAVGGLTPNVTSVMNTVTSTISAGLIPAAALGLSSQHPETYEFILSQLKTTGPYNRTGFLAAKDLTLSEAEVFYAFQNIFDYFVNGSATFQAQVVQKALNQDGYMGYHGFPQMPVLAYKAIHDEISPIQDTDRVIKRYCGLGLNILYERNTIGGHSAEQVNGNARAWDWLTSIFEGTYAQQYKTEGCTIRNVTLNTTSSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDL7</accession>
    <name>A0A8G1RDL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hemolysin-III channel protein Izh2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_456430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520412.1">
        <property type="nucleotide sequence ID" value="XM_025661443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDL7"/>
    <dbReference type="GeneID" id="37164845"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH62490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="326" mass="36861" checksum="21D31D1B391E659A" modified="2022-01-19" version="1">MPATFADSPSITETLPRQRKPSPLPPGAIAEEPATPEKVLFDDGTPILVSYDEIPEWYQDNEFIRHGYRPVSNSTHACFASWLYLHNETVNIYSHLVPAVFFLASEGMFYQYLQVKYPEATLSDHAIFAFFLLTAVICLGLSTTYHTLMNHSLQVSELWLRLDFVGIIVLTLGDFVSGIYMVFYCEPLLRRIYWGMIISLSCITIMILVNPKFQGPCWRTFRVCTFVGTGLSGFAPLIHGISIYGFAQMMVQFGMPYYLGEGVLLILGALFYTMRIPESIKPGRFDIFGCSHQIFHVLVVLATVVQLIGILSAFDYNYNHGECRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDS8</accession>
    <name>A0A8G1RDS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sarcosine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_473525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520771.1">
        <property type="nucleotide sequence ID" value="XM_025662628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDS8"/>
    <dbReference type="GeneID" id="37166030"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH62849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="436" mass="48010" checksum="0F67BCAEDE90E7C3" modified="2022-01-19" version="1">MVSTSKSDPIAIIGAGVFGLTTALHLSSNGFTNVSVFERDNQVPARYSAGHDINKIVRAEYEDPWYTELTLQAIEGWKTPLYAPHYHQTGFLHLVSGAAPEKASQTMNRFLASIRNHPTYKGKLTTISTPADIRNIAWQLTGPLPGWNGYFNQLAGYAHSANALRAVYEAAAARGVKFFLGEDIGRVTSLIYSSPTNKKQVTGVRTANGQTYPCKLAVVAIGAAASTLVPEAGGQVVAKSWSLGHVKLTDEETSMLRGIPVTYARDLGFYFEPDPKTNLLKICPMGGGYINTDPASGVSIPPKTLQESEGVLPAEDEKRMRRLLRESLPQFADRPFVEKKLCWFADTSDSEFIIDFVPETEGSVVLCSGDSGHLFKMLPIVGDWVFTLLKERKQGVGRWRWKGGKKKEGKWEGDVSWRLGETREFEEVRLAPAPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1REY2</accession>
    <name>A0A8G1REY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_445486</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519987.1">
        <property type="nucleotide sequence ID" value="XM_025659271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1REY2"/>
    <dbReference type="GeneID" id="37162673"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF600">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G02580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034472596" evidence="2">
        <location>
            <begin position="23"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="72"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="202"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH62065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="354" mass="40038" checksum="59837F5F33EE58D5" modified="2022-01-19" version="1">MPSSRWWLYVQAIIWRFLMRIGMFLHDVTPPRPPRPAFVRTIPTGSGQIRLCFYTPPNYPITRKEGRRLPVVVNFHGGGFTLGCPTDDSRWAQCVLGEVGAVLVSVGYRRAPEHPFPAAVDDGVLALQYLAAHAVELGLDVSRIALSGFSAGGNLAITVPLRLRSILSEQQQQQQQRDQQDALEPRSSPPNLGPYDSTQQLVSAASTSELNIVALFCWYPILDFEESRDHRRAMSLMPSKTLPAFFTDLFDESYLPTREERVSPYASPVHATDEILADALPHDIFFYICEWDMLLKEGQVFVRRLQNINKHVRAMMIEKAPHAWDKSPNPFRDQDSVDILYRDACADMKHIFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RF21</accession>
    <name>A0A8G1RF21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purine and uridine phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_25496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521431.1">
        <property type="nucleotide sequence ID" value="XM_025654966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RF21"/>
    <dbReference type="GeneID" id="37158368"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="12985" checksum="615E52F9FCC88059" modified="2022-01-19" version="1">MNTRSPGYAHYQSNWRLQRPYSIAFSSLRKLEIDSNTYTLGSMSGHNIVIACLPSAVYGTSSATSLVAYMKRTFPPLRFGLIVGVGGGVPFSGADVRPGDVVVGTPIGKQGGVGTKYSPPTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGR6</accession>
    <name>A0A8G1VGR6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_454440</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 13">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509812.1">
        <property type="nucleotide sequence ID" value="XM_025661288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGR6"/>
    <dbReference type="GeneID" id="37164690"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="14">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="11">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH51890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="128" mass="13995" checksum="1A02FF8D2CC610A4" modified="2022-01-19" version="1">MSASPSPSAGGDSKPTDQIHFRFCRECSNLLYPKEDRINNRLMFTCRTCHVGEPATSYCVYQNKLSTQVGDTAGVTQDVGSDPTLPRSNKLCPSCGEADAVFFQSQQRSAETGMKLYYVCCACGNVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VH52</accession>
    <name>A0A8G1VH52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_472348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510891.1">
        <property type="nucleotide sequence ID" value="XM_025662547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VH52"/>
    <dbReference type="SMR" id="A0A8G1VH52"/>
    <dbReference type="GeneID" id="37165949"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="5">
        <location>
            <begin position="16"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="4">
        <location>
            <begin position="92"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH52969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="251" mass="29053" checksum="86E22797BDB4BA01" modified="2022-01-19" version="1">MASTATTVPTKEQVLVPETLLKKRKSQEQARAVAREEAEKKKAANKEKRAVIFKRAESYVKEYRDAEREKIRLARVARKEGNFYVADEPKLVFVIRIKGINKIPPQPRKILQLLRLLQINNGTFVRLTKATQEMLTIINPYIAYGYPNLKSVRELVYKRGYGKVDKQRVPLTDNQIIEENLGKYGIVCMEDLIHEIYTVGPNFKQANNFLWPFKLSNPTGGFHTRKFKHFIEGGDYGNREENINGLIRQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VH89</accession>
    <name>A0A8G1VH89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MCM7</name>
        <name evidence="14" type="ORF">BO85DRAFT_453239</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VH89"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="400"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH53151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="807" mass="90086" checksum="28F23922037ECD1A" modified="2022-01-19" version="1">MALNAYTLNVNYEAQLDAFKDFLKHFKSFESASESAATEAIEDLRIDEDGTSDEYDFMDDVAQEGSAQRAGRRRREPKLKYMQVLQEVADRERTNILIELDDLATYEKGLSDDVDLRLVESVQKNTYHYIDLFSRAVDDLMPKESKEITFKDDVLDVIMSQREKRNEAMNMAAEANADADAAQSIFPPELTRRYTMNFKPLTPSGSSSDRQSKALAVRNVRAEHIGGLITVRGITTRVSDVKPAVEINAYTCDRCGCEVFQPVTTKQFLPMSECVSEECRTNNSKGQLFLSTRASKFVPFQEVKIQEMADQVPVGHIPRTMTIHCHGSLTRQLNPGDVVDIAGIFLPTPYTGFRAIRAGLLTDTYMEAQHITQHKKSYNDTAMDSRTLRKIDQYQKSGNMYEYLSRSIAPEIYGHLDVKKALLLLLIGGVTKEMGDGLHIRGDINICLMGDPGVAKSQLLKYIAKVAPRGVYTTGRGSSGVGLTAAVMRDPVTDEMVLEGGALVLADNGICCIDEFDKMDDSDRTAIHEVMEQQTISISKAGITTTLNARTSILAAANPLYGRYNPRVSPVENINLPAALLSRFDVMFLILDTPSREADEELASHVTYVHMHNKHPEHEDAGVMFTPQEVRQYIARARTYRPVVPSAVSDYMVGAYVRMRKQQKKDEAEKKQFSHVTPRTLLGVVRLSQALARLRFSNEVVTEDVDEALRLVEVSKASLANDGQSSLDQSPTSKIYYLIRSMMESGAAAVGDGDGSELSMRRIRERVLAKGFTEDQLNVTIDEYEQNNVWQVLGGGTRLVFVDAMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHT1</accession>
    <name>A0A8G1VHT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_405297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511656.1">
        <property type="nucleotide sequence ID" value="XM_025657295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHT1"/>
    <dbReference type="GeneID" id="37160697"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="65"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="450" mass="50658" checksum="4A3736647E52B26F" modified="2022-01-19" version="1">MASSDASIVPFGATMREQFLFDPKFLNLNHGSFGTYPAAVRTALHHFQDQVEARPDPFIRYTTPKELDVSREAVAKLLNVPRNECVFVKNATTGVNTVLHNLPFKSDDVIIYFETVYGALEKGIVSFIESRAAQIRKVRYEMPISHEDLVERFLQVVREARSEGLNVKLALFDVVTSLPAVRFPFEKLTEVCREEGILSLIDGAHGIGQLPLDLAALQPDFFTSNCHKWLFVPRSCCVLYVPKRNQHLIRTTIPTSWGFIPSEDSPATAPSVMKSDDSSKSAFESLFEFVATNDDTPYFCVPAALEFRKTVCGGEARIYEYLERLVNEAADIVAATLGTDVMEERALQPGKQSNLRRCAMATIRLPFTFREDLAASDSSATLLKADEAVAAVRWFQTTLVEEHGTFVPLVEHGGWLWVRISAQVYLERKDFKWLAEVLKVLCQRYRTRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIG8</accession>
    <name>A0A8G1VIG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_160801</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511164.1">
        <property type="nucleotide sequence ID" value="XM_025654232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIG8"/>
    <dbReference type="GeneID" id="37157634"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000072">
        <property type="entry name" value="Cyclin Pch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000201">
        <property type="entry name" value="Cyclin pch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="Cyclin-like" evidence="8">
        <location>
            <begin position="60"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="283"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH53242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="552" mass="61134" checksum="A74DFD05E1084DBF" modified="2022-01-19" version="1">MASSAAHPSELPPVPAPSNPVLLATQAHWIFTDEELTRTPSQLDGMALEAEHMSRSKGVNFINQVGIMLKLPQLTLATAAVYLHRFYMRHSMVDLPQRPGIHPYTTAAAALFLATKVEENVRRMKELVVACCRVGQKQPNMVVDEQSKEFWRWRDTILVHEDVLLEALCFDLQLEQPYRILYDFICFFRMQDNKPLRNVAWAFVNDSGYTVLCLQFTARIIAAAALYAAAQHCDIGFEDDVLGRPWWEQLEVDLTQVRRACMRMAKLYENNAAHRNGLYYLTNPISTDEGTEKTRIPRVDGPADNTTRPIDSGHEADTVNGRKRSRDPDDETKPPRPLADSIPLLEAGPATQNGAPSPKRPRRDSVGASADRVPSSRIPKAPLPSGGPAFSHDRPSANGHPPPAHHSHPIPATRHTHPLPPPPRPYPRRDSGSRPGGGPPGPPVDPIQQRIDEIVQQNMSTQGGGPGRAERRPQERHRGDWEAETDSGRRRRPSMSTGGQLPSQEDAHPHPPPQHLPPPPPPEEESCPPSQPEPPQAPEPEDEGGGSEEGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VII0</accession>
    <name>A0A8G1VII0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BO85DRAFT_103198</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512303.1">
        <property type="nucleotide sequence ID" value="XM_025653792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VII0"/>
    <dbReference type="GeneID" id="37157194"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000039">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="841"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="888"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="919"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="23">
        <location>
            <begin position="44"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="24">
        <location>
            <begin position="740"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RAH54381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="968" mass="106866" checksum="F91F2CA0F8C3D8E5" modified="2022-01-19" version="1">MAVSFGIQSWIEGGVICAVIVLNIVVGFFQEYAAEKTMESLHSLSSPTGTVSRGGQTFSIPSQEIVPGDMVELRTGDTVPADIRLVEAVNFETDEALLTGESLPVQKECDSTFKEDTGPGDRLNIAYSSSTVTRGRARGVVIGTGMSTEIGSIALALRNSNTKRRPVKRGPHGETKKRWYLEAWTLTGTDAVGRFLGVNIGTPLQRKLSKLACLLFGVAVVFAIVCMAANYFSSNNEVIMYAVATGISMIPACLVVVLTITMAVGTKRMVERNVIVRKLDSLEALGAVTDICSDKTGTLTQGKMVVKKAWIPSRGTYSVGASNEPFNPTIGDLSFAPVSPLQFGEEDEGLPGANIEDLVSDNRQLQDFLNVAAMANLSHVFESENGEWNARGEPTEIAIQVFASRFNWNRDRWTKGQGALWHQKAEFPFDSTVKKMSVIFSKVGSKDDQDNATMVFTKGAVERIVDSCTSVIWDQGSSTPVPLTNEHRNLIFQNMEELAKLGLRVLALAQRPYTEQARVLEGSDLERDSIEKDLCFLGLIGLYDPPRPETAGSIQACYRAGIVVHMVTGDHPGTAKAIAQQVGILPSDFSTVAADVADAMVMTAGQFDKLSDEQIDGLPTLPLVIARCAPQTKVRMISALHRRNRFAAMTGDGVNDSPSLKHADVGIAMGQAGSDVAKDASDIILTDDNFASILNAVEEGRRIFDNIQKFVLHLLAENIAQACTLLIGLAFKDADNQSVFPLAPVEILWVIMITSGMPDMGLGMEVAAPDIMDRPPQSKQGIFTWEVIIDILVYGIWTAALCLAAFSVRMWGFGDGNLARGCNQEWSDQIQDCELVFKARATTFVCLTWFALFLAWEMIDMRRSFFRMQPESKRYFTQWMYDVWRNKFLFWSIMAGWITMFPILYIPRLNDVVFKHKPITWEWGIVGVEAVLFFLGVESWKWAKRVFFRRRDRKNLQLASMGNMPEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIU0</accession>
    <name>A0A8G1VIU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhomboid family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_454279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509980.1">
        <property type="nucleotide sequence ID" value="XM_025661246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIU0"/>
    <dbReference type="GeneID" id="37164648"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21690" checksum="9B5B18455F1722EF" modified="2022-01-19" version="1">MTTPPPTDDLQSRREADYERFKTAAAYTFLIASPVLIALPPRKLDNLTVLLTSAFCVSANHLTREHTGRSIVDRIEARISRNPITALSDLPSQRAQEIQAKLKAARDAQIREGSAVGEELERLKARQAQEKPALEKIWMGGETEGWKERRIREEQKALEEGKGYGDLIKEHIWDVWNWGQKGDEKETKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ24</accession>
    <name>A0A8G1VJ24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_402773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512888.1">
        <property type="nucleotide sequence ID" value="XM_025657204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ24"/>
    <dbReference type="GeneID" id="37160606"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="688" mass="78198" checksum="CF1BF1E943D641C5" modified="2022-01-19" version="1">MSLRWRKKTHWPPSPCVEDEAVSLSRELHGLSQIGEMPGLEGVCSRGTVDQYPVLVDVFSYSSYEETTVIYEDFSRDSSSEDNVGPPTPVDEKQGPMLYLVGDDQAVSLSAPLASREKPQDPSKKPAVQRQDSTTRGRPRADTRAQRDSPPKRDTAQSSRDASRASNIRTPAVTQSKSTPSLPRRFGSVKHGRSADALTTKSGYQSDSATVKSKTKPEPVNKPAAPQTDKKSPTGLSVAERLEEKIRQRQELRAKGGSSDVPKTPSPPSTDQPSVPVELPAEPSTTPAVTAAPKSTAPKTRPRSTSSSLPRTPEDIPEPPPLPRRRSSSQDAVRHRSSSQDAVRQTSPKRPFFLPPCPRSTPIAGYQDWHTVKGLPHLNICPSCMKQMRKSEFRDHFVLASPRSRGEKIRCSMSEPWTRLAWMQTLKKQLDHLELLHQITRPPLSIKPCPGRIITEQHWYRIVDPETNMYLPQFNVCSACVRNLRVLMPQHRDTFKRSSTKQERACDFLTDSPRFVRYIDCLDIAANRADQEHMLRPDVTEFLSYARRKVVLRDCRRDRRILSTWHYMPQLPELTVCEDCYDDVVWPLVRAKHPIARKFSTSMRLLPGDGPSRCREASCQLYSPRMRAKFAEAVQSNDLMYLKQVALRRRDAEQRYRDREEELLEDASRGYDVEGEMRRNVEEWKRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJG9</accession>
    <name>A0A8G1VJG9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="4 8">3.2.1.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_462469</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Endohydrolysis of (1-&gt;5)-alpha-arabinofuranosidic linkages in (1-&gt;5)-arabinans.</text>
            <dbReference type="EC" id="3.2.1.99"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="4 8"/>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512199.1">
        <property type="nucleotide sequence ID" value="XM_025661852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJG9"/>
    <dbReference type="GeneID" id="37165254"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18831">
        <property type="entry name" value="GH43_AnAbnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF5">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034916301" description="Arabinan endo-1,5-alpha-L-arabinosidase" evidence="11">
        <location>
            <begin position="24"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="10">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR026534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH54277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="371" mass="40434" checksum="3F1F6B7CA76B59E3" modified="2022-01-19" version="1">MKSITMLQSVISVLFFLLYAVNAVPLAPRASALAGIDTKSFSKTNDYPLPNLGNIVAHDPNVVQHDGYFYLYKGGVHIPIHRARSLSGPWEQVGTVLDESSVIQKQNRSRPWAPTTIQHDNRFYCFYAISENGSRDSAIGVASSDTPTGGNWTDHGAVVNTGNGDLSDIYPYSVSNAIDGAFITDQETGQSHLLYGSYWHGIFSVPLADDLLSVKTPKTPNATNLAYIPDAKSKPIEGSFMTYKEPYYYLWFSHGKCCHFDIHAFPPMGDEYSIRVGRSKSATGPFVDKDGHDTLKGGGTIVYGSNHGVVYAPGGVGVLINNGSDADVLYYHYLNTTSGFAQGDAHLGWNYLHYVNGWPVAVEGYVNANGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJL1</accession>
    <name>A0A8G1VJL1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_489742</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513666.1">
        <property type="nucleotide sequence ID" value="XM_025663623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJL1"/>
    <dbReference type="GeneID" id="37167025"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:tRNA queuosine(34) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="entry name" value="QueA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="entry name" value="QueA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="S-ADENOSYLMETHIONINE:TRNA RIBOSYLTRANSFERASE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE:TRNA RIBOSYLTRANSFERASE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="QueA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH55744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="356" mass="40719" checksum="6087918BB2D2FB05" modified="2022-01-19" version="1">MKTTEFEFDLDYKVMPHDPVELRGKTRDSGKMIVLDRESSKIDHAIFSSIGDYFRPGDLLVLNDSYMLSNTLWFEYGKNETLQLTVYGHEPDGTTIVELKKPEVTFNRGQTLISLDEEKLKCTLLDQQPDKLWKVQFSPADLLLPTLDQYGARLDENIHLNPTYWKEKPDAYRSVYAKKPGSLEIPSAGLHFSHELLAEISAKGVEIAYITLHVGATEILSVRHISVEEIEKHKVRSEYYEVSERTSAQLNRARGEGRRVIAVGTTVMRTLETITRETGRKGTIKPQHGWTDLYIYPGFEFNAVDVLLTNLHRPRSSHIVLTAAFAGTEFVMRSYKEIQEKGDYEFDMFGDCMLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJW1</accession>
    <name>A0A8G1VJW1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_505306</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511060.1">
        <property type="nucleotide sequence ID" value="XM_025664330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJW1"/>
    <dbReference type="GeneID" id="37167732"/>
    <dbReference type="Proteomes" id="UP000249526">
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034524696" evidence="7">
        <location>
            <begin position="20"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH53138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="333" mass="37812" checksum="5D11648BED664375" modified="2022-01-19" version="1">MGRTLVLPFSLIILALTWASFIPQIKHVWQTKDSRGISTAYLLFNLLCITEHVFFQSLDTACLWDISKLPSSPFSVYPLDWANLAQVLGDWVLSNVLFLLCLYYSPPTRPHRHRLRILLILALYSFFLLFTLIPLVLDLTTDVFCPPSNPHDCPLPERDVVPFLHGIHCFFLLPITTVILPVLGQPSRQHQQGPREQAIMIPPSHPPSPTKPTDLNRLLSRSRLFQASIFALSAILWIFRLPPGQQERAYDPPPPPDDPLPPQPWLFVFLHWWMSMGYMTVDEVIFAVGQGVLGYLGLRKAIAAEGRSEGEEEAERRLLLVAAEERSTYGSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJX7</accession>
    <name>A0A8G1VJX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_463163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511105.1">
        <property type="nucleotide sequence ID" value="XM_025661903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJX7"/>
    <dbReference type="GeneID" id="37165305"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="152" mass="17105" checksum="A094FC3AE44BEA8C" modified="2022-01-19" version="1">MVQSQWISFRLVVNHHWSKMPAHPPGGCLPVGQLAPLFRGHFFSRNRRRLMVASAALTGCARLLQHSREQTATRQWTTASRRGSHWKSVSSGPILVYCRYRIQGCSTLVHAVAPKTHSSLSPQPASQTEYQPGGFPLIGRQSEIKTIYRQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJZ8</accession>
    <name>A0A8G1VJZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">K+ channel tetramerization domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_452231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512709.1">
        <property type="nucleotide sequence ID" value="XM_025660771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJZ8"/>
    <dbReference type="GeneID" id="37164173"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="2">
        <location>
            <begin position="31"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH54787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="454" mass="51516" checksum="ACE9B88A56D0E92D" modified="2022-01-19" version="1">MSSDVGRPTLSQTPSNGEPKCTLPLEKVFSIQIGTELFRLSGASIASDAPSYFSRFFEEQLRLNGDISNVRTLYIDRDPTTFKEIARHLQGYHIQPKDGPQFVKFFADAQFYSLPRLISQLFESEIFVRIGGHNFQIPRDIFSSPGDSPNFFTLGFAAFFASPLEVFPGLDRQGLLRPPAITPPSVPSRSGEVFAQLLHLLRGYPLEIRNEAHRAELLRDCRYFHLRGLEQQLIPHHISFNPIRKRDEIVIRLEDVRRSGIDVDDIALPPGHTQADTMSAALVTYSRPFVDDKKYDLILEIGDESTILDITSRRPTFLGTTKARVSSLLQVIAGKKGDQNRPAGQKESAPEDRLWASLSMDTDMTVDGEREYFPDILRDSMSGSESLSEEPSRKRKRVEEASINRPWIVRNGQWRLCMQPRAKGDGMDIVMIAVKLEVYTLQRTRNKQRKFLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKB7</accession>
    <name>A0A8G1VKB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_451308</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-W/WIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513442.1">
        <property type="nucleotide sequence ID" value="XM_025660560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKB7"/>
    <dbReference type="GeneID" id="37163962"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13732">
        <property type="entry name" value="HFD_CENP-W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000075">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052484">
        <property type="entry name" value="CENP-W/WIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="9">
        <location>
            <begin position="9"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH55520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="78" mass="9028" checksum="B2DF1B619D6F01CA" modified="2022-01-19" version="1">MAATQKLYPRATVKRVVKAHSNRNVSKNADILIFLDYMLFMQELMRESSIQSRKAGEKNISPNSVRKVTERTLRKFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKX9</accession>
    <name>A0A8G1VKX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_479101</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514087.1">
        <property type="nucleotide sequence ID" value="XM_025662931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKX9"/>
    <dbReference type="SMR" id="A0A8G1VKX9"/>
    <dbReference type="GeneID" id="37166333"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000173">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="137" mass="15337" checksum="FEE2B636D9BEE4DF" modified="2022-01-19" version="1">MPLQGIRTVTAARNGVGAFILQCKRLDFHYCDWAGSSRGMVAYLKHHLPAFAKANPQIEIRVSPRPHKHPVIKGHYINGREKAVCVRNLEPEQIGKKADLLKQASGEKLKRTKKPVTSINESVRGIWSPYHGGYKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLI8</accession>
    <name>A0A8G1VLI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TOM complex component Tom7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_448963</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515781.1">
        <property type="nucleotide sequence ID" value="XM_025660060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLI8"/>
    <dbReference type="GeneID" id="37163462"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944:SF2">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH57859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="53" mass="6097" checksum="BA6AFE5CB17CFC39" modified="2022-01-19" version="1">MVQFSEETKERISKVIDASRVAIHYGYLPLIVYLGYTYSEPKPSLFKLFSPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLK0</accession>
    <name>A0A8G1VLK0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_288621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515811.1">
        <property type="nucleotide sequence ID" value="XM_025655242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLK0"/>
    <dbReference type="GeneID" id="37158644"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF3">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33174" checksum="E333810B60A3023E" modified="2022-01-19" version="1">MDAPQVQVGAPETSSNVGNESESTYPTQKTGDRDVDVTAPSSGVNERQADSTEDIDLPDAGAAEPETAPALPKKNPGFQFLDFLKSPIVELVVGTGESKTSLSAHQSLLLESPILAEKVTALGESSARRIELPEENVEAFGYFLQFQYTRDYSASQLETPTEQEAVSGEIDDSGEQLLKHARVYTLADKLGIPALKTLAHSKIHRINSTSHGEIAYARYVYMNTPVDDVTIRKPVATFWALRSHILRHEAEEEFRKLCVEVPQFSFDVLSLVLDQKEKRAQDKAESESAVKGSGRKRLRSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM63</accession>
    <name>A0A8G1VM63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_470672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513310.1">
        <property type="nucleotide sequence ID" value="XM_025662417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VM63"/>
    <dbReference type="GeneID" id="37165819"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="256"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH55388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="609" mass="68735" checksum="018F17783BBC8D15" modified="2022-01-19" version="1">MRVLEGNSAITSPPENHRAADRSTSLIESSNEYLGPTSFTSVFIEHGDCFELEDANKTSGIRRDPAPDPQVDTPLVQLGARILSHIPEERNCSMLFSSHINPNDGWVRLAGHHSSDRMWNAFRPALRRRSEEDMLETAAILTRNSKIPLQKKQDPHSWLASFTGTQMRWETLGILYTYWACGAISSSSESQAVAEYCQAHSSVTNAKQLMTHFKRCASLCIDLCKQLGSINLLFVYLLYKHNILEGILSGDKSFSHWTQHGELVAVTTSLGLHRELATEAETVSLPYELKRRLYAAVFNIDKVISTFTGRPPLLSRAYSSTRLPLDLSDDALLSSDLPSAAAQLDSCGWNRNNQIYSTTILRSRTSFARIRHEVLEVLESSMDDLADGSVNKAINLKQRSHDTYVQLPSVIQFSKSELSNTNVSGYVLYAQILTRLEYLLNLFLLERLLKRHNIVTGQDLVEVSHEMLDLTLIFWRKKDRYVGLYADFEWLTMSYAIPASGILCLELLRQATHPQSCQIRLPRSPSIQNLSLLVVCLDWIETEASSKSIVRSIRRILSRSLDRILDPDPPGVEQLQSVAPFLDDELPQYPHLQLLNTFDWVDWDGGIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMA7</accession>
    <name>A0A8G1VMA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SH3 and Ded_cyto domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_448669</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516576.1">
        <property type="nucleotide sequence ID" value="XM_025659995.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37163397"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="6">
        <location>
            <begin position="450"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="7">
        <location>
            <begin position="1274"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1671"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1690"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1716"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1747"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1816"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1839"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1852"/>
            <end position="1862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1944" mass="217573" checksum="FF5505AB57A6CFF5" modified="2022-01-19" version="1">MPLAPINVAPRDPDAPKPAAPVPMLKIGDETPTSLSEPLVDEIASCLREWHSTNLHQLLLSRQYVTVEEMTKIVEELDFARRQLLYNVLTAQEKDALRQEVVWKLVRGNKALGGEIIVRDPQQRGRLLTGEDSAVELARLQSEMSMLDSSPMQQSDAAALHHLMLEVNAVSGHAPGPVTLAVYLCSQSETGALTPLSETYILDIPSPEKFASMGQSAKLKTLFTDLSSTDIGDSAANGPRLYMVVMVRAPEIASVVSAAAQPRTSISRDSSPGTKQQNGINQSVKGSLRTRRSMMWTSKPRGITSPEQGKEPSKAPPPSSGSNTSAKEKSSSQPVKESTQLRTVGVGFLEVSQILRQEKDAEQVINIWSPSEDGEDKEGRDDGFDGVVRTLLPSPTGKYVRSQRAARLHFHLYPYVDPDADSLVRKNPTSLHNVVQTRRMGFSQAPTKPRSDIYVTISHATFPPEALLSHPQSGQVPVPGHTGLRNLQLTLEVRTSSGARVDRCVLPASNHAAQTAWRTTVADRGAPWNQTIRLNIPTDQIPGSHLIMSIADAPEFPFALAWMPLWDNQAFMRDGPHSLLLHAYDKYTSHIENGKGAYLSLPWSSLGKNESAKDEAITGPLATLRLDTHLCSTEYSQDQVILSLLNWRERPVNEVLDTLKRVLFVPEIEIVKQLSSVLDSLFGILVENAGNEEYEDLIFNDLVTVLGIVHDRRFNLGPLVDHYADNQFNFPFATPCLVRSYLRLLQASSDAQQSRNLRATFKVGRHVLKFIINARLQQKEKEEGIGITRVQSTFNRDLHTIFKSLEALMKNLSPAMVGNKTLVVQHFHTWLPELSKVLSRDEAIMIALSFIDSCKDVTGMLILYKLVLIQHYTRLEIFGSGSERKSLVSSCISWLAPYWGATGSVSDLYRDQVRLCCAIVAELLKQPDPYLYEFVPKIVSSYYSIIPDGVEETTYLSLLFSKSFPFQVKSSKHSQKFDEALVELSAVLAGAATIPNPKRPRLKGLELSSFLTQAFEVHTSILNCEAYPESWFSVHVYNHRATVKSLEYLATILTNKFLPSPDDAETFDTRLWETFFMTLLKVVSSDALALETYPEQKRRAIWKIAGDVREQGADLLHSSWESIGWETTDEEKEQYGLSRLGGYQVQYVPGLVAPIIELCLSVHEGLRHVAVDILRTMILSEWSLNQDLSIIETEVISSLDNLFKRKNMSESVVQKLFIAELSDHFESSADYDEDLSNAVKALIATVDELLDLFVASQGGSMAESLHTLRLMKYMKDMGREDIFIRYVHELAQVQAAAGNFTEAGLALQFHADLYDWDPKRMLPELLNPPFPEQTSFERKEALYFAVIQHFEDAKAWAHALVCYKELAQQYEDIVVDFAKLSRAHGSMAKIYDLISKESKQFPRYFRVQYKGLGFPTTLRDKQFIIECAPTERMVSFIDRMQREHPAAQVVSSGEVHDYEGQYLHINPVSVHRDVDHPVYQRSKIPQSVRDHLLVSEPCHFSSTLRKHVRDVDVKEQWVEKTVYTTAEPFPNILRRSEVVEVKEVALSPLHTALERTWRKTHELSMLQRRAASGEDTGFNNLSEALEQLLDLHAATPNCVAAYRPFLSDAHEEEEGGLVTPKPVDPMKNALAVALIDHALAIKQALALYHRPAHQATQAELTRRFEEAFGPEISSLRPAEIEQTPQWPRRSTPESIKERQKPPASRALSPEQELIRSSRKNHSRKHSAKQSVSHRISVMNPFKRGNHAASNSVSTVQEDPKPQSDTKANGTATEEHVNGEVDQDDAATIHSRTTTQSRDTHHKRRSRLGDVLHKHTSSLSISASATEESQSQKKQRTRSASRDTAGKSHDSVSRTTSHTNGTSADDRPSVSSHKGGWSTIPSITDYPRPVTRSSVNSVRSPELMSPVSQSGGMRDSVFKRFSLLKGVSRKGSRLDFRTETPVREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMA8</accession>
    <name>A0A8G1VMA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 alkane hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_438692</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515512.1">
        <property type="nucleotide sequence ID" value="XM_025658685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMA8"/>
    <dbReference type="GeneID" id="37162087"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH57590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="483" mass="54867" checksum="666B11753615F3B5" modified="2022-01-19" version="1">MIRRLTEISPALDNVYAYVMANSRCEDLTYWQNLMETAHGASTIDHVQTAELDIGISNRVIITKDPENIRALLTGQFADYGKGEPFHHDWKEFLGDSIFVTDGELWSRSRQLIRPMFTRDRIVDTELFEHHVQHLLPLLAGTKSNKVVDLTPLFLRYTLDAATAYLFGEGTNSLQNPATSFADAFSYVQHRQGEIFRYGPFNPILSRTKFRQKLKIMNDFMAPFIQRALSLSPEELDKSLSKQETFIHALARFTRDPQVIRDQLTAILLAGRDTTATTLAFCFFELSRNPSVVKALRSEIASRLGLGPSGRKPTYTDLKEMKYLTAVLNETMRVYPVVPFNVRYALKNTTLPRGGGVDGTGPVGVRADTRVIYSTMMMQRDPAHYPSPGSNKNYFDPGKWIPERWMGDWVPKPWYFVPFNGGPRICLGQQFAMIEMGYTVVRILQAYESLTAVPPAGKDKVEDPMLRFEITLNPGCEFNCVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VME5</accession>
    <name>A0A8G1VME5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="4">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_479585</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="4"/>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513535.1">
        <property type="nucleotide sequence ID" value="XM_025662958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VME5"/>
    <dbReference type="GeneID" id="37166360"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000017">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8 16" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="17">
        <location>
            <begin position="210"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="238"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH55613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="539" mass="59795" checksum="598F10EEA5D4BCBD" modified="2022-01-19" version="1">MADQEVPHATFDTILILDFGSQYTHLLTRRLREINVYSEMLPCTQKIADLPFKPKGIILSGGPYSVYEDGAPHADPAVFDLGVPILGICYGLQEIAYRLGKDNVDAGTEREYGHADLHAKRLDDQGHVDKLFAGLEGQIKVWMSHGDKLVKLPTDFHTIATTSNSPYAGIAHQTKPLYGVQFHPEVTHTPLGATILKNFAVDICGAQQNWTMSRFVDQEIARIRKLVGETDHVLGAVSGGVDSTVAAKLMKEAIGDRFHAVLVNNGCMRLNECDIVEETLNKHLGINLTVVDASKRFLDGLKGVTEPEKKRKFIGNTFIDVFEEEAQKIEAEAEHQGAKIKWFLQGTLYPDVIESISFKGPSATIKTHHNVGGLPQRMIDGQGMRLIEPLRELFKDEVRALGRQLGIAHELVMRHPFPGPGIAIRVLGEVTPERVEIARRADHIFISMIREAGLYDQIAQAYAALDPSKAVGVMGDKRVYAEIIILRAVETTDFMTARAFPFDNEFLSRCSTRIINEVHGVSRVLYDISSKPPATIEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMI7</accession>
    <name>A0A8G1VMI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_519706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515722.1">
        <property type="nucleotide sequence ID" value="XM_025665073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMI7"/>
    <dbReference type="GeneID" id="37168475"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="496" mass="56131" checksum="79F753EBE4A3C836" modified="2022-01-19" version="1">MELINNGTDYTIEDCQMALKTAFFEREYDRTLGKTAQLLDEERRRILHVDQLLLRFDNETLQLQLNQFKQDLLRARNAESDIRNWLQDAVRERDQLQSSAHTATHEIESLRRELASMNSTTAESRNLVTEKLRLTKELANMQSEVHRLQLQENSFQALVTEKQELARQLNTLKVEFENEKRAHRSTMAQGAQQADEISVLTAKLEEQRKQIAAEARKVPATQQPNNMWQSEKAALEDKVESLNRKLRTLKDELRQAQTSNQTSRFETSNSNGPLEQTRKVPLKDFSSRFDPGLDIATPGAVRVKEGKRQPTAVPGQKSAFSITPFLNRTNGNQETSGDTPDNRAGADRLGSDDESALETSYLEDKLHVKESEAEPRERRPIQPKQRLDKSKPAMNSRKASGLRLDDIDDDSDIGSISTLVAGQPQVRTKRRKLGAQSKTILDEEEELEPENIRKPGRKIGLSTGHTSSLQTAQSGPPRGFGGFGGFSPLKKERKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNW8</accession>
    <name>A0A8G1VNW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NCS1 allantoate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_458405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517162.1">
        <property type="nucleotide sequence ID" value="XM_025661583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNW8"/>
    <dbReference type="GeneID" id="37164985"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH59240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="71288" checksum="0EE948407C162015" modified="2022-01-19" version="1">MLYGMNRDASWQPEGNGSERGKLASPLAPFLALSQLRARPSTQQHPIYCRLSQCLTSGGRPLTLRDTITTYQTKMASSRAPRYSCLIEAGQIRSLCDRIPYIDLPYCFFAPAPLRPQLRVPQSRSAFADGSARWTNLDLDPVPFHRRQWGPLSFISYWVSDAFNAATWQFASSIIAVGLSWRESLIIVAISFFIMSFVIAGNGAVGAIYHIPFPVISRASWGFWGSYVAIVSRVILALFWFAIQNVNGGNAVRAMIGAIWPSFLRVKNEIPEDQGITTNGMVGYFIFWLFQLPFLCIHPNKVRWLFVVKSVVVPIAWIAILIWAFVAEGGGAMFEQKATVSGSQYSWVFLASMTSVLGNYATLSVNQSDFSRYSRVTAKWQLLYVPMLPIVFTFISFIGIAASSAGYARYGGSVPWDPIELISHWSSRACRFFAAFSFALASLGVNISANSISAANDLMALFPGHVNLRRGQIICGILSWALVPWKILESADSFLNFMSAYAIFLGPIAAIMLWDFWLLKHGKYDTLALYQPNNPVYRYSKWGVNWRAIVAFIVGVVPSLPGLINSVNSSISVGVGIHPYQFGWLLGFVGTSVVYVGLSWVFPARHAIIDRAVMAEEIYDGREVDGESEEKLDNMDEKAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP49</accession>
    <name>A0A8G1VP49_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_486869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517194.1">
        <property type="nucleotide sequence ID" value="XM_025663414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP49"/>
    <dbReference type="GeneID" id="37166816"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="52372" checksum="44FF08247579C32F" modified="2022-01-19" version="1">MADHAYVEHLTPLDLPMPRTYIRVLFVFPTAISTPKTTQELQRGLENISNQVPWVAGHVFHTTSTNGKASLEIRYHADKIPILEDKGQITASYSNLSSQDMPMKAIPSDVWPTLPDLFGNIPSETGDPVLAASVFRFADHGAGLCICLHHTAVDVTGFAEVVRLWARNVIQPDQTDSSCLPQGSGGRLMRLSEALAPDLQEISSLSSDRLLALHPEHSTQPPVLPDTFPPCMSKPFKVPLHWINVLKELLQKYTRRRLTTNVILCALIWTSVTRVRAQRNPALKVQTSRLVTAVNCRSRITGNLKSVPGDQQYLGNVVLYAMASFPAANLATADEDPIRSLATICDCISNSQSSSTINSRHIAETYRLVDSMEDYRSLYAGWDLFGSRDFTITSWADLDLHNLDFGPLLGKPEFVRLPYMEADGVAIILPRRRSGPDEILQVMVMLRCDDMESLEGDGMWQTLVGSSRSFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP83</accession>
    <name>A0A8G1VP83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_448288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517299.1">
        <property type="nucleotide sequence ID" value="XM_025659901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP83"/>
    <dbReference type="GeneID" id="37163303"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="371" mass="42863" checksum="42A4F0DDF673117E" modified="2022-01-19" version="1">MSTNGPSSTNPPPLNVDETMRQAVDRFRARMAAANRQFIQDRIDEIDARGLATEKERIRMIQRWRHFEDLDQDEPASDNDPDARHISNRFRQTRELAAVPALLAEDTHPLFALDGIHPPLLCTPEARQIFLDTLQEVFQRQAEEWAAAEGEDLASEPIPRCEELGRLLAYAHEVKDPDFRHSGIAPLEAGLFVQQRYGTLPCLDTQEERDQYHACVRQECVWLRERLEGEYTDLINKVQIPASPDVDLDVRAGVVMGTGYVGEYPKWYSAYLYCRKSPDEDMEGIHYQDEGVQDAPNIREWGWRVVFMEEEGILQPQVLYGRKPRFDSIPEFLDWYASWPDYLDARGLLSLRRHLKGCETDCESDCEMHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPR1</accession>
    <name>A0A8G1VPR1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Suppressor/enhancer of lin-12 protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_446234</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518993.1">
        <property type="nucleotide sequence ID" value="XM_025659459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPR1"/>
    <dbReference type="GeneID" id="37162861"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034872864" evidence="9">
        <location>
            <begin position="22"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH61071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="203" mass="23501" checksum="2EDA1392C82077EB" modified="2022-01-19" version="1">MRFSATTLLITALAWFTTVTAHNIQLRAHSRECFHESLHKDDKMTVSFQVGDREFGGSGNLEIDFWVEDPLGNRQYYKHAISSEDYSFNAHSDGKYVYCFSNEGWASNSKEVSFNVHGIVYVPESELAQDPLEAEVRKLSEALAQVKDEQSYIVVRERVHRNTAESTNARVKWWSIFQLAVLIGEGIFQVWWLKRFFEVKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ65</accession>
    <name>A0A8G1VQ65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_483552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519443.1">
        <property type="nucleotide sequence ID" value="XM_025663166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ65"/>
    <dbReference type="GeneID" id="37166568"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF5">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="138"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="528" mass="59452" checksum="4CC0F53D5F7DC31A" modified="2022-01-19" version="1">MKGDGIGWETAPTMLPPPRTSINLPYAHYALIYLDHMGRLRVSESPSIRDNHATIFTSEVRENFLEILGARVGYQKPLLQSINPAALSYDRSDDAPCHRHGKRRRLHVESPVPVTQNPRSEFPSSPSGAAVNRIALEVGDTDRLEQYYTISLRHFQQVNCRVVAKAFIKFIEPRKQVRHPYNGGRPKPGAPPGTKGDPEKTKPEWWPAGVVHREPDHLKKEERVDLLVHIVRKLGRIGVTADKLLEIAFDCRRQLKEQEKFTIIEEIFKVRRMEERYERGEIDASTLVYVMDREAHPKGDKDADSVAGPEAKTEPEEPAEAEEEVTTPTPSVEEIEATFIKEPSDLPVPQTMPLREGKEPIFPLPGSYNFGEPARQDQTFFTSSGDYSGNYSNAIIEDPANQGLITPIEEAASFEYLTQAPFPDASTAEHHAAAAVPMQHSVSQYDHWAPSFREELYSPLEYGAAAGHGLPEPRMHYPLGYATHPEEIHGMPDFTRDQHGYMEPMSSRGPLFRTGSLSHPHFTHSHQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQS2</accession>
    <name>A0A8G1VQS2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_446334</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519082.1">
        <property type="nucleotide sequence ID" value="XM_025659480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQS2"/>
    <dbReference type="GeneID" id="37162882"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF228">
        <property type="entry name" value="P450 MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034067628" evidence="9">
        <location>
            <begin position="22"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH61160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="490" mass="55433" checksum="84B64FCF5961E7B0" modified="2022-01-19" version="1">MLSVLLIAILPIIYLIHEYFTDPLSRIPNAHPLCPYTTKWITHHRNRTTEVKAIYTAHRARGPIIRLSPTELSINSLEGLRAIYTQGAFEKHAFYADTFINFHTPNMVGMLENKAHGEQKRLLSGIYAKSYLLRSGDIKILGREMVVRRLGEFLKGVVAKGAVFNVLPVFQAVGMDFTSGFVFGAQGGTRFLEDLASWGVWLGQYEAFKSLSREDRFMGFVERWCLGLCEGVGLLKEDGGLVTQPVVYDRLWEGLEEKKKVSGEDINLKLAVASEILDHLVAGHETTGITITYIMWELSKRPDLQTRLREELATLSGSLRHTEEMEKKLPPLADIDALPLLDAIVRETLRRHAPAPAPLSRVTPPEGAWIHGYYIPGGVQVSSSAYSLHRIEEVFPSPEEWIPMRWMDAKDDKIHDMRRLFYPFGTGGRMCLGNNFAFLEIKLVIAMVYANYLPEVVDDEDIEQHLEFIALPKGRKLMVRFVPIKGNNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRC6</accession>
    <name>A0A8G1VRC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_444120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520703.1">
        <property type="nucleotide sequence ID" value="XM_025658944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRC6"/>
    <dbReference type="GeneID" id="37162346"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="192" mass="21362" checksum="2013A17F486AF08D" modified="2022-01-19" version="1">MSKLGRSPAGANKRNFYLPLTAVYGMWCKKLIGEGVTPYVFQCTWNEEGDFFLGASRGAYSLHSERPWLAVVDRARFGVIKSEPLTLAGWSLARSPCMECRKKKDGTPFGRCAETYPFCKLLKTCGKGQAEKVYGLALSRPYLSSPHYDDRLSGPIWARLWKPCLNCKELIRIHGGKYENFLVATGSAGAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRF0</accession>
    <name>A0A8G1VRF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purple acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_467418</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517630.1">
        <property type="nucleotide sequence ID" value="XM_025662187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRF0"/>
    <dbReference type="GeneID" id="37165589"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014390">
        <property type="entry name" value="Acid_Pase_Asper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF153">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000900">
        <property type="entry name" value="Acid_Ptase_Asper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034787740" description="Purple acid phosphatase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="80"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH59708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="614" mass="67169" checksum="84174D0A5617C034" modified="2022-01-19" version="1">MKGTAASALLVALSATAAQARPVVDERFPYTGPAVPIGDWVDPTINGNGKGFPRLVEPPAVKPATANPRNNVNVISLSYIPKGMHIHYQTPFGLGQLPAVRWGKDPRNLNSTAQGYSHTYDRTPSCSQVKAVTQCSQFFHEVSIDGLEPDTTYYYQIPAANGTTPSEVLSFKTSRPAGHPGSFSVAVLNDMGYTNAHGTHKQLVKAATEGTAFAWHGGDLSYADDWYSGILACADDWPVCYNGTSSTLPGGGPLPEEYKKPLPAGEIPDQGGPQGGDMSVLYESNWDLWQQWLNNVTLKIPYMVLPGNHEASCAEFDGPHNILTAYLNDDIANGTAPTDNLNYYSCPPSQRNFTAYQHRFRMPGPETGGVGNFWYSFDYGLAHFVSIDGETDFANSPEWNFAEDVTGNETLPSESETFITDSGPFGNVNGSVHETKSYEQWHWLQQDLAKVDRSKTPWVIVMSHRPMYSSAYSSYQLHVREAFEGLLLKYGVDAYLSGHIHWYERLYPLGANGTIDTAAIVNNNTYYAHNGKSITHIINGMAGNIESHSEFSDGEGLTNITALLDKVHYGFSKLTIFNETALKWELIRGDDGTVGDSLTLLKPSHAGGGKKFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRF1</accession>
    <name>A0A8G1VRF1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_483860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519757.1">
        <property type="nucleotide sequence ID" value="XM_025663191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRF1"/>
    <dbReference type="GeneID" id="37166593"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7443" checksum="5C3F17BE338AF66F" modified="2022-01-19" version="1">MARGNQRDQSRAKNEKKKQELLKSQKKAVGKGGILGKKEHDADKMRAKQALADQRKEAEALAAAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRF5</accession>
    <name>A0A8G1VRF5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_118941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519772.1">
        <property type="nucleotide sequence ID" value="XM_025653896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRF5"/>
    <dbReference type="GeneID" id="37157298"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050068">
        <property type="entry name" value="MurA_subfamily"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43783">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43783:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH61850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="697" mass="76136" checksum="304A18C8D07DE2B9" modified="2022-01-19" version="1">MMQTALHQPMGMTLLADAATSSLTALKGSTTSSAFSSLTVPPEPARTVVTVYSPGQEAIVQVVADILGKPWTTETSLSTFGPGSNAVVVGFLATEDSIASLQVDDPASCILVNTHCVDDGSFPDDALTERCHYEFLYSLRSPFFRRDLTRFLSLILGQTRPHEDLKTKNRTNFISTTFPDVHAALPNLDILSVGSDAVEIRVDLLVDPEPPQGAEVSVPSLRYVGQQLMLLRQHTELPIIFTTRCTKENGKFPMDDPMLFYKYLRRAIQWGVEYIDVELWLPEDIRRRLSEVKGNSIIMSAFHDFSGTWKWTSPEAPRIFAESAKYADIVKMIAMVTTIEANYELEYFRSTIKGTYGPYPLLSAVNMGQLGQLSRALNTVFSPITHPLLPMIAAPGQLTAAEINEALHIMGQLPKRDLYAIGSFRSTPQSMFMEKCFNELSLPHTLTSIDRGPTGSIERVITQPSFGGASVHPPIASGTSSIPAISEAAQAIGLVDTIVAMRGSGRPQQPAPPQQQLMGENATWKGIRATLTRDYVPSAYRGRAAIILAGSESEASATIFALRSLGVGAIHTVGFRARGPLAEGLEPFTSIQSVKMVEQPFVMVSALPPEKSLLVQPLLRHYRTSGRTSPPSTRGKVYLDLTRGERTGDPVGVAVRAGWTAYGIEDVDAWTTVETLRLLVGQNVPFDFVRMASGRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VUU2</accession>
    <name>A0A8G1VUU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bifunctional lycopene cyclase/phytoene synthase</fullName>
            <ecNumber evidence="8">2.5.1.32</ecNumber>
            <ecNumber evidence="7">5.5.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO85DRAFT_494918</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34475"/>
            <dbReference type="ChEBI" id="CHEBI:27787"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>all-trans-lycopene = gamma-carotene</text>
            <dbReference type="Rhea" id="RHEA:32219"/>
            <dbReference type="ChEBI" id="CHEBI:15948"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>gamma-carotene = all-trans-beta-carotene</text>
            <dbReference type="Rhea" id="RHEA:32239"/>
            <dbReference type="ChEBI" id="CHEBI:17579"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carotenoid biosynthesis; beta-carotene biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the lycopene beta-cyclase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.32" evidence="8"/>
    <dbReference type="EC" id="5.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521110.1">
        <property type="nucleotide sequence ID" value="XM_025663887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VUU2"/>
    <dbReference type="GeneID" id="37167289"/>
    <dbReference type="UniPathway" id="UPA00799">
        <property type="reaction ID" value="UER00773"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00802"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017825">
        <property type="entry name" value="Lycopene_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03462">
        <property type="entry name" value="CarR_dom_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480">
        <property type="entry name" value="BIFUNCTIONAL LYCOPENE CYCLASE/PHYTOENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RAH63188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="607" mass="68168" checksum="33342AB82642690D" modified="2022-01-19" version="1">MKQNGGRLYSLVRGVSTTNLFSTSANSKCASSHCTYTIPAASALTVIYYPFFAAQDCCKICILITIAILATIPWDSYLIRSAIWTYPPDAVVGPKILDIPIEEVFFFAIQTYITSVAYCIFTKPLVRPMYLRPHPERRRTRNVVAFVILTLMGGGTTCLLLGRHMTYLGLILVWVSPILLFQWMLSHPFLIGLPAKPTIAAICLPTLYLRVADSRAMESGTWRIESGTKLDYRIGGLEVESSNSNREALFFLVTNMMIVLGLVGIDYAYALQEYKSLSRPAADKGTMLRTALSLLCSLPSIDESLSALSQAVYCLQEKSQSMFLGSALFQGQLRIDLIFLYSFCRVMDDLIDEAEDDQEAKTWITECRYLLDLSHRGRLPHDACHASKQGGKYQRLYQSISYLPLSRLTENFFYDLLRGFETDLAFDPKKGGFPIKSDTCLDQYAGFVAGAVGALVLDLVLFYHGHDNTEDVPLLKRAAKEMGKAMQCVNIARDIHRDAEIGRVYIPTTWLDEVGLTPGDVLERPNIPIMYGLQERMLQKADGYYQVSREAIEELPRGVRGPLRATVESYMDIGRLLREQKGTSLARASKMRVPLMRRLKVGWLAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VUW1</accession>
    <name>A0A8G1VUW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_444549</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521170.1">
        <property type="nucleotide sequence ID" value="XM_025659036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VUW1"/>
    <dbReference type="GeneID" id="37162438"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH63248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="317" mass="33073" checksum="2C73781F11DF2628" modified="2022-01-19" version="1">MSLPKEAYLSNTWKDGLFTNKVVFCTGGAGTICSAQVRALVHLGANACIIGRNVEKTEKAAQDIATARPGAKVIGIGAVDVRKLDSLQAAADRCAQELGGIDYVIAGAAGNFLASINQLSANAFKSVIDIDVLGSYNTLKATIPYLVESAKKHRMDSETLKPSAAGTGGRIIFVSATLHYRTAPFQTHVSVAKAGVDALSHSVAIEFGPLGVTSNIIAPGPIASTEGLDRLLPSDTKDTYIKSQPLGRVGSVRDIADATVYLFADTGSYVSGQTLVVDGASWRMSTTGATSGKLAYPDFLLSGNPVPNVKGQKKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQZ8</accession>
    <name>A0A8G1QQZ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_454266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510135.1">
        <property type="nucleotide sequence ID" value="XM_025661243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQZ8"/>
    <dbReference type="GeneID" id="37164645"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF2">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="35"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="251" mass="28473" checksum="E182DE166EA3D469" modified="2022-01-19" version="1">MATGTTSRPWADGPWPLIETPSKTQDISKHEALHIANEMAFAHNAMLRGLNSLYLQAEQITESQDIADYLVFLRSWAGWVSHHHTLEEEQMFPQFEGVMKKPNFLEGNVNEHHTFQPILKQLLAYGTETKPADYKASTVRSLIEQMAPSFREHLANEITSLMSMEPYDGPALLKVYKECEAEAGKQDKNVIPPMVLGLRDITFEGGNQWPAMPPFSTHFVHYLFARKHAGAWRFLPSDTWGNPRPLAFGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QR41</accession>
    <name>A0A8G1QR41_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_464034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510195.1">
        <property type="nucleotide sequence ID" value="XM_025661964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QR41"/>
    <dbReference type="GeneID" id="37165366"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034318072" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="22230" checksum="385AB58EAEFFCEB0" modified="2022-01-19" version="1">MRLATHLILCLATIVCAREWATSTDIESQPLEEDDEVVSILKDDAVNITYKIGCDDSSQMTTCDAGEEITVVDGGPPTTGIPDGLIVVDGDELIYSPVTSPHMMTQTFGEEHDTVSTDTTPEPSQTEISMSWSSSSLAVSTHIVSLTTTGSVSDTSSIGSSVGSIQGSMSLMTTQSRASSASTSSSVRSTGAAPLATGEVAMMAGGAAMALLVAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS28</accession>
    <name>A0A8G1QS28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_493636</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ825093">
        <property type="protein sequence ID" value="RAH51807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509729.1">
        <property type="nucleotide sequence ID" value="XM_025663837.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37167239"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05611">
        <property type="entry name" value="STKc_Rim15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000340">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000664">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000377">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000119">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000139">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="13">
        <location>
            <begin position="45"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="739"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="1182"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="1550"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="308"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="500"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="546"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="699"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="925"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="996"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1260"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1313"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1505"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1692"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1956"/>
            <end position="2057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="928"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="1806"/>
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            <begin position="1957"/>
            <end position="1973"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
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            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH51807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2057" mass="225012" checksum="B537C260BDBD0A42" modified="2022-01-19" version="1">MAGNGTDDAQYLAPPAVTALRQEARSIDPRFSPTRSPSVDHMRQEREDLKEAAEQTLNVIVDLDLDGRVKWVSPSWKQVVGTSPVSIEGRMISEIVVGNQNVFHDAIESMKEDDSRSRFIRFAVHMGPDSVLKYSPEPRPAEPEHEATEATDIAEEAHAPAEKEDRHHDLLHLEGQGIMVFDRTADGVGHTMWMLRPFTEPREVTIDLPPLLVESLGVGAEVLANYLTTLAEAAASEPDPSKHPAPNPVLCRICERQITPWWFEKHSDLCLQEHRAEMDVQIAQENLNEHRHAIVKVLDALEARQSRPLVLGESNPPPTPQPEYKGLPIGPSPAASAPSSGSVSSANSAPGTPPRSRDHSASGIGHTRARSFAVRRPLARVVELILDLCDTALEINMPVIKESRADNSDDFRTLSPQSESRISQVLQWQSPSSNTLEQEQGLAALCTDTEQVAKAKVDAVIRHRRIVEYAERIRIEYTILVEECITAALTKAERIAAGQLSDSSASDDDAPQDNEPAVTASSPIIRGKRESTAPPAMSALTMSMRNSPDRFQSNHSSEGKASVAVSTGSNSPMECPTPRSHKSIAGVLGTSQPSRRGLSLIDLDAGDNSDSSVPSSAFPGAVRTDSPSSDRSMDRKRRSLVLPGLSSSPRRQHSPARVSGPHSPLRMPRARLSSGADSLPSPIVSPSANAIELAQIHYPHHRRQSSATSSDIVKPPVSPHLSSASQPQPRPAPPSIKDFEIIKPISKGAFGSVYLAKKKVTGEYFAIKVLKKADMVAKNQVTNVKAERAIMMWQGESDFVAKLYWTFSSKDYLYLVMEYLNGGDCASLVKVLGGLPEDWAKKYIAEVVLGVEHLHGRGIVHRDLKPDNLLIDQTGHLKLTDFGLSRMGLVGRQKRVLKSMNNEPAPDLLKQGSFPRATSITSSRSASFDFQGSGSPGSTPLITPDVASSIPQPSYFSLNQGGGLSRQTSRRASGYRSDSGASESLNAMFRTLSVNEGGEASGTMPVPVPGQHQHHHQHQLPEEESQSEAGESPHLYPLQPTMSNSFSYSTPPQQSMMPPLMALFDPEDHNRRFVGTPDYLAPETINGVGQDEMSDWWSLGCIMFEFLFGYPPFNAGTPDEVFDNILHRRINWPEDPEEYASPEAIDLVNRLMTMNPRERIGANVDEKYPNGGAEIRSHPWFSDINWDTLLEDKAQFVPNIENPEDTEYFDARGATLQAFAEELEDASPPQPPLTTGAYPQDRPHDALFKVRSHVNSMKRPLMPLHIPPHVRESRSRRLSEPTMADDFGNFAFKNLPMLEKANKDVIQKLRQEAMQAQQRHVPPTGSQQQGHAQGGQDQAPTQPAPPTLEGSPLPMPLQRTLSQTKGNNRPSSPSSMSQANSSPSRPSQPSSPLLVQFSTGQNHERRKTSGSSSNNSQSAGSSQPASVDQGRMASLKHGSASSSPIKPPRATAHSPDKTPSGQRHGSAPASRARSQTIGSQDGDLSSSLAKETYAVGHYKRRSQLFDISPSSSDNEDPRTKALLKVQRRRQSSRRMSQINFPDGPFFRPLDVLICEDHPVSRIVMERLFEKLRCRTITAVNGNEAMRYALSEVQFDIIMTEFKLPQVTGADVARMVRETRSANRHTPIIAVTGYLKDLPETHHFDALIEKPPTLTKFTEALCRFCQWKPPPKDYNPSQSMSVPPSTIRQAFVQAEHSPSSTASSGFAHVPSSSYRGSSREDSIVSSYFGDTESIKPDDGPVIVSHHNEPEQDRGGLGISEDVTRVQEATDGSSTSGSDAVPFPSLLHASSAPPTVHTSGNLTPRKQRSSEAIRAKRESLERKRYECAESGDDEDEELGNSQTRSSSPQQRSRRPGSKLGIEMMRTNSRGSVVSGSEELLKRERESLERRSSGGSGGASDYSEERIGTRSPHSPSLESRLENLSIPEEAIAGSVEGCSPKHSPIVELGSKMDIPAIFSDRSTSPYTTEASDTQAMEASVETPKLGHITPPIVFTKDGESEPSGDDPETPYIKTTGDNLTPDYGSEADVDRYLDADATPRPLHTPSPHPYLGSTHSQPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSV9</accession>
    <name>A0A8G1QSV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_505100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510950.1">
        <property type="nucleotide sequence ID" value="XM_025664322.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37167724"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1058"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1089"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1141"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1175"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1199"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1231"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1325"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="46"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="728"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH53028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1355" mass="152386" checksum="B2EA32B77521998E" modified="2022-01-19" version="1">MDTSSSSETVDIEPGHSSIPKQLTLTWRNVSVNVTAPDAALGDTLLSVADPRQISGWFSRSQRPKRTILKDISGQLRPGEMLLVLGRPGSGCTSFLRVISNDREAFDEVVGETRYGSMDHKQAKKYRQQIMFNNEDDVHFPTLTVNRTMKFALRNKVPRERPDHLHDRKDYVQEKRDGILESLGIPHTKKTLVGNEFIRGVSGGERKRVSLAEVMAGQSPVQFWDNPTRGLDSKTAVEFARMLRREANENQKTIMATMYQAGNGIYDEFDKILVLAEGLVTYYGPRAMARGYFEDMGFICPKGANIADFLTSVTVVTERTVAPGMEEKVPNSPAEFEARYRQSAIYSQMMNDIQPPEKLVKEDENLALAVAMEKRKQHVPRPQSVYTTGLWDQILSCTLRQFQILAGDKLSIAIKVVSAILQALVCGSLFYNLKLDSSSIFLRPGALFFPVLYFLLETMSETTGSFMGRPILSRQKRFGFYRPTAFAIANAITDIPIVLVQVSCFSLILYFMSAMQMDAGRFFTYWIIIIVQTLCFMQMFRAIGALCKQFGNASKMTGFLSTVFFVYGGYLIPFEKMHVWFRWIFYLNPGAYAFEALMANEFTGLELDCVEPDYIPYGSGYPSGSSPYRGCTVKGSNSEGVIDGAAYIKEQYNYTYHHVWRSFGIIIGFWAFFIFLTAIGFELRNSSAGSSVLLYKRGAKSKKPDEESNVSAKSEGAVLAQSGKQSTFTWSNLDYHVPFHGQKKQLLDQVFGYVKPGNLVALMGCSGAGKTTLLDVLAQRKDSGEIYGSILIDGRPQGISFQRTTGYCEQMDVHEGTATVREALVFSALLRQPDSVPREEKIAYVDHIIDLLELGDIRDALIGVPGAGLSIEQRKRVTLGVELVAKPTLLFLDEPTSGLDGQSAYNIIRFLRKLVDSGQAVLCTIHQPSAVLFDAFDSLVLLAKGGKMTYFGETGEESHKVLEYFAKNGAPCPPDMNPAEHIVEVIQGNTEKPIDWVDVWSRSEERERALAELEALNKEGQSHADYVEDQSNFATPVWFQFKMVLHRLMVQLWRSPDYMWNKIILHVFAALFSGFTFWKMGDGTFALQLRLFAIFNFIFVAPGCINQMQPFFLHNRDIFETREKKASPASTFIGAQAVSEIPYLIICATLYFACWYFVAGLPVDAYISGHMYLQMIFYEFLYTSIGQAIAAYAPNEYFAAIMNPILIGAGMIAFCGVVVPYDSITPFWRYWMYYLDPFTYLVGGLLGEVLWDVKVQCEPSEFIQFNAPSGQTCGQYMAEFISEQTGYLLDANATDTCSFCQYSMGSDYAKTFNLKEKYYSWRDTGITALFCITSYGLVFLMMKLRSKKTKSARSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT12</accession>
    <name>A0A8G1QT12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_430166</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510964.1">
        <property type="nucleotide sequence ID" value="XM_025658280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT12"/>
    <dbReference type="GeneID" id="37161682"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH53042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="542" mass="60763" checksum="8F4E6DA0F97AA69D" modified="2022-01-19" version="1">MGVQEPAPKKRTRVSHTKVRTGCRTCRIRHKKCDETRPICRMCSSTGRICDGYQQTIDRRTRASKLRLASTSPSSTSSSSSTVSVPSLVSDLILHTNEIDLTRQERWYLDFFRRNTAFQCSGYFDDDFWLRLVHQVTEAEPAVRHAAIALSALHCNFERTTTGQGTIDSRLPLQQCVKAISSLRHQLAGGGVPSSANMEITLVTCVLFVSFMFLQGDTQSACCHLRGGLKLLKEWRSTGKPGYSTTGAVLMKVFARLQLQWSTFADEVFIEEVDSNRCDAPYMEINDLSLEEPTDSLEKAGSLLVRLGRLVLTPNPSDPSSPGYCTVLDSRRMAIINKLQRWTAELDDSMTCTGNTLLLRDSTILTVLKLWSEIIYIMAATETRLGGSETRFDAFHLNFGRAVALAKILLLSTPAQSTMPNFSIGMGIIPPLFFCAFKCRDWYIRREAVQLLRSCQRQEGLWTTPGAVLVLERLIDIESKGLMPGDLVPESRRIDSIHVNILPDDHKIGLWYRRSSRQMGLDGYVDVGSGMWEKALLDYHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTB5</accession>
    <name>A0A8G1QTB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Utp8 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_443120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510359.1">
        <property type="nucleotide sequence ID" value="XM_025658864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTB5"/>
    <dbReference type="GeneID" id="37162266"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018843">
        <property type="entry name" value="Utp8_b-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10395">
        <property type="entry name" value="Utp8_b_propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Utp8 beta-propeller" evidence="2">
        <location>
            <begin position="26"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="903" mass="98090" checksum="7906D5C0B95C960D" modified="2022-01-19" version="1">MDLQPPSVLAHLPRPLHASTGKTHLGEVHSLADSKKRKRHEVVVAVDGEAVNIYNIQTPKLVTSYAVPPQSAFSCQPCSVRRKINKSLVRRQTYVAVKQQIKSFVEENGGNGSSAPSIGSSSYSVTDSESPAVFVGIVPTESKEEEEEGSFDVLAVHQDGRVRRLSSDLKTQHWSLRHSEVAKTSTTHEIRSCFLVEFEDAKKSLFKRRQDLAALAFGNLTETGVDEPSVLLLVSQPIGSQHTKLSDVKVQMFSVPANASSSGHDESQKMRHLITFNLPDIDGPETIETRGSQWYFHAGSAGLNVSFGQGYINFDLSQYTPTMTSKFILENEEFSSLMRISPQSVIGAGKSMIAVYDTQYKSVQRNIAVGDIPASASGIKARTTFVSYYAKLGVAIATKDNTLLAFDLSPSHNTANPSLKRSRDGLLIDAIGRGIGSAKKHRTEDTAVLGLSSPEEVERWNKLTADLHQCSEAQDADAFDHAVLAYFGSNGFPSPEDYVNPETTVHLLSLIFKLKDDASSQDQLSASSSFRLSINLWPQQTCQWLIQIGHLSPNNVEIALRRSFKPRILPSLPTGSFIQALTESDPSLERLIDVLQGRVLFSTDELAYILKLLINTARSRSVTLDEEAPKALTNGEDQDQAPTQALALSHAEPSLGNIFLALNTTLEKIHRHPLPAITTSIRSALSRTEIISMVHHLRLSLATGGYTSRFTESPPIPVPAEQTNPPISLSTIVDLLNASVDAIGPSGWISAASGVDDSITARDQELIADLKSEISAALAGIEEATYLKGILHEYLRYANSAIRSATTTVAVDSGSDTPTSAMVRLEKLNGADLMVFGATEDDDGLEGDASGKLLPLSLKAGSNDVSKTKVKLSTGEVKTRSSREIGYLRRKAAGKYSFERLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTH8</accession>
    <name>A0A8G1QTH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LEA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_405720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511500.1">
        <property type="nucleotide sequence ID" value="XM_025657309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTH8"/>
    <dbReference type="GeneID" id="37160711"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022124">
        <property type="entry name" value="DUF3659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054256">
        <property type="entry name" value="DUF6987"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461:SF1">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12396">
        <property type="entry name" value="DUF3659"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22485">
        <property type="entry name" value="DUF6987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6987" evidence="2">
        <location>
            <begin position="910"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="883"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1120" mass="119174" checksum="EF3C9BF259FC9346" modified="2022-01-19" version="1">MASPIASKVSKLNLSPDSKRGTPPKIRQQTPQKKTPPKLQAQESASQAEEPSAPSTPTPKGKVRQLQSEQRASPAPVPDDAQSQASGSASQIERPASELGAKAQDTAQSVQNGVEDQGVGQIDLSVLKGLQVGEDGLIHDQDGNAIGRLAEGQAEYLTGYTVGDNGEILDEDGDLVGVADVLPEAFQNDVGSVQEQAEETTDQAPKTINNIAELVDRPVSESGEIKDVNGNTIGKLVEGNPEDLAGYAPDKEGNILDDDGDLIGRVEIASQAEEAAEEVPEAKPITDIAALADRPVSASGAIKDDQGKPIGKLVEGNAEDLAGYAPDKEGNVLDDDGDLIGRVDIASQARQGAESVASSQRPASKLGRETVDDAEQRDTSTAGQAKEDVEEAAEEAEDDLPPLSTLEGLKCNKLGKIVDRETGKPVGELIEGDAKKISRLGAQLDDKGQFWDNRGNVIGKAKTLPVEEHPDEPPFGGLEGLHVVEDGWVEDQNGKRVGKISEGDAKKVLGRPVDEDGDVLDKNGNVIAKAEYYEAEDEPEPVPEEAPDLSSLEGLAPNKLGYVIGPKGVPIGRVVEGKVKELAGKEIHDGQIWDGPKPIGRVELIPPEEREKSAEGPFAGLENLVVNKEGLVEDDDGNVVGKVIEGDIKTLRGRAVDEDGEIIDKYGNVKGRAEPYEVEEPEEEAPDLSILEGKTVNKAGNVVDAQGNVFGRITSGDKRLAGRKVDGKGQIWGDNGKVIGTAELIPGAEEQKPEGAFYGFENPVVGKDGVITDASGQIIGRIVEGDAQRLQGRQVDEDGDILDKNGNTIGRAERWQPEEKPRDVNPMSGRKVNREGEVRDADGNLIGKLTSGNLPSLIGKEIDDNGYVVDNDGNKIGECTLIENIPEPEPEPEEPEEEPQEPEISPEEQEAQRKIEEDKQLAKKMSGIIAQTLDRIRPVCKMISEHIEKADRTPKDELDEEQLVKDVKPLLEEGNQILQECNGAIRALDPDGHVAATAKARAASHEASSEEYALAEQLKELTDLVVKTIDNGKKRIAGMPHAKKKLNPLWALLSEPLGQIITAVGLLLNGVLGLVGRLLQGLGLGPLVNGLLGGLGLDKLLGSLGLTSLTDSLGLTGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTJ2</accession>
    <name>A0A8G1QTJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_492899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510479.1">
        <property type="nucleotide sequence ID" value="XM_025663803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTJ2"/>
    <dbReference type="GeneID" id="37167205"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="65" mass="7270" checksum="D8A3663708D41F99" modified="2022-01-19" version="1">MPHKVNDSNSTLSSSGSSGDRVVVSDLRGPNAVPRRTQPPVIVHNRGGQIYDETRPSDWDKQRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTN2</accession>
    <name>A0A8G1QTN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TfdA family taurine catabolism dioxygenase TauD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_381471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511370.1">
        <property type="nucleotide sequence ID" value="XM_025656420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTN2"/>
    <dbReference type="GeneID" id="37159822"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000011">
        <property type="entry name" value="Taurine catabolism dioxygenase TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="88"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="400" mass="45348" checksum="E2789D67320B3E87" modified="2022-01-19" version="1">MVASTISQQADIDYMPDHDKYLARSKRRQETEELAMHLPEGFPTQLSGDLVWDARTIADRYDWNYQLSTGDISEIDGALRYFQSLSKPMGEICPNTFPLPKLHTTLRDISKQVHEGHGFKVIRGLPVDKYTREENVIIYTGLSSHVAPIRGRQDSKWQGRPADVMIAHVKDLSQSCNSKDIPGPVVTADKQVFHTDAGDVIALFCLNEGAWGGESYLASTCHVYNVLAATRPDLIKTLSEPWPFDDFAPTGDVYKLRPLLYYQSATGKDPERLMIQYSRRNLTGYMDCKRSAHIPPLTEAQAEALDAIHFTAEAHSISLDFRKGDIQFANNLSILHARGAFTDSNEKQRHLLRLWLRDPEYEWKKPSELKERFDRVYDGVTVENSVYPLEATIRSSNVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QU78</accession>
    <name>A0A8G1QU78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptide hydrolase</fullName>
            <ecNumber evidence="14">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_168948</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="14"/>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510854.1">
        <property type="nucleotide sequence ID" value="XM_025654274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QU78"/>
    <dbReference type="GeneID" id="37157676"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 14" id="KW-0732">Signal</keyword>
    <keyword evidence="10 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034656861" description="Peptide hydrolase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="15">
        <location>
            <begin position="174"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH52932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="391" mass="43408" checksum="140DE2F4554BB17A" modified="2022-01-19" version="1">MKLSIALALGATASTGVLAAVVPQQEPLITPQDPPTHHHQEKFLIELAPYQTRWVTEEEKWDLKLDGVNFIDITEERNTGFYPTLHAGSYVHYPSTMKHAEKVVPLLRGLSKDNMEQNLNKFTSFHTRYYRSSTGIESAKWLYSRVSDVIEQSGAAKYGATVEQFAHSWGQFSIIARIPGQTNKTVVLGAHQDSINLFLPSILAAPGADDDGSGTVTILEALRGLLQSDAIVQGNASNTIEFHWYSAEEGGMLGSQAIFSQYKRDKRDIKAMLQQDMTGYTQGALDAGRQEAIGIMVDYVDEGLTQFLKDVTTEYCGIGYIETRCGYACSDHTSASKYGYPAAMATESEMENSNKRIHTTDDSIRYLSFDHMLEHARLTLGFAYELAFAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUB7</accession>
    <name>A0A8G1QUB7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_453481</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511008.1">
        <property type="nucleotide sequence ID" value="XM_025661065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUB7"/>
    <dbReference type="GeneID" id="37164467"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="34"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="153"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="256"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH53086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="349" mass="37765" checksum="5F19F0D5F1A7CBC3" modified="2022-01-19" version="1">MQPVAHQSGGASGDPLPPSLPTEAIEEKASVSSLGSWNHLIAGATGGMVTAIVTSPLDVLRTRLQTDYYQTSGANRSIPTHAHVRQSFVKTSIRHFRETFGILFSIHRVEGWRGMFKGLGPSLTGVVPASAVKFYTYGNCKRLLPEILGCDKDTTLVHAMSAACAGIATGSATNPIWVVKTRLQLDKAGARRYKNSLDCTKQILQQEGPKGLYRGLTASYLGTIETTLHLAMYERIKGLISKEVNLDKNSDSNKFVQGLALSGASGLSKLFACLIAYPHEVIRTRLRQAPMADGRQKYTSILQCARLILKEEGVIALYGGLTAHLLRTVPSAAITIGTYELVLKVLEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUW3</accession>
    <name>A0A8G1QUW3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_452484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512021.1">
        <property type="nucleotide sequence ID" value="XM_025660832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUW3"/>
    <dbReference type="GeneID" id="37164234"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="95" mass="10263" checksum="C1ED4DB0BFB71FD9" modified="2022-01-19" version="1">MAAAGGLTGGHPPSVRYVSAFCIVDFIVQYINNCSSRNIAIFSVIGMIAGGWMFFRAQSPSKEEKLYSQKDIHTMVGGQTGENRVGRAPSHQKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVB6</accession>
    <name>A0A8G1QVB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_452594</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512149.1">
        <property type="nucleotide sequence ID" value="XM_025660859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVB6"/>
    <dbReference type="GeneID" id="37164261"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH54227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="313" mass="33696" checksum="1EC8D6B72FA77A19" modified="2022-01-19" version="1">MSPKTILVIGATGNQGRGVVQHSLSAGHSVSAFVRNPASSAAVQLAEQGATLVTGDLDDLESLRDATQNVDAVFFTEVQTGKPEADFQRMENIILAAKESSTISHIILGTALKTGQHESFPGWESGAHPMKEYWLNKHALENRVREVAEAKEGGRWTLVRPGHFLQNLLPPVRDFMFPAFKEERVLRVAYRPGTELPLVDARDVGIVVAAAVKDPERFANKAVDVAVEVVTVEQLAGKIGKVVGEEVKVEFLDDEVVDGMIKEGHLGAASSRWADEVPGGDGVSNCREQLGALAEGLTSVDAFLKENEKAILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVE4</accession>
    <name>A0A8G1QVE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_523106</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512194.1">
        <property type="nucleotide sequence ID" value="XM_025665318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVE4"/>
    <dbReference type="GeneID" id="37168720"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF1">
        <property type="entry name" value="TOP1 BINDING ARGININE_SERINE RICH PROTEIN, E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="288"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH54272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="364" mass="42111" checksum="66FE537C3B11E989" modified="2022-01-19" version="1">MSDDVDLQQEILQRTLQEVAHDEGEHDANPCVICLEPISEAAIAVPCRHANFDFLCLVSWLEQRRNCPLCKSEITSVKYNLDHTNGPKIYQLPASTSDTTTTSHLPTPSHHRPPRRPRRPRSPRPQQQQQQQQSSTDPLRRRQHIYRHQLYSLRVGSNRLSQYRELTPERFSREEDLVSRARKWIRRELQVFEFLNPEPEDQRQGGGGIARPGQQRLESRRGNNAEFLLEYIIAILRTVDIKGSAGQAEELLRDFLGRDNARLFLHELQAWLRSPYVSLEDWDRNVQYEDTVGGGGNARPSDSRREREERTATPVYRADRGPRFPGSSGRVNKPSYSRRGGRSSRDAVAQARRVQYARDRYVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVQ1</accession>
    <name>A0A8G1QVQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_104658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512435.1">
        <property type="nucleotide sequence ID" value="XM_025653804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVQ1"/>
    <dbReference type="GeneID" id="37157206"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH54513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="117" mass="12938" checksum="1DC95EBB46845DA1" modified="2022-01-19" version="1">MPAARVCGATERVDLVNLLWLTCIMILSTAYCRSMLLLCLLFPHAPTIRIFIILELHRNSRHRGSSSNGSEWSQLLVESSLLLCAPSNWGHTPPIHHGSSPRLAWTAPVRKSKATGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QW98</accession>
    <name>A0A8G1QW98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Bicyclomycin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_503885</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511696.1">
        <property type="nucleotide sequence ID" value="XM_025664263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QW98"/>
    <dbReference type="GeneID" id="37167665"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF138">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="41"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH53774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="990" mass="108615" checksum="DD260BB03875D093" modified="2022-01-19" version="1">MGQGKAIPPPLPNREDYVVDFDGPDDPQHPLNWPLFTKILISTIACFGTFIPSFASGAFAPGSAAAAKSFHVGSEVGILGTSLFVLGFAAGPVIWAPASELFGRRWPLTLGILGGAVFTIASAVAKDIQTLIICRFFAGMFGASPLAVVPAVLSDIWNNSHRGAAISLYAILVFLGPLSAPFIGGFIASSSLGWRWTLYIPAIVGFAWGGICILFLKETYASCLLVSKAATLRQQTGNWGIHAKQEEVEVDIQQLIQKYFTRPLRMLATEPIVLVISLYMSFIYGIVYALLEAYPYVFESVHGMGPGINGLPFIGLIIGQMAACGFVLSQQSAYVRKLAANNNVPIPEWRLNSVVVGAPVFTIGIFWFSWTGFTASIHWMAPTAGGVLIGFGILSIFLPCFNYLVDSFLPVAASTVAANIILRSSVAAGFPLFSKQMFANLGVQWAGTLLGCLSAIMIPIPFLFRAYGPRLRGEGKQTSRWGYECHYQAPRRVRSKPADRGTSICDQNEPILESSPREVGRFTETLEVNSGAAFVRKIGLKVDPANAPKLNLFGWNVGRRKSPAGLAPVAAFPIVEILSLMQMRTLANVFFSKVDPCYGFIDSSDFFRRMDSRWQPNAVESTYDGVLAGVAALGCLFSGTNINITESHLVELMRSISETHIGSVRPSLHLVTVWTLRVIYLRMTAPPYPCWVTSSTLMHLIEASKLHQLSTDDDNDVDIRRRLIGVAQHLNLWISYDLGLSRVPLCSDTLGLPSSRPGDFTTELLGLLPVTASLGPENQRPDQEIEELLHQTLNRSHTKPPSLLCQCNLVLCLLRRLRLTNLTASPTTMTKVLDLLKRSLCASREMVADCSPWHHVPNVPFQMISIILEMDTSPALELLPEAMQTLRVVASTYDTETMREAYNTACLLILLYERRRRADTRLLSTVLNEYQQSPATESSLQQMATSDEVSWLEGLVADVPTLQGLDFSQFLQPDMLRMSPDASAWENKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWP2</accession>
    <name>A0A8G1QWP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_499031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513180.1">
        <property type="nucleotide sequence ID" value="XM_025664049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWP2"/>
    <dbReference type="GeneID" id="37167451"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="28662" checksum="11B09757A78DCD2A" modified="2022-01-19" version="1">MWSFSFRDRIFDIEGEDFKVVRQLTEDDDAEVGERKVLAIAKRQDKKYLLKIRYQLDPEDCDIEDLDKTLKVAEQHYCHEVEAIDLLSTHGYGPKYLNHETHEQPDWMPFPGGYLEFIVMEFPPGKNVDDIREELTDTQRRSIRKQLAHLLELMRQNDYKLTEQHPSYLHYDARADRLYLVDLAGLGYTNSATSYPIDEESPYVTAFNIWRKEYSKPKRTPKSGDIPLSHQPIKKENQPPRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXH5</accession>
    <name>A0A8G1QXH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_471079</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512718.1">
        <property type="nucleotide sequence ID" value="XM_025662445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXH5"/>
    <dbReference type="GeneID" id="37165847"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="382"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH54796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="993" mass="111776" checksum="E5A33369229CE67E" modified="2022-01-19" version="1">MLSSCSPIMHSFKARAYSALVSSRLPSYKSIVNSHLRRRGSTIPTSSIHADEYIGQSGRHYQVERVLQEESSPPRQVLLATAGDQRFILKYIHEVNFEDLQDVNRRLRNNASHVRLAQDIIPEKSMFVFEYLTSHLLHLAQKDLSLEIRKKILKEALLGIAEMHEKDVVHTDIKADNFFVNWKQSDDGITIDKVQLGDLEDAVYIPPGSSMLGKQAGNWMWRSPEAHARGRVNKPSDIFSFALVCIYVVHKRVIFAVGDDELDEGIDRLAVVIERHISYFADKDGFHGFLEYLGDNPWASVFNITLNGFNQENPVRPFMLWKGVDDDFKSLIWAMTNFDPRRRLTAREALAHKWFDDAEYPYDTSIVRELLKNKRRSRGIRSCFPCRHRKVRCDGQVPCSSCVKRNHPELCRVPTSSETGNEDHPPSVAADVPQGPSQNYNSTNLENDTSSVNPGDATATLISRLEAIEKQIALLKADLLATAAATTTMPVSQPSPLTDSVAQLPGMRVRPASESPGRYVVEDATGATIYLGRHADAPLALGCRQTTMSPVTGDLSLQDALINQCMPRAYPFINLWGADATVSDVCQTLPEDSDVIRYWQAYQTKAYPFYPALAAIDEFAQALFAFLDQRMLAHEATTPSEEPSSSWMALLFAVLACGVQFSDDPIQERDLRSRVLSRLTVVARKLYSNQGADCGQFARHFNVCAMALIGHCLRNNLDTNSAWILMGATIRLAQSIGLHEASPSLPEAEQFERSRLWWVLIWQDTFLSFTYDRPLGTIAMNCPIPYKHDPDGLGFQECVFAICHQIIEEARQKTTDGPQDPLESMRRFKRQLDGIRDAAALFLADKRRCVSLQNHLERLALGVHLGYVTCRIDRVYLDGHTGAPFPTAIAVDCAQRAMQAIESFLDLHRYSASVCRSWAFVHNAVSCAITLKNLNHVPVDERRKSDLLVQRLIAVLEKEEKDSEWCDDDTNVRYFGPYSRALKALREICHSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXL7</accession>
    <name>A0A8G1QXL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxylesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_426108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513349.1">
        <property type="nucleotide sequence ID" value="XM_025658106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXL7"/>
    <dbReference type="GeneID" id="37161508"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="25"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="549" mass="59064" checksum="A6FE7CC0B99892F6" modified="2022-01-19" version="1">MRFLSQPTLTSNNALLSFLFSFRSTVGSSRFAPPKPYNYPSGSVVNATQSGAACPQQKDPIADFPIFDNVTSISEDCLTLRVDRPLNTSSSDRLPVLVWIYGGGDTIGQIYDSAYDPSLLVYGAAQKDVPVIYVAMNYRLGIFGFASSPALNESDSLNAGLLDQRLALWWVQDNIAAFGGDPDQVTIFGESDGATGVGLQLTAYGGKVPKVPFRRAIMESGGANADPGTTTNTSSKHTATLTNLVNCTASSSREELECLRRLPMKTLLNTAYSYELSLNSMGGMGVFIPTAPSSFIPDAPSQLLRTGQFARNIDLISGWCENDGAFFTSTTLNSSSDIAAFLQDSYPNLSNATIAKALDLYPVSNFSPDPSANISAHYFRASQMHRDFDFTCPSLLTIQTNIKYATNPANVSNYLYALNQTAFAEVFESSGMTYYGVPHFSDIMYLFNSVTGGLFKDISTASDRKLASEMGASWASFAYYGNPSRARGSVKGWGQAYAANTSSTTPELQVLGGPKMRFTGSGKGGAYGEDLVKRCAFWNDPVVASQLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYK4</accession>
    <name>A0A8G1QYK4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_488960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514708.1">
        <property type="nucleotide sequence ID" value="XM_025663570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYK4"/>
    <dbReference type="GeneID" id="37166972"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH56786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="125" mass="14561" checksum="D2935C75AE739730" modified="2022-01-19" version="1">MLDNCAFESSAYHIAENLQWSFDTRADAKDILIQQTMEDYERIAMHGKWLYVQEYQFDNHEEACVNLGIVDQTNPRMKGMQRGQELEFWQPVCINRVAEMVLYSCESRSKHILAKENDVTPSPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ29</accession>
    <name>A0A8G1QZ29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_480270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512717.1">
        <property type="nucleotide sequence ID" value="XM_025662998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ29"/>
    <dbReference type="GeneID" id="37166400"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00302">
        <property type="entry name" value="cytochrome_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000090">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF218">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH54795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="553" mass="61937" checksum="98DFF76CB74942D9" modified="2022-01-19" version="1">MQCHFYLIGEAVATAQCLEVDTLWKFEDLQRAVGGVFHVVQPTGISFHTSSNDTLKTVSEVLAAATSTSPVGLRIDGNAVQAPQGPPGLPLVGSFYEIYPDHLGNHYRLFRKYGPVIKTTNMGKTIYLTDDPQVAAACFAESAYMTKKINSDHPLWGVKDNTAIFIGDTETENWRLAHKFLPPAMGPKAVRHYTGLMQECARKSLPVFDELDVRDESWNVYQYMVKLASQTIGRFSLGKDFGHFDAVDSPLHPIVTNIASLLSLNKKITARGEWYRHMPFGDPARLRHVQHTIYSLLQEQVDKVTAESRSTDAPMADAALSATCVVDYLLHAVDETGAHFPPSLILSNMLIVTGAGFTTTSALLSWLIYCLVTYEGTQDRLYAELVEYGIVGPAGERNETAWTPELAHSLPYMDRFVKETQRLHNASFQPGRTTKTDVILPGGYLLPPNSVIVPALYAIHTNPKVWRDPFRFDPDRWDTDEVKSRHRCAYVPFATGPRGCIGFNFALLEVKVLLGELVSRYEFVRDGQEAIDYDPEFQLIRPLNFYVRAKRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZF6</accession>
    <name>A0A8G1QZF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phenylacetyl-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_450129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514665.1">
        <property type="nucleotide sequence ID" value="XM_025660306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZF6"/>
    <dbReference type="GeneID" id="37163708"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="481"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH56743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="582" mass="63778" checksum="2BCA68EBF1C6A548" modified="2022-01-19" version="1">MVFLPAKEAGTLPPIPDNIPLSEFMLTDLYGRNPLGYSRDPFICGITGKSFSALEVVDRVDYLSRALSKELNWKPNTGTEWDKTLAIFSLNTIDTLPLSWAVHQLGGLVSPANAAYSAAELKYQLLDSKAKALFTCLPLLQTALEAASLAGLPKDRIYLLEVPPQLTPGVKAPAQFKTVSQFIEEGKSLPKVERLNWAAGEGSRRTAFLCYSSGTSGLPKGVMISHRNVIANVLQIQAFEGAWRDSLRAPGTQGNHTEVALCLLPQSHIYCLVVICHAGPFRGDQAVVLPKFELDLYLASIQNFKISSLFLVPPIIINMLRNHETCAKYNLSSIRSIFTGAAPLGVETAEDFQKLYPNVIIRQGYGLTETSTVVSSTHPTDVYLGSSGTLLAGVEMRIVTPEGKEITDYDTPGELVVRSPSVVLGYLNNEKANRETFEDGWMRTGDEAVVRVGPKKTEHIFIVDRIKELIKVKGLQVAPAELEAHLLTHPAVADCAVIAIPDEAAGEIPKAIVVKSPSFRGSDEEAIQSIKKHVEEHKARHKWLKGGVRFIDAIPKSPSGKILRRMLRDQEKEARRKAGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZV2</accession>
    <name>A0A8G1QZV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_460279</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514860.1">
        <property type="nucleotide sequence ID" value="XM_025661710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZV2"/>
    <dbReference type="GeneID" id="37165112"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.90:FF:000003">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000004">
        <property type="entry name" value="Nucleosome assembly protein Nap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="352"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH56938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="411" mass="46587" checksum="17B9944F54218F1B" modified="2022-01-19" version="1">MSEPIRNKKADFPVAPTPQNTPANNAPISSHAQQPGIASIKEESLDHATAASLFARNPGLVSMIQGKLGSLVGRSSGYIESLPVSVRRRVAGLKGIQKEHAKLEAQFQEEVLELEKKYFAKFTPLYQRRSTIVNGAAEPTDGEVEAGQGDEEDVDSKDDAEATKEEDQESQIAGIPEFWLSAMKNQISLAEMITERDEEALKHLVDIRMEYLDRPGFRLIFEFSENAYFTNKTISKTYYYKEENGYGGDFIYDHAEGTKIDWKAEKDLTVRIESKKQRNKNTKQTRIVKITVPTESFFNFFSPPQPPTDDDDTVATDIEERLELDYQLGEDIKEKLIPRAIDWFTGEALQFEELGDDMDADDYDDEDDEDEDEDDEDDDDERRSDRDVDDDSDEEDGTSKPKKEAAECKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R021</accession>
    <name>A0A8G1R021_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_449775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514965.1">
        <property type="nucleotide sequence ID" value="XM_025660229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R021"/>
    <dbReference type="GeneID" id="37163631"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="154" mass="16924" checksum="BE4E67FB6AC59BFE" modified="2022-01-19" version="1">MSLPSQRKFNLNANKANPAVSGGLRRSNAQHRKHQDLVPLMFDPAQALTFDQSSNSWKRQEFKQDPLNELTIRPGAEQSRYKDKGKRPANMNAWSAKCGGVCSTTTTMASKSSTSLNPGSVVSSSGQLAGPTRERGKIETDPSKVRWPLIGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0C5</accession>
    <name>A0A8G1R0C5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_437992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515668.1">
        <property type="nucleotide sequence ID" value="XM_025658651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0C5"/>
    <dbReference type="GeneID" id="37162053"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="200" mass="22557" checksum="4F3439E5A47B5B0A" modified="2022-01-19" version="1">MSTIKQYTVAQNLIPHILATTTPKGALLRYLCVPFMIWIFSLMLHPVKTPSHVTSLSAITAWFNILSALDPLLLNPKEADDFVAINEGTSKVKSFFYGLRTALKQHLNTQKINTPEKAKNTPPMPRYYTQGNGRNASKPISRRRYLIRETAIAVWQYLVLDISTSQAVKSGLSKSEQQQQQQQITFVEDSWKVLASTAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0X1</accession>
    <name>A0A8G1R0X1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_438468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515261.1">
        <property type="nucleotide sequence ID" value="XM_025658671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0X1"/>
    <dbReference type="GeneID" id="37162073"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="41"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="304" mass="34162" checksum="25AC8A1A0C4A7F2B" modified="2022-01-19" version="1">MDAKFKVFDEIEITYKTIRDTPLTTSILIPKNVKGQRCPVLVHFHGGGLMVGDKMFAPWFPLWLAQFAESHGAIIVTPNYRLIPEAKAVDILDDVKDFWDWLHLSLPNEVEKFRKDLSPQLSKIAVAGESAGGYLSLQSAFLFPEAHISVVLAQYGTLDIDSPFYNPQPTGPLQGSSVVNNYLANLKPGSIRVSSPMPDRWDLCEAILAEGRHRELIGNEDKVRLMKTLEQAQTPPAMWLAQGTDDPIMPLETAMNFVEQMKKSHPSTPLHVSIQPGSHGFDCMTTFHEDWVKEGCKFVEKYWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R130</accession>
    <name>A0A8G1R130_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endo-chitosanase</fullName>
            <ecNumber evidence="11">3.2.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_496275</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Chitosanase catalyzing the endo-type cleavage of chitosan, the deacylated form of chitin. Chitosanase may be crucial in the degradation of the deacetylated portion of chitin in the fungal cell wall. Chitoolisaccharides produced by the hydrolysis of partially N-acetylated chitosan are known to have many biological activities, including antibacterial activity, immune-enhancing effects, and elicitor activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endohydrolysis of beta-(1-&gt;4)-linkages between D-glucosamine residues in a partly acetylated chitosan.</text>
            <dbReference type="EC" id="3.2.1.132"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 75 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.132" evidence="11"/>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515134.1">
        <property type="nucleotide sequence ID" value="XM_025663951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R130"/>
    <dbReference type="GeneID" id="37167353"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016977">
        <property type="term" value="F:chitosanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009939">
        <property type="entry name" value="Chitosanase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061:SF9">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07335">
        <property type="entry name" value="Glyco_hydro_75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034968275" description="Endo-chitosanase" evidence="11">
        <location>
            <begin position="24"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH57212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="243" mass="26181" checksum="A00E334F64EBD3A1" modified="2022-01-19" version="1">MHLLTTTLLLLSTTAPLLTTAYSIPPNLSALYNKHKSKPCTHPLATGFHDGQNPTDSTFTYCSDLSNRSIFLHSPTLGGRYDNMDIDCDGANSHGGNCGYDESIQDQTSFKDIVSSQYGIPDLDANIHPYVVFGNTDYDPQRDGMWPLSVMVVVCGDQLFYGIWGDTAGGSWTGEASIALAKLCFPGDGISGNNGHVSDDVLYIGFVGGEAVPGNRADWKAGSTWEFEESIRALGERLVATLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R296</accession>
    <name>A0A8G1R296_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_420918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516165.1">
        <property type="nucleotide sequence ID" value="XM_025657910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R296"/>
    <dbReference type="GeneID" id="37161312"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH58243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="414" mass="45925" checksum="80925A161D576A77" modified="2022-01-19" version="1">MESNKQYDLIVLGPTGYTGRFCADHIVKNFPTNLKWALAGRSLSKLENIAKELKNVNPDRAEPDLLAVQLNREELHPLVQKTRVIINCVGPYCLYSTPVIEACASNGTHYVDATGETHWVKEIIGEYHETAKANGAVIIPCVGIESAPADLLAWATVKRVREDLSCHTRSITGDIHEIKSSGASGGTLSTVLTFFENVPPSEMRKISTPFALAASAPPKDIPREPLWARLLGIRSVRDMGILTTSPSGLADTTTVHRSSTLMPEFYGPRFYFRQFLRARNAFTGILWHYTFLFAITALLLPSVRTLVRKYIYTPGTGPTLEDSVNDFVEYRAVATADQDTPTPQRVLGKLRYQGTMYEFTGLSLAEAAMTILENEEKVKKVSRCGIVTTATLGQEFIDRWDKVGCHIETQIVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2S4</accession>
    <name>A0A8G1R2S4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF1772-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_478360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515116.1">
        <property type="nucleotide sequence ID" value="XM_025662895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2S4"/>
    <dbReference type="GeneID" id="37166297"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH57194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="198" mass="21303" checksum="9F28693653831E84" modified="2022-01-19" version="1">MYTTDTLPTSFCIAQAIGLSGAAWLSEYAGNIFSLSLMTIPALLQSHKEHSIPLSTITKQWALVYETGKNRAPPIALFTATTLLYLSWETRAQSTLSAIAPRGATTTYAIAAALTIAIVPWTILAMKGTNDALMEKAKVGVQEEKDLQEGERVLGLLNRWALLNGARAMWPLAGFLVGFVNGGITVSRQLFGNTVTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3A3</accession>
    <name>A0A8G1R3A3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_486859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517183.1">
        <property type="nucleotide sequence ID" value="XM_025663412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3A3"/>
    <dbReference type="GeneID" id="37166814"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="168" mass="19155" checksum="64DD436E93488C0C" modified="2022-01-19" version="1">MEPTPLADAITTPVPAVDLILEDRCRDFAIADVTHIIVKLPLGILNSIMESCAVSYNPNQPRLFREIIGKAISKAFFGDKQQLQCMKSKQIRNMEYIGYRNVHRTETPIKSPQVIVVALLEPVPGQNLKAVWKPAPELTPAKIRERTRLRAMENSVREQYRRWGLHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3C6</accession>
    <name>A0A8G1R3C6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_274390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516319.1">
        <property type="nucleotide sequence ID" value="XM_025655131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3C6"/>
    <dbReference type="GeneID" id="37158533"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF2">
        <property type="entry name" value="RESISTANCE PROTEIN ARS2, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="671"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="579"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="803"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH58397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="916" mass="102448" checksum="2AC3F689EC94E6CA" modified="2022-01-19" version="1">MDSYESYGSPGRSREAGDPYASRVPVDSYRRRSPVSQDRRRARGRSRSPVMIDRYEPSDRRASRDDYYAASREHAGRDREDRRRAPSPNVANIDRYVPGQDSVKRPLPTNPLPNPLTLEFQVGFNWFAEWWRAEQSIKEEKERAKHGGRRPSDRVKGEREAREDRERERAQIQAAYDSYKVNLQAKMARAFVQHHRNEEWFRERYVPEVRDPLRRQLMDFRMGAYQQWERDLESGLFDEFTLEGIYKSESDGAGGVIEKEEGETTAVGETLGVLDLLPARGGDLRDEALSQSALLIKTLAPNVSREKIEEFCKEHLGEEDGGFKWLSLSDPNPSKKYHRMGWIMLHPAPDVEVVERGDGREEEGEEMEHDHAANGSGTQTAAEKALEAINDKTIHDPVHGDFVCHVGVHVPPSQPRKKALWDLFSSPERISRDLELARRLVSKLDDEMGAGADGFSKIEERVEELRGKGWLQPPVTGPVSVKKRKPDYDADDIDEGEAEEGEEQEGWEDDELDDEELLAKKKKLDLMVEYLRRVYNFCFFCVFESDSVHELARKCPGGHLRRPRAGLTTQSKAVARASALGQPFPVKKKEPSEEGEEQPPVSEEKRPQRFSSKTEQQLQRAFNWVKTFEDKLLQILEPENVDIGKLGGKPVEDALEEELAKYMKQEDESKYRCKVPECTKLFKAEHFWRKHVEKRHTEWFENIRSDLALVNAYVLDPARIAPSRSDANSNGHFPLNSGQGQTGTPRGFSLASMPPYLAGSGNVPPSFQSVPGSGVPGFMGVNNPSWSGNGMVSADGPGLHQPGVMRRGGGRYNNRSGPYDRRGNRHGGPGTGSGRLSPVRGMSSMYGSGGRLPASSGPPYIPPGHPAAALVGASGFVDAGAGQQGMGPREAVQGRSLKSYEDLDAVGGSGSGELNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3D9</accession>
    <name>A0A8G1R3D9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4396 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_396268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515699.1">
        <property type="nucleotide sequence ID" value="XM_025656992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3D9"/>
    <dbReference type="GeneID" id="37160394"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025509">
        <property type="entry name" value="DUF4396"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14342">
        <property type="entry name" value="DUF4396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4396" evidence="3">
        <location>
            <begin position="84"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH57777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="222" mass="24228" checksum="38C09CFB058EECCA" modified="2022-01-19" version="1">MTPNMLLYRTSPILHKTPHTRRLFSILSPAQACRSTTTQTPSCSKSSPSPTTTGKSSPSCSTTTEQPQSTNPFTFNFWTSKPAWKRASINTLRCLVGCTLGDFSALWILQTYYPHLGMGLIMGASMASGITTSIILETILLRRGADQLSWPAAARTAMGMSLVSMLAMETAENLVDYHLTGGMVNMADPMFWTAAATSIAAGYLAPLPYNYLRLRKYGRACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4I6</accession>
    <name>A0A8G1R4I6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_450091</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514602.1">
        <property type="nucleotide sequence ID" value="XM_025660301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4I6"/>
    <dbReference type="GeneID" id="37163703"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09397">
        <property type="entry name" value="LIM1_UF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000119">
        <property type="entry name" value="LIM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000105">
        <property type="entry name" value="Similar to LIM domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017351">
        <property type="entry name" value="PINCH-1-4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210:SF14">
        <property type="entry name" value="LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="568"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="696"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="440"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="534"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="722"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH56680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="783" mass="84409" checksum="1CBCF18D765EAFE8" modified="2022-01-19" version="1">MASIMEGGLLPMIKCSNCGMSVEISSMGDHVCVKPMPATLSPSQSPPPPPPKSDNVLPSRTPSDAWASKSGRSGPPPRIDPAMANRPFLNPASPIANHDPLVPSPLSTSSGQRSPFRALQRSQTSPLPDEPQSPDSINLETAFATFPLPRSMSDRRPGGMSNVKDPRSAPPMPSARLAPALDRNELDDDVPPPPLPKDDAPATAMGVGHRHGASIDSKSSYRTSLASTRYGDNRNSKRSTAMSSRRPSFGSVARDPYKFVDDAPPVPSAAPQQLLRPSRISDTSVAGVADKREGRGEIYSGFDFGVSERPTSAKAEIDHVNASALRVSSHTNSNSDRLSSNRGSAELFFQSPSQSSYGPPLDFELPNEPLASPATPANGEYKAFKPQSSEFLQPADAESGRTNERDTNQRKDSDSTSEGNNSVSNFARALGLEVDHTANDSITSSDSSPSDTTRSGTSLSSLPSEASMSRQKPSDQGRLGPVVEEEKKSQQPVLDEPVLESPTELEPPRIPEALFSPDSPTDPAISQGSLSLVAEKKPRRPEEESPPRQEVVRSATAPQPRPSPRPKGPCRGCGEMIMGKSVSSADGRLTGRYHRACFVCFQCRTPFQTADFYVLEDRPYCAQHYHERNGSLCQTCHTGIEGQYLETVERRGRGPADRQKFHPDCLKCRTCQIPLKGDYFEWYGQVYCERDARRAAAATPPPPRPRRPTMPSSPLAPSGRGYPPPPPGYMGPPGPGPNGFGPPRGRGRGLRPPGPVDGPYAAAGPLPPARRFPERRTTRLMMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4U3</accession>
    <name>A0A8G1R4U3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_436542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517500.1">
        <property type="nucleotide sequence ID" value="XM_025658576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4U3"/>
    <dbReference type="GeneID" id="37161978"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="117" mass="13094" checksum="F43F703B68F4F9D5" modified="2022-01-19" version="1">MFPTRVLRMQASRPFAFPAPKENHSGMGFPPRPHYLSASAHSEESPPGVDPSRSGPWSNPDRLPPPFLSHSAVFICPPLTQFHRSVAVGAAIYSSTRKLMTDKTLRLYRNSPEDREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R638</accession>
    <name>A0A8G1R638_9EURO</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_448276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517278.1">
        <property type="nucleotide sequence ID" value="XM_025659899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R638"/>
    <dbReference type="GeneID" id="37163301"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034430885" evidence="3">
        <location>
            <begin position="19"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH59356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="383" mass="43156" checksum="A37508D2A43044E7" modified="2022-01-19" version="1">MRTQFLCLAGAWLASCAASPVASHPGDASVPQMALKDSHAPFPVVTGHEIHIPCATIPGLKEGEAKDVSKAYLAMKLRTESNALFVNDVTVFPSSFPMHLPATRYQDASRQNAEHLLLQYAMDIEYMPPRPDGSLVQDIYRVQLKFFDLSGRPATTDTVSVRLSSQQSGELYITQISVEPLPHYHDAHGDGNCVWHAKYWNLIMEKYRTWREKKGHGAHKGPKSQESDDHEHNDHHHHHPKERPATHEGAEERRPFLKERPTAHEVDKENSPQLPTTDSNKAAPDSPFRVYGVDKSLRPTALRNKDYRRDFWRLVVPAIIPGLLGAVAGLVVCTMGLLLWKVVACTCVSMQQGRRCRKRCQRKQGVFLSEKQRLLQQDELSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6W3</accession>
    <name>A0A8G1R6W3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_447493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517529.1">
        <property type="nucleotide sequence ID" value="XM_025659736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6W3"/>
    <dbReference type="GeneID" id="37163138"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000481">
        <property type="entry name" value="Alcohol dehydrogenase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="15"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="368" mass="39590" checksum="51CD7B247FC3532C" modified="2022-01-19" version="1">MSKAIFLNPVDGKPGKPGQVYYPLAVKTLPQPVPQGREVLVKLTATSLNHRDVFLRQHLYPGVTFDVPMGADGTGTVIAAGEGVRDPQRWIGKRVVINPGVGWKESLDGPEDPKGYRIMGGTKSYNKGTMQEYLAIDEGELEEVPEHLSDAEAASFPLTGLTAWRALVVKAGERNSSKGAAVLVTGIGGGVALMALKLAVARGVDVYVTSSSEEKIRKAVELGAKGGVNYKQEKWEQKLLELLPTGKVAFDAIIDGAGGDSVDKAVKLLKPGGALCVYGMTVAPQMPFSMKAVLKNIDVRGCTMGSRKEFKEMVEFIKTHKIHPVISRVLQTDLEDIPAIDGIFEDMKEGKQFGKLVIEFGKTSGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R712</accession>
    <name>A0A8G1R712_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_228183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518390.1">
        <property type="nucleotide sequence ID" value="XM_025654758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R712"/>
    <dbReference type="GeneID" id="37158160"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="104" mass="11825" checksum="4BD5C73EC1332070" modified="2022-01-19" version="1">MGRLTQDTVRTTCRRGREEEREREMDGRRINGGRRRCAAETKKRTTGSPAKMWRRRSGGKESKKGEKCGRKARNQTKHAKEAEKEGEEEAAEADGCGRESEKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R714</accession>
    <name>A0A8G1R714_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_485917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517366.1">
        <property type="nucleotide sequence ID" value="XM_025663351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R714"/>
    <dbReference type="GeneID" id="37166753"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12600" checksum="538347AED518F5C7" modified="2022-01-19" version="1">MENHVSWEQTPCELNLGSLGPICGLQRIDDKVHRYVRVPYALPPIGAYPDETRLDATIFGPVCPQAYLSSSARKTPGSNWTLVNAPPPGQRRPVVYRDCFAMGDLLNELVIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R750</accession>
    <name>A0A8G1R750_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_392366</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518450.1">
        <property type="nucleotide sequence ID" value="XM_025656843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R750"/>
    <dbReference type="GeneID" id="37160245"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="285"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="445"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="546"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH60528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="579" mass="63249" checksum="930CE12B9F6C3190" modified="2022-01-19" version="1">MTLFILTETSAGYALLKAKDKKLLKRDDLATEASTAEGVSNLLKLKSFQKFDSAATALEEVASLVEGKVTPRLASLLDEVKDEKKVSLAVADPKLGNAIGKLPGLSIELVADSSTTDVFRAIREHLPTLIPGLLPQDMSTMSLGLSHSLARHKLKFSPDKIDTMIVQAIGLLDDLDKELNNYAMRVKEWYGWHFPELAKILNDNIAYARLVLKMGMRTNWESSDLAEILPEEIEGAVKAAADRSMGTEISQEDLEHIQALAEQVVGFAEYRQQLAGYLTARMNAIAPNLTALVGDLVGARLIAHAGSLTNLSKSPASTIQILGAEKALFRALKTKHDTPKYGLIYHASLIGQATGKNKGKMARVLAAKASLGLRVDALAEWDDDATEEDKAALGTEARYNLERKLAAMEGKPLKPRGAAIAPNGAPQAQNFEINEARKYNADADAVTGDEPASAKMSKSKKLVEEVQDEEMADADSDEESDSSDEETDKKSKKSKDSELEKMAEKAGLSLKRYKRKLERGEIQFDAEGNPSAVSKKDIKKAKKESKKSAKGEEKKRKRSDDGEVDNSEKKKKKKKKGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7C0</accession>
    <name>A0A8G1R7C0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CST complex subunit Stn1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_476258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517516.1">
        <property type="nucleotide sequence ID" value="XM_025662767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7C0"/>
    <dbReference type="GeneID" id="37166169"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="30347" checksum="F27FFC0E76641B50" modified="2022-01-19" version="1">MGMATAQNHDGLDFYPAYCFKASPTHFTWVKMAAVDVLRLKRRPEFPDPKTYFYKNHPIQYISLLGIITSRTDLPTLTILTIDDSSGATLDVVVQKAIPTLTISTSTPQSGMYNTHISPTTALPLDITPYPPGTLAHVKGTVTTFRGVNQLQLERVFPVRDTNAEMRFVDQRSRCLVEVLDVPWRLGREEVERLRGEVEVGGEDGGVGVGVDEEEERGRRRKRRREEREERDRRRIWKMWEREERGREREAEQKRKEGQGAKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7D8</accession>
    <name>A0A8G1R7D8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_256411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH60016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517938.1">
        <property type="nucleotide sequence ID" value="XM_025654983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7D8"/>
    <dbReference type="GeneID" id="37158385"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="168" mass="19917" checksum="DF49E1FD9D5B7499" modified="2022-01-19" version="1">MAWIRQSCIPLLSLHRQTNGHISRSPCHPEYSRRGRVAPVHGSHGPSLHSDRPSWTILRYTDRMAAELYEYDRALWFYFCNEEKGDKVKQVFMEHDRYVHKVVPPERLLEFHRQNGWKPLCRFLNLRKSQTPYPMRNDSGGRQAAMDELWRRCVRRGIMKITPSVIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7E4</accession>
    <name>A0A8G1R7E4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_518632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517799.1">
        <property type="nucleotide sequence ID" value="XM_025664982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7E4"/>
    <dbReference type="GeneID" id="37168384"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH59877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="401" mass="42733" checksum="B061CBC431B7CC37" modified="2022-01-19" version="1">MEGLFTLLALSIVMAITSFVVGSLPLAFTLSPSQLRLISSLGMGVLVGTSLIVIIPEGVETLYSANSLSSRKELSSRSTTAVNWQHQAVPVTNFPRTLEGLDSSDVELTPRSVLSDLPSAPVTVPTTHSTLDERPRIMGRKDDTSDDHTGEDHDEDNSPHAWIGIALISGFILMYLIDKLPVFASSSKQERIPYHISLDNLGSGLRRNSSPSREGGLLDAGNIPRRSHSFATTTGLVIHAAADGIALGASSSDTGLSFIIFLAIMVHKAPASFGLTSVLLKQGLSSRTARAHLLIFSLAAPVGALMTFLFVQIMGSGSEGDGVGNRWRTGVLLLFSAGTFLYVAMHTMQENSPNSSSRESQVNGYGDHREAPSASDKSMRDLIASVVGMVLPLFLQIGHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7H4</accession>
    <name>A0A8G1R7H4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lipid droplet-associated hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_444944</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519433.1">
        <property type="nucleotide sequence ID" value="XM_025659146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7H4"/>
    <dbReference type="GeneID" id="37162548"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH61511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42310" checksum="B2013638AAD99FC9" modified="2022-01-19" version="1">MAPSMQPHVTPDSFFHTTSPPRPTLPTNPPPAPILVYFISGNPGLISYYYPFFTFLSDKLQSLSSSSSKQKKPHHQFYIHGHSLAGFEVQPQSPLPTHYHNVEDQIQFIQHKLDSFVQATTTAQSSRTVRRPRVIIMGHSVGTYIAMEVIRRHRERQTSAHANTTSTTDFGIIGGVMLFPTVMDIASSPSGKKLTTLLSLIPHLALIVSIFARFLTTLLPDFALRALIKLFMADPPSQAVDTTCAFLKSKTGVRQALHMAADEMRTITTDKWSDDVWGIASSSSSSSSSSSSSPSSSGGNTDDDKVHNDDTDSTSRMFFYFGRNDHWVAEKTREEIIQAKAKSSSSMVGGPTMVVCEDGLPHAFCLRHSEVTAGKVAGMVMDIVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7J1</accession>
    <name>A0A8G1R7J1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_518160</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518569.1">
        <property type="nucleotide sequence ID" value="XM_025664954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7J1"/>
    <dbReference type="GeneID" id="37168356"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11051">
        <property type="entry name" value="CYP59-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000088">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF107">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH60647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="571" mass="64727" checksum="226AE79EA3DEC68F" modified="2022-01-19" version="1">MVEARDIKFTPMASINIILTICLPFVSLAAYGLHALYQHRSKINRLRKQGVRMPAGWSWLTGHMLVLSDYVNSLPDDANVVLATQELASEYTDTEIFLLDVWPMSPAQYIVFYPEAASQATNKFNLPKTVIQPRFMQPITGGPSMISMGNAEWKAWRSIFNPGFSAGSMQDLLPEVIKSVGVFCDKLHEKVNAGKFFALDDLTTRLTMDVILKVTLDADLDHQNSDNIIATALGHITRWHSFWDPRIRAHPLRPIVQGYYGRVVNKCIRKALHERFSEMKQAKRDDLSRSKRAKSILTLALEAYLESKNEGITDSTQLDDGFAEYVTYQIRLFLFAGTDTTSSSIAYVYHMLSKHPEALARVRQEHDRIFGPDPSAVVQLLREQPSLLNQCSYTMAVIKETLRLYSPAGTMRQGADGLSLTDRHGNQYPLADDLSVTILHQATHLNPRVWPRAREFLPERWLVDPGHELYPDPAAYRPFEQGPRNCIGQTLVYNEMRTVLVMTARTFDIKPAYDELDAMKAKQRGWFDHIAESVGFQNKKPKLLHGERAYQSEKAGTHPVDGYPCRVTLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8S1</accession>
    <name>A0A8G1R8S1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_223888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518236.1">
        <property type="nucleotide sequence ID" value="XM_025654731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8S1"/>
    <dbReference type="GeneID" id="37158133"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="175" mass="20434" checksum="156EF2DE006D187E" modified="2022-01-19" version="1">MTPLKRRTKYRQKFYPTISGLLFLGRPEDEKKEGRKRRSRTGGVSLKVRASPLHTSVLLGLCFLVRIRRRRLVTCDRAMLLRMIYRDDGIQLSLTHSTRRAALWVEVDNIEPWSSNPIPREIHHPLPTLPLGTPNNYHSHIVVTKGICRTEPTTSSRKPNHKYPRYPKDPRKNQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8Z1</accession>
    <name>A0A8G1R8Z1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_392692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518594.1">
        <property type="nucleotide sequence ID" value="XM_025656853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8Z1"/>
    <dbReference type="GeneID" id="37160255"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF24">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH60672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="514" mass="58541" checksum="3579CCD1AB14F272" modified="2022-01-19" version="1">MDDTTFGETPRKRARTTSLQEQPEPVPADNSSESPAWDQLQSPYHLADYYTDQHNSPTLPIGSDPFQSPAASWTQDGFSQDPGYLASQEELRCILFSLANSTAPTRVSSPDVVGRFELAEQSPPSNKYQPERRGELLQSSLSSRRRIEYLKNYVAEVAPWLDMFDSQCTFRQQVPVLARSFPALSYAMLAISARQIERKNGVRNWFDSLELYQEAIRRLSPLLQLRDPKIVAACVLLCCLEMMSARAQDWRRHLEGCAALFDAFGIHGFSQGILQAVFWCYARMADLCGALISDGTQTTLLHPSKWLPEGYQTEDAHQLFQSVKSPDMHANYAVYLCVKATELVSDRTKFVELGEDNGCTPDRFRTRWISLWNDLQCWFSERPSELLPVQTVNRKPFPHILFVHWAAISSNQLYHTACILLLKMMPKDIRLPRSPTLFPLWHARRICGISLANPHQGCLNNSIQPLWIAGQLFSHVSEHEEIIRLIQSIEAETGWGTCWRIRDLEVAWGCSGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R956</accession>
    <name>A0A8G1R956_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_448025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516972.1">
        <property type="nucleotide sequence ID" value="XM_025659842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R956"/>
    <dbReference type="GeneID" id="37163244"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF9">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="250"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="539"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="581"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH59050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="709" mass="79085" checksum="D5506862CCB851DD" modified="2022-01-19" version="1">MVSPSSFGSRLEENETDWHAAPRAAKRRKRASTAGASRPSPREIGVMRESQNDGPATFLGSSSGIHFVRQVYNAFARRSAELQRARNRTSVPGEDDRLQRNSGDFNSHITDELWSREELKFESNSSFSFDDLASWTRRYFEDWHPIFPFLHAPTVLKSMEALANQGVSAVSRLDMIIIRSLVSISLADNRQTDGSGANTEPVPATLVFQSVRHIIEDIQSLLMEPTTVPLLQATFCAQLTLTSLLRLNAASRVGGVITRTAYHLGLHRCPARFSCFGSHEKDIRYRLFWSIYTLERYLSQALGIPLSIRDDDIDVCYPGEERHSTTPLTSHGHSDSRLRLLCHLAKFARVRGLIIELRNKSVLHSHASPVEASYVNGELSQWWNEVYDDVYPTEDDEDTESRQGSPLASYHRLLLIVFRHEAVIAMNRPLLTAEKPNQDQDYKNALQTCIESSRSALAALKRYMSSPSHAPMTWPSFTWTTWMACLILMYASWEGELPIDTALKYGRMGTSVLQNLALRGSSWPETCIEGIKSMVSALSMNQSSRDHENAAGPLSDGNASQLVPSDTRGAMRPESQHRSHPSASMGMNSAFSNTHRTGPTMYHRLSPSMSPQPFEPSTDSAPRRVNPIEHCDSPNLIRNASDMIDINSNDASHTQTSAGLIFGNMANSNAVLNQGLGQDPLSFSDPSYLFMNDLWSVADGPWIIHGNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9Y7</accession>
    <name>A0A8G1R9Y7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_414715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519213.1">
        <property type="nucleotide sequence ID" value="XM_025657657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9Y7"/>
    <dbReference type="GeneID" id="37161059"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03078">
        <property type="entry name" value="GST_N_Metaxin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021211">
        <property type="entry name" value="SAM35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF44">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN (SAM35), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10806">
        <property type="entry name" value="SAM35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="2">
        <location>
            <begin position="80"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="1">
        <location>
            <begin position="227"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="297" mass="33842" checksum="FCF8BBE27F68B0FF" modified="2022-01-19" version="1">MTPEHRDVPGQTPDNVSTVSRARDFFSVPAPIKRIFDRFPLVTYPSNDLPHSAWSDKRGNRLYVFTDAASARHGRPSFNPQCLKWQAYLRFVGIDVDVIPSNNHASPSGALPFLIPAHPINNNAPIPSSKLQKWAIEQVHCEEEQQLDLRFEVYASLLDHRIRNAWLYTLYLDPEEFEAVARPLYVDPSSTNSAVRTALALQLQQAARTEILKTSSYIDVGALEAEANDAFEALSTLLGDNLHFFDRPNPGLFDASVFAYTHLILEEKLGWQRNRLGQLLRQHENLVQHRDRLLKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAB0</accession>
    <name>A0A8G1RAB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metallothionein-I gene transcription activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_445620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520115.1">
        <property type="nucleotide sequence ID" value="XM_025659307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAB0"/>
    <dbReference type="GeneID" id="37162709"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.30:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH62193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10465" checksum="0650895884AA7996" modified="2022-01-19" version="1">MSREQYQVPNLGGGAQNAFGDAAGGGPMDGPVVAYLCGECNSRVSLKRGDQIRCKECGHRVLYKERTKRLVFPSPFFFFFFLPWGWGWGEDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAB6</accession>
    <name>A0A8G1RAB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_435089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520421.1">
        <property type="nucleotide sequence ID" value="XM_025658500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAB6"/>
    <dbReference type="GeneID" id="37161902"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015:SF1">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="887" mass="102746" checksum="44AD51AA11EBA272" modified="2022-01-19" version="1">MAPAVSALSQTLRSLTESKIRELEKRRKSYEADKAAILEAARATQDTRQRLEHLLKGARELCPSASSDPTMVNIERWLHQSIYDSSIPPEKLQEFEAQLLRKLNIQSRKLGLADLYSRLLTEWVDPPVAAAQDESEMAVDDDYMVVDERQKQRLQQLCDQFDASVFEPLETNEWQIRAFLDDLFPDEESVNALVNLRRQLKGETTSFWEEQEPFTARSVEYCVRGLLNEELLSEEKREIMNSFLKTPVALTEIADVLNMRYSDIENWAWHAGENGIPVVPRQQANGKYRIWMDEDLLQLIFLQYIGTRHCNILKRLLSSFVQQDSVWNRKPERQMTARDRLRRKYYMGNGEVYSTAEQLRFTEYLKTYFLSQLPKSERTLSEKGNSYDDDNEDAGTNPTRHEGKNLRQQLLRKIATEALVRRHLHGAAVVVQSDMRWYATCLPHSTIVIIMKYIGFPKRWIDFYHRYLEAPLNMDSSYEGREPVGPRVRKRGIPFSHAAEKLLGEMILFFMDLAVNRETGLLLYRLHDDLWLCGEPAKCVRAWEVMGNFAKATGLEFNYSKTGSAYLAEYRDPRIAAQLPEGSVTFGFLKLDADTETWVIDETLVDTHVQQLKQQLDRCDSVISWVRTWNSCIGRFFKNTFGQPAYCFGEPHVRAILTTYKKIQDRILNDSASTSIPEHLRAIITGRLGEFEIPDAFFFFPEELGGLGLRNPFTSVLLVEGIMGEPPLARVKQYLEEEKTFYSQRKKKFEDLSDQRRQKMLETCVSNADLDGDLVTEREIHTFMSFEEFSRFRETASGNLRRMYIELMRVPTMQPLDASPELERALRETLTQGQVGNLDSEELWHLQLYAGEVLEKLGGLRLVDQKFLPVGVLGMVKETRVKWQMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAQ3</accession>
    <name>A0A8G1RAQ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_500873</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="4"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519509.1">
        <property type="nucleotide sequence ID" value="XM_025664139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAQ3"/>
    <dbReference type="GeneID" id="37167541"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH61587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="359" mass="41249" checksum="8FB51D47D7F4278C" modified="2022-01-19" version="1">MAVTRVQQSVSSPTVKAPRRDTSLSIRLPEMFVLFLSGEPTVNRHYKYHRHNRECYFDERSQRRLQKTDFAYFCSIAAPDAEPEELRTVIDWGNWVFPFDDLFDNGSLKDDPERAQVLVEDLRAGMADETGQRPVLSDYPIVQVHNSVWHRITQAQPIGIRRRFARAMNDYCTGCMAQVRSCSKGELPSLEEMLSLRRQSAGVSPLFALVEYAHKLDIPDHVFECKSIQEIERIGTDIVLLQNDILSYCKEEKEGVSHNLVAICRHNGMPAQVAFNHAGEMLIERYRDWYLALAALPTWGERIDADVQEYIRGVQNVVRANLHWSFRSGRYFGKANDQVRKTGYVTVRSNNADFKLSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAV9</accession>
    <name>A0A8G1RAV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_473470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520706.1">
        <property type="nucleotide sequence ID" value="XM_025662624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAV9"/>
    <dbReference type="GeneID" id="37166026"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00531">
        <property type="entry name" value="NTF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="144" mass="16391" checksum="18334083247B7999" modified="2022-01-19" version="1">MSNTNQTLHAAKSWLQDFHSLGDQLNPDTAVPKFYTPDCEMRFPGHAPIKGDEAIISFFKEQSTILESMKHTIGHVDVLPDRIYQEATIDYVLKGDEEKKVVSVQGMAIFGKRVDEDKMRFFTVYLDTSPLVERVRVVTGAREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB77</accession>
    <name>A0A8G1RB77_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="3 14">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO85DRAFT_219018</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="3 14"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518007.1">
        <property type="nucleotide sequence ID" value="XM_025654672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB77"/>
    <dbReference type="GeneID" id="37158074"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000001">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="18">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="19">
        <location>
            <begin position="142"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RAH60085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="292" mass="34089" checksum="74232C701E9C6FEE" modified="2022-01-19" version="1">MANSKYEYVKSFEQPDVLLPNTWIVVRIDGRGFHKLSDYYGFIKPNDRRALDLMNAAAVGVMKDLPDLCIAYGISDEYSFAFHPNCQLFERRSAKLVTTIVSTFTAHYIYLWGTYFPDTPLQPAALPSFDGRAVMYPNSRIFRDYMSWRQVDCHINNLYNTTFWSMVLQGGMDRREAELELKGTLSSDKNEILFKRFGINYNNEEEIYKKGSVLYRQYQLEEKSDSSVQEETSPLQEDMPSKTQQEKIRKLRRKVQVVVDHVDIIKDEFWERRPWILSGKPGKLPTEAKEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBJ5</accession>
    <name>A0A8G1RBJ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Pectinesterase</fullName>
            <ecNumber evidence="5 13">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_516302</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Involved in maceration and soft-rotting of plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="5 13"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519631.1">
        <property type="nucleotide sequence ID" value="XM_025664838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBJ5"/>
    <dbReference type="SMR" id="A0A8G1RBJ5"/>
    <dbReference type="GeneID" id="37168240"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000014">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018040">
        <property type="entry name" value="Pectinesterase_Tyr_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF127">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00800">
        <property type="entry name" value="PECTINESTERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="10 13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034802310" description="Pectinesterase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="14">
        <location>
            <begin position="28"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH61709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="331" mass="35714" checksum="25B529F2026C797A" modified="2022-01-19" version="1">MVKSILASVLFAATALAASRMTAPSGAIVVAKSGGDYDTISAAVDALSTTSTETQTIFIEEGSYDEQVYIPALSGKLIVYGQTEDTTTYTSNLVNITHAIALADVDNDDETATLRNYAEGSAIYNLNIANTCGQACHQALAVSAYASEQGYYACQFTGYQDTLLAETGYQVYAGTYIEGAVDFIFGQHARAWFHECDIRVLEGPSSASITANGRSSESDDSYYVIHKSTVAAADGNDVSSGTYYLGRPWSQYARVCFQKTSMTDVINHLGWTEWSTSTPNTENVTFVEYGNTGTGAKGPRANFSSELTEPITISWLLGSDWEDWVDTSYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC94</accession>
    <name>A0A8G1RC94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_445489</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519991.1">
        <property type="nucleotide sequence ID" value="XM_025659273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC94"/>
    <dbReference type="GeneID" id="37162675"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH62069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="448" mass="50220" checksum="255604BD521B72DE" modified="2022-01-19" version="1">MREVISLNVGQAGCQIANSCWELYCLEHGIQADGYLTEERKKDDPDHGFSTFFSETGQGKYVPRTIYCDLEPNVVDEVRTGTYRSLFHPENMITGKEDASNNYARGHYTVGKEMIDQVLDKVRRVADNCAGLQGFLVFHSFGGGTGSGFGALLMERLSVDYGKKSKLEFCVYPAPQNATSVVEPYNSILTTHTTLEHSDCSFMVDNEAIYDICRRNLGIERPSYENLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVAYAPVISADKASHESNSVSEITMSCFEPNNQMVKCDPRNGKYMATCLLYRGDVVPKETHAAVATLKTKRTIQFVDWCPTGFKIGICYQPPQQVPNGDLANLKRAVCMLSNTTAISEAWSALDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVASDSLEEEVEAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCF1</accession>
    <name>A0A8G1RCF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_18245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521029.1">
        <property type="nucleotide sequence ID" value="XM_025654355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCF1"/>
    <dbReference type="GeneID" id="37157757"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="239" mass="27014" checksum="0F1FFFE6FDB4C6FE" modified="2022-01-19" version="1">MPDMCCSDDALYASGGKGSMRYLFLHGGHSQLPPPDNFSVEAKVLVQNTHGEIIFDDSPDQPTSQYQFIDRTLKSVNGKDDAYIPKQLFVEKMLMNVSIPTLLFAEIPRDHADTPSSENVSYVTLLILGRTGVEQASFQDYEYLKSMLHLFVPRFGRAISRMSDVYLPGDALNLSHEVAGYMMVPSGDTNNLRTFLAMYAKRYMLKSSSEREVLERCLLHMLKMPFELSSAIRYGLILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCY3</accession>
    <name>A0A8G1RCY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_135413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520351.1">
        <property type="nucleotide sequence ID" value="XM_025654035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCY3"/>
    <dbReference type="GeneID" id="37157437"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="141" mass="15545" checksum="E9ABE4487EF7EAB5" modified="2022-01-19" version="1">MSGGPSLVFWCARSTSYNRLSVSLLHSTYPLWPTSLCSIGSCVDSASFFLTFLLVQVSNPTRPCLLTRPSCRGPFHPLIDPSCCLWLFLPPLTSSSSSSSSSSSSCLFLPQPQAISLPRLWAFAFIVPLLCKAHRLNFLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCY6</accession>
    <name>A0A8G1RCY6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_364484</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of several multiprotein Golgi SNARE complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GOSR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518907.1">
        <property type="nucleotide sequence ID" value="XM_025655700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCY6"/>
    <dbReference type="GeneID" id="37159102"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="47"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR027109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH60985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="227" mass="25680" checksum="D80823DBB90CD623" modified="2022-01-19" version="1">MATSTGTGWAQLRQQARSLETQTENLFHTYSQYASLTKLPPTPSEEEQRIESQLKDLLERRDSLISQLARLLDSEATLTSSALKQNNLSRHREVLHDHRRELQRLKSAIAESRDRANLLSNVRSDIDAYRNSNPGQAEADYMLEERGRIDESHNMIDGVLSQAYAINENFGLQRETLASINRRIVGAANSVPGMNALIGKIGSKRRRDALILGAFIGFCFLMLLWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDB5</accession>
    <name>A0A8G1RDB5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_386081</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520546.1">
        <property type="nucleotide sequence ID" value="XM_025656620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDB5"/>
    <dbReference type="GeneID" id="37160022"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF199">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH62624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="500" mass="56752" checksum="6FF0835E426DB78E" modified="2022-01-19" version="1">MAVNLLSIGISLLVIYPISRIIYNVFFSPLSHLPGPISWSATRLPFIRALLRGTIVHDFERLHRKYGPVVRTAPDEVSFASGDAWTDIYASRPDDRQFLKDPLWWRRQPGQPDTLLSAIHPTKHSRMRKLLAPAFTPRALRVQEAVLQRYASLLVDRIRDQVSAAGTDGAVIDMGPWFNFTTFDIFGDLGFGESFECLQHSRYHPWIALLFGSVKAASFIAAARYYPPLEALLMKCIPRSLHEKSQRHYRQIVDKIDRRLSWELQRPDIMSHLIDENGQVALPRGELNSTFMILTTTGSETTATVLTGILAYLVNEPQIQERLIREIRERFELSQDISLSAAADLSYLTAVIQEGLRLCPPVPWMLPRQVPPGGSTVCGTWLPGGTPVSLQAYTLNRDPSRFHAASSFVPERWLADALNNPNSPFYHDDRQAVQPFSMGPRACLGQHLAWAEMRLILTKLLVSFDFEAEEGKHLQWEELRTFLLVEKRPLEVRVRLAPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDH0</accession>
    <name>A0A8G1RDH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_465454</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521599.1">
        <property type="nucleotide sequence ID" value="XM_025662055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDH0"/>
    <dbReference type="GeneID" id="37165457"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH63677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="653" mass="73123" checksum="5B8C91A3A3EEB290" modified="2022-01-19" version="1">MKENGSSSGRPYRSHAHPACLPCRKRKSRCRTRDSSATCMMCLAHATECLFPSADKPAQRKRTVNLQRIAPKTARVERPCTPQVVLPSPRTSQRSDTPQLTRHHHLAHIPTAYSDGRIASLMDVVGDTGDDSSHVVSPVVADDSSILEGYLFTVSDNRRPGLIHTSSKSSRLMRQVLFNTIPRRPLGVYSNQSLPSMKCELIEKYLEPATKDVVGLFFKCANICFPVFDEASFMNAYCTREEEVSPALLCNLYANSLIYWDNSPQLRSTRTPDIRYIWNQANEALHSELFLCPGISTVLAMLLNVCGRPSTSIFGNGGMVGTAVALSNALGLNRDPSQWNISALEKGFRIRVWWLVVIHDRWCSLAYGTPLQIHRAQYDVPFPTMEYLISSPGMPFHEAAASIFIAFTTLTEVLGQYLEYIYHVSSPVRKTINSLSHLLTNWEESLDTKTRHIIRRGTNLTTPGAANLRLAYLSVKLLLRRIALDLDDGQTEISNNDERNDGTSSSISFTQVERVAEEIVHLVRELDELQLRGFWIPVQAYSLTSATTFLLRSGLRRVKSHSVESGKNSPLELAKEMIATLQSHRLRFGWDLGDDCLSKCSELVKRIASVDNDGTGLPLSDELSDSFQPFDIETSILDDLFWDMPCMGNTFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RFM6</accession>
    <name>A0A8G1RFM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_483376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521462.1">
        <property type="nucleotide sequence ID" value="XM_025663156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RFM6"/>
    <dbReference type="GeneID" id="37166558"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="418" mass="45302" checksum="4F14A96BEC2C8360" modified="2022-01-19" version="1">MVVWPFEPRLFDLIEHRLQIHQNHIVDTGLRSWSKLGDPASEAAAGSSANSAEGQTSGSQLLSSHFRNHANDLTIVGALSAEGKVLGDSYSRLKTLATDFSSLSIEEVLRHLAGIFVGILVHGVLSSARVVVDALIDFIQSFTDEAMSLLDTKLHIPVVTDTLNLLGIPDISFLDLFMWMGAVAYTVVYKVINNEPHFPDDGNFAALIAASSWDELKQSLSSSPASPRALFPTAQQSIYACANTMSRMILFIGNIALFMEAQAPTAAWWPSNVLSPKDPIQDFGMKVLSRFCFGLDIATSFLGFTPVYGKLVAITSRFPYLLPSDGRAVGAVFKALLLISKLMATSYHLYELTSEEAGAARSAAIVGEVANLTGAVVTVSYAAEMNDKELASRQVPIRVMTLCVDLWSDLLVAESMIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGV7</accession>
    <name>A0A8G1VGV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_454352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825089">
        <property type="protein sequence ID" value="RAH52010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509932.1">
        <property type="nucleotide sequence ID" value="XM_025661266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGV7"/>
    <dbReference type="GeneID" id="37164668"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="244" mass="27942" checksum="2241EE18B84C214C" modified="2022-01-19" version="1">MATESPASHLTAEMLVTLEMFKDSPWEEPVPVSPFWDSIDYSIARNFLGSFTHAERAQLPIDEDSTADQQSKLILLLRLLQKKLDEEEAATSPPSSLYTSNYHQWYRLWQGIYVLQDELNLPEAEQTVRMLVDKTPYKSNPVPSHMLAEHLVKVGKYEEAERTKRPIRAWMDARPHLGPSSPQALNARRLIAQALWGQGPSRRSEAEALIAEIHWIVEEMGEGQFAVYQAEERRLNQVMMATLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VH39</accession>
    <name>A0A8G1VH39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_453645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510908.1">
        <property type="nucleotide sequence ID" value="XM_025661098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VH39"/>
    <dbReference type="GeneID" id="37164500"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09999">
        <property type="entry name" value="Arginase-like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH52986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="297" mass="32871" checksum="61BEA48AC6EC301B" modified="2022-01-19" version="1">MPANAITIIFSPYHVGIRDHRVGNGPHRIRQHGIIQALEGLGVEVNLIELEPVDKFEGEIGRSFELLRRTSTTVTQAVENNTFPIILSGNCMASAAVACGLNTNNLKFIYFDAHDDLDSPDVNENGYLDAMGLSMLRGESWKTLMRTVPGFKPFTYDGNFLYCGLRDQSDVQRQRVIDAGMSAIWGDSDRKVDFVGELRRELDLKSYGPALVHLDLDVLDETYGKVNDYPSPGGLFERDLLGCMELVPTRSTPMSLTVCSFDPDVGDGDRIAKIAVRAVTAFIRSLLDTGVILRQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHX6</accession>
    <name>A0A8G1VHX6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_405414</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511718.1">
        <property type="nucleotide sequence ID" value="XM_025657299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHX6"/>
    <dbReference type="GeneID" id="37160701"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="292"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH53796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="601" mass="66648" checksum="2A2E835D1B0EB8A8" modified="2022-01-19" version="1">MINHLEGSLERMESRLQGLGFTVGENDTIIGLSSSEGVGDISPLRLSLSPTDRSPQVEDVDDTDWGNIYTSPPPGPNRSSASRSPSPHMQNLSGQSSQPQAAVPCFNVPRYLGGILNSGCFSMISQEGLEWIAQKTGGESMDHLTRLVLAEERDGFIADYPLHCISPRRVFCPLPPQEHIIRLVERYLEDFNVIFPLFRRSDLLLLFERAHLDMRFQSPGQWAIMNAILAVAYMLPDNGASKQPDHQKSWLLLKNALEAVNELYLGPPDLRGLQGLLVMVVLFMAASAARPCSFLISVAIHISDQLGLGTTEDISIFTEEEKQERQTVFWLAYCLDREISFRFGEPPVQNDEAISAALPLDAPNCLVYSMPTNDRAGTFSAFASACRLAQIRGEIYQRLYSASATDRPFHQILASVGELDRKLQAWKDSLPSEFQPESPTLFHSPPVSLILLHMHHTYHNCMIAIHSLIAARGINSAQDLSDHPGYTINPDSLSNPRVLLSASLTSKAARASIGLMKYLPKDDISLGLTMYFPTVALRTLASSIVRNPRDTGQIYNMRILDQAEAFLSSTCSDSTSEGMKRLVKNCAEFRSLAERAMKECY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VID1</accession>
    <name>A0A8G1VID1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_481454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511059.1">
        <property type="nucleotide sequence ID" value="XM_025663061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VID1"/>
    <dbReference type="GeneID" id="37166463"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="LIPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="235" mass="25724" checksum="79BBA53F00C77BC4" modified="2022-01-19" version="1">MSQATHQALGEKYAARDLMTDTRDKGLQAQLSNIYRDILGQADSNQISLWIALRFILNIRYSGVDTADPYTALTTSVRQEVNELVEDIDKIIQNAIPDANNRRGSMDIAYADVDARFEGHRWCEAGVKEPDATNPSTFFFLSGWSDITEEGAIQQAFSSDDESDYISSLQGQTTLTLPDGRTCNTTMGANPDPVDVYWCQVAAAAVNDTDGALEQMASRASSEVADGNYTTQDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIM3</accession>
    <name>A0A8G1VIM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_503980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511732.1">
        <property type="nucleotide sequence ID" value="XM_025664272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIM3"/>
    <dbReference type="GeneID" id="37167674"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH53810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="255" mass="28301" checksum="F47D799D99400E5D" modified="2022-01-19" version="1" fragment="single">EQHLRDKIHTPVRKTRKGLLCDKCDRGFSSKAALMQHQRSLVHRPLSNLECIVSKCQKRFKSPSALLHHLESGTCRSSMNREKLNDIIRLHDTNHVISGQAQPSRIYALDETLSVSSDYSTRFQVIYTPSSAASVSSLYLAEPSPPGAHVFDLKTVDSGRKSCLDCSRTFKSVQSLMQHRQSAAHTSAIFSCPTALLSREPALKQSFSTLSGLAQHLEAGACIGGYSMLQEAARYLETCLHNMGFKRKILLNSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ01</accession>
    <name>A0A8G1VJ01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_92011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513006.1">
        <property type="nucleotide sequence ID" value="XM_025665791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ01"/>
    <dbReference type="GeneID" id="37169193"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH55084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="124" mass="13995" checksum="8F3ED70EF1DB2420" modified="2022-01-19" version="1">MTASPHAWANIRLSLYGLMRQRCNSLTVFVSITVIAADGVSDFGCTLANRSLSKTLVWADLFTPGRFWSGKLSVLYSVFVGDLLMLGCPMGQARCLMDMITFMKLYVFSRLYRPLCKCFPDNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJN2</accession>
    <name>A0A8G1VJN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_66563</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="14">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513741.1">
        <property type="nucleotide sequence ID" value="XM_025665576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJN2"/>
    <dbReference type="GeneID" id="37168978"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23791">
        <property type="entry name" value="UBCc_UBE2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000068">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-20 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="16">
        <location>
            <begin position="32"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="13">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH55819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="181" mass="20193" checksum="E88688CA93269E5D" modified="2022-01-19" version="1">MDYSMEDTQNSAPDAHEASKLNSSAQRTDIQSVTKRLQAELMQLMLSPSPGISAFPDADGNLLSWTATISGPAETPYEGLTFRLSFAFPNNYPYAPPTVLFKTPIYHPNVDFSGRICLDILKDKWSAVYNVQSVLLSLQSLLGEPNNASPLNAQAAELWDTDQEEYKKHVMARHRDIEDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJW2</accession>
    <name>A0A8G1VJW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_451989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513007.1">
        <property type="nucleotide sequence ID" value="XM_025660718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJW2"/>
    <dbReference type="GeneID" id="37164120"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="63" mass="6917" checksum="14321864548F21CE" modified="2022-01-19" version="1">MSSPPDSHNHTPLHDQDPSPSSAPDSTPNNNNPLLRTTNPLVSSLEQEVLDEYTRLLGNVNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK35</accession>
    <name>A0A8G1VK35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_451612</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513217.1">
        <property type="nucleotide sequence ID" value="XM_025660627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK35"/>
    <dbReference type="GeneID" id="37164029"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="16"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH55295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="357" mass="37520" checksum="EDB67EBADCC6D2AB" modified="2022-01-19" version="1">MSLPSTYLAATVPTPQSPTTLTTKPLPTPSTNQVLIKITATAVNPVDWKMRDYNFFLTEYPAILGSDASGTIAAVGPNVSTFTPGDRVFFQGIIGNYAASTFQQYCVMPAELVSKTPSNISDEQAAGISLASVAVVTGMYDSTGHGITPAPWAEGGSEAGKGKAIAILGGASSVGQYAIQFARLSGFTKIITNASVVHKEHLEGLGAHVVLDRKVAKAQNFVDAAGEVPICYVYDAISMKETQVLGVEIAKKSKDNAKAVVTVLGAEKEAEELGKEGEHQVEIRPILGIGASPKLRHISEPMVKALGGEDGWIAKGLFVPNRVRVVPGGLEAVEEALKTNKEGVSGEKVVFRPNESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKG8</accession>
    <name>A0A8G1VKG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinetochore protein Sos7 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_79536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513592.1">
        <property type="nucleotide sequence ID" value="XM_025665669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKG8"/>
    <dbReference type="GeneID" id="37169071"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
        <property type="entry name" value="Sos7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="3">
        <location>
            <begin position="75"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH55670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="287" mass="32112" checksum="08BE709C2B83FDD4" modified="2022-01-19" version="1">MASLTPAEARKQLQQLTDDNGDLKTQLNILRISEPIFSPDSDTRRSSPSKRRSDVSTFETPTPASLEADLTHYKELFSKLRFSYVEQVTKEKFLRAIVGDPPLVVGHNENVEMEAQLAEVKADLKARKEEVRTMVEEMEKLGRDLANRYKNVQLQMTQLSTLPESIGNLESTVAELRAKQGSDANGPESQNLPLPATLSLLSEREAELAALDRQLAAVQNTLPRKTREAEAVERELGVLERRKTEAIAQAQEVKRKKEEGESDGLVETGRWYRSAEETLKNLLGVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKP2</accession>
    <name>A0A8G1VKP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_422635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514673.1">
        <property type="nucleotide sequence ID" value="XM_025657978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKP2"/>
    <dbReference type="GeneID" id="37161380"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF3">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="308" mass="32996" checksum="DFFB8B68B9A66DF9" modified="2022-01-19" version="1">MRIARPSFNPGRTKNLIHGFQGFIIFLAWALTIAVFTKGGGIDGRSAWYFALCWFSIPGLIYLVAVPMWPRARRFGNVYAFATVDCLYAILWFSAWVCVASYVAEGKSKGSSDSSSDSSSSSSSSSSSSSRRDTSSSSSSSKSGCDNWAYGSASKCKVSTATVILGVVVFLLFCVTAFMSFRNVSHFRRTGTLPDAVSDPTFAAQTKAAFSSNPAHDFEEEEDDFRSRAGIGSSVRGDRDEDYALLQQSEVDEFGNSHAARSALSGTYDPTVSGGSVLHDYNTSYGGAHGQHYGGASEFGSSVSGYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL24</accession>
    <name>A0A8G1VL24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-antigen, N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_489690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514222.1">
        <property type="nucleotide sequence ID" value="XM_025663620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL24"/>
    <dbReference type="GeneID" id="37167022"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024391">
        <property type="entry name" value="LDB19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF76">
        <property type="entry name" value="PROTEIN LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13002">
        <property type="entry name" value="LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LDB19 N-terminal" evidence="2">
        <location>
            <begin position="154"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="534" mass="59442" checksum="EB2E5F39E61BBA6A" modified="2022-01-19" version="1">MPGRLLSSFVRPSLSHHHHSSHHSSVSHSNSSSSSSVNEIPPNTVVSKKPSTHGAERARSPERRLSFAVEHLIHPHRDHSKDKRRSHGRSSRSKERAGQEEIANAHAKLDVIVESPPLVCYGSPANSTGALFSGRLKISISELAGMVTLDTFDMRLMSRLTTKKPVSRDCANCASRTEELTHWNFLTEPLHLKNGDHEFPFSYLFPGHLPASCNGSLGQVEYFLSARAHNVNGEEYTYEMPVHIKRAILPGNDKSSIRIFPPTNLTGRIVLPSVVHPIGTFPVQMTLSGIVDKKEDTQTRWRLRKMMWRIEEHQKIVSTACTKHAHKIGGEGKGVLHQETRIIGHNEEKEGWKTDFDTAGGEISMQFEANINPSCNPVCDLETPGGLEARHNLVIELIVAEEFCPNRNPKLITPTGAARVLRMQFHLHVTERSGLGISWDEEMPPVYEDVPASPPGYTMLDGDSIMEDYHGSPIHLPEYEQLERMDSLRLDSDSTHSSIRGRSRLTTDDLTAEPTVPAASNRAPSVDSQSSRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL25</accession>
    <name>A0A8G1VL25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Galactose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_514073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515286.1">
        <property type="nucleotide sequence ID" value="XM_025664739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL25"/>
    <dbReference type="GeneID" id="37168141"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF24">
        <property type="entry name" value="GALACTOSE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034694286" evidence="1">
        <location>
            <begin position="22"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="243" mass="26009" checksum="109ED91B57629359" modified="2022-01-19" version="1">MRYATTVIALAASGLLGSVDAASSRSSDRWVNLASIPTPRQEHGTVAIGNSTIAIVGGIAPQDNGTTTVTTDLVQLYDITSNTWRTGSASPFKVNHPNLASVDPKKLYLLGGLTDVPPPKGQDLDMNWIASKDCYVYDAATDTWVEIVSMPNGTERGSSIVGVHNEMIYLAGGMTVLQTGYQDAVDSVISFNTTSGLWQRLESAAAELPASRQHATGSVIGDSLYVIDGRRYGQMYHQHSFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLA1</accession>
    <name>A0A8G1VLA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_449388</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515318.1">
        <property type="nucleotide sequence ID" value="XM_025660154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLA1"/>
    <dbReference type="GeneID" id="37163556"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14670)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH57396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="495" mass="54785" checksum="B9CA78D288C66027" modified="2022-01-19" version="1">MSKPTEEYTEYHEDTAKIQESTQDAIYQTYVAKSPEWHRKMTKQLLRKVDIHLLPFLVVMYLLNFLDRNNLSQARLGSLEQDLGMKGTDYNLATSILFVGYLLMQLPSNLLLTRVRPSLFLGTSMAIWGVISACQAATQSFTGLVLARFFLGFVEAPFFPGAIMLMSSWYTRQELSHRIAWFYAGSSLANAFGGLIGAGVLGNLDGAHGIAGWRWLFIIEGCITVGISLTSTLLLPNYPATTSWLDETEKLYAQWRLIHDAGEADEATSSNIKEALYLVFSDKRIYLFILLQHTSLLSQNFQYFFPTIVETLGYGNIETLLITAPVWIATFFVSLFVTWTSGKTNDRGIHIILLMLVSVVGCIICTATTNIGARFFGMFLMPMGAVSAYQIIIAWVANSFPRPLVKRSAAIATANMIGNTASIYGSYMWPSSSGPRYIAGGSATAGIALLVAIIAFVIRVVHLRVNKALDAAEQDRGGVEVDNLEARNAGFRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLE4</accession>
    <name>A0A8G1VLE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(II)2Cys6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_469058</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515646.1">
        <property type="nucleotide sequence ID" value="XM_025662310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLE4"/>
    <dbReference type="GeneID" id="37165712"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH57724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="71335" checksum="132E27AD9B25F0A1" modified="2022-01-19" version="1">MAPKRTSSSLTHQTALPAERDASSAMTVSRPACGAPSLLASAAPPAADREPTRAHSSPKGTGRQEIRAEDNRASNPYAVEKNSPRPQEHHSNVAAALTSHPTAPAIPEAAVPLHPDGSIESPHFDPLHEHNEQRLPSLDPAFPTSPVSLSQISLLNISPFEWYDLLARDAINHIQRLNDTSSGDPRWRFPEIALSRRQSPTPEHPGARLQQEARYNEQQGHPLTHGDGHTGSPLPDYQQLSQPWNTTSRLELSPTDLTFFQYYIEVVGPILDLFDPAHHFSNVVPHLALRNTGLLKSILAVGAKHMSLCLQHRGDGDAADGHVAGSPASLPGTVLSTESDSAPTHMATQYYYETLHYLSQTLLYPSYADSHEILATATMISTYEMFDADSAANSSVWEQHLRGSFWIQRSQDNDGESADGLRQAVWWAWLRQDIWAAFQAGRPTITFWRARKPLEELSSDELATRIVYLCGKCVKYAASAAIPPHQDPRERIEQGDRLRSALDEWYHILPASYQPVAVAGGGGSSVVFPPIWIHPRNHAGAMQMYHFAKATVLLNQPTLGGLNAYLLRDKQLTESVKMVCGIANSCQEHDCAMAFINVQALFGVGQFVRSPEMREELLRILDNMLRISKFPAKGLVARLQRVWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLQ5</accession>
    <name>A0A8G1VLQ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C6 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_449157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515976.1">
        <property type="nucleotide sequence ID" value="XM_025660101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLQ5"/>
    <dbReference type="GeneID" id="37163503"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="287"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH58054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="760" mass="85417" checksum="5539C975BDBD53C1" modified="2022-01-19" version="1">MSNVDLSSDGFIGLDYDSRNYLQAHSWPVAVDHQASQRSDGARDISPLQTSGHAYDQSVAQDPNLMVDWHFQHLQPHLQYSHEEASSAPQQFTTAASYGMSIHSSPVDLMSGAHGHMSTSLLDGSYLPLSAPVDMVPFPYHDLQADLMAFPPADGLPDLSAYSAPQNVLESSSPTDTYLEVRSLSSSDNGWSTIEPRRSHEFSYPDQGIFINPTQTLHDRSLSESSYSTSYGSFVEITNPINSPSSDTNFDTAFNHSMTRRVSYDHTSHGSQSPTAVSPVAIVRPIPVPSKKASTPPTRSAGSTSSASPPSRKPSRKSPIAAKTAETKVRKQSQNGKPETEKRVGKRKGPLKPDQRKQASEIRKLRACLRCKFLKKTCDKGEPCAGCQPSHARLWQVPCTRIDIKEIGYFMKDWKADYDRHVNYDFTVGNIKGFSELETTLFITHGYGQVLPINAREVYVHDDQCFKVDWVESMHREPTPYEVETARLSAGMEGISHAMLSDYLDRHIDGNGTFEKFVDDYFEGTPFLTQMLKTAFRYYYRTKLPVIRKALKLIIAYNLTLHVTMVEGIGEEEQFKGKINDKSSKFSGKTIAPVMVNFQVKCAMANMWRELQKDVLEELSSLYSSVYSGEKLKNWPTIFILASILLAVWEEMQFDCHYRTPDAAAVDKFCNDMETTPVGVIVGLFQAISQKLPAFTDWETTKHHHLLHSNPDVCNTMTEVRQHVTQFESYLRGRNGSKFNRNDFDCLSNKFVSRLVIRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLW8</accession>
    <name>A0A8G1VLW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_43832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514809.1">
        <property type="nucleotide sequence ID" value="XM_025658663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLW8"/>
    <dbReference type="GeneID" id="37162065"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH56887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="128" mass="14430" checksum="7941992777103C68" modified="2022-01-19" version="1">MNVEKPSDCLDGMSRKYVVKSSRAVWPYNSIPANSDQLKPSKIQALKSSLRELSLSDTGTTYDYLLPPSRQIALKPCNNSMKTANAPLSDNARKKEKMVVHQDTHVLRSLRINLVRGTLCTTYYLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM16</accession>
    <name>A0A8G1VM16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_470591</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513190.1">
        <property type="nucleotide sequence ID" value="XM_025662411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VM16"/>
    <dbReference type="GeneID" id="37165813"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="580"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH55268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="729" mass="83670" checksum="F019F5D0B7A0B525" modified="2022-01-19" version="1">MYQANPELHELITSGAFVQSQSAVPLRAWKDELGRLRLWAGNIGAHQTGQSSLDYRLRDASHIKNQTVRILEAIRKLLAELRNSLSGEKEDVEDDQLDEDLQSLIAELNLDNPSDSILTVSDAHESLVNKISQLFDISMTVRKPAQQDRLIGTEKSDAEPFKFNFHQHVSHKYPQAENQLTERISSAMARQRAILKYRERHHLKLNQGLNIGADDNTTVQLSETVASAFKLETPGQKPDDLMSNSDASFTSYAGSLLSGGEKLAIPAFPREAAERRPFECPYCYYIITLKDRQAWARHIFRDLSPYICIFSGCPTQNKLYESRKAWYRHIRQTHMASQDVRGSYACPLCAEDLLPMASFEKHVGRHLEELSLFVLPRGTEDDEVLDDESGNDESGNDESGNDESEHGDSGHGESDNGGQETESVARPGEDDAIIMTLNGIRMSFPKGSVGEKTISVRAGESRDNAATKATGLDPDVVAPEGAEEPKTRGRRMSTGGSSNVERHPRARDRARSRQAAPASASPPRTQRLRQALDLRRPQVEIDRRTDLEDLTFQEDIERLELSERRARRLERLEAEEYQRAIEEEALRAQFEEKFRKEEEERIAKERKRKQAAIEEWKLAEIKRRENELNEFKEHLRDEFGYTEEETEKIVRKRAETSKKDKGRDEDEQQRRDTWIKVHRKYLLPDTLMAYHLPWDWDENDGNYIIIKQWIAEDMQEELFAHTRRIREGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM71</accession>
    <name>A0A8G1VM71_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_469285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515154.1">
        <property type="nucleotide sequence ID" value="XM_025662322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VM71"/>
    <dbReference type="GeneID" id="37165724"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="281" mass="32013" checksum="24DF89CD7FAF49C2" modified="2022-01-19" version="1">MSTPKPYDMGSSQSEESGAKAPTHIDYKLENIIAGALDDGGVPNVFCGHGLMSVYGLVQEQKSSTWVIPNFYIAEADSLLQEAGFHSCHRSYCEGYRPNKRPFAPAYHYHVQPRVNRPYNHVVLLYKMNDLFIDLAPVPTRLPPLDDPDYMLVDDPRLPDYNDEAGNGRWKSIRSIKIPKPARFIDAVVLLMVREWPQDPTSSIWYGYLSELLDHINENGDYELVPSWDVLGDSARGFVKFYFDGETKKSPCEVKNYISRLRDDMIEKTKLSLLLMADVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM86</accession>
    <name>A0A8G1VM86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_277381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516516.1">
        <property type="nucleotide sequence ID" value="XM_025655155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VM86"/>
    <dbReference type="GeneID" id="37158557"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027915">
        <property type="entry name" value="DUF4452"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39615">
        <property type="entry name" value="YALI0E17897P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39615:SF1">
        <property type="entry name" value="YALI0E17897P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14618">
        <property type="entry name" value="DUF4452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="201" mass="22062" checksum="221B15B351F5E2F2" modified="2022-01-19" version="1">MSTFFYGHQQQHQHQQHPHHGAAAHMANSNNHHGGRSRRGPKMTAQNAQRQFRGVKSMRELAEAPAVTAFRARFEAGRSFDLDDDLEFCPSLLTEDDLHSIHSASSDRSSLSSGSPDTSPLQHQIQPVQQVTPSISLSPASSNSYVHSGVSGNLNHVNFQQPSAVRTRKVIPIVNPNTGMTLTSPPTSISPASMQNAQRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMA4</accession>
    <name>A0A8G1VMA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Armadillo repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_72658</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513415.1">
        <property type="nucleotide sequence ID" value="XM_025665617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMA4"/>
    <dbReference type="GeneID" id="37169019"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000609">
        <property type="entry name" value="Armadillo repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH55493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="999" mass="109376" checksum="AD70BDEE86C19A12" modified="2022-01-19" version="1">MTRASAPPLLLQLQNAETLSAQAAALRSLKNETIGHDQRKESWVRWGILPVLANILAARQSPGKGTASAELNGGSKLRYPTSEEDEACLQAVIILGSLAQGGAAFLSPIFASGVLPALLSILSAPGCPSFFVQPILRTLNNVADRLPLQSQQISSKDTRLADLLFSNDHIGCLARILGQEYESHHDQAAIELTASLVGKLCTEEIHKAILAECGVLDALAVKVASFIVAQGFVLPGAEAHVQDTGALGSLPAPAPAGAKLAPILRAVTVIIEHSKWRAEHFLSSPGILTVFPRQLPEFAPTDIKKGPWGSTYFSGSAVPRHAGASPLEHLLPSVPLSQSKSPANTPNFPPLGHQGTTHRRHSQSYSTPMSAYDPPTSEDEENPIIPWLLYIVRAEGGMVRLMAARLVTVLFRLGLTKKRRVSMLCYLLIPILIRMLDKDYEMNGDDGVQYGGLIPSTERLREEAPFVLATLVIDDFELQRHAVDGNAIKRLSQLLKETYNPVQDVTRPMWHADAEENIDSSPDTLPAECRLGSLGFSPVHCHIMRYRENILKALAALVPFKDEYRKAVCENGVVPYIIDSLKPCSDDQSADPSGPKNTASHGNPTSTLLAACGAARMLTRSVSVLRTSMIDAGVATPLFVLIKHPNIEVQIAATQVICNLALDFSPMKEAIITADVLPTLCEHAHSPNTKLRIESLWALKHVAYNSTNDVKVRIIDGLSPAYIRQIITQDPTNALAKRGMDEEMDNDSNVGMGRANSAGEQVDLLNPVDNAAGQDEDMKMADTMPPSKMSLDMFLPDATRRRKLALHGNLDQTTQARQDDIAVQEQTFDLLRNIICGPGAAEMIDHLFKVIGQDLILDALADKLRPRSIQLPHRGESSAHRPLSVPTEILVSVTFVMIHLAAGLPWHRQLLVSHRDLLRYLMGYFNHTHREVRTNCVWVVINLTYKDDASEEEGCRERAFRLRAMGVMDRLSSLGDDPDLDVRERTRTAQDLVNHLTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMD4</accession>
    <name>A0A8G1VMD4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_448752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516651.1">
        <property type="nucleotide sequence ID" value="XM_025660009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMD4"/>
    <dbReference type="GeneID" id="37163411"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000191">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH58729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="144" mass="16159" checksum="0446732DC4964259" modified="2022-01-19" version="1">MSDPLLFEDTFTITAINQQKYDRVSRLSCNSTDTLSHFTLDVNSELYPCVVNESLNMALASTLSLDGKDDSGSKGWREVGMGEQTLANDYDYVCHGKVYRFEEGSSQGNMAVFISFGGLLLYLEGPYKKLAPLRIDYVYLLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMP0</accession>
    <name>A0A8G1VMP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7770 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_448023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516966.1">
        <property type="nucleotide sequence ID" value="XM_025659841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMP0"/>
    <dbReference type="GeneID" id="37163243"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056672">
        <property type="entry name" value="DUF7770"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24968">
        <property type="entry name" value="DUF7770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7770" evidence="1">
        <location>
            <begin position="11"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="122" mass="13603" checksum="D12B4BD7D4F5F95B" modified="2022-01-19" version="1">MTPSYSIPGATNPNGSKGFLIISYLEHTVPISTTAQKVVRMDARPGCRARDFLNLILSQKRHQYEFNFAGEGCRFWTTQQIDLFGRSGFLINPSQAEVARDAILTKWPSGVGYPLVVGTYYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMZ5</accession>
    <name>A0A8G1VMZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_265951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517148.1">
        <property type="nucleotide sequence ID" value="XM_025655052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMZ5"/>
    <dbReference type="GeneID" id="37158454"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="127" mass="14590" checksum="AD81D670994B163A" modified="2022-01-19" version="1">MSRIESLINLAAENLFFPMSLLLLLLSMSICALRRNSIYLSYFQFHHISTFTYYYTPTAPCLSFTTTHLHSWISRQLYLSTIITYTTNTNTPIICPSHLSHLSHLSHPSSQPASQPHNERESERASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNR6</accession>
    <name>A0A8G1VNR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Endosomal cargo receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_373443</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH56978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514900.1">
        <property type="nucleotide sequence ID" value="XM_025656082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNR6"/>
    <dbReference type="GeneID" id="37159484"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034503179" evidence="8">
        <location>
            <begin position="30"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="39"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH56978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="232" mass="25899" checksum="582093A08BA40E4B" modified="2022-01-19" version="1">MAPVRSSASWLSSLMAVCAILCLSVPANALYFYMDGRQTKCFFEELPKDTLVVGTYSTAVINQQSNTYNVDPNLKMLVTVDEIFDNDHRVVSKRDSHSGRFTFSAADAGLHKICVTPETNAATGGGWLSGAPSGAVQVTLDMAIGETSKIETEDKDKMQDIVQKVKDLNGRLQDIRREQVFQREREAEFRDQSEATNSRVVRWTLIQLAVLSVACAWQLSHLRSFFIKQKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNV1</accession>
    <name>A0A8G1VNV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_446845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518226.1">
        <property type="nucleotide sequence ID" value="XM_025659595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNV1"/>
    <dbReference type="GeneID" id="37162997"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="64" mass="6460" checksum="232204869D13DE0F" modified="2022-01-19" version="1" fragment="single">MEIGWLSGPLGEARREATSLQVATKPAGSARSTALAKSPGSMPRGAGFPDASADPVARPTTPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNX2</accession>
    <name>A0A8G1VNX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_368782</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517177.1">
        <property type="nucleotide sequence ID" value="XM_025655884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNX2"/>
    <dbReference type="GeneID" id="37159286"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF58">
        <property type="entry name" value="ZINC FINGER PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="433"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="256"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="457"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH59255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="486" mass="51712" checksum="E73A0070694E6040" modified="2022-01-19" version="1" fragment="single">AIRSPLLDPPDIAGGLSGSRYWTLASDSVAFPGHLSSTLAGPSPVVVGDLFPSSSFSRETSANLAALAIPPPGMGTALDALTTHQPLNSRRPAAPTLPSFELPAPNFQTSVKYAHHNPPPINPSVSNLLTPPATTQSGETLPATTSHTATTTAPTNPELAPYWQSQSAYQSGSGAAAARQSWNSSVVYPSRDTFSPSVNSLNRNPATSTPGTEHITQSYEMNHLPPFHQSASVSAAAPVQAGAPQQHHAMTHAMLSAHNPLPNPTPSPHPLPSNDPYMVKSSSAPAYGTIQQLSSPPGGYSPYGQQGIVPNRVASNPHPSHHLNYQRQPWPSYSLPAMNGPIWTNVHNPNGQMSLTGNLQSGVLPGLPGYNSGHVANMQQMQQLYGGHPPHPGHGAPGPTNDRPFKCDQCPQSFNRNHDLKRHKRIHLSVKPFPCTHCDKSFSRKDALKRHILVKGCGKDGSDGMKPGDHGMVKEEDRSDESNGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP73</accession>
    <name>A0A8G1VP73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_447243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518601.1">
        <property type="nucleotide sequence ID" value="XM_025659679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP73"/>
    <dbReference type="GeneID" id="37163081"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="53" mass="6088" checksum="76F66FEDD0A6451B" modified="2022-01-19" version="1" fragment="single">MIPEIRNTQSSMNLTYLLMYLITHLYAACSMHCTYLPQLIQLSIPTSSEPKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPK2</accession>
    <name>A0A8G1VPK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_180529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025654347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPK2"/>
    <dbReference type="GeneID" id="37157749"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14438">
        <property type="entry name" value="SM-ATX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="183"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="915"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="975" mass="105564" checksum="347170F73C8D6333" modified="2022-01-19" version="1">MSHKQSASPRPTPKESNTPDNHANDRLVFLFASFIGLNATITTRNGDKYTGIFSSSTLEPSDCSFVLKMVQRPTKADQNKANGVSDVSSPYMGSAPDHSMSFDVKDVVDISVPNVTPADVTAKSANGTPVGFKTDTDISGNLAIRERTLKRWEPAADTDVDLSLESAHNLTGWDQFEANARLFGATSSYDENIYTTRIDRSDPTYKQKEADAARIAREIEGATTDNAHVREERGQVSADDHDEEAKYSGVRRDERNFPPLVSGQPNKYTPPARRQNAAQSAMAAGAPASSLKQVPSAPKDAVAAGPPKENGQAQAQPAPSSITASSAADTEQKPALSKTTSGAPAPANATSNVEAEVLDSFRQFAHSEKAKLQERRRNQASYDRTIKLNELMKFSKNFKLATPVPKDLVPILAKDPHKQEEIIQRAQQHAEEKVVTKSPASAESKPAARPSGNARQESGTMPPPAQADRQNYPRGRQMFPPTGPHAGPGGRLPQQPVHQGRQATGMLGHRLADNIQQRKGAAMGTVPAPLPINEVRIPPTGPAGEQPAVTSPNKVQTPTSSVSTKFNVRALEFKPNPAASTFTPGASSTSSPFTRGRSVSRTTSPSLFFGAKKPRPISERPSLNDQFNPIKRMKKENAESNEKGFAFNGGIPPAYRTPPTWDAAPGNEEKTYLEMFKPPASVPAISPQSRSASNPQMPPPQMPFQFPQNTPGMPPTTGPPHGPHLHPQQHHNSGPPHFDDPHRMQMSASTSQVFPSPRLQHGYPSPMAPHAQLAFGQAMPQFYVSQAGTQPGHMRHYPGGPQFVNPQPTMGAPMMVQQPSSGPYMGVPQGVAPYTPQMQMYSPNPSHAYPQHVPPPQPHSGYPSPSRGAPMMMHQNSQPGQPPQPVMFMSPGQHGQPVYPTQQPTHMPPVRGNYPQQQPHFQSSPHQVHHYPPHQHRTPSSGYNQMPQMPPQMPAQPPSTVASGPQPQEAADEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPT4</accession>
    <name>A0A8G1VPT4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">tRNA wybutosine-synthesizing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_466766</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518092.1">
        <property type="nucleotide sequence ID" value="XM_025662145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPT4"/>
    <dbReference type="GeneID" id="37165547"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000196">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="17">
        <location>
            <begin position="122"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="432"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="42"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="305"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH60170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="772" mass="86786" checksum="31FD68E445DA5A38" modified="2022-01-19" version="1">MEASANEGFLAFWHSYRLPLLLALATLVVLVRAYHKLQPKSKIATASSIPSSPRSHSPEKREKTISQSTEKDVKADSKRSVVEKDASQKQAGPKRVTGKKPLKVAGRRRGSDHEPPVSFIQPIIFFASLTANTERYAQVLLEDLRAAARDRADPENRERGLLPPQIHDLSYVDFDDYFISAPKPPSTSPGTRYVYCMLIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYSVFGFGDREGWPTEEEGFCSQAKELDRWMAKLTGRKRAYPLGFGDVKSDADSALKEWSRGLQDILGDIVENGGLGEGVPGSGDPLESDEEDLDDEGSDSDKANGRKKNKNQSVVDLEDIKFSSDAASGSPIPVDFTTGGKTPAPATEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELIFNGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEHISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHYQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQNVPFYEEIQQFVTSLNAELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFFQLLEKEKADGTSFTPEDYMRETEDWALWGNGGFDPNDERVYRKGKKKAIQAAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQI4</accession>
    <name>A0A8G1VQI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ilp is an apoptosis inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_434511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519788.1">
        <property type="nucleotide sequence ID" value="XM_025658475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQI4"/>
    <dbReference type="GeneID" id="37161877"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053267">
        <property type="entry name" value="Verrucosidin_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087:SF1">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32329" checksum="87EACFFEF38AB51B" modified="2022-01-19" version="1">MHDFQQFNSAAMVGLAQASAGDNFDIFQWHPRYQSCQRYFLDHAQHSDAVQALSAFLNIRLPFQWQSNPVVNSHTDPSRSAASQSSTSSPASNPPPSVSLIPYIRRLVATGMDFPGVLHGFFGDEWGAGIGPLHEQERRNYLFAAKSGGWAAVKKDYDMPPLETIPFLRPLQGPLDSEIEAAERSWSEWLAMEDWMVGPRAPDVLQDSSSQISRHHSSRGHAGGSTELPMNALSNKENALQVDTQFTLVKSTRLITYIRTIPILTYELYPRLPMNPTESPAPPVPHYLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQW4</accession>
    <name>A0A8G1VQW4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA(Phe) 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4)]-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_448157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36635"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TYW3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.282" evidence="2"/>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517120.1">
        <property type="nucleotide sequence ID" value="XM_025659874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQW4"/>
    <dbReference type="GeneID" id="37163276"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1960.10">
        <property type="entry name" value="tRNA wybutosine-synthesizing-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003827">
        <property type="entry name" value="tRNA_yW-synthesising"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036602">
        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02676">
        <property type="entry name" value="TYW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111278">
        <property type="entry name" value="SSo0622-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA wybutosine-synthesizing protein" evidence="10">
        <location>
            <begin position="9"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="277"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH59198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="330" mass="36885" checksum="580A72F82C33C6EF" modified="2022-01-19" version="1">MIPEVFESRKRKILADLSIPDAEYTDLSPKGSVDEGIRILINDINTLPGLVTTSSCAGRISVFLEGRKKQQQQQQQQAVSDEQQQQQRQFVPSGGKGAGKWLYVSHEPLQEYGKVREKEQERQPLHELFGMMPGDGRPPGLNKDGQAPRLVRFSFEPMILHIMTATLHHAHPVLSAASTSGFRESGLQSLRCLEANDIEGPSPIVAVRSAGLSLESVIGYCEETDDDNDDNGEPIIRSLVTEEFLEMLVAISNERFAVNSERKERFRANLLDLCSTDHTKAKGKSKPPGWEDPEKRRERMRAEGLKRKQLAQNQRKDDDADLDLSGASLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQY3</accession>
    <name>A0A8G1VQY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_194536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519262.1">
        <property type="nucleotide sequence ID" value="XM_025654460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQY3"/>
    <dbReference type="GeneID" id="37157862"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="105" mass="12037" checksum="E3C12055ECA880ED" modified="2022-01-19" version="1">MNSSINSRPSRDTMRAESPLSLPPAPDALQQSVRSVHPSKPDTEKEELLVQVNTLKYELENFKQERDLMVLRHEKELRDLQLKADSDFRKAQRVTATGPPTRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRC5</accession>
    <name>A0A8G1VRC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_455888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519682.1">
        <property type="nucleotide sequence ID" value="XM_025661414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRC5"/>
    <dbReference type="GeneID" id="37164816"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034304247" description="DUF1996 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="41"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="195"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH61760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="395" mass="44314" checksum="F897D6FAC08049F7" modified="2022-01-19" version="1">MWNRYIAALLLLSSGSNVLAKQRTTDEFTFSCDPLTTQLSDPIVAPGKPSTHTHVVTGGTAFQRTMNESTAQNAKGTTCEVDIDRSNYWVPQLYHRMRNGSFELVEYQSSVGISLDFIESPGSLVEGREELANELDRVFITLIERVIIRPVLRIVMRSWFRWRRRKVCACLLGIRVFGLFACSLSRCLTVLISDGNRTYNDSNWSQRAISHMCIGKDGSSNETKGLPQQPCEMLRSQVFMPSCWDGENLDSSDHKSHMAYPDTGDYNKGVCPKSHPVAIYSIFLEFFFNTAPHPDYKNWIYATGDKTGYGLHGDFMYGWTDQVALQQAIDTCTGPQGLTDPDCSITRNQTRDLAPISQPLDVPAPKDNIGQHGPVNRLPGHRNWATKHNNSTLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRT5</accession>
    <name>A0A8G1VRT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="5">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BO85DRAFT_444562</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of Ku70 and Ku80.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521183.1">
        <property type="nucleotide sequence ID" value="XM_025659041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRT5"/>
    <dbReference type="GeneID" id="37162443"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01458">
        <property type="entry name" value="vWA_ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000004">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000071">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.970.10:FF:000003">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000001">
        <property type="entry name" value="X-ray repair cross complementing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00578">
        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="SAP" evidence="22">
        <location>
            <begin position="617"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="560"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RAH63261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="653" mass="73395" checksum="21C5F8B9E76A7FD9" modified="2022-01-19" version="1">MADGNPHREDEAAEEEEEIDETSYRSVKDAVLFAIDVSDSMLTPRPSADPKKHTQESPTTAALKCAYHFMQQRIISNPQDMMGVLLFGTQASKFFEEDEDSRGDLSYPNCYLFTDLDVPSAQEVKELRALVDDDGDSRDILAPAKEQVSMANVLFCANQIFTSRAPNFLSRRLFIITDNDNPHGDDKTLRSAATVRAKDLYDLGVTIELFPISRPEHEFKNSKFYDDIIYKSSPNDPEAPAYLQTDAKAATATGDGISLLNTLLSSINSRTVPRRTHFSNMPLELGPDFKISVSGYILLRRQAPARNSFIWLNGEKPVVAKGVTTHSADDTGRNVEKWEIRKAYKFGGDQVTFSPDEQKALRDFGEPVIRVIGFKPITALPFWANVKHPYFIYPSEEDYVGSSRVFSALHQTLLRNKKMALVWFIARKGAGPVLAAMIAGEEKLDENGVQKYPPGMWILPLPFADDIRQNPETTLNVAPEPLIDQMRVVVQQLQLPKGVYEPLRYPNPSLQWHYRILQALALDEDLPEKPEDKTIPKYRQIDKRAGDYVLSWAEELEKQHAKTSTAAPHPTSTLVKRGSKDRASETEDSKPSKKVKVEEGSGNLEEEVRKHHEKGTLSKLTVAILKDFLASNGRSNAGKKADLIERVEEFLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSF3</accession>
    <name>A0A8G1VSF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major royal jelly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_410254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520807.1">
        <property type="nucleotide sequence ID" value="XM_025657470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSF3"/>
    <dbReference type="GeneID" id="37160872"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF18">
        <property type="entry name" value="PROTEIN YELLOW-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034965918" evidence="4">
        <location>
            <begin position="20"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH62885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="393" mass="42589" checksum="6B78F87C3D5D65BA" modified="2022-01-19" version="1">MLISIIPLLPFLVASHVNGLAHDSGVYGPSLELVHQYYDQFPTGIAVSSTGRMFSCYPLGLDANNTRYQVAELTDSTTEVPYPSAEFNYPPGGATTVNYADHLISVQSVVVDAKDRLWILDTGRATTANNTLLLSSYGGPKLVGVDLATNKVFKTILFPRDAVYPDSYPNDVRFDLRPTLPNTSGEGIAYLTDSSPEGRNGLIVVDLGTGKAWRQLDGLSITKAEPDFRAFIWGDVVDVSTGTDGIALSADGETLYFGVVSGRDIYSVPTAVLRDDSSEGRAKAVKCVTKIIQKGVSDGYETDSDGQIYVGSFESNAINVVYPGNGSVETFVRDPRMGWTDTMSVVSLGVNGNGTEERGYLYFTENQLWRQERERPFGLFRVELPGGAGKVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VT39</accession>
    <name>A0A8G1VT39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_495558</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521499.1">
        <property type="nucleotide sequence ID" value="XM_025663939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VT39"/>
    <dbReference type="GeneID" id="37167341"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="44"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH63577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="519" mass="55981" checksum="F9826253DCB56A34" modified="2022-01-19" version="1">MKLFKKTEEHELPNSEHTEVAAKDPATEVDDIEKTDAGAFVWLVASTASIGGMLFGYDTGIISAVLVYLHDDLGHFLSPSEKEMVTSLCSAGSFVGAIIAGLTADKYGRKGAMYIACVLFTVGAILQASAYSIPQMAVGRFIVGFGVGSAAMVVPAYIAEIAPTKYRGRMTGLNNVSITGGQVISYALGAAFAPVSSGWRYMVGLGAVPSLLFGALLPFCPESPRQLVCHGKHEQAAGVLQRIFHNASPEQVSAKIRLIDETVQESRLLDQSHRRRAIVKQLHTNAAYFRALVCACGLMVIGQMSGFNVLMYYSGTLFSLVGFSNPVAVSLVVSVTNFVMTCVNMAVVDPFGRRRLLVSTVWGMGVGLLAVAVAFLYLPVDLETLEMQEKEVTTPAIVVLVFIIWFVIFYGVSIGNTAWMSTDFFPLEARAIGSMYMTCCCWGSNLIVSSTFLSMMKGITPSGAFGFYAAICLTGWVLIILFYPEMSGLTLEEAQEVFRHGFGVKYASALRKARRNGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VUV6</accession>
    <name>A0A8G1VUV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UMTA methyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_495032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521155.1">
        <property type="nucleotide sequence ID" value="XM_025663898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VUV6"/>
    <dbReference type="GeneID" id="37167300"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32656" checksum="784FCA3F1836CB11" modified="2022-01-19" version="1">MRIPKNNNAPQLPTVESWNGTTVKAKDPYALMRDCNANTRLTAQHYLWKELLGFLVHPDIDTRAADLKVADIATGNGIWLQDFARGKPPSVDLHGFDISLDQVGPKPWLPANIHMHVWNIFEEVPDEFIGYFDVVHVRLITVVVKNNDPRPILANLKKLLKPGGYLQWDEVDTIGCSIKTVPGTSASNLDALFSQLKGHDTWKYDLTRIMDENGYTGSMLYTYEYGLGNARFWNDVYVSTWKEFAENALKTPEASKSLEHNAMMETLNGASIMVPKLVWVTKKVDTVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VV72</accession>
    <name>A0A8G1VV72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_361201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521485.1">
        <property type="nucleotide sequence ID" value="XM_025655583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VV72"/>
    <dbReference type="GeneID" id="37158985"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="57"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="513" mass="58703" checksum="8D693633D22DA966" modified="2022-01-19" version="1">MNKDGIFRYQRYKWLSGDSKHLAARYRDFNLDNLLEAAVQATGRDGTKCVKVLKCLEGQYNKAFVLTMNNGEELVARLPNPNAGPSFYTTASEVATRHFVREVLGIPVPRIYAWSADSSSSIEAEYIIEAKAEGHSLGSLWGRMSRSSQFGIIDQIVEIERKLASVSFHMQGCLYYTSDLKSKVPDVKGLDTMLSISPGLKIEDCRQLSCFGVGPSNDRNLWNGERHSMNQDRGPWTNPIHYVTALGSNELDWARCHAKPRMNYYRSTETPENPNEYLALLQRYFDIAPHLVPKQPCSEYDNINTLSHPDLHLDNIFIDPETNQITSIIDWQLAAITPSFLQHPHPQMLELSLSPGSEEQRSREKELLEYYYKVTEKLNPSRAEAFNDPYLSTRVAPINLISGCWEREDTFSLRESLIKVAAYWDQLRQDDAPCPVDFNVDELAEHERERELIGGLSNIVQQLEEEGLIPIGGMVRPEEYEHAKMVSEYFKSEFINLAEGNQQRELHEKVWPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QR68</accession>
    <name>A0A8G1QR68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_208116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510240.1">
        <property type="nucleotide sequence ID" value="XM_025654590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QR68"/>
    <dbReference type="GeneID" id="37157992"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="148" mass="17022" checksum="C13E3F51EA8406E5" modified="2022-01-19" version="1">MVNKSCVRMMRSYCSRVQASKWTLIHRTWRLNLHTDYEHVLHQCILDGNVRSLQVRLNLPTVRLCVLSIDGGGPRGVIPLKIWSCSKRLWDRAPESEIACPLHRYVVFVVFDWSGTRSNQVLCLAIRSKILLHLVHVCRADSSVLDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRB1</accession>
    <name>A0A8G1QRB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FGGY-family carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_472269</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510808.1">
        <property type="nucleotide sequence ID" value="XM_025662543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRB1"/>
    <dbReference type="GeneID" id="37165945"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019321">
        <property type="term" value="P:pentose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07782">
        <property type="entry name" value="ASKHA_NBD_FGGY_D-RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006003">
        <property type="entry name" value="FGGY_RbtK-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01315">
        <property type="entry name" value="5C_CHO_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435:SF4">
        <property type="entry name" value="FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435">
        <property type="entry name" value="RIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="6">
        <location>
            <begin position="35"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="7">
        <location>
            <begin position="333"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH52886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="612" mass="67074" checksum="4246C065895FF6B0" modified="2022-01-19" version="1">MASIPQMPYRRPSRQGSRQASIDTRDEIQVRVDHYIGIDVGTGSARACIIDSKGDIVGLASENIGLWQPQQGYYEQSTNDIWRCICVAVQRAISQHNIDPETVRGIGFDATCSLSVFSNVTNEPISVTGPNFNSDRNVILWLDHRPVEETERINATNHNLLRYVGGKMSIEMEIPKVLWLKNHMPKELFDQCKFFDLADALTYIATGAEQRSFCSVVCKQGYVPVGVDGSVKGWQEDFLKQIGLEDLSKDDFKRMGGVDGVNGNYLSAGELVGTLCDRAASELGLPPGIAIGSGVIDACAGWIGTVGAKVDLESEQLSSDIAKNDKAQAFSRLAAVAGTSTCHLAMSPDPVFVPGVWGPYRDTIQPGYWMAEGGQSATGELLKHVIETHPAFNQALSIAESYNANIYEYLNEHLREMVHDQKAPSISYLGRHIFFYGDLWGNRSPIADSAMTGSLIGMTSDKSVDGLTIHYYATLEFIALQTRQIVETMNKAGHSLTSIFMSGSQCQNDILVKLIASACDMPVLIPRYIHAAVCHGAAMLGAKAASADAEGKTEDLWSIMDRMSKPGKKVVPTTDKTEKALLDAKYKVFLEQCYKQQEYRALVDQAVASWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRS6</accession>
    <name>A0A8G1QRS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Six-hairpin glycosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_505270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511048.1">
        <property type="nucleotide sequence ID" value="XM_025664327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRS6"/>
    <dbReference type="GeneID" id="37167729"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034643097" description="Six-hairpin glycosidase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="76547" checksum="B1CE20048AC8C96D" modified="2022-01-19" version="1">MWLLLHLLAVIPICAITEASNYTYTFSSGHALLYSNSSAIVQFVDGTNPQRQFLLNETTATFHTRSHAWGAGTISTDSGEGSWNLDHIPYNNFTGPYNIPLDDGLRLRIIRSPGRVLTETYIFENTSPERTTVTGLHIQTPFNDLYDTALWSLTSAVNAHIFTGGAWAWALAEPMSGEGRSLGLIVRKGHLWSYSLESSTSSDVRGHIVLQVTDAKGDPNGFGGQPVAYIDSGDSYVLEWEIGFYNNTSDFIEATKPPATFSAYSAPLDQEITVSSEIKPTSSTSNLKIRRRGTSYTLSASSPGTYNVDIGDSRTEISFHLPLETVVRERAHYILEHQRPVQRPAPLNAAFVAIDTENLTTIVSSTWDDWGDGSERIAMPTLLQLAAMQGYISSELVDIPLRNWVEFASTSLFDSEGNTRRCTGCSQTQRPYDAIWLVMFFNDRYKWLGNSTNIDTAVTLLNRAFEVGRVQEAPIIFFSQAILELCDSLDKLGRYNESATYKRKLVDTTMSFVNDGRDLPASEVSYEQSIVEPLVEMVADTFNLTRNATLLSQTQERLNWLMAFSGSQPHARLYQIANRHWDDYWFGLRRQWGDVFPHYWSALTSQALIRLPRELRTKQTDDIALKILRSNMVNFFPGGSATCAFVYPSAVNGNSANVADPMANDQDWHLVIWLRLLEYGVPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS95</accession>
    <name>A0A8G1QS95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA-splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_453568</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510840.1">
        <property type="nucleotide sequence ID" value="XM_025661081.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37164483"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17935">
        <property type="entry name" value="EEXXQc_AQR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000507">
        <property type="entry name" value="Pre-mRNA-splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048966">
        <property type="entry name" value="Aquarius_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048967">
        <property type="entry name" value="Aquarius_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032174">
        <property type="entry name" value="Aquarius_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026300">
        <property type="entry name" value="CWF11_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF5">
        <property type="entry name" value="RNA HELICASE AQUARIUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16399">
        <property type="entry name" value="Aquarius_N_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21143">
        <property type="entry name" value="Aquarius_N_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21144">
        <property type="entry name" value="Aquarius_N_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038901">
        <property type="entry name" value="AQR_cwf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="1 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA helicase aquarius N-terminal" evidence="6">
        <location>
            <begin position="28"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius beta-barrel" evidence="7">
        <location>
            <begin position="491"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius insertion" evidence="8">
        <location>
            <begin position="705"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="4">
        <location>
            <begin position="808"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="1116"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="750"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR038901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH52918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1420" mass="161032" checksum="5D1BEC9E704C68DB" modified="2022-01-19" version="1">MGLQTRQAMAQGLDSRPTVEDFREDSAWVRLAKSHWLDGSKARKVKQDVLKKDLWDPLEAENFSFRSLLTLENLNILEKFLWPTYTEDASNYHVLLLALIVSVKQREHLPIWDTFSDRPADFSNLFHRILSMSVDPSLGTSSRLSIVSFIISAFQSVENPLIRKECAPLVSISIWHNLSSEEARDRLLARSSGLKKAWRAAGKRYDAGDDAGKAKMRFERSWLYTMLLDFFRRLNGPEREQADNLRYCERLLEFLVDLESQPPTRRYVNTLLKDLNFLSVIRLSQLYRSADSALFRDLCGLLGHFSAFAIDDFTGEALSPQAIYDAHCQELARLQRTSMKYFKDKLMILALSNYGSIEQRSELEGQLATLEESELRDLCSHLGFRTDYPKQSQITPDRHLYMEVLLSFYEKKTTFQEAASQLSIVPTDENLYDPTLLRNETYDGSKPLAIPKLNLQYLSTGDFLWRSFLLYRSEAFFQIRKDMESIVKRMQPRASRDGKTLNFDGFSRMAIPITKPAIIEVAPPKVGSAKPAFVRAEIAIEVGRLADHIRMEWESLRPDDVVFLLAVQSDDAGKPGFREPETPGLKYLRTAEVVQVLDENGRPLREPASGQANGHRYRPRVRKLLVNLDSAAFKADKDGLTRGKPDVYPLINVVARRKGRENNFKSILETMQKLIVSDITLPSWIQDIFLGYGDPAGAQYTQLPNRLRSVDFRDTFLDWQHLVESLPGSTIEPSKEEASSFGPPYVVEYVEEPSKTPSAETSKKRRREQAEREAGPKSLRVSTYKPPNPGPYPIDAPKLNTVRFTPAQVEAIASGTQPGLTVIVGPPGTGKTDVATQIINNIYHDFPNERTLLIAHSNQALNQLFQKIVALDIDERHLLRLGHGEEELETETSYSKYGRVESFLENRNHFLGEVIRLAASIGAQGAHGNSCETAGYFNTVYIQPAWAKFWDQARSESASTEEIISAFPFHTYFANAPQPVFDATATKETLLDVAEGCQRHIDKIFSELEDIRPFEILRQPKDKANYLLVKEARIIAMTSTHAAMRRQEIADLGFHYDNVIMEEAAQITEIESFIPAALQNMKNGELPLKRIVLCGDHLQNSPIIQNMAFRQYAHFEQSLFLRLVRLGVPVITLDQQGRARPSIAELFRWRYQQLGNLPAVETAPAFKQANSGFQYEYQFINVPDYQGTGEREPTPHFIQNLGEAEYAVAIYQYMRLLGYPASKISILATYAGQTALIKDVLNHRCAKNGLFGMPKIVTTVDKYQGEQNDYVILSLTRTRTVGYLRDVRRLTVALSRARLGLYILGRREVFESCYELKPAFDLLFQRPDKLMLAPGEMFPSARSLDDEVQGTPMESVEHLGQYVFEMTQAKLKAMGGETAVNNEMDIGGDEEVVMDEDEVMLGAGEEGDDDPLHEHTFTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSA7</accession>
    <name>A0A8G1QSA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_505973</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510626.1">
        <property type="nucleotide sequence ID" value="XM_025664360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSA7"/>
    <dbReference type="GeneID" id="37167762"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF232">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 13 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="20"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH52704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="601" mass="69292" checksum="297938F19ACC251A" modified="2022-01-19" version="1">MCPKSHYSTPKWWKEAVVYQVYPASFNCGTHTSKTNGWGDVTGIIEKVPYLKSLGVDIVWLSPIYTSPQIDMGYDIADYKSIDPRYGSLSDIDLLIRSLGDHDMKLMMDLVVNHTSDQHSWFVESASSKDSPKRDWYIWRPAKGFDDDGNPVPPNNWAQILGDALSAWTWHEETQEFYLTLHTSAQVELNWENPEVIAAVYDVLEFWLRRGVCGFRMDVINLISKDQSFPDAPIIDPSSKYQPGEQFYTNGPRFHEFMHGMYDNVLSKYDTITVGETPYVTDIEEIIKTVGSTAKELNMAFNFDHMEIEDIKTKGDSKWSLRDWKLTELRAILSGWQKRMKQWDGWNAIFLECHDQARSVSRYTNDSDEFRERGAKLLALLETTLGGTIFLYQGQEIGMRNFPLEWDPDTEYKDVESINFWNKSKELHPVGTEGLAKARTLLQKKARDHARTPMQWSAAPHAGFTVPDATPWMRVNDDYKTVNVETQMSFPWQSKGELSVWQYWQQAVQHRKLYKDAFVYGGFEDLDYHNEKVFAYLRTSADGKDSWLVVMNWTTSAIEWTVPSDIHVTRWVSSTLQTAPPVAIKRSITLRAFEGILGCCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSB4</accession>
    <name>A0A8G1QSB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Terpenoid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_481181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511318.1">
        <property type="nucleotide sequence ID" value="XM_025663046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSB4"/>
    <dbReference type="GeneID" id="37166448"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF72">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G01210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH53396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="75383" checksum="28AACAA87CABE4B1" modified="2022-01-19" version="1">MECSTTWINSTTVNEIDVRNSGAFTTLPVRVSKYNEIAITAAQKLACIWDTIRYGGVSSRPVNVGRNLLPWVVPEALPDRMATAVKLIELGHLCDAFSEQLDSQSRAEVYNMLTRCMDRCSVASASSCSCPSACNKEFDDRQAQLRTLIYEVATEAIQFDREQGILILELLGKAVAPEPMSFGCRKSSAFRHRTFWPILEFAIGMKLTEMDRIVLRDIKTVVDEYHMLNDEYWGANITTTASYQTDFCRMPNLPFQGKEGLKSRIMDLEFRYRSLQADIYAKYPVESMRLRRWIEAAGMAMAGYNYWRALSSSGPCNSSSSACSCSPSEWTRVTTPASTMSFSSSPHTSYSGTYERSESTTLTAVTNYISSMPPSPSVQILNMAPSALNTWTRAPPPAVKCISSLITSLQNATTTLTDITADNTHRYNQPTAHAVFGTMQATNSAYYTFIQSVSEARALANPALATDILLNGFNRLYAGHSRELNWKYNACIPSEAEYLSVVDDTTGSLYTLLVNLLQAESCIPFHCKPDLTPLATLLARFVHVKEDYLSFHNRDTQLSKSTDARVLSYPVIRLANIKPDSRAQISRYLFEGSKEATKSGGGCSCAAEEKRDPCGNSVNYSCLVLLLREYGALAATRDLLRDIEDKIEKEVVQVEKMTGEVSPMMRRLIAGLREGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSR1</accession>
    <name>A0A8G1QSR1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_504850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511095.1">
        <property type="nucleotide sequence ID" value="XM_025664313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSR1"/>
    <dbReference type="GeneID" id="37167715"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000044">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="25"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH53173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="714" mass="79545" checksum="B947058D75550E25" modified="2022-01-19" version="1">MFLSVVPYTAQYGSPFSRSKQGKVAELRQELNSGGKKDKNHSAKKIALKKIVANMTMSNNDMVALFPDVIGCMNLPSLEIKKMCFLFLVNYSRAKPEVALKALPFLIDDMEDSNPLVRALALRTISYIHVREFVEATVQPVKRLMSDMDPYVRKTAAFCVAKLYEHDKKMVEASDLIDRLNSMLKDENPTVVSSVLASLVDIWGRSESISLTIDYTSASKLVSILPDCSEWGQSYILEALMSYVPQDSAESLLLAERIAPRLSHSNSAVVLTSIRVILYLMNYIADERHVTSLAKKLSPPLVTLLSKPPEVQYLALRNAILILQKRPEVLRNDIRCFFCNYNDPIYVKVTKLELIFMLTTKENISVVLAELREYATEIDVHFVRKAVRAIGKLAIKIESAAKQCIDTLLELVNAKIPYIVQEATVVIRNIFRKYPNQYENIIGNVIQNIDELDEPEAKAAIIWIIGQYADRIENSDGLLQDYLATFHDETVEVQLALLTATVKFFIQRPTKGQQLVPQVLKWCTEETDDPDLRDRGYMYWRLLSTDPKTAKQIVMGEKPPISAESEKLDSRTLEELCLNVGTLATVYLKPVQQVFRSARTRRLQYSPALQKPKEEPGTAVWQFPAPSQSNSPTAAMAASASAPSDMNAAVSAADSYFNSVGTQQMAALDLGGREDGGVGGGGAPQTQYVVTQNQQQVYQPQLAGGAATGELLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT53</accession>
    <name>A0A8G1QT53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_481903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825085">
        <property type="protein sequence ID" value="RAH52347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510269.1">
        <property type="nucleotide sequence ID" value="XM_025663080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT53"/>
    <dbReference type="GeneID" id="37166482"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="211" mass="23441" checksum="0A9013CE4C1EAFDD" modified="2022-01-19" version="1">MANHTNRRRGNRRQQEEPCQPSLYCDPSTMRQSTFGPELPAVASAPVHDTFCPNLPQANHLAMRLDHQQKEVENWNKMQMEQFRFPGPQPMYEAPGLAPNGPPLSPDSRAMSPMYTMPPMHYAPYALPATGPLIVGSVQPRISGERETFQGLKAGASGNTRNCYPSSTLRGDAPEFVPKAKRQVNEAQRLVPNANTVFIVSSTGQHMMRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTJ5</accession>
    <name>A0A8G1QTJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylamine N-acetyltransferase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_523620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511249.1">
        <property type="nucleotide sequence ID" value="XM_025665368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTJ5"/>
    <dbReference type="GeneID" id="37168770"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="324" mass="37083" checksum="1CF9BC75D571169A" modified="2022-01-19" version="1">MSYTPAQLDQYFERIKLPHDTRARLSARNKDLEVLTSLVRHHVAGVPFENTVLHYTPQQYFELKPQGLYEKIVLRRQGGTCFQVVRILSEVLLSIGYTLYNSAARLNAAASISLATTGDPNRPVGAQFGDWQHMVLIVRVDGQDYLVDGGFGPNCPVQPIALRDGYEFVDGRLGRRGRLIYDNINKGRAHHLKYWRLQFQSMKSTAAPWMDVYAFKECEWLDTDYEAGARAVGTNKRVWFRFRVTAFQYVLEEGVPAGWVMLWHNMLIRFHGGKVLEKSFLESEEERIEVLADVFGIVLTDDHRKEIAGMFSALPPKKARPSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QU47</accession>
    <name>A0A8G1QU47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenases/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_503596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511549.1">
        <property type="nucleotide sequence ID" value="XM_025664239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QU47"/>
    <dbReference type="GeneID" id="37167641"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="262" mass="28964" checksum="72CC88F2B1137019" modified="2022-01-19" version="1">MSSLNFSCALVTGGGGGLGKAIASYLLEQGKKVIIAGRTESTLRETAKEIRATDYFVLDTGVTSQIPTFIESLIKKHPDLDCLINNAGVQRPLQVLKDNPTEFLTKADQEIDINIRGPMHLTLGLLEDFKNKESAMIMNVSSILAFVPFSVINPVYNGTKAWLHFWSMNLRSQLASGGFDKIKVVEVAPPSVGTDLHRDREDPDDNKKHKNPNALTVEEFMDFFKEGLERGDAVIAPGMSREFVDKWEREFGSAYVKLTGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QU82</accession>
    <name>A0A8G1QU82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_505905</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510601.1">
        <property type="nucleotide sequence ID" value="XM_025664356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QU82"/>
    <dbReference type="GeneID" id="37167758"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="44"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH52679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="513" mass="55663" checksum="3DC15AA261991AFD" modified="2022-01-19" version="1">MNDNPSSSSATETNAPDIEKEPDQNAPPRLDVFSVFTVNQKRAMVATGSMASFFSPLSSSIYFPAMDTIAAALNVSTSKIDLTVTTYLIMQGVAPMLIAGFSDTAGRRPAYIICFTVYIAANLGLGLQNDYSSLLGLRCLQSAGSSGTVALANGLVGDLVTSAERGTYIAFASLGSMLGPSLSPIIGGLLSQYLNWHWIFWFLLIYSAAFFLPLLLFLPETCRKVVADGSVPPPTLNKNLSDTIRHRNRKAKGLVVEESKLAEVRKNYSFRCPSPMSTLKVTADLETAVILLATGLTFACFYAVMTGATTSFHDTYHLNDIETGLMYLPIGAGGIVSAFTTGRLMDWNYRRHAAKAGLPIIRNVRQDLTNFNIEKARLEVGLPMYYTCIVSMIAYGWVLGHKVNLAAPIILLFISGWSLNGTSQVLNAILVDLWPSRSAAATAACNLFRCELGAAASAAITPMSEAMGQGWAYTTLGLITVIVSPSLWVVMQKGIKWRQRRLRKERERAGISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUA7</accession>
    <name>A0A8G1QUA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Subgroup IIIi aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_452959</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511721.1">
        <property type="nucleotide sequence ID" value="XM_025660955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUA7"/>
    <dbReference type="GeneID" id="37164357"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH53799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="364" mass="39569" checksum="196C24F84BDA552A" modified="2022-01-19" version="1">MGSLSPFPPAPKAGLDWANLDMTKHLPVNGHVELRFHQSTQSWTSPSLVTGNQISISGLCPGLNYGQQCYEGLKAMRRRRHRHGSQEAEETIAVFRPTFHAARMARSADAVCLPPVPEHLFLECIRLAVAANAEYVPPLDAEGFLYIRPVLFGASDGLPLGPCEESIFAVYCHPARAYHGMQGIKGLVCEEFDRAAPRGMGRFKVGGNYAPVWRHAGKAQKMGYHITLHLDSETHSLVEEFATSGFLGHKVVDGQDVLVVPESENAIESVTGSSLQVLAKSKGWRVDKSPLPFSSLGELDEVIAVGTAAAAVPIASIDRLSTGEKYVFQATGDGKLCDLARSMRAIQKGQAPDREDWCFEVTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUM7</accession>
    <name>A0A8G1QUM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_147955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511880.1">
        <property type="nucleotide sequence ID" value="XM_025654121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUM7"/>
    <dbReference type="GeneID" id="37157523"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="51"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="273"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH53958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="529" mass="56811" checksum="7665098CEFEC6870" modified="2022-01-19" version="1">MTGASKPDEAEPVLSTLEGASNPPTPNAAAAAYRYKADLLNCAIQDIGMGRYQWQLFGVIGFGWASDNLWPIVTSLILVPVSYEFNVARPPLLSLAQNIGLLAGSLFWGFTCDLFGRRWAFNLTIAITAIFGLVAAGSPSFAAVGVFAALWSFGVGGNLPVDSAIFLEFLPGSHQYLLTVLSINWALAQLLANLVAWPLIGEMTCASADHCTKASNMGWRYFLIAMGGLALFMCLARCLFFTLYESPKYLMGKGRHEESVAVVHEVARRNGTSSSLSIDDLQDDGPISSSTETTTTTTPTPTNTTPNNGALSALDHLRMRLEPLSAPYVRALFRTPRRAWSTTLMILIWALVGLGFPLYNNFLPYLQQMRGIQFGDGSTYITYRNSLIIAAVGVPGSLVGGVMVEMPRLGRKGTLCLATLSTGAFLLASTTAKTSSALLGWNCAYSFTSSLLYAVLYAYTPEIFETQYRGTGNALVGGANRIGGILAPIIALVSNMETAVPVYVSGGMFVLAGLLVVLIPYETRGRMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVG9</accession>
    <name>A0A8G1QVG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_453606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510872.1">
        <property type="nucleotide sequence ID" value="XM_025661089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVG9"/>
    <dbReference type="GeneID" id="37164491"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH52950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="55" mass="5798" checksum="1EAB15C9E1239ADD" modified="2022-01-19" version="1">MSVLGALFGGVGLATRGGGQPKPATPPIQASSKDEETFIQDFLKQVNGDEKKKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QW87</accession>
    <name>A0A8G1QW87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_461914</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512644.1">
        <property type="nucleotide sequence ID" value="XM_025661817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QW87"/>
    <dbReference type="GeneID" id="37165219"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14654">
        <property type="entry name" value="ZIP_Gal4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000009">
        <property type="entry name" value="C6 transcription factor (Gal4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005600">
        <property type="entry name" value="Gal4_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH54722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="671" mass="75475" checksum="BB86FFB520A78407" modified="2022-01-19" version="1">MASTRDSHSYACDECRLRKSKCSKEKPTCAQCKQLNKECNYSPKVTRSPLTRQHLTYVEERLQAFETALSRLFPGGDLDATVRSLLHDQEGPPKPGSSKSSSRHSTPAKAEPDRAEPAPEALPQQADGFDWAENKITVGDLTDGMAALSIKPEGAGYFGASSSVVPLRALLKHGFDLNIPARSSKSSYGMERVPLKAQLLSTAPSGLVEQAFMDAFFLNYHTSYPFVHEGTFRAQFYEQVPRPHGQAWQILLNTILALGAWSIGDDNSDLDITFYQEARGHLQQVSVFETGNLTLVQALLLLSNYAQKRNKPNTGWNFLGLAVRMAMSLGLHKEFPGWKISLLQREVRRRLWWGVYIFDSGAAKTFGRPILLPEDDVMDAKHVLNIHDEALTPLTTALPHEVNEPTLYSGLIAQARFHLLTNSVYQRLISGPSLTPEETLGLQRPMEEWYNGLPDYFKQPPTPISDAFALVRNRLMWRDWNLRILLYRPILLRWASRRWTPNSAPEPEDPLEADCRRLCLRNARLTISSIADFVNNHVCTRIGAWYMLYFLFQAGVIPIILLMTDPTSTEAPSWLQEIESTKKLLVHPSLSNNRLATRCLEVVNRLCSPAYTSAATDKTAGQTAPILMPFSDQLFNDPTFGSMFPDVDQELNLAGMDFSEWVNFPPQNEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWT6</accession>
    <name>A0A8G1QWT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_470844</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512944.1">
        <property type="nucleotide sequence ID" value="XM_025662429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWT6"/>
    <dbReference type="GeneID" id="37165831"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000354">
        <property type="entry name" value="C2H2 finger domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="110"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="317"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH55022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="424" mass="45002" checksum="D8CEF968F9512758" modified="2022-01-19" version="1">MGKKRRGPTLDELLARPWCYYCERDFDDLKILISHQKAKHFKCERCGRRLNTAGGLSVHMSQVHKEQLSAVDNALPNRSSLDVEIFGMEGVPEDIIQSHNQRVATQFQQAEAERQAVTGNPPPGTGVGGQPAKKPKLESVSDLKKRLAEHKAKKAEARTGGSSGEATPVGAGQTPTMGGFGQPAPAAAAAPAAAPTTTSQFSYPQPYGTASPYPQTASPVYPNFSPGQPQFPPTAQYPPAGYSPQPFQGTPAASFGTTPPAFPAQTPATHTPPQTAGAFPPRSGSLPMPPGLPQRPAVAAPPVNAYQMQQMHMGQAPALNGGETTQAPDTISTSVDDLISGAAKQAETTADKPKSEEKPKKDKSKAVRLVYSDNETSPEEKMAQLARYAFVPEQKGETVLEEVPASVVTGTTREMDTVEDAADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX77</accession>
    <name>A0A8G1QX77_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_428168</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512176.1">
        <property type="nucleotide sequence ID" value="XM_025658197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX77"/>
    <dbReference type="GeneID" id="37161599"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000022">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="95"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="12">
        <location>
            <begin position="349"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="14">
        <location>
            <begin position="622"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="13">
        <location>
            <begin position="838"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH54254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1212" mass="136137" checksum="984B4BD4745DE6EA" modified="2022-01-19" version="1">MQSSPNMLTKFESKSSRAKGIAFHPKRPWILVSLHSSTIQLWDYRMGTLIDRFEEHDGPVRGIDFHPTQPLFVSGGDDYKIKVWNYQTRRCMFTLNGHLDYVRTVFFHHELPWILSCSDDQTIRIWNWQNRSLICTMTGHNHYVMCAQFHPTEDLIASASLDQSVRIWDISGLRKKHSAPTSMSFEDQMARANPAQADMFGNTDAVVKFVLEGHDRGVNWVSFHPTLPLIVSAGDDRLIKLWRMSDTKAWEVDTCRGHFQNASACLFHPHQDLILSVGEDKTIRCWDLNKRTSVQSFKRDLDRFWVIAAHPEINLFAAGHDTGVMVFKLERERPASAVYQNQLFYITKEKHVKSYDFAKNVETPPMLSLRKLGSPWVPPRTLSYNPAERAILVTSPTDSGVYELIHLPRDATGAVEPTDVKRGQGSSAVFVARNRFAVFSQGNQQVDIKDLSNSTTKSIKPPAGTTDIYFGGTGCLLFITPTNVVLFDIQQKKQLAELAVSGVKYVVWSNDGLYAALLSKHNVTIVTKSLEQVSSLHETIRIKSAAWDDAGVLLYSTLNHVKYSLLNGDNGIIRTLDQTVYLVKVKGRNVYCLDRNAKPRVLEIDPTEYRFKLALVKRNYDEMLQIIKTSSLVGQSIISYLQKKGYPEIALQFVQDPQTRFELALECGNLEVAIEMARELDRPKLWSRLGAEALAHGNHQTVEMAYQKQRNFDKLSFLYLSTGDQEKLSRMAKIAEHRGDFTSRFQNAIYRGDVEDRIQMFKEVDQYPLAYLTAKSHGLTEEAESILDACGLTEDQITLPSIEEPARVPHPIVPTFKSNWPVKAAGHSSFEKALLGEVGAGDEEAAAIEFEPEEEDEAITARDTLEDEEEDVAGWDMGDEINVEEDVDFVNVDSAEAGAGSTEADLWARNSPLAADHVAAGSFETAMQLLNRQVGAVNFAPLKPRFLEVYKASKTFLPATTGLPPLVNYVRRTVDETDSRKVLPIIPKDLETIANVDLQEGYAAMRANKLEDGVRIFRNILNSVLVNTVSSEAEVEQAKKIIETAREYILAMSIELERRSIPTDTPDNLKRSLELSAYFTIPKLEVAHRQLALMAAMKLAFANKNYSSALSFANRMLANGGSPKLLEQAKKIKLQCERSPQDKIDIEFDQFAEFDICAASFTPIYGGSPSVSDPFTGAKYHEQYKGTVCRISQVTEIGAPASGLRLFVPGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX94</accession>
    <name>A0A8G1QX94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">12-oxophytodienoate reductase opr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_499896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512598.1">
        <property type="nucleotide sequence ID" value="XM_025664089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX94"/>
    <dbReference type="GeneID" id="37167491"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF129">
        <property type="entry name" value="FLAVIN OXIDOREDUCTASE HXNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="4">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH54676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="384" mass="41497" checksum="278F4B02086389E6" modified="2022-01-19" version="1">MGSITPIDNLFHPLKLGSLSLSHRVVQAPCTRMRATQESEGVYVPNALMTEYYSQRASPGGLQLTEATPISRHAAGYPGVPGIFTPSQINAWKDVTSAVHAKGGLIVCQLWHVGRATVPAFIEGQTPLSSSDIPMTGNALTGEPYAATPPRAMTIPEIQATVAEYAAAATRAIEAGFDGVEVHAANGYLLDQFLHDNVNTRTDEYGGSAEKRARIVIETIKAVCGAVGADKVGVRLSPYNYFQDTRDSNPQDNWQIICQMIARETPEIAYAHMIEPRFDEVLDEGAKMVSLPGKGKVSLDPFRAIFKQTGIGFIAAGNFDGEGAKQKVVEDGADAVAFGRWFIANPDLPKRLMEGAQLNKYDRATFYGADPKEKGYTDYPALSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXN4</accession>
    <name>A0A8G1QXN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_451245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513379.1">
        <property type="nucleotide sequence ID" value="XM_025660547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXN4"/>
    <dbReference type="GeneID" id="37163949"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clr5" evidence="4">
        <location>
            <begin position="4"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="341"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="436"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="581"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="711"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="932"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="967"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH55457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1072" mass="118269" checksum="4EE08C816C7E5FB8" modified="2022-01-19" version="1">MADAIWESYRPELERLYIHEGQKSSEVREYMRTKYGFDERKSQYEKYFKRWNLRKNHSLTSAEGKFIGRRIDKRKREHQKESEVYVDGVQYPPSKLKKSRYNTTFVSTVDNLPNAPSPRTPEGIVVCTPATPGMRLIWKHSLPWLQFSKLLEPRRDDNPSSLPSVLSVTSPQSPGALTNNINRVLMQRLGSIIPWKTLSHPPNINSLSRIVTGLSILMPEEFDGQHRTLATRLCNTPRTTTESLNLELFLLSNNFVSHCPTGKYKSTMAAHDRNVMELFHASGWKNMKHIEILLSTREPTAEAIAEKLFASALRLLDLDTVKMMLEAGMDPDSRVDTSHDGPLTCLQFAAQMASLGIEIVELLLSHGADINLSYNDCLPLEYALRCKNSETVRLFLSHNAIITPSCLATAAEISDMNLFIEILDRVTDVNVPYDGDGLNPLVWAVACGNLSTVNLLLSRGADINALCYIKFDKGLKKTTVLGFAVRRKNLAVIQAMLQSGVNVDPRLVGFPYVSPLTLAVEAKDTEIAQLLLNAGFGIQSASEGWGLSLLERALKQKDMKMSRFLIECGAQTHMLYSNKQQNSSALFLAIQNGYNDIVDMLVQAGAPLNEVYGDAPGTVLAAAIEKGDLMLIHMLESAGATLIGPKLRGIGNLELAMYLQERGVLEDILEVCGGRVLTRAISTGKPGLAHWLLAYRLNVDGHPTMLDMSEHSETPLQAAIKAGSLSFVEIIMARGARVTDCDLAAAVHVGDIDLLSHLLAGFVGRAPTAIGYAIVTGEKEAIKLILDAGIEPTGTPQEFRQGWYNEEDADFALEDPQSVLELAAQQDDRSTLQILLQYRVWDSQIIGRALTVAVVCQHTGLIDDILEQVVDMNQEIKIYYYDWVNENGEEIPEWCEILTPLQAAVKNQLVSIAQRLVKNPQTNIDYLGKGAGGRTALQHAVNNGNMDLINLLLDHGANVNSAPSEDGGATALQIAAIQGYLGIARKLIDLDADVNAAPAENYGRTALEGAAEHGRIDMLRLLLDEGASLVGNYGERQYRRAVELAEKNGQMAAAKLLKSFKDKVEESVFELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXS1</accession>
    <name>A0A8G1QXS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_523604</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511227.1">
        <property type="nucleotide sequence ID" value="XM_025665366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXS1"/>
    <dbReference type="GeneID" id="37168768"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="355"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH53305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="522" mass="58267" checksum="53EA0F22810183BB" modified="2022-01-19" version="1">MATAAGSFRHQDYTVAWICALPLEMAAAAAMLDERHYDLPARPNDGNTYILGRIYGHNVAIACLPSGVYGTTSAATVATQMQSTFESIRFGLMIDIGGGVPTGKVDIRLGDVVVSKPTRDSGGVIQYDYGKTVTGGRFERTGVLNKPPPPVLLTAVSRLQAEHELGPSRIPALLSEAVDRNPRMREKFAYRGRLVTRPTRASHDPVIHYGLIASGNQVVKHGHSRDKLARELDILCFEMEAAGLMDNFPCLVIRGICDYSDSHKNKQWQEYAAAAAAGYGKELLSVVHASHVVDTLPAGSISDVSYCREKPPSMKLPNSEIVRNYGQEGAGLLERISNYEHERIHQRLTRKRLTGTTHWFLDHPDFKAWFTEKRVSSLWCSGKIGSGKTMIATAAIDAAKYELGCPTVAQHLVWDNIPKSAIVCSFKANTFLKLTRIEPCNRCKYRKVSLQTRGVLRELPKYQPRNVQILVDEEKRRILGRFLRRCEDRYYSLNSRLDPPTMLHTADKDEDEEISMMCLFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXZ3</accession>
    <name>A0A8G1QXZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MAGE-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_402707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512864.1">
        <property type="nucleotide sequence ID" value="XM_025657201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXZ3"/>
    <dbReference type="GeneID" id="37160603"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="67"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH54942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="351" mass="39517" checksum="11989EC1415D4E39" modified="2022-01-19" version="1">MAPARKRRAVPDSPSEEDDVPTPATQRRRVAAAHSGDDGDDDDDDAGSDYAYDTRAPSSTDVMVKKMVRLALASEFSRLPIRRSDISVKVLGEQGTRQFKTVFEEAQRVLQEKFGMEMMELPVKEKVTVQQRRAAQKVEKPSSTNKSWIVTTTLPTKYRKPEILLPSRAPMESTYTGLYSFIIAVIVLNGGTIHEQKLERYLKRTNTDAWTPIDRTDRFLQRLCKEGYLVRNRDVDGGEEVIEYILGPRGKIEVGTKGVARLVREVYGQSEGSERDDEFEIRLARSLGLKQPEPRAQEEQAEEGGGGGGGGGDGEEDGRQRQRREQPSRRVNRRLPESEDEEESEEEESDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYB6</accession>
    <name>A0A8G1QYB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_451588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513168.1">
        <property type="nucleotide sequence ID" value="XM_025660622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYB6"/>
    <dbReference type="GeneID" id="37164024"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
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        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
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        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="793" mass="88352" checksum="37DDD5C3AE463C9B" modified="2022-01-19" version="1">MSDSPRPVQRRKKRDSTLQAVDLLNGLMDTNTQRTASGANRPSPATPHPSRRLTYSVRRDATDMIDEVGPVSQTVPQRPRHAHPIEVTPRRSLRFSKPVPDGSTRDGSDQMLQPPKSPESKHESGDQSNEPGEVQSLEKAEEGFGDVTHVVSPRPSSEEYSSSDAERDNEGDHISSQNDEEMLDGEDLASEVELFSNNDGDAHQSTSRPSLSPSSSQETPGRKPKTQSGSDETSEPTLVESNEDTSNVQWRDASEQPADRRDSSRSDASATKGLPTIAVEISTATPLSSNISKTVDHQADGPSRDNETRTLEQEANIFGTTQHKDPPYQPSEASSSSVPSPEPSSSKDDLQHHFAEASPRSSDPPRQSTKRRHSTTSSQGTARVKNIEPEHPTSTAHQQAGSFIPRESPADNPQRSREASHRGERHATEVASPGVIARSATQDGPTQENPDQQSHGAERPEDSAWFKEASELDSQGSNWKKLIQSMHPRNIAFNAKRVDIEFEPLKCELSSLIQAYKGIIEYLASDIGPPEYDVRSCSSMLETVDRQGRRQLEKAYTLSTQGDEAGGRALVEEFEIQIFPLLVRLVLVCFEAYYVDHRLFPEAYGHFQHAMKVLLGRCNQIGGLVRGKYVACRAVSPGLRLPLKRLLESLENGRLRKGHRRNDVEVDRHAKAPTRTAKQGQSKPTKPTTPAQAWTDEEGYALVEGLQRFQGKFQAHLLGRKEGAARHAHKMHLGPDRYYQICEFYHDGIGQRGEREVREQSERLCHQMLPQIREMARRGEDHWDWGWLLKVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYM4</accession>
    <name>A0A8G1QYM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane ATPase</fullName>
            <ecNumber evidence="10">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_469591</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514245.1">
        <property type="nucleotide sequence ID" value="XM_025662339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYM4"/>
    <dbReference type="GeneID" id="37165741"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000021">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="733"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="758"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="792"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="858"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="909"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="84"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH56323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="984" mass="108366" checksum="8C32055CD58DDAB7" modified="2022-01-19" version="1">MSTNGDVERDASSRRASRFSSRSARSDTKLDEYTRLVKFMSTYREKDANDPGEGEIRESRVWYAPWKKRRFRWKHVGSSREFPEEWRLTDIHHGLSGSEVETRRRSAGFNELSSEKENPVARLLSYFQGPILYVMEIAILLAAGLKDWIDFGVIIGILCLNAAVGWYQEKQAEDVVASLKADIAMRSTVVRNGEEQDILARELVPGDVIIVEEGQTVPADAKVICDYDEPDQGWSEYQRLRSEGRLEKDAEKSNDEEGEDDSDDDEKGYPILACDHSAITGESLAVDRFVGDQVFYTTGCKRGKAYAVVQATGTKSFVGRTASMVQNAKDTGHFKMVMDSIGTALLVIVMAWLLAVWIGGFFRNIPIASPGEQTLLFYTLSILIIGVPVGLPVVTTTTLAVGAAYLANKKAIVQKLTAIESLAGVDILCSDKTGTLTANRLSIREPFVSEGVDVNWMFAVAALASSHNVRSLDPIDKVTILSVNQYPKAKEILQQGWKTENFTPFDPVSKRIVANVSLNGTRYTCTKGAPKAVLSLTNCSEETARMYRQKATEFAQRGFRSLGVAVQKEGEEWTLLGMLPMFDPPRDDTAQTIAEAQKLGIKVKMLTGDAIAIAKETCKMLALGTKVYNSEKLISGGLSGAMAGELVEKADGFAEVFPEHKYQVVEMLQDRGHLTAMTGDGVNDAPSLKKADCGIAVEGASEAAQSASDIVFLEPGLSTIIDSIKATYIQYRIALCLHLEIYLVTTMIILNESIRTDLVVFLALFADVATVAVAYDNASYELRPVQWQLPKIWVISVILGILLAAGTWVIRGTLFLPDGGIVQNWGSIQEIIFLEVALTENWLIFVTRGSSTWPSLPLVAAILGVDILATIFCLFGWFSNRDMITDPYDQYISKETSNGWTDIVTVVRLWGYCIGVEIVIALVYYVLNKIAWLDNLGRSKQSKGDAAIGNVLAHMANLSLEFERGENGNGRVFLASGKEEEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYY1</accession>
    <name>A0A8G1QYY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_461912</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512642.1">
        <property type="nucleotide sequence ID" value="XM_025661816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYY1"/>
    <dbReference type="GeneID" id="37165218"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.20:FF:000003">
        <property type="entry name" value="Ubiquitin thiolesterase (OtuB1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="8">
        <location>
            <begin position="119"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH54720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="486" mass="54296" checksum="DCDEC843F3219008" modified="2022-01-19" version="1">MSLSDLPWNRFDPINHFPTGQDSTSGFYPQHPHSSAFFDHGYSQLSNALYHPGNNFFFNMNTLSTAEMERFQKLSNEFQPDVQGPPVSTKQSSSVIAMEYANADPTFATKTNALALTHPLTRTMKGDGNCGWRAVAFGYFENLLNLQNPMQVHHELMRIKAMNALLDQTGQEEHLYEIFVDATEEVFNQISTAIQNGIRDETFLVNAFNEEYNSNAIITHFRLLTSAWMKLHPSRYEAFLSMPLEQYCATRIDVVRTEIDEIGLQALVDGVIEGSGFAVEIMYLDRSEGEAVTPHLLTPPRATGGTICLLYRPGHYDLLYPAEPTVNMEPVVNYQYAMTSDYAPWDQGALAFDVNSSLMTIPNLMMDPSFGMAPSPMPAAPPSPYRVSPPQEVYQPPPMHASPPMSIASPPPAPPRMSAPPPPMSSLPPRSSDGPQIRLNPLVMKPNLSHSLPVTTPFKNSSPYNQAHFQNQDFEPIHWEPSDSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ17</accession>
    <name>A0A8G1QZ17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SNF7 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_61107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514114.1">
        <property type="nucleotide sequence ID" value="XM_025665526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ17"/>
    <dbReference type="GeneID" id="37168928"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="26119" checksum="AD8C9EDE95389469" modified="2022-01-19" version="1">METLKAVFFGPDPQTQMRKCNQLIRANTRQLDRDIAQLKTLESKTRQYIMNSSKRAQRNPSQAKQANMEAKTFARELVRIRKQSTRLHTSRAQLQSVQMQVNEAFSVRKIQGSLKKSTGIMKDVNTLVRMPELNATMRQLSTELVRAGIIEEMVDDAIPNNELLEEEEEEAEEEVDKVLQEILHGKLSQVEGVQPEKPLEEAPEPEDEFADQEATLEQMRGRLEALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ40</accession>
    <name>A0A8G1QZ40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCA7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_401828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513558.1">
        <property type="nucleotide sequence ID" value="XM_025657171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ40"/>
    <dbReference type="GeneID" id="37160573"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="136"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="343" mass="37010" checksum="DC8D9752BED6EF1C" modified="2022-01-19" version="1">MAAFPTGKPREEDHLETVICKTCKRPVLKQNAVEHIRGCIRAKQEKARKKKEARDAANRAKEKGDKDGDEDVGAGEKGEGGEDSMKGQKSAKKSAVKGMAEDGTKKGKKRKTEAGEDDKDKEPKKKKKKEEPKPKVPKPKGPVDVEKQCGVTLPNGAQCARSLTCKSHSMGAKRAVPGRSLPYDMLLQAYQKKNQARQQRLVSTEAAIDANAPLQDDLDNNGPVDSDEEKDTVMAAISRSHPYPMVTHTLISTKKKYQYVRIKEMLSHALGGSRGGGLFSTGDTLSSPFPDGGSLFTPVEEVSVPEPMVVDEPEPAETQENATDAGAKTPAPEAKQVPVAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ81</accession>
    <name>A0A8G1QZ81_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_471653</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH54010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511932.1">
        <property type="nucleotide sequence ID" value="XM_025662490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ81"/>
    <dbReference type="GeneID" id="37165892"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="212"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH54010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="637" mass="72383" checksum="3D769859DAAF6F95" modified="2022-01-19" version="1">MNDTEEHSSADDNNPGPAPHGRLGHIVETADGYSNDMSLSPNYTEGAGISFMSLLFTDPRWREQNQKLLHNLSKRATILETSVQQNSLPSAEEALVVFDSYLGTSHVQNPFLLRRYVQDLYRALFPESLEDQHARASVGQTTEHQLFRTFMILAIGAIPLYRAGKHQYHPYGYFLSALKHLEEGFLLKGLESIQDLLLVSRFGIYYHIGTSIWELIQLSTRMCIEQGLHKCRSRKSPDDHLLEEQLRRRVFWQCYMLDRYTSVILDRPPAIADKDIQIGFPADADDEELDLAGQSGVFADIDSFYRIGTAHLDSMHTTETSVFLLCLRLRKITSKIHTRFQQKAKGRAEQEMSQIELATASGTIYLDLDELLNELESWRNSAPVFSNPKCLYERQEWYDLLLMRERLLIIRKAIDLVPKRNNVPPQDLLSICLEFSVGTITTFCAMFDQGFVTYTRSYFQTLFTAGLSVMFCVSVVEDLDYQTIKSASEAVKKGEKTLKLMVQELPDAVHYVALYEALRADILRKTKNQRPDAVHGEQHIPFDITHQSGSIQFLLDGSVNTENEPPAPVSEHNPPWPILTPDASTNEAHLIQLQEAAIENQQLSWDIFGDNVFWSMEAGMLGEYVYGSSAAGHFLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZM7</accession>
    <name>A0A8G1QZM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_375936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513843.1">
        <property type="nucleotide sequence ID" value="XM_025656197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZM7"/>
    <dbReference type="GeneID" id="37159599"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="37802" checksum="C5EB9D05C443A5EE" modified="2022-01-19" version="1">MTSKELFTQILHKHHKSLPISEKESSCHGVIYLIENTIAAGRALKSPNESLIDRAPVRPPFDLTGTLSSSSNGTQRKGLAHSPDPFRKNPGKTIQELPKSLGLPQALKSRHSTSSTLIVRDDESPWDNFEPAFHCRLAGSIVVCVQQTRPFQTAAKREYAMENTERIHGLYQQLQHENILSVKECYTDNSRFYIRVDDLPVTLEHLVLNGLFYLVASGFEHTALTCSNILLGSDRTVKISKTGPFLACHKSMAAIMMQPMHKYEKKNGVIGVDNLRHWPLDLFAVDFLTTTSSARSIKILKQHSFVMENNRARGNSIGLARLALITTKTFYSMIINM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R012</accession>
    <name>A0A8G1R012_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_479253</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513676.1">
        <property type="nucleotide sequence ID" value="XM_025662940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R012"/>
    <dbReference type="GeneID" id="37166342"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="198"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH55754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="577" mass="64724" checksum="E3E0FEA3559220D9" modified="2022-01-19" version="1">MGVITLSDSATFSSYFGPSSNVALVYELTRVLKKLSGAPVNLSNTRAEGVEANNNQQSSLTSSPSLIPRVMTAAGAQSLPPEPEATSLLHEYFDTIGLFFPCIYRDTFLAKYRDFRRNESSHASRSWRALLFVMFAVMYQMRSFASPTDAEDKLSWEYLQKALNLAMPEAVIDSDLETVQLLCLLTCYLQCSTNSAQTWSFHVLSVKAAMQIGLHSLEATQNLPLLQRELCKRTWFWCVVNDTLVSVYLGRPPVVPKSLISKDLPEDMSDIFPTSNQSRTVAMTSLAYYNAKIRLAMIISDILAQLYGDNMAANNSMGVFETLRSAFDLSWKLSEWRSSVPAEIRPGSVIAAPEIPRALQMQRFQTGLSLYFHAAQALIYRPVLLRFLQYKPAGTNATETLSLLKDSGFSTIKKCMHTCSRGIELAKIIVDEQFLPTSLWGAWWMTNFLVFNASMMHFGMLLISTQSSFSGLMATEDIDLILSDLKDASEVHRRLNRNNLIISRCRECLHNFLDLYKSFRDTTSPNGVGEWEDLTFSLQQPDFQIVHASQTATSSILPNPGQDFVWFDMEAFPGPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R051</accession>
    <name>A0A8G1R051_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_441448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512427.1">
        <property type="nucleotide sequence ID" value="XM_025658806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R051"/>
    <dbReference type="GeneID" id="37162208"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="141" mass="16997" checksum="E3C97AAD86AFEC49" modified="2022-01-19" version="1">MPSDSNTGASTSHEHDGNGRRSGRSSDRDRGGRGGWRPRRSYIKILIEWRQRLQRRHYRHRQQYQGQGQHYQDHRRQDHHNHNQQHQHHQQQAQQQQAQQQQAQQQQAQQQQAQQQQAQQQAQEHSELQEQQEQQQEQKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0A8</accession>
    <name>A0A8G1R0A8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_449743</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514931.1">
        <property type="nucleotide sequence ID" value="XM_025660221.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37163623"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000007">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000009">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.730:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022365">
        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01394">
        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="541"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="690"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="838"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="984"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1133"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1279"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1428"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1622"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1622"/>
            <end position="1636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH57009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1679" mass="190858" checksum="33F217016A922942" modified="2022-01-19" version="1">MAPLPIKFTELLNLTNAEIAPASIGFNSCTLESDNFVCVRQKLTEEDKPQVIIINLKNNNEVIKRPINADSAIMHWNRNIIALKAQGRTIQIFDLTAKQKLKSSVMNEDVVYWKWFNEKCLGLVTESSVFHWDVFDPTQTNPQKVFDRLPNLSGCQIINYRVNDDEKWMVVVGISSQGGRVVGSMQLYSKDRGISQFIEGHAAAFASIRVEGSPLEHKLFTFAVRTQTGAKLQIAEIDHQEPNPRFQKKAVEVYFPQEAVNDFPVAMQVSRKYDIVYLVTKYGFIHLYDLETGTCIFMNRISSETIFTTAPDSDSAGLVGVNRKGQVLSVSVDENTIVQYLMENPAMSGLAVKLASKAGLPGADHLYQQQFDNLIAQGNYSEAAKIAANSPRGFLRTPETINRFKNAPQTGQGMSVILQYFGMLLDKGSLNKYESVELVRPVLQQNRKHLLEKWMRENKLEGSEELGDIVRPYDMNTALAIYLQANVPHKVIAGFAETGQFDKILSYSKQVGYQPDYTQLLQHIVRVNPEKGAEFATQLANEESGALIDLDRVVDVFLSQNMIQQATSFLLDALKDNKPEHGHLQTRLLEMNLVNAPQVADAILGNEIFTHYDRPRISQLCENAGLIQRALENTDDPVAIKRNIVRTDKLSPEWLMEYFGRLSVEQTLDCMDTMLQVNIRQNLQAVVQICTKFSDLLGPQQLISLLEKYRTAEGLYYYLGSIVNLSEDPEVHFKYIEAATAMGQITEVERICRESNYYNPDKVKNFLKEAKLTEQLPLIIVCDRFNFIHDLVLYLYQNQQYKSIEVYVQRVNPSRAPAVIGGLLDVDCEESIIKNLLSTVDPSVIPIDELVSEVESRNRLKLLLPFLEATLATGNQQQAVYNALAKIYIDSNNNPEKFLKENDLYDTLTVGKYCEKRDPNLAYIAYRKGQNDLELINITNENAMYRAQARYLVERADSEIWSFVLSENNMHRRSLVDQVIATAVPESTEPDKVSIAVKAFLEADLPGELIELLEKIILEPSPFSDNGSLQNLLMLTAAKADKGRLMDYIHQLNEFSPDEIAEMCISVGLYEEAFEIYKKVNNFIAAVNVLVENIVSIDRAQEFAERVELPEVWSKVAKAQLDGLRVSDSIESYIRAGDPSNYNEVIETATHAGKDEDLVKYLKMARKTLREPAIDTGLAFCYARLDQLSELEDFLRTTNVADIEASGDKAYEEGYHQAAKIFYTSISNWAKLATTLVHLEDYQAAVECARKANSVKVWKQVNEACVNKKEFRLAQICGLNLIVHAEELQDLVRQYERNGYFDELIAVLEAGLGLERAHMGMFTELGIALSKYHPDRVMEHLKLFWSRINIPKMIRACEDASLWPELVFLYCHYDEWDNAALAMMERAADAWEHHSFKDIIVKVANLEIYYRALNFYLQEQPLLLTDLLQVLTARIDVNRVVRIFQASDNIPLIKPFLLNVQTQNKRAVNDAINDLLIEEEDYKTLRDSVDNYDNFDAVALAQRLEKHDLIFFRQIAANIYRNNKRWEKSISLSKQDKLYKDAIETSAISGKSDVVEDLLRYFVDIGSRECYVGMLYACYDLIRPDVILELSWRHGLNDFTMPFMINFLCEQTRTIEMLKKDNEERKSREVTQKTEEDNTPILGGTRLMLTQGPAAPAPSPMAFGQANGITPQATGFRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0R9</accession>
    <name>A0A8G1R0R9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP synthase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_290225</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515878.1">
        <property type="nucleotide sequence ID" value="XM_025655257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0R9"/>
    <dbReference type="GeneID" id="37158659"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000006">
        <property type="entry name" value="ATP synthase subunit 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF13">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0138">CF(0)</keyword>
    <keyword evidence="9 17" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 17" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="18">
        <location>
            <begin position="92"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH57956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="157" mass="16660" checksum="2F87D7A6C11B6F8D" modified="2022-01-19" version="1">MASSRVFAQRLASTMAASTKVARPAARLQLAPKRTFTTQRKAVPMTPFQTVKRQSPSGLIQANARQAFAAQQARRQYSSEIADAMVQVSQNLGMGSAAIGLGGAGIGIGLVFGALLLSVSRNPALRGQLFSYAILGFAFVEAIGLFDLMVAMMCKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0V5</accession>
    <name>A0A8G1R0V5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_424413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513647.1">
        <property type="nucleotide sequence ID" value="XM_025658042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0V5"/>
    <dbReference type="GeneID" id="37161444"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH55725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="308" mass="35178" checksum="836D799E6A6758A1" modified="2022-01-19" version="1">MSATVQTRVVDLDQLIPRVVKKDVEILLPWVYDQANIARGTHLFDWPDEDHEFRFLFEQFFAYQIALTPKSSSSIGPITSKGEITLPRMNWKVAGRESHRYFVSSQGFILRILMQMVHRKLKRVMKPEQTQGLEIRSPNLISSSSKYVIGRQMYASRPVGQVTVGPRDNSLPIISYTGWFEGQTWEGFVGEVLSVMLGQLAKTFTIHKHNQGLQDQEVFVVGFYGPHIYIARGHFPTDEISRVHSKGLSGNESFELEFTRGYNPCQKDDWLEAMRALTRLFRYLLSGTSKVSAMQCFLLKSTSTAEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R157</accession>
    <name>A0A8G1R157_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_307674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515565.1">
        <property type="nucleotide sequence ID" value="XM_025655394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R157"/>
    <dbReference type="GeneID" id="37158796"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42977" checksum="D3E31C7BFC954CCF" modified="2022-01-19" version="1">MLIQRPYLDVHFQLQPGSADFSVGDDIKGTAYIIPRKSISPHQLSIYLEGKVKIQIDRTENAVPLPPYTACQTFLRIEQPLELKSSTDSELLQGGLRHEIPFGFKVPPRIRGSVCQQFCHHQQVQKEHSLLPPSMGQCDMTPSEISVEYNIKLSLTRGINRDGMPAVAEWACPLFIRSPRIEQAPLLVPEDSKHYCLSKEKFVSKSPISLSRIGALLARTAQPAAIQQAKAMVRYLPVDLQFQTISEPHLPQLSSMCVSLNAITTFGERAEIHLPEAIGSSARDPYRHSYVQTVSLGSSTPSPLEWEKRHFTEDPDSSTASIASGIIYSTSVKVPIKLPESLSLPPTFSYCLVSRIYSLTVTLRFLIQGQWGRTTSLILTVPLQIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1D4</accession>
    <name>A0A8G1R1D4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_477883</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515299.1">
        <property type="nucleotide sequence ID" value="XM_025662857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1D4"/>
    <dbReference type="GeneID" id="37166259"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="30"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH57377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="373" mass="40719" checksum="239A3901407A7521" modified="2022-01-19" version="1">MGSSITNPSGLALERGMWAAVAIATFILILRIIAKIKIRNFRIDDVLMIIAWALTLASTVILTLSVQNGFGTNLTKLPFHNTSKVLKYISFEVLLVTLSTGIARSSFVLYLLAILGGKKKYCVALWIVMLLQLSANIVSAVLPLSICRNARVLWDPTVKTTCGSSVAVVNFSYFSSTVNSATDLFLAVFPTIIFWNLNLKLRIKCQYINGFTYCPVSLHRTSAMVASIIKTTKLKEVPSITNLGAGGAVELIRWGFSENLIIIITSSVPCIRPLLISSVRKLSSAARSRSYELSGPLSGQKGTAKNGTFQSHAQEQPSTDNRDDCDSIEQILKDSYHSGSMVESGRGIKKQVEISVVSNQKGSRWGSDRTSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2I4</accession>
    <name>A0A8G1R2I4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_448817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516763.1">
        <property type="nucleotide sequence ID" value="XM_025660028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2I4"/>
    <dbReference type="GeneID" id="37163430"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22952">
        <property type="entry name" value="ART10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="417" mass="46723" checksum="B62F0E44F521FE42" modified="2022-01-19" version="1">MPITVSLINQQQCYAGNDRIRGRIVFQCSTPTEIQDIRVTFSGRAKAKVQKTKGSAAPAASYRSKCMLFEKERILWHPNGDTVAPDTYEWPFEFVFPSHVQPASSRWPETLPFRSDANHPLPPTFAAQTHDSLRKLECTIEYRIHAQVFRPQRGILGRKSPLFSEVIRLNFLPLEARLEMKGTDDYPTTYQQQKEQPFNIRSMLLLPENRGRNLKVQEKIQSWLSPGQLPRFSFKASFSYPTRLVQSTPIPCFLDITPFMEDSSVTSPPDIVMQSLSISMVSQTAARAAPSLMGALSGQVDERIEILSRTSLGMPIMGKVDLAQAFGPLRIRNTDVSFRTFNISRTYRLCASFSFECAGKSSTFDIPDLPVELLANSRESEKATQSFEGYVAEAESPPPYASASTLSTSSITTPEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2X1</accession>
    <name>A0A8G1R2X1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_448492</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516356.1">
        <property type="nucleotide sequence ID" value="XM_025659944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2X1"/>
    <dbReference type="GeneID" id="37163346"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF15">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH58434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="336" mass="37940" checksum="D7CABDFC2E155483" modified="2022-01-19" version="1">MEYQRLGKSGLKTSKIILGCMTFGNPAWEGSPWVLPEDEALPLLKKAYDSGINTWDTANSYSNGTSEILIAKALAKYNIPRSRVVIMTKLYYPVFDPDSPSRPNPAINDGELVNQMGLSRKHIFDAVEGSLARLNTTYIDVLQLHRLDDTEPEEIMCALHDLVRMGKVHYLGASSMYCWQLARLQYTAKMNSWTTFTSMQGLWNLLYREEEREINPFCRAEGIGLIPWSPLARGLLARPWNAQTYRSSQDKKTVKWFSGEQNEVIVSRVEQLARMKGCSMSAVAIAWLLKKGACPIVGLNSMERIESAGEALRVELSDEEVRLLEAKYRPLPVEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R424</accession>
    <name>A0A8G1R424_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_50398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514377.1">
        <property type="nucleotide sequence ID" value="XM_025664271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R424"/>
    <dbReference type="GeneID" id="37167673"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="499" mass="55814" checksum="AC4996892D61DC0E" modified="2022-01-19" version="1">MSLKDVYQRFLANPASAPLASNASLIYITTTTKLDGASAVVSHLTKQQRIVKTRSENVLDVIESANSLCLDIETTLEFVSGGGAYLPSLDDNFLADHVATFPTVHIVRFNSQNQIQNVRIYWDQASLLKQVEVIGSRSRGWPIREPKDQIRLIKSAISSNPGDDGPTSASFPATTESNEERSKKGSPGKRHIKDPHAAESLFELLSPEKDRSEPVRAPRAPASAKPPPRDPKEIFHEDADIPDTPSRSRIAPKAGASKNFQRSRIFDDDETVAAEGGHEQIAYRANPKRYDHFELGGDNSEREIKEKPSRPVSRQAPHWDFDDFVTPEKPKRPLRGEQIRHFGWSDDEPDLTSPPAHPPVHRPRRDAETHFVLTDDPAEDKNAPRIISSFQNKGLSLYKNHLFQDEEEAAGENAPLSVVNNGPNRKKDYETHWNITAESPQSSKVSSENVKPVGGDRQKALKNMQSSWDDPEQSPEKAAPPQRRAIRHLNQRSWDMGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R567</accession>
    <name>A0A8G1R567_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_421743</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH56995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514917.1">
        <property type="nucleotide sequence ID" value="XM_025657943.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37161345"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="11">
        <location>
            <begin position="613"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="876"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="200"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="981"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1181"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1226"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1387"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1226"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1263"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1295"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1440"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1462"/>
            <end position="1476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH56995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1476" mass="162163" checksum="AFFBC37B221A5A27" modified="2022-01-19" version="1">MLRDELLRSKKDEIARCLSSRKRKLSELYFATVGFAGATENAPADSLYHHKEQAFLDANDLSKGRYFNPATLPPLPDYASILARKAREAEETAAATRPVPAELTAKSHDATASVPQLGAQSAAAQAIATDVERQPKYQKVTEQRPSDHEPEHRVATNQVAPAVASQVSQVSDVSAPAIAHPAQPSATDNKLSTLTTEVHPNVYSNGIGEGSASPAQAQTKPNVDARPSGTPDLSSAQRKDGIRPSLAQGRPVQVPEQPLSPVSSAGPYSNNTPVPVPVSPATSPAEEMNDAPHKIPSPKDEEAVKAPPSLVPSTPDEQLRLEEAQSLQQSNLAAVKTSADEVDGGTVTSEVIQENVVTSPADVKETPKETPELAPALPSLDHKRPDGVIEATDDLRPSTQAGPAPQAEASNKVPTETAPVLKKATPPAHPVPSPPERMTTRVSSGAIRHKSVSEILGEPPKTPVSPSDKGTLPEKPTESARDVSTATPDSAARMRFKDRKAREKERTKLSTVVFPKQQQQQQIQEKSESMEMVRQHAGDLAKINEEQDYLFTLFQNRAYAPPRGTSLSTLLASAHKTLTTSNHFLDYQEQMDCRTLRRIYSLQNANRWPLRQLKRSVEPPREATHWDVLLDHVKWMRTDFREERKWKIAAAKSCADWCAEYVNSDPEHRSLLRIQVKTPSLKIEAKSSMISPPEETGDEMAAISHPTPDLVPSTEEDSVSEGFNDEPRHDLHDTVAPAAIFSLGTDEFTFSLDMTAAAREILDNLPTYTPVTIAPDTNLPAFKEPPDSVWKTEILPVSKYASGKITFHDDEPPPKRSRYDYSQYQSDPEQAVLDLPPEQTNVALFRPENRHIRDRIHPGHSFRPPTEHPMPSVGFFESRQSSQWTYAEDDELRRLVKEYSYNWSLISNCLTPSSQFTSGAERRTPWECFERWVSLEGLPADMSKTQYFRAYHQRLEAAQRTVLAQQQAAQQQQQQQQQQQQQQQQQQQGNNSNPQSVPQVRRRTTQPVRVDRKRSSKHLALLDAMRKLAKKRETMLQKQQHASHLASLRKVNEANQPKPPITSPAEFSRLKYERELKLQERQEQYRQQMIAQQRANLAAQRAGQIPNQQPMMNAPGRTPGGLPHNPGTSAMTGNTANGLPNALPNGLPNGLPPGVGANQARPHMQGMPNATPVNGPMPSNPMAMKMMPQSGIQQNNGARPGMPMQTPPDNTRVMREANRLQEQQRILQTRQQAQPQQHPHQQQAQPQQPQQQFHNQQQFVPQGSHSPNLNMPNVNGTPNNPAMMAALQAGGGMQSPSFHNTTPQGVSTPSPRMAQPNLLSGGVVPTISTIQSQIQRSNPNMPPEQVNKLATDRLHQYQQQRMSQVAMSAAAGNIGSVQANYQIPHEASFQSPQPGLNGAPGMQVPQAQGYSPMMRVPQPAQQNRVGVGSSPAMNGAVPQPSRSVTPQTQRSGSAQAGAVAGTSKSPNPPQAQTATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R671</accession>
    <name>A0A8G1R671_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="23">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">BO85DRAFT_266094</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 23">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:38584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="23"/>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517154.1">
        <property type="nucleotide sequence ID" value="XM_025655054.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37158456"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070867">
        <property type="term" value="C:mating projection tip membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099040">
        <property type="term" value="P:ceramide translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000048">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000108">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 22 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 21 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 23" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1136"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1164"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1215"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1256"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1281"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1321"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="25">
        <location>
            <begin position="118"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="26">
        <location>
            <begin position="1101"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1390"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1491"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1390"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1506"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="20">
        <location>
            <position position="631"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="632"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="765"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="806"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="829"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="864"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="944"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="945"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="946"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1049"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1055"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1075"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1078"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1079"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1079"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="RAH59232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1515" mass="169597" checksum="ADFBA8975A96F277" modified="2022-01-19" version="1">MASIDLGAEFNDSGNDIREVSSNVSKPTKRQRWATQRRAGAGGTRKRVSIVDRLHKKNLDAKEEMPKTSTANSPTSMKSPTSQQTTTSTESPTGSSNRRIYFNIPIPESERDEDGRPMAAYPRNKIRTAKYTALSFVPKNIWFQFQNIANIYFLFIIILSFFSIFGVSDPALNTVPLIVIVVLTSIKDAIEDFRRTVLDNELNNSPVYRLIDWTNVNSTEDNVSLWRQFKKACTRATVQTYRAMKGLVQKNKNSQQQVKDNRRLTYMTTVSPRASMSSQQDEDDAIQMTPVSTPAPEARPDWPLPVGNHDQYLHPDKLARDSLATPTPAAHPPKGGSIVDMSKQTLGNARFKRDFWKNIQVGDFVRLYNGDQIPADIVLLSTSDPDGACYVETKSLDGETNLKVRQALNCGRQVRHARDCEKCEFVIDSEAPHPNLYAYNGALRWEQRDPTYSDTPRNEMVEPITINNVLLRGCFLRNTEWALGVVIFTGEETKVMLNSGETPSKKPRLAKDLNWNVIYNFVILFIMCLICGIGNGIAWGDPDASLDYFDFGSYGSTPAVTGLITFWVAVILFQNLVPISLYISLEIVRTIQAVFIHSDVFMYYDKLGMSCVPKSWNISDDVGQIEYIFSDKTGTLTQNVMDFKKCTINGVSYGEAFTEAQIGIVRREGGDADAVAARAREKLAADTVMMVDMLRKMYDNPYMREENLTFIAPSYVADLGGQAGEEQRKATEHFMLALAVCHTVITEHTPGDPPQIEFQAQSPDEAALVSTARDCGFTLLGRSNDDLIVNVLGEERTYTVLNTLEFNSTRKRMSAILRMPDGSIRLFCKGADSIIYSRLAPGKQQELRKTTAEHLEIFANEGLRTLCIAYRDLSEEEYRVWSKEHDSAAAALTDRDEKLEQVASEIEQNLMLIGGTAIEDRLQDGVPDTISLLADAGIKLWVLTGDKVETAINIGYSCNLLSNDMELIVFNVPGDQLERASQELDNQLQRFGLIGSDAELLAARHDHRPPPPTHAVVIDGDTLKLMLGDELKQRFLLLCKQCKSVLCCRVSPAQKAAVVRLVKNGLNIMALSIGDGANDVAMIQEADIGVGILGEEGGQAAMSSDYAIGQFRFLQRLVLVHGRYSYRRMAETTANFFYKNLVWTIALFWYSFFNNFDGSYLFDYTYIVLVNVAFTSLPVILMGIFDQDVDDKVSLAVPQLYMRGIEQKEWSQLKFWLYMLDGFYQSIICFFMPYLLYSPSTFVHSNGKDVSDRTRMGVLVGSSAVIASNTYILMNCYRWDWLTVLINVVSSLLIFLWTGIYSSLEASTTFYNAGAQVYSALSYWVVLLLTVTICLLPRFTVKAFQKVFFPLDVDIIREQVSQGKFKFLDQYEGTVPPRAAAAAAAGSTAFSDESSTSSDFVKPIQPSLKQDPFSDEQQIYSPSIVPTIHTHRPRGSNGTNYASSLDTTRLPHAQPVDYIHQSSERTRHSFERVQHGFGVPHDYSAGELTRESSFAGAQEPHSPLHGAHDPPFHAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6P2</accession>
    <name>A0A8G1R6P2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_458854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516617.1">
        <property type="nucleotide sequence ID" value="XM_025661609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6P2"/>
    <dbReference type="GeneID" id="37165011"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF4">
        <property type="entry name" value="ACETAMIDASE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="632"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="675"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH58695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="800" mass="90507" checksum="4A0371C85D39FD86" modified="2022-01-19" version="1">MTSAAHSSHPPAGNGVTKRKSGSAACVHCHRRKVRCDARIVGLPCSNCRSAGKTDCRIHEKKKRLAVRSILDPVPIRCRPPPASSEPLHRHSLPLTATTPPDAFTTTFRGVQPEVTTPVAPPTSSLHNLHQTLNHNVNQHPPHNGAGSTSESPTYNRPPGPDVSAESDSHADLEKRLVKLIDEEESGSREIRRGVRAIYVGHELSNMSFLIRQQRDKDDDVYHFAGNEIPRRQLRTGHDQLLMDALTLPEPALADELVQAYFDHVNPGYPIIDEDLFMAQYRNRDPADPPPILLLQAILLVGAHVTRPKAERDALKDIFFRRAKWLFDSRIERNRDILVQAALLLTWHSDGADDDVAANAHYWVGVAARIATGLGMHRNPISSRFVSRDRRMWRRLWYIIVQFDVMVSLSYGRPQAINLEDSDVSPLTISDFEGCGPRVQSDYVIHFSELSVMISYIVRSRFGLRVSPERRKAVLLEADEALANWSLKLPDKLRLRASDMDPWSAMLHLTYNNFLILLHRPHPRASAYSDDYGPHDAEICSAAAGVITSIFEELRLNDRLKFLWYSGVHTLFTAMIQVRVELRFSNPVLAINALRRFDSASYSLRELASYWFHANTILRLFEDSRRLQEDLRMATSERPPRRFSNPQDQLKTTLHSATSTSTSAPTTMQTTRTPNPNPTDRPLPFEVPTPDSSTNHLPTSPHHNHPQPQPQQQPHHHHLDAWIPPPPPSATMTPVVDAIDADAPRESLDWRQLFSFTDLDQPVLPMAMEGLPELEDEWRQIYWQETPMSDLLLDGGWMHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6U6</accession>
    <name>A0A8G1R6U6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_446813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518194.1">
        <property type="nucleotide sequence ID" value="XM_025659585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6U6"/>
    <dbReference type="GeneID" id="37162987"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052777">
        <property type="entry name" value="Acetyltransferase_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43305">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43305:SF1">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="173" mass="19173" checksum="E94880DA8F96094B" modified="2022-01-19" version="1">MPPTYQIISATTPHHLLAARTLFTAYAAWLNIDLTFQNFQAELSSLPGKYSPQEGGDLLLAYSSSADTSSSPLGCVALRPLPVKDDERQQLCEVKRLYVAPEARKMGLGRALVSAIVTRARELGYRGMRLDTLRSMEGPIRLYRSLGFVEVGPYYETPLVEETVFLGLDFAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6U7</accession>
    <name>A0A8G1R6U7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_467973</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517261.1">
        <property type="nucleotide sequence ID" value="XM_025662224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6U7"/>
    <dbReference type="GeneID" id="37165626"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="38"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH59339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="489" mass="54895" checksum="E53E54D42EA7254D" modified="2022-01-19" version="1">MTVDEKQPVADNGESSPAPSQYASVNERKLMAKIDWHVVPCLCVMYLLAFLDRVNVSNAAILGLKSDLNIESGTKYNTALTIFFVPYIIFEIPSNVLMKKLKPHTWLSLCMFGFGLVMVCQGLVQNWGGLMTTRWFLGMFETGLFPGCFYLLGMWYKRSEAQKRFSFFFSSTTLAGAFGGLLAYGLGQMDGLRGYSGWRWVFIIEGVLTCVVAIGCFFVVPDFPEDAKWLTEEERAFLRDKLAKDVGKSAADASMTWRDIAAVFKDYKIFIGGLMYFGQVVTAYGYAYFAPTIIQTYGYSSVKTQLYSIPPWAASFGFSMLIAYLSDKFRHRFLFTIIPMLVAMAGFGILLNIHDTAQYHVQYGALFLVTSGCYSAMPVLVCWFAMNLGGHRRRSIGTAWQIGFGNIGGIISTYSFLSKDAPFYRPGYSIGVSFLAFSAAMSILYFLAVWHDNKKRDRAIAEGRIDPSTITEEEEELLGDMSPTYRYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R772</accession>
    <name>A0A8G1R772_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_364700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518696.1">
        <property type="nucleotide sequence ID" value="XM_025655709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R772"/>
    <dbReference type="GeneID" id="37159111"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000490">
        <property type="entry name" value="CRM1p Major karyopherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH60774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1072" mass="123287" checksum="8B5139EBBE670970" modified="2022-01-19" version="1">MSVSIQELDNTVRAFYEGKGDLQKQAQQTLTEFKQNPDAWLIVGNILQESTYPQTKYLALQVLDDVIMTRWKVLPREQCLGIRNFIVNFIIENSKSEDKLRSERAFLNKLNLVLVSILKQEWPHNWPTFINEIISSCHTSLSICENNMAILRLLSEEVFDFSQDQMTSVKARNLKTSMTQEFSSIFQLCSEVLNTANQPSLVKATLETLLRFLNWIPLGYIFETPIINTLLTRFLDVPEFRNVTLKCLTEIGGLQIGNPYNYDERLVHMFTETLTAVSRIIPLSMDLKQTYAKSNSRDQEFVLNLALFLSSFFSAHLNLIEKLPNRDYLTHAHFYLIRISQIDDREVFKICLEYWTRLVQELYEEMQQLPITDINPLVSMGVSGLSNGGAPHPSTLANYPLRKHKYEEVLSSLRTVMIEKMVRPEEVLIVENDEGEIVREFVKESDTIQLYKTIRECLVYLTHLDVVDTENIMIEKLAKQVDGSEWSWANCNTLCWAIGSISGAMNEETEKRFLVNVIKDLLGLTEMKRGKDNKAVVASNIMYIVGQYPRFLKAHWKFLKTVVNKLFEFMHETHEGVQDMACDTFIKIANKCRRHFVALQPGENEPFIEEIVRNMRKITCDLSPQQVHTFYEACGYMISAQGQKGLQDRLIENLMSLPNSAWDAIIVQANQNPAILQDGETIKIIGNIMKTNVAACSSVGTYFYSQLGRIYHDMLNMFRASSQLISDAVAHDGNIATKTPKVRGLRTIKKEILKLIDTYVQKADDLEMVNANMVPPLLEAVLVDYNRNVPDAREAEVLNVMTTIIHKLHNLMEDKVPLIMESVFECTLGMINKDFHDYPEHRVQFFKLIQAINLYCFPALLKLDATQFKFVIDSCMWASKHDNREVENTGLTMCLELMNNMADTDAQTSNIFFQQFYIPILQDVFFVLTDSDHKAGFKSQAMLLSRMFYFIESGKVQNPIYSPEQAPLGTSNKDFLQEYVANLLQNAFKNLQEIQIKQFVVGLFAFNDDFNKFKTHLRDFLISLKEFSGDNADLYAEEREQALRDAKAAERDRAMRVGGLLKPSEMDQEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7J8</accession>
    <name>A0A8G1R7J8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_446178</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518940.1">
        <property type="nucleotide sequence ID" value="XM_025659446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7J8"/>
    <dbReference type="GeneID" id="37162848"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH61018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="508" mass="57841" checksum="A270A4062CC6D29B" modified="2022-01-19" version="1">MFTTNTILYLTKLESTTSIWAPVLAAIIFWLLSTPSLKTPLPVINQRQRFEIGGLGSLKRFFKDAHGLIRTGFSQGSAFYLYSEFGPKIVLAPKHADDFRTHPAFSLSNAIAEEFHAHIRGFDPFKQDPALVKDVLRTKLTPSLDKLARPLSEDTRRALGEMFTDDPEWHDLQLKPIVASLISRLSSRVFLGEKLSRNPNWHRVTADYAVHTFMSALFLRMFPRCTRPYVAYVLPFCRKIRNEIKEAEEIITPVVEERRSAKQEAIRQGQEPEHYEDAMQWMEECAKGRPYDPTLAQIALSLAAIHTTSDLLTQTLFYLAEREDVIKALRNEVITVLQNDGWTKSTFNDLKLMDSVLKESQRLKPHSIAGMRRFAQEDVTLSDGTVLPKGTISVLTSESMWDATIYPEPETFDAYRFLKMRETPGLETAAQAVSISPHHLAFGLGKHACPGRFFAIALNKIILCHVLLEYDFKVADGWNPTVRKYGFVWQADPVAKVSVRRRKEEIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8G8</accession>
    <name>A0A8G1R8G8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_518066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518463.1">
        <property type="nucleotide sequence ID" value="XM_025664949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8G8"/>
    <dbReference type="GeneID" id="37168351"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034808307" evidence="6">
        <location>
            <begin position="23"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="121"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH60541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="580" mass="62562" checksum="6AB883AD95249C79" modified="2022-01-19" version="1">MVRSLHWLATSAGLALLPFSQAIPALVQGSSTCRYLPGDSEWPSAADWHQLNTTVGGRLSATVPLGAPCHEPHYDAAQCAYLAAEWIYPELHANSSSSFSNPYFQNQSCDPFTSKTSPCLLGNYPDYTIDVRDAADAAAGVTFAREHNIRLVIKNTGHDLLGRSSGKGSLGLWTHHMKNISILDYHHPRYTGKAMKMGAGVQGFDAYAAAHKAGLRVVGGTCSTVGLAGGYTQGGGHSMLSTLYGLSADQVLEWEVVLADGRHLVATPTDYPDLYWALSGGGGGTYAVVLSMTVKAHADGIVTGASVTVTQTNSSDAFWEAVTAFHTAMPAWIAKGAATAYVIMDGSLYLMPATFPGYNASEVNGFMQPFVAQLQRLAVNYTISVNSFDNYYTFFDTFFGPLPDGSYTNAQVQGGRLIPREVLMSADSNRALTAALREISSNRAFRIIGVGTDVSRGGDVPNAVFPGWRKAITWIELTADWDFTQSYATNVANETLITNRFDPLLTQVTGLANNSGAYLNEGDFRQKDFQTQFFGGNYASLKQVKRRYDPEGVFYGTALVGSDDWEVASDGRLCRSSESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R910</accession>
    <name>A0A8G1R910_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_388827</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519720.1">
        <property type="nucleotide sequence ID" value="XM_025656727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R910"/>
    <dbReference type="GeneID" id="37160129"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH61798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="236" mass="26127" checksum="25A468F1D9F62A28" modified="2022-01-19" version="1">MDSSPAPFKAQHHMGDNKIHVLLAASGSVATIKLPNIAEALGRHSNISIRIIVTKSAAEFLKGQSHEQPLLEKLLELPGVDAIYRDEDEWRHSWTRGESILHIELRKWAHILLIAPLSANTMAKMTMGISDNLLLSVLRAWDTTGTVDANFKEKKPIVFVAPAMNTAMWFHPITAKQLAILNDEWGVNSRNEGWVSVLNPVDKSLACGDTGTGGMMEWKTIVDKVEQYLGIGKDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9A1</accession>
    <name>A0A8G1R9A1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phospholipase, patatin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_197193</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519409.1">
        <property type="nucleotide sequence ID" value="XM_025654486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9A1"/>
    <dbReference type="GeneID" id="37157888"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="8"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH61487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="328" mass="36524" checksum="AD00EE7B5D1259E9" modified="2022-01-19" version="1">MVRNISLLSLDGGGVRGLSSLYILKHIMESIDPENTPKPCEYFDLIGGSGSGGLIAIMLGRLEMDIDQCINAYKRLSNHVFARKRLLPVGGNLRRQSKYDGRRIETAMKAILHELGYEDDILLREPASPCKVYVCVTDDGSKRNLAPLTSYPSKYCSNELYKTAKVWQAGRACFSTEQLFDPVPIGPSGRRFYNSNTDANNPVREVWIEARGIWPSGSLDTQIRCMVSIGTGVPSIKRSSKAMFGLLKSSRTDSIDTEVDMNKFLREHTELDDENRLFRFDVPNGLADISLDGIDEIDTIVDATEEYLAKEPVYKQIQKCGRALSAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9D4</accession>
    <name>A0A8G1R9D4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDE1</name>
        <name evidence="10" type="ORF">BO85DRAFT_445364</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9D4"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH61959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="242" mass="27445" checksum="EF3B222BE54D1D3D" modified="2022-01-19" version="1">MAQEIQKENNDHLVQSSDPEHPANLIPDLCRRFYNWGWVTGTGGGTSIRRDNHIFIAPSGVQKEMMKSDNIFVLEFPTPKYPPSDRKYIRKPLDLKPSACTPLFLAAFERGAGCCIHTHSQWAVLVTLLVEREKGPNACFEISNIEQIKGIPRGKGKGMMGFYDTLRIPIIDNTAFEEDLTGSLEKAMEEYPDTYAVLVRRHGIYVWGDDVVKAKTQCESLDYLFQLAVEMHKLGLPWVKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAH9</accession>
    <name>A0A8G1RAH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DUF907 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_456175</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520069.1">
        <property type="nucleotide sequence ID" value="XM_025661429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAH9"/>
    <dbReference type="GeneID" id="37164831"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF2">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034921820" evidence="9">
        <location>
            <begin position="22"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="23"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="636"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH62147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="705" mass="76694" checksum="5D084C8B4D2AAF7B" modified="2022-01-19" version="1">MRWSTCLTSALLASTAPLVAATRLIESNALNICQDSNNFTATYFSVRFTPENRSLVLSFDGVAAISGKVTADLSVDVYGYQLTGETLDPCKMNIEGLCPMSAGAINVQNTPIQIPEDVVRRIPGIAYTVPDLDATVRVYINSTDTGTSITCLEATLSNGKTVYQKGVGWTTAVISGVGLIASAVAAGLGNSNTAAHVAANVLAFFSFMQSQAMFGMISVHMPPIVEAWTQNMQWSMGIIHVKFLDTICTWYQRATGGTPSTVLSELSTTSVEVLKKRSLDSVTNVFKRQYAQSETATTGTTEVRGIDRVGFRAGIEGTNIFLNGFIFFVFFVAVVMIIVGLLKVGSRFLAKKGKTKTDKFGDFHVSKGILYRLIFIGFPQMCVLCLWEFTQHDSAAEVVLAVVMLVSMICTLGWAAFRVIILARRSVAMHRNPAYILYSDEACLNKLGFLYVHYRATAYYFLVFALLYIFIKAMFISLSQPAPVVQTVAMVIIETSALIGISIVRPWMDKKTNGYNIAIASINFVNSILLLFFSNVFDQPGIVTGVMGVVFFVYNAAFALILLFLVLYSSVYAIFSKDPDLRYRPMRDDRGSFAKSGSQLITELDALGTTARGEGTPEMWNKGSLLDDTGSVASEGLHRSHQDLARDTAPGREMSETPVSQANLFPISRGSSPVHRAASLNAAGVRRSVLSDSDNASATHPHANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAN8</accession>
    <name>A0A8G1RAN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_456821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519196.1">
        <property type="nucleotide sequence ID" value="XM_025661474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAN8"/>
    <dbReference type="GeneID" id="37164876"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059009">
        <property type="entry name" value="Znf_C2H2_17_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26177">
        <property type="entry name" value="zf_C2H2_17_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="262" mass="29445" checksum="855E3CC72DCCF366" modified="2022-01-19" version="1">MGDGSDYPSPRSEGPGGPTSVLVTVPDSLSPAPKMNDQLSPNFMEGTRPRLSVRRARDPPKNTAGQIYCDHPECQHSPPTFRRPCEWNKHMDKHDRPYKCMEPGCDKIQGFTYSGGLLRHQREVHKKNINAKKPLMCPYADCNRSTGNGFTRQENLKEHLRRRHMHTENGHASELPIAPSPDLDGTTSLATASAALKRKRESLGDDPATLELPEEEENGVDLRNELKRLRREVQEKDRRLEELERIVAGLQQAIPQTATSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAV8</accession>
    <name>A0A8G1RAV8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_434348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519599.1">
        <property type="nucleotide sequence ID" value="XM_025658462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAV8"/>
    <dbReference type="GeneID" id="37161864"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH61677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="355" mass="39999" checksum="75DDAEE8F486ED3F" modified="2022-01-19" version="1">MTDGIQSRIPPNLPETPDARMWKATLLIVAAISLSTVLGASVYDAYPQLKQFKAQDAFSYEWNTTEEWRCPLFKERQLRTRLKVLKAGKCIHKAVTNTLNGPGVSCCGIQGKCDFRRDISYSRTRSATDGWKAGMQAKFGGSGVTGEWTFTAEYSGSITESAGKTDGTSMGWTQLEPGWIYVPKISFLEVHCTAIVYEDSPTIFGPKTDGPLWIEDHHTDGTIDSDYELMWLTIPEDRMCQIPEGILWWGKHDKTMQIPGNVLLRPKEEQGSGLKMHDRYRDFWRRSELSFPVLDSSGNILSVYGLEKLTCDKAAGYVEDEDGYLQHSAVLFINGTKRREIIEEEIGKHALHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB80</accession>
    <name>A0A8G1RB80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_107650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519466.1">
        <property type="nucleotide sequence ID" value="XM_025653835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB80"/>
    <dbReference type="GeneID" id="37157237"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH61544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="141" mass="15464" checksum="DA3189D7892BB5AA" modified="2022-01-19" version="1">MPRRFHGIKPTTYIFPSRTCQTSLRPALQMDIAVSPLSSANNCLTPRLLNLTEERIVCELNRMKRDPKSPDSKHPRVCLAMTAEKGHHRFGHCVGRGVNGRCDYPVVKETIASADTTNDVVGSWKGIHAPSGVIACPVQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBI0</accession>
    <name>A0A8G1RBI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ARCA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_18396</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521036.1">
        <property type="nucleotide sequence ID" value="XM_025654368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBI0"/>
    <dbReference type="GeneID" id="37157770"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH63114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="58840" checksum="9E0A9D136D1AC78E" modified="2022-01-19" version="1">MSSQPRKWKLFSGDSSLPQSMDVVQSQSPYQESTVQCDTPTSGETDDHVLTRDNCSHRGTHFEIQSPPPYDPSRNGFHPVISGDTANVNGRSYIAHEWDTLNNPSRKSSINGMQPSSTAIETQSPFPTPKPAQTTVQEACLLRHFIEEISPWFDHCDDRRHFQLVVPRRAQHCSIIRNALFAVSARHLSRLPQYATPNGICYRGQLLLNLQKCTAVEYTLKCIPELLKFPEITDPTEQENIMVATVILRQYEEMEEDFEDHDMSTQDRVNFLAITQRIIDAMISHRLEQSLATAAYWIVIRQEVYYALTRQRAPKMRFSPEDWRKASVANTLVMLASEVTKWRWGDGTREEWNRLMLRHRKLQHDYRHDLAPLFEKKADRSRGELFPTIWYSSDEQVTAVQHLEIANMILTAQNPYLSNSTRAAHRKAEAEVRSIVLRICGIAVHHAHCHPALVTAVIAITLYGEYFTEWEEREALVGIIDRTRDLHSWPMQKCYARLRQGWEEMDHCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBP5</accession>
    <name>A0A8G1RBP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_360339</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520820.1">
        <property type="nucleotide sequence ID" value="XM_025655546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBP5"/>
    <dbReference type="GeneID" id="37158948"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="11"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH62898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="506" mass="55816" checksum="3E90C8BB519DF359" modified="2022-01-19" version="1">MQGQALRYAQIFLVACPSFILFGYNQSGVGGLDDFPSWVRVFPEIDTVNTTGAQESHNATVQGAVVASYTIGALFGSLICTMIGDMLGRRRSIFSGALIALIGQILECTAYSLAQFVVGRVILGFGVGMLSATVPVWQSECAPAAQRGRNVVLTGMFIAFGFALTQWVNFGFYHMENSPASWRASLAIPALFSFIIMGSIFFLPESPRWLVMKNKSDVAQFTLASLRGQEVDSLEVVAELRAYELSLEESSNNSLKLRDIFTMGEEKLLYRFILCVTLQFFQQMTGGTLISVYIPLIFQTDLGLGTSLSKILAACALTWKFLCCFVGFAIIDRMGRRTAFMVSGGGMGMCMLALAVSNSFSNNHTASIISALFIFIYNFFLPIGFLGANFLYPAEVAPARLRVAMQAISIANQWLWMFVVAMITPVAIDNIGYRYYIVYAIIGGIIPPVIYLFYPETKGRSLEEVDEIFRDAPTIFSAVSMSKHKPMGDRAMERVMEEKATVEEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBX4</accession>
    <name>A0A8G1RBX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RhoGAP and Fes/CIP4 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_133371</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520293.1">
        <property type="nucleotide sequence ID" value="XM_025654010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBX4"/>
    <dbReference type="GeneID" id="37157412"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04399">
        <property type="entry name" value="RhoGAP_fRGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000044">
        <property type="entry name" value="Rho-gtpase-activating protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000050">
        <property type="entry name" value="RhoGAP and Fes/CIP4 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000073">
        <property type="entry name" value="RhoGAP and Fes/CIP4 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF17">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN RGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="6">
        <location>
            <begin position="2"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="227"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="464"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="672"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="756"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="779"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="805"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="825"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="842"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="855"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH62371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="880" mass="98150" checksum="7CE6211E4A446426" modified="2022-01-19" version="1">MPGFADSFWTPDYATGLGVLYGKLQQGAVENKQIITIASMRADAEEQYGLKLGEIAPTVDRVTPTGFGKDDGASVRKAYEGVRTEMVEASKNHQKIASNIRELVVSPFRRWCDQHEARIQNSHDDLQARIKEHSKQVDLVKKLRSHYFNKCRVVEDLEEENKLAFQAPETSPKIKPTPKIVLPEEQEEEEPVEIGDRIYPPEDLKRLLTHMLENIKIGEVKVPIIGTYQNTSTGADIVEYTQKHLNGTSITYSERIGQDLVDNGFLRLVGNMGSTFANSSKMRYQWRPKVFQITGVPEKKKPLMRVTSVATSEDGSESPLSSVSEMLAGWNPLNNPYPNETPAEKLRREAREADERYKAAVRKLDMIRCKLEEEVVENLRFMEQCELDRLKAIKAVILDFSGAISNVIPNLQSTVDHMMLYQETIQPLGDLRYLLENYRTGGFVPRVQAYENYYGSVEDQNFGVDLEARARADRKRVPIVVTTLLTYLDNRYPDLEGDEARRAIWLYDVPLAATHHLRSALNNSKADYNEILEKYEIPIIASVLKLYLLELPDSLVSSQVYEIVKTIYSTTAHETTEEGRIKVLQSTLGQLRLNNIATLDAIMTHFTRLIDLTSADESYVSALAQALSPCILRPRTESSLTMNERHSYRLIRDLFAHKDAIFGELKRQSSALGISGSTNRPRAISTDESNRRAAMEARNRAILDRSRANSPAPPQKHRRDRSSGASETRRFPINVTSPTERRTVARSSLDVPIKSESPTAAEQMTSVNINGPEPVTNGALSESPVSAAASASPSSGSASPPPAPESDASVTPTTTPTQDTEKRSSTISRSSVSYTRKPGLGNRSSFPTVASTEGTDSKRSSLAETEPKGVTLEDKPMDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC86</accession>
    <name>A0A8G1RC86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_483372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521456.1">
        <property type="nucleotide sequence ID" value="XM_025663155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC86"/>
    <dbReference type="GeneID" id="37166557"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="112" mass="12662" checksum="E391F7F1AF663CA3" modified="2022-01-19" version="1">MTARDVVLLLVSVGRFGCFDNRAASRQECGVFRRGLALFESLTSLLTLSASLREYDIFIRASIEGLVQALFEGLVFLCSFVPDVCRYSFEDAVYLGRYRASLRDVMVCQTLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCD9</accession>
    <name>A0A8G1RCD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Cytochrome b5 reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_362354</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520394.1">
        <property type="nucleotide sequence ID" value="XM_025655626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCD9"/>
    <dbReference type="GeneID" id="37159028"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF178">
        <property type="entry name" value="CYTOCHROME-B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="7"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="222"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH62472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="466" mass="51010" checksum="E467FA02D831CF9B" modified="2022-01-19" version="1">MGADSQLAEYTLADVAKHNRKDDIWIAIHGQVFDITEYLQDHPGGVDVLLETAGTDATADFEDVGHSEDSREILQDYLIGTLKDAKKFVPPKAVRVISQKPEKTENPATNGSSLLAVTGALGAVTTLLYVLNRKSPGVFDMRKVLGSAMPQEFSGIRLPGGGFANGFLAATLFSCAIGSVVARQAAKMMKIEHGFMRYPPHIKARKVARADPHMAKGFLDSKEYQRLPLIQKDLLSPNVYRFVFALPDTKGVIGLPIGQHVAIRAIIDGNTVSRSYTPVSNNLDLGRLELVVKCYPDGLLSGKYLANLNVGDEVEFRGPKGAMRYSRGLCAKIGMVAGGTGITPMYQLIRAICEDERDTTEISLIYANRSEGDILLREELEEFARKYPKNFKLWYMLDAAPEGWTYGSGYVNETVLRERLPIPSAETKVMLCGPPGMVNACKKTLGAIGFQTSGTISKMSDQIFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCJ0</accession>
    <name>A0A8G1RCJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_5149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520593.1">
        <property type="nucleotide sequence ID" value="XM_025664768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCJ0"/>
    <dbReference type="GeneID" id="37168170"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="119" mass="12376" checksum="5BFC3596B65A52D6" modified="2022-01-19" version="1">MATAMHDDGYHSMPPTGGEGCRPPGDHLETGRAADPNSSVEDYSRVMLEYTQRRMADFADLDDGKGSSRSSRSSQTSGNSGNSTSGMLARQAAGTTGAAHDSSESARRASGVNSADLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCW5</accession>
    <name>A0A8G1RCW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DUF1212 domain membrane protein Prm10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_482628</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520664.1">
        <property type="nucleotide sequence ID" value="XM_025663113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCW5"/>
    <dbReference type="GeneID" id="37166515"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="607"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="643"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="686"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="711"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="734"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="766"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="834"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="419"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="692"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH62742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="869" mass="93477" checksum="1E084BE89129FFFC" modified="2022-01-19" version="1">MAGGYFDLPISSTSRRSSLTDVSGGASRSSPGPRVLTPLPTPNESSQERLPDPSGAQGRLRNAAIPRSANRVKFTVSEAGLGTSPSGSTSAARFVGRGSSLPQRPLPTASIPSAVKASPDPQSVPLIDISPSPKVGVTGLTVHSAPSFTGATGDDDEVSNEKGRAIHSAQERAQRLASVLHQSSKTPKSSPWPSRPSSIASSPSEAALPFEDGDEIPMISLSEKQFGDFSDDDDLGPLNGRQSIRTSQAHQLVRQMTRSDFDFLSRLQAPSAGLESGQVTPHEERDPDAYVERPTHYRGGILSSLLKLYDQPGSHYSRGRNASLRRSSTGEFSSRGLSPDPTWKSQRPRKWYEKSPNQSSTSLAGSTAKNSTSSPIAMLKRSRSSGAIPNVPKRMGKPQLEDEIRITVQIAELLSRQGYLIRLCRALMKYGAPTHRMEEYMKMTARVLEVDGQFLYIPGCMIISFDDASTHTTEVRLVRSPQGVDLGRLCDVHLIYKEVIHGVIGVEEAIQRLDEILKQKNKYPVPLVILIYGCASACVGPFAFNARPIDMPIAFLLGCLLGTLQLVLSPRSNLYANVFEISAAVLTSFLARAFGSIRYGDGRLFCFSALAQSSIALILPGYMVLCASLELQSRSIVAGSVRMVYAIIYSLFLGFGITIGTAVYGLLDGDASSDYTCPPSPITNEYLQHFPFAILFTFCLAIINQAKWKQIPMMLIISFAGYVTNYFGTKRFYSSTQISGALGAFVIGVMGNLYSRLRHGFAAAAMLPAIFVLVPSGLAASGSLISGIAAAEQITTSTSPFAVVSNGTQGFVDAAKNLSSPNFDREFHGVVLDIGYGMIQVAVGFTVGLFLAALVVYPLGKKRSGLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDK2</accession>
    <name>A0A8G1RDK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_494767</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="11">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521024.1">
        <property type="nucleotide sequence ID" value="XM_025663874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDK2"/>
    <dbReference type="GeneID" id="37167276"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000001">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="VOC" evidence="12">
        <location>
            <begin position="29"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="12">
        <location>
            <begin position="198"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH63102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="399" mass="44711" checksum="1D85E7F065A5FA39" modified="2022-01-19" version="1">MRYNGVTGDSSKIPANLAVIKNINPNYTGFDYISWYLGNARQAATYFVAHFGFRVIAYSGPETGSHLTTSYVVANGNARFMLTAPVTGPQNIPSDKDVSEKDRSLMTEIQAHLVKHGDGVKDIAFQVDDVRGVWEHAPTILTDDKDGEVLCATIKTYGDTAHTLINRSNYRGVFLPGFRSVNDMNALNELLPKVDLIEIDHCVGNQPWNGLDGIVKYYEDALNFHRYWSVDDKDMCSDYSAMRSVVVASPNNVIKMPMNEPATGLKKSQIEEFVDYYGGAGCQHIAFRTNNIIEAVENLASRGVSFLSMPSSYYVNMRERLALKNVKLAEDINLLEKYNILIDFDEGGYLLQIFTKHVGDRPTVFMEIIQRENFDGFGAGNFKSLFEAFEREQALRGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDS6</accession>
    <name>A0A8G1RDS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cleft lip and palate transmembrane 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_361290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521298.1">
        <property type="nucleotide sequence ID" value="XM_025655587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDS6"/>
    <dbReference type="GeneID" id="37158989"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="561"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH63376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="601" mass="68209" checksum="5B7E3966A338A7CA" modified="2022-01-19" version="1">MSQFFGSKQNAGSGAKPSDVPSFNTRPPRSEVSNYSPVPDLVTPIWPSDSALDLNIYVSPSILVPGFKSFPSDSLVLEENNFTIGNYSDTREIDTTIKIPKEVQRNGTLWAHFFVGLTGHQLDPTAKDYSTDSAVHFFRPLNQYLPKKKVKKLKNLLASSEETQEEEDDGTPDVSIASYYHPNFTVSVVPDSGAQKYRQVHPAVRQHMQLEATGARDATGQNGWYYPIVFLNTFWQLRSHMMELNSTVETVPMRITLNNLQNWKFSMMASVDENAKANAKQAAFGGQTPGGGDGTEFEMVKEVLLDTNIYLLCTTGVVTILHMVFETLAFKNDISHWRKKKDVVGTSVRTILANVFMQAVIFLYLMDNSENTSWMILASQGFGILLEAWKITKTVDVRLRPPPAGSFFSFLPYVIVFEDKHKLSETEQKTKEYDEIAFRWLYIIAVPLLAAYAVYSLIYNTHKSWYSYVIETLVGSVYAYGFLMMVPSLYINYRLKSVAHMPGKALTYKFLNTFIDDLFAFTVKMPWLHRLATFRDDVIFFIWLYQGWKYKVDYKRVNEFGQGGDSDEEEEEPTSAEEPKAKETATASGKASSKQPARKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1REA3</accession>
    <name>A0A8G1REA3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCD97-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_9159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520757.1">
        <property type="nucleotide sequence ID" value="XM_025665783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1REA3"/>
    <dbReference type="GeneID" id="37169185"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040233">
        <property type="entry name" value="CCD97-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018613">
        <property type="entry name" value="Ccdc97-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09747">
        <property type="entry name" value="CCD97-like_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="38"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="131"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="209" mass="24046" checksum="C5D51FDBD8C89FA5" modified="2022-01-19" version="1">MPLFPMGTGVAPEADSSQMESDPVKRTQSPSAATKIKNRRKRYLDMHPEYFSADLELADPLLYDRLIRRFQTPAEREAEGRAKGFSGVLQADLCRSEAKFEALSHPDPHAMFSYTRGPNGEILAEDRDEIPPNKEEGEKAWRWEMTLRFLRGEDGDFDYTSVDDNDEYDDWNVEQEKYFDDEEPEWLVEGVDDGEVKSHLQGETGIQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1REN0</accession>
    <name>A0A8G1REN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="8">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_386894</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FAN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="8"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520937.1">
        <property type="nucleotide sequence ID" value="XM_025656646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1REN0"/>
    <dbReference type="GeneID" id="37160048"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22326">
        <property type="entry name" value="FAN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000009">
        <property type="entry name" value="Fanconi-associated nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049132">
        <property type="entry name" value="FAN1-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049126">
        <property type="entry name" value="FAN1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049125">
        <property type="entry name" value="FAN1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21315">
        <property type="entry name" value="FAN1_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21170">
        <property type="entry name" value="FAN1_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="10">
        <location>
            <begin position="705"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="585"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH63015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="846" mass="97321" checksum="8F06FA4133CCE1FE" modified="2022-01-19" version="1">MSLLHYWDTFRPSAKRMKTTKEETDTGDEKDTPDSSDSPLIKSSETPLPERLDYNPIPVEAGFGAAGDDSEVPPNSQTELESSLPAIQADNRAIEEYEASRAADDEKEPDLRQRLRDGTWRKGRSSIYVDAFNLALETVLDEEAHLFDKAEMEVFRQWRELDYESQYLYVRLFLRKTSAWHRVNRLGYYSDIADMPRVVAELRRARNLPSTSEDGNSTDGTVPVDTSSVLGQDGEFKFAEEMDQITTLEEASSLLLLDELKTLARDAKVTGKSKKELITALQRSSQKQTGLDWNSKSNGNNRDDHFIQKILDYTGDCIRLASGPRALFERVHLVFYRSTEWTEKSLTTIILAKISRRNFPEYVVCRTNSIFPSREILLEFESALRTQYQIDNLLEFNGTPTVELLTQVKDLAYKVYPRWKTLLHQEQQKEDTIYDYNEGAYLRRFSPAWVYTRIIHKGLHPLGRFKEHEEEHRLLSELLTQRLFHAARRGAWYQRKALLEEHYLWALKPSEGRSEEVQRKHWRRIALQTCETGLQDPDCHLIYHYDLQKRITKLERALKVVKREQHDFGHVRLAKPAERTIEGIQIERDEPTQTQPSTPADTATTPTITTSSKRGRPTIWLDPRDGGECRVESMCLSWYRDRGWKGYHSEGGIIRTLFTYLFYDILYTYVPNVFQTPFQTSPLDLHTDAFYPTRLSQINHRLVEITNGESERLIRAVYAEQSPRQTCAIGLDWSFELDDLVQIVRCFPGEALAAVCRVVAQEYQARGGGVPDLLVWRVYDGEEGKSDGDGDGNGKGKEGYGEVMFVEVKSANDRLSDSQRLWIHVLASAGVRVEVCNVVAKEVIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RHZ8</accession>
    <name>A0A8G1RHZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_495765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521607.1">
        <property type="nucleotide sequence ID" value="XM_025663945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RHZ8"/>
    <dbReference type="GeneID" id="37167347"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="310" mass="34520" checksum="FB6485CFDC00CD4F" modified="2022-01-19" version="1">MSPTSIKTRFLILSDTHGAELPDACFEHSADVVIHCGDLTNSSYITEFQTSIKQLQRLKAPLKLVIAGNHDFTLDTPTFEQKIREAGLENDSSVKKVYGDYEEVRTLFKHEQDNGIIFLDEGTHSITLPNGALLNIYASSYTPSLGDWGFQYPPERGHDFQIEEDVDIVITHGPPRGIMDYTDNRRAGCPDLFKAIARSRPQMHCFGHIHEGWGAMIAQWRDRTVVGNEPSHFTAIDYGRSSVVTKLSRLDPETSPAVVETSHCTDDAIPLKPDHQTLFINAAFEASNMAGDGPAMHPVWQVDLELPCAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHQ8</accession>
    <name>A0A8G1VHQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Autophagy protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_453100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511523.1">
        <property type="nucleotide sequence ID" value="XM_025660985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHQ8"/>
    <dbReference type="GeneID" id="37164387"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="4">
        <location>
            <begin position="7"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="83"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="206" mass="23204" checksum="B46EBCF9B5F27D78" modified="2022-01-19" version="1">MAHWKEEYSAALAARDRREKASIAIYDAYTQLADRTVQGAAASNPPSSDPVEAQHVPSDTSASRSSKALSGAGAQDLSLQETLLATRADLAEAQRSRSELQDQLTRMTADLEKLRKRSTQDSRRIRLFENETAHLQLRLKDRDEELRGKAKLLEDFQDELASLNLQLNMAEERSSRLQKENQDLVDRWMARMGKEAEALNEASKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHU9</accession>
    <name>A0A8G1VHU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_463795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510519.1">
        <property type="nucleotide sequence ID" value="XM_025661943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHU9"/>
    <dbReference type="GeneID" id="37165345"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="19131" checksum="C4C75329AFDAFA3B" modified="2022-01-19" version="1">MGKYDEANEIEFICVIKGGKDVKVKQEDDMTLRQLQAYIQTTQKLIGELTLYYNNKKLTNLYAPIGEVLKPGDTLVIHNNTKAIVATGGFGMGGEAKSNSSNQAVAHGGHATGGMFYPSGNPKAGSGTGGDAWGDYGAGGDGFGGNANNVHGSVKAGLAVSGNFHKHEEHRSMKERLFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VI88</accession>
    <name>A0A8G1VI88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoflavone reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_502769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512033.1">
        <property type="nucleotide sequence ID" value="XM_025664214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VI88"/>
    <dbReference type="GeneID" id="37167616"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH54111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="300" mass="32283" checksum="EF361CD37C96ECB5" modified="2022-01-19" version="1">MASPLKNVVIVGAGGNLGSHVLKAFLSSKAFNITALTRESSTSTFPDGLQVIKSDYSHYSLVSAFKGQDAVISIVGNAGLSFQQKLIDAAVDAGVKRFIPSEFGNNTADDRVRALAPLLDGKKANVDYLKERQDRLTWTALITGPFFDAGVKNGFLGFNLQSHEATIYDDGTNPASVTTLAQIGRALVAVLQNPEVTQNQYVYVESFTITQKQILGALEKATGKDWKVTDVALKPVIEESTQQLKGGDFTAVRVLLLAAGLARFPDGPYGDWSRVPGGSWNERLGLEKENFDEVVGSLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJG4</accession>
    <name>A0A8G1VJG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase</fullName>
            <ecNumber evidence="9">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_480643</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="9"/>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512184.1">
        <property type="nucleotide sequence ID" value="XM_025663021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJG4"/>
    <dbReference type="GeneID" id="37166423"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.920.10:FF:000002">
        <property type="entry name" value="DNA primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="438"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH54262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="514" mass="57762" checksum="EFA48D8D58D51CDF" modified="2022-01-19" version="1">MPHSVSSQDSSADRKDDELMPDAPPTETASANQEDNAAAGVKLEDLFNDDDDDEYPASSAPETQNGASSAPEPAAAPGPQVDTDTMLAFYQRLFPFRYLFQWLNHGIVPSPDFGNREFALTLQNDAYLRYQSYATADLFRKDILKMNPSRFEIGPVYNTNPRDRKTLRGGQMKPIAKELVFDIDLTDYDDIRSCCEKANICSKCWAFVTMAMKVVDTALREDFGFEHILWVYSGRRGAHAWVCDPRARSLPDDRRRAIAGYLDVIRGGNSSGKRVNLKRPLHPHMSRSLEILKPYFAQTTLVDQETFSSSEQTQRILSLLPDKGLNESLRKRWESSPDRSSANKWADIDALAKTGKSSTLNPTTLRDAKQDIVLEYTYPRLDSEVSKKMIHLLKSPFVIHPGTGRVCVPIDARKAEQFDPLSVPTVTELLAEIDAWDAEHPSNNAGPEVAEGEGSVPESDARGSRRLQDYEKTSLKPYVDYFRSFIAGLLKEERTGKRERADDATEVKTESMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJP7</accession>
    <name>A0A8G1VJP7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenosine 5'-monophosphoramidase HNT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidine triad nucleotide-binding protein HNT1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_521699</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine 5'-phosphoramidate + H2O = NH4(+) + AMP</text>
            <dbReference type="Rhea" id="RHEA:67916"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57890"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67917"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HINT family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513786.1">
        <property type="nucleotide sequence ID" value="XM_025665212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJP7"/>
    <dbReference type="GeneID" id="37168614"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000013">
        <property type="entry name" value="Hit family protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="12">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="10 11">
        <location>
            <begin position="95"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="9">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH55864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="135" mass="15078" checksum="F20A75F5A7AC3EDF" modified="2022-01-19" version="1">MSSAACIFCKIIKGDIPSFKLFESDKVFAFLDIQPLSRGHALVIPKYHGAKLTDIPDEDLQEILPVAKKIAKVTGAEDFNILQNNGRIAHQVVDHVHFHMIPKPNEKEGLGVGWPAQETDMDKLKALFEELKAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKF3</accession>
    <name>A0A8G1VKF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Low temperature requirement A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_51290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514403.1">
        <property type="nucleotide sequence ID" value="XM_025664677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKF3"/>
    <dbReference type="GeneID" id="37168079"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101:SF1">
        <property type="entry name" value="LOW TEMPERATURE REQUIREMENT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="64579" checksum="FC6D08C0C50724F8" modified="2022-01-19" version="1">MIPIPFKSWFDHPSSRDRRARAATQQRSVIAFIESPVDEKEGDLPHLRQQSEATPIELFFDLFFVANLSTFTATHEINNVEALWAYIGFLGIIWFTWLQVTLFDIRFARDSIFERICKALQLAAMVGFASAGSRFTTRVQPENVWAFQSLSLILGGSRLLLALQYTVNAVFLRRRMIPAARGVSIIAGMQFVSSLTYLLMYYAFRPREGVNPYIWTVWFVLFGVEMWVVMGTSSATPGIGLQDTHLDTRMGLLTLIIIGEGVISVTRLVNRTVGPGGWTKWSFVHILGVTTSVYFLWQAYFDLSPRRVLGKYSQQIWAQLHFPFHVVLILLLEGSQILALSLDITLKLRYLAETILWACEDPRPRPDYAIRILRATIADMEIDYSRGAVNEQVTISRILDDLPNHPLCPSRRTGQVPIARDMLSDLVGNVTAALFSTMRIMPSNHPDPGRLTSEQLLRGYMALLEFVYVYYFAVASLSMMFFGAFVLLARRHTLRRCMGISAAARVSLGMLLGSLMSFSRHFPLVYSFMTSPAILYAFTLTLFMVLLMDRLLDRYQSYGRRTQESEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKT0</accession>
    <name>A0A8G1VKT0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_469833</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513937.1">
        <property type="nucleotide sequence ID" value="XM_025662355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKT0"/>
    <dbReference type="GeneID" id="37165757"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="11"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="168" mass="18855" checksum="D0F5C5B36770CA52" modified="2022-01-19" version="1">MFSSTVARPLQLATRFMQWASAVIVMGITSYFIHKGPRGQHTIYWEVISTMSVVFFLPAFISPFMPNALSKFVLIIDVIFSYLWLTAFIFAAQDYNWHNCAFNSPPGLSCSKKKANEAFIFLTFIFTFFAMFLEVGALWAYRRESTPVREKNTGGAHGGPADAPLATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL62</accession>
    <name>A0A8G1VL62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_450420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514327.1">
        <property type="nucleotide sequence ID" value="XM_025660373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL62"/>
    <dbReference type="GeneID" id="37163775"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF177">
        <property type="entry name" value="PROTEIN YOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="323" mass="35344" checksum="3A2F0FE45689CBCA" modified="2022-01-19" version="1">MFGIIADLLSSIITILLPIFASYKALRTGDPSQLAPWLMYWVVLSAVLMAESWTIFILGWFPFYSWFRLFFFSYLVLPQTQGARSLYQEYVDPFLEHHEREIEEFIGRSHERAKALGLQYFYQALDYVRENILGLPAQHPASPPPPTGPAAYAQSLLSRFNIPTAAGGTAPATGNDWLSAIGSAVASVASGKSAEARGEELSASGTLLPREVASMSRADKAKYISSQRDMLEVLRSALAKEERDLHSAGAEVDDLAYGGAPLRKNRSENSFTHVEHEDTQERSSDAHGRTSSGNWASGWFAGGEQAGSSGVDHGNEGARSRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLJ0</accession>
    <name>A0A8G1VLJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_99073</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512680.1">
        <property type="nucleotide sequence ID" value="XM_025665832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLJ0"/>
    <dbReference type="GeneID" id="37169234"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07135">
        <property type="entry name" value="ALDH_F14-YMR110C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000025">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF11">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH54758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="514" mass="56649" checksum="E9C1455E47358033" modified="2022-01-19" version="1">MGAIEIPPLEYTPVDEVAERVSRCRKTFHEHTTRDVEYRLVQLRKLYWAIKDRVDEIHEALRLDLNRPLFEAVMAESTWLLNDIVFVCRNLPKWVKDEKAEDIDLTFKFTSPKIRKDPLGCVLVIGAFNYPFQLTLGPVIGAIAAGNTVVIKPSEKSSNCAVVIQQIIEAALDPSAYTIVQGAIPETQALLAERWDKIFFTGSANVGRIIAKAAAPNLTPIVLELGGINPAIISKNADPRLVARRLFWPKLMNAGQLCTSQNYLLVERPLVDAVVEEFKKVYKEFYPQGAKGSADFSHIIDDASFHRIKGMIDNTKGKIVMGGSMDEKERFIEPTVVVVDSPEDSMITQESFGPLIPILPVDSVEQAVQIANGVQSTPLGLYPFGSKAEVEKILSQTRSGGVAVNDAALHIPTLPFGGVGESGQGAYRGKASFDVFVHRRTITTSPSWIESFLAIRYPPYNGKEELFKKATTLIPDFDRDCKKVQLSWLRYFLTLGGGSAKSGAARATVVAAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLK2</accession>
    <name>A0A8G1VLK2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_450552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514449.1">
        <property type="nucleotide sequence ID" value="XM_025660397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLK2"/>
    <dbReference type="GeneID" id="37163799"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="71"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH56527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="259" mass="29193" checksum="49F5BC17D700F739" modified="2022-01-19" version="1">MLRNSRIASRLVRTGVLQARTPASPHTSYLHQQHPSSLLSSSPTTTINTFRLASTTTTTTDTTNTTPDITNHYTIFKQTLPAGPPPSSPFDIPTADLRREFLRWQSLIHPDKYPQGPQKQQAEALSARINEAYRTLLDPLQRAQYLLREMHGIDVTAEDGASKHALDAETLMEVMEVQETIEEVTDSGEDAAVAEQKINELKVENQGRVEECVRVLGEAFDKGDVELARRECVKLRFWYSVGEGLREWEPGCREIRLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLZ4</accession>
    <name>A0A8G1VLZ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_36769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515182.1">
        <property type="nucleotide sequence ID" value="XM_025655829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLZ4"/>
    <dbReference type="GeneID" id="37159231"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="90" mass="10985" checksum="1DA881554358EA37" modified="2022-01-19" version="1">MNFLCIRSLSILSFFFFLSVSLYDCLWVICLYCMRIISFLRLFFFFLWRLYLCVWVCLVRPCCVLFITLIFRAFRHWSDGVGWFMSAETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMF1</accession>
    <name>A0A8G1VMF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nucleotide binding protein Nbp35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NBP35</name>
        <name evidence="12" type="ORF">BO85DRAFT_448625</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMF1"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904564">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly scaffold complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000427">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="84"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH58611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="343" mass="36485" checksum="C591F431FFB80C91" modified="2022-01-19" version="1">MAPSLEEPTAAYLEARSKMAPNLVAPEPEHCPGPESEQAGKGDACAGCPNQSICASAPKGPDPDIPIITERLSQIRHKILVLSGKGGVGKSTFTSLLSHAFAANPESTVGVMDTDICGPSIPKMMGVEAETIHVSNAGWSPVWVTDNLATMSVQFMLPNRDDAVIWRGPKKNGLIKQFLKDVDWGEMDYLVIDTPPGTSDEHLSVNSLLKESGVDGAVVVTTPQEVSLLDVRKEIDFCRKAGIRILGLVENMSGFVCGSCNTKTQIFRATTGGGKRLAKKMGIPFLGAVPLDPRVGMACDYGESFVDHYPDSPASIAIKQVVRSVAGMIGEDPNDVLPEDVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMI4</accession>
    <name>A0A8G1VMI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF775 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_280837</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516653.1">
        <property type="nucleotide sequence ID" value="XM_025655198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMI4"/>
    <dbReference type="GeneID" id="37158600"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="158"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH58731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="221" mass="23950" checksum="5BDACD13B153D4DF" modified="2022-01-19" version="1">MFSVIIPDHPCLTDIVAVETQPNGQTTKFAFNFPLPPKLTELVVFFLPGTVLPPDTAAAIYIQFPDPNNNAPQFKFIGALANERPSAILKVQAPQIPGLQNGNAMAGAAPMVTLGISLEPVQAVAPQVAALEAEQAGGGAGQSLELVRHNRQQKEITTKVLAQRIIGNAFNFLASFASEDPSNRGQETVPLKTFRDWWTKFERKVEMDPTFLEREDPSASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMM3</accession>
    <name>A0A8G1VMM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">7-dehydrocholesterol reductase</fullName>
            <ecNumber evidence="17">1.3.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Sterol Delta(7)-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BO85DRAFT_447915</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.21" evidence="17"/>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516788.1">
        <property type="nucleotide sequence ID" value="XM_025659809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMM3"/>
    <dbReference type="GeneID" id="37163211"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047598">
        <property type="term" value="F:7-dehydrocholesterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016132">
        <property type="term" value="P:brassinosteroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056230">
        <property type="entry name" value="TMEM62_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF38">
        <property type="entry name" value="7-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24394">
        <property type="entry name" value="TMEM62_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="12 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM62 C-terminal" evidence="21">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF24394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RAH58866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="471" mass="53293" checksum="42CBD95503F13189" modified="2022-01-19" version="1">MPWGPIQSREFSAKAVDMNAMKFQGMDVKSSKASKIQDGLPKPKIHLVLMSFIFCVTTPLTVLFYCIAYQDFDTALSATAKSAYSEGFLHFFLKRTPLPTFEATRGYAAWLTFQGLLYIALPGPTVFGPPTPAGRRLRYKLNGLAAWIVTVCLAVSGSFAGILSPTALAKTWRELVAVTNIFSFIILLLFQIKARVAPDNAYETYITGSFWYDLFEGSELHPRVGQYWDWRHFLSTRSGGIIAWTLIDLSFAAYQYEQHGYLTGTMFTVVLLRAVVVVDFFVNEEVFFHTLDGKYESFGFYNIYGFSAMMPVFWTLQTQYLAKHPTEISLPALIASIVIFVAGWSLRFYADRQKMRFNRTQGKCLFWGRQAQGIPVSYQTRDGKTHRSHLLCSGLWGVARHVNYAGSVLYTWSLCSLCGNGGGFAYTEAVLVTGMIIHRCFRDEEKCADKYGSGWDEYCRRVPWRIVPGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMX9</accession>
    <name>A0A8G1VMX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WW domain binding protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_263530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517103.1">
        <property type="nucleotide sequence ID" value="XM_025655040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMX9"/>
    <dbReference type="GeneID" id="37158442"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="297" mass="33283" checksum="4C8DD45C8405228A" modified="2022-01-19" version="1">MPKDKERSLNPAAAQRKLDKQKSLKKGKAEAQARRNEKLARRNPERIQRQINDLKAFEESGQKLRPRDQELLEALERDLRAVQKAREALGDKAPKFNNFESRRGGQHRGRGDAAVLGKRRRDGGDGNRFRHDGDDGSSSSDETDEEVRRIPMPRDTPPPIPRQYRKGGPGGEAEGGGGRGPHALPAKPPVVEAKTVYEAKPEIRNLRQEAINKFVPAAVRVKQEAIRGQGKLLEPEEMDRLEQAGYNAGPAEGEEKASSAAPAADDEDTQRRLEEEERRFNQELRSVQIEEVEDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN05</accession>
    <name>A0A8G1VN05_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_271079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516202.1">
        <property type="nucleotide sequence ID" value="XM_025655088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN05"/>
    <dbReference type="GeneID" id="37158490"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="55" mass="6500" checksum="937BE948DF6AC74C" modified="2022-01-19" version="1">MVTLKLPNYQHVLFTKSMFQPHPCILMQHQRDALFFLINTIVIFIFSHSKLLQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN17</accession>
    <name>A0A8G1VN17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_512035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517223.1">
        <property type="nucleotide sequence ID" value="XM_025664634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN17"/>
    <dbReference type="GeneID" id="37168036"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="264" mass="28893" checksum="3021A9CF562697BC" modified="2022-01-19" version="1">MSASKPVILLISGGWHVPTSYDKLTNLLKSSGHEVHVPELPSMNGARPPTADLETDTTAFREYALNLANAGKNVIVISHSYGGQVATNSLSDLAISNRSKQGLPGGVLHIVSLSSFTITEGRSMFDIVDQFGHASLMPVAFDFAEDGTCVDRDPKGLLVTPGPDESESEVEWYLGTLQRWNGKCMYQPITAERAAWKDIPVTCVLSTRDMTVPVDYQRWMVDVMKKEGAEVEAFELDSGHSVDFSKAKEVAEIVNNVVARYEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN65</accession>
    <name>A0A8G1VN65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_447379</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517388.1">
        <property type="nucleotide sequence ID" value="XM_025659711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN65"/>
    <dbReference type="GeneID" id="37163113"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000198">
        <property type="entry name" value="Deoxyribose-phosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="9">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001357-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH59466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="253" mass="27086" checksum="F48C990994BD8F64" modified="2022-01-19" version="1">MTLPQLAKMIDHSLLHPTMTDADIIAGLKIARDNHVATACVKPYAIPLAKKELAGSDVLVCPVIGFPHGNSTTEIKVLEATAAAKAGGAEIDMVVNVGKVLGEEWDYVAEEIRQINEAVVSNGAVLKVIFENDYLRPEHIARLCEICTQIGVAFVKTSTGYGFVKQPDGAYNYRGATVQTLKLMREKSGEKVQIKAAGGVRTLDDLLHVMSLGVTRIGATATVAILEDARKRGVGNEPVEVEFKPMAEASGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNA3</accession>
    <name>A0A8G1VNA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nudix/MutT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_245702</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517508.1">
        <property type="nucleotide sequence ID" value="XM_025654883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNA3"/>
    <dbReference type="GeneID" id="37158285"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000046">
        <property type="entry name" value="Nudix/MutT family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH59586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="162" mass="18255" checksum="7D499890E25C3A10" modified="2022-01-19" version="1">MFKMADHPRSMESRVGRKNQRYGPKGERLVAGVVPLSADKTKVLMIQSAGRGGWVLPKGGWETDEVSAQQAACREAWEEGGIICTVHKDLGLIPDMRPSTLLTSSAPKASYQFFEVTVDREEDQWPEMHKRKRQWVTYAQAAESLASRPELLEALNRSSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNE6</accession>
    <name>A0A8G1VNE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_280004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516622.1">
        <property type="nucleotide sequence ID" value="XM_025655187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNE6"/>
    <dbReference type="GeneID" id="37158589"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="96" mass="11172" checksum="9012A8252B2A1B8A" modified="2022-01-19" version="1">MPRNLPPTQQQSHDQNHGRPQHTPIFPPVQYLDHQHEAPRPQSQQPDATTTFLKPTSLTSTRSQTPDMTYPTVKATRHLHLHTYIHTHTHTHTYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNJ3</accession>
    <name>A0A8G1VNJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pre-rRNA processing protein Rrp12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_368310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517778.1">
        <property type="nucleotide sequence ID" value="XM_025655862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNJ3"/>
    <dbReference type="GeneID" id="37159264"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="12"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="346"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1012"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1120"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="675"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1020"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1053"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1075"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1209"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1239"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1250"/>
            <end position="1274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH59856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1274" mass="139105" checksum="DD34BE2AC2D671EC" modified="2022-01-19" version="1">MATLAEKLEKIKSPKLQNQHHTAVVLSAVEDTLRDQKADFSPTAYFAALLALLSQSISATQGIVNKDLATSVVYLLDITTAYVPASILRAKFSQILTGLAPALSLPEVDAPLLRPSIGCLESLLVAQDVAAWNLPHTQIGPRRAIAGLLSLAVDHRPKVRKRAQDALVKVLKSPPPSPSLDHPAADMCAETAMRTLSDSITAAAKSKRGRHDSSGRDTHDPLVIHSLQLVKTLAVASGGWPSKKIEPLCELLMNASRSTNEFITMGAFEVFEVIFSSMADEFSSSKLPRLLEAITDLKPAQNDSQLLPPWIAVLSRGYDVSAQTSPEDTFEKLPALFNMVSGYLASPSSNIRVSASECLVSFLANCIPNSVIIEPSVYDEKTLEKIAKAAMDLLSVKYQAAWREVFNVCAALFDSFKWRSSPFLDDIVKTVGELRSNESFQGKKEADNVLGSAIEAMGPAAVLEILPLNIIEQKNGQPGRVWLLPVLRDNVTNTDLAHFRSEFVSLSEALYQKVMEFSAREKAVEVKIFETLVQQTWAILPGYCELPLDLTESFDQGFAELLSNVLYKQTDLRVDICRALQNLVESNQAILSVEADEDDLILQRRITKKAAEKNVAHLAGFASNLLAVLFNVYSQTLPHYRGYILQCINAYLSIAPEKELNETFERVTSMLESSVVSETETAKQGNQQTGSGDKMPPTSHTLIDLVIAMSIYLPRTSFANLFGIAAAILNGQTGDQQLIKKAYKLIPRLAQTETGSAALQERSSELQALILGTADKTPASARRDRMLAIYELITYLPTSDLHFIPSVLSEVVLGCKESNEKARTASFDLLIHLAKRTTDEEKNPAGTKIRNSLVPHMPNDAPDAPATIEEFFTMVSAGLAGSSPHMVAASVTALSRLFFDFHTQIQPTVRSDLVQTVELFLTSNNREIVRSVLGFVKVAVVVLPDEDLRARLSSLVPNLMVWSKEHKGRLRSKVKGILDRLIRRFGAAPIEELVGEADRKLVVNIRKLRERRKKKKNAEQDGEDDEENDEPAGQEEKSGRSYSNAFDKAVYDSDLDSDDDASEIDVDEEGVTHALKGRKGKRSNKQSEQYIREMSPEDNPLDLLAPDALANISTTKPSVRFLNTGPGSRKKRNAKVDSDGRLILGDDDEDVDMSAGLDNNAGESGINAYVQAVSGPDAVRRGQRGKLKMAQSQKKKGGDDMDVDDDNDNNASGPASRPGPGRRGLGMPKTHGPSGAGRIQKRMPMRGRPGRGGSRGGSRGGGRGGGFRVGGNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNK7</accession>
    <name>A0A8G1VNK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_487418</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516624.1">
        <property type="nucleotide sequence ID" value="XM_025663452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNK7"/>
    <dbReference type="GeneID" id="37166854"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="4">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="35"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH58702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="109" mass="11983" checksum="7BDA5BB3FAABBEDA" modified="2022-01-19" version="1">MSHNVVDIKSKAEFNEKVLGESTGPVVVDCFATWCGPCKAISPKVEQFSNEYPNAKFYKIDVDELSEVAAELGIRAMPTFLLFKNGQKFDDLTGANPKGLEEKIKALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNW7</accession>
    <name>A0A8G1VNW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_221211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518108.1">
        <property type="nucleotide sequence ID" value="XM_025654700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNW7"/>
    <dbReference type="GeneID" id="37158102"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034423229" evidence="1">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="77" mass="9015" checksum="B35EDACB69FAA872" modified="2022-01-19" version="1">MEMSLLLLLGVEIDGLHAYIVLGFAYQNTSIFVETCSIFFFHNDVKLRYGYYKYIYMGYSKERNASYCTTHLAPNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNY6</accession>
    <name>A0A8G1VNY6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_35463</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515125.1">
        <property type="nucleotide sequence ID" value="XM_025655488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNY6"/>
    <dbReference type="GeneID" id="37158890"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF16">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034909299" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH57203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="574" mass="62835" checksum="5A40898BA6D218A5" modified="2022-01-19" version="1">MRSPAWASIAITAFAALANAGTPSTLAELCTDSIVKAALPPSEFIQGITIDSDSVTTEVVTNSSFSSEFYPSATIDYCNVTFAYSHDGIDGDQVLLEIWLPAPTNFKNRWLSTGGGGYAINSGDQSLPGGVMYGAASGMTDGGFGGFSNNADTAMLLANGTLNYETLYMFAYKAHRELSLLGKALTRNVYGMSDSDKLYAYYQGCSEGGREGWSQVQRFGDEWDGAIIGAPAFRWSFQQTQHLYSNIVEKTLDYYPPPCELDKIVNETIAACDAMDGKVDWVVARTDLCLLDFDISTIEGKPYSCAASRGTPAQNGTVSAKGIEVAKTIINGLHDSQGRRVYFSYQPTAAFDDAETQYNSTTGQWGLDIDQLGGEYIALLVDKNGTTLDSLDGITYDTLKDWMISGLQEYYSTLQTTWPDLTPFHNAGGKVIHFHGDADFSIPTAASIRYWESVRSIMYPNQDYNSSAEALNEWYRLYTVPGAGHCATNDAMPNGPFPQTNMAVMIDWVENGVVPTTLNATVLQGENEGQNQQLCAWPLRPLWTNNGTTMECVYNQRSIDSWHYDLDAVPMPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPH9</accession>
    <name>A0A8G1VPH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_414330</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518931.1">
        <property type="nucleotide sequence ID" value="XM_025657644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPH9"/>
    <dbReference type="GeneID" id="37161046"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000024">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041083">
        <property type="entry name" value="AAA_lid_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048867">
        <property type="entry name" value="WHD_ORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17872">
        <property type="entry name" value="AAA_lid_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21312">
        <property type="entry name" value="WHD_ORC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="12">
        <location>
            <begin position="97"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="260"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="587"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH61009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="804" mass="88844" checksum="A48DA82CEAC1A995" modified="2022-01-19" version="1">MASDSADEADKSRSRKSSVRKRAQLWMTKGGLVRDDSDDELGDEDHPWEWIYDHNDENNNHSEQATAEDTPKSSRRRTPRPNAKRRRTIVGARMGSFECALGQVVLLKSPEPGKVWIGIITEFLEQEDPDAEEEVIKSANIMWFVSPDEFMSTRNKRRTDALPNEQYLTADFNVNPLTSINGKATVMSKDAFYAKYPDGVPPKGKEELAEFNKCIVVRRGVNQLQGRYTEEFVWEDVYREDRVFDLITLIKDGLKAAKKRKQVDEDYDEKKDNTKEEDEFVPTTPRKRQKVATNATPQSRRQKTFTTPAHKRIVVKKPLEFTPLGTRVLSPTHFASPYRQARTLLHVSTVPTSLPCRKTEFETVYSHLSAAIVEGTGACIYISGTPGTGKTATVREVVAQLNSAVLAEEMDDFIFVEINGMKVTDPHQSYSMLWAALKGDRVSPSHALDLLEREFSHPSPRRVSCVVLMDELDQLVTKNQSVMYNFFNWPALRHSRLIVLAVANTMDLPERTLSNKISSRLGLTRITFPGYKHTDLMEIISTRLANVPGNIVDADAIQFASRKVAAVSGDARRALDICRRAVEIAEQASEAAAQDPDTDKPDADDTESLPPTPSKTPARRERSLKQSAQSSPQKKPPTKPQTVGRVTIATIKQAIHEATSTPLQQSLRCLPLAAKLFLAAMLARVRRTGISESAFGDVIDEAKRIADAAVAVAGAAGAGIKEFLLAGGTGARVRALGYAAMELTNSGVLALEYGAGAKGPLGSAAIPYRGDRSGKVRLRIAAEDVKIAFREDDEAKGLGLGLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPS9</accession>
    <name>A0A8G1VPS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">O-methylsterigmatocystin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_220848</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518077.1">
        <property type="nucleotide sequence ID" value="XM_025654693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPS9"/>
    <dbReference type="GeneID" id="37158095"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH60155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="528" mass="59270" checksum="C4053ED3E736F8C1" modified="2022-01-19" version="1">MSLLVRAIVGLLGLVILKSFLTRKRFPAPLPPGPKPKPIIGNLLDLPANGEADWLHWYKHKKTYGPISSVQVFGETLIIINDARIAVELLEKRSATHSDRPSLTFIEMCGFKDLFSLRNNNDPRVRTERKLFYQQIGSNNSVARFNHIQEAEVGRTLLRVRDNPEGLQDHIRKQAAAIILKVAYGYSVVPHGDDPLVDLIARAMGNLGAALVPGVWIVDFIPFLRHIPAWFPGATFKRVAENFKESARAWNCQPYEFVRHQMSQNKHAPSYLSGLLEAKGVPEPGSFDEIVMKWSAAAMYGGGSDTTISTLGGVFLAMVLYPDVQRKAQEEIDRVVGTDRLPSFSDRENLPYIDAMVKEALRWHSVTPMGVVHSSSEDDMYEGYFIPKGSQILPNQWAFTHDPDVYPEPMAFKPERFLATENHAPERDPHLLAFGFGRRICPGRTLADSNVYLSIAQSLAVYSFTKPIKNGKEVDVEPKFLNGVISHVAPFEVGIQPRSKQHEALLKELEIKYPWEEGHAAELSQVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ71</accession>
    <name>A0A8G1VQ71_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1766-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_411962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519458.1">
        <property type="nucleotide sequence ID" value="XM_025657549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ71"/>
    <dbReference type="GeneID" id="37160951"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053006">
        <property type="entry name" value="Meiosis_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF2">
        <property type="entry name" value="BACTERIOPHAGE T5 ORF172 DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="279"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="407" mass="45126" checksum="1FD10EB88835DBB5" modified="2022-01-19" version="1">MPIIANTPEAVLGRTDSLDPATTCRGVTSNGRPCRRALASPSPSETPASKSQQTDLSAMYCWQHKDQAASVLQTNSGANPSRLRPRGSIDTLMERLGLMDLNDAGTSDKRRRQRKPTPKKRTRRTICCCFEVIEEEDIRPSRPVNAPTEMQQAPAGKLSTPTPSLSPHQVPVRPSKPGSSSSGTDDDILSWIPSGLAPETTSNLTAELSKPISEADEPGYIYMFWMTPSTSESKELPSSEVASNLMPPTSSPGRDRRVSDAIRTARDLNALASAPSHDSPGTLRLKIGRANNVQRRLNEWSRQCGHHLTLIRYYPYTPSTPQPSPSRHGRSNDDSTATLVPGRKVPHVHRVERLIHLELGDVRIRDLGKCPDCGREHREWFEITAEKASLKRVDDCIRRWVKWAETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ89</accession>
    <name>A0A8G1VQ89_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_448538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516430.1">
        <property type="nucleotide sequence ID" value="XM_025659960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ89"/>
    <dbReference type="GeneID" id="37163362"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="233" mass="27670" checksum="24537A36610C2ECF" modified="2022-01-19" version="1">MSLDPLPNRNPTPPPTLSPSPIRVLVQTLTHLVPSTNEAGEKNIYDDKLFTMLDAICQHTWKCDFDGHVHRWYTYGDEFGYSHRMCFFLIDYGTAPGGDDSKVPIVCYEWDGSKFIDKPQILQFEDVQAELKSVPFTPAPYEPSEKPPVRDIVRRMLRSARRIPVRELDHMRDHPEDMEWLERKVKPRFWTSFLEQLRNIEKTREWEEEQRIMRREFEEEEAKQKEIESMGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQC1</accession>
    <name>A0A8G1VQC1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CAIB/BAIF family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_365761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518514.1">
        <property type="nucleotide sequence ID" value="XM_025655754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQC1"/>
    <dbReference type="GeneID" id="37159156"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF1">
        <property type="entry name" value="ALPHA METHYLACYL-COA RACEMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="562" mass="62964" checksum="593065A1E69AA65E" modified="2022-01-19" version="1">MYRPSEEARRIFDLLRQNSERLGLPVDILTSQVEFHSYSDTIYYPIPFKVTETLAALKGIEGALAALIADLQTRPKPHERKTTINLERATLFGFQALVTKINGYSRSDPEVKRYLKDTDIHAAQSNPYRRMAASMYQTKNDNEFFHLHGSLNPTPTLNMIGLDSHCADLTDYDEIINTIQSQVQKFSAAELETLNETYRQAGVTVYEYEEFKNTPHGRTSIQEPWWKVIRLPGETPPALFNPSESPRILEGIKVLELCCVIAGPIIGRTLAEYGADVLKITSPTVPDVPFFQVDNNMGKCAVELDLKTDEGRRQFEALLADADVVIDGYRPGVLRKLRYSPESMAAMAEKRGKGIVYIDETCFGHEGEWCHRPGWQQIADCLTGFARCHGRFLGRVEPMVSPLPIADSGAGCMGAIAALTGLYNRARYGGSYIGQVSLMQFNLLLYASGKYPESVESQLQKSFAPAFSKIRFCDSVGRSSVLALEVMRERFPYLFVEASPEDRQKNLTEVWYSHHYGADVEVVRPVAEIEGVVNGFSRATRPNGADASPSWDFPEEQGSRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQJ9</accession>
    <name>A0A8G1VQJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_120815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519833.1">
        <property type="nucleotide sequence ID" value="XM_025653908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQJ9"/>
    <dbReference type="GeneID" id="37157310"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH61911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="103" mass="11359" checksum="D2623FEC138EBA56" modified="2022-01-19" version="1">MLSCFMFSLAGNCGTSLLFLEHPPPFSFLLLAILCTCYSLTDNEYAVVSHSLDIICGVDRLPTFAVMESMGGVAVNLNEQRARNPGIAELRHYAPTFFILVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQU1</accession>
    <name>A0A8G1VQU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_188117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519039.1">
        <property type="nucleotide sequence ID" value="XM_025654407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQU1"/>
    <dbReference type="GeneID" id="37157809"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="80" mass="9216" checksum="355BE39BEDA13DC9" modified="2022-01-19" version="1">MRRSIPYPIAHCLSLLSGSRVMSSRCLKGTNDHDSRATVFFSFLFFLFFNSHAFYPTHPPFCSSPPPLSLLSLLTYRYYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQV4</accession>
    <name>A0A8G1VQV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_448116</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517090.1">
        <property type="nucleotide sequence ID" value="XM_025659870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQV4"/>
    <dbReference type="GeneID" id="37163272"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000071">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="11">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH59168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="149" mass="17304" checksum="C7099CD9BDC1FD56" modified="2022-01-19" version="1">MPKNKGKGGKNRRRGKNENDNEKRELVFKEEGQEYAQVVKMLGNGRLEALCFDGEKRLAHIRGKLRKKVWINQGDIILLSLRDYQDEKGDVIMKYTADEARSLKAYGELPEHAKINETDTYGHEGFEDNVEFDEDRESEDEKEIDVDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQW6</accession>
    <name>A0A8G1VQW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_446347</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519114.1">
        <property type="nucleotide sequence ID" value="XM_025659484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQW6"/>
    <dbReference type="GeneID" id="37162886"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017016">
        <property type="entry name" value="NDUA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="CHCH" evidence="10">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH61192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="141" mass="16173" checksum="8BD7741E9CB505D4" modified="2022-01-19" version="1">MPDHIPKVEEIGATSAPLYSAAYFIGDRCKPYNDDFMKCKDESNGRGELDCLKEGRKVTRCAASVIKDINTHCLKSFTAHWECLENNNHKLWECRAQEMKLNSCVFEKLGLKKEIPGTPENVVPVHLRPKQIYSDWPGRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR87</accession>
    <name>A0A8G1VR87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-methyl transferase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_494179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520731.1">
        <property type="nucleotide sequence ID" value="XM_025663861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR87"/>
    <dbReference type="GeneID" id="37167263"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="56"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="159"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH62809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="380" mass="42964" checksum="EBF5979A2C5FC20F" modified="2022-01-19" version="1">MEALTQEVRRLVEAGDEITRKDVLDALHKLSVSIESPDDTVQRLTFYNMQLAGIRIGIDLKLFELLLEGPLTVDELSQKTGANQVFLARILRYLASYYAVEEVSKDTFTASNISKTFAVSGHQAAVGHMWNNCGQIIQILPSWLKENNFPDIQDNVKTPFQKALNTDVPAFIYMQQNPEALGYFVEHMMSNRAGMPTFLDAYPVLEKATGLSPERALFVDIGGGLGHQAIGFKQRYPQLEGRVIVQDLAQTLAHAIDFPGVEKQTYDFFTPQVVKGAKFYYLRNIFHDWPDYKVLEIIKNIIEAMAPDSYLLIDEMVLPNTGVHWQQAQLDMLMMATLGARERTEGQWYRLAEEAGLTINQVYTYTMSLRDSIIEAVPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VS58</accession>
    <name>A0A8G1VS58_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">E2 ubiquitin-conjugating enzyme 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_443956</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520537.1">
        <property type="nucleotide sequence ID" value="XM_025658908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VS58"/>
    <dbReference type="SMR" id="A0A8G1VS58"/>
    <dbReference type="GeneID" id="37162310"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH62615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="166" mass="18600" checksum="B6EE3B05B0734740" modified="2022-01-19" version="1">MSSVAQKRLFHEYKNLSTNPPEGITAGPVTEDDMFHWEALIQGPEGTPFEGGVFAAELKFPKDYPLSPPTMKFVGGGVWHPNVYPNGTVCISILHPPGDDPNHYEHASERWSPIQSVEKILISVMSMLAEPNDESPANVEAAKMWRERRGEYERKVRDEVRKGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQR7</accession>
    <name>A0A8G1QQR7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_508089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510015.1">
        <property type="nucleotide sequence ID" value="XM_025664439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQR7"/>
    <dbReference type="GeneID" id="37167841"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="400" mass="45589" checksum="88C7910F70CD4BDE" modified="2022-01-19" version="1">MNHPYRTLLFDRWKKLICFQLQKQATTCIVPSSENTDSNIILAASKALSTSIMSRGFPERVSGVDSTHSYLNALKLMRKELSTAKMSSDRELLASIMCLSLAEVMFPGPSEGLKMHIDAVAQILQANGPQRYQTGVAHRLFIGFRPLLMINAIQCRNPSFLGSDNWKTTPFAILSPSPMQSLLSQAAALPTILHTLDNLSSPGASNQNQCECIRILKCFEDLLNRLDEWEASEFNNATSPLYWYRDQDAEEIPCIWFPSITMANAITYIWAFRIICLCEMERLSSYLPQRSFEYLRILKEQQIESVQKSSETLMRQICESMEYLLQEEMKLFGPASTILPLQVAYAVATMNGNQHSAQLPILKRIVERLVLKGLQSFPMLIFERNSFLHRWDRLSDRQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QR20</accession>
    <name>A0A8G1QR20_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_454142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510165.1">
        <property type="nucleotide sequence ID" value="XM_025661211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QR20"/>
    <dbReference type="GeneID" id="37164613"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="72" mass="7852" checksum="F06C9EA6532662A1" modified="2022-01-19" version="1">MMGQGFCLWGLGNREPEAALSGTQRVLFSCGVWILSGSPPSLRQNCRFQSDRAEPYHDRASVSPGVGVTWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSJ5</accession>
    <name>A0A8G1QSJ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_454569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825093">
        <property type="protein sequence ID" value="RAH51794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509716.1">
        <property type="nucleotide sequence ID" value="XM_025661318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSJ5"/>
    <dbReference type="GeneID" id="37164720"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034723141" description="CBM1 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH51794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="8811" checksum="94F9BC6848302C15" modified="2022-01-19" version="1">MRPWTNTIVALLFMGAAGATGIGPCYNHADPQHNIGNYCYCQRNGVCYFEGIHNSCDPPGNAIPGGCPKNMIRGGLRLRTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT23</accession>
    <name>A0A8G1QT23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_408345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510224.1">
        <property type="nucleotide sequence ID" value="XM_025657396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT23"/>
    <dbReference type="GeneID" id="37160798"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034541459" evidence="1">
        <location>
            <begin position="18"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="184" mass="19230" checksum="A0FDB9FC7ACC28F9" modified="2022-01-19" version="1">MKTSLATAVILFTSVLAAPVPKGNANNENANAKVEIPTSPGPVCTDTEICPYEVSDSQYARRQEPIPAHAQGSLIGGGLGRRQEPIPTDAIISLAGGGLKRRGDEDVPAEVLASLLGRRQEPIPTDAIISLAGGGLKRRGDEDVPAEVLASLLGRRQEPIPTDAIISLAGGGLKRSEEDVMDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTJ1</accession>
    <name>A0A8G1QTJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosducin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_405752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511515.1">
        <property type="nucleotide sequence ID" value="XM_025657310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTJ1"/>
    <dbReference type="GeneID" id="37160712"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02987">
        <property type="entry name" value="Phd_like_Phd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001200">
        <property type="entry name" value="Phosducin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="133"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH53593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="278" mass="30953" checksum="A966D2BA777D9E89" modified="2022-01-19" version="1">MSSAQDEFNQLINNNREKFSSHPEDRDNDSVHSSDASSDHDEPQFSDAEDTSSAMHSRNPSSYRVPNTVFDANTGPKGVIADAQAFERARKSSFRRTLLGVAGLDRSHYNKSVNDDATLLQNSSPPDGSSASDDEERFLHQWRAARMQEMQARSLRKPSPRRKLYGSVDIVDAVGYLDAIEKVTSGTVVVVCVYDPESTTSSIVEDSLNTIARRQPTVHFVKLHHEIAEMDHIEAPALLAYKDGDVFATIVEILRQIPKGRSCSADSLEDLLRSYRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTQ2</accession>
    <name>A0A8G1QTQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_504164</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511400.1">
        <property type="nucleotide sequence ID" value="XM_025664284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTQ2"/>
    <dbReference type="GeneID" id="37167686"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="42"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH53478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="470" mass="51422" checksum="E6FBAE4FF10F42E1" modified="2022-01-19" version="1">MHSITPSEVIKLRQLLAGTDADVLTEGEPGYAEGIRRWSDTCEKKAGAVVLPTTAEEVSAAVVFASNHQIPMVVHNGGHSTSGASATEGGIVISMTKMRRVVVDPERKTITAQGGTVWEDIDRAAAPYKLATVGGTVNHTGVGGLTLGGGYGWLTGRYGLTIDNLLGATVVVADGRILKTSETENPDLFWAIRGAGQNFGVTTEFIFQAYDQTNEVYAGLLSWPAQCLPQIIEFVNHFEDDTNKGDMGIFFGFCGAMPPGRVSIVAAIFYNGPQDEAERQFDPILKLGPTINTAKMMPYEQLNSIQNPIATYGGRKSFSGAFVKLPLQVEFFQELLEDYGTMIKTYDGVSATAVLFELVSHKKAIQVPKDTMSYSTRGPWYNVGCAFRWEDPSLDKTMRETQRALMRKVGDRAGGGAHARAYANYSHSDGRAKDVYGDNLPRLQKLKKQYDPKNVFKKWLNLLPEEDVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QU08</accession>
    <name>A0A8G1QU08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_462840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511755.1">
        <property type="nucleotide sequence ID" value="XM_025661873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QU08"/>
    <dbReference type="GeneID" id="37165275"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="80" mass="8836" checksum="7EC6003B700010C6" modified="2022-01-19" version="1">MIPVKQNNCQHVTPIIQLHVSNIPTTPGDLVDYGDFKEKSAHINFAGHTEDAALCTVLHKTGEDSNAVWDTAYDNTLPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVA9</accession>
    <name>A0A8G1QVA9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_337591</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512225.1">
        <property type="nucleotide sequence ID" value="XM_025655449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVA9"/>
    <dbReference type="GeneID" id="37158851"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="4">
        <location>
            <begin position="191"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH54303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="378" mass="42807" checksum="2FFBF2742F673186" modified="2022-01-19" version="1" fragment="single">MAYPYIDTPRTEVDGNATYLTGYRSVGRPNLTALDSVENSFATPSKDDDLLKGLGDGRRRTSGSFKTHTPRAGAASKSTRSALNSRHQLPTAAPPKGEFTPLMRSATKNNYLRNMSTTRGPKTPGHIGRSYLSNGNTPGLPGMEMTDIDEEDATDDQPTPIPQVASSSVQSTPLPGLSRNGGVLNEGNNMTLKEQEKMIDQLDKDNFGLKLKIHFLQEQLEKAGPAYNQAALKENTELKVSKLTMQRDISRYKKSLQQAERDLESYRIQFQELREKARGRPTDDTIQREMDLMREEIESRDNQIRELQEDLRDAKDSQSQEMEKLRDEVEDLEASVRERDRAIEERDEEIEELKDRDGKERDALTELESELQRAKEQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWD0</accession>
    <name>A0A8G1QWD0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="9">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_451753</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512801.1">
        <property type="nucleotide sequence ID" value="XM_025660663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWD0"/>
    <dbReference type="GeneID" id="37164065"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="532"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH54879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="565" mass="61234" checksum="F57463D93BBB11F4" modified="2022-01-19" version="1">MAFAGQAPTIIVLKEGTDTSQGKGQIISNINACVAVQSTIKSTLGPYGGDLLMVDGNGRQTITNDGATVMKLLDIVHPAARILTDIARSQDAEVGDGTTSVVVLAGEILKEVRELVEQGVSSQTIVKGLRRGSAMAVNKIKEIAVDVIESAGSEEKKVETLRRLAGTAMNSKLIKRNSDFFTKMVVDAVLSLDQDDLNEKLIGVKRVTGGGLQESLFVNGVAFKKTFSYAGFEQQPKYFKDPKIVCLNVELELKSEKDNAEVRVEHVSEYQAIVDAEWQIIYNKLEAIYKTGAKVVLSKLPIGDLATQYFADRDIFCAGRVAADDMDRVCQATGAATQSTCSDIQERHLGTCGIFEERQIGGERYNLFSECPKAKTCTLVLRGGAEQFIAEVERSLHDAIMIVKRALRHTTIVAGGGATEMELSSFMHGFADRNVPHKQQAVVKAFAKALEVIPRQLCDNAGFDATDILNRLRVEHRKGNVWAGVDFDHEGVRDNMAAFVWEPSLVKVNAIQAAVEAACLILSVDETIKNEESAQAQAPTRGLPPGAAQRALGGGRGRGMPRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWM3</accession>
    <name>A0A8G1QWM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_491678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511876.1">
        <property type="nucleotide sequence ID" value="XM_025663730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWM3"/>
    <dbReference type="GeneID" id="37167132"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="628" mass="70237" checksum="4D67A94253A594DB" modified="2022-01-19" version="1">MSASPYMADPLTVLPPEIVLRVVEFLPVSAVASLTAVSKPWHQFIDITHREAIYSSESKTAQPPGGARDFSFLSNSTTSFTKLFENPTSWKDLCKRQKLLARNWAAERPVTRESVLQVGNNPVWRFRADFKRRFFISTSHAGGLNVTDMDTGKILWRLPSTLERDEGSVRPYAHLEYQDGMAVFDREGDALEVWQADQEGAKRGEFRRIAILDHNCQTRGFQLSYWTLCVVSTQGQGFVYDMTQRPPKLTTHISIENDAVGHLDQSADAVIYSMGPRGYHIYNKATGEFLGALQPFRCTDMYHILPPVATSPSAIAALAAAARHGPTQQMVALSKPRKDCLVPIELSKGPLPPPTDFEHVRHGDDEWGAGMLHGDLFVGFSRAGRVFVCSNWRKALQTENGISEHGSLIECESDGSNFDLGGWLSVRNHRVMFEIQDRIYVVALDDDNKIQNVNNPARASYSLLTSSVPQLAVPVSFMALYDDAIMTTYTTLGFRQHNADIPDDDQDEGPARIFPTKAIRIVSLAPDLSDGKSVPVDDQQATGEGLWSSEPRQRRTEDNWRSQAGLLQLVSLLGDELDDEDEAEMEALARENEEEWEDLEDDDFDDHDHDHEGDEESEPESTREHGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWS0</accession>
    <name>A0A8G1QWS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_471282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511951.1">
        <property type="nucleotide sequence ID" value="XM_025662465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWS0"/>
    <dbReference type="GeneID" id="37165867"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05289">
        <property type="entry name" value="MDR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="18"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="357" mass="38480" checksum="C618F8F64E0B7C9C" modified="2022-01-19" version="1">MRSVYITEHTAPGQYQLGDVPSLVVEKPTDILIKVHAASINPIDVKKASGATKMVLKDSFPYKIGYDCAGTVVNIGSQVTRFQVGDEVFVRLPECHRGSWSELARSTEDFVALKPNNLSMEDAASIPLAAMTSLQALRGYEGDLAGKTVFIPAGLGGTGIFACQLAKNIFKAGKVITTVSTQKVPKVKELLGEGIVDEIIDYRKSDPKEVIPKGSVDFIFDTTGSAMEYLSLVRPKGAIITVSILTSGDVLQNSSVMRRSPDKNDKATVPFPLRIALNVMDRIRVARACRYGVKYASIFLEPNAADLNSIRGWVEAGKLKTVVGTKASFNDSKAVRDACQVVYDGKGGVGKSVIVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX45</accession>
    <name>A0A8G1QX45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF455 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_402178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513170.1">
        <property type="nucleotide sequence ID" value="XM_025657180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX45"/>
    <dbReference type="GeneID" id="37160582"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH55248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="356" mass="40081" checksum="0AB75F76627102FB" modified="2022-01-19" version="1">MQGFNMGRYVPPDLEGLTTGNKLHNKHPLGSRARNLQSTGALTVRFEMPFAIWCTTCQPHETIIGQGVRFNAEKKKIGNYYSTPVYSFRMKHGACGGWIEIHTDPKNTEYVVISGARRRDYGVDEEGRKVGEIITGGDSKGKMDALERLEGKVVDKKRGDEERDRILELQERQKRDWEDPYEKSRRIRKVFRAERKGLERKEEEREKLKDKLSLGIEVVDEIESDRVRAGLVDFGEGAVDGRRARMKPLFGEEEVRAGGGKKEGKRMKAKEVLEDRKAAFRSELRGNTRAAVDPFLSGDSDAWRPEVKRRKVVSGSKSGDGKESAENGSEMEKSSGEVGETPRPSLALVSYASDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX76</accession>
    <name>A0A8G1QX76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH-ubiquinone oxidoreductase 304 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_425862</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513215.1">
        <property type="nucleotide sequence ID" value="XM_025658095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX76"/>
    <dbReference type="GeneID" id="37161497"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="6 11" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="10">
        <location>
            <begin position="104"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH55293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="287" mass="32569" checksum="C5B438C3D353ABD0" modified="2022-01-19" version="1">MASARSLMRLGSGRSLATAVRSTRTFTTTALKATQASTAPISEDVPNMRQAQRPPSGPLRAPVINPADKYQDKADSLHKYGQYIMSCLPKHVQQFSVWKDELCIYVPPSGLIPTMTFLKYHTAAEYTQISDITGVDFPTRDQRFEVVYNMLSVRYNSRIRVKTYADEASPVPSVTGLFEGALWYEREVYDMFGVFFTGHPDLRRIMTDYGFDGHPLRKDFPLTGYTELRYCEEKKRIVIEPLELTQAFRNFEGGTAAWEPVSAGTDRTPESFKLPTPKPEPKEEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXB0</accession>
    <name>A0A8G1QXB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_82045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513199.1">
        <property type="nucleotide sequence ID" value="XM_025665704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXB0"/>
    <dbReference type="GeneID" id="37169106"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="104" mass="12391" checksum="7D1472422B5FD993" modified="2022-01-19" version="1">MWGLFSPQAYSWSDPLVLQLAKRTSSPLTPDQLPRFLALSPTIPLRQKVLDSYFSFILLFLMTIYRRARRSERIYLLPSMYDNLGEMLKRVKWKNSNQKYDQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYJ3</accession>
    <name>A0A8G1QYJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_460137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514693.1">
        <property type="nucleotide sequence ID" value="XM_025661700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYJ3"/>
    <dbReference type="GeneID" id="37165102"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001113">
        <property type="entry name" value="RNP domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001115">
        <property type="entry name" value="RNP domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="47"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="237"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH56771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="361" mass="37989" checksum="9727189E0E611A07" modified="2022-01-19" version="1">MSTAVENTTDNVASAPATTAPEATTNGTAPAPAQSTDAAAASADEGRRLYIGNLAYATTEGELKEFFKNYKIESVSIPVNPRTNRPVGYAFVDLATAQEATAAIEELSGKEILQRKVSVQLARKPEPAEAKAEGATSGGEGASGNEGRKRAGGRGRGRGRGRGRGGRLPRAGRSAPVQNGQEAAEPTNVPGQAAPLTEVTNQNETAAAAESKQAGKPRAPRPQKQRGPPEDGIPSKTKVMVANLPYDLTEDKLKEIFADYQPVSAKIALRPIPRFMIKKLQARNERRKGRGFGFVTLGSEELQNKAVQEMNGKEIEGREIAVKVAIDSPGKEDDAVAPAEAETTEQATETPAQENAAPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYM5</accession>
    <name>A0A8G1QYM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_488991</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514738.1">
        <property type="nucleotide sequence ID" value="XM_025663573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYM5"/>
    <dbReference type="GeneID" id="37166975"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.60:FF:000002">
        <property type="entry name" value="Protein-glutamate O-methyltransferase C1393.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="8">
        <location>
            <begin position="23"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH56816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="473" mass="53250" checksum="2BF710B11178B652" modified="2022-01-19" version="1">MEHDPQTPQYLTSDKSSFASVSAHERWPVILTGAIDDLHRSVADVTDEEKRQEGKAIIGDLAAFKYELQHNRQLTPLPDDGQPDIAAYNQELEQRGNPSWHNVAWLYSECYLYRRLSTFFSLSKHWKGYDVFARQKMSTFKSSRPAVLELAARYKELAEEASKGTDGKTPEQIEQADRILFSEMCEICLWGNATDLSLLTSLTYEDIQKLQGSEARKASEKNILVNDLNASFDVLHQARRDRKNQDRRVDIVLDNSGFELFVDLILAGYLLSAGLATTVVLHPKNIPWFVSDVTPPDFAALIAALSDPQAFYTAPDESGKTFDPLSEKEVSEVKFLFDHWSHLHAEGKLIIRPHSFWTTPGSYWRMPYVAPDLFNDLKESELVLFKGDLNYRKLTNDAAWAPTTPFTEAIGPLGPQSGVRVMAFRTCKADVVVGLPEGVDEELRQLPNGGGDEARKWAWSGKWAVVSFCDGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYP3</accession>
    <name>A0A8G1QYP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_451616</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513224.1">
        <property type="nucleotide sequence ID" value="XM_025660628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYP3"/>
    <dbReference type="GeneID" id="37164030"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF6">
        <property type="entry name" value="TRANS-ENOYL REDUCTASE APDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="15"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH55302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="360" mass="38569" checksum="1C10F33538B96C68" modified="2022-01-19" version="1">MPAIPTTQSALVVQGPNSLRCVTDTPVPSLTGDQILVQTRAVALNPSDWKMLDAAAATPGAISGSDFAGVIVACGEEVQNMSIGERVCGFVFGASPTSPNNGAFADYIVAHPSLCFRVPPTMSFEEAASVGMGLMTVGLLFRSLGLQTQISLNPDSTNTNKPFVLVYGGSTATGTLAIQMLRLHGYQPITTCSPRHFPLVKQRGATAAFDYASRTCKEDIRAYTKGTLAFAMDCIADSHATTVCYGAIGGDGGRYCALDRYSPRLEGRRQDIQPEWIHSATIFGEDVQLAGSYHRTARPEDREFAIEWARHCTHILARGDLQTHPLQVQKGGLPRIVGDLPLLRSKQISGRKLVYPVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZA3</accession>
    <name>A0A8G1QZA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_522309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512822.1">
        <property type="nucleotide sequence ID" value="XM_025665255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZA3"/>
    <dbReference type="GeneID" id="37168657"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827:SF1">
        <property type="entry name" value="HNH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="259" mass="29910" checksum="2B82C4358E00062C" modified="2022-01-19" version="1">MTAPDSENYQIFRDCVSSAIVAKFSPTPRTKKARRPRTTPRQKTSSRADPKPEAEQVQQNEFTRTDPEDLADFIDFIATETFPSLQPPTLQTLTYDPNTDFTSDKEYSPQHLAERTSHTLPASITDTLTAYAVIESASDIPYFLAPILGEYVASVTKPPPVWATTRTDACEICERDWIPLSYHHLIPRSVHAKVVKKGWHEEWRLNSVAWLCRACHSFVHRMASNEELAREWFTVERICEREDVMDWARWVGRVRWKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZF1</accession>
    <name>A0A8G1QZF1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_461671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512897.1">
        <property type="nucleotide sequence ID" value="XM_025661801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZF1"/>
    <dbReference type="GeneID" id="37165203"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="2">
        <location>
            <begin position="212"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH54975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="407" mass="45832" checksum="351837E4B8D9FA5E" modified="2022-01-19" version="1">MTQMKRPCSPTPLPSKRVSTTACLTTDALKEHDRNTRPVSLITRLDIASEQSTSGIPGEIPILSPSTRSSQRSRSSSPSRLSDAQYRYRLLRRANIFVDDEIPMDIQHETENKVFNVLFDTDDSNLYKVSEKFWHKSKELVRKLSGEAEWTEAFYTAIDELKPDGLEVARNRDWREDLKPPVYNPLSTIPRKRDRSHRIVPGYTVEPTIPIFKLKDPRPDICVGLSDENLANALVPKKGRSAARRFLVDLQETSSLISDPHVTPLGLRFPFLVVEAKAAATGGNLYQAQNQAAVGGSAALQILKNLSDLQDLDEEGQEITEDGPVVAQDLPNTKLRLAFSVTTEGPIHELWIHFQKPREEDFYMVCLGTWRTTLKDGSLNFLRQLSAILRWGSGELKDDIISVLQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZU3</accession>
    <name>A0A8G1QZU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Centromere-binding factor 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">H/ACA snoRNP protein CBF5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Small nucleolar RNP protein CBF5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_399391</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. Catalyzes pseudouridylation at position 93 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs; H/ACA-type snoRNAs probably guide pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514845.1">
        <property type="nucleotide sequence ID" value="XM_025657094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZU3"/>
    <dbReference type="GeneID" id="37160496"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="18">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="17">
        <location>
            <begin position="274"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="398"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH56923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="485" mass="54541" checksum="E10C341071A1872A" modified="2022-01-19" version="1">MAVAVAKEEMDYAIKPEASSSKIDTSEWPLLLKNYDKLLVRTGHFTPIPAGSTPLKRDLKSYINSGVINLDKPSNPSSHEVVAWMKRILRAEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKIPGGEAQFKRALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNERHLGVFWVSCEAGTYIRTLCVHLGLLLGVGAHMQELRRVRSGAMDENSGMVTLHDVLDAQWMYDNQRDESYLRKVIKPLETLLTTYKRIVVKDSAVNAVCYGAKLMVPGLLRFEAGIEVNEEVVLMTTKGEAIAIGIAQMSTVELSTCDHGVVAKVKRCIMERDLYPRRWGLGPVALEKKKLKSAGKLDKYGRANEATPAKWKNDYKDYSAPEEEGAQAVAQPVAKEEAATPAEQTETPSSPNKMDVDDDDDEKKKRKRHEGETPEERAERKRKKKEKKEKKERRKSKQEKEESDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZY0</accession>
    <name>A0A8G1QZY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosomal protein L36e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_421712</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH56983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514905.1">
        <property type="nucleotide sequence ID" value="XM_025657941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZY0"/>
    <dbReference type="GeneID" id="37161343"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF160">
        <property type="entry name" value="SAT4 FAMILY MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="42"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH56983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="400" mass="44708" checksum="91E8AE1081ACF7E8" modified="2022-01-19" version="1">MAEVYLNGNSSSPSYDYRYSHQPWNVVTQTACLVLSTGFVAMRLYSKIHITKAPGWEDCFVGISLEADRHGIGVHQWEVDPHDLSDFAKLINASQVLYGPLIFLTKLSIFLLYLRVFAPSPKCNPWWFIQILMGLNFFFYLADTIVKIFECTPRARIWDKTVPGRCIDAAIPVLVTSIVNVVSDIMMLLMPIRCVWRLQITLRKKVGITAIFAAGLFGCLASVMRLHWSVKNRNTTDNTYDAFPELLWTTAEITSGIIASSLPALPSFYRHISQKAKTLVRSISTASLTTFKRRLPSTGNGSGARQSVSHLSWHPSSDPGRSELVRSGSDWEMGEIGLFHGTFFMTTTGTTEGDGEKGFHSNIDGLRVEEEGCKQQLPRDGILKTVQVEIESGPALKEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R187</accession>
    <name>A0A8G1R187_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_421578</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515610.1">
        <property type="nucleotide sequence ID" value="XM_025657934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R187"/>
    <dbReference type="GeneID" id="37161336"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH57688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="511" mass="57367" checksum="7E8FC1422D8718B7" modified="2022-01-19" version="1">MSKTFTRAEVAQHNTEDSVWCIIDHRVYDLTDFIDAHPGGSVVLNQVAGTDATVDFYNLHRQEVLEKYKDLCIGTVAGETPEIVTPEPGSLSQVPYAEPLWLRPQFKSPYFNDSHRRLQKALREFTDRYITPEAQEKEKDGTYISQELIDRMAEAGILAMRLGPGKHLHGRKLLGGVIDGKEFDYLHDMVLSQELVRSNARGFQDGNMAGMCISLTAVQQWLRNEPLRQKITDEVLSGKKKMCLAVTEAFAGSDVAGLRTTAKKTPDGKHFIVNGTKKWITNGMFCDYFVTGCRTEKGFSVLLIPRDEGVETKQIKTSYSTAAATAFVQFENVKVPVENLLGEEDKGFIVIMSNFNHERFMMCCSVIRMCMTVVEECMKWCNQRIVFGKKLIEQPVMRQKLARMISLCESNQAWLESIAYQMCNMTYAQQSANLGGPIGLLKSHATRSAQEIADLATNIFGGRGLTQTGMGKVIEMFHRTYKFDAILGGTEEILADLGVRQAMKKFPKAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1E9</accession>
    <name>A0A8G1R1E9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_450674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513947.1">
        <property type="nucleotide sequence ID" value="XM_025660432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1E9"/>
    <dbReference type="GeneID" id="37163834"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034016407" evidence="1">
        <location>
            <begin position="18"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="63" mass="6776" checksum="9D552298CE1F8747" modified="2022-01-19" version="1">MKFSLIWSLSLLLTVHAAVIPRPAESSMSLEAGVRAAGYEASGIHERSALPHDEDNTVIGEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1F7</accession>
    <name>A0A8G1R1F7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_374493</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514426.1">
        <property type="nucleotide sequence ID" value="XM_025656133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1F7"/>
    <dbReference type="GeneID" id="37159535"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034506233" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="25"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH56504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="508" mass="55322" checksum="6195605C52CD2824" modified="2022-01-19" version="1">MGVKAFSFFVAAAQLSAVTAAASRLTVDTTVGRLYGMINGSAPDVAQFLGVPFAAPPVNELRFAPPQTKPAEAIIDTTKIGPSCPQYPLTTKTDPSVYTFDSPWLQPYGPTSEDCLTLNIWSPLHAVNETYEPLPVLIWMFGGGFYEGGLLTNGFDPTNWIQRTQSHIVVAINYRVNIFGFPNAAGLAETQQNLNFGLLDQRFAVEWVRDNIAAFGGDPSKITLWGQSSGAASTDYYNYAWPDDPIVSGLIMHSGSVFATGSSVDVEHTNFTFVAEHMGCGDLSPRAELACMRNVSADSIIQFYENYTLYSTGPTLKFTTIVDNVTKFEDYTARANAGNYSKLPAIFGTNANEEASLVAWAGPQGPNMTYVHEETVTTHLCPANYNGHLRYNTSSLSFRYFNRANFSNISPRPWEGAYHSSELPLLFGTYSEYGGPATPFETAVASHWQDLYLAFMRDPVNALPAMGWPAYHPDGYAMMFAANGTVTSLLPMGTLETPCAGIPEPTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1J9</accession>
    <name>A0A8G1R1J9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_489348</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514486.1">
        <property type="nucleotide sequence ID" value="XM_025663598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1J9"/>
    <dbReference type="GeneID" id="37167000"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF5">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034345899" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="26"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH56564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="225" mass="22412" checksum="684AF7B8F56A80BC" modified="2022-01-19" version="1">MRSVFYLALSAIASLAAASDNPFNVPEGGYTFTAGSPTTLTWDPTTNGTVTLRLQWGAVFTTTTGDLIAGSIDNSGSYSWTPSADLAARSDYTVEIIDDDNTDDVNYTPRFSVSGATGAVTTSTASSTTSSASSTSSSTDQTSTVSATTLSTTTSSASSSTSTTTAASNSTVSATSSKTASTSSSNTASSSAATASVTTVSTNAGMANQVSIGMMALVFGAVALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1L4</accession>
    <name>A0A8G1R1L4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="4">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_449566</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="4"/>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515495.1">
        <property type="nucleotide sequence ID" value="XM_025660190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1L4"/>
    <dbReference type="GeneID" id="37163592"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000013">
        <property type="entry name" value="Proteasome subunit beta type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9 15" id="KW-0647">Proteasome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH57573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="296" mass="32882" checksum="37048DFE9EB070A0" modified="2022-01-19" version="1">MDKLVAQYSRPPHQNEFYSEQEQRDLTESLPPLSLKFNLPPVDNSRAFLRAMTDDHSNPSCPIKLAHGTTTLAFRFQGGIIVATDSRATAGNWIASQTVKKVIPVSRLSRGEDKPSNEPTPGLLGTMAGGAADCQYWLRYLSQQCTLHEIRHKRRITVAAASKILANLTYAYKGMGLSMGTMLAGMTPQEGPALYYIDSDGTRLPGNLFCVGSGQTFAYGVLDANYHYDLTEEEALELGRRSILAAMHRDAYSGGFINLYHVKEEGWVHHGFNDMNPIFWKTKLEKGEFSNVTSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2T0</accession>
    <name>A0A8G1R2T0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein artemis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA cross-link repair 1C protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_519272</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516296.1">
        <property type="nucleotide sequence ID" value="XM_025665037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2T0"/>
    <dbReference type="GeneID" id="37168439"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="14">
        <location>
            <begin position="364"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="445"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="555"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="454"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="503"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="603"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="629"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH58374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="737" mass="82455" checksum="75D8DBE8DD545A27" modified="2022-01-19" version="1">MLLRIEKYPHRMNFSKGILESRKLHYKHLSKLLRPIPLNTPTELDLTPRLSIRVTLFDANHCTGAVMFLIEGNGKAILYTGDIRAEPWWVNSIIRNPVLVPYTLGIKQLDNIYIDNTFARPSHVCHTFPSKAEGLKELLNKVQGYPDSTTFYLRAWTFGYEEVWMALSAALNSKIHVDRYQMDLYRSLAARGVNDAPFLCGYELGNRFVPGCLSEDENSRIHSCEPGVHCSAAASQDTVRITPIVTRTNDGSEMPEIGAGGGGGDLYQVHELELPDQSALEQLEKLCSERIQDTSALSQTRQALIDAFRSKTKALSLDNYGMKDAHDLPLEDLVGILSRGRPDDDTTSSKMNQHTHLRDRQGKSLPKTIHFPYSRHSSYSELCHLVSAFKPKDVHPCTVDPVSWDEEVSMQTLFGHLCSASGFAHDQQMRDLTANDPEIRARKRARYEGSFTTQSSQQASSMIDSSIPEPFQPSHPPPPAAISDPLSSSDRIPLPSSLEPIEDPVPVPTDHPLIIPTPSPETAKTRRDEIRRAWHMLNNAEPSERALYQLDSLPSSLAEEESELPKSEIAPTPHPPLDNPPHTTTTAKHISSIQTQTSSSIINTNPDPQHSPTYTQPSATPPHSDDNENQTQTQTNSQSSEPLSLSSSTFESQEQETSIEQQRQQEEESIIPNYDGTADHITPHYRHRHRQQSLRRSVSAQIRRDAYLAARADSFEAWAAVSLISTGDNHTEEEIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3G4</accession>
    <name>A0A8G1R3G4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rrn9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_520527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514982.1">
        <property type="nucleotide sequence ID" value="XM_025665141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3G4"/>
    <dbReference type="GeneID" id="37168543"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019622">
        <property type="entry name" value="Rrn9_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10680">
        <property type="entry name" value="RRN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rrn9" evidence="2">
        <location>
            <begin position="150"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-domain containing protein second zinc finger" evidence="3">
        <location>
            <begin position="585"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH57060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="71832" checksum="E2465A70E190C7A0" modified="2022-01-19" version="1">MSSPSGARFSPPQSAQPYRSIFGGPSSQDVADLVPYPETQTGTGDSQQDLDVIMEEEPIENDHSDATYVESNDDEQSGSDADSYASAPQSPEKQRRLRQQKQPPQKATEYDYQRDSETPPAHSYRPNRFRGPESTWRKLTAEDRQNAQALEDIRARDLAAHLYNAYALRVRAREIARRATETNEQLLDEMDTFAPPKRWTAWPLPSAEVPRPDEEIRKSLDDAWTLRMQPDPRPSAELEESIMAFMLRTAKERFMAREWDYESKPFTSHRRKRSASQHETQDESTAWESEREGADGVPLRPTVQTDDDKSRRQLRPLTRNILSRFDDLLLGLHRARKGGVAADDSSASDWQTDTESVMSGSSPRKRKVNSQRDRSLSRGRKRTRRSSFKSGSSDARSRSAHVSSEPESSVYSSSQATSRHRSQSQHSSRSRGRSVGSDRRRSASRIRLGIRDWSEVLGVASMIGWPPAVVMRTAQRCSALFGEDMAFQVLKEGKIKQDIQDDDTKIWKYEESESEPEVETDLEPESEAEAEISQPSRSQSRRPRSRAASIKGGSTSRANSTAPEDTGDGSRPKGKGEHRKQDLICPIRACSRHGKGFSRTWNLNLHMKRMHPNYRSKSEGRSSTGTRGEDDIDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3I8</accession>
    <name>A0A8G1R3I8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_370366</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516716.1">
        <property type="nucleotide sequence ID" value="XM_025655958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3I8"/>
    <dbReference type="GeneID" id="37159360"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="57"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="478" mass="52231" checksum="EEAF5E4471E62E26" modified="2022-01-19" version="1">MSDTGSGDLQPKNGFQHLESSESGPPYQLEGAVPSSSMEPSTSRQAVDWPQWKKNAMILMVSFHSMISVFMAAGVVPATSSMAKSYGVSLADASYLVSIQIVLLGIAPIFWIVITERYGRHYILIFSVLLSMVCNIGGARCKSYASQMITRVLTAAFISPPIGIGSGVVAELSTPDEYARKVGWWVLMTILGTPAGPFIMGFVVQHIQVEFIFWIYAIINFLQAVAYICLGGETLLRVMEPENDAAEEENVSIFRKFADSSKWLLLLPKRLDARPIRISDFVSPFRLAKNPRILVAALATAITFCYANIVFVVEMPLTFGEKFHLDAQQTGLQFIPIIIGCVIGEQIGGPMSDYFMKVYRKRKGRVCPADRLWLTYPGFLTIIAGQLVWGFQLERATSWNVTPCVGIAIASFGNQIQSTILTAYAIDTSPSGSASIGVLFNVIRLLYGFTGTAGLMSGIVVLGGIIPTMIVQVTSPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3Z9</accession>
    <name>A0A8G1R3Z9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_458895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516679.1">
        <property type="nucleotide sequence ID" value="XM_025661614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3Z9"/>
    <dbReference type="GeneID" id="37165016"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF9">
        <property type="entry name" value="AMINO-ACID PERMEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH58757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="539" mass="59354" checksum="3098B37E89ACD3B1" modified="2022-01-19" version="1">MADIKAAANPAMETDGAELEKVRIAGTNQADTQLAAEFGYKPVFKREFGYLSTFSFAVSISGLFATIMTTMSYPLEAGGSSAVVWCWLVSGAGCMCIALSVAELVSAYPTSGGLYFTISRLAPHDWVPSISWVTGWLNFLGQICGVASSEYGGAQMLLAIVSMCKGMDNYEIKTTTTVGVMAALTFITGLVNSLSTYWMEKMTKFYVIFHVCVLVACAIALLVMTDDKHDASYVFTHVESTSGWQPIGFSWLFGFLSVSWTMTDYDATAHITEEISNPEIKAPWAISMAMLFTYLAGFLFNIVLCFCMGDPNAILNSKMEQPVAQIFYNSLGKGGAIFFTVSALLIIKFVTFTAMQSLGRTVFAFSRDRMLPFSNVWVKVSPMTGTPLYAVWISVFFCIAINLIALGSYTAVDAVFTLCSIALDWSYCIPVLCKLLFGQFRPGPWHMGIFSKFVNAWACLWTLFVSIIFVLPTDRPVTPDNMNYACVFLVFVLLFALVYWFISGKRFYHGPITEAVVADSASESNLPSDAKSNKDRREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R432</accession>
    <name>A0A8G1R432_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_417868</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516815.1">
        <property type="nucleotide sequence ID" value="XM_025657786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R432"/>
    <dbReference type="GeneID" id="37161188"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF6">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="15">
        <location>
            <begin position="35"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="266"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH58893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="453" mass="48974" checksum="18546DE7B7CBB67D" modified="2022-01-19" version="1">MNLQEVIRQLFSVENQYSLPEDATSRSHLVAHKFREIPRCSLNCLYPQILSTCSHTDYTCLCTNLSIIAATTDFQSCFHQCPINPDQRLTPNSLLSLCDLFNFHPDLPEYMTANANLDRRAEFINDAQTIYSIVTTIYASTQSTSSTEASSPIVTEVITTTPESSTGITTQTIFSTETDSTTSDDDTATTTSEQPNVVTVTETRLVSTMRMTSVATQTSSSNSNNAEGLSTGAKAGIGVAVPIGVAIIALLIFAWFQKRRKRKQLAGDVSNSEESGQATTVQHAEGKDNSMTQNITTVLPEIDGAPLNESDSRPVHNSADRPVFELSTGSVRRPRRDEPQVESGAVGVDGLNAKQGAVGGEVASSASATLGEAPAELSSDGVRDGESTASVVAYERMSSSELQEELARVARSRERLQYLQTLEEREDMIRRVLAGHREDNVSRAESRGEGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4E0</accession>
    <name>A0A8G1R4E0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_519195</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516209.1">
        <property type="nucleotide sequence ID" value="XM_025665027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4E0"/>
    <dbReference type="GeneID" id="37168429"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000029">
        <property type="entry name" value="Probable endonuclease lcl3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="17">
        <location>
            <begin position="80"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH58287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="276" mass="31833" checksum="09336212A17A15BA" modified="2022-01-19" version="1">MRWPPWTSNAQATNNDHPTTTDNNNDPKNLLDWSAYTELRTLIPTLFLTTGILGAVTLHRTYLRRFPTAVNITPAYYRRRSLLGKVTSVGDGDNFRIYHTPGGRLAGWGWVPWKKVPTTRKELRDQTIHVRLAGVDAPEQAHFGRPAQPFGKEAHEWLTGYLTGRRVRIYVHRQDQYQRVVATVFVRRALDFPIPFRRRDVGYEMLRKGLATVYEAKVGAEFGGEVMEKKYRSAEWWAKARGLGLWKGFKKDRDAWESPREFKTRTGMEDGGQGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4N1</accession>
    <name>A0A8G1R4N1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP citrate synthase</fullName>
            <ecNumber evidence="4">2.3.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_397915</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="4"/>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515597.1">
        <property type="nucleotide sequence ID" value="XM_025657042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4N1"/>
    <dbReference type="GeneID" id="37160444"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF10">
        <property type="entry name" value="SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="15">
        <location>
            <begin position="2"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="14">
        <location>
            <begin position="296"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH57675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="485" mass="52883" checksum="2400A54990AFE050" modified="2022-01-19" version="1">MSAKSILEADGKAILNYHLTRAPVIKPTPLPPSSTHNPPPKLASLYFPEDVAVKDVLDQAEVRYPWLLTPGSKFVAKPDQLIKRRGKSGLLALNKTWAEAREWIEARAAKDVQVETVTGVLRQFLVEPFVPHPQETEYYINIHSVREGDWILFTHEGGVDVGDVDAKAEKLLIPVNLEKYPSNEEIAAALLSKVPKGVHNVLVDFISRLYAVYVDCQFTYLEINPLVVIPNADATSADVHFLDLAAKLDQTAEFECGTKWAIARSPANLGLPTLPSSDKVNIDAGPPMEFPAPFGRELSKEEKFISEMDAKTGASLKLTVLNANGRVWTLVAGGGASVVYADAIASAGFVSELANYGEYSGAPTETQTFNYARTILDLMLRSPIHPDGKVLFIGGGIANFTNVASTFKGVIRALREVAPVLNEHKVQIWVRRAGPNYQEGLKNIKAVGEELGLNMHVYGPEMHVSGIVPLALLGKKTDIKEFGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4Q3</accession>
    <name>A0A8G1R4Q3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_275323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516374.1">
        <property type="nucleotide sequence ID" value="XM_025655138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4Q3"/>
    <dbReference type="GeneID" id="37158540"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="61"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="429" mass="46941" checksum="34CB508DEF8D83D7" modified="2022-01-19" version="1">MSHFTIHTSSLFDPKLKLLRPNVSVTVDPVSGLIVRVFERDSNTPLSELIQPGDIDLRGKYVLPGLVDAHTHIFLHSYDEAGALQQKRDESIGERMVRAVNHCRTALLAGYTTYRDLGSEGMQDFDASIRDAIARGLTPGPRLFVATKVLASTGSFECRTENSAGGHCLPSSADAVDGVEACRQAVRRRIAAGADIIKFFADYRRRIMRYPPAQQHPYIAGVLHPPKEPNPDYMVFSKEEMQTIVAEAKLARCPVSAHCATLEGAMAAIEAGVSTIEHAYSTTDEMFEEIVKKDVILVPTLAIAERLHTKRFDQILNGVKRAHEMGVRLACGGDTGTYPHGENVRELELMIQAGIPVGDVLEACTIGGWASCGGDLCGRRFGWFEEGAQADIIALRGNPVEDPGALREVDFVMKDARVWKLDGTPKGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5H7</accession>
    <name>A0A8G1R5H7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_467675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516794.1">
        <property type="nucleotide sequence ID" value="XM_025662204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5H7"/>
    <dbReference type="GeneID" id="37165606"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="222" mass="25662" checksum="7A77717EDE777A3E" modified="2022-01-19" version="1">MPPWRTPRVLLTDFTWPNNIPAVPSDQILPTPVRYYLRSFYHSYCDRVGISFNNQIAQLPFRLLLKWSDSTRIEEVLTMKVARQAGLPVPKVICYGDHLDTPHAPIPILMTGVAGKQLAIRKWKRLWGEKRICSLIGTPIQSTRVPDHRIGPFETEKEFNEYLIELGWPGVFRSKREYKEALRCREAAGWYHLILTVDGMDYMSKLEIARALTSLTSESCSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5P4</accession>
    <name>A0A8G1R5P4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_394341</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516899.1">
        <property type="nucleotide sequence ID" value="XM_025656921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5P4"/>
    <dbReference type="GeneID" id="37160323"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF2">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034842158" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH58977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="556" mass="61577" checksum="2FD11E8120F5371C" modified="2022-01-19" version="1">MFLLDLLQTILLFKVPLLSQFAPPSRAPTSGGAFECSADAIQSLLPEGSKVLYASHYDANDSFTPPLEHNSGAFRISSYVLPRSACVFQANLTLPGETEHSVGVVLPDDWNGRFLTAGNGGFSGSVSWGSIIDASWYGFAAVSTNTGHESSGAEWAYHNQEALANWGYRAMHDAVVNGKSVTEQYYGKKIAYSYYRGCSAGGKQGLKEVEMFPDDFDGVIAGAPAWWTTHLQLWNMIVGIWNSPEESLHHLSNEHIDLLAHEVIRQCDPQDGVEDNIVMNPDACIFHPEALLCADDAEDPSACLNTEQIKTVYKLHNDWVEANHTFVFPHLTLSSEWKWSGLVSSPSRLGTDYVKWMLQLGDDWRWEDWDPELIELSDGLNPGNATTDDYDLSPFYNKGGKLLHYHGWSDWSIAAGSSIYFYDQVVNALRPKGINPDDFYRFYLIPGMGHCGGTSDLMNAPWVIAGDGQSSSLGRDGNVHSVPGHEDAKHDVVLAMMNWVENGTSPDELIATKFVNDKDPEEGVYRQRPLCVYPAEAQYKGSGDINAAENWECREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R613</accession>
    <name>A0A8G1R613_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_415328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518130.1">
        <property type="nucleotide sequence ID" value="XM_025657680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R613"/>
    <dbReference type="GeneID" id="37161082"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034787824" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="866" mass="96108" checksum="BBB09360688E9BF9" modified="2022-01-19" version="1">MKLPFLVTILSATLSSAVPIANTTTICGPDEAIIILLSNNTTKTIKKADLKSQIPNLTYLPSTNNDSTPPLLITSASSHRNNTTTKRGSSTNLIIPLEPQTFLGWDIAMSTITHANQAPVTLAIQSGQSIANSITTGASADFSLIEDFLSLTTSISYQQTTTSTITGTVTMTIPKGKWGAIVSNPLTHRTRGYVFNGEPGNGGTFEYYQADSYEDSSYTYGEGKLEEKCDRQIRPPQLSLILRDNNVLQLEEQQLQDALEQSREYWYQIANLAFHLREAGFSSEFTNPRLALHRIPKLQVRSGRLHVRPYGMTHIRSLCCEASSIWTLSTDQDCGKLKKQISHLTFVQVGTAAATSFSFIEDAFSSWDGMSGGNAIGSNHLGILALGWCYVLSAQLVEMRGEDSSMQYTLCQTGYSNESLPDSSQAHVIDVGEVDASVARWWSAILAPNEGWKATVKQTPQGEFLAPWSVSRACETHFSIKYKGALSPDPDPTPLSSERAVEALVEFARLHELQSQFSIALTMALTIPTHKYYGLSAKLPLPRDTGSKPVETPVDAEWMNLKEDLPYYMTLSCSPEVMMSTFCGAFWEQDVPCNLVSPWLHPIINEVLGGLPENGLEVLAFIGTIRQPRFTTFWIGAIASGLGPEILHRVRRGHPPLDRVAFPWTGCPQSFMDVAGSGPYTCKDPNYILREDVWRLTNYPSTDGDNESYQHGPRVPWAPCGASLTRDCALYVTAHLDCPRHGYEYDHWVWYLPDGTLMQDSGFSEQVTPAVSESHFDNIQLKTRREFKRTQLDQEASREASGQVFLWYFFGGEGLPSESIYQEEWLKEIWENNMSEFGGGEFDDGEVPEPVVKSGEFVDSWLNTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R622</accession>
    <name>A0A8G1R622_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Phosphate carrier protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_447749</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transport of phosphate groups from the cytosol to the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517804.1">
        <property type="nucleotide sequence ID" value="XM_025659782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R622"/>
    <dbReference type="GeneID" id="37163184"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035434">
        <property type="term" value="P:copper ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000076">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF13">
        <property type="entry name" value="PHOSPHATE TRANSPORTER PIC2, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="113"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="214"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH59882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="307" mass="33926" checksum="778DC79E1E699CA6" modified="2022-01-19" version="1">MAAQKPKYPLGKIEPNSAKYFASCTLGGIIACGPTHTAVTPLDLVKCRRQVDPKIYTSNLSAWRTIISKEGLRGIFFGWTPTFVGYSFQGAGKYGFYEYFKYLYGDQLFPNANRTVVFLGASASAEFFADMALCPMEAIKVRMQTTLPPFAHTLREGWSKIVAQEGMSGLYKGLYPLWARQIPYTMTKFATFEETVKYIYKTLGKPKEQFNGLQQTGVSFLGGYIAGIFCAIVSHPADVMVSKLNADRKAGEGAMTAVSRIYSNIGFSGLWNGLPVRIVMLGTLTGFQWLIYDSFKVFLGLPTTGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6N8</accession>
    <name>A0A8G1R6N8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_390789</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518998.1">
        <property type="nucleotide sequence ID" value="XM_025656786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6N8"/>
    <dbReference type="GeneID" id="37160188"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="50"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH61076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="550" mass="58468" checksum="E389C7ACB25824BF" modified="2022-01-19" version="1">MERSDSISLPSIEAQQPQGQVTDKNETKDNSQNAAITASQYPSGIKSYLAVATLCLAIFLVTLDSTIIATATPYISDDFHSLGDVGWYSSVYTMVICTTQLLFGKLLARYSVRWIYSISMLFFLVGSAVCGAAPNSHSLIIGRAIAGVGCSGLLVAAFSLVPILVAPAKRPILLGLLSGSRGLATTFGPLIGGVLTEKVSWRWNFYINLPIGAVIQIAFFFLVHPPKRDHEAFTSWTEFLKTLDLFGLVALLPSIVCLLLALQWGGLKYAWQDARVVVLLVLAGILAIAFISVEIWQGPNAMLPSRVFTQRTVSAASFFGFCTVSAIFVLTYYLPIWFQGVKSATPIQSGIWTLPWVITSTIVSLAGGILMSKVGHPDIFMGIAIIFGAVGSGLFTTFTVDTPTGEWIGYQIIFAISSSLCSVTPLMVAQQALPLKDIPIGSGLVMFSQTVGASIFVAVAQALFTNELSAGLKGTAVGDGLDVSGLLSGGISTLTEGLSGEAKRAVLVVLNEALTRSWQLAVVLECVAVIGVLAVVQGMRMKRVTAVTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R766</accession>
    <name>A0A8G1R766_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_486581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516887.1">
        <property type="nucleotide sequence ID" value="XM_025663398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R766"/>
    <dbReference type="GeneID" id="37166800"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="8"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="238" mass="27895" checksum="4C6D68375D110C9E" modified="2022-01-19" version="1">MAAQKICIPELLEMILLQLDMRSLLVSAQRVCRAWHTLIKDSSSLQTLLFFKPATNAFPTEPRARDMVEDNPLLSYIWHEFWRKKASNLYFPQLDSHIEKVFLREEASWRQMLLRQPPVSLMGVFEYEKSYRAPRGSACWFKEEDKFTRLEYLYSEISRLSLIPGRDLRSFYERDLIDLYEKRLGYMRARVTSCHLPSCAFVIYCHEILGVTGEPYGHGPLNSDLELWLGNELGVYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R773</accession>
    <name>A0A8G1R773_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_446531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519298.1">
        <property type="nucleotide sequence ID" value="XM_025659526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R773"/>
    <dbReference type="GeneID" id="37162928"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034516048" evidence="1">
        <location>
            <begin position="20"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="226" mass="25811" checksum="0AC9E7779A739EF3" modified="2022-01-19" version="1">MKIVPIIFLAISTGAFVLPQNMFQPFQPSFDSINNEIDQPTTTTLPITYRKCYKLTHIDRGEIKRFIPHGGHGGFFWEPLLFDEDTPPRTFQVCGDYKSGCPSPEGNVTDGGSFYLNWLSKEWGPLVLKANRDKSWYLWPNENSENKDPLVPFKFQAVKDDGDKKGFLRIRGNNTHGFNGLVIVKEYNQNALWNTKGDGSMKFRFDEVECKGDETQHLDGEEHGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R776</accession>
    <name>A0A8G1R776_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_447973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516902.1">
        <property type="nucleotide sequence ID" value="XM_025659826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R776"/>
    <dbReference type="GeneID" id="37163228"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="14"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="208" mass="22894" checksum="BDF3D4F06DA75260" modified="2022-01-19" version="1">MASLSRVTRINNPALFICDLQEKFRHAIYEFPKVISTTTKLLRASTPLNIPIYITTQSRDKLGATVPELTSHLTSNPLVRADLDKTLFSMITPEMESLLPSPEKGEKALDVIIVGIETHICVLQTTMDLLRRGHRVYVCLDGVSSVNKEERGVAVARMRDAGAIVTTSESLLFEMLGDAGHEGFRGVSGLVREMKEETRGAVEGLAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8S4</accession>
    <name>A0A8G1R8S4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_448827</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516777.1">
        <property type="nucleotide sequence ID" value="XM_025660031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8S4"/>
    <dbReference type="GeneID" id="37163433"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17964">
        <property type="entry name" value="DEADc_MSS116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="45"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="262"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="496"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="530"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH58855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="547" mass="58867" checksum="CE041338D1ABE123" modified="2022-01-19" version="1">MQSPGTTVGTVLYETMAGKLNPKLLQALKVLGFTHMTPVQQRVLTELPDWRSDCLVQAKTGTGKTLAFLLPTLHCLLDPSMAPPRGQVATLIVTPTRELAQQIAKSCDQLTSQMAVPLKCDIAVGGTARASAFSRFMKEAPSVLVATPGRLKDYLSEPEAAIKLSNIRTLILDEADTMLESGFLADVKHIIRHIPPKSAGWQGMCFSATLPPKVRDVVSVVLKPGYSSISTIDENETPTHERVPQYHVLMPSVADSFTTLASLLQLETKTSSKIIVFGVTANMVSLFAAAFSRGLTKLSVFEIHSRLSQSARTKTTAQFKEAAAGILFASDVIGRGMDFPNVDLVIQVGLPTNGEQYVHRVGRTARAGNDGRAIILLTEAETFFLRNNRHLPIQPHPQTDAIIEGAASYAETVAEAMYTIDEEKKQRAYSSFIGFFAGSGLLKQLRLDKPGLVQMANEMAIQGMACPEPPVIDKKIVGKMGLKGIPGFNYGHGGDSVRASSFAPRGRPGGKRDASIGGPGDGSGFEKRQKSARGRGRGRRGGGQRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R949</accession>
    <name>A0A8G1R949_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_446039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518808.1">
        <property type="nucleotide sequence ID" value="XM_025659407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R949"/>
    <dbReference type="GeneID" id="37162809"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH60886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="242" mass="27034" checksum="F3FF05B58717158F" modified="2022-01-19" version="1">MEDKTIKWYQVRECLLDPKTWLLALFSLAQNIPNGGLVTFSALIVTGLGYSSLITTVLGIPTGVLATVWQILLSLLASRVPNSRCIIIAVSNLVPMACAILMWKLPRSDKHGLLASYYVFYTYWAPYVLSTSLPMANTSGHSKKLTLNAIFFIAYCVGNIIGPQVFRSTDAPSYSHGYEGLLACLVVAIVAISAYGLLCRWENQRRDREQQQQQQQQSVTVSEDAAFSDLTDKEKRSFRYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R952</accession>
    <name>A0A8G1R952_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_483892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519795.1">
        <property type="nucleotide sequence ID" value="XM_025663196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R952"/>
    <dbReference type="GeneID" id="37166598"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="64" mass="7260" checksum="1994D1828711467D" modified="2022-01-19" version="1">MDSIKKNLENAKNKGQDYYNQMMGQQQNSDASQYAQDAKNKANEGMDKTKQTAKDYMPNQAGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9E2</accession>
    <name>A0A8G1R9E2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Ferro-O2-oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BO85DRAFT_516558</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cell membrane</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
            <orientation evidence="16">Extracellular side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519930.1">
        <property type="nucleotide sequence ID" value="XM_025664853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9E2"/>
    <dbReference type="GeneID" id="37168255"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000022">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000024">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000025">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034524680" evidence="18">
        <location>
            <begin position="25"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="21">
        <location>
            <begin position="32"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="19">
        <location>
            <begin position="158"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="20">
        <location>
            <begin position="369"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RAH62008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="614" mass="68820" checksum="62741DFDAC801833" modified="2022-01-19" version="1">MAFPSRLLPWLAATIFFFIAQCQAKTVTYDWNVTWVTANPDGLADRQVVGINNEWPLPIIEVDKGDRIVVNMHNGLGDKSASIHFHGMYQTNTTEMDGPSMLTQCPVPPGSSITYNFTVNQNGTYWYHCHTDYCYPDGYRQALIVHDNSSYFADKYDEDLTITMTDWYHELTETIAPTFITVENPTGAEPIPDSFLFNDTLNSKIPVEAGKTYLFRFINIGAFVAQYIYIEDHTMRIVEVDGIYTDEAEADILYISAAQRYTVLVTMKNSTEKNYPIVMVADSQLLDTIPSDLQLNQTNWLEYNSSAPFEQAVMTVSDCSDLNPYDDMALVPHDRMPLLENPDVSLDLTVTMQNLDDGADYAFLNDISYTAPKVPALYTVMSAGDQATDATVYGDYTHSVVLERDQIVEIILNNGDTGTHPFHLHGHAFQMIDRYPPYGPHFYDYADGDPITYNASNHTAFPEYPPRRDTFVLPPQGYFVVRFKADNPGVWFFHCHIDWHLAQGLAMVFIEAPLAIQSSVTIPQQHYEVCEAAGIATAGNAAGNTEDYTDLTGQNKQVAWLPGGFTARGIVALVFSCVSAFLGMGMIAFYGLSDIKKGGGQVQNRREEVREHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA15</accession>
    <name>A0A8G1RA15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="7">PME-1</shortName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_445459</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519965.1">
        <property type="nucleotide sequence ID" value="XM_025659268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA15"/>
    <dbReference type="GeneID" id="37162670"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000186">
        <property type="entry name" value="Protein phosphatase methylesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="10">
        <location>
            <begin position="110"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR022950-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH62043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="419" mass="45512" checksum="8113B4C176276CD0" modified="2022-01-19" version="1">MSELQKSFAKSRLAKLPLQPPTGPSMQPLDEEVSHDDDSSSTSSTGTIVPSPSRQLFARPGRGSVQQTTLPWTDYFTQELYLTQIDTPNNTKITHHVYLTPPADSSSPLFVMHHGAGSSGLSFAACAGEIRKIIPKAGILSIDARDHGSTAVTHASDEDGGEGIELDLSLETLNRDLVFVVRETQSRMGWESLPDLVLVGHSLGGAVITDVARQGELGSKVLAYAVLDVVEGSAMDALQSMETYLMTRPSRFPSITSGIEWHTRSRTIRNKTSARVSVPSLLYEDPNSPDPSKPWIWRTNLSATKPFWENWFVGLSRKFLDARGGKLLLLAGTDRLDKELMIGQMQGKYQLQVLPEAGHFIQEDQPAKTAQILVDFYKRNDRSALVLPPKVADLQASAAMKKGGGSGAGASAGGLFKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA36</accession>
    <name>A0A8G1RA36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_518159</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518567.1">
        <property type="nucleotide sequence ID" value="XM_025664953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA36"/>
    <dbReference type="GeneID" id="37168355"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="13">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="242"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH60645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="690" mass="77092" checksum="F7DF322959FEB107" modified="2022-01-19" version="1">MPIPHPFDPLSPKEIAKAADIVRHAFPGRPPNFRVITLKEPPKADMIPFLEQVHKGIGAPKRPARVARVQVVLPGGSSANEFIELLVDLEDSTILEKEHLIGRHPYIDSDYMKAAEKACMSHPNVQEEIARLQLPDGATVVVESWAYATDGTKDTSQRTTMCWFYMRLVDDADANYYAYPLDLCAEVSEDLKVTKTYQLPSGPDDRIYDKPKPFDRRKIHGAEIEYSPGLRASPRTTTKPYQVVQPEGPSFKTQGNHLDWEKWSMHIGFNYREGLTLHDIRYDGRSLFYRLSLAEMFVPYGDPRAPYPRKGAFDLGNDGAGINANNLRLGCDCLGHIKYFDGWHTTTAGDPLKLPNVVCCHEEDDGILWKHTNYRTRNAVVTRSRILVLQTIITVSNYEYIFAFQFGQDASIHYEVRATGILSTAPIDIGDKVPWGTIVAPGVLAPYHQHLFSLRMDPAIDGHSNSLQVEESHAMPVDVHSFDHTGKSQEAIDSHRNPFGVGYVTRSSIVEEESGLDLDITKNRTFKIINENVINPVTGTPVGFKLLPAYSQMLLAHPDSYHARRSEFGQHAVWVTRYTGEEHFPSGRHTMQSLGGDGIASAIAKRAGTEHSSVRNKDIVIWHTFGSTHNPRIEDWPVMPSDKMVVGLKPVNFFTGNPGLDVAISTQEKNRSVLVEGGDDVDSRSGCCNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA81</accession>
    <name>A0A8G1RA81_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_137146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520395.1">
        <property type="nucleotide sequence ID" value="XM_025654043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA81"/>
    <dbReference type="GeneID" id="37157445"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="53" mass="5918" checksum="8E585FAF22F6CAFF" modified="2022-01-19" version="1">MPLPYLRCLSAVQCLESGYIAASTDSDRSKMTCLTNEAKDILVFAFEKHAKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA86</accession>
    <name>A0A8G1RA86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_386701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520858.1">
        <property type="nucleotide sequence ID" value="XM_025656641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA86"/>
    <dbReference type="GeneID" id="37160043"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF12">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH62936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="269" mass="28614" checksum="975021CB974F1362" modified="2022-01-19" version="1">MTQTWTFPGVAVVTGAGGTGIGAATAKAFASAGCERIAITDLNSASLDQTREAILASYPQTRLLVKAGDISDESFVESFISEVVAAFERLNYAVNCAGILGDAMRTTETSTAVFDHINNINYRGAWFCSRAELRQMVAQDPLPSHDPNRAPQRGAIVNVASQLGIVGRPSAPAYCSSKAAVIAMTRSDAIDYSADGIRVNCVCPGVIETPMTTYSEEIREHFQPAVEIAPMKRMGKPEEVADSILFLCSTLASFVQGHALVVDGGYIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAE1</accession>
    <name>A0A8G1RAE1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_454687</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520485.1">
        <property type="nucleotide sequence ID" value="XM_025661341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAE1"/>
    <dbReference type="GeneID" id="37164743"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06105">
        <property type="entry name" value="ScCit1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH62563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="474" mass="52012" checksum="E9AC4019BA2B2968" modified="2022-01-19" version="1">MASTLRLGTSALRSSSIAAKPVVQSAAFNGLRCYSTGKAKSLKETFAEKLPAELEKVKKLRKEHGSKVIGEVTLDQAYGGARGVKCLVWEGSVLDSEEGIRFRGRTIPECQELLPKAPGGQEPLPEGLFWLLLTGEIPTEQQVRDLSAEWAARSDLPKFIEELIDRCPSTLHPMSQFSLAVTALEHESAFAKAYAKGINKKDYWNYTFEDSMDLIAKLPTIAAKIYRNVFKDGKVAPIQKDKDYSYNLANQLGYGDNNDFVELMRLYLTIHSDHEGGNVSAHTTHLVGSALSSPMLSLAAGLNGLAGPLHGLANQEVLNWLTKMKAAIGNDLSDEAIKNYLWSTLNAGQVVPGYGHAVLRKTDPRYVSQREFALRKLPDDPMFKLVSQVYKIAPGVLTEHGKTKNPYPNVDAHSGVLLQYYGLTEANYYTVLFGVSRALGVLPQLIIDRALGAPIERPKSYSTEAFAKLVGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAL6</accession>
    <name>A0A8G1RAL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_446082</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518852.1">
        <property type="nucleotide sequence ID" value="XM_025659419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAL6"/>
    <dbReference type="GeneID" id="37162821"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000052">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="11"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH60930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="365" mass="40809" checksum="A583224BBF34C3EA" modified="2022-01-19" version="1">MAEKEVPLTAVKVEALVVMKIIKHGSQAFPTTATGSIVGMDVDGTLEITNCFPFPVVEVPAESHFDNAAPNPAAAAPRAKANAAYEAEMIRMMREVNVDANNVGWYTSANMGNFVNMNVIENQFFYQKDMNERTVALVHDVSRSAQGSLSLRAFRLSPKFMAAFKENKFTSEELQKSNLRYQDILVELPVEIHNSHLITSFIHQLQTPVQATPSDLPPSLAALESSQYAKSSVLAPNFDNLSLSIDPFLEKNCDLLLDSIEVHHTETNNFQYYQRSLAREQAKITAWQNKRKTENASRAALKQPLLPEDEWQRLFKLPQEPSRLDSMLNSRQVEQYARQVDSFVSATTGKMFAVKGNLLPGETAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAN6</accession>
    <name>A0A8G1RAN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA a64-2'-o-ribosylphosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_444997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519479.1">
        <property type="nucleotide sequence ID" value="XM_025659161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAN6"/>
    <dbReference type="GeneID" id="37162563"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043399">
        <property type="term" value="F:tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019988">
        <property type="term" value="P:charged-tRNA amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007306">
        <property type="entry name" value="Rit1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033421">
        <property type="entry name" value="Rit1_DUSP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033449">
        <property type="entry name" value="Rit1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811:SF0">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04179">
        <property type="entry name" value="Init_tRNA_PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17184">
        <property type="entry name" value="Rit1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007747">
        <property type="entry name" value="Ribosyl_Ptfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rit1 N-terminal" evidence="2">
        <location>
            <begin position="34"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Rit1 DUSP-like" evidence="1">
        <location>
            <begin position="344"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="460" mass="51094" checksum="5E87CDB06EF3136B" modified="2022-01-19" version="1">MGSASGSDPYPVSISSLHFPSAEQQSISQTLSALRRSALSVTNRLRSIEADAAFVREVAAHYDLPLIANERCGSWYIPPEVKSGSAYFKSTDGHTGQWDFSFRRLNLQLLPIAREHGGCIIVDSTRRGKLMPDALSKTVPIWCAVINRALFPSDTAYHAVNFPPNYLGASEESQIERRIDGFVKSLVDLKLDMDELKQQLGKPIRVAWANRAYFHPTDLHKGDDYRLFVLCSASKRVHGAEMSEGGYIQGAGDDSESWAYGLTPPVFWATKATLFQHSEEDLPTVIEQLVEDHSKKNVDQRAIRIAPTRNLYLSQTHPQLNNGSMFDLVIDCNASAEGAEENANRLNLGCGSSKLGSRGLRKHLDKVQDFVKSRMSADPSRSLLVTCETGKDLSVGALLAILCLFYNEEGEFTAVPTNQLIGKQFIRQRLAWITSSKHDVNPSRSTLQSINAFLMQRPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAS5</accession>
    <name>A0A8G1RAS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycogen synthase kinase mutation revertant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_435047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520370.1">
        <property type="nucleotide sequence ID" value="XM_025658499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAS5"/>
    <dbReference type="GeneID" id="37161901"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF108">
        <property type="entry name" value="DAGKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="106"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="414" mass="45037" checksum="18E06BA4858E0052" modified="2022-01-19" version="1">MSSSVVYTVDVECSNDSGAHKDNIRCISQHDQNELIIACDSIISIVPPKKDGDKLYRLLFFRDDDDTCDHESKHTLLESIQLATLPPQLQKHLFTELPPYLRSSGPEGAKIDIIVSTTSGTGTGASFCSNILRPLLSYIGVADYELHETKSTQTITDLCYEKFIPRAKQRLPQTIILLSGDGGLTDIIDAFHSTLESLLVPPTIALIPTGTGNAMANSIGLLTYPTASLVALLQGTPTGVPTFVAELSPGARYIIDEGRERVPITRNSASFQGTPKVYGGVVASWGLHAALVADSDTVQYRKFGADRFKLAAKELLYPSDSAEPHKFSGKVTLFKLDDQSRSTREELLACTEHMPLDGRLWMVHFEPMSSSKVMQVMASAYQAGQHVEDESVSYVAEVKPGVATAIAPGSVTFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAU1</accession>
    <name>A0A8G1RAU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_445725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520234.1">
        <property type="nucleotide sequence ID" value="XM_025659340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAU1"/>
    <dbReference type="GeneID" id="37162742"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034446584" evidence="1">
        <location>
            <begin position="22"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="99" mass="10638" checksum="2E2D1CE32ADB5EA2" modified="2022-01-19" version="1">MQFSKSIVATALALFASSAVASTVDIAYTSNGAYYNQQVEPYQRTPLTQPGSISTFQNTANCYLFNYYGQEVYYVAAGATNIDPPVNAASVQCQDPSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBG3</accession>
    <name>A0A8G1RBG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_501081</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519586.1">
        <property type="nucleotide sequence ID" value="XM_025664153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBG3"/>
    <dbReference type="GeneID" id="37167555"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="76"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH61664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="525" mass="58563" checksum="EA009E999B32229F" modified="2022-01-19" version="1">MSLDIPCIVFVRSFLHRPDNPDHTENHVRQETPKQIDGHTHRRKHSTDSEKTLTVEDWATSRENPHNWPLAKRVITSLVVYIYTFVVYSGSSMFITAVPLVMHELHLSEQRAMLGLSIYVLGYGVGPLLWGPLSEIPRIGRSVVYFGTFVAFILVTIGAAEVSNYSAFVFLRFMQGLFGSPCLANGGASMHDLYPESQFPYALALWVAAAYCGPALGPLLTNSLVNNISWKWTMWLLACMSGPVCILLFLLPETYAPTIRYRSSAFNTSNNQNNNNTSSESDNPLAKLKFYLVKPVQITLQDPAILFANIYTSFIYGTYYTFFDAFPIGYPPVYNVSTTTLSLFYLSVLVGCLLAVAAYFIYLSLPNYLRKHHNHTSPKSTPTPTPPTKHERHLIPAIPATFLVPISLFLYGWTLRPSIHWIVSIIGVTMYASAVFIILQCLSMYIPSIYPEYAASLFAANDFCRSTLAAGAVHFGIPLYKNLGMARGSSVLGGVSGLGVLGLLGFYYFGERLRAKSRFVERLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC28</accession>
    <name>A0A8G1RC28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ras-related protein RSR1</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_482780</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520834.1">
        <property type="nucleotide sequence ID" value="XM_025663124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC28"/>
    <dbReference type="GeneID" id="37166526"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000114">
        <property type="term" value="P:regulation of establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04177">
        <property type="entry name" value="RSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000631">
        <property type="entry name" value="Ras small monomeric GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041841">
        <property type="entry name" value="Rsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="175"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH62912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="211" mass="24215" checksum="24D585DC5CB070CA" modified="2022-01-19" version="1">MRPQREYHIVVLGAGGVGKSCLTAQFVQNVWIESYDPTIEDSYRKQIDVDGRQCILEILDTAGTEQFTAMRELYMKQGQGFLLVFSITSMSSLNELSELREQIIRIKEDEKVPIVIVGNKSDLEEDRAVPRARAFALSQTWGNAPYYETSARRRANVNEVFIDLCRQIIRKDLQGNSKGSDSDRKREGGNRQDRRKDKKRQTRRKGPCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCD7</accession>
    <name>A0A8G1RCD7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_473317</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520518.1">
        <property type="nucleotide sequence ID" value="XM_025662617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCD7"/>
    <dbReference type="GeneID" id="37166019"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000001">
        <property type="entry name" value="Signal recognition particle GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH62596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="534" mass="57003" checksum="B230BA5B4714CC96" modified="2022-01-19" version="1">MVLQDLGRRINAAVNDLTRSNNLDEKAFDDMIKEICAALLSADVNVRLVQSLRKSIKSSVNFASLPAAVNKKRLIQKAVFDELVSLVDPHAEPFRPKKGRSNVIMFVGLQGAGKTTTCTKLARHYQMRGFKTALVCADTFRAGAFDQLKQNATKAKIPYYGSLTQTDPAIVAAEGVAKFKKERFEIIIVDTSGRHKQEEELFTEMTQIQTAVTPDQTILVLDSTIGQAAEAQSSAFKATADFGAIIITKTDGHAAGGGAISAVAATHTPIIYLGTGEHLMDLERFEPKAFIQKLLGMGDMAGLVEHVQAVTKDSASAKETYKHISEGIYTLRDFRENITSIMKMGPLSKLSGMIPGLSNLTAGLDDEDGSMKLRRMIYIFDSMTAAELDGDGKNFVEQPSRMVRIACGSGTTVREVEDLLSQHRMMAGMAKRVGGQKKQMQRAQNMLKGGNKEQQLAAMQKRMAAMGGAGGGGFPGMPGMGDMAKMMQMLQGQGGGGGGGLPGLGGMDLQSMMSQMSGLMGGGGGGGGGRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD06</accession>
    <name>A0A8G1RD06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="5">HMG-CoA synthase</shortName>
            <ecNumber evidence="5">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_410293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="5"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520833.1">
        <property type="nucleotide sequence ID" value="XM_025657474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD06"/>
    <dbReference type="GeneID" id="37160876"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="7">
        <location>
            <begin position="179"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH62911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="451" mass="49788" checksum="A0F6E3C844FEC24F" modified="2022-01-19" version="1">MASYPENVGIKAMEIHVPAQCLDQTLFEQYQGVSAGKYTIGLGLQCMNYCTDREDVCSLALTAVSSLLKKYSIDPNSIGRLEVGTESLIDKAKSIKSVLTTLFEPSGNTSIEGIDTIHACYGGTNALFNAINWVESRSWDGRDAIVVASDIALYKESSSRPTGGAGCVAMLVGPNALLSLDHSVRGVYMTHTYDFYKPDLRAEFPLVNGHESITCYIRAVDGCHKDLLRRRSMNNKNVENVLDLFDYMAFHTPNCKLVSKSYGRLKYNDLQHQSSSKPDTDLTDIPPELRTLTYEESLKDKNLEKALVALTKNQFKERVEPCITAPSLCGNMYTGSLYCSLISLISNLDLASAQGKTIGMFSYGSGLASTLFALKVTGDLAPMVEKIDLMNRLKQRHVATPEEYEEACALRLKAYGSNNYTPSGDIASLAPGTYYLERIDEVYRRTYAIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDB3</accession>
    <name>A0A8G1RDB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_444812</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Lipid-anchor</topology>
            <topology evidence="1 12">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521509.1">
        <property type="nucleotide sequence ID" value="XM_025659118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDB3"/>
    <dbReference type="GeneID" id="37162520"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000005">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF11">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034656900" description="1,3-beta-glucanosyltransferase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="14">
        <location>
            <begin position="380"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH63587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="537" mass="57260" checksum="B1A3F1900FF49078" modified="2022-01-19" version="1">MKFSATTLAGASLLLGRAIAADLPAIEAKSNKFFYSNNGTQFFIRGVAYQQDYTSNGTDSSNADYTDPLADASTCKRDIPYLQQLRTNVIRTYAVDPTKDHTECMQALQDAGIYLITDLSAPSTSINRDDPQWNTDLYSRYTSVVDAFANYTNVIGFFAGNEVANSQNNTNSIAYVKAAVRDMKAYIKAKNYRTSLGVGYATDDDSTIRDDLKSYLVCGDSDDRIDFFGYNIYEWCGDSSFKTSGYSARTEEFKDYPVPAFFSEYGCNSPSPRTFTDVPVLFGDQMNDVWSGGIVYMYFQEDNDYGLVSVDGSSVSTLKDFSNLSSQMQKVTATGVNSNSWSASNTATPTCPSVGTAWEATNTLPPSPNEDLCSCMEASLSCVVKDSVKESKYGDLFDYICAKGDYCDGMSSNSTTGNYGAYSVCSTKQQLSFVMNQYYEKQSAKASACDFSGDGTTTSSSAATGTCSSLLKEAGTAGTGSVTSSPTGGGSVASASSSTSEGAGAGLTAPNAVQVGSWQLGAYAVTAVGAALGMILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDJ9</accession>
    <name>A0A8G1RDJ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_444542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521163.1">
        <property type="nucleotide sequence ID" value="XM_025659034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDJ9"/>
    <dbReference type="GeneID" id="37162436"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039970">
        <property type="entry name" value="TF_Grauzone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225:SF2">
        <property type="entry name" value="AT09679P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="336" mass="38118" checksum="065E0E7A46C572AC" modified="2022-01-19" version="1">MSPPYTCDEVALPPLGFGSCSSPSALTDVDSLVAPSQVYPDPDPIVKLETDSEHFMGGIFRYNSPPHHDEFDTACDIKSCQYAETTSQQEACSSSSNQFKTPKLSSRNTGRISKKRPRKTSTKARSTSAARASTKTSGKKGGAKTSRVFICSFSHYGCQSTFVSKNEWKRHVTSQHIQPGFYRCDVGRCSLDNLSKNKGQDANNSCASFNETHLVNDFNRKDLFTQHQRRMHAPWVGRNSKKPETEKERDDFEQTLEAVRARCWHEQRKPPTQSACGFCGQHFLEWNDRMEHVGRHYEKGDAQYEAKDTFLRQWAIEEDIIRQVDGQWKLVGLCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDU3</accession>
    <name>A0A8G1RDU3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pyruvate carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_483110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521174.1">
        <property type="nucleotide sequence ID" value="XM_025663135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDU3"/>
    <dbReference type="GeneID" id="37166537"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45007">
        <property type="entry name" value="CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45007:SF1">
        <property type="entry name" value="CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="6"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="124"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="566"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH63252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="650" mass="70284" checksum="56DD061BD12837C5" modified="2022-01-19" version="1">MTSSKPFRRLLVANRGEIAVRIIQAARELSPSIEVYAIYTEDDTSHCECAHPDQALLIPSVSTYLDIPYLVHLAQEHAIDAIHPGYGFLSESADFAARLQDAGITVIGPGSSVLSRTGDKLQAKQLAVECDVPVLPAMAQPTADVAEVRVFAKQVQYPVMVKAVDGGGGRGIRLVYGDEGLEGAVRGAVNDSPSGTVFVEKAAVKGFRHVEVQIVGDGREVRHLWERDCSVQRRFQKVVEIAPSVIGDRGLVKRVVDAAVRMGRAIRYRSLGTVEFLVNEGSGEFYFLEINPRLQVEHTVTEEVMGVDLVLAQLKLAMGCTLAEVGLGGGGFDTPKACSIQLRLCAEDPSNQFALSVGKVTELVVPSGRGVRVDTHVRAAGASPVVVGAQLDNLLAKIIVTASTWEAAVLKARRVLADTTVAGVRTNLELLRGVIAQEDFLSGRIDTQWLESSLDQVLQQGAIVSRSVRTQAPGQGQRPSALPSVPSSNLLFRRGDAWSISLTPVEASEKSQQHHLQLTRVLRNDFPTSLAAEIEYQTPNSSSAYRLELAATSTTASALFSSAHRRGDMSNPRHIVLPLSGKLIEVLVSAGDHVAENQVIAFIKQMKMEVEVRSPRAGQAQWVYEMEDEEEDVAEGMLLVELTDGLQGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RHV5</accession>
    <name>A0A8G1RHV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_455583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521532.1">
        <property type="nucleotide sequence ID" value="XM_025661394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RHV5"/>
    <dbReference type="GeneID" id="37164796"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000557">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="384"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="431"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="680" mass="76960" checksum="000866BDD16A3812" modified="2022-01-19" version="1">MSTSPPPPPPPSGSPPAQPGSPPSRDSGTVWHPAREWLEEDEDEDDMDYEPDEIEAEEEELDAELYEDEEDIDDADDHRFGNIHIEFAMDESDHEQQGEERHEGRHNRVSAARLLNLLASNGLRHILHYNGLHDANVVEDDEEEDYEFGFFGYRRRARRSGGQQFPKVPSEEGAQLMGSGDFGSNPHYVDKLKRRKQALATKIMWRELGVDVSGPQRRDMQSITQGLIPGSVADKIVHFDSRCYSGQFSDDGNFFFCCAQDFKVRMYDTSNPFEWKYYKTVDYPFGQWTITDASLSPDNKFLAYSSIRNLVCLAPTDPADSSDPAILDLSSLSGRRGGRGLYGNSHFGIWSIRFSGDGREIVAGTSDQSVIVYDLETRQSVLRLQNHEDDVNAVCFGDKSSPHILYSGSDDTTLRVWDRRSMGDGREAGVFMGHTEGLTYVDSKGDGRYVLSNGKDQSMKLWDLRKMMTTAKFDTIDVNRYTTGFDYRFEPYPDDYYEPHPHDCSVVTFRGHRVLKTLIRCHFSPPGSTNSRYVYTGSEDGKVYVYNLDATLAGTIDVGQATANSRPRDPDIFTAAYEIRSSRSDVMWKTCVRDASWHPNSPVLAATSWNGWGLSTGTCTLHTWNDGVDSDEGDPPVAGNYDSRLNSVREFNLFREKMMQSRSRPVQRSALDDELHYELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RHX2</accession>
    <name>A0A8G1RHX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mismatched base pair and cruciform DNA recognition protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_27359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521562.1">
        <property type="nucleotide sequence ID" value="XM_025655120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RHX2"/>
    <dbReference type="GeneID" id="37158522"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="Hypothetical protein YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="19429" checksum="927149FD939ABEFE" modified="2022-01-19" version="1">MSSTDSPNNNNTTTTSTLKSYVDQATGMVQRAAGSLTGDSSTQSAGSATQSRGEAEHNASHNNFTKLGPVTADPATGAAATDHPQRSNGSWDQTVGSAKESLGNLIGNEGLRKAGQEQNAAGKQAEAEGQVRDWKEGVEGRAKGAVGKVAAAATGDEEEERKWRDVHDEGKVRERGVESEVQKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VFW3</accession>
    <name>A0A8G1VFW3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Terpenoid cyclases/Protein prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_433048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825096">
        <property type="protein sequence ID" value="RAH51679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509601.1">
        <property type="nucleotide sequence ID" value="XM_025658403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VFW3"/>
    <dbReference type="GeneID" id="37161805"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016102">
        <property type="term" value="P:diterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739:SF25">
        <property type="entry name" value="(E,E)-GERANYLLINALOOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739">
        <property type="entry name" value="ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH51679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="958" mass="107830" checksum="670C92D481265B63" modified="2022-01-19" version="1">MPPKIPQKSEQQVQVSYQQEAATLLQYLRKDQHPDYGLGAVSGSIYDTAWVSMVKKPVTGRETAWAFNECFKFLSEAQCEDGGWDADAVLFDRIACTLAGLLALKKHLNEEKDHTGRQALEKKISRATHFLRQALPKLPAAVTYELPIGAELWLPKMLELIEEESIHLDNGSVLAWILPARDKRISRFPIESLYDKGFTSVAHSLEGLIGYADFNQVSTFKSCGSMMGSPSATAAYLIYSENWDADAEAYIRRALNSPYAGQNGGVPSTYPTTAFESSWIAVTLLKSMVPLGKETEPLVKNIGLQLKNMLKAQNGLVGFAPGMCVDADDTAKALLLLRLLGLPACPDSLISTFESHDHFLTFGIERNPSVSTNAHVLMALLHMENNSTYISQIEKCVRFLCHAWWESDGFLQDKWNISPYYPVMLICEGIVDYMNKWDSGDFATSSSTGLDARVPLVVHQALTKLLQTQNADGSWGPRSSLEETSYATLAIKRLLTLPFRGELRDVSLTAIEQAELYLRYTYSRGYISIRERLWIDKTLYSIETVSRSYIISATLAPTPNIQASETLRGLFNTPRSVIQKQGNFLRSLPSFSHIPSWVLEASVREGYMIIDELRKIDFFSQRAKLSEEYLLYCASCFVASNYKGSYFLSTGYLLMVLRITVATYQLDTFVDHQVINFSSLELDELEDFIQKKLHTGRCLSTGPDATHELNECNGEPHARVKEAKAMFLCFMNFVLTDTTDPVSTYNKWSLRSELRSALLAQIGHIRSSKGLVHEGVDLLHDQTGKTTFFSWLRGPASDNVLYPVILKYMVSHMALSQVQQDDDVFRTPEEQYIVEDFCRHAAAEVRLWNDYGSIERDKAEGVLNSIDVLNLSSPRHSANGITGDTLNRHCKVESLKQIAQYESRHVRLCLEQLETLLQKNDAQRASYIMSRLHMHATVAQVWAEMYSLRRFSAASLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGE9</accession>
    <name>A0A8G1VGE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_463998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510156.1">
        <property type="nucleotide sequence ID" value="XM_025661960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGE9"/>
    <dbReference type="GeneID" id="37165362"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="68" mass="7603" checksum="C3AFD70AC31BEF83" modified="2022-01-19" version="1">MSFWSSYRSLSPKTRALFGTGVTAWASIGLWASPQVENAMGMAPTKEEQEELDRKLAVRISRVEKDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGP6</accession>
    <name>A0A8G1VGP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">eIF-2-alpha kinase activator GCN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_454494</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GCN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825092">
        <property type="protein sequence ID" value="RAH51830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509752.1">
        <property type="nucleotide sequence ID" value="XM_025661297.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37164699"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904688">
        <property type="term" value="P:regulation of cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000090">
        <property type="entry name" value="eIF-2-alpha kinase activator GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:002031">
        <property type="entry name" value="Translational activator, putative (AFU_orthologue AFUA_2G07960)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022716">
        <property type="entry name" value="Gcn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056809">
        <property type="entry name" value="HEAT_GCN1_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12074">
        <property type="entry name" value="Gcn1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25801">
        <property type="entry name" value="HEAT_GCN1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24916">
        <property type="entry name" value="HEAT_GCN1_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="1344"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="6">
        <location>
            <begin position="1521"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="6">
        <location>
            <begin position="1981"/>
            <end position="2018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2633"/>
            <end position="2653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH51830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2675" mass="291185" checksum="4CFC807AC475DBE1" modified="2022-01-19" version="1">MDDFPWDQVESGDLGSLQVVLFSSSTARRIRALQDLRDRIGTSLQPQTYQPLIGLLFKTYPRYVDRPSRQAVQQCLRSLLKAPVPTDDLKYLTQKLQVEAAKPGLAPGPALVLLEWCSVVLQILGGDSETPLSAVLDTIAVDAKALDICLASNPRPAVKASALRVTRRALRAAFSSTAWGEDAVRESVRRLTSDSTTGQRNAPFLGVISGVCARLPAKKPVLEGEKKAIISFYVKELAGAKSAPPAHIADALGDFFVSFLSYDDLATELIPPFEKAMLRSPEVVFNGLLPSLCASLPEEIDMSELLHSRLLKHLLSSMKSNNPAIRQGAVRSFESLLAKSKDQTLLTKITSEVVSPLKTQKITNPEQRAVYAQAVAAILPSADLSKDVVQGFVPVFNRESNEAALEQEIKSFCKHLAFLVQSQVKVSDDVINAIVKGSSDKRVPFKKLWQLNVGEVMWQVEPATLASTDVEPLVNKFLGKMKELYNEVAANPLPSAQGGSLSTAYVYLALLDRSSSLRSFDKSAWEETVAQSMVLNPKPSFLLNPKAYSKLTTQTEIQWAVRALAAVTTGSKFGKAEDAAKTAWAQAFIYNIAAPGLHTSFRDGAARTLSEIHLKDVAGMGRTVTSALWSWILSFRTGEKESASVSAGPESERFLHLVVKALCPPASSVQEVDNVTASLKDQLVELLVLCRPELIPSASWIASCLRTGIDPGNLVREFPEKCLEQLTRLHEDPVQSKIPQIDAAIWSAAGELAFVAPDAMVPRLVGQIQDDLDTSRLSKFTATDVAIARTPEGTMFVDVLSTKSKQSNFDKNTKDYDILKWEEELRSQLADKKGQKQKKLTPEEQSKVKAQLAKESKIREEVLQVIKKIERGCGIIQGLADGPAIDADGWINPAVSSLLSLTEAGAGLYAGDVVSKAYVKCAEKLSSRLGPLRPFVGIATLRAIGKSYLPPQMEAEALGQLVTRILYRLRFASEQRPFESTSLAYVLPLLFLVLSKNGIDEQRGDEEGEQVLLALEVLSFHSGSFVDERLPRVEVLKILLASMQKYTQHYKLIKDTLFDVCRCISPNITKDELDILLKGTIVTDVSVRTSVLQVIEAEIDLTDLDFSEHIWLECHDHVEENAEIAENIWEENALEVDDSSYEKIIPYLSSKDVQLRGAAARALAHAIAVNPSVFDRIFSELQSKYTIEIQPKVPEKDSYGMPKKMDVTDHWELRSGIALAFGAMTDLFEGEQIVSFLRFLIERGPLIDKSSAVRAQMAESGRSVIAARGQQKVEELMKLLETTLETSDKGSETSDLLNEAVVVLYGSLAQHLKADDPRLQTVIKRLLDTLPTPSESVQSAVSGCLPPLIRLSRPQSGEYVQEMLDQLLQSKKYATQRGAAYGLAGIVSGRGIVTLREFQVMSHLRDATENKKEPHQRQGALLAYELFAAILGRTFEPYVIQIVPQLLAGFGDVNPDVRAACLDAAKACFSNLSSYGVKQILPTLLDGLDDTQWRSQKGACDLLGAMAYLDPQQLAASLPDIIPPLTVVLNDTHKEVRNAANRSLQRFGEVISNPEVKSLVNVLLKALSDPTKYTDEALDALIKVSFVHYLDAPSLALVVRILERGLGDRSNTKRKSAQIIGSLAHLTERKDLTAHLPIIVSGLQLAIVDPVPTTRATASKALGSLIEKLGEDALPDLIPNLMSTLKSDTGAGDRLGSAQALSEVLAGLGTTRLEETLPTILQNVSSSKASVREGFMTLFIFLPACFGNSFAAYLSKIIPPILAGLADDVESIRETSLKAGRLLVKNFSSKAIDLLLPELERGLADDSYRIRLSSVELVGDLLFSLTGITAKADAEEEEEEAAQAGQSLLEVLGEERRDKVLSALFICRCDTSGMVKSAAMAVWKSLVASPKTLKDMVPTLSQLIIRRLGSSNMEHKVIASNALGDLIKKAGESVLSALLPSLEEGLQTSPDVDVKQGICIALRELITSASAEALEDYEKVLISTVRVALVDNDEDVREAAAEAFDALQQILGKKAVDQVLPHLLLLLRNNEDAEQALSALLTLLTEQTRANIILPNLIPTLLTSPISTFNAKALASLAEVAGSAMTRKLPTILNSLMDEIVSTKDEAHREELSNAFDTILVSVDEYDGLNVMMNVMITLMKHDDHRRRATAAIHLDKFFSNAEIDYSRYHQDLIRVLLISFDDSDKDVVKAAWTALNGLTKHLRKEEMEVLTISTRQTLRSVGVPGANLPGFSLPKGITAILPIFLQGLLNGSVEQRTQAALAIGDIIDRTGADSLKLFVTQITGPLIRVVSERSVDIKCAIFFTLNKLLEKIPLAVKPFLPQLQRTFARGLADASSETLRNRAAKGLGILITLTPRVDPLIAELITGTKTEDVGVRNAMMKALQEVVGKAGANMSEASKNAILALIDDDASDQTDAVAITNAKLLGALVKVLPAATAGPLIKNRVLAATPSHASILGLNALLVEAPSSLTEHFSAETQAMICQGVTNKDPFISDNSVLAAGKYLLIEDENRNFEDNKAIFEALAPCIQPGTPSDTRRLSLVVMRTVSRLHPELTRPHLALLAPPIFASVRDVVIPVKLAAEAAFLAIFSVEESEGAVFDKYMAGPGASLPPGPKRSMSDYFKRVALRLAAQARERKEAEGGQGGLGLSNDEVEDERELWSIGKVDLGDGSFGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGX4</accession>
    <name>A0A8G1VGX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_524237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510666.1">
        <property type="nucleotide sequence ID" value="XM_025665404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGX4"/>
    <dbReference type="GeneID" id="37168806"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="164" mass="17811" checksum="A516755E08771D26" modified="2022-01-19" version="1" fragment="single">VAYGRVGRSGEGGSNSFNTRNGYQSAPSTRRRSDPSKPISIRGGDQRRRERVTVGRDWLLPSSLQHRQESHRGSGPEAGSTIEVITYPIREILPFAPLGILGRSLAINFSPLSGGTSPSAARYFQSVVLGITAQDESISENTIGHGVWTWYGGCPREAKTTLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGX7</accession>
    <name>A0A8G1VGX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_433142</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825098">
        <property type="protein sequence ID" value="RAH51652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509574.1">
        <property type="nucleotide sequence ID" value="XM_025658408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGX7"/>
    <dbReference type="GeneID" id="37161810"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="69"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="547"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="10">
        <location>
            <begin position="692"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="509"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="652"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="657"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="686"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="727"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH51652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="744" mass="84185" checksum="0A8E1F5EB0B57D75" modified="2022-01-19" version="1">MVKRKLGALEKVEADLPNLQHKIRRDPKSYIEDFRAQHYQYESHREIFMTAPSSTTETGLISLRELIDFIAHVADCYPEITKDFPQQLMDILSQHHLILQPELREKIVGSLVLLRKKELLDSATLLQTLFPILISTPSKTLRALIFQKILMDLRQANAKTTNHKLNRTMQTVLFNLVTSDRTSSKGLWAIKLTRELWKRQIWTDAKAVEVMKEASLASNEKVIVGGVRFFLGGDKEREEMEDESSDEEAIDLGRVKHQVGINKKTRKKSRAVEKAKATVKKRERKKNQPHPLNFSALHLLHDPQGYAESLFSKHLQSTKSKLNLDQKLMVLQLVTRLVGLHKLHIMHLYSYFQKFLTPRQPSVTSFLASLAQASHDLVPPDDLEPLVQKIANEFVSEASASEVASAGLNAIREICARQPLAMNETLLQDLVMYRKSKDKGVMMAGRGLLSLFREVNPEMLKRRDRGKDASIGLKAGERKEKRFAEQEAGGIEGLELLEKWKEEERRKRRAEKGLASDASDDEEEGEEDNWASWNVEDDEDSDDSGDWINVQSDAEIDISDSEDEKDGPPAKKAKSSESSSDDKAEKKEEEKEESAEAKFSKLATTRILTPADLAKLQELRTEAAINSLVPGAKKRDRDDPLTAEEIEGLAALSAGKATREERIAHAKEGKTDRSEHKSITAKRKERKQDQGKSTTNKEKARKKNFLMTLGKAKSKNKRSLVQTRAVLKAHHDRAKRGGRRGNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGY7</accession>
    <name>A0A8G1VGY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_433058</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825096">
        <property type="protein sequence ID" value="RAH51682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509604.1">
        <property type="nucleotide sequence ID" value="XM_025658405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGY7"/>
    <dbReference type="GeneID" id="37161807"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF44">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH51682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="534" mass="57966" checksum="A1E13C8CFAE4C922" modified="2022-01-19" version="1">MGYTTFWRRLSPRQLNVGIQALSLVCIFFEGYDQGVMGGVNSSPRYVTEVGIGEPDGTVTDTTHQGGIVSIYYLGCIFGCFGGGWLADRLGRINGLLAGSLLALVGGALQAAAQSSDFMLVARVVTGVGTGALTGIAPVLVSETSTADHRGAFLGYVFIANYLGISVAYWLSFGLAFINNGYSDIRWRFLLAFQCVPALILLLFIKMLPDSPRFLASVGRYDEAQQVLNKIRCHKCSQSEIDLEYKEIIATVQEGKPSSPLQFAKILIGKGGNPGSNLGRRAWLCIWLQIMGSWTGITAVTAYSPVLLGQAGYSELTQNGLAGGLNTIGILGTLISTQIVDRIGRRKCLMLGSLVLFVVELVAGSVYEASLHQPEKASQFAPAAVAMLFLFNLGYAATWGTVAFLIPTEIFPSDLRAQGNGFGITGWAIGVGMTTLVNPIMFASIGSRSYFLLAGLNLLWVPTIFLFYPETRNRSLESIDYLFSTSSPFYWDMERAFQSCMDGKVEKHIDEQAVKVAGQDEAQQEFHETIQQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHG0</accession>
    <name>A0A8G1VHG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ran GTPase activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_454245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510114.1">
        <property type="nucleotide sequence ID" value="XM_025661237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHG0"/>
    <dbReference type="GeneID" id="37164639"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="379"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH52192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="415" mass="45694" checksum="CB01F926F631F3E1" modified="2022-01-19" version="1">MAPPKVFSIEGKGLKLDSAEDIESHIKPLLEATDYTEIRFGGNTLGVPACERLAAVLSTQTSLEVAELADIFTSRLLSEIPDALTFLLNALLEITTLHTVNLSDNAFGANTQKPLVDFLARHTPLRHLILNNNGMGPEAGSNIAKALTELAQRKEEARKEGKEVPLLESIVCGRNRLENGSMAAWARAYEVHAAGMRSVKMTQNGIRQEGISMLLKDGLRHCSALEVLDLQDNTFTIMGSTALAGVVSSWPSLRELGVSDCLLSGRGGVKVAQALAEAKNQKVQTLRLQYNEITAEGVKQFLHATKTALPALRRIELNGNIFNEDDNNVTELREILEARQEEHGQDDDPEDMWGVDELDELEEEESEEEEEEEEEEEEKAEKLVKDDEAAENEKVSQKKDDDVDKLADVLGKTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VI91</accession>
    <name>A0A8G1VI91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_453227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511357.1">
        <property type="nucleotide sequence ID" value="XM_025661007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VI91"/>
    <dbReference type="GeneID" id="37164409"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="99" mass="11140" checksum="1BD95F701D7BD0FD" modified="2022-01-19" version="1">MTSFPCDPICVSGIARLTPTRTSPGGSSNRALPLFQTPSHLRSPSSVRHNDECWFIRTSTKYKYRMVREMRSRTTSANTRASRGILNLMLHVAKSVEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIC8</accession>
    <name>A0A8G1VIC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-dependent oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_404498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512153.1">
        <property type="nucleotide sequence ID" value="XM_025657271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIC8"/>
    <dbReference type="GeneID" id="37160673"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF9">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="55"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH54231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="484" mass="53070" checksum="3F728B30D814A927" modified="2022-01-19" version="1">MISFKQYATALIGLAQIATASNITALLSQLSPAAEVFYPYATNWTDTTQRWTTYEEPTFFASIKPNTTLDVQRIVKYASTHNIPFLAMGGGHGYTTTFAELQYGLEIDLSGFNQVAVDADANLMTIGGGVRFRDIFEPLYSAGKEIQTGSGSCVGMVGATLGAGVGRYQGIHGLIIDALESVQLVTSNGSLITVSKTQEPDLFWGMRGAGFNFGIVTEATYTIYDLTNNGSVLNADFLFPASANGSFFEILASFNGTLPQPLSLFTLVINDTTYGPSIILNAAYAGPKSEGLAHLQPFLDLPYHKRNITQLTWNVLDTSALFGMDADFCIDGDMHNLWALGVARIDVPTHIAFFNTMVDFYYAYPEATGSSYEIEFFSTQAVRAVKDEETAYPYRDITAHVMLTFAYDDASLSKPVNDLASRWISRFNATSGFDRLQVYVSYAHGTESLDAWYGAEKLPRLLELKKKWDPKGLFVYNNGLPVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIE9</accession>
    <name>A0A8G1VIE9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenosine deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_428248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512213.1">
        <property type="nucleotide sequence ID" value="XM_025658200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIE9"/>
    <dbReference type="GeneID" id="37161602"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114:SF7">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH54291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="375" mass="42962" checksum="95933331A1EC5CE1" modified="2022-01-19" version="1">MALNASVLSNKTLRDYRNTIHQHNDKFIQNMPKVEMHVHIEGTMTPELRWELAQRRGESVLNINTQQPCESLSELKSTYELLNDLDAGGVDGEMQRFFELYYGGFSVLQDEEDFYHLAMNYFRKAASMNVRYCEPFFDPQGHTRRGVPLKTMMDGFKRAQSEAVRDLGVHSQWIMCMLRDMSPESAMEHYLQALPYRDMIVGIGLDSLEVDRPPLLFEDVFLRARKDGFKITCHCDVGDKDTLRNIGQVVDQLGGSGADRIDHGLHVADDSFLLQRVKEKDLGMTICPWGYLCYSGEAQIIDRVRTLFNAGIRIAIGSDDPSYMEDIWLNNSLYLLRVLGNFTDAEFVQLQRNAVDICWASDDIKAAILMELEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIH3</accession>
    <name>A0A8G1VIH3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aureobasidin resistance protein Aur1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_161439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511179.1">
        <property type="nucleotide sequence ID" value="XM_025654237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIH3"/>
    <dbReference type="GeneID" id="37157639"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000015">
        <property type="entry name" value="Aureobasidin resistance protein Aur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF11">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE CATALYTIC SUBUNIT AUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="6">
        <location>
            <begin position="212"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH53257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="439" mass="49516" checksum="32DC8DFD753BB885" modified="2022-01-19" version="1">MNSTLPSWKDRTQNQFGKLQIQVPWRSIQLLVPHRMRRKIRSKLRSRLSPTSSISSLQTSFSPMDTLRSLQSHRWTLYDFQYLLLLILLIFSLSVMGSPGPLGKTAMFTLLLLSLLLPITRQFFLPFLPIAGWLIFFYACQFVPSDWRPAIWVRVLPALENILYGANISNILSAHQNVVLDVLAWLPYGICHYGAPFVCSLIMFIFGPPGTTPLFARTFGYISMTAVAIQLFFPCSPPWYENLYGLAPADYSMPGNPAGLARIDKLFGIDLYTSGFRQSPVVFGAFPSLHAADSTLAALFMSHVFPRLKPLFVTYTLWMWWATMYLSHHYAVDLVGGGLLATVAFYFAKTRFLPRVQSDKTFRWDYDYVEIGDSAREYGYDLAAYDGDFNLDSDEWTVGSSSSISSGSLSPVDDHYTWEGESLASPIADVESGRHMLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIW6</accession>
    <name>A0A8G1VIW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Long-chain-alcohol oxidase</fullName>
            <ecNumber evidence="5 12">1.1.3.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_100809</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:22756"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="EC" id="1.1.3.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.20" evidence="5 12"/>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512708.1">
        <property type="nucleotide sequence ID" value="XM_025653773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIW6"/>
    <dbReference type="GeneID" id="37157175"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012400">
        <property type="entry name" value="Long_Oxdase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056:SF12">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028937">
        <property type="entry name" value="Lg_Ch_AO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="15">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="14">
        <location>
            <begin position="269"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="16">
        <location>
            <begin position="584"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH54786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="749" mass="81719" checksum="84D4C171A7814419" modified="2022-01-19" version="1">MAEPASQYVPLDVPLPPVPTTKIFTEEQWTTLLSLADTVIPSIRSPTAYKSASTKAIPHSELNKSLATLTKSIHSPDAGTIAAQYLEEDASSNPLFREGLQRLFAQYVHDEGRNGLGFILNALNTRAGSLLLTGSVTPIHEQPLHVREEIFRGWETSRLSPLRGVYRACTGMFKQTWVKFSPTLAPVLGFPRVPVHGKPADGFKHTFLQFPAADEPETIETDVVIVGSGCGGSVAAKNLAEAGHKVLVLDKSYHYTSNHFPMNFNEAFNSMFESGGSVVTDDGSMAVLAGSTWGGGGTVNWSAALQTQGFVREEWAKNGLPFFTSMEFQNCLDRVSDRMGVDVEHIKHNKTNRFILEGARRLGYAAKTVPQNTGHTEHYCGYCTLGCHSTGKKGPTETFLADAATAGATFIEGFRANKILFTDTKDGQVASGVEGVWTSRDAYLGRSGATAVTRNVTIKAKRVVVSCGTLQSPLLLLRSGLKNPQIGRNLHLHPVAIAGAVLDEEFRPWEGAALTTVVNELENLDNQGHGVKIEALSMVPAAFLPLFPWRNGLDYKLWVQKLPRMAGLIMLARDRGTGRVYPDPGDGRIRIDYAVSPTDRKHIVEGIIASAKMAYVSGAKEFHTSWREVPPFIRPVESDAEDTEGANNAALQAWIAEVRRKKPLDPERTMFASAHQMGTCRMGKSPRTSVVDSDCQVWGTRGLYVVDASVFPSASGVNPMLTNMAIADRASRNLARSMRRGDQNFHARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ83</accession>
    <name>A0A8G1VJ83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_453996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510400.1">
        <property type="nucleotide sequence ID" value="XM_025661176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ83"/>
    <dbReference type="GeneID" id="37164578"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="95" mass="10115" checksum="9DE1B0D5BC2249A3" modified="2022-01-19" version="1">MTQRDDDDDDGRAAGRGGGMSTGRDARGNKRGEGEGGETEKGIRIRKGRNEGRELARGHILLLLPPPLIVLGCPTTIGSSSPEYAESLEGIRNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJK4</accession>
    <name>A0A8G1VJK4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_521888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513443.1">
        <property type="nucleotide sequence ID" value="XM_025665223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJK4"/>
    <dbReference type="GeneID" id="37168625"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034064868" evidence="1">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="60" mass="6773" checksum="B9A0A7CA9F9F5EBB" modified="2022-01-19" version="1">MALDLGRNIRRRLTFALGFIFFCAPCLPHGTMTDGTWSDDDGRCARRYLGVVCDDTQRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJK7</accession>
    <name>A0A8G1VJK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_452330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512304.1">
        <property type="nucleotide sequence ID" value="XM_025660800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJK7"/>
    <dbReference type="GeneID" id="37164202"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01066">
        <property type="entry name" value="APP_MetAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050659">
        <property type="entry name" value="Peptidase_M24B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112:SF8">
        <property type="entry name" value="CYTOPLASMIC PEPTIDASE PEPQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="1">
        <location>
            <begin position="15"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="230" mass="26119" checksum="65D2E8EF86F76CD3" modified="2022-01-19" version="1">MSTSIESDRAAYLLDAQNKAVQLFEGIEQDLIRPGVSEKTLSTEIHELGAKRHGVRTHWHKRVVRSGPNTLSPFAENPPDRIIQPDDILVVDLGPVFEEWEADFGRTYVLGDDPAKLKLRDALDPIWHTVKRRFRENPDMTAEELYAIACQEVQQAGWDFGAPIAGHLVGSFPHERIPNDKISLYIAQGNRDKMMVPGRDGHMRHWILEIHIHDRARGFGGFCEQLLTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKV2</accession>
    <name>A0A8G1VKV2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_34299</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515076.1">
        <property type="nucleotide sequence ID" value="XM_025655463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKV2"/>
    <dbReference type="GeneID" id="37158865"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977">
        <property type="entry name" value="TARGET OF ERK KINASE MPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="147"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="104"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH57154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="237" mass="26412" checksum="681F57CB8678CE40" modified="2022-01-19" version="1">MVQVSSLALVGYLAPVLVTFLLFITWLILGTRRRRRRRRHLYGSTYPYSDAEMAAAAGGQRNPRMVISQQLIEVLYPQVKYKYWLAGKQNEQQQQEDLPSGAIAQVRSTPGDNTSGESPVNTNINDSQERDKDTEDADTSGDNHRTCAICIDQFADDDDIRSLPCRHIFHTVCLDPWVTKKNAFCPLCKRALCGVKKGDSGSGGDRRSWPWRRGSQRASARVVSVSVPEAAVVRGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL34</accession>
    <name>A0A8G1VL34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_422186</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515108.1">
        <property type="nucleotide sequence ID" value="XM_025657959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL34"/>
    <dbReference type="GeneID" id="37161361"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="37"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH57186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="292" mass="31429" checksum="8C1636430C829041" modified="2022-01-19" version="1">MTTRSDCNVHGLEFREAKPSQGDPARPVADLFRLDNRTIIITGATGFLGTTLAIAILESGGDVVCLDLAPVPNSPDWHKVEAAAQSHARQLTYYPLDVTDESNVEKTFTQFIPTLRYPLKGLVACAGLSRNGPATEFPVSSFRRMLDTNVTGTFLIAQAAAREMLRTNTTGSMVFVASMSGYVSNKGVDTAGYNASKAAVHQLTRSLAAEWGSRVGMPLIRVNSLSPGYIRTAATAEALQKPGMESQWVGDNMLFRLSTADEFRAPVLFMLGDGSSFMTGADLRVDGGHCAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL47</accession>
    <name>A0A8G1VL47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ArfGap-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_374606</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514282.1">
        <property type="nucleotide sequence ID" value="XM_025656137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL47"/>
    <dbReference type="GeneID" id="37159539"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000013">
        <property type="entry name" value="Putative Arf GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="455" mass="48555" checksum="3127DF3D04598869" modified="2022-01-19" version="1" fragment="single">QICFDCGSKNPTWSSVPFGIYLCLDCSANHRNLGVHISFVRSTNLDQWQWEQLRVMKVGGNESATKYFQSHGGSAALASKDVKVKYTCNAAVKYKEELKRRAAQDAQQYPGEVVITDIPAGTPSNGSSTPAAEDDDFFSSWDKPSIKRPSNPPSRTGTPPVVSRTGSPFLNSGANGSRSKSPLSASDKDSSSPAPTAIRASTAVRKTPSTTTAKKGSVLGAKKAPKLGAKKIGAAEIIDFDEAERKAKEEAERIEKLGYDPEAEQAEADAKAKTTTTAATAIASPTPISPSRNTQERSSGDVERLGMGIGRLGFGQTVGVKPAAPKKPGFGAVAPRSAADDEELKQAKSRFGSQKGISSDEFFGRDRFDPNAQAEAKERLRQFDGAQAISSNSYFGRPEDDLPVADDTYGDLENAAKDFVRRFGITAGDDLENLTQLVGEGATKLQGAIRSYLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLS6</accession>
    <name>A0A8G1VLS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_487922</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516036.1">
        <property type="nucleotide sequence ID" value="XM_025663490.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37166892"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    <keyword evidence="14" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
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    <sequence length="4049" mass="452006" checksum="A330862E9565B4A6" modified="2022-01-19" version="1">MGRIKKVASQKHEATISPYLADFVARATTIPVPELPSHLNTFSRIWPFPRGDLYHWINVLNRFDEILASAIEKYALNNGPQTKPFGKDFLVESYVHGESAGKPQDVDAKLAELGYGPEGDRELLEVILDFSRLLLEKCGNRSLYSSSERLGELLNTTSLSLLQSTLRLSLCLAQRYHSRQRGGSHIQHSLLAAHYNIDLEKLQKVAAPFPRPSVPGRTAVSPVASIKSKEKASQARHNANDMSVLVRENESWDEWGNVRLLYYPSGSSEPVKTAPETGTGGPSVQAPTTPTPLRRSHTHPTPRLSRMSTAEDSPASVTSTPGKQDETLRGGKTLELPYSKISSTSAEELVAAHVDEVPDDSKYELLHRIRTAQGLATSDSTREQILAIRILALTNLAYVYPEPLFQQKVLQYDMEQPKRLQLAYQLGELVHLGASGDLPVSRTLQTLALQALDALAKHKARAIDVCGALSVNVNHGVLMFLTRKTVNELGSEDTDGEDGSQDEWRDALLALLRTLPGSSTRTPETLVAAGLIPMFVDVLNLRTEKARRVYSRIMEFLDTFVHAVRDALGTLTSAKGFDAISDLIDHETKSSFENVNRGAGIPSQHKTPSIDYQIPYFQQQALRWMFRFVNHIMQHNGGGFDRVLRNLIDSPQLLTSLRLVLENARVFGSHVWSNAVNILSSFIHNEPTSYAVIAEAGLSKSFLEAVTSSELKAQEKIVVEPESADVEGETSRLPETSATETTAEDGRGPREYTIVRSAETRLAPGIMPAAEALSCIPSAFGAICLNSSGLDLFKSSDALESFFEIFENPEHVRCLKDDPNLVRSLGTTFDELVRHHPALKAHIMTAVIVMVARVGLLCRAKAWSVGMGAKLWTENPDGKPIISGSTAHLLKAIGIDNGDQAEDASTFGVPQLTSDQLPNGGKLQLGDLSQILPSSNDNIEPKETDAAGLTATDYLYPVVRFLGAFFENQPNCSYFIESGGVEFVLDLATLQSLPYDFHNTDANQELAVLVHMLAETKPHLVVPSLVQRTERAVDMLSSFWQEPNHSGFFTPLIMATSNSTSEEKGKETLSISKANGTFFAKHMGAALILTDFLREIYSMPLYQTRPSQQTSAFAQVNLVDRYCSLVNKLGGLHAACVWEEILLEKNIPDTWDQATKVQQTGSAPERSNPVAGQLNSEGNTIVPGTEPSRESPAASDSAQPGVAQESKEPTTAKVAEDGVAFKNVQALRYLLSSLPSSITGFFHNLGLGLIGKRRTDLYQKQNATLVADAVAGAVLEQLQFQPPNASDNSKLRFAYLIVILSSFSHLLFEATADRPHSHYLTLVLFSFKRHGGLKVTKDICDLFVQEVKALTPPESVAESEQDVSARLTSAYGGIKIILSFFSELASGKNIVDSSQTQAMTSDRDRDRPDYFQPGQFLVDLRMEILPMARDMWNSDFAAQSSSSVVKCLIDILRSSLDGEYETGAARSSDVPPMVTDVARRMFVVNKDRMVSLQEKGFDGQLAKEALYRCNNVYAAAEEYCRAQSRLRAPPRAEPSPGDIESIRSTSGAEGSDEPASDAPSFDNGFLERSALAMLLAQASGRPADDASRQDQGQGRSEDSEVRHGSEFLARALTHILNDDHATGSDEHEESPIITPRISNAPGGSSSEPSTLPANQSPEQRSEQPTRRREVTTIEDLDKEREQVRSNLIERCLDILNEHHDVSFELADLIASATRRHRDAESFRREVGEILVQSLVSLQMENFQAAGRKVAAYAHLLALVVQDREMYTATLGELKECFTTFLGFIQVLPEKSSDESFPWIGHVLLVLEKLLSDDCQPPQIRWTIPDHENPSADDEQPAHLEEPLVSLDQKMQLYEALVEILPRIGKDETLALSICRILVILTRSRSIAVRLGEKRSLQRLFVMVKQLSSSTNEKLQGAFMLILRHIIEDEDTIRQIMRSEIVANFESKSSRQIDTTGYVRQMYHLVLRSPEIFVEVSNEKLKLQRYDNRQRPQILTLKADKKNSSSDPTTVKEAPDSPEKSEGQTGGASSEDKDKAKSTDLKPPVVENPDGVIHYLLSELLSYKDVDDKEAPTESTDPSAPDQSETQTDVEMSIDEPSPSVSSTDAQATRNSKKSDKPAFKADDHPIYIYRCFLLQCLTELLSSYNRTKVEFINFSRKADPHAATPSKPRSGILNYLLNALVPVGTMEHDESVSFKKRSNTSAWTMRVLVALCTKTGEFGGPGRRRNEQELNEDDEPELAFVRRFVLEHALRSYKEANASNEPLDAKYSRLMSLADLFDKMLSGYAFVSGETAFASSTRQLAKTMFEKHFISALTASVAEIDLNFPASKRVIKYILRPLNKLTQTAVVLSESSDISTLAETEDDEISSATSVSDMEDDREETPDLFRHSTLGMLEPRHEEETSSEESEEEDDEMYDDEYGEEMDYDEDLPEDDGEVVSDEEDEIEGVGPIEGLPGDNGMDIEVVIDDDEDDEDDEDDEDDEDDSDMDDDEILAGEITGDHDNESLEEGDDDEWESEEMSEDDEEAEIMNQFEDELADSLRQAEQRDDGQRFDDLFRVLNEAAGGVEDLQADSLGDMHEDIVDDDLADEEEDEELEELEEELEDADDDQGSYQGFDDEEDLMDPWGWEGDEQPPRGHHHSRFHGPRPAWAAVSGIMPSRHGIVPIQPYRLHRTQIPARGNDDGTNPLLVRTDRGSETGGQPRVPGNEAFTDWVHGMEPVSTGRLLPMDSPVSFMNAVLQAIGGQGGPGFGVITRPDGIHVHVDRRAMPNRIQDIFGLGRPQAPPSRTRDDPSQAVSFALATTRSRWQEEARILFSSAYVEKTQRVVNSLLKILVPPAIEEEKRREKQMEEERKRREEERAERERQERIAREEEEKERKRKEEEENARRQQELERQEAERQASGIETEPMDDVQRTDTGNEAAAPAAETDAGPSEPAPRVHTTIRGRQLDITGMEIDPEYLEALPEELREEVIMQQLAEQRSQAAAAGEEPSEINPEFLEALPPEIREELLQQEAADRRRRERDSARRQAAAAAGAAAPAPAPVHAEEMDPASFLATLDPSLRQAVLADQPEEILATLGPEFLSEARALPGRRLAQFGDITRVDHRHRREPADDQEPKKQQRRQIVQMLDKAGVATLLRLMFMPLQGNARHQLNDILHNVCENRQNRMEVISLLLSVLQDGSADVSAIERSFAQLSLRAKPSSVQKTPQSVKRNLSFQGSSNVSNEVTPIMVVQQCLGTLSFLSQYNPHIAWFFLTEHDSSPALKLKALRKGKGKENRANKFALNALLTLLDRKLIMENPNCMEQLSSLLSSITQPLTLLLRREKEKQEEEEKAKGKQPEQAREERPTEEQEQQQPVPADQTGSATDTTMTDAPLPTVETTQPQTETAQPGQTEPSEAAKEEKAKTTAEEEKHKRRTIEPPVVPDHNLQLVVHILAARECNGKTFRDTLSTINNLSAVPGARDVIGNELVSQAQTLSTVILTDLDELLSHIHQARTGTDMQGLALAKFSPASSDQAKLLRVLTALDYLFDPSRMDKVKGAEPDNAAKEDVLQTLYECSTFGPLWTRLSECLTVIRQKENMLNVATILLPLIEALMVVCKNTTLKDTSLARNSRELSVSTTSVDAGLSMESLFFKFTEEHRKILNELVRQNPRLMSGTFSLLVKNPKVLEFDNKRNYFTRRIHSRGAEPRHPHPPLQLSVRRDQVFLDSFKSLYFKTADELKYGKLNVRFHGEEGVDAGGVTREWFQVLARGMFNPNYALFIPVASDRTTFHPNRLSGVNSEHLMFFKFIGRIIGKALYEGRVLDCHFSRAVYKCILGRSVSIKDMETLDLDYYKSLLWMLENDITDIITETFAVETDDFGEKQVIDLIENGRNIPVTEENKEEYIQRVVDYRLVGSVKEQLDNFLKGFHEIIPSDLISIFNEQELELLISGLPEIEVDDWKVNTEYHNYSASSPQIQWFWRAVRSFDKEERAKLLQFVTGTSKVPLNGFKELEGMNGVSRFNIHRDYGNKDRLPSSHTCFNQLDLPEYESYETLRQRLYTAMTAGSEYFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM46</accession>
    <name>A0A8G1VM46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_522196</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Preautophagosomal structure membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATG12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513265.1">
        <property type="nucleotide sequence ID" value="XM_025665241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VM46"/>
    <dbReference type="GeneID" id="37168643"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000148">
        <property type="entry name" value="Ubiquitin-like protein ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 12" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <keyword evidence="7 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH55343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="170" mass="18423" checksum="DF3D91DF7EDA6BAF" modified="2022-01-19" version="1">MDSPSPQGLSAQNSPKPDQAKLTHRPANRKQSSDSSSNTQNAPIPDDKHGADLPMTMSASVVLTSLPRDAHQALADAEAVDTGKVTVRFQPLPSAPILKNRVFKISASQKFETVVKFLRKKLDCKESDSVFCYVNSVFAPGLDEGVGGLWRCFKTDEQLIVAYSMTPAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMM7</accession>
    <name>A0A8G1VMM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_421565</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515604.1">
        <property type="nucleotide sequence ID" value="XM_025657932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMM7"/>
    <dbReference type="GeneID" id="37161334"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="30"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH57682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="501" mass="53769" checksum="CA8C9B810E2AFC05" modified="2022-01-19" version="1">MTWNLRGLVPGQSDTKPPVFLKWRSSNAFIIFVVVFAVFTDVLLYGLIVPVAPTALHERVGMSVDQEQSWTSILLALYGAALLAASPVAGYIADRFESRWWPLIVGLLALGASTALLCVGTHLSLWIIGRIFQGASAAVVWTVGAALLVDTVGKDGLGQAMGYIGMGMTFGIMGGPLLGGVIYARGGYYAVFALAFALVGVDIVLRLVMIEKKHAVKWLQQEKEQGPVISPSETTEKCSDIEDATDPLPAGASDDKSDDPVSVGQQAVETSGHASPKKTRSAVLTLLASERMIVTIWAYFIVSVVLTSFDSVLPLFVEDTFGWDQTGQGLIFVPLSVPHISDPFFGWINDKFVNARRYMAAGALFTTIPFMVLLRLVTHDSMGQKVLLCALLVLIGFCIASLMPPLLVEASYIVAEKEAQDPDIFGKGGAMALSYGILNSAYAAGTIVGPFFAGFIRENAGWKTMTWALALLTGVSGVPILLFLGGFLFKKKRSETAPSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN13</accession>
    <name>A0A8G1VN13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_368551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517341.1">
        <property type="nucleotide sequence ID" value="XM_025655874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN13"/>
    <dbReference type="GeneID" id="37159276"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="49" mass="5652" checksum="530CE864D02D335D" modified="2022-01-19" version="1" fragment="single">FFLPLASKQATQRASFHLSSSKPYRLGGFQNGMVVICYVSWRFVCVYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNC9</accession>
    <name>A0A8G1VNC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ser/Thr protein phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_512861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516577.1">
        <property type="nucleotide sequence ID" value="XM_025664676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNC9"/>
    <dbReference type="GeneID" id="37168078"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="338" mass="37468" checksum="3A05611D9E369EB5" modified="2022-01-19" version="1">MTTVKTSILLLSDTHTLTPSPPTHPPSSTPYRHPLPATDLLIHAGDLTKVGHKHEHLTTLSFLQSAPAPLKLIIPGNHDITLDEPYYKRIGHYRHRYRTDHTAPSATAGSDNVSAGKLTPGQGLSDEELREIKELYTGQEAQDAGIRYLEEGMHVFRLGNGAVLRVYASPYTPEFCQWGFAYPREVDRYNPPEEEEEGGDGDGGIRKVVPDYPGVDVMITHGPPYGVLDQVVPNHMSVGCEHLYRAVKRARPRLHVFGHIHEGYGATRREWSSGNESVIQCDKERTLEERCARVDVSGEGGNGLRVGEETLFVNASVVTVQYHAVNAPWVVEMDLPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNK8</accession>
    <name>A0A8G1VNK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyamine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_467690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516817.1">
        <property type="nucleotide sequence ID" value="XM_025662207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNK8"/>
    <dbReference type="GeneID" id="37165609"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF313">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034756416" evidence="1">
        <location>
            <begin position="20"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="296"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="380" mass="42391" checksum="6A80124C74A22562" modified="2022-01-19" version="1">MKLASTAATLTAFAVLGNAKICTETEVVILGAGVTGVTATETLHNNCVEDFIVLEYQDRIGGRMHEVTFGKGQQYVVEAGANWVHGTGGPETHATKANLRTLTSDDENATVYDQTGEIPPELLFNALEAVSEADSKVLADAGTRLYHHLEDRTYRAALRRQGWNPKETNHSQGGRNFRDLYRSNHECDGQVLLSPRGVQLRSTWFAIILRNVADPLFEGQNAWRLRKNTIVNEIEHDDDSVTNHSTDWKCVRAKYAIIKFSLDMPLRASNGHVYQNIHAISAFLPAQEPPLDVPGAHRVERQSEDKTQAEIMEVLHKIFGDEAVPEPIDIYYARWTQKPWSYGSYSNWPPAVSAQTHQNLRANVGRVLGRDGATLFLEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNQ9</accession>
    <name>A0A8G1VNQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_513222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516774.1">
        <property type="nucleotide sequence ID" value="XM_025664698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNQ9"/>
    <dbReference type="GeneID" id="37168100"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="139" mass="15753" checksum="3E48B742893AB095" modified="2022-01-19" version="1">MADDLFDVSQWQFSTTWLYLPCTEEYWNRPDQFQRAIDDIDTLTYAIYNYNPAIPPTMRGVLLAVYHPLDYDTSSILALARGDLVNYQIAAAGQPGLMGPSQSTICLPLNESTIYLSLNEADYMDISEDASMSTVFQWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNW9</accession>
    <name>A0A8G1VNW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_260324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516939.1">
        <property type="nucleotide sequence ID" value="XM_025655021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNW9"/>
    <dbReference type="GeneID" id="37158423"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="151" mass="17310" checksum="BBF86371DE223EE4" modified="2022-01-19" version="1">MCKGQGLRRSMGWAIPKLTFSIREVVSDKLYKGGRRIHSQHRSLSWRQLFSYHVHQYYHLVRQLISCHVGARGTVVIESQFPYRSTYMMYHSKPTIRSSEILWSSLLPGVINPRIANKRIPNSCPFESGETRLPIASGPGRTTSGATMRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPB7</accession>
    <name>A0A8G1VPB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_488303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515500.1">
        <property type="nucleotide sequence ID" value="XM_025663521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPB7"/>
    <dbReference type="GeneID" id="37166923"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH57578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="62" mass="6975" checksum="1ADD8620BAD58D6F" modified="2022-01-19" version="1">MGKVHGSLARAGKVKAATPKVEKQEKPKSPKGRARKRLVYTRRFVNVTLTGGKRKREEESLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPC5</accession>
    <name>A0A8G1VPC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Diacylglycerol pyrophosphate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_244538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517449.1">
        <property type="nucleotide sequence ID" value="XM_025654869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPC5"/>
    <dbReference type="GeneID" id="37158271"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF154">
        <property type="entry name" value="PAP2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G09730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="112"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH59527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="360" mass="37988" checksum="7DFA393523C12A3F" modified="2022-01-19" version="1">MASTPQADADFDMLSTQPRRTSKNVIASYVLDWAFIIILVITGGILYKITGSEHVFSLDDANISYPLKSDTVSITTVGIVSCVVPAVLIAAICLLTPLPWPRRLWEWHAGWLGLALSLAGAFFLTSGLKDVVGKPRPDLLARCQPDLANLTTYAVGGLGLQRTESPIMVTSAICKNPDATVIKAGFAAFPSGHSSFAWAGLLYLSLWLGAKFAVSVPVRSMSFSAGGGHKKTGSSFSRASAVAAPPLYLLVLIAVPVGGALYICASRYMDYMHAGWDILGGSLIGIVFAILGFMWYHAPAGQGYGGWAWGPRQRVGAFGAGFGDGVCTGSGRRNMEGGRDGYQDLELGAMRASRGVMGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ96</accession>
    <name>A0A8G1VQ96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_458736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516460.1">
        <property type="nucleotide sequence ID" value="XM_025661602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ96"/>
    <dbReference type="GeneID" id="37165004"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="32"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH58538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="146" mass="16530" checksum="734CA114A1019D0A" modified="2022-01-19" version="1">MSLLPHHPRPVPSLLRAFTDLDNYLTTSTATDSLFANSPRFDLRETKDAYILDGDLPGVKKEDVTIEFTDPSTMNVRGRSVRSTEGEDGNWWFSERTMGEFRRSFSFPAKVDREHVDAKLTDGVLSIQVPKVGGEVEEERKVIDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQJ7</accession>
    <name>A0A8G1VQJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_419765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516760.1">
        <property type="nucleotide sequence ID" value="XM_025657874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQJ7"/>
    <dbReference type="GeneID" id="37161276"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="427"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="480"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH58838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="578" mass="63905" checksum="8F89B6697676F536" modified="2022-01-19" version="1">MSSELDTQVSYDTDIRVSLPFLQAARQRNYDYLTSLLAEGHHPNKRDENGYMALHRAIIEAPEDLTTVAMLLTYGASPHAFFRPGNSSLEITPLHYAAMRGDVGLVSLFLQHGKKDVTPRTLKYWTTPLEDAISYGRLSVVARFIEFFSSSQLLHKPTRGIDESIILAAKLWYSKALTLLLDYKKHHMYPNPSGFDVLKHAFCEAIRPEACTSSVQGITERTGKPGDNTPSKCAHLLIQAGIRFRDDEMDRLLSITCSNAHFIGVTRLLLNMGPRVTGDHITRAIESQSYHMVKIVTKYVISSGGEAAMRRDSEPDLIQYAAGHGNLDTFEYLSTALSTTSSQSASMPTTESRKTPLIHYAVWGLRLDVVQHLLSTRSLSANEKDEYGHSPLMYAFDIADPSDENTRLAIIQLLMQHGVDIKASSIEGLTALHLAVRLGVTPAVQLLLEKGSNPNAKTATGSDLYLRRNPSFWSPETNARLRTPLHWAVDRLANVSVDVVRLLLHYGADMNAQDGNGVTPLNLLLGDGWCINGAWNARIGVANLLLSYGADVDIRDMSGISARQRVDQRDAELHASAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQU9</accession>
    <name>A0A8G1VQU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">sterol 14alpha-demethylase</fullName>
            <ecNumber evidence="12">1.14.14.154</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">BO85DRAFT_445854</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>32-hydroxyeburicol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxoeburicol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75431"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:194328"/>
            <dbReference type="ChEBI" id="CHEBI:194329"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:75432"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>32-hydroxylanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxolanosterol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75107"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:75108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>32-oxoeburicol + reduced [NADPH--hemoprotein reductase] + O2 = 14-demethyleburicol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75435"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:194329"/>
            <dbReference type="ChEBI" id="CHEBI:194330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:75436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>32-oxolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75111"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:75112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 14alpha-formyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a Delta(14) steroid + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:68068"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:68069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 14alpha-hydroxymethyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-formyl steroid + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68064"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:68065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 14alpha-methyl steroid + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = a Delta(14) steroid + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54028"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:54029"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 14alpha-methyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-hydroxymethyl steroid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:68061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>eburicol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 14-demethyleburicol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75439"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:70315"/>
            <dbReference type="ChEBI" id="CHEBI:194330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:75440"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>eburicol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxyeburicol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75427"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:70315"/>
            <dbReference type="ChEBI" id="CHEBI:194328"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:75428"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>lanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:25286"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:25287"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>lanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxylanosterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75103"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:75104"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 26">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.154" evidence="12"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520356.1">
        <property type="nucleotide sequence ID" value="XM_025659364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQU9"/>
    <dbReference type="GeneID" id="37162766"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008398">
        <property type="term" value="F:sterol 14-demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000033">
        <property type="entry name" value="14-alpha sterol demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 25 26" id="KW-0349">Heme</keyword>
    <keyword evidence="9 25 26" id="KW-0408">Iron</keyword>
    <keyword evidence="11 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 25 26" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="28" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10 26" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 26" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="28" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 27" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="25">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00052067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00052625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="RAH62434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="524" mass="58907" checksum="460945F2191CC53F" modified="2022-01-19" version="1">MGLLAVVLDSLCERCSNTSILVLLGIGLSSLLAVSVILNVLRQLLFKNPNEPPLVFHWFPFIGSTISYGMDPYKFFFDCRAKYGDIFTFILLGKKTTVYLGTRGNDFILNGKLRDVCAEEVYSPLTTPVFGRNVVYDCPNAKLMEQKKFVKFGLTSDALRSYVRLITNEVDDFVEHSAAFQGSSGVFDVCKTIAEITIYTASRSLQGKEVRSRFDSTFAELYHDLDMGFAPINFMLPWAPLPHNRKRDAAQKKMTETYMEIVKERRTGGNKKDSEDMVWNLMSCVYKDGTPVPDEEIAHMMIALLMAGQHSSSSTASWIVLHLARNPEIMEELYAEQIRVLGSDLPPLTYENLQKLDLHAKVIKETLRIHAPIHSIIRAVKNPMPVDGTPYVIPTSHNVLSSPGVTARSEEYFPNPLKWDPHRWDETIAANAEEEDQIDYGYGLVSKGTNSPYLPFGAGRHRCIGEQFAYVQLGAITAALVRLFKFRNLPNVKDIPETDYSSLFSKPAGKSIIQFEKRATTVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR55</accession>
    <name>A0A8G1VR55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_107664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519472.1">
        <property type="nucleotide sequence ID" value="XM_025653836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR55"/>
    <dbReference type="GeneID" id="37157238"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="248" mass="28605" checksum="B87BF0C407C0FB9C" modified="2022-01-19" version="1">MGIPRPQEHWVDAPQTNSTKPSPFLKLPLELRLMIYEYALVVPNEFTDRPMIVINDRGNVFTARGRYRALSMCPSWVGENGRVRSLLSVNRQIHDEVEDFVYSQNTLFFLNSFNLDRLGTFLDTISPTARKRIRSVGFEIFFFVHSQTGVPKRTLKEYKAAARMLMEKLPNWTSTMFYLDPRFYFPSAAVGNLESSARGIWYLATIFGALQKDLHFFPLPSMHRHVMDDAKKSLQAETRASQMKLSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRJ2</accession>
    <name>A0A8G1VRJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">mRNA transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_455159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521046.1">
        <property type="nucleotide sequence ID" value="XM_025661371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRJ2"/>
    <dbReference type="GeneID" id="37164773"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000266">
        <property type="entry name" value="mRNA transport regulator MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF53">
        <property type="entry name" value="MRNA TRANSPORT REGULATOR MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="3">
        <location>
            <begin position="34"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH63124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="971" mass="108920" checksum="BC4765BD0DCFAAD7" modified="2022-01-19" version="1">MASKEGTAGQSFSAVLAAVTTMSGNVSRSEKEHAHEFLEKFQKSVEAWTITHEMLQSPDVPVEAKLFAATTLKGKIIFDLDQLPAESILALRDSVLNLLVAYAAGPRPIQTQLCVCLASLAIQMLDWKDVLPTVGAALGSSAGDCVLEFLKILPEEVTEGRKINLSEEDLDSRTKELLEDNAEQVMHLLIQYAQSSPTASTNPRLLDCITSWMREIPASKIVDSPLMDVILKALDDDRSFESAVDSMCTLYRDTREVDDSLPIIQALYPRLMSLRPKIAEFAEAEDTDAYRGITRLFAEAGEAWVVLMARLPTDFRGLVEAVLECCARDWERDAISLTFVFWYELKQYVTLERYADARTGFSDIFSSLVDIMVKHLEYPRPEEGETDLFGGDREQEEKFRHFRHAMGDVLKDCCAVIGVNECLTKAYQLIQQWVSKYASQSSDDHVPNWQELEAPLFSLRAMGRMVDPEENVVLTQVIPLIVQIPNQEKVRFQAIMALARYTEWTAQHPETLEAQLNYVISGFQHSSPEVVQAAALAFKFLGTDCQKLLGGHIAQLHSFYESVLDKLKPASQEEITEGVAAVVAVQPLEKIYETMKLFCDPIMARIMNLANNAKDEEGQRAVADHLQLITIFILVVNPYVSPREENPAVKYCGEILPIMTTIVMNFTSSTPILERVCRCWRNMIISYRTAMTPLLPTLAQSLASGFEASREGCFLWATDAVVREFSEGAEFVDPSTSHAVFQFYEQQAVAFLRTLNDLPPENLPDVIEDFYRLSSDAVRYYPKECVTSSLSVPIFSAALSALTLQQIDPLMATLHYYHDLFSFAFDKPTVSEFTTSDGSSYTNPPEIREAVKQLIASQGQLLTQHILTGMMFSFPGECFPDASSVMMMLFELMPEEAGTWLQATLQMLPAGTMKPGEAERLLKGIFDKVHSGEVRKIRVLLQDFTNSYRRRNVAPREGLGRLEATRFRFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRQ1</accession>
    <name>A0A8G1VRQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/FMN-containing isoamyl alcohol oxidase MreA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_444613</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521241.1">
        <property type="nucleotide sequence ID" value="XM_025659059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRQ1"/>
    <dbReference type="GeneID" id="37162461"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034913576" evidence="3">
        <location>
            <begin position="19"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="120"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH63319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="581" mass="64069" checksum="5D04DD2078EE53B6" modified="2022-01-19" version="1">MFSGLLLLLASLVALLSAVGNAAVTIQSNTTCRCFPGEKCWPSPAEWTQFNESIDGRLIQTIPLGKPCHTPSYQAGVCDYLREQWTEPEIHYESSSSIMAPWFANGSCDPFHPIAKPCTLGNYIVYAVNVSQPSHISRALAFATAHNLRVVVRNTGHDYNGKSTGAGALGIWTHHLKDIDIVDHHDSHYSGKAIRLGAGVQGYEAWEAADAHGYQVVSGECPTVGIAGGYSQGGGHSALSSRYGLAADQVLKWEVIDGTGRFITATRDNEYKDLYWALSGGGGGTYGVVWSMTSKLHTGTPVSGLNLTFTNTNISQDTFYSAVGLYHSLLPAIVDAGAMSIWYFTNTTFYIAPLTGPNIPVQELISLLKPFRDGLEKMGIRYTLYAEQFPTYLAEFNGMMPNIPVGEAQYGGWLIPRSVVHENNTALTAAYRQITEDGATFIGVGLNVSKALVGDVDNAVLPAWRDTLIDTTLTTPWQWDARQDMLVQQYKMTYEYLPLLERLAPDSGAYMNEGDFRQPNFQKAFYGVNYPRLRQIKKKYDPLDVFYAQTAVGSDEWTMYPDGRLCRVSISDDDTDGWEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VT31</accession>
    <name>A0A8G1VT31_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ARCA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_411607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521497.1">
        <property type="nucleotide sequence ID" value="XM_025657530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VT31"/>
    <dbReference type="GeneID" id="37160932"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29948" checksum="B5A71AF7242BCC41" modified="2022-01-19" version="1">MSTSPDSGNLHAAYWVILRQEALTAFAKQRPFRIPLGPCLSYRSFEPADDFVWTNRLVIHLADVLQFCFGVDEKLSTAAQQRLSPQKTTSESSTANTDMSLSERLARYDKLVAFGTYWEEHKPPSFVPIYARDPDCLRGEVFPEIWFLGSCHAIGIQHLELARILLTVYNPKVVRLGLNRQATLLSIDHEVKTIVLRLCGIATTHRSVVPALLTACIAIAMCGDRFTDHSQQEALLSILVELEEEHAWPTKATQIQLKDAWGWKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VU88</accession>
    <name>A0A8G1VU88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aspartyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_443944</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520525.1">
        <property type="nucleotide sequence ID" value="XM_025658905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VU88"/>
    <dbReference type="GeneID" id="37162307"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF4">
        <property type="entry name" value="VACUOLAR AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH62603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="516" mass="55944" checksum="1232D5BDBA361368" modified="2022-01-19" version="1">MAKKNIMGLREAAMAYRPSSSGHLPDPVQDYSPVSPAPTAQPTAGPGSVNPDDYAKPYCEFMTANPTIFHAVDGFTKQLESKGYKRLPEREAWTSKLERGGKYYCTRNSSAFIAFSIGKDYKSGNGMAIVAGHIDALTAKLKPVSKLPTKAGFQQLGVAPYAGALNETWWDRDLSIGGRVLVRDPSSGKVESKLVKLDWPIARIPTLAPHFGAPSQGPFNKETQMVPVIGVDNSDLFQQQTSSTTSPFAAGSFASTQPEKLVKVISKELGITDYNTILNWELELYDSQPAQLGGLEKDLIFAGRIDDKLCCYAAQEALIASPDSTSPGSVKMVGMFDDEEIGSLLRQGARSNFMSSVMERIAEAFAPSYGPNVLAQTVANSFFVSSDVIHAVNPNFLNVYLENHAPRLNVGVSVSADSNGHMTTDSVSHAFMKRVAERCGSTLQVFQIRNDSRSGGTIGPMTSSRIGMRAIDVGIPQLSMHSIRATTGSRDPGLGVQLFKGFFDYFEEIDKEFADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQC7</accession>
    <name>A0A8G1QQC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-containing monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_464520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825095">
        <property type="protein sequence ID" value="RAH51708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509630.1">
        <property type="nucleotide sequence ID" value="XM_025661989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQC7"/>
    <dbReference type="GeneID" id="37165391"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH51708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="594" mass="65479" checksum="D5DABFDF8E4F8A54" modified="2022-01-19" version="1">MANLPQGILPTLPCALPKADLTIDSDAVGIAKGLSIPLNSLSLEQFTSDALWRDTFALTGTLRTLYSAVTVFKAWDQRCLARQAKGFRLNPDAARAVCPAPGIGWIEVPFTFETAAIPATTCSGFVSLVPNENGSWKIWLLRTILDQFQNLPNVDELKPGPAPTRHRLHEGAAYECVVIGCGQSGLSVAGRLQALGTSYLVVDKAPRVGDSWLQRYESMKLHSVRDAAQLPFDRTFTEDYPEFMGREDLARGYQAWAERYCINISFSTELTSGAWDDNKRKWTLHLRLKQNEQVTTRTITCSHVVMAIGAGGQEPVRPTYPGEDIFQGEVIHTAQYKSPRSWQGKHGVIIGSANSAHDTAADMVGIGMASITMVQRSRTCIASGIIPKEFMPQRAQGTLAADKQQLSTPLAVSRLMSTLTLRSKIARNPERFDALERAGFKVDRGAEVVAHVHERYGGHYMDVGNCANIAKGLVKVKSDSPLVRFTSTGLLFEDNTHIPADVVVFATGYKWNARDTVGELFGKEVHDRVEDYWGLDKEGEVRGAFKPSPHGHIWFISGTTTHSRYFSRFIALLIKADIMGVPIEVYRGIPDADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQQ7</accession>
    <name>A0A8G1QQQ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_524636</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510000.1">
        <property type="nucleotide sequence ID" value="XM_025665428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQQ7"/>
    <dbReference type="GeneID" id="37168830"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000023">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF7">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH52078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="498" mass="53801" checksum="AD10B4311FE40672" modified="2022-01-19" version="1">MALYELPFQLSDPSILHFDAFVNNTWIKSQSNQHFEVIDPGTSHPWAQIPTCTTLDVPDAVTSAHTAFLTFRHTTARYRSELLTAWDTLIRAHKTDLAKIITYETGKPLAEALGEIDYATSFTRWFSGEAERVSGTISSSAVPGRRVMTIKQPIGVAAALVPWNFPVAMVLRKVAAAIAAGCTMIVKPSPESPVSALAIAGLAMQAGFPAGVVNVLTTDMENTPSLSEALCRHELVKKVTFTGSTRVGKLIAGICADGLKKVTLELGGNCPFIVFEDADLEAAVAALMNLKWRHAGQACITANRVYVQRGVYERFAGLLRERTEKLVVGHGMEDGVGMGPLTTERGVGKAELQIEDARRLGAEVILGGGRVEGKKGYFFQPTILTGMTKEMLVSREETFAPVAALYAFDTEDEAVQWANDTSMGLASYAFTKDADRLWRLFEKLEAGMVGLNTGSMSAAEAPFGGMKESGYGKESGKDVAVDEYLVTKTGTLTVQGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS24</accession>
    <name>A0A8G1QS24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinetochore protein Mis14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_406393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511183.1">
        <property type="nucleotide sequence ID" value="XM_025657332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QS24"/>
    <dbReference type="GeneID" id="37160734"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013950">
        <property type="entry name" value="Mis14/Nsl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749:SF3">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08641">
        <property type="entry name" value="Mis14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="281" mass="31062" checksum="C4C3CB1EAC9447B8" modified="2022-01-19" version="1">MSTDHHRKIELQSPADFTYLYANTVALSRAKLDLHLPPSANPNDGPDPMRERVRELVDEYINRTFNSASPSISINGLDSTSPEWPFPAAFTAPTEQVEYEAYDGKLASRVTSLYAQLESLTTTVAQLRRDAPGRAAKAYAEQLRRALREDEEEEKLEDLEGEEEMKEEEEEQSTGQDTEMADAGATSTTTATQRKGPMTRSRAKLEISLGTENEAERWRSGEMAEVYEDALRTLLRLQGEGVSVDTSGDGTDGNALSSTLGKAERAGRAVEVVEKKGEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSJ3</accession>
    <name>A0A8G1QSJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ochratoxinase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Amidohydrolase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Carboxypeptidase Am2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_406617</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Carboxypeptidase that catalyzes the release of a C-terminal amino acid with specific catalytic activity for aromatic amino acids such as phenylalanine. Is able to degrade ochratoxin A, one of the five major mycotoxins most harmful to humans and animals that is produced by Aspergillus and Penicillium species and occurs in a wide range of agricultural products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ochratoxin A + H2O = ochratoxin alpha + L-phenylalanine</text>
            <dbReference type="Rhea" id="RHEA:72751"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:166829"/>
            <dbReference type="ChEBI" id="CHEBI:192527"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:72752"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the metallo-dependent hydrolases superfamily. Ochratoxinase amidase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510990.1">
        <property type="nucleotide sequence ID" value="XM_025657338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSJ3"/>
    <dbReference type="GeneID" id="37160740"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000068">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="17">
        <location>
            <begin position="102"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH53068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="480" mass="51362" checksum="9C8428206F13810D" modified="2022-01-19" version="1">MVRRIVPITPMAQSPMSPLGATYCVRPNSVSMNIHRRPLVLASTDEAKVTIIYAGLLIPGDGEPLRNAALVISDKIIAFVGPEADIPKKYLRSTQSTHRVPVLMPGLWDCHMHFGGDDDYYNDYTSGLATHPASSGARLARGCWEGLQNGYTSYRDLAGYGCEVAKAIDDGTIVGPNVYSSGAALSQTAGHGDIFALPAGEVLGNYGVTNPRPGYWGAGQLCIADGVEEVRRAVRLQLRRGAKVIKVMASGGVMSRDDNPNFAQFSPEELKVIVEEAARQNRIVSAHVHGKAGIMAAIKAGCKSLEHVSYADEEVWELMKEKGILYVATRSVIEIFLASNGEGLVKESWAKLQALADSHLKAYQGAIKAGVTIALGTDTAPGGPTALELQFAVERGGMTPLEAIKAATANAPLSVGPQAPLTGQLREGYEADVIALEENPLEDIRVFQEPRVITHVWKGGKLFKGPGIGPWGEDARNPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT50</accession>
    <name>A0A8G1QT50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">DNA polymerase</fullName>
            <ecNumber evidence="21">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">BO85DRAFT_429588</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Catalytic component of DNA polymerase delta (DNA polymerase III) which participates in chromosomal DNA replication. Required during synthesis of the lagging DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork. Participates in leading strand synthesis during replication initiation and termination. Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 21">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 21">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="21"/>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511305.1">
        <property type="nucleotide sequence ID" value="XM_025658254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT50"/>
    <dbReference type="GeneID" id="37161656"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.730:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000009">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 21" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 21" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 21" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 21" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 21" id="KW-0408">Iron</keyword>
    <keyword evidence="16 21" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18 21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 21" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 21" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="24">
        <location>
            <begin position="244"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="23">
        <location>
            <begin position="539"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="25">
        <location>
            <begin position="1007"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00055225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="RAH53383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1105" mass="124848" checksum="923D076F265AA269" modified="2022-01-19" version="1">MPEAVAMPQKRVLGDASNNPRGVATDPSALKKRRIENGPAATMKPPTNGQRRVPGSSQPQKSQFEAEVLEKLTQDINGLKDSNSEKDQQWERPPLGEFDPSTENICFQQIDAEEGTIMGGKTAVRLFGVTEAGQSVLLHVTGFQHYLYIAAPVNFTKDDCEPYRAFLESRVGQFQPTIQSVQITMRENIYGFQGNQKSYYLKITVTDPKFISKVRSALEQGGAQSLNYKGLWNNSDGGILTFDSIQYLLRFMIDTDISGMSWVEAKAGKYRLFQQHEKVSNCQIEASVDYRDLISHPPNGEWAKMAPLRILSFDIECAGRKGIFPEPNHDPVIQIANVVTRYGESKPFIRNVFVLDTCSLIVNTQILEFKDEAKMLMAWREFVQKVDPDVIIGYNIANFDFPYLLDRAKHLKCTGFPYWTRLNGVQSQSKETNFSSKQMGNRDTKSTNTNGRIQLDMLQLVQRDYHLRSYTLNSVSYEFLGEQKEDVHHTMITELYNGTPDSRRRLAVYCLKDAYLPQRLMDKLMCLVNYTEMARVTGVPFNFLLSRGQQVKFISQLFRKALEQQLVIPNTKSNDEQDYEGATVIEPVRGYYGVPIATLDFASLYPSIIQAHNLCYTTLLNKNSVERLKLVKDEDYIVTPNGDMFCTAKVRKGLLSQILEELLSARKRAKKELATETDPFKKAVLNGRQLALKISANSVYGLTGATVGKLPCLPIASSTTSYGRQMIEKTKQEVEARYTIANGYSHDAKVIYGDTDSVMVKFGVDNLEEAMKLGQEASEYVSSKFLKPIKLEFEKVYFPYLLINKKRYAGLYWTNPNKYDKMDTKGIETVRRDNCLLVQNVIETVLQKILVERDIDGAQDYVKDTISDLLQNKIDMSKLVITKALSKDAYTAKQAHVELAERMRKRDAGSAPTLGDRVAYVIIKGAGGSKNYERSEDPIYVLENNIPIDTKYYLDNQLANPLGRIFEPILGEKKASQLLTGEHTRAISVAAPTMGGLMKFAKKTQTCLGCKKPLSGKEEAEGAVCAYCRPRLGELYTKSLTKVSDLEVRFGRLWTQCQRCQGSLHCEVICSSRDCPIFYMRMKAKKDVEDAQKELSRFDNDAGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT56</accession>
    <name>A0A8G1QT56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 Z</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin carrier protein Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_454582</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="KZ825093">
        <property type="protein sequence ID" value="RAH51810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509732.1">
        <property type="nucleotide sequence ID" value="XM_025661322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT56"/>
    <dbReference type="GeneID" id="37164724"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23809">
        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="290"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH51810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="444" mass="51316" checksum="5D6C2F22BEE891FD" modified="2022-01-19" version="1">MSDQAILRITREIKQIQQGADHSLAVYYDDSDIRSVRALILGPPDTPYQFGFFEFLVKFGKDYPATSPNVRALTTNGGRSRFNPNIYSSGRVCLSILGTWRGESGEQWSSAQCLESLLISIQSLMSSNPYENEPGYESSRSPSDIENMEAYVSKIHHETLRLAVLEPLEASLNITLEGSTDSLADPSSESDDNIIYEDGRPSFDPFADFRKRRFLWYYEPYMQSLVAAEKKHSRKAKFQRMPFEGDNNSMDGHFDYPELKRRMAVVRDAILRETRGWAVEGQLAKKQEWGIAASLQRQYEQIVETLKHQNNITVDLYLDEGNPFMWRLTYFGRPMTQLDGGMFKILIHLSPRFPEEQPRVFLEASSFFHIRVSKEGVLCYVPRRTEEMRYHIEGIVAALEEEHPPYDPRTTVNPEATKLFWGTPEDRRKYNRELRRSVERTAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT83</accession>
    <name>A0A8G1QT83_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BO85DRAFT_462524</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511783.1">
        <property type="nucleotide sequence ID" value="XM_025661854.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37165256"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:Smc5-Smc6 complex"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:chromosome organization"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="RecF/RecN/SMC_N"/>
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        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
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    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00270">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="1024"/>
            <end position="1052"/>
        </location>
    </feature>
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        <location>
            <begin position="1055"/>
            <end position="1225"/>
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            <begin position="1219"/>
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        <location>
            <begin position="805"/>
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            <begin position="1024"/>
            <end position="1052"/>
        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="1411"/>
            <end position="1422"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1427"/>
            <end position="1450"/>
        </location>
    </feature>
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        </source>
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    <sequence length="1450" mass="164774" checksum="863646D887ADDA42" modified="2022-01-19" version="1">MCHDHFYVDLGPLINFIVGKNGSGKSAVLTAITLCLGGKASTTNRGQSLKSFIKEGKEHATIVVRIKNQGDGAYMPDDYGKFITIERHFSRNGTSGFKIRSENGRIMSTKKSELDAIIDYFTLQFDNPVNVLSQDMARQFIGSSSPSEKYKFFVKGVQLEQLDQDYRLIEESGDQIEEKLRGREQDIAILQSRKETAKRKLDISNQHDSLRNRIRNVRNQMAWAQVEEQERIRDSLDEELLAADNQIAADEADLTNFDGTINAAAAELEAAAGSVRQANAKRGQVQGEKDEIQARWDAQMTERHGLQAEQRRIREYLKAAEERIATTQRSIDEENRRLAEISGGSFTRKQEELERAKEEASQARAQYEEHSSDRDRLFHDINEAEEKVREAEGPVDKIRADVKEAESLLSTLKREGGPQNSGFHERMPFLLRAIEQERSFTNRPVGPLGHYVRLLKPEWSSILENAFGTTLNSFVVTSPRDSKILFQIMRKVNCDKHINTSGNEPDSQYDTALRVLEFDNEWVRGQLIINHHIEKMLLIENLEEASSVLFDGQQPRNVKRCYCIDQTNRRRGIHLSFSRTGEPSQAPVPAYKGSPRMRSDRESQIKVQQSVVADLKQDLSRHEQELRSARSRLESCKQARQKHDRRSNELRIAAQRMEDRVEELKDALDREAPEDGRLDGLRTTLQEAEEERHLNEGSLNDATDAMEGLMKELKAIKQELAAKDAEIAIVQEELKVAQDAERKADEERRKRINDKNAAAERIEDRKRDRDRVKNKRDEIAVRIVDFSEKANIICDRVAIEEGETAASLDRKLERLHNDIKRYEQQLGASRDELLAEVTKASEAYDRALKQVLKATLNVRKNRWLIFRSHISSRAKVEPDITKDSAGRGAKTLSGGEKSFSQVCLLLALWEAMGSPIRCLDEFDVYMDHINRKMAIDMLMLAARRSIGRQFILITPGSRSEITLAPDVCVKEYYFYSYHFPREITQANVFQAWIELVIITWKEQLNVPAKDARPQTEDVTATKGLEFEDFYIKRELMMGIFEAGFEKPSPIQEETIPVALTGRDILARAKNGTGKTAAFVIPTLERINPKSTKTQALILVPTRELALQTSHVCKTLGKHLGINVMVTTGGTGLMDDIIRLNDAVHILVGTPGRVLDLASKGVADLSECPTFVMDEADKLLSPEFTPVIEQLLSFHPKDRQVMLFSATFPLIVKSFKKVHCLNTLFSKLQINQSIIFCNSTNRVELLAKKITELGYSCFYSHARMLQQHRNRVFHDFRNGVCRNLVCSDLLTRGIDIQAVNVVINFDFPKNAETYLHRIGRSGRFGHLGLAINLINWEDRFNLYKIEQELGTEIQPIPQNIDKKLYVYDSPDTIPRPIANPSQPQITAQAANANIGERRHNHHMNGGQYQYGRGRGSYRGGRGQGQRRNMQNETKFGTQGQSSGKSHPTQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTA0</accession>
    <name>A0A8G1QTA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase, PLC-D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_453346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025661030.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
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        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
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        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034802300" evidence="2">
        <location>
            <begin position="18"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="RAH53253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="467" mass="53879" checksum="ACA661A73D5948AD" modified="2022-01-19" version="1">MKLNVAAISVLATVASALPHKRNSDQWGHIRSNIKHVIYLMMENHSFDNIAGYWDFHPDIDNLRNISYCNEYTNPNWTVWDEPLNVCAAPFETEVPLTDPDHNFAGVTYEIFRKWYPTKDDVPNMGGFIERQSEKYAASPGESSFVIKAYDEKKTATLIEIAKNFAFWDSYFAEHPGPTNTNRQFATSGSTCGFVDNTYQSAGWYANYTGTTCATSIFEALSKKNITWKNYYETDIVDAYMYKWVQDNAMDRLVHSDQFYRDLEEGTLPQFSYYNPECCTIDSMHPTSNMASGEQLIKHLYDAVRKSKYWDNVLIILNFDEHGGFADHVPTPVNVPQPEDGITFTGMSDGHNVTYDFTRLGVRVPSFVISPYIPANHLIHDQGTMYANNSAYTHTSFLHFLQELWGLEGLNNRVQWAKTFEYIFSSEKRDDTPEKLTTPTWYGSSWEPKPDPYYKLNQDYDYYENLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTM7</accession>
    <name>A0A8G1QTM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_504652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511294.1">
        <property type="nucleotide sequence ID" value="XM_025664308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTM7"/>
    <dbReference type="GeneID" id="37167710"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="357"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH53372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="701" mass="77776" checksum="40182E8B3C511691" modified="2022-01-19" version="1">MHSRDTICALRLPVELIEQIVGYLECANHINALARTHRNFYRAVNPMLYRHNVHHNNSSALAWGIEHRCLATVQKSLEAGASANECDPDTLWRPMALAVIEGDEAIVRYLYDQGGVDIRHTRRWLNPRHEAYDKSPGSLLLLAAVHGHEALARFFMDHLPRPYHVDYPADSDGRTPLMEAAAGGHLAIVQWLVDAGANIHARDHESWTPLVLSARGGHLEVMRFLLQRGADPTISTVPDGCSALCWAARLSRFECVRGLLDAGVMDQLTRCQGSESPSSHNATMCPLTSNTLLKCDIIVDLLFERWDYLASTVEPANKAALLCVAAARGNTALVRQLLECHGYDPNSRCGQVFIWDDLPTALCWAVVRGHTEVVQVLLAHGAEASPSPGGMPMVSMLLSAGADPNDQDAQDGYPALRHAIPFEGIFRHLLAAGADPIAVDRPGDTLPAIVLASGRTALVQMLIDKEIDPPCHMGLANFLHQAIRGGAAVLDLLVRTGRWNSYIFPEHLNKTACEQALVIAASTGKIETLQWLLDRGFSVAHLSPTVNLIAEAACTAASDVDAAETIDLLLQHGLDINKRIHERIDRKTALAHVAYHYNLHTDNDTGRVRLRMLVDRGAHLLPPRSPSERYNPYTSTTAVCVGVSSVLDEMIFQEMEARREPWIAVEWLFKYAELDARDRWDWEGVKMIKRYSWRVRYPVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QU60</accession>
    <name>A0A8G1QU60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_453553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510824.1">
        <property type="nucleotide sequence ID" value="XM_025661077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QU60"/>
    <dbReference type="GeneID" id="37164479"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="2">
        <location>
            <begin position="138"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="256" mass="28627" checksum="31008D20382F7762" modified="2022-01-19" version="1">MDAPCLAIRSPLLRRCHVCLSGPRIPDASRLTRPRAVTPFIRRSSTRRYATVQDTQADSLNDSKSRQAHPLSGYYYDILSTRSPYRHHATTDTKTEEPKPEAQTPQEKMAIVFGTRLAGPGRSSRYDPGSAPDKTWKTINGVAIPPRPEEPDNCCMSGCVHCVWDDFRDELEDWAFRLEQAKAKGASKSDASDMRHTPRAEVRSASMSMDDDGGGSETNWSAPTSDDDLFASIPVGIREFMKTEKKLKQRHQQESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUU9</accession>
    <name>A0A8G1QUU9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Caffeine resistance protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_428206</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512190.1">
        <property type="nucleotide sequence ID" value="XM_025658199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUU9"/>
    <dbReference type="GeneID" id="37161601"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="120"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH54268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="538" mass="60450" checksum="F462FB735174054D" modified="2022-01-19" version="1">METIRDSAFGKLVRIFSRKRWLRYPEENDTGMWTEYLKTEKQVKDEEAAASESDHENLGLYTVLSQASRASRRLSTASTARHDGAEGAHPNSNASLVIDWSGPDDPENPQNWSTFKKLFVSSLIWLLTFAIYIGSAIYTPGIPGVSEQFGVSSVAATLGLTLFVLGYGLGPMVWSPLSELPPVGRSPTYVLTLFVFVFFQFAVIYATNFGMLLAFRFLTGFIGSPALATGAASMGDIWNPKMRDYMIIIWGAFAISAPVLGPLVGGFAAQAEGWKWTIWQLLWVSGFALVLLFFFLPETFAPNILYRRARRVRQITGNSNYRCEAEIEVANMRKMDIIFEALVRPFELCFFEPIVLIMNLYIALIYGILYIWFEAFPIIFSEIHGFNTGQSGLAFLGILISTCAITIPCYFWWKWKYQAKHFDENWNITPERQLPPACVGCFALPISLFWFGWTGQFASVHWIVPIIASMLFAVGGCLIFNCIFCYQAHAYPKYAASVLAGNDFLRSSFGAGFPLFATAMFHNLGVGWAFWEEVEDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVQ5</accession>
    <name>A0A8G1QVQ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_153581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511411.1">
        <property type="nucleotide sequence ID" value="XM_025654164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVQ5"/>
    <dbReference type="GeneID" id="37157566"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="145" mass="16211" checksum="883EBAEA8A85AB91" modified="2022-01-19" version="1">MPKSIEMVLGTYYATCSCAPALFCVYSPSLHHRICRDARSPSCSYVKEMASKFHLGIGCPMVGQHVIVWILEPGKRFREASSRDAFHVIGTLSNNITPGKAWERRSSQGVEVATTFIPSMFVSTRPTCRCVLKRDRVSSCRFVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWN9</accession>
    <name>A0A8G1QWN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein Pth11-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_381526</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511472.1">
        <property type="nucleotide sequence ID" value="XM_025656426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWN9"/>
    <dbReference type="GeneID" id="37159828"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="45"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH53550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="407" mass="44483" checksum="AFCDC39675195799" modified="2022-01-19" version="1">MAVDPAIVAIFGEPPDNIDLTDSRVQQDNAVVIFILCLAVISVVLRFVARRVLRNSLMMDDWVIILALMFICTTSGLSISGGFFGAGKHVWAISVTKLMALFRVSSTTHSTVARALTFQILYIYVMVYSAVCAASKVSILFFYRRVFMASHADLSLRIGIYLGFFLTLSYPIIICVTMATACKPASYFWDQFGGASGTCIDTDTFFLALGIINMLNDIVVLLIPFPQIAKLQMNRRKKVAISGILAVGSFACVASIVRIYSVDEFTKRNDVTWTLGPVFIWSTIEPGLSIVCACLPHLAPLVRLAHIKLSSSQDSKPTHPSTPWRSRSGIANGGGTPSAGRRVHSVLSTKYTFDGQDDEEIGLTNHVTTSTSLRKPHSMESVEREGGSTADQSIMVHSSFEQSVSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWZ0</accession>
    <name>A0A8G1QWZ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HSF-type DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_167712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510822.1">
        <property type="nucleotide sequence ID" value="XM_025654267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWZ0"/>
    <dbReference type="GeneID" id="37157669"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000229">
        <property type="entry name" value="HSF-type DNA-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF396">
        <property type="entry name" value="FLOCCULATION SUPPRESSION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="576" mass="63015" checksum="354CB37731FC8595" modified="2022-01-19" version="1">MSGLADPPSRSPLILTAIDAPGKTRKIPVLASSVPPSSQSTGDPMEVTPPASGAAPPIHSSPDSDRAGASNTTATSNGSTEPSNVNHHAAPTQAIGAAAAAQQPKVVQTAFIHKLYNMLEDPSIQHLISWSSTNDSFVMSPTSEFSKVLAQYFKHTNISSFVRQLNMYGFHKVSDVFHTGSPDSALWEFKHGNGNFKRGDLVGLREIKRRASRHALIHRDSFPGHKAAASQPGTPAEPVPDVTESRLMNLEHSMYDLHARLRNAEEGNATLNARCQSMAESLTRCYHWTHSISRFLQGMIPDRESLLYRDVASMQAELEKHLEAVRALEHPPDPYLAVRQPYVTGISGDAGPPLSPRQMPPEESRRPSMLDPSRTGMIRPPVPPHLAVSPRRYGSIGAGNSSPSYNRPQVPAVVTPQQPMPHPLSSVSSPPGPNLARRHTSADIRQHGWPPPGVSPFPSAHPPQPTNPWSPSRHRTPTSSEQSVRDVLAQYEMGAPRRLQEHRHPTPPLHPDQNPPTDNGWSLGPRFPRHESSLPATRRSSMASNVHSLLNPADTAERPDEDQHAMADDRKRKRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX07</accession>
    <name>A0A8G1QX07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_70186</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513883.1">
        <property type="nucleotide sequence ID" value="XM_025665602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX07"/>
    <dbReference type="GeneID" id="37169004"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034277925" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="20"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="88"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="112"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH55961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="233" mass="21198" checksum="425897C5ECAE01EE" modified="2022-01-19" version="1">MKTFSLSLALLAAASMVSADVSVSDCAQMCLSNMNNKASELGCSSGDMSCLCSKPDYSYGIRDCTAQACPNDDANAVVSTALASCPTSSGSSDSASATGASSTGSGAGGAGSTTSASSATGSGASSASGTNSGNTSGATTGATTSGATTLSTITGTSTSTGTVSGATSGSSGSSTSGSGSGSGSGSSSNGSGGSSSATGTAPSSSETTGAAPKLNIAGSGIAGALGLAAMFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX98</accession>
    <name>A0A8G1QX98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_479042</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514018.1">
        <property type="nucleotide sequence ID" value="XM_025662927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX98"/>
    <dbReference type="GeneID" id="37166329"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF129">
        <property type="entry name" value="ASPYRIDONES CLUSTER REGULATOR APDR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="44"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="106"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="624"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH56096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="789" mass="87164" checksum="D237484859B26F2A" modified="2022-01-19" version="1">MTDTEPRKRRRPAKSCEQCRQRKVRCDRNVPCGPCTRARSSLGCSYRRVSRSPSPTDHQASPLISHEPQRNARGHPLPSGMPDGSTVSLDETPHIGPQCGSKECFSSQLGSTIRDLQLRLQRLEEQLTSPDIARPEPDIQQALRELCDKVQSLEQRLLRTQSSQAPKGELAIAAAPPRLHSSSKKMKLFGPTHYMHTMDKLQLVGSMETRGPQPLCPELKAELTAQIKELRYLRGSVKAAQSPRLNDPVPDLLSTIPTRSVCDELVQCYLRTFESIYRIVHIPSFNKEYQQFWDHPPTTPTPFLMKLALILAIGTIFHPQRGKAGKEYDTRLIQTWIYAAQWWLTGPTEKNTFNLDGLQIFCLLLLARQLGSPGPSLYLSAASLLQTATAMGLHRDSAHFPSLSPFQSEMRARIWTTVLELTLQSSLESASPIPIPYFDTKPPSNLNDTDIHPDLKHSPTPHPSTTTHTDTSLQLLLHDSFTLRAETIHLIHSPNNIPYQKALDLTTKLRTTCHTITTTTTSPQSFHHSHLLTTLTRYILHLHLPFARAAHITPQYHYSRKLCLESALTIASFAPTTTSFTPLDNDFPLLTLTARGPLRGPLNLDVICTLALELITQIEEAPDTTNNPNNHNNNSTSTSSRPSPLFLLSSTIRTPILHTLENLALQSAHVLKMHGKSPALKRYIISQALVAQIRALEDGAGAGDDVQGVVYEAVRGCLRDGVGMLRGMEKEGIAEGLGMFVTPDSASASAGAGAGAGGLDEMEEGLGIGMGLDDLEGWDLASFFMMLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYS1</accession>
    <name>A0A8G1QYS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_490827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512552.1">
        <property type="nucleotide sequence ID" value="XM_025663680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYS1"/>
    <dbReference type="GeneID" id="37167082"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="85"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH54630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="227" mass="23956" checksum="B5F1FCC79069BC62" modified="2022-01-19" version="1">MSPTNRVPSMRMNPSGARDIPTFIDELAKDEAKNQPRGDSESTFSGASTLQGNEQSSKLKRGLFSILNSSKSLNSGTMPSLADKVQTAQVTLGYTFDNPNIGMGALVTPGVALPGLPTRMDGHKELAHVGDAVLKLALTLDGYEAKRSREFTSKILQTKASNVNLALVGRRMGLDKLVIVNPSQAGIVSDKVMANTVEALIGAVYMDSNSIDAVRPVLAAMGLDGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYV9</accession>
    <name>A0A8G1QYV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_469903</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514024.1">
        <property type="nucleotide sequence ID" value="XM_025662358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYV9"/>
    <dbReference type="GeneID" id="37165760"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.20:FF:000002">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1280.20:FF:000004">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="600"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="713"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="812"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="824"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="844"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH56102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="857" mass="95115" checksum="948F63D84A93930D" modified="2022-01-19" version="1">MPISPSSARPPPLSSERRNWRRLSGLSVVSPIHERPTPENGQPSAITEEISEIKRYEDFTTIDWVQDAVHEQARRRAKRRDGSGFWDQEGTFGWRRKVRESYDAGQAWLVITIVGAAIGLISAILNIITEWLSDVKLGHCTTAFYLNEQFCCWGAEGGCPEWRPWTSYWIVNYFIYIFYAVLFAFVAASLVKSFAPYAAGSGISEIKCIIAGFVMKGFLGAWTLLIKSIALPLAIASGLSVGKEGPSVHFAVCTGNVISRFFSKYKQNASKTREVLTATAAAGVAVAFGSPIGGVLFSLEEVASYFPLKTLWRSYFCALVATGVLAVMNPFRTGQLVMFQVQYDRTWHFFELIFFVVIGVFGGLYGAFVIKWNLRVQAFRKKYLSQHAVMESVVLALITAILCYPNMFLKINMTEMMEILFRECEGGHDYNGLCEAKNRWSMVMSLAVATILRIFLVIISYGCKVPAGIFVPSMAIGASFGRFVGILVQALHEAYPKSQFFASCEPDIPCITPGTYAFLGAGAALSGIMHLTISVTVIMFELTGALNYILPTMIVVGVTKAVSDCFGKGGIADRMIWSNGFPFLDNKEDHVFNVPVSQAMTSDPVSLPASDFPVREAEHLLSDNKYQGFPIVDDRTRKTLVGYIGRTELRYAINRAKAEGPLSPTAKCLFTKEAAEASVTRRASTASHLHAPETFDDIQTNTGADYVDFSRYADHTPLTVHPRLALETVMEIFKKMGPRVILVEHRGRLMGLVTVKDCLKYQFKVEAEEQALAATSPPQLALGGSNGRSSGDTLEERLWNLLQRIGSILPWQHTQPQQQQQPPRRRDTTVPEQHRDATDIAPNEADETDAMLELEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZJ9</accession>
    <name>A0A8G1QZJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_523046</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512127.1">
        <property type="nucleotide sequence ID" value="XM_025665313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZJ9"/>
    <dbReference type="GeneID" id="37168715"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF71">
        <property type="entry name" value="OXIDOREDUCTASE TPCJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="133"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="244"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="538"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH54205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="671" mass="75464" checksum="16EED79207125325" modified="2022-01-19" version="1">MYLQTYLIAIITYFGFPSFHGSQQPSLQYPLQLDNADLTPPAPKDLSFIPPGAAEETLGEPFRCQYPSMAADYTYNPTPENRSIWLKHRTNSSLDFDINTDYETRWPAGIERKYILTVGERSLNLDGIEFPYAKVFNNSYPGPWIQACWGDWINITVKNNLRRNGTAIHMHGLRMLSNGLMDGVPGVTQCPIAPGDTFNYMFNTTQYGTTWYHSHYSLQYSDGVLGPLTIHGPTSANFDKAIDPIIFTDHNHQSAFQLYYQEQFANNSTRVPPKQTSILLNGHGSYAGSFPERRYHKKVQPGKKYILRLINGSTDTTFIFSIDGHNLTVVGMDLVPVQPYTTDHIYVGIGQRYHILLETKTDFSDSMNMAYWIRTDPATGCHNFETIPDARQGILWYGGSSHPPIPTTNAHAYNNTCSDMLDLVPVVPWTIEEPPPIIPMVRYTMAQSSIETMSVTIGQWNLSAVGDDPEVTVNFWQFLNDTLWVNYAEPTVNHLDPPYNSSAVIYLAAEAQPAQTTWNYMLIIGGNIVATPPVTGGNLAPNAHPIHLHGHDFAVLQYSTDKYNSSEDLDLNLENPRRRDAVLLPQNGFIVIAFKTDNPGSWTLHCHIAWHASAGLAFQVLEEQPAFKAGIEDSTVARIQLDRTCQNWDVWFANASNHWNPNGRFQDDSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZT6</accession>
    <name>A0A8G1QZT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_460998</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513824.1">
        <property type="nucleotide sequence ID" value="XM_025661751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZT6"/>
    <dbReference type="GeneID" id="37165153"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000145">
        <property type="entry name" value="Putative RNP domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000232">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000280">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="107"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="223"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="383"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH55902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="487" mass="52010" checksum="7B7EF77B92A63CAD" modified="2022-01-19" version="1">MSPSAFDDTDHAQRERSRSPRRRSRSPRRSRRSYSPRSRSRSRDDYRRSDRRSRSPMSTTQGAPGGHSASGYGGRSSYPPPPRSFEDRAVAKEQMMQAVRESSQQDRRVYVGNLSYDVKWHHLKDFMRQAGEVIFADVLLLPNGMSKVGANAIVEYATREQAQNAVNTLSNQNLMGRLVYVREDREPEPRFTGGPSRGDFGGGGRGGFGGGFGGPAGGGAGGRQLYVSNLPFNVGWQDLKDLFRQAAQQGAVIRADVHTDATGRPKGSGIVAFESPEDARNAIQQFNGYDWQGRQLEVREDRFAGAGPGFGGRGGFGGRGGFGGGFGGRGGFGGRGGFGGGFRGGYGGAPGGFGGAPGGFEGVPSGPPNPFTDFATSGGDKSAVIYVRNLPWSTCNEDLVDLFSTIGKVDRAEIQYEPNGRSRGTGVVQFDSTETAETAIAKFTGYQYGGRPLGITFVKYMNAGPGPGDVAMDGTEPTAPITQDQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZY4</accession>
    <name>A0A8G1QZY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_422803</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514751.1">
        <property type="nucleotide sequence ID" value="XM_025657988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZY4"/>
    <dbReference type="GeneID" id="37161390"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF11">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G06590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0697">Rotamase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="345"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="673"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="744"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH56829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="916" mass="101744" checksum="7F986868E2D7FA74" modified="2022-01-19" version="1" fragment="single">MGRTPGKRSFEQVDLTTDEAVNNTRHHPTPRTTSGQRFGQDTSFVPLSQSGEDEDDAHATDLIQGSQDAGDDVSTYIHYGDLKAKIVGVRYYRGHATIGEHVRVVRDPGNPYDSNAIRVDNVMGQQIGHIPRTVAAKLAKYLDDRSLVVDGVLTGVIGAFDCPIVLKLFGTSQPEARQALKSRMEMDNLPLGGFKRNERNEKKLEKEREKARKEAAKLARSLAKGKGKQFQGENVLGYSNLFTGEGLVEGENLEELIGQSSTFNPRDIGHVAEDFGMKESDLENMPMAESPAALATELLPYQRQGLAWMIAKENPGLPGDGGDVVQLWKKNGNKYTNIATNYSMTQAPPLASGGILADDMGLGKTIQILSLILVNSQPKTPESSRTTLIVAPVGVMSNWRNQALVHTHSDKAPKVLIYHGQGKKEASNLDQYDVVVTSYGALAMEYSPNAKAPPKKGLFSLHWRRVVLDEGHTIRNPRSKGALAACNLRAGSRWTLTGTPIVNTLKDLYSQVRYLRLTGGLEDLAVFNSVLIRPLLSGDPDSRLLLQALMTTICLRRRKDMNFVNLRLPPLTSRILRIKFHPHEQEKYDMFQSEAKGMLLDFKSKDKTSTNYSHLLEVILRLRQVCNHWALCKNRLDKLANLLENNKVVPLTPENIKALQDMLQIRIESQDTCPICLDNLEQPVITACAHAFDRSCIEQVIERQHKCPMCRAEIPDTTTLVSPAVEMGESTDTVDADPDNPSSKIEALIKILTAQGQASGTKTVIFSQWTSFLNLIEPHLLRHGIGFARIDGKMSSISRDNSTLRFSTDPSCTVLLASLSVCSVGLNLVAANQAILCDSWWAPAIEDQAVDRVYRLGQTRETTVWRLVMEDSIEDRVLAIQENKRKLMLEAFRETATRKKVDDRATRVADLEKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R063</accession>
    <name>A0A8G1R063_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_489614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514143.1">
        <property type="nucleotide sequence ID" value="XM_025663614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R063"/>
    <dbReference type="GeneID" id="37167016"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="170" mass="19060" checksum="78D34F4BEB521C7E" modified="2022-01-19" version="1">MGGVTGHREHTGIKPTVPAIPSSSYELFSYSLPIAYRAGQTDVVGYSDTIILVEASTASEPRQPIRPANISYSAWLDFLKSDCEYNSLTEDVYMRDDQQPFARMINTLNRLRYMLLKTQGPVCRFEIQSKSHPHPSQSNPAGLFSIRDTWPAMRRGPPEPDSGKGRGKPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0D1</accession>
    <name>A0A8G1R0D1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_450849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025660469.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="37163871"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH56202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="245" mass="26190" checksum="4238990B9FEBD3DB" modified="2022-01-19" version="1">MATKPFAIIAGVGPGTGASIARRFAKSYPIVVLARNPANYQPVVDEINSAGGQATGISADLSDTTGVRSAFEQIKSQFQGSSLAAAVFNSGGGFVRKPFLELTETDFASGFESQGKGAFNFAQNVLPLFPAESQGGLKYPPTLIFTGATASLKGSAQFASFAAGKFALRALAQSLAREFGPKGIHVSHVIIDGVIDIPRTKGWVFEKEDAKLDPEAIADSYWHLHTQPRTTFGFELDLRPYVERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0N8</accession>
    <name>A0A8G1R0N8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_438143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515833.1">
        <property type="nucleotide sequence ID" value="XM_025658657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0N8"/>
    <dbReference type="GeneID" id="37162059"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="395" mass="45106" checksum="2AE8335270FE7A9E" modified="2022-01-19" version="1">MNYTTNKLCTLALAHWVPRQNQTDTPEAMTMSLYIHDINDATHPGRLSKNWSRLLRAGAKRFYFYANEEEIEVKADGSSICLLRRTCAARTYNVRSTNHWTRRLDHTQWANAFWNSVVCDVWTRPVLKAIQGAANMQRKINNLSTHLAAFTDELNPFLIAEATVKEAMALHPNDKAGKKTQSIVGNTHLSIVDAASMLCQSPIYLDSWKYTGLSDTTSNILQYQILGFLVDNPLQHLMSTRNRLIGKYGDEDSHDTSNIECVTDELQDSRPGLYKEVETVKRLGHLLPQELDNITLIYSETAHDILWNTIDYFAYTVIPTPGRDNPGFHPIHWLALLDIVDLPHQHDHCGKTEARESNMCTLYDVHFIALLTAISVRRDTRLKANSRLWYRNNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0U1</accession>
    <name>A0A8G1R0U1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_374879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514364.1">
        <property type="nucleotide sequence ID" value="XM_025656145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0U1"/>
    <dbReference type="GeneID" id="37159547"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="307" mass="35359" checksum="39AA5DE34B24B644" modified="2022-01-19" version="1">MLHATLPVSLKRSASSSLVCEAEPAQSTTRTTDPSISQRFYRSVECESRHETAEFPDQTLEESPAVPHQESLEHTRETALHTLALCRNVIASLEITRLSKSRTGLHYWLGFWDRIYGRQFSRLLSSRVTNTLARIDALFRAVSGDLHELTRRMQHAVTYATSEKEILRLLERMEDEVSVRRKRRRKKAQIIMNKLRASIEAVPIKVTDELFDDLKRGVFALDVFCDYHPGDPEAEEHERQALQPMNMVTVSPYLQPWHESAAAGAYMPLSAYTDIHPDWTEYAGDWMHRVDYRSRQPPPNNPAAHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1L1</accession>
    <name>A0A8G1R1L1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_439838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514052.1">
        <property type="nucleotide sequence ID" value="XM_025658732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1L1"/>
    <dbReference type="GeneID" id="37162134"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="382" mass="42760" checksum="3CC432C12547E2E6" modified="2022-01-19" version="1">MCQYTFHNNPDCGHIANFSLDICVDMMNTMREGTKNPPDHKVTTVHDLLPKGPFYQCRPCEGKLAKVDTNCSDCSDSEYVVLEGQNAGVPIVHSYMEMCLNEKNTPPDGCDNFVHVNQPPRLGTPTPAPKPMSASQTLKMRDLASSESEIHPPLNMMETLEGYEDFLKKSNEQLRARRPPSTPIRSPESGSYGDIPVANQSWYASDSDTETDQVQSPRPLGSPFSSPHRAPRPKEAPLRVSDLNSPPPSQQPGYLKATPRLTKAGIQGEAAPVYRSNGARTPPNQQWYSTLLPCTPSHLIIPQRYSPPSAPRKTHRTEYSQYNPVDTSGIPFRREYRLPRHDVLNTVLQSPPSQYPESYNRSYSRQYWGAVSGMSPACDERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R262</accession>
    <name>A0A8G1R262_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_32972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515054.1">
        <property type="nucleotide sequence ID" value="XM_025655434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R262"/>
    <dbReference type="GeneID" id="37158836"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="160" mass="18140" checksum="F2D214E1C14D5726" modified="2022-01-19" version="1">MQCSGKTSDNFHNRSYLRIVSLLSLSVVVDDQCTHLILHFIIIINRLILIGTLARKTKVNLDEQSAKQLGAKNKMKKKAESRKKTYTSRSADLRFPKVPVPTPLHPPFVDPRTSHLSSGSDTAKAAFHLSSSERTTTARVRIYCCQYTFNPDLQHVYHNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R293</accession>
    <name>A0A8G1R293_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DER1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_423022</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514846.1">
        <property type="nucleotide sequence ID" value="XM_025657999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R293"/>
    <dbReference type="GeneID" id="37161401"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF1">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH56924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="543" mass="61285" checksum="6D8BA8068E624266" modified="2022-01-19" version="1">MRLLLRSWQQQQQQQNWRTLPASCRACSSLSERLHRDLTSRQLPLTFDYLHPQPSYLLSLTLAELLPTLTPAPNELPSAHSRSPVPAGHHLVYFPPQVTLPQILPDGTDTLHAPGSPFDRRLWAGGSVRFSTPKGLVLNGSRAVCIETIRDVVMKGRSGEEKVMVKIERRIGTVQEGEDHRDIKERIWKETEEDVGDACVIETRNLLFMRKKTPEQLSHDKAGFDMENRAIKCASYLEDYHKLQLTVTHIEYRNIAPLYVDEELAVCGKPKLGKGYTTWDVWIEGKDGRLAFWAAPPVTRTLTALTFLQSILVHGGLLSGYYVLFLRRLVFKTLPEIWRLFSPFIITGPGLSLIFDLYFMFTYGSRLETESPRFSAPGDFFTYVFFVASIIMLTAGCLLNNVIFTSALILAFVYTYSQDNRGKKASFFIVQIPVEFLPWAMLTLTLVVSGWPAALRDGMGIVAAHFYDFLTRIYPTFGGGKNYLVTPAFVRRFFAASKPRGEARAFGTAYRATDQTQGSSGSWTSSFQSPWSRRGPGRRLGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2J8</accession>
    <name>A0A8G1R2J8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS drug efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_449186</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516005.1">
        <property type="nucleotide sequence ID" value="XM_025660109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2J8"/>
    <dbReference type="GeneID" id="37163511"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000429">
        <property type="entry name" value="MFS drug efflux transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="56"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH58083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="559" mass="59223" checksum="CEFD81D2A636945B" modified="2022-01-19" version="1">MAVDATMNHPSLEKEEGQLSEKSAASNLDSEDQQMDAPKEDEAPPRDITGWKWAIVVAAIYSSQFLFALDNTIVANVQPTIVEDFNAVSKLSWISVAFLIGAASTNLVWGKIFAQFNAKWTYIICIAIFEIGSAVCGSAPTMNAFIVGRAICGFSGAGMYVGLMTMLAVTTSIQERPTYVGGAGFTWGVGTVLGPIIGGAFTDSSAGWRWSFYINLCIGAICAPVYLFMLPNKDPRPGVSLGARAREIDYLGGILTIGAFISGVMAISFGGATYPWNSAKIIGLFCCSGVLFILLGIQQGIPVLTTKERRLFPVEFLRSRTILILFAMTASGGTLIFLPVYMCPLFFQFTRGDSALESGVRLLPFIILMIVAVIGNGAILSTHGLYMPWFLAGGILCLIGSALMYTVGLTTSVAHIYGYTVLIGFGVGLFSQASFSIAQAVAEPHMASSAVGFITCAQISGCTIALAIANALFLNKSVEGIKAVLPNVSSSEVELAITGTGSQLFDGLSEETKNKVLEAIVRALNNSYILSMVAAALVVVLSVFMKREKLFIAGGAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R369</accession>
    <name>A0A8G1R369_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_458882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516660.1">
        <property type="nucleotide sequence ID" value="XM_025661613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R369"/>
    <dbReference type="GeneID" id="37165015"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="45"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="198" mass="22513" checksum="621176BF13543FCF" modified="2022-01-19" version="1">MPLSYNKLDPSAKQIRLLTIFPDENDENLVRASLHTASLNDACDFEALSYVWGDTSVTVDISVDDCIVGVTANLHAFLWGLRQPNSERMVWVDYVCINQNDISERNSQVVLMYQIYSTARSVVAWLGDLEPEALELIEWYHANQKGFYFESTGLDLFEAIVVLLVSAKALCAAQYWHRLWTFQEWHLSRNAVGTSSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3J4</accession>
    <name>A0A8G1R3J4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_419374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516530.1">
        <property type="nucleotide sequence ID" value="XM_025657857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3J4"/>
    <dbReference type="GeneID" id="37161259"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000721">
        <property type="term" value="F:(R,R)-butanediol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034079">
        <property type="term" value="P:butanediol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08233">
        <property type="entry name" value="butanediol_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF23">
        <property type="entry name" value="(R,R)-BUTANEDIOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="8"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="356" mass="37769" checksum="E6851D08D0C5CCDA" modified="2022-01-19" version="1">MRAVRYHGRGDIRVEEIQEPGSCGVGEVKIRPAFVGICGSDIHEYLHGPSTIPSTTHPITGEKIPVTLGHEFSGTVTEVGEEVTRLHVGDNVAIKPNLFDGGCAACLGGWVNCCDNLGFVGFSGSAGGLSDHVVVKENRAVKLPEGFELDLGALVEPLTVAWHAVNRSSIQNVHARTALVVGAGPIGLAVLLVLKARGVENIVVVEVASQRRELASSLGATRVLDPRAEDVVATVRAMTGNAGADIAFECSAVQAGLDTALKGIRARGTMTILSLWSDKPAIYAFDVVLGEKHVVGSVIYEDGEFEAVIDAMWSGKLNPRALITSKIRMEDIVEKGFKSLIHGRDNQIKILVDISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R466</accession>
    <name>A0A8G1R466_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Translocon protein Sec61beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_448410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516273.1">
        <property type="nucleotide sequence ID" value="XM_025659928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R466"/>
    <dbReference type="GeneID" id="37163330"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH58351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="127" mass="12741" checksum="8A5D0F535FB816E2" modified="2022-01-19" version="1">MASPRAASPMTSGAESGPDSKSAGAGTGASAVSSVNRPSSPTPPGGPRAALRRRAAADHKESLRNARPSSTRAAGAGGSSGTMLKLYTDESPGLRVDPVVVLVLSLGFIFSVVGLHVIAKITRKFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4A6</accession>
    <name>A0A8G1R4A6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_438598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515402.1">
        <property type="nucleotide sequence ID" value="XM_025658678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4A6"/>
    <dbReference type="GeneID" id="37162080"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="118" mass="13344" checksum="6CE8B77BC87CA29B" modified="2022-01-19" version="1">MAPAPSVERIRELFSPWETGDDLDFIDNCSCSGLQICSPGNHCDRTDFSGCGKDWVSISMASKDGPLLLNGKPYNQTYLWATKWDGEHIVEVEEYADFELLANAVRENLEERRARDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4G9</accession>
    <name>A0A8G1R4G9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein VTS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">RNA-binding protein vts1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_369933</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA-binding protein involved in post-transcriptional regulation through transcript degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516254.1">
        <property type="nucleotide sequence ID" value="XM_025655944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4G9"/>
    <dbReference type="GeneID" id="37159346"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09556">
        <property type="entry name" value="SAM_VTS1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000033">
        <property type="entry name" value="Protein vts1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037635">
        <property type="entry name" value="VTS1_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="540"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="253"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="513"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH58332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="609" mass="65337" checksum="3174837F061C3E49" modified="2022-01-19" version="1">MASHIIGNRNSTPEASKSSLRPPSSSRNLGSHQLRASADMSGFPSPLSSRSIRPSSEVYFNQQSQASNNAEDPLDRAAQQWLADIDQYETTLEEMAAATLDQDFKDELSAIEQWFRVLSEAERTAALYALLQQTTQVQIRFFIQVLQQMAKSHPMSGLLSPANFGEKDAMSNRLNDAMSKLNVDSSRSSLGRPPPSPGAKRNSGLDSSTINAMFPDAAAAIAKKKAEFTQQTGNAPPSNRNSAVFDRTSFVAPTISAPDNSNDSLGQPPVSPWAQRGSEPQPPIARPKSSSGHQPMGQFSQTPSSLRSPLPTQTATIPAPEIDAPLLSPYNVGNASWASMTNTPMTATFGQQSQQPQQNSQADMVANATAMKLAALSTVNNRIALDDARKYRRARSNDGQGKNSANAGHGMSHGGLASPGLPGHNHLVAGQLLNTQQLAALQAQQQAAMAGRRSRPTSPGIAMQGAGGLGPMGFTSPQNNGFLAAYDPNNPLMGNGLGALGIGQFGLGGPEGYLSDHSEVARGRSPRGRRGSSKPPEDPTDPNLLKDIPSWLRSLRLHKYTENLKDLKWTELVELNDKALEDRGVNALGARNKMLKVSHRRFPRWLGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4Y6</accession>
    <name>A0A8G1R4Y6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_269285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517280.1">
        <property type="nucleotide sequence ID" value="XM_025655075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4Y6"/>
    <dbReference type="GeneID" id="37158477"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="257" mass="28186" checksum="9B662F88715EB75D" modified="2022-01-19" version="1">MDDTKVNIKRENFKDSLSKALNNRAASTKFPFAMTPSTSSAAPSVVWSASSSTPQKKRPILSPTFATRDAKRTITTTSTTTKPTIPAHLVADLKVLVEQLESATTPATTAAEADSTIYTEDNLREWGPFEQKSDGWGGTRENLPWVDTALNIIKQGEKVYEKNLKAFQDIADKLLTLGEQVQDIRAEMDAVCAKLHCFHEACLDLQIEVGNISSQEVCDITRLSLEALLEAHAGDVEGCATVKKALGKKDDEWNDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R532</accession>
    <name>A0A8G1R532_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vacuolar H+/Ca2+ exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_371289</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515822.1">
        <property type="nucleotide sequence ID" value="XM_025655993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R532"/>
    <dbReference type="GeneID" id="37159395"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000026">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000027">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF14">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="196"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH57900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="885" mass="97828" checksum="1986BFC3A94F2CC4" modified="2022-01-19" version="1">MVPSANLLGFAGGELAKKLPKVFGVLLETFLSSVVEIVLFMVLIHKDKGGNLIPVIQAAILGSILANLLLCLGLCFFFGGIGREDQSFHEAVSEVGSGLLLVAGFGLLIPSAFYATLKSNASHTHVQISTQTLNQSTLIISRATAVILLVAFIMYLFYNLHSHHSIFDEVLEFDEHLDEDREQEMKRAKLTLIECFVAIAISLACVCMSAVFLVEEIEDIVNERGVSDNFMGLILVPLVEKAAEHLTAIDEAWDNQINFALFHCLGPSIQTALLNAPLAVIVGWGIDKDMGLNFEIFMIVLVVLSILVVGNFLRDGKSNYLEGGLCVLVYVIIAVTTWYYPQIVAEGESEANHSMDPSSTIISALKDRELSINRDQIKSALVERIEGTELAKWLTEHLSTDTLLSQEELILYFQSRFTTDLSQSLIALVTIRYSKLEESGALQSLLTNPNLKATRPLVDDDLRRAIETLNASTAAIQRQTKTLASQYESLNGSITSDDELGLRQNRDNARLRQKHTDLAHALESELRGVSEQASADAKRILSSLTARFKEDDRLIANLERLASGIETSQQDENSAKIALERCTALAQCLADEIRCRLDRLYLESIQAGPTIARTEPAPAENEPLAALEEELESLYPEIEILAEMSTRQQFAEPIIGELSSHHEELQNASHETLDYVLDVVSEMTSSTNGLVKCLQDRESYCGTLEAIAAAHRSEIGDIFLGPPVNRRESLRRSSVQPVSGFTSAQKDNRLHESQSLAKVLRRVGLSLDSVLHADEASEYADNLKEKRYQLTESLNDHGIAADSPLMAELLPTDRAIQLLSTSLHADSEFETSLANMDHQRKLSNLEDDLKSVQKGLEGLDMSVVHRRDRGQEKFVEMWSSKAVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R553</accession>
    <name>A0A8G1R553_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_487151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516346.1">
        <property type="nucleotide sequence ID" value="XM_025663434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R553"/>
    <dbReference type="GeneID" id="37166836"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="308" mass="34481" checksum="EFB061563EC37C5B" modified="2022-01-19" version="1">MEVIINRLEASIKAAISRSVGEQKKNELDPELSKHFDLAKKESRQEQQGQGSSYSYKAVTSIKPEDVEKTFGISVDSTGGNWTLSAKDRVAIPQHLREALRDIDIVIEGAPLNEAHTRARIDAVLFSTLAAAKREERSNQNRMSSSSTQSVRSVHLQFEKDMKMEWTFPNKKRWLVTGRTDYSLWYGEPGQMEANLVVCEAKRKGVMGVDQTLVYMAMLHQARRAAGRHDTAIYGVATDSNIWEFIRLGNDSKYSVAHYRWDHGQGIQIISTLRRIIDHASGLTGGGAALGRKRTLSQASGIEFQSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5D1</accession>
    <name>A0A8G1R5D1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_393019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517414.1">
        <property type="nucleotide sequence ID" value="XM_025656865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5D1"/>
    <dbReference type="GeneID" id="37160267"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="561"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="683"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="726"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="796"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1143"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1239"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1264"/>
            <end position="1274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1274" mass="141885" checksum="69E84007E0C7E0BD" modified="2022-01-19" version="1">MSHPLGDDTASGPPPTPPFAPKGACPSSMFGGLEKSLSDVRLYISQHLGLIRASLHNGKPTALGGWRPVALRPPYLSWIAAIMFAMLITLEILRRYSDQYGGLYFFPDTDTVSDAQSFAYNYLPIIAALILVTLWTFIDYDVLRLEPYFQISRPEGAPASVLFINYNFGQSFLTPLTSAKRGHWVVLLVSLATLLIRVLLPALQSTLLELREITVVSNENIKTWPQLLDLHTQAVWIKAQKSNDTLALDSVLTARDNLHSSQSSSYAVAPVEISMEDRRESTVWTLNQTIYWSQMECRNIVAHDHLSVSINDTSSDPPILSWDVSGVQLQDIPGTNETCTLDFHYSNIFFPTTDYLQVRYWEPVWNNQSQPVYSRRKAFTTHGCDDPYDLYGVVLSVNATVAGANSISQLGSEFTSSAGIFGCKVEYRQAEAKVSMHANSSITNIYGYADTERELGTDQLNIDAFQDLLAQRAPYTGDMLFIELNETTGDTTVTELPVISQDLGDLEPLLVLDASTVMTTDEFESKVKRSVAETFVLTMSRLFNPDQNPTNVPAQRESTQVAIAVVSFASLFSEVILAIAICLTISLLYFYGTRPNILQSDPSSIGAMCSMLTDVFTPYNILANPQPEFHQFSTRQLRQVLRNCWLRWQQGPTGPRLEIITADGSPVTLSEQLRTRVDPMPHFLVIPIFIIEFLLLAAVIAVMGVTAATLAHDGSFQHLSQSSSSLLQAITSFLPSVVASSVAALCNSILRNISILEPWVHLQRGMVAAQTSLSMNYASQNPWSILRKAVRNRHTLLSLVSLACIANILLTVVAGGLFTQRLTESYLPSTSLYVNYSNSHFLRTDFAPDFTEFDLIQNSATSGVPLLPWMSANHSFAPIKNTDSDPDLMYGATTLGIGSDLDCKTLETSQNLREDGQDTFFVYRPSRDVSRQCRVNMTSLVRPSDAIALSIHFLSPVADTDTDLCQMSTVLVVGRWNYTSESPFTDDNTIALQCEPHVQLQNFSVTFDRRGQISDIDPIPGTETTSGTMYENATMALGQFNKVFAAIPQSFVGEEPGRNRSYVSSYDWAGFLVARLYRQHEKIVPLNALELMTQSQVVYQWVWSTYFTIWRNMYLVPLDEVVSAGNATEISNTWTMVPSVPSLAMALVIIALDTLVVLVVFGTRRGRFRGPRMPRSIGAIIPWVAHSRMLSDFRNTYSWTNEQRREHLTRLDKRYGFRMFLQADGRWRYAVDEEAVGLVDKPPDGGTDAAKGPEVIEMQPIGESRVEPGPDHHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5H2</accession>
    <name>A0A8G1R5H2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenases/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_369355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516948.1">
        <property type="nucleotide sequence ID" value="XM_025655915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5H2"/>
    <dbReference type="GeneID" id="37159317"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000173">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier protein] reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF127">
        <property type="entry name" value="3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH59026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="251" mass="26473" checksum="8D1356EE5F81502E" modified="2022-01-19" version="1">MSANDIRGRLALVTGASGGIGSACAHKLAENGAHLALTYSTNIAAIQSLHGDLQTRHPDLRISIHQVDLRSATDITSLFDQIIAQHDGHSPDILISNAGTGKRITNIWDIDISDFDDMITTNLRASFILVKGVVEHMKAQRWGRIVFMSSIAAYGGGINGCHYAASKGGLTGMMKNLATRLAEYNISVNDVAPAMIGDTGMIPNAAAVPEVVKGIPLGRLGTPEETANVVLMLVTTGYMTGQSLLLAGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5K3</accession>
    <name>A0A8G1R5K3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_449940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515127.1">
        <property type="nucleotide sequence ID" value="XM_025660270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5K3"/>
    <dbReference type="GeneID" id="37163672"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034703957" evidence="1">
        <location>
            <begin position="22"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="97" mass="10193" checksum="5EA366379B62AA05" modified="2022-01-19" version="1">MVKTALLPLALLAALAPFAAARNCKTGLNYCGWNLLNIGKYGAQVNGALDAAHQPTDDAHIRESLFHCNGGDNGDISFITYCGGGCKDGGKDRSDYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R666</accession>
    <name>A0A8G1R666_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_512522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516347.1">
        <property type="nucleotide sequence ID" value="XM_025664658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R666"/>
    <dbReference type="GeneID" id="37168060"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="244" mass="27625" checksum="CF14B744CF8A5240" modified="2022-01-19" version="1">MDMYDPKDVGVGNDITALAPYFRLGLDLTRAQDEEAEKPWLIDQNLTDVQIPKNLETLLEDFALGLGSGDCDTRLIRPRLSAILMVLLAKKIILPPVTDFETDTVEITMHFLLLYGCRPTLDTNVIVLRKQTIFPDEGWGVLAAMSAIHRQRKEAGDNGDIYGIHTDTYTWNFFHLNDSGKYSTKLDLSWYLDQKEVIGRVCHIIREAATLSREVGGRDPMLGVFEPETEGKSDDEKSDQWSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R690</accession>
    <name>A0A8G1R690_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_255022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517894.1">
        <property type="nucleotide sequence ID" value="XM_025654968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R690"/>
    <dbReference type="GeneID" id="37158370"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="157" mass="17426" checksum="A3B493A25F91C6EA" modified="2022-01-19" version="1">MMPSGSKVPDGQECDRGGEKAGQGFNFSTLSIRQPPPSMMEPIYSQTVRHTTLSTGRTEISLYQGPTGPERTDWPARDRLQSQTVRSPILSWLVASQHPYLPLIPPPPAAIIILSLPSVLFRVRRQRGRESSSSACLFIFPFQRSSSRNIPPFPIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6S3</accession>
    <name>A0A8G1R6S3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FYVE-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_447112</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518471.1">
        <property type="nucleotide sequence ID" value="XM_025659651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6S3"/>
    <dbReference type="GeneID" id="37163053"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15761">
        <property type="entry name" value="FYVE1_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="205"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="344"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="542"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH60549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="678" mass="75317" checksum="1E225CFBFBDEB1F6" modified="2022-01-19" version="1">MPRRTLGGGRVLGPANARSPSALFPSPQPNNPRHLTLSPSASSVSLNSQASTSQVSSEAQDLTSRISLENGSTSIPAAPAAAGAQLACPICSEEMVTLLQLNRHLDDVHQNLEDDRQDEVKDWFKTQMDKAKRFQPLAVLNQKLKGLDVFESNENIHPFAGPSRPSGPLPAHPPEPPRALDPDDVITRDHWQGRTLYDVCLEPSCGKRLNATNGCVNCRKCGKLFCEDHTMYQMKLSRSAQHEPVRGLWCRVCETCYKSREGYNDHNGLVRDRMSEFKAMRKQTVDKDLLEISRLEKRLTRLTQLLASLPAEQIQSSTNKLWSISWQGDQRKALEQTIVSWQDDSSVSRCPFCQQDFTSYTFRRHHCRTCGRVVCGDPATACSTEVPLSISPLAKTPAEKSPRTGVINVDIRLCKECRSTLFDRRDFEADIMRKPPAVRAYENLTQFERGIRILLPKFQKILGALQDPRRPPSSAQIAEASKVRKRLTDSFAQYDVAARRVRDMQTDSPTQQRLQKAIYQQASNFLHLHMLPLKSLPRVLKHASPNGGLSNSTSSPASPSPSNGSLGGPRRQGSALASIKYGNLAASGSNASLASDTSSAVSALEAEEKSLRERLIVLEEQKFFVSEMIADANRRRKFDEVSSLAMNIEDLTREIDRVNGMLDGLDFEGVYTGAHQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6S7</accession>
    <name>A0A8G1R6S7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_284003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515727.1">
        <property type="nucleotide sequence ID" value="XM_025655225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6S7"/>
    <dbReference type="GeneID" id="37158627"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000013">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="177"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="586"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH57805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="951" mass="107423" checksum="0E1132DAEF95E391" modified="2022-01-19" version="1">MDPEDSLADPFSSHGLWRVSKFTLQSLQPLEPLGWDEKLPDLSSAFLESPLNIFDKFGTEIPSLNPFGTELSDADQTLVLDTATSSENEVIATTDQQNVEEELEDIWALGSQDIKQERCDLLKSWEKYRERTYREPVSAYFSESGAKGFDAALARQAAKVGTQTQRFMVRRDVFFQALLKLGLGWSSMFFCYDEQNKRFERVHNNIRISGVTSVALNGITEELLECGTNMQKIRAFANKVPSRTKELSSRSAFASAAAVVVLTLEKRLVGQFASITSLLQIKALFCECGKVVSVLANVIEAVDIAMSEAQIISVVSERAAHFSQTFDHIEPLLREIVSRVAEPWLRQVETWVGLRPETAASVELASSGRSFVVAENQERTRKTTKMPRVDYKYLPDNMPSLIPNDLASLVFESGRSLRLLKTHHPQHPVANHEMYHSTSPTFECAGTWFDITRIEKKAAEYEARLRFEILKYNRGDMNQGSDRMFVTEASEPTGESGVLADTFELFDLDNMPNTTGLLPMDGSSRDKLGCLVDANVHCHAEQPAAHSSFGPEITSSYYLSLAPLLCSQALLIDFSCLHLLFKEHHLRTHLNLQWRFQLLGDGYFTSRLSDSLFDPDMESGERKTGVVRSDIHAGLRLGSRDTWPPASSELRLVLMGLLNECHDAEKLLDPSMNSSLWNEKELPGGLSFSIRDLTDEEVVKCKDPNAIEALDFLRLQYKPSPVLETILTPSSLDKYDRLFKHLLRLLRMDSVVRSLIRDSTARDSLSGDTRNVIQIFRVDAQHFVLALSDYCFHVGIGSTWRRFQETLSNIESCLDRHDIDGTIEAASSVPRLRDYHEDVLDQMLYALFLSKKHTEVAILLDEIFGTILTFAPLSQLDGINGVRHEAEPAVRRLYNLFRKQTSAFIGYLRSIEGIKSTSKSLERWDTTFTAKEEPATVFDHLLVRLDTKRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6T3</accession>
    <name>A0A8G1R6T3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_225057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518270.1">
        <property type="nucleotide sequence ID" value="XM_025654736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6T3"/>
    <dbReference type="GeneID" id="37158138"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="142" mass="15449" checksum="373C37DB9D1E0D22" modified="2022-01-19" version="1">MPLGLVFLGSRTILTSQPVIRTMQVERFAGGYPVLGPEYYKDEDIPNPGLPKAPHIGGRAPPLYLIFRSAGPGKDSLGRDRQKSNEVVGTSCNENGGKFPLNSPVLDEARKKYGENWVYVFAGRNPKGVSSRNGSPVQPVDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6W7</accession>
    <name>A0A8G1R6W7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ribonuclease T2-like</fullName>
            <ecNumber evidence="4">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO85DRAFT_446842</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="4"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518224.1">
        <property type="nucleotide sequence ID" value="XM_025659594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6W7"/>
    <dbReference type="GeneID" id="37162996"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.730.10:FF:000004">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057328">
        <property type="entry name" value="RNaseT2L_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25488">
        <property type="entry name" value="RNaseT2L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="RNase T2-like C-terminal" evidence="19">
        <location>
            <begin position="312"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="266"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF25488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RAH60302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="431" mass="47422" checksum="27F6A4BDD899DACA" modified="2022-01-19" version="1">MLDTGSTSAVGSTAISMRDRLLQSVPGPQQVLKAITGTLGVSSLSVSDYSSSEATFRQCPSSEVSCKAQYHGQDTCCFNYPGGQMLQTQFWDADPAIGPADSWTIHGLWPDHCNGGFDQYCDSGRRYSNISLILVDSGRGDLLDYMSDFWKDFRGDDANLWEHEWNKHGTCVSTLETHCYTDYYPQQEVVDYFDRTVEVFRTLPTYETLAKAGITPSYTQTYTRDEIVNALSKAHGAEVTVRCRHQAINEVWYYFNIAGPLQTGKFVPSDPDGQTSNCPRSGIHYIPKTPRNGHEPTKTSRGPAEPTAPSSPFSGKGNLMISTNGQKRGCIISHGAWFTSGTCATFTANKASDDTVTLKSSKGDCGFSHDVFTCGGFIRSPTQFTVEDGMLAYNDNTTFFADKAPKGPTKSKVFATQDDHPLELSITWREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R730</accession>
    <name>A0A8G1R730_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_511306</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516827.1">
        <property type="nucleotide sequence ID" value="XM_025664584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R730"/>
    <dbReference type="GeneID" id="37167986"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="5">
        <location>
            <begin position="66"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="6">
        <location>
            <begin position="252"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH58905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="363" mass="41059" checksum="C8690F95A8B54DED" modified="2022-01-19" version="1" fragment="single">IYEVMADDNLPAVDFIDRRGLILDSERKSVTNIHPKGFFIRHPPAPHELNEDLTPESKLFQTIHMGAAVVDTGRWKLIVDGLVERPFSINLDQLRKMPSETVTSFHECYGSPINPPTKNVWRIGNVKWTGVPLHYLLSIARPDLERGLFVWSDGLDSGEFAGVSAERYQKDLPIKKALSCEVLVAYEMNGQPLTKERGGPVRLVVPGWFGTNSTKWLCRLSVQATRSKGPFTTVFYNELDPTDSEGVRKRPVWKVEPNAMIVRPRPDDVIVGLGYVEGWGRAWGADEIVRVGVSLDGDSWDEAIVSPRKQFEWQIFSFRVEVHRNGRHHIQARATDKSGARQPLTGRRNHVPTVQIWVQSNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7P1</accession>
    <name>A0A8G1R7P1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mago nashi protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_446200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518966.1">
        <property type="nucleotide sequence ID" value="XM_025659454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7P1"/>
    <dbReference type="GeneID" id="37162856"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH61044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="154" mass="17891" checksum="1DA67132B71E7A08" modified="2022-01-19" version="1">MSTQNEPFYLRYYSGHSGRFGHEFLEFDFRTLGDGRSAAVRYANNSNYRNDSLIRKEMCVSASMIQEVKRIIKESEIMKEDDSKWPQKNKDGRQELEIRLGNEHISFETAKIGSLVDVTESADPEGLRVFYYLVQDLKALIFSLISLHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7V2</accession>
    <name>A0A8G1R7V2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_484878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519056.1">
        <property type="nucleotide sequence ID" value="XM_025663271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7V2"/>
    <dbReference type="GeneID" id="37166673"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH61134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="171" mass="19908" checksum="96D4AC65859F9C3A" modified="2022-01-19" version="1">MDDSTKQLRERNLRQIRVVLSQLPPDVGSDTIRILGDTPNSILDPEDFLGSIRPFVTETEESLRGFDSGNETRFVAAKICRGKHSYFILDLNHSNYNYETAHECKTLIPIYVLRLSKRQPTIFRKRELDESIAKILRNMHNLHGQAPLPLFDNHYDPYLQYPNPRSPHYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8E9</accession>
    <name>A0A8G1R8E9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Toxin biosynthesis protein Tri7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_475477</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519311.1">
        <property type="nucleotide sequence ID" value="XM_025662729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8E9"/>
    <dbReference type="GeneID" id="37166131"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF27">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="8">
        <location>
            <begin position="230"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH61389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="419" mass="46659" checksum="C5EC18AF9FC4D731" modified="2022-01-19" version="1">MAISPDLLCTIVTILQSLITVTLIARTPRNSFLRWICLPSITYMAYIEGVLIRMTDHHTYAKVTLSGMPFTVLIQHINLLLVARVDLTGQPGTIARKLASASALLQSTRGIGTPWQVKNIPSHPLVLRAKPPSRGYFIIRQLAIAIWEVLALVLVLSSLATHDVQDYDGSYIYGSGREFEMASSSMKQLLGRVTVAFLFGFPGSMLFLDSMYRVASIISVATGMTTIASWPPEFGSLADTYTVRGFWGKFWHQNLRWSYTGVSTAITCRILGLPKPSLIERYLNLTLVFILSGLMHVFTNVISGIEGGNTGAMLFFVAQAGAIMFEDAVQHYWAILSRGEQRTAGKTLIWQRCVGFMWVFCWLGATFPWWWYPIIRMLVAYDWIRVLDVVQGLGLTKSNLSVAVTVGAIILRMVFGAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R901</accession>
    <name>A0A8G1R901_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <shortName evidence="5">AS</shortName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aryl-sulfate sulphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_115336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aryl sulfate + H2O = a phenol + sulfate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140317"/>
            <dbReference type="EC" id="3.1.6.1"/>
        </reaction>
    </comment>
    <comment type="PTM">
        <text evidence="6">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519656.1">
        <property type="nucleotide sequence ID" value="XM_025653864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R901"/>
    <dbReference type="GeneID" id="37157266"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018958">
        <property type="term" value="P:phenol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000051">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012083">
        <property type="entry name" value="Arylsulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000972">
        <property type="entry name" value="Arylsulf_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034756328" description="Arylsulfatase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="6">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000972-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH61734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="581" mass="64992" checksum="123976110B720479" modified="2022-01-19" version="1">MMFLPALLALFVGCDALAVQQQVLLDDEPSVSARKPNFLFILTDDQDLRMNSPAYMPYTQARIKDKGTEFLNHFVTTALCCPSRVSLWTGRQAHNTNVTDVNPPYGGYPKFVAQGFNENFLPVWLQSAGYNTFYTGKLFNSHSVATYNAPFVNGFNGSDFLLDPHTYSYWNATYQRNHEPPRSYEGQYTTDVMREKASGLLADALDSDAPFFLTVAPIAPHTNIDVEGLGGSGGPKMTEPLPAPRHAHLFADAKVPRTPNFNPDKDSGAGWIQTMELQNQTVIDYEDHLYRQRLRALQAVDEMVDSLITQLEESGQIDNTYIIYSADNGYHIGHHRLPPGKTTGYEEDIRVPFYIRGPGIPEGKSVDRVTTHIDIAPTLFELAGVPLREDFDGTPMPVSTSKKTESILHEHVTVEFWGHAVLEGEYGSIGPGGSSMMGNNTYKSARILSEEYNLYYSVWCDGDHELYDLSTDPYQMNNIYAQQDSINLLNRPLSSVIDRIDALLLVLKSCKGNTCIQPWRVLHPDGSVESLKDALQVKYDSFYTNQPKVSYSVCEPGYIIAAEGPQVGLQYREGLSWEAWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R922</accession>
    <name>A0A8G1R922_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate dehydrogenase complex component Pdx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_447294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518639.1">
        <property type="nucleotide sequence ID" value="XM_025659691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R922"/>
    <dbReference type="GeneID" id="37163093"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="2">
        <location>
            <begin position="42"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="289" mass="31057" checksum="BA231FEF8D7E2600" modified="2022-01-19" version="1">MASTFSVCRLPAALARRQSRVLSTSKRLNSTSAPQFQNPAYPLYPSVTQLLHEKGIPESEVSKIPASGPKGRLLKGDVLAYLGAIPASYPSEQAARIDKLAHLDLSNIKIAAPVKPAEPAPAVEEKPVARPPPTTSVAVSISLAAVLSVQKKIQESLGTTVPLSTFLARATDLANDDLPRSSLEKPSADELFDELLGAQPIKFSRGEYIPELNAEEARPVQKKQKVEDDLIDFLAGKVSKKAVATAKSVVEPAANVFSLTVPVEEEKRAKVFLDRVKTLLTVEPGRLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA04</accession>
    <name>A0A8G1RA04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 14">DNA mismatch repair protein MSH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">MutS protein homolog 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_389834</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520275.1">
        <property type="nucleotide sequence ID" value="XM_025656751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA04"/>
    <dbReference type="GeneID" id="37160153"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000008">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000006">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000004">
        <property type="entry name" value="DNA mismatch repair protein Msh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001909">
        <property type="entry name" value="DNA mismatch repair protein msh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF122">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="17">
        <location>
            <begin position="965"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH62353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1118" mass="123083" checksum="7CA2B911D483C03C" modified="2022-01-19" version="1">MPLPSSQTSSSPGVKRKQSTLASFFTKKPQTAQPAPVNVVEEKNPATTPEEADNKERAPKKDTALTDDEEDDIVVPAPKRARTNGLHLSSKEEVPNSTSTTERPPALTSSQRTEIFKFSSSPAVNTGAEGPQAAGELEARQRQKEREALHQKFVRKLGGADCLIGIGRNAISEATPEEGAEAEDEEEAAPPPPAKGKAAAKKGGSKLTPMEKQVIEIKRKHMDTVLVVEVGYKFRFFGEDARVAAKELSIVCIPGKLRFDEHPSEAHLDRFASASIPVHRLHVHVKRLVAAGHKVGVVRQIETAALKAAGDNRNAPFVRKLTNLYTKGTYIDDAEGLEGPMPAASGGASPATGYLLCITETNAKGWGNDEKVQVGIVAVQPATGDIVYDDFEDGFMRSEIETRLLHIAPCELLIVGELSKATEKLVQHLSGSKLNVFGDKTRVERVPRSKTAAAESHSHVSSFYAGKMKTASAADDAQASSLLQKVLNLPEQVTICLSSMIEHMKEYGLEYVFELTKYFQHFSSRSHMLLNGNTLMSLEIYQNQTDHTTKGSLFWTLDRTQTRFGQRMLRKWVGRPLLDKSRLEERVNAVEELKNPEKMVMVERLKGLLGKVKSDLEKSLIRIYYGKCTRPELLTVLQTMQMIAQEFSDMKSPADTGFASAAINEAITCLPTILEDVIAFLDKINMHAAKSDDKYAFFRETEETEDISDQKLGIASVEHELEEHRSVAGQKLGKKTVEYKSVAGIDYLIEVENSSASIKRVPASWVKVSGTKKVSRFHTPEVIQLMRQRDQHKEALAAACDKAFISLLADIATKYQPFRDSVQALATLDCLIALATIASQPGYVKPEYTDHTCIQVDQGRHPMVEQLLLDSYVPNDIDLDSDKTRALLVTGPNMGGKSSYVRQVALIAIMGQIGSYVPAQSAKLGMLDAVFTRMGAFDNMLAGESTFMVELSETADILKQATPRSLVILDELGRGTSTHDGVAIAQAVLDYMVRSIRSLTLFITHYQHLSSMVHTFADHELRNVHMRFTESGTGTDEEITFLYEVGEGVAHRSYGLNVARLANLPGPLLDQARQKSKELEEKIRRRKLAGLVTAVGEVMEGTKDGNMIERLISSAEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAL0</accession>
    <name>A0A8G1RAL0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GABA permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_500903</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519528.1">
        <property type="nucleotide sequence ID" value="XM_025664141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAL0"/>
    <dbReference type="GeneID" id="37167543"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF8">
        <property type="entry name" value="PERMEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="532" mass="57308" checksum="3C2348CE152D4ED0" modified="2022-01-19" version="1">MAISEDEIQPVGPSTTGEDVRLEHLGYEQELKRSFGLLGMIGFSFSVVTSWTALSGVFIVGVTSGGPPVMVFSFIGVSLLTLAVAIPMAEMCSMYPVAGGQYSWVAALAPPKISRQLSYITGWFMLIGLLAMGATNNSIAAQFVLGMANLVFPSYEIQRWQTVLVAYLVAILAAAINIWGPHLLNRIARFILIWNITAFFITVIVLLATNDHKQSASFVFVEFQNFTGWDRAMAAIVGILQACFGMCCYDAPSHMTEEMKSASKQAPQAIIMSVVLGAITGFAFLLVLCFCIGDITTTQNSPTGVPVIQIFYDSTGSKVAACFLASMIAVIVIVAGNNILAEGSRCVYAFARDNGLPFSRFLAKVDKKRQVPINAVLLTLVVQLALDAIDFGTSTGFETVIAISTEGFYLSYAMALGSRLLGYVTNHRRTLTGPFALPTSMSISLNVLGLLFLLFASITFNFPESYPVTKDSMNYTSAAIGVIGVISVATWVVTGRKHFTGPGAWDGSGSRVTEGKVVELNEETEVEMEKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAW5</accession>
    <name>A0A8G1RAW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 15">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_413809</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S26B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 15"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520430.1">
        <property type="nucleotide sequence ID" value="XM_025657622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAW5"/>
    <dbReference type="GeneID" id="37161024"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06462">
        <property type="entry name" value="Peptidase_S24_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S24/S26A/S26B/S26C" evidence="16">
        <location>
            <begin position="35"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH62508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="170" mass="18882" checksum="7E6DF6FB2D8F44BD" modified="2022-01-19" version="1">MLSGIQNVRQTAIQLLNFGLVLSTAFMMWKGLSVLTNSPSPIVVVLSGSMEPAFQRGDLLFLRNTQPTLNVGEIVVYQVKDKDIPIVHRVVRQFGEGSEAKLLTKGDNNIADDTELYARGQDYLDRDDVVGSVFGYIPFVGYVTILLSEHPWLKTVMLGVMGLLVLLQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBI8</accession>
    <name>A0A8G1RBI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_359917</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521563.1">
        <property type="nucleotide sequence ID" value="XM_025655529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBI8"/>
    <dbReference type="GeneID" id="37158931"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="61"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH63641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="421" mass="48777" checksum="022A1A5403E5B0A4" modified="2022-01-19" version="1">MLSSLLRSLPQLGRRWKPLDFNNPNSTRIPNWHKIEEETLPEYTASQYYPTRIGEVIKEQYQVIGKLGYESTSTAWLARDMENRRYVMLKICIEASSMGQHVDNELNMYKFMEQSPTTHPGREVIRTLLDTFYIDGPQDKHHCLVHPPLWESVLAFLHCNPVERLPSAVIAVVLHRLFLALDFLHTECKIAHTDIKADNIMFGIKDDSVFTDIEENESRRPVPRKEGDERTIYMSRELKVPREVGAPVLCDFGSAMIVNDEYQRVFIQPQIYRAPEVILGVPWTYSADIWNVGCMIGQKRYKSIWDLYEGGSLLTGQDPVDERYRSRAHLAEMINLLGSPPESLLAQGELRDKFFSSEGGAFLHPELLTDQVPLDERETTLEGRAEREAFLHFMRKMLQWEPSKRSSARELAEDEWLQSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBM2</accession>
    <name>A0A8G1RBM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vitamin H transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_129070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520143.1">
        <property type="nucleotide sequence ID" value="XM_025653976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBM2"/>
    <dbReference type="GeneID" id="37157378"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000394">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH62221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="468" mass="51160" checksum="035148FDFA0E586C" modified="2022-01-19" version="1">MAEDSDYKLKCDASLSEEIENVITSPFSAEEEKALVRKVDLTLLPTIWIMYLLSYMDRTNIGNAKISGMQEDLDLTSDQYSIALVVFFIGYVVFEVPSNLVLSHTRPSLFLTGIMVIWGALTCVMGVIKDYKHLVVLRALIGCVEAGFAPGVLLVLSSWYKRTEQSKRFGVYISAAILSGAFGSLLAAGIIQGLEGVQGIRGWRWLFIVEGSATVGVAIICAFILPDFPATSRRLSERERHVAIARLATDNVTSLTEDSPELSHWNAVVESAKDWRTWGFVVGYMVIVGSSTLSYFYPTLVKGLFGDSSTERVNFLTVPIYAVAFVCTAITAYFSDKIPQWRGLVIAGWLSASLACSIAVCVVYNYTARYVLLVLMAAGLWATNGGTLAYASSAFANMHPQVRGVSLALVNALGNLAQIYGSYLFPSSDGPKYIMGFSVISAMLALGVVVFLVIHVWFRRRATAISHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBN4</accession>
    <name>A0A8G1RBN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_224918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518262.1">
        <property type="nucleotide sequence ID" value="XM_025654735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBN4"/>
    <dbReference type="GeneID" id="37158137"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057082">
        <property type="entry name" value="PH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057081">
        <property type="entry name" value="PH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23076">
        <property type="entry name" value="PH_FT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23074">
        <property type="entry name" value="PH_FT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="292"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="419"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH60340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="535" mass="60531" checksum="3B565371E8E98CDC" modified="2022-01-19" version="1">MSLHDSYKTAEAVAEGFRSFSNLLPEHDTEITSLVVDLFSISLFLKGLEGMARNRAYRYRLSAIHPDLELVRASLNYTLEDVLDFFDDLESRRGDPSEAYKQLWLEISAHFLEESQESLSTRLAKYKSFLRDLSEIMKGEVTDTRLMASLRSNLKGLLVHQDSRLAPRLGSMSLSSPSSSSSSSSNGSNADPGSPVNGRRPRGRRSYERARPSHSSPQSPISTSSATFSDIPPSVPSAPDSPTTSTTATSQSIDSTPVSDHWARRVFLDEHPMTPIPYVGESSKCLGEVKGNVKGWLHEEGFEELFQLAFSGDSDLRVCFYLREDDHRVRIVCKSRRTSRTSDYSCLPLNLLEIVRIGSCLQICRRRRGGSELVLWANLKFSTIEQMVIFFCTFLALRSQDSGRPVERIRDYELDDEEEHFGGQIVDDDFLHALRVYRDNVSGAVRLQASVHKGEMKRLHRMPVWTAFITEHIGSRGWIRRVDTKTILLRDLRRVIFTFPSYNPPRTPKGEHILKFTNKSDAQGFMDTIAELAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBT2</accession>
    <name>A0A8G1RBT2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_445724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520233.1">
        <property type="nucleotide sequence ID" value="XM_025659339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBT2"/>
    <dbReference type="GeneID" id="37162741"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034425520" evidence="1">
        <location>
            <begin position="20"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="216" mass="23425" checksum="05808BEB06AD8A58" modified="2022-01-19" version="1">MLIFPTIATLVALAASSTAILHPRSITPPEGCPIPTWEVTTFHWYNGSKSLDCVHNEADINFKDCLCGNGWCAPDPATCNGSMVNVCWTGMPNYQPWGYGPPETLDIDFADGLTCHDEYIGYRVHDIGNGASNCGYADRGEGRIVSFYGSSNYATSTGHMDYVLGDGHALECANGSLITYSGSTNFTLTCTHDQYFNATCTAPDFVIPVLSYEWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCG7</accession>
    <name>A0A8G1RCG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell cycle control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_445595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520096.1">
        <property type="nucleotide sequence ID" value="XM_025659300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCG7"/>
    <dbReference type="GeneID" id="37162702"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="460"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="594"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH62174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="705" mass="82790" checksum="FBA412917E0C202E" modified="2022-01-19" version="1">MTLEDFEKSLAEEQEHRREKSDRSRHRHHRDRDRDRDRDRSRERRHHHRRHRSSRSRERDHERRRDSRRSEDDGHRHKRSRHSTDHGDDRDHAHKRRHRDSRDETDAPAPVEEVVQEEPTRMKRDAWMQPDGLDVDYVQRRNTTRLEEEPKPKMLQADFELKIHGKELNTHLHDLKEGKVLEEIEEQPAQHEVDYTFGDEGAQWRMTRLKAVYREAEETGKSVEEVAMNRFGDLRSFDDAREEEAELDRRERYGEGYVGKEKPTGELFQERKLEEDVHRDPHENLRSPGKELDAQGQGKTMETVPPPNTTQHLDLTALNRLKAQMMKAKLKRAPDAAELEERYNAAAAAMSNRKESDVVVLGVMENRMLAGTRNEVKAVENRRGRERGKVEENDEMTIEDMVQEERRTRGQFGGDGRRMAERIAKDSKFENDLEYMDDNASKLAKRVHRSEIDIKNITINELQKMNRILDNCPLCHHEDTNTPPVAPVVALATRVFLTLPTEPELNEGCATIVPIQHRTNLLECDDDEWEEIRNFMKSLTRMYHDQGRDVIFYENAAQPHRMRHAAMEVVPLPYSLGETSPAFFKEAILSSDAEWSQHRKLIDTLAKSKQGMGRSAFRRSIAREMPYFHVWFELDGGLGHVVEDENRWPRGDLFAREVIGGMLDLAPDVIKRQGRWHRGGDRRVAGFQKRWRKFDWTRVLVEGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDI2</accession>
    <name>A0A8G1RDI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phospholipase D</fullName>
            <ecNumber evidence="1">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_444412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.4" evidence="1"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520994.1">
        <property type="nucleotide sequence ID" value="XM_025659012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDI2"/>
    <dbReference type="GeneID" id="37162414"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000032">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF128">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="6">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="6">
        <location>
            <begin position="620"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH63072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="832" mass="95596" checksum="6907CA088AC6164C" modified="2022-01-19" version="1">MDKFKHKLENLEEQFKETHIEEKAFHLKHKVGKFFNIVNPNHRHDEAHEKATDAKRTAISESHRFKSFAPIREGNKVKWYVDALDYLWAVSMALEEAKETIYIADWWLSPELFLRRPPFMAQEWRLDQILKRRAEAGVKIYVIVYKEVNQALTCNSAHTKHALRNLCPEGSPGHGNIKVLRHPDHNIFENAADMTLYWAHHEKFIVIDYALAFIGGIDLCFGRWDAHQHPLADVHPSNLRNEVFPGQEFNNNRIMDFQSVGDWQANELSKAEYGRMPWHDVAMGVMGDCVYDIAEHFVLRWNFIKRDKYKRDDSVDWLMLEGRTGDDEDLVAVQRPKFPCGEYLQHPLTPLDTKPLGQQGFARAQIVRSSADWSSGILTEHSIQNAYKEIISQAQHYVYIENQFFITATGDKQAPILNTIGQSIVEAVVRAAKEGRKFRVIIVIPAIPGFAGDLRQNEATGTRAIMDYQYKSILRGEHSIFGRISAQGVNPREHVFLFNLRAYDRINKTPALVKLESEAGVTYNDVQRGIAESIMSDSVHPAIGKEGDKHEVGYDNAQQEKEVRLARLRKYEEQHERHKELEGLKGSDSVAHTTMLNGGKMSDEPWEGDPEDEKENFIQEELYVHGKVCIVDDRVVICGSANINDRSQLGYHDSELAIVVEDQDFIGSTMDGKPYKAARVAATLRRQLWREHLGLLPAQNYDASEDPNAKPPYMCMNHILEGPEDDFVTDPMSDELWEMWTGRATVNTDMYRMLFRADPDDNVRTFDDYDRICPRGIKQGHLFDPFQPVNEIREKLDKIKGHLVWMPLEFLKDANMAEPGLAVNQITESIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RES2</accession>
    <name>A0A8G1RES2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_122360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519897.1">
        <property type="nucleotide sequence ID" value="XM_025653923.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37157325"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF1">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="728"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="984"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1343"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1407"/>
            <end position="1417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1417" mass="157647" checksum="D6F22688065D9674" modified="2022-01-19" version="1">MATDRFPAPPTEAPTYLQQAPTNGIYTAPSHKRQPSHVVKSAAPDYYEDNDFYANPNNSRPPPPYPANSSRIQSHHRSRSYSTRSKSYRRDVYPEDNMEEGENLPTPDRPVWSEKRSKSSATRADKHGAEAHKASLSSNSQPSPVSRSSTVRSATEQRRDWASDRSPLQKLETTYTGASKEEKRARALEAEMKLRERMKRQTESRATAMAQPSESLESVDKRAVPGRMAEPRPAQGAKRSHHRHAASEGHTGYSPEGPESSERARPPRSRMPPSQDAAERAFDEIQDFNGGRPDGPMARTGTAPRRTVSVSHPPQGPPMGPRAMNQGKQRDAQPYPPSSSAPDSAFPDQSRMTVPARKAVPIQPSTRAPPVANPAAYQTKSSPQLIPERGPSMQGPTTQQGVLKNPTGTAPAKPSVDSGLDVNNPIMPSAPAETNVPSKPKVSFNVPPPTPPPLSEWRTAAIARLGASDFDFQRFDADRSKAWWETGESSNRRLSRALPNSFAQKPSAQKPTSNKRFQPSIFLQSGPLLRYAGLKRVRIDGPNGPFNKETWRGSVLIVTQDSLSSYEPRPTLRVFAQPMDLLAPPPVQVGGEDSQLAPEYVDPTAGLMKLGRDGRPLYVKPVEHTAEGEDLSFVENDDGIFELSPSIMDYSSEGVKQPVPANRIHSMDGETAGSYKEITGARLYADPGRDVTFWKFNIEIELGPTQQRVAYRLNHGPALGFWVPARGQSMNIMFHTGNGFSPAVDSNKLSGPDPLWRDVLNEHQTRPFHVMIGGGDQIFNDKVIAETAHFQEWVKIKNLGEKYEAPFTAEFKAELEDFYLENYASWFSQGLFSLANSQIPMVNMWNDHEIIEGFGSYPEEFMNSPVISGLGNIAFKYYLLFQHHSVPEETETEEPSWLLGAKPGPYINQRSRHLFMSLGDGVAFLGLDCRTERMTDEIISEETGELIWDRCHQEIVRNETRHLIVSLGIPLAYPRAMVKNILNSRKSLGKAGLFGGFVNKNGAKVEIFDDHWTSKRHKAERTYLIEDLQDLAAEKSVRVTILSGDVHLAAIGQFYSNPKLDVPKDRDYRYMPNVISSAIADMPETEMISDMLNKRNRVHHMDTNTDEDMVPIFTHDVNNKPRNNKRLLPRRNWCSIREYKPGKLPHIYYGVLRRDLHDASVSDRLIGTTPPGTPPDAPAEEEPRPAKLKRTLSLTRGEKPPRTGLLRRLSLRGPPPTKDFNLGEAPPARRMSMDGAFPTADTDDAGEPKPGPFLRRPTNLSQKSKRGDDGLGALINLEGGLAITLNLELNPKDPAGITTPYKLLVPILRYEDMEYDPPAASVPKGWKKWLGVRRKKADKAPVEDTDVEQGMTDEEDEDDGFDDEDDVRARFEIAQGGVLPPETLVPVSPDAGEMGMGGGEEENKEVPKRKKWFGRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RF04</accession>
    <name>A0A8G1RF04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-directed RNA polymerase I and III 14 kDa polypeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_444763</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521401.1">
        <property type="nucleotide sequence ID" value="XM_025659102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RF04"/>
    <dbReference type="GeneID" id="37162504"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000034">
        <property type="entry name" value="DNA-directed RNA polymerase I and III 14 kDa polypeptide (AFU_orthologue AFUA_6G04610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="7">
        <location>
            <begin position="46"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH63479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="137" mass="15177" checksum="D36FC92EFE013391" modified="2022-01-19" version="1">MPASVHSEEQDQSMLDASAPQEEQTDILELDEKRIVVLPGSSDTAASFQFEGEGHTLGNALRYAIMKNPEVEFCGYTIPHPSETKMNLRIQTYETTTAVEALEKGLDTLMDLCDVVTDKFTTARDDFNAAQADRMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RGU3</accession>
    <name>A0A8G1RGU3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_444399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520977.1">
        <property type="nucleotide sequence ID" value="XM_025659007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RGU3"/>
    <dbReference type="GeneID" id="37162409"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="78" mass="9650" checksum="0A3FA2DEE426AEC6" modified="2022-01-19" version="1">MMGEGSTEGKYMRVTRERRRGEGEEERVDDGGGEYRRVMRERRRDEGEEESVMKEMRRKKKWDEGTDEMEEKMRWWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RHG3</accession>
    <name>A0A8G1RHG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_455410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="RAH63400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521322.1">
        <property type="nucleotide sequence ID" value="XM_025661384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RHG3"/>
    <dbReference type="GeneID" id="37164786"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="434" mass="48194" checksum="A02B74638D6F7E9F" modified="2022-01-19" version="1">MAHPTMAMVTIDRPAAPAPDSSSPLKPAGQAKQPPSDPTATPDPNLVNPRLLVNGACIYERHLPGDAYITAHVQRLQHGFYASPAVSNQDHNHVDFLGITFVFHSPNTLSHRFKAATIRASVQSAREQSSSSNRTRHPRFLMHAPHLLYGAVSPETLQWNYSLSGSLGVSDLPLVASLSPSGGMNGRYKRYEMMRIQGSVRSLRSPRGRAFDVEGGEIVWTLEENNLQRSGLPREFTFAMLISKPRAESRVQFALDIDPVVQCWWSSYPGPLLALPRYKPVRRRPVDFRTEVGQRFEPLTADKGFNFAALESSFDDYVHMPGRKFSSGISPDGGIAQDDNEVRRDVTRDWTMIEPLRGVNKIPALLPGKSGLNPNQPIPAIPGFDPGSFTMRLLLDNAHGSSSRYAHVTSEVTNVRNGQRTERRMERRSKGNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8G1VH16_9EURO</name>
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        <submittedName>
            <fullName evidence="7">C4-dicarboxylate/malic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_463419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510818.1">
        <property type="nucleotide sequence ID" value="XM_025661927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VH16"/>
    <dbReference type="GeneID" id="37165329"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09317">
        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF3">
        <property type="entry name" value="TRANSPORTER_MALIC ACID TRANSPORT PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
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        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="483" mass="53504" checksum="62A76D1D8BC5149E" modified="2022-01-19" version="1">MTPDRLFPRHLRSPGDDGYRTPTIEDTQNDLAGNTGGDSYFHPRGSIISQAHTSALDAIHSSSYRKSEGDGDEGVDGMAYPQSEAETRPTGLGWKKRIRHITWAFFTLTMATGGIANVLYFGECVPCLRFRGLETIGIIFFLANLFLYILIWCLLITRFYLYPYTFKASFLHPTESLFVPASLVSFGTILINISQYGPNHTGPWLTYAVGILFWIDAALAVISSAAIYLILWSTQTFTIAQMTPIWIFPAYPMLIIGPHAGILSSKLEPARSLRIIIGGTTIQGVGFLVSLMVYSAFIYRLMSQKLPRENVRPGMFVSVGPSAFTVSGIVNMAAHAKRSFPEDFMGNGALAADIVKVVANFSCLWLWGLAIFFFFIASFAHWSAIGPGRMVFSMAWFSFVFPNTALITATFAIGKAFSCKAISIIGCAMVFPLILMYIFVCYMMVRAIVHHQILWPQKGEDKDEGGFEVNRIKPESPGENTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHZ9</accession>
    <name>A0A8G1VHZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_452776</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025660904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHZ9"/>
    <dbReference type="GeneID" id="37164306"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
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    </dbReference>
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        <property type="entry name" value="F1F0 ATP synthase subunit B, membrane domain"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="12"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH53929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="119" mass="13627" checksum="7DD74A589F959D7E" modified="2022-01-19" version="1">MSAQNSAGIQTLLDAEREAQKIVQQAREYRTKRIREAKSEAQKEIEEYRKQKEEEFKKFEAEHSSGYKKAEEDANKEAEVKLQEIKDAGNERGGKVIETLIHALVDVKPEPSEKIVIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VI00</accession>
    <name>A0A8G1VI00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_431167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510669.1">
        <property type="nucleotide sequence ID" value="XM_025658326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VI00"/>
    <dbReference type="GeneID" id="37161728"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034995332" description="Concanavalin A-like lectin/glucanase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26511" checksum="BF591CDD04FA2BF2" modified="2022-01-19" version="1">MRYSSVAIPLALAARAAAVESDVWAFGNGFYTGPPTNAHITRATWSLVPPDVPSNYTVNNTDDEVWVSLWIGLSSTAGDYDADLYQPLLNWSPDNESQGCPAPDDEWCVAASTYTPDGQNGQAYVTVPADTQVDFEVYVENDKVYQVVTMNGKTVSKESDALDNPLLYLYSGDECYTGSGDCGTLQSYSWNNLTIHLSAADENFGDTLSLYSGSSSNGLTTSDKGKTWHTDAIKISKDTFANVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIA0</accession>
    <name>A0A8G1VIA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_505117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510969.1">
        <property type="nucleotide sequence ID" value="XM_025664324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIA0"/>
    <dbReference type="GeneID" id="37167726"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="312" mass="33471" checksum="51D2CC7BE090046C" modified="2022-01-19" version="1">MSSSTEGGRLICPECRGFCDVSDTCPTCTAAESVILKAEISDSQDDTALKMAPSAEHSPQQANSEASSATAKAASAPPSPSAPQPPPAQPAPTTPPKKASKPTKKTKKMESSSDSNNSPKEKLTPACAPCKKAKRRCVHRSVIPDAEGQGASQPSKKRKQTAEPGANPKRAKKNDGDVSGNETGSEEGQRIKLKFKNHQAQFNTETGESTPKKRGRPSKTLPGNAEAGALPSIEEEDEEEEVPQKQAKDKNYGLPKDSLVAASRVTAFKHLDRQLQDKIADCEDKWKAAKDTVDEIRYILNKWIALWEQGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJL7</accession>
    <name>A0A8G1VJL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-dehydropantoate 2-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_471176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512334.1">
        <property type="nucleotide sequence ID" value="XM_025662454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJL7"/>
    <dbReference type="GeneID" id="37165856"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="253"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="439"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH54412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="577" mass="62555" checksum="554E429FD0B3DB9A" modified="2022-01-19" version="1">MTCEACRTIPPVISSGYTPKGTYTQIADLKTYITGPATATTGIIDIYDIFGLSNQTIQGADLLAARLNALVLVPDFFHGERADLAWFPPDTEEKKAALFGFIHTKAAVKDKVEVVRRVAEDARGRFGGVRSWGAVGLCWGGKVSGPNSPFVATGQVHPGFMDVEEAKKLTVPHIVLASKDEPVEAVKGYADVIAGNGIGGVVETYPTMWHGWMGARAQLETPEGLAEYRRGYNQLAGFFENNHHMIMTAPPSILVFGVGSVGAIYLHQLQRAGCTVTAVCRSNYDVVAHHGFTLRSPRFGTVTYRPDHTVRSVHDCPRDIQYDYVLVTTKAFPGRTPSLADQLRPVLENHPHTAIVLAQNGIDIEKDIADAFPYNPVISGVVYLPTVQTEAGVIDHAEPLDLLELGTYPARAPEEHTGAAKKFVDLMIKGGGDAVLFEDIQEARWAKLLLNAAWNPICALSLCTDGGFLLTSEPFARDLAWGIMMEIVALARAVGIAGVDEAAAKKRFALAERRAKEGTGREMSMLQDVKMGRPFEVEAIVGNAVRLGRKCGVSMPRLETVYALAKGRLDVLMGCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKD0</accession>
    <name>A0A8G1VKD0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_376335</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513487.1">
        <property type="nucleotide sequence ID" value="XM_025656221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKD0"/>
    <dbReference type="GeneID" id="37159623"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="669"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="335"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="401"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="465"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH55565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="741" mass="84669" checksum="00FC8EA6FD9802D7" modified="2022-01-19" version="1">MAGVNQASSSGVDLSSEVRRRTAPLTQEPSRAPDHDAYDAKKSKQEPSSFRSAVASWEPIFAPLFLTALAIFTRMYQIGRSDIVTWDEAHFGKFGSHYLKREFYFDVHPPLGKMLVGLSGFLAGYNGSFEFKSGEKYPEDVNYTFMRIFNAAFGAVCVPLAYYTARELGYRKATVWLISLMVLFENSYATISRFILLDSMLLCFTFTTTLCWAKFHRLQKASFSAEWFAWLFLTGVSIGCVCSVKWVGFFCTAIVGLYTVEDLWNKFGDLKMPEVVVAKHLVARIVGLIIVPCIVYILSFYVHFWVLENSGPGDAQMSSLFQANLKGTEVGKDSPLEIALGSRVTLKNMGYGGGLLHSHIQTYPEGSTQQQVTCYHHKDSNNDWFIYPNRYEPDYDPEDSLRFVGDGDIIRLIHGQTGRNLHSHAISAPVTKSQFEVSCYGNITIGDDKDHWAVEVVDDVASRDRSRIRTLTTAFRLRHPVLGCYLRAGNVNLPQWGFKQIETTCVKENKPSDVYTHWNVESHYNERLPPGDPGSYKSPFWKDFIHLNVAMMTSNNALVPDPDKQDDLASKFWQWPILNVGLRMCSWDDNTIKYYLLGNPFVYWGSTLSLGIFALLVLWYLVRWQRGYTELTQADIDHIHYSGLYPVIGWVLHYLPFAVMARVTYVHHYYPALYYAILTFGFCVDWFTQQMSNKLRWAIYTLLYCAIVGLFAYFRAIVFGIEGPSQQWSHLNWFSGWRIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL46</accession>
    <name>A0A8G1VL46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_450666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513939.1">
        <property type="nucleotide sequence ID" value="XM_025660429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL46"/>
    <dbReference type="GeneID" id="37163831"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH56017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="51" mass="5611" checksum="DEFA6A45A1419047" modified="2022-01-19" version="1">MAFLNDLTTDFDYTNIVAGCCTRHSFSAKYEAAKNEARTDGYLVDGNESPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL57</accession>
    <name>A0A8G1VL57_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-propionate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_57156</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513969.1">
        <property type="nucleotide sequence ID" value="XM_025665496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL57"/>
    <dbReference type="GeneID" id="37168898"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="14"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH56047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="596" mass="66300" checksum="FA81922514C1AC33" modified="2022-01-19" version="1">MSPIKEEVHCDDHVPILIVGAGPCGLLLAYLLAQLGVRSLLCERYPTRLQVPKAHALSPRTLELCRQYGLDVNEIRSIGTKRGEAFWVNFITSLSGRQVGRLPYERMDPAVLESTPTMIHNIPQPEFEELVAKRLSKNNLVEIRKNHSFVRLTDRGDYVLATIEDRATQQEYTVKCSHLVACDGAKSAVRRCLGIESEGEDSYETMMTIHINADLHPVVKERVGMLHWVMDPEVSGFIIGYDLGGNQVLICNFDAEKHPVNCRKVVDAAIGAKIPYDVLSYRPWILSRKVALAYRANRVLLAGDAAHSFPPTGGLGLNSGLGDVHNLAYKLAAVHHGWGGDKLLDSYEADRRPVACDNAEQSVKNGKQIFGLLKALGTTDPDVQVARQNLYRNIEDTQMMKEINKGIEGQREHFDNLGLHVGYVYGNHKRPDCASTYEPVCIPGARLPHAWIELLTPDQIRLPPIDCSYVSEFLPEELKLKQFSTLDLCAFDAFTLIVDIRSADHWGKILEEVKRQLPGKCRGLKLEMMTRGANFDFQAGGGEKWMALTRLAEGQAILVRPDQHVLARFEYPGESSGVLGELRAHLAWDEGIGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL94</accession>
    <name>A0A8G1VL94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH OST-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_500440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512395.1">
        <property type="nucleotide sequence ID" value="XM_025664121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL94"/>
    <dbReference type="GeneID" id="37167523"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10146">
        <property type="entry name" value="LabA_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11297">
        <property type="entry name" value="PIN_LabA-like_N_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35811:SF1">
        <property type="entry name" value="HTH OST-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35811">
        <property type="entry name" value="SLR1870 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH OST-type" evidence="2">
        <location>
            <begin position="172"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH54473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="255" mass="28579" checksum="53312632DAD79621" modified="2022-01-19" version="1">MVADAMPKFAVLIDADNARHSNIHRLLAEIAKYGTVHAKRAYGDWSSQYLIGWKDQLLHHAIQPIQQFAYTQGKNATDSAMIIDAMDLLYTSRYDGFCLVSSDSDFTKLASRIRESGLVVYGFGEQKTPKPFVAACNKFIYTENLVHVDELEPHATSIRAPEHRVAIEKVQTDEPLATQLRTSVEAASGDDGWASLSEVGAILTKRHPEFDSRSYGYHKLSDLIAASSLFETNFQSHPHNSSTRIYVRDTRRKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLH4</accession>
    <name>A0A8G1VLH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="9">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_452129</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>CDP-N,N-dimethylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33775"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:65117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33776"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="9"/>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512635.1">
        <property type="nucleotide sequence ID" value="XM_025660753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLH4"/>
    <dbReference type="GeneID" id="37164155"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000012">
        <property type="entry name" value="sn-1,2-diacylglycerol cholinephosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH54713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="408" mass="45713" checksum="304E37143AD0A33C" modified="2022-01-19" version="1">MVYIRQHQLPKLREYRYAGVDLSLVSRYVLKPFYNNFVIKFFPMSMAPNAITLTGFFFVVVNFITILWYNPTLDQDCPPWVYASCAIGLFLYQTFDGVDGIQARRTKQSGPLGELFDHSVDACNTALGVLIFAAAMNLGQSWATVLTLFGSTMTFYVQTWDEYYTQVLTLGIISGPVEGVLTLCVVFGFTAYMGGGSFWHRSMLETVGVPKLAFIPEHIYDMAFTQWYLVYGGVLLFFATASSIVHVMQVRRERGQDPIKPLYGLLPLVAVWTLVPAYLYLQPTILENYMVPFCLYVGMINAYAVGKMICAHLVKASFPYFNMLLIPLALAVLDSAGAVFGYWPSLLGDGVRQIAFVWVCLGLSIGVYGSFVHDIITTICDYIDIWCLTIKHPHVEVVNANGEAKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLI0</accession>
    <name>A0A8G1VLI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein sec72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_450135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514672.1">
        <property type="nucleotide sequence ID" value="XM_025660307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLI0"/>
    <dbReference type="GeneID" id="37163709"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF3">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH56750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23500" checksum="B49C737BABAFAFDE" modified="2022-01-19" version="1">MASVDLFTEYPLHLDPTSKSISLNTTNTTTLPTSPATITTELTHLNALHRSLISLDPPNIPPPPLPINPKRSAQITKLRDSANTAYRKSNHAEAVRLYTYAIDMALGRPGWEPVTLARDELAGLYANRAQAWMSQRAWPEGLVDARCSVESKPVANVKAWWRGGRCLVEMGRWEEAKGMVEKGLEIEGRVSEGGKELLGLLSEVEEGLKRSGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLI6</accession>
    <name>A0A8G1VLI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF803 domain membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_373944</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514687.1">
        <property type="nucleotide sequence ID" value="XM_025656107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLI6"/>
    <dbReference type="GeneID" id="37159509"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034002125" evidence="8">
        <location>
            <begin position="21"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="479"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="575"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="742"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="795"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="822"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH56765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="837" mass="90749" checksum="1318F0F9816697DD" modified="2022-01-19" version="1">MAYLQEVPLAAGLLTALASSAVPTPTPTPFHYFPSSSQPSPTFTSSPGSDNGDGGNGGGMHEWSSLIGIVTALAGNVLISLALNIQRYAHIRIDKEWEQDKLRHELDWKRANHGHGHSGAYGSVDDDDFDGDASRGRHRASRPGRYRDESPTSEPDHYEEPRGHSGRNRRYRDDETDSQDHMQDSMISDRTARSGSERLRRKSYLRSPYWWVGIVLMSLGEVGNFMAYGFAPASIVSPLGVVALISNCVIAPFMLKEKFRQRDLWGVLIAIAGAVVVVLSAKSSEEKIGPHDIWEMITRWEFELYLGVSAALIVGLMWASGKYGSRSILIDVGLVALFGGYTALSTKGVSSLLSFTLWHVITFPVTYLLVFVLVFSALMQIRYINRALQRFDSTQVIPTQFVLFTLSVIIGSAVLYRDFESYTAERACKFVGGCVLTFMGVYCITSGRVRADNESTFSIDDEEEAIGLLGADRYHDRVDLSPPAPQARAHKAGRKVRTPAEDHLQSPSGSLLSQGIEDVDDDQRTPRGVLSAAPSSPRGSLTAELLEEPSSEPSSPMHARSLLTNPWADSLESAIQTPNTEPPIHRPSTPPAQSELTAHDSPFLLRFPPAPGAEDESAGPTSGHGRTQSNVRKAIVPQTPPARHLRNSISKFSPGPLLPTISAGFSAVVAETLRRGEISPNKGRRLHHRMDRRKQLSTTVLEGFTRQRNGDARGGEYEVDGDVENTHSLGFPLSSSRLPGTGALATAPVSTGDLTPAVDSEEGPINQHEDNTTSLSRLRSLSDSWSGGLAWLGGVLHKPGANRGSEATTSIRENEGEDGAESQGNQDGQSTGAGTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLX6</accession>
    <name>A0A8G1VLX6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_373609</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514824.1">
        <property type="nucleotide sequence ID" value="XM_025656090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLX6"/>
    <dbReference type="GeneID" id="37159492"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.230:FF:000002">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="236"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH56902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="741" mass="83821" checksum="16F0C2A8A25D9907" modified="2022-01-19" version="1">MSHCSSAQRLVGLRCRRALGPSFRSFCPRHPNRLLHRQLLAFRLPPTCASSSSSSFILPPRSFSTSLPRTRHHLPQPSSKKKSTKMASLSTKTGQVVDRSVLDSMLRRRLFYTPSFEIYGGVSGLYDYGPPGCAVLNNIVDLWRKHFVLEEDMLEVDCTMLTPHEILKTSGHVDKFADWMCKDPKTGEIFRADHLVEEVLEARLKGDKEARGQKVEVDEEKEAKKKKKVKQTKAVKLDDAVVKEYEETLAQIDNFDGPELEKIIAKYDIRNPTTDGNLLPPVAFNLMFQTSIGPSSNMPGYLRPETAQGQFLNFQKLLEFNQQSMPFASASIGKSFRNEISPRAGLLRVREFLMAEIEHFVDPQGGKKHARFEEVKDVKMTLLNRDIQLSGSTKTEEMTIGKAVETGLVDNETLGYFLARIQLFLLKLGVDPKKLRFRQHMANEMAHYATDCWDAELQTSYGWIECVGCADRSAYDLTVHKNKTGAPLVVRETRAEPLKVEEWQIDLDKKKFGPRFKKDGKTVTAAIDALSQELREKLSLDLEQTGKIEVEVEGVAGGKVELDKELIKIEKRTRVENVREYTPNVIEPSFGIGRILYSMIEQVYWSREGDEARGVLSFPPAIAPTKVLIVPLSTHQSFAPLVQRLTTKLRRMGVSNRVDDSSASIGKRYARNDELGTPFGVTVDFQSVKDNTFTLRDRDSTKQVRASEDEIAQAIKSLVEGEETWEDVRKRLPEFTGQEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMW9</accession>
    <name>A0A8G1VMW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_486768</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517073.1">
        <property type="nucleotide sequence ID" value="XM_025663404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMW9"/>
    <dbReference type="GeneID" id="37166806"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="296"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH59151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="673" mass="75398" checksum="4A5BBB82D05BA7E6" modified="2022-01-19" version="1">MSGMGHMSMGDGVPGLFYLQKMYWAVVGSAIAAGTVINILNRFLAYQRLKDSSLTPSKPKTIFFSTYATLTAIVREASYATLPQLSFRGHSYHFAPLGPVSIILANLIVVLVFCFYKLDTADQWKWEDVGYRTGFIAICQLPLIFLLAGRQNLIGMLVGMSYERLNWFHRWIARTLWLTATIHMCFWFRDWGRYNYIVYELKNYTLATRGFAAWIILTFILITSAAPIRRLGYEFFVLQHLVTFVGFIVAVWLHAPAEVKVWVWIPIGFLVFDRVARYLWATYANLSIFHRSKSPAHALWANRATFTPLPGNVTRIAIENPGVGWKPGQHVFLTCHSIVPLQSHPFTIASIPEDNKMVMYVRAEKGGTRRFFRYASKNHQVLGASDQVAVKQARTVFIEGPYGQMRPLKQFDSVILLAGGMGATFTVPCLRDIVAKWKAESTARLAATKRIRFVWVIKSRTQLSWFDRQLQEVLRDVEDVRLANPDVIREIEMSIYITCDEKLEQAQNTLCAQEQSLFQLQSSLPANEKSLEAEKAATDAVAIESVEQSGCQPDGTCCCTAPIKDEDAIDATTCTCSGHAAPQSTSELATGSDSKAMQNPLPNLTVLSGRPHARTIIRKVLEKAEGESAVVVCGPRGLSDDVRRSVVCLSDERAVHKGTGAQGIYLHVEQFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMY8</accession>
    <name>A0A8G1VMY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_420905</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516157.1">
        <property type="nucleotide sequence ID" value="XM_025657909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMY8"/>
    <dbReference type="GeneID" id="37161311"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000018">
        <property type="entry name" value="39S ribosomal protein L46, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="10">
        <location>
            <begin position="598"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH58235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="869" mass="99093" checksum="5CDA4E20C7373373" modified="2022-01-19" version="1">MDISAQTFFYHLPRVLDDLASCCFVSIDFEFSGIAKGLGPSPKSRSTLQERYEEVKNSADQYQILQVGLTICHEDPETETYTLKPYNLYLSPIIDRKLDLDRNCSFQSSAVEFLLENKFSMEELYKNGVTYLSRDEESRIMARVMQRNERTTARSSLDVADHEHESIAFLKDARRLVDDWLALGKARDNYLNIPPPRPINGPAPPNHPKSMPTDLNRFQKRLVHQLIEVEYPNLVTVSKPGFIQIIDYDEQREKAVRDQRVKWVQERIWKQTGFRWIAEALAGGDLTNLEPFCFINLMSSSKENPQSSLQDFSRRVKQRLQKNRPILVGHNLFTDLIYFCRCFFGPLPDRVEDFQAMAHKMFPVLMDTKYMATHNCGSINPRSSLQEINDSLAAQPTPAISIHPQFTKYNTRAIDHEAGFDSLLTAQVFIKLSAQLRDRGTSGIPPTIPEMPQPSEKSKEPTKQVIGDFEATVVLPRGPKSNNVRIMFGSIEVEKVVQDNGGKDAGEVTRISLTPHDSPETQKKADEGRLIPRLGAQFWEIYGNKLRVFGPAISDPRVCRSCQETLVRRNYATASTQASTETPSTAASAFPVVKPTHTIKAGVVLSRPPQITRDLTDFEKAYYFYQKRLNERLQLPFTKYFYFKRGTPADEDWKRKIRERQTPARDIGKYNPYSKEAWNDELLVGAVESDPAHQVEMLVQDAESTVNATSQDTSKKEEIPRPFPRVTEADQKNDQRSLNRALQRTLYLLVQSKDGFWTFPSSPIVAEETLRQAAERTLEQAAGVNMNTWMVGYHPVGHYVYNFRNPSKLATGPAGEKVFFMKSRIMAGQADLSGNAQNLTDFKWLSKDEISKFVKPQYYASVKNMLADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN09</accession>
    <name>A0A8G1VN09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_512292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517326.1">
        <property type="nucleotide sequence ID" value="XM_025664648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN09"/>
    <dbReference type="GeneID" id="37168050"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="326" mass="36492" checksum="994CE8EE73E98E9C" modified="2022-01-19" version="1">MEFMRGDINEFIDTIAGYKSTISVGLGTITIHSSKVPQKVLEEYNEMIQDTAYNLELHLRRIDEKLAQLTTEEINASDISLNLEDERDVTKQCLRVCEDAKSYIESLETRESAILSNSFGSATENDMQNMFEAQFLTRQALEKNRDSFAEIIGHLQKRLESQVLSGSKNEKERLGLQEDIQTSKQCLEVCKVASEISCQKIFRIGEVVADGDSDQVVVTTLADLFDIRKAQSKGNSAQLVGSMTEEALRHLTEKRYSSRFAALDTRSADVVSTSSPSVLETRRGDYSAGTSDEEQNAVPMIRRNKPSPNEMRKRAMASGAKSKHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN85</accession>
    <name>A0A8G1VN85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF962 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_450470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514375.1">
        <property type="nucleotide sequence ID" value="XM_025660382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN85"/>
    <dbReference type="GeneID" id="37163784"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="189" mass="20763" checksum="0C977C12EB4C1CA4" modified="2022-01-19" version="1">MALNLEKQLLFYGAYHNNPVNVAIHITCVPILLFTGIALASNTPAFVNLPDALQIQNLPPNLGTIAAIIYSTFYILLEPVAGALVAPLILAGAAWANHLLATYGNSVNYWFAGIHVVSWLAQFVGHGAFERRAPALLDNLVQALLLAPLFVWMEVLFFFGYRPELKARYDQNVEKQIAAFKAQKGKTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VND8</accession>
    <name>A0A8G1VND8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable lysosomal cobalamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_460527</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family. LMBRD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514525.1">
        <property type="nucleotide sequence ID" value="XM_025661722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VND8"/>
    <dbReference type="GeneID" id="37165124"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050854">
        <property type="entry name" value="LMBD1_LysCbl_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130:SF2">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="570"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH56603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="598" mass="67257" checksum="B549C54F0E770154" modified="2022-01-19" version="1">MALLQTSLIWAVYAIVVAVLVMVASVFIYTYQTPRDRSSVVTFTCIVAITSLLATVLLLPVDVALISSTTSSKLGQRKPWATQDEVDKIVSLLTAVYYLLYSLDAFLCLLAIPFVYFWYEEYDEVAVESGEQSAAKRLWTAFKYTISFIAIVVVLFIVGFLVPVSNIKDSNFSDYLRKLLAENRGERVITFTLGLLITLGLFLYVLYTSTGLAVLPMMMIRTAPSVSDMTWKASTGAQLESNRERQRQLEGRCRGDPGLLSSKERRELDTLVRDERTLIRRQRLAEEADGEGRGRFMRAWLKITAFFRPLKLLGGIAILLVALMIWISMLLTAIDKAKNSMCKQRCGYILSRIGVFNPMNWVFVQSARVFPIDYAVFTVVVLLLFGSSVVGISTIGIRFLWIRIFRIRMGHTSPQALLLTTAMLILTILALDYSIPMLVAPQYATFGPQTFCDRPPGQQSDCLINKRLIKPCSELTDNTAAKQVCTPSVTSMFLNRVTISYPFFGTVFFWSQFIFLGKWEPPVFIKSSHRLMRSKISGVYLLVLVTSFIRHPKLDERLLDQEAEEAEEERLLASSGRGVSDTYHSVGGGNNFPTRAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNZ0</accession>
    <name>A0A8G1VNZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_222009</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518168.1">
        <property type="nucleotide sequence ID" value="XM_025654711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNZ0"/>
    <dbReference type="GeneID" id="37158113"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF37">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="607"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH60246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="728" mass="81324" checksum="46E09E6DCD3B6048" modified="2022-01-19" version="1">MTSRGWRQLLSRSIIAMLPPFNFLTLHYVYFIATSLICSVIFWGSSTPRRSVSYTDSLFLCISAMTGAGLNTVDLSSLNSFQQSILFALLLLGHAILISITVLFVRMGAFQAKFKGISLERARKAFEQQGILHGRAHKVEHQAISLQCAREALGQQLVGDDTKAYDHQPQSTSLEPILEHYQLAKLDGATVDVKHAVTAGAAPAGNCDSVRSDDQIQWVDDDQVTLSHMRARQKHHHHHRVFPMVGVGARLDLNNHPRDAAPIMAHNDEETDLPALKGLIKGTQKYFRSKGSIARNSQFHGLTPEERERLGGVEYKAVSLLLVIVALYWVLFLLCGIIGMGTWIAVSHPDIPRANGLSPFWTGAFFAVSAFVNSGMSLLDANMTAFQTNAYPLLTMAFLILSGNTLYPCFLRFIIWAMRCVIPDKPSWATWKVTLDFILDHPRRVYTNLFPRRHTWYLLGTIIILNAIDWAGFEVLSIGNKEIESLPTGYRVLDGLFQACAVRAGGFYVVTIANLRQGLLVLYVLMMYVSAYPVLVTMRNTNVYEERSLGIYAHDNTDDETEEKTSPNMFIQLVRHHLLGRQDASTPEASRSYFVHQQLRSQLSHDLWWIALAVFLIAIAESGNYSRMPVAYSTLNIIFEVVSAYGCVGISVGFPSSNASFCSSWHTISKLILAAVMLRGRHRGLPVAIDRAVMLPNESLEWAEEEDAAMRREQSRAWGSDKMPIGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP04</accession>
    <name>A0A8G1VP04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_228259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518391.1">
        <property type="nucleotide sequence ID" value="XM_025654760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP04"/>
    <dbReference type="GeneID" id="37158162"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="367" mass="40071" checksum="5420AA92251733E1" modified="2022-01-19" version="1">MCPMLLNGLSDGPAMVLSPPQDHAFVQFPRQPKFTHDTESRSFFSNNNNPFQPSRPSRKRSRDEDSFEEAMNGSSTPMSIVAASAPQPRKQEVEEPIYGEGMVLLNPRTKMAISAESQTGTWYEETVENVTTAAPVSSRRSGSPSASRKAQRLDPAASNFDDITLSSIQRKINTEHQDDNRRILNAGNRSEEPTVDDATRLLGISWQRIATDDADMAAAVRGWKKYIDRQFATYLADSQILLKNRALNAYLVTARPMTPMGVSPTPAFYLFNDDLSQGQLVGSTWEACLMNLRSSPIVFEGTQILNAADRPLNNGMASMGAQNLLGANQVDSGLPLLQTLCAQPVNHGNGMGLNNSVGMGTGMEIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPM3</accession>
    <name>A0A8G1VPM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_251335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517764.1">
        <property type="nucleotide sequence ID" value="XM_025654935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPM3"/>
    <dbReference type="GeneID" id="37158337"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="66" mass="7381" checksum="D5DA222270D704BD" modified="2022-01-19" version="1">MISGPHAGFHYCSCELKSREPSCHQSSGDNSGHGVLFFVFPSFCFLPTYLPTCPLTTYDRMDIVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPN4</accession>
    <name>A0A8G1VPN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_456751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519081.1">
        <property type="nucleotide sequence ID" value="XM_025661469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPN4"/>
    <dbReference type="GeneID" id="37164871"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010775">
        <property type="entry name" value="DUF1365"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973:SF4">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07103">
        <property type="entry name" value="DUF1365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="432" mass="48606" checksum="9E814CB65B020848" modified="2022-01-19" version="1">MLDCTGSFVSICIRLRDEDYPYVFLLTAPKVLGHVFNPVSFWYLYSINKTLATVILEVNNNFGERHMYLLLSTGSTSGGTSVADPADQPCHTLNHFSSIWSKDFHVSPFNPREGMAYTLTTADPLRCERPIDSRIVLVASNRVRLIASIRATGPAIRPAALSAYQRSQLILSWGWVGALTEPRIYFQAAMLHVQRKLRVWSLPVPLEKTISRRANRLERSLEYFVRGYLRHRVENTDGSFTVRYSAAGLFANDAVEIMQSPSARAVSSKCPDKAVGFRVLRPDFYTSFVESQALTAEEVFKLLAGHDFLRVSRMNVLRDLFCDESGSFPELAKLSRPGCLAFRIIAWFRKGRPAASAGLRSLSALDYYVLTSCSPAEQRHYWMQVMKLFLSRYFAFGHVPLFEVEVLVALLAVGWGLLATLSLVYSPDDTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPQ8</accession>
    <name>A0A8G1VPQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_518696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517869.1">
        <property type="nucleotide sequence ID" value="XM_025664988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPQ8"/>
    <dbReference type="GeneID" id="37168390"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="523" mass="58809" checksum="C938674EDA796F6B" modified="2022-01-19" version="1">MLPRNIHPTGFPSGDKPDGPNTLERNFPSHPPPFPLNTTIEFKFKTASGPPPSLAEDTLTGNANDCLPKVDPNSGFVSHSKEDGITHTTANDAKYLPRKRHWGHHIPPVGDIDMVEAFIAQKECHEQQKLIAIDRHKVHKLRAMMWEQREEETAVRDSIRAHLSAITCCTCRSTAQLIEKDYAALRSIALYHLDLEYQLNQSEDELEELEQELARSAARLSRLFHPVDNRGLQGVRTELGAARSSSDPRGFYTRSVLLTTSERKNDLQQQQPHLFTSQVQESISGAERVPVSQTSTRPVSPNYRFPQAWDRIEAQPCLDIADFESDLDELAQSDPGFARGTAHSLGIRSRSADDIRSADGQIKDPFKLTTRERSSPYDQNDFDSTGPPFQRRKFIDNRILHQVRTSSLESARLRSHPVWETLRTQGLTDEDISQLALGSWHSNDAGAVVSSGSTIKPSKKLEQASTVIWRGTCRSFNNRKRTNSIAFGTRPPLRRMSRYDSAWRGFGLENEGSQPADLAMKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPS7</accession>
    <name>A0A8G1VPS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_188132</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519038.1">
        <property type="nucleotide sequence ID" value="XM_025654409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPS7"/>
    <dbReference type="GeneID" id="37157811"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000004">
        <property type="entry name" value="2-amino-3-ketobutyrate coenzyme A ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="251"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="675" mass="74215" checksum="FB5DD52DC86F4654" modified="2022-01-19" version="1">MPRRAASSFVNDPSNVPSSSASAKGGIAIKASAVKPNRLSQLFSTSPKSKAESQTAQAAVQSASGILNSSTATPPISSASLSLPTISLSTATADNPNMDEPPTTLFQPPSPEEARRLAKQHAQFGPIGHHSHRYTSQHPGGTFPEPVMDEPPYYYLLTTYISYLILIAFGHVRDFFGKRFREENYRHLKPQNGYGALNSDFDNFYVRRLKLRINDCFERPVTGVPGRYITLIDRATDDHNKHFYFTGTTTDTLNLSSYNYLGFAQSEGPCADIAEDSIRKYGIVSPSTRAEVGSQDLHVEVEDLVAKFVGKEASMVFSMGFGTNANIFPALVNKGCLIISDELNHASIRFGARLSGASIAMFKHNDMRDLECKLREAISQGQPRTHRPWKKILVVVEGLYSMEGSMCNLPGLVMLKRRYKFHLFVDEAHSIGAIGPKGRGVCDYFGIDTSEVDILMGTLTKSFGANGGYIAADKAMIDVLRATNSGVFYGEAPAPAVLAQIMSALRIINGELIPGQGEERLQRLAFNSRYLRLGLKRLGFIVYGHDDSPIIPVLLFNPAKMPAFSHEMLKRKISVVVVGYPATPLVSSRARFCVSAAHTKEDLDRILTACDEIGNVLQLKFSTGIAGGALPEDAMPPPEKEQELHRKRNSKIIPPRWQIEDVIRRGVQDVKSPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPU8</accession>
    <name>A0A8G1VPU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small nuclear ribonucleo protein complex protein Nhp2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_446493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519261.1">
        <property type="nucleotide sequence ID" value="XM_025659514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPU8"/>
    <dbReference type="GeneID" id="37162916"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000027">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="3">
        <location>
            <begin position="99"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH61339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="233" mass="25123" checksum="5F954AF767AFF42F" modified="2022-01-19" version="1">MAKERTEKKDKREKKEKRAEKDGVSKTSKKEKKDKKDKVALADAVEKELTTKVLDGLDQAAAEAPVNGAETERMDVDSRPVGAVVPFASPLVEDKNAKKVLKSVKKAAVNKCLKRGVKEVVKALRKSPIPAANASIGVPNGVVILAADISPMDVISHIPVLCEDHGIPYVFVTSRAELGNSAATKRPTSVVMVVPKSASKGKKKDGEDDGEDFTEVFEELAKLAQKEAKKVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR64</accession>
    <name>A0A8G1VR64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_476164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517390.1">
        <property type="nucleotide sequence ID" value="XM_025662763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR64"/>
    <dbReference type="GeneID" id="37166165"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="166" mass="19295" checksum="013FC8A34DD31405" modified="2022-01-19" version="1">MQIKLYRSLYTAIDMHFHQLLALITSTLITAAAGGQSLLPEQLFFDFPVAEVLNRTAWDLVEPWATEYCTAIAEQRYGDAIYARYNIFGDIKDGMLTLWDCTDEGPYRERNITVYEQIMEDARGYYDGYQDIYQEALEFYSRNSPNDSRRDIIEALNNVMYNGSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRD7</accession>
    <name>A0A8G1VRD7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Transaldolase</fullName>
            <ecNumber evidence="3 9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_455000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 9"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520866.1">
        <property type="nucleotide sequence ID" value="XM_025661358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRD7"/>
    <dbReference type="GeneID" id="37164760"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH62944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="324" mass="35398" checksum="F6BA93C7E7F3CAEB" modified="2022-01-19" version="1">MSSSLEQLKATGTVVVCDSGDFATIGKYKPQDATTNPSLILAASKKPEYASLIDAAVAKGKAEGKTLDEQVDATLDRLLVEFGKKILEIIPGKVSTEVDARFSFDTQASIDKALHIIKLYEENGISRDRILIKIASTWEGIKAAQVLQSQHGINCNLTLMFSTVQAIAAAEAGAYLISPFVGRILDWYKAAHKRDYTAEEDPGVKSVQSIFNYYKKHGYKTIVMGASFRNTGEITELAGCDYLTISPNLLEDLFNSNAAVPKKLDAANAAGLDIPKKTYINDEALFRFDFNEEAMAVEKLREGISKFAADAVTLKDILKQKIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRE4</accession>
    <name>A0A8G1VRE4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_464835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520763.1">
        <property type="nucleotide sequence ID" value="XM_025662013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRE4"/>
    <dbReference type="GeneID" id="37165415"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055530">
        <property type="entry name" value="DUF7104"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF78">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23397">
        <property type="entry name" value="DUF7104"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="66"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="966"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1017" mass="113704" checksum="ED42C45DF07BDBD3" modified="2022-01-19" version="1">MSPELARNPVLTGPAFTYTELPRESPHPTTRMIRLLPNKDKAAQIECEIFNYEFILDTSGGDSHIYEALSYVWGSGTSSRTIILNGCRFPVTENLYVALSYLRNRQLERIVWVDAICINQSNRDEKAQQIPLMREIYAQAQHVIVWLGEAYDDGDRALEGLRCLVEGQDIDIEGCGKLCVNLFQRAWFRRIWVLQEVGVARFIYIMCGSVQINGHILCEGLNKLSLPPKDQDMIGPVVFLIKGALFRPRYEPMSRGTLTIGELVGMYCFHDATEQHDKVYALLGLSADPMTPALTPNYDFPWNKVFKQVTNHIFPKCSVETWPESDIAIIRGMGWALGHICSVRHVSDFGQQKVKMYLNDTAQLVGYQSDWETDWELQTFAQFFEPGDIVFLLHGASRPSIIRLCRDHFRIITPAVTLRKRRPRESLEGTSRGWHTPGGFFDILLAWRIPLNNDTRSQKWPETELPDMVPAYQEQSFEAEYRRSNITRIMVGVAMEALALEKPENEDIAHLLVSSGTDNTTASKLTKASGEDIRSSSDKILQSFFQSEQDDVSISQDMVKAVAENYGPCGYIIMELLFQLQGSSLPISEEVIEAAAGNFGKYGDQVMKAIYRHRGEFFPISEEVVKAAAGNTGRKATKILKLLFKAQGEAIPISGEVLKAAAANRSTHGFEILKIIVHHRGQNLPVSEDVIINAIENDEWGYDNIHYLFECCDRKVPLFEELVKAAAERDVTFLRLLLEQGEESLLVSEETVKAAAGCVTGNESLKLLFQYGEKSIPISEEVIKVAAGNEMYENRILEVLFQYAEGSLSISEEVVKTAAQNEGSGTAIMKFLFQQKGDKLPVTEEVVKAAAGNEGCGHDIIELLLQQKKRSGLPVTEEVVKAAAGNMRRGFVIMGFLFQQKGDKLPVTEEVVKTAAGNPWYGYLIVDLILRVRGNNLPVTEEPLEAAENTRCRATILEILQPKRSLQTTVTESPEVPEISESAESSDSPESLEDPPSSESPESSESSLSSDELDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRJ1</accession>
    <name>A0A8G1VRJ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_410447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520898.1">
        <property type="nucleotide sequence ID" value="XM_025657482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRJ1"/>
    <dbReference type="GeneID" id="37160884"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08577">
        <property type="entry name" value="PI-PLCc_GDPD_SF_unchar3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039559">
        <property type="entry name" value="AIM6_PI-PLC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF5">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34403" checksum="138C2E928CD907DA" modified="2022-01-19" version="1">MVHTRSLAVAASAFLLGDPRLAAGGSTELQSVLKNTHGSNDYGYPTDFTRGIMPIPVHSHNDYWRDIPFYTGLSKGCISTEADVWLYNDTLYVGHDESSLTKDRTLESLYINPILDVLKLQNPSSPFVTTPTNNGVFDTSTSQTLYFFIDLKTSGPETLNAVISALQPLRDQGYLTTLKDNSTITTGPVTVIGTGNTPLDMVGPVADRDYFYDAPLEALAEPEYADITDLISPIASTNFAAAVGPVKGEKLSDKQIKALREQIQTAEERGIGARYWGTPYYPIRTRNFVWRTLLEEGVGLLNADDLDAVVEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VS55</accession>
    <name>A0A8G1VS55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_433177</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520479.1">
        <property type="nucleotide sequence ID" value="XM_025658412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VS55"/>
    <dbReference type="GeneID" id="37161814"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="81"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH62557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="708" mass="77899" checksum="17045A4617F88778" modified="2022-01-19" version="1">MLFSQQPLHLTRADELRQSPPKGTPYSVALPGTEKPGRSKVYRAWNATESVLKSLDPQILTAHDIFESTANRLPKNHCLGWRPYNPTTKTYGPYQWLDYQTVQKRRAAFGAGLVELHHKHECSRPGQYGIGLWCQNRPEWQITDLACMSQSLYSVSIYDVLAPDATEYIINHAELACVVTSLPHIPTLLRLKPQLPNLKIIVSLDPLDGGEEAGHSKRALLESMAAGQDVSVYTIGQVEELGASVDRPCKPPAPSDTITINYTSGTTGPPKGVVLAHENAVASASGALINSIQKPGDTIISYLPLAHIYARMSEHAAFWAGARIGYFHGNILELVDDLKLLKPTGFISVPRLYTRFGNAIRASTVEAPGFRGALSRHIVATKTANLKNPDLSKATGKHALYDRIWAKKVAAAIGLDRTRMLASGSAPLDPSLHQFLRVALGVDVVQGYGLTETYAMACVQSIADLTAGHCGGLIPSTEACLVSLPDMEYSVDDKPYPRGELMLRGANVFREYFKDPEETAKAVTEDGWFRTGDVCKIDEMGRIVIIDRRKNVLKLAQGEYISPERLEGVYMAEMGYLAQGYVHGDSVQTFLVAIFGVQPDTFAVFASKVLGRTIEATDIEGIKSVLSDTKIRKAVLRDLSRIAKKHKLAGYERIKNCALMIDPFTIENNLLTPTLKLKRPPTTKKYRQVLDDLYAEALAEEHAPKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VS59</accession>
    <name>A0A8G1VS59_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_482470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520494.1">
        <property type="nucleotide sequence ID" value="XM_025663101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VS59"/>
    <dbReference type="GeneID" id="37166503"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="121" mass="13327" checksum="96C0F9BB27A68789" modified="2022-01-19" version="1">MARHTSLESERPIMAQSARTSKRFSTVSEAPTVASSETTFAGLPAGDPRLADFHNLRDGLERLENKPLLKQRFVPTPEKTDDLSKLALGAKVERALGRRMTSQDAVMREPVLNEKAVVEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VS66</accession>
    <name>A0A8G1VS66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_466997</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518410.1">
        <property type="nucleotide sequence ID" value="XM_025662163.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37165565"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000050">
        <property type="entry name" value="GTPase activating protein (Gyp3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000036">
        <property type="entry name" value="GTPase-activating protein GYP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="911"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="960"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="987"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1015"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1056"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1106"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1166"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1197"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="10">
        <location>
            <begin position="428"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="828"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="843"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="876"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH60488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1308" mass="145861" checksum="E15ACEE5005B1E21" modified="2022-01-19" version="1">MVTGNGDIRYPPLAGAHDIPSRRRIPNPPRLDPLRLNPPFPRPSTADGVRPPPSQRPPVPSPRLHPAQVAAADPSWRSPSPQPRDDDYFVPRKPALRTPTFPVSPGHRPGYPSRETEFDRPPPRKLPPGAPGLRISMSTSKLHNRRQRPPRSRERYPDDAYGLALPRVAPPGSYADAHGDDALRSSVNSAMTSRSSIEQASGTERSSVLTKSSSITDLSPDTPDGPYEKDGGMSVEDAISMYLDGFSDVTEEPGTPDIYDDEKVRPWSPCPPTEYTLDDGHTSDEHSPDLDPTEDLPPVPPLPELSAPVRGPLSDRHEGEEVPHEEPPVETPLKSPGVERQERKVVLPGVVPPPLLLGTDSRDRYGFRKATHHVTLAQWEAWNSSYSDFAATQRIKWVELLRQHRLPITDPISFPPKSNKVKKFVRKGIPSEYRGAAWFFYAGGYEHLNRNPGLYDQLVRQAMDSPSNDDKEHIERDLHRTFPDNIHFKPESVEQYGGSSAGAGSSNPKHESVTVETEMIQSLRRVLYAFAVHNPQIGYTQSLNFITGLLLLFMPEEKAFWMLHIISSVYLPSTHEISLEGANIDLWILMVLLKETSPHVYNKIAGGLGGGSRAPALTVTSRLPDITLGLTNWLMSVFIGTLPLETTLRVWDVFFYEGSKTFFRVSLAIFKSCEREIMAVSDPMEVFQVVQTVPKKLLDANTLMDDCFVRRHRVGQGRIDELRAARRAAVRHENMRRSRAWNKGQIQAATDEWPGRSRTPIPGIERKIGDSWRHMRNHAFRLAGFRAQAGWTDDMPDDVTCVFHLRISPFLHLQHATIMSGQASSYYNANQSFGDQPQPQPPQQQQQQQYAYYNYNQAPQPAPNQHNGGDYRGPEPKPPQGPPQGPPPTYNQAVYGFDEAFQVERPKYNDIWAGLLFIAVFLGYVAVSGVTIHRYAKYKGFSGGGIYDATNDFSLNTNTLVLFIFVLCVALAFSYAYFLGARYFSKLFIWVTGILNIVFALATGIYYIVRGQYGGGIVFLIFGVFAIVCFISWIPRIPFTAYMMEVSIDVSRQYGHMFLVSTIGGLVAVAFAAWFSVTLVSIYVAYEPDSTGVNPACPNGSGGCSTARVIGLVVYVTFAMYWFSEWLKNTVHTTIAGVYGSWYFFANSPQGMPHGATRGAFRRATTYSFGSISFGSLILAVIQMLRQACSIAQQQEAAQGSIIGSIGFWVLGCFISLLDWLVTFFNRYAFCHIALYGKAYIPSAKDTWKMMKDRGVDALVNDCLVGPVITMGSVFVSSRTPGITREGTSRRSLWRLRLSLDCRSVRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSH0</accession>
    <name>A0A8G1VSH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_454977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520839.1">
        <property type="nucleotide sequence ID" value="XM_025661356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSH0"/>
    <dbReference type="GeneID" id="37164758"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="546" mass="62144" checksum="1D524BFE896EBD80" modified="2022-01-19" version="1">MSVLDFPDYPDGDVKLTIHPDGYLLHSNRLCEHSRVLRGLLGQPDEVQPVPHIQGMDHLGVSNLYLIGEAAHKFGVFQLQASRRLMIRVPRQFTSEIRGFQAVDYIPVWPMKTRRCWENIFRMFYLLPPILHDDGPEKNFLDNSWRVAELASEIEAGDYIFPILGAALEGYEQELYYSISNDPIGWVNLAIRIQSPTIFREGIIHIVGRWNYVTDEGHALLPGQIRELCERKHRDLQFDKRMIEMNILNHPVADPHDRDIYMWMAKAFHQQWLGNSIAGNQTYRSLDGGAAFYRAINAGGDAYLPVLDPETNLILLPIRQDEITIVENRLNVLKNSVKHLVDNLLRNRSRFNPLVWGDLHYLTCCEVNQHGIPWLAGRAAQDDVALMHTVNPALPLMYRDNIQTETRQIHTPRMPQIVVENPLPENNPQIGTRRFVSPYAQSLERSPDYSSSQSRSELTYAVHEPDLSSDDSQSSFISPPHWDEEDGSTARTDTENPVILAFDESIHTDAQIFSGGDIDLVNDASPVFMSLNGNVEGHGHNTQHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSN7</accession>
    <name>A0A8G1VSN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_435322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518920.1">
        <property type="nucleotide sequence ID" value="XM_025658517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSN7"/>
    <dbReference type="GeneID" id="37161919"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="199" mass="22509" checksum="2FC813CFCE311517" modified="2022-01-19" version="1">MAVTAIDIMPKKPSSSPLSSNNPSMNKRLPPLADRTSLSYKLTTLSRQKLAREATAPDPDIRRCLGHFRLHCMSMEWTQKDMSTRINSFDLEDDESESEEEDRDDEDKKGPEDRKDEDQDRQSSPKNNESAEKTSEPEKTTVQVTFHVSAPASAPQTSTDKEEKEESLLEKGRNCLEKTVQRKNFWPSPGQCLPVRIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VT79</accession>
    <name>A0A8G1VT79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_474179</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519460.1">
        <property type="nucleotide sequence ID" value="XM_025662654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VT79"/>
    <dbReference type="GeneID" id="37166056"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="12">
        <location>
            <begin position="16"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="9">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="250"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH61538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="309" mass="32902" checksum="1D03FA3F6F833A6A" modified="2022-01-19" version="1">MASQQNGDSNGTANTFTLKAGLAQMLKGGVIMDVVNAEQARIAEEAGAAAVMALERVPADIRATGGVARMSDPGMIKEIQKAVTIPVMAKARIGHFVECQILEAIGVDYIDESEVLTPADDVYHVTKHNFKVPFVCGCRNLGEALRRISEGAAMIRTKGEAGTGDVVEAVKHMRQVSSDIARARAIYQSSADYEPELRQFARQLEVPYELLRETAEKGRLPVVNFAAGGVATPADAALMMQLGCDGVFVGSGIFKSGDAKARAKAIVQAVTHFRDPKVLAEVSEGLGEAMVGINVAQMSEADKLAKRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQ71</accession>
    <name>A0A8G1QQ71_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_409304</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825093">
        <property type="protein sequence ID" value="RAH51808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509730.1">
        <property type="nucleotide sequence ID" value="XM_025657430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQ71"/>
    <dbReference type="GeneID" id="37160832"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034345892" evidence="5">
        <location>
            <begin position="21"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="551"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="596"/>
            <end position="597"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH51808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="615" mass="67597" checksum="33E6347286C17E86" modified="2022-01-19" version="1">MSFLTTCIFVLLAIATTALGFSGDYLDDAEQGVPGLDASFDYVVVGAGAGGLTLAARLAQHRYRVALVEAGGFYELKYPLAAVPGAGIIGIGSDVNSSTPVDWRFVAYNVPGANYRDLHYPRGKCLGGSTGSNMMVYQRPNREAMQRWAELVDDNSYTFDRILPFFQRTANFTPPNNDIRHSNATAAFNPSAFDERGEPLQVSYPDFAVPFSSWIKRGMESVGIPKIEDFNSGFLLGAQYCALTIDPHKKIRSSSEAAFKSSSIPHLMTLALYKKTMAKRILINTERRATGVEVRTGDLIYILRATREVIVSAGAFQSPQLLMVSGIGPASELKEHGIEVVVDLPGVGQNMWDHAFFGPAYRVALPTSTRIATNFLYLTEVVVQYLANRTGPLTTQGIDFLAFEKVPDELRSHFSDETIRDLSWFPPGWPEIEYIPVALYLGDFSDPIKHQPQDGAQYASIAGALVAPTSRGNVTIISDDTDDLPIINPNWLATKTDEEVAVAIYRRNREIFQSPGMEPIIDGKEYFPGEEFQTDSEILDVIKDTLMTVYHASCTCKMGVRNDSMAVVDSQARVFGVDGLRVVDASAFPFLPPGHPQSVVYMLAEKIASDIISWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQD9</accession>
    <name>A0A8G1QQD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase UcpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_463934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825085">
        <property type="protein sequence ID" value="RAH52346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510268.1">
        <property type="nucleotide sequence ID" value="XM_025661953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQD9"/>
    <dbReference type="GeneID" id="37165355"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF12">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH52346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="257" mass="27525" checksum="2AF81944AEFAFF90" modified="2022-01-19" version="1">MMLEGVAFITGAASGIGKATAYALARHGVRQLAIADVHFTATQETAQDIEARFSGVRALPLYIDVTDPVSIHEAVSETVKQFERIDYAVNSAGVAGSMAYSGDHDIKDWEKTLGVNLHGVWMSSREEIKVMMGQEKRGDSPRSSRGVIVNVASAYGLVATPVNIPLVSYTAAKHGVVGMTKADAIIYAPLGIRINAICPGYVQTPMIDQMPDEVMQKEVARVPVGRLADAEEIADTITFMLSPMSSYMYGSALVVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQR6</accession>
    <name>A0A8G1QQR6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Inactive metallocarboxypeptidase ECM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Inactive metallocarboxypeptidase ecm14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO85DRAFT_385255</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509840.1">
        <property type="nucleotide sequence ID" value="XM_025656587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQR6"/>
    <dbReference type="GeneID" id="37159989"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000060">
        <property type="entry name" value="Putative metallocarboxypeptidase ecm14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF147">
        <property type="entry name" value="INACTIVE METALLOCARBOXYPEPTIDASE ECM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034739533" description="Inactive metallocarboxypeptidase ECM14" evidence="18">
        <location>
            <begin position="21"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="19">
        <location>
            <begin position="199"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="556"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00026213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RAH51918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="619" mass="69750" checksum="8286EEB0FBC6C47F" modified="2022-01-19" version="1">MRHLLSLLVLLIASAALVSAVPAGSIITPQPPVEPVHLLSSQPADPRRPWTRLRDWVIESIWGIEKPASRRFPLNDSPRNRSPPSRILARYGSDVVLRFSLRDHDEAEALAQAADILFLDVWASTPAFVDIRLAEEVIPSLLGLLPNSLQTAYTPLIENLAERIYTTYPSKRPIGLEGQSGFAPSNRPAPKFGDLFFHEYQPLSVIVPWMRLLASMFPSHVRMISIGVSYEGREIPALRLSAGSSTAASGPRKTIIVTGGSHAREWIGTSTVNHVMYTLITKYGKSKAVTRLLQDFDWVMIPTINPDGYVYTWETDRLWRKNRQRTSLRFCPGIDLDRAWGFEWDGGRTRANPCSENYAGDEPFEGMEAQQLAQWALNETQNNNADIVSFLDLHSYSQTILYPFSYSCSSIPPTLETLEELGLGLAKAIRYATHEVYDVTSACEGIVTSSAADTNPGRFFPIGGNSGGSALDWFYHQVHATFSYQIKLRDRGSYGFLLPSEHIIPTGKEIYNVVLKLGSFLIGGDSFDVDWESELFDLSKEESDLDTRYSNSNYRSPAYLHNANDTVPHTGEDEDEDEDADEDEEWVMVEEEDFADDDEEEKNDAYWATEHTYEFRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRD9</accession>
    <name>A0A8G1QRD9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase Rv2170-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_482087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510146.1">
        <property type="nucleotide sequence ID" value="XM_025663087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRD9"/>
    <dbReference type="GeneID" id="37166489"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053225">
        <property type="entry name" value="Acyl-CoA_N-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="GCN5-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958:SF6">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCN5-related N-acetyltransferase Rv2170-like" evidence="2">
        <location>
            <begin position="372"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="518" mass="56350" checksum="1ABF9AFD93A6ECE9" modified="2022-01-19" version="1">MPATPLTRMSTATRDHAQDKADPILHQACRFDETSPHSEWTQTQLLPLLRSHLPHSLPLLRRIQHEIAHPSPTAVILTTFSGPASSSASLPVSPSASGESIPELVSNPGLVSVPGPRVPDTATPLAPDTAVPAAPSDPESFLPWLIAYVDLNAGRENQVMVYSSLERTASIPCTSTSTSPEASSPKDTSSSDRDDSNTIPITTLPPQHHPLLRTQFLSLLHHIKQHLLPPYLTTLSQSPSTQTQPQDHQLPPPPPTAFLFGNLHTGLFSTLLNTNTSYSLAQATSPADFIPGIKVHRFSQPAYVKYLLPKEVICHQPQDKERRNLPPGFHFSDGCIPRKNLGLVRSRTVIPRSEGTLAKLRSCAVYRDGDVTQTPVAWAFLGTDGTLATLHVEEEVRGLGLAGAVGREVMRRGIEEDEGLKDGWMHSNAAEDNLASRRVMEKLGGRVGWTVCCSYLAREQRSDLSDKAMITGKHFSKRKRPRVDDSGYVATGKRIACPNGASARGLTSLLPVSPKEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRM7</accession>
    <name>A0A8G1QRM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Abnormal eversion of vulva protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_454656</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">GTP-binding protein that functions in embryogenesis, cytokinesis, germline development and microtubulule cytoskeleton dynamics.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825098">
        <property type="protein sequence ID" value="RAH51646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509568.1">
        <property type="nucleotide sequence ID" value="XM_025661336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRM7"/>
    <dbReference type="GeneID" id="37164738"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000981">
        <property type="entry name" value="ADP-ribosylation factor-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045873">
        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9 15 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="8 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH51646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="181" mass="20872" checksum="9C728BC387AF17F7" modified="2022-01-19" version="1">MLSILRKARLKDKEMRILMLGLDNAGKTTIVKQIMNEDVTTVSPTLGFIIKTIDFQGYRLNIWDVGGQKTLRSYWKNYFEKTDTLIWVVDATDRLRVDDCRDELAGLLLEERLMGASLLVFLNKSEVEGCMDESEVRQRLGLDSIKTHKWTILPCSAMTGKNLHKGLEWVVQDAKDRLFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRQ2</accession>
    <name>A0A8G1QRQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable N-acetyltransferase 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_385713</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Probable acetyltransferase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the camello family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825096">
        <property type="protein sequence ID" value="RAH51691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509613.1">
        <property type="nucleotide sequence ID" value="XM_025656610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRQ2"/>
    <dbReference type="GeneID" id="37160012"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF51">
        <property type="entry name" value="N-ACETYLTRANSFERASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="10">
        <location>
            <begin position="6"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH51691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="182" mass="20029" checksum="7C05A406A55D2E8F" modified="2022-01-19" version="1">MTTLPLPTRLATTTDGPQIRDLVESAFRATDTRPNWTGDLALGARFHVTVDDILTRITEEDSAILIATAADVDSNDAPIIACVSMRRHAPGLARLSYLAVNRRYQQGGLGRMILSLAEGHCRDVWGVKRVGLNALDTRLALIRWYERCGYAPTGEVTRLQLPPDVLSFVEMEKGVEGVVRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSN0</accession>
    <name>A0A8G1QSN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibronectin type III domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_472297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510836.1">
        <property type="nucleotide sequence ID" value="XM_025662546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSN0"/>
    <dbReference type="GeneID" id="37165948"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029167">
        <property type="entry name" value="Mug117"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF7">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15474">
        <property type="entry name" value="MU117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034747953" evidence="1">
        <location>
            <begin position="22"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="701"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1064" mass="116023" checksum="5454B7A9CAFBDED5" modified="2022-01-19" version="1">MHTQPWHGLVAIVTIGSCVSASPLAPWELRGNASMQSAHLMGIRDTDDFDPAELSHITKLAAIGDSHSAGIGAGSRLGNIGEALNSKSIISDVINDQIPNLNGDQQVILLSAGGNDAELSNILNQCIYQWAVLNPTQVLVAKAAALANLEYGWMADIDWDALARGCDGQLEHTNRLINGDAFSKSLDNVIAAAKKKLGSNGMIYYTGYAKFWAEDLSPACDKVSWSTWIHDTETLTSAHRKTMNDLVDSVNEKISSAVERAGAQVKFVDYDSYVGYFNGRFCEAGVDESTSDSNTREGLMFYELNTWDPLGSNPHKRSQDRPLEGTFEGSVNEYAEITKLLDPDAQISKQTSVSDDTTDMTLVESKLSLSAVSESSDIEVPNVLPDGYGRVFHPQVQLHELIANLVIYEMTNKNEMDNGYPEIPEKFTFDSCPWTPADVDDDESMDAGGQQIALASYINPLSDPTAWTRMIDYPSDKVTVLVANVLNGPDTTVDEDWEKVISRANAAGKRVLGYVRTGGLADWVSQIQTDVELWYTLYPGMIGGIFFDEGWNQCGDDNVYSDLYRFITDYTKRMHPGAFTVLNPGATMPQCFEHSADTLMTFENSYDTYMNNYSPNPDWTPSDPRKLWHIIYNVPSDSVGKVAELALKRGAGLIHITNDNLPNPYDTLPDDDYMQVIMSALEGGMPAISSPTAYEKNGQSAPAPSSLAVTASDYSSVSLSWGASSPAPYAYSIYQNGKEVARLPGSMTKVTIGNIDHGTSITFTVRAIGSGGSASGDSNSVEATTLELPDNQPVTNVKSSSTATKTTVQADILIPFAFQRVFLTDPDTACEMPAWPINYNLGNYICTHYMVESGTLFKYSGAELPAGQTNYPWAWTSMGTVPISRSGYTWTWELPIGSDTVDTNYFVVEAQGYGPLTNVFHPCPSTWDDATLSSGAYCTGNSPYDCKGATLCSTLNVKWCDKAVNQMNRGSTLYTANAEALALSGNCWANWEQFGCSVKIRGKDENGKDCTITGDEMWEAYQDIRKIGGCKKCGSKHFGNGCLVSVDYYYGCDNRDSGVNAIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSZ9</accession>
    <name>A0A8G1QSZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acid phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_406712</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511031.1">
        <property type="nucleotide sequence ID" value="XM_025657342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSZ9"/>
    <dbReference type="GeneID" id="37160744"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000043">
        <property type="entry name" value="Acid phosphatase PHOa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF23">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034212428" description="Acid phosphatase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH53109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="416" mass="46469" checksum="CA94FF51C5F49A29" modified="2022-01-19" version="1">MFTKQSLVTLLGGLSLAVAQTTTEEYPSLAEIRAAQATVQPYSPVSNVKGLAFNRFVNIWLENTDFDAAAATEHLPVLAKKGVLLNNFWAVTHPSEPNYCASAAGDTFGMDNDDFHQIPSNVSTIADLFDTKNIAWGEYQEGLPYPGYQGYRYPESGANDYVRKHNPLILFDSVTEDALRLRQIKNFSSFYDDLENHRLPQYMFITPNMTNDGHDTNITFSGDWTWNFLSELLENDYFTKDTLIMLTFDETGTYEIGNNIYTFLLGGAVPDDLLGTKDDTFYTHYSVIASLSANWGLPSLGRWDCGANLFSWLAKKTGYVNYEVDTSNLYMNETHWGPLSDDDYSEYYAGWPVPTTDASCSAGNGILSTVKKTYEGLTATFNYTTPFPYDSRSGNNVGVKYSRTLKNGKVESGTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTV9</accession>
    <name>A0A8G1QTV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_504416</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511496.1">
        <property type="nucleotide sequence ID" value="XM_025664300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTV9"/>
    <dbReference type="GeneID" id="37167702"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0779">Telomere</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="45"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH53574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="286" mass="32615" checksum="8EB6C7F0457E9ADF" modified="2022-01-19" version="1">MEEERTMENGPSQAPGYPEALHYRFIPPSLEGLEFVPNFGDIVFRVKGQFLAWGGTAVLERLPSGNVVKTPLPNPYFQREHERHRKSMCIEAIIYEILKDHPRVPKYLDWDPTTCCLTMEYVENGSLADFLERNHQSIADSMRRKWARQAAEGVQLLHHHNIIHSDLSPHNFLVDSNLDLKVSDFAGASVFGAPGSALPGTRYRDPHVEGYVLRSSDDIFSLGSVIYFIMTGKHPYQDLPSDNVKYLFQCSQFPEVGHLSCGSIIRRCWLLEVDATEVYEYFSRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUU2</accession>
    <name>A0A8G1QUU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_502588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511970.1">
        <property type="nucleotide sequence ID" value="XM_025664201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUU2"/>
    <dbReference type="GeneID" id="37167603"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH54048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="362" mass="38301" checksum="87572A5BCE0B567A" modified="2022-01-19" version="1">MSSTKQSRYYADPEKAKEFAAALLVKAGLDSEDARSMAECLVLADVRGVDTHGLARLPQYLDRVSNGRVNARPSIKITNKTPVVAHLDGDNGFGFVVATRGMDEAIKRAGIYGIGMVTVNHSNHFGMAATYVLQALKANMISLVFTNSAKQMPPFGGKETLLGISPFAAGAPSNTEVPYILDMAPSVVAKGKIRRAARRGEPIPLGWALDADGNPTTDANVALNGSMAPIGGPKGSGIAILMDIMSGVLAGAEFGGQVGDQYKDTKPQNVGHCFIAVKPDVIMSTEDFKARIDILAQRVHGVSPAPGFSEVLFPGEPEHRLGLQRRAEGIPYADAEKTLFADAAKQYGVPELPLSDCPLALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVE8</accession>
    <name>A0A8G1QVE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_427394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512306.1">
        <property type="nucleotide sequence ID" value="XM_025658152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVE8"/>
    <dbReference type="GeneID" id="37161554"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="182" mass="20157" checksum="2CB523AD50BD163F" modified="2022-01-19" version="1">MSTEPLLPSYVSATQHDASPHVRRHSARRRTSLVIPAAPVIQTLSGLTFMTTAIISTVWAYRSYVPPPELSPTEPPSLLPYFASLCLTISLGFWVGYLLFILYDGAGGPRMQRKVVIGVSTVGKLVLAGAHIGVWLGYKYLLTGSKQPSWALMFLATQAWWDVLLLVVYSCLRAPVEPRVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWH8</accession>
    <name>A0A8G1QWH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SWI-SNF complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_402689</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512855.1">
        <property type="nucleotide sequence ID" value="XM_025657199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWH8"/>
    <dbReference type="GeneID" id="37160601"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10568">
        <property type="entry name" value="SWIB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000010">
        <property type="entry name" value="26S proteasome regulatory subunit RPN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18503">
        <property type="entry name" value="RPN6_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="224"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="5">
        <location>
            <begin position="744"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="437"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="625"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="929"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="629"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH54933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="973" mass="108885" checksum="D4ADBC31AC9D385A" modified="2022-01-19" version="1">MAPSSTTAGRIDEARGLVKSDPSKAESILKEILAQGPGSSEASSRDYENALVLLGELYRDQKKPHEIAELIKTSRDSFSSFAKAKTAKLVRQLLDLFSEIPNTLDIQVSVIQSCIEWAIAERRSFLRQNLQTRLVAIYMQKQTYYDALTLINSLLRELKRLDDKLMLVEVQLLESRVYHALGNQAKARAALTAARTSAASVYTPPNLQAGLDMQSGMLHAEDKDFNTSFSYFIEALEGYSSLDEGEKATAALQYMLLCKIMLNLVDDVTNLLGSKQAQKYASPRLEAMKAVARAHANRSLEEYEKALSDYRFELGSDTFIRNHLRRLYDAMLEQNLIKVIEPFSRVELDHIAKMVGLDTQQVERKLSQMILDKVIIGVLDQGAGCLIVYDETERDQAYDAALDTIEKLSNVVEELYTNQASLLDNYTPISPALRGLSHRPKDLHPPIRGSSLAASPSHHGPTMNAPIPPNYGRGFPPQAAQRSPATPRRGPPGPAAAMPVPMPQHAVPPQYIPPQRNMQPPNDAALRRSRKPTDKNIPDGIEEVIIGEGVQQYKSLRDLEKRLDAAIVRKRLDIQDSISKTVKKYRTMRIWISNTVENQPWQTANGAAPGSNPGSGRYKVRIEGRLLDDDSDPTAPEDSDDEATEQTDNGDAMEQDGPNANATTKKSSSKRSKQRFSHFFKSITVDFDKSSTASPEEVKPITWTKPQLPPNTVTLPPTADFDSMQFTRASQENLNVTFSLVRDETPERYKLSKELAEVLDVEEETRSGIVLGIWDYIRAMGLQEDEEKRLVRCDHRLRSIFGRDQMFFPQIPESIGPHTSPIDPIHLPYTIRVDEDYHKDPTPTVYDIQVALEDPLRSKMLALTQNPQYTASMRQIATLDDQVALIVQALTHSRARHSFYTALSKDPATFVRRWINSQRRDLETILGEATRGGGEDASGPEFRRGGTDGVWDTTVAREAVRYMLAKPEAAMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWK3</accession>
    <name>A0A8G1QWK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_451781</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512824.1">
        <property type="nucleotide sequence ID" value="XM_025660670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWK3"/>
    <dbReference type="GeneID" id="37164072"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF1">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN RRT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH54902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="274" mass="31357" checksum="B5410CA970E936C0" modified="2022-01-19" version="1">MPHRHIDTTKAAWLYPLRGIYYFASHRYLWPLFKTRLIPIVLLSAFIYVLLFLFAYLPQVAFLSIFQGVGAWINGAFLVLGEGAAIVAALFEAFFVDETLVDIFDSVLVSEGHGELVTMSRVLYPQGDDVVKRLGKPTKSAVYAPFSLRQIVEFIVLLPLNFIPVAGTPMFLVLTGYRAGPFHHWRYFQLLDLSKQQRKERIRRRQLQYTTFGTVALILQLIPILSMFFLMSTAVGSALWTVDLENKRDLLGRRPGRDPEGLYRDDYNDDDAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWP3</accession>
    <name>A0A8G1QWP3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">beta-glucosidase</fullName>
            <ecNumber evidence="4 12">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_377674</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4 12"/>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512981.1">
        <property type="nucleotide sequence ID" value="XM_025656271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWP3"/>
    <dbReference type="GeneID" id="37159673"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001391">
        <property type="entry name" value="Beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF29">
        <property type="entry name" value="BETA-GLUCOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034242278" description="beta-glucosidase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="15">
        <location>
            <begin position="779"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="719"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH55059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="860" mass="93352" checksum="932BF76B4C851AE2" modified="2022-01-19" version="1">MRFTLIEAVALTAVSLASADELAYSPPYYPSPWANGQGDWAQAYQRAVDIVSQMTLAEKVNLTTGTGWELELCVGQTGGVPRLGVPGMCLQDSPLGVRDSDYNSAFPAGMNVAATWDKNLAYLRGKAMGQEFSDKGADIQLGPAAGPLGRSPDGGRNWEGFSPDPALSGVLFAETIKGIQDAGVVATAKHYIAYEQEHFRQAPEAQGYGFNISESGSANLDDKTMHELYLWPFADAIRAGAGAVMCSYNQINNSYGCQNSYTLNKLLKAELGFQGFVMSDWAAHHAGVSGALAGLDMSMPGDVDYDSGTSYWGTNLTVSVLNGTVPQWRVDDMAVRIMAAYYKVGRDRLWTPPNFSSWTRDEYGYKYYYVSEGPYEKVNHYVNVQRNHSELIRRIGADSTVLLKNDGALPLTGKERLVALIGEDAGSNPYGANGCSDRGCDNGTLAMGWGSGTANFPYLVTPEQAISNEVLKNKNGVFTATDNWAIDQIEALAKTASVSLVFVNADSGEGYINVDGNLGDRRNLTLWRNGDNVIKAAASNCNNTIVIIHSVGPVLVNEWYDNPNVTAILWGGLPGQESGNSLADVLYGRVNPGAKSPFTWGKTREAYQDYLVTEPNNGNGAPQEDFVEGVFIDYRGFDKRNETPIYEFGYGMSYTTFNYSNLEVQVLSAPAYEPASGETEAAPTFGEVGNASDYLYPDGLQKITKFIYPWLNSTDLEASSGDASYGQDSSDYLPEGATDGSAQPILPAGGGPGGNPRLYDELIRVSVTIKNTGKVAGDEVPQLYVSLGGPNEPKIVLRQFERITLQPSEETKWSTTLTRRDLANWNVEKQDWEITSYPKMVFVGSSSRKLPLRASLPTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXV3</accession>
    <name>A0A8G1QXV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ell binding protein Ebp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_376862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513484.1">
        <property type="nucleotide sequence ID" value="XM_025656239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXV3"/>
    <dbReference type="GeneID" id="37159641"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049403">
        <property type="entry name" value="Ebp1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21204">
        <property type="entry name" value="Ebp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ell binding protein Ebp1 C-terminal" evidence="2">
        <location>
            <begin position="539"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="775" mass="84029" checksum="88965BC450FED636" modified="2022-01-19" version="1">MSGDQPYRSADDEIKDPKFINEQTHNSGQSSIDQRLKRLREEILPFYPFLLTVPTDVPFRLGSRFVNNWAVGNDGPFTPEEQQLQYMTFLTHHEGDSLLVAVGDWSDATGNVMSDQRSGGQSAASTPSNNSVKKKITFNDYRNRRKSGASASPVGPEVSKQSTSVLDTPEASQRAARASLPSNDSQKPAGKPPVQSRAASNSGGIERKRPFVDGTSDSSRSQHKVAAPKKPRISPSPAKTERLKGNALPALLSPTLPPTSNSPRLPRLLSPTLPPDIEKELAGLGEGPLGLGSSQSDGASNNDLSSGSKIQKAKSAVHASSQPDSTHSSGLHSKQFYHGNDKRRPSSTDVSTLDNSLASKGNPKNHVGNTMSRSIGSPPVLQDASARAQLVVKLKYGRSNRKRIEALLKFSGKKKPAPPGSPVKSALDIEPSQTQKARQAAAKAPASEHPDHNKPQRLEGKGKHMGTITVSREHSKVPEKPQTPMSFSSNLTVNPSDRSKASSTTPVKDPKSSASRFDPYSGNDGKPSSHPAVKRPGNSATPTKLASPQSTNTASRQCDRRAWKDEYQKYSNLGRDLKHAAERHTAKDRVTTVDEKLAAATAIEAILCFIVAFVADDQSKALSRQTADSSSWLSILAYWRVVKKNSTPYPRLHSLCLILGAVSYDAIHALDLERLAATPLPGENTPAPTPGSDENPAASEDHKKSRKEFVELKNRPHECYRESQKLWLEGSRGLCEDVLSLGRTNTPLEVVRFSHAFLSEWCAKEGVGWNSRLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYQ2</accession>
    <name>A0A8G1QYQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_480110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512522.1">
        <property type="nucleotide sequence ID" value="XM_025662987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYQ2"/>
    <dbReference type="GeneID" id="37166389"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034808303" evidence="1">
        <location>
            <begin position="29"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="344" mass="37458" checksum="EADCA3901E640B04" modified="2022-01-19" version="1">MKAQLLPRIGSLGLVCLLCVLLAHQILQSLPDTGPSRIHARDLVVPVTPEVWPDNNLTARAVAGYLATRALDFETAVNKGNGLYCRCKAKWQLSDESPWTNINELEDYYTRRPYGKGAGKEPDSMASLGEALSAMGLPTVISSNNGKDGNLVPQIWSQSEDWETEIVAGGRTTRTDHEATQAFYINVMSPKSGLIIAENNESPVSISGRHCPVEKWSDIVWLNYAAMAKSTGSSVNKLKYVVRTHIVNRDTLNILQAVCGGPCPSWPGTPFDINQKKKGGVLINQNGLALLGTPNGGGAAWLLINHKQQLSRKMPVSVIAWTTSGLSANGTAEPWYHMMFQFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZN5</accession>
    <name>A0A8G1QZN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-patch domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_439681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514505.1">
        <property type="nucleotide sequence ID" value="XM_025658725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZN5"/>
    <dbReference type="GeneID" id="37162127"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="82"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="378" mass="43182" checksum="18B6FF9016C560F6" modified="2022-01-19" version="1">MAPPLPPHSESPARGRPDEDDEEEDYMSMIIEEPQQKETFAQKKKRQQREAEARAKVPSKAERAAQEAARRDAALSTSTLDPSNKGFQMMAKLGFKPGQVLGKPAASPQDSEKDTKDPEHRIRSEPLNLIFKEDRGGIGLDSERKRKFLEEAAEVTKKVKQEEGDYRDRVRLERETRRLEAQFHAAQKVAERLDAEAEGEVEIGPSSTETNGEEKEEQESHATPDVDGEESQTDTPASTTKKAKRPVKPTLQINILYRGLVRERQEKERAVQTRHMLQTSLPSSFFPNPRLPGYEDSTLDPEDHEALGGRREMSSILEQELEEEDPELEEFNALEPGERLGRLVQYLREKHHYCFWCKYRYETAEMQGCPGVTEEDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZS1</accession>
    <name>A0A8G1QZS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">mRNA splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_490147</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513526.1">
        <property type="nucleotide sequence ID" value="XM_025663645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZS1"/>
    <dbReference type="GeneID" id="37167047"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000649">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001164">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative (AFU_orthologue AFUA_2G06070)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000256">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13428">
        <property type="entry name" value="TPR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="10">
        <location>
            <begin position="13"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="10">
        <location>
            <begin position="167"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="648"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="523"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH55604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="979" mass="110164" checksum="C467BB7ABB1E76B3" modified="2022-01-19" version="1">MASGRKDFLSQTAPENYVAGLGRGATGFTTRSDLGPAREGPTPEQIQAALAKRAQLLGAAPPTAYGAGREKGGKDEKPDEEEDDERFQDPDNEVGLFAYGQFDQEDDEADRIYREVDEKMDKRRKMRRLVFRPFASPSAIFMKRFVHPLLHMRFVWTDYRRNSSTIHREAREQQEREDYERKNPKIQQQFADLKRSLASVSEDEWANLPEVGDLTGKNRRAKQNLRQRFYAVPDSVIASARDSTQFETTIAEDGTQTAANGAEAADGTITNFADISAARDKVLKVRLDQAAMGSSGDSASGSATNIDPKGYLTSLTQSELKAGEVEIGDIKRVRVLLESVTKTNPKHAPGWIALARLEELAGKIVTARNVIAKGCELCPKSEDAWLENIRLNEGHNAKVIAANAIKNNDRSTRLWIEAMRLETEPRAKKNVLRQAILHIPQSVTIWKEAVNLEDDPADARLLLAKAVEMIPLSVELWLALARLETPENAQKVLNAARKAVPTSHEVWVAAARLQEQMGTFEKVNVMKRAVQSLARENAMLKREEWIAEAEKCEEEGAILTCGAIIRETLGWGLDEDDDRKDIWMDDAKASIARGKYETARAIYAYALRVFVNRRSIWIAAAELERNHGSKEALWQVLEKAVEACPQSEELWLQLAKEKWQSGEIDDARRVLGRAFNQNPNNEDIWLAAVKLEADANQTSEARELLATARREAGTDRVWIKSVAFERQLGNIDEALDLVNQGLQIYPKADKLWMMKGQIYEAQNKYPQAREAYGTGTRACNKSIPLWLLASRLEEKAGAVVKARSVLDRARLAVPKSPELWTESVRVERRANNIAQAKVLMAKALQEVPTSGLLWSESIWYLEPRAQRKARSLEAIKKADNDPILFITVARIFWGERRLEKALTWFEKAIVSDSDMGDAWAWYYKFLLQHGTEEKRADVISKCISTEPKHGEVWQSVAKDPANALKSTEEILKMVADRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZW0</accession>
    <name>A0A8G1QZW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Fatty acid synthase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_398904</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514610.1">
        <property type="nucleotide sequence ID" value="XM_025657076.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37160478"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000006">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3330:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 16" id="KW-0520">NAD</keyword>
    <keyword evidence="5 16" id="KW-0521">NADP</keyword>
    <keyword evidence="6 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="18">
        <location>
            <begin position="1655"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="17">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" description="For malonyltransferase activity" evidence="17">
        <location>
            <position position="1799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH56688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2034" mass="226046" checksum="4FA60AEC4D122D42" modified="2022-01-19" version="1">MESPWSSLGSEESSSIFEAPWEEEFSSPLELSSSFLRFILDYTYDELSSASLDVAILREILSFVQTSLLRNENINTVLASKNDDPAVDRSILRTYFQACALANYRWTTGTSELLASAQTGQARLFALFNGQGVESYFDELVETHTIYEEHLASLMCLMSETLVRLAADDQFKEIFLHGLDVQAWLATPDTRPPIDYLTTPAVSLPLIAVCQLVQYAVACINLGVTPGEMRQYLYGASGHSQGVVVAAFLAAATTWDSFYTAARQVIEVLFWIGTRCQQTTSTMCPSSGLERSPSYMLSIKGIPQTALQRQIDQINAQLPAQQAVHLALVNGPQQFVVAGLQSSLQALERILQLGKNGSSSANTNSSRIPFRQRAPIISTRFLPIGAPFHSPYLQKTEDLLLQDLAPFTLRGADLAFPVYHTETAENLQSSENIIPQLIQMICTGRVEWEMLQQKVLPGFTHLLDFGPGGDAGIGSLVSQHREGTGLRTMIVSAHRGTNTNLSYAGDFYARYAAVRYSPTWFTEYAPSLIRSPSTDPQMLVDTKFTRVIGLPPVMVAGMTPTTTSPDFVAAILNAGYHAEIACGGFPDAGKMREGLKSLAAAITPGRGITCNVIYANPRAMAWQIPLLAELRRSGVPITGLTIGAGVPSPETVQSYIDELELEHLSLKPGSKGAIDAVLEIARLRPDFPVILQWTGGRGGGHHSYEDFHEPILDRYAQIRACPNVILVAGSGFGDGEGSYPYLSGTWSETLFGRPRMPFDAVLLGSRVMTAKEARTSLAVKQAICDIPGVGDADWEGTYKKPTGGILTVRSEMGEPIHKVATRGVKLWAELDRDIFSLPRGKQKDALLARKDYYIRRLNEDFQKVWFGRDVTGAVVDLQEMTYAEVWQRMVELLYLPHLQAWIDTSFRTLVWDWTRRMEERLGSGAAANEKITRAVLRDPSQLNHPHKFQEELFAKYPQAQKEVITAADADYVVLLSRRRGQKPVPYIVALDEDMEYWFKKDSLWQSERLEAVFGQDVGRICILHGPVAAQYTCTPNEPVRGILESLHNYYIEPILKERYTGDLSKVPLARKTEDLDSLPLVCDGFVLEQGVNAVTYRAMDIDRQPSCEQWLKALAQSTLAPWCRAIFTEPMIVQNGKRINNPLRRLFAATGRGRVVKVRNPQSTSMPEIFIREVEYQRTTGGKVQPHLIASAALRRASSEPTSDILMTLRDAASEPLELRFQYKPQLGAPSITEVRTNRNSRIQQYYQHIWVGKTPSLTTLLSPLDHIFRGEAVVLTREKIRQFAQSICNHNSKYTSETSQMPLYAPLDLAIAVGWRPLMSCLFHPLMSGDFLRLLHLKNSFEYCDGTEPLREGDCLSSEGRLTSIKIKQGTGKVVDAEGTLCRNNKPAIRIKSTFILLGEYQDYENTFAVEEERFSLNIYSQRDIALLKSRAWLTLNPGVDLLDYLHKDIEVEVRSRYSFLDSEKYADISVEGQVIYRSVTGDSQVLGTINLSGDNYVKNPVTDYLRRHGSQLDNDSQALPQPQTMLDDLEFTIPDYAAKYGQASGDCNPIHLSELFASYAGHENRVTHGMFTSGYVRGLVEAHVAQSDPSRMRSWSCSFDGKVSPGDKLGIKVDQVGLSRGNLLLSIQVHNMSSGVKVLSAQATVEQPPVAYVFTGQGSQQPGMGMELEKQSASARMVWQTADEYFSKTYGFSISQIVRDNPKTLTVYFGGVKGRAVRANYTSLKFDTVGDDGTVISKRVFPDITSSSRSYTFRSTNGLLHQTQFTQPALALMEMARFEDMRAKGVVKEDSLFAGHSLGEYVALAAMGRIFSIEEVSALVFYRGLTMQNAVKRDAEGVTDYSMCAANPMRVSPRFSEKDLHWCVAEIARSRGPGGLLEIVNYNVANMQYVCAGDLRALATLSELLDAIASGVLSLASVEEVQTFIQSTLARLEATATATKKRIVLQRGRATIPLNVNVPFHSSLLRPGVDSFRYLLHKHISEAMVNPDRLIGRYIPNLVAKPFELSREYIQGIMQLTKSPVLGDVLQKWPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZY7</accession>
    <name>A0A8G1QZY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_520781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514579.1">
        <property type="nucleotide sequence ID" value="XM_025665161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZY7"/>
    <dbReference type="GeneID" id="37168563"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="224"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="642" mass="73660" checksum="BB9457AD800A22D1" modified="2022-01-19" version="1">MARKAHSLLKHIPGASPKINRRKEKSKETLEPTYRQDSSNSGCIFVLEDPADFPRWKGIIERLLQVQYDLGDGNTSTYLRKDYNFLWEYVPRHFHHHFPHSRELFCLEAEELFRTLWVAVHEWAVDCTICGLVRRKVLSDPLDLVKAREQPMSRFLLKSKGGKRCQYCSLVYQCLQAYYPSFETHENTLVVGIYPNTGGFSLLIRDTQTTSWIESTLWAEAFPVQDAVEVCWRLGIKYLWVDALCIIQDDAIGVDWYEQSSEMDQIYSSAYVVIAADTAEDCSEGFLGTSQIQQLREVTVDWDGDTYICREKPNGQRDDPSFLLSRTPLSRRAWTLQETLLPSRVLHYTGTEIVLRLGDTFYCQCGECRFHHVGISQSDWHQIVSHYSFRQMTKPSDKLSALSGLAARMSDGDRKYLAGLWSDTLVTDLLWHSWASMDGGISYFTRFSYYDFLPALDIMQAECTCTSVNSFGPVSSGFIDLRGKLVPVEMVILDKPFTKHQGEYTGEWGRATRVHQGQTSLVRGWGTEIYEVLCDERMEKTDRMGEEERESWAQGKVDRQDLGGVVASNVYCLEVGTIIDRVLDVDGFTALGRSSRVWWLVLKKAERGDEFKRVGIGYKSSKDFKRDCDLFDSAEWSTVRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R061</accession>
    <name>A0A8G1R061_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3 15">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_375458</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP</text>
            <dbReference type="Rhea" id="RHEA:16341"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:16342"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3 15"/>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514019.1">
        <property type="nucleotide sequence ID" value="XM_025656170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R061"/>
    <dbReference type="GeneID" id="37159572"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000116">
        <property type="entry name" value="Phosphomevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000018">
        <property type="entry name" value="Phosphomevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="164"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR017288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH56097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="463" mass="50527" checksum="ACB658F148DE3496" modified="2022-01-19" version="1">MSYKAPTVTAVSAPGKVLLTGGYLVLDRDYTGTVFALDARIHVVVQQLRRSHRSDEQASEDVIVVRSPQFVDAVWEYGIQRCDNGGGVKVVQKNDGRANPFVETSLNYALTYISYVAASKDFGSLSITILADNDYYSETAFSKISSLQSPGRFVNFGVPLHEAHKTGLGSSAALVTAFVSALVIHRTLQPEDLGAAREKLHNLAQAAHCAAQGKVGSGFDVAAAIYGSCLYRRFSPSILESVGDVGSSGFEERLFAIVEDADPKHSWDTECLDFGMKLPRGMQMVLCDVECGSQTPSMVRKVLEWRKQNPEESLMLWQALQSNNDRLCLELKQLSQSPDAEAPNGFDDTRRLIERSRDLIRTMTQKAGVPIEPKVQTELLDAITSIEGVVGGVVPGAGGYDALAVLIEDKADVIQRLTQLFETWESKLEDDFGGKIGNVRLLGVRHGSAGVQNESLDQYAGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R097</accession>
    <name>A0A8G1R097_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_451700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513317.1">
        <property type="nucleotide sequence ID" value="XM_025660650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R097"/>
    <dbReference type="GeneID" id="37164052"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="244" mass="27310" checksum="CAF8115DDC6B60B0" modified="2022-01-19" version="1">MPDNKSTSSWPVKGRHPFSSFRFLFTSAGKMDKPCTTPTSLSEPLLPNTNNTTTITTHQPYYSPSQPQQQQQPDLFASEISKPLLHSPPLSEPDTPTENKTASFIWEDINPPAEYYLADKSTSPPPSPPPTYTYSQQDQQQQSPPQDKESDPTMIDTTTRSIPVSSLPGYNDVSGAVIVDYDGFPHFLSPQEEEERKMKLQRAVQEKMLGLPRQTSFEWERPLPAGSAAGWLPRYSPAKRGAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0N9</accession>
    <name>A0A8G1R0N9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GABA permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_399555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514289.1">
        <property type="nucleotide sequence ID" value="XM_025657100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0N9"/>
    <dbReference type="GeneID" id="37160502"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF8">
        <property type="entry name" value="PERMEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH56367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="489" mass="53075" checksum="4EED08510564BC6D" modified="2022-01-19" version="1">MYDSWSALSGVFIIGVDAGGPPVMLFGWVGVCVITFAVALSMAEWCSRWPVAGGQYSWVFLLAPPKISREMSYITGWFMLMGILAIGSANNSFAANFILGQANLVYPGYVIERWHTVLVTHAVAIWALLVNIFLPHLLNRLSRAILLWNVCSFIIIVVVLLATNKNKQDAAFVFQDFQNTTGFGSAMATMVGILPSFFGMCCYDTPSHMSEEMTHASRDAPKAMVMSVGMGAVTGFIFLLTLCFCIGDIDATANSSTGVPVLQIFYDSTRSKVAACFMTSMMTVIMMVGAVSLVAEGSRALFAFARDRGMPFSGILSRVEKRRKIPIYAILFTVVVQMAFNSIYFGTVTGFNTVVSIATTGFYVSYALVLLARLLGYFFGHDIAPVDGPYSFPLPVSLSLHGLGFLFLFFAFVTFNFPSDAPVTPDSMNYTSAAIGLIALLSIFTWFTTSRKQFKGPADVQGLVVDGVEQVGEVGERGASCSEKGKSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R145</accession>
    <name>A0A8G1R145_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_370946</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516058.1">
        <property type="nucleotide sequence ID" value="XM_025655981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R145"/>
    <dbReference type="GeneID" id="37159383"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17178">
        <property type="entry name" value="SECRETORY GRANULE PROTEOGLYCAN CORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17178:SF0">
        <property type="entry name" value="SERGLYCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="535"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="566"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="726"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="737"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH58136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="859" mass="90485" checksum="44C344FF6B1B95E7" modified="2022-01-19" version="1">MAPQAESAGSGPQPDGDVARKGSVKRAREMLQAGKRPERAPEEPAPSFRINPAHMTQWPLPDNAPLPPNLANPHATLVVPKGPPPVRPPRPDCPSPSVYSERSMSDVPPAPSPLNIKRPVPSFSQPFPIPPGPRPAIRIPIPRPPSPDSVAGSTPRVSVATDDLFRQSGISTVSSITELPSVPHPLPPQQRVAPGGAPKKTASLAPPVPAARQRASSVSPIPEELPDSPTISQDHYGSAQPYPPSWYSGQAESEILGTYLDGESDDDASRHSTHQAGVATATLLRQASVGTRGKPSLRTIQKSNASSPVPPSERTPVSARPTTSGTTGTEFILKEISIVPDRRDSVSSSSTGSAHFNLEKAPIVLDVSTQHPALARPYVDNGGLEKEIGALPRAAPTMSDKRPGGRRPPRLNMSAVRDAEARGSLTSLPDLIRRATRLASNLEHGRTASRNDLLNGGGGSRLQYDAKRKSGSIKSILASFPPPAATPEGGHSSWPFFFRRSTLHQIHSNEPPRADGDQEKAAPKQPRRCCGLPPWLFALICVVIIIVILAAILIPVGLLVVRHKSSGTSCATTNPCENGGVSVSSGSICSCVCANGYTGSRCTISGDASCVTTEVDDKNATMGSELPRLFEYAQQNYSIPLDAVTIMALFSQNNVSCTTENTLVSFSSVSTSSSKARRALSDSSLEEPSISSHLLAKVEHSPSSALSERTPTQALAARDSVATAHGIVFDDDPPSSTGTATATATATKTNHESSATQTSTSSSSTTTTNSSSSNSTTVTTEVLDFARVAVLYILEETGTLSAAEFSESNIQDYLSDNYSDAKSHKFTVDLTPSGVIGNYTLNFDDFEITLPSGSVVGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1I4</accession>
    <name>A0A8G1R1I4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyl hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_284708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515760.1">
        <property type="nucleotide sequence ID" value="XM_025655233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1I4"/>
    <dbReference type="GeneID" id="37158635"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18621">
        <property type="entry name" value="GH32_XdINV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.115.10.20:FF:000011">
        <property type="entry name" value="Glycosyl hydrolases family 32 superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="19"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="428"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH57838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="617" mass="69861" checksum="415F1A9B836BABF5" modified="2022-01-19" version="1">MERQISLSDEAQRWQPSYHFTAPHGWINDPCGLGHDPATGLYHLSFQWNPKGNDWGNMSWGHAVSNDLLHWDVYPEPCLQPTTEYDQCGVFTGCFRPNAVDGVPNALTVIYTSVKRLPIHYTLPYVPGSESVSLATSRDHGLTWQRLDCNPVIPRSPPDVKVTGWRDPFVGAWQFMQEQPEAFPSSDLCGLISGGIAGQTPTAFVYSINPHDLRQWKYMGPLVDVGLNLQPSRWSGDLGVNWEVVNWIPMTDDEDVTRLFILMGAEGGLLPDKSRKKTPRAQLWMSIKPCSSTQPRSTTDALASYAFSGVFDHGCAYAANSFWDPVTAQQIVYCWITEDDLPDDLRHQQGWSSMLSIPRVVKLITLRHVKQARRSELNAITSIEAQEESQETFTIRTLGVVPDPRLKALRSKTSSMHIEHLPLSTLDSCISPPKAHFSLTTSKWEIDTEFCVSDRCGRVGIEIRHGLVHQHKPADAEPPRRTILYWEPASETFYIQRPTPHDSRINHEPETAPHTLFMLETPSGEQKEETLQIHAFWDKSVLEVFVNERTVISTRIYLQPDQASQCELRFFAEGETNHDDPPAMLLQADSWDGLGLDKPDRVSLIEQLRMRNNSTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1J0</accession>
    <name>A0A8G1R1J0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">COP9 signalosome subunit 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_53293</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514471.1">
        <property type="nucleotide sequence ID" value="XM_025665458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1J0"/>
    <dbReference type="GeneID" id="37168860"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010387">
        <property type="term" value="P:COP9 signalosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033205">
        <property type="entry name" value="COP9_CSN8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339:SF0">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="6">
        <location>
            <begin position="48"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH56549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="217" mass="24808" checksum="A36AB49083DC23A7" modified="2022-01-19" version="1">MDLPPLTQEQLTAVVASAKSPTELYETLSNYESEACLLSMKKGNHTELLSLYYSTFFFSNLLVDKIPEARLSTQRVPQELLQNDSSLQNCLTLLRAVWQRKYDQVYKILRELPWPEALRPIVQSYESHFQEKTLKEVSRAYEAIRPAAAATYLGLDAAAAQQGDPAIMQKFIAYGWTWDQEKGLLHPKPIVDELPQEDVRLYNELSQVMALIGNRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2L5</accession>
    <name>A0A8G1R2L5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_304406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515433.1">
        <property type="nucleotide sequence ID" value="XM_025655361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2L5"/>
    <dbReference type="GeneID" id="37158763"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="81" mass="9444" checksum="90EE8B73B7003B77" modified="2022-01-19" version="1">MAPESINSVPCHSLRLSLSPDLFRRALRLKESWRWAWTTTYCSLPLGLVLRLFPSFLFPKFFTDFNLSICLCSRFGLTFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R356</accession>
    <name>A0A8G1R356_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_489063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514817.1">
        <property type="nucleotide sequence ID" value="XM_025663577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R356"/>
    <dbReference type="GeneID" id="37166979"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13808" checksum="EED0459AA0F9DBD6" modified="2022-01-19" version="1">MSNQYERQAEDLYEAENDPSPVSGTFRDNSYAHETRSGLKNQVPVTRDDDIYEDPMQPPYSNSDQQLAQDEDEAIDQSNVIQGRTRGAKPQTRNQYNEGPDEDDLPDEVLYGNVGTSSTRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4B1</accession>
    <name>A0A8G1R4B1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_448472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516333.1">
        <property type="nucleotide sequence ID" value="XM_025659938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4B1"/>
    <dbReference type="GeneID" id="37163340"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="267" mass="29693" checksum="EAB661DB10A9367A" modified="2022-01-19" version="1">MTSISTSTLPTITRSTFINSTFNELTPSDTITRSDLRDVTITCSGSAKTPTSLLRSALTSCIVKHSTTYRSKLNHTTLTNAIVSRTEATHTSFDTYSYSHRSTLSNAVLRDRASVKRSKVKDASLLGGSSLWRSNVSRCMIADECRVQRCKLVNCEVMCCVLVKTDLEGMVVRNGVWKDGVLVGRVREGEEVVVLKKGGEGVSILFLIFSSYCILVWRVWLIADMQKMQIPVNEKKLDSKDVKYWLEEESSDEEGVRAMSPPPAYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4B9</accession>
    <name>A0A8G1R4B9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_488229</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515417.1">
        <property type="nucleotide sequence ID" value="XM_025663512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4B9"/>
    <dbReference type="GeneID" id="37166914"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="11">
        <location>
            <begin position="333"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="267"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="378"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="448"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="481"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH57495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="548" mass="60741" checksum="3D7E230369F94AE7" modified="2022-01-19" version="1">MPKRPTTTPRRRDREQDRESTPPLPPYEPPTSTLTTLSHQPTTAPALSALLATHTSSTLRTHLQHAQEKLTDAAGEINERLTDAKERSKKAKERRMNLRSHTEENNIGEGGEEGNGSEEEEEEEGGDGIEEFEERVKATTKILEETIRGVIDKEVRGEEVGRVIAGLEGGVVERMRVRGVRRSQRGVQLRRRLRGDGSEEEEEEGGEEEGVDVDEDEEGAVPFLAQFEDELRGKMEEYNGLSLTRRYTTNNSYIGFYKIIHEAKHIGDEIPPPPHPSTWFSHLEDPHSQSQPHHHPSTTSTTTTSTSTRQTKTTTTTRSHPRPSPFPSASEDDEIAIQTERISLKCPLTLLPFRDPVSSTKCPHSFEREAIFTMISGSNQMVPDPRGSSGSGSGGGGGGGGRARKRVRSVKCPVCEVQLTEFDLRSDPVLVRRVKRAEMAELREREREMLGENQDHDGNDQGEVGGGGKRKRSGRRGSAVEVDDGDSGDDDDDDDGEERIRVKRERGMSVAAAAARIKQERAGSMVGVEEVDLDGEEEGEGYDSMYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4J1</accession>
    <name>A0A8G1R4J1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_519127</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517271.1">
        <property type="nucleotide sequence ID" value="XM_025665023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4J1"/>
    <dbReference type="GeneID" id="37168425"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF166">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="24"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH59349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="284" mass="32054" checksum="BC59927BBE2D28D3" modified="2022-01-19" version="1">MNITLVFGTLGNVAVTYMAGEVPSRADIKRSQMSSKVTYAGAIIYFTYIWCQKAVVLCFINRLLGVLPWPYIWIRVMWAILCVTYITLLLLFLTVCRPLGLYFQVYPDPGPCIRSTYHISAHAVFNCVTDLMLIILPIHWLLKIRRPWYKRAQLIGLFSIGIVLVVISALRFPFHQGSLDTSLQTILSPIEELLSAVVANVPTLYSLRRARQPETPPHPTQPPPKRLPRAVDSIIIMQTVDVEESRTDDQTLSTTITDRALSTTMADRDLNDDSDGHLVRNGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5C4</accession>
    <name>A0A8G1R5C4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_467529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517785.1">
        <property type="nucleotide sequence ID" value="XM_025662193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5C4"/>
    <dbReference type="GeneID" id="37165595"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="348" mass="38317" checksum="2E526169FEBD266C" modified="2022-01-19" version="1">MEPHNPTMNQTLAQPMNQTMNNNHQVQTPTHPQVQPQIQPQTHPQTHPQTHPQTHPQHHQTEILLHIDAANNQPICILSNNSQPTTTTIDPAIIITNPTSYIFAFRNPHSLYHAFANPTIYTLLTRHAHYIRLYLLHDLQIGYLPCSPHPLPFSSQNRDSLFFFDCATDPNMHYTTPPRLPCMPSSTHPVMLNNDCNNICAISWPGFDKLMGGWRVACRAIPRGHDVWYMVFNLASRGGWVPLGVGRSLQLLSTAVCVKERVKGRFRCVVDGCARGVVERFDGFLAANVASLGWAVVGDEEMVEVKVEEREGKEGSVKGVKGDGGGGGGGGGGVIVHAGFVLCDGGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5Y0</accession>
    <name>A0A8G1R5Y0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_487058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516242.1">
        <property type="nucleotide sequence ID" value="XM_025663430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5Y0"/>
    <dbReference type="GeneID" id="37166832"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000203">
        <property type="entry name" value="PH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058155">
        <property type="entry name" value="Skg3/CAF120-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25381">
        <property type="entry name" value="PH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="107"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="861"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="979"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1172" mass="129323" checksum="7CDB3DBD61A339B4" modified="2022-01-19" version="1">MGRSRVLSLMSVFGGSSRKDNLSQHHRTSSASLTLNNPPRRVDTPSSDTPSPLDASPISGTPHVERRVTSRPESTLFSHNPPLLEFSQDTPPELQPIFGYLNSHANKLYHEGYFLKLNDLDIHGRPCADRQWVECYAQLVGTALSLWDAAALDAAEGSEDVCPTFINLADASIKMLETLPTRNQGAQSLKNILSICSAGQNRYLLHFNSFHSLTQWTAAIRLALFEHTSLYEAYTGSIIAGKGKGLNSIKTILDRHRYKHEDWARVRFGAGTPWRRCWFVITPPNEKEFQKAQKSIKKKSAYDRAPRLITGDIKFYDTKKTKKARPIATITDAYAAYAIYPQSRALIEQSTLVKIEGKITVHSQTESTTDGFVFVMPEVHPAVSGFEMMLRFLVPTFDTFNLYGRPTRLIAATNHIKSIMFAFPNQRRYGYLDILDISSLMQTPGSQDWSEAEWRQQLKEATARRMAAAGSRTSSISASKPRFRSTMPNRQSNGRTMTHQRNCTSPVNRLDSNQSNDAVAPGAPSDVSISPIHHSRGSSDTAGFASIRRQAQAAEASPASSDQELVARGSERPGTSGVDDHRSTGSGRNQQLDPDDEPLGQHFRSTSPPSPVVLPPAFTHAPGEMPAMRPQPSPDLRKATNRMSDATLTQLLAASGSMNLLGASFPSGSHETIKESNQPSPLTPNTSSDQQGAPSLLSDTSEKRATLQEQGPPTPEDRPSNFGPPLTLPKRASLRLDTTKAVKRKPLPAHQIRESDAASVAGEPSYEDLRHTVDEEVLNWVGSRQFSLTSPDKESHQDEESIYDDASATSPDYASTRGSIYSKRSVRSVTRPRMGVMKTVGSGPPRQDLVIGDAHYTVDEPKLEPSADIPSIDFGPTLTYLPTTGRPSTGDTLKKSTHQRSDSNSTEKQFSYQAERQHSRSPSNNMMWQPGMTAPRPTTPGRLTAEQFVQQRSAPSPPIATHNRTLSSTPPPPRPASGDWTNNSRPQSHLSGNRDAPPRPRSRGANSIMNYNELSSHLSAREQEHVARMTGAPLLDISNVNKAQPTPVNPMGLVGAIDAREREKKTIREGLSNQMVQHAIVQRQQNWQQQQMASNASAAAYNPGSHYSLYNMPTASRTWDALNQPYRPDEPRRQSWYGQFASQQAQTPPIYQQNPPYGQHPGYSGNASTLHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R619</accession>
    <name>A0A8G1R619_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_220996</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518096.1">
        <property type="nucleotide sequence ID" value="XM_025654697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R619"/>
    <dbReference type="GeneID" id="37158099"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF113">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH60174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="411" mass="45468" checksum="9DC957B11D2D4655" modified="2022-01-19" version="1">MAKDDRSLEVKAVAAAFMSVACVTVILRCYVRGWIVRAFGWDDWAMVVAMGFYAMFSGCMIGGSLYGTGRRFKDLDAHQRVTAMEYWWFCEIAYCFAAVACKISVCIFLMRITVRRLHIWILWTVMVLTVVAGMVFMFIMLLQCKPLAYFWTRKAFNPDIHGHCMDIQIVIAMTYVYSGFAALCDFTVGILPIFLVRKLHMKHKTKMAVVGILSMACIASSATIIRIPWVHTFADWDFLYATVEIALWSNIECGLGITAGSLATLRPLLRKWLGSSADHNYDASPFPGPSGSRPLGKSGGMGRSHDRPYPLGSLDEAAVQNRLRPDKLAVTVTTIQSQVDPDTRLWRGGSSNSSEERLTGSSGNAERTHGTIPEGSDLELGMGLGIHRTFEVTQTSSGGTSQTTVGVREHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6B8</accession>
    <name>A0A8G1R6B8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_487225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516422.1">
        <property type="nucleotide sequence ID" value="XM_025663438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6B8"/>
    <dbReference type="GeneID" id="37166840"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="311" mass="36047" checksum="AA99D06E11932063" modified="2022-01-19" version="1">MQYPNMHVATAQSSAADLPVAPAPAVKTTIQPTKRIYPRSFFYQRGKYWTNEQVHALNCVSEKNVTPIDLLGKSFPTDEKILKSFAKLNEDFITPSKQEILDYHYKPHESPIRKNDILTIFLTLSWIHDLDKDCDYVPPTIDSTLSILGLRMDIFRANFIIDKYSIPYNLAKLNMKGVLLCDGGIFCPDDKWRQCPLVVLLDTYALSKRQARNNLFSCLLLPMAVKYEQGQKRDPYVSFCITANLSKYRVTRAEAPHTYFEDLRQGRRMEDKLVMKGTREYDLLKVEDRDEFLKVYWGICSFLVKSREEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6F4</accession>
    <name>A0A8G1R6F4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_457656</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517458.1">
        <property type="nucleotide sequence ID" value="XM_025661534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6F4"/>
    <dbReference type="GeneID" id="37164936"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF31">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14230)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="615"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH59536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="924" mass="102495" checksum="A00CB655AD63D64E" modified="2022-01-19" version="1">MPLESNETLDREDAPFLASGQRPSSPVEEESGPSDAEKEHLRKTRLRLMLTLFAMILAVEVGICMSNGPVTRIYESIACREYYAQYDPTQIGADGEVQEELCKVKAVQQDLAAVKGYMEFFDGILSAVLAIPYGLLADRRGRKSTICLSIPGFALNCIIQLVVMWRPDVFPLRTVWASSLAWLFGGGPVVAFAIIWTMMSDVSTEEERFGVASMGADFASSAASSWLMALDPWLPLLLGWGLAVVGMFFALSLPETMRVGSSQPTWKQPSMEMSQVSPGNAEYKEVPSKEQEHEVLSDEETLQGEEASFTTKAARPTFFASAKQRSRAYFAPYSFIFRNKQIMLLLTAFLVYRLSRGSSWFLVQYISTRYKWTLAEANFLMSFKPALTIPLFLFILPAISRQLLKTMKPTQKDLQLMRISIGLLAVGTLGIGLSPSVAMLIPSLLVQTSGSGFVFLTRALITTLVNREETARLFTIIEVLQSVGNVIASLSITTVFQIGLELGGAWIGLAWMMTATAFTLVGVAIWMFRIPSPGSPAACRADRTTFTPRLALQAYGSLLSKSGHVQSASPLIPLISSSPKIPLSWRDLPNFAIEVRTGVSPFFPTPRPSLSYPQWILRIFLFCVRLPFFIPVCIGYFLLFQWLPITSLGRKAALWCILGVPSIWWVDLQVDGVRKGTLNNDRHQNRLPGPGSIIASSFTSPIDALYLAAVFDPIFVSCYPSTREVEQLSVWQAILRAFALPQAKPQPKARTVDLKTIMRKYPGRPIALFPECTTTNGQGVLPLSPVLASAPHKTKIFPVALRYEPKDVVTPVPGSYITFLWSLLGRPTHYIKVRIGQAVVGVAADELPTHDATMFDPSASENGYPHDRDDERPFSETSVMVLEEQVPNYVGDSLARLGRARRVAVTAPQKLEFVKLWKKSYWTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6P9</accession>
    <name>A0A8G1R6P9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferulic acid decarboxylase 1</fullName>
            <ecNumber evidence="1">4.1.1.102</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenacrylate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">FDC1</name>
        <name evidence="5" type="ORF">BO85DRAFT_394918</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-4-coumarate + H(+) = 4-vinylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:33227"/>
            <dbReference type="ChEBI" id="CHEBI:1883"/>
            <dbReference type="ChEBI" id="CHEBI:12876"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-cinnamate + H(+) = styrene + CO2</text>
            <dbReference type="Rhea" id="RHEA:46920"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15669"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:27452"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-ferulate + H(+) = 2-methoxy-4-vinylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:33807"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29749"/>
            <dbReference type="ChEBI" id="CHEBI:42438"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>prenylated FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </cofactor>
        <text evidence="1">Binds 1 prenylated FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. May form higher order oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiD family. UbiD-like/FDC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.102" evidence="1"/>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6P9"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046281">
        <property type="term" value="P:cinnamic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033494">
        <property type="term" value="P:ferulate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1670.10">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01983">
        <property type="entry name" value="UbiD_FDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032903">
        <property type="entry name" value="FDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049381">
        <property type="entry name" value="UbiD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049383">
        <property type="entry name" value="UbiD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048304">
        <property type="entry name" value="UbiD_Rift_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00148">
        <property type="entry name" value="UbiD family decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="3-OCTAPRENYL-4-HYDROXYBENZOATE CARBOXY-LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108:SF17">
        <property type="entry name" value="FERULIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20696">
        <property type="entry name" value="UbiD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20695">
        <property type="entry name" value="UbiD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143968">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like N-terminal" evidence="3">
        <location>
            <begin position="39"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like Rift-related" evidence="2">
        <location>
            <begin position="145"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like C-terminal" evidence="4">
        <location>
            <begin position="355"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="197"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="221"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH59264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="535" mass="58556" checksum="54168E898B71BD9B" modified="2022-01-19" version="1">MLRIIRPSRRIFSLRPSRAFSTTPLRANDSPALNFRSLLSALRAQDDLIDITQTTSPDREIAALTRRVYETQSPAPLFHNVTDTDPETGLFKILGAPVGLRADPATRFGRLAIQIGLSPTATPLDILEKLIAAKHSTPLPPTPVPAASAPCKENILHGSQIDMTKWPIPRLHPLDGGNYLATYGFHILQSPDKAWTSWSISRAMHIENTPRTITAPIMPGQHIAQVHKMWADQGAKDTPWALVLGGPPAAAFVGGMPLPAFVSEDGYIGALCGEAMEVVKCETNDLYVPANAEIVLEGRISTTEKVGEGPMGEYHGYMFSDKAVPEPKIEVDCVTYRRDPVVPICVAGLAPDETHTVWGAAISAEILDALRQAELPVKMAWMPYEAQCCWVVVSVDVERLGRMGMKKEELSKRVGEVVFGTHAGWEAPKVFVVGDDVDVTDIGQFVWALATRYRPGADELVFEEANGLPMIPYMTRASRSEVPNPGKGGKSVVNLLLPSEFEGKRPWVPGSFEGLYSKELKQKVLGRWGELFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6U4</accession>
    <name>A0A8G1R6U4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_245526</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517499.1">
        <property type="nucleotide sequence ID" value="XM_025654882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6U4"/>
    <dbReference type="GeneID" id="37158284"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12347">
        <property type="entry name" value="RRM_PPIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034168">
        <property type="entry name" value="PPIE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="9"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH59577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="152" mass="16508" checksum="F06096589610AB27" modified="2022-01-19" version="1">MSEKARLKCTVYVGGLDQAVTMQTLAEAFVPFGEVVDITLPKPDLPNSNELHRGFGYVEFDLPEDAKEAIDNMDGSELYGRTIKVAAAKPQKDSNEGLGSKTAIWEQEGYLAKYAVDEEDKLAAEGGETDGAERQDPMQGLEELDVAGPKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R757</accession>
    <name>A0A8G1R757_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">5-oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_258801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516872.1">
        <property type="nucleotide sequence ID" value="XM_025655006.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37158408"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF26">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="11"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="244"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="743"/>
            <end position="1262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH58950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1299" mass="140719" checksum="BF93057E81007284" modified="2022-01-19" version="1">MPSVEPRPKLRISIDRGGTFTDCICKLPGQDDIVVKILSVDPKNYDDAPTEAIRRVLEIYYGTSIPRGTGLDTKDIESIRMGTTVVTNALLERKGERTALLITEGFKDLLEIGNQSRPFMFDLSIRRPETLYSEVFEVEERVTLRNCTDTDLRSMDLSSPLVLRELTGTSGETVQIIKLLNLESVEEYLRKIYADGYRSIAVCLMHAYTFPDHELQIRNLAQQIGFENVSLSHAVSQRTKIVPRGNSAVIDGYLTPTIERYLKQFLTSFPDIAKSDTKLEFMQSDGGLVPAHRLSGLHSILSGPAGGVVGYARTCYDEVSEAPLIGFDMGGTSTDVSRYDGTLDHIFETTMAGISMQTPQLNINTIAAGGGSILFWRDGLMSVGPESASSDPGPTCYRKGGPLTITDANLALGRLIPEYFPSVFGPNEDEPLDRDVVIAKFEALTVTINQDTGKSMSWAQVAQGFLDVANSAMCGPIRSLTEARGYDTTKHHLASFGGAGGQHACAIAELLGIQKVLIHKHSSILSAYGIGLADVVQEGQRPCAKAYDSSNLPSILADLEELAQATKDLLGNDGILNVDVDRFLNMRYDGSETTIMIAVDQTHDMLQSFVKAHHQQFGFTPTDRNVFVDSIRVRAIGRGSFAAPSPDVSASVPAKPSVPADKCPAAEATNKVYFDQLGWTDTPVYILKSIPLGQKVTGPALVVDETQTILVGPGSSATSAQDKLILDVKVSEKGRNVTTDTIDPIQLSVFRHRFMSVAEQMGRVLQQVSVSANIKERLDFSCAVFSPDGSLVTNAPHVPAMIGSMAFAVRGQIEEWKGRLKAGDVLLSNAPEYGGTHLPDLTVITPVFDAQGKDIIFWTASRGHHADIGGILPGSMPPSSKELAQEGALFKSFLLIRDGVLDEVGLARLLCDKPAQYPGSSGTRRYQDNVTDLKAQVAANHCGIRLIHQLIEEYSMEVVQVYMKAIQSSAELAIRNLFKRLAREFHQTELKEVDYMDDGTPICLKITLNEADGSAVFDFTGTGPQVYGNWNAPIAIAYSSIIFALRCIVDSDIPLNHGCLAPVTVHVPKPSLLNPAPTAAVCAGNVLTSQRIVDVIFKTLRVCAASQGCMNNFSFGTDDFGYYETIAGGSGAGPTWSGTNGVHTNMTNTRITDPESLERRYPVLLRRFCFRGGSGGEGRYRGGDGVVRDVEFRIPMMASILSERRVVKPYGMDGGEDGRCGRNLWVKGEDGEIMSTGGKNSVEMKAGDRLVIETPGGGGYGSKGGGEGKIEKDQAKVNRGFVPIANGSVEMARSLAEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7C9</accession>
    <name>A0A8G1R7C9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_457380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518479.1">
        <property type="nucleotide sequence ID" value="XM_025661513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7C9"/>
    <dbReference type="GeneID" id="37164915"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000292">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034810313" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="35"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH60557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="561" mass="61645" checksum="562709BAA0D9D0A0" modified="2022-01-19" version="1">MPKLAVALLALLAVGNAAPTKVARSAASPTAQVRNGTYVGVTNTHYQQDFFLGMPYAQQPLGDLRFTVPQSLNESWSGERDAKEYSDICIGYGTDSIWYPQSEACLTLNVIRDSSANENSKLPVGVWIHGGGFFEGSSADQRYNMSAIVANSYKIGKPFIAVSLNYRLSAWGFLSSSQVWGTGNTNLGIRDQRLALHWIKENIAAFGGDPEKITIWGESAGAMSVGYHLAAYGGRDDGLFRAGIMESGATITASPGNYTGYQALYDELAAQVGCSNVVDSLQCLREVPFEKLNAALNTTSGNSEFNFGPVIDGDIIREWGSLQLDKHEFVKVPILAGTNTDEGTAFGPTGINTTEEFYAYLTDGESGFQLPPTIAQEILQLYPDDPALGIPEFLGDSRVPSEGYQWRRTCAYAGDYVMHANRRRQCEAWTETSTPAYCYRFNMRAADVPILSGATHFEEVAFVFNNIAGLGYHYGKPFAGMPESYVQLSNLMTSMWASFIHDLDPNSGIKDSDVQWQPYGKDQPVDLVFDANVTSYSYMEPDTWRKEGIDYINSVANAYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7Q2</accession>
    <name>A0A8G1R7Q2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_448220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517187.1">
        <property type="nucleotide sequence ID" value="XM_025659884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7Q2"/>
    <dbReference type="GeneID" id="37163286"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH59265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="289" mass="32343" checksum="EBFD3CAE7FC23A13" modified="2022-01-19" version="1">MSAPFIPDFPSIGKNIYYYEPDLIDTPIPENANTHPSLIILCSWYGGATPRRVAKYTSGYRQRYPRTSILLINTSFRDYVARSLHSIDGNLTPAKNTITKTLQSTPDARILLHVFSNGGCNTVTQLARAMKSEPVNFKSALKLIIFDCCPGDSSFDRLYAAGAVALPTAQPGRAIGTAVLYSTAKVGYALQSMKAMRSIDDYRADLNDAEIFGEARRLYLYSRIDEMIPWKDVEGHMIEASRRGYSVTGVSFEDGKHCGLVMGDERRYWDAVERAWEGGKTIVWERSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7U2</accession>
    <name>A0A8G1R7U2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycine zipper 2TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_446285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519041.1">
        <property type="nucleotide sequence ID" value="XM_025659469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7U2"/>
    <dbReference type="GeneID" id="37162871"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008816">
        <property type="entry name" value="Gly_zipper_2TM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF9">
        <property type="entry name" value="CONSERVED HISTIDINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G11910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05433">
        <property type="entry name" value="Rick_17kDa_Anti"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycine zipper 2TM" evidence="2">
        <location>
            <begin position="171"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="278" mass="30893" checksum="7EC7808DAD93CF24" modified="2022-01-19" version="1">MADPYPQHQQQPYPSPVPNSETPYYSPPDGVYQHAGYDYEPQQFYNQHALPNQDPAYSSQYDVSQIPRSYPTQWNPQAASSNTNLSNVNNESNAAVPQYDPDRLAPGYEPPVRRGSNAEYYAQSAADMQAPPPPAPSAPETEQQPRAYDNDPTTAGGAAAAGEEEGERSLGGAVLGGATGYYLGHKKDHGLLGAVGGAILGNFVSNKMKKSDSDEEVEEVEVDDDRETEYTRYHSSHYRRLSSHGHGHHHHHHHHHHHGHGHGHRSRSRSRSQYEEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7Y4</accession>
    <name>A0A8G1R7Y4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GABA permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_456771</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519116.1">
        <property type="nucleotide sequence ID" value="XM_025661470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7Y4"/>
    <dbReference type="GeneID" id="37164872"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF3">
        <property type="entry name" value="POLYAMINE TRANSPORTER TPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="522" mass="56326" checksum="797FA6698AF1016B" modified="2022-01-19" version="1">MRQPSMDANADEALARMGYKSELPRNLSMMSILGLSFAIMAAPFGLSTTLYITLTDGQSVSVIWGWVVVTLISIAIAASLAEICAVYPTAGGVYYWSAMLSTRKWAPAMSFIDGWLTLVGNWTVTLSITFSGGQLILSAISLWNEDFVANTWQTILMFWAVIGCCALVNIFFSKWLDLINKVCIYWTAGSVVIILITLLTMADERRDAEFVFAHYDASQSGWPAGWAFFVGLLQAAYTLTGYGMVAAMCEEVQNPHREVPKAIVLSVVAAGITGLVYLIPIMFVLPPVQTLLAVASGQPIGLIFKTATGSAGGGFGLLFLVLGILVFAGIGALTAASRCTYAFARDGAIPGFRLWRKVNKKLDVPVWAIILSTVVDCLLGLIYFGSSAAFNSFTGVATICLSISYGLPIFICVLRGREAVKESSFSLGRFGYAINIVSICWICLAVVLFCMPTSLPVDASSMNYASVVFAGFAAISVLWYVVYARKHFTGPPIADEDMPGVMTGKPIDTENTYAAHEKEGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8H6</accession>
    <name>A0A8G1R8H6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO85DRAFT_446299</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519049.1">
        <property type="nucleotide sequence ID" value="XM_025659470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8H6"/>
    <dbReference type="GeneID" id="37162872"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="20">
        <location>
            <begin position="236"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="19">
        <location>
            <begin position="801"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="894"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="894"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RAH61127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="919" mass="101959" checksum="0D7A9D9A002E1F0D" modified="2022-01-19" version="1">MSGRILSHRLVPLLRTGLLARHVHNAAARTGGLLRSDGSAALRGRAWPVGANAIHNNVPAVRAISFHRILPKLAIKLVRLPAMLGGATVAGLAYFQYQATQAGNYAIDLFKRAGETAGDAASSLFTEIQGIAEQTQRGWQRTTDAVELPEWLQSIISPNEEPQSDNGGPGGKRPKESRLGAAAAGATTAGAFGYDESNEEDTRSERKIAEDDQMMLLTRKMIEIRNILQTVGQSNTLTLPSIVVIGSQSSGKSSVLEAIVGHEFLPKGTNMVTRRPIELTLVNTPNAQAEYGEFPALGLGKITDFSQIQRTLTDLNLAVPERDCVSDDPIQLSIYSPHVPDLSLIDLPGYIQVAGHDQPPELKQKISDLCDKYIQAPNVILAISAADVDLANSTALRASRRVDPRGERTIGVITKMDLVDPERGYNVLSDKKYPLRLGYVGVVSRIPQTTALFSRGSGNITGAIMKNEHAYFSAHPSEFGSQSDVSVGVSTLRTKLMHVLEQTMASSLAGTRDAISQELEEATYEFKVQYNDRPLSAESYLAESLDSFKHSFKAFAESFGRPQVREMLKNELDQRVMDILAQRYWNKPIDDLSAPLPELDPLSDLAKADPESLYWHRKLDASTSSLTKLGIGRLATTVVANAIQTHVDRLIANSTFATHPYAQKQIVDACNSILNDRFFSTSDQVENCIKPFKFEIEVEDPEWAKGRENVSKVLKEELRACETAFKRLEDSIGRRKLKDVMSFVDKVRKGEVFLEGDGAGGAGGFSSALLARGRESVFLRDRADLIKMRLLAVRSKQCSSKKNKYYCPEVFLDVVADKLTSTAVLFLNVELLSEFYYNFPRELDMRLGRHLSDAEVERFAREDPRIRNHLDVIRKKELLELALQKIESIRQLDGRERKNRNSDRPVGNREQRNRGWNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8P3</accession>
    <name>A0A8G1R8P3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FUN14-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_444972</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519461.1">
        <property type="nucleotide sequence ID" value="XM_025659154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8P3"/>
    <dbReference type="GeneID" id="37162556"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF0">
        <property type="entry name" value="RE45833P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH61539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="18741" checksum="29B43233E3575B6A" modified="2022-01-19" version="1">MAFLLSRTTTTLLGTGLGVGLSLSLHPLSPFRAAPMQCQYTAPYYRPESQISPDSGWAMDSQDPLLRKQGTTRNSSHTAGGGILTASNMRQVSLGSVLGLVVGVGLRAFSRVLVVLLGMGIVAVEWAAARGYNLLPVNTVQKYFKRVDLQKTVSHHIPFKVSFGATMGLAAFAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8S6</accession>
    <name>A0A8G1R8S6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spherulin 4-like cell surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_445095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519570.1">
        <property type="nucleotide sequence ID" value="XM_025659178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8S6"/>
    <dbReference type="GeneID" id="37162580"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF7">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034584691" description="Spherulin 4-like cell surface protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="35658" checksum="8A6A06A9A8B3E0FB" modified="2022-01-19" version="1">MFGSTSRLILGMLSCVALLPSQALAAHQHVGHRHHHPINPTQQPQPSTLITIAQGTAPTEAPSACYWAPSAVSSVIASASASAAAVVESNITAKVIIPFYVYPEAGAWTPMEELVAAFPNVHFTIIINPDSGPGSSSLPDSNFLTAVPRLTSYSNVLAIGYVPTEKGTRSISDVESDIKTYAGWPSASGNSSFAVHGIFLDEAPNAYSEELVSYYQQLANLIKESSGLGPENFVVTNPGTVPDSAYLTIPDSTVVFESPYDSFLSAVSEDSFSAIRGGNHSALATMVYSVPDTVHLPTLISQVGNISDQIFLGNTSSYTVYNSYMNQVIPLLLPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R982</accession>
    <name>A0A8G1R982_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_485188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519379.1">
        <property type="nucleotide sequence ID" value="XM_025663311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R982"/>
    <dbReference type="GeneID" id="37166713"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="270"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH61457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="399" mass="45567" checksum="FAA939633B4E0B67" modified="2022-01-19" version="1">MEVVYLTKQFRIDKFRDCPVELLFHLEQCLRLPVREALNLQDVPDFFETMRNHAKKDFECPSLSNPTRRINIYEFAARKYRKGFCDLEVPTCLFEPTCSDGVVDTIKKGDVQGLEKRLQEGLHPDGYSVAGIPLLCLAVVHMQVECVELLLRYTANPSARGYWFAAGPLDYVMPAPLSYSCRDHKAIIRMLVNAGSFFSYPNVLDSIFLYNDIDLLKRVMDEPPGLFAEWPHSGFEFIFHRLAWHGKGCDEIIDLIDSRAPEAARQIAPTGHTPLHYAVVNKNDVNMVKKLLRLPIYLSALDYNQNSALAMAVKENHVEAVKAMLGLPDINLLQLHEVWDFNITPLGQAMRQRNQTLMTMLLTHPRMCLTERARDAALVQAKELGLDDYLMEQISRLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9D6</accession>
    <name>A0A8G1R9D6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_107534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519469.1">
        <property type="nucleotide sequence ID" value="XM_025653833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9D6"/>
    <dbReference type="GeneID" id="37157235"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034651763" description="Cell wall protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="32579" checksum="A0CD90115C2E2F69" modified="2022-01-19" version="1">MYNFQSLPALLCLVLAVAPVLSAPVAAGDGAVVRRQSHHFNTNTQSGSNMGFSIPDGPSYNSGQYASNAYREDRGGDMDDNEGSSESSNTNAGNSMNIGIPGGPSVNLGNYFSNNYEESEEPRPKPSTTSTTTIPESTTAPPPPPVNPPIETSVPAPPAPPTTTTTTTQPPPPPPTTTAPPAPPTTTAPPAPPTITPPAAPPTTAPPAPPAPSTPSEPAPPVETEEPEEPVQACPAPEPEPQPEPEQQSPEPPAEHGPSPEPESSPAPEPTPAPQPNPTPSPQPEPQPDHEPASEPRIIPTPSPAAPALPAYTCQCPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9H7</accession>
    <name>A0A8G1R9H7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_483784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519680.1">
        <property type="nucleotide sequence ID" value="XM_025663184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9H7"/>
    <dbReference type="GeneID" id="37166586"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH61758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="53830" checksum="43A5A5EEC9C403D0" modified="2022-01-19" version="1">MSLPNLPHEILLLIIAELRYANKFGAIAKLCQTCKTVCALVQPELFRQGPQWLNWSDGTTVPPYKVEMVTLMRFIEAVVERPELGTFVRKLDMDILFFPRFDSLQNLPFGPRKVSMETLMRAYNHFPADWKQRHLTGNAGIHPLPLFMLLISLTPNLQELGLSHIETGLGGLELLWERDSQGIRRYDYLPNLKKLVIVLETMSHESLRNLIHLMHLPTLNEFSICGADEHDPGCPPFNLLQPESLSITMLDLGASTFTPPLLRQIVRACKRLKVFCISEAVIDRKCRHASRVKRSNILSILEAHKYSLLKLELNFNDCAPNPGGPDWSHYGSFTSFISLKVLQVEQSGLRDIPGLPNSLESLRIIECDRPVFMFLASLIAKSKSDRLSLKYVRISEKWEWRCKDQNWILGIEPTCELDKTAEGKAAMMEACRRLDNLIKKADFSVEIVDCAAWDRYVAEQKTTNEGVVVDNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAD7</accession>
    <name>A0A8G1RAD7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_445511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520009.1">
        <property type="nucleotide sequence ID" value="XM_025659279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAD7"/>
    <dbReference type="GeneID" id="37162681"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="45828" checksum="2C7335C0EBECBF40" modified="2022-01-19" version="1">MNHPATTALLTPNPMRSDHDQWGTTPQSPNNPSTTASKAAAVGIIKPSASLDKSTPIESLPFAGRGRQLSVPEQVCLVNLCAASMNDDDAHNHPKSFWIKISNKLELQTGRRYSWQSCRRRIQTYISKRKAHWEAYANGDPYPGVDIDTEVWDLLTSWLVKYNTPRDVTAKAPLGASVALPTRVEPQPPQIPEPVRMVPEQGLVQISTKIERVLVWLKSLPPLEDMEAMRTWTGYVDPLADWMSRSKVRRERRLVFQKTKNGEEQLEFGGDGLTDPALAYLPQPHQPSLALHDPLQGTKRPRELDDSFAERPAQRIRVDPGSHPSGSPYAEEHADNAHLKRKLVESYFESTFGKLIDRLSARFRAQGAKQQDAPGSCEAIMRDLFKDVGVAVAKALVRMDEPAVQDQLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAH8</accession>
    <name>A0A8G1RAH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF890 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_433620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520993.1">
        <property type="nucleotide sequence ID" value="XM_025658429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAH8"/>
    <dbReference type="GeneID" id="37161831"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000813">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="429" mass="49007" checksum="B6856D692631B04C" modified="2022-01-19" version="1">MRASRNIYKDEVDFTALALQSPEFAKYLKPNGQLDFSDPDAVRQLTKSLLQRDFELKVEIPENRLCPPVPNRLNYILWLQDLLDTTGDEYRDNYDPDREVIGLDIGTGCCSIYPLLGCSMRPHWRFVATDIDNDNIRTSRDTVFANKLDSRIEIIQTDPKDELIPLDTKLNVDRLDFTMCNPPFYASRDELIASAEAKERPPLTACTGAEVEMVTTGGEIAFIMRMIEESLHLRERVIWYTTMLGKLSSVSVLIETLLEHKNNNYAVTEFVQGNKTRRWAIAWSWTDLRPTVSIARGTAAIPKHLLPFPSEYIFTTQSESIDEVSGKIDTELSALHVQWLWRKNLATGVGFAMQNVWSRQARRKMQNPDAMAEMGEIDETKAALGFKVQVKKDAIDEKGVRVIVRWLKGRDSVLFESFCGMLKRKVEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAL3</accession>
    <name>A0A8G1RAL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PLU-1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_4657</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520571.1">
        <property type="nucleotide sequence ID" value="XM_025662081.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37165483"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15519">
        <property type="entry name" value="PHD1_Lid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15518">
        <property type="entry name" value="PHD_Ecm5p_Lid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000010">
        <property type="entry name" value="PHD transcription factor (Rum1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000014">
        <property type="entry name" value="PHD transcription factor (Rum1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000322">
        <property type="entry name" value="PHD transcription factor (Rum1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000035">
        <property type="entry name" value="PHD transcription factor Rum1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="13">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="12">
        <location>
            <begin position="163"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="458"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="461"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="14">
        <location>
            <begin position="600"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="1328"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="268"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="367"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1297"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1474"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1595"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1529"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1542"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1614"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1663"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1702"/>
            <end position="1724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH62649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1724" mass="193935" checksum="E797952834BA43BE" modified="2022-01-19" version="1">MVAPASAGGASTGLQPSTSRQPTRSASTHPSHSHNVPLSARRSEPLDLSTVERRGQPNAPREPSTRVRPHGLQEAPTFRPTEEEFKDPEAYIRKIAPEGKKYGICRIIPPENWQPTFAIDTERFHFKTRRQELNSVEGGMPPRSAKQAAGGAPQPSSDADSGTRANLNYLDQLAKFHKQHGTNLNRFPSVDKRPLDLYKLKKAVEVRGGFDQVCKMKKWAEIGRDLGYSGKIMSSLSTSLKNSYQRWLQPYEEYLRVAKPGVQQQLELEHGGPYTPSPNHSPMPKKPVSLDSATPSATPQPAPSNPVAPPSAAKEVEATPEKPTPPIEPARPIASGFTPVNAGSSGFTAVNRSPSFVAVNSGPAVKREADNGSLTPKSIAEHPANPSAASNGHAGPPMKRAISHESASHAENGEVDANGRRSKRLRKDAPLPTVSGSHMSLLRPAPPRQRKSDHRKTGDKCEICGKSEERSSILVCDSCDHGYHKSCLDPPLTTVPEYDWHCPKCLVGTGEFGFEEGGVYSLKQFQEKANNFKKTYFASKMPFDPVLNTHRRESEDDVEREFWRLVESLTETVEVEYGADIHSTTHGSGFPTIERNPLDPYSVDPWNLNVMPFHGDSLFRHIKSDISGMTVPWVYVGMCFSTFCWHNEDHYAYSANYQHFGATKTWYGIPGADAEAFEEAMRQAVPELFEGQPDLLFQLVTLMPPDQLRKAGVRVYALDQRAGQFVITFPQAYHAGFNHGFNFNEAVNFAPADWEPWGAMGVQRLQDFRRHPCFSHDELLLTAAARDQSITTAKWLAPALQRACARELSDRATFATRHRELAPHNCTLYSEDPAATGNCQLKFVVEEEDLPEDDYQCQYCKAYTYLAQFRCHKTGKTVCLPHVETYDCCGEPLTQRLTGPDHTLRYRIGDDALKALVLKVQERARIPEAWGEKLDKMLEDEPKPQLKVLHNLLNEGEKIPYHLPGLQDLAAFVQRCDKWVEEATNYITRKQQNRRKNEKAWRKGTSKAAQLEERDREVRRVENIYALLAEADKLSFDCPQMAALEEKTREIEKFRQDVNVALMNPNIRSVQEVEDLVESARNFNVDIPEVEGLEHILRQMKWNEEARRKRDRYLTLKECQEIIQAGEQLGLSETNDHLLHFKDLCRHGEAWEAKAKELMSVEAVHYQQLEALSAQASRFPVSPDTLAAVDAILTKQREAQRRIQSLYDRSRDPDFRNRPKYKEVRELMDSLEELNSRPTGAIDLEREQKRHEDWMRKGKKLFGKANAPLHILKSHMEYVEKRNSYCFDLEDRCRPPVEPASRDNTPDGLLESTSTPSMWGGGKSRKRDVFCICRHSEAGMMIECEVCHEWYHGKCLKIARGKVKEFDKYTCPICDWRQKIPRDAARPKLEDLLEWQAEIAGLPFQPDEEEILDNIINQATTFRDFLHSFTNAACTTTEEVPTLIFYLRKIEGAEVLLAYETNFFRQEIHKWAPVAPEPPPILEQSLSTRKPRPTKQQKIMAQLGVERPEDLPPHLRTKQPNFAKRKSIESQTGRPSILQTPGDGSNSDSGRSGPTLTPMADAPNPPYPFSANYSLPATESTPAFAPGSSAFLPHVSADSPSFPPRSPTLPHQGLDTSLFSSPRYTRDHNDAPPGVDVDSRDPFDSSPRQNLDDVFADLTNQDQDPDQEPEPELMENTHANEALEVLDVSNGDDSDGLPDADSPDHKVNGDTNGHAEADDHADEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAW9</accession>
    <name>A0A8G1RAW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_410142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520755.1">
        <property type="nucleotide sequence ID" value="XM_025657463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAW9"/>
    <dbReference type="GeneID" id="37160865"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05917">
        <property type="entry name" value="FACL_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF30">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="57"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="512"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH62833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="613" mass="67070" checksum="9EEA587AB0171EAF" modified="2022-01-19" version="1">MRVASVNCRGLFHRRCSVRKPLQLAALPGRRGLLTTSYSRGPTEPPLLDTVIGDHFAKIVNQYGDRPAVICKQQNDRATYSSLDARSNALARGLESVGVQTGDRVGVMLGNSMEHAVATYALFKLGAILVPLNPSFNATQVVSALAHLEASHLIISTESNLPRKDPRSNIPLLQHLIPDLSKTRIESELVPSLKNIISVDNSSGRVNTSDFNCLTAYKSLTSDATPDKSALPPRNLSPTDIVNIQFTSGTTAMPKAACLSHRSILNNGSQIGDRMRLTPEDIVCCPPPLFHCFGSVLGYMATATHGAAIAFPTEAFNAKAALRTVQEEKCTALYGVPTMFIEELSLLDEGEIPNEGFQYLRTGIAAGSSIPAELMKRLHKVLNLTELTICYGMTETSPVSAMTTTDDPIDKRINTVGRLLPHVEAKVVSLDDHNNILPINTRGELAVSGYLLMKEYWNDPVKTAEVMVADNDGKVWMHTGDEASMSPDGYLTITGRVKDLIIRGGENIHPLEIENCLLTYPGVIDASAVGVPDERYGEAVAVFIIHRELESEAANEDKIRQWVREKLSNHLVPKYVFFLQPSESFPKTASGKVQKFKLREDAVKMLKEKSNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB30</accession>
    <name>A0A8G1RB30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_444242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520830.1">
        <property type="nucleotide sequence ID" value="XM_025658969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB30"/>
    <dbReference type="GeneID" id="37162371"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="315" mass="34186" checksum="C15B182CA002B91C" modified="2022-01-19" version="1">MSDDEDFYDEYDEDIFWVEEPDPTVADDLAATATATNDLIFYDDPALEAEEFFSDWDDLSDDYYDQDPTAVRRQRALNALLAQKTLSAGIPPTKRSWKHPSKGLFDITAFQGVVWKSPADDLKIALHEPGEGEKVALLKNWREVFRNSNPAIGRARVRKDVAGRRGTGAPEVVDLYGAEDLEADEGEDADIEDGVEVDISSGNGNGTLEDVPAAGGDTDMVETGTKEGTQDLPDGIKPSDSLEVPKSKPNGVAAASADKPATRGRKRKAEEESEPVPEATSKTRSKRVATQKVGEAKAPNPAPSGPVRRSARNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBA1</accession>
    <name>A0A8G1RBA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_14826</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520935.1">
        <property type="nucleotide sequence ID" value="XM_025654125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBA1"/>
    <dbReference type="GeneID" id="37157527"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000343">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="61"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH63013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="308" mass="34530" checksum="BCC545E6469C5E89" modified="2022-01-19" version="1">MLTCCCSDEPRFARDRSASPRDEPRADRTRSRSPNGRVDDRAPIDPRKNLDDEEGAINTGSNLFVTGIHPRLTESDISRLFEKYGDVENCSIMVDPHTKESRGFGFVKMVTAEQADAAKEGLQGEVIEGRTLSIEKARRSRPRTPTPGKYFGPPKRDFRGGHRGGRGDRYDDRRGPYGGSWRRGDDYRYGRYDSYSDRRDYGGRDYRDYGGRRDYRDDYGYRGGGSSGGIDRYASGGREDRYSRDDRRDDRREERRGGSGGGYYDRDANPPSYGSAAPARDAYAGGGGSSAGGGGRSYDPRDDRYSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBE5</accession>
    <name>A0A8G1RBE5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_17839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521010.1">
        <property type="nucleotide sequence ID" value="XM_025654335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBE5"/>
    <dbReference type="GeneID" id="37157737"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="2">
        <location>
            <begin position="27"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="340" mass="37984" checksum="0226C199C04DA443" modified="2022-01-19" version="1">MSVSSTKDPLDGISGELASSGGAFKATLLFFMAIACYNVAELVVMVLSTFRRWKGLYFWSLLLSGCAGVLPYTLGFIMKFFTQAPSNLSVTILSIGWWVMVTGQAVVLYSRLHLVICDERILQRVLYMIIANVFLLHVPTTVLTYGSNAVGDEQPAWVIGYNIMEKVQMTGFTIQEIVLSGLYMWETLLMLRICLVRENQKIMYQLIWINVAMLVMDLVLLGLEYASFYAVQITLKGAIYSIKLKLEFAVLGRLVAVVQNRRPISIDRDINLYSLDRETTSAPDRSLASAGESVSSRTPFCVPGTGYANGTHRNINLDTGKLVTMRELSAWVQRPNDDHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBK1</accession>
    <name>A0A8G1RBK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_444016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520594.1">
        <property type="nucleotide sequence ID" value="XM_025658924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBK1"/>
    <dbReference type="GeneID" id="37162326"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="64" mass="6857" checksum="9B69EE7B9DF09777" modified="2022-01-19" version="1">MGACTGVLTFSFFPPPLHRCGGGGGDWGPDQNSSLREGRIIGNNRTPLALFGRCYPRMVHGPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCD8</accession>
    <name>A0A8G1RCD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_465176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521195.1">
        <property type="nucleotide sequence ID" value="XM_025662040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCD8"/>
    <dbReference type="GeneID" id="37165442"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="225" mass="25711" checksum="506CBD8D1743EE1E" modified="2022-01-19" version="1">MLESNDHQVRRHAIKTVARAICERRENRYQHKDLDNLHIEILPMPLSADGGPLFEPEFFWPYDKSLPDPDEEIAHILSDYFGEYISCATLFHKFDWQHNPRQPSDFPCSLCELDIDNPIEWCVGGITGIPGGPRMKCFLLESVNADDEQITRGEILCMCRIMITCLRSRKYSANKVSPVLLISFVGPRHARILLGHHDGSNLNIPELKILLRWWCSSAVGDTING</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD85</accession>
    <name>A0A8G1RD85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_444792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521464.1">
        <property type="nucleotide sequence ID" value="XM_025659110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD85"/>
    <dbReference type="GeneID" id="37162512"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019268">
        <property type="entry name" value="DUF2278"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10042">
        <property type="entry name" value="DUF2278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="244" mass="27553" checksum="22958F1343F68B94" modified="2022-01-19" version="1">MPVPHYGVWACRPFDYYAEGRGQPTPHIYLYFRDDSSGKRTAAINVKSSGKESRLVYWVDKDFTHPMTDKLDTLELGFHLIQDPNNSHNNGTQHRHHDHRHFRYNHYTPQHTDLEGLDFYRTKGLVNILAGEILKHDIDGPDNDILDKLEPIIQAAINDETATAYIFGASFGSGIHNIHMNQGSLPKYDNGIYSDGGLLFKFSDGHWEAVFLAFASQRLPTGDDGEAERGSESLLQIIREAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RE00</accession>
    <name>A0A8G1RE00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_455700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519462.1">
        <property type="nucleotide sequence ID" value="XM_025661404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RE00"/>
    <dbReference type="GeneID" id="37164806"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="244"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="500"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH61540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="571" mass="63255" checksum="01621C8E9F856B1E" modified="2022-01-19" version="1">MRAKHPESDDQFPISTPKRQRTTATNGTVNGHTNGERERTPEATTTPTKRVKSTPQKPTTDNTPAALKASGLKTPTQKAKAKNLFSTPTKKPTVATPSKARADRSAKKKSARLLLEQDDEDIWDGADRLAEEILQDDTNEAPSKASTTGQGVLESIEEESSQPATNGATEGAPTPKRRAGRPKGAKNKRSPTPEGELPAHERYFFQNRAGPPRTSNNNLGKVNLLTHEEYFERMSQYADPYKQEKSFLLDLHCRSFPQWDFEFDQGFNICLYGYGSKRRLLQEFADWLYRRHHSSSASSSVVIVNGHTPNMSIRSIFATIVTAVLGADIPSKMGSQPQEVLELLQSVLKSRSSQKPITVLINSIDAPALRRAANQALLARLAATPKIHLLATADTPNLLLMWDLSLRDQFNFVFHDCTTFAPFDTEFDVVEEVSTLLGRKGRRVGGKEGVEFVLKSLPENARNLYRLLLTELLSMADEGHMSDDDMDGGGNGGGDGSNGRGEETGIEFRMLYQKAAEEFIASSEMMFRTLLKEFHDHQMITSRMDTSGMEILGVPLARDEMEGVLEDLVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RE22</accession>
    <name>A0A8G1RE22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_14067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520891.1">
        <property type="nucleotide sequence ID" value="XM_025654072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RE22"/>
    <dbReference type="GeneID" id="37157474"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="148" mass="16550" checksum="7E63FA16D6A61DBE" modified="2022-01-19" version="1">MVTTHFFSYPEVARGGSIVDVKLPKIRAPLKVLVGTSAPKRRYSLLRPGGSGVKHPKGNYVTRHSPAREAVRQVTILGFHDHFCPRRFCCLVSQTISSKHHHHLPYDSVLPSSHHGSGYRMQTVTPPRVSWSHFSPCSINTLEATLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1REG3</accession>
    <name>A0A8G1REG3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_410290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520832.1">
        <property type="nucleotide sequence ID" value="XM_025657473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1REG3"/>
    <dbReference type="GeneID" id="37160875"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000004">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000007">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="7">
        <location>
            <begin position="74"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="8">
        <location>
            <begin position="327"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH62910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="577" mass="61606" checksum="C22B84BC9EB62BE7" modified="2022-01-19" version="1">MRAPSPLLRSLRSKQPALPSRCLPVRQPSTRTPFLAFSRSVASYTHPHHASAISALPTAVDTSSSDFKENAQQMQELLDRMASLHSTISQGGPQKAKDKHIARGKMLPRDRVTALIDPGTSFLELSPLAGHEVYSDDVPAGGIITGIGTVEGVTCMIVANDSTVKGGTYYPITVKKHLRAQAIAQENKLPCLYLVDSGGANLPHQADVFPDKEHFGRIFFNQARMSSLGIPQISVVMGPCTAGGAYVPAMSDETIIVENQGTIFLAGPPLVKAATGEEVSAEDLGGGQLHSTISGVTDYLAVDDAHAIVLARRSISNLNYPKTTIPLKDIPSDAIREPLYDPTELNGIVGTNLRRQIPVHEVIARIVDGSEFAEFKRDYGTTLVTGFARIFGHQVGIVANNGILFSESSLKGAHFIELCAQRKIPLVFLQNISGFMVGADAEKGGIAKNGAKLVTAVACADVPKFTVVFGSSAGAGNYGMCGRAYSPRLLFMWPNAKIGVMGSEQLSAVMEAVGRTADPDLKARIDRESEAVFSSARLWDDGVIPPAQTRRFLGLGLAAAVGGKVDDVQTRFGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RER5</accession>
    <name>A0A8G1RER5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_433859</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521251.1">
        <property type="nucleotide sequence ID" value="XM_025658437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RER5"/>
    <dbReference type="GeneID" id="37161839"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006576">
        <property type="term" value="P:biogenic amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000013">
        <property type="entry name" value="Glutamine synthetase bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000005">
        <property type="entry name" value="Probable glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="8">
        <location>
            <begin position="20"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="9">
        <location>
            <begin position="124"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH63329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="488" mass="53945" checksum="7C0794C9CFB7CA4E" modified="2022-01-19" version="1">MSSTTPPYQVTLENIAHVLQNDTRVKLAGVDVDGMLRGKLVSKKKFLSIVADGFGFCSVIFGWDMHDRTYFKELTISNKENGYRDLVAVPDLSSFRRIPWENNVPFFLVSFLDPDTNKPVCACPRGLLKSALGKAEAAGYRAMAGAEYEFYQFRAPGAHSNPERNASATATFLKENPVESLPPLTEGMFGYSLTRPIHNQDYYYGVFDACEQFNCEIEGWHTESGPGVYEAALQFGEAKEMADKAGLFKYVVKSIGTKHGITPTFMAKPREGLPGNSGHMHISLVSSDGKNAFIRDTPDPNPPYPDVAYLSDLGRHFLAGVLTGLPDIMPMFAPTVNSYKRLVENFWAPVTVSWGLEHRAASIRLITPPTASAKATRLEVRVPGADANPHFVLAAVVALGWRGVEKKLEIPVPPLSKGEDMGGASDKGVRLAKSLREATTAFMRKDSVAREVFGDAFVEHFGGTREHEVRLWEEAVTDWEVRRYIETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VG63</accession>
    <name>A0A8G1VG63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_443660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509828.1">
        <property type="nucleotide sequence ID" value="XM_025658885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VG63"/>
    <dbReference type="GeneID" id="37162287"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH51906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="351" mass="38795" checksum="7CF9F67C2DA0AB16" modified="2022-01-19" version="1">MPAIDNAEVERRIADALQEAKNVYRRLPEAQNDAARLEAISKLKITKFDKQVATVLDVVRPLEWKLENGQPVERPIKDREAVTAALLYRRGEEVERCDRCQTLGPFAKCIISPSLGGRALHRAACANCIFYHQGTYCPHRLKFEKSKGEMWAESDTQLVLPNGGLRQTLALTGETGFGFLRVNDEDSTSKAQELGESSAPNNSSPAHQSEEFVPSGITPSSEEQDNLPTSPNNSNDSNDNEDEARVDPSAMAEGSTLADDMVTMPQSSATQLGQYLWPYPPADTLAGGLSYQFFSSQDMPEDDSYILPQLSATQAEEELCPYPPAGDCFLAQVPEHAEYSIEHEPQENRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGI6</accession>
    <name>A0A8G1VGI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_507791</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510233.1">
        <property type="nucleotide sequence ID" value="XM_025664419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGI6"/>
    <dbReference type="GeneID" id="37167821"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="275"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="518" mass="58275" checksum="044584063FDE7913" modified="2022-01-19" version="1">MCCWTRLRSSLTPYYRAWQIQCDGEFPQCNWCKHHNLACTFNRFRANSDTGHRVIVVAPDTPKAVIPNIADGPQDLLARPSSQVADSTRSSRIGNTFLNNVTYLRGHHVFSNEGQRWIESQVGESVNFDKLFSMELRWLKPLRSYTVPGADAPAGPQLPSRVNVEKYVQIYGSSSQGLVFPVISQPVFGKTLDLAYSHLQLPGSNSAKSCVYAFLALISLFGMDDNIHGAMDCQSYASVAQSFQIPVIEEMTVDGLQTLIMLVQVQYFLGDLQSAAATLSIATRLLYTLEAHTLPANKPSAPYDKGDMRCHLRDLFWLCYSFDKDICLRTGQPPCINDAHCDLTMPPDYVRLHDLNLQQSLPQVDEHLVPLFPWDLRLSMLKSKVYEDLYTAHALQQSVTELLSSIRGLDEALEQWRLSLPIEFRPTLYFSRETPVSANLNTMAVILRLGYYHCLTVIHQASTRCQILEADLAGPRLDGIASSTKLTITASRSTLLYLHKVLPVVNPECSWYGFTDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHM5</accession>
    <name>A0A8G1VHM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_504353</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511476.1">
        <property type="nucleotide sequence ID" value="XM_025664297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHM5"/>
    <dbReference type="GeneID" id="37167699"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH53554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="218" mass="23562" checksum="4DFCCE96080AB177" modified="2022-01-19" version="1">MAVTDLTPQAPKKEGDTYTKALTLNHLWAAKTTLQNPSLFPTLARAQHPQILWIGCSDSRCPETTFLDLNPGDVFVHRNIANVVNSQDVNCAAVVEYAVCHLRVKHVVVCGHTCCGGVGAVLAAPKGDGNGDGDGEKSVLDAWLRPVKRVRDRHASELGGIHGEYERGVRLVELNVLEGVRVLKGMGVVREAVERGEVQVHGVVYDVGCGVVRELEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHM7</accession>
    <name>A0A8G1VHM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homoserine acetyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_454091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825085">
        <property type="protein sequence ID" value="RAH52387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510309.1">
        <property type="nucleotide sequence ID" value="XM_025661199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHM7"/>
    <dbReference type="GeneID" id="37164601"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005757">
        <property type="entry name" value="PRK07581.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF15">
        <property type="entry name" value="HOMOSERINE ACETYLTRANSFERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="54"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH52387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="353" mass="39696" checksum="7C99D787D7D44234" modified="2022-01-19" version="1">MSQEEYDTFKLGDWELQNGEKLLDAHLAYKTFGDPASPAIVYPSWFSGLLSDNYWLIGEDKTLNPKKYFIIVPALFGNGQSTSPSNYAHPVPFPKCSFYDNVRAQHQLVTQHLKITHVRAVIGWSMGAAQTYQWATQYPDFMDLAVPFCGSARTSLHNKVFLEGVKSALLAAKHTPSAGSGNGGLLQAEQTLRTWSDTEKEVGLKAFGRGYAGWGFSQAFYREKLYETALGFKDLEDFMQNFWETWALSKDPGNLLTMLQTWQNGDVSKQEPYNGNFEKALGAIKAKTLVLPSKTDLYFPPEDSEYEVAFMQRGTGTLKVFPSIWGHWAGGPGQSKEDVKWLDEQLAEFFDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJK3</accession>
    <name>A0A8G1VJK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation elongation factor eEF-1B gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_452228</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512707.1">
        <property type="nucleotide sequence ID" value="XM_025660770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJK3"/>
    <dbReference type="GeneID" id="37164172"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000148">
        <property type="entry name" value="Elongation factor 1B gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF10">
        <property type="entry name" value="ELONGATION FACTOR EEF-1B GAMMA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="89"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH54785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="219" mass="24096" checksum="90C43E9F54DAF721" modified="2022-01-19" version="1">MSFGTIYTYPNNPRVMKTQAAANFNNLTLTLADFKMGETNRDPAFLSKFPMGKVPAFEGADGTLLAESDAITQFVAESGPAAGQLVGSTPAERALIRQWICFADGEVLSGVTSLALWRIGYKAYDEATEKSGLEKLTRALGALENRLKGRTWVATEKLSLADISLAAALYWGFSLSIDAEMRKEYPGVVAWYERVLESEHVKEAFGPKVFVEKRKEPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK86</accession>
    <name>A0A8G1VK86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bis-tetraphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_450502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514401.1">
        <property type="nucleotide sequence ID" value="XM_025660388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK86"/>
    <dbReference type="GeneID" id="37163790"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF3">
        <property type="entry name" value="5',5'''-P-1,P-4-TETRAPHOSPHATE PHOSPHORYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="2">
        <location>
            <begin position="207"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH56479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="345" mass="37084" checksum="3FCD16B5561F49A7" modified="2022-01-19" version="1">MQLGLSENLSSLVSRRFVAARDAGHLIFSSTHLATVHTSSIPYQVRYCPALAKKPTGAPKPDKAPSGPKPDPFQDPSPDLLLAQIPRENPSHVLVLNKFPVIPNHFILATKAWQAQTDLLDKEDLEAAYACIKAWAEGSQPEGQGSKKLFAFFNSGDESGASQPHRHLQFLPVEAMAQGDSENWQPLIDAVARQPTSSGTGYQHLSQVPFAHFARPLPPNPSSETLHQIYLSLYRAAVATAKGGLSDAGQVTGPAAISYNLAMTETTMLICPRRSESARVMVDSTAAVDVAEAGVVALNGTVLAGTLMVKAEAEWDELRRNPTSLHNVLAAIGYPQPDAREVSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK90</accession>
    <name>A0A8G1VK90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_470871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512979.1">
        <property type="nucleotide sequence ID" value="XM_025662432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK90"/>
    <dbReference type="GeneID" id="37165834"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="389" mass="43629" checksum="82E62E839A3E0443" modified="2022-01-19" version="1">MPPPTPTPQTLTLFLRAQTTLYGPSITTTPSPSTWTPPPSSGGHLGRYLWTDAIGVLNFLTLHRIHPNPPSENHYLTLASQLITSVHNTLGRTRDPPHTPLPGASPSHPLAGGLRIGKPSATGHDCDGQYHHYLTLWMFALNRMSVASGEGKWNKLAVELGRAIHPHFFIRGVDGRRLDRMVWKLDTELRRVLVGSEGNLDPVDGFVVFRVVRAYELAYGGAGDGGVLEEEIEDYRRVMRRKGRQRVSDDLLDLGMGLWTAHLVEGEEEEWAGELLGREVERVYDLFEIKRYLQRDPRYRLAFREFGAAMGIKCVAEQLAEKDTAVDLKVYADQIVDFWAPYMAGEEEDDIEDLRPITQVMYAAALIPGAFCRGFFDNEPVVPPVLNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKI0</accession>
    <name>A0A8G1VKI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_375951</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513637.1">
        <property type="nucleotide sequence ID" value="XM_025656200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKI0"/>
    <dbReference type="GeneID" id="37159602"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="60"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH55715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="409" mass="46838" checksum="45F4891D92BE204F" modified="2022-01-19" version="1">MTLFRHTINKPLRSLSYNSSKSLSFKTITPTYPIEEERNPHYNINKYYPARIGETIGNKYCLISKLGWGAYSIAWLAKDISRWPWQSTKYVTLKITNCGEGEKKAAEDELRISQHISALRSEHEGRSYVRLVEDSFEVRGILGDHLCLVFEPLREPLWLLGRRLGSTNGVPPQVLKAFLRVILTDLKADNFLIGFEDITIIDKYVRQQEAHPAPHVLRNGRPIYESRNDFGPPKKGVGMLKISDFSAAVFGDVLTPHNHDIQPQPFCAPEVLLKAGWSYSADIWNLGTVLWELLADETLFDGLCEHRRKYSKEVHVAQMIRLLGGPPPSRFLDNCDPCIRDGLFSAQGTFKFPGLIPSEEFNFSNMTPFLDGEDKRLFIGFVRRMLQWEPESRASAKELYNDPWLCYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKM4</accession>
    <name>A0A8G1VKM4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase 39 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_451094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513772.1">
        <property type="nucleotide sequence ID" value="XM_025660514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKM4"/>
    <dbReference type="GeneID" id="37163916"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000358">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 39 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="59"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="382" mass="43805" checksum="F561C6EB0E682DE8" modified="2022-01-19" version="1">MQTSRAVNSAMGARAFVPAPKIRFQIQRRNLQDVAITRTGKPILKVQGGRSSLGGHTATVFGATGFLGRYIVNKLATQGCTVVVPYREEMTKRHLKVTGDLGRVNFIEYDLRNTQSIEEAVRHSDVVYNLVGRQYPTKNFSYTDVHVDGTERIVEAVAKYDVDRFIHVSSYNASRDSPSEYFATKAWGEEIVRNIYPETTIVRPAPMFGFEDNLLHKLARVTNLLTSNHMQERYWPVHAIDVGTALERMLHDDSTVGQTFELYGPKNYSTAEIAELVDREIVKHRRHVNVPKAILKPLAYYLNKYLWWPTISADEVEREFIDQVIDPNAKTFKDLDIEPVDLSTLTFHYLLGYRSASYYDLPPATERERQEEKKYLHVLDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKQ2</accession>
    <name>A0A8G1VKQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Vacuolar protein sorting-associated protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_450169</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the retromer complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the VPS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514703.1">
        <property type="nucleotide sequence ID" value="XM_025660313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKQ2"/>
    <dbReference type="GeneID" id="37163715"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07625">
        <property type="entry name" value="BAR_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06891">
        <property type="entry name" value="PX_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000046">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000034">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014461">
        <property type="entry name" value="Retromer_complex_Vps17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037907">
        <property type="entry name" value="Vps17_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011791">
        <property type="entry name" value="Vps17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="123"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH56781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="588" mass="64888" checksum="32F971A2180C9AA1" modified="2022-01-19" version="1">MDYSAISHDPDHPAGTSPWASPRPTQTTFPASVTSDIPPAPLPPQDPYNAESQPTETPGFQENEIGSPDLSARLQGAHLGEPGYADEQSQQTPQQHGQQPRSQLPARYQTGPRQNPRQPAPVYRIQAKVTGLERTGKKDPILRFDVHTNIPKFRTTQYRDVRRTHAEFVKLADHLISANPEALVPAVPPPLTPAGAGTEEDEHRVKSSMQRWLNVVLSNEVLTHDDEVVLFVESDFGYSPVVRMKQPATGVRRKVLKQFAPPPDDTPELQNARPIVKMFYLGTMDTSHKVDRVVKARRGLGLAESDFGVKLGQMHVQETHPGLSNAYRKLGKIIQTVGDFHAVQATAEATTLGDPLSYHSSDAFIVKETLTNRHILLRDLIQAQQATRSKRAAADRLKVSSSVRPDKVDEAINALDEAQGHEDYLTKRTQRVTSNLLAEKQRWFDRTTNDMLNSLREYTLRQIESERRTLATLESVRPDIRAIDASGGLSRLGRESHPTARRPNLGSSQGPKGDAWSGIPRRSDSLGRSLSGSFVAPTPTEDDEEVNGQGTGKGRLRSASGVSSIVEEDDDDRLDARNAASRLATSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKR7</accession>
    <name>A0A8G1VKR7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MmgE/PrpD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_451375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513519.1">
        <property type="nucleotide sequence ID" value="XM_025660579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKR7"/>
    <dbReference type="GeneID" id="37163981"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF8">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="3">
        <location>
            <begin position="269"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH55597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="450" mass="48246" checksum="35CC93BFD0730F3C" modified="2022-01-19" version="1">MATQKAAQWAASLSYSSLPPDALQAAIRSFYNWVGCTVGGSNHPAASIARNSLSRFFGSPTSTLLGTNGLQADAQHAALINGIASHVHDYDDTHLETIIHPTGPVAAALLSFAQSLDRPVSGQEFLTALAAGIELECKVGLAVWPSHYDVGWHITSTTGSIGAAVAVSRLLELNPEKTAHAIGLAATQVTGLREMFGSHTKSFHPGRAAQNGLLAAILAADGYTSSLQALEAKRGWVKVVSNDDKLTQEIDSLESNGKWELAKNAFKPFPCGIVIHPVIDGCVWLHGELQRRGLRLQDIKSVHVTVHPLVLELTGKTKPKDGLEAKFSVYHGGAIGLIHGKATPAEYEDAVVTNSETIEVRDKFVATAAENIRADECRILVDFEAPGVQIEKHVHHAVGSIDAPVTDSQLTEKFIGQCSSVLGPKQAMIISDWCWNLETKDDIRQIGQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKX7</accession>
    <name>A0A8G1VKX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_491400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512065.1">
        <property type="nucleotide sequence ID" value="XM_025663715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKX7"/>
    <dbReference type="GeneID" id="37167117"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="111" mass="12584" checksum="7A4ED57BED9279B5" modified="2022-01-19" version="1">MGLIKTGIQLAGAYGLLKAGSKAANEFQDKKQSNQNQSQNRQCSCCHHHQQPPHPQQFPPHQQAPLQQVPHHEYGYNNNTQMYPPQGGPQYMNNGPNYANPGPQYQHPEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL67</accession>
    <name>A0A8G1VL67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable beta-glucosidase btgE</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-D-glucoside glucohydrolase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cellobiase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Gentiobiase btgE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_399638</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514342.1">
        <property type="nucleotide sequence ID" value="XM_025657107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL67"/>
    <dbReference type="GeneID" id="37160509"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF24">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034738542" description="Probable beta-glucosidase btgE" evidence="17">
        <location>
            <begin position="19"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="94"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH56420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="630" mass="63257" checksum="4D815223587BFD0B" modified="2022-01-19" version="1">MKGAFLATAAALAGTALADGGAHMRRHGHDSFHQRRAVQAEPEESCGCTTEVITVWGTPTLVPAAVPTTVTSDVVTTLHSTSYTTVTVVATPGESTAPAEAATTAEGAGATGGAAGNASPSESTPAAGGATGGAAGAASGTSSTPEGVAATGAAGGNVGQVSSSTPVAAATTSSQAVVPTPETTTFSSTGVYTIPAATVTVSDTTSVVAGTTTSLASGTQTYGGVTTIVETSTTVTCPYATVSPSGSTVTSIIQTTTYVCPEAGTYTIAPTTTYVPSNTVVTYPTVSTVTPGTYTHSAITVTATVTDYTYTCPFANANEPTSTPAAATTSAVVVTTPAPATTTAAAVTSSVQSSTVASSSAAASSGVSASGNSMGMTYTPYSNSGGCKSKATVESDIETIANKGFTHIRLYSTDCSTLEYVGSAASKYGLKLILGVYISSTGTSGAQDQVTAITEWGQWSMVSLIVVGNEAISDGYTTASELATFISSCKSSFEAAGYTGQITTTEPVDIWQEYGSSTLCSVVDVLGANIHPFFNSETTAAEAGTFASTEVALLKKICTNMDVINLETGWPSKGNANGAAVPGTTEQATAIKGIRESVGELSVFFSYANDLWKDPGEYDVEQYWGCIEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLB8</accession>
    <name>A0A8G1VLB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MATE efflux family protein subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_479160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514164.1">
        <property type="nucleotide sequence ID" value="XM_025662936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLB8"/>
    <dbReference type="GeneID" id="37166338"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="504" mass="54731" checksum="AC24F01BA0AC20F1" modified="2022-01-19" version="1">MYDSLPSYRETTSAHSHGEEHTPLLPKQVDANHDSKISTLSIPCPVEFVRLLKDSIPVILAYTLQNSLQTTSVLIVGRISPEDLATTAFSLMFAMVTAWMIALGGTTALDTLASSTFTGSSNKHDLGILLQRAFFVLGLFYVPIAMLWAFSEPVFLLLGQDPQLSRDSARFLTCLIPGGLGYIYFEAMKKYLQAQGIMRPGTYVLLITVPFNAFLNYLFCYTFHMGLLGAPFATGISYWLSFVLLVLYARFIAGSECWGGWSRKAFENLGTFARLAFLGVVHVGTEWWAFEIVALAAGRLGTIPLAAQSVIMTADQVLNTIPFGVGVATSARVGSLLGSRDTAGASRAANTAAWLSMVLGGAVLAVLMGTRYDFAKMFNSDEGVVQLTAEVLPWVALFQIADGLNGSCGGCLRGMGRQHIGALVNLVSYYCGALPLGIWLAFHGWGLKGLWVGQCIALYLVGALEWAIVAFSNWECEVDKAFQRMDIEDRLEVEHTTNGATTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM55</accession>
    <name>A0A8G1VM55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_448325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516188.1">
        <property type="nucleotide sequence ID" value="XM_025659915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VM55"/>
    <dbReference type="GeneID" id="37163317"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH58266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="65" mass="7499" checksum="F1B415F3BF55F82D" modified="2022-01-19" version="1">MAKSKNASQHHNSQKAHRNGIKKPKTHRYPSLKGVDPKFRRNHRHALHGTAKALKERKEGKREIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMF7</accession>
    <name>A0A8G1VMF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Smr domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_421194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515409.1">
        <property type="nucleotide sequence ID" value="XM_025657923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMF7"/>
    <dbReference type="GeneID" id="37161325"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058864">
        <property type="entry name" value="UBA_10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26286">
        <property type="entry name" value="UBA_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="129"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="445"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH57487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="537" mass="57434" checksum="C33AD60ACFAC2D52" modified="2022-01-19" version="1">MGDKDDGPLQDLEKTYCPPLDPALLTAIVFDYDLTDSAQLGQLRETLDALRLSAWEQEDLPFDPSGTSGLGAGHGPEADASSELSESQGDRSRETDITSLTSGFSSVGIRDHVSYTIGPDGSLHLSGANEDDKIGYLTEMFPSVDRFTIQHTLKKSNGSIDRSMDVLLNLSFFDEQVPDEDGVVTVPKGVDGFDDPGAGKKQARKRKPKNKNARRQEVLSSTSSEASFENTTNKWDAAGKDVEFIHARTSAILKKETVRSTYHANGASLPATIRALADTHAPKKQIDEDPVTVTQVAELTQEFPSVPPLTFAGLLKITRSSISAASELAAAMLTSPVAPSLSEIIKITTAPPPVDVDEETPKRGAAPVTWDLNRARSAAGVHFAAGAEALSKASVAYRRGKSDRLMGGAAAYYSAVGRDHLERAKRNAAAAADALVDSQSTWNSLDLHGVSVQDAVRISSERVSEWWDSLGDAKYMRGSGASNPVQGGYRIVTGLGRHSHDGTSRLGPAVAKMLAREGWRVEIGAGVLTVVGVVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMK0</accession>
    <name>A0A8G1VMK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_372222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515529.1">
        <property type="nucleotide sequence ID" value="XM_025656032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMK0"/>
    <dbReference type="GeneID" id="37159434"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090068">
        <property type="term" value="P:positive regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04128">
        <property type="entry name" value="Spg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000330">
        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH57607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="311" mass="34643" checksum="CDD47EC45EBD32BA" modified="2022-01-19" version="1">MDASQLPVAGASDVANQAHLEQPQSLDTPAPASLGLAGPDEFTTSNGYSSDSRAHYSSHEFNSPARDFHNENDQPRQNFSPLTHQPQPLPSSRPSSEMSNSLPQPTHDISQKQPSQAAKNSVVIKVGMVGDAQIGKTSLMVKYVEGSWDEDYIQTLGVNFMEKTISIRNTEITFSIWDLGGQREFVNMLPLVCNDAVAILFMFDLTRKSTLNSIKEWYRQGRGFNKTAIPFLIGTKYDHFVNFPREDQEEISIQAKRFAKAMKASLIFSSTSHSINVQKIFKIVLAKAFDLKCTIPEIENVGEPLLLYKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN04</accession>
    <name>A0A8G1VN04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_512260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517311.1">
        <property type="nucleotide sequence ID" value="XM_025664646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN04"/>
    <dbReference type="GeneID" id="37168048"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="288"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH59389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="539" mass="59383" checksum="26AD89357F86999A" modified="2022-01-19" version="1">MPTKSLKVVIVGGSIAGLLLANALARQGIDFVVLEARSEAAPCDGAGLCLLSSGARILDQLGMFEDIQYHGGPISVQRIWRDDGQLLGHTEGLALITARYGYPVIFIERQRVLQVLFDHIPDKGRVLLGKRVIEITSSDDQGIVMCLDGSTYQADIVVGADGIHSITRRKMLRDIISDSPKSHIMPEALGRVFSAQYSAVFGISKPTPGMKIGHCNRTFAHGFSFFNAVGRNGQIFWFVFRDMGKVYGEKDIPRLDQSKIEEDMAPFFNKYVAEGVRFRDIFENRVRCSHVPIEEGFLNQWVWKRYACIGDSVHKTTPNLGQGGNGAMESAASLANTIVAMAQASISSDLSLPRISTSLKDWAGSRQQRMRLLCELGNGFTRLEAFHTLKDRVVGFYLGKYQLDAIADILCETTVGAEKLSFLPPPQRSLQVTMPFDTRKGIQAATRTNSLILRSLIAITITFAVPPLLQHYIAGRIVDHSPILHKQNGLAYEDDGSYTYHKSTETLAAMSRIADLGVLLTIWAVESCRTGNIATLMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN06</accession>
    <name>A0A8G1VN06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL30m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_519957</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516009.1">
        <property type="nucleotide sequence ID" value="XM_025665091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN06"/>
    <dbReference type="GeneID" id="37168493"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000010">
        <property type="entry name" value="Large subunit ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_uL30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="9">
        <location>
            <begin position="85"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH58087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="175" mass="19917" checksum="A95D4743E841A4B4" modified="2022-01-19" version="1">MKTRDKLTNGSPSQRMFQNDNRYKDTQRIAKASQRAAFASPENNSTSSKPAGSLTVYVTILRNLPTKYLRTKQTNPQTARMSSYFRVTLMRSAIGLPRRTNDVLKALGLKKRMATVFHPVSPSVAGQIMKVKELVQVQEVDRRLTKQEVHLERKPDPGYYVEKTSGVEFEENRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN78</accession>
    <name>A0A8G1VN78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_519204</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516219.1">
        <property type="nucleotide sequence ID" value="XM_025665030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN78"/>
    <dbReference type="GeneID" id="37168432"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03002">
        <property type="entry name" value="PDI_a_MPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041269">
        <property type="entry name" value="QSOX_Trx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057305">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18108">
        <property type="entry name" value="QSOX_Trx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24541">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034833003" description="protein disulfide-isomerase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="14"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="243"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH58297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="465" mass="50358" checksum="6A7FEF9900978B2B" modified="2022-01-19" version="1">MLQPSSALLFVTSLLAALPVNADGLYTKKSPVLQVNQKNYDQLIANSNHTSIVEFYAPWCGHCQNLKPAYEKAATNLDGLAKVAAVNCDDDDNKPFCGRMGVQGFPTLKIVTPGKKPGKPRVEDYKGARSAKAIVEAVVDRIPNHVKRATDKDLNTWLAQDEESPKAILFTEKGTTSPLLRALAIDFLGSIQVAQVRNKETEAVEKFGITEFPTFVLLPGGGQDPIVYDGELKKKPMVDFLSQAAAPNPDPAPKGTTAPRDNNKKKSTESAPDAKVAQDDDTKPASVPIPAPPIDTLPTAEALEAACLMPKSGTCVLALLPEPSEPDADLPAPAKDALLSLAEISHKHAVRKSKLFPFYSVPAINSGAKTLRAGLGLPEDNSVEIVALNGRRGWWRRYDSVEGAEYGQERVEAWIDAIRLGEGEKQKLPDGVVVEEVVEEKVEEKVEEVVEEPVEEKPAVDHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN86</accession>
    <name>A0A8G1VN86_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_272282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516249.1">
        <property type="nucleotide sequence ID" value="XM_025655103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN86"/>
    <dbReference type="GeneID" id="37158505"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="312" mass="33376" checksum="E61EE958E1BA2E45" modified="2022-01-19" version="1">MGGKSATKAAYFEKLKALLDEYKTVFIVGVDNVSSQQMHEIRLSLRGEGVVLMGKNTMVRRAIKGFVNDNPEYERLLPFVKGNVGFIFTNGDLKSTKEKILANRVAAPARAGAIAPGDVWIPAGNTGMEPGKTSFFQALGVPTKIARGTIEITTDLKLVEAGSKVGPSEATLLNMLNISPFTYGMTIQQVYDQGQCFSSAVLDIEESQLLEAFSSAINTITTISLAVNYPTLPAVMHSLVNSYKKVLAVAVETEYSWPEIEELKDRIANPDAYASAAPAAAAAPAAGGAPAAEAPKEEEEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN99</accession>
    <name>A0A8G1VN99_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_447561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517596.1">
        <property type="nucleotide sequence ID" value="XM_025659748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN99"/>
    <dbReference type="GeneID" id="37163150"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF38">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G00240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="2">
        <location>
            <begin position="26"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="333" mass="37839" checksum="2E906123E4B38F3D" modified="2022-01-19" version="1">MLSNKQAIGTLSLGQHPSHTLDKKIRVASQHGFTAVEVVYSDLKRYSDALGVSMLEAAGKIKNVCDDLNVEILSLAAFENFEGNRTPLDERMTTAKHWIDIARELNATYLQVPSNYSHDASTDKNLIVSDLQQLVDLASAEEPVVSVAYEPLSWGTYCSTWDTALELVEAVDRKNFGLCMDTFHEVTKLWASPFETSGKYPTADKDLTASLVRFLKQCPLEKIFYVQLSDGELFNPPFSKAHPWYLEGEAPQFTWSRHARPFPFETELGGYMPVLEIVKAWVVDKRYTGWISMEVFDRRMRSEEFNPEDAGKRARKSWETLQDRLRSPTPSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNG1</accession>
    <name>A0A8G1VNG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sialidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_510789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517688.1">
        <property type="nucleotide sequence ID" value="XM_025664567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNG1"/>
    <dbReference type="GeneID" id="37167969"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021829">
        <property type="entry name" value="DUF3419"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473">
        <property type="entry name" value="BTA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473:SF1">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11899">
        <property type="entry name" value="DUF3419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="830" mass="94646" checksum="5B2A9F78A75F4831" modified="2022-01-19" version="1">MSSSSATGPFWGRLNWLHVYIAGTAFAVCAFVAVVMMLSSQKRKIDYNSGVFTYLKFAYATFLKPHEKHGNGQQDALESFYKTQAGVYDATRKRLLRGREDMLGLVAAQLKHKVENKQLQSGKAVWVDIGGGTGYNIEAMSAFLPVKDFFSRVYLVDLSPSLCEVARQRFERLGWKNVHVVCQDARSFRLPEDDKVDPRNESSAGADLATMSYSLSMIPDYYSVIDALPALLKPTGVLGVCDFYVQSIVDVSSRNYTGGAFNRHVNWLGRVFWRAWFDVDRVSLEAARRDYLEYRFGTVISASERNYLLGGIPYYIFVGCQKDSTTHSGREAIEKLNASFTESPYLSPANHRKEMETAVVNSTQEIRSKAYESAVINLSANLPLPSSFYQNHHHRIFYNDLLPKHTQFGNEYIYAFNWEDPRVDHRLLDIKRDDVILAITSAGDNILDYLQKSPRRVHAVDLNPNQNHLLELKVASFMALGHRDVWKIFGEGKHPEFRNLLISRLSPHLSSQAFQYWLEHTHIFTSSSGKGLYETGGSRHAIKMVRYLFKVFGLESQVRQLCEAQTLAEQRKIWPRIRSVLMSKPLHWAVVGTEWFAWKAAGVPRNQRNMIIDDYFKRNGLNKDMKQAKDVSGKSIWEYVVDTLDPVVQDTLISNDNYFYFLCLQGQFSRRCHPAYLSPKAHVKLSSPGAFDGLRIHTDEINEVIKRIKPRSLTIAVVMDSMDWFDPEGEEASIQAQKLNHALKMGGRILLRSASIEPWYIQHFEQNGFSARRVGARFPGTCIDRVNMYASTWICTKTQELERPAPSRAMSALSLDNITPKRNSVEHLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNH5</accession>
    <name>A0A8G1VNH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate permease-like protein, Mch4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_477391</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516712.1">
        <property type="nucleotide sequence ID" value="XM_025662835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNH5"/>
    <dbReference type="GeneID" id="37166237"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF240">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="48"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH58790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="440" mass="47348" checksum="ACA13187EE474073" modified="2022-01-19" version="1">MADIETHVCHSLDQGAHATIEKSASQVIATEEQDDTFDEKYPEGGLQAWLVVLGSWCAMVPSMGLLNTISVLHAWTSTHQLSEYSESSVGWIFGVFSFFLYFAGAQVGPIFDSRGPLPVVVPGSIGLVVAVFCFSESTEYYQIMLSFSVLGGLSSCCLFTPAISAIGHWFNVRRGIATGIACTAGGLGGVFFPLIILYVAPKLGFAWAMRIIGIICFVLCGCACLLLKTRLKPDAKRGMAIDLRALREPNYALTTLAVWMVEFAVFVPYTYLCSYGLYANIGESLSYKLCIFLNVGAIPGRAFPGLLADRFGRFNVMAFTALVCAIMTLALWYNAGTNDAAIIAYSVMFGFWSGAAISLTPVCIAQVCRTEDIGKRNGTTFTLVSFGTLTAIPIAGAIQERDGGAFWGLILFGGILYLAACAAFVVARGVAGGWRLRTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNJ1</accession>
    <name>A0A8G1VNJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_278921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516579.1">
        <property type="nucleotide sequence ID" value="XM_025655173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNJ1"/>
    <dbReference type="GeneID" id="37158575"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="119" mass="12867" checksum="D7709CA18191560F" modified="2022-01-19" version="1">MLDAGNVCEFGYGRESEEKKNLSLSCSFFSIVVVAAANISLAPNNCSDNLSLSSSSSIYPRNVFFNSRPIVDCTRTPSVDDTGKNREGSKSRRINCNKLTSNPAALHQERSGQGSLGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNN0</accession>
    <name>A0A8G1VNN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">2-methyl branched chain acyl-CoA dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">2-methylbutyryl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">BO85DRAFT_366789</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31 32">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156439"/>
            <dbReference type="ChEBI" id="CHEBI:156440"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:65297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65344"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156457"/>
            <dbReference type="ChEBI" id="CHEBI:156458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:65345"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="16"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517986.1">
        <property type="nucleotide sequence ID" value="XM_025655793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNN0"/>
    <dbReference type="GeneID" id="37159195"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01158">
        <property type="entry name" value="SCAD_SBCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="27">
        <location>
            <begin position="3"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="30">
        <location>
            <begin position="330"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="29">
        <location>
            <begin position="445"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="28">
        <location>
            <begin position="552"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048592"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="RAH60064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="707" mass="78310" checksum="0EA0E6AF30D4E8A3" modified="2022-01-19" version="1">MARFQIVSDLHLENPKAYDLFEIAPKAPYLALLGDIGNVRDDGFLLFIEDQLRKFEIVFLVMGNHEPFHSSWLDVREKLKRFSDDITRKGAQMQNTKSGSHNLGKFVLLDQTRYDLAPDLTVLGCTFHSKVSDMQEERVSFGLNDFYYIKNWSVEDHCAAHEADRAWLNDQVTEIARSNPHHRIVIFTHHSPTVAPLAVDPAHAKSPISSAFATDLAGEACWEKPQVRLWGFGHTHYNCDFTDSRTGKRIVANQRGYYFSQAKVQFHFDMASITRALRPLSRTATSARLIARPPLSARLAVSSTHAFSTTSRRRDVDLSGLTPTPITFLSETESLMSESVNKFAQEQISPKVRDMDEAETMDPAVVEQLFEQGLMGIEIPEEYGGAGMNFTAAIVAIEELARVDPSVSVLVDVHNTLVNTAIMKYGDAQARRTWLPKLATGTVGSFCLSEPASGSDAFALQTKAEKTADGYKINGSKMWITNAMESGVFLVFANLDPSKGYKGITAFIVEKDTPGFSIAKKEKKLGIRASSTCVLNFDDVLIPKSNLLGEEGQGYKYAISILNEGRIGIAAQMTGLALGAWENAAQYIWNDRRQFGQLIGEFQGMQHQVAQAYTEIAAARALVYNAARKKEAGQDFVQDAAMAKLYASQVAGRVAGSAVEWMGGMGFVREGIAEKMFRDSKIGAIYEGTSNIQLQTIAKLLQKQYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNT7</accession>
    <name>A0A8G1VNT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CENP-S associating centromere protein X-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_446804</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-X/MHF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518181.1">
        <property type="nucleotide sequence ID" value="XM_025659583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNT7"/>
    <dbReference type="GeneID" id="37162985"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22921">
        <property type="entry name" value="HFD_CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018552">
        <property type="entry name" value="CENP-X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09415">
        <property type="entry name" value="CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="19"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH60259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="22756" checksum="B18DA16F57780ABE" modified="2022-01-19" version="1">MPPERKPAQKRRQLPFKPPSRTSSTAAAPASSSSTAAAATSKPKAKATTKSTTTTKRGPKPKEAPAKASSSKSARPRPSSPSPADSQEDSDNDNDNASSSSPAHSDASSPEPEPEPDYILAEIVHKDQPSDDVLTNDPVIPPKLLTRLLHHHFQNEKTKIAKDANTVVAKYVDVFVREALARAAFERTEAVGKGASIGDGFLEVCFFSPLCVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP29</accession>
    <name>A0A8G1VP29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of G protein signaling domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_369173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517342.1">
        <property type="nucleotide sequence ID" value="XM_025655906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP29"/>
    <dbReference type="GeneID" id="37159308"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF267">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="80"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="367" mass="39821" checksum="19572575F5F54FFB" modified="2022-01-19" version="1">MLKKKTLHPPILFRHHTPSTTPELSPTSSSSDSESDEDMDSSGSRPLSLTVPPGAFCPMRPSLDEVLANTAPAPYTLSAFMAYLSQNHCLETLEFTLEAKRYRETYDALSRQLNESPIVTDCTGSQHLRMLWQRLLTAYILPGSPREINVSSEVRDDILRHANLPNPPLPETLDAAVKLVHDLMEESIFLPFLNSHASTAHVLPLSEPLFSQEDDITVVSNSSFDEHTASRGRSKRRRQSPQSSKDLGSPVSVGSPPSRSNFSLSAMTSMGKVGHRTLGQVSNASGDSGSGALTDDSGSLQSSASAGEPMTPPTTPPSSDPHCMHLAHSPKRTDNPWKKMGLKLGFKKRSGHGGSGNQHFKLSGMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP52</accession>
    <name>A0A8G1VP52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="16">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO85DRAFT_459471</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="16"/>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515320.1">
        <property type="nucleotide sequence ID" value="XM_025661659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP52"/>
    <dbReference type="GeneID" id="37165061"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 19" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="20">
        <location>
            <begin position="8"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="87"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="306"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RAH57398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="409" mass="44466" checksum="5641619C8182ABCC" modified="2022-01-19" version="1">MSTTAQPPPLSSILSAQDFEKAASQSLTPKTWAFYSSAATDTITHESNRAMYERILLRPRILRNVTSVSMKTNILGCRMDLPLFMSPAAMATLVHPDGELALARGCARYGIGMCVSTNAAYHLSEITSAAAKQTKNNNTPFFFQLYVNKDREASKRLLRTAEQNGAKAIFVTVDAPVAGKREADERVPLDPHDIRFRTPLPMSGACIGGNDEKGGGLGRSMGQYIDAGFTWEDLAWLKENTFLPIVLKGVQTAEDAVLAMEYGVNGIVVSNHGGRSLDTSTSSIAVLMEIRRSCPQVFDRLEVFVDGGIRRGTDIIKAICLGAKAVGMARHFLYSLCYGQDGVERLIESVKVGMLTVAVMRDELETTMKLLGITNLSQAHPGLLNTLDVDHLIPKQSASLDGEPARARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP69</accession>
    <name>A0A8G1VP69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class II aldolase/adducin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_395011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517254.1">
        <property type="nucleotide sequence ID" value="XM_025656941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP69"/>
    <dbReference type="GeneID" id="37160343"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF25">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AraD/HMP-PK domain-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="56"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="294" mass="32369" checksum="1C1BD8EA7BE56ABF" modified="2022-01-19" version="1">MSSTTTTIVAKKEDPSQATESNTTGKSAIQAISQGATLPGIPSFTSADKKRRWMLEHMAGAFRVFARKGFSEGMSGHISLRDPEHPDCFWTNPLGLHFGLVKVSDLILLNDAGEPVGGNRSRPANAAGFQIHGVLHKMYPHVNAACHAHSKYGKAWSTFAKPLDMINQDVTMFYGDAQAVYPEFGGVVLEKEESLRLGRHLGDKGKLLILRNHGLLTVGQTVDEAAYLFTLAERSCEIQLQVDAAAAQGLEKKLIEPEAAEFTFKMTSDPEALYHEFQPDYEMERALCNDQFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPV4</accession>
    <name>A0A8G1VPV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_468687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516025.1">
        <property type="nucleotide sequence ID" value="XM_025662284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPV4"/>
    <dbReference type="GeneID" id="37165686"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="326" mass="36326" checksum="26F52E76CB121D5E" modified="2022-01-19" version="1">MSRLPLPIPPPIPATYTPKSHLRTIPSTTPIEYILAILSRDGGVIISDFIPREDLTAIDTELTPWTSASTSTKKPTSTSTTNGAFTTIPSQTTLIPGLVGKSPTIARITAEHPTLEALRTRILVDEWCINREDSVEPNRLDPLLSLSVAMNIGYGAPRQLLHRDDNVHHVRHEYREWEWGWDQVSQFGCLIAGCDVSREMGATMFVKGSHRWGDERWAEFDHDKGEVCFAEMKAGSALIFLASAYHGGGHNSLPGTVRNMYGLFFCRGHLRTEENQFLAIPRSVVTKMSPKMLELLGYKKPTTALGIVDNISPHEDVEGVWERVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ70</accession>
    <name>A0A8G1VQ70_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_466972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518379.1">
        <property type="nucleotide sequence ID" value="XM_025662162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ70"/>
    <dbReference type="GeneID" id="37165564"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="229" mass="25147" checksum="05F69D60BA0E57FC" modified="2022-01-19" version="1">MDKITETERLDQASVRPELDTDTESKRWAQTLLQSETSGTTELKQSAQTSLLAVTTDQGSLGQGGSNSGNDRSNDGLASTTAYTNEERITSSLTEGLLARALFTSSVEEESPSGSSASSDYGAVADTHRGIPPFFGEKSDSDLSSYSDYDEYDSNSEPRGEWSGIYDESYDADEEDWSQSGEGDSEDWDDTEQEESEVNPNLNERFLRVVRSPPMRHRRPLPGQGKRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQZ0</accession>
    <name>A0A8G1VQZ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_131949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520253.1">
        <property type="nucleotide sequence ID" value="XM_025653995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQZ0"/>
    <dbReference type="GeneID" id="37157397"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="121" mass="14419" checksum="5E36FA66410DBD7C" modified="2022-01-19" version="1">MFQANPLVAYSCIRFIFRPLTAPALPWTHLIFSYLACRCPIECDRKKKKKNNWRQYANWPKIRTCSKLSSARHLTHFSPVEQELLQYPQSWLELLHAKHVSSSCIRVFRAQHQSERRADQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR41</accession>
    <name>A0A8G1VR41_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_458525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517330.1">
        <property type="nucleotide sequence ID" value="XM_025661590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR41"/>
    <dbReference type="GeneID" id="37164992"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23132" checksum="6BCD2AEAB9DDCA61" modified="2022-01-19" version="1">MADAWLRHVRYYNGILSHIITDIQIGQFLNPKYSNLSIKCGNEIFPAHQNILCPQSNRYHEVDANNYRTATVRSSLRIAIPPKNSSECSPQTWTENDEFDADTEQYSKPSRKPNTTNLQSCHAFFHAQIYAQVYSSTGEHDRGLRDLVVQLTTDNLKALRSGDDPIFCNSLLASVPNFMLDICLSTLDRCAEYQRQQARIWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VS92</accession>
    <name>A0A8G1VS92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_5719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520627.1">
        <property type="nucleotide sequence ID" value="XM_025665497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VS92"/>
    <dbReference type="GeneID" id="37168899"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="74" mass="8584" checksum="8840E976404318CB" modified="2022-01-19" version="1">MRPDLKSNTNCYVSPRKSFPVERGWIRSAVSRCNLNSIRFSCHDVLGNWVLMIHFAFPQLPETMGVCLELTTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSV9</accession>
    <name>A0A8G1VSV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oleate delta-12 desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_364965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519130.1">
        <property type="nucleotide sequence ID" value="XM_025655720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSV9"/>
    <dbReference type="GeneID" id="37159122"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="3">
        <location>
            <begin position="126"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH61208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="466" mass="52297" checksum="812840A0EB31C0B9" modified="2022-01-19" version="1">MSSTALPKRVALHRNATDSSVPSSVTPSPLDSPRQSPSSTSLSSLASEAEASGKMLDTYGNEFKIPDYTIKQIRDAIPAHCYERKALTSLYYVFRDVFWLATIFYVFHNYVTPETVPYKPARVVLWALYTIVQGLFGTGVWVLAHECGHQAFSPSKVLNDTVGWICHSALLVPYFSWKISHGKHHKATGNIARDMVFVPKTREQYASRVGKALHELNELMEETPIATAFNLLLQQLFGWPMYLLTNVTGHNNHERQPEGRGKGKQNGYFGGVNHFNPSSPLYEAKDAKLIVLSDIGLAIVGSILYLVGSKFGWMNLLVWYGIPYLWVNHWLVAITYLQHTDPTLPHYQPDVWNFARGAAATIDRDFGFVGRHIFHGIIETHVLHHYVSTIPFYNADEASEAIKKVMGSHYRTEAHTGWTGFFKALWTSARVCHWVEPTEGAKGESSGVLFYRNTNGIGVPPAKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSX3</accession>
    <name>A0A8G1VSX3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_446419</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519175.1">
        <property type="nucleotide sequence ID" value="XM_025659502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSX3"/>
    <dbReference type="GeneID" id="37162904"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="7">
        <location>
            <begin position="239"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH61253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="300" mass="34607" checksum="D3BB9A2A3C23355E" modified="2022-01-19" version="1">MPFHKLVKNSAYYSRYQTKYRRRREGKTDYYARKRLITQAKNKYNAPKYRLVVRFTNRDIITQIVYSEISGDKVFASAYSHELKRYGITNGLTNWAAAYATGLLLARRTLKKLGLDEQFPGVEEADGEYTLTEAAETDEGSRRPFKAFLDVGLARTSTGARVFGAMKGASDGGIFVPHSESRFPGFDIESEELDAETLRNYIFGGHVAEYMEGLADDDEERFRSQFHKYQEAGVEAGDIEELYTEAHKAIREDPFKKDEDAGEKKTKEEWKAESKKFRPQRLTREQRKERVEQKIRELAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QPL6</accession>
    <name>A0A8G1QPL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_432649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509818.1">
        <property type="nucleotide sequence ID" value="XM_025658389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QPL6"/>
    <dbReference type="SMR" id="A0A8G1QPL6"/>
    <dbReference type="GeneID" id="37161791"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH51896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="275" mass="30027" checksum="75CBCE2CB2CA58DF" modified="2022-01-19" version="1">MGCITVGVLALQGAFYEHIQLLKSAAADLPAKDRSSASQWDFIEVRTPQELERCDALVLPGGESTTMALVAARSNLLEPLRDFVKVHRRPTWGTCAGLILLAESANRTKKGGQDLIGGLDVRVNRNHFGRQTESFQAPLDLPFLGANQPAFPAVFIRAPVVEKILPHQEGEQVAEAQREETVIAPARQAEDEVARQAMADSVEVLAALPGRAARLACQGTPINADDETGDIIAVRQGNVFGTSFHPELTDDARIHAWWLRQVEESVKKRHAAHHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQF5</accession>
    <name>A0A8G1QQF5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metallo-beta-lactamase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_509861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825094">
        <property type="protein sequence ID" value="RAH51753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509675.1">
        <property type="nucleotide sequence ID" value="XM_025664513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQF5"/>
    <dbReference type="GeneID" id="37167915"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="44"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH51753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="378" mass="41869" checksum="6F3D39733DE9D5FA" modified="2022-01-19" version="1">MAPLLPYDMGTIVEVSVIHAGRTTVPTAYVVDRPIAGHNVLDMPCYSFLIENRRLNKKVLFDLGIRKNWKEKLPPSTNVSPLYMLMVIEQKVLHQIQSAKALVDIEQDVADQLRNANVPLESINAIIWSHHHMDHTGDPSLFPPSTDLIVGPGFNRNKRTFPGYPTNADALVTDDAFSGRSLVVLDFWNAMTIGGFLAIDFFQDGSLYLLKSTGHTHNHISALARTSKDRFIFLGGDIAHHPGEYRPTKHLPLPTEIRPSPLGEEISSPSVCPGSISEAVSSANIRGLDAKVTPFYQLNAAMNEDLKDAEIALEKLLRFDGSSKVMVIISHDASLLDVLPFFPRSINEWDVKGYKAEGTWRFLRDFARAAGGTTDESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQV0</accession>
    <name>A0A8G1QQV0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_453925</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the TIM23 complex, at least composed of TIM23/timX, TIM17/timQ, tim50 and TIM21/timU. Interacts with preproteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510538.1">
        <property type="nucleotide sequence ID" value="XM_025661160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQV0"/>
    <dbReference type="GeneID" id="37164562"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="17">
        <location>
            <begin position="235"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="35"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH52616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="520" mass="58869" checksum="7CF679D18C1DCACE" modified="2022-01-19" version="1">MLSRAVLPLTRPNVLTSTVRASTISVAHSRWYAKSTKPKTPYKLPESVKSAKSEQSPKAPSQNDYSAEQAEFDTKAEPEPATEASQTGSTAPQNDAPQKPLPDLTQGIPSTLAAELEAASKNRGPSKLNLTEDPSRAEDYDDGGRDISNYESSLDRKRARMANLMYVLFLLAGAGGVAYLGRNWETEEEEKAHPDVPSGWGFGLMYNRAKARLGDITSYYKDPAFPKLLPDEDPNMRQPYTLVLSLEDLLVHSEWSREHGWRVAKRPGVDYFLRYLNQYYELVLFTSVPSMMADQVLRKLDPYRIIRWPLFREATKYKDGEYIKDLSYLNRDLSKVILIDTKEEHARLQPENAVILEKWLGDSKDKTLVGMIPFLEYIAGMGVEDVRPVIKSFEGTQIPVEFAKREKAMRERFEKELAEEQKKRPRSGLGSFASALGLKSTRTLDGEQSPSEGLAQGKMLWDQIRERGQKNYEMIEKEIRENGEKWLAEMAAEEEKARQEQMAMMKGSFTGMFGAGPKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRV5</accession>
    <name>A0A8G1QRV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_463860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510386.1">
        <property type="nucleotide sequence ID" value="XM_025661946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRV5"/>
    <dbReference type="GeneID" id="37165348"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47885" checksum="B0360C4258AA6B8F" modified="2022-01-19" version="1">MEQPDYILDEEGEILIGLVYPNQPFVSFEPGVAREAGSQVVDSELLQRWIAMATDAGIMEEKYKKLSILPLIVQSDNQVEASEPESGIWGIGGPPVDILPSSLLTEEERQARRRIREDLERRLQARNDESQSETETVVTFQASAKHLMTASPYFKALLSTGMEESVEFQADGTVLTTAECWDDCAFLYVLKIIHCKSHELPDKVDLDMLGKVCVIADYYDVSDAVRFAARPWIAKLNPYGPDDGYRDAVNWLWISIFFRMPGVFKAASLNLIKEGRAHMPPLGLPIPAPIVEEINARRIKAIEGLMGHVYRVQEEYLTGKRGCSFECSSMLYGALTKNLNTHNLAKSDFKAPFLYHNYNSLVNIIDRFRQPRWYDPRSSKYLCWQYLEHECHDAHFWELRLGRFLDEDGLELMDFVQTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSP0</accession>
    <name>A0A8G1QSP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_492090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511498.1">
        <property type="nucleotide sequence ID" value="XM_025663760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSP0"/>
    <dbReference type="GeneID" id="37167162"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH53576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="699" mass="78335" checksum="079543FE45A16B6B" modified="2022-01-19" version="1">MADAISPAQPSGWRIPKACQECRKRKIKCNGVNPCKTCELRHTPCIYREVIRQRKKKHQYTEAPANDEYISNGATRADYGARQQSPGVMQPARRRNPSVSLTFNNSVSATHMASPSCKVQLYYGSTSHFALMHEIYRGLVSGNQSAETEEPQGEVEEAGAGLDMFSFRRIFFGTQADSHDSNKALNGPDANVLFLPYDLAKVFLERFLATLYHLVPFWSKEVFYQQLDHLYRPTPDSRSDKWARSLLLLGLATGSLGTQHHSWGDILYERVKASISSLDDVVNLQTHAHFQTEQGRPNSAFLLIGVAARKAISAGLHKEAPAESDDAADSVEERRCTFWSLYFYEVWTCFHLGRPRSLSAKDIGIALPKDPFLQVLVHLSKIFSRSADEMYGRRHESLLQMWKIAKSITDDMRCYDSKMQHALGFGLDKPVQPGTLGVRQTILITLYYHTILLTFRPFLIFRGRWQHQMKISSQQPGSSTAKGPTEIPTWLNEACNQALSAACRTIHHLYEASIYNELVRELRYHGYFLGSSSFALIYDLMHGENLASTHLPWIHAALQGLSSMRHGEPITSSMSAIQTVLRKLNPSYEWSPGAMPKGNSYNIDQASAVRRYPSSVAHQPQGPIPDTLQSDLAGGGLSMLSDFQGNSLQDGLRMPSGSLGSGEDLLDFTQSDMGWDFDFSTMDLEAFFSINPTLDPPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSV5</accession>
    <name>A0A8G1QSV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoflavone reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_523342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511588.1">
        <property type="nucleotide sequence ID" value="XM_025665339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSV5"/>
    <dbReference type="GeneID" id="37168741"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH53666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="321" mass="35999" checksum="4AB9DD6A285890B4" modified="2022-01-19" version="1">MGTPITVGVIGATGNTGRSVVDGLLSSPIKFAVTSFTRQASVDSQANNTLKAKGVHIVGYDLDGPRQVLVEQLKSIEVLISCITWEHLESQVPWIEAAKEAGVKRFVPSEWVGPAPRGIIDIKDKKLDILGVIQRVGLPYTLIDVGCWFQVWVPKIPSGQSDHAHSIYIDHRIVGHGNQKFGLTDMGDIGKYVAQIISDERTLNRRVFTYTEVLSMNEIWDTMATVSGETPLKEIVSESEIKEIIQRCGKRWQENGEKVDIMDVANYNMGQYRISWCIRGDNTPEYADYLGYLEFWKLFPDFPKGRSLKAYYQQVLTEGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTA1</accession>
    <name>A0A8G1QTA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_384583</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510106.1">
        <property type="nucleotide sequence ID" value="XM_025656557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTA1"/>
    <dbReference type="GeneID" id="37159959"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="270"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH52184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="640" mass="71119" checksum="C3B24DD23326EFBD" modified="2022-01-19" version="1">MQMEGMSGGTYYGVLHASDVDFANITQVETFLHELKHLEYLPILGALYAEYFWYGVIVLLVVVAVINRVYSLVQRLRFYPSITYKSCLANITSTTLATTTALVREPSYLQWTPRALSPWFKIPPFGPIYIILIYFVFIIVLEFVNNDVAGAGYWQFLGVRAGWLAAAQIPLLVALAGKRNLIGMLCGIPYVRLNIYHRWVSRGLLLLSTFHFAFQNHGWDIYHISRLEWDTDDCPTKGIAAYAFILWMNLTTLAPFRHMSYEFFVVQHIITFFGFIIALSYHLDTSPAPNAQRYVFVTAGIYVAGLILRSFYYSYINSRPARAILEPLEGGATKVRITARKIRNWKPGSHILLSLPRLGLQLSHPATISSIPSSHDGELVLFLRAHKGFTRKLINTAEATSNCSKDVESPQTKRSYTALLDGPYASSAPDFTSFDSALFLAGGTGVTFTLSQLLHVAHRSTKGPLPLRQVLFIWVIKESRQASWVLAELEAAMQKLQHTNIQIRVKIFITQDSVCLPDTDSKTNNEKQTCACTDPCTCSNNSDDVDKIEQIAPSSPCTDPDSALETSGPPRISFAQGRPSFDGYIEDAVLQARGEIAVAVCGPIGLTVSVRQAVVRVSDHLAVCKGSGLPGVFLHVENVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTS1</accession>
    <name>A0A8G1QTS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_471829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511430.1">
        <property type="nucleotide sequence ID" value="XM_025662510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTS1"/>
    <dbReference type="GeneID" id="37165912"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="232" mass="24582" checksum="768822C222B5938C" modified="2022-01-19" version="1">MAPTILFVPGFWEGPKVFTPVCDLLQADGFKTEVCTLPSTGTTSPGNPAMTEDIAAVRDHLTSIVHRGEEVILVLHSAGGFLGSAAMKGLSKSAVGQGGVVKIVFLAAAVFPEGHEHEDLPFAVVEGGAMYCVNPEVLLLNDITEPEKTKWLAMLAPQPADDWNGRVPYAGWRDVPSVYLVCEGDNALPADLQEQLANLAGSQIERCSAGHMPQLSQPSRVAEVIRAAAAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUZ1</accession>
    <name>A0A8G1QUZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_472207</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511006.1">
        <property type="nucleotide sequence ID" value="XM_025662538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUZ1"/>
    <dbReference type="GeneID" id="37165940"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF5">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="427"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="829" mass="92538" checksum="DA96925B7042F456" modified="2022-01-19" version="1">MFGIINLPSRSTGTLSSASSSKKRYAPIVNELLQLLDKSFPYASGMEALEQAIQSALQYRIVEMESYGLTSAKGFLNFATWMVDGWIPTESAKGRDIYYILCIFYFVFDQVPLKDCQTAIRPESVGQDLSELSQWMVKFAKEVGSHMNRPESLNEASLTSFWNAPSFHVFEADESKTEGGKWTNFNQFFCRHLKDGARPIDGEGDDNIVIFPADSTFSGYWDITDESMVELKGLPWHIGDLLGPYKSDYGDSFKGGIWLHSFLNSFDYHRQHAPVGGTIKVIDTIDGAAYLDVEYQPDSRSLMPKRPMRPIYSSGPVYRGAEATDKEGYQFLQARGIIIIENDKIGTVAVLPIGMAQVSSVVVRDDLKPGATINKGDEISHFEFGGSDIVVMFQGGKIDPHTLPQPLSRKSEEPLYEHHNYGEMLAKANESVGEKKRKPVRRDPEKRRQQNIQAQRRYREKLRERLGRLEALAESAGQTSAIESTPASGIQPSGAITAPGLPIASSTIVSKTLPLYDASDVSIPCTSGATLSNCQELIPISGGIPPTLYTSDSTTTPYLYSDESPSTLSVWDPPSCVDPSLLVRDKPSDSLELYWTTTIDCGCTSPHFRIQTDGPDLLGRNEVRVFRFGANTTTADPYTNSLRIDRVCTIAAILDLVRHLGITEEGLCADQSPSPFFRPSAVMADDTARSNLIRTVQETFKTLKPDLRPSQEQITIEHHPIIDILPFRTLRRNLITRQHDIDEDEFFEDMLSGLVCWGGAGIGKRDRQVSTGYASTGTPWDVRSWEGKVWFLKKYWALLGGEDGELVRQSEWWRSIRGDESEQENMWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUZ9</accession>
    <name>A0A8G1QUZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_156355</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511274.1">
        <property type="nucleotide sequence ID" value="XM_025654195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUZ9"/>
    <dbReference type="GeneID" id="37157597"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="5"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="41"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="250"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="283"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH53352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="341" mass="35337" checksum="3233195F330B2243" modified="2022-01-19" version="1">MAPPQICVIGSLNIDFVTYTPRCPDAGETLTANSLAISAGGKGANQAVACGRASFASKDNQDASVYMIGAVGAGDPYYSALLRPTLEGSGVSTTGIQEKTDSQTGSATIIVDEGAGGENRILFVPGANYSGMDNADAVLATTRNIHLEQGVVVMQGEIPRSTTLELMKHFNSASCASHLVFNPAPVFTEGIPLAALAGTSVLAMNETEAVLMTQAVKEHLTPAQQEKDLKPEELAPLFHKHAQVQIVLITLGAKGAYYSTATGKQGFAPSAAVEKVVDTTAAGDTFVGYFATAFAKFVATGAPLADFDAQIEAAVRKANVAAAGCVQRKGAMQSIPFAYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVJ7</accession>
    <name>A0A8G1QVJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_491156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512360.1">
        <property type="nucleotide sequence ID" value="XM_025663698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVJ7"/>
    <dbReference type="GeneID" id="37167100"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034141638" evidence="1">
        <location>
            <begin position="27"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="430" mass="47246" checksum="59FF4A11C9BD78ED" modified="2022-01-19" version="1">MYSPTLSWSHAAILFLSLSSFQFGTASPIDGQLIERSGVASPGIGVEFESGSIYFTKDVHKLSEKEKEAVKEAGIAAKGKAVKLKSAKDGNGAELSGKDWELTADATGGTLGHLPAEYILDGRKIKLGTGRAALAAEEVYEDLKKWNPKTGQEVEIASNKKNPWSVKAGTNPVNSAWSRQITSPMPLGAINDLIKQAKLNKPSPLMTYANSKIQNKVWVNDFFFEEKPGGLTKDVGEDVRGFLSLLLSYAKAGSQVRNSESAKELTSIMPRTSFSKMYKLIESKLEKKDLWTIVNKLACYENPIDDAHEYAAVDERYCSGHPGQTTINGKFEKLQINVCYGSQSCPVNVKAWIQGLKDGKDLLKDADKEMIDGQVGGYGDLTEHRLDHPTEQLPLFEFRDLPSCSASEWKKCLEKAEAAIVDYHKKFPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVX3</accession>
    <name>A0A8G1QVX3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Ran-specific GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_462991</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511516.1">
        <property type="nucleotide sequence ID" value="XM_025661887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVX3"/>
    <dbReference type="GeneID" id="37165289"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16905">
        <property type="entry name" value="YEATS_Taf14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000254">
        <property type="entry name" value="Ran-specific GTPase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="109"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="YEATS" evidence="5">
        <location>
            <begin position="245"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH53594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="477" mass="53818" checksum="CEF5C7D6B9B9A86F" modified="2022-01-19" version="1">MSDVAETKPDPTISAPEGAEKPEETTTTATEETKTEEKPEESKSVTESAAEAVKDTATKTTDSVFSMFGGGPKKEKQEEPEDAKDEPSGSSKAQKGEDEDEAPESPEVHFEPVIRLTEKVETKTNEELEEQTFKMRAKLFRFDRDSKEWKERGTGDVRLLKHKENQKTRLVMRRDKTLKVCANHYIVPDMKLSPNVGSDRSWVWNATADVSEGEPEAQTLAIRFANSENANLFKDAFEKAQQENEKLLSQQNVRLVTEQHIVNKDSGVEGFPLRSWSIEIYLVNEHGEQVPANVFDKVTYTLHPSFGDRAIQTFKNPPFRISEEGWGEFDMQIGLTAADKEHFVTHDLNFAQPRYESKHVITFKNPKPALLSLLRESGPVPGDENGVKSKRAATGEEGSKKKKRTEKSVDMDKLADGLQRLGEDDLLQVVQMVHDNKAPDSYTKNDVEQGEFHVDLYTLPDTLIKMLWDFTQEKGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX69</accession>
    <name>A0A8G1QX69_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO85DRAFT_490077</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YME2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513450.1">
        <property type="nucleotide sequence ID" value="XM_025663640.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37167042"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12433">
        <property type="entry name" value="RRM_Yme2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000959">
        <property type="entry name" value="Mitochondrial escape protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039627">
        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034260">
        <property type="entry name" value="Yme2_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10443">
        <property type="entry name" value="RNA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="RRM" evidence="20">
        <location>
            <begin position="187"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="18">
        <location>
            <position position="1337"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RAH55528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1394" mass="156565" checksum="ECB044593C2A0CC9" modified="2022-01-19" version="1">MMRIPYRAVVPRATLPHARFSRPSAIPSLTKAFIVNRRTSSHASFIETGHIDVKDDEGLVFVNNIFPSKLQWLLQGPLSGTKTYEEALKRINRPHLAASDPLHIIRRVFPQSLNVDIREVIPRFREGGAFVKYVRKDGVRDTDIVTAVQDHLEHNPIRPWFNPFQQVKVAHVHGRPWIEDLYRIPSQRLRVEFLPGSVDGAATELTTETLYSFFRRYGKLRDIERQPTDSKIAPRYAFVSFTRQKYAVMAKNCMHGFTIPEQEGGGKSGTRIKIKYERKIKLSVIKDWILNHPRIVIPAIAALIAAITVTIFDPIRTFFIEMKIKATLQTEENSVLQWIRNQVNKANIIYFGRQRTDPRRLTAIWEDRQGDIKQLQSWLMENAETFIVIHGPRGTGKRELVLDRALENYKYKVVIDCKQIQDAKGDTAKIARAASQVGYRPVFSWMNSMSSFIDLAAQGMIGTKAGFSETLDAQLSKIWQNTATALKKVALSNRKNDDKEAHLSDEEYLEAHPEKRPVVVIDNFLHNASESSVVYDKITEWAAGLTTGNIAHVVFLTTDVSFSKPLSKALPNSVFRTISLGDCSLDVGRKFVLSHLEHGEKDGANLGQNMEEVGDLGTLDSCIEVLGGRVTDLEFMARRIETGETPRAAVNRIIEQSASEILKMFVFDPDIESKQWSHEQAWHLIKTLAHSQDGTLPYNQVLLSDLFKENGEATLRALEQAELIAISSVNGCPDAVKPGKPVYRAVFKRLTENKTLSSRLDLDIVKQLLSSENKSIGKYEQELQVLGSLPKQPRELSARIQWLLQKVASSQNKISQYERESAILQKYDLLAPGNLVRFVGDVLKTIGWPAIVAILVSICVVTRLITEYQSRSRGISEGRPRPVRTVPYWLPWLGHGPAFAWDHVDLIQKSRKSMKEAVFGIYMGGTKHDIVLAPSLVNSVLAARGTSSTDLINYALEKIFGDRGVVRKLNPVDHHTLNHNIPNLLMREPFLTEGTRTATRLIEREIPNLVTNCRSIVDQMLWERGSQAIVVDGEDPLACEVNFFALIRRFVGHVTTAIFMGEAILEAFPALLEDVFTLDNQFVPLSMGIPRLAHPGVSAAHVARRRLLDSLTEYHQAFVAWDDGIDPGLTFQDLDDISEPIKERIRKCKELGLSARSSAPIHLSLLWAMNGNSPNVVFWHLLRMYASPTLLEEIRKEVAPYVKIVRQESGFAFQEAPKLSIDTDALVKSCPLLKASFYETLRLDSAPLSFRGVTADLTITESAEDAAIAGVAQPRSYELKKGDTVAIPHAVLHTDPKYFANPRDYDPMRFISTDSETGQRKANVHTIKPFGGGVSGCKGRAFAERKLLAFAAAIITMWDVKPAQEGGFTIPEHRPSGAAYLPRKDVRVRITQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX96</accession>
    <name>A0A8G1QX96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_523117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512206.1">
        <property type="nucleotide sequence ID" value="XM_025665319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX96"/>
    <dbReference type="GeneID" id="37168721"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034045941" description="REJ domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH54284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="45248" checksum="90EFE1587A049B6B" modified="2022-01-19" version="1">MKFQHVAPVCLAGCALALPTPVEKRQDLSDLLPFPIPSGLIPTGLSLPSGLSLPSGFPSFSLPTDLSDLGLKRRDVPFSLPSGAALSTDSQGLSQLLPSGLPDLSGLGITLPTGLPFEKRQFGGGGGPEGGSSGGPSFGGGSGGPSFGGGDSSSSSSPFGSMPSLGGGDSSSSDSSSPFGGLPGLGGSGSSSSQSGGSPSPSSGSSSSGGIPDFLNGLGGSSSDSSSSAQPSSGSPLGGLSGIFGGLGGDSSQSSSSPSSSSQPSSSDPFGGLSGIFGGLGGDSSQSSSGPSSSSQPSSSDPFGGLGGDSSQSSSGPSSSSQPSSSDPFGGLSGIFGGLGGGSSSSSAGGDSSSPSQPSGSFPNPFGGSSSSSSSSDSSAPAQPSGDAPQPSAAFPSISLPEPTGSSSSSSSSSSSSDSSDSDSSSSASDSEPSLSLPTPLAFSPGGLNLPAPSSSSAIPTSSAVPTSTAVPTAPSSFKQFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXU3</accession>
    <name>A0A8G1QXU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_401607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513469.1">
        <property type="nucleotide sequence ID" value="XM_025657166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXU3"/>
    <dbReference type="GeneID" id="37160568"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="170"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH55547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="278" mass="30371" checksum="F9D90C23D8D7434F" modified="2022-01-19" version="1">MASQNQSDHQLPSQTIPSTAQFIDQLISHLSTFTIPPVDSNHDHRHQPPARHHHRTPLSTLPPSQMAEVKTIMLTLHCIFPNELLLALDILDRNLVNRFICNDTTNTSSSQTSHPTAHHHSSTTNATTKDIHDYFYVRSASTISPDQSDPFSTSTSTSSYHTKEPDPKGYEVRLKAWNCTCPTFTLNAFRDSGPDGSEEEDSSSTTGHDSLSVTKDNHFPFGGSFTRNSTRSSPPVCKHLLACCLAVRCPGLFGGGEGRSVSIVSAEELAGWCAGWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXU8</accession>
    <name>A0A8G1QXU8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_423225</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514318.1">
        <property type="nucleotide sequence ID" value="XM_025658005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXU8"/>
    <dbReference type="GeneID" id="37161407"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="96"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH56396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="539" mass="61909" checksum="D04B6C83169E24A0" modified="2022-01-19" version="1">MALPRKDQVLSSREIEGLIAAGQSIVIVNQKVLRVDSWIPYHPGGHKTIQHMVGKDATDEFTVFHSEETIKMADRYQIGRVEGRWRNFVPPIQGGQFRPYLDDKAPSDTKQNAPTTSATDQSEPTDNGDGRLSPIRQAATELNTKEAMTFLDSQTKEEISLTLTRYPSLDEATQGDIIKKYQHLHDQIQAEGLYNCNYMAYAKEFARCSLIFTTMLLFLHYGWYCTSAIFLGFFWSQLVFSAHDAAHIAITHNFTIDSLIGMIIAAPIGGLSLGWWKRTHNVHHIVTNAPEHDPDNQHLPFFAVNHRFLGNLFSSYHERLMPYTRAASRLVPYQAYLYYPVLMFGRFNLYVQSWIFLIQGQGPRKGPAWWHRHFEIVGNLLFWLWFGYGLVYRSIPTAWDRFLFVMISHMVTMPLHVQFTLSHFAMSTMDLGPSESFAQRMLRTTMDIDCPEWLDFIHGGLQFQAIHHLFPRVPRHNLRRTQKLVLEFCRDVGIPYALYGFVDGNQKVVGSLAEVSRQAAILAKCQRTIAERGDLLYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXZ7</accession>
    <name>A0A8G1QXZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_470985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin oxidoreductase frp family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512596.1">
        <property type="nucleotide sequence ID" value="XM_025662439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXZ7"/>
    <dbReference type="GeneID" id="37165841"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02146">
        <property type="entry name" value="NfsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016446">
        <property type="entry name" value="Flavin_OxRdtase_Frp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43425">
        <property type="entry name" value="OXYGEN-INSENSITIVE NADPH NITROREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43425:SF2">
        <property type="entry name" value="OXYGEN-INSENSITIVE NADPH NITROREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005426">
        <property type="entry name" value="Frp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="6">
        <location>
            <begin position="38"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH54674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="284" mass="31562" checksum="9473CC9F2798640C" modified="2022-01-19" version="1">MTKTISPLAEARYRDSESSTFPLPTDPSNSLPSTLSTILSHRSCRAFLPFKLPEGTLETLITAAQSGSTSSLLQTWDVIAIQDPEHKSNIATLAADQDFIRQAPLFLVFCPNLRRLKNLSEQYGHQDSPVLDNMNMFIMSTVDSAIAAQNVAIAAESLGLGICFVGALRHNADEVCKLLNLPPLTWGVFGMAVGYPDTENRRSGRRIKPRLPMREVLHMERWDEEGQKDNVASYDKALGTFYEEESKFGRKAWGEFVAGRVASQAQGGWVNIRKVIEKQGFKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY99</accession>
    <name>A0A8G1QY99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_441330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512297.1">
        <property type="nucleotide sequence ID" value="XM_025658803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QY99"/>
    <dbReference type="GeneID" id="37162205"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13204" checksum="3F4449E649CA0FB5" modified="2022-01-19" version="1">MGWFSSDSEQAQAAQEFREFNPEGEVTEEHKAKFSHELIGGAAAYEAMKAYEEHQEKNGKPDSHAQAKEILAGLAGAFVDREFETKGLDAYDHFREKREAAKRHAQEQLEEASAQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYL5</accession>
    <name>A0A8G1QYL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_55900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513935.1">
        <property type="nucleotide sequence ID" value="XM_025665485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYL5"/>
    <dbReference type="GeneID" id="37168887"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="288" mass="32936" checksum="9C00B5D8D5EC87C5" modified="2022-01-19" version="1">MVLSLGLPMCSRRLYTWCFTMFCLGLLALLYIRLLKDDLTLVLSRVEKHPARRKPNALVMAKTSSEDVAWAYALKPHWKPYIYTSDKEPGYRPIPANKAREGMAYLTHIIEHYDYLADVTAFMHASATQWHNDVGDMASSSLLQKLSLDAVNKAGYANLRCEHRPGCPVAVRPFDPAMESNHNVVYRNFTSIYMDMFSVPREQVPTEIGGVCCGQFVLTRDRIRERPRDDYVRIRDWALATDMDNFAAGSVFEMLWHIIFLEQPVSCPDVQQCYCELYAMCPEIDAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYM3</accession>
    <name>A0A8G1QYM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_480917</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511647.1">
        <property type="nucleotide sequence ID" value="XM_025663035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYM3"/>
    <dbReference type="GeneID" id="37166437"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="275" mass="29539" checksum="6010D16D00847146" modified="2022-01-19" version="1">MSLPTVLITGCSAGGIGSALAEAFHERNHHVIATARSVDKMSHLSKFPNMTLLKLDVTSADDIVAAVEAVKSLTGGKLDYLVNNSGLPLTFPALETDIEKAKEVFEVNFWGVVRMVNAFSEMVIAAKGVIANHCSMGGVMTVPWNAFYTSSKAALKSYSEGLRHELAPFGVKVVTIMTGVVGSNLWTRAPELNLEGSRYAPATKEIMDIATGANTGGTMPCSDYARRVVDDLVGGKTGLIWRGKMASIGWFMTSFMPTWVLDMMTKHMSGLDKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYV6</accession>
    <name>A0A8G1QYV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="16">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO85DRAFT_402417</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="16"/>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513314.1">
        <property type="nucleotide sequence ID" value="XM_025657188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYV6"/>
    <dbReference type="GeneID" id="37160590"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="20">
        <location>
            <begin position="472"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="111"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="264"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RAH55392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="831" mass="93255" checksum="062B52085A9101D0" modified="2022-01-19" version="1">MPSHSRSRDRLSPSSELDDADPVYSPSVYQREYYNNNDSLFDSAEEDYARAPRNVYSYETHDEYHDDDDDDDDDAHEDDHDREYDDKFGEPWVPLRAQVEGDAWREGFETAIPKEEDVTQAKEYQYQMSGALGDDGPPPLPSDSLGKGKGKKRLDRETRRQRRKERLAAFFKHKNEGASAGLVSGDALAKLLGSQDGDEDCLSHLGSERADSMSQKNLEGGRQRKLPVLSEEPMMLRPFPAVAPTGQTQGRVVSGAQLEQGGPAIEMRHRGGGGPPTEGLLQKEGDWDGSTKGSSASARPSFWKRYHKTFIFFAILIVMAAIAIPVGIIEARRLHGTNGADSSSNSNLEGISRDSIPAYARGTYLDPFTWYDTTDFNVTFTNATVGGLSIMGLNSTWNDSAQANENVPPLDEKFPYGSQPIRGVNLGGWLSIEPFIVPSLFDTYTSNEGIIDEWTLSKKLGDSAASVIEKHYATFITEQDFTDIRDAGLDHVRIQFSYWAIKTYDGDPYVPKIAWRYLLRAIEYCRKYGLRVNLDPHGIPGSQNGWNHSGRQGTIGWLNGTDGELNRQRSLEMHDQLSQFFAQDRYKNVVTIYGLVNEPLMLSLPVEKVLNWTVEATNLVQKNGIKAWVTAHDGFLNLAKWDKMLKTRPNNMMLDTHQYTVFNTGEIVLNHTRRVELICESWYSMIQQINITSTGWGPTICGEWSQADTDCAQYVNNVGRGTRWEGTFSLTDSTQYCPTASEGTCSCTQANAVPGVYSEGYKTFLQTYAEAQMSAFETAMGWFYWTWATESAAQWSYRTAWKNGYMPKKAYSPAFKCGDAIPSFGNLPEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYX4</accession>
    <name>A0A8G1QYX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_377508</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513091.1">
        <property type="nucleotide sequence ID" value="XM_025656265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYX4"/>
    <dbReference type="GeneID" id="37159667"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH55169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="483" mass="54956" checksum="AE89C8723B4E3DD0" modified="2022-01-19" version="1">MVYRGRPSKSCRECRKRDIKCDKKEDGCSQCSRAGLTCSGYQKPADIVIINETSATAEKVLRKRSLDRPVSAGPLSTNLLPTVLQRAKHLYISQYVQDTPATGIYSYMQVFYPSKSDDYPLLETMINALFMATFSSLQGYPPALYHARNSYGSALSLTRKAIQSRKEALLDRTLFSVLLMSIFERLADVEQRGLSIRNGHLKGAIELMALRGDGQFTDDGGAKMFLHLTELVVLDCLANEADIPLQFLALRQQALEAGADTSSPRWRFLEIMMRYAQLEHTAKSSISAEGVIYQAKALDEDLDRLSKYLPSFFSRRQTPEPPSIPSTKPDIYPDYNTHRCWNNIRVLRIQLMKLIREQYARVLGNSTNDAWAMAELHESNRRVHSLATDICLSIPDTGANIRLPYEVSNIQSATLLFHLYVAKDALAKPAQSRLYIYERLQFVEEKQSPSQRKILDYLLHDGYQMPRNTWKIWLSIGREDFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZI5</accession>
    <name>A0A8G1QZI5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_496346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515203.1">
        <property type="nucleotide sequence ID" value="XM_025663954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZI5"/>
    <dbReference type="GeneID" id="37167356"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="722" mass="80036" checksum="65588F94066CAEFF" modified="2022-01-19" version="1">MQKDILTSPLEAGEEGEEAKGENEDSNTRSDAINLIRARTISRSSTPKVPQEGLAGDNQRAVSIPRIVVMEPPGEARARRNKKKKDKYNKKKKLLLGDSGSETSGSQGSELNSKPIADSNTLSDASSHSKDIEDLSHLGRMSAKGLYSSVVASKEKPTPDNNVSQGCTVDSDKKRTLIESLSKLDIKGKQRIQRVNAVTGNDTLGGINTQRGPQPVDRARRTVITPSYATVLSGKRALLNNPSDSLQATMAAFSKVSDESSPRQDSNCEARSSNALLSPIPEFSSEAATPGNLNSHKPLSQTDPNTAGSNSLDNLTSTPVSTASTGWSNTTLQTSPQTTEPSSEPSSSKAASHRHATSLHHAHPLPPTPPSSTHSHSLSTPNEAITNAQGTLSAQKPEGFFWQLDSHGFPCAKAHCEKRCNLWDGATVICPRCGPYSEVRYCSRDHLLEDIKPHWLYCGQMVFQHPCRETSIPRRVRVGPPMIPCVHHYDMPERHRQAVHFNMNFREGDYFIFTDWLDFVTAGLPGDKTAIRCSNRVMYVVKFDDPAEKDRFRRVLAACLFMTIELPDLTDYLYRLIRDKLRLSNAPNHIEPSLRYQFLQEFNVTIQECITGARHACETDWDGRNRRNCHDPVCRSEYRRLLGSIGGRGYSRVIEALESTYWILRAARTTHPTVGDAMKRMRGEGYEEVADEDRRVFRRGDGWDGAGTGDMEIEGFNEGDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R085</accession>
    <name>A0A8G1R085_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_33780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515055.1">
        <property type="nucleotide sequence ID" value="XM_025655451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R085"/>
    <dbReference type="GeneID" id="37158853"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="94" mass="10532" checksum="E99A96EE4F99AE52" modified="2022-01-19" version="1">MGTRPLNSETIGGRASPDCRVLDCQVAPTCFALSFDHFMTIVLSMVTSPILWGLEGIGWDGSLISAACMRLRHDACTFELEKWDRRSQAENRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0A5</accession>
    <name>A0A8G1R0A5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_470689</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513332.1">
        <property type="nucleotide sequence ID" value="XM_025662419.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37165821"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF404">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="877"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="927"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="997"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1026"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1102"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="273"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="607"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="903"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1207"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="821"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="821"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="842"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH55410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1443" mass="159920" checksum="E7ACE6B0DB92AC65" modified="2022-01-19" version="1">MACPPNSDNVFGPRVNPECRPFDFTLLFEDAFFGLLPAALFLVLTPQRLYMLRTSPVKLDSFRLILVKLTLLAVLCILHILYTALRVEDPELHTSVGLASGIVNIIATGGAIMLSYLEDQRSVKPSDLLVIYYSVQLLLVLPQLRSLWQISTASEPCRALWTTIFVFNIAVLIAESMHKNRFLRPLYQKTKGEGILGFWGQSFFIWVLPVLQTGYSKVLGTDDIPEMDADQQTQLTGEELEKAWKINSGKHRLLCSTFSAYRNTFLSAIGPRLCLSAFNFCQPFLITTTIAYIQNDGSDPDRKRRGQAIVGAYVLVYLGWVLSTAVYWRQTNRFNTKVRSGLISMVYTQTSRLKASDIKDSAAITLMGTDVERIVQSQKTIHETWASVLEVGIAIWLLERQLLVACVVPAVIAIGSVLAIGPISARSGQAQKEWIERVQTRVAATSTMLRDIKSIKMLGLSQVLLSTTSELRKIELKISERFRKLLIWEIVISNVPTEFAPFATFAVYTIIAVVKHDKTLLSSQAFTSLSLISLVTSPLITFVQAVPSVRQAMSCYLRIEEYCEKEPAGLVTHTASSPVLSLTDNDRDVELRSFQPKSEYSATPVSFERASVGWSKAGENKLHDITLRVGSGVTMLIGPVGSGKSTLLCSLLGETVIKSGDVRVEDHQMAYCSQAPFIINDTVRQNITFGSPFDPKWYEFAIWACGLKEDLSDMPGGDLYRAGTNGLSLSGGQKQRVALCRAIYSRRRLVVLDDVFSGLDSNNIRVISTRLFGPNGYFRRPGMTVLLATHTEHLFQYADDIVVLEEGRIVQTGSFENVMQLSKPASTESPVSTVGTADHAASATQEGDELSNTAANPSPPDSPSPLRREGTWSVYKYYFRSAGFIPFATCLAFIVVEAVSGDFTTLWIQWWVEANERSPNKDAGMYLGVYAALFVIQLVGNVGGLWLLIINIINNTALNLHTDLLTATLSAPLRFFQDTEIGALTNRFSQDMELIDMMLPLVASMYLTGFASCVVKLVILCIVSKYLAVAVPALLVSLVILQRYYLRTSRQVRLLDLEAKAPLYTHFTEAVHGVTTLRAFGMNPWFQEKLHMLLDKSQRPFYMLYCIQQWLTLVMGLIVAALAVIIVAMTTSLADQYNGAAVGVALSLILTFNSTISSTLRSWTSLETTIGAVSRVQRFVQDTPREANHGLMRSVVPGVSGHSQFTIAFDNVTAGYSQASPPVLKNLSLTIRHGEKVAICGASGSGKSSIIMSLLRMSEIQSGKISIGGCDISELERQAIHSAINVIPQDPFLLPGTVRFNLDPFGMATDERITSGLQKVDLWRRISTDGGLDMDMSSISTWSVGERQLLALARALVVPRPILILDEATSSVDRETEAFMQEIIEQNFRHQTVIAVIHRFAHIDRFDRVAFLQDGEMLECDAPQALLGRDCNFRELYRAWERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0Z7</accession>
    <name>A0A8G1R0Z7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_496303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515165.1">
        <property type="nucleotide sequence ID" value="XM_025663952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0Z7"/>
    <dbReference type="GeneID" id="37167354"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="135" mass="15617" checksum="502D1E16AA8C8EAA" modified="2022-01-19" version="1">MKHHNHYHTPYYTHLIQTNKSNSAGDWHRWLVAAATRDDMITFFKGLIKYSKTSGAKITDVKPIHLAWWTFDSPNGYNIRELVKQIYQLNPSWYGNVEELNDSRGKVTVTLLDDAGGRSWPVLPCQDVELGEHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1F4</accession>
    <name>A0A8G1R1F4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF895 domain membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_519700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515715.1">
        <property type="nucleotide sequence ID" value="XM_025665072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1F4"/>
    <dbReference type="GeneID" id="37168474"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF19">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="110"/>
            <end position="130"/>
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    </feature>
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        <location>
            <begin position="151"/>
            <end position="170"/>
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    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="470" mass="52326" checksum="708321C5C3B559F8" modified="2022-01-19" version="1">MADAENGSGGKVPLKRVWYRTSLFNACVIGAVGFLAPGLWNAMNSLGAGGEEKPFLVNAANALVFGLMGIFCIFGAPIANRIGLKWALLLGAAGYPVYAAGLYTNNRFGNVWLVLVGAVACGISAGLFWASEGAIAIGYPEPSKRARYLNIWVWWRTLGPIIGNSIVLALNIKNKDKGSVGYSTYIVFIVLQCLAVPVALLLTPPNKVQRADGSPVILRVEDSWKAEFQALWKTCKNRTVILLLPVFWAVYFNEYSSNFETYYFGVRARALIAFLSDWVTILASQIISHWLDWKRVDAKKRLTYGWYWVIIVHVTAWILGWVVQEQYTSAHKKNPDLGTMDYTSPGFTKGAFVLFMWTFAQQTGQNWLYYLVGSMTDNIAELTRLTGVLRGQESFGEAISYGLNTRDWYGGRVPMAVNTILLGLCVIPTWIVVKNHDMESTDERELEVDRRPVVDEKGVVDLEVKETGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1L5</accession>
    <name>A0A8G1R1L5_9EURO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_438810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_025658689.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A8G1R1L5"/>
    <dbReference type="GeneID" id="37162091"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="415" mass="46890" checksum="ED0D8096A6360641" modified="2022-01-19" version="1">MSNPHLRLDTPQSHTIFIRPGIEPYTSSLPGSVRLSRKPSMDMDMTDSARNITISLVRSVKFDGNSSPRTNLKGRWRSTLRYRQSTTKQFIAPGYEETVLNCILWSALNKLESCRDTDTEDGVVYYFNIPVPNCLPPTMKTELGTVDYYLKATIDLESGRKLSVSKTLDILYRLIQPTSFPSNYSRRFTASPLMIQTTISQQRPKDATTKAMFSVELAIRNLLTPGARDGEMKYIAISAIKWSVDEVAMRRNIAHCEMQAFANTTTTSKRSLIEGKLEPRCPKVILNRSDQSCLRDGCLRVDFEIRIPESANAADEICESYCGGDDPRNIFPLADLPGIAINHELKVELITREDTFSGRTNKKLDRKPIAKLYGAIFPLRIHKLANDVDAMETYCLDEPPAFDVTQQMLPPKYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2F8</accession>
    <name>A0A8G1R2F8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA binding protein Jsn1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_79278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
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    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025665667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2F8"/>
    <dbReference type="GeneID" id="37169069"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RNA binding protein Jsn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000339">
        <property type="entry name" value="RNA binding protein Jsn1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="482"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="9">
        <location>
            <begin position="607"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="6">
        <location>
            <begin position="682"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="6">
        <location>
            <begin position="718"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="6">
        <location>
            <begin position="755"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="560"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="972"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1181"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="976"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="999"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1181"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1194"/>
            <end position="1204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH55660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1204" mass="128854" checksum="F5605F8E0D738EB7" modified="2022-01-19" version="1">MLPVSRPDGHMNLNYIPTTQPMSGTSTGRSSPSDLSGSAAIKSPFGPSNGLNGAAGAIGGARLGAGSPSHELGARLYSKRAREIQAEEGVSPSIWGPPTSGHSTPLRENIPESPSQEGFPDLVPTSSGSINSPGRRARAGTVPSRFSPVGALNEVNLQQPYMPQTSRPTPSTSPFRPSGVSGIDTGTKTATAPGGSSAGSLSRLRAGSMPQRANFLGSSGPFGPSLFSTSWATGRERATTLTSIRSSEGPASPSQSSFSRDGLADTDVKTLDYLGLAETPQQARATLVRPDVNMLLQQQQQQQQQQQQQQQQSSLPPLLAELAMMKNNSRIRSYSVNAKEKYADDEDLEYESRYSQLPSGTVTPSAAATAAQLAATQAQIHQHNLAVQAFANHASASRPRARTAGILEAPPQRSSIRNYLATPSRLENSFSAADLNIAEGGEYDELSEAVQLMHLGGSGAPNVGMRQTGDLADENNQDGPTRALWIGSIPVSTTVTSLEAIFSLYGKIESTRVLTHKNCGFVNYERIESAIQAKSLLNGKEIFPGAGPVRIGYAKVPGTSASGTPGVNGAQSSPTPDPSMNGPDGIVRPESGTSIPHIPSLPELQPEMAQIVTEFGATEDDAHNISASIHRAIAFDAFEDEIPPIAEPSQTRMFDAPRLRDIRKRIDNGACSVQEIEETAVAMLPEIAELASDYLGNTVVQKLFEFCSESTKEQMLGPIAPHLAEIGVHKNGTWAAQKIIDVAKTPNQMQMIVDALRPYTVPLFLDQYGNYVLQCCLRFGAPFNDFIFETMLSRMWEIAQGRFGARAMRACLESHHASKDQQRMLASAIALHSVQLATNANGALLLTWFLDTCTFPRRRTVLAPRLVPHLVHLCTHKVAYLTVLKVINQRNEPDAREIVLKALFFSPGDEVLEKILSDQTSGATLIFKVLTTPFFDESMRAEVVKNVSKVLTKLKATPSQGYKRLMDEVGLSSRGGARDNHHGRDHVSNSDKQQHRPTSRQAASNYGSQQSMERQYGAQFPTMLGPGLDATRPVASEQQPNPAPFDPYSINGMNSIGSAGGLSPLNGVGGVGVNGTGFGQEPLAPLTQQQLQYQAYLAAQSRGLSPSGLYPSLGNSSFGYPAGAPSADSLRALQTPGVPLAGGPGQMNSNPMMNQPTFAPQQFSPVTNSAQMYQYPTQFYSQAQPAQTQSAGGRRGRVSHPQHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2K4</accession>
    <name>A0A8G1R2K4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_397590</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for methylating the 5'-cap structure of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="3"/>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515418.1">
        <property type="nucleotide sequence ID" value="XM_025657027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2K4"/>
    <dbReference type="GeneID" id="37160429"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000231">
        <property type="entry name" value="mRNA cap guanine-N7 methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="16">
        <location>
            <begin position="283"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH57496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="641" mass="71968" checksum="CBBC746B6F2C5DE1" modified="2022-01-19" version="1">MASEEEQQRTGQRPSISMYDPARDRWEEQPVVAAEPAPVSASIEATPSQTDEAKPVHDPTVTSTSEPLPLPQTTTTESSQQPEQQQQQQQKQPPIPTPPSSQSRRKHKINKMGDYSRSGSADVYAEQSSPAADSHKRKLEDETSEQQPPADQVNDRPISKRKRLEERHQKLRKRGQAPPSAYSRRDGDETAARAAPQPRSPSPPLPPRSPSPEVQARQRKRPGGGARRGLVDPQTLRRRQEERERALEEDAMRNSQSRGVTDIVRQHYNAVPQRGREWRKTESKIKGLRSFNNWVKSTLIQKFSPDEEFVARAIGTKDWADGTGPPPMEEKRLLVIDLGCGKGGDLGKWQLAPQPVDLYVGLDPAEVSIIQARERYAGMRSGRGPRGGGGRRGGPPLFHGEFRSKDCFGEWLGDVDIVQQVGVDPNVGPGGSMMASRWGGGGFDVVASMFAIHYAFESEEKARQMLRNVAGCLKKGGRFIGVCPNSDIISARVAEFNAKRKDREAAKQDAEPEDGEVEEEAKAEWGNSIYRVKFPGDTPEDGIFRPPFGWKYSYFMEEAVGEIPEYVVPWEAFRALTEEYNLELQYRKPFMEVWRDEKDDPELGPLSERMGVRDRTTGELTMTPEEQEAVSFYHAFCFYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2L9</accession>
    <name>A0A8G1R2L9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_477119</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516345.1">
        <property type="nucleotide sequence ID" value="XM_025662818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2L9"/>
    <dbReference type="GeneID" id="37166220"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07105">
        <property type="entry name" value="ALDH_SaliADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="34"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH58423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="478" mass="51207" checksum="568573F4CD89807E" modified="2022-01-19" version="1">MVTTTAIPLIIHGKDILLSNNDRKHPITSKSAPHLKSFQGATSDLAVQAVESCASAFPSWSQTPPEERRRLLLNLARLLREKSSTIQTLIKDEIHCTPLWSQLNVEIAAGIVEETASVITDAISGTIPSSQGNTYALVMKKPLGVVLGIAPWNAPVILGLRSVIPVVAAGNTAILKGSELSPQTHYFLAALFREAGFPPGVVNFVLHRPQDAAEIYECMIQHPAVKKCNFTGSTQVGRVIASKAAMALKPVLLELGGKNPVVVLEDADLDQAADEIIGAGYLNNGQICMSTDLVYVVQSVAKELTKKILERLHSEDRPHKVISAAGRARLTQLVEDARSKGAGIHQARNPLAEDPLAFPATVIEGVTEEMEFYTIESFGPVFGIIAVESAEQGLQMVKRSAYGLSSAVFTRDHFKALGMSADIAVGAVHVNGGTVHDEPTLPHGGVGDSGYGRFGGKWGLNEFLQTQTVILNRVRASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2M8</accession>
    <name>A0A8G1R2M8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_512539</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516360.1">
        <property type="nucleotide sequence ID" value="XM_025664660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2M8"/>
    <dbReference type="GeneID" id="37168062"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="28"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH58438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="543" mass="60481" checksum="125842190358706B" modified="2022-01-19" version="1">MAGGTSIWASQEARTDPRQIFNGRLAYLLITLAWAGWFYGFDTGNIGGILTLPSFEHAFGLDKLTTAELDSRKGTIAAMLAAGGSAGSLCAAPTADFLGRKWSVFLWGFVFVIGGVMQMIANYKVLIAGRFIGGMGVGASSMLSPQFLAENSPKSVRGSATAMYNLMILAGLMVAFWINYGVSLWSFPGVEQDNTQWRTAMGIQLIPGVLMCLMIPFVPETPRYLINHAKEEQGLKNLCRLRKLPADHPYIQTEYQEIVAQVRFEQECHQGHSYWVVLQDIIFIKSNARRFFLAVMLFLFHKFTGTDSLNYYAPEIFELIGVNGTSNSLLTTGVYGVVKFVVTIFYVTYLVDRVGRRRPLLVGAVLQATAMLYLALYLRFAGTNTSTIGGTPAGGIVGIVWIYIYAFGWSFGHSVACYIVAAEIFPTRIRSVCMGFCFFVNWIVDYGITRATPDMITNMGWGVFLLYAMLTYSGVVFIYFCLPELKGRSIESIDDLFQRPLWTMWRHAYPTEEEKVRQGIPQLAKGQANDDGDKQSVDHVERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2R8</accession>
    <name>A0A8G1R2R8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_300683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515369.1">
        <property type="nucleotide sequence ID" value="XM_025655343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2R8"/>
    <dbReference type="GeneID" id="37158745"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF227">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH57447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="539" mass="60535" checksum="A47CF6F6CF940BB6" modified="2022-01-19" version="1">MAGIPWNTIHVGIAVYSYFRSTFRDFLLLSAVTLVLRILYRLVLYPVYFTPIKHIPTPPGRAWFTGNNGSFVLVNPYDRMRRWNQEIPNDGLIRFYLGGNLERTIATTPKALSEILVQKVYDFEKPKIVRRSLGRITGEHGVLLVEGAEHKQQRKLLMPAFSYRHIKNLYPIFWSKGIEMVKLIEADLQQRANPTDNVIRVASWSSRATLDIIGLAGMNRDFDSLQNPTNKLAAAYHKLNSVPPTHLEKGLFVIGLLLNVPHLVHKLPFKRNRYIRESATYIRNVAQEMIHDARQSIEGEKAHQTTDAVDILSVAIESGGFTDEELIDQMMTFLAAGHETTSGALQWCVYALSKYPDIQTRLREEIRANLPSISVENPESISAATLDSLPYLHAVCQEVFRFHPSVPNTVRIANKDTTIGGQRIPKDTVIQIVPALTNHDKSLWGPDADQFNPDRWLGPGKANTGGATSNYAFLTFIHGPRSCIGQGFAKAELACLLATFVGKFQFELEDPDKELILREAATVTPKDGVLVKVTPLEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3E7</accession>
    <name>A0A8G1R3E7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_305526</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515461.1">
        <property type="nucleotide sequence ID" value="XM_025655371.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37158773"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002416">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="582"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="756"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1187"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1296"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1324"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1356"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1449"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="146"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="840"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="806"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="825"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH57539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1490" mass="167544" checksum="A760BACECD60AC3D" modified="2022-01-19" version="1">MDSGRSPPSEPRFVPDEDEKKAPLDSSSDSSSSASRSSGLSRKQSAIPVEHQVSNENVIRQESSLQRQLTQQDIARALSQRRSTGAAGADDTDQIARLVSRMFGQERKANSEEEKTRHLGVVWKDLTVRGVGLGAALQPTNTDILLGLPRLIKGLLTGGRKSAPLRTILDDFNGCVRPGEMLLVLGRPGSGCSTFLKVIGNQRSGYKSVEGDVRYGGADAETMAKNYRSEVLYNPEDDLHYPTLTVRDTLMFALKSRTPDKASRLPGESRKHYQETFLSTIAKLFWIEHALGTKVGNELIRGVSGGEKKRVSIGEALITKASTQCWDNSTKGLDASTALEYVESLRSSTDMAHASTLVALYQASENLYNLFDKVMLIEEGKCAYYGRTENAKAYFERLGFVCPPRWTTPDFLTSVSDPYARRIKEGWEDRVPRSGEDFQRAYRKSDICKEAKADIESFEKEIESEQQACEQAREKKKKQNYTVSFYKQVVILTQRQFLVMYGDKQTLIGKWVMLTFQALIIGSLFYDLPQTSAGVFTRGGVMFYVLLFNSLLAMAELTALYGSRPVILKHKSFSFYRPAAYALAQVVVDVPIVFVQITIFELIVYFMSNLSRTASQFFINFLFVFILTMTMYSFFRTIGALSASLDVATRVTGVSVQALIVYTGYLIPPWKMHPWLKWLIWINPLQYAFEAIMSNEFYDLNLQCVSPSIFPDGPSAQPGNQVCAIQGSTPNQLVVQGSNYIQTAFTYTRSHLWRNFGIVIAWFILFVCLTMVGMELQKPNKGGSTVTVFKKGEAPEAVQEAVKNKELPGDVETGSDGTGTTNGFQEKDTDGSSDEVHGIARSTSIFTWQGVNYTIPYKDGHRKLLQDVQGYVKPGCLTALMGASGAGKTTLLNTLAQRINFGVVTGTFLVDGKPLPKSFQRATGFAEQMDIHEPTATVRESLQFSALLRQPKEVPIKEKYEYCEKIIDLLEMRPIAGAIVGEGGAGLNAEQRKRLTIAVELASKPQLLLFLDEPTSGLDSLAAYNIVRFLRRLADAGQAILCTIHQPSAVLFEQFDELLLLQSGGRVVYNDELGTDSKKLIEYFEQNGARKCSPHENPAEYMLDVIGAGNPDYKGQDWGDVWARSTQHSQLSEQIEKIIQERRNKEIEGGKDDNREYAMPIWVQILTVSKRSFVAYWRTPQYALGKFLLHVFTGLFNTFTFWHLGNSYIDMQSRMFSIFMTLTIAPPLIQQLQPRFLHFRNLYQSREAGSKIYSWTAFVTSAILPELPYSVVAGSIYFNCWYWGVWFPRDSFTSGFVWMFLMLFELFYVGLGQFIAAFSPNPLFASLLVPTFFTFVLSFCGVVVPYSSLNVFWRSWMYWLTPFHYLLEGFLSVVVHGVPVRCVPREESEFSPPSGMTCQEYAGSYASQIGGYVQDAGNGLCAFCQYSVGDAFARNFNVYYSHKWRNYGIFWAYVIFNFMAVFFFSWLYLHGARNIKRSISARKSKKAAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3H0</accession>
    <name>A0A8G1R3H0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_448780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516686.1">
        <property type="nucleotide sequence ID" value="XM_025660015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3H0"/>
    <dbReference type="GeneID" id="37163417"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="230"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="736" mass="83667" checksum="0F6F127789D1767D" modified="2022-01-19" version="1">MRLINARTLGLEEFLGQNIPKYAILSHTWGEDEVSFQDMQTPTATKKLGYAKIKHSCERALQDSLDYVWVDTCCIDKTSSAELSEAINSMMAWYAQSKICYAHLADVPPITDQGLDKAAFSRSRWFTRGWTLQELIAPAELVFLAQDWSDIYEREILAGLISDITGVHHSFLDWRLDNSMLGFRLKSTSIAERMSWASNRETTRIEDMAYSLLGILQVNMPLLYGEGSAAFRRLQEEIIKYSDDQSLFAWSFGGPKHDLSHKRPWSISQSLLEKIISFFKDYETPPESSGAMQIDISDISEILAESPAAFRGCGNIVPCDVKKPTPPFSMTNKGLSIELPLLELSDGCFALLQCQTRTDPTRLIALPLLRIDDTYCRSKRGNYVANHAAWLRWPRAQLYFFPDEDSTIAGIMNCPCYSVVIKSLPPNLRIAKVLPSSPYWQPNSTVIFKKARDVFDSDVKDVFVQFQDIADSGQTFILAVRMQQTLSWRPNAKWQDTLTPYLFLPPSDNINLTLKDLQNVLRQESVKAKPPVPYSVEITTKTLSRSGLYMVDIIPKRPAKKEGNKEIHNLRFWTGLLRRTLIRDSLVERVYEDWLDYLCDRGLKSFRLLALLPLFFAFPFDLILRVVVSLTAPVLSHIAFYKKCLTAATYENRLTSVVLEMSRTAMAHKFSLAAVVSGSGLLLSNTPAMRKISIWVLKYSRSRGVFKILLLYIICKCIPPRTLLSLAGEEEIYHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4X7</accession>
    <name>A0A8G1R4X7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenol 2-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_457052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518083.1">
        <property type="nucleotide sequence ID" value="XM_025661486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4X7"/>
    <dbReference type="GeneID" id="37164888"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006144">
        <property type="entry name" value="PRK08294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF10">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="397"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH60161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="602" mass="66744" checksum="ADEA2F4684924CD5" modified="2022-01-19" version="1">MTQKVDVLICGSGSAGLCAAAWLARYGITCKVLERRDGPMTMGQADGVQCRTVEIFESFGIGEELLRESYHVVEVVFWADDSGSGVIRRTGKTADTQPGLSHQPHVILNQARINGLLIDLMKKHNNQEIDYGYTVKDVRVDETQLSAGPEAYPVKVTAEKDGKVESFEAKYALACDGAHSTVRKALGYNMIGDSTDAVWGVMDMVPRTDFPDIRKKSSIRSKAGNLLIIPREGDSYNLTRFYIELPTGTKAKDVRLEDLQNAAKRIFSPYQIEFVETVWWSAYAIGQRHADFFHKGYRVFLAGDACHTHSPKAGQGMNVSLQDGYNMGWKLASVLKGLAHPSLLETYVLERQKVAIDLINFDRYFAKLFSSQGSATPQEFQEGFIKSGKYTAGLTAKYDESPITSDTGVSTELATNVVVGMRLPSAQVVRFCDAKPLQLAASLKSDGRWRVMAFVGDLSVSQNMAALQAVGEYLGSDDSPLQKFRSTSGEPDSLIEPILVAHGKRHGVELEQIPQSFYPFTGKNHIRDLHKIFFDDESYNRGHGHLYEHLGISPDKGAIVIVRPDQYVSAVFSLDDYRRIGQFFEGFMIPQERSESLTGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4Z7</accession>
    <name>A0A8G1R4Z7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_458907</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516693.1">
        <property type="nucleotide sequence ID" value="XM_025661616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4Z7"/>
    <dbReference type="GeneID" id="37165018"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH58771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="284" mass="31991" checksum="FAFC44823B92A00A" modified="2022-01-19" version="1">MSNDDSTWTYYHYDPSLPAALIFTILFGISSVVHTIQMLRTRTWCFIPYVIGGYFECVGYIGRAQGHYETPNWTLGPYVLQSLLILVAPALFAASIYMVLGRLILITKHPEYAIVKPRWLTRFFVSGDVISFLVQAAGAGLMVTGANGMRTGEDVVIAGLFIQIAFFGLFIVTATVLLWRMQRNQSAARLTIPGLPWRKNLLVMYAACLLIMARLVFRVIEYIQGNNGYLLRHEAFLYVFDGALMFMQMLLYNMCHPSELISTGKTAILPNGQSSSVRLRPFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R696</accession>
    <name>A0A8G1R696_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YjgF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_418101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516946.1">
        <property type="nucleotide sequence ID" value="XM_025657800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R696"/>
    <dbReference type="GeneID" id="37161202"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000004">
        <property type="entry name" value="Translation initiation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF12">
        <property type="entry name" value="TRANSLATION INITIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="116" mass="12638" checksum="ECC1F5A02B07CBF6" modified="2022-01-19" version="1">MSRQLISSEKFPPKPHNCPAVKVPGLVFCAGQTATGEIKQATRTVLQNLKEVLELSGSSLEQVVKYNVYLADMKDFAAMNKVYIDFLPKPMPSRSCLQAVPPGDGTVIEIECIAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6A6</accession>
    <name>A0A8G1R6A6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_275821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516407.1">
        <property type="nucleotide sequence ID" value="XM_025655143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6A6"/>
    <dbReference type="GeneID" id="37158545"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF1">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="123"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="222" mass="24537" checksum="0BF3BBE5D356FDB5" modified="2022-01-19" version="1">MVDRQDHSSAPDKAIAAATGREILTPPAACHTAQRPHRDDDDARSTDNDLDALELRNIATQDDDEAGFSTESISSGEYRVRTHRTVSRTTHSNREDTSKGLTGRVRRFWTRNVVLTVPQKSNRDHFALERTFLAYIRTSVMVAMQGVLIAQLFRLQHLASPDPALGFYEVGVPLAVSCYSVAILIAAMGAYRFWKQQNVVALGTVYAGGWELNCIGVLIGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6D4</accession>
    <name>A0A8G1R6D4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="4">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_358160</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="4"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517428.1">
        <property type="nucleotide sequence ID" value="XM_025655498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6D4"/>
    <dbReference type="GeneID" id="37158900"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF58">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE XGEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034633612" description="endo-1,3(4)-beta-glucanase" evidence="16">
        <location>
            <begin position="25"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="17">
        <location>
            <begin position="31"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH59506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="320" mass="34433" checksum="AD2295A6B91E4D5B" modified="2022-01-19" version="1" fragment="single">MPTSSLLWSVGSLALSSMILPAAASGYQLVETWKGEDFLTAFDFYTGADPTNGFVTYANQSYAESKGLVKVNSNGSFYMGVDHTTKLSTNGPGRESVRIGSNKYYDEGLFIIDLEHMPGSVCGTWPAFWSTGKDWPTDGEIDIIEGVNKNEANEIVLHTSGTCQVSSQKMTGTLSSTECGEDSGTTGCVVEGTQGSSGTPFNENGGGVYAMQWTDEFLKFWFFPRGSIPTSITKGDPDVAAFGTPMAHMQGSCSIAEHFKAQQFIFDTTFCGDWAGGVYSTSGCPVSDSSSSFKSCVAYVAENPAAFAESYWEINYIKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6F7</accession>
    <name>A0A8G1R6F7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras-related protein rab-6A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_276569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516482.1">
        <property type="nucleotide sequence ID" value="XM_025655151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6F7"/>
    <dbReference type="GeneID" id="37158553"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000229">
        <property type="entry name" value="Probable Ras-related protein Rab-6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="209" mass="23382" checksum="F429A19D917CAAC3" modified="2022-01-19" version="1">MASTSGVGSYSNPLKKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDISNAKSFQNTRKWIDDVRGERGNDVIIVLVGNKTDLNDKREVTTAQGEEEAKKNGLMFIETSAKVGHNVKQLFRRIAQALPGMEGEANRGDNQMIDVNITPKETTTNDGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6L3</accession>
    <name>A0A8G1R6L3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_447014</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518381.1">
        <property type="nucleotide sequence ID" value="XM_025659627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6L3"/>
    <dbReference type="GeneID" id="37163029"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000069">
        <property type="entry name" value="Seryl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="186"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="322"/>
            <end position="324"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="338"/>
            <end position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="431"/>
            <end position="434"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="8">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH60459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="509" mass="56076" checksum="B25953C1C685C9B6" modified="2022-01-19" version="1">MAPPRPPYVCINCRLFGRRPFSSSTRRADLVRPATAPKPTPDIKHIRQNPELYSKNCVDRNYPAHAEYPLKIQQLTDEARRLDQDLKTPRARIKELEKAIAKVASAANNDTSSTELASLRAEATRLKDDSNNMATRKTTCTDEIHRLALSLPNLSSTHTPIGADPTLINYINFDPESPPTWVTHPDPKRSHVTIGTNLGLLDFTSSAITTGWGWYFLTNEGALLEQALVQYALSVARRHGWKAVSPPSLVYSYIAEACGFQPRDQHNEQQIWSIEQNEKDKSKPQRSLAGTAEIPLAAMHAGRDIPATQLPLRLVGPSRCYRAEAGSRGVDTKGLYRVHEFTKVEMFAWADNLPDSTATTTTTKKPTTTSDDLFAELLSIQTEILTALNLPARVLEMPTSDLGASASRKRDIEVLFPSRLRAGDLESGWGEVTSASICTDYQSRRLGTRVRGGAAKESRFPHTVNGTAMAVPRVLAAILENGWDAERGVVVVPEVLRGFMGGMEVIGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R742</accession>
    <name>A0A8G1R742_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_447748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517803.1">
        <property type="nucleotide sequence ID" value="XM_025659781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R742"/>
    <dbReference type="GeneID" id="37163183"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="191" mass="21690" checksum="490DA637BF399CA3" modified="2022-01-19" version="1">MALHSQTRHPARGLFERNVTTGLRGHYLSVLENLGSMFPSLCFGPNICPHNVLIVRKISQYDGFGTVTAILLNRRRQRKIHTAGGRDRSADDVRSRLVIPKFLHISIGDSKQARLIKPTTDSTQFADSRNVAWLPERSFCILLSIVWFIKNPCFFCFRSTTGNQDALRVYARSQPARIMKLIEVVLSIHPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7L9</accession>
    <name>A0A8G1R7L9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_255787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517904.1">
        <property type="nucleotide sequence ID" value="XM_025654978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7L9"/>
    <dbReference type="GeneID" id="37158380"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="92" mass="10698" checksum="E27EB81DEAE1AFF0" modified="2022-01-19" version="1">MVPKLSFVVVFFFLLFYISLYTFRGWFTPTSILGCKLVVVSYVLVSMAHDTLQYPHHLFFFTLKQDNKRVALILRTLFLFPSFLPSLSIGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7Q0</accession>
    <name>A0A8G1R7Q0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_475044</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518765.1">
        <property type="nucleotide sequence ID" value="XM_025662694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7Q0"/>
    <dbReference type="GeneID" id="37166096"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH60843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="291" mass="32291" checksum="D85B3F2905F78550" modified="2022-01-19" version="1">MSSVTSPHRLSARKSGHRSAAAPASIRNTSSAARPASQPLRRSLPSQQTSRASPAPPRQPSTGHVSSQLASAWPFNPQETELIRAGYRPAFKPQPVAEADEQSSNNSNKNNNKKGKTNKKNNMAEPRARAARHKGQMNFASELRLLLLAYGDPRPHPSYPPEPLPETIRVLDEIVTDFVLEMCHGAAQYASYSRRQKIKVDDFRFALRRDPNKLGRVQELLRMERELKEARKAFDQNDDQVGNLKDAGKKGLEELGESVDGKKSKGKGKRNARRDSDATEDTAPKKRKVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7X0</accession>
    <name>A0A8G1R7X0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_445136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519643.1">
        <property type="nucleotide sequence ID" value="XM_025659183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7X0"/>
    <dbReference type="GeneID" id="37162585"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="124"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="267" mass="29815" checksum="2DF5B85EF12B02D9" modified="2022-01-19" version="1">MPQKEYTLHPAHPSHSPTLAETMILSRLTDPHWAFLFTPSTTPASIISSTASRLPHTLSTARDVRRHEVVLTTTTEESTPGTGTENAEHTTLEGKERVIGYARWTLPPSLSNRDDVWLSAQVPAPSSQEKEQQFKKMYDLGSDEKGRVKGMKSDGLLEFRGTPLEEVEERVLRDVVGGEEVLTLEYLTTHPDYWRQGVGSMLVQSGLRVADQYGIKTYVMSEPAGLKVYLNHGFRVVDEITVEYAQFGGTEPTTHYFLVREAVVGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R855</accession>
    <name>A0A8G1R855_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glycosyltransferase family 71 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_448534</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516417.1">
        <property type="nucleotide sequence ID" value="XM_025659957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R855"/>
    <dbReference type="GeneID" id="37163359"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH58495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="57632" checksum="AC3183BE6D1677D6" modified="2022-01-19" version="1">MTWDESRKLLSHNMSQFAAIRSQRGFRIVFAAIAVIFALSIFMLLPPASTTTKVLGFGQGQKPTTQSSSAEAITIDTSLITDLSQYFADYPIQKPFKEKFGELGRRNRVLRDWLIQAETSQDSTTKSILRNAIEEVAIAQYPFLQPPKQTQSHQSRSSRHPVQDLRASFEPDSAGIVIPTSDHTLRYAAHLIASLRSVLNSTLPIQVVYAGDDDLSPTNRNHLLTLAASGPAITFLNILTVFDDTTLKLKTGGWAIKPFAALASPFEKVILADADAVFLQPPEALLQHDAFVNKGVLLFHDRLLWKHAFEGRHEWWRDQIRRPSKEMDTSLVWTEDYAEEADSGLVVLDKSRPDTFMGLLHICWQNTYDVREETTYKITYGDKESWWLGLELAGAEYEFSKHYGGIVGWENVDDKERVGVCSFVIAHVDAKGRLLWYNGSLLKNKGQVGMEDVYEVPDKWMIDAEWVKGARKQDHSCMVGGEVRELTRDELDVLQRSIAAARQVDTLVRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R888</accession>
    <name>A0A8G1R888_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SUN domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_391211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUN family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519300.1">
        <property type="nucleotide sequence ID" value="XM_025656797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R888"/>
    <dbReference type="GeneID" id="37160199"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053088">
        <property type="entry name" value="Beta-glucosidase/SUN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034243973" description="SUN domain protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH61378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="50706" checksum="F0E43A6FD306F301" modified="2022-01-19" version="1">MKATSATVAFLAMTAVQAAKHAHDHGHHRSHRSVDAPVVKKSSSCQFPSGAGLIPITPYEVNGGWAMSPDQECKPGGYCPYACPAGQVSMQWDPEATSYTYPMSMNGGLYCDENGEIQKPFPDRPYCKDGTGVVSAKNKCKEQVSFCQTVLPGNEAMLIPTLVEELATLAVPDLSYWCETAAHFYINPPGYNTETACVWGTSANPYGNWSPYVAGANTDGDGNTYVKLGWNPIYLEPTTPFRNEVPEFGVEIECEGGGCNGLPCKIDPSVNGVNEMTGDSSVGAGGATFCVVTVPKGGKANVVVFDKGGDSASVPVSSSSVSSVVVSSSSSASSSSTSTSSIVPTTSSTSTVISTSSSTTSSTPTPTPSSTTTSSSTLSSSSTLSSSSTISTTSSSSITSRPTPSWTPSSSWKVSSSAALNWTVSASYTYKPHAMVETGSSHANPVAAAAVGSGSSQSSGTAQATQSAAVTDGAAVGSAVSKLSLIVAVLGAIVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R917</accession>
    <name>A0A8G1R917_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Histidine biosynthesis trifunctional protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <ecNumber evidence="19">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-ATP pyrophosphohydrolase</fullName>
                <ecNumber evidence="19">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Histidinol dehydrogenase</fullName>
                <shortName evidence="19">HDH</shortName>
                <ecNumber evidence="19">1.1.1.23</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BO85DRAFT_466711</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 19">In the C-terminal section; belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="19"/>
    <dbReference type="EC" id="3.6.1.31" evidence="19"/>
    <dbReference type="EC" id="1.1.1.23" evidence="19"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518012.1">
        <property type="nucleotide sequence ID" value="XM_025662139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R917"/>
    <dbReference type="GeneID" id="37165541"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11546">
        <property type="entry name" value="NTP-PPase_His4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1080:FF:000002">
        <property type="entry name" value="Histidine biosynthesis bifunctional protein HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1300:FF:000001">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.810:FF:000002">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000050">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="entry name" value="Phosphoribosyl-AMP cyclohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016298">
        <property type="entry name" value="Histidine_synth_trifunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF2">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001257">
        <property type="entry name" value="His_trifunctional"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="HisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 19" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphoribosyl-AMP cyclohydrolase" evidence="21">
        <location>
            <begin position="221"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="390"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RAH60090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="866" mass="92324" checksum="968A9D7417EB8623" modified="2022-01-19" version="1">MATPLLVSYDPASPSSGLSLKQIAYFGRVLVKVSSLAQAEDFLKRNFRLLDVYVDATAITSTGDLVDILNAGAAKIFISLNQLTALSQEQSVPSSRLVVYAAESQVDAFKTWVGESTEHKDAGLSTDSSAVKAIAEKLGMNLEAQNLYRTYTSIPTEETLKDTLAQGGVSVVSADALTFEHKEPNGKIVAASLIAARAVADQSNGLYATTVTDERGTCLGLVWSNDESIAEALRTGTGVYQSRKRGLWYKGQSSGDVQELIRVGFDCDSDCLVFVVNQIGRGFCHLGTASCFGPYNGLARLQKTLQARKADAPAGSYTARLFNEPKLTQAKIMEEADELCRANTKEEIAFEAADLLYFALTRCVAAGVSLEDVERNLDLKSLKVKRRKGDAKGPWAEKAGLAESKPAPEPAKPAEPAPKADEPMQMTRVVTASTPENVVQDYLKRPSQKSNDAIVALVRPIIDDVRKNGDAGVLKYTHKFEKATSLTSPVLSAPFPPELMKLSPETQEAIDVSISNIAKFHSAQKDSNEGLKVETMPGVVCSRFSRPIERVGLYIPGGTAVLPSTAMMLGVPAMVAGCKKLVFASPPRADGSISPEIVYVAHKVGAESIVLAGGAQAVAAMAYGTESVSKVDKILGPGNQFVTAAKMLVANDTSAGVSIDMPAGPSEVLVIADKDANPAFVASDLLSQAEHGVDSQVILIAIDLNEEQLQAIEKEVDVQAKALPRVDIVKGSLAHSVTFVVRDLEEAMALSNDYAPEHLILQIQNAEAAVEKVQNAGSVFIGQWTPESVGDYSAGVNHSLPTYGYAKQYSGVNLGSFLKHITSSNLTADGLLGLSRTVEQLAAVEGLDAHKRAVSIRVAHMKKQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R960</accession>
    <name>A0A8G1R960_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_445299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519810.1">
        <property type="nucleotide sequence ID" value="XM_025659229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R960"/>
    <dbReference type="GeneID" id="37162631"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH61888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="62" mass="6647" checksum="7FF7460F8F855268" modified="2022-01-19" version="1">MNRFPVLSKSCYGSLMDTLRFTSAAPLSLSPSLLMDCCPSVAAGNSLVETNRLALIDASRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9I0</accession>
    <name>A0A8G1R9I0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LEA domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_485477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518252.1">
        <property type="nucleotide sequence ID" value="XM_025663330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9I0"/>
    <dbReference type="GeneID" id="37166732"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="15213" checksum="CB4286E7E8A1B352" modified="2022-01-19" version="1">MSFLARIAPAARSASLSLRPTTTPALSVGATRSISATARRDKGPIDATKETLKKADRKVSDAAVKGIEVGENAAEKVKGTVSSTASEAKAKTDELSGEASQVTGKGKGKAEETLGTAKGKAQEAAGEVKGKAQEAAGEVRGKAKETAGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9N4</accession>
    <name>A0A8G1R9N4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_267593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517227.1">
        <property type="nucleotide sequence ID" value="XM_025655066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9N4"/>
    <dbReference type="GeneID" id="37158468"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034385018" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10422" checksum="A2C8A3E4CDE624B0" modified="2022-01-19" version="1">MLPLLKYTAALLSTLPYTLAQTYTNCNPLEKTCSSDTGSTQSTLQLRRELVILYVSRSRRWMFSTLLTWQTSHARVGRPRRLCTGATRSIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA66</accession>
    <name>A0A8G1RA66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-arabinitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_361233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520828.1">
        <property type="nucleotide sequence ID" value="XM_025655584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA66"/>
    <dbReference type="GeneID" id="37158986"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH62906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="377" mass="41115" checksum="25400A532202A0FA" modified="2022-01-19" version="1">MFRSTLARQAAKALSWSPRPAVRAAAEQRSLDTFVRSLSSTALRLNKDDDIKKDPFLTATNKAPEGTLGETEGRFARTDENVKFEYPDDENMPRSPIVQGRGGMHFKRTLAQFSLENRVTLVTGGARGLGLTMSQAIVASGSDLAIVDLNREEAQDQAAKLVEQFQKENPGLESDQLPTVTAHYADVSNPESVNNAIAEVIEKHGKIDHLVTSAGFTENFDAISYPYDRMQKLWGVNVDGTYLFATGVAKHLMERKAPGSIVMIGSMSGAIVNVPQPQAPYNAAKAAVRHLASSFAVEWAQHGIRVNCISPGYMLTALTRKILEENPELRDKWISLIPTGKMGTPEDLMGAVTFLLSDASRYVTGADLRVDGGYTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBX7</accession>
    <name>A0A8G1RBX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain dehydrogenase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_388482</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519527.1">
        <property type="nucleotide sequence ID" value="XM_025656712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBX7"/>
    <dbReference type="GeneID" id="37160114"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH61605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="263" mass="27515" checksum="F7F1182DB2FBAE6A" modified="2022-01-19" version="1">MSINLTGKTCLVTGGAGGLGKAIATRFFAAGANVVICDVNEERLRQTSMDLAGPSGDARLKVIKTDITSATEVQALFDEIVAQFQKLDILINNAGIMDQFHAVGDLDEKLWDRVMAVNLTAPFLLSKLAVRNMLAQEIVNGSIVNIVSIAGKAGWMAGAAYTASKHGLVGLTKNTASYYGNKGIRCNALMMGGMETNITDAFMSNINLEGKDKAVALMTAAAAPMCDINRVAELCLSISCGPGAEIINGTCIPIDHGMSGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC30</accession>
    <name>A0A8G1RC30_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_444727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521370.1">
        <property type="nucleotide sequence ID" value="XM_025659095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC30"/>
    <dbReference type="GeneID" id="37162497"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034021390" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH63448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="32440" checksum="934036240D0A5AB2" modified="2022-01-19" version="1">MYPAYAALMIAFPILATSATKLTTTVVTTAPPTAYVQVFEANAVFYSSIFSILAGSIVNVDTVEDRTTIGTNCIHSLAVNCSLETVSFPPTFTIGPSTYIHSSDGSEQNSQQYTSNIDSRACRIFSSTQSASCEIFASYWYSDAHTSTSKHTKRHTTLKSSEINYHNLLITAGIEKLPTAVTTSQTQKRTATVPTATALASTTAAASSPSPDSQSHPSKAWVAGPVVGAVVGCGLIAAVLYWCLKRKRQKVLSADSGPIIQDPSEEIRGLGSPVKSAYKACMPAETQGTPVSELPADEPSCVQHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCD6</accession>
    <name>A0A8G1RCD6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_444839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521531.1">
        <property type="nucleotide sequence ID" value="XM_025659124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCD6"/>
    <dbReference type="GeneID" id="37162526"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="855" mass="93387" checksum="75A05E4A5C9754CC" modified="2022-01-19" version="1">MPGFYSYATSSHYAPSSPHSPVSTSRSISPTDGLHLDMSFLTDELLNDMAGGHMANNGIQGIPVGEDNPLSLVVPTISQAQGGMHANHLDPILSQLATAVETKLPQQDAAHLYEMRDLLSASHNRLIRMIQHQIDIIEYPSHSPGSSDSPGSPHNGYNYVCKLCPNGKRKSYTERGNFRRHVSDQHHSEFRYQCVHPRCSWAANRRDKVYYHMRNQHMYQVSRTQIDRKTIRQMPPRQCGLCPQPVNCWAEYFKCVANHCRVRKVGSTTSSASQSRRGSDDRGGGGNNGPGFGGNFFPGGGFGQFGPHQFYPGNNGGFSSTGAGQANSHYGNSFSGYRGATNRDDEEFTSGYSSVEADAVSDIAPSSSCCSSDVPHTVEVPAPSNITSQHLALMQMAERAESCDSVSHGEDCPPSTPGETDISNPGDKAYRRISRPSGSTDLTPKRGFPPMADDSSEKRCQGCGHIFDDCDKCRRLKGTSFQCHLCTDSSCKLHAFERDLKGSGEPQSSRQAIDEGDIGVLAHPLRADHCSLSPSEHPLESPSLGDYDRHTKPEEGYHLGARVSSGGRTLGLGASNDGEVHSGRPGSLSRDSPVGSEETCSPISLDTSYCQALPSLDTKVPREEVEAAHGYGIGKLMMTKELKQTLDMLSVAESTYQSYEILSFCVLNAVQEFFDQMLVSWLVCEAALLESVSLSYCIGGKGISGKQTESAISRRYVPYPWERMCYQSTARQIPRRKHSLLRTKLQVISGVLILRATVMKRKPLMNSFTDTSAEVSEPSKVGTELQVIEQGIHAAPSIEVMFSRGTEVVADAFSSLITGVMSATEEEMEYFKPLSAHISNLFTRGLWLGDESLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCF9</accession>
    <name>A0A8G1RCF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fusicoccadiene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_443969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520548.1">
        <property type="nucleotide sequence ID" value="XM_025658911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCF9"/>
    <dbReference type="GeneID" id="37162313"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="330" mass="37595" checksum="1872130467AB687F" modified="2022-01-19" version="1">MDQQFSYEASRDSYDDRGLAHGIPLRVHREGHRETKGALRAQADWNRLVSPIKGYNGGLGHKYSFMQVTVPGCLPERLEIISYANEFAFLYDDEMERLIDHGRDPAQSHAMVDAFGVPTSGSEEQPLSSPSSSTTSSRANRLQARVFKEMITIDKPRAITSMKAWSTFLQLASRSRACPARTLREYLPMRIIDAGELIWFGTLTFGMALTIPEDELEICMELARPGYAAISLTNDLFSWPKERQDAVQAKVDYVFNAVWIIMEEEGLSETAAMQVCEGEIRRYIAEYEHITCNAHRQQKLSRDTLAYLDAVRYSHVGNLVWSIYCPRYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCI5</accession>
    <name>A0A8G1RCI5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_363803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520126.1">
        <property type="nucleotide sequence ID" value="XM_025655674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCI5"/>
    <dbReference type="GeneID" id="37159076"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF50">
        <property type="entry name" value="ASSEMBLY CHAPERONE OF RPL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="364"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH62204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="420" mass="46672" checksum="35B6030C7C2CEF12" modified="2022-01-19" version="1">MGKSRPHNKKASKSRAKSVLGAGGSVSKQKMNEDPSKLLEQATIQLQTGQPDAALQLAQQALNNAPDNSPSQLVALNTVGEIYVELGEIDVAKQHFMRAIELDPNGTIPEAEGGGAEKFLWLAQLSEQGGKDSVQWFEKGVSSLRHIIQQLEQKPGPEEALELAEKKRKMANALCAVAEIYMTDLSWEEDAENRCESLITEALLVAPNAPEVLQTLASIRISQLRTEEAQAALRRSLDLWKDLPPEDLSIPDFATRISLSRLLMEVGMELEALEVLERLILEDDQSVEAWYLGGWCLQLLAGKQQAPKDADEEDGNTPEARRHASLVASREWLKQSLTLYDLVQYEDERLKEHALELVQEMNKEIGEDMDDDEAGEGEEDWEDEEIETAPDKVGSDRFPPAITRAKFIPAVRLRVANSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCL9</accession>
    <name>A0A8G1RCL9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Citrate lyase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_412803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519902.1">
        <property type="nucleotide sequence ID" value="XM_025657584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCL9"/>
    <dbReference type="GeneID" id="37160986"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000023">
        <property type="entry name" value="CitE, Citrate lyase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308:SF0">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308">
        <property type="entry name" value="LYASE BETA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="324" mass="35147" checksum="47FFA924F0A8E133" modified="2022-01-19" version="1">MAARNTLRRALLYIPGSSQRFIDKSRTLTADCVAYDLEDSVTPHKKAEARSLVRRALDEPAPQGIRERAVRINSVDSGLALGDLTEVLKSPNLTTIVIPKVNTPSDLTFVNDVITHTLSQQQQTQDPSTPRTPISLLALVESAKSLTNLTQICASTPLLQGLIFAAEDFALDLSITRTPSLTEFLFARSMIATAARAANLPSTIDLVCTAYKSTKGDGSPPAVLEEECRDGRRLGFNGKQCIHPSQVETAQAIFGPDQEEVKWAVRVCVADEKAARAGRGAWTLDGKMIDVPVAEKARAVVRKAEACGFDVGGLREEWGHQEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD07</accession>
    <name>A0A8G1RD07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS allantoate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_411384</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521344.1">
        <property type="nucleotide sequence ID" value="XM_025657521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD07"/>
    <dbReference type="GeneID" id="37160923"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000699">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF81">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH63422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="518" mass="57875" checksum="665AACABD15BBF4E" modified="2022-01-19" version="1">MTDSASDAKLQDPEKSIPVTTKVDDIDIGQTTHLDEAEIFLHEHGISHDQMQEMLDDPVRTKKLRRRIDMILLPLMCGTYCLQYIDKQALSYSAVFDLFTNAHINSNDYSWLASIFYFGYLFWEYPASYIAQRLPIGTVVSSFVIAWGSILMITAACNNFTGLAICRFLLGCFESPITPCFMMIVGMWYLRQEQPFRAGIFYCCNGVGSMVGGLLTYAIGQLNTFPVWRAVFLICGGATITWGVVMMIFLPNSILSSKRFTVEEKVLLIGRGRKNQTGILNRWIKWYQIREAFIDPQVWLLFLFTLLNETINGGVANFGKLIIKGLVTSPLLTTVLGIPQGAFQVLFILTGTYLSTRIPNIRTLIMIAYLIPTVIGVCLLWKLPREREYGVLFGYYIIGSFVTSLVLALQLPSSNMGGYTKRVTATAFVFLAYCIGNIIGPHAFLASEAPVYQTGCKLILACAVCQIVCAGGIRVLLVRRNKERDLSSTSSTVGGDGDGDGVMEDLTDFENPRFRYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDQ6</accession>
    <name>A0A8G1RDQ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_446548</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519312.1">
        <property type="nucleotide sequence ID" value="XM_025659532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDQ6"/>
    <dbReference type="GeneID" id="37162934"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="191"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH61390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="414" mass="44725" checksum="1C77834466ADB255" modified="2022-01-19" version="1">MATQTRMEEIISQTIDTFSGSLRELSLKIHQNPELCYGEHMAHDAICNYLVKWSSLYGITVIRKAYGLETSFLAEYVNGDGEVVDFCAEYDALPEIGHGCGHNLIAISSIASFLGLAAVMERTGIPGKVRLLGTPAEEGGGGKIKLIEAGALKYTTASLMSHPTPQFPHMPAGSAGVAFGSCLAATGLLANFTGKPAHAAQMPWAGVNALDAATLAYQAVGLLRQHIRPSDRINIIIPEGGTAHNIIPDKAQVRVNVRSETLKEMNALRERVENCMKGAALATGCAVDIVPAMDPYADIRPNESLCTEFTRYMGSKGMDYYCDLQKKDIGAFSTDMGNISYKVPSFHGHFFIPTPPGTAMHTEAFRDAAKTEEAHDIAMSVGKGMAVAGLKVLADKSFAAQMKEYFEDDKEFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1REB1</accession>
    <name>A0A8G1REB1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_387890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521429.1">
        <property type="nucleotide sequence ID" value="XM_025656688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1REB1"/>
    <dbReference type="GeneID" id="37160090"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="3">
        <location>
            <begin position="344"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH63507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="744" mass="85989" checksum="74E04519E605364E" modified="2022-01-19" version="1">MYDREESVIKAHPKTFEWIFDADSRQGKDETEFRHGFSAWLETDNYGPIYWVTGKPGSGKSTLMKYLYEHPATHASFRKWAGALPISTAGFFSWASGSKEQRSKSGLLRSLLYQFLSINPHLIPRTFPNLWTKIRTMTSKERIALHLEWDIDELLEAFQLFMGAALSEMKICIFIDGLDEFDEDHQELPNFFKKYSLGGRVKMCLSSRPWNMFEAAFQTTGPSVKLQEITQSDLYQYATDRLRENAVVRHLLGRTIEESEALRQAIVDKADGVFLWIKLALNDILKEFDPKQGLAGLRDRLDQLPGELDGLYEKFLLQDQTDTQIAETATFFLLIEARETVAEFVNDTSASSLTVWELAFALKQGYDDYATDGDLAQVSDVFIQERCSDTIECMHQRFAGLLSLQGRPSQNHHRSIKFSGNVDGDSASIRRLANTKVTFIHRTVRGWLRVDSVRRGLEQRISAGFDPHLRLLRSHVLRFKRPMEEIEHHRRFDEWWPDVTLAMTHARYIVNDAEKLQRRFLNELNRTLSWLWDTNADPNDHWAAKAFGFFHVRKKAPSIWHPFLCLATKFGLTTYVSEELDAWISQGNHGVLGHGILNYDEKTTPLLTYATEFLCSRERSIYPLSDPNMVHNLLERRHYINPGPNHEYIDFETKRPMTSWVKLLRHLRDAHRRHLIGYFDTDPNGITRWAEIVRLFIRGGADVDAVIAADPWDPEITMVGVMEMLADTYCAVELEDLKRLIGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1REE2</accession>
    <name>A0A8G1REE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_501331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519687.1">
        <property type="nucleotide sequence ID" value="XM_025664169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1REE2"/>
    <dbReference type="GeneID" id="37167571"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="568" mass="62923" checksum="DE9F744D7EC9F954" modified="2022-01-19" version="1">MTAILSASNEGRSRFSPDPLRSPIAQTYFLEEPNVATAKFNLPAYHRKDRSDAVVSSPPRSASPSPDFTITAVENLPPTPATLSSLSLMSEGHDDDELVLPSYDSSQFAQKEPEALSDVSVDSSADFPRLTQAPAADDSTIEDEPSRHVDYLSHEWRQEDIWASWRYVVARRNIYENGTRLENASWRTWAKLKLNLGTVSPEALNWLKDCDVTWLYGPLKTCNKREKAFNGSPPPSRLETPTLYPDRKPILKKRTASETILQRSLSQHTLLQHAGAILKAQEAEINRNRPPLQRVSSEFGHMLSKSSTTPVGGTAKGTATNTSTSATPSERRHIHFNNEVVQCIAVEAKEEDDGWPAHFGDESSEDGIVMMKHIHSDSSLSDKGTPRGSVTGENKTIAPLPSTTLKYRWDASDHADDLPDCRGDACGNGQTTSDSPASSMMGRWSSYFLNSTSPTSSGAEKSTRKNARSGRNNTPSANFLLDEEENDVEFDWEPSRNSYGLGSLSRPWFVNPEDDEELDYYFHSMSPGGTTPNEDDEPLSASIFDRVADTVNTAKDIAHVIWNVGWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RF55</accession>
    <name>A0A8G1RF55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_444581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521207.1">
        <property type="nucleotide sequence ID" value="XM_025659048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RF55"/>
    <dbReference type="GeneID" id="37162450"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="362"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH63285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="394" mass="42768" checksum="BE6F65BFE12AFFED" modified="2022-01-19" version="1">MDFYTSPHNHTKNPGSAVSPTASATTSTREPKLQLPSTTDPPGPSNPPKPLVWLIFGATGHMGRSLVKTALSRNDLVSAVGRTFETTPAAMSKLEEEHPNKCLGLLCDVRARPTVQRVIDATIARFGRIDIIANCSGYGVIGACEDQDEYDIRDQFETNFTGTLNMIQLSLPHFRERGAGRYLIFSSTSGALGVPGLGPYCASKYAVEGLMESMLYEVDQFNIKTTLVEPGHMRRDDVGDLVGGEESIFGGGGYGVEDEQDSANKLALGSPLPLYGHFLVKPPSEPYNTPTAPAAHAKRMLMWLGDKQPASAVKAAHLVWQLGHCSYPPLRLILGTYAVESIRDRLKCIIEEIEDWKYLSFPTGEQQGQQQGQGKDKGPASVSGGREGDEMDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGX0</accession>
    <name>A0A8G1VGX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_506058</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510653.1">
        <property type="nucleotide sequence ID" value="XM_025664365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGX0"/>
    <dbReference type="GeneID" id="37167767"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF54">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="53"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH52731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="505" mass="55469" checksum="F7CDDBD05A347347" modified="2022-01-19" version="1">MEQDFAKEGKVGADVAHLESIAYAGFSDEEAAILRAYEGKRGKQVIRKIDRHIIPVLGLLYLFSHVDRSNLGNAKIEGMGRDLNLVGNQYNIASSLFFVPYIIFEIPSNVMLKKTRPSFWLAAQVLAWGIVMTCMGAVQGFASLTACRVLLGICEAGFFPGAVYLVTQWYPPNVIQQRLAVLYTASAISGAFSGLLAFGISKMDGIRGIAGWRWIFILEGIVPSAFSLFLPLLLPDSPEKVGWLTAEEKQYLDLRFRQSGNRSTTGEGDKFSWSLLLNTMLDWKILLGALMGMVNAAPNAAFSYTMPTIINKLGFESQDAQLLTIPPYFCGAVSSWLSSRLADRFTWRFPFIVGPMALLLVSFLILLILSANVEAYKGPMYFAIILAQIGIYPLLPGISAWTGNNLPQSWKRSIGIAWLLAAANTACFIGTNVFLDDQAPHYVVGYGVSLGIIAMGIIAACSLEYALWRLNQHKDGVSESEVLATYTPDQLAAMGEKSPIFKYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VH47</accession>
    <name>A0A8G1VH47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_492620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510876.1">
        <property type="nucleotide sequence ID" value="XM_025663787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VH47"/>
    <dbReference type="GeneID" id="37167189"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034829673" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="114"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH52954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="588" mass="64660" checksum="AD202BDCAE464305" modified="2022-01-19" version="1">MASALLWLSLLGSSTLSSALDTSNTPTIKRADTGSSSNTTSSIPTATLNNTVFVGRSLPEFEQELFLGIKFADEPGRFTPSTLKTAYRANDSDNGVYDASSASGLQTSSGTVLYNATEYGYDCPGYGSDETELAEEGYARFDENCMNLNVIRPKRENEDELLPVMIWIFGGGWVQGATADPRYNMSYIVRQGALNDKPVLGVSINYRVAAFGFLDSVEVMESGNTNLGLRDQRVAMHWVKQNIKAFGGDPDKITIWGESAGAYSVGAHLVTNDGDNEGLFRAAIMESGNAVGPPYNGTDWYQPMYDQIVNATNCTTSSNTLQCLREVPFSTIYTAANLGLEWFATIDGTFIKEYPQISYTEGRFAKVPILHGTNTDEGVSFGTTGVNTDAEAIQQLTASKRWVLNETQATTLLSHYPNISALGCPYGWGNTTWPKLGYEYKRYESMAGDLCMVAPRRLLSQKMKEYDDEGQQVFAYRWDVAALNDSSTIGVAHFAEIPFVFANPVQNITPLGSDPSRLELGNLAARMWTAFVTDLDPNGHGVSGIPTWPKYNLSDPQDFVFRVPRNESYVEKDTFRTEGIDYINTIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHB0</accession>
    <name>A0A8G1VHB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division cycle protein 48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_200708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510352.1">
        <property type="nucleotide sequence ID" value="XM_025654531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHB0"/>
    <dbReference type="GeneID" id="37157933"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="43"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="143"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="255"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="529"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="726"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="788"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="726"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="740"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH52430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="820" mass="90304" checksum="9AEE01A0D4C691D1" modified="2022-01-19" version="1">MSAEPDHTHDKKRVNLHDASGADKKEELDTSTAILKKKKKPNSLIVTDAVNDDNSVIALSNNTMDTLQLFRGDTVLVKGKKRKDTVLIVLADDDLDDGSARINRVVRHNLRVKHGDIITVHPCPDIKYAKRIAVLPIADTVEGLTGSLFDVYLAPYFREAYRPVRQGDLFTVRGGMRQVEFKVVEVDPPEYGIVAQDTIIHCEGEPIQREDEEGNLNEVGYDDIGGCRKQMAQIRELVELPLRHPQLFKSIGIKPPRGILMYGPPGTGKTLMARAVANETGAFFFLINGPEIMSKMAGESESNLRKAFEEAEKNSPAIIFIDEIDSIAPKREKTNGEVERRVVSQLLTLMDGMKARSNVVVMAATNRPNSIDPALRRFGRFDREVDIGIPDPTGRLEILSIHTKNMKLGDDVDLETIAAETHGYVGSDLASLCSEAAMQQIREKMDLIDLDEDTIDAEVLDSLGVTMENFRYALGVSNPSALREVAVVEVPNVRWEDIGGLEEVKRELIESVQYPVDHPEKFQKFGLSPSRGVLFYGPPGTGKTMLAKAVANECAANFISVKGPELLSMWFGESESNIRDIFDKARAAAPCVVFLDELDSIAKSRGGSVGDAGGASDRVVNQLLTEMDGMTSKKNVFVIGATNRPEQLDAALVRPGRLDTLVYVPLPDQASRESILKAQLRKTPIAGDIDLSFIASKTHGFSGADLGFVTQRAVKLAIKQSIGADIERQKQREAQGEDVKMEDEEVEEEDPVPELTRAHFEEAMKSARRSVSDVEIRRYEAFAQSLKNSGGSSFFRFPSAGEVTDNNTFGEAGNDDSLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHR5</accession>
    <name>A0A8G1VHR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tat pathway signal sequence domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_507349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TolB family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510414.1">
        <property type="nucleotide sequence ID" value="XM_025664399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHR5"/>
    <dbReference type="GeneID" id="37167801"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36842:SF1">
        <property type="entry name" value="PROTEIN TOLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36842">
        <property type="entry name" value="PROTEIN TOLB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69304">
        <property type="entry name" value="Tricorn protease N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034832130" evidence="2">
        <location>
            <begin position="25"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="682" mass="74849" checksum="1E5B7DB856A28597" modified="2022-01-19" version="1">MFVSKTWAWLALATATLVSGASHAEDHARREATSGTKLGTFLHNRISPNYSELYIAEPDGSNEKLLLGSNTVYDFRASWSPDAKHVYFTSERRGDGQADIYRVAINGTSTEGAEIEEVALSPGVDDSASISPDGKMLAFATSRYNQTSQIMLMVLETGSLKNLTLIPGISEAANSSLPNGYFKPTWSPDGEWIVFTSDRNTPWRGHSDGSGWEHTQELSIYAARPNGTDFRLVSSRSNYTQGSPRFSPNGKRLVFYEMLTEDTYNGRLQPELLEGSYLNTSIVSIDFATGGDRIVHATGDGTKISPSFVTDDVIGYVMKESASNGIYYTSISGKNYTQYQTIPMNTMTPAIRSPAWSPDGKYIIYEKQGPTGGSTSTSKTQYSPLWSFDPDWDYRFTDVFPMAKRGGCPMMAMSQQMEGAAESNLMRLQMNGTDQVTLFETKKGMINPSIAEGFNARAYQGNWGPNDTNITFGYGAYFVGRQSSPGFIFSVTPEGTGVTLLAGNNITNYGFPSYNHDGTQVVFRTWPGTASNGTTIGTTGLAIVDLPSRQVTQLTTEWDNLPAFSPDGKKILFTRRTNLDNIGDNYDIFTMNPDGSELTKLTPSIASDAHAVWTQDGRILYSTAMFGFQQEAPLYDDSMQPYAIIVLMEADGSNKTVLSNSLWEDAMPMFAPAHVMESHCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHW2</accession>
    <name>A0A8G1VHW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GXWXG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_504024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511746.1">
        <property type="nucleotide sequence ID" value="XM_025664276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHW2"/>
    <dbReference type="GeneID" id="37167678"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.580">
        <property type="entry name" value="GXWXG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025568">
        <property type="entry name" value="DUF4334"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025951">
        <property type="entry name" value="GXWXG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14232">
        <property type="entry name" value="DUF4334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14231">
        <property type="entry name" value="GXWXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GXWXG" evidence="1">
        <location>
            <begin position="31"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4334" evidence="2">
        <location>
            <begin position="99"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16968" checksum="9A7703672CF2CC39" modified="2022-01-19" version="1">MSTMTQTPAGGTFLSLTKRKARVEPSEVQNVFDLLPAVSIEFIFGEWEAHLLATGHPSDPKAAALLPIFKVFRSRTSVDKYSLVGGEKKHLPGWGNLFLAEMTYRGISSAAMIYGDCPVVDYLRYVDNNTIAGAQWSLNQDNSGVLYFYLTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIB5</accession>
    <name>A0A8G1VIB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_165490</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="14"/>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511014.1">
        <property type="nucleotide sequence ID" value="XM_025654261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIB5"/>
    <dbReference type="GeneID" id="37157663"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000008">
        <property type="entry name" value="Beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF5">
        <property type="entry name" value="BETA-GLUCOSIDASE M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034223762" description="beta-glucosidase" evidence="15">
        <location>
            <begin position="18"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="16">
        <location>
            <begin position="729"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH53092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="806" mass="87430" checksum="3B0AB8583B84B562" modified="2022-01-19" version="1">MKVSLTLYAAALQLADAAVVQKRTVDVAELEHYWSYGRSEPVYPTPETSGSGDWEEAFTKAKSLVAQMTDDEKNNITYGYTSTTNGCSGMSGGVPRLGYPGMCLQDAASGVRGTDMVNAYASGLHIGASWNRDLAYEHAHYMGAEFKRKGANVALGPVVGPLGRMARGGRNWEGYSNDPYLSGSLVQNTIRGLQESVIACVKHFIGNEQETNRNTPQLLEDSYNQSVSSNIDDKTIHELYLWPFQDAVKAGAGAVMCSYNRINNSYGCQNSKNLNGLLKGELGFQGFVVSDWNAQQSGIASAAAGLDMVMPDSVYWENGNLSLAVRNGSLSSTRLDDMVTRIVAAWYKYAELEDPGFGMPISLLEPHEPVDARDPASKATILQEAIEGHVLVKNTDNALPLKEPKILSLFGYDAIAAQRNTMDDLSWSLWTMGLDNTLSYPNGTAVDPSHLKYMFLSSTNPSENGPGVALNGTMISGGGSGSSTPSYIDAPFDAFQRQAYEDNTFLAWDFASQSPVVNPASEACLVFINEAAAEGWDRPYVADPYSDTLVENVASQCNNTMVIIHNAGIRLVDRWVDNPNITAVIYGHLPGQDSGRALVEIMYGKQSPSGRLPYTVAKNASDYGALLSPVVPSGTKDLYYPQDNFTEGVYIDYKAFEQKNITPRYEFGYGLTYSTFDYSGLKISINTGANTDYLPPNSTIEEGGIPALWDVVATVTCSVANTGSVAAAEVAQLYLGIPGGPAKVLRGFEKKLIQPGHHTKVQFDLTRRDLSSWDVVNQVWGLQKGDYSVYVGKSVLDIQLTGTLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ21</accession>
    <name>A0A8G1VJ21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbonyl reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_452607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512167.1">
        <property type="nucleotide sequence ID" value="XM_025660862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ21"/>
    <dbReference type="GeneID" id="37164264"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490">
        <property type="entry name" value="(+)-NEOMENTHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490:SF99">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH54245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="246" mass="26110" checksum="E834D34767485597" modified="2022-01-19" version="1">MASPDSTIVLITGANQGLGFEVAKKLATDHPGYHVLMGYRDAAKGGEAIAKLKSQGLTVDGVIIDVTDDTSIQSAAKQVADQFGRLDVLINNAGVITEGRLPEGTSLRQTWQAGFDINTTGQVVTTEAFIPLLEKAAVPRIVFVSSALGSCTGRLDPKDQFASFQFPAYRSSKAALNMIACHYANLYGPKGWKVNASDPGFCATNFNRFRGWGTPESGALQTVHLATLDKDGPNGTFSNTDGPLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ78</accession>
    <name>A0A8G1VJ78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_463859</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510385.1">
        <property type="nucleotide sequence ID" value="XM_025661945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ78"/>
    <dbReference type="GeneID" id="37165347"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
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    </dbReference>
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        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="700"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="745"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="774"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="820"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="848"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="36"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RAH52463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="917" mass="101841" checksum="5855AAFF4B320A09" modified="2022-01-19" version="1">MSLSTTTTVEKRLLATAEHLNAPNKSQPTSVPWVHPHLEQGVVPIKGRQLRASQPIRQGELLMIDVPYALIPVVDDPASSDSLLCSNPTCSRQTQRSSGRISCPNRCLADVVWCGPTCQEADQLRHEFECTWLQRYAAPTRTKWGEYDFGMMWLIVRILASRHMERQQPFDTEIQTNQRFKGGWDAIQSFCGSIDSWAHSQVRSWTALVKKYLRSSPVLPHDLSADEIVALICREEANSFGLYPRETGVYPVPEPPVDRGEQFAAAVYPRAAIANHSCSPNIMHKPDHHGRMVFTASRDIAAGEECCISYFDLSKRVDLKSRRDHLQGLFRPNPARSRPNAVLLMQVRGGNLETSEAEWEHAQLSKMDTKYRQPDFGVAEASDYASEPPETPNITAGSQHLHRKLGGKEVQLFAVGGAIGTSLFVQAGAMLPKAGPAGLLIGFLAYTPIILAVNQCFAEMVCYLPIPSPFIRLAGHWVDDALSFAMGWNFFFTMALGIPYEIVAINILLTYWTDRVPVAAVVVIMLVLYTLLNVFTVRFFGVSEFYLSFFKIFLMVGLLLYTVVTMVGGNPRHDVYGFRYWRDPGAFVSYIEPGSVGRFCGVLACMVQASFTMVGPEYISMAAAEAARPRRVMRKAYAAYPWRLVTFFVLGVLSMGILIPYNDPTLAATLEGSGHESGTGAASPYVISMNHFNIRVLPDIVNALIMTSVFSAGNNLVFSAARTLHGMALEGRAPSLFARCNRNGLPYYAVGASLAFCLLGFLQVSNSSSTVLNWLVGIIVASYLLNYVGTCITYLHFYAALRRQGISRDTLPYKGVLQPYAGWFALVGTIVMTLIIGFEIFLDGQWDVQTFFLDYTMVGFFVVAFGFWKVVKRTRYVWPGTADLGLGGLKKEIDEYEAGVVVPVRRGVARVWDGLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ80</accession>
    <name>A0A8G1VJ80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_380192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="292" mass="32775" checksum="612E28E3EFDD76F9" modified="2022-01-19" version="1">MSGLRVSVHTVPPIPCVDHVSHRQNTTWSPETCTLIYSENEAVLVDTAITINQNKDLVEWIGKTAPGRKLSYIYITHGHADHFLGLPLLLQHFPEAKAVATKATVCHIEQQISEEGFSAWLAFFPGDQLSTQHRLPEALPSNNQFLLEGRWVFEAIECGHSDTFDSTVLWVPDLRLAVCGDVVYGDVHQMLFEANTPEKREEWIRAVEKVEALNPVYVVPGHRNADEMDGIWHLEATKKYIRDFMGLLEQKPQTVSELYSAMMAKYPNRFNPMVLGWGCAGAHLSGEVPSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJV3</accession>
    <name>A0A8G1VJV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_451095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025660515.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="37163917"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH55851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="186" mass="20567" checksum="69EBF51D40D1C091" modified="2022-01-19" version="1">MLEYACGTGPVSLTLAPYVSKIVGLDVSDNMISEYNNNAKEAGYEDKMVALKGDLLAESAPAELSGPEYFDFDLVVVSMALHHFERPELAMARFGERLKKGGVCVIVDIVPDDHHHGHCHNVEHGFGDAAHTVKSHGFTMDQMKQLYEEAGLGTGFKYDISKEQVVFRKEGKEHLKTIFIARGQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK21</accession>
    <name>A0A8G1VK21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein BNI4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_491038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512769.1">
        <property type="nucleotide sequence ID" value="XM_025663691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK21"/>
    <dbReference type="GeneID" id="37167093"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="764" mass="82068" checksum="E3B340213059ACC8" modified="2022-01-19" version="1">MAALVQTIPQQSGTVSVLQTRPSSSSGTFTTSSQPGQQQNPRNSTMSWNPYNNNGSSGNYRVGHQVVAPYAFTSTPSPSNSTNMQARQSLSPHLRPEHRTSSAPSVPQGPASPVNAGVNSRFAHPAAGSVSTSSSNSSVHSYMSKDDSAIPTRQIRTDAPLRPLSTVNLPSPSSSNFMNISSPTVARPSPDRYRRGNRRPENAAGTQPASTQPNGPAPARSATLATDDSALHMSTPSLAGVSLDAPRRIGHVRVPSADDTTRADKPQTELAKRYRRRSWGNIDNAGLINMQLHLPTSSPTPTAGGHDYFDQSTRPRSAQSHKEVQGSIPSAHSSTSSVRDAGHSESASSSSKSGPKTDDSKRPNKPSPLSQPVEVDSKPPTPKASQPSTTPNPAPTESLASQRLAEITKGDPKRPGKSRLRRAFSFGSASELLKASSQNKREAMAAERARRELLQEELGPEQAAIAEQQEASGLGESIYSSHHQGRIFNSSTDNLSVSSTASSASIMLRKMGKGMKRSTRSLVGLFRPKSVVSTSSTDGVMIEPMAPQLSVVNIEAERKSTAVTSDSQDHPLGNTLFSKVETDAANAVSHEDAALDKSRKSIVGGDRERAEVLAAVRKGILKKTYSDPANQTYVLKSSENLNGNDSPHSSVPSTPEDQTRSGNRRTDAVKIAGEDDYLSEGRFQTSESKSAPITPQAVMPKSLVFSPRIQFHETWPSGEYDRRGDIATCNRLTPLLAQQIKEELNNFKMEMEVHETSKIYTHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK69</accession>
    <name>A0A8G1VK69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_450870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514148.1">
        <property type="nucleotide sequence ID" value="XM_025660474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK69"/>
    <dbReference type="GeneID" id="37163876"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="126" mass="14883" checksum="C33A4F6ECC804A51" modified="2022-01-19" version="1">MSIGKIIGKIIIIPIIIIIAICVGIYLLIKHRRERKRERREDNLRAQYYRQQYQQQYMYPHMQMQSQQQQQQPRTPAPPYYNQAYAAGQQPVAMNEGEYGYSETMMKKPEPVVYPVQQQHPGSEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK87</accession>
    <name>A0A8G1VK87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="13">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 13">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_375580</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514208.1">
        <property type="nucleotide sequence ID" value="XM_025656177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK87"/>
    <dbReference type="GeneID" id="37159579"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000018">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="18"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH56286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="97" mass="10998" checksum="766164BF6B4030AE" modified="2022-01-19" version="1" fragment="single">SEYEVSLVEEHELTAGPLSLLQTATRTHTQVLISCRNNRKLLARVKAFDRHCNMVLENVKEMWTEKPKGGNGKGVNKDRFISKMFLRGDSVILVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKA0</accession>
    <name>A0A8G1VKA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_497036</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514253.1">
        <property type="nucleotide sequence ID" value="XM_025663976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKA0"/>
    <dbReference type="GeneID" id="37167378"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="28"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH56331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="537" mass="58635" checksum="A879277750F222C3" modified="2022-01-19" version="1">MGAAGGGFSPQAIKQVPPAARGLYIWLAIIWASYCGGLHGFNTSNISGSMQMEQWDPDFGWDKLSSTAVSNNEGWVVSSMLLGQTVGVLLAGPLGERRGRKAVILAAAICYAIGAVLMAANLGSFAELLVGRVLSGLGSGLGMSAGPVYISEVAPLELRGMMTTFYNVSIMSGVTGSYWINYASYLVIPDSSSWQWRTTLVLQSIPAIILFLGYPFFPESPRYLMMRGRVDAARRSLSRLRGGMDENTEYFAREYTELLSKLDTTSTPTTPTKAFVSLLHECINHPPTRKILLFVTLIQTFFIMSGGNSITYYTPDILESIGLGHSQILLFTAIYGLVKVLSVFFYAWFLTERFGRRPLLLIGSTINVVCLLYLTCYLALSPPSSSGTASPSAASYVCIVAICLYAVGYGFGWAPVFSLTASEICPTRIRGTVVTIAFTYQNLLNFGITRGFPSMTESMQSWGPFALFTAFTTLATVWAGVGFPECKGRSMERMEELFTKSWWKIGWAKVPEERVVEDGQEVADDGEKGSSSHEEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKG5</accession>
    <name>A0A8G1VKG5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_480896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511615.1">
        <property type="nucleotide sequence ID" value="XM_025663033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKG5"/>
    <dbReference type="GeneID" id="37166435"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="89"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="319" mass="35207" checksum="F2E61DD96ABBCB9C" modified="2022-01-19" version="1">MSPITRPPLHPSLSAIHQTIPTMDISTPEKRRVYRDYLTTHFTLENTLKGHESTIAYQEVDIPGPAGPLRATIFRPKHTTLDVSSTPGILHMHGGGHSTGNRFMGFTVLDWVESLSAVIMTAEYRLAPEHPQPAQLEDSYAALKWMSEHAHDLGFNPSKLVVCGGSAGGNLAAGLSLLARDRAGPAIKGQVLMYPWVDDSVEWNSMEQFGDIAPLTKADAAQASDFAFGVNREFADMYTVPLRAESFVGLPETFIDVGEADVFRDQDLAYAARLWRDGVATELHVWPGCWHGFDAFVPEAEVSRRAREARLGWLKRLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLL6</accession>
    <name>A0A8G1VLL6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">SNF2-family ATP dependent chromatin remodeling factor snf21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_460212</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514777.1">
        <property type="nucleotide sequence ID" value="XM_025661703.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37165105"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17996">
        <property type="entry name" value="DEXHc_SMARCA2_SMARCA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000052">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000008">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000843">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000072">
        <property type="entry name" value="Putative chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014978">
        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029295">
        <property type="entry name" value="SnAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08880">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14619">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00951">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01314">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51666">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="QLQ" evidence="17">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="HSA" evidence="16">
        <location>
            <begin position="365"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="551"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="862"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="13">
        <location>
            <begin position="1261"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="65"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1156"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1354"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1393"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1156"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1186"/>
            <end position="1196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH56855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1413" mass="161192" checksum="FE85257D7631F89B" modified="2022-01-19" version="1">MASLQSAPSMAAGNMSLPPNITQQQIQEVFQKFKQMQEQGVRHDDPEYLKAHNLLSAFQRQQAYHKQRQMQQQQLQVQQRQQQLNGSNTEAVAANGMNGRNNSIPNATNTNTPDASATGGQQPATQGAPQKGAAGTGNSFSAEQLATLRNQILAFKMLSKNLPIPARVQQQLFPSKKQETPAPSENVAAAEGVLEATAQSKPDQPATATEAPQHKDFYQNFQSPYDLIPKTVSFTDHASRANRMRIPALMPPGIDLEQVREEREIALYNRINARKAELAELPTNIGAWDSSQSDTATGDDSVKLKALIEYKMLNLLPKQRLFRKQIQNEMFHFDNLGMTANRSSHRRMKKQSLREARITEKLEKQQRDARETREKRKQYDHLQAILTHGAELQTAAAQQRTRMQKLGRAMLQHHQHMEREEQRRVERTAKQRLQALKANDEETYLKLLGQAKDSRISHLLKQTDNFLKQLAASVREQQRSLAERYGEEDQFFEEDEEEEIASGSEDEGDGKKKIDYYAVAHRIKEEVTVQPSILVGGTLKEYQMKGLQWMISLYNNNLNGILADEMGLGKTIQTISLITYIIERKKNNGPFLVIVPLSTLTNWNLEFEKWAPSVSRVVYKGPPNARKQQQQQIRWGNFQVLLTTYEYIIKDRPILSKIKWTHMIVDEGHRMKNTQSKLSSTLSQYYTSRYRLILTGTPLQNNLPELWALLNFVLPNIFKSVKSFDEWFNTPFANTGGQDRMELSEEEQLLVIRRLHKVLRPFLLRRLKKDVEKDLPDKQERVIKCRFSALQAKLYRQLVTHNKMAVSDGKGGKTGMRGLSNMLMQLRKLCNHPFVFEPVEDQMNPGRGTNDLIWRTAGKFELLDRILPKFRATGHRVLMFFQMTQIMNIMEDFLRLRGLKYLRLDGSTKSDDRSDLLKLFNAPDSEYFCFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQKNEVRILRLISSNSVEEKILERAQFKLDMDGKVIQAGKFDNKSTNEERDALLRTLLETAEAADQIGDQEEMDDDDLNEIMARSDEELTAFQRIDKERQKTVPYGSGHKYPRLMCEEELPDIYLTEDNPVTEEVDVELAGRGARERKITRYDDGLTEEQWLMAVDADDDTIEDAIARKEARVERRRVNKEKRQKKTVGDSSPEPSRENSETPQPKKRRRGPAPKRKAEEVVEETPQPKRKRGRQAKPVETLSPEDRATLQRIVNTVYQALMDMEAELPADSSDSEDGPVTRSIIEPFMKPPPKSHYPDYYMVIQNPIAMDMIKKKINREEYQSLKDFRNDIHLLCQNARTYNEDGSILFQDANDIEAKCLAELQKETEGYPQFANYDDLGGQGGNDQSTAAASGADTPSAVATPKLKLTFNSGNRDNAAAAGAGNGVNETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM52</accession>
    <name>A0A8G1VM52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_522209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513280.1">
        <property type="nucleotide sequence ID" value="XM_025665244.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A8G1VM52"/>
    <dbReference type="GeneID" id="37168646"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF50">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH55358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="36374" checksum="B3DF3E1171F1E019" modified="2022-01-19" version="1">MPSTVESEDQTYVLSHRSKQTEEHERLNRQHNLIQQTFLNNQLVHPSIPLSALKGGVADIGCGTGIWLREVAQSLSSPGLENGTGAFTSPATTPLPSLVGFDLNAAAFPETPTPGIQLVQHDCTKPFDPRYHGQFNLVNIRGLAYAITEEKLSRALENALQLLKPGGYLQWTESEARLFRLFPETPEMLKALEIIDLERRARDLVPYLPHFMLQRILSLKNSNGDDALNILHFNLRPGGFCQEDGDPEVCLEFSDHLTDSVNLFLHSALMRMEQQQSQNGSAVENGNTGETKLDELRKLKTSVSETIEAKRVRMGGIFPHLVAQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMH2</accession>
    <name>A0A8G1VMH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_396222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515677.1">
        <property type="nucleotide sequence ID" value="XM_025656989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMH2"/>
    <dbReference type="GeneID" id="37160391"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF35">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH57755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="282" mass="31537" checksum="404C20D9FEFEE4F4" modified="2022-01-19" version="1">MATGWTAYAYYPSVGGAVVMIMLFLIGVIIFTYQLIRTRAWLTIAALIGGMFETVGYIGRAMSGNQSPNWTLGPYIIQSTLLLIAPALFAATIYMILGRIIALVHGEHHSIIRLKWLTKIFVVGDCLSFLMQSSGAGIMVQSKSATDNTGENVIIGGLLVQIIFFCFFLVVAIIFQRRIYRHPTVRSESPMIPWRKHFFSLYASSFLILIRSIVRFIEYIQGQEGYVITHEAFIYVFDAVPMFLVLCILIRFHPSEINGLLGKSRVAAVGYGLRFVDVSPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMT7</accession>
    <name>A0A8G1VMT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SMAD/FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_375362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513955.1">
        <property type="nucleotide sequence ID" value="XM_025656167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMT7"/>
    <dbReference type="GeneID" id="37159569"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000038">
        <property type="entry name" value="FHA domain-containing protein SNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="67"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="161" mass="18248" checksum="DA439EEB79067110" modified="2022-01-19" version="1" fragment="single">KEKPNFGQTGRLAAESKTVNVNGNSVVLKYHEPPEARKPPAKEPWRLYVFKGQDLLEMVELGIRSCWLVGKEQLVVDFPLEHPSCSKQHAALQFRFVEKRNEFGDRIGRVKPYLIDLESANGTTVNGDAIPAGRYVELRDKDVIKFGLSTREYVLMLPPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNC8</accession>
    <name>A0A8G1VNC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_419134</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516369.1">
        <property type="nucleotide sequence ID" value="XM_025657844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNC8"/>
    <dbReference type="GeneID" id="37161246"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR ASQA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="225"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="565"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH58447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="641" mass="72049" checksum="D9BCB754DF35C61C" modified="2022-01-19" version="1">MDVSRSSLHVTPRASVTKGRQTPSGGMTPCPDDTETAPINYRLDSTLGFIDRINTFCAGVSQLSSRWSPAGPPPAYSSPFTPHDTDGTAAIECDLSSAQVNRVLEIFWARLFPQVPIVRQEDLECPPSHEDTATGSHPQPLRDAVTAYTMQYIFYSGLNARLLGLQWKQFNSSNRCSKKIGMPYFQRCLTGAMQYSTFAKPSLPNLQCYCIMTLYLLDAGQHQAAYNMIGLAVRIARSLDLDCDPPPQASREQAELHSRIWWTLVHLDFRCSRHLGKPISVQLPISRSPPPCWMSNDPPRQVWFPYHNESIRLTCAALAVIESMAHHEKTRKTHDIGFQANVLTDNLHHLRVWKDELRQNTWFKHLQLDVQDVPISRKYFCGPGENGSGEEYNDYMIKTPLQIQTEAPLELQYHDAMISLHRVFIQFPRQPAMNRENPLAGAHAATALKHALATIQTVYSCMTAHDIFYGSCELYQYQWNAVLTLMGFMLAFPFCPRCPQARGYVDLALETFEFAGYQNDAAVRAACLTRHLCEKVDKLTMMLNIDLRRGVTESTKDVPAPTKDGLTQQANQQSGSVNTNIDADSTNIDHSLLSLAQNQAGDDLFWPWADLVDPDIWPSYCDGVNEAFADISHLPTMTNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNM1</accession>
    <name>A0A8G1VNM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_417920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516862.1">
        <property type="nucleotide sequence ID" value="XM_025657788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNM1"/>
    <dbReference type="GeneID" id="37161190"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH58940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="704" mass="78651" checksum="1C4370617A1E5C80" modified="2022-01-19" version="1">MPRPKVRPEDRRRSSHACQTCKILKIRCDSQHPCSSCMRRGQAHTCAYSGMDRRKRRTGDGVQNTHSRVTDRQDGFSQSNRVTAAENENTPFEFETLVSEMVTPESRSDDTRPPETSLRERLSLAPEQSTKVDVGETSAMSFLHFLRKIVKAYVGSVPFTDAERHHIIIATDLCSTTEDDQNIEPKRIHSYLEYYYEATSGILDLFTAQEVETLLEAHTSSRQPISTAAVRQEDVAAIGVALSIGAQVRGSDRDSQVANEYFRRARQAAFNDMLMGQNVGTVRLFLLMAFYMLGACNRNAASMFLGVAARAAIILELHSIEGYDSTLSKEDYESRRRIWHSMRNLDILSSFVLSRPRSLPLVQSMSDTDELNSHSAFYAIGNGCTLLINIVDTLSNGGLLDVPTAEGLLSQLRKWSSDLPASLRQFRSVSHGLQFLEPADRQRLVGSIHVSCLYYFAVILVTRPYLIAYLVSRLRGKAPDHLISDPDEASDVAIKNNKVSKLAQVCICVDGQSRRDSFSETFVSSSMPPFTSSLSWIFGAGLILGFSMFAGEPRRDIQSLFNSTLHLLDDIGRTSPQAQLYHQILTSFNDAVTKFRNRVAGEVYRTVQDYMDQILAIDPTVDGGSTAHARDREDSYTVWNDDWLAGAIRSAETGEVALDPVLNGTQGAQMFPDPGDWGDIDGMELEEDLLMDIDPFDQFFFTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNQ2</accession>
    <name>A0A8G1VNQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartokinase</fullName>
            <ecNumber evidence="8">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_399417</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="8"/>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514855.1">
        <property type="nucleotide sequence ID" value="XM_025657095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNQ2"/>
    <dbReference type="GeneID" id="37160497"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04247">
        <property type="entry name" value="AAK_AK-Hom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04934">
        <property type="entry name" value="ACT_AK-Hom3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000029">
        <property type="entry name" value="Aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000033">
        <property type="entry name" value="Aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000001">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041747">
        <property type="entry name" value="AK-Hom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="462"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH56933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="525" mass="58036" checksum="DD26C7FCB8FA714A" modified="2022-01-19" version="1">MDDHQQNQKDPLEVARYESKDSPDSNWVVQKFGGTSVGKFALNIIDQVVLPSLLEHRVAIVCSARSSSTKAAGTTNRLLRAARDAEDALSQEYASLVEAVRLEHIQVVDEQIQSKVLKSRLISEINNECDKVLRVLEAAQTLGEISARCVDKVISTGEKLSCRLMAAYIQDRGVDSQYVDLAEVIDFPISNQGLDQDFYNNLAAALGRKIRACENKVPVVTGFFGTVPGGLLDQIGRGYTDLCAALVAVGIDAKELQVWKEVDGIFTADPRKVPTARLLPAITPAEAAELTFYGSEVIHPFTMEQVIRAKIPIRIKNVMNPRGDGTVIFPDSTFELEKTTPGHDPRLFRTRSPSLVQRPKRPTAVTIKHKILVINVHSNKRSLSHGFFAGIFSVLDRWRLSIDLISTSEVHVSMALHSEMPLLNGVGRDEYQVIDEDLKGALRDLQRYGTVDIIPEMAILSLVGKQMKNMIGVAGRMFSTLGENNVNIEMISQGASEINISCVIEERDADRALNIIHTSMFTFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP33</accession>
    <name>A0A8G1VP33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 11">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_447131</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 11"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518481.1">
        <property type="nucleotide sequence ID" value="XM_025659655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP33"/>
    <dbReference type="GeneID" id="37163057"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.960:FF:000002">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000004">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="515"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH60559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="668" mass="76113" checksum="A3E45995760B3BB0" modified="2022-01-19" version="1">MGLLALGTALDWPEAKKRADQVRKWGIEQLLANWHRAKGKERNALLWGDEVEYLVVAVDDESKKARLSLAQADILKSLAEDEASWKEGTSLLSQNKEHEGEEPPHFHPEFGRFMLEATPGKPWGIDFKDLLKVESNMKWRREVAKAHMAPNESPITLTTFPRLGTKDDYIQPYYPPSGPALRSQFVPDEIANPHIRFPTLAANIRSRRGRKIELNVPVYKDKNTPDPFLDPTVDYDLHNWPEDDDVRNGAAKEGHVYMDAMAFGMGSCCLQITFQAKNMTEGRKLYDQLSPLGPILLALTAATPIYKGFLVDTDVRWNQISGAVDDRTREELGELPLKNDRWRIPKSRYASNSTYISQDPRLRKEYLDPDLIVDQDIKKRLMDDGMDDLLATHFAHLFIRDPLVIFSEDLEELDLNKADHFENLQSTNWQHMRFKPPPPDKDDIGWRVEFRSMEIQMTDFENAAFSIFIVLVTRAILSFDLNFYIPIQRTTENMETAHLRNAVLEQKFYFRKDPFSRRRPNQQSPGGSNVSSTTSSAHNTPPPSPPLSPVESEYDLMTISDIINGSPDGSFPGLIPLVESYLNSVNVDVETRCSLASYLDLIRKRANGTLWTGAKWIREFVASHPGYKHDSAVSEEICYDLVKAVDEMTVKEGKHGTVGWELLRGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP67</accession>
    <name>A0A8G1VP67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_510316</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517447.1">
        <property type="nucleotide sequence ID" value="XM_025664545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP67"/>
    <dbReference type="GeneID" id="37167947"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="246"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH59525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="644" mass="72703" checksum="1F7C087B2EBFDE95" modified="2022-01-19" version="1">MRPRVSRIAGLSERLSTLEHVVSYPSNAAATSSRSYARSQAWESNSTRTDQPISSHVPETVIWNLNSVKRETPCQRVSESPAVSEDTPIHQVSEARRSIQQELQNSNHLSPQRRTVLENALLLVNKISASSTEPKVSSGNPRCADDHDASVREEFSLELYLMMSMDISHQHSAQRHFYWPDHISSKCLEHMSLSLAEGKLDRQTSLHYQVCVYTKALFFLARVPQQRLGPRLRTHVKKTQERYASAALRALDQINFIGTYSITLVQALLSAALLHQMQGYPTRGWTLTAFASQILVAMNYHTIRDDTPVRCQEDQDARFCLFSCFYLDKMLSMLLLRPPSLPRLKLNPASLIPMESGALSLIVKTMVELAQIQEAAMDVVHRNHGLSDISDVDTTLDAAIQNLASLRGVIDERCRDSSPALQVEWIATEFRYHAIMATLLHLSPRVQAQPQAREECLEQARHAFQALRRIHKLLNEDDCFVVLITRTVLSYPMTPFYLLFCNVVGTSNTEDYQLMHETTRGLHRFIDTNPPISKLYHLFTTFLNLCSPLMQGDGSVNTMAMPLDETNLTTMPSSSGAEVSIPQVDADNYIYDSATRSGIVDDGAIDPNMVSNWNNAQMWELFGVQPSLEWVDSEVSHVIPERYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPB8</accession>
    <name>A0A8G1VPB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_368142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517419.1">
        <property type="nucleotide sequence ID" value="XM_025655851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPB8"/>
    <dbReference type="GeneID" id="37159253"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="390" mass="43448" checksum="388BE8AD5F16A68F" modified="2022-01-19" version="1">MEQTQAQPSSSNLKSSPEQSSPPGPAECLTNADEAPNPAASLSEEEDNVSETEHLAVLSRKKGYAHGVEEYQRFVNAGGGTWMISFQEIGERFYKLAMRVVGWMGNWGYCVQEDLTVLQGLLPPRRSLADHFAEALIHKAIMENVFSNSFQYLDGKTSSTDQAEDKRFASKLQYLYKRFFDTNPNLATLWKEQTHRLANSTDPVKAPGDLSFGRDNAKRLLACAPSLADEMLASEPIGLLLKKRLGRNQVAKRRKELIEIFEASLGLMKLCETGVGGHFKMKRLSELGPLYQCGSSYMIFNLCNGDIVDERDFEGRKILLVVRPTIMYTDSAPSELNSPYKSMAAIISKASVVLDKGGEAKESTTAERRIIMRATRFKEGEVCVNTSEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPG9</accession>
    <name>A0A8G1VPG9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
            <ecNumber evidence="12">1.1.1.330</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">3-ketoacyl-CoA reductase</fullName>
            <shortName evidence="12">3-ketoreductase</shortName>
            <shortName evidence="12">KAR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Microsomal beta-keto-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_457900</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="EC" id="1.1.1.330"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.330" evidence="12"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517747.1">
        <property type="nucleotide sequence ID" value="XM_025661547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPG9"/>
    <dbReference type="GeneID" id="37164949"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045703">
        <property type="term" value="F:ketoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141040">
        <property type="term" value="F:very-long-chain 3-oxoacyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000317">
        <property type="entry name" value="Very-long-chain 3-oxoacyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03107">
        <property type="entry name" value="3_ketoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027533">
        <property type="entry name" value="3_ketoreductase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH59825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="346" mass="37661" checksum="B3611A57181505EB" modified="2022-01-19" version="1">MEFLTKHLDCLSNFQLNLQPGWQTVGASALLAAGSLFVVSRALVFVRVLLSLFVLPGKPLRSFGPKGSWAVVTGASDGLGKEFALQLARADFNILLVSRTASKLDTLSNEITSKFPSVQTKTLAMDFARNDDSDYEKLKELVDELDVSVLVNNVGKSHSIPTPFALTPEDEMTDIVTINCLGTLRATQLVVPGMMQRKRGLVLTMGSFGGLLPTPLLATYSGSKAFLQQWSTSLGSELEPYGITVELVQAYLITSAMSKIRRTSATIPDPRSFVKSVLTKIGRNGGSPTYAYSSSPYWSHGLMAWFLTCVTGTMGKIVVGQNKGMHESIRKRALRKAEREKGKKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPK3</accession>
    <name>A0A8G1VPK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coupling of ubiquitin conjugation to ER degradation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_486240</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CUE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517704.1">
        <property type="nucleotide sequence ID" value="XM_025663375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPK3"/>
    <dbReference type="GeneID" id="37166777"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14424">
        <property type="entry name" value="CUE_Cue1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000050">
        <property type="entry name" value="Related to AMFR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="12">
        <location>
            <begin position="48"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="139"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH59782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="192" mass="21174" checksum="660D1C7EF4532DA1" modified="2022-01-19" version="1">MPEEEPSLNIPSLLTLAVVSFFVLRWFLNRDGGEAGPGSSRSRPRGTVDPAQVEQISQMFPQLSAREIMWDLQRNGGSVAATTERILTGRGLEVPPPSFQPQIAIPNTAPVQSQPTQTATSKADAQDLISRYNLRAKLEAENSAAESAPSQASSTTGWSQSKEERQRLLQKRRDEMILAARRKMMQKDQAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPN2</accession>
    <name>A0A8G1VPN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Aurora kinase</fullName>
            <ecNumber evidence="1 15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_468546</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 15"/>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515815.1">
        <property type="nucleotide sequence ID" value="XM_025662270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPN2"/>
    <dbReference type="GeneID" id="37165672"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="119"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="197"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH57893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="396" mass="44773" checksum="45F6589FF5D7AF67" modified="2022-01-19" version="1">MASKTLEARLERLSVKDENDSGHNGGGYPKPKSSLSTAMSLSGLGAAGQYSGSNRSNLLKLALQNTNDNKVNAMNVAQSPTKGSQNTLPSRNLDENGEQRHPNPLYEQPAPKKLHLGMFEIGKPLGKGKFGRVYLAKERSSGFVCALKVLHKSELQQGGVQKQVRREIEIQSNLRHPNVLRLYGHFHDSKRIFLILEFAGRGELYKHLRKEHRFPEWKAAQYIAQMAAALKYLHKKHVMHRDIKPENILVGIHGEIKISDFGWSVHAPNNRRQTMCGTLDYLPPEMLKPGSQDNYYNEKVDLWSLGVLTYEFLVGEAPFEDTPVMTQRRIARADMSVPSFVSPEARDLIKRLLVLDPEKRISLDEIQRHPWILKHCVKDERTVKRSSGSASTKDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ05</accession>
    <name>A0A8G1VQ05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate synthase</fullName>
                <shortName evidence="21">DHQS</shortName>
                <ecNumber evidence="21">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="21">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="21">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="21">EPSP synthase</shortName>
                <shortName evidence="21">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate kinase</fullName>
                <shortName evidence="21">SK</shortName>
                <ecNumber evidence="21">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="21">3-dehydroquinase</shortName>
                <ecNumber evidence="21">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="21">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="28" type="ORF">BO85DRAFT_194778</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20 21 22">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 21 22">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21 22">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21 22">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21 22">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 21 22">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the N-terminal section; belongs to the dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="21"/>
    <dbReference type="EC" id="2.5.1.19" evidence="21"/>
    <dbReference type="EC" id="2.7.1.71" evidence="21"/>
    <dbReference type="EC" id="4.2.1.10" evidence="21"/>
    <dbReference type="EC" id="1.1.1.25" evidence="21"/>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519278.1">
        <property type="nucleotide sequence ID" value="XM_025654464.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37157866"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00054455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR000514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="RAH61356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1586" mass="172276" checksum="AA2879C4B201A23D" modified="2022-01-19" version="1">MSEPTKISILGRESIVADFGLWRNYVAKDLINGLSSTTYVLVTDTNIGSLYTPSFQKAFEQAAAAVSPKPRLLVYHAAPGEVSKSRQTKADIEDWMLSQSPPCGRDTVVIALGGGVIGDLTGFVASTYMRGVRYVQVPTTLLAMVDSSIGGKTAIDTPLGKNLIGAIWQPSRIYIDLEFLETLPVREFINGMAEVIKTAAISSEEEFTALEDNAETILSAVRRVVQPGQRRFEGIEDILKARILASARHKAYVVSADEREGGLRNLLNWGHSIGHAIEAILTPQVLHGECVAIGMVKEAELARHLGILKGVAVARIVKCLSAYGLPTSLKDARIKKLTAGKHCSVDQLLFNMALDKKNDGPKKKVVLLSAIGRTYEPRASVVPNEDISVVLAPSIEVYPGVATSSNVVCTPPGSKSISNRALVLAALGSGTCRIKNLLHSDDTEVMLNALERLGACTFSWEEEGEVLVVNGKGGDLQATSHPLYLGNAGTASRFLTTVATLATPTDVDSNVLTGNNRMKQRPIGDLVDALTANGASVEYMERKGSLPLKIAASGGFAGGQINLAAKVSSQYVSSLLMCAPYAKEPVTLKLVGGKPISQPYIDMTTAMMRSFGIDVKKSTTEEHTYHIPQGRYVNPAEYMVESDASSATYPLAIAAITGTTCTVPNIGSKSLQGDARFAVDVLRPMGCTVEQTDSSTTVTGAPGGVLRPLPNVDMEPMTDAFLTASVLAAVARGDGSNHTTRIYGIANQRVKECNRIKAMKDELAKFGVICREHDDGIEIDGIDRTSLRQPAGGVFCYDDHRVAFSFSVLSLVTPQSTLILERECVGKTWPGWWDSLKQLFSVKLEGKELKEDEAAALTQAEKSSASIFIIGMRGAGKTTSGQWVAKTLNRPFLDLDTELEATEGMSIPDIIKQRGWQGFRDAELGLLQRTLKERSTGYVFACGGGIVEIPEARKLLIDYHKTKGNVLLIMRDIKQVMDFLSIDKTRPAYVEDMMGVWLRRKPWFQECSNIQYYSQTAASGGLARASEDFKRFLRTVTGEVDSLSTIKRKEHSFFVSLTLPDLRNASDILKKVCVGSDAVELRVDLLEDPTMDGDIPSVDYVAEQLSFLRSHVTLPVIYTIRTKSQGGRFPDDAHAEALELYRLAFRSGLEFVDLEIAFPDEMLRTVTEQKGYSRIIASHHDPKGELSWSNMSWTKYYNRALEYGDVIKLVGVAKNLDDNNALRNFKNWAASAHDVPLIAINMGDNGQLSRILNGFMTPVSHPSLPFKAAPGQLSAAEIRRGLSLMGEIQPKKFAIFGTPISQSRSPALHNTLFAQSGLPHEYSRLETANAEDVKDFIRSPNFGGASVTIPLKLDIMPLLDEIAPDAEIIGAVNTIVPVSQGKGQPARLVGYNTDWQGMTLSLRNAGVYGCNGDASAVVVGGGGTARAAIYSLHNMGYSPIYIIGRTPAKLESMVQTFPSSYNIRIVDTIDALDTIPKVAIGTIPADKPIDSGMRETLCHMFARAQEIDADMVKSVEKVPRVLVEMAYKPSVTTLMQLANDAGWHTVPGLEVLVGQGWYQYQRWTGISPLYDDAREAVIGSPDPNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ57</accession>
    <name>A0A8G1VQ57_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_446969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518334.1">
        <property type="nucleotide sequence ID" value="XM_025659618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ57"/>
    <dbReference type="GeneID" id="37163020"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034349623" evidence="1">
        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="80" mass="8275" checksum="BDB6BED97E4821D0" modified="2022-01-19" version="1">MPTFINNGIAALRAVLSVSILTLSPAACASLYARILTSIAPTVPVCTLLPSGRVTSGIAVPSVDEFKATRLAADELDMMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQM5</accession>
    <name>A0A8G1VQM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_445393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519908.1">
        <property type="nucleotide sequence ID" value="XM_025659251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQM5"/>
    <dbReference type="GeneID" id="37162653"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="294"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="389" mass="44272" checksum="C8B773C152C6EB58" modified="2022-01-19" version="1">MPTFSRKPRKPRARMKTGGTWTDEEKQRFWDQRTMYSRMPWREFRKQFFPHRSQNALEKAYSMMSIERRREANISNPDTPRNPPPARIVTLRTRTNKRALPDEMAPGNRPGKQTRTAAVLSSGKDQVEETDQNNMTDEDTSSDYEQDSDEETLQGPSLPYEREGLEGIETIVIDDTNNAPENRQSGEEEAGVGRTDAQGDTDMPDSRPNGSTGVSSNKTPPAGSIPGRTSMTPSSRSGENQQGHQRSTKEATEPTRPSLPSDVQYLKNLIWRFETTFFKNYDQEKVIASLQCQVEDLKKINSDKTAKLESAQEESRRHTQTIKSLEQRELKYRKEIYDLKNKLVLSDQRATIFERKVAVARSMNKCETCLRVAKIVNADADESSNGPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRG5</accession>
    <name>A0A8G1VRG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase I-specific transcription initiation factor rrn11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_447619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517675.1">
        <property type="nucleotide sequence ID" value="XM_025659756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRG5"/>
    <dbReference type="GeneID" id="37163158"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053029">
        <property type="entry name" value="RNA_pol_I-specific_init_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007224">
        <property type="entry name" value="TIF_Rrn11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04090">
        <property type="entry name" value="Rrn11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="49657" checksum="E88D64634EDC78D3" modified="2022-01-19" version="1">MASVPAAAVFSLPLAPWQQPASVRVAQYEPRKRKKDFSDWGDDDDDVDGDTTDAASEAAPGPSLTLSPDEAHQYRIAGLAFNQELPGGNFPHAPVKDQPTRRQTRNQVLKELTSLPSPIYPPQSAAHQGNLRLQHLAVLSSILHRCLLQKDFVRAGRAWGLILREEIGGIPIDVRTEGRWGIGAEILLRRDCQVSDTSPDNAQERDAEPSEAPPSKLLFTRQGFEKAKQYYETLIIQHPYRKAAPDAISSLHFYPAMFGLWVYVTQEESNVCRQKIWDAHGASPDDSEGEDSALDIQHHDVTRQKTHALIASVRKSELEQAQKIAARMDEILGSPPYSDSPELLELRGMISLWIADLFVSSLPYGRAEGDMDDYDSDETGSSSAEDLQDSLQERRERRLAVERKEYEVQKSQDYFAKAKQRGKGVTSTFGDLHIDDDDASFGYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRN4</accession>
    <name>A0A8G1VRN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5'-3' DNA helicase ZGRF1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_465162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521181.1">
        <property type="nucleotide sequence ID" value="XM_025662037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRN4"/>
    <dbReference type="GeneID" id="37165439"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052800">
        <property type="entry name" value="DNA_Repair_Helicase_ZGRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018838">
        <property type="entry name" value="ZGRF1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28535:SF1">
        <property type="entry name" value="PROTEIN ZGRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28535">
        <property type="entry name" value="ZINC FINGER GRF-TYPE CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10382">
        <property type="entry name" value="ZGRF1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' DNA helicase ZGRF1-like N-terminal" evidence="2">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="482" mass="53924" checksum="C9837FDD61D707ED" modified="2022-01-19" version="1">MATPRSTPSMNVPATQNTAPVIRFRCLYTYDMRRKAKRWQDGFLRYHTFNKRIMVYDVAGNFVGDHHCRQDEGIQEGDELELDNGALIEVCEPVERTETDLSGLHSNKRKGQGSPSQRPGGTPTPTTVVYNSSTPARPSLPSQQKPTRSLNDLLGIKKTPTPTQRAGSPQTGPTSNHTLPVNGNENERVDYPAKRKKTETASEKVTRRREPANADLTGPEPQTSKRQTETTSVAHSRTTDPKKHTTASPISYMKSPDRSNNIPQRKQTAPNPPRPREQPQPEPEPEPPRNNDPPANILRLPSKTKPSRKKLMYHTILAQQQQQQPQPQSENDHDNDPIVLSDDDDNDNNPPPSPPPRPQHTTTTTIPTTTTPKPPLPLKAGTERRTSTSSLQKAHSDPTAFTRFNLTTNTTTNNARRPPPQQHHNHRRRASESGNSPLDTTDNENTNEEEPESDGGGPWTWEAQYLFDYWPAGRAKPTTRTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRQ3</accession>
    <name>A0A8G1VRQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arylsulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_413154</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520072.1">
        <property type="nucleotide sequence ID" value="XM_025657595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRQ3"/>
    <dbReference type="GeneID" id="37160997"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16025">
        <property type="entry name" value="PAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000044">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.10:FF:000005">
        <property type="entry name" value="Arylsulfatase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF46">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH62150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="613" mass="69267" checksum="D4259A0C90798ED8" modified="2022-01-19" version="1">MAPKRPNFLVVVADDLGFSDIGCFGGEIRTPNLNRLAQEGVRFTDFHAAAACSPTRAMIMTGTDHHIAGLGNLVEWTNISGQNDPKGGGMSTAPQRGMPGYEGYLNERVVALPEVLRDGGYHTLMAGKWHLGLTPERSPYRRGFDRSLAHLPACSNHYAFEPQLQGTDETPTFLEASYIALHTEDDQYVKKLPDGWYSSDGYGDKMRDYLKDWHERGDDRPFFAYLPFTAPHWPLQAPREYIDHYRGVYDEGPDVLRQRRLERLKALGMIPDSVEPHPVVAEEDEAKPWSELSPEEQKMSSTAMEVFAGMVECIDANVGKVVDYLASIDELDNTFVCFMSDNGAEGAAYEAYPLVKSGVLPHLQKYYDNSLENLGNYNSFIWYGPRWAQAATAPSRLYKAYTTEGGVRVPFLARFPTSVQTSPHVQAGAITDQFATVMDLAPTILDMAGLKHPAPTYQGREIVPMRGKSIYPWANGSAARIHPEDFIQGWETCGRAALRYGDWKIVYIPKPKGPERWQLYNLRNDPGEVHDLAENEPERMKVLLKLWDQYVLETGVIPLSPDLGEFLEAMDEQMKENVWMEFDYWKKGAREEPDKYTRKPLRFGGLQKTVKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRT0</accession>
    <name>A0A8G1VRT0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_515775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521168.1">
        <property type="nucleotide sequence ID" value="XM_025664807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRT0"/>
    <dbReference type="GeneID" id="37168209"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034756290" evidence="3">
        <location>
            <begin position="19"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH63246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="386" mass="42812" checksum="EAD1216C410DBD7B" modified="2022-01-19" version="1">MHLRSCLVGSVLALGANAFLVIPEVEEAVAPEGDFPPLHPLEVYAPKKEQVELACTECPFREVSEDGKVSWTDGFQTSLLVDFSTENGFLLANGRQIFPPPPPTLITAVQRRASDGVETEPIPLGYAVEEMPLPTPPEDPMDLVAVRFTVLDLDSRPVPLDTVALTLLHDPSSGELYIAKAEIEEATPDRVSWKQCRGKPKCLRKLLFDRMRALFAAAKARMLGMAPKPKGCGGPHGLGLPPPPRPHHHHHHHPDDKFDPERMPPMEGEEAGFHGHMDKFDRPHHHHHMHHMHHGQWERTVHRVVRFIVVPAVLGVLAGLAASALGMLVGQIVVFMWQRFRRSTPKKSLEQGTVSEKQGLMMESEELPPAYSDEEPVAEEVSSAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRV7</accession>
    <name>A0A8G1VRV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_21367</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521243.1">
        <property type="nucleotide sequence ID" value="XM_025654629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRV7"/>
    <dbReference type="GeneID" id="37158031"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH63321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="465" mass="51330" checksum="A7DD5EF0C0A5A448" modified="2022-01-19" version="1">MSFSLPIRPTTRHASRLAQVKIRSGRFYSTESDLKTALKSVIPEKRELFKQVKARSDDMVGEVKVGNIIGGMRGLKSMLWEGSVLDPEEGIRFHGKTIKNCQRELPKGTTGTEMLPEAMFWLLLTGQVPTTSQVRAFSRELAEKSHLPDHILGLIKSFPKDMHPMTQLSVAVAALNTESTFAKAYERGLNKADYWEPTFDDSISLLAKIPRVAALVFRPNEIDQVGTQALDATQDWSHNFAELLGKGGAEHSDFHDLLRLYLALHGDHEGGNVSAHATHLVGSALSDPFLSYSAGLLGLAGPLHGLAAQEVLRWILAMQEKIGTQVTDESVRTYLWDTLKSGRVVPGYGHGVLRKPDPRFEALMDFAATRADVQANPVFQLVKKNSEIAPEVLTQHGKTKNPHPNVDAASGVLFYHYGFQQPLYYTVTFGVSRALGPLVQLIWDRALGLPIERPKSINLKGLVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQF7</accession>
    <name>A0A8G1QQF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="6">M1Pi</shortName>
            <shortName evidence="6">MTR-1-P isomerase</shortName>
            <ecNumber evidence="6">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MRI1</name>
        <name evidence="7" type="ORF">BO85DRAFT_443583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="6"/>
    <dbReference type="EMBL" id="KZ825090">
        <property type="protein sequence ID" value="RAH51928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQF7"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000002">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000010">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH51928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="382" mass="40640" checksum="E651AA8B4B529CF0" modified="2022-01-19" version="1">MTLQAIRYNEGNLSIIDQLQLPYVEQYITIKSSEEAWHAIKDMRVRGAPAIAIVAALALASELHGLMACNGIPSEAPEVQAFIMDKLDYLVSSRPTAVNLADAARKLRAVASDHTQRPGSTGRSVATALIQAAEEMLVKDIEDNKNIGKHGAQWIMANAVGKPKATVLTHCNTGSLATSGYGTALGVIRALASTDNLNRAYCTETRPYNQGSRLTAFELVHDRLPATLITDSMAAALLAKSGTQVDAIVVGADRVAANGDTANKIGTYGLAVLARYHGVKFLVAAPLTTIDLATPSGHEIIIEERAASEVTTVRGPRANKSTNGIELETVRIAADGIDVWNPAFDVTPSTLIDGIITEKGVAEKDADGQFHLEDLFRNSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQN8</accession>
    <name>A0A8G1QQN8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glucan endo-1,3-alpha-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_508398</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Endohydrolysis of (1-&gt;3)-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran.</text>
            <dbReference type="EC" id="3.2.1.59"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 71 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.59" evidence="5"/>
    <dbReference type="EMBL" id="KZ825089">
        <property type="protein sequence ID" value="RAH52048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509970.1">
        <property type="nucleotide sequence ID" value="XM_025664467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQN8"/>
    <dbReference type="GeneID" id="37167869"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990819">
        <property type="term" value="C:mating projection actin fusion focus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904541">
        <property type="term" value="P:fungal-type cell wall disassembly involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000268">
        <property type="entry name" value="Glucan endo-1,3-alpha-glucosidase agn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034686990" description="glucan endo-1,3-alpha-glucosidase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00052604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="460" mass="50120" checksum="91657B545F91AEA6" modified="2022-01-19" version="1">MMLAKSLVVLAAIAASILNPVLGAPALDVGLTEPQSEPKYVFAHFMVGIVENYQLKDWITDMKAAQAIGIDAFALNCASIDKYTPTQLALAYQAAQQVNFKVFISFDFAYWSNGDTAKITAYMQQYASHPAQMQYRGGAVVSTFVGDSFNWSPVKQATSHPLHAVPNLQDPAASSSNAQRGADGAFSWYAWPTDGGNSIIKGPMTTIWDDRFIKDLAGTTYMAPVSPWFATHFNSKNWVFICENLPTLRWEQMLTMKPSLVEIISWNDYGESHYIGPYSANHSDDGSSKWAKGMPHDAWRDLYKPYIAAYKAGDSKPTINQEGLVYWYRPTPKGVNCPEDSMPAPNGFQMLSDSIFVATMLNSPATLTVTSGSNGPVKVDVPAGIVTTNVTMGIGAQTFQVSRNGQVILSGKGGLDVADRSKYYNFNVFVGSVMGSSAAGNASVRLENAIDFAHDLPRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRH1</accession>
    <name>A0A8G1QRH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_431900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510191.1">
        <property type="nucleotide sequence ID" value="XM_025658351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRH1"/>
    <dbReference type="GeneID" id="37161753"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH52269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="355" mass="38891" checksum="74DBC6582A5451E7" modified="2022-01-19" version="1">MTISGTSAIPHGSRVLVTGANSLVGSNVADRLLSRGYRVRGTVRSAQRHQWLGDLFRGKYGKDSFELVQVQDIQRPGAFDEAMKGVSGVAHVVTIFAGPNDGPDEVFESIKQLDHNVLASAAAEPSVKRFVYTSSCQAANTMGLDDLDGKTVITSETWNKTAIQRAKTGSPAEWRRGFDIYSASKALGEQGIWEWVREHKPGFVVNTVLPSLCYGASLDPENQGFPSTLSWPAAIIRNDWASVSEHVKANLPNGGYCVGIEDAALLHVAALTNPTVQNERLFAYGWPFFWNDLATIYRTIFPNRELPTDLPARDKDADLLDVKPSRRSEDLLKEMGKPGWSSLKEIIVANAYGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRN0</accession>
    <name>A0A8G1QRN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_493105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825085">
        <property type="protein sequence ID" value="RAH52383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510305.1">
        <property type="nucleotide sequence ID" value="XM_025663813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRN0"/>
    <dbReference type="GeneID" id="37167215"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11318">
        <property type="entry name" value="AmyAc_bac_fung_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000024">
        <property type="entry name" value="Cytoplasmic alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013776">
        <property type="entry name" value="A-amylase_thermo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015237">
        <property type="entry name" value="Alpha-amylase_C_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006968">
        <property type="entry name" value="PRK09441.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006969">
        <property type="entry name" value="PRK09441.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09154">
        <property type="entry name" value="Alpha-amy_C_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001021">
        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="41"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH52383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="548" mass="62935" checksum="719CD1B6A0DF801A" modified="2022-01-19" version="1">MLSFLLCCHPKKRRERQIWKQIEEEAEHLDQLPSWDAPDNTLMLQAFEWHVPADQGHWRRLHQALPSFKAIGVDNIWIPPGCKAMNPSGNGYDIYDLYDLGEFEQKGSRATKWGTKEELQSLVAAAQDLCIGIYWDAVLNHKAGADYTERFEAVRVDPQERNMEIAPAEEIEGWVGFNFSGRDDQYSSMKYNKHHFSGIDWDQLRQRREVYKIQGHEWANDVAHENGNYDYLMFANLDYSNAEVRRDVLNWAEWLNSQLPLSGMRLDAVKHYSAGFQKELIDHLRAIAGPDYVIVGEYWKGETRPLVEYLKQMDYKLSLFDSALVGRFSSISQTPEADLRNIFSDTLVQQYPDHSVTFVANHDTQPGQSLEAPVTSFFKPLAYALILLREQGQPCIFYGDLYGLQADVKDPMTPSCRGKLPILARARKLYAYGLQRDYFDKPNCIGFVRYGNRRHPSGLACVMSNTGPSRKRMYVGRRHAKETWTDILQWCDQTVVIDPKGYGEFPVSAMSVSVWVNSEAEGRDSLSYHLYVFACSLSIDDVLTSTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS03</accession>
    <name>A0A8G1QS03_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_453863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510461.1">
        <property type="nucleotide sequence ID" value="XM_025661150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QS03"/>
    <dbReference type="GeneID" id="37164552"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="85" mass="9813" checksum="1347E2B0ED4C26C1" modified="2022-01-19" version="1">MLNWHDYDNSFLGGFFSACLQRTILYGLLSRKKNINGITESRGVKNCARLKPTESHTHIFSYQVSLTQGSQSVTEITYPQFSWRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTA6</accession>
    <name>A0A8G1QTA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_508565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509807.1">
        <property type="nucleotide sequence ID" value="XM_025664473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTA6"/>
    <dbReference type="GeneID" id="37167875"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH51885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="173" mass="19159" checksum="AA0D934BD3B89198" modified="2022-01-19" version="1">MGRRSGHRNDPPLIPNQTGGIGETARRRGVEVSRLARQALRPSSGQVQAVSGVKLPWRLPTPKCQQRQAAIPSFSRFANGFELLISQLVNTVCSGVSVYSFSRHLHSHPLPSSCSYFILVGPVVDGVLVVFFAIVYPVQRAVIVAHRPFSPYRLPCSAYDQHPFVCRTNFFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTE8</accession>
    <name>A0A8G1QTE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteasome component Prs3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_408898</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825090">
        <property type="protein sequence ID" value="RAH51945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509867.1">
        <property type="nucleotide sequence ID" value="XM_025657418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTE8"/>
    <dbReference type="GeneID" id="37160820"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03757">
        <property type="entry name" value="proteasome_beta_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000027">
        <property type="entry name" value="Proteasome subunit beta type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH51945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="260" mass="28395" checksum="054B8C9BCBED78D2" modified="2022-01-19" version="1">MTTLAGNPLSEAIGYSFSNANSAPHREHSFYPYTDNGGSTLGITGSDFAILAGDTRSVAGYNINSRYVPKVFKIGGDDESGEGANIVLSVVGFAADGQALKERLDAVVKMYKYQHGKPMSVRACAQRLSTILYQKRFFPYYVHAILAGLDEDGKGALYSYDPVGSYEREQCRAAGSAASLIMPFLDNQVNFKNQYIPGSGEGHALEPKKAEPLPRDTVEQLVRDAFTSAVERHIEVGDGLQMMVITRSGIEEIYYPLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTL4</accession>
    <name>A0A8G1QTL4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_408040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825085">
        <property type="protein sequence ID" value="RAH52349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510271.1">
        <property type="nucleotide sequence ID" value="XM_025657386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTL4"/>
    <dbReference type="GeneID" id="37160788"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29669" checksum="C3997E8F03961AF6" modified="2022-01-19" version="1">MTSHQHLRGSCQCGRNQYQIRLPDDITDHAHVYLDTGRDNRRFHAAPLTAWLRVPLTWYQSHTQSYFPDETHSTIRRIFSPHHAPHTQRVFCGYCGTPLTFWSEDPREEAEYMSVSIGSLFGDGQRMLEDLELLPPESPPHSSDEEREAEEEGAGPAKGKEKVVVSPATAQQDTRSSDVVIPSGSAVSRSYRHGTLGGIPWFEEMVEGSRLGRMMKTRRGVGVSDDQSTSFEWEISEWTSDSTQAAGKRKRGHHTNVEDIEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTS0</accession>
    <name>A0A8G1QTS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Taurine dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_454317</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510032.1">
        <property type="nucleotide sequence ID" value="XM_025661258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTS0"/>
    <dbReference type="GeneID" id="37164660"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="48"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH52110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="372" mass="41685" checksum="449215930CB8655E" modified="2022-01-19" version="1">MAPGLSADLPIHSHPASSGDGPTDQPRYPAPLKPSGALDEFAFEETTPIIGREYPTVNIVDDLLNAPNSDELVRDLAITISQRGVVFFRAQTNLTDDLQKVLVHRLGQLTGKPSTSTLHIHPLLNNTNEFGTADAEISTISSLARKKMFAHDRQPDRRSYDSAQWHSDIQFEPAPADYTSLRLTQLPKTGGDTLWASGYELYDRFSKTYQKFFEGLTATFVGDGFIKAAERNPKEYKIYTQPRGSPLNVGEELVAVHPIVRTNPVTGWKSIFALGPFPKYINELNQNESEELLKKFKSIIVESHDLQVRFKWRNEHDIAIWDNRSAFHTATFDYEGLGERFGHRAVGIGERPYLDPNSKSRAEALAAEGLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUQ8</accession>
    <name>A0A8G1QUQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal small subunit assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_452755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511834.1">
        <property type="nucleotide sequence ID" value="XM_025660902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUQ8"/>
    <dbReference type="GeneID" id="37164304"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12293">
        <property type="entry name" value="dRRM_Rrp7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12950">
        <property type="entry name" value="RRP7_Rrp7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040447">
        <property type="entry name" value="RRM_Rrp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17799">
        <property type="entry name" value="RRM_Rrp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rrp7 RRM-like N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="3">
        <location>
            <begin position="189"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="305" mass="34812" checksum="FE0FE560872C4746" modified="2022-01-19" version="1" fragment="single">MKADLEIAGFSILPLHFPATPAYPKPATHYLYLRAHEPRIPDADTPRSMFIVNIPVDTTETHLRHLFGTQLSAGRIERVEFEAVPTKKKGMQATPQGNIASSKKRKRVTADELQAQLDDVDLPATWDRQLQKSGSHAIVVFADKPSMEASLKAARKAAKKGTEIVWGERVEGDRVPSLGLQRYITHEQLRYPDRAELLRTVNDYMTVFTQVAEARKREEARRAQEPDEDGFITVTSGPKLAEAAHEDEARQLVEKQKEKSKGLEDFYRFQSREKRKEKQNQLLKKFDDDRRKLADMKKRKGKIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUY4</accession>
    <name>A0A8G1QUY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">High-affinity iron transporter FtrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_502786</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512045.1">
        <property type="nucleotide sequence ID" value="XM_025664216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUY4"/>
    <dbReference type="GeneID" id="37167618"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH54123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="367" mass="40483" checksum="F91C4606758EBDBB" modified="2022-01-19" version="1">MANSVFAVTVFFICFRECLESVIIVSVLLSFLKQTLGGEGDVQTLKRLNRHVWLGVALGLFICLCVGGGMIGAFYGLNKDVFTGSEDIWEGIFGFIASIIISIMGAGLLRVSKLQDKWRDKLAQALEEKEKTNIGIYQRFKDWSKKYVMFLLPFVTVLREGLEAVVYVGGVGLGLPATSFPLAVVCGLAAGIAVGYLLYRCGNTASLQYFLIISTCFLYLVSAGLFSRAIWYLQNNAWNNIIGGDASETGSGAGSYDIRQSVWHVNCCNPELGSGGGWGIFNALFGWTNSATYGSVLGYNLYWICIIIAYVCMWYNERYGYIPFFSACMRRIRPKKAASRSSSEGVIEKSKEVDMMPSQIVTREINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVA8</accession>
    <name>A0A8G1QVA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">UDP-glucose:glyco protein glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_407340</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510782.1">
        <property type="nucleotide sequence ID" value="XM_025657360.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37160762"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000065">
        <property type="entry name" value="UDP-glucose:glycoprotein glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034456459" evidence="10">
        <location>
            <begin position="29"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="11">
        <location>
            <begin position="42"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="12">
        <location>
            <begin position="276"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="13">
        <location>
            <begin position="411"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="14">
        <location>
            <begin position="667"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="15">
        <location>
            <begin position="1188"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1456"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1467"/>
            <end position="1486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH52860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1495" mass="167949" checksum="E700FE0B25742B8D" modified="2022-01-19" version="1">MVSGLGNVASWRLASVLIAGLLAIQGRASPSVNVALQASFDSPPYLIELLESAAEENSTSYFPLLDRIADGTFDDAVTDKDLYDRFLEVVREDGHLRTPESLSSFKLSLAMRSASPRITAHYQFYNASVQHSLMAAQDAVCPVWVHSEGKQYCSSTMERAQQDVEGSDDPRELPFDRVFGDPSLPPAILYADIATPMFKEFHQSLSAMAKEGQVSYRVRYRPPQHWTPRPVFVSGYGVELALKRTDYIVIDDRDAEERVTGSIESGKSDATEDDLDDLRPLSSSEVSRLGLNTVGYVLDSDDPFDTLAKLSQDFPKYSARVAAHNVSTELLQDIRSSRLRMLPPGLNVLWINGVQIEPRQVDAFTLLDHLRRERKLIEKFRNLGLSATDAVELLSHPLLGEALARDGPQRYNYRDDIEGGGVIMWLNNLEKDARYESWPSELAGFMQRTYPGQLPAVRRDSNNIVFPVDLTSTEDADIVVKTIQVFVKNKIPVRFGLIPVTFSDGAIAQLKVAHYLQETFGLASFMDYLEASASKNKLASPEKACFQAATQDRNPRPEKVSLSLDEVLNNGVFDATVSKTTAYLNRLGMKHEPSHAFVNGIPVTRNDKWAQEMSTKISRDTQLIQQKIADAEVDEDTWLPELFLSQAFDRRNPAIVPEDPKEIRAVDLVQIADSQGELFSQIPRIALDESNALESAHAIIVGNFDDESGYELLSAALESRKTHGEVEMLFLHNPKLEAPAASRSVAVRRLLNGGKEVDASQLLEAIASSASPAAEEVEDAAHFWEAQRAVVQELGLAPGERALIVNGRVVGPIAEDTSLISEDFDQLLVYEKQKRITPVAKAVKALEFDEKLSDPLDFVKLTSLTTLSTISDVPEGIYESTSDIRLYLFNRWNDARSAITVSNSEDPAITIVASIDPTSEVAQKWLPILKVLSELASVRVRLVLNPREEIKELPTKRFYRYVLDSEPSFEEDGSISRPTASFSGVPVEALLTLGMDVPSSWLVAPKDSIHDLDNIKLSSVKEGWNVDAIYALEHILIEGHSRDMTTKSPPRGVQLVLGTENNPHFSDTIIMANLGYFQFKAQPGLWNINLKPGRSERIFTLDSVGGLGYNPQPGDENNEVALLSFQGRTLFPRVSRKKGYETEDVLETNPRPGSAMDYMNKGFNFASGILSSVGVGTKGNTSGKQADINIFSVASGHLYERMLNIMMVSVMRNTNHSVKFWFIEQFLSPSFKSFLPHLAKEYNFSYEMVTYKWPHWLRAQKEKQREIWGYKILFLDVLFPLDLDKVIFVDADQIVRTDMYDLVSLDLEGAPYGFTPMCDSRHEMEGFRFWKQGYWKNFLRGQPYHISALYVVDLNRFRAIAAGDRLRGQYQMLSADPESLSNLDQDLPNHMQHHIPIKSLPQEWLWCETWCSDESQSQARTIDLCNNPMTKEPKLDRARRQVPEWTEYDEEIAALSKRVAAEKQQQAEEEERDNESYPNEDEEDEASSGWDKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVB1</accession>
    <name>A0A8G1QVB1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3beta-hydroxysteroid 3-dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.270</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_491772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.270" evidence="2"/>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511563.1">
        <property type="nucleotide sequence ID" value="XM_025663735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVB1"/>
    <dbReference type="GeneID" id="37167137"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF4">
        <property type="entry name" value="KETOREDUCTASE (KR) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="332" mass="36430" checksum="C57A2F95FE1C3D17" modified="2022-01-19" version="1">MEGTVLITGANGSLALGFIQALLSLHPQMTLIATVRNPSPDHDRNTAKLLNLIAGYPKANFHLEALDLGNLSSVRSFADQVADKISSKKLPSISAIICNAATFSFEAGQAFTTDGYEATFQVCHLSHYLLILKLLGSMNKTSGRIVLLGSVTHYPEKPNPLCSLRPGFPKNMDDLVRPPPDPANLVHDKGFQRYGTAKLANVTLAMDLNRRLKEDDHLSGITALAMDPGGLPSSRAQAGQKRSARWLFRVVEFLMPVLKYMTTMFRTLDDAGRDLVAVSVGDEFRGKLGYFVGTKEVAPAAISEDREAQEKLWENCWRWAGMRTEETVLLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVT5</accession>
    <name>A0A8G1QVT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH:ubiquinone oxidoreductase kd subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_480744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511818.1">
        <property type="nucleotide sequence ID" value="XM_025663023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVT5"/>
    <dbReference type="GeneID" id="37166425"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="154" mass="17348" checksum="480B090307750B2A" modified="2022-01-19" version="1">MLSQRILARRLPQVAARYTAPRASFSQVRSLKAAEVDDPLQNNNYQNPPRVKRAFRDPYGDWWDKQERRNFGEPVHEENEILGVFSPEQYTHVTARKGLLQVGAFVVTFLGLCGVVSMFYPDKPSVPKTYPDGLEKELGGPGAAPARKSDEASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QW11</accession>
    <name>A0A8G1QW11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UbiE/COQ5 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_523336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511576.1">
        <property type="nucleotide sequence ID" value="XM_025665337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QW11"/>
    <dbReference type="GeneID" id="37168739"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="36"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH53654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="270" mass="30168" checksum="A85F4D98D7741D01" modified="2022-01-19" version="1">MPETATYTHGHHASVLRSHGQRTALNSAQYLLPHLQPHMKILDIGCGPGTITVDLATYVPNGYVTGLEMVDDVLPGARQVAESRGINNIEFVTGDANNLAYADESFDVVLCHQVLQHVGDPVNVLKEMRRVCKSGGIVAARESDYSVFGWYPELPGLRRWLDLYDRVARKNGGEPNAGRYLHVWARQAGFEKPKVDCTVSAWCFTKPEEVQWWSGTWQERALKSAFAKGALDNGFATLEELESISNVWRQWGEDEDAWISIPSAQIICRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QW13</accession>
    <name>A0A8G1QW13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_462246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511953.1">
        <property type="nucleotide sequence ID" value="XM_025661837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QW13"/>
    <dbReference type="GeneID" id="37165239"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF2">
        <property type="entry name" value="KETOREDUCTASE (KR) DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="41937" checksum="0945BBD384DF2543" modified="2022-01-19" version="1">MGLVKPELNSSVMQCHSRTLTITVAGLVNISQPVVSHTPNTESPENMVSLEAVRAHNSNLEDLGTGLVAVFADVPVGGTSGIGLYAAREFVRHALSPTVYLVGRNEIRATEIIDDLKSLNLSSQIRFLKADVSLLKEVDSTCAVFRTQVNHVNVLFLSCGIFTLNRSREDTAEGLDKKLSLHYYARMRFIHNLMPQLTRASCILGSEGSRKLSRVISVLGGGHETELYLDDLDLQNHYGVENCDIHATTMTSLMVEEFASRYPSTTFFHTYPGIVDSGISRESGRFVGCIVKAVMFLGRPWMVSEKESGERSLFAATSREISTSAKSTTGDGKRNAMILNWDGSEVGNRRLLEEYRKKGVGDMVWKHTEEIFLKASKVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWJ9</accession>
    <name>A0A8G1QWJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_505945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510612.1">
        <property type="nucleotide sequence ID" value="XM_025664358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWJ9"/>
    <dbReference type="GeneID" id="37167760"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="176" mass="20197" checksum="7A717D22AF5195D8" modified="2022-01-19" version="1">MGRTYRTHHPKFAPGNTVNLRSYRRSLPFQRDDEGNITAYDKLLNDSRKNVEHYDSSGTLYANATEALQGDRFYVEQGDNGYRFKETETGKYLALKGHWIGLDDEGTDLWFEEWPKEEGRYIITPRGDNIYPGDGPGYHLWFEGAPDAVFRNGDDDLNVKGEGQHAIFWIDTLVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX10</accession>
    <name>A0A8G1QX10_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_377233</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513176.1">
        <property type="nucleotide sequence ID" value="XM_025656255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX10"/>
    <dbReference type="GeneID" id="37159657"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="42"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH55254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="470" mass="51682" checksum="9D90AAE516B5A030" modified="2022-01-19" version="1">MAEPCTVEDHVKMLESFLHPGEIIRPTSPDYQSRIETWAAQKQLNPHIVLRPTSVDSLSKAIAYIYSTNLDFAIYGHGFMSASASDVLVNMSAFDGFHLDRDSELATIGAGQTWSDVYQKLSEVAPEYGIVGARTPCVGVAGTIISGGFSWLSREYGCISDPANMLDAKVVKYDGSVVWASSEPDLLWALRGGGGGFGVVVEVVLRVFPYPQNIWAGPILIPREQLEVTADEMAKFVSRPLEPKISMFLYVVKKRLLKSIGADSDMLVLHAFDACGEAHGRANFQWALNIPGAIDQTKVTTFAGVADLQDKVHIAKGTMKQFWSPLLLRELSKDTIINAVRWSEDIGKLDESLGDCTYLIFELLCSRDPPGGVASCAWPRPQGVKHILLMGPGCPADAGRDHEDLVRDLAIKAGSTVLGENADLHYLSNGYEKFYDAKKIWGPHFAQLQDLRRRYDPLGRFKGAVTHSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXA7</accession>
    <name>A0A8G1QXA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_451648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513260.1">
        <property type="nucleotide sequence ID" value="XM_025660639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXA7"/>
    <dbReference type="GeneID" id="37164041"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="102" mass="10321" checksum="565EB2DC9033C368" modified="2022-01-19" version="1">MPAFLKNIKNKLKAIFKKKKTAEENPEGAAAPAENNPAADKPAEQAQTEGVSAAPPTLEVTESPAGEAKPETEAHAEAAAGASDAAAKPAETAGDAADKETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXS3</accession>
    <name>A0A8G1QXS3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_470353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513439.1">
        <property type="nucleotide sequence ID" value="XM_025662393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXS3"/>
    <dbReference type="GeneID" id="37165795"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="3">
        <location>
            <begin position="29"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH55517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="381" mass="42275" checksum="9C5E048A5F79526E" modified="2022-01-19" version="1">MIISFLLRCHDSIWAFLHATILNIPPSRLYIFPTLAGSVWFLTLASLLLTWLARGMPVYPGQSNPDVAFISDIASFELKPLFLIGASMTAVGFVFTVAAVHVMRYEPGFALVKCPVISEETSNNQGNNNTYTQSSDHNHRNAYNHITGGGHSEEEEEEDQETTRTLKVISLLSILAAGTASTALILLGVMDTFRYKFAHHIFLRICFGCLAIQSAGTAIVYSTEVLSFVSYLYHWGVWGNDWGRKRSNRVRIFASLSTILILIQLFLGVAFISLTIPEDANDYRTAGILEWIIAFLGTIYLWLFCGFFDRTSFEGYVPSILYNATPHGKFLGRPAVPGVGVAEAESSYNPADDTWDVDPERAPLLPQSQYQSEGGPGTRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXT6</accession>
    <name>A0A8G1QXT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_461225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513515.1">
        <property type="nucleotide sequence ID" value="XM_025661770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXT6"/>
    <dbReference type="GeneID" id="37165172"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF6">
        <property type="entry name" value="SPECIFIC TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="293"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="578"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH55593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="649" mass="71203" checksum="F4A9A675FB81CCEC" modified="2022-01-19" version="1">MELTWLADTPQSRRRTRALRACATCQRRKKRCRHLDTANGVSHNHVLQTGASSHVPLQRQQQSTAVTGDQPVDTTLAGSLSIPSSVPSSTSQTERFVGDLNPEAVIREKLDSANASHLRDRIGLWISSSDVHGHRKHVPNTDPEWTGHRPQNGPELQSVASALNQQYSSGMDACGRLPHSTRHHLFSIYFSKVNHILPLVDQASFAQASSDGVASVFLERAICLVAAKDRAAGPHLRFSNDGPLISSRSFCSKLYHGLVVALNVGLEPDRLCRIRILTLMSLHCEGYEGAEAASMHLCQAIHQAQTVGLHLDRPGRAPGDSLFNLFWCLWGLDRMHACIGGRPVILSDCDIGIEKPKIQDISPRSAFDIWFAISDLLSTVISLYRPSSDHTVGWEGEFPAFEGITGDKLQGDLDFTTLGLLELYYHAVAILSCRYKVTHRSDESRPSYVRQGLAAIRIHSIAAIECSQELPPLPIVPYALALSMGVSYQQFRSSKLITHLDRARTSLEACCTLLEELGGLWYSAEATARLGRKALHQIDEAELGHHQHGRAASPATPTTQNPRAFLSPPPDSSFDPAQGTQSNVRSGAPSTALGQELPPRPFYSQDISAPDPEHDSFTDIDTLFGDFLDLSLPTNFWDPLFMAEPPPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXX8</accession>
    <name>A0A8G1QXX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7 9">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="12" type="ORF">BO85DRAFT_490135</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7 9"/>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXX8"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="11">
        <location>
            <begin position="123"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="322"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH55592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="373" mass="41284" checksum="7BA9A410AF662FEC" modified="2022-01-19" version="1">MAGRAGMKRDANHLTTPEADSKKPKANGSITSFFGAPKSKPSDPKPTSSSSSFNKQKWVDSLTPEQKELLQLEIDTLDESWLAQLKEEVVKPEFLALKRFLQKEKQSGAKIFPPEEDIYSWSRHTPLHKVKVVIVGQDPYHNYNQAHGLAFSVRPPTPAPPSLVNIFNEIQNDYPSFQRPANKGGLLIPWAERGVLMLNTCLTVRAHQAASHSNKGWELFTQKAIDLVARVRTRGVVFLAWGTPAGKRVTGINRAKHYVLQSVHPSPLSASRGFFGNQHFKKCNEWLAERYGADEVIDWSLTSKSKISSPFTTIQSPALTGAPKKSIAKESDASLVKEEVSKTTEPAKSTEAVDEFEDDLDALEALAAAEVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY34</accession>
    <name>A0A8G1QY34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_52972</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514453.1">
        <property type="nucleotide sequence ID" value="XM_025665452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QY34"/>
    <dbReference type="GeneID" id="37168854"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF7">
        <property type="entry name" value="PA-PHOSPHATASE RELATED-FAMILY PROTEIN DDB_G0268928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="158"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="236"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="354"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="449" mass="50544" checksum="36D407119B4B8A83" modified="2022-01-19" version="1">MGVGAFLEPLTVIVLLFGGTWINRTTGSFPARRTRRRSSIPSRGSSPDATESGLSTPTAKDGLLSRRLSSSSSALLQDGQSRWRKRQLGIFSSTLEVTSPNTIVFQDRLLSRLLRKFPFLVECWYWALVYWTYQLGRAFTAVTLQEGTVDVARKHALQLIQVEEALGLFLEVPIQRFFLRHTRLMMWTNWIYSFIHIPGTIAFLVWLYYYTTTRNRYDESQPGKPRGFMSGSPAGPRLYQARRRTLAVCNLLAFVVFTLWPCMPPRLLSDKDAQGPDAARGRSYGFVDTVHGVNGAGSVWTENRFCNQYAAMPSLHFGYSLMIGLTIMTIPLPPHHRRRSRIAIGPVGLQVPSWRRLVCLAMGFAYPFVILAAIVATANHFILDAVAGATVCALGWKFNGILLNLLPLEDYFLWALRIHKPVPTALEEFEGADGWTDDEGLPEHTSLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYS2</accession>
    <name>A0A8G1QYS2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium-dependent phosphotriesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_452953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511707.1">
        <property type="nucleotide sequence ID" value="XM_025660953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYS2"/>
    <dbReference type="GeneID" id="37164355"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="334" mass="36927" checksum="B9F3D6493D4B610C" modified="2022-01-19" version="1">MTNSEITGFQSHHKDFDAITGPIPTLELLAEHRDYPFAHEAGIYIPETNNLWITSNRCVDPNGSKSEQKVYVTRVDLNTNPITYEEIPTEIPMGNGGINYGRDHILICGQGSMTQPSGLYQMSITAPYTTELLKGDFFGRPFNSVNDVVVHTDGSIWFTDPIYGYRHEYRPEPCLPCQVYRWCPREGTTRAMADGFGMPNGICFSPDEKTVYITDTDRLHGDGTVFDHRVSSIYAFDVSTIHGQPFLTNRRLFAMADHGIPDGIKCDLNGNVYSGCGDGIHVWSPGGVLLGRILIDGGVANFCFGRNGEIFALNEHRLWGVQLGVGVKGALLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYT5</accession>
    <name>A0A8G1QYT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_479814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513284.1">
        <property type="nucleotide sequence ID" value="XM_025662974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYT5"/>
    <dbReference type="GeneID" id="37166376"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF7">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="33787" checksum="7F5955ED44E117FB" modified="2022-01-19" version="1">MKDAAYCPVDDGSDCRGSRSLDKDEARRVLLSKPFEDHVVHSSPPMSRKYLFFGLFCVVLLMLNTIMLVFNLWTTTPHSRQEGFIQKPTDYWLPGFENGIVYEKRQFYSAHSEYAGVGPEVDAKWHDLTRGAMGISRQQLTALNNHPDVAVQIENAGPDQEYLATFDVLHQLHCVDLLRKGIHMDYYKDKDEHFVNQTDERIFFHLDHCVDILRQTLMCNDDLSLVTYNWVQGLEIPYPNFNTYHTCKNWDTFFALNQKLDVSARWEGGKVVEEYPIPRKPEHVDGMWPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYX6</accession>
    <name>A0A8G1QYX6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_426095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513344.1">
        <property type="nucleotide sequence ID" value="XM_025658104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYX6"/>
    <dbReference type="GeneID" id="37161506"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20446">
        <property type="entry name" value="Tudor_SpSPF30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041297">
        <property type="entry name" value="Crb2_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF2">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18115">
        <property type="entry name" value="Tudor_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="100"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH55422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="291" mass="31508" checksum="98A3EF7B1FABFAF5" modified="2022-01-19" version="1">MSDVAALEAEVKEFKLQLETVQSSLQVDPDNTELQSLKTELEELINLTETSIAELKPPAPAVSQPPASAAKDNRAKDSYASQPTYRKPTVEQTDEPSTQTSFSVNEHVLARWVSGDNSFYPARITSITGSASNPVYLVSFKSYGTVENLTSKDIRPISGNDSRKRKADASSGNSSSQSPAPPPPHSSVISAAADINPALANQARKEPSKVSDGPARPAKVPRKVKATRELEAGKMKWKDFASKGKLGRKESMFRTGDGVNARVGFTGSGQQMRKDPGRSRHVYQQGEEEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ65</accession>
    <name>A0A8G1QZ65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_499150</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513226.1">
        <property type="nucleotide sequence ID" value="XM_025664059.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37167461"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="5"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="942"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2325"/>
            <end position="2402"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="3449"/>
            <end position="3526"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="942"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1096"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2449"/>
            <end position="2468"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="973"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH55304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="3911" mass="428374" checksum="E8DAB6C053A4EF59" modified="2022-01-19" version="1">MAPEREPIAIIGSASRFPGNATNPQKLWELLIHPRDVGKVIPGDRFSVDGFWNVDGSHHGTSNVTKSYFIEDDTRRFDANFFNINPREAAAIDPQHRVLLEVTYEALESAGLSIDILRGTPTGVYVGLMCADYLDVQLRDPEALAQYHATGTARSILSNRVSYFYDWKGPSVTVDTACSSSLVAVHQAVQALRQGECSTAMAAGVNLIFGPEMYIAESNLRMLSPTGKSRMWDSSADGYARGEGVGVVILRRLGDALRDGDPIESVIRETAVNSDGRTNGLTMPSSASQADLIRQTYRRAGLDPTKASDRCQYFEAHGTGTPVGDPLEAEAIHSAFFPESNDGCQVQESQLYVGSIKTVVGHTEGAAGIAGLLKASLALQHEIIPPNLHFKRLNPNIVPFYDGLHVPTKPIPWPPAQVRRASVNSFGFGGTNAHCILEHYAPSVHGGAKEGTEKPMNEPAVESPLISLPFSASSQSSLARLIQQYAGFIATHPSVDMQAVSLALQKRSNLPFKHYVTGLSHNSILQQLQDPQWKPGPSGRGAEAHNSAILGVFTGQGAQWPTMGRELLLRPGPFTATIDRLDDILQQLPDPPTWSLRQEILADPDTSRCQQSTYAQPLTTAVQVALVDLLYSVGIRFSVVVGHSSGEISAAYAAGCITAEAAITIAYYRGLYSPRADLGEGGPKRSMMAVGMGFNEATRFCTQPEYAGKIFPAASNAPSSTTLAGDLFTLEFARDELTRQQKFARILRVDKAYHSPFMEPCAEPYMQALQARNFAYRTSGPSCTWISSIHGFEMDCSSDCVNDSYWLKNLLQPVLFSDALSQAIRDHGPFNCAIEVGPHPALAGPAGQNFKALQQNVPAYLGALTRGENDVLRLSKCLGEVWKLCGPSSVDLRVFQSLINGEDGILPAMLPKVLPSYPWDHERPYWRESRASKEYRTRAPSHELLGVCVEQSEQCWRWRNILHPREIPWLQGHEFQGEMLFPAAGYCIMAMEAALRFSYPRPVRLLELHDLDIRRGISIDGSADGIELHCHLGPNPTRESKDSSAFGIVNLNFTCIAGHVDGSDVLTIRFTTRVRLEMGSPGLTVLPRKQQQSPGNFPVDIERFYGSMSRLGLNYTGPFHSLLASERRLFHASATVAHVPSSSSFMHPGVLDTCFQTLFVAFASPDDESLRTPHLPREIQSIRFNPAVIAHTDHPRGSPFQVESYVTKATPPTRKIPSDMVGDIDVYTTAGDCVMQIESLRCVALAVTTEKDDRAMFHRTHWDIDIDAGMVASFDKPNTEYSTILEQFEAVARQAIDGAPPAIGDIVSPELQLIQKAISLHFAPPSEVPGAHEAFKAAQNRYWKTSAGAQRMQEYVVRTVKQVTHKYPRMRILLFLGGNDDVSVARRILDAINGNCTSLILTDSSSETLKSAKERLKPYGDAVQVETLDLGTSPPEILYDMVIVQIGVLGEGAASIPLGYCRRVLKTGGFLLFGSITGRGNFAGCLQGRLVDDHRINSEPERIWEALLQQSGFSGLDSVAYDTGSPRLHCHSLILSRAMDASLQSLQHPLAYPDQTNEAVDKDHVLIIGGHTGIGSRGLQALRSYLSKWKRGFTYVASLEDLGSYKSQNIPSHVLCLTDVDAPLFQNLRAEQFAALQRLFQDAHNVYWVTRGFKQGDPYSAMTVGLGRVVQTELQGLNLGFLDIDVVDENVITQIATRFAQFVNHGQHSHAISVETSLWCQEREVSLENGLPYIPRVKHAQDMNARFNSAFRAIEQPLGLDASLAKQSDTASELEVVSSVIARSAHALKLTNEVDAYLCLVNIKCTEGDRLGLIISSSAEEKVVVCKRDDILDIGPRQDHRISAPEILSILVALHISERVQASLCYSTTLVFTNDPWLLSVLAMSRESDQRALLLATSDEGAMEWDKSIIYVHPYTPTRKLMSMVPQSVSKFINLDTEFQPLHDRLLAAIPRTCATHSANDYLSERASIGHVLSPSQSSRDVLDMLWTQWLISSAALQSIMQPDTVVPHSHSACAVKSYTPQENPLVTVHRLDPSTILRRDATYLLVGMAGELGQSLCRWLVANGAKYLVIASRSVKPVPWHEELQQSSGCHLMTLPLDVCDMQALRIAHQTILQFMPPIAGVVNGAMVLADAIFVNMAYEDFTRVLGPKVRGSRNLDELFSGNELDFFIMLSSTASLIGNAGQSNYSAANMYMKALAEQRRKRGLAGSCFDIGMILGVGVVSRERVYEEPLRKAGLMPIAEPDFHCMFTEAMWLGRPDMTTNSSPCFSTGLHVPPGPVRPAWYHDPRFSHFQVPEEDASRSAGAVKDAAVTLGQQLRYTSELTRAEDLIQEAFVVRLQGLLQLTGPIEDVARALSELGIDSLLAIEIKTWFFQELGFQVSVMKILNGISVRGVCREAAEHVFRAKAAESDEGASTVESVKVLKTLEVPTPRMQEDEATETISTVARTQETPFSDTSSQTSHAVETPTSSQVLPVAGLSIPTMAAMSTEQEKIWFMLQSVDDPAMYNCTIQYELHGPLDRVRFQAAVTEVAQRHESLRTAYVTDPHDQIPRRVFLGQPQITWREVGMKSDDKDVIATEFEALQTRAFDLAKGQTMAITILSHGSARHAIIFGYHHLIMDGVSWQMVLREFAAAYQDRQSLSPVVAQYSAFCNQKCSTSEATTPAWNEGPSSTYTDGQLPDDLPLFPFARTGFRTRTRTSYETIRVSSYLGTEDASRVRSISSRTGATSFHIHLAAIQLLLQQTLEVDRFCLGIAHANRNDPRFERVVGLMVEVVPLMFEPQQAQGFKDLVKDTRSRVLGALSQAHGSGKSSRPCDIVVNYIAGVTHDIMFDEAVLKYSTSEDARQPHDLVITVRDNPDGTTVITFGALEYLYHAHDVQLLLDLYVRLLGSVSLNSDLKLEQYRCLEPLCLKAPSQPPTSQAELSAIQKEPDRLTQWIARIAATYPDTVALKDGNGRELTYAVMESRVRSIMDILLAVGVQPRAFVVVACGPSVDTVCALLAIWRLGAVYVPADLEHGVERLSLILKDCSPAALVCRSRAGVDHFMADQGPQVVELKMHLPPPSPATLDYDRSTGQDPAILIYTSGTTGVPKGVLLSHDNLLCHFAAVQQVFPVDQPVVLQQSSHNFDASFFQICVSLLHGGTLVMTSNRQDPIELAELMVREKVSLTLGVTSEYALWLGEAASVLRNCTSWQYALCGGEKMSSGTLQGFSGLNIARLKLINAYGPCEASVACTMGEIDYKRNNLHDSHDPIPVGQPLPTYAIHILDDQLQPVAAGWPGEICISGGAVSSSGYWNREDETSARFRVFNGIRIYRTGDYGRILPNGNLEYRGRLKGNSQIKLRGMRLELEEISSVLVQTSQGVLREAAVIVKGHPEPYLVAFVVFSTSGSPANVGSFLDTLRSGLPLPTYAKPTAITPIDRIPLTTSGKVDRTALARLEIHQHQSVSSTSGALNIIEMKLKELWQELLPATGLSITPQSNFFDLGGNSLQILRLQGRIRAITKVSVPVVHLFRCSTLSEMAQLIGAATSAHRASSPPPPAPAASILIDWEAETAIPSSFDNLITISDPHTQLPFNPPREVILTGATGFYGTALLDHLLSIPSITRIHCLAIRPNADGSPRQLEHLISPKVHLYSGDLSHPTLGLTEAEIAHLASTVDCIIHNGADVSFLKPYSALRAPNVDSTKFLFNLAISRGIPFHYISTASVTSLSGKDEFLESSVASYPPPKDGSPSGHTVGYTASKWASEVFLEKASTIYTDVPVCIYRPTAITGEGDMAIASTSGGVIESVLDLSRRMRVIPETWLWRGYIDLIGVKKAAEMVVGRVVGGDDASGVGVQYSHVCGEKRFKASGLRMFLEKEVGSEFQQVEWKEWLSMAAEYGIDDGVAAYLEGLQAGSGSSADLFFLPLLGGGLSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ67</accession>
    <name>A0A8G1QZ67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-CoA hydrolase</fullName>
            <ecNumber evidence="4">3.1.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetyl-CoA deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_521121</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O = acetate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="3.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.1" evidence="4"/>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514346.1">
        <property type="nucleotide sequence ID" value="XM_025665186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ67"/>
    <dbReference type="GeneID" id="37168588"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.70:FF:000002">
        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000003">
        <property type="entry name" value="Acetyl-coA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.20:FF:000001">
        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.70">
        <property type="entry name" value="4-hydroxybutyrate coenzyme like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046433">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609:SF1">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase C-terminal" evidence="10">
        <location>
            <begin position="333"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH56424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="525" mass="58206" checksum="A8B1D5AC7CDCA4C9" modified="2022-01-19" version="1">MSASALLRSRVRRPSYLNRLAKAEDLIDLFPNGSYIGWSGFTGVGYPKKVPTALADHVEKNKLEGKLKYTLFVGASSGAETENRWAQLNMIDRRSPHQVGKEIAKGINNGQINFFDKHLSMFPSDLVYGWYTMNKPKNRLDVAVIEASAITEDGGIIPGASVGASPELIQMADKIIIEVNTASPSFEGLHDIVMSDKPPMRKPYLIMQPEDRIGTPHIPVDPEKVVAIVESDYPDQTQPNAPEDEGSQAIATNLIEFLKHEVKHGRLPENLLPIQSGIGNIANAVIGGLSKGGADFTNLKVWTEVLQDSFLDLFDSGNLDFATATSIRFSPEGFKRFYDNWERYAGKLLLRPQQVSNSPEIIRRLGCIGMNTPVEVDIYAHANSTCVMGSRMLNGLGGSADFLRSSKYSIMHTPSTRPSKVDPTGVSCIVPMCTHVDQTEHDLDVVVTEQGLADVRGLAPRERARVIIDKCSHPDYKPILQDYMDRAEFECLKKGMGHEPHLLFQAFKMHQNLQEKGTMKITSWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZU2</accession>
    <name>A0A8G1QZU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromatin remodeling complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_450675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513948.1">
        <property type="nucleotide sequence ID" value="XM_025660433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZU2"/>
    <dbReference type="GeneID" id="37163835"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10211">
        <property type="entry name" value="ASKHA_NBD_Arp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000048">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000139">
        <property type="entry name" value="Chromatin remodeling complex subunit (Arp5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000176">
        <property type="entry name" value="Chromatin remodeling complex subunit (Arp5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000025">
        <property type="entry name" value="Chromatin remodeling complex subunit (Arp5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH56026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="752" mass="86762" checksum="7D0FABB20036F609" modified="2022-01-19" version="1">MAITSIQPVLPTRFTINSTEKGAKKPPPEPYHVKDHPFKGYHPPQPEGYEKSKSTSAIVIDNGSNLVKAGWSFDKSPRFVLPPVMSRYRDRKLNKACQFIGYDSYVDATTRGQLRYAFDPGTSVVGNWDVMEGVLDYLFIKLGVDGANGGVDRPIVMTEPIANLAYPRRMMNEILFECYSAPSVAYGIDSLFSYRYNRGKDGLIISSSHTSTHVIPVLNNKALLSNCSRLNWGGLHASEYLLKLMRLKYPTFPARMTESQMEDIVHKHCYVSKDYDQELSHYLDWTGLEERDCIVQYPYTEHVVPEKTEEELARIAERKKESGRRLQEQAAKMRLEKLMKKEQELEYYKDLQNGLASETKKEARRILEAEDLKDEAHLDRLIRDLERSIKRSRNRDLGIEETEEPQEEMSFPLLDVPDEELDEAGLKEKRHQRLMKSNVEARQRAKAEKEREKARREEEERLDREKRENDFENWLAERRANRQNIMQKIKERDRMKADLGNRKSLASQMRMKTLANLAADGPKKRRRGGDDDTFGANDEDWGVYRTVATGEQSDEEEEEDLGGMLDTVEKELLEYDPEFTENHTLAAQSDWTKSLVHVFLRGPWPFDPESQREAHQLHLNVERIRVPEVVFKPSIAGVDQAGLLEIAADIVNQRFPNPEEQSKLLRDVFLTGGNTMFKNFDERLRNDFRAYLPVDAQLNVRRANDPVLDAWKGAAQWASGSELAKSSITRQEYLEKGSEYLKEHDMGNATTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZX9</accession>
    <name>A0A8G1QZX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_500264</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="6"/>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512322.1">
        <property type="nucleotide sequence ID" value="XM_025664104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZX9"/>
    <dbReference type="GeneID" id="37167506"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF1">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE C186.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 17" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="18">
        <location>
            <begin position="24"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH54400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="954" mass="103922" checksum="2EC3FADE3EED64B6" modified="2022-01-19" version="1">MSLATPQEWEIPVSQRAYLSKSHGGRLELATIDVPKYRVDEVLVKILFSGVCHTDFHAWKGHWPVKPKNNLVGGHEGVGIVVALGKDVRDISIGDKVGIQWVNRTCEVCGFCSRGSQPLCPHIQLSGYTVDGTFQQYCVCKAGNAVRIPSGMPLDQAAPILCAGLTVYKALKECKLEQGELVAIAGAGGGLGTLACQFAKACGYRVLAISAGESKRRMCVEKLGADYFVDYKSSSDLVEEIKEGTEGGPNAVIVVSSTTKPFDDAIHYVKPMGTIVAVGLPPGCMNADIFTIVLRNITIKGSYVGNRHETEAALEIACRSGIIPPYNVFDVHELPKVYERMETGEMEGRAVLRIADDKAQSTPVRLTTQLKPRFCPEQFTVGTRLAYRLEELGVTDYFAVPGDFNLGLLDELLKNGSIRTIGCCTELSAGYAADGYARSSPGKVAVVFVTFMVGGLSLINAIAGAYSEGLRVVVISGCPPQKAFEDKRLVHHTLGTNDKDQALRMFDEVTALSVRLSSSQNPAEALDSAIIKCLNASRPVYVEIPTDVAQASCTPPGPLPINGSELFEMDYALNAVDAVTNCWNGAKQPILLVGAHVRQTVLPHVLVSLIDKLGCPVLVQPDGKSLVPEDHPQFLGTFWSSASDHKSEKVFMDSDLWVMVGCRWTDYHTLGCLDIRKESHRILDLQDGSVTIPSDESYTDIPLNELIKLIARSKIQHKGTVQPNGIIPTVKVKRATIDTSKLSLSTILGGIQEVIGPENSVIADTGDSWFNGQMIKLPWGADYQMQMVYGSIGWSLPATLGYQLGRPNQRVILMIGDGSLRMTFQELSTMISLRLNPIIFVFNNLGYAIETAIHDGPYNYYSNWNYTSLANSLCSTFHAIYDNPYVDHKLTETCSDPPMFSAQIKTTTDLLIALRRAVHEPKKLAFLECCIDPSDISSSLQRFGLAVGTRGKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R072</accession>
    <name>A0A8G1R072_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_427618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512457.1">
        <property type="nucleotide sequence ID" value="XM_025658163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R072"/>
    <dbReference type="GeneID" id="37161565"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF6">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="276" mass="31841" checksum="C8DCABE520693B4E" modified="2022-01-19" version="1">MMEGFGEVFLARPEYQVISELVHNPGVSPAEAVQNLLRVREVLHQEGGEPPTEIDGTHTWIAMVTVVKIVNLTPAAQQHKLIEFIAHLQRTKIVDPDTGQEPTSEGMKLWTELPYLGVYLRDMYSFTYDPKYAQKVDDDPRKEYPPRELQEWENRNAFMAQLTAKADHLGHAIDASLYALWACRETFEESDLLVEEAVRISCIWYIYAGQRIWENCQVQRTFGDADDPPPRPRFTMEKWHLWKDGLKAAQVHFSRVSTQEMIQKALAEIEKAERGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0X8</accession>
    <name>A0A8G1R0X8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_86846</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025665747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0X8"/>
    <dbReference type="GeneID" id="37169149"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF12">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="95"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH54910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="572" mass="62284" checksum="41F516B63F3EAE45" modified="2022-01-19" version="1">MSSAKIPSSDPPAGPGDSKEGPTSTYAQSYAVSGSSEDTIDQVDDLAHIPTRASRASIPSLAQRVTSIGTTGTSDPNYEVDWDDEFDTNNPKNWSFPYKAMGIAILSYNTLIIVLYSTSYTSGESQIAAEFGASTTIVTLGLTLYLIGLAVGSMFMAPLSELYGRKPVCIACLFIFTVLIIPCALAKNLATLLVVRFIAALFGSVMISTAPGMVADIVEDDQRALAMSVWSLGPVNGPVLGPIIGGFVTQYLGWRWMDWIALILSGVALVFACIMKETYGPIILQKKAARMRKETGDSRWWCRYEQKASLSELLKINLGRPFVMAVTEPICIFWNIYIAIVYGILYLCFTAYPIVFRDIRGWSLGLSGLAFLGIGTGCVITISSEPLIRRLINSHKPDPETGKPPPEAMVAFVCICALLIPAGELWFAWTCSPASIPWIVPILAGVLFGTGNTGVFIYATNYLAGSYGVYAASALAGNSVIRSILGGVLPLVGTYMYAGLGPNWSGTLLGLLEVAIVPIPFIFYKYGYKIREKSVLIRRMQEDKRRLAGKRQHHTQQVENLEKIEEKETMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R137</accession>
    <name>A0A8G1R137_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sit4-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_439137</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515225.1">
        <property type="nucleotide sequence ID" value="XM_025658698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R137"/>
    <dbReference type="GeneID" id="37162100"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="483"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="876"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1101"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="629"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="882"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="941"/>
            <end position="955"/>
        </location>
    </feature>
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        <location>
            <begin position="960"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1012"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1038"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1053"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1112"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1137"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH57303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1146" mass="124181" checksum="26F0328F5B809699" modified="2022-01-19" version="1">MFWRFGGYASISAIDTLLDKPDVTLEELLDESELIQELKQNNTKLIEFLREDNVLKRLMDYVTAPSLVNEDDEDDDDHETNAQTNRDDDATEEAKGGDPLKDILDPEDLERAEKDRMKRAYVACEILSSEIWSIVESILLNPDNLRDFWGFLRRSSPLDSAQASYFTKVNETLFDKKTSEMLELFKSMEGIVPAILQHVDNPMVMDLLLKIISLEKVEGGHGIVDWLKTQNLIPTLLSFLSPDHPASVQTSAGDFLKAIITISANATQNDQSCIGPNSLTRQLVSVPCVESLIKAMLQGGNPLTVGVGIVIEVIRKNNSDYDPENINGPDSLPTTYDPIYLGNLLRLFAKHIPDFMALIQSSKHTVNDGGKVRSVERGKLNSAWGAKIEPLGFDRFKTCELMAELLHCSNMGLLNEPGSDDYVRQRDAERERLMREGVFNPHREETSAFDGNDDSTVDFVNGSVIGYGSPEGSRVLEVANTGEESFEDVSASGVLVDKEKDAEVKDTSSPESKPESAAPSQHAPTETAENASNGASEDGSHDENPASQVRAHTPTSDPVSATASGIAEVSLGGGQTTKEGQPAAEAASNGMEGQTTASSQAQQESAPLVDQTNNQQSSLTPDAAGQVGDASSSVPTASESAPNDGDVPRQLHPDVQIDSNGQPVVGDYLKIMFVENKVVPTILDFFFRFPWNNFLHNVVYDVVQQVFNGPMDRGYNRLLAIDVFEIGRITQSIVEGQKRSDEAQRTKQIRLGYMGHLTLIAEEVVKFSERHPPELLSPTVMENVLNPEWIDYVEQTLSETRERDNAILGGVRPDMSIGHRQGMLNSGQSANTSSALADAGLNGSVGGSGFQGFDMMNQGSVSGGAFGLNSGNSLLSGFASSSDDDEDEEMEDQDDRNMAEPSAEGGSDNASTNSTSQPIPILPPPPAPLSQGPSRARRQLAARLAAHKQQAAENSEGGEESSHNQQSEHDMQWPTNPFVIAGLDEDADGSNSPASAAFPSTDFPPANKDEPFSSPTFPDSGFSPPDSFSTNSSDEDGEGRPEGMRRKERVPLEVDEEEDDMGEMVGPSLGSGMMDSDEEDEAIMNESLGYPDIASGRYRNFGRSRMGASPFGDDEDDSSDGEDDDGLVEILVPGRKASTSSTTSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R209</accession>
    <name>A0A8G1R209_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_513620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515891.1">
        <property type="nucleotide sequence ID" value="XM_025664715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R209"/>
    <dbReference type="GeneID" id="37168117"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="13"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="501"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="696"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH57969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1166" mass="128466" checksum="CB7F39B79D1B37D1" modified="2022-01-19" version="1" fragment="single">MTILVGKPLSWAITTTAGSGFLLFGYDQGVMSGLLTGTAFTRTFPEIDTTATGHGSSSLQGTVTAIYEIGCFFGAIIALLIGERIGRRWCIIAGCIILSIGAALQCSAYSIPHLIVGRIVAGVGNGLNTSTIPVWHSELSKAASRGKGLAIELCINIFGVMTAYWVDYGMSYVVNDAQFRFPIALQILFAVITLAGIIVLPESPRWLIAHGRHDEARHVIWAVQPNARFIDEDDAAVTADVTEITTAIAEEREATQEGSFKLVFTNGHQKFFYRTLLGMGGQMMQQLSGVNLITYYNTVIFEDSVGMSHNLALLMAGFNGVAYFASTFVPIWAIDRLGRRKLMLFAAAGQCACMAILAGTVYDGSHASGIVATVMLFLFNFFFGVGLLAIPWLLPAEYAPLSIRSQAAALATATNWIFTFLVVEITPVSIKSIGYRTYIYFAGDEAKPTCTGCKRRGDKCQWRMLGSFREANIKVLEPGHPSMNQTARGTRKQSKFKILNVVPSPSRAAGKERQLSPPVDEGRGSSPSARSLPGNGEGEGEVVRPDGLENVSGAAPDAHPTVLSPGSNQAVSPLSHHSFHAHEVNIGNGHSPHQANELPHPYPDEAPHQPYIHSSPEFVVDELTALRNLSNNAGHFPGPEVYQSITSPLFDHSVFSDPANLTNDVFVPGSAYEALHTTLRNRQLWTARTEIPSRASTPASVLEYDGPTPDTSHIQRSRRAQSRPGRDFELTPERENILWQNYLNEICLWLDMFDNHRHFASTFPQMAKSAPHLRYSILALSARQMERQQNKKSQSESLLLYQEAIHQLLPELEQKTTPVIASCVILCVLEMLSCNPKEWRRHLDGCAYLIQAAEINGFSGKEEQALFWCFARMDVCGGLISEEETIIPIHHWIPRDMTPTEASQLFLASNMTTFDTYANYTVFLCAQTLGVLFGGSSQLSASCVSCNYLSSPREGESYVQRWQRLFDDVEQCGREDNGEGRWGKTVSDGAVWERGCYFRKPALPCLCIAFAATKTEDGILATATEIGVVARAANLLYFRIEYTPPLWLAGKVMSHHSEHTAIIETLTRIERETGWATAWRVEDLKEFWGDEDEDVDVDMDGGMDLDLRSERVRGSIGSIPSSRSSMQARVGREEFWGLMDIIGLIGMIEIGIHQAGNERDEDLTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R284</accession>
    <name>A0A8G1R284_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_373824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514831.1">
        <property type="nucleotide sequence ID" value="XM_025656099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R284"/>
    <dbReference type="GeneID" id="37159501"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="2">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="788" mass="86307" checksum="D6584EB7F5D67798" modified="2022-01-19" version="1">MSQQDLDRPSARAPHNESPEPYSVHTRSRSTAHAHSPKRLSVFSGRSRSNTTNSTTSSRRSPASSMTSVDAASLPSHDDRATSAAGVRHERPESVTKSLLSRGSRILRRQGSKFHIVSTLDEEDEMEREKPRFEVSEIFSRNKSRHSDAHDQLKNLISDPFDFHHLTHTSPSQFQSLEKARETDLVTEFSAIRASQRPVTNLKGIRAEDLHFRDFSTEDLTQCGTAIGCDDVVPPPPTSPPASPGGSSSVSPKQRDLRGRRESRVIENFSRPVPRFPRVGSTSPPPRASSPRLASSPELPEPAPRAIDEILGLSTQPTYPEHVYSHTEDVEHGAAWPQIPMEDMFQPPSGHSFPTSVNNEVMNARTSSMSLPTLSSDLEDVPEEEEPAPWHEGAGLETDEVSPRAPVMSRSPPLSEAQSLSNTSLAGPRSDLSIFVAEDLSRKFAEALGSPTLPQDRIAPLQESMAREPVRRRSSVNLKAIQETIYESWDADIDYCYEHAAESNCNFDWTRSSLDEARQDDAEHGVTGADGNTAMFEPMRLSASALPAADLDHVPSAQVVVTSTLDDNTGIAVTQRDSDYFQPVRFAPTLGKHISPDSLYDEYLTADTESDRHFAFYSQPGVIQPMDQSVSPRSSFSPISKCNSQESLILSRAASVVRKHRSSVSTASVPDLVHSLASSREFHPSEQRLSGELSGMGRPESSHHRQTKSLAREVEAQLLFRADGDASPEPSGYASTVGPSIHDRAKSTTEVEAGPLIARAIKNDAASRSAPRRKGRASYSLFPTPAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2F3</accession>
    <name>A0A8G1R2F3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_448793</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516718.1">
        <property type="nucleotide sequence ID" value="XM_025660022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2F3"/>
    <dbReference type="GeneID" id="37163424"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000043">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1370.20:FF:000001">
        <property type="entry name" value="Catalase HPII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF3">
        <property type="entry name" value="CATALASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034694138" description="Catalase" evidence="15">
        <location>
            <begin position="16"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Catalase core" evidence="16">
        <location>
            <begin position="53"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH58796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="727" mass="80250" checksum="55C95B087A1E1630" modified="2022-01-19" version="1">MRPIGLVGLIGLANAACPYVSRDLSARDSSDASESTEEFLSQYYLNDNDTYLTSDVGGPIEDQNSLSAGERGPTLLEDFIFRQKIQRFDHERVPERAVHARGAGAHGVFVSYGDFSNLTAASFLSEKGKETPMFVRFSTVAGSRGSTDLARDVHGFAARFYTDEGNFDLVGNNIPVFFIQDAIQFPDLIHAVKPRGDSEIPQAATAHDSAWDFFSQQPSALHTLFWAMAGHGIPRSFRHVDGFGVHTYRLVTDSGASKLVKFHWKSLQGKASMVWEEAQQVSGKNSDFMRQDLWTSIEYGRFPEWELGVQIMDEEDQLRFGFDLFDPTKIVPEEYVPITKLGKMTLNRNPLNYFAETEQVMFQPGHIVRGVDFTEDPLLQGRLFSYLDTQLNRHGGPNFEQLPINQPRIPIHNNNRDGAGQMYIPLNPNAYSPNTLNSASPKQANQTTGNGFFTSPGRTTSGHLLRSTSPTFQDVWSQPRLFYNSLVPTEQQFLIDAIRFETSNVKSTTVRQNVIIQLNRISNDLARRVARAIDIPAPSPDPTYYHDNKTTDVGTFGTPLKKLSNLKVGFLASVQTPSSITAAQDLVTELKDDEVDVVVVAERLTDGVDQTYSASDAIQFDAVVVAPGAEGLFPEGSVTAPQRNSTASAVSTLYPAGRPLQVLVDAFRFGKTVGAVGSGEGALRNAGIDDEREGVVVGQTVGAEFVDSVREGLRTFRFLDRFALDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2K6</accession>
    <name>A0A8G1R2K6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_65509</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513657.1">
        <property type="nucleotide sequence ID" value="XM_025665565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2K6"/>
    <dbReference type="GeneID" id="37168967"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000095">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034053163" description="chitinase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="12">
        <location>
            <begin position="57"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH55735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="445" mass="49190" checksum="94C58055D4BE61C7" modified="2022-01-19" version="1">MKLFSLLLVALVSLVSSAHHHRHRHGINDLDPTKFPGPSHLEPGTHHLIPRNTSTEYKSIAYFVSWAIYARNHTPQEIPVDKLTHIMYAFANVTSSGDVILADRWSDIDKHFPGDSWNDVGNNVYGCVKQLNLLKQKNRNLKVLLSIGGWTYSPHFVIPASTDQGRKTFASSAVKLLADLGFDGLDIDWEYPANEAQASDMVLLLREVREELDKYSREHGNGTPFLLSIATSAGPSKYNTLHISAMNLYLDFWNVMAYDYAGSWDTTAGHQANLYLSRDDPKSTPFHTEQAISAYVAAGVPAHKLILGMPLYGRAFLNTEGPGKPFNGIGKGSFEDGVWDYKALPPAGANVSELRTIGASYSFDAAKRTMISYDTPAIARQKAEYIRNKGLGGAMWWETSADKVGAESLITTVVDSLGGTGALERSENHLEYPVSQYDNVRKGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2W5</accession>
    <name>A0A8G1R2W5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_511559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516958.1">
        <property type="nucleotide sequence ID" value="XM_025664605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2W5"/>
    <dbReference type="GeneID" id="37168007"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH59036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="318" mass="34559" checksum="8037357064F91D48" modified="2022-01-19" version="1">MAPTILIVGATGNTGRAVTETLPTLLKANESFKNHRVLGLTRSLTSPSAQQLTKIPGVEIIEKNWTDITSDWLLEHEVVRAFIASHNAPNQFAEESAFHVAALGAGVEYVVRISTTAPNVRPDCGAYYPRTHWAIEAMLGSAEFSALKWTSLQPNVFTSFYMAVLAEYIKKFKRNGELGPLKLMASKDAPVAPIDPDEVGVFAAHLLALDDPSPHSGAKYVLNGPEDITGEQLVGLVEQRIGTKVKEVTYQDLSLLDAMLDSQYEGSGQSMTVVKSIENALLIMWEGKCNASATSKEVLDIAPPRRTPTDVLEDLLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2Y8</accession>
    <name>A0A8G1R2Y8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_512370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516215.1">
        <property type="nucleotide sequence ID" value="XM_025664651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2Y8"/>
    <dbReference type="GeneID" id="37168053"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03488">
        <property type="entry name" value="Topoisomer_IB_N_htopoI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoIB_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048045">
        <property type="entry name" value="Topoisomer_I_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPO_IB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="411"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="773"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH58293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="889" mass="101567" checksum="B85DADB47BD586EF" modified="2022-01-19" version="1">MSSSEDDTPLVKANGRLTSSHTDSKLRDATETNGHVDPGVSIRFGPVQAENDVDMADADAAAVPKRKSRSSVGQRKSYAEPESSEDDQPLRLTSRQSKRRRTSVKHEDPETDDDVPLALNGRKLPKASETAIGEESDSDVPIERKLASQKKKIQQKAEKDAKATRKQAPPKTTKATATKRQANGVKKEPEDVKPSTVKKTAKPTKASEKAALPSHVKRAASSAKSTPVKKEESEEAEDAEEEEYRWWEDPTKGDGTIKWTTLEHNGVVFPPPYEPLPKNVKMKYDGVPVTLHPDAEEVAGFFGGMLNATQHVENPTFQKNFFMDFRDILKKTGGAKDPKGNKVDIKDFHKCDFQPIFAYYDNQRQEKKALPPAEKKRLKAEKDAQEAPYMYCMWDGRKQKVGNFRVEPPALFRGRGEHPKTGRVKSRVQPEQITINIGKDAPVPPPPEGHKWKEVKHDQEGTWLAMWQENINGNYKYVMLAANSDVKGQSDYKKFEKARELKHHIDRIRKDYQKNLKHELMVERQKATAVYLIDQFALRAGNEKGEDEAETVGCCSLKYENVTLKPPNKVVFDFLGKDSIRFYDEVEVDTQVFKNLKIFKKAPKKEGDEIFDRLTTSALNKHLSTYMQGLTAKVFRTYNASHTMSTLLKDMKATGNIAEKVKAYNDANRRVAILCNHKRTVAASHANQMEKMSERIKGLRYQRWRLKQQMLDLEPSLKKKKGAKYFEMDEDMDMEWVKEHQAYLVEEQRQKIQKKFEKDNEKLAAEGEKEMKATELESRLQAAKDMEKKFNKENKTGKVEAEGKSPTVDKLEAAITKLEQRIETMELQAQDKEENKEVALGTSKINYIDPRLTVVFSKKFDVPIEKFFSKSLREKFEWAIKSVEEDWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R313</accession>
    <name>A0A8G1R313_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_514021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515251.1">
        <property type="nucleotide sequence ID" value="XM_025664728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R313"/>
    <dbReference type="GeneID" id="37168130"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="637" mass="69353" checksum="26B99EA63EEED90D" modified="2022-01-19" version="1">MVSRPPSPVRPSEESNGSLERCLRGPEPDREHSRSDSRETYPSQRNPITDYGSSKKYLLREVEGPPEIHGSAMKKSKAPTGLLSWGWEIGASVLSVACVVILIVLLNHLDGMPYADWAYRVSPNAVVAVIATANRATLLFPVGVCLSQLKWNHYRSQRRLYDLYALDQASQGIWGSLQLITTNRPSLATLGAVTLILSAALDPLTQQILTFPSRIVPATNETASLQTAQAYVPGNANSDNTMSLLILQSIYGSDNTQEPTCSTGLCKYPTFDTLGACSRCQDVTSQSLQSCTALSSNSSYASFFNGTAYQGARPNCTYTTPGDLRITPDIFEAATVDIGTGNAVDLEKETWSFANTDTDRLNLSSSQGPRVAGILNPIVGLAAAIYDNPNILYTAENHTALEPKPQITECALYFCAQRYTNNSYTSDHQSLEASETEQLFTKNKYFQMFYPNELAPLNSSTPSFATNGNYTIAGNTVLQILNSFTSTISLSDQIEAGWTYSVQEGKDASPVMKNVAVGITKGIRAGPNSTTITGEALTTQTYISVRWYWAAAPIVITILSILFLILIVAHTARAKGVGMWKSSALALLACRVAQGPEHPDLQTLKEAEMENVSKSMLVSWDREGEPLTLRVDGMKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R315</accession>
    <name>A0A8G1R315_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_437676</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516431.1">
        <property type="nucleotide sequence ID" value="XM_025658632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R315"/>
    <dbReference type="GeneID" id="37162034"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH58509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="319" mass="35607" checksum="E8C3A6C29F624444" modified="2022-01-19" version="1">MSSTGSCANCGNEAKWRCSGCIGAPEYTPGDALPVFYCGLSCQEAHQPVHKDHCKTMRRRKKLLRTAVIAKAAFLGYRELHFDVDVTNIERRDHNLYLSTNSMILDRNSLALGRPFPENLTTDPKHQEAVLTWLQGITACPLSCRLVTKLLAGVPCDISMMGVNVGKRSLNIQIVPRSDSVDITGPDTAGIPHHILKVRVRQPGTDETWIMDLTGAQYGIQAALTPYSKYMADQECSIVGNPEPYNMTETWDLDVASAKLEEVFREVLSSVRQPRLRFAAFVDTVDEEILKGSPEEFVHKLAQFRVALKQYMLNEPQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R393</accession>
    <name>A0A8G1R393_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional repressor rco-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_513390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515778.1">
        <property type="nucleotide sequence ID" value="XM_025664706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R393"/>
    <dbReference type="GeneID" id="37168108"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000030">
        <property type="entry name" value="Putative transcriptional repressor TUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000111">
        <property type="entry name" value="Transcriptional repressor rco-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF8">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="334"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="369"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="410"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="455"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="509"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="551"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH57856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="606" mass="65856" checksum="D0DC9CFE4E405C88" modified="2022-01-19" version="1">MYNTHRGMVPAPNSRLTELLDQLRQEFENQSRSTGEFEHQLTGQLQEMEMIRQKVYQLEQAQLKMKQDYEAEIRVLRHELESRGVQPVSSHITGPAQHAGPSQAPPPALGHGPSNLFGGIMTNQGGSGPGLPVAPPPPQDQQPPQHTLQQPAAAAQQGAPQPPQSSFGGYQPGAAVNGYGPPPPPAASPGPGKRPRAPPGPATPQQTHQLAYTSDPRVSSPQLARPTPPSQALVRDRPGNMLANWNPDDLPASQKREGADWYAVFNPEVQRVLDVELVHHLVHDSVVCCVRFSRDGKYLATGCNRSAQIFDVTTGQNVATLQDENVDKNGDLYIRSVCFSPDGKYLATGAEDKQIRVWDINARTIKHIFTGHEQDIYSLDFAGNGRYIASGSGDKTVRLWDILDGKLVYTLSIEDGVTTVAMSPDGHYVAAGSLDKSVRVWDTTTGYLVERLESPDGHKDSVYSVAFAPNGRDLVSGSLDKTIKLWELNVPRGAYPGSGVKGGKCVRTFEGHKDFVLSVCLTPDGHWVMSGSKDRGVQFWDPITGNAQMMLQGHKNSVISVAPSPTNNLFATGSGDMRARIWRYVPTGLQGVHHRPGGFLFSSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3T2</accession>
    <name>A0A8G1R3T2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_467712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516866.1">
        <property type="nucleotide sequence ID" value="XM_025662211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3T2"/>
    <dbReference type="GeneID" id="37165613"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16230" checksum="0951BE451521AC18" modified="2022-01-19" version="1">MSPTKEDIHFDDDAPILIVGGGPCGLLLAYLLAQLGRYGVNTLDDVIRSLLCERYPTRLQRGEVFWVNFITSLSGRQVGRLPYERIDPEVLESILMMIYNISQPEFEELVAKRLSKNNLVEIRKNHLFVGLVDVSYLGGYNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3T6</accession>
    <name>A0A8G1R3T6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Polyadenylate-binding protein</fullName>
            <shortName evidence="14">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_279206</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516589.1">
        <property type="nucleotide sequence ID" value="XM_025655175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3T6"/>
    <dbReference type="GeneID" id="37158577"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000004">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000355">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000384">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 13 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="52"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="140"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="233"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="336"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="17">
        <location>
            <begin position="657"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="367"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="621"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="737"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="748"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH58667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="763" mass="82374" checksum="ADA23C82D0CCCE6A" modified="2022-01-19" version="1">MSADVSTTPAAENVNGAAEASPAAAAPSATTPEVTAVENSTPAPAANQPHSASLYVGELDPSVTEAMLYELFSSIGQVASIRVCRDAVTRRSLGYAYVNYNNTADGERALEDLNYTLIKGKPCRIMWSQRDPALRKTGQGNVFIKNLDSAIDNKALHDTFAAFGNILSCKVAQDEFGNSKGYGFVHYETAEAANNAIKHVNGMLLNDKKVFVGHHISKKDRQSKFEEMKANFTNVYIKNLDSEIDDDEFRKMFEKFGEITSATLSRDQEGKSRGFGFVNFSTHESAQAAVEEMNDKEIRSQKLYVGRAQKKHEREEELRKQYEAARLEKASKYQGVNLYVKNLTDDIDDEKLRELFGPYGTITSAKVMRDTNVERESSPESAGKEKEANKENDKEATPEAEKAEEKAEEKPAESSEEKDKEAKKSDKKPFGKSKGFGFVCFSSPDEASKAVTEMNQRMVNGKPLYVALAQRKDVRRSQLEASIQARNTIRQQQAAAAAGMPQPYMQPAVFYGPGQQGFIPGGQRGMAFPPQPGMVMGIPGGRPGQYPGPFPGQQGGRGMGPNQQIPPNFAQGIPMGMQGPGAIPNGMGYPQMAQVQFGRGAGGRGQVPGMPMGQGMRGGPGYGQGRGVPVQQGQIRPGQGGRGQNAAAPAGPQEGAAGGVNAQTLGAAPPAQQKQMLGEALYPKIQAQQPELAGKITGMLLEMDNTELLSLLEDEEALRAKVDEALSVYDEYMKNKGTESEAPAAEAAKPEAEKEASTEENKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4T5</accession>
    <name>A0A8G1R4T5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chitin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_219833</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the polysaccharide monooxygenase AA13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518023.1">
        <property type="nucleotide sequence ID" value="XM_025654678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4T5"/>
    <dbReference type="GeneID" id="37158080"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052282">
        <property type="entry name" value="Starch-active_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575:SF2">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034112523" evidence="7">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="8">
        <location>
            <begin position="20"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH60101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="299" mass="30420" checksum="0279402EEB4075F2" modified="2022-01-19" version="1">MKQAGSILALAGLVSLAQGHGFVTSPQARMPGSAMEKACGQQVYNNQEADNYGNVQGELQIASGQSDYDADACDIWLCKGYKYADNKDNVYSYKAGETVDFTVDIRAPHTGTANVSVVDTASNTVIGSPLIYWSVYASTSTGVTANETSFSVTIPDDLGDKCTEGGACVLQWWWNAASIDQTYESCIDFTVGGSGSSSSSSSSSSSSSSAAASQQTTTTAAAAAVTTPGTANNVAPASSSVPTTLATSVKQSATVAPVAASSAAAAASSSGVSIPTDGTAEEQLTWVASLLKALLKYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R545</accession>
    <name>A0A8G1R545_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_437585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516331.1">
        <property type="nucleotide sequence ID" value="XM_025658624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R545"/>
    <dbReference type="GeneID" id="37162026"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034179589" evidence="2">
        <location>
            <begin position="20"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="209" mass="22749" checksum="E8FBD728BBDECD35" modified="2022-01-19" version="1">MKQLFLFLGFLALFTLSSATYAKTCASVPPFPQTYISPTSISPNHTRHQMQTPRHNPNLGQTQPTTQGQVLRNFYNSRGQFQGKGCNGTAPCRFSVSFTNASRLQYCKSRPNCTNDGNEYTKRGPARRDVEAEGGTEFYRLESGMVLFAPGGLEIGEVVYRTGVGNWTVFEDGGGEGGNGDGDQDALGDDDSIQAEEDRVVGVVDGWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R585</accession>
    <name>A0A8G1R585_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methylenetetrahydrofolate reductase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_250550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517725.1">
        <property type="nucleotide sequence ID" value="XM_025654927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R585"/>
    <dbReference type="GeneID" id="37158329"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="10">
        <location>
            <begin position="303"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="593"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="603"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH59803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="626" mass="70151" checksum="DC759CB674941415" modified="2022-01-19" version="1">MHIKEKLAQNEAAGRTGISFEFFPPKTAQGVQNLYDRMDRMHALGPSFIDITWGAGGRLSDLTCEMVNVAQSVYGLETCMHLTCTDMPQEKVDAALQAAYKAGCTNILALRGDPPRDKEAWEAADGGFRYAKDLVKYIRSKYGNHFDIGVGGYPEGADDNPDVDQLIDHLKEKVDAGASFVITQMFYDTDNFIGWVKKCKDRGIHVPIIPGIMPIQTYAAFIRRSNWTKTRIPPDWLEALEPVKNDDAAVRDIGKRLIADMCRRLIAAGINHLHFYTMNLAQSTQLVLDELNLMPSEETPLQRALPWRPSLGLNRRAEDVRPIFWRNRNSSYIARTQTWDEFPNGRWTDSRSPAFGELDSYGIGLKGTNEQNIKLWGEPKSLRDLTHIFVDFLEGKLARLPWSDTPITTEANAIKTSLIDLNQKGLFTINSQPAVNGVKSSHPVYGWGPKNGYVYQKAYLELLVPPYLIDELIARIEKNGDLTYHAVSKTGELRTNTRDSPNALTWGIFAGREIVQPTIVETVSFLAWKDEAYRLGDDWAKCHDASSPSRKLIQGVMDNWHLVNIVNNDFHNTSNLFNLFKDLDVRELDTEIPVENGEPKAHTNGATNGTTNGATDGAAPELAVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5C1</accession>
    <name>A0A8G1R5C1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_458154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516873.1">
        <property type="nucleotide sequence ID" value="XM_025661564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5C1"/>
    <dbReference type="GeneID" id="37164966"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH58951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="492" mass="55603" checksum="32F2FF63610875CA" modified="2022-01-19" version="1">MGGIPFTSRACAACKKRKIKCDLEKPECSNCVKRGGTPCPGYQDRDFIHQSFEPRGARDAEIKLPEARRVGELQLLALPACFNLNPEARTQLFATYMHTFFASNPSPTGRVDSWYSLMARFPTLAGKSDLLDRSVIGLASVFLGKKTRDGRLAHYGLEIYNSALHAMLQILQVNRPPTATTLYSAIVFQAYETMENSETVLRNCLAHIQGATAMLKQHDFTRCDQTLIDAILWRHKWAAAMFTLNTPYSMHVDVECLNLGRKDSPVDELFEVIAEGIALRRDLCKLIGQSQHDREHACHALLQRCFNLEARLRVDWLHMSAHRLDGKPTPCSRQSLGQEPSMLPLDPDLAPYNFESLEAAKIYLLFWVASLVIRRVIYQTETHLLRDPDPSRMVFYAREICRSVAYCMQPENRMLAVRSVLLGLSQASKCYIDCGDKAEFEWCQAVYPFIDASGFGIARLMSKMEWKFWNAAQSQPRGAPLLLPEAVRASSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6V0</accession>
    <name>A0A8G1R6V0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_487492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516707.1">
        <property type="nucleotide sequence ID" value="XM_025663458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6V0"/>
    <dbReference type="GeneID" id="37166860"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="176" mass="20483" checksum="A30C6FD13041EE1C" modified="2022-01-19" version="1">MKYEIRDNHNTIALLRQWFDTIDPKTYRKQNPWSGELTDAYEHYKYLDKIFIQRKAIYMNEPLLTLEATPDQHVKSIQLAIEWGEAALSSAKARIHVLANYRNAYDVTVIHSHIEEAERHLFSAMSALREARTNFQVAKSDYKFPLPSVLCQPDLYPHYSTSFIDLCLGVHVDPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7C2</accession>
    <name>A0A8G1R7C2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_449194</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516012.1">
        <property type="nucleotide sequence ID" value="XM_025660112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7C2"/>
    <dbReference type="GeneID" id="37163514"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.920.10:FF:000004">
        <property type="entry name" value="Mitochondrial chaperone Frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH58090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="221" mass="24586" checksum="E8FA24C7FF2E1FB3" modified="2022-01-19" version="1">MNPTMYSRLPRAILSPAAATVARPSLRVGARFATATPFLLQPQPQPQPQLPRRCFHATSAPRKGIFPDSADPPAPHPESSNVAGAATHVTEPSPLTDAQYHEHAEHYLDVLQYEIEKVQEEGSDIEAEYSAGVMNISVPGVGTYVLNKQPPNKQIWLSSPISGPKRYDWVVEGDQMHEKQESRPFINGQWIYLRDGSNLTDLLNHELTLNLPKDVYSEVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7D9</accession>
    <name>A0A8G1R7D9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cucumopine synthase C-terminal helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_368635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517007.1">
        <property type="nucleotide sequence ID" value="XM_025655876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7D9"/>
    <dbReference type="GeneID" id="37159278"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040602">
        <property type="entry name" value="Cucumopine_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18631">
        <property type="entry name" value="Cucumopine_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cucumopine synthase C-terminal helical bundle" evidence="1">
        <location>
            <begin position="175"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="337" mass="38546" checksum="858B0B90F7075453" modified="2022-01-19" version="1">MRIPNGSQVQHLNEVKIKWPKLNTTITVKINDASPTLVGLLETALPYRSLQTHAVVAGDQLYHLIPSEQLIYTPADKKAPDRAKEPDGSVFLSSFQHFVIKYGEVTEHQPVATCGKVIDEDMDKLRWVADEVWKCQCETRKHPIEVVLWDASKPEPDPNKLDLFRHQRAGVSKEVRKLVDEIHTETQKCWSDISEDIEKNHCGKAPERPGSKESYFGAMVFSNSVIRTLGYHVLDNIIKLAFTRPEFTLRHLIVLFRDFVPSIADFVGHLGAAYVNDSYESIEKLIKEKVEKNPNQEEAREDFLAMVSALSFYVNLLNAQNLHMFPWRHAKEYPIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7N5</accession>
    <name>A0A8G1R7N5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_447279</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades free oligosaccharides in the vacuole.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518629.1">
        <property type="nucleotide sequence ID" value="XM_025659689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7N5"/>
    <dbReference type="GeneID" id="37163091"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10812">
        <property type="entry name" value="GH38N_AMII_ScAms1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000001">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="10">
        <location>
            <begin position="556"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH60707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1089" mass="123249" checksum="CC185C9B1CBAF911" modified="2022-01-19" version="1">MGGDVPRQAPSALPQTPAGPVGQRIKSIYTDRLKQFTATGQYEGQNLISKLNEAVNSDEDHVKLSVYSVPDLQRPTFKEATSNEFKPTHIGASFGPSWSTHWFRIRLTVPEDMRKKERLEFHWDANNEGLVWSEDGRPLQGLTGGNERIEWIIPDAWRDGKEHTFYIEMACNGMFGNAPGGDSIQPPNPNKYYTLHKAQITAVNLEARALFYDFWIIGDAAREFPGDGWESHEANMVGNAIIDAFIAGEGSNESIREARKIAQKYLGSKVDSSRVYETDTEPIVYAIGHCHIDTCWLWPWAETKRKVARSWSNQCDLMDRYPEHRFACSQAQQFKWLKQYYPSVFERVKQWVKKGHFQPIGGSWVEHDTNMPSGESLVRQFLYGQRFFERNFGERCTTFWLPDTFGYSTQIPQICRLAGMSRFLTQKLSWNNINNFPHTTFLWVALDGSQVICHMPPAETYTASAHFGDVKRSVTQHKSMDNDNTSLLVFGKGDGGGGPTFEHLEKLRRCRGLSDKVGLLPRVKMGNSVDDFFAKLEKKVEQGTRFATWYGELYFELHRGTYTTQANNKRGNRKSEFLLREIEYLATLATLEQSADKYKYPKEEIDEMWEDVLLCQFHDCLPGSSIEMCYDDSRELYKKVFEIGNKVRKEALQALGLGSSTAKGLVAINTLPWPRSEVVKVPADFTAAGGPRYAIVSGESGPIKCQIPTASSRAPAVTVSEIEPGVFRLQNEKLRVDVHDGVITSLYDLEEKREIVAKGGKANQLVIFDDKPLYWQAWDVEVFHLESRKELQSGKTTVAENDPYRVSVVTETRISDKSWVKTTISLAAAVGDQPSYVEMESEVEWRETMKFLKVEFPVDITNTQASYETQYGIINRPTHYNTSWDMAKFEVCCHKWADLSEHGYGVSILNDSKYGFATCGNMMRLSLLRAPKAPDAHADMGHHRIRYAILPHAGPLDHRTIRAGYSFNHPLALEPVSGQEASDAFKSILLDGSPSLVLDTVKRGEDDEDVSRDELPRRAGKSVILRIYESLGGKSRGTINTKLPVKKAWKCNILEDDETSLVLSKSASQTTSIDIELRAFEVATYRLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R810</accession>
    <name>A0A8G1R810_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dual specificity protein phosphatase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_435560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519195.1">
        <property type="nucleotide sequence ID" value="XM_025658533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R810"/>
    <dbReference type="GeneID" id="37161935"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dual specificity phosphatase catalytic" evidence="1">
        <location>
            <begin position="105"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="311" mass="34826" checksum="F0ED9AA1A8920641" modified="2022-01-19" version="1">MAQPYHPAELPMSHSANAHYTATQEYSSRNSSQQPSVYTWSPLGVGNSNLRDTDNPAVHQFPEGKFVPSGFFDKVDINLFKDTLSQSVDWRYEKRRQVHQILPFLYLGPWSCLADRDWLNQEGITLLLGIRHSQLAKAGLLSGAKAAAALNIMTASVDYQDNQELISNLPDVIYGINEHIASSVPLGLSRSIEKKVLVFCETGNQSSALVVMAYLMVMLNISPMRALDLVQSQRLSVIVDGPASQLLLAFEAIIMAKRDVERVRRASILDTSASSKKRTNSRDTDDMDIDEIEFWDLERKPLPPFQDRSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R878</accession>
    <name>A0A8G1R878_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-ketoacyl synthase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_446516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519285.1">
        <property type="nucleotide sequence ID" value="XM_025659520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R878"/>
    <dbReference type="GeneID" id="37162922"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-ketoacyl synthase-like N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH61363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="68" mass="7463" checksum="973245E93B276065" modified="2022-01-19" version="1">MQTSNFEPIAVIGFGLKLPQQASTPEGFWDLLIQGRSARTETPADRFNAEAFYKATATGDRQRVGTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R882</accession>
    <name>A0A8G1R882_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_448554</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516462.1">
        <property type="nucleotide sequence ID" value="XM_025659966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R882"/>
    <dbReference type="GeneID" id="37163368"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH58540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="400" mass="43906" checksum="4802BD80A5F9FB81" modified="2022-01-19" version="1">MATSFGLAQFIVARVVLGLGTGGYVATVPVWQAEISQAGKRGAHVVTDGIFIGAGITISLWIDFGFYFVTGNSVSWRFPLAFQIVLSLMVMAFIIFFPESPRWLIKRNRTEEAREILAALADVDPNDESITLAMRDIERSLALSGSGSWKDMLSMGEQRLFHRTVLAAAGQMFQQMCGINLITFYATTIFQQYLGLDAIPSRILAAAMCLTQPLGGFLAFFTIDRLGRRVLMLWSAVGMSASMAILAGTTSRSDDTAALVVAVVFLFVFEFIFTVGYSGLTFLYATEVAPLQLRAAISAVSTAAVWTFNFLLAEVTPVGFDTIGYQYYIIFAVLNAVIVPTVYFFFPETNGRSLEEIDEIFLQSKSVFDPPRLARTLPRMHLAEVVDDPEDVADAKVGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8R1</accession>
    <name>A0A8G1R8R1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear distribution protein RO10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_108779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519491.1">
        <property type="nucleotide sequence ID" value="XM_025653837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8R1"/>
    <dbReference type="GeneID" id="37157239"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061640">
        <property type="term" value="P:cytoskeleton-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009991">
        <property type="entry name" value="DCTN3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07426">
        <property type="entry name" value="Dynactin_p22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24043" checksum="2F6BADD9908B6D38" modified="2022-01-19" version="1">MTLENDAVAGATIELLETRLRRLTYLLTGDANWTGNPTPPAKPASLDDSVSRRLLRLERDLEKLSRNIPAVRDVLSLHDRFPDLFRQTPSKSLPENLSTQNLASIVLSYASAFPETASRLTSLNDLPIPDAETSASLIQLQPRLDQLAQTQEDQAKQISELRVRSARVLQRWYEVALVSGGECWAEWEGRLEDVEREVKREEVVRERRAKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9P1</accession>
    <name>A0A8G1R9P1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux pump antibiotic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_390894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519078.1">
        <property type="nucleotide sequence ID" value="XM_025656789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9P1"/>
    <dbReference type="GeneID" id="37160191"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="253" mass="29259" checksum="C0E0292AEF40AA09" modified="2022-01-19" version="1" fragment="single">MSTPQDRHPELFRPVNSESPRGKKRTVPLQVLCLGFNRTGTASMCSALETLSLPCWHSIHLMSDKFGTIPMWQEAIDRKFFNAPGPLYGRAEFDQLLHDYAAISSDTPAIAFSEELLNAYPEAKVVLVERDIDSWYQSWMNGVIANTYDPIVTIIYTIDRWFTHPLGKVHKSTFEGWLGIKGPEDAKRVSREKYKEHYALVRRLTPPERLLEFRLSEGWEPLCEFLGKPVPEVPFPHLNEKKWLDEKVKIVMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAF6</accession>
    <name>A0A8G1RAF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF6 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_414057</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518762.1">
        <property type="nucleotide sequence ID" value="XM_025657631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAF6"/>
    <dbReference type="GeneID" id="37161033"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="8">
        <location>
            <begin position="91"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="436"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH60840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="478" mass="52105" checksum="A1CC8BB5DC105C89" modified="2022-01-19" version="1">MSLNPSDARGVNSTAGEETQQQYVTLLPAQNNQVDEQQQQQHVVYSEQTPLLHSGHGHVSASASSTMQHCLTQPWWKTAQQVSCDVWLQGKGMILVMFAQFFGASMNVMTQILEIKGRDGKGFHPFQILFARMSITVLASYLYMWYARVPHPFGTRETFTLLMLRAGGGFFGVYGLYYSVQYLPLSEATVVTFLAPILSCYACSLLIPNETFTRKQQLAGLVSLAGVVLIARPFPFMRSGADSEEPEQGDKPGATDSYHHVLAIVVAAVGVLGASCAYTTIRMIGQRCHPLVSVTYFSSFTTVVATLAMLVMPSVPLELPGTLWEWTLLLGLGVSGFLLQFLLTAGLAYVPPVRKTKPKTSVDWDRDYGTRDDEEEASAKPTSSGSRATFMLYTQMLFAVFYDRAIWGSTLSAVSWAGSALILVSAMYVAMAREGAKGTASEEKEGGDQEGTDENRAGVAAEARLEEGGERQQSGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB45</accession>
    <name>A0A8G1RB45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_411368</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521338.1">
        <property type="nucleotide sequence ID" value="XM_025657519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB45"/>
    <dbReference type="GeneID" id="37160921"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000028">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
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        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052814">
        <property type="entry name" value="Peroxisomal_DnaJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006:SF1">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH63416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="472" mass="52966" checksum="798F5CED229AAB24" modified="2022-01-19" version="1">MVADTSYYDALGVPPTATELEIKKAYRKLAIIHHPDKNPGDETAHARFQEIGEAYQVLSDEELRKRYDKFGKEDAVPGGGFEDPSEFFGMIFGGNAFVDLIGEISLMKDLTTTMDITMQQMEEEELAASAEEKLNIHDEQEHAEGTAEGAAQAASTPAESTTAASEKPAASPSSGTSTPRRYMGQQAIMDKSEEEARMEAAGLSQEEKELRKKEKKKGGLSREQQERLAAYELERKKAREERVNTLATKLVDKISVWTETDKSPEMTRAFEEKIRLEVENLKMESFGLEILHAIGATYVQKATSFLKSQKFLGISGFFSRLKDKGTLAKETWTTISTAIDAQMTMEEMAKLEERGGEDWTDEKKAEYEKKVTGKILAAAWRGSKFEIQSVLRDVCDQVLGDKRIKLDKRVERAHALVIAGNIYSKAERDPDEEGDFMAFEQLMAESMTKKGKEDKKKKKKHEHHHEEPTATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB63</accession>
    <name>A0A8G1RB63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_483866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519764.1">
        <property type="nucleotide sequence ID" value="XM_025663193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB63"/>
    <dbReference type="GeneID" id="37166595"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH61842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="137" mass="15538" checksum="7A2703B194EC6B95" modified="2022-01-19" version="1">MVFKEPRVSEHEPALRPVPVPYVEWDLNNEPSQVQAGTPFIHLGFVLVELSQCQTLEALKKGEDHDEVQIVANRNTALRLLPLVEAKSGQSYRQVTEQCLNWQNCTLDNDNISKAVRSITAPLVGYWRILKGTEHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBF3</accession>
    <name>A0A8G1RBF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Allantoin permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_113721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519571.1">
        <property type="nucleotide sequence ID" value="XM_025653857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBF3"/>
    <dbReference type="GeneID" id="37157259"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="554" mass="62355" checksum="368458C804D9ED26" modified="2022-01-19" version="1">MARFGSRVVSALELESSQDSRWSNEDLLPTPPEQCTWRWWNYVSFYWSISFTNWTLGSTMIGIGLNWWQSIVVIFVSQLISSVAMAFNSRAASVYHLGFPCVGRSVFGMWGSYYFVGARAVLAIVWFAIQMDFGAEYMYNILRAIFGHHYTDIPNHIPSSAGITTQKMLAFFLCWLVHLPFCHFRPYQLRKFFIFKTFISLPAMFGLFIFAMANTKGQLGTMYTAEARSTTATAWMIIAGINSGLGNTATLITNQPDYCRWTKTRNAPLWTQLLSNPIAVTLSASLGILATAAINNKYGTDIWNQWDMMEFILDHYWSGTTRFAVFLVAFAWLVQILGTNIAANMISFGADSSMLFPRFINMRRGQYIVQTLAWAVVPWEILTSATKFEDFLSGYALFMGAVVAIMVCEYFCFAKGNIFLSSLYDGTKLNKNYRYYGGWNIQAVIAYIIAIALPFPGFVGSLGASVSITATRMGDLGWILSFTTAFVMYYIICTFWPTENQKLIKKQGLTWEQTAQDTDPQDFYLNGAGLGGADEPVAAHQQVVVEKGVVEKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBJ6</accession>
    <name>A0A8G1RBJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box and WD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_391239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519317.1">
        <property type="nucleotide sequence ID" value="XM_025656798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBJ6"/>
    <dbReference type="GeneID" id="37160200"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF2">
        <property type="entry name" value="F-BOX AND WD DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11400)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="978"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1121" mass="122102" checksum="87B1F342783BCC11" modified="2022-01-19" version="1">MQSEPTAVFDRSLSVDPSLDVPFNSTQHGNDSHGEHPVSGLRHQKSGDSSVGHDSCDGGQQSPLKEADPAPFNDTVSQYEHTVAPLIQKEEGVKSRKKQPSIYSGLSLEAFPNEVLTHILSHLPPPSLSSMALVSRHFHGLVTTPHAWRIAFSRYFPGPYTIEDGAWLSAAKSSETVTSDKRYFSRLTALASWRSEYIMRTRLLRSLSRGKPAQFEPSKKTGTVRAASVRNGSAVATYTSQLLFPVSHLHGSFGSEVKKKEPLFIHGASEQGFASASDPSTVKVGTWGLSDHQFFRHFADLFPGDAEYGLGSGDHVGAPNRMDVSQPYGMIYGEACPQGRTYFISTTEQRGRFLGIADSSSQPSLGIPALNLIATGVTAVWIAKSSNILKMTGGLVAMLSGSSTGVLTSYALGPHPTYEKRYERGQVTARWVLCPGVPIISISVDDSYSPKRHSCRRIWATVLNALGEVFYLSDLPRQPDVPTTKLSPEEYEQLAWKTGRSVRWELVELSRRIARLDPFSRDSVDGSYSPRSSSDAMKLNEEQIAAETKEIERFLSFKPKHFRKVCEGWDMRRELKVDFAGDDGHGAGESFLVINRGVGDDEKASIRRYTRKMTRHASTTMHGSHNVENVPVPSIFGGPVKSPILSFVSSSSTTAPSRASSGLSETVCSISNTEWRITDFDFGDRKSVQITTSALDLSTYALLTIDEDPLIGMSGSSALSSATSSPLPHMKQSPGNAEVPGQRGRYLAVGTAAGTVFVWDIRSPTSKNAEAINHISPIRIIQTESPQVSCVALTSLYLVHGGNDGLVQAWDPLASSTRPIRTINSRFSTRARRRLVQAEASIHGVGNNYYATGAICLDPDPTVLRGMVALGTHLRYWSYSSTGADQYKSSKRRLRRGLRGINSTPEGQRFNTSGRGALKDYIEDEKVEMERQKIADEKERAHLSHRFGVDLLGPDVDEEQLLAYAQLLSQEAYSSEAHKRGEAIESSAVSTSPSDTIGPNDSSVAPDELSSASSPYEDFADGDDPDIAEAIRLSLLEDNKPGMDLDTDTGPFDPPSPSLLGPAVAESSRQQEIDDLEFAIQLSLAEAESHSGQHHPTEEFPALSPWAQPSPAGKDKGKGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBQ4</accession>
    <name>A0A8G1RBQ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine-rich secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_495037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521156.1">
        <property type="nucleotide sequence ID" value="XM_025663899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBQ4"/>
    <dbReference type="GeneID" id="37167301"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034365091" evidence="1">
        <location>
            <begin position="23"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="340" mass="36243" checksum="F620B872B2F141A7" modified="2022-01-19" version="1">MKSYSLSLVTTIFLSTASLATAKTYTTNVPVKEIQGTSSIQGNSITWVEDGFKTSIDCDNQGENKKLSLSDSKKYAGCCLPGQRLVGSPETAFDCCAEGHDLAGSKDRGYICCPEGQTYDGATCQAAEPVCENGKMLKNGECVCPKGTREDDDGTCVPVKCSSGLETGKCYTFRGDNGNLLGFGGGYYSAAPESIALKSGRFKLCKEEECKTGEAINPADQVYIMDIHGNPPNGAHANSWLNSAKNGAHVGKTANFALAGKFSVTKWPCGKYCLGGFDYGLGPACPSKTPAMTFYQNDKQACIPFEFTEVPCDVKAQENNCIWKNNEDQCCGGAVDCRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCM8</accession>
    <name>A0A8G1RCM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_483271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521345.1">
        <property type="nucleotide sequence ID" value="XM_025663147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCM8"/>
    <dbReference type="GeneID" id="37166549"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="116" mass="13239" checksum="6BF08088C531E7DE" modified="2022-01-19" version="1">MAAIEYPSTPASIPLHHHQATMEASRSSDGERRRKEENLAKAKANVQRIIQLYNSGKPLFTRTLLKDLHEQIVQGKDKVKIPTWNDEAKTYSLKVPKDLAERWQVQSAPIRHSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD18</accession>
    <name>A0A8G1RD18_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_483451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521540.1">
        <property type="nucleotide sequence ID" value="XM_025663160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD18"/>
    <dbReference type="GeneID" id="37166562"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="496" mass="55155" checksum="56000F7812BFEB01" modified="2022-01-19" version="1">MQQANTSSKPAGRSSYSSSLSYPTKKPRLVSTVQESSPAAHDLARIKHELLEKADWATVAAARPLTVLFPPVEALQRFGRRRKITNDDRERLGSSVLRPKLTYRPKHRRGAESEESIQDLDIRINGQPVGANYPGFHGPPTDATSQSMLLDQESPPTTPKPLVHEYVYENVGVRSSIGDRSWILDSSSIPASCVSSSERGLSTQGNSIVRDPDYLVDNSPGKEQFQVTGSEALQSADTSPKVQEAGTPIRRRFTIDDQILAEEEWIKAAYGTSLERDSYSTAHHFSQSLLNPELSSPTANDSRRQMSAQESMSTSSTLNHSSYGWLPEPRHNILRVMSQKTDKGQIDKVPSESRLRSTRLAPLSRKPTTPPLIIFGQAVDLDGSLFATSKQVEHGKQQAQHDFTCSATTFREANNYISTDHYPFETNLRRPDDFAFSPNTVKFSKVTVAPRTGRIYIDQACASPLSRTAGPERTFPGRHAEDRPAQEWTNRRSLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1REA2</accession>
    <name>A0A8G1REA2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber evidence="11">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO85DRAFT_444888</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="11"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521583.1">
        <property type="nucleotide sequence ID" value="XM_025659134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1REA2"/>
    <dbReference type="GeneID" id="37162536"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000005">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 17" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="19">
        <location>
            <begin position="24"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="16">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RAH63661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="178" mass="20149" checksum="AEEC351361AA9341" modified="2022-01-19" version="1">MKQQQQQAENAEGAAGKKKKKVTAAQLRVQRDLQELTLGSTMKMSFPNPDDILNFTLTIEPDEGMYKGGAFHFNFTVNQNFPHDPPKVKCTQKIYHPNIDLEGNVCLNILREDWKPVLNLNAVIVGMQFLFLEPNASDPLNKEAADDLRQNREAFKRNVRTSMGGGSVRGIQYERVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RHW3</accession>
    <name>A0A8G1RHW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_444858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521547.1">
        <property type="nucleotide sequence ID" value="XM_025659127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RHW3"/>
    <dbReference type="GeneID" id="37162529"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034711465" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="53" mass="5724" checksum="C55283DDA1CD69F9" modified="2022-01-19" version="1">MLAINLSILCWISLVDASIAASSPRSDGGWCTPIGWVPRNGKRRAERLGGTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VFV3</accession>
    <name>A0A8G1VFV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="7">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_433133</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="7"/>
    <dbReference type="EMBL" id="KZ825098">
        <property type="protein sequence ID" value="RAH51649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509571.1">
        <property type="nucleotide sequence ID" value="XM_025658407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VFV3"/>
    <dbReference type="GeneID" id="37161809"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000045">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.270:FF:000002">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="14">
        <location>
            <begin position="33"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH51649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="626" mass="69655" checksum="1D64998D7EF1100F" modified="2022-01-19" version="1">MPMLKDPSQKYKRFQPLHLPDRQWPNKTIDNPPRWLATDLRDGNQSLPDPMDGQQKLRFFKMLVDIGYKEIEVSFPSASQTDFDFTRSLVETPGLCPDDVWLQVLSPCREDLIRRTVDSLKGAKKAILHIYLATSPCFRRIVFNMDKQKSLEMAVRCTKYARSITKDDPSTAGTEWHFEFSPETFSDTEPEFAAQVCEAVKAAWEPTEKDPIIFNLPATVEMSTPNVFADQVEYFCRNVSEREKYVVSIHPHNDRGCAIAAAELAQMAGAQRVEGTLFGNGERTGNVDLVTLALNLYTQGISPKVDFSDINAVIKVVEESNKIPVNERWPYGGQLVVCAFSGSHQDAIKKGFKLRETAGPESKWEIPYLPLDPEDIGRNYEAVIRVNSQSGKGGAAWVILRSLELDLPRALQVEFSKIVQRRTEEVSRELRPSEVVELFQEAYHLKSNPRFNLVDYNITTDRSQSPAPPEPGKALNTKNLKRRFTGVIEIDGIQHAITGVGPGAISSLAHALATLGIDLDVVDYKEHSIGLGRDVKAATYIQCTAAGSKEQVWGVGIHQDVVQASLIALLSAASSFLTSRSGSPAPFRPIRSNTLTDDDLQALEMLNGPNKPKVDIEALTQQAESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VFZ5</accession>
    <name>A0A8G1VFZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc-binding oxidoreductase CipB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_464560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825096">
        <property type="protein sequence ID" value="RAH51696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509618.1">
        <property type="nucleotide sequence ID" value="XM_025661995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VFZ5"/>
    <dbReference type="GeneID" id="37165397"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="12"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH51696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="364" mass="39156" checksum="FDCD23CE7F2842AF" modified="2022-01-19" version="1">MSQNRAAWIIAARSKPFTIGEAPLYKPGKGEILIRNHAVAVVSDRFNMPFNPIGFQLTSSDLCKNPVDWKIQESSLYLNTFPFILGRDAAGIVVDIGEGVTQFHRGQRVIAHLHSPRSGNSAHAAYQLFSLASQTLAAPIPFHISFEQGAVLPLAISTSAAGLYVPEYLNLPLPSDTPESRGKTLLVWGGASSVGATVIQLAVASGLHVVTTASHANYEFVRSLGADDAFDYRSPTVVMDIVTRLRHVDLCGVYDAIGEDKSFTRLAAIAERLQKRIPAVSVHPCYTPTVFFHPKYVTSYGIAYPPNERIGEAIWGAFVPHALATGQLKAKPDPVVVGHGLGNIPNGLDSQKAGVSAKKIVITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHF4</accession>
    <name>A0A8G1VHF4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_429454</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511236.1">
        <property type="nucleotide sequence ID" value="XM_025658250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHF4"/>
    <dbReference type="GeneID" id="37161652"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034167822" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="112"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="183" mass="18531" checksum="FD2DC529D9E6AA87" modified="2022-01-19" version="1">MRFTITAASLSLISSALAITITEPTSGTEWDFSTPKTIKFTSDANDPSVISIILRTQDGSFQTKLADNVKTSTGEYTTQPNPSISNGSDYEIEIIDSSGELAVSPTFTVEKGASNDGSTTSTSTSSSSSTGTTLATSASSTSGSNSTAATTTAQLSTGAASSTFNAPQGLVALIGAALALLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHH7</accession>
    <name>A0A8G1VHH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_346911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510159.1">
        <property type="nucleotide sequence ID" value="XM_025655474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHH7"/>
    <dbReference type="GeneID" id="37158876"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="67" mass="7123" checksum="5DFFF12D5D624C34" modified="2022-01-19" version="1" fragment="single">LDGPINTDGDYTGTSRPFSSSTGFSMDEEENTRRGGAVGHPLAQPVSIPATNGLRYNTQQPAMQEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHP6</accession>
    <name>A0A8G1VHP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_453951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510354.1">
        <property type="nucleotide sequence ID" value="XM_025661168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHP6"/>
    <dbReference type="GeneID" id="37164570"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001">
        <property type="entry name" value="OS01G0253100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001:SF931">
        <property type="entry name" value="OS11G0664100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH52432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="255" mass="29003" checksum="41F15C25B3854822" modified="2022-01-19" version="1">MSYNDDSELIGLGRVGRVMRIGHMAVKTANVWTVPKGASVTTIISYEQTTELNKQSLKHEGHVYSHIGHVPGVIKPYHISDTEIRMPYLRQGSLSRYLHTHHDTVDNSRRLQWLQEAAHIIHRVHERQVLVVDIAARNFLLDEDLSLQMCEFTESTIVADNEDMAIFVSEDFASVRSDIARFGSMMYEVISGKQFEFYVIPDIETDLDYDPVSKTYKTWPTMTNSQIRTLYSLDISSSDAGPGKDSSQCRKFATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHS6</accession>
    <name>A0A8G1VHS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS monosaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_428890</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511641.1">
        <property type="nucleotide sequence ID" value="XM_025658226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHS6"/>
    <dbReference type="GeneID" id="37161628"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="49"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH53719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="542" mass="60322" checksum="FF583D9E6634759F" modified="2022-01-19" version="1">MGVETSVDHGENISPAVAPQQHSSQESFQKPLGGVDTPVPRVTLRAFVMAVFVSMGGLLFGYDTGQISGFEQETDYLRRYGMQNAQGEWYLSDVRSGLLTSLLSIGTLVGALVAAPIANKVGRKWSITFWCVILMVGLIVQISAPSGNWVQMVMGRWTTGLGVGACSLLVPMYQGESAPRHVRGAMVSCYQLFVTFGIFLAYLINLGTNTLEGTAQWRITLGLTFLFAIVLGGGMAFFPESPRFDFRHGRVDQARATMAKLYGVPENHQVILQELDEIQNQLEAETGSEKWYEFLTAPRMFYRICLGMALQTLQQLTGSNYFFYYGTTIFKGAGLSDSFVTQCILGAVNFACTFGGLYTVENFGRRKSLIFGALWMFVCFMIFASIGHFMLDVAEPENTPGVGKGMIVLACFFIAGYAMTWAPMVWTITAELYPSKYRAQGMALAVAANWAWNFLIGFFTPFITSAIDFAYGYVFAGCMFVGAFVVYFFVMEGKGRTLEELDWLYVNKIKPWKSSNFEIPALHSFQYEEERKQSRSYHAENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIN4</accession>
    <name>A0A8G1VIN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_432643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509815.1">
        <property type="nucleotide sequence ID" value="XM_025658388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIN4"/>
    <dbReference type="GeneID" id="37161790"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH51893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="235" mass="25958" checksum="7C261A5EE1602FF3" modified="2022-01-19" version="1">MCLTLTTKHPLCGCLTTTTFTPCRLIPWNRCLRREMIIVEGTRRRNNLLCEACSDSSSRYSERRMNRLCTLMTCLEGFDSDVEFAGLDVDDEQHGQDDGVQEFRLGEHDGYNNGDGGSGGSSDEGWYGDGDGDGDGEEGDEEEYIDESSSSSSSEEELVVLRCDLSRVCDSIASSRVCHGAGVMGREKRRFGRGRVRGPKRRDTADEEAMEMDMAMARARVVDERGSSISTVSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIQ8</accession>
    <name>A0A8G1VIQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_153916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511434.1">
        <property type="nucleotide sequence ID" value="XM_025654169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIQ8"/>
    <dbReference type="GeneID" id="37157571"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="44"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="302" mass="32822" checksum="EC9D4D6FF7D9036F" modified="2022-01-19" version="1">MTDHSAAVKVVTCFLLIVSFIAVVACLTTNWQVLRRKVSSVALLLSTLIASIASGAAVSVAATHGLGQESPLSDGQVVVMQKALYSMEVLYVLTLGLGKLSVMVLFYSLLSSTGQSKSVLAATGLLLIWVVVMAIVVCLQCHPPEVWNIVGGKCLDLSGIWIAFGVMNVLVEIMIIAVPSFIIFRLQLSLKRRLVVISCFGIRILDIAGSIVQLCYVRNFKLHADSPLPTNVWQWAICSQVLQTVAILSACVPYLREFLESFPSGMFKPTELKHPTVQSAYNATKCSDSDIELMRPESTKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIW4</accession>
    <name>A0A8G1VIW4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_503710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511599.1">
        <property type="nucleotide sequence ID" value="XM_025664249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIW4"/>
    <dbReference type="GeneID" id="37167651"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="48"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="548" mass="61512" checksum="824ED153763C12AB" modified="2022-01-19" version="1">MANTGEYFHTVLPFDGHYIRLLKFESTALEEPLRLSLKTCKFAEKPDYNSLSYEWGTTAADQPILVNDQLFFIRENLYKFLKVLASSAYRDTYFFADAICINQNDTSERNAQVQRMGDLYAQAENVLVWLGPATAESDLIFDVCFESVVNNTSVLSKLGKQKAQTDALDTIYQRSYWSRLWIIQELFLARTIILFCGSKSTAWSAFKQLPKWNKREFVLGGFTGVDMVLESTPAGRHARDILDELKKRDQGRSTLTKIGLVDLILKFGLAQCSDVRDRVYGLLGFASASSEFSKAEEGRGSEVIVDYSESPMCLFVLLLRTMPREVRIGTALQLFNVLELQRAPESAIVASIPETDLSLSFEISFTHIGHLMNVTQSSDKSLHQLLAGKSFAQIQKGERQNAMAIYGGGPLYSIMSYDSCVTASGACGGDDIFLLEGTNFVLIRHYNEWGGTSGYIRGLLCSGKSEQSIQRAGEILDSFLPHLPFINGDCLRAGRHTMFKLAGPVDFVYEDLSLRQIILLLTYTGQHSDYWSRQLEASTRELMSIRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ23</accession>
    <name>A0A8G1VJ23_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_471519</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511779.1">
        <property type="nucleotide sequence ID" value="XM_025662478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ23"/>
    <dbReference type="GeneID" id="37165880"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000014">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="179"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="324"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="487"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="629"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="824"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="982"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH53857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1115" mass="124810" checksum="4016D5557337EC02" modified="2022-01-19" version="1">MDGDYTTKRRRLSPSPDDSSRTQNNSAYSVSNRNNLTDSDAAKPSRDVSTLRTSGRAKNDRSAELALASGFYKSTFFKLQLDELLNGSRPNYDKQVSRLQETLHKLKSVIECLPDRPPKSTFEAEKELRGAHGITVPFPEPRPAKDTKYTVSYSKPTNINVVGSLSLKTGAKSDVPLTVDLAVTMPSALFQEKDYVNYRYFHKRAYYIASLAAGIREAEGLNLTVKFGLQDGDSLRPVLLLEPNGTERKDSLPAKTQIRIITAIEDSLFPISRTLPSRNNIRQGSADVPVSQESTPFYNAALRSEATVAQYHKFLYNAARNCESFKDACILGRTWLRQRGLGSSPFKGGFGGFEWTVLMALLFEGGGPNGKPVLLKSYSSYQLFKATLQFIAGRDLAIPLLFSATDISFPDGTPVLYDGKRGLNVLYKMAPWSYAFLRREANTTVRMLNESRDDNFDKVFIIKVNEPLLRFDRILKLPGQDSANILRSLRSQTAVYDVIVRALGDRADLVHIYGDVFKPWPVDEKPHRKPASQSVSVGLVLNTDNAERVVDHGPSAEQKEEAAAFRSFWGEKAELRRFKDGTIRESLVWTDEKSSPSIVYQILTYILSRHFNYTKDDVVFIGDEYDDKLREGGDDVFSYSSPAFQAITDAFTSVQRSIQDMDGVPLTVRHLAPASPSLRYTALRLHGTAGVASNPADIVLQFESSARWPDDLKAIQMTKVAFLIKIGDSLKSGGVASACRVGLENESTGLMNNSFLDITHTSGIVFRLRIHHEREQLLLERQLKEKGASPLAKQQVAYALAAYKRLFIQTPRLTQAIRTLCTRFPLLSPTIRLVKYWFNCHLLAGHVNQELIELLVVRVFTQSYPWDSPSSVMAGFLRTLHVLSRWDWQQEPLMVDFGELNKESMEAIQTRFSAWRSVDPAMNTVALFVASDIDTDGVTWTQHEMPPKVVAARMCTLAKAAMKLLREQGYGLTVSDLFHTSLAPYDFVINIRPGLLQERLALPTRFKNLDARKTARTAKPAMVSSFARDLQACYHPNMLLFHGDESCSVIGGLWNPQILKPKKWTLKLAYSTCPSEPRANEEVSMNCQAVLSEIARLGADLVDNIEVHTEVASEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJG8</accession>
    <name>A0A8G1VJG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF829-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_506059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510655.1">
        <property type="nucleotide sequence ID" value="XM_025664366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJG8"/>
    <dbReference type="GeneID" id="37167768"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF14">
        <property type="entry name" value="INDOLE-DITERPENE BIOSYNTHESIS PROTEIN PAXU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="287" mass="32326" checksum="1E73163F9048BCE1" modified="2022-01-19" version="1">MLSAEFTPLSDRVYLRHGREKAKSCGKDEPTTIIIFGWGDGMPKHVSKYADGFHDLYPSARILLVLSSTLQALNQPLEARIQDMMPVIDTVFPTPTGDGSNEERVLLHSMSNTGGIFLAATITAYQKRHGADKRLPHELLVCDSTPGGLSIFTQAGRWSRAMALGTSQFFPWPCMVTQALWFAILWIHSGLGWLRGLEPSGVWADRVMNDESVTTRESNRLYMYSKEDEIIGFEDLEENVAQVRTLGYRAVDIELFEGSPHVGHMRLHPQQYWGKISECWKAAIIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJQ8</accession>
    <name>A0A8G1VJQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RraA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_104843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512454.1">
        <property type="nucleotide sequence ID" value="XM_025653808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJQ8"/>
    <dbReference type="GeneID" id="37157210"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="356"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="486" mass="51952" checksum="F304E66F325D8346" modified="2022-01-19" version="1">MFTSIFRVSFPKSVRTYSRKRMSDTTSFLDRLAALDTNTVSDALDVLHLRGATYGLRPLWNCPKIVGRASTVEVGPRIGTAPTPHPFAPTIDAVSSDDRVLVIAGGLEGVSCWGDIIANAAKAKGIRGTVIDGVCRDIDGSVEVQYPLYGRAVTMISGRSRIVSVSAGKPVRVCGGVTVEQDDYVIADACGTVFVPAAHISIVLTLAEQINNRENQMVEAVRSGQTVSAVMRDSRFEQLRQETVSAAAAASPLSQENPRKASAEDQELVGLLRGLDSPAVSDALDSLGIAGQAWGIQPLSSSGSSNRRVTVGPAFTVRYVPASDPPGSVGDFLDDVAVGDVVVIDNSSRTDCTVWGDIMTHYAALRGVAGTVIDGVCRDVDLALEEGYPLYTAGRWRRTGKDRVQVGEVNGPVGIGKVRVESRDIVVADSNGVVIIPRNRVREVAGLARKISESEAQIRELLTKRGATLADTRRQLGYHTLQRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJS8</accession>
    <name>A0A8G1VJS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_453435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510970.1">
        <property type="nucleotide sequence ID" value="XM_025661053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJS8"/>
    <dbReference type="GeneID" id="37164455"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="334" mass="37400" checksum="3511C8DA4034BD2E" modified="2022-01-19" version="1">MPAQMDALGAFTHLTENIPSWIDRLAELSAHTAAKHAEYAEAYRRHVTVRPRRRKNSSVCSIRTEDLRSSEPETETRPQSSAAETHTTVTTPNTSQNQANVNPRKRGAEDAPSMDARDRNPLVSTRNNLIIHYDGHTQHVLEEMVRHIGTARNNIRKGRMSQLPLPGYRSKMLGRSARMNSLAPSLSPFESGEDDVLSSIRKARNRGPPVPRAQDMPKESAFDMAEKQLELVHGVCETAAYQFLRSGDCSTELTNVEGKFKSLLDLATNEVRRLKAEQPEEPTVEDETEASAATTIEVDRQSLTKMDTIEVDDDAQSAESIDLTAFRANRLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK98</accession>
    <name>A0A8G1VK98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_489312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514446.1">
        <property type="nucleotide sequence ID" value="XM_025663594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK98"/>
    <dbReference type="GeneID" id="37166996"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH56524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="215" mass="24166" checksum="DA1A50802401E856" modified="2022-01-19" version="1">MPGEALFTTASPSSLTPRYPQAHHGDTITFWVTGLASDEWRNNRGTSEASEGFVDRDEIDLVIDLRDFKRSSTSSSAPWPTLYIDRVSVEISEGFVDWDDNDPLSPRNFIRDATLARRCRAGRATDDELSDRLSHELKLQSARCIDRGLSFCQPDTGCPISNFIPKWIELVNFGSRTITKGTTDSRYFAGTITGEHDSIIYVKAGVNTFERDYDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKK3</accession>
    <name>A0A8G1VKK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_439376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514791.1">
        <property type="nucleotide sequence ID" value="XM_025658710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKK3"/>
    <dbReference type="GeneID" id="37162112"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027973">
        <property type="entry name" value="FSAF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053030">
        <property type="entry name" value="Ribosomal_biogenesis_FAF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096:SF1">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15375">
        <property type="entry name" value="FSAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="294" mass="32720" checksum="8EA8457D0D143EF3" modified="2022-01-19" version="1">MVGKRKREAAVVSRTTKVDEEEEKTTPQTETTDASATDVFRKFFEAQFQPLEVPGGQVTRGDESDEEDSEDEDFEEGSESGSDWDGLSGEEDEAPVEVVEHRDIKSQDLLDKKARKAFMTSKPPSYSEEPKPAKKKAKKEKSDDDEDAMDADNLKNDLALQRLLKESHLLESANELAPTGKNRIKALDLRMQELGAKASLYKQKMPTAHRRGIKEKAEMKEDRRRREAKENGIILEKPAPKSNPASTKRRERGVGGASIGKFAGGALNLSKRDVAAIQGPRRTTKGKGRGRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKU9</accession>
    <name>A0A8G1VKU9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_522945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511990.1">
        <property type="nucleotide sequence ID" value="XM_025665305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKU9"/>
    <dbReference type="GeneID" id="37168707"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="118" mass="12958" checksum="A6A6B8E77505477A" modified="2022-01-19" version="1">MGGKWDPGPFGIMANLAGAVTGRQTSQMNESDRLRELLENLRFLQVRFDKLDGRQCRSAARKLRRTGSGHASDTKTLNPVGKGLRLATSPNQERRGKEGGKVENLENGESGIRHRDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKW8</accession>
    <name>A0A8G1VKW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_451022</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513699.1">
        <property type="nucleotide sequence ID" value="XM_025660503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKW8"/>
    <dbReference type="GeneID" id="37163905"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000031">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF0">
        <property type="entry name" value="DELTA(24)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH55777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="516" mass="58475" checksum="B6F46871E222B976" modified="2022-01-19" version="1">MDTHNERVHQVSQKVKAFYETKQPFSIYHGSTNSTRASNKTKHNTVDISHLNKVPAVNRETKTVIVEPNVPMDVLVGATLPHGLIPPVVMEFPGITAGGGYSGTSGESSSYEYGFFERTVNWVEIILGNGEVVRASADENEDLFYGAGSCFGTLGITTLLEIRLIEVPPSPVVELTYFPFSNGVQQGVKLIQDLSSNSSYKYIDGIVFSKTAGVICAGKISSAEKTPYQLRTFSRPTDPWFYMRVEAAARASNWGQESPITDAVPLVDYFFRYDRGGFWVGKYAFEYLLLPQTKFMRWVMDGITHTRTLYHATHKSGLFREYTIQDVAVPYAGARDLMEFVDSSFGQYPIWLCPVRQTFPNTPAQVEQQQVKMLSERDNIQEKLLNFGIWGPGPKGKGPFLTFNRSLESLVHKLGGKKWLYARTYYTEEEFWKIYDKEKLDSLREKYHATNLPDIYQKVKPMVEDSVGGSGSESASLGKGRKSWGEWLAERVWHQWPLGGLYGLYHLLWNRDYLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL30</accession>
    <name>A0A8G1VL30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">High-affinity methionine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_422148</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515093.1">
        <property type="nucleotide sequence ID" value="XM_025657958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL30"/>
    <dbReference type="GeneID" id="37161360"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000025">
        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF498">
        <property type="entry name" value="HIGH-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH57171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="554" mass="60701" checksum="1A7688DEDB6B948C" modified="2022-01-19" version="1">MRDPVVESAYQKGILPDAKAVEEGPRRTDGVSGLYEGNVFEATPDDRRQIGVISASFLIFNRVIGTGIFATPSTILSLSGSVGLSLIMWVIGTLIAMAGTAVYLEWGTAIPKNGGEKNYLEYVFKKPKFLMTAMYAAYAVLLGWAASNSVVFGEYILNAADVEVDRWNQRGIGLACITAAFLIHSFAVKWGLMLQNFLGVVKLVIILFVIVAGWVALAGHMKIDPPHNFTNAFEGTTDTGYGIVMALYNVIWSFIGYSNANYALSETKNPTRTLKIAAPIAIISVGIMYMLCNIAYFAAVPKEQMLSSGQTVAATFFGNMFGARAEKVMSVFVALSAFGNVLSVIFSQGRIVQALGREGVLPLSKIWASNRPFNSPAAGLFEHWVVSVIIMLAPPPGDAYNFLVNLISYPLSIVNVFVSGGLVYIYLTKEKNFPDWAPGIRATLPVTIFFCLSNMYLVVAPYVPPSAGQSVYNNLPYYLHCVVALGIFALGAIYYLVWAVLMPRFGRYILVKESVVDADGWSRSVFTKMPLEQAEALRYQEAGEQQQEQQQHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL40</accession>
    <name>A0A8G1VL40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C6 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_500124</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512245.1">
        <property type="nucleotide sequence ID" value="XM_025664094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL40"/>
    <dbReference type="GeneID" id="37167496"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH54323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="454" mass="51448" checksum="DEB60A8F2DD4B0C6" modified="2022-01-19" version="1">MPGSRSSGCLLCVQRHVKCDETLPGCARCEIYGRECPGYDRGFKFVAGKPFRTPRRLKKPSAASQGVALQTRYPSPGPAPSRDLNMAQSLQNIVYDLAWPYTTASAYAVARWLRFLPEFYGRNRTLDAAVNCFVAHHIGHMTQNVQAVRYSRSTYVKALTALQRALDDHVQSVCPEVLCAVILLCMYELFANSTDSTSWMKHAKGLGQLVRFRGPSRYRGEFENNLLKASRGLIVMHSVFSGEECFLAGHEWHAVMQQDSDNIISHQIQVEIEDLFASFTSIPDLIHRMFKIRTANHTDPDTQLEISKLISETLAMRDKLEMWYERFTQLVPPPSEVPSSANDVLYPIVFYYASADTAPIFCAYYAYMTIVHQVLRTTSFGIPSTQAMYMVFYRDQICKSVEYTACGLLGPLRMAFPLRVAYEVGDSPTKAWIEGWLQRLSQHYGALSLRTFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMP7</accession>
    <name>A0A8G1VMP7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_513235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515664.1">
        <property type="nucleotide sequence ID" value="XM_025664699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMP7"/>
    <dbReference type="GeneID" id="37168101"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32247" checksum="4F8F3677A6537B46" modified="2022-01-19" version="1">MSDPTLYLYTSLTAGSSHIVTATARLETILKANKLPFRAIDVATDEVARKLWGRRSKGKKLPGLVKFGTVVGDLEQVEEWNEYGELRMQVNSVEDIDSIPATSTPIAPPSAASTPTPEPTTLKQSTIKIQSPPSKETPKDTAITAAMRQASGEAAAKAKGSGTQPAPAKEPAPAKEPALAVTEQKETPKETPAAGEQSQAGKEDTVRGNEAAPDTQASKPKRPPLVPEVAAESSANFHADAAEALGMVQHHRGSIISATSKEEQEKVAQDLRKSISGGQQDLLKSLREDNAARTDQEQTIEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMS6</accession>
    <name>A0A8G1VMS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_284586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515754.1">
        <property type="nucleotide sequence ID" value="XM_025655230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMS6"/>
    <dbReference type="GeneID" id="37158632"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="125" mass="13762" checksum="71ADAF26E52D8C9C" modified="2022-01-19" version="1">MTAPSRAILLWQIPGSGFSGWSLFARQVVEARASGGAAPLEAALERGRGRRYHVNYTMHASGNWPSTSDHVELSHAGDSRRCCQCQIQGRPRIAAVAAEDQLVTQRRGTVSLPVTSDYSKRRRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNP5</accession>
    <name>A0A8G1VNP5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="15">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_511512</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acetylxylan esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Degrades acetylated xylans by cleaving acetyl side groups from the hetero-xylan backbone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Deacetylation of xylans and xylo-oligosaccharides.</text>
            <dbReference type="EC" id="3.1.1.72"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the carbohydrate esterase 1 (CE1) family. AxeA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="15"/>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516937.1">
        <property type="nucleotide sequence ID" value="XM_025664600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNP5"/>
    <dbReference type="GeneID" id="37168002"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046555">
        <property type="term" value="F:acetylxylan esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF3">
        <property type="entry name" value="FERULOYL ESTERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034506264" description="Carboxylic ester hydrolase" evidence="15">
        <location>
            <begin position="25"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH59015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="304" mass="32729" checksum="FA67AADC55817C3A" modified="2022-01-19" version="1">MLLSTHLLFVITTLVTSLLHPIAAHAVKRSGSLQQVTDFGDNPTNVGMYIYVPNNLASNPGIVVAIHYCTGTGPGYYSDSPYATLSEQYGFIVIYPSSPYSGGCWDVSSQATLTHNGGGNSNSIANMVTWTISKYGADSSKVFVTGSSSGAMMTNVMAATYPELFAAATVYSGVSAGCFYSNTNQVDGWNSTCAQGDVITTPEHWASIAEAMYSGYSGSRPRMQIYHGSIDTTLYPQNYYETCKQWAGVFGYDYSAPEKTEANTPQTNYETTIWGDSLQGIFATGVGHTVPIHGDKDMEWFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP05</accession>
    <name>A0A8G1VP05_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial protein Fmp25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_222892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518213.1">
        <property type="nucleotide sequence ID" value="XM_025654722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP05"/>
    <dbReference type="GeneID" id="37158124"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000027">
        <property type="entry name" value="Protein FMP25, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053245">
        <property type="entry name" value="MitoProcess-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563:SF1">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="205"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="270"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="334"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="576" mass="63041" checksum="3A8213CCB8E6C402" modified="2022-01-19" version="1">MWTHRGRQSVTTVVTNSSRRLVRNNRSIATPWRRSYASSNKGPEPSVNSNWLRNSLGVAGAGTAAVFIYEYATSNPSQIEKPVEKVKDLAKSAEELSSQYVQHKRSVKSPGVYVWGNNAYRVVDPESKESVVKTPRKFAYFEGQVLRDLKLGERSGAAITENGDLVQWGKGYSETEFKPTKTLTGKNLASLCMSNDRILALSSDGNVYSLPIAKEDQLGGRKTKEGSWVPFRSGTSSISYRLLQPTLKLGERVTALASGLDHALLLTSSGRVFSVAASTENYPSFGQLGIPGLTWATRPKGPVDALHEITALKGSKIVQIAAGDYHSLALDKDGNVFAFGDNSFGQLAMEFNPSSPFCDTPTLVPIRNLYRGPWLPKATRVAAGGANSFFTVDAQRILSSKEDPATLRDLGRITADTWACGRGIWGALGTGKWTHVQDSLAKVKALSGLSEFDEKTNRLTPIRIHDLSVGTTHVSAVMNNSTHVDSAPSSTLNDTRDWGYDALWWGGNEHFQLGTGKRSNLSKPNYIHAPPEEADEQQEARLQIMPRHKGKVDRRTVSMEQRVVCGRHVSAIYSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP10</accession>
    <name>A0A8G1VP10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_446848</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518228.1">
        <property type="nucleotide sequence ID" value="XM_025659597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP10"/>
    <dbReference type="GeneID" id="37162999"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000095">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF365">
        <property type="entry name" value="ENDOCHITINASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="54"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH60306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="447" mass="48976" checksum="58AAAF52FBD2ADAF" modified="2022-01-19" version="1">MAFSRLIHCLVLFIVVLILSARYFWNDAAVLPLQPNSAPTTDTNATIPAMSSGLKSVAYFVNWAIYGRNYNPQDIPADKLTHVLYAFANVRPDTGEVYLSDTWSDIEKHYPTDSWNDVGTNVYGCVKQLFLLKQQNRKLKVLLSIGGWTYSPNFAQAASTDAGRTKFAETATKLVTDLGFDGIDIDWEYPKDDTEAQNMVLLLQKCRETLDATAGANRKFLLTIACPAGPANYTKLKLSQMTPYLDFYNLMAYDYAGSWDTVAGHQANLYPSADKPASTPFSTNEAVNYYIQKGGVPSSKIILGMPLYGRAFTNTDGPGTAFSGVGQGSWEQGVWDYKALPRTGATEHVDASLGASWSYDPTARTMVSYDTVAVGEMKLDYITKLQLGGGMWWETSGDKGGKTANKADGSLIGTFVEGIGGVSALDQSQNVLSYPESKYDNLRNAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP15</accession>
    <name>A0A8G1VP15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="2 9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_457174</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2 9"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518243.1">
        <property type="nucleotide sequence ID" value="XM_025661495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP15"/>
    <dbReference type="GeneID" id="37164897"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000049">
        <property type="entry name" value="RNA Polymerase II CTD phosphatase Fcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000142">
        <property type="entry name" value="Similar to FCP1-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="12">
        <location>
            <begin position="155"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="509"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="603"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="664"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="751"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="788"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH60321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="825" mass="91503" checksum="10CF885541035EC4" modified="2022-01-19" version="1">MLLRLPPSLHYPITVTSLLKQPGDKVERDEALFWYVYQTTVTEGDGLGNKVDVKRKFPTKFESTVDGEVVQWKIEKGDVIDEPVDVLEVDEPCAHEVQFGGLCAICGKDMTDFSYNTEVTDVHRAPIQMAHDNTTLTVSEQEATRVEEDAKRRLLANRKLSLVVDLDQTIIHATVDPTVGEWMQDKENPNYQALSDVRAFQLVDDGPGMRGCWYYVKLRPGLESFLQNVSEMYELHIYTMGTRSYAQHIASIIDPDRKLFGDRILSRDESGSLVAKNLHRLFPVDTKMVVIIDDRGDVWRWNPNLIKVSPYDFFVGIGDINSSFLPKKQELGPPSKGGEKPVAKAAKGGLAEHHVNGATAKRDDQTEVSTLEQLVTMGGGDNPRLLQEQSDAQEETIMHQVEDRPLLQKQKELDAEDDAAESSDTSSSIDDSQDLSKHRHHLLEDNDRELFDLEVRLEQVHRDFFDEYDRRRSRALGGRVAALRGEKPSKEKDVDLKLVPDVKIIMPQMKHRILGGVTLVFSGVLPLGTDTQNADISLWAKSFGAVIASKINMKTTHLVAGRNRTAKVREATRYPKVKIVTTQWLLDCLTQWKRLAEEPYLLPVHPDDRGEPISPGSKEVAESAWLSSSDEATGDSVADDEEATEEILKSAGISEMSPLGYDDEEQAAVHDELKEFLGSDDESESDSEATFMDETGTPSASKKRKREEGDGGGDDDDDQDTDSAGEGDEPGSRLAQRIKRSYERSTGLKEVASAGAVDSTASTTASATEPGTEEPEQVADESSPPDPAEVDPADEDDELEREMMAALEGGDYNSEAEEQIANENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP84</accession>
    <name>A0A8G1VP84_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-related protein RO7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_447074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518438.1">
        <property type="nucleotide sequence ID" value="XM_025659640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP84"/>
    <dbReference type="GeneID" id="37163042"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="571" mass="62963" checksum="073044040D21990C" modified="2022-01-19" version="1">MTSTSSTSAFDDRRPISMSFRHSQSGRPDSPHTPQHHLRSNNSSFASTSSASTSFRGEEDAIIFEFGARWLRAGFEGESTPMCVVGCGPEESRRVGDYRGWLRSNETDSSRSQPVKADKWAGAYELWKMDVRDMDMALIDDKIERMFRETYNKYLLTDAGTSRLVLVLPSIMPHPLLSSLLSTLFSRWRFPSITLLTSAPMAVVAAGLRSGLVVDIGWAETIVSGIYEYREMAVKRSTRAMKSLLQETGRFLTRLSDDSGAAQSADEISVHYELCEEIASRFLWCKPKAASQGSTATPQQQPAEAREEDSGAADQHTTSHSDATVSLPSPSGSGSTYIDLPFSKLAEPVEKVLFAEGLADCELDDEEKPLPLLVYHALLSLPPDVRGTCMSRIIFIGGGSNIPGVRQRILQDVAFLVEKYGWSPVRGKVIEQQRQKLESLRLSQPTKPTVTKQEGENETPDAAAARSTPDAQAEEEIDPIEQKIRRNNKDKDTHPPVQGVLREVESLGPWAGASLLTSLKIRGLVEIEREKYLQHGLAGASRDLEHGHAPDRRSGLRTGGDRSSWTLAGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ02</accession>
    <name>A0A8G1VQ02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_222022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518169.1">
        <property type="nucleotide sequence ID" value="XM_025654712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ02"/>
    <dbReference type="GeneID" id="37158114"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH60247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="86" mass="9656" checksum="4165695C986EE34C" modified="2022-01-19" version="1">MERVDPALLCLGEMEKHRGSPADRIFAYLSLSSSPINVEGDIGGRQMIDCLGLEINRIPEEMVAAYRFPTQQTRIGFLSRSRLALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ27</accession>
    <name>A0A8G1VQ27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_418938</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat TRM82 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516250.1">
        <property type="nucleotide sequence ID" value="XM_025657837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ27"/>
    <dbReference type="GeneID" id="37161239"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106004">
        <property type="term" value="P:tRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03056">
        <property type="entry name" value="TRM82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="441"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="481" mass="52530" checksum="7627F2E5FA9087DC" modified="2022-01-19" version="1">MSAQFQHPLQCLRLVQRSPTNILIGSAGSKLYSYSAETGQRLAVWPADVASSETNPVDAESTPEQGPPEKKRKVSSSEPQSIDKPAWSNIPIVTGTSNGEHVVALTAEDKCVRVFQLQEDGSFVQLSERAMPKRPSAITLTDDDNTILCGDKFGDVYSLPLIPGDKIPVVTKALRSAKLSHPAATNLTVHTKGNLRALEQQLRLASEGKRDEKSSGPTFEHKVLLGHVSLLTDMAYVSLPVDENKKRSYILTADRDEHIRVSRGPPQAHVIENYCLGHTSFISKLCVPQWAPQYLISGGGDNYLLVWNWAEGRILQKVSLVDEASEATEVAVQGIWATTLGDLRIILVALHGSSRLQCFTLESDGTLKTQASIQLSGNVLDLTPVEKDNTILVSVDSIRQPDSTQEWRASPASPSTLVEAFHVKIGSDSLAWEPTAASVTDKINSTGTEEVPATTEEKQRKELNDSLYGLGHLRKRKGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQK3</accession>
    <name>A0A8G1VQK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_361937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520071.1">
        <property type="nucleotide sequence ID" value="XM_025655603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQK3"/>
    <dbReference type="GeneID" id="37159005"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043534">
        <property type="entry name" value="EBDG/EBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041351">
        <property type="entry name" value="Ig_GlcNase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43536">
        <property type="entry name" value="MANNOSYLGLYCOPROTEIN ENDO-BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43536:SF1">
        <property type="entry name" value="MANNOSYLGLYCOPROTEIN ENDO-BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18368">
        <property type="entry name" value="Ig_GlcNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034567389" evidence="4">
        <location>
            <begin position="20"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="7">
        <location>
            <begin position="100"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="5">
        <location>
            <begin position="237"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Exo-beta-D-glucosaminidase Ig-fold" evidence="6">
        <location>
            <begin position="784"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH62149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="896" mass="98843" checksum="EF6E0C0F7C3A3DFC" modified="2022-01-19" version="1">MNLLLLLSSLLLLTTTATATTLIPDPGNRITIPTWHIQPTTNTTPNTLNLNLTTPDSHSTILATLLHPQNQPNPIIPPYNETALFHSTTLSTIPTTPFQSPWLYTTTLTLPHSISSHSNTNTNTNIILSTHGISSRGDIFVNNAHIGSISGAYNGQEYDISPEIKEGENEVQVKVYPVDYTRDFGIGWADWNPPPPDKGMGVWRGVEVRGVYGVAVQEMSVVVVGDVAEIEGGSGGKDVKVRVRVGVRNWGEGSVKGWFMGRVYDNSTDDDNNSGVQFAEAVTLRGGEVTTLEAEVTIKNPKIWWPATWGKQDMYTVSANFTLNDGTLSDTAECSFGIRSVTATFTDHGDEKDVSFNVNGYPFHVRGAGYSPDIFLRFDIDRVRTLLQAVLDMGLNTIRLEGKLEQPQFYDLADRMGIMVLAGWECCDKWEAWEYNTDLSKNHPWTNTDYLTAQAMLTHTSLLLQPHPCILAFLLGSDYPPNPRAFTLYTTALNHSDWTAPIISSASARIHPSGMKMLGPYDWVPPNYWYGERLGAAYGFGSEQGAGVGTPELPSLRRFLSEEELDRLWKEKNAGMYHMSPAGSQFHTRGVYNAALWGRFGKPKSLEEYVFLAQVVDYEATRAEFEAFAVRQNRSGRAATGVVYWMLNSAWPSLHWQLVDYYLKRGGAYYGVKVGARGVHVAVDYESGEVYVVNHGVKRGQGWVVVVDVVGLDGKRLYHEEVKGVVMGPTMSKKVTSVVPWVGGWDGVVFLRLLLKDSGGGVLSRNVYTLPGQLDVLDWDESTWYTTPVSEYANFSALRGLPTVEMGVSGKMGGGGGGVSVTLENRDKVPAWFVRISMVDEAGGEVDVWWEDNCVSVLGGEKVVVSGRVDNSGKMRIGRMRVVVEGGNVRRRGCYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQT8</accession>
    <name>A0A8G1VQT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_446360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519127.1">
        <property type="nucleotide sequence ID" value="XM_025659485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQT8"/>
    <dbReference type="GeneID" id="37162887"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH61205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="51" mass="5771" checksum="F5B4FF6ABDE10A8D" modified="2022-01-19" version="1">MTRLYEAWHVSCYSISLAIAQYPKPNIRAGPSLPYAILTYPRIMLEDVLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRM3</accession>
    <name>A0A8G1VRM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_465882</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519982.1">
        <property type="nucleotide sequence ID" value="XM_025662094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRM3"/>
    <dbReference type="GeneID" id="37165496"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000118">
        <property type="entry name" value="Phosphatase 2C-like domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000062">
        <property type="entry name" value="rRNA processing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="654"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1059"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1146"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1162"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1193"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1243"/>
            <end position="1258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH62060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1258" mass="140301" checksum="281D6F71A0936D96" modified="2022-01-19" version="1">MGSSCKASKMVPSHRSASQLWAIARRKLFTRREPRSSEHDSPQHRFFNSVSSSSFSEHTDGFYKYSLEVLQQSDEEYRDTVESMGLRSSDSTGMSYTSARTAPAEFPFSPYAVGAVEWNTVTGYLKNLDDAQGYDVSSWRNSVLAVYVKVYTVAKVVFMCFIHYCVELDGFQGGLMVCIRDAEDAIASKKIAPLVECVEKLYHALYARLMMELVMVDLCSCFSIEVTRVSSHNNFMLPEPRHLYNIFLTCKQILDSPTVCNIFNKESVRNYQATLVHRAVTKVNSMPFALDDLIGYRRFTLGIIDNPDSSFRQKWAGSALIYHMPPPKVLIIHSERYMSFTPRNTYQFMIPQQPLPFIQRHNVDPAFTESARTSDHRQAALAMLEGKTVGVLRNQGTMQQLIEYAKRRKCDCTQDPDRLCPCAEWNMILLLTQVNANRGTLGIRDRCTVLSKAVFQELSSIREDVDVFSGGAQVTGDGAKLVRKVGRGSQVGKIFILALAKIQLPEKKKESVCICACLGFPPGTAISGKLLAGMVPKTLVVSSTGCLSFFSSITPPLASPVVIRRSPLWSAHSGAPSSIWVRRYRAVWPSYGITTPIPDPNPQFPISRSPFCFQTGYALCAKRPSRPFPPPFLSPPSSSFSDPLTTHYLSQDKRLSVRGDLVRGLNNGDDAVLVAENYLAVNDGVGAWATKPRGHAALWSRLLLHYWALELEREPNGQSELDPIGYLQRAYEETIRATTSPGEWLGTTTSVTAILHWKRDAATGSIRPLLYVTNIGDCKIFVIRPSEKRILFRTKEQWHWFDCPMQLGTNSVDTPQKDAVLSLIDVQEDDLVVAVSDGIVDNLWEHEILTIVLDSLEKWQQGRHEDKDSEWAPPAVMADEQMVFIARELLKSALEIAQDPFAESPYMEKAVDEGLAVQGDDQTVKMRAKRSKKYRKLMHQYELTFGFREPYQVLVDSNFLRAVHSFKMDLIPALERTLQGKPKPLLTKCSLAAIMASQPINPKTNNPYRPEHLPPPTTLPLRHCSHNADSTPIDEVECLLSLLSPSAESKKNKEHYILATADPHNAKDKSATDNSAAGRKRKRDAEDKAEAALRKSRLLRRQARSIPGVPIVYVKRSVMVLEPMSDPSDAIREGVEKGKFRVGLNDEAKKKTTTAGDEEKTKKKRDLKKPKGPNPLSVKKPKKRAPEGTTAGKTEKPKREAEERPAAEDREGEEGDAAPKAKRRRRHHKGGAGKIEGDGEGGAEAVAAAGAPADAMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSC5</accession>
    <name>A0A8G1VSC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_392656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518575.1">
        <property type="nucleotide sequence ID" value="XM_025656852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSC5"/>
    <dbReference type="GeneID" id="37160254"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH60653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="43278" checksum="9588901B5C954D56" modified="2022-01-19" version="1">MEPRFDSIAYARLAKSYLLGMNRALSVANGDGFRAQDPVTEILLLEGYQRPVAPKKMTLPVPKISKSKEGFNYEANIFLGFTIPLEVAHEILRFLDLRSIGMMLLVNSKTKEQVETMLDYPILKTHAHETLNLMRQMRFSSHYTIGQIFNEFCQPKCRTCPNFGPFLYIPTMQRCCYECNLYKKSYGLGSVKKICYYFGIEEEDLNDIQLVHNIWLHDPQDCMANISQCKNLVSKLYGPEEAEILDVTVHIIEGEGVYLSEVEPTPYQRHGIPGGGCFWSERKRNRMKFMATVPFPYWDKRAQATDAGVYCTACAYFWREMVLSDGRGPWGCEEPCPLGWESSFRAYREADLPQHVETCLSVHAVEMNPELRPHDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VUE0</accession>
    <name>A0A8G1VUE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maleylacetoacetate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_7197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520675.1">
        <property type="nucleotide sequence ID" value="XM_025665614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VUE0"/>
    <dbReference type="GeneID" id="37169016"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="100"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="231" mass="26145" checksum="0D875857F6BD28F4" modified="2022-01-19" version="1">MQNQDTFELYSFWCSSCCQRIIITAHLKGITLKYNYVDLSARGHHDAKYKDELNPSASVPTLVVHHPDGTKTIIRQSMTILEYFEERFPNQSPLLPPVSAWQDRIKVRDLVNIIAIDVQAPTNSRIAKRVRSVRDNVEDQVSFVRQAFTDGFQAYEALISASSKFSFGDEVSLADVVLVPAVDQALMYKMDLDFVPNLLRVYHSLKELEAFKAGDGKNQGDTPEQFRAASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QR18</accession>
    <name>A0A8G1QR18_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_472921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509990.1">
        <property type="nucleotide sequence ID" value="XM_025662587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QR18"/>
    <dbReference type="GeneID" id="37165989"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF6">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="275" mass="32418" checksum="167D835437D23CAD" modified="2022-01-19" version="1">MKALNDDSFSRPEYPVIDELVQNAAVSPAEAVQNLLRVREVLHQERQESESPSDIDGNHTWYAMTKVVDTANITPADEQDKLIDFIFELHRTKVIDPATGEEPTAVDLKLWTEVPYLSIYLTDFYYFNFTPEYARQVDEDPQKEYPPSDLQEWENRNSFMAHLTRRAEYLCHYLDASLYAFYSCRSAFEEGPLIEEAVRTACIWYIYAGQRVWENCQAGRLFGDEDQTPRRDMHMDRWRLWKDGLRAAQREFPRESTQEMIRKALEEIKKAEHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QR31</accession>
    <name>A0A8G1QR31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_524496</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510180.1">
        <property type="nucleotide sequence ID" value="XM_025665418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QR31"/>
    <dbReference type="GeneID" id="37168820"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034024285" evidence="9">
        <location>
            <begin position="21"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="184"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="461"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH52258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="536" mass="59698" checksum="F60508BB667B7A6F" modified="2022-01-19" version="1">MRGWLRTLGLTALLAGSVLANEVELTQDEAHRQRCSGMYSRKAWGGSVDPFILTKFVQEPQSGDSDPLVSLVIFEWSDENLIGRPVPGDSGERETICDEASVQANLCSEDQVGSFILASNVTEASKFPVVTKAVHLNDPAAINYPIKKTGFYCVSTYGYSGVDYKAVIEFRNSYGELPAAQIAKLPFYGGLTIVYAVVGLFWAFLYVQNRHDILPVQNYITAILVFLIVEQLMTWGFYDYQNRNGLNTGAKALMVIVAVLNAGRNAFSFFLLLIVCMGYGVVKPSLGRTMIYVRILAITHFIFAVIYAVASLSITPDSAGPLVLLIVLPLAGTLTAFYVWTLNSLNATMKDLIDRKQKTKAMMYKKLWWCILGSIVVIFGFFFINSVAFAGRSEASFVPEHWKSRWFVLDGWLNLVYFFDIGFVAYLWRPTANNRRFAMSDEIAQDDDGFEIRSFGSALDEEDAFGGPEEPSGSEHRRDLSPVPPKPVPAAPRQRESLDGETIFAVGEDGDKWSDDEDESPRNSGERERLTGKHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRY0</accession>
    <name>A0A8G1QRY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_506067</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510660.1">
        <property type="nucleotide sequence ID" value="XM_025664367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRY0"/>
    <dbReference type="GeneID" id="37167769"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF3">
        <property type="entry name" value="HEXOSE TRANSPORTER PROTEIN (AFU_ORTHOLOGUE AFUA_8G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="35"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH52738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="517" mass="57160" checksum="7388AEF8373E5129" modified="2022-01-19" version="1">MRRESSIIGGSLAAALPVTDKYWFQQPHLLRLNLVLLVPLLSSSTFGYDGSLMNGLQSLEQWQDYFENPTGCLLGTIVAAQSIGSVVALPFLGNLCDWYGRKVILFAGLIIICIAAAIQCASVNLAMFIVARILIGVGGMFSSQPSPMLIAELAYPTHRGKYTSAYWTMYYLGAILSSWCTFGTQALSSSWAWRVPSILQAGYPVVQLAFLYWVPESPRWLVAQNKIDEATKILKRYHAGQEDPEEEPSPLVAMEIAEITTAIELEKSFESTGWSALTATPGNRKRTTIAICVGTFAQWNGIAVVSYFLTLVLNSVGITSSYTQTLINGFLQLFNFAAAFMAAFLVDRLGRRTLFLWSGIGMFISFIVWTICSALNSETGSKPAGYVVIVCVFVVYFHYDIAWTPLLLGYPTEIFPYSLRSKGLAVEMMSVYGSLIIASFCNPIGMENLGWKYYIVFCVFLMGILATVYFYFPETKGHTLEEIAVIFDGERSGLRHGDDDCIADGKMKMSSTHVEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS26</accession>
    <name>A0A8G1QS26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_507190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510515.1">
        <property type="nucleotide sequence ID" value="XM_025664390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QS26"/>
    <dbReference type="GeneID" id="37167792"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="129" mass="14717" checksum="83BC6ED13405605E" modified="2022-01-19" version="1" fragment="single">EDKYGRVKQWSREPASFCFCLRKFSCICSSYLPGSSFFSSHLNSFPLLTHAFCDPSHLLLPICIVFNLFTLADEPLGWGSGRPESAITFPFLLHFHFHTVGVCRHSSLVVGTLDQGSHIFSWYRLEQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSN8</accession>
    <name>A0A8G1QSN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_454314</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510029.1">
        <property type="nucleotide sequence ID" value="XM_025661257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSN8"/>
    <dbReference type="GeneID" id="37164659"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="56" mass="6138" checksum="B7DC59779FE1A55B" modified="2022-01-19" version="1">MPGKVGCCEIIIAFFLPFVGVFMRTGCSCDLLINICLCILGWVPGVIHAYYILANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT58</accession>
    <name>A0A8G1QT58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_453500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511039.1">
        <property type="nucleotide sequence ID" value="XM_025661068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT58"/>
    <dbReference type="GeneID" id="37164470"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH53117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="277" mass="29459" checksum="94F64E9FDC31D537" modified="2022-01-19" version="1">MVGRLAGKNALVTGAAGGIGLETTILMLREGASVLMTDISGPGLEKALNKVNEVVPERSGKVETRVVDVSKEADVEAAVGHLDAWGGLDVIFNNAGIMHAKDGDSEETPEAIWDLTMNINVKGVWYGCKHAVKSLRKHGKKKGSIINTASMVALVGAATPQLAYTASKGAVLAMTRELAIVHAREGFRFNSLCPAPLNTPLLQDWLGDDKEKRFRREVHFPTGRFGEAIEQAHAVIFLASDESSFVNAADFVVDGGLTKAYVTPEGPATEAPKNLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT86</accession>
    <name>A0A8G1QT86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GPI anchored transmidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_454097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825085">
        <property type="protein sequence ID" value="RAH52392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510314.1">
        <property type="nucleotide sequence ID" value="XM_025661201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT86"/>
    <dbReference type="GeneID" id="37164603"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000003">
        <property type="entry name" value="GPI-anchor transamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034074309" evidence="6">
        <location>
            <begin position="26"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="402" mass="45094" checksum="56F6E7F6D8340224" modified="2022-01-19" version="1">MLTPYSGLLRVLPLLLLALTATVSSEHTSNWAVLVSTSRFWFNYRHLANVLSLYRTVKRLGIPDSQIILMLPDDMACNPRNAFPGTVYSNADRAVDLYGDNIEVDYRGYEVTVENFIRLLTDRLDEDVPRSKRLGSDAGSNVLVYMTGHGGDQFLKFQDSEEIGAWDLADAFGQMWEKKRYHELLFMIDTCQANTMYTHFYSPNIIATGSSELDQSSYSHHADNDVGVAVIDRWTYYVLEFLETQVTSANSKLTLGDLFDSYDESKIHSQPGVRWDLFPGGEQEGRLRTVADFFGNVQNVEVENVNATEPGSLQEDLIEIARLVNKWRARDQAYLARQNESLVSKDASAHEESFPHYTVRTKVGPAKMSEESTWQKRLVGVSVLGACAAVWLTGSILGGTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTA7</accession>
    <name>A0A8G1QTA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_507240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="37167795"/>
    <dbReference type="Proteomes" id="UP000249526">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="926"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
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            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
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        <location>
            <begin position="279"/>
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        </location>
    </feature>
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            <begin position="555"/>
            <end position="590"/>
        </location>
    </feature>
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            <begin position="691"/>
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        </location>
    </feature>
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        <location>
            <begin position="850"/>
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        </location>
    </feature>
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            <begin position="881"/>
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        </location>
    </feature>
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        <location>
            <begin position="908"/>
            <end position="926"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="926" mass="100131" checksum="E2054C6C911E2FA4" modified="2022-01-19" version="1">MSVNEGNAWALRRAKEREQMRLSGDTEQGSLSSMKSVKTISPELGKLDFDSDLALPMPNPRTARANSIVNDTPPSLPTSGSGSGSLWSRSIAKKRSFTEPGRLAAAAASTSATGEKKSEKKSTFKALKAKLSFKDLKKEFRKEVPPASTMPKITILRDDSSSLDSFAAKGNTFEVERLYTPRPRVMESSVIRLDDCLKDFEKASDSSVRTPMKDGGGGAGGEGARFKHSLIHSNEAEEGHTSTLLDAVLLSGSSPAARTGELRNSRLPEVVSTPQRACSYAAEPASPKSAASTVRESEAARTYSPSVYETILSDRTSDLPRRDHGVTSIEEVISLTPTRDSDSSVKKGSDTRLSALASPVSTFQAGPDGSSSEYVTAQVPVDRAQLLGSTGRGGFAPTPPDPGYQNTAALEEQLASHVEQLHFHVQHAASKLVKTFEDKNAWHMDQVLRHVDTMVDIAQAINKKAAAQTELLKEAQTAVADVRAHIDTLRREVRVIKSKIITAIHEEIGKLRYDLQEEGKLGPGNPASEGILTPSAGLQGPSIPLMVNRDLSAQDDGRDKLLPRKEEGKYGEMKKKKTKNEQEENKERKQAAPSSVLRSANLVNSSSSAYLSVRDHQHQITEKRVAWKDNYEDTSGSPTPKASTFLDLPDLLVPAIEQAEALLTSAAQPKMDKPAPKRSFFNLLLHRDSDNNASRTQENKPQTVDNNKAQGKLTTPNPSHDPNLDPSTIHPVLRTPEQSKIIAERDLERIRLEKHQLAMLTTPSPTPARRPGVLKLSKSHSSIGGGAGTSTPESTSSSPPPTLHGWPLPDVYKNRLPAVPSRGLNSTPQQQQQQQQGFDNPYPIFRHPVPASTASGSIGSTSSSPAGFSPSQGGSGSRTDGPPPRPRRPPPLPLELISSNTTTVSFGRKREGSGRHRSGTLERVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTC3</accession>
    <name>A0A8G1QTC3_9EURO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BO85DRAFT_453123</name>
    </gene>
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        <name type="scientific">Aspergillus piperis CBS 112811</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511226.1">
        <property type="nucleotide sequence ID" value="XM_025660988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTC3"/>
    <dbReference type="GeneID" id="37164390"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="146" mass="16995" checksum="22A9007AD494E155" modified="2022-01-19" version="1">MEDAFSRFPGFQPNPSLSATEEFSRLAYHMNWTTGSKKYRKERVKFASTEFERYYHIGNKLQNYRALCQELRVEGPLTSVTQCRKALAKVHVNIFDLIDSRRTGAAVQRFPNQAALRKYTKDTEKIFPKQAAKADGFLKELLRRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTH7</accession>
    <name>A0A8G1QTH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_463259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511219.1">
        <property type="nucleotide sequence ID" value="XM_025661911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTH7"/>
    <dbReference type="GeneID" id="37165313"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="110" mass="12437" checksum="A418202079C6E680" modified="2022-01-19" version="1">MCRNAGNLDEPFNKHRSSVRYSRNRKQKAKLHEKVRDEKAEVERYTNAAETRGATTCKGRAGTGKTYRGGSYSSSRWGMVEGRKSQQVAVEREEGERDRGSNNKNNNPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTK0</accession>
    <name>A0A8G1QTK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exosome complex endonuclease 1/ribosomal RNA processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_453898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510494.1">
        <property type="nucleotide sequence ID" value="XM_025661155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTK0"/>
    <dbReference type="GeneID" id="37164557"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11370">
        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000024">
        <property type="entry name" value="Similar to exosome complex exonuclease RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="2">
        <location>
            <begin position="23"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="269" mass="28203" checksum="3283D0B9981442CB" modified="2022-01-19" version="1">MPLDTSTTYPLTKLRLDGRRWNELRLLQAQISTNPASSGSSYLAMGNTAILCSVHGPAEGRRGDATGGAAGSAGAVVEVDVNVAGFAGVDRKRRAGGSDKQSSRVATILRSAFQSHLHTHLYPHSTISIHVSVLSSDGSLLAAAVNACTLALVDAGIPMPGLLCGCTSGMSGSASTPRDPNNDTLDPLLDLSLPEEQELPFLTVGTTTAVPVGEAAMINEDEDEMKVAMLTMDSKVHCTYVETMLAVGIDGCKQIREILEGVIKKSARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTR8</accession>
    <name>A0A8G1QTR8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PEBP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_505891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510599.1">
        <property type="nucleotide sequence ID" value="XM_025664354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTR8"/>
    <dbReference type="GeneID" id="37167756"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF78">
        <property type="entry name" value="PROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="249" mass="27957" checksum="8E0B1EB655F218E5" modified="2022-01-19" version="1">MNLQIIVRCAIQGNEAREASTEAKVHIHAPSLNPEYRFFTSILFTTPPLFTPSSFKSQRSSVKLHQSSLSEMPTNFNVDRAMAVIRNEHRKLLTLTFSSHFIYPGQFVSKRDAAHPPRMSFPRLKGNGTYMIVCLDLDAPFPSCRVLGPKCHWIQSGLEPIMSENGHFFLRVAAPFIANYVGPNPLPGSSPHRYLFILYEQPAGFELTRSSPTGDKKMGAWSRLRFDLDGWAREIGLGPVVGANYFVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QU53</accession>
    <name>A0A8G1QU53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_524521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510212.1">
        <property type="nucleotide sequence ID" value="XM_025665419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QU53"/>
    <dbReference type="GeneID" id="37168821"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="555" mass="63194" checksum="25DE64A170A8AEB1" modified="2022-01-19" version="1">MVHIQDLPRELLLQIFSSVALSNLSNPQDQTTKSPDESAKTKSQQPPADRLFPRPPWVAEDEDDETDETDEEDPGNNGKGVSAQTQEIIDLYNLCRVCHLFRGLAQPLLFEHVDLSGFPGDLRNLVSITRAVLRRPSLGEHIRSLSVLPDHDHHVFHKSPQPLTAHDRKLFTSSIRDLRLDKEDERDWMTVLKEEEFDYSLMVVLLILKAPNLRMLTLAGGYFAMKPLEQAWKRHPAILSKLGDLWFEGDDLLKGYPLAIYEEMISRLQLRSIDIEEAHLSDDLFPACWTPQFLTMSRIGLHLCHIEMPPLSPMTSFTYDNFTTDPEDQPHNLRPVREPTAPELSAALLPHKDTLEGLTMTWNREPWERENIQDYVARQAKIGPLGDFSVLRRLTVQQAFLPPQPQFPPTLEKLIVEDCNISVRGLAEHLAQERRQGRLPALKSVKMLAVDITDPIKLPGQQIPFGQTPEQCCTSIKDMFKDTSVDFDILPYPDCPQNIAGDSDLDDYSDDDPYDMTDEYGLLGLREGGNSIFQAMLMQAMQAQGDQYMDDEFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QU92</accession>
    <name>A0A8G1QU92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_431086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510616.1">
        <property type="nucleotide sequence ID" value="XM_025658319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QU92"/>
    <dbReference type="GeneID" id="37161721"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000002">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398:SF1">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="578"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1049" mass="116704" checksum="2421169785AA513B" modified="2022-01-19" version="1">MNRILHQFVFLIDQLCQSDPDRPVGDLEAFSPNDLREIRALHPENIPTVETSFPAIFAEQVAWSPEALAVDSQHGVKLTYAELDRLSDGLARYLISLGLMPQDEVGWCSEKTPWTVVGIVAIAKAGGIFIFLDPSHPPSRRAEILQTGQPRLILAISPHDGLFQYPDAQPVDAVVLVDERLLTELRDQKHGALPDSLQADSGLYNQFTSGSTGTPKGCLVEHSNFLSSAAIYTHRTNLTQQSRVFQVSSYNFDSSILEMLASLTVGACVCVPREEARSDDDLPGTMNDLAVTWALITPSLARTLLATSVPSLQDLVLAGEALSEVDVKTWVASVRLYNGYGPAECAILTTVNRIVNTDVAPNELGKPLASANWIVCPQDPNKLAPLGAAGELLIEGSIVGRGYLNDSHRTKHRVYLNGDLVRYTRDGSISYVGRKDLQVKIRGQRVELGEIEHRLWTHSLVNNAVVVYPTSGRCSRQLVGFLALTRVTSFAQNPDDVTLLPNHVLPTITEDVRIIENSLSSQLPSYMIPTVWVPLSSIPLLVSGKSNRRILLNWLAGLDDPTFTTIVNLGQNESTETRPWSQTEETLRTIWGKVLNLPFERIHLNSSFLRLGGNSISAMQVAGLARKANIDFPLTAVLGSSSLKELATSARAIPKISRAKAPSLFKRHPMLRARFQHQQRGNERHSQMITNEVFTSYRLQTHQSSALEDTCSALEASRVSLDIYSGPLLAADLVETETDQVLFFTIHHLVTDMVSWNVILGDLEDFLLRGEFRYAEEESYPFQDWCKLQEQHAQMLDPASVLPFSVPPADFDYWQMEHETNLLQDLVGEEIALDKDQTAKLLDTNDRVDVQDFIIAALLRSFVMVFDDRCPPTVFRYDHGRRPEGQEIDLSRTVGWLTTVTPVTVPVKAHDSLSTIVHRTHAVRSSIPGSGWPYFISRYLTEDGAAAFQSHNRIEVLLNYLGSGLHGQATTPVKTRLERSQAFSDSTEGGLGARGQPVRRFALFGVQVQLLDSRLIIQFEYNRRMKHQDGILRWISALRGLLDEDILLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUF0</accession>
    <name>A0A8G1QUF0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">60S ribosomal protein L20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_404744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511781.1">
        <property type="nucleotide sequence ID" value="XM_025657283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUF0"/>
    <dbReference type="GeneID" id="37160685"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="201" mass="23146" checksum="16A26FFC51C5AD60" modified="2022-01-19" version="1">MANCLAAPRRPLLALPFLLPSPYECVTLGLRRNQSSYRRTKQRLRVKPDASFGSSVSHSQEDHIIYNPPSSAPSVYHTPTKFLPSDDIRRNLRNASVKGSNAESLPLAAKVTTEKKYHLNPSDIREIRRLRATDPMTWSRLKLAKRFDCSPMFIAMVCEASPEKKDIQKRILEAVQSRWGSKRRMAREDRQLRKETWGRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVC1</accession>
    <name>A0A8G1QVC1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_480869</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511578.1">
        <property type="nucleotide sequence ID" value="XM_025663030.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37166432"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF49">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="36"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="886"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="886"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1027"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="918"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH53656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2853" mass="312572" checksum="AD70C4D011F1F1A8" modified="2022-01-19" version="1">MDGLDVKSSPSAILSHCKDHHGAVQPEVYSNFEPVPFPIAIVGMSMRLPGGVNGERELWDLLINKRDGRCIVPQDRYNIEAFYDETRPGAIRTQHGYFLQQDISQVDAGFFAMSKLEAGKLDPQQRILLEVVWECLENGGQLPSQCRGKDIGCYVGVFGEDWLDLMSKDTQAIDRFRVVSAADFALSNRISYEYDLRGPSITFRTGCSAALVGLHDACQALYTGECSSALVAGTNLIITPTTTNAVSETMALSSDGISKTFDASADGYGRGEAVNAIYIKPLHACLRDGDPVRAVIRSTAVNCDGKTPSITTPGSQAQEALIRKAYQKAGVSDISKTAFFECHGTGTIVGDTAETTVIANVFGHEGIHIGAVKPNLGHSEGASGITSVIKSVLALEHRILPPNIHFNTPNPNIPFKEAKLQVPVDPTPWPAGRCERISVNSFGIGGTNAHVVLDSALSVGAVSQSGVASDERPGAPHLLLTSAKSAASLDGNIKIISDYLHDAPTAAADLAYTLAFKREHMQHRAFAIVEKDGTISTFEKARAINPQICFVFTGQGAQWPGMGREMILSSEKFRRFQEAKFAQPLCTAIQVALVDFLRELGVVPSIVVGHSSGEIAAAYASGAITAASAIKIAYFRGLAMELAKGNGAMAAVGLGRAETENYLKNGVVVACENSPESVTISGDEQAVDEMLKDIQAQGEVFCRRLAVNVAYHSHHMNEVGELFESLLSEICFNESMTPLVSTVTNETISDPCALSPSYWRKNVENPVMFSTALSKILCDDEKALAFVEIGPHSVLSGPLRQIIAGTNSKRSCSYTSTLIRNEDQWRCLMSTAGQLYAQGISLDLSSLVRPAATVTDLAPYSWDHNESFWSETRLTRDWRLRSAPHHELLGSRALESSDLEPVWRNMLQAENVPWLLEHKIGGEVVFPGAGYVAMVGEAMRQISQVPEYSVKNVFMRAALVLKEAKLQHVEIITSLRPVKLTDSLDSGWYDFTITAYNEGEWKKHCVGQVRAERDGFSHEDGTVSPYSREVPAKEWYDALEKRGLEYGPNFRGLRDITASPTTTEAAATLYEPTALTGSCYALHPVVIDQCLQLLSVAGAKGIQRSMTQLCIPTAIESLYVAPGQEVMSLKSTCDAAGNTFTGDALLLAGEKPVLSLRRCFFFGISESAINDENGASAATLHWKPHLDFLPLESLIPPIPADIDRGRMAVELTNLFILEAYHRTRSSRPTKEHLKKYHKWLLSQYERIKSEDPSLVFEMDKSGSNPEGYLSQIEEFGESIEHALVSSVYTAGYEMLSHIAGILDDSLDALEIISGSDAVSSMYQESSRLCPAENFLSLLSHSRPTLRVLEVGAGTGGATSAVLDALYDATKHEGPLYSSYTFTDISAGFFAKAKEHFRTFPGMIYETFDISKDPEDQGFAVEGYDLIIASNVVHATLRISTSLRNLNKLLAPGGWLFLTELCPGLPMINFIMGTLPGWWNAEDSRETPVVPVSRWHQELLDAGFTGVDIVRYDNEPPYETNAYILSRRPQARASLNKEIGFLHKGKIPSLAYTLAQAYTHQGVKVTWLTLNDLSSSITDVISFLDMDSPFLDSLSDDEFRAFQGFLSSVKGHCLWLMPPVQFGGGDSDPRFGLTLGYMRTVRKEISTNFATLELEQNESGAAEKIALVFERICRQSGKNPINEDYEFALKDGAVHVGRFRFQFLHQMMAADDSFEQRSLDIGCFGIFDSLTWALDGRVGQLGEHDIEVDIRFVGLNFRDIMISMGLMGETSEIGLEAAGIVRNVGSGVQNIQVGDKVSIFGKGLMGTRKIVPAETCLVLPEGLSLKDAAAGPCVFSTALYSLVKCGNLQKGQTVLIHSACGGVGLAAIQICQSIGAEIFATVGSLEKRKHLMGEFNLPEDHIFDSRSVSFHRDVMKATGNRGVDLVLNSLSGELLHASWKCVAPMGKMIELGKRDFLGHGKLDMDLFMGNRTFIGVDLLQIGEQNPEVIRSLVQQFAHSIEQGKLRPIRPVTVFKASDIAKAFRHMQTGKHMGKILVEMPEKPSDLQVSKLQAKGALFRSDASYLLVGGLGGLGRAVARWMVEKGARHLLFMSRSGLETTKAREFVLDMESQENCHIQVVTGDVTNINDVERVVSAAVRPIAGIMQLSMVLRDQTLDKLAYEEWTEALAPKVQGTWNIHHATRNCSLDFFALLSSVSGTAGHTGQANYAAANTFLNAFVTYRHSKGLQASVLDIGFMGDIGVVAETSHKIREMVEMSSWEVLEEPDLLKALEIQIMRGAPHLCIGMGTTKPVSQIENGSTFGQDARFLAWHNMLTASEGGRANQDNELKTLVNAVKRDPSLLYDPATETKITLEIGRMVASNMSYPDDMPYEELCEIAIDSLMTIEIRSWFRRNVGVEVSLAQISKAQNVKGLGAITMQVLREKHKSGELENAKGSLVGNGKDDVDESVLYRADLELAKSLEPISEHVPCWHSESEGRVFVTGCTGFLGAFFLSTLTSHPRVKEIACLVRAPDAAAGLARIKENLEHYGLSLDSESKVIVVPGDLTDSTLGLGQEKYEHFAQWTSVIFHLAAQCNYMPSYSELRGANIHGFSNILRFANTKRLKPVHYTSSISACGTSAYLEGRELIGENERPVLNTTGSERKLVGYSETKIVAESIAWDAIANGMPVTIHRLPVISGHSKTGIANPTDGFQHMMVSAIRVGCYPSPPAARCQMIPVDYASSAILEIALSNHHSHAYNLVIPDQSHTLTWDDVLDTVAHYTSPPLKRVSALEWADIVATHGEHHFKVASTFLQDKIRELLVYWEAETMTKTVYENANSRRVLLASSDMPELPSMLELLSKYFKVWQKEEQKQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVY8</accession>
    <name>A0A8G1QVY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic-amino-acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_95423</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512570.1">
        <property type="nucleotide sequence ID" value="XM_025665808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVY8"/>
    <dbReference type="GeneID" id="37169210"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="44"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH54648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="419" mass="46290" checksum="FB12AC780D7216B9" modified="2022-01-19" version="1">MTTQTSTITPTGTTPPSFFETAPYIPPDAIFALTAEYNADTFTQKVNLGQGTYRDENGQPWVLPSVRKSREMLVGQGLNHEYLPILGLQAFRQEASKMALGSGLYERIQSRLATCQGLSGTGSLHLAGLLLRSCRAPLPKIYIPSPTWSNHHQVFSSLGFTCESFGYYDDAQKNLDIDSYYSALKQAEPGSVVILHACAHNPTGCDPSKEQWKEVGRIIKEKRLFPLFDAAYLGFNSGNIDDDAFAIRYFVDDLDLEAGVCLSFAKNMGLYGERTGCLFFVAHTDKAATNTQSVLEMLQRSEVSNPPAYGAKIAATILSDQQLKALWYKDLETMSGRIRAMRRALYDSLNNNGAPGNWDHLIRQSGMFGFLGLAPDVVQELKVQYHIYMAGNSRVSIAGLNDKNVEYVGRSIAECLKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QW86</accession>
    <name>A0A8G1QW86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_441906</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511904.1">
        <property type="nucleotide sequence ID" value="XM_025658819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QW86"/>
    <dbReference type="GeneID" id="37162221"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000067">
        <property type="entry name" value="t-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000019">
        <property type="entry name" value="t-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF380">
        <property type="entry name" value="SYNTAXIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="206"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="308" mass="34565" checksum="220844925115280F" modified="2022-01-19" version="1">MSYGENQGGYGQYNPYGQQDANPYSDANAMEQGNGSYEMGSYNQPADATTLLNKCREINDGIADLRAKREGQLAAAQNALLDSSTGKEDQVARQTLDYIEDEVNNGFRYLRDLLKKVKETPGSGDSRVQTQIDVTSRNLRREIEQYQRCQSDFQKRLREQVRRRYEISNPEASPEEIEQGVNNVLLGQEQSFQVTGSRTRQANDARQAALERSAAIRKIEQDMMELGRLYQEVAELVHQQEPAVEQINQDADNVAQNVSNANNQITEAIASARRARKWKWYALLVVILIIAIVVGVAVGVTEANKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWV7</accession>
    <name>A0A8G1QWV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED10</name>
        <name evidence="8" type="ORF">BO85DRAFT_377619</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWV7"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH55052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="162" mass="17774" checksum="E44C08EF8C907366" modified="2022-01-19" version="1">MAPIPLSTVDTDLKDVIQHLFEIQSAVHGYLGPETQQELVRKIKNLTLALSTLSTHTSDNHPDAQSQSPGNSNDPPIHSIQLPPEIIDYVDAARNPDIYTREFVELIQRGNQDLKGKKEAFGSFRDVLAREMRGAMPEVRGEVDRVVASFGGDGNNNGDGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX20</accession>
    <name>A0A8G1QX20_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-PSP endoribonuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_453600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510867.1">
        <property type="nucleotide sequence ID" value="XM_025661087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX20"/>
    <dbReference type="GeneID" id="37164489"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="139" mass="14627" checksum="0D14E791ABDE7714" modified="2022-01-19" version="1">MSKATRIPIRTQKAPLPPPFLSQGIVVGDMVYCSGQVGVNPATGKMVEGSIQERTKQILNNLSAVLEAGGSSLQDAVKVNIFLADMNDFAAVNEVYSSFFADPKPARTCVAVKTLPMGTDVEIECAGVVSSVPGRGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXM1</accession>
    <name>A0A8G1QXM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_376188</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513690.1">
        <property type="nucleotide sequence ID" value="XM_025656213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXM1"/>
    <dbReference type="GeneID" id="37159615"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF17">
        <property type="entry name" value="SCFA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034102310" description="Xylanolytic transcriptional activator regulatory domain-containing protein" evidence="5">
        <location>
            <begin position="32"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="8"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="355"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH55768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="535" mass="59298" checksum="B40374054636ED3F" modified="2022-01-19" version="1">MLDSQSVSPRQRGTAVLILMVLALGARYASDEQISRIDISRNDVTSLQETMLSHIRSQFFDVLDTGGVECVQLCILLSTYHLYNGKPNLAMPILGAGIRSAQAQGLHKESLWGPATDIVLEIRKRTWWALYALERLYSIAGPIISDIYDLNASNLEAVMMQAAEINTKLVEWFDGLPVELRIERHARLDTSHLTSAETEVCQLFQLQALVLQLAYDNIQIVLHRPFVRYTRCLPLLPGWRNSDARPTSFEQCKHCARRTCSILPRYSKVLLAAQSTHAAAYIAIQNFTAGVTLGMVALSDPGSEQSLDAKRGVANSIALQKTLAASSVVSSQTVRVLEGLFRLIFKREMQSLLDNSPLHMNSPSPKNSLPTSTNDYHHETYQDTNQLNPHASDSFNQPFGSQENTQLLSRNQGALNVSQNTPEARTVIDPDVGQDVTTLPCYPEIDRALEAVQQVMWENCDTMAHASSRAMDTTSSSFADPGQQTLATDFIEPDNAFQPTTLTASVADPASHDLNTLHNSLIGQSWVWNQTDLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXT2</accession>
    <name>A0A8G1QXT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nitric-oxide synthase (NADPH)</fullName>
            <ecNumber evidence="3">1.14.13.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_463026</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOS family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.39" evidence="3"/>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511242.1">
        <property type="nucleotide sequence ID" value="XM_025661891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXT2"/>
    <dbReference type="GeneID" id="37165293"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.340.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1230.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.440.10">
        <property type="entry name" value="Nitric Oxide Synthase,Heme Domain,Chain A domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050607">
        <property type="entry name" value="NOS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044943">
        <property type="entry name" value="NOS_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044940">
        <property type="entry name" value="NOS_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044944">
        <property type="entry name" value="NOS_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004030">
        <property type="entry name" value="NOS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036119">
        <property type="entry name" value="NOS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410:SF1">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02898">
        <property type="entry name" value="NO_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56512">
        <property type="entry name" value="Nitric oxide (NO) synthase oxygenase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitric oxide synthase (NOS)" evidence="10">
        <location>
            <begin position="75"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH53320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="493" mass="55718" checksum="07F3E1000110DD3D" modified="2022-01-19" version="1">MILDLEPAVAYAGYTKISHDSGAAPSTRCPFEEYERILEKNPILAPTGCTEESCQAGRLIHSAEPKVGKNRPLEVVKNEAVAFLWQLWQEGIYTEDRYLERRAQVLEEIARSAKTTIVWDQGYKRRRRTCYGLRLAWKNSRRCIMRSRYQDLGLCDRRHIHTSVGMATALLEEATKAFNGGQIKPTVFVFPPKSVDGSGPMFWDKQVLNFAGYELEDGSIVGDPSNVKLTQDIIDLGWAPPRPKTPWDLLPIVAMAENDAPALVEVPDDLRRLRWYQFPALIRLGFDIGGLQYTATPFIEWYMDAEIGVRNLTDTFRFDALPEVVNAIGFVIDAYRAKPDRAQTMLNYAVRWSFLQHGVTCGSIIPVWHHGGAPNYQPNPMICRNRYDPVNSWQRRKGSTEAVPALLVRNGNTWVTEALTRFATDNSGPKRCKLTESPSKEQPCTVHISYCSQVASTTGSGAFHANKADFAKALGHFRHTLKIDFFRVCHHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXY9</accession>
    <name>A0A8G1QXY9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phospholipase D</fullName>
            <ecNumber evidence="1">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_442388</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.4" evidence="1"/>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511317.1">
        <property type="nucleotide sequence ID" value="XM_025658835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXY9"/>
    <dbReference type="GeneID" id="37162237"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000032">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000034">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF186">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="1002"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="428"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="43"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="485"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="549"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="636"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="647"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH53395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1236" mass="138150" checksum="DA3AFAAC5C7BFFE1" modified="2022-01-19" version="1">MTRPEDDLAYGQYYQDSARGASSGDSSRGLSDTFKKLKQTYKSHQSQQGSSQQTQQSQQSQSASYYNTSNQTYQSQGPSQSQPHPPPQQQQPHSSKPQKQDKFSGLFGKLEEFGNEVAQKLGTALDPQAYAEYGAPKPQTENRFGSFASPRQGNEVKWHVDGCAYFYAVSKALESAKEYIWILDWWLSPELYLRRPPAKHEQYRLDRMLLAAAQRGVRVNIIVYKEVTQALTLSSHHTKHHLEDLHENIAVFRHPDHLPDRQELEASIHTSLQNLSLDAGNLAKMSEDAIKGIYGMHEDVILYWAHHEKLCLIDGRIAFMGGLDMCFGRWDTNQHELADVHGQDLNKIVFPGQDYNNARVSDFHDVAHWEQNQLDRKDTSRMGWSDISVSLHGPVVEDLRKHFVQRWNFIYDSKYQSRNNSRYARLSLYGRPTSGPQQQGPQQGGQAQKPPASPQPGATGPPAPSWQQQAASPQPGANPGPPAPSWQQQAAPSQSAQPPSTSSSSTPSWQQQQTGVATTQPPSAANPATPTWQQQAPVPQGGYPASHSPDPSSQEKPSWQQQTAQPSSYNQPQAQNTGSQEKPSWQQQPAQPTGYSQPQTQSTGSQEKPSWQQQSSEPPAYSAHPQQHYTYSGDSFPPPPPGPPPAQGTAQTSYQAYNPQQQQQQQPQSHTPTQAQSQGQTQYYPPPPSQEIHHSQTRGIHDASGGYGDSERGFNPRRLRENFMDYSNVLRGELAGQIHQYQDRFSTHGRQASQPRGNMTCQIVRSCSKWSNGTPTEHSIQDAYAAVIRNSQHFIYIENQFFITATGDAQKPVENKIGVAIVERILRAARAGEKFKIIVVIPSVPCFAGDLSDESTLGTRAIMEFQYNCINRGGSSIMEMIAKEGFNPMDYIRFYNLRNYDRINVSGPLMQAEQQSGVNYEDARKQQDVATGGPGSYGPGAPRAAFDTTAPYQQYQQAAQQVGGKSGQWDSVSSCYMLNGPDIRNVPWNGPPEAEIDAFVTEELYVHSKVMVADDRVAIVGSANLNDRSQLGTHDSEIAIVIEDYTPVQSRMNGQPWTASRFAASLRRQLFRKHLGLLPPQDPERPDGNFEPVGVPNTTDFESPESQVVADPLADTLHSMWNTRARTNTEVFRKVFHSVPDDTVRNWATYKEFYGYYFHNADKQAYGEDESRPARYKYGHVVRDDFPPGPEGVRQVKELLSQVKGTLVEMPLMFLIEEDVAKEGLTLNEITEPIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXZ2</accession>
    <name>A0A8G1QXZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_470257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513885.1">
        <property type="nucleotide sequence ID" value="XM_025662385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXZ2"/>
    <dbReference type="GeneID" id="37165787"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="184"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH55963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="348" mass="38835" checksum="CF05425BEBC3B0E4" modified="2022-01-19" version="1">MPTQEYFDQIPPFPSELPVVSLSKISLEGLKNNTTEEVEELFEACQQWGFFLLDLRGSDEGAALLQDAEGMFELTTQLSTLGQETLKSYTYKPPDFMRYKGIGSIKTDNGEADHIHAYSLSQDEVLGYPNRSSLHPEVINTSKEQLRKFIEHAHAILDEVLAKLDICLGIEPKTLEALSPLDQESESLVRLLWSPAQANPDYDRISFGGHTDMGTMTLLFNIAGGLQVLPASRENVKENWQYIKPEPGCAVVNVGDTLVEWTGGVLRSSLHRVVTAPGDQAMVQRESVAYLVRPKRTASLQRLKGGVIPPLLPGEEDETRSVDEWNEWRSRQIALGQLKPETRGGRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY53</accession>
    <name>A0A8G1QY53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Chromatin remodeling complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_480232</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512671.1">
        <property type="nucleotide sequence ID" value="XM_025662996.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37166398"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056616">
        <property type="entry name" value="Chromo_MIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055565">
        <property type="entry name" value="DUF7141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040934">
        <property type="entry name" value="Znf-CCCH_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041684">
        <property type="entry name" value="Znf-PHD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23615">
        <property type="entry name" value="Chromo_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23614">
        <property type="entry name" value="DUF7141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18585">
        <property type="entry name" value="zf-CCCH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15446">
        <property type="entry name" value="zf-PHD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="656"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="964"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="133"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1399"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1443"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1414"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1456"/>
            <end position="1478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH54749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1498" mass="169960" checksum="C8C481FF0DCDC87F" modified="2022-01-19" version="1">MDLLLQTLGSGDGPDNADNDGDMVKELFAKFNNPTVSREEELEPQSISESSVTVEIPVTSTIDLSQYEFLPGHFDVRYVISETSEADAGLSYQVKLQSGETETMSFAQLQSLQNGPESLSNFLDYGPDHCISSRSASAVPSEEQSPSSESDIPDMRRSRRTTRGQRSGFTAFFEAISSDEGARRTRRKRSSSSEDIIASSGATSKKRRVLRRRKKHTRSVVSLSDESDYSAPKGTRHSTRTRKSKKKSLRERNEDDISDAEDAPRMQKFFGAKEFFRKVPEHDTFRQRHRNVCEVCHIIGDDYAKGPLVFCQGCTSAYHQGCLGPRSAREHLVTKVAEDLFLLQCRRCLGISHAKDPSNPHQGRCSICNIRGNMSKPIRERLTPKQEQQLRQQNDGKDPITPFDMSRVNDVENLLFRCTTCRRGFHFEHLSEITHMTWQCESCASVPGEVGAIVAWRPVVHKSDAAKGADREYLIKWKNKSYNHTTWMPGSWVWGFVNHHMRRAFMRSDKSLEPCMTAEEAIPEDFLLVDIVFDVRFSGTSPDTGRKRTFEEDVARVDDVVEMYVKFKGLPYEEVTWDTPPERSSNPERWESFRAAYEDWVKREYTHIPNQDNLRRRIAHVRKQNFSSNVVKSGQPETMTGGQIMDYQKDGLDWLYYMWYKQQNAILADEMGLGKTIQVIGLIATLVQYHKCWPFLIVVPNSTCPNWRKEIKTWVPSLRVVTYYGSAFSRKLAQDYEMFADDDTSLRCHVVVASYETLVDDASRRLLSKVPWTGLIVDEGQRLKNDKSQLYDALSRIKFPFKILLTGTPLQNNIRELFNLLQFCDPSKRADDLENEYGDLSKENILELHNMIRPFFLRRTKAQVLSFLPPVAQIIVPVSMTTVQKKLYKSILAKNPQLIKAIFQRKEGTRALKQTEKHNLNNILMQLRKCLCHPFVYSRAIEEKTSNAAISHRHLVDAAAKFQLLELMLPKLKNRGHRVLIFSQFLENLDIIEDFLEGVGLMYLRLDGRMSSLEKQKTIDAYNAEDSPYFAFLLSTRSGGVGINLATADTVIIMDPDFNPHQDMQALSRAHRIGQKNKVLVFQLMTRASAEEKIMQIGKKKMVLDHVLIDRMVSEEEDGRDLETILRHGAQALFDDDDSGDVRYDSESVDKLLDRSQAEQASTPDDNNQGNQFSFARVWANDNQNLEDQLQNVEEEPAPSADVWEKILREREQAAAEEARRKAETLGRGKRKRTAVDYANDALMELSPNKDRHAREEVESDREFTADDAMESESDFAPELDFDDMNQVAKTSKVRAFQRVTQQDLPPPLDGNVEPVLHPGPPCLACNRVHVVGHCRLKMAGVEHCPLCGLAHYGYSRTCPHLRSDTQVARMLAALKQSTEDRELVQLAKKYLNGVRGDLAQRKRKQASKAASSLTNPGIPTTDSNASAAVTTSSPMIDLTAQHTTQATHEAPSAVGATNSSIIDLTSNDGTRQSTYQQPAWAPPQSFRNPYGYSGHEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZI0</accession>
    <name>A0A8G1QZI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maintenance of telomere capping protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_426513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512942.1">
        <property type="nucleotide sequence ID" value="XM_025658117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZI0"/>
    <dbReference type="GeneID" id="37161519"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="54413" checksum="8858FDC29DA169DC" modified="2022-01-19" version="1">MRPKSSKPTSDELLAQFDDLGVDSAPEQQPSKAAPKPTTAQSEQDILAELDSLATQRPSSGPGTPRVSTNEPRPTIKSPKPAATATTPSTGRSSEEKQAPRKSEESTRASATEKKAADAPKPETEKPEAQEKPASSGGGGGWWGGIFATASAAMKQAEAAVKEIQQNEEAQKWAQQIQGNVGALKDLGGELRNMAIPTFTSFIHTLAPPISSHERLQIHVTHDLSGYPSIDPLVYAVFSRVMAQVEGGDLLVIQRGQESAPKRGLDIGGAQFSGPGWHDGPWWRTVTPGSPRTLSAIRGTVEATKLARASAEAYATEYFSAKGGVEAAAKQATQDLSETNPVRSSDIFLAIQAISQTTSTELFQAGPTTDQATPAGVVDVPEAAEEEVVFALYLHDPIHGVAFHTLSQAIPQKWIDWLETPAIPVEDPESEDASVPRTTIPDDIADIIESGGVDPREWAAEWIEESLSLAAGLVAQRYVARRMGVGEGGPAKGKMRAEQASVVDSGAGEAARAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZM5</accession>
    <name>A0A8G1QZM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_66348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513734.1">
        <property type="nucleotide sequence ID" value="XM_025665572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZM5"/>
    <dbReference type="GeneID" id="37168974"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="74" mass="8440" checksum="E9FCAF2847837CDB" modified="2022-01-19" version="1">MKVKNETRKRTTRGFCEVALSTIGLFYLLVYFWGGINYFLNTHTGCFVICSSRATVLLAFFLHVDVTAEQRGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZU0</accession>
    <name>A0A8G1QZU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_469361</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514580.1">
        <property type="nucleotide sequence ID" value="XM_025662328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZU0"/>
    <dbReference type="GeneID" id="37165730"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005536">
        <property type="entry name" value="PRK07198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="7">
        <location>
            <begin position="36"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="6">
        <location>
            <begin position="268"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="785" mass="84629" checksum="E3CAD9996F57D37A" modified="2022-01-19" version="1">MLETDTSIKPTSDEATAQSPTTPTSPTHSNSRYSTHIVLTTYPGQSGIDPIPLEWGAPDAKSRGPVVVSRSSALLKRRNAMGAHGGSYSIYNALAIAAGDLEPNFRPDLSNSQPTFNFPWQPAWADKTKIVSMDPWGHDIVNQFRDELSKGWDIRPTMAVTRANMNFAEIADAVKEGKLDVDGSIVVDSSGEVRVTKVAVEPVWYLPGVAERFGVDEGTLRRTLFEHTGGSYPELITRPDLKIFLPPIGGLTVYIFGPPERVSDENVKLALRIHDECNGSDVFQSDICTCRPYLAFGIREAIREAQSGGSGVVIYFRKEGRALGEVIKYLVYNARKRGGDTADKYFTRTENIAGVRDMRFQALMPDILHWLGIKKIDRMLSMSNMKHDAIVESGIKILERIPIPDEMIPTDSRVEIDAKINAGYFTTGKNVTAEDLAAVRGRGWEKWEDITSLSITMGSSVTVTPQPRIPKAGVWCPAVTFFDHSTDTLDLDAQKKYYQYLSTTGLAGLVILGTNSEAFLLTREERAQLIATARAAVGPDYPLMAGCGAHSTKQVLKLAEDAAAAGANYILVLPPAYFGKATTPAVVKRFFADVARKSPLPVVVYNFPGVCNGVDLDSETITAIVRESAASSANGVSNVVGVKLTCGSVGKITRLAATFSKEEFAIYGGQSDFLIGGLAAGSAGCIAAFANVFPKTASKIYDLYVAGKIQEAVELQRQAALAESPCKSGIAATKYAAAIFSARAAGIEGAEEKLKPRTPYEEPAEGAKKGVQDLMSAVAKVEGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0C8</accession>
    <name>A0A8G1R0C8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_399470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514248.1">
        <property type="nucleotide sequence ID" value="XM_025657097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0C8"/>
    <dbReference type="GeneID" id="37160499"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR PBCR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH56326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="720" mass="80112" checksum="4AB17EFF17CD12ED" modified="2022-01-19" version="1">MSASMPSSYRSLNLPNSLPPLNQSCENCRALKVRCLPDPNVPRQCQRCTRTRRTCVFARTLRRQPRKKTGSRVAQLERDVRDLRSLLHDQIRPDSDRGGKADDAAAAAVATDPPGASGRDVAPLPALSSSTRIEPPIVHNASAQGDSDQHTGNPPAEPAPANSSLTLMQSPAGSGDVVDRGIVSLDMAQTLVSFFINEQMQFYPMIVLPSNTTAESLRRTSPVLFLSILAASSMTLNPHLAETLNEEMLKVYAERFFLRQEKSVELIQSILLMLIFYFPPKSRLQGQYYQYTHIATTMTLELGIAAGPAGRKNYRCHGGYGDLPASIHSAQARAVLGCYHFASNIGIRTHRPNMLRFNDVIDGYIHHLRESTLGLDQQIATWFGLQRIVDDTLSSLGQDNTLVDISLRESQMLPILNWFDSRMLHWKRTTPKNMLTTWMNLEYHHMYLAIYELAAGESYRDPDAPTRKYYTLPPLEGDMERHKANAPITAARVQIITKWLLASHQMLDAFLGCDTSTMRKLPNMTYTRMILGISSLLRIYHTAQFGPLGEVVSSQMMDVDGYLDRVGQALLRASGEQKYRVPSKWYHVVAIKNREWFEQIQKRIIARPSDTHTYLRGGVPPPASGVPMLDPHRGPGSAAILPSLGGGMAGPAYAEPWYVDDAAGRVDLSRSFPAVNAPVLYMGQVQPVEGDIGENAFPLPVGDEPWRLDESIQDSVSFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1F3</accession>
    <name>A0A8G1R1F3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pfs, NACHT and WD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_514157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515329.1">
        <property type="nucleotide sequence ID" value="XM_025664745.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37168147"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031359">
        <property type="entry name" value="NACHT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17100">
        <property type="entry name" value="NACHT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NWD NACHT-NTPase N-terminal" evidence="5">
        <location>
            <begin position="100"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="6">
        <location>
            <begin position="392"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="817"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="858"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="988"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1071"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1113"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1155"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH57407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1324" mass="149891" checksum="D1A9D636C0C90DB6" modified="2022-01-19" version="1">MYSSIKTGFRARVRQKLEAFRGKPRKQSTQAEGPHTTNDSTSPTQGESEYHDTAKVVEENGHVPPSGATQQEKPQANENVLDHSNQKVASTECLTTIHNTLWNKAYNKISQDPKKAKYLQAYEKLVLAVFLETPISDAAGEGISPRLDLEEERMRAIVARALKRIEDNKNVMETMNDVSGVLTQVKAFLDIPLQSIPQTALPWAVISSTIDILIRPVKAAADLYNGVAYVVSRMSWYSKAVDKLLSDQNIKNNTSLGEMNHSLEARIVDLYESMLFYQIKSVCFYYKSQLLVLLRSFLDLDDWSGNLNAVKDAEKVLQSDFTLYNQEHIKDQIRQITIASEHQKDLDEYRNSEIGDIQARNESIIEELYTWIFLTNEYRQFSKWDHITPARLWMLGDKCLKRAIIIIDAMDECEEKSRELLTRFIDDASSAEELLNIKWLVSSRPLPEIPASVQDPTLPTHSLLKLDGHDMSHSIDRYIDIKMVQLRHKARKKNRVEELAAKLKAEASNTYIWVSLVCRELINSHEFMWAEIVDKIPKDLEDLYGYLLDRLANLNSEIMSSCCRNVLMAAMVARDPLALSEIEILAELPEGEDTAEAVVQECRSFLTIRNNTVYLVHQSAQDYLQKHYRRLYNVSSATLHHQLYKRALHGLRKNLKQNIYGVSHYGIAIQDVQIPNPDPLNCIRYACRYWVYHLVQSGCTSTDMEDILSFFNTHFLHWLEAMGLLGLFPDIVRLVGQLKSSSETKNVPVLLDFLMDAERFILQNLPIATAAPLQLYVSCLIFSPERSIIRCMFRKKVCKWILRTVGTDMEWGALLQTLEHSNRVCSVAFSTDGQLVASGSSDKMVKVWDSFTGNLQKILDHPSWVRAVAFSPDNKLLASGLSDGSIRLWNTITWRETGRLEQSGDIAHLMFSLNNQLLGSASFNGVVKVWEKGTWRLRWEWRPSGSTSSLAPTAISLNGQGLLAATIRAYAPNTVVLVNIESDTIVHELAHLGKITNTAFSLDNRMLACTSDDRTITLWDTATWNIKHTIHDEHVLDLTVFSPDSNLISAGPLQNSVQLWSTKSGTLEQTLKGHVNHATTVAFSPDGQLVASGSYDNTVKLWKVAPGREEPSMDYHSEPIEGVILSPDGRLVATYSLDFTVKLWSAENGRLVRTLKGHHDEVTAAAFSPSSKLLASSSSDRTVRVWNTENGQQKWKFDHGSKMLCLVRFFAENQVLATDFGKNTFRIWNTQTGHPEQTGGIYDPRIRSILPTNPTKQDMSAKCKISVEDDWVILGNKKSIWLPPEYRNNEFDNAWANRENALIIGAQSGRVYFVWFDPDALKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R219</accession>
    <name>A0A8G1R219_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteasome regulatory particle subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_468704</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516045.1">
        <property type="nucleotide sequence ID" value="XM_025662286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R219"/>
    <dbReference type="GeneID" id="37165688"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="266"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH58123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="488" mass="56622" checksum="7BE331AD32EBF189" modified="2022-01-19" version="1">MSETLLKPEKDFSKDADKLIPEAEQLAKTDVQGAIDKLLVLEKQARQASDLATTSRILITIVTLSKNSGDWNLLNDQVLLLSKKHGQLKQAVTKMVQTVMGFLDETPNLEVKLSVIHTLRTVTEGKIFVEVERARVTRILSDIKKTQGDLNAAADILCELQVETFGSMTRREKTEFILEQVALCIERGDWTQATILSRKINKRYFNRKPKKSPEEIEKLKKEAEEKEKTRSPDEAPMEVDDDVTDLKLRYYEQQIILANHDYKYLDVCKHYREVLDTESVENNPEQLRAVLARIVYYVVLSPYDNEQSDLLHRIQQDSRLSLVPVEGRLVKLFTIHELMRWPMVGEQFGPHLCNTDVFKPQPSQSVEDQPYRRWQDLRKRVIEHNVRVVAKYYTRIQMGRLTELLDLTEEETEKYISELVCSKTIYAKIDRPARLVNFAKPRDADDVLNEWSSDMKSLLGLLERIDHLITKEEMMARILPTREKGKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R259</accession>
    <name>A0A8G1R259_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_478784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514337.1">
        <property type="nucleotide sequence ID" value="XM_025662912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R259"/>
    <dbReference type="GeneID" id="37166314"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="29"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="347" mass="37786" checksum="91BD389039FFDA34" modified="2022-01-19" version="1">MTPPDVDIGYKLLVGTTVTFVSACVVVVLRAVARILYASLGWDDYMMLFAVAQALVATICDFLAVNHGLGRHMVYLTKKQIPPLMFWDYLGQVFCVNALTFAKISICLSYLRILRGSHQRTLRVLCIVTAVLVFAVNTVVIISFYARCNPTHKSWDPYLPGTCWPAATETGLVILQGSFSALTDYFLSAVPIFLFKDLQISRKNKIVLCGLMSLGAVTGIFATIRTVESGESLTGSSASDSTYTTVMGLTWAGMERNIAMMIASVPPLRPLAEPVVRLTSNTFSNLISSRRTQNSYELGSQAIIQSPGLGTPSKHYASAKQAALAKDDRSTSLEHILPPQVNTTSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2U2</accession>
    <name>A0A8G1R2U2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Histone-lysine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_296283</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516064.1">
        <property type="nucleotide sequence ID" value="XM_025655306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2U2"/>
    <dbReference type="GeneID" id="37158708"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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            <begin position="328"/>
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        </location>
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            <begin position="617"/>
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            <begin position="1"/>
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            <begin position="40"/>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50280"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="RAH58142.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="852" mass="94161" checksum="CD90044627EBE75F" modified="2022-01-19" version="1">MEGRPGSPGASPATPATLSDLKKHTHEHLEGTMAFEYTEQLLTPENSRSETSSNNDNASTDEKPTLRRRSTRVTRASLRGAVQLSDHLDADNHGLPSPADESDRTVSGDVLASAVEAAEVKRTRSKSSSHLRHSIAVMETALWSETTLPQNKEDGDDHPMAPDTPVSKSSQEPQPNDIGMSLQQRTLRKRVEKVLTQEDNKDQEKVSAPAKPERRKSLRRSTRLSILDKASDLVGRASSVLGKRSRDKVEKSSGPDRRASLRPRNVAALKEEPPAPTPSAPAPKKRRVSESDLPSKTQSTEEPPQEQSAPAEPVPRLKRKLWLAHGLYTGQEHTDSPPVQSRNRSRRKSQTQSQTQSQRKLLPLPMFAGDRLLKNGRDFQLPFDVFSPLPPGQPKPDEWRKTNKNVFVGEAGSIWRANKHCELSKCMCTPETGCDEECQNRYMFYECDEGNCGVGEECGNRSFEELKQRTKAGGKYNIGVEVIKTADRGYGVRSNRTFEPNQIIVEYTGEIITQTECEKRMRTIYKHNECYYLMYFDQNMIIDATRGSIARFVNHSCEPNCRMEKWTVAGKPRMALFAGDRGIMTGEELTYDYNFDPYSQKNVQQCRCGSSNCRGILGPRPKEKAQRAKEQKVEKPKKSASRRTNGKTAGTKRKSGDALDVSSSRANKKQKLAVAKSIKSGVKKAVSRARATVTKTTASRTKQAKKEKGSPAKRTAAKATKTTRSPTKKTVTKKDEPKGKSNIKLPKVKATKVKARATVPKKSAQTAKGKTQNAAPSSSKLSRPSAATKAKILAAAKGTNPRRKSTKKDDTKTDHKTTAPKAQKKTQAPKQEPKSKGAIKRTGTAATKGSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2V0</accession>
    <name>A0A8G1R2V0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HPP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_373793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025656098.1"/>
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        <property type="entry name" value="HPP"/>
    </dbReference>
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        <property type="entry name" value="TM_HPP"/>
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        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
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            <begin position="123"/>
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        </location>
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        </location>
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        </location>
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            <end position="244"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RAH56760.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="293" mass="31946" checksum="6D691C77A04B795B" modified="2022-01-19" version="1">MSAQKPQSGSLLQRIDFSRLHVDIDAFLNPYLPPPPWRHLPRPISRFFGYRKTLAPKPLGNLVIAFWSMIGVFCGVLVVAEVSEHVPSFKAHHAPIIVASFGAAAVLEFSAIESPFAQPRNAVLSQIIASFVGVVIGKLFALNANAHSMPQVGGALACAITTAIMTITNTVHPPAGATALLAVTQSYDVGWYLIPIMLLGCVLMQAVALLINNIQRRFPIYWWTPQSLERPKPDDTESAREAKEGSVASVQSHDTFPGVPTHIVIEKGSVMLPDNITVTEQEMVVLKRISERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2X4</accession>
    <name>A0A8G1R2X4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BO85DRAFT_488964</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514712.1">
        <property type="nucleotide sequence ID" value="XM_025663572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2X4"/>
    <dbReference type="GeneID" id="37166974"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH56790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="299" mass="34195" checksum="6D970CE19E326361" modified="2022-01-19" version="1">MSATVYSEVTDIDGLIPTDTDIKYRNSSDVKRLIPWVFKHHDIAKANCTRFWPKEESKYRDFFYHFSCYRAELNELDPVQIPVFLRPGEKITLPRQNWETPGRAPQFLQSQGMMLKVLMQAIYDNLENLPENRSELYFPVSGLKKRYVIGGKRYASRPEGAVVVKSQGLSVPIVSYVGWLEGQTSQDFLAENLSIMLGQLAANVSIDHQDQEVFTLGLYGSSIYISRGLFTTTQMEQVHSKGCSENETFHLRFSRGYNLSLHKDWLEAMHALSRLLRYLMSGNAKIGAIRTHVPNSDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R341</accession>
    <name>A0A8G1R341_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bys1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_520142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515296.1">
        <property type="nucleotide sequence ID" value="XM_025665106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R341"/>
    <dbReference type="GeneID" id="37168508"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF5">
        <property type="entry name" value="BYS1 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G04533)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034059061" description="Bys1 family protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20649" checksum="C4E7A10BE282C7B5" modified="2022-01-19" version="1">MKPTILLPLLLRLATTHPTPQDTITPSTITPGHAIILNTCAFPIYAWSVSSIVGPQITIPAAAPITSSSSNSNSTTQQYSNYTEPYHHDAQTGGVSIKLTTLRNGLYTGAPQTIFAYNFVEGQNQVWFDLSDVYGDQFKGRRVSVQVRVVQGGENSGGWEESIVWEDGVPVGGSQVRVVGAERDLVVRLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3B7</accession>
    <name>A0A8G1R3B7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c oxidase-assembly factor cox23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_449715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH56985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514907.1">
        <property type="nucleotide sequence ID" value="XM_025660213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3B7"/>
    <dbReference type="GeneID" id="37163615"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051040">
        <property type="entry name" value="COX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH56985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="87" mass="10170" checksum="F986D49CC35BCED1" modified="2022-01-19" version="1">MASQSDKQPTPSDQTNPNAWERVERKFTSKPASEYFDPCQDFADRSLKCMKRNGFDKEMCSDYFQAYRDCKKEWLTQKKLGSSAAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3E0</accession>
    <name>A0A8G1R3E0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_487432</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516641.1">
        <property type="nucleotide sequence ID" value="XM_025663453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3E0"/>
    <dbReference type="GeneID" id="37166855"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH58719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="186" mass="20869" checksum="66E5578FD50C6E82" modified="2022-01-19" version="1">MVYIMKIHVDGGCRANGQPGSIGAAAAAFKSASGRFYGETTEDLLSYTAPTNQRAEITSIILGLRMALKKSEQLVSDPRLDVTIYSDSTYAVSCMEKWIYKWIRNGWLNRKGVEVANRDLLEKAVVLDSRLKQKGDVQYVWIPREENQYVDKLCNDLMNTICLVERLCNSLKNARCDVQSSSSDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3S0</accession>
    <name>A0A8G1R3S0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4139 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_487780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515879.1">
        <property type="nucleotide sequence ID" value="XM_025663475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3S0"/>
    <dbReference type="GeneID" id="37166877"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005:SF8">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4139" evidence="1">
        <location>
            <begin position="18"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="169" mass="19034" checksum="5002C5C200AB79CB" modified="2022-01-19" version="1">MRSGEVNLTVDGTCFGKTNVPSCVRNEFFELNLGVDRFVKVAYKEPGITLSKIDEFLELTITYFKATCKIKNTRDHAVSVLVLDQVPVNVDDHFDVEILTPETLGFPGDKVDLTEPGKPGTKTAELGRDGEVRWEVTLEPDEEIELDLRYSIEAPFEKWGRDFPVPVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3T3</accession>
    <name>A0A8G1R3T3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_398624</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515147.1">
        <property type="nucleotide sequence ID" value="XM_025657061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3T3"/>
    <dbReference type="GeneID" id="37160463"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000007">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="17">
        <location>
            <begin position="677"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH57225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1053" mass="118069" checksum="64133311C7509928" modified="2022-01-19" version="1">MFRSTAVKATSGLRSPACSSCKRSLSLAATARSAANGSKLGLTARRPLALVDRLSKRHYAAPAEGVDANDSFLSGNTANYIDEMYVAWKRDPSSVHISWQTYFKNMEEGNMPVSQAFQPPPTLVPTPTGGVPQEMPGAGLSFAAGTDVTNHLKVQLLVRAYQARGHHKAKIDPLGIRGEAEAFGYNKPKELELDHYGFTERDLDQEFNLGPGILPRFATEGRKKMTLREIISTCEKIYCGSYGVEYIHIPDRKPCDWIRDRFEVPEPYKYSVDDKRRILDRLIWSHSFESFLATKFPNDKRFGLEGCETLVPGMKALIDRSVDYGIKDIVIGMPHRGRLNVLSNVVRKPNESIFSEFAGSAEPSDEGSGDVKYHLGMNFERPTPSGKRVQLSLVANPSHLEAEDPVVLGKTRSIQHYNKDEQNFDSAMGVLLHGDAAFAAQGIVYETMGFHSLPAYSTGGTIHIVVNNQIGFTTDPRFARSTPYCSDIAKSIDAPVFHVNADDVEAVNYVCQVAADWRAEFKRDVVIDIVCYRKQGHNETDQPSFTQPLMYKRIAQQKSQLDKYVNKLIEEGTFTKEDIDEHKKWVWGMLNDSFDRSKDYQPTSKEWLTSAWNGFKTPKELATEVLPHLPTGVEGPLLKNVAEKISGGGSPDGFTLHKNLKRILANRKKAVDEGQGIDWATAEALAFGSLVSEGYHVRVSGQDVERGTFSQRHAVLHDQETEGTYTPLQNISENQGSFVISNSSLSEFGALGFEYGYSLTSPNALVMWEAQFGDFANNAQCIIDQFIAAGESKWLQRSGLVVSLPHGYDGQGPEHSSGRMERWLQLCNEEPRVFPEGDKLDRQHQDCNMQIVCMTSPANLFHVLRRQIHRQFRKPLVIFFSKSLLRHPLARSDIEGFTGDSHFQWIIPDPAHGKEIDEPEKIERVILCSGQVYAALTKHREAHGIRNTAITRVEQLHPFPWAQLKENLDSYPNARNIVWAQEEPLNAGAWSYTQPRIETLLNETEHHNRRHVLYAGRAPSASVATGLKSVHLKEEQEFLNDAFTVHQERLKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4B7</accession>
    <name>A0A8G1R4B7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_448482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516348.1">
        <property type="nucleotide sequence ID" value="XM_025659942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4B7"/>
    <dbReference type="GeneID" id="37163344"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="476" mass="53200" checksum="E2D95D0DC1777797" modified="2022-01-19" version="1">MSWTKQTDHWSRPLDCHDRLFQFIGESGKPLGREHWLTIGAIQLDFPNNNNNTDKIITQLRNAWKSLRMRYPDIAGELHAHEKRYYPITSPEALESWCNNTFKIEDAAQSADDLFTNKLHITDPHATAHWIPSSQEFCIVSAHWRWDGSGLAMVLDQFLSELQAPSITTTTTSSFDGSEATRLIPSLDAIIGMPASPEARNPEWSRRADELLATFLEGQPSIGLPVLDPMALPAKSLRTEHVVPADQATALRRACRARNITLTTAMHASAIIETARAAAAAAAANSTNLSSRYISWQAFDLRKYLPPPYDGPIHGPSLRMVGLPLNVEATPTTNWSDLVETIQPLYRQSWNLADSNMMFIRAPFVEKATAMFQAAAAAGASQPTEPNINSLGPIDRLIRESYGDVKVKGLVLMVQMLAQQLYVHCWSWRDELHLSASYNEAYYEKGFVEEWLKAMKENMVLNLLGEEADTNKGALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4E7</accession>
    <name>A0A8G1R4E7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_511989</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517196.1">
        <property type="nucleotide sequence ID" value="XM_025664628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4E7"/>
    <dbReference type="GeneID" id="37168030"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="6"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH59274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="150" mass="17100" checksum="443F1919D30C6C4B" modified="2022-01-19" version="1">MSLPSGVSITAECINAYKELLYKRGAGKPAFVIYKISDDEQSIMVEECSPEKNYEAFLQRLTSAHDNDGKPAPRYAIYDVEYDLNEDGRRATTVFISWMPDVTPTRIRMLYASTKEQLRRALDVKVSIHADDLHDIEWKIILREASGGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5M3</accession>
    <name>A0A8G1R5M3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_418211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517023.1">
        <property type="nucleotide sequence ID" value="XM_025657807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5M3"/>
    <dbReference type="GeneID" id="37161209"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="422"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="949" mass="102482" checksum="225AA2F38A686C24" modified="2022-01-19" version="1">MTVKEETFIPLYRSSSSGRPRSRTIRQWQLPICAGICAAAILLVGANPRELLLSTSATTHHEFYTGLQQCYDAERQLHAPDDGASSRRNNPRWNPVSGPATPVVIQNATLFDGESTLPDAVDIVFEAGVITSVVSTGSGDALPANANIIDVHGKHVTPGLVDMHSHHLVMPFPQVVATSDVNEKSLGPITHFVRAIDGFTPSDPTIKIIASGGITSSLVLPGSANIVGGEAYPVKNLPLSGEHGESVIEELLLEHGIPEQDRQRYLKMACGENPKRNYQHTRMGLAWLLREKLAEARELEQHQAAWCRGALEIEHTRFDRARHISRFLEQQGRRPDSFELSTFVSLIRGELNVNVHCYTPEDLERMLAVLHEFGIHPRAFHHALEAWQVPELLKHLEPNVTVATFADNALYKAEAYEANLRAGKILNDHGVRVAYKSDHTGEENYAKYLLDQASIAHSFGLPADKALQSVTSVPAHSMQQDHRIGYVRTGYDADIVIWDSHPLQVGATAVEVFIDGRALLQKQDITEISSTSGFDDLQRVPEMRPVADLDQRINVCSKPRLVFTGIQKALIDRPSLDQVAEQLVLVVEDSKVSCLGAKQTCIRGEDEGVTEVALNNGYITPGLIAFGNDLGIQAISSEESTGDGSSGTTGDLLNEAKSVHFAKYGAHLHGVAFDRARIGGVTKAITPPYGSGLIKGVSVGLRTDPNATILDGGIWRDDVALHFSVGQGAKNGDTPTVASEIQALRQILKEGSKSDAEQHSVYAQAANGSLPLVVETYNEDDISQLILVKREFPSVNLVIYGGHGAALVAKPLAEAGIPVILTGNLGAPDKWEKKNALPGPPLSDSSAKVLIDAGVQLGLALQGDSRLHGLAREARWAAKQAGLSDKEAVALVSSNIERILRLDRAINDSQAYVGDLVLWDGNPLHGEGSVVVAVGEDAGVTDCWPDSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5Q7</accession>
    <name>A0A8G1R5Q7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C6 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_369084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517068.1">
        <property type="nucleotide sequence ID" value="XM_025655900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5Q7"/>
    <dbReference type="GeneID" id="37159302"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="782"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH59146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="861" mass="96607" checksum="68B043221CAB7154" modified="2022-01-19" version="1">MEDINIPSPSAILDVQRPYASAAGHFNPSVSPKNSTAGQRGAAKDRSKPKQTKSRNGYIKKFKWRNGFGQKNFVGGTNGSANTKKAIQYQSNENPSTENSGSPIPQNQSRASKSQQAASSLPCMGSGSFMDFADLPSKNASPSKRTNRRSFSDKDSFSNPDEFIGQLTPVSFNEDILASSLTDISPSDQISWISDFSLAAVEQRPGNGREPKRDLGRNNSFAEEGFSFEELMEVDDEDIEEIVRRPDRSMKSGRPENADMNIAPHQELFNICREPNLGIASPEMLVLQFDRVTCGILSVKDGVHENPWRTLIWPLAKETPALYHAVFSLAAFHSSKEFPALRVHGVDHMRQSITHLVHDIRNMRVDAALATSLALAFADTWDQHTRTCIQHLKGAKALVSQVVGLGAQGEIRGINLSRVRFLYNTWLYMDVIARLTSREESGDQEVNAPFFQLPSHAVHEIDPLMGCATTLFPLINQVARLVQRVRKTTSNSISLISQAIELKRLVEQWEPPQFFEPPEDPSSEVQHSIQTAHAYRWATLLYLHQAVPEMPSEPTSELAKRVLILLATVPSSSRTLIIQMFPLLAAGSEAEQEDDRQWVLSRWESIQTRLMLGSIDRCIEIVREVWARRDAFEDEKQRLRGSSGRGITSVMENSANDRVPLTSLRPNDQMVRSTYAKEPWRRTIQEEWLASKATIGNSRRSSAMSPLENIEFEKTVRGKLHWINVMQDWGWEGMCELLLVVSLSLLCYSYLWRTPAHSYSVPRLRPVLVCSTRAHLHHRAGAASTIVILASFPTWLLSLSLLVGIARAGIRLGIFGWILCWRSWGLILSQIRSEGCQIRLQITRYGHRSSHGCEGCAMIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5X7</accession>
    <name>A0A8G1R5X7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase Rpb4/RPC9 core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_436324</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518608.1">
        <property type="nucleotide sequence ID" value="XM_025658571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5X7"/>
    <dbReference type="GeneID" id="37161973"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.40:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="4">
        <location>
            <begin position="29"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH60686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="148" mass="16848" checksum="F997C5B68041FE17" modified="2022-01-19" version="1">MSVQLPPATHRKRTLPQGELEAASTLKLGADQNTHTLSLSEARLVINKVLENKRRGGKKYEEPENLTKTLDYLEVFARFKDEENIKAVERLLNSHTELEMFERSQLGSLCCDNAEEAKSLIPSLQHKISDGDLQELLDELTKLRNFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5X9</accession>
    <name>A0A8G1R5X9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_468839</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515322.1">
        <property type="nucleotide sequence ID" value="XM_025662297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5X9"/>
    <dbReference type="GeneID" id="37165699"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH57400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="512" mass="57892" checksum="B8A80D0138161E0A" modified="2022-01-19" version="1">MSSDSLSFLTWGALSVLAWTIYGAIWRLYLSPLAAFPGPKIVALTSWVEFYHDVVKKGTYMWEIEKMHQKYGPIVRVSPYELHCIDPDFYNVIYASLPQKRDKYEKFTKSPDCNNATGFTVEHAHHRMRRDALAPFFSKRNTLGLEDSIKACVDQLCANIARAHAAQEPFNLTLGSIATTMDVLTSYSFGQPFGLLADEALATQWRDTVFHIMRALPIVRAFPLLVRLVDLLPPIISKWITPDLSILMGWKQRIRKQTEDVLAYRGIYSDPDRKATTVIEALRDSDKLPPKEKTLQRLSEEGAILLIAGSETPAKVNAVLWYHLLANPTRLQRLRTELASIYPDPKHPLPSVTELEKLPYLNACILEGLRLQSGVSGRSHRLAPTSLSYGNWTIPARTPLSSISVFQHYNPVRFPDPQAFFPERWLLEDGSGIRMDLKRSLVAFGAGTRYCLGTSLAYAELYLMAAALATRVDMELFETTVDDVKIMLDWTIPQPKPDTQGVRVKVRAVHMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6A7</accession>
    <name>A0A8G1R6A7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_478040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515502.1">
        <property type="nucleotide sequence ID" value="XM_025662867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6A7"/>
    <dbReference type="GeneID" id="37166269"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20661" checksum="0B2C6422098218DE" modified="2022-01-19" version="1">MARLPYPEPPKQHAKSHPTLNIMKLLSYSTATVDHWAGLGNAQFKHLSLSARHRELVIMLTTSKFNSTYEWTHHIPVSLKAGVTEQQQAALKASAKEKNFFIDRKFDNGAAGFSDKDLILLSFVETIIQQPEVSDELWKSVKGVFSDREIVEIITLQGSYYSFSRLTTVLQCDFDDWAKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R718</accession>
    <name>A0A8G1R718_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Geranylgeranyl diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_365054</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519208.1">
        <property type="nucleotide sequence ID" value="XM_025655724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R718"/>
    <dbReference type="GeneID" id="37159126"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH61286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="389" mass="42778" checksum="6C0D0266A214385E" modified="2022-01-19" version="1">MSAGPVSEISASGPPHPGLYFLAGSSIDGTGAASLGKPDLLVSPAMDHASSNDDGLATNTNHSRMHNRNRSSVDGTKYKDGQWSPENERIVMGPYDYMLQHPGKDIRRQLINAFNMWLKVPPESLSIITKVVAMLHTASLLIDDVEDNSILRRGIPVAHNIYGTAQTINSANYVYFLALQEVQKLNNPAAIDIYVQELLNLHRGQGMDLFWRDTLTCPSEDEYLEMVGNKTGGLFRLAVKLMQAESSSGKDCVSLVNVMGLIFQICDDYLNLSNTTYTKNKGLCEDLTEGKFSFPIIHSIRSNPGNHQLLSILKQKTKDEEVKLYAVSYMESTGSFAHTRDVVRELRAKALTLIQAIDGDQADGREDGAMVRAILNKITESTLGECGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R861</accession>
    <name>A0A8G1R861_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_446262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519020.1">
        <property type="nucleotide sequence ID" value="XM_025659466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R861"/>
    <dbReference type="GeneID" id="37162868"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="430" mass="47585" checksum="699082AD6888C6BD" modified="2022-01-19" version="1">MLPTRGIALRGHKSSRSQALASQICQLSAPPAPLHQSVRSYASSPLTRNARPGQLRPQRSPKSFLTSTTYAPIRRRFESSKSDHLTPADFEEAVDQIAHECAELSETDSVPPNDGVVQLLQKCQRIAEAMVHPEQDTGKSQQPDEISSLLDLEEGKNAATRKQKQQTTTTLPRKTPEQIIDQLCKSVHDLLTDEKVFISPEALTCYTKIHAMLKRPDHFPEIFHLYANKPVPEENSSPVRYHKAKPKSINSAVPVELADMALDVAIAQRNLSLVLAIIDTTYSTPAFRRAKVFKRAAVPLGGIAAAPAACYTLASWASTLQNTMDPSTATGIAFAAGLAYMGGVTSVGILAITTANDQMERVTWQPGVPLRHRWTREEERAAFDKVALAWGFKDIYMRGEEEGEEWESLREFIGMRGMILDRTELMPGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9C7</accession>
    <name>A0A8G1R9C7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_412279</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519605.1">
        <property type="nucleotide sequence ID" value="XM_025657562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9C7"/>
    <dbReference type="GeneID" id="37160964"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="23"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH61683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="286" mass="31912" checksum="90B5937294CE6202" modified="2022-01-19" version="1">MTAKWQVTRLLHGVRAIVGGQGPPVVLIPGWPQTAEAWSDMFEPLSRNYRFFALDPPGLGDSLPPANGYDTANVSKIMAEAIHDALKEQPYHLIGHDVGGWIAYPWAAQFQSKIKSLSILDASVPGFLPQFQFPLSQQTNLRLWQFSFNALPELPEILTSGRERELLTWFFNLKTVHPDGMHKDHFERYIQVYSRPGAMSRGFEYYRSFETSSKQNLEFAKTPLDIPVLALGGESSVGAGMIDLVQKFAANVSGGAIHDCGHFLPEEQPSAVAQRLLEFLDANQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9Q4</accession>
    <name>A0A8G1R9Q4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_395014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517257.1">
        <property type="nucleotide sequence ID" value="XM_025656942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9Q4"/>
    <dbReference type="GeneID" id="37160344"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="148"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="565"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH59335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="597" mass="64799" checksum="7480EEAD0447218B" modified="2022-01-19" version="1">MAPTPVLATSAYYAPGVVSSASKYLHVSGQPGTIEGTAPADYISQIHLALVNLHRVLAATGATPRDVVKLTLYIVDYDPNNRLHTRPLQTWLAGHKPAITLVPVPQLAVPDWKFEIEATVAVPDSVPTSLSLPSPTETTDVLIIGAGLSGLMAAETILQSGHSCIVLEGRDRVGGKTWSCPLPSGTGVVDLGAAWINDTNQSMMYELAKRAGAELIEQNTTGNCVLQREDGTLTAFPYGQTPCITPQIQKEIELIRDTAELDCQSLSTSRPQNAELDSLSFLAYLHSRNASPIAVANASVWTRAMLGQEPQDISALYFLNYCKSGGGLLQMRSDRKHGAQYLRVRQGTQIFAKTLAESLPTDTIRFGQRVVGITQVQKGVNYVKTESGLVVKAHKVICSVPTPVLKTIKFEPQLPAAKQLLVDSFRYGYYTKVMLSFRTAWWADRGFCGLAQSFVGPASIYRDTSVPEDGKWVLTAFLAGDAGRKWSGLGSQRERELALLEQLGAIYGDKDLPKREFVEALGHEWSTEELSGWGCPCPALPPGVLMLAGDALREPFRDVHFVGTETAEEWKGYMEGAVRSGKRGAVEAVKGLTRSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA62</accession>
    <name>A0A8G1RA62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="10">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_483979</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Also plays a role in response to carbon starvation and the control of extracellular proteases activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with creA, creC and qutD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="10"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519889.1">
        <property type="nucleotide sequence ID" value="XM_025663203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA62"/>
    <dbReference type="GeneID" id="37166605"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000075">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase creB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="57"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="515"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="573"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="677"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="714"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH61967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="759" mass="85100" checksum="EA69212BDBACB031" modified="2022-01-19" version="1">MGSFLRSFRRDVGSSTPSVGATPAKKEPLALPMTPLEKMLQEMGSDSVRQDGSDKFFGMENYGNTCYCNSILQCLYYSVPFREAVLNYPTRTPIETLEAALAKNLRYQNFAANQEAEAQAEKQRLANAQRPGAPPAQPPKPEDKDSSEYKKKIALQSLPLLETKNNAGSYGMSESLFTSLKDIFESVVASQSRIGIVRPQHFLDVLRRENEMFRSAMHQDAHEFLNLVLNEVVANVEAEAMKQPIPSLPPADTTDSSRQSISSGSKTPNTTRWVHELFEGTLTSETQCLTCENVSQRDEIFLDLSVDLEQHSSVTSCLRKFSAEEMLCERNKFHCDNCGGLQEAEKRMKIKRLPRILALHLKRFKYTEDLQRLQKLFHRVVYPYHLRLFNTTDDAEDPDRLYELYAVVVHIGGGPYHGHYVSIIKTQDRGWLLFDDEMVEPVDKNYVRNFFGDKPGLACAYVLFYQETTLEAVLKEQEMENMNASAADANEAAVKPNGFPHPSGLAHVHSASQIPVPDEPQRHTGLRRAPTAPQLPTHTEYTGPDIEPSSPAVATPPPVPPIPETVNRPLSPKKSDIQSKKERAKEEKERKAAEKELEKQRRKEQEARVKENQRREEAELKAALEASKASKADEDRRNPTENGKDGDPKKTSNGLSRLKRGSKSFSQRLGKDKESRASSSSGLPSVPSAEPLTPRQPPLEPVQPLSPRTTSPPKESHIVHKPLGRDDEPDALKSPKGDRAGHGKWRSFSIRKKSFSILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAN3</accession>
    <name>A0A8G1RAN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6 18">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO85DRAFT_486259</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 18">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6 18"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517722.1">
        <property type="nucleotide sequence ID" value="XM_025663377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAN3"/>
    <dbReference type="GeneID" id="37166779"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000023">
        <property type="entry name" value="3-isopropylmalate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012235">
        <property type="entry name" value="3-IsopropMal_deHydtase_ssu/lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001418">
        <property type="entry name" value="ACN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 18" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="19">
        <location>
            <begin position="13"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="20">
        <location>
            <begin position="537"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RAH59800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="773" mass="84059" checksum="814D871FC0CE4739" modified="2022-01-19" version="1">MPGADRKPKTLYDKVLDHHIVNEQEDGTLLIYIDRHLVHEVTSPQAFEGLKNAGRKVRRPDCTLVTVDHNIPTSSRKNFKNVDEFIKENDSRLQCSTLEENVKDFGLTYFGMGDKRQGIVHIIGPEQGFTLPGTTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLITRRSKNMRIQVDGELPAGVTSKDVVLHIIGVIGTAGGTGAVIEFCGSVIRSLSMEARMSMCNMSIEAGARAGMIAPDQITFDYLKGRPLAPKADSPEWTRAVNFWSSLASDEDAVYDKTVIIDGKDIIPTVSWGTSPQDVIPINGVVPGPDDFEDENRKLACKRALEYMGLTAGTPMKDITVDKVFIGSCTNARIEDLRAAAKVVRGKKIASNIKRAMVVPGSGLVKQQAESEGLDKIFTDAGFEWREAGCSMCLGMNPDILSPQERCASTSNRNFEGRQGYGGRTHLMSPAMAASAAIVGKLADVREHLTSSPVLGKVQPKIDVQEQLHEEPTTEDEVERIMDLPADNEPHTNSSATATSSAGLPKFTTLKGIAAPMDRSNVDTDAIIPKQFLKTIKRTGLGSALFYELRYKDGAEDPSFILNQGIYRNSKILVVTGPNFGCGSSREHAPWALLDFGIKCIIAPSFADIFFNNTFKNGMLPVVISDEAVLAKIAAEAHAGREVEVDLVNQQIKDVAGNKLADFDVDGFRKHCLINGLDDIGLTLQMESKIKNFENKRTIETPWLDGSGYLKRGNRGGATMVQAAPVPKTNRGDVKSEPLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBB8</accession>
    <name>A0A8G1RBB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_501696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519978.1">
        <property type="nucleotide sequence ID" value="XM_025664177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBB8"/>
    <dbReference type="GeneID" id="37167579"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="187"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH62056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="356" mass="39515" checksum="0401C2FB64381F54" modified="2022-01-19" version="1">MPTQEFFNRVPPFPSNIPTAEIPLISFKDLANASATESKKLFQACRELGIFSLDLRNSGTGEQLLKDAEALMNLTTTTLSLDRQILDKFAYNPPHNIAGYKRSGKLRTADGKLDSMETYSISQDDMVGNVPPRENPEPIEHHRTECRAFFEHARTTLEVIYAHLEENLGLPPNTLAERSALNKQSDTFARLLVNWPQTKNTTNSESKEPRVTLGGHADMGALTMLFNVSGGLQILPKGKENVNERWEYVRPRPGCALIDVGDSLMKWTGGVLHSAFHRVVTAPGEQGSVARQSVALLTRPDRSVTMQRIKGSALIPPLKEGEVDDDRSASDWIIWKITKGELRVQTAEEKRVAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBG5</accession>
    <name>A0A8G1RBG5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_517790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518142.1">
        <property type="nucleotide sequence ID" value="XM_025664938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBG5"/>
    <dbReference type="GeneID" id="37168340"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877:SF2">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH60220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="150" mass="16843" checksum="FE75DE82416F4243" modified="2022-01-19" version="1">MSTRIRQATPDDQPIIEAIIQEAFSIYIARIGRKPQPMLDDYTALIKDGVVYVIERDGEIKGTVMLVPQESSLIVDNLAVAQSARGTGLGRKLLEFADESARLAGYRALQLHTNETMVENIAIYTRMGYAETHRADNKGWKRVYMAKNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC08</accession>
    <name>A0A8G1RC08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_465024</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="6">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="6"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521000.1">
        <property type="nucleotide sequence ID" value="XM_025662019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC08"/>
    <dbReference type="GeneID" id="37165421"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.10:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000054">
        <property type="entry name" value="Protein transport protein BOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="809"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="58"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="10">
        <location>
            <begin position="201"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="521"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="677"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="707"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH63078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="830" mass="90424" checksum="2725E9489211E3C4" modified="2022-01-19" version="1">MVASAVRMRAPSAMFLSKGALSLKRPQTVHRFKDIAQSQLPSLSALSRFYASKSFPPHTVISMPALSPTMSAGNIGAWQKKAGDSLQPGDVLVEIETDKAQMDFEFQEEGVLAKVLKETGEKDVSVGSPIAVLVEEGVDVAAFEAFSLADAGGEKAAPAAEESKQESKAAEAAPASEPAPAAVEPETSGEKLQPSLDREPSISPAAKALALEKGVPIKALKGTGRGGQITKEDVEKYKPSASAGPTYEDIPLTSMRKTIASRLQQSVRENPHFYVSTTLSVSKLLKLRQALNASSEGKYKLSVNDFLVKACGAALMKVPTVNSSWHEENGQTVIRQHKTVDVSVAVSTPNGLITPIVKSVEGRGLSSISNQIKDLGKRARDNKLKPEEYQGGTFTISNMGMNPAVERFAAVINPPQAGILAVGTIRKVAVPVETEEGTSVEWDDQIIVTGSFDHRVVDGVVGAEWIKELKKVVENPLELLFNPQRSVGGVYRDEAESTASLVDVDSPHVQAVDPDFLKQDVQTTTQAERIEREEEEREAYEERRAKSKAKAKAKAKAESARSNAHNPVYLGNAVILALTGAGLGYGAYRKHAAGQLSWEVIGWASGAIGAFGAVDYFVSNRRQIAASLASLSRTVDDYSALSKKELIPEKQEKAFERVKNFRSELADYRQHFDRLRKEREEAQSVTNRNELLGRRPHHTATPENPYAQSSLPQSSAFAPSSSRSGLSFGASPADYNRETHALREQSFLASTNTQIDEFLDRGRAVLADLGQQREVLKGTQRRLYSVANTLGVSGDTIRRVERRARQDKWIFWGGVVLFFLFCWAVLHFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC93</accession>
    <name>A0A8G1RC93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_447214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518562.1">
        <property type="nucleotide sequence ID" value="XM_025659673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC93"/>
    <dbReference type="GeneID" id="37163075"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="13"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="269" mass="29277" checksum="4B4A091E063578FF" modified="2022-01-19" version="1">MTTTYPPTNNPAIVLVSGAWHQPSSYTSFTTALRNLGHEVHVPCLPSINGARPPNAGLEEDSVFIRTCVENLVSAGREVLVLLHSYGGQVGTNALSNGLGVTTRRAQGLTGGIVQLVYIAAFALTEGVSMVEVVISHGHGPLMDVAFDFAEDRTCISRDPKNLLVGPSKKSDEETDAYIASLQRWNGKGFDGKLQHVAWRPEEGGIPQIGYIYSTQDMTVPYDYQKEFVQTMREAGCQVRTWELETGHCALFTKCEEVVEIVHGLAIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCM2</accession>
    <name>A0A8G1RCM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor Btf3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_178954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518742.1">
        <property type="nucleotide sequence ID" value="XM_025654338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCM2"/>
    <dbReference type="GeneID" id="37157740"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF3">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="114"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="365"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="447"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="708"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="722" mass="80473" checksum="3F5EFB4EFBDCA818" modified="2022-01-19" version="1">MALPAHAPVAAMNGHASDLNAQVDVICGPLINFKNMDVNPSSSIWRGSVLIVTKPGQSQPRLLLRQAGPIGASHAGNGARAGDSAVTVDGVRLYEDPQKAFWRFSLSFALESYEARWEYAIPGFTYAEGEEAPSSWDFAVPSVNQSMRMMFHSCNGFSVGTDMNAWVGPNLWNDVLRVHAQKPFHVMIGGGDQLYNDGIRVDGPLKEWTSISNPHTRRAHNFDNNLRARCDEYYYANYVRWYSTQPFKGANGRIPQINIWDDHDIIDGFGSYTDHFMRCSVFRGIGGVAFKYYCLFQHHIAPPKSTYTTDAPQTMHAVNGTAGADPRQLENTFVLDEQQEDDSWIIGKRPGPYVEERSRNLYMRLGKRIAFIGVDARTERTRHQVNYPDTYDLIFSRLQSEVSAANGDIKHLVVLLGVPIAYPRLAWLENILSSPIIAPIRLLNKRFGFAGGLFNQFDGQVDLLDDLDDHYTARQHKKERRIFIQRLQDFAKAHSVRVTILGGDVHLAAIGRFYSNPSLRIHSEHDPRYMVNVISSAITNKPPPKAVANLLARRNKLHHMDSHTDETLMDFFDRQPGGQEKSASWNKVTMPSRNYACITEIETPESNGNAATAQDDIASFPIAVDGHSPLHKGEKNAGSTHPAADGFSSSSDMWGGLDVAIRVEINPQDRAAATEGYAFSIPTLAYVPSEADSRPTSRARSLRPRSLRPPSRQSGRRPQSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD21</accession>
    <name>A0A8G1RD21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromatin regulatory protein Sir2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_362184</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520127.1">
        <property type="nucleotide sequence ID" value="XM_025655615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD21"/>
    <dbReference type="GeneID" id="37159017"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="161"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="335"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH62205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="488" mass="53875" checksum="921500734B617BBD" modified="2022-01-19" version="1">MDLVSAPSGDDSSLKDPVVQVEAVDMASAVSKTGTATENTAAAKEEVTQSEYETDSDGSGDEWETQSLYEDAIQVLRDDQLREGVPDACTLEEAVAYRKRLHEVGKAAFVEETLGQDKVTARKLCTAFGILPPAFLDDAPDEAFHPLLAIAISREFSRRPKLPQYNTIDDAVKLLKESKNIVVLTGAGISTSLGIPDFRSKDTGLYSQLAHLGLSDPQEVFDIQVFREDPSIFFSIAKDILPTEKKFSPTHAFIRVLQDKGKLLTNYTQNIDNIEANAGVLPENIVQCHGSFATATCVKCQYKVKGDEIFDEIKQGVIPQCDACRKRIAEDSGIKRKRSSNGVHKNRKDNDGDSTDDDYEIPTPGVMKPDITFFGEDLPDEFGRRLLHHDRDQVDLVIVIGTSLKVAPVAEVPGVLPRTVPQLYISRTPVSHTEFDIDLLGDCDVVVSELCRRAGWELKHEMIPEDEKVEVLPVEGYESRHVFKVVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDZ3</accession>
    <name>A0A8G1RDZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_13159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520846.1">
        <property type="nucleotide sequence ID" value="XM_025653991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDZ3"/>
    <dbReference type="GeneID" id="37157393"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="94" mass="10526" checksum="A63CFE610D626E4A" modified="2022-01-19" version="1">MLSNVFGDLLWQSGQDYRHTSPRYQLRGRTPITVESLARIPAWLIRFGFVQRQVKPVLPFQAIQLSPLNAASFPLPSAGPSILLFLGLLRLLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RE20</accession>
    <name>A0A8G1RE20_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_495447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521448.1">
        <property type="nucleotide sequence ID" value="XM_025663925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RE20"/>
    <dbReference type="GeneID" id="37167327"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF11">
        <property type="entry name" value="O-METHYLTRANSFERASE (AFU_ORTHOLOGUE AFUA_2G17820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="63"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="233"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH63526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="402" mass="45060" checksum="526495299FD7522A" modified="2022-01-19" version="1">MEQLRLQAVCFLLEEVKTSIEELQDKNTDKARVAAHGNVIKLARAIENPNDLILNLFFSPTQLMAVKVGHDVGLFAALVGSNTAVTSKQLAAASDAHPLLIERIMRVLVAMGFAEEQEGGTYLANALSREMTEKASTSVIETLFTDVAPVIQKTPEFLRKSGYQNPENGREGPFQYTYNTSLCTFDWLAENPIIQARFHAYVDGVRSNRPYWFDWFPVQERMLNDCAKNPDEPLLVDIGGGTGRDISAFRDRFPDAIGRLFLEDLPSVIDRIQSVDQVIEPIKYNIYDPQPVHGARVYYLKFLLHEFDDENCKVALRNITAAMKRGYSKLVIDEFVLPDQNAGIFYSMLDMGLMAFRSGMVRTQTQWTTILQSVGLHVNVICFPDGNGPAIIEAELLGEDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RE92</accession>
    <name>A0A8G1RE92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_8942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520742.1">
        <property type="nucleotide sequence ID" value="XM_025665766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RE92"/>
    <dbReference type="GeneID" id="37169168"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="103" mass="11424" checksum="CC9D74E93DA313AB" modified="2022-01-19" version="1">MPQATLTTNQSTACVPRGCDSKVSLNQESAGPRIQLTLSETEDGVDICQLHGLTGSWWNNGTTRTFRERLTRLLRPVMTSAYEAQSRLWCFYESSLILVAGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1REV3</accession>
    <name>A0A8G1REV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_389246</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519942.1">
        <property type="nucleotide sequence ID" value="XM_025656740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1REV3"/>
    <dbReference type="GeneID" id="37160142"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000070">
        <property type="entry name" value="Putative pyridoxal kinase C6F6.11c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="118"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH62020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="367" mass="40315" checksum="825E860126A7BF5F" modified="2022-01-19" version="1">MSADLLVPETRVLAVASHVVYGYVGNKMATAVMQLMGCDVAALNTVHFSNHTGYRQFKGTRATAEEITALYEGLTQSNLLDFDVMLSGYAPSAAAVEAVGAIGMDLQRKAEKNPGSFFWVLDPVMGDQGRLYVNDDVVPAYKKVIRHADLILPNQFEAEVLSGIKITSLATLAEAITALHAIYNIPHVIITSVQIASLSDSPLPNTLTVIGSTTRSDGAPRLFRIDVPALDCYFSGTGDMFAALTVARFREAVFNADATLRNTKSWVSPDDVPATELPLAQSTRKVLASMHCVLEKTLEARDAELRAIVPDEGEKLLSQEDQQKRAHLRESKAAEVRVVRHAQYLREPEVEFQASEWRREDLPAQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RF58</accession>
    <name>A0A8G1RF58_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_495542</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521491.1">
        <property type="nucleotide sequence ID" value="XM_025663938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RF58"/>
    <dbReference type="GeneID" id="37167340"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045122">
        <property type="term" value="P:aflatoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013700">
        <property type="entry name" value="AflR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF31">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08493">
        <property type="entry name" value="AflR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH63569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="364" mass="40425" checksum="603AF6EBB2C331FF" modified="2022-01-19" version="1">MLDLSPPSTTPSLSDDNSNTTSSRKTRNSCDACAKSKLRCGKQHPRCERCVMRNQACTYGLARPKGRPRLSHRSPSISPPCSTSLDLSILSTLYDPELIPDIYLDCSSGTTITSTSTLISPGSPHLEDWQFLDHELNLPFDITTIQPTFTQRPVQPSYQMDLALDSASPLPHVSPASLPGPSNSSEHAQSCTSLILDTLRTLSLPLGSCRRSATVPQCPSLGTLLRLNKEAMDNIKVVVECDCSVEPYFPTLVAEVLTKILRWYHKIILDLEYLDCSIPAVLLYPPVRIGEFELSKHDSGRVVAQVVTNELDKVQTLVETFERRFCYYDEPDDYHEAEVCTAFQAGFRESLKNIRSQAVQRMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RH07</accession>
    <name>A0A8G1RH07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_494865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521082.1">
        <property type="nucleotide sequence ID" value="XM_025663880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RH07"/>
    <dbReference type="GeneID" id="37167282"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="218" mass="23066" checksum="21F9976CF78FCD4A" modified="2022-01-19" version="1">MTLITMAVGARRKRSSPLAGVIVPARQTGSWGSQSEAGTPKLFSLDHHAKYKSTLYQPLKNPTDCVATTGVGFLRGGKRSDRHIPHGRGAARCARFKAVSLDFATGCGVDMLRCSTRCKSNARSPAQANPIGTSFCRPGPASGGQLVSACILPPFSDQNLHSPKAQLACQLTTSLYALISFPNVMVHVVAARCAFSHGVGDDIGSVLVIRCLASWLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VFY7</accession>
    <name>A0A8G1VFY7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_454600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825094">
        <property type="protein sequence ID" value="RAH51754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509676.1">
        <property type="nucleotide sequence ID" value="XM_025661325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VFY7"/>
    <dbReference type="GeneID" id="37164727"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH51754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="172" mass="19025" checksum="BAE50BC9E4D59281" modified="2022-01-19" version="1">MHSYGGLPGCEAIRGLDWASRQRQGQPGGVVHLFFCCSFIVPEGKSLISSFGGDDLPWFQVSDDGLLVTPATPRETFYNDMNEVDAKRAVEALKPHSYQTFHSNITFAAWKHVPSTYLYCLRDEAIPLSVQKTMVEEVAKGIQIQTHRVDASHSPFYTAPDHVAVAIKAATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGM9</accession>
    <name>A0A8G1VGM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_407827</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510368.1">
        <property type="nucleotide sequence ID" value="XM_025657378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGM9"/>
    <dbReference type="GeneID" id="37160780"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF668">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="52"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH52446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="456" mass="49411" checksum="CF600A521355B6AA" modified="2022-01-19" version="1">MRLDGVAPPPDAVEPKSQREKDEDVEDLKAIDGAPEVDAFGDEANAEVKYKTLKWWQCGMFMIAESVSLGVLSLPATMTALGLVPSLILIIGLGILALYTGYVIGQFRERHPYIHNLADAGEILMGTFGRELFGLGQILFSIFIMGSHIVTFTVMMNTITDHGTCSIVFSIVAFIICLVLSLPRTIKNLTYISTASFLSIFSAVMITMIGVGVQYKGGQNISITTETNLYTAFSGVTQIMFAYCAHVAFFGLIAEMEEPKDFPKALCLLQGFEISLYVTAAIVIYYYVGNGVDSPALGSAGPVLKKVAYGMAIPTIIGAGVVNGHVGLKYIYVRIFRKSGRMHKNDWVSVGSWIGIGVTCWVIAWIIGEGIPSFSNLVSLISSLFASWFSFGLPGAYWLHMNYGQWWSSPKKCALTIINMLIFAIGGAMCGLGLYASGKAIHDDSSRSSFSCANNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHM3</accession>
    <name>A0A8G1VHM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_493096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825085">
        <property type="protein sequence ID" value="RAH52372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510294.1">
        <property type="nucleotide sequence ID" value="XM_025663812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHM3"/>
    <dbReference type="GeneID" id="37167214"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="116" mass="13063" checksum="1FD82BBE8E0A9F5F" modified="2022-01-19" version="1">MSGDTNMDISEDMSSCPFPKRVPELGDNGIHDEADYPQTKRLRLDEHLVNTSSSNSGTATPCESSGMEYHHHALQQVHCRGQLPLPYTQATRECTFAIDYMEKKTTTDIGTRWAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHV1</accession>
    <name>A0A8G1VHV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_491919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511716.1">
        <property type="nucleotide sequence ID" value="XM_025663745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHV1"/>
    <dbReference type="GeneID" id="37167147"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="389" mass="44214" checksum="E94B6D1B998D436E" modified="2022-01-19" version="1">MAIFNVVLSASYLYIFGTIFFDIVHFLLHRWSRSRWRILRFLSRCHQYHHLYYPRSLQFNQRYAKPNALIALPLELICQLLGSIIGWILATILNCYIKRLDSKALSIVLVVQTVRSLFVIIINGQDSNHIALDKVPKDHSWAFVGPEYHSLHHIYPDRYMGSMVKLFDWVAGTAYALKNKTVVMTGGSGAFGQAMEKQLLAEGVKSIHKLQFGKDWDNGDFSRVGTILQEADIIILAHGTKGLDAMASNCISSVRLIELFMQQKSAQSQRTKVLPEIWYVGSEAELHPAWGGPEMVRYTASKRAFLPYARALYKSDKVIYRHIVPAAFDSRMGKAIVSADWAARCTMSWLRRGAYYIPVTYTGLACLNFFKFLFGPSADPTWVNKIGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIC6</accession>
    <name>A0A8G1VIC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_452315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512286.1">
        <property type="nucleotide sequence ID" value="XM_025660795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIC6"/>
    <dbReference type="GeneID" id="37164197"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034315551" evidence="1">
        <location>
            <begin position="17"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="208" mass="22861" checksum="E4443106395409F7" modified="2022-01-19" version="1">MYFPLAFATFVFSALALPTGGNNKVLPACDATPRPCSCPAGTFLQNSTSWATWPVPAKEISDITANFFETAWFGTTPTETHGEPYTPGAERVLYGELPNAGVYPMTEELRTFKWLPRNKGYQLTFGLAGVPFYYNTTSGPAGQLGGTWEWVDVHAIGKKETYMLWNIYACFSSAYDFAGFHESAMNNITAILKAEGKMTGEMNGPHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIF8</accession>
    <name>A0A8G1VIF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_493738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825097">
        <property type="protein sequence ID" value="RAH51668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509590.1">
        <property type="nucleotide sequence ID" value="XM_025663843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIF8"/>
    <dbReference type="GeneID" id="37167245"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH51668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="200" mass="22579" checksum="78E3D9744C5CE434" modified="2022-01-19" version="1">MAAINKIAINSPSRQNPSELETAIAGALFDLESNTQDLKATLRPLQFVSAREVEVGHGKKAVIIFVPVPLLQGFHKIQQRLTRELEKKFSDRHVLFVAQRRILPRPKRSASSRSNQKQKRPRSRTLTAVHDAILTDLVYPVEIVGKRTRTKEDGSKTLKVILDEKERGGVDHRLDAYGEVYRRLTGRAVVFEFPQGGADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIP2</accession>
    <name>A0A8G1VIP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_473108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509845.1">
        <property type="nucleotide sequence ID" value="XM_025662602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIP2"/>
    <dbReference type="GeneID" id="37166004"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH51923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="316" mass="35657" checksum="04447EFABC4241D9" modified="2022-01-19" version="1">MSPPTSEASWPAGIPEIRQHTTDLSQEELREEAKGWLLFVREKIQPTSTPEDGLRQRRALIEQWATASQEFREAYHSCSAGYSSAFDYPASVLSQIAPRPNKRFLCLPSVDRQTHPRNYIHLVKFLILLYIHQDEWNGVHPFEEHGAGTAPNYHLPDLLGCGPTTRPITTYDEILPSLYLTPADFHALSMTRQGTVVFDNGPNLTWFVIDAPGLATGRLALVDFSSNGHVRVSTLRRPWNMGQTMALRANSGLDMDLPILDILESTRLNNKFLCSGYGSRDLWIRLINESAPGYLELEAQGREVEFELDKLLVIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJF0</accession>
    <name>A0A8G1VJF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Beta-xylanase</fullName>
            <ecNumber evidence="14">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_470957</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="14"/>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512557.1">
        <property type="nucleotide sequence ID" value="XM_025662436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJF0"/>
    <dbReference type="GeneID" id="37165838"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000094">
        <property type="entry name" value="Endo-1,4-beta-xylanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF76">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11 14 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 14 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034653001" description="Beta-xylanase" evidence="15">
        <location>
            <begin position="20"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="16">
        <location>
            <begin position="55"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH54635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="327" mass="35510" checksum="93B3C54F2D5F64FF" modified="2022-01-19" version="1">MVQIKAAALAMLFASHVLSEPIEPRQASVSIDTKFKAHGKKYLGNIGDQYTLTKNSKTPAIIKADFGALTPENSMKWDATEPSRGQFSFSGSDYLVNFAQSNNKLIRGHTLVWHSQLPSWVQAITDKNTLIEVMKNHITTVMQHYKGKIYAWDVVNEIFNEDGSLRDSVFYKVIGEDYVRIAFETARAADPNAKLYINDYNLDSASYPKLTGMVSHVKKWIEAGIPIDGIGSQTHLSAGGGAGISGALNALAGAGTKEIAVTELDIAGASSTDYVEVVEACLDQPKCIGITVWGVADPDSWRSSSTPLLFDSNYNPKPAYTAIANAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKC8</accession>
    <name>A0A8G1VKC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_460024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514551.1">
        <property type="nucleotide sequence ID" value="XM_025661691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKC8"/>
    <dbReference type="GeneID" id="37165093"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF16">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="288"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH56629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="348" mass="38844" checksum="51ADC25678245736" modified="2022-01-19" version="1">MLSILAWLKGSTNTTGQRVFEGFIIYDSNMLPSIFSDACITALTTTIKCDLQANYNRAVLLDHPAIILGGNMWEEWNETCYKDPTTGKYCNDVISQFTHVTSVDLMPKDKIPYSYYNQRYKYNLETVIKNCDKLFFPDDSSYITKDGDTCTSIALDYSIRDCNQVVVGQELCLPLSCDHTYVLKSNDTCRSIEEANAEIVFDNSTKRIIPLRQVNPWIDTYCSNLQSTSWAYGKVLCLTPQSGLFNATDPVSTSYNPWGTESSGYGSWVVLPPDNATVAAETTKHCGKWHTATTEDSCTQICVQDRITSNLFLQVNPSLQSANCTGLLIPGNAYCTGPMRGWNYTVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKK9</accession>
    <name>A0A8G1VKK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipid transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_489801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513727.1">
        <property type="nucleotide sequence ID" value="XM_025663625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKK9"/>
    <dbReference type="GeneID" id="37167027"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1050.10:FF:000001">
        <property type="entry name" value="Putative Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF25">
        <property type="entry name" value="SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="129" mass="13629" checksum="110A30C84A111D7D" modified="2022-01-19" version="1">MSLKNDAFPSSAAFDAINSTLQADAAERKEAINKAKAVVAFNIKNDKGQEESWYLDLKDKGVVGKGAAPEGGKADVTLSLSDADFSALVSGKANAQRLFMGGKLKIKGNIMKATKMEPVLKKAQGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL03</accession>
    <name>A0A8G1VL03_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Charged multivesicular body protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_37866</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515226.1">
        <property type="nucleotide sequence ID" value="XM_025656307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL03"/>
    <dbReference type="SMR" id="A0A8G1VL03"/>
    <dbReference type="GeneID" id="37159709"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH57304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="216" mass="24151" checksum="8B5240DA8AA9F64C" modified="2022-01-19" version="1">MNRLFGTKNTAPKPTLDGAITNVETRISSIDVKLAALNSELSTYQTKISKMRDGPGKTALRQKALKVLQRRKQYEAQRDQLSQQSWNMEQAGMMQDNLKNVMTTVDAMKTTTKTLKKQYGQIDIDKIERLQDEMADLMDVGNEIQESISRAYDVPEDVDEAELDAELEALGEETMMESSMADSAMPSFLQDEVAPPQFIDEPPEQTKVKEPASGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLH2</accession>
    <name>A0A8G1VLH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial mRNA processing protein PET127</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_448909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515736.1">
        <property type="nucleotide sequence ID" value="XM_025660052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLH2"/>
    <dbReference type="GeneID" id="37163454"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000964">
        <property type="term" value="P:mitochondrial RNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013943">
        <property type="entry name" value="Pet127"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014:SF0">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08634">
        <property type="entry name" value="Pet127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="739" mass="84980" checksum="00E76DE5B52308C3" modified="2022-01-19" version="1">MYRATLRSVSDPLREHVCLSCLARGLEAQPWARRFHTAPRLRSQATETSSTVAIEEQLKALEKNLPDRRTPAHVKKSLRTQNPKSPQNADKKAVRKAAKQEAMKMRKMDPANQAADTETPKEEKKQPEPKDKKDQKARAQQKTAPDSSTSPKPQVSANKQSTKLQLPVPITGKDTGKINADRDSVKALDVETPEVPQLAYGLDRVLFNPGVYHLRDPRSRVYNFDPYLGSIMPVTEFDFEALKEYITSSKDEQLRGLAQKEKKKYIGSSSSMTSVLSHFHYLLSYWREVNIQQVSRGFQERLRTFTRLLRAPSAMFLRYQNGVYAIDADKEHDTANILMNLGKSMEKLLTMPKEEFERYRRSSSNKISAEEEQAVPEAYHYSTYGDFLMRSQLDAYDPRLPGTGMFDLKTRAVASIRMDAKNFEHGLGYEIRKAHGTYESYEREYYDMIRAALLKYSLQVRIGRMDGIFVAFHNIERIFGFQYLSLPELDMALHGQYDTTLGDREFLLSLQLWNKVLNKVTARFPKQSLRFHFETRDSTAGPPYMYIFAEPVTDEEIHAIQTKNQAEIDAYQRRVLDLPGRADEDDDTTTTTNDTEDIPADFESSSPADDLAEDTATTKSETSQDEAETTPSKEIMGFALTVRNIVDGEYVDRPIQFQSPNKWSVDYELNHLDSNKCWKLYNACQERRRKALSGRGEDETDVAANTYIRRLREYAKKGRKYRKEQNKLDEQEKLVVLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLV2</accession>
    <name>A0A8G1VLV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_459869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515047.1">
        <property type="nucleotide sequence ID" value="XM_025661680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLV2"/>
    <dbReference type="GeneID" id="37165082"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="493" mass="55845" checksum="8A556ECF5EDE976A" modified="2022-01-19" version="1">MERPRNIEDLADELISDILSYLLGSDNLSPEPSPTTPQGSSRDSDNGTAHAFGEKSELDRFRLVCRRFKRIGTPRKFTSFVLRFSSDEFRRLEDLLNMQLACHVRYFTYMVRPFYQGSGWSHILDGVDVDNLPVSSIHRRRLDDQKYILDSNLDLRLLRRAIAAFSSLQQVKLLRLQDGADEQLLDHIRERSLGRTTRLDWEPACTRAVTSLSISLLESNCNSVRFVGPQISPEATVRLLQAPSTSLSALGARLASLDVTFHSAAKLSTYMETLSNVFHDFFLAAKNLTTIHLGFPTNAPLDLALEQIFHHVQWKRLRTLSIQGWRLGSEEIIAFIRRHRRQLRNVRLANVYLRPGGRWRDVLSVLHDEMDLLERIDLRGIDYTSHFDANANAHHHADAAGPGAGSSQTPTLAIVVQPTPDMAPHKAFLNMDYSNSSPPGKTRRAFSDATLEQLRGHTSDVLGDNGESVSHDQRLLWEAWVLSSQRSNVHRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLV3</accession>
    <name>A0A8G1VLV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_459349</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516111.1">
        <property type="nucleotide sequence ID" value="XM_025661647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLV3"/>
    <dbReference type="GeneID" id="37165049"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034254013" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="209" mass="22685" checksum="71F58BCFCAB9A822" modified="2022-01-19" version="1">MSLFTFLISVISAIMAPALDKVQQELHFPSSTTGVISLSVYLLGVAIVPLFTAPLSEISSRMIILRATDVLFIVFNTLCGTARTPNQLIGLCFLAGLGGAGAKTTKLYHGFTDYYRNIGAAIYGAGALHEIQCIVGYIMDTYPKYASSAVAAVMFLGLGWGNTLLALIAVVVGIPAPILLRWRYGDGVHMRRMISFWKNYSDLEVSECY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLY6</accession>
    <name>A0A8G1VLY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YagE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_396914</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515993.1">
        <property type="nucleotide sequence ID" value="XM_025657009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLY6"/>
    <dbReference type="GeneID" id="37160411"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="373"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH58071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="662" mass="73250" checksum="0551C140A5CEAE80" modified="2022-01-19" version="1">MTPARGRGPSQRSPHVLVTDSRDQQTTQPRRRRSPATRFITVDNVLQYTSDVPSMQQRHPPQGGVRARPRSRLASAAGGLIGAGGAGSSTGGSSAVSTAASMKRLAAQPRLPPRTTKVSEKLVLLPEAGDELREEEEGEEEDEEMVDEEFVQKIAKDKNLDPDSVRQTLLAQKKLDGDFGVDNEIAPLLAEEELMKRRKVAPEKAKSYAERLPKARRAEKLARVTAYCTAQAYKMSSLASFVKERHGGKTKLYDDCLYTAYHLPLLPGHEGYRLRSSPVLKKPGGKSLLDEEIERNELRDHHEDYMPEAEEHSVFGGRHEHGPHPHESHQAGEEDHAGSGSREQFGQGTAHSQPGPTAGSTASSRLSYNVAEMFVFSYGVVVFWNFTEKQEKDLLADLAFATSSATGSPIPLATMPLQEEDFETEEFHFEYSTEIKRPRVYNDMITLRSGDHMIKLAISHGIAQSTKLCFFEEVMARQMAEAKDVPRRLAMTGNLGMKRDEVFRILGSLFKSRVEVNLSSNMLDVPNFFWESEPTLYPLYIAVREYLEIKPRIQVLNERCRVFLDLAEILSDSIADNRTSHQTWIIIVLIIISILVTTSEVFLRFGLLSARENGASSTITTILSRALGHTSPAPVCSCPPVPAVPGVPAGMGGALNTTGLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLY8</accession>
    <name>A0A8G1VLY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_487037</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516216.1">
        <property type="nucleotide sequence ID" value="XM_025663427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLY8"/>
    <dbReference type="GeneID" id="37166829"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH58294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="290" mass="31606" checksum="98AD2054609C5B67" modified="2022-01-19" version="1">MFSRAVRPAVRAGSIAVSRTAPPNAANFATLREIEGRLKSIKNIEKITNTMKVIASTRLTRAQKAMEDSRTYGQTSNTVFENAETKPLEDKKTLLVVASSDKGLCGGIHSGLSKATRRMLQQHPDADIVVLGEKAKAQLSRTNPNAIVLSFANVCKDIPTFNDAQSIADQISQLPTDYASIKIIYNQFINAQSYEAGTVEAYSEEAITQSPNLSAFETDDQTLAHLREYALANNLFWAMAEGHACEISNASKNAGEMINKFQILYNRQRQAAITGELVEIITGATASADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM78</accession>
    <name>A0A8G1VM78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multiple RNA-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_487089</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM MRD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516278.1">
        <property type="nucleotide sequence ID" value="XM_025663431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VM78"/>
    <dbReference type="GeneID" id="37166833"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12565">
        <property type="entry name" value="RRM1_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12568">
        <property type="entry name" value="RRM3_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12570">
        <property type="entry name" value="RRM5_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000247">
        <property type="entry name" value="Multiple RNA-binding domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000452">
        <property type="entry name" value="Multiple RNA-binding domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000459">
        <property type="entry name" value="Multiple RNA-binding domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000839">
        <property type="entry name" value="Multiple RNA-binding domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034482">
        <property type="entry name" value="Mrd1_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="301"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="484"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="597"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="702"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="80"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="774"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH58356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="825" mass="91306" checksum="B132C4ABDE825DA7" modified="2022-01-19" version="1">MESTRVFVSGLPPTLSDDQLRKHFATRFQVTDAHVLPKRRIGFVGFKSHEAAQQAVSYFNKTYMKMSKISVDIAKPIDAEPTRKAGKHDKISAGDAADTSLKRKRDGESAPQDARLQEYLSVMQHSSKTKTWANDDVPKPPELDSPAEQPAEVEEQPQELTYAQRKKAKLGDDHDRSQEMHTADREAHGSPEPMVVDHSGEGNAEAPAEQDDTVAETEAPAVSDADWLRSKTSRLLGLLDEEEQADFDAAAQQKEPAAPEEAEDPGADSRDAQIVAPAATEAKTVQEPQVDTNIDGIRLSARLFVRNLAYDTSESDLEPLFAPFGRIEEIHVAFDTRVNTSKGFAYIQYLDADAAVEAYKNLDGKHFQGRLMHILPAAAKKTYKIDDAELAKLPLKKQKQIKKKMDASSSTFSWNSLYMNTDAVMSSVAERLGVSKADLLDPTSSDAAVKQAHAETHVIQETKAYFSANGVNIEAFKQRERGNTAILVKNFSYGVKTDELRKMFEPFGQITRLLMPPSGTIAIVEFSRPDEAQKAFKGLAYRKLGDSILFLEKAPKDLFDAAAVPQKATIETKAVSQGFSTADTFAADEVDDLTPTTTLFVKNLNFATTTQSFVDLFRPLDGFVSAKIKTKPDPKHPGQTLSMGFGFVEFRSKAQAQSALAAMNGYKLDQHELVVRVSHRGMDAAEERRREDTAKKVAARRTKIIIKNLPFQATKKDVRSLFGAYGQLRSVRVPKKFDRSARGFGFADFVSAREAENAMDALKNTHLLGRKLVLEFANEEAIDAEEEIKQIEKKVGEQMDRVKLQKLAGPGRKKFTVGAQDGEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMB1</accession>
    <name>A0A8G1VMB1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">pectin lyase</fullName>
            <ecNumber evidence="12">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_514051</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="12"/>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515274.1">
        <property type="nucleotide sequence ID" value="XM_025664734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMB1"/>
    <dbReference type="GeneID" id="37168136"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000003">
        <property type="entry name" value="Pectin lyase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF16">
        <property type="entry name" value="PECTIN LYASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034455290" description="pectin lyase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="15">
        <location>
            <begin position="83"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH57352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="373" mass="39336" checksum="E695FE4FE76594A4" modified="2022-01-19" version="1">MKVPFLHLLCLNAALASASVVKGAAQGFAAGVTGGGDTAPSYPKTNEELVSLLESDEPQVIVLTKTFDFIGTEGTTTEDGCAPWGTGKACQLAINSNGWCGKNPAVTVNYDKAAKNGIHIKSNKTLVGEGDKGVLSGKGLYFEGGVSNIIVQNIKITDLNPGFVWGGDAFTFFGADLIWIDHCETSLIGRQHYVTGFHPNTRMTWSNNFLNGKTTHSAGCDDHHYWTLELVGKGDEITFQNNYVYHTTGRGPALSGTTLFHAVNSVWSSIPGHAIEGGEKGRGIFEGCFFEDVVEVAPAKPENQLFSASEANAASCKSALGRACQPNGYSKSGAFSSSETGFFSDFSGLTIAPAGSATDARGYVPKNCGIGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMC2</accession>
    <name>A0A8G1VMC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_280003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516621.1">
        <property type="nucleotide sequence ID" value="XM_025655186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMC2"/>
    <dbReference type="GeneID" id="37158588"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="178" mass="20615" checksum="E53928B72B0E38DE" modified="2022-01-19" version="1">MYAYQWAGVSSCLLVPMSRSSSLCPKDHCNERMYQDLEQITICFLLSLINCIFLHPFPNIIYFTQFHLNLCHGSANFLFLSRILALVLTKRCRRTWAMGPDLIYGVSPLLTTWRARPLETKRVWSNLDFFLCLTLSVVRWTCVGGGGALVWKRWPRARVESKTLFHPSRCVLVMPHVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMC8</accession>
    <name>A0A8G1VMC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ras small monomeric GTPase rasa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_458867</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516636.1">
        <property type="nucleotide sequence ID" value="XM_025661610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMC8"/>
    <dbReference type="GeneID" id="37165012"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04138">
        <property type="entry name" value="H_N_K_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH58714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="212" mass="23801" checksum="F3721E49B0B501B4" modified="2022-01-19" version="1">MASKFLREYKLVVVGGGGVGKSCLTIQLIQSHFVDEYDPTIEDSYRKQCVIDEEVALLDVLDTAGQEEYSAMREQYMRTGEGFLLVYSITSRQSFEEIMTFQQQILRVKDKDYFPIIVVGNKCDLEKERAVSEEEGEALARQFGCKFIETSAKSRINVENAFYDLVREIRRFNKEMSSYPSGAGGGSRAPEGKMDVSEPGDDAGCCGKCIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN94</accession>
    <name>A0A8G1VN94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="10">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_489275</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514405.1">
        <property type="nucleotide sequence ID" value="XM_025663590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN94"/>
    <dbReference type="GeneID" id="37166992"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000019">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH56483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="78" mass="8886" checksum="EABE56FD1F2D988A" modified="2022-01-19" version="1">MPQAQPELKKYMEKRVFCQLNGNRKVIGILRGYDVFMNIVLDEAFEEKQGGEKVAIGMIVIRGNSVVMLEALERISDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNB4</accession>
    <name>A0A8G1VNB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspergillopepsin-1</fullName>
            <ecNumber evidence="4">3.4.23.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Aspergillopepsin I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Aspergillopeptidase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_448623</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity. Generally favors hydrophobic residues in P1 and P1', but also accepts Lys in P1, which leads to activation of trypsinogen. Does not clot milk.</text>
            <dbReference type="EC" id="3.4.23.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.18" evidence="4"/>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516532.1">
        <property type="nucleotide sequence ID" value="XM_025659982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNB4"/>
    <dbReference type="GeneID" id="37163384"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
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    </dbReference>
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        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ASPARTIC ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 18" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034208882" description="Aspergillopepsin-1" evidence="16">
        <location>
            <begin position="20"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="17">
        <location>
            <begin position="106"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000391"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013210"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020252"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH58610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="424" mass="44726" checksum="2E2AE15E3D32BD19" modified="2022-01-19" version="1">MQLLQSLVVAICFSYGVLSLPHGPSNQHKARSFKVERARRGTGALRGPAALRKAYRKYGIAPSSFNVDLADFKPITTSHAAAGSEVSEPDQTGAVSATSVESDAEFVSPVLIGGQKVVMTFDTGSSDFWVLDTNLNETLTGHTEYNPSNSSTFKKMDGYTFDVSYGDDSYASGPVGTDTVNIGGAVVDEQAFGVPNKVSQSFIDDTNSNGLVGLGFSSINTIKPEAQKTFFANVASSLDEPVMTASLKSDGVGEYEFGTIDKNKYQGNIANVSVDSSNGYWQFSTPKFSVADGELKDIGSVNTSIADTGTSLMLLDDDVVTAYYAQVPNSVYVGSAGGYIYPCNTTLPSFSLVLGESSLATIPGNLINFSKVGTNTTTGQALCFGGIQSNGKTSLQILGDTFLKAFFVVFDMRGPSLGVASPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP48</accession>
    <name>A0A8G1VP48_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_436242</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518526.1">
        <property type="nucleotide sequence ID" value="XM_025658567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP48"/>
    <dbReference type="GeneID" id="37161969"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000005">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000015">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="319"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH60604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="720" mass="80012" checksum="5C6AFCC6CAF1F138" modified="2022-01-19" version="1">MDRRTPYTLSVLAPSVDGVEDSRSQIRAKLKEFVLEFQLDNAFIYRDQLRQNVLVKQYYCDIDIAHLISYNEELAHKLTTEPADLIPLFESALQDCTRRIVYPSQRDIQLPTHQLLLHSSATHISIRDLNATNISHLVRIPGIVIGASTISSKATVMHVRCKNCGHHEDLQVDGGFSGVQLPRRCGRQQQPGDPQSEPCPLDPYVVSHEKCQFVDQQVLKLQEAPDQVPVGELPRHVLISADRYLANRVVPGSRCTVMGIFSIYQSSKGGKKDGAVAIRNPYLRAVGISSDLDHTAKGSAIFSEEEEQEFLELSRRPDLYEALAKSIAPSIYGNLDIKKAIVCLLMGGSKKLLPDGMKLRGDINVLLLGDPGTAKSQLLKFTEKVSPIAIYTSGKGSSAAGLTASVQRDHATREFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTILNSRTSVLAAANPIFGRYDDLKTPGENIDFQTTILSRFDMIFIVRDDHERSRDESIARHVMGVHMGGRGVEEQVEAEIPLDKMKRYISYCRTRCAPRLSDEAAEKLSSHFVTIRKQVHRAELDANTRSSIPITVRQLEAIVRITESLAKLSLSPVATEAHVDEAIRLFLASTMDAVTQGEGQGSKEMMEEASKIEDELKRRLPIGWSTSLATLRREFVDGRGYTEQALNRALVVMQRRETVQIRSGGSQVYRHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPK9</accession>
    <name>A0A8G1VPK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FH2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_284587</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515755.1">
        <property type="nucleotide sequence ID" value="XM_025655231.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37158633"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.150:FF:000003">
        <property type="entry name" value="Cytokinesis protein SepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2220:FF:000006">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000291">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.30.50:FF:000001">
        <property type="entry name" value="Cytokinesis sepA protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="5">
        <location>
            <begin position="286"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="6">
        <location>
            <begin position="1137"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="4">
        <location>
            <begin position="1578"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="986"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1278"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1593"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1005"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1022"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1291"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1605"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1629"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1649"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1675"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1703"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1731"/>
            <end position="1745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH57833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1811" mass="200307" checksum="C2347AAD9D0AFE79" modified="2022-01-19" version="1">MPTTTSAPDKSRQTSAGKSFFGRKLHKEKPVDDRHDAHTGFETLAPPGSAPGSRSSRHSKRSSVQSMDFSNEIDPAALSMTAGVITSIPYESLPADTKSPIPIDYLSKAETSPRKEPSPNHLAKGGSDFHQYPAWNPATIRDNNVYSHPTGPRPPPHASNVTMAGSSSGDKGARYQQWGRPGSSAANTGFSHNSSSTVDSSSHSRISFDQASVHSSLSSNTRDTRGSSYFSSDGSSRTLTTSHSADRNTYSSNGTSSRLSNAQAAWQSAQPAQPAKLPANPEQYLTRPRDDRIVDQLFLELMQKRGWQNLPEQAKRQMLAYPASKKWTLVHQDRLTEIQGEQKRRQNARQTHGHDGPSGILERADEEGSPEWYVKKVMDDSITSKQLASLSVSLRTQPISWVKAFVEAQGQIALTNVLAKINRRKASGPVPAPPTGDKDLDREYDIVKCLKALMNNKYGADDALAHQQVIVALVSSLLSPRLNTRKLVSEVLTFLCHWAEGQGHQKVLQAMDHVKNHHGETGRFDAWMRIVEVTIDGRGKMGSLVGASEEYRSGGIGMENLLMEYAVSTMLLINMLVDAPENDLQLRCHIRAQFTSCGIKRLMTKMEGFQYEVIDKQIERFRENEAIDYEDLLQRESSSVKDSIEGEVKDMNDPLQITDAIASRITGTRAHDYFLSAMQHMLLIRENSGEDGLRMYQLVDAMLSYVAMDRRLPDLDLRQGLTFTVQSLLDKLHTDSEARQAYDESLEARQIAEAALAERDEMKAQIELGADGLVKKLQKQIEEQTGIIELQRRREESIRAELADVQRLRAQELQRNELETRELYLMLRDAQDIAASNAKKNNLAEVDPSHMRGIMDREKLLERLEMQLERTKTQFKLEGKVWGQHVTSDRLRELREQMDGDVEPQDGFQDQAHHVAGLGSVQRKRSHLPGMEKDTVEGQQQEGQVDENGEIIYERARLVDLHRPRLNPKQANGLLGEIASRVPKIDADDNEATPVVPEATAPVTDEPKVESEIEKPEAKGAPAPPPPPPPPPPPPPGAVGIPPPPPPPPPPPPGGAVGIPPPPPPPPPPPPGGKVGIPPPPPPPPPPGGAGFPPPPPPPPGASFGAPPPPPPPGAGFGGWRANYMASQALPQHKTALMPSIRPKKKLKALHWEKVDAPQVTVWAAHAPTAQEKEEKYVELAKKGVLDEVERLFMAKETKIFGGNAAAKQRKDKKQLISNELSKNFQIAMAKFSQFPADDVVRMIIHCDTDILDNQVVMEFLQRDEMCTIPENISKSMAPYSRDWTGPDAASAEREQDPNELTREDQIYLYTAYELNHYWKARMRALALTRSFEVDYEHISAKLQQVVKVSESLRDSVSLMNVLGLILDIGNFMNDANKQAQGFKLSSLARLGMVKDDKNETTFADLVERIVRNQYPEWEGFVDEINGVVAIQKLNVDQLRTDAKKYIDNIKNVQASLDAGNLSDPKKFHPQDRVSQIVQRSMKDARRKAEQMQLYLDEMIKSYDDIMVFYGEDNSDEGARRDFFAKLASFLLEWKKSKEKNISLEESRRRTEASLARKRNINAGLANGAASASDAPPSPATSGAMDSLLEKLRAAAPQARDQRDRRRRARLKERHQVRVASGQKMPDVAGAEAPEGGNEAENDGSNSKAGNDNDSEANAAASGLLSPPLLEAETSESKKDPQHVSESEDVADRAASMLQGLRDNMDGDRMRRRRETAEEERRKRRLRRRNGGSTSNNSAEGSAATSVPEPISPPRTDLEPDDATSPRSGDDPLPQPPLTPAIVVSPTADQQLRSPGDDELMEGSPSSRSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPW0</accession>
    <name>A0A8G1VPW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_295816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516040.1">
        <property type="nucleotide sequence ID" value="XM_025655301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPW0"/>
    <dbReference type="GeneID" id="37158703"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="159" mass="17132" checksum="07D40EC71631A0FA" modified="2022-01-19" version="1">MDTTYYSVLLLTTDTTKSPSTSTIRTIRYPCCFPQPHFQGALSTGSGQVPLFLTSPKSDPCPHSQAGDRIDLLCGDRIPIPAPPSTAITLQSSVSGWGSLTSVLILNETYHSGQFPVRSWFGSDLKPLVIRNSCAPPVQTLSSHSSSLGAGRKTWSQTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ53</accession>
    <name>A0A8G1VQ53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_226602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518319.1">
        <property type="nucleotide sequence ID" value="XM_025654747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ53"/>
    <dbReference type="GeneID" id="37158149"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="217" mass="23686" checksum="927FBA1F72273B95" modified="2022-01-19" version="1">MTLCRPQKCLAFALVDFYSFLFGREFFPLQLLTIVLPLNCTMKGPYIWLVCRSAELCLSQTQELLFSVSGRVPLSLPSSQSSPPPNALLSAHGGEDQPSAPATLSPSTHSLLFGLGGPIALSVIVQAGLDNCSSACTQNMQNFPKPFRPSSFKSVIVTLGQTLDRNIRTDCLSISQWKTLISSILLCYIQIWLPLMIRVSPPAENSGKIIFPRVLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ63</accession>
    <name>A0A8G1VQ63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_445126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519621.1">
        <property type="nucleotide sequence ID" value="XM_025659181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ63"/>
    <dbReference type="GeneID" id="37162583"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="72" mass="7871" checksum="62E2CB3E2F127C4F" modified="2022-01-19" version="1">MAHGKKNRLWAKTLGPLELQWRFAAGRCAEQVQCRSSPGVVMMIDAVFAHFLLLCAGLLPSQLWGGGVKVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQA5</accession>
    <name>A0A8G1VQA5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_416068</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518469.1">
        <property type="nucleotide sequence ID" value="XM_025657718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQA5"/>
    <dbReference type="GeneID" id="37161120"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH60547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="531" mass="61356" checksum="A7F41DC2AE537D5A" modified="2022-01-19" version="1">MDISRRLPSLEWQDIVDIGLTIGMYVCLLAPFMVIFIVGLVLYRLYLSPLAKFPGPRLAAATGLYEFYYDVIRDGQFVWHIERLHQKYGPVVRIKPWEIHVNDPDNYNTLYAGVTRKRNKDSWFTFVGWPTSIFSTNGHALHRARRSVLAQFFKRQAILDVEPLIQNNIRALCSHFRHAQRGNYSLELHTAFLCFTSDTISQYAFGKQNGFRTLDQAELSTASKTKMVCTFELVQTARHFPWICKLAHVFPWPAKLLNADFVESLTQEREVQNMVRKAIQERGKGSSEKPMPVYPAILENDRVPEDEKRFSRLADDANLLVLTGTDAPGRALVMTLYFLLRDPEVHGKLRAELCAFWPDASMDLELIALEKLPYFTAVLKEGLRLGPIVSTRLPRVAPDEILQFHGYEIPRGVPVSMTAFFIHRDPKIFPDPLRFIPERWLLEPEDLQKLERYLVPFSRGTLACLGPKPTLTEGSMTWAWLYLVLGTLLRRFEMRLHNTTEENIEVTRDKFLGQTERGKNRVQIKVVREYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQI6</accession>
    <name>A0A8G1VQI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_364865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH60787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="217" mass="25924" checksum="BC594BD0169055C1" modified="2022-01-19" version="1">MVYYYTSKVVDPSAFIYVGKDKFENEDLITHGLEKDVWYRCFHVDNLSSAHVYLRLREGETWDNIPQQLLEDCAQLTKANSIEAGNKKDNITVIYTPWSNLMKDGSMATGQVSFHNPKMVRKVLVRQRENPIVNRLNKTRIEKFPDLKAEKDEYLKKKQKEERKVREEQRSREKQERREREQLKWQKDHAYDDLMSEENVQASNNQDRDPDFLDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQV7</accession>
    <name>A0A8G1VQV7_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Cupin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_485000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025663287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQV7"/>
    <dbReference type="GeneID" id="37166689"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR047121">
        <property type="entry name" value="YjiB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448">
        <property type="entry name" value="BLR7373 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448:SF3">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="66"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="180" mass="20000" checksum="92B65D4A73DB5F03" modified="2022-01-19" version="1">MSFSPPSEISVTSRQIPKWGGIPNTSIQSKPLMIYHKAFNASANDLAAHLEEIGEVRPQWVYSMYSQTHFHSTTHEVLGVVSGRARLCFGGEANPERFEPTVEKGDLIIVPAGVGHRLLEELGSDQGDPFQMVGAYPPQKQWDMCYGDSREEDKVSRNIHALSWFHSDPLCGQDGPVLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQZ2</accession>
    <name>A0A8G1VQZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_192730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025654443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQZ2"/>
    <dbReference type="GeneID" id="37157845"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="134" mass="14645" checksum="DBFCAEE3417C018A" modified="2022-01-19" version="1">MISSRLFVISITDIHPMTQSRSCFTFALSILFLFSVSSGSSVVPSEFIDLSEPVLACLLFSFIYLYGIPASFSCLPPSVFALPSTPSFRFSFFILCLLSPAGYPIISWCPSSAILCVTIYHAFFHMGLTCIGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR42</accession>
    <name>A0A8G1VR42_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_446587</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519354.1">
        <property type="nucleotide sequence ID" value="XM_025659538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR42"/>
    <dbReference type="GeneID" id="37162940"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000187">
        <property type="entry name" value="Probable FAD synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="94"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH61432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="297" mass="32944" checksum="6CCC3626F33B5F8D" modified="2022-01-19" version="1">MTDSIPPTPNGLPTTTSTPPPTTSTTDTTTTTNTFPPSTTPSLSSIITHCHTKIHTFLSESHPADSLLAKVQHQTRTSLNVISTALHRYPLNELSLSYNGGKDCLVLLVLFLASLHPHPAPEDGGLTSIPAIYALPPDPFPDVEEFVQWSARAYHLNVLKYTTDPPRSTIKSTFEDYLFVNPGVKAIFVGTRRTDPHGAKLTHFDRTDSGWPDFVRVHPVIDWHYAEIWAFIRHLGLRYCGLYDRGYTSLGGTADTHPNPKLRVEVDGEDAGEGVEEGRYKPAYELTEDLEERLGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSA0</accession>
    <name>A0A8G1VSA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_473407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520629.1">
        <property type="nucleotide sequence ID" value="XM_025662623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSA0"/>
    <dbReference type="GeneID" id="37166025"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031957">
        <property type="term" value="F:very long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF267">
        <property type="entry name" value="MALONATE--COA LIGASE ACSF3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="563"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH62707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="925" mass="104120" checksum="EA8887ABF7502A1A" modified="2022-01-19" version="1">MASGILTYLEQAAEYSPSKGFVFYSVGKDQPETILYPEFWRLVKRNAQTLVEQKIAVPDRILLVHFDTHKENIIWFWSAIAAGAIPAVSTPLAVDPVARERHLTHLQRLLERPNVLTSIKHTDDLKIIDESQKFFIEDLASNADQSADYEPASPSSDLALLLLTSGSTGNAKAVMLHHSQIFAAIDAKWKALASTPENIFLNWIGFDHVACFMEMHMHALSRGCHQIHLPAVTVLENPLLYLEKMAEYSVTNAFAPNFLVALVGKAIEAQQERDPRSLDLDLSHLRMVLSGGEANLASTSILFNRKLVEMGAAKNVLHPSFGMTETCAGIHYHYSFPELEQKAKLQFCSVGQTTPTLQMRITDEHGETVRSGENGNLELHGPMVFKGYYNDDKNTKAAFTEDGWFKTGDTGYIDNRDNLVLSGRSKDSIIINGINFYSHELENAIDSAGLEGLVPSYTVVVSSWLDNADSEDIIVLYLSSQKGTEDDRIFLETLNSISRITTLYCSKQPVDIIPLPVELLPKNSLGKLPRTKLKSQYEEGRFNTYRDLAARRASAYRARSKRAPQNNMEETLAGIFADEFDLDVSEVGVDDSLYDMGVNSVRLIRYKRIVETRLGLSEEIPMITILQNPTIEALAVMLQDLQKGPKPYNPIVQLQDGPSKAPPIFFFHPGMGEVLVFLNFSKYFADRKVYAFRAPGFNPGEKMFTTIDEMTDTYLKSIRELQPEGPYIFIGYSYGAMIAFETAKKVEASGDRVGFLGSLNLPPHIKKHIREMDYAESLLHLVYFLGFITEEDAHRMSPDMHKLPQSEVLPAIMKVSDKERVQELAMDEGKIRDWAMLSSKLQELAHTYDPSGTVQSMDVFYAIPLLSVGRDKDVWLKQHLMRWKEHSKSVRFHDVPGSHHTMMAEENVFALHKILRAALNERGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSB4</accession>
    <name>A0A8G1VSB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="5 15">3.2.1.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_447194</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Endo-1,5-alpha-L-arabinanase involved in degradation of pectin. Its preferred substrate is linear 1,5-alpha-L-arabinan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Endohydrolysis of (1-&gt;5)-alpha-arabinofuranosidic linkages in (1-&gt;5)-arabinans.</text>
            <dbReference type="EC" id="3.2.1.99"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="5 15"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518545.1">
        <property type="nucleotide sequence ID" value="XM_025659668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSB4"/>
    <dbReference type="SMR" id="A0A8G1VSB4"/>
    <dbReference type="GeneID" id="37163070"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18831">
        <property type="entry name" value="GH43_AnAbnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF7">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9 15 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 18" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034652906" description="Arabinan endo-1,5-alpha-L-arabinosidase" evidence="18">
        <location>
            <begin position="16"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="17">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR026534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH60623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="318" mass="33879" checksum="46FA837555994665" modified="2022-01-19" version="1">MLSFVLLLCVALVNAYSDPGACSGTCWAHDPNVIRRVSDGTYFRFSTGGGIHISSASAITGPWTDLGYALPGGSIVSVGNASNLWAPDVHYVDGTYYMYYASSTLGSRSSTIGVATSTTLEADSWTDHGEIGVTSSSSTPYNAIDPNWITIGSTGYLQFGSYWQGLYQVEMTDSLTASSSSPTNLAYNASGNHAIEASYLYEYGGYYYLTFSSGTAQGYTTSLPAQGDEYRIVVCRSKTGTGNFVDKDGVSCLNSGGTTVLASHDYVYGPGGQGIINTTAHGIVVYYHYANKNIGLAVDDYQFGWNTLTWTDGWPVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VUX4</accession>
    <name>A0A8G1VUX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="11">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_411127</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 54 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="11"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521215.1">
        <property type="nucleotide sequence ID" value="XM_025657512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VUX4"/>
    <dbReference type="GeneID" id="37160914"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23399">
        <property type="entry name" value="beta-trefoil_ABD_ABFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000131">
        <property type="entry name" value="Probable alpha-L-arabinofuranosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000059">
        <property type="entry name" value="Probable alpha-L-arabinofuranosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015289">
        <property type="entry name" value="A-L-arabinofuranosidase_B_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038964">
        <property type="entry name" value="ABFB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007934">
        <property type="entry name" value="AbfB_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036195">
        <property type="entry name" value="AbfB_ABD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447:SF2">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05270">
        <property type="entry name" value="AbfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09206">
        <property type="entry name" value="ArabFuran-catal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110221">
        <property type="entry name" value="AbfB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034670775" description="Alpha-L-arabinofuranosidase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase B catalytic" evidence="13">
        <location>
            <begin position="20"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase B arabinose-binding" evidence="12">
        <location>
            <begin position="352"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="81"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="176"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="401"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH63293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="499" mass="52571" checksum="ACCA59CE0284A1E2" modified="2022-01-19" version="1">MFSRRNLLALGLAATVSAGPCDIYEAGDTPCVAAHSTTRALYSSFSGALYQLQRGSDDTTTTISPLTAGGVADASAQDTFCANTTCLITIIYDQSGNGNHLTQAPPGGFDGPDTDGYDNLASAIGAPVTLNGQKAYGVFMSPGTGYRNNEATGTATGDEAEGMYAVLDGTHYNDACCFDYGNAETSSTDTGAGHMEAIYLGTSTTWGYGAGDGPWIMVDMENNLFSGADEGYNSGDPSISYRFVTAAVKGGADKWAIRGANAASGSLSTYYSGARPDYSGYNPMSKEGAIILGIGGDNSNGAQGTFYEGVMTSGYPSDDTENSVQENIVAAKYVVGSLVSGPSFTSGEVVSLRVTTPGYTTRYIAHTDTTVNTQVVDDDSSTTLKEEASWTVVTGLANSQCFSFESVDTPGSYIRHYNFELLLNANDGTKQFHEDATFCPQAALNGEGTSLRSWSYPTRYFRHYENVLYAASNGGVQTFDSKTSFNNDVSFEIETAFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQ67</accession>
    <name>A0A8G1QQ67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="20">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BO85DRAFT_524615</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 20">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Mitochondrion inner membrane</location>
            <topology evidence="1 20">Peripheral membrane protein</topology>
            <orientation evidence="1 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="20"/>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510148.1">
        <property type="nucleotide sequence ID" value="XM_025665427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQ67"/>
    <dbReference type="GeneID" id="37168829"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:001062">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 18 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <keyword evidence="5 20" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="22">
        <location>
            <begin position="61"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="23">
        <location>
            <begin position="511"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="583"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="66"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="455"/>
            <end position="456"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="19">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RAH52226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="646" mass="70689" checksum="1DA3DD98DB33DA02" modified="2022-01-19" version="1">MSSLGMRSLAPAAKISRTLGQRRLFSSSRPAARIFGNGPLRAKEAEGFIAQKYPIIDHEYDAVVVGAGGAGLRAAFGLAEAGFNTACVSKLFPTRSHTVAAQGGINAALGNMHEDDWRWHMYDTVKGSDWLGDQDAIHYMTREAPASVRELEGYGCPFSRTEDGRIYQRAFGGQSKEFGKGGQAYRCCAAADRTGHALLHTLYGQSLRHNTNYFIEYFALDLLMEDGECRGIIAYNQEDGTLHRFKAHHTVLATGGYGRAYFSCTSAHTCTGDGMAMVARAGLPNQDLEFVQFHPTGIYGAGCLITEGSRGEGGYLLNSEGERFMERYAPTAKDLASRDVVSRSMTLEIREGRGVGPEKDHIYLQLSHLPAKLLHERLPGISETASIFAGVDVTKQPIPVLPTVHYNMGGIPTKYTGEVLTQDENGNDQVVPGLYACGEAACVSVHGANRLGANSLLDLVVFGRAVSHRVRDIATPGKPHKELSSDAGAQSIADLDFVRTAEGPKSTNDIRSAMQKAMQSDVSVFRTQESLDEGVEKVTAIDQTFDQVGTKDRSMIWNSDLVETLELRNLLTCASQTAIAAANRKESRGAHAREDYPDRDDENWMKHTLTWQKKPHGEVKLGYRAVEHNTLDESECKSVPPFKRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS35</accession>
    <name>A0A8G1QS35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II aldolase/adducin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_453373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511198.1">
        <property type="nucleotide sequence ID" value="XM_025661038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QS35"/>
    <dbReference type="GeneID" id="37164440"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF40">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G09800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="71"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="308" mass="33748" checksum="2E670DD88656F854" modified="2022-01-19" version="1">MFATITETATNPVPVVVAADNNSTTSKAHIEDAANDREFQSVARGNRAGTLKLRGIPTFSDPVAKRQWMKEHMAAAFRFFGKKGYGEGVSGHISMRDPILKDHFWMNPFAKHFSTIKASDLVLVDAEGYVTEGGAQLPINEAGFMIHSEIHKARPDVIAAAHTHSIHGKTWSAFGKPIEMLTQDACNLYGKVSVYEDHGGIALAQEEGEQIARALGKDNIACILQNHGLLTVGRTVDEAAFLYFSLDNACHTQLLAEAAAANGVPKRIISNEVAKYTADVAQNHHNFYTEFQPEYELIVEETNGRVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSG2</accession>
    <name>A0A8G1QSG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_442859</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="314"/>
            <end position="508"/>
        </location>
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            <begin position="428"/>
            <end position="485"/>
        </location>
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            <begin position="1"/>
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        </location>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
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            <dbReference type="EMBL" id="RAH52803.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="711" mass="76940" checksum="4F26B6592722A573" modified="2022-01-19" version="1">MPVQTSSPSAPDSFPSFMSVFGRSPEFPDSKDRTSLVKPLRVPTNVTVNTSRRPLPFQHRESISSMTSGSTDSSPTTTISTFDPPSAVDTSPSSSPESPSSMPLSYPTFMPVAHKAECQTHSAAPITDLKPSTDNQNVARPDSPGRRARNLKNLSLRMPLPSQGSRPPIATASVVETSSQHHLSAPPSPIHVPPKGMRRKPANLTIRTPGFDRSFSSNGNDVPPTPHALRHTESSPSLTSVFSPSFGPKGGMQLPRPMTHHGARRPSGASESNLSPLQTVPDEGSGVLHELEEEDDHLDSRESTRRNERGYPNGPIQIYDSGVFLYLEPTAQEASQFDVVVNVAKEVANPFTATAGSTGTVVSTLRNGSASTKRLSTGEPWTAMSDASFKSAFEFPPNDDSSPATPQKDSSGPEYVHVGWDHNSEILDDLFPLCELIDSRISDGKKVLIHCQLGASRSASLVIAYGLYKNRQLDFNSVYELVKERSRWVSPNMSLIYQLTDFRSRLLRGKLSKAAPEEWFVGGARRCSEPQPPQTARTDVSEASTPGFPSGSSDAEPASSNGLSQSSMSSLSVSSNQTTPLSIENLGFSQSLSHKRSLSPRPLPFRQATYHLGPTGKTLQPEYTAPSWRPEAGPCSLAKTDVFVQDMPDGMNSLFSPRTTGFLAPPLSRSIADCLEDDGPHGLRFGSRVADPRSPPPGNERLIMRNIDEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSJ9</accession>
    <name>A0A8G1QSJ9_9EURO</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
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                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RAH52047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8G1QSQ9_9EURO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">BO85DRAFT_443282</name>
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        <lineage>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="RAH52231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
            <begin position="51"/>
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        </location>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
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        <location>
            <begin position="313"/>
            <end position="452"/>
        </location>
    </feature>
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        <location>
            <begin position="109"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
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        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
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        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="452" mass="50012" checksum="5A2F202795F0DB40" modified="2022-01-19" version="1">MTVAAPPVAPVHENGMNGGAPGHHVNTMSLPRFHPIAMNPPQPIPPEHMMPAHHQFRPFHPPPLQEQGPPAPGPPGQPFQIDHIEARLRQLEHEEAARMAARSHLLAIRKREDEEFRRMTENAEAEEEELRRQRKRIKRESMGLGFNASLDSPPLRPTPPRRLSETNAATTLAFFKQQSPPEPRPIPPPAQAAPPHPPPQHIHHDPTGATSIRRKQKYTIKNVEAWGERHGRPAAHDPSGRALWKRPSDGSLVYLTCPVTGCGKADFVTLHGFMCHLTKKHKDRSLGSQSRALEVCGIVFDPNAPLPPVATVNRASTEESRLESGPADGEGYQQEMEYSSASDEEESREVPVKTEVSDRTLPAPPATMPPAPEQIPVPRMNGSTKQSISSIIDRDPEDEPRGRLSSIPPRPAEAPIQASPDQKPSIKDEAEFPRPHETEKENTDPKDTTEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT65</accession>
    <name>A0A8G1QT65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PEBP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_452977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511753.1">
        <property type="nucleotide sequence ID" value="XM_025660962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT65"/>
    <dbReference type="GeneID" id="37164364"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00457">
        <property type="entry name" value="PEBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049556">
        <property type="entry name" value="PhiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289:SF1">
        <property type="entry name" value="PEBP (PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="206" mass="22866" checksum="A0D79FA21902B184" modified="2022-01-19" version="1">MDKLPPRIEAFLGRLLRNKRGRDAKLLTRISPALQALQPTIAVTSSVGPSQSPLPAEYTQVGANRFPPLSWTVPNDSVPAEKLNSYVLIVEDADAPLPNPIVHGLYYGLSKDKTSISSDDVAVTDASKRALQGGFQYGVNWHQNVWSGPRPVLGHGSHRYFFQVLALGKALEEKPWGKEELLQWLEKEKESVLAWGEWVGTFVREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTP4</accession>
    <name>A0A8G1QTP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T1</fullName>
            <ecNumber evidence="2">4.6.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_157333</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].</text>
            <dbReference type="EC" id="4.6.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.24" evidence="2"/>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511324.1">
        <property type="nucleotide sequence ID" value="XM_025654202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTP4"/>
    <dbReference type="GeneID" id="37157604"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00606">
        <property type="entry name" value="fungal_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048269">
        <property type="entry name" value="RNase_U2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037430">
        <property type="entry name" value="RNase_U2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034820232" description="ribonuclease T1" evidence="10">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH53402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="141" mass="15738" checksum="3F0C69B899C575FF" modified="2022-01-19" version="1">MFQLKTILTLLPIFLTSTLAAPSPNTHTPSESRSDSKCVYYCGSHCYWASDISKAQAKGYSLHEEGRTIDDYPHVYHDYEGFDFTVSGTYYEYPILDDYKVYDGGSPGADRIIFNGEDEFAGLITHTGAEEYDGFVACQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTP8</accession>
    <name>A0A8G1QTP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_503725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511605.1">
        <property type="nucleotide sequence ID" value="XM_025664250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTP8"/>
    <dbReference type="GeneID" id="37167652"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="16"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH53683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="206" mass="22667" checksum="759E52EB8FA3AD93" modified="2022-01-19" version="1">MDSTANSSIDFGENYAVLNLDWITVLIDAVKDTPEGQALIENLAKWNHAVHESASRPLTVFSTLSFYPGQPEVQPGTPFANLIAPFGEFRHGSPETQIYKAFSVDSQDIVLPKTRWSAMTGSVLEQILQAHGVKTVIISGLTLSGVVMATIYRLFDLDYNVYVIRENVLELPVEQHSAFANVMLDMLLPKMGIKVISVDEAINALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTV5</accession>
    <name>A0A8G1QTV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_492861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510659.1">
        <property type="nucleotide sequence ID" value="XM_025663800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTV5"/>
    <dbReference type="GeneID" id="37167202"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH52737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="127" mass="13911" checksum="4A85F0D4AF7A1A45" modified="2022-01-19" version="1">MVFVAHRAGQALGLNLWPPSAAVTFATLPYLKIFYDSIYERMFGKLEQSWIAEVQPHQLNMNDGNALPVHLELDRPKDDNGILMTIDSEGNTGNLPDIILGGLAFPAISTSMGGLLKDTLVLYSHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QU29</accession>
    <name>A0A8G1QU29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD-40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_384246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510182.1">
        <property type="nucleotide sequence ID" value="XM_025656545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QU29"/>
    <dbReference type="GeneID" id="37159947"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001242">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="127"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="370" mass="40738" checksum="DEAE7DBB4D5D2446" modified="2022-01-19" version="1">MAEGQPQPTAQPQPQQPILQCQKVSDIIRSFRPTKAFRGPKQDTSNYVTSLDFDDQGDYLVASGDDETIQVFDIKEGKSTKSVPSKKYGAHLARFTHHSRQVLHASTKVDDSLRLLDLHNEGYIRYFQGHTDKVTCLALSPGSDSFISCSKDDTVALWDLGSRNAQGKLKLATPYLVAFDPSASVIAIASQSTASVLLYDLRNYDKAPFSSFDLAPYEERYTPSTRGRGWTRLEFSNDGKHLLVGTDYHGHFILDAFEGTVKAFLVGKAGSPGRAAPVSTTGKPLGQGDACFSPDGRYVVGGSGDHSDMLVWDLQQSPPEPNGLLQPMTRLSHRGRTAIVEYNPRYNMIASADKETVFWLPEDPSRSSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QU54</accession>
    <name>A0A8G1QU54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rhamnogalacturonate lyase</fullName>
            <ecNumber evidence="11">4.2.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_505535</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end.</text>
            <dbReference type="EC" id="4.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the polysaccharide lyase 4 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.23" evidence="11"/>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510903.1">
        <property type="nucleotide sequence ID" value="XM_025664336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QU54"/>
    <dbReference type="GeneID" id="37167738"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102210">
        <property type="term" value="F:rhamnogalacturonan endolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10317">
        <property type="entry name" value="RGL4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10316">
        <property type="entry name" value="RGL4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10320">
        <property type="entry name" value="RGL4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000102">
        <property type="entry name" value="Rhamnogalacturonate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1120:FF:000017">
        <property type="entry name" value="Rhamnogalacturonate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000020">
        <property type="entry name" value="Rhamnogalacturonate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016590">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015364">
        <property type="entry name" value="RhgB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574:SF1">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09284">
        <property type="entry name" value="RhgB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011794">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034457900" description="Rhamnogalacturonate lyase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase B N-terminal" evidence="13">
        <location>
            <begin position="22"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="15">
        <location>
            <begin position="277"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="14">
        <location>
            <begin position="361"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="50"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR011794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR011794-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH52981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="528" mass="57001" checksum="335E657784BB4015" modified="2022-01-19" version="1">MLSRTSLLSLLSLAAGVVNADFGITTNDDSYVINANSPNSLVFTVDRGSCDITSIVHYGTELQYSGKGSHIGSGLGTATVSATKSGDYIKVTCETDTLTQYMVVHDGDPIIHMATYITEEPSIGELRFIARLNPDELPNEEPFGDVSNTAGGEAIEGSDVFLVDGETRSKFYSSQRFIDDQRHCIAGDEHRVCMILNQYETSSGGPFHRDINSNNGGDYNSLYWYMNSGHVQTESYRMGLHGPYSMYFSRSGTPSTDIDTSFFADLDIEGYVAEADRGTVSGTASGADSSFDWVVHWYNDDAQYWTYTSSSGSFTSPAMKPGTYTMVYYQGEYVVATSEVTVSAGSSTTKNISGSVKTGTTIFKIGDWDGQPTGFRNAENQLRMHPSDSRMSDWGSLTYTVGSSSLTDFPMAVFKAVNDPVTIKFTATSDQTGAATLRIGTTLSFAGGRPQATINDYEGSAPSAPTNLNSRGVTRGAYRGYGEVYDVSVPEGTIVEGENTITISVISGSSGDEFLSPNFVFDCVELFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUQ7</accession>
    <name>A0A8G1QUQ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Kinesin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_452849</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH54003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511925.1">
        <property type="nucleotide sequence ID" value="XM_025660916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUQ7"/>
    <dbReference type="GeneID" id="37164318"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000051">
        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025901">
        <property type="entry name" value="Kinesin-assoc_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13931">
        <property type="entry name" value="Microtub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="88"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1045"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="484"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="675"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="751"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1117"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="175"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH54003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1190" mass="132649" checksum="127A143E312F7DFB" modified="2022-01-19" version="1">MAGPQRPASGLPTRRTTTTATRPATRPSTRRAGSTVPSSTRANSPAVIAKAPPSSSRAVKSPTESSTTSLIAKRKERDYEREINEDTSIHVVVRCRGRNDREIQEKSGVVVSTPEGVKGKCVELSMGPNALSNKAYTFDKVFSAAADQVTVYEDVVLPIVNEMLAGYNCTIFAYGQTGTGKTYTMSGDMTDTLGILSDNAGIIPRVLYSLFHKLQETESTVKCSFIELYNEELRDLLAYEDNSKLKIYENESKKGHGSTLVQGMEETFIDSASAGIKLLQEGSHKRQVAATKCNDLSSRSHTVFTITVLTKRITESGDEHISHGKLNLVDLAGSENIQRSGAENKRATEAGLINKSLLTLGRVINALVDKSPHIPYRESKLTRLLQDSLGGRTKTCIIATVSPSRSNLEETISTLDYAFRAKNIRNKPQINSTMPKKTLIREFTAEIEKLKGELIATRHRNGVYMSVDSWEEMHMESESRRIVNEEQRAKIESMESSLRHKVQELFTLTSNFNDLKKDNEETRAALANTNDVLEQTEIVLKDTKAQLEEEEMLRKAHEETETKLRDIGAGLLSTLDTTVEDISGLHAKIQRKTDLDATNKRAWQVSTAEVSNVTTVIDSKVEAFQEQHCELVEAMSEKINEFVTRELANIESNQSQLLQSAGLFDKAEREANSQTTGAHDEMNEVLEEIKDLREEVKRKVGEGLNGLSAAAARISKEVIGEFSEFHAQLHSSYSALGKDLKTVFEDMVTHLNGQKAEINKLRLELQEANTKAVEANRRASSHLAQTLEEESANAEAERDLLMSQMKALIEESRQRQFGRLKGRVETMRTDLTSSGDFLEHATAQYDRHVDEWVFKSEQFAKDVTASKDDIRSRMQSDWEVFDQRNASIQKVTESVHEETVRIVDAQVNNMSKQMEALDDFVAKARSQNGRYRDAHLSSLRNMSSNVHQSYDSVNTQFTELGGRLSELQEDAIQQQLNLQESTMPLSDEVRKPLTDLRENIRNRAFEEYVSTGVTPRKRAYDYPSDLPRTEGHDCLKTRMRTSRQFTALPFSGEDQLPTLDSSPGTPPSKGFVFNDTSEEVGSLPPKTAVTPSNTGLREVDANVVKPRASSAGDRKSSTAGTETPRTTMDLTPETEDTDQPPAKRRCSNLTSTDSKLSQKKLTRKMAGMLEGPENVPPPSSARRLRNQPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV17</accession>
    <name>A0A8G1QV17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abhydrolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_102810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512280.1">
        <property type="nucleotide sequence ID" value="XM_025653789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV17"/>
    <dbReference type="GeneID" id="37157191"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="128"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="406" mass="44785" checksum="44295DBA7E99527A" modified="2022-01-19" version="1">MPAGDLLASLLKHASFSAAIAVGLYATLLGLLTTQTFQSHVVYLHAFEMTWFKDLNVPETFGFLRNQVTPFTIWTPDGEQLYAWHILPVELYRQHEQSLVAEPAVLVSDITSRLSFQLLRDDPDARLILHMHGAGGTVGSGYRVPNYRALSAGQPEKIHVLTFDYRGFGRSTGQPSEAGLITDACAVVDWAMTVAGIPPSRILIFGQSMGTAVSLAITRDLAVQSPPVVFAGTVLVAPFVDVATLVSTYRVAGIIPILSPLARFPWLFESLQRFIRDKWLSKDRIAEYVRANEVNGERYHLTIIHAEDDYDIPSHHSQAVFWHAVRGTVPGGISYYELERKKPDTKVDLGAAGTVVEWKTDNGIIREQILKTGLHDTIMGYPVVTMAVMRAFESVNPAFTGLLPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVH8</accession>
    <name>A0A8G1QVH8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-acetolactate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_490809</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:21580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15686"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="4.1.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; (R,R)-butane-2,3-diol biosynthesis; (R,R)-butane-2,3-diol from pyruvate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-acetolactate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.5" evidence="4"/>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512535.1">
        <property type="nucleotide sequence ID" value="XM_025663677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVH8"/>
    <dbReference type="GeneID" id="37167079"/>
    <dbReference type="UniPathway" id="UPA00626">
        <property type="reaction ID" value="UER00678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047605">
        <property type="term" value="F:acetolactate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045151">
        <property type="term" value="P:acetoin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17299">
        <property type="entry name" value="acetolactate_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005128">
        <property type="entry name" value="Acetolactate_a_deCO2ase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01252">
        <property type="entry name" value="acetolac_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524">
        <property type="entry name" value="ALPHA-ACETOLACTATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524:SF1">
        <property type="entry name" value="ALPHA-ACETOLACTATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03306">
        <property type="entry name" value="AAL_decarboxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001332">
        <property type="entry name" value="Acetolac_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0005">Acetoin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH54613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="239" mass="26134" checksum="F90BE12D72EA94DF" modified="2022-01-19" version="1">MANCIYQYSVLGALMNGICQDGTTAQNILNHGDHGIGTIRGLNGELVIIDGVAYHFPANGPLRPVEAADIIPFAMTTRFQPTLTSHVPCISMSSLFDSLLPVFPDEQNVFLSVRLVASFSRVVFRVIPAQSKPRESLLALAKRQEIRECTRIQGTLFGFWSPRYTSGFSIPGFHLHLLSADRTVGGHVIDFAAEDGQLAAAVVRNYQVELPASEEFREAPLNCVKEQDLHTAEGSPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVI2</accession>
    <name>A0A8G1QVI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monocarboxylate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_503583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511544.1">
        <property type="nucleotide sequence ID" value="XM_025664238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVI2"/>
    <dbReference type="GeneID" id="37167640"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH53622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="172" mass="17834" checksum="74CADA518410359B" modified="2022-01-19" version="1">MRGADNATEVLGISEESGATLIIIINALGIPVRALLGYLADRYIGPLNCLIPCVALCGILIFFWAAVHTTVELYVFAVFYGLASAAAMALFVGTVPSLTKDLDKIGTRVGMALTIMSFGPLTGPSVAGTLIARTGGEYLAAQMWAGAALIVAVLALVAARLIISGPRVRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVI8</accession>
    <name>A0A8G1QVI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor 1-alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_377311</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513073.1">
        <property type="nucleotide sequence ID" value="XM_025656258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVI8"/>
    <dbReference type="GeneID" id="37159660"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000061">
        <property type="entry name" value="Translation release factor eRF3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
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        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="16">
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            <end position="514"/>
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            <dbReference type="PROSITE" id="PS51722"/>
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            <dbReference type="EMBL" id="RAH55151.1"/>
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    <evidence type="ECO:0000313" key="18">
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            <dbReference type="Proteomes" id="UP000249526"/>
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    <sequence length="728" mass="77966" checksum="48A058B9C2730954" modified="2022-01-19" version="1">MADQTPDSWEDELSRQTEGVRLNPNAQGRPQPQAPSFHPGAATFTPGAASFVPGQTYQPYGGGYPQYGQYGQQAYGGYPYDQQQQAYAQYGAYAQQPGGFNNNQVYNQQYGGYQQQQQPRQAAAAPAAAQPAQPAPKPAASNNAAPPKAKVLSIGGASNSPAAPKTKVLSIGTPSPAPTSSTPSSTSGAATPGDTKGAAAVEAAAKVTASKAIEKTEKKADAKAAASGKSSPTPSGRSSPGRSSPARGEAAKAARNADAVAMEQQADVDEATLKEIYGEKKEHVNIVFIGHVDAGKSTLGGSILYVTGMVDERTLEKYKRDAKEAGRETWYLSWALDLTNEERAKGKTVEVGRAHFQLPVKAADGSTITRHFSILDAPGHKSYVHHMIGGASQADVGVLVISARKGEYETGFEKGGQTREHALLARNTGVKTLIVAVNKMDDPTVEWSKARFDECTVKVGKFLENLGYKKSDLFFMPISAQRTTGIKDRVPTDLAPWYGGPSLLEFLSDMKVPERKINAPFMMPISAKYRDMGTMVEGRIESGVLKKNGSCIMMPNRTKVEIAALYGETEDEIPTGTCGDQVRLRLRGVEEEDILPGFVLCSPKRLVNCVKTFEAKIRILDLKSILTAGYNCVMHVHSAVEEVTVAALLHKCEPGTGRRSKRPPPFAAKGQTIIARIEVTSTAGAVCVERFEDYNQMGRFTLRDQGQTVAIGMITKLISAEEAAATQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVW3</accession>
    <name>A0A8G1QVW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_452791</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511863.1">
        <property type="nucleotide sequence ID" value="XM_025660907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVW3"/>
    <dbReference type="GeneID" id="37164309"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chromatin modification-related protein"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ING_fam"/>
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        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
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        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
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        <property type="entry name" value="Znf_PHD-finger"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF100">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN YNG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="18">
        <location>
            <begin position="366"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="194"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH53941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="418" mass="45293" checksum="867E981B77E21DF3" modified="2022-01-19" version="1">MSQAQDDPAAVLELFVHDVANLPAEINHLMEEIQAKDKIIQECRTTINSRDTSLQKFIRLNGSLTPNPKEEQYGKAIIQNLDKSQQLQDEKIQLSEKACVLLDRHIRKLDIAIHKLQSNGMLSNDPPIPSLFNNKDQYRDPPKIFFPDSTVENSSFPSPLNGTSANANVILGATQKLNSLGRNAAALALNSPTAARSSAPATPSGTIHFQRQQRESSAGAVENKRRRLNASLGTLPAASSNLRQSSLGPGTPKAGTPASSRAGSAGPRSTASTKKAVTKKVAPHQQLKKIKASGLNGKHTKRSSSASGRLKVSGTKQSPSAAGGDEDEDDSMLSSADISDSENADEGRRDEDMEDEEEDEGNEDTKVYCTCRSVSHGDMVACDNDNCEFEWFHWKCVGLTREPVGKWFCPQCSAKLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QW52</accession>
    <name>A0A8G1QW52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_452220</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512696.1">
        <property type="nucleotide sequence ID" value="XM_025660768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QW52"/>
    <dbReference type="GeneID" id="37164170"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000019">
        <property type="entry name" value="Threonine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="14">
        <location>
            <begin position="52"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="286"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH54774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="718" mass="82317" checksum="135AB9BADB980B0A" modified="2022-01-19" version="1">MSSEGAKDLPVRSAADAKPAGDGLPDFIVERNNFFEELWQQYLEELKNKPHPEIKVNLELGDGNSIDVTANAWETTPAQLLKNVPKELSANVVLARVGKELWDLSRPLEGDCTVSYVPFDHPEGREVFWHSSAHCLGEACECEYGCLLSHGPPTPQGFFYDMAMPDNRVVRETDWPLLDRHANRIFKEKQSFDRLEVTKENLKKMFAYSKYKLHYIDKLVTGEKSTVYRCGTLVDLCRGPHIQSTGKVKTFKIMQNSSAYFLGDQSNDSLQRIRGVAFPDKKQMSEHLKFLEEAEKRNHVKIGKEQELFFFDEVSPGCPFLLPNGTKIFNALQSLLRSEYRKRGYQEVQTPNMYDVGIWKTSGHWAHYKDDMFKLDVEKREWALKPMNCPGHFVLFGHRERSYRELPLRIADFGVLHRNEASGALSGLTRVRKFQQDDTHIFCTQDQITSEIEGLFDFLQSIYGLFGFTFKLKLSTRPEKYLGELETWNYAEEQLKAAMTKFKGNDWTIDEGDGAFYGPKIDITIADALKREFQCATIQLDYQAPINFKLEYMSNEKASADAAKEGEAKPNEPGPGRARPVVIHRAIIGSFERFLGILIEHFGGKWPFWISPRQILIVPVMPAVNDYVEELQTILRGDKLNVDIDLSGNTMQKKIRTGQLQQYNFIFVVGASEKESRTVNIRNRDDPATQKQGVMIPLDEVREKLRVLRKERRLVNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWD2</accession>
    <name>A0A8G1QWD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerophosphocholine phosphodiesterase Gde1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_461772</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513015.1">
        <property type="nucleotide sequence ID" value="XM_025661809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWD2"/>
    <dbReference type="GeneID" id="37165211"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08606">
        <property type="entry name" value="GDPD_YPL110cp_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14484">
        <property type="entry name" value="SPX_GDE1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
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            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
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            <end position="523"/>
        </location>
    </feature>
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            <begin position="529"/>
            <end position="561"/>
        </location>
    </feature>
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        <location>
            <begin position="812"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="592"/>
            <end position="631"/>
        </location>
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            <begin position="1140"/>
            <end position="1197"/>
        </location>
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            <begin position="598"/>
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    </feature>
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            <begin position="621"/>
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        </location>
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        <location>
            <begin position="1178"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH55093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1197" mass="131206" checksum="B19D85315D0D645E" modified="2022-01-19" version="1">MKFGRQLAHKVVPEWGDDYIKYKALKKLIKAAAEKVKAGQEADLAGFFYSLDRNLEDVDHFYNKKYADFSRRLKLLEDRYGQSLDGGQRLDSQDVEDLLAALLELRSQMRKLQWYGELNRQGFVKITKKLDKKVGAQAQQKYLQTKVDPAPFASNTRVTDALRKINDRLSVLGEQKVDDDASSIRSSLSLKNGPARPNLNLPASMLQTVDEALRKDDTHVLLELLETLKAAADESGEDVYPKVLSSLLQRSINYRSTRCISVLLGRMDSLDEEDDINRRNCIHRLVISIGRAQSTTDSEQSASMVLDFPLETSNYITPAALPTLQPPRPVIMEAGQPSHLDRSDPSVSVLQHLLDQLQPNQRGALIAKDIAGRTPLHYAAQYGFKVVCEVIIEHLQAWDLFDVTEGIDGPRWQDNDGWAPLHLSVVGGHPLTTRALLEAENWHGANKDKAKIRKQVSRSSAVLALATKANFVDIVKLLVEAGVDINYQDEQGETALHVAARFGHDKCAKILLEGNGEQKADTELAENTYSWTPLFIACVDGALSVVELLIQAGANLERCDSSGWTAKEHASLRGHLDIARCLAKVTPAPTISESEPVIPVPPVASDPPSPPPSSLAERRSNGTPVPTSLRNAEPIKTFGHRYLTDESMILVSLGTMDMRAHTAAVNLDRIPMENAHSTQLDTALSLVVSANGAHGEPEVIDLPVHDNISTEPIVFHAADATKVRLLFDLIPTYAGSKDKVVGRGVALLSSIKQSVGSNRINLKGDSTVPIVAANTLEVIGSVTFNFLIITPFKHPNMTVTGEQTYWRSMSSTMVIGHRGLGKNMASRNSLQLGENTVQSFIAAANLGASYVEFDVQLTKDHVPVIYHDFLVSETGIDAPVHTLTLEQFLQLGDKGPARRPGSPLPGTDGIGEGMTAAFRQRSMSVGGSEYDPTELNEKIKHTRDFKKKGFKGNSRGNHIQAPFATLAELFQKLPKSVGFNIELKYPMLHESEEEEMDTYAVELNSFVDTVLTKVYDMGQGRNMIFSSFNPDICLLLSFKQPSIPVLFLTDSGASPVGDIRASSLQEAIRFASRWNLLGVVSQAEALVLCPRLVRVVKESGLVCVSYGAINNDPENVKLQVAEGIDAVIVDSVLAIRKGLTEHEGKGDTPGVSPQPSPLARATSGSLKESLNVPVLNHTEQKDDHLHVRPEAITSNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWG3</accession>
    <name>A0A8G1QWG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_491364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512024.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWG3"/>
    <dbReference type="GeneID" id="37167113"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034756364" evidence="1">
        <location>
            <begin position="20"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="77" mass="8865" checksum="C9D9BCA00FC9564A" modified="2022-01-19" version="1">MRFTLLASMALLGLALAAATESSTDDVGSTKVSDGTLDVNYCGERCEYDWECRRGNRCHECRKQHHERYGRCRERYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWT7</accession>
    <name>A0A8G1QWT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_451486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025660602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWT7"/>
    <dbReference type="GeneID" id="37164004"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="60" mass="7250" checksum="BCB65A0028A139F4" modified="2022-01-19" version="1">MARTFVKKKKRKKERSNSIPGYTRTGEMKKKKHKRKKHDLNTADAIHQLIFFFSLFTYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXB8</accession>
    <name>A0A8G1QXB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_441043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512519.1">
        <property type="nucleotide sequence ID" value="XM_025658795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXB8"/>
    <dbReference type="GeneID" id="37162197"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="158" mass="17138" checksum="B0718EBB0642046D" modified="2022-01-19" version="1">MDTPGISGGEDDPSHQSYQRRVSGGRKSQNGATLRNLQATSRGVAEFSVIEEGLGADGNSSDARNTSLKPMICQEAHTAYHWSSMWKTLCSADLFRRLPRFQRGLLAAKPVSNDVSTSEASCGSFLRCHAWDGGGSLSCKDNPGFNIYSQHYTSGFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXT0</accession>
    <name>A0A8G1QXT0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_452436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512491.1">
        <property type="nucleotide sequence ID" value="XM_025660821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXT0"/>
    <dbReference type="GeneID" id="37164223"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="552" mass="61919" checksum="E8327283DB5B6CC7" modified="2022-01-19" version="1">MSLTQVNPTEAVTQADRLPMTPPKGLSGLPILLKGRSNYTDWEFHLECAFRDAGLEDLIDLKLPKPANTHAKYAAWHNYSMTVAYYLVGQLGDEVVRQFRRSKEDKKYVDDAFKLIRTIVLGHGVVDCQIVVMKLTRGMRSDYSTARQYIDDFMEAYDVAVKLDCSISPFVASLLMMYELQSEFPTWASTVEHSMPGNAGQAYTEEQFRDLCRSALEECKRSEIREFGAAAVGKGKGQNPSNKPDATKDQWKAATFPKRGVSAKYHAAKMRKKSVNADGSCGYCRSKGHKPAKCWYIDPESRPVGWIPYILDIWFYRGSNNERSKRSDSNSKDDSKAAAPAPARQIAETPAQHVTLHETESDNKNSHILNFSGLAVGSTTDRSLHWIYSTGSSQHLTPDRASLNEYHELNASNFYKYRTSDGSVGVAKSAGYQTLLLSANNERLEVKVKAFYQPDLAYGLLSADRLRKEFGIYANTKDLTLRREQDDKVVGHLQACKNVLFVRTEDAGLALAVVDPLLLHRRYGHAGRLPPLRKINKLNSNTVRTSTARRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYC4</accession>
    <name>A0A8G1QYC4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_376046</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513800.1">
        <property type="nucleotide sequence ID" value="XM_025656205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYC4"/>
    <dbReference type="GeneID" id="37159607"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20346">
        <property type="entry name" value="BRcat_RBR_ANKIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16625">
        <property type="entry name" value="RING-HC_RBR_HEL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000007">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="232"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="236"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH55878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="610" mass="69262" checksum="14B1E5083F623C6E" modified="2022-01-19" version="1" fragment="single">LATGRNAFTTPPLTRKRKAAAATLVDNEPKTAATKASVALSPAATATSSSAQSSRKKQKPAVQDPDSDYTLATPGSFSVPVRSKEEKEEEDIDTPASTSMESDEDFMSVGSSPDDFLDTQGSDVESLGEDFGDDFDGGFSKDKDIIATKRKPYEVEFTVLSPEDIDREQNLQINEVSSILGLPPESSAILLRYGRWNREKLIESYMDHPEKTLEEAGLGTNFDGTPKTEVIPGFVCDICCEDGDDLETYAMRCGHRFCVDCYRHYLRQKIREEGEAARIECPSDSCNMIVDSKSLGLLVTNDLKERYHALLTRTYVDDKDNLKWCPAPNCEYAVDCPIKQRDLRRVVPTVQCDCRHYFCFGCTLNDHQPAPCTLVKMWLKKCEDDSETANWISANTKECPRCHSTIEKNGGCNHMTCRKCKHEFCWMCMGLWSEHGTSWYNCNRYEEKSGSDARSAQARSRASLERYLHYYNRYANHEQSAKLDKDLYLKTEKKMTSLQSQSGLSWIEVQFLDTASQALQQCRQTLKWTYAFAYYLARNNLTEIFEDNQKDLEMAVESLSEMFEKPVPELANLKVDILDKTAYCNKRRVILLSDTAENLKNGEWSFNVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZW8</accession>
    <name>A0A8G1QZW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_479401</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513869.1">
        <property type="nucleotide sequence ID" value="XM_025662952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZW8"/>
    <dbReference type="GeneID" id="37166354"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="62"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH55947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="450" mass="51343" checksum="A569C22C0EDEE47E" modified="2022-01-19" version="1">MAKRLAQSLRAWSALGRKSRTSFHGTGLELPPEPKTEEEKVPGFKPSAYFPVKPGYIFNDRYEALTKLGWGVSSTVWLVRDLQQWKWLPERYLTQKIGTCNYAEGHESHELNMEKCIRDANPNHLGHSILRTFIDSFEEKSPNGTHICLAYEPLREPLTLLQGRFINETFPLDIFKAYMKFLLLGLDYLHSECKIIHTDIKAANILITIEDPSVLHSFAQSQPSKPMSQKTIGDYTIYLCHNNFGRPKSLDFLPVLSDFGSAQFQLDNVTNTWPIQPDCYRAPEVLLGAGWSYSADIWNLGVMMWELIEDKILFSNARDSNLRGTPAAHLAQMIAFLGPPPQELIAREKEGLNRTFGIGLRNPDGKLCNSPAEWFDGPFFDENGEFLHKHLIPENQTLEDTVTCLKGTEKDEFLAFARNILHWLPEDRKTAKELAEDPYLSEITITVKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0B7</accession>
    <name>A0A8G1R0B7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Peroxidase</fullName>
            <ecNumber evidence="22">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">BO85DRAFT_459912</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Forms a one-to-one complex with cytochrome c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DPH4 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="22"/>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515100.1">
        <property type="nucleotide sequence ID" value="XM_025661684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0B7"/>
    <dbReference type="GeneID" id="37165086"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000006">
        <property type="entry name" value="Diphthamide biosynthesis protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0349">Heme</keyword>
    <keyword evidence="17" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11 22 27" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="25">
        <location>
            <begin position="114"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="24">
        <location>
            <begin position="372"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="26">
        <location>
            <begin position="487"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00006169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00038574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="RAH57178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="561" mass="62164" checksum="C6AA713ACA73F9AA" modified="2022-01-19" version="1">MASAARTASRAFLRSTPATSSFRPAARSARFALPSQGFRAASRRGYASEAGEAKSSNSLLWAGIAAAGGVGAYFYLKGGDASVSSKEFVPTKEDYQKVYDAVAQRLANETDYDDGSYGPVLVRLAWHASGTYDKETGTGGSNGATMRFAPESDHGANAGLKHARDFLEPIKAQFPWITYSDLWTLAGACAIQELGGPAIPWRPGRQDKDVAACTPDGRLPDATKEQSHIRDIFYRMGFNDQEIVALVGAHSLGRAHTDRSGFDGPWDFSPTVFTNEFFRLLVEEKWQQRKWNGPKQFTDKTTGTLMMMPADLALTKDKAFRKYVELYAKDSDLFFKDFSNVFVKLLELGVPFKTEDRYVFKTSESNHPLTQDHYEVLNLPFTETPTALSKQQLKAAYHKALLKHHPDKAPGAIAKDVQTSSTSTSSLPTSDTNSSSHTTHRYTIDEITTAYKTLSDPYLRAEYDRSLRLDRARVAEREKTGTVFHTGLEVVDLEDLACDESDADAALWYRGCRCGDERGFLVTEQDLEREAEHGEIVVGCRGCSLWMKVLFAVEDGDEEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0P2</accession>
    <name>A0A8G1R0P2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_450769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514036.1">
        <property type="nucleotide sequence ID" value="XM_025660456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0P2"/>
    <dbReference type="GeneID" id="37163858"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034446872" evidence="1">
        <location>
            <begin position="19"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="299" mass="29527" checksum="40C15FE33A4BF392" modified="2022-01-19" version="1">MKASFITLLAALATSALAAPTGGVPGVSEVTKTVNIGSVSSNVISTPSASASAGATGHIVQDAGNGVNQVLTVTGADAKKLLVQLSPEVANLLSGLGLPGLGSSVGSIIKTAGSVGDLLKDVGKVVDGLLTVVDKDGRALLIQLDPVVTGLLSGLGLPELGVPVGSIVGTLGENLKRSADGEIVQDLAPKVKDVLEVTGSDSKRLLVQLSPSVASLLSSLDLPTVGTSVGQIIKTAGSVGDLLKDISTPVEQLLTVIGQDGSYLLIQLSPNVASLLTGLGLPSLGTSVGSVVATLGQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0S8</accession>
    <name>A0A8G1R0S8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">xanthine dehydrogenase</fullName>
            <ecNumber evidence="4">1.17.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BO85DRAFT_398736</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24670"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>xanthine + NAD(+) + H2O = urate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="20">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="20">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="4"/>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515201.1">
        <property type="nucleotide sequence ID" value="XM_025657067.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37160469"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.120:FF:000016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000015">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000003">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000002">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 20" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 20" id="KW-0408">Iron</keyword>
    <keyword evidence="12 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 20" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="21">
        <location>
            <begin position="30"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="22">
        <location>
            <begin position="261"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="1290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="379"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="793"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="824"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="828"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="906"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="938"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="940"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1036"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1105"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RAH57279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1358" mass="148524" checksum="F4559B413C3E2471" modified="2022-01-19" version="1">MAPGILESPKPTVAASKAVTLAQLTEDWDDTIRFYLNGTKVVLDSINPEVTLLEYLRGIGLTGTKLGCAEGGCGACTVVVSHFNPTTKKLYHASVNACLAPLISVDGKHVITVEGIGDVKNPHAVQQRLAVGNGSQCGFCTPGIVMSLYALLRNNSAPTEHDVEEAFDGNLCRCTGYRPILDAAQSFTAPKGCGKSLANGGTGCCMDKRDGAGGCCKQSSADTTDGDAPKFTPPDFIEYSPGTELIFPPQLHKHEFRPLVLGNKKKKWYRPVTLEQLLEIKAVHPDAKIIGGSTETQIEVKFKAMRYSASVYVGDIPELRQYSLKDDHLEIGANVSLTDLESICDEALERYGPLRGQPFNAIKKQLRYFAGRQIRNVASPAGNLATASPISDLNPVFVATNTVLVAMSLGEVIEIPMSQFFKGYRSTALPPNAIIACLRVPVASETGEYLRAYKQSKRKDDDIAIVNAALRVSLSPSHDVQSVNLVFGGLAPMTVSARNAEAFLAGKKFTNPATLEGTMGALEKDFDLKFGVPGGMATYRKSLALGFFYRFYHDVLSSIQVTEADVDEDVIAEIERAISSGEKDHEASAAYQQKILGKASPHVSALKQATGEAQYTDDMPLMKNELYGCMVLSTKAHARILSVDTSAALDIPGVANYVDHTDLPNPKANWWGAPNCDEVFFAVDEVTTAGQPIGMILATSAKIAEEGARAVKVEYEELPAILSMEEAIEAESFFEHSRFIKCGDPESAFKEADYVFTGQSRMGGQEHFYLETQACVAIPKLEDGEMEIWSGTQNPTETQTYVAQVTGVAANKIVSRVKRLGGGFGGKETRSVQLAGICATAAAKAKLPVRCMLNRDEDIATSGQRHPFFCRWKVGVTKEGKLLAFDADVYANGGHTQDLSGAVVERALSHIDGVYKIPNMHVRGRICKTNTVSNTAFRGFGGPQGMFFAECMISEVADHLQIPVEQLRWQNMYKPGDKTHYNQELKDWHVPLMYKQVMDESSYEERRKTVEEYNKKHKWSKRGMALIPTKFGISFTALFLNQAGALVHIYHDGSVLVAHGGVEMGQGLHTKMTMIAAEALGVPQSNVFISETATNTVANTSSTAASASSDLNGYAIYNACEQLNERLRPYREKMPGAPMKDLAHAAYFDRVNLSAQGYYRTPDIGYVWGENKGQMFFYFTQGVTAAEVQIDTLTGDWTPLRADIKMDVGRTINPSIDYGQIEGAFIQGQGLFTTEESLWHRASGQIFTKGPGNYKIPGFRDIPQIFNVSLLKDVEWENLRTIQRSRGVGEPPLFMGSAVFFAIRDALKAARQQWNVQEVLRLESPATPERIRVSCADPIIERARVVPKEGEKSFFVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R124</accession>
    <name>A0A8G1R124_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_520181</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515351.1">
        <property type="nucleotide sequence ID" value="XM_025665112.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37168514"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="937"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="604"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH57429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1342" mass="151079" checksum="8DE0F9EE74F0062A" modified="2022-01-19" version="1">MTRLRGASVSSYEVSHGGIDRPQFHRSKLPPNAPDVIAQNTVDVSDPAQVLLWCRDERRRQFNLLVRRYKNQLLYGCQDPGCQTPTCASYRKRVTEGPFRRYTELSARTLACYLASLDNAEDGLCRNLSRVPCELSPQEYQRRSKRRNRTLPSNEPARERTESRSGDHTGLDGVLRPSPVRNVHSSSFNDRNGRSLSPCVESQDLTAVIPEETPATQRMKDPKSFTQNLFDTLSLRMIEWLPLRRSPSSLGPDSDRIDTRTESQSPKPECDGTQPYSDKPRPNLTRQRTPQHTVSATAAPQTPSSRHGNGQLAALELKLPNQQVKRLSLTDVDQWRQNPRTSLEEKSYQELKPARKLTVNTHVNGDETHNVPSPPALRHRPQKHRGRTADGNYPLPQEQPKKGRRVSWDGAKYLNNVLLDESEKPEPQSDEQPPPETESPSARKPKRRSSSQNKSISSIQSLSHLTDEIIDGMTQMMILSEDEAELWKDELTYMESTGSFEESEWRFATPRQREVFSFVSQSVFYALGNTKQLLLSFRQKSAGPTGMNEGHSKPKLDLQQLQPSLRKLLRLCPRDIVFHSLWGATETLFIPPKELSMSGKLSRRSSSNSTNAAPSAPIIRRSDSEGNEYFTDANAADVATLAIFALASSLPEIDAPTWRAILRMRAAGGVSSSSDMQKLSIPRARLVVETTDMLEHELALRLLDRLVRALTARLAFHEISKARQVYSRDLPKQRKNSVLDLIVNNLSEHYGAMTAAIGDLDHTPPPGAPAFIAEWLRTLLLKEWDGNPQLSKSSSAGGAVQILSLLYKERSRLGLVPEDFHTPFLSDRLEPLDMPVEWMGSLPNNKTMHLLSYPFLFPPSALVIYFRALNYAAMSKYYEAAMTTTRHVTQTAFGPIQVQDDVGLLAQLKTSMSTYLVLMVRRDNILIDALNQLWRRERRELMRPLKVQMGMDEGEEGLDHGGVQQEFFRVLMAEALDPSFGMFTTDARTRISWFQPCSWEPLYKFELLGLLMSLAVYNGLTLPVNFPTAFYRKLLGLKVKHLEHIQDGWPELSKGLGDLLTWEDGDVGDIFMRTYEFSFEAFGAVETVDMQRVDKDAPWPVSSMPSRARSGSRSLGYSPPWSEVRHFADHADLSPPSSMAAETAGSYGEATKPIDTLVPAQSPTPPADEASLVTNSNRAQFVKDYIFWLTDKSVRPQFEAFAQGFYTCLDRTALSIFTPEALKTVVEGIQTIDIRELERHARYEGGFDPSHRVIRDFWSVVRRYPAEKKAQLLEFVTASDRVPVNGIASIMFVIQKNGVGDARLPTSLTCFGRLLLPEYSSRSVLEEKLSKALENARGFGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R159</accession>
    <name>A0A8G1R159_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1479-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_496469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514544.1">
        <property type="nucleotide sequence ID" value="XM_025663956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R159"/>
    <dbReference type="GeneID" id="37167358"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH56622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="496" mass="55532" checksum="842E40C1C7368553" modified="2022-01-19" version="1">MIKTVSPKCLNCPTFRAGKCAGTAKRLVATDTSPITRKDKREGDISSVFTSFSGRKSVPLPERFRDLKRNLTTGFEDQIQKSWDELVEVLKVRTEEVATKRESIIPQLNFSDIQAGNVSPANIAAIRRTGVAVIRGVVDKDVTEKLLSDVRQYLTSRPFKGFPSTSDKKVIYESYWSPSQVKARSHPNMLATQAWMNQLYTADANQKIDISVPLSYCDRIQIRPPGDKLFGLPPHVDGGGVERWEDRAYNHTYRKIFQGKWQEYDPWDLTGRLDANMNMYDAPGGCSVFRTFQSWLGLSRHGPQQGTLVVHPILQPTTAYWMLRPFFKPTRKDSLDGWKFSLDDDEGDIFLHGANPGTAQEHTPTLHPHLRLAETMIPYPTVEPGDTVFWSADTIHGTEMENTGNIDACVFYIPSVPLTPNNMQYVKQQREAFLKGVPPPDFPGGSGESQFSDRATIADIQSEAGKVAMGLSPIKLNGKDEKSKKLGQNMNAMLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1M3</accession>
    <name>A0A8G1R1M3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_397756</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515510.1">
        <property type="nucleotide sequence ID" value="XM_025657034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1M3"/>
    <dbReference type="GeneID" id="37160436"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000193">
        <property type="entry name" value="Protoporphyrinogen oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="12">
        <location>
            <begin position="43"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH57588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="597" mass="65741" checksum="B117F21D34D45BE1" modified="2022-01-19" version="1">MRLPCASSRAFRQVRAPLALLHRGQRHAVHTKQFDAAVIGGGITGLTAAYQLSRDPSCSKVTLYEKSSHLGGWLSSEQIPVRGGHVVFEYGPRTLRTSSPSCLPMMDLIMNLDLLDDVLICDKKSPAAQNRYIYYPDHLVRLPFPPTEGLLKTAWTLLMEPLFETFLYSAIFEKPKRAENAHILSRDESVADFVSRRFSPKMSENLASAVMAGIFAGDVNRLSAEMAIGYVRELEKRYGSIVDGMMTQRASGMRAMPMDELLALESVAVPSHSDDRYWKSLRAVVSDASVLTLKNGLGQLTDAMAAQLRSSSNVEVVTGTEVTSLSQNPKTRDLTIGFGTNESKTHNRVIATHAPSSLARQIENTKVGVVPSDTIRALGQNNYAATVMVVNLYYEDPDLVPVEGFGYLLPSSVPFEQNPERALGVIFGSQSSEGQDTAPGTKLTVMMGGHLWDGWSESDYPDPDKAVEMAQALLHRHLGIKTAPSVARARLLRDAIPQYTVGHLSRMKELSHSVRSDFHKRLTLAGAWYGTVGIGVVDCIRQGYLASSYGVGSKKLGPGNSRRPWTKHDFHNWELEGGIATSPVRFDNVHVTERQHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R279</accession>
    <name>A0A8G1R279_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_449886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515084.1">
        <property type="nucleotide sequence ID" value="XM_025660262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R279"/>
    <dbReference type="GeneID" id="37163664"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="170"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="258"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="416" mass="47633" checksum="143264A4170D83D8" modified="2022-01-19" version="1">MATTLWDPDRILQITKGPHDQGMFCLGRARSRYDSRCRWDIPYSDYQIIRKSLSQLARKLPHEISDDELKEIAERGLCDYHCGQVHEVVSGWHDTLASLQNLYSPYKDPGETRDTVFDALQATVKRSGDLLPPEEDSSAEDLSVYFGGHMREPSELVEARKQRDLQTTREKNLENCLALLKERLALCEENDRLREQNCANLQELLGEVKAELSDVQGNNSILTCTISDLQGACDLKMRQLTEMTAELSNVRGNNSSLIDANEEMRKEMRKEVDGKKKQLNEVTVELSNVRRANERFRIFNEDMRKEINCKQEQIETITSQLASMSTDLDSTTKELSVACETKEKVQNDLHAALEEISNLQAQLTEIQVQQSTTLWCKIKRWIQEKASSLSRDRRRRGIRDEDEEVALAPVKPSNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R287</accession>
    <name>A0A8G1R287_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_449177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515996.1">
        <property type="nucleotide sequence ID" value="XM_025660105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R287"/>
    <dbReference type="GeneID" id="37163507"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="72" mass="8240" checksum="894237DA35A47758" modified="2022-01-19" version="1">MPKLSRVSQLNQPYIVKSRLLVIQLKRARTLLVCFTPVSSSLSHPLIHTLKIESYLPLPYSMSQNRSTTCVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2Q4</accession>
    <name>A0A8G1R2Q4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ADP-ribosylation factor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_488296</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515493.1">
        <property type="nucleotide sequence ID" value="XM_025663520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2Q4"/>
    <dbReference type="GeneID" id="37166922"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001015">
        <property type="entry name" value="ADP-ribosylation factor-like protein 8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH57571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="183" mass="20656" checksum="A1CF97320EDDB4DB" modified="2022-01-19" version="1">MAGIFRTIYDWLLRMFWATEMDVTMIGLQNAGKSSLLRVLAGGEFTVDSIPTIGFNTKRVQKGHVTLKCWDLGGQPRFRPMWERYCRGVNAIVYIVDAADRAALPVAKEELHELMNKETLNGIPLLVLGNKSDLPEKLSVDDLIHEMDLKSITHREVSCYGISAKEETNLDAVLHWLIARASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3V7</accession>
    <name>A0A8G1R3V7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine N-methyltransferase 2</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_259477</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516911.1">
        <property type="nucleotide sequence ID" value="XM_025655016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3V7"/>
    <dbReference type="GeneID" id="37158418"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019702">
        <property type="term" value="F:protein arginine N5-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000135">
        <property type="entry name" value="Arginine N-methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017408">
        <property type="entry name" value="Arginine_N-MeTrfase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026480">
        <property type="entry name" value="RMT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038148">
        <property type="entry name" value="Arginine_N-mtfrase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51559">
        <property type="entry name" value="SAM_RMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RMT2" evidence="10">
        <location>
            <begin position="208"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="162"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH58989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="432" mass="47874" checksum="A0C06B121E007D86" modified="2022-01-19" version="1">MADTDPVITFTQDPNMALNLDLNIQEILLAASTHNIPLLRRLIRENQTPGNPANVKDPETGFSPLHAAIAACEEEGEENNDAEKQTNGVDTNADGDSAGGVVETVKFLLGEGAIWNDLDLNDETPGCIARRLGLMEVYEMIVDAGVRAELLLGRLEEGWEALGDDDDEDEEEQEGEGVEEAATTAVEAEAEPATTEEQPAAAAAAEDPSVTQPRYLDSNLTFANDRLLDSDQNGVMMSWESTIMEKSAAKLLPTPGLRVMNIGHGMGIVDTFLQSHGPSEHHIVEAHPEVVAEMKRKGWDQKPGVRIHEGRWQDVLPALVGEGVVVDAIYYDTFAESYSDFREFFSEQVIGILEQDGEHGSGRWGFFNGMGADRQISYDVYQKVVEMDLFEAGFDVEWEELEVPALEGEWEGVRRPYWRIEKYRLPICKFMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3Y8</accession>
    <name>A0A8G1R3Y8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_519938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515984.1">
        <property type="nucleotide sequence ID" value="XM_025665090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3Y8"/>
    <dbReference type="GeneID" id="37168492"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="103" mass="11798" checksum="4265D9A79F4A1E3C" modified="2022-01-19" version="1">MPDTKSMAMNEDDDRDGRPAHSEKDSFEKQRWVFTHGTSNKGGREYDRLFRLEPQKFLIEVAVDRPAGGRRRELPGTWIGVESPRQGNLESLPGHDSPYRSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R400</accession>
    <name>A0A8G1R400_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_396430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515761.1">
        <property type="nucleotide sequence ID" value="XM_025656999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R400"/>
    <dbReference type="GeneID" id="37160401"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF27">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="49"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH57839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="530" mass="56959" checksum="DD153777BD8A1095" modified="2022-01-19" version="1">MGTTTMSNELETHAPDTIKDVSHVQHVDFASDSRTFSKERTVNFFLLLTCAAFGSASLVFGFDDKIISPVAALAPFVDKYQGPEPLTGKLVLTARNQSILFSIPLIGSILGGLAASPLNSRLGRKCPLLIAYIISIGGSLLQVLAPNLGAFVSGRFINGIATGIANSTAPLYLAEVVPASMRGRSVSLINILTLVAGVLGTIVVLCTHDLRGSSSYRIPLTVQCVLPALLFIWTLPLPESPQWLVSKGRLEAARSNLRRLRCCSEQRVDEELRDMELSEGHASDVNVSFMKIFSKKHLQRTLTAGSFYSLNQVSGIILSTTYSTVFLSGIGIGDPFTLTVIASCCTLAGTIAAPFMLDRAGRRPTALAGMSILFVIDLAAGGLAFNKGNRHSAIAIAALSFAFNFFWASSFSPISTLLPSEMATPKLRHHTMAYTIACAQTTAVITTLVVPQLTARDAANLGPKTYLVFAGCMACILIFAYLFIPETKGRTFVEIDAMYNAKIPARKWRQYWSSLEKASGSDSQGSTKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R401</accession>
    <name>A0A8G1R401_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_371360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515999.1">
        <property type="nucleotide sequence ID" value="XM_025655998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R401"/>
    <dbReference type="GeneID" id="37159400"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034288127" description="peptidyl-tRNA hydrolase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="468" mass="51132" checksum="F76E7BCDCF7C1C2B" modified="2022-01-19" version="1">MRFTPVVALLPALAVAQEQVPLADRVQGWFNKAKSYLPTATPVAPAAAVVEKVVEKTKIQEKTVSEFNLTNWQSYLEPASEPQDWLVYITGGNKTCFGRCDKADKAFNESVLLFSADPTSPNLGKLDCEKNKVLCSAWGAGAPSVWFLQVPQAQLGEERPNTPLHTVYLNSTTVTPETIYKVHSEKVWEKAPAYDGPLHPTDGWLAQNNLLLPLGYVIYGFSAIPSWLFMIGISFFSRAVALETSAARPLLVRTRRARTINPKMSDLDRTTPSTAAYVVATAILAGITGYFIGQGSSLGLFSNKEKEGWPNSYNVKPHLDSSDEDYESEEEEDSEEEGDGTELANFDSSNEEVKLVLVVRTDLGMTKGKIAAQCSHATLACYKYLTAYTPNSGILRRWESQGQAKIALQVKSEEEMEEMQAKAISLGLCARVITDAGRTQIASGSRTVLGVLGPKSVVDSVTGHLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4I3</accession>
    <name>A0A8G1R4I3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidase FUB9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Fusaric acid biosynthesis protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_512114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517256.1">
        <property type="nucleotide sequence ID" value="XM_025664641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4I3"/>
    <dbReference type="GeneID" id="37168043"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="289"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="312"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00083297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH59334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="370" mass="40571" checksum="C6EA110890F68F7B" modified="2022-01-19" version="1">MANRPKDHDSKVLTIADLAIEAQKRLPPVVRDYFNEGAGDLITLKDNEAAYNRYKLLPRVLRDVDALDTSTTIFGNKVKFPLGFAPAAAHKLAHADGEVGTSRAAAAHDIPMCLSSWATTGIDDVIAQGTGNPYAMQVSFFRDVEITRRIIQKAEKAGYKALFVSVDLPVLGNRLNESRNNFNFPRDMRFPVLAEGIEELGLKDTYERGYDGSIRWDKTIAWLRQNTKLEIWLKGVYSPEDIQLAIDHKVDGVVISNHGGRQLDGVPATLDALRICAPVAKGKIPLAVDGGIRRGADVFKAIALGASMCFVGRIPIWGLAYNGEKGVDLAVKILYDEFCRTMKLAGCRTIADITPEHLAVLETNGLLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4Z4</accession>
    <name>A0A8G1R4Z4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major royal jelly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_519077</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517204.1">
        <property type="nucleotide sequence ID" value="XM_025665015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4Z4"/>
    <dbReference type="GeneID" id="37168417"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF18">
        <property type="entry name" value="PROTEIN YELLOW-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034706731" evidence="4">
        <location>
            <begin position="20"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH59282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="363" mass="38605" checksum="0E22F779BFDD001E" modified="2022-01-19" version="1">MPAALFLGLLGLTAPLAAATTSTPGLELAYSLERATQGISISSDGRKFLSQRYSTTLPPQIVELLDDNSTFLYPNTAWNSYNSSDPTSDPRKTFVSIDGARIGPDGRYWIVDGGSTGVNGSTKLVGVNLTTDAVDKLYYLDAMKASDSGIDDVRFNAAGDVAYMSDTAGALLVMNMTTGTGVRVLSTDSSAQPWFPMMYNGTLVPGYGAAGSTLSVGLDQIEVSPDGVYLYYQPCNGGLYRIKTVYVDASLKNATLASTLGDYAEPFALTPSTGGSTIDGDGNIYVSDTNLLAIWKVTPEGRATVLIQDEKLLWTDLMWVTADKKLWLPASQMRPGGDGLMADGPNYIFTYPIDAGPSPIDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R599</accession>
    <name>A0A8G1R599_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_370571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516674.1">
        <property type="nucleotide sequence ID" value="XM_025655967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R599"/>
    <dbReference type="GeneID" id="37159369"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="58724" checksum="91A3DF7A8C4B3B3B" modified="2022-01-19" version="1">MSDFFLMEDVWNEICEYLETGDLNSICLTSRTLNRVFTRYLYRKIQWDWNGKMSRYRIMSLWTTLVRNKDTRSRLCGLIREVHLLGRSPPQKTRINESPGIQECSSDLTSITKNDKMPFHQEIDYLRFIAGSIIESSKDRSDWYKSIAARNVYAMVALLPPFLHNLRSLKLDYTFLVNGGLPGVIIERLTSGDNIYSAELRNNFDHLKEIDYGTNALQNNLPRLRDNTHVPSCFSSQVIPIFRLQKMKHLKVWLRSHHGLRLWRVPGIQTDYTALKTLILDQISIMDCALFKILQRMKNLRTLHLGMNNEESGSWDHFKPSYNDGECILNGLEALYEYLEHLSISFSSTPLGREMTSDIDIWDPLFRSMMPGFFQDFTRLKTLELPVQLLNGFQDIEVSCINRGLPVTLERLGLRWDFQYVGREDGSTSHTVRVLQKLLANFLRLSDRHRRVPLLQEVIIRLFISDDEPDIAVEECDDLIEEFNMYVGVRFDYMRPGLWTNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5A2</accession>
    <name>A0A8G1R5A2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_448536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="4">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516421.1">
        <property type="nucleotide sequence ID" value="XM_025659958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5A2"/>
    <dbReference type="GeneID" id="37163360"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000005">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009117">
        <property type="entry name" value="ANX14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF179">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01813">
        <property type="entry name" value="ANNEXINFUNGI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0041">Annexin</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH58499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="506" mass="55806" checksum="6EF6B84335547DD5" modified="2022-01-19" version="1">MSYQQPYGQGPPQGYNQYPPAGQYPPPQGQYGQHQQYPQYPPQGPGPYQQSPSAHQPPQQHGSYPPPMAGHHPQQTQSPYPPQQQHPPQGASPYPPPMSGQHPQQPGPYPSYPPPQQGMGYPHQGPPSQQSYPQGHPPQPDYPNAPQQQYQSFPPGPPGQQPPPMMGPAGAGGPYPNYPPQQGPMPSRPSPGYDPTFLAPGTASNEAEALRKAMKGFGTDEKALIRVLTSTTDPNRMALIRHTYEKMHNRSLTKDLKSETSGSFETILVSLATGPLESDITYLHDAMSGLGTNEKGLNDVLLGRSNADLHAIQRAYRDKYHKSLLDDIKGELSGKTERFFVMLLNASRPEPGTPFDPRGVDTDVRELHRVTAGKMGTDEVALFGIFMNSSDERLNVLAGEFERMYHVSLEKVIRSEFSGHLEDALVTMLRVARDPVSFHGATLKECFFGSNGVNEKRLVYWTVRLHWNPEYFARVKGTMGGNMRSLVKSYVSGGDFEDAMMAVCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5F8</accession>
    <name>A0A8G1R5F8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_244699</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517459.1">
        <property type="nucleotide sequence ID" value="XM_025654871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5F8"/>
    <dbReference type="GeneID" id="37158273"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000640">
        <property type="entry name" value="Serine/threonine-protein kinase PRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="355"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="304"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH59537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="687" mass="75492" checksum="9E5BA3D0D0208B2A" modified="2022-01-19" version="1">MVHSDSAQPTDRSGSTVHQPQLHEANNPTASDDNEIGAPSAIVPGQGSSHTPPLYIEKSPAEGLQDVTLQHYSHPHHLPSLQIRTDLSNASQMSPPREPESFVHHSISSSSLPRRTPSLRGLFAGPPTSAGSLTLSPASLISSPQLLAMGDITPLPSPIGGMSPWKLPRRNSQSLSRTPSTTSRSGSSLGLRLSDSSQMLGACESRPRSRQYMLPDKLSETPIETPIVSPTKPRQGSGSKHSRNRSLSEYVPPGRAIPVKPRPIAVSGPGMPPGITASVSTDSKTNNNSNNLHREEYLAVHRGIALPTVRPPTPPRSSRSGSDERDDEPVITPLAAGPDEIYSVRSVRTQQRRKYRKIRQLGQGTFSQVSLAARIERRESDDETMFSSLQDVNLVTQKLVAVKIIEYGPAGGADEERLEVSLKREVDILKSVNHPSLVQLKAFGSDEKRALLVLDYCPGGDLFDVASSSPRPMSPQLIRRIFAELVGAVRYLHANFIVHRDIKLENVLVNLPMQAIETITDWRTYDRAVITLSDLGLSRRIPEPPESPLLQTRCGSEDYAAPEILMGQPYDGRSTDAWALGVLLYAMMENRLPFDALPGTRGDPAKLRARTPHRIARVEWSWYRYADSDDEWDPEKGKDLEGARDCVEGLLKRNTKRKSLDEIASMSWVKEAIDIPGELKRGDKEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6D6</accession>
    <name>A0A8G1R6D6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_446705</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518045.1">
        <property type="nucleotide sequence ID" value="XM_025659560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6D6"/>
    <dbReference type="GeneID" id="37162962"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="16">
        <location>
            <begin position="51"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="17">
        <location>
            <begin position="203"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH60123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="479" mass="53230" checksum="F083233A4ADE1827" modified="2022-01-19" version="1">MASRRLAFNLNQALRSKAALKAIQPVKRGFASPVTLPSTTQSTTLSNGFTIATEYSPWAQTSTVGVWIDAGSRAETDKTNGTAHFLEHLAFKGTNKRSQHQLELEIENMGAHLNAYTSRENTVYYAKSFNNDVPKAVDILADILQNSKLEPTAIERERDVILREQEEVDKQLEEVVFDHLHATAFQNQPLGRTILGPKQNIQTISRDNLVDYIKTNYTADRMVLVGAGGIPHEQLVRLAEEHFGGLPSKPPTSAALALTAEQKRIPEFIGSEVRIRDDTLPTAHIALAVEGVSWKDDDYFTALVTQAIVGNWDRAMGNSSYLGSKLSSFVEYHGLANSFMSFSTSYSDTGLWGIYLTSENVTRLEDLIHFTLREWSRLSYNVTSAEVERAKAQLKASILLSLDGTTAVAEDIGRQIITTGRRLSPEDIERTIGQITEKDVMDFASRKLWDQDIAMSAVGSIEAVLDYNRIRADMSRNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6I5</accession>
    <name>A0A8G1R6I5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C6 zinc finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_446971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518336.1">
        <property type="nucleotide sequence ID" value="XM_025659619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6I5"/>
    <dbReference type="GeneID" id="37163021"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="42510" checksum="FCE5E08EB09B6F32" modified="2022-01-19" version="1">MPSNQARDDSSRINHRSSSISDGYSSHSPSDLISAAASTPGTERSDMECDFTDTEKERLRLMNHYALHTSRSITDVIIPRDQHQSLWGEWVTELAFKHNFLLHGLLGLSALHLALKGVSPQRHTVIAIRHHDLGVAMFRSYLSNITPENHDAVFAFSCVVSLYTFGIQRPSEPTEDPIDRLHQVFSLIRGSSFLVKSDHDTMVRSRWSVLMLPHPFPPTVLSSELEDVLSKLLSRAAMAPEAARMGIYEPTIKTLRHSLAMSIMYRRIKMTFSYFAVICPPEFWSMVRIGEPLALSILANYAVTLDWLRSNIWMAYWGREIVVAVRKALPLDWHECIAWAVQEMERPSESDGLGRYSASISDSLQENDQITTSLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R731</accession>
    <name>A0A8G1R731_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_252197</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517788.1">
        <property type="nucleotide sequence ID" value="XM_025654944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R731"/>
    <dbReference type="GeneID" id="37158346"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000065">
        <property type="entry name" value="[Pyruvate dehydrogenase (Acetyl-transferring)] kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="304"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH59866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="438" mass="49498" checksum="6700D02EEF185202" modified="2022-01-19" version="1">MWKPSESLMNTIRHYASFPATGVSLRQMVQFGDRPSTGTLFRASQFLSEELPIRLAHRVQDLGELPDGLSEMPSIKKVQDWYAQSFEEIINLPRPTLTQEVKTRLLRPGRLNGGTSRILSETTQNPSIREGQYRSSPSSLLNGNGNGKGAAVGRRYYAPSDDHGDWPPELNDYNERFAKTLQHIKRRHDSVVTTVAQGILEWKRKRQRLQIDSTVQSFLDRFYMSRIGIRMLIGQHIALTEQTHVRQPNYVGIICTKTNVREVALEAIDNARFVCEDYYGLFDAPKVQLVCKEDLNFMYVPGHLSHMLFETLKNSLRAVVEAHGADKDAFPVTKVIIAEGKEDITIKISDEGGGIPRSAIPLVWTYMYTTVEQTPSLDPDFDKSDFKAPMAGFGYGLPISRLYARYFGGDLKLISMEGYGTDVYLHLNRLSSSSEPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7A4</accession>
    <name>A0A8G1R7A4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_414910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519328.1">
        <property type="nucleotide sequence ID" value="XM_025657664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7A4"/>
    <dbReference type="GeneID" id="37161066"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="734" mass="82236" checksum="6A047675DDCFB30F" modified="2022-01-19" version="1">MAYFQEQETDEDASYNSNIEEDENISKLDVLRFEGADTIVFIDPPSYVPNRSLQPQSEASIPHYVHSHTLLDTKSPYLTKLFDPRRQARMIKRSEFLGNLPDGIKYVINLTPPSTDDEAVAFTTELSCPLGIRTWTRELSRLDLPVDCVGGEDEGIETEGGSKKSALPSEYSDSRHRTGIVHILQALGGVNPCLDTPCKLWTFFALAKVFGIATIGHIKIHILTWLYDGTNACFIELHPEITYRIARGIECDYLCQDSFTVLVGEEALLRLANAGKPPRLQWPEVTFHGRQREPLDDEDRQRIEYASQSLVDRILEEYIQLTGSQMDWLLQLPSTMMISRHIDDCAEHCSLASDLLSSLKLYVRGHIVANMTRSVNTRSSRLNHYIDPCNYPEHDYTNSYNNMRYVERIISKTFWRTVRGEGYSDCLRKPDEKFRDMTIADLGGHLHLFQSENEAKLSYVSLEDILRAVNQFNNHVDFDSPKFVQREWGGGDIFIEKRGGSLPDLDSDIETDETPEETATESSMASVFDPIVFLQQVRTSLGDLTERMAKGCRQGAHFKLTDTITCLTNNEFRYLPLWAGGDDDGSGGVFTDQGIPNLETGGFSMPGPAIHTGSTAPSTTSYSNIAPSEGQSTVQCASHKATGSQWADVVSLVSSEGHAIEDESHGPTPDEKPEDTEDTFIDMDTSADDFEDYFDTDSEDNDTVIVGTPSQSEPIEETSELLEHMSLEMKADSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7K7</accession>
    <name>A0A8G1R7K7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_185268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518955.1">
        <property type="nucleotide sequence ID" value="XM_025654379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7K7"/>
    <dbReference type="GeneID" id="37157781"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="162" mass="18344" checksum="F2C24DD4EAEC9BFF" modified="2022-01-19" version="1">MVSASSGHLVYRSSGQTSIHIKGERLSIILFLFLTSNRNIHGLRRPPCHQNRALGVFGFFGGDCLTGLMTSAELRLGQSCNVTRRFTFALPHSRPRHQKSFDLIFSHLSPFQKNLFYFIPISLIFRPLLLPAIIDMIVLLPFFSVSVFPDLFGEEGLFQCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R873</accession>
    <name>A0A8G1R873_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_468194</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516447.1">
        <property type="nucleotide sequence ID" value="XM_025662242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R873"/>
    <dbReference type="GeneID" id="37165644"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF2">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034478477" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH58525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="545" mass="60603" checksum="224F5843E593A7F1" modified="2022-01-19" version="1">MTLRFLYLVTSLLTLFSLALGSNDCSIGTFQAFLDANGTAARVVYARHYAENSTFVNPNISSVTNPTQLPAVCAIQVNATTDVDTYFSFGVFLPDTWNERFFHAAQEGEDINWVDMAVGLRYGFASVATDTGHTGSDMDGVWWKNPESINDWAWRANHLTSVLGKFLVESFYGKKPKYSYFAGCSTGGRQAMKETQKFPRDYDGVIAACPAWWTTHQQLYNLKQTTYQAPQGSAHTIPMEMFAVIGAEAIRQCDPQDGLVDSIISDPLGCHFDYLPLLCTEAKNTSCLTGPQIETLHKIYNDWVETNQTFVYTHPLYGSEAMWNESGVIGNGSVGNEDSQLWYPQHILGLANFTVQDFDYSVVQYADKTDPGDSSADNYDLAEFYHHGGKLIHYHGHSDAIVPPGIGLYYRDHMAATLAPQGIDIDDFYRFFAIPGMEHCYHTPSTMGAPWYIAGPTQASTLSPSLYSVPGYRDAKHDIFLALINWVENGTAPDYIIGSRFNSSIEYTSNTIDKQRPICAYPKLAQYVGSGDIDDAANFECKALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8A5</accession>
    <name>A0A8G1R8A5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1446 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_485124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519315.1">
        <property type="nucleotide sequence ID" value="XM_025663299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8A5"/>
    <dbReference type="GeneID" id="37166701"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF2">
        <property type="entry name" value="DUF1446 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11420)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="2">
        <location>
            <begin position="514"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="626" mass="68635" checksum="04A40495CA058BF5" modified="2022-01-19" version="1">MAQRSVRIAGASGSNADRRHAIAEFARNYPHDPVDVIIADYMSEANMVASAARTVEQQQRKAQGTHGSSTIEAPGYEVGFLQALDPALSDLAKYGIKVAVNAGNTDTEGLYNVVKQMVEAKGLKLKVAWVSGDQVLSTVKAALSSGKSAFANIYTGESLSDWPFEPIFAQCYLGGLGIAAALSQGADIVLCGRVSDASPVIGAAYWFHGWNRTDLDQLANAFVAGHLIECSNYVCGGNFTGFKALEHIGTDGWSNIGYPIADISREGKVIITMQSYARGGAVTIDTCSSQLLYEIQGPWYFNSDVTAILNDIHFEQVSPNRVALHGVRSGPPPPTTKVGITARGGFQAEAIYFLVGLDIPSKARMLESQIRRLLSPYTPKFTSLQFSTLGSAPENPDNQDSATVCLRIVAQARHAEDLSPMHFLRSIVDTIMQGYPGATFHLDTRQGFPRPVYEYHVTLLPQSDINHQVHLPWLHQTLTIPPPPITKFYPSRQPSQSLTDNPTLDFGPTIRGPLGWIVHARSGDKGPDANCGFWVRHADEYRWLRSLLSVSGIKELLGEKYTANPELRVERFELQNLRAVHFLFRNLLDRGVGVTTTVDFLGKNVAEFLRARHVDLPVKFLERGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8R5</accession>
    <name>A0A8G1R8R5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="20">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BO85DRAFT_254143</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 20">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19 20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="20"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517862.1">
        <property type="nucleotide sequence ID" value="XM_025654962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8R5"/>
    <dbReference type="GeneID" id="37158364"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19 20" id="KW-0274">FAD</keyword>
    <keyword evidence="5 19 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12 20" id="KW-0520">NAD</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="58"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RAH59940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="305" mass="33519" checksum="09F4EFC2D1E773E3" modified="2022-01-19" version="1">MSAFSPDNITGAFIPSALFVAGTFFFKQELTPFAVALAAVLVGWKVFNNKPRKVLNPGDFQHFTLKEKNDISHNVTVYRFALPRPTDILGLPIGQHISLAATIGGKEVVRSYTPISSDNEAGYFDLLVKAYPQGNISKYLTTLEVGQTMKVRGPKGAMVYTPNMCRHIGMIAGGTGITPMYQIIKAIIRNRPRNGGNDTTQVDLIFANVNPDDILMKEELEQLAKEDDGFRIYYVLNNPPEGWTGGVGFVTPDMIKERLPAPASDIKILLCGPPPMVSAMKKATESLGYTKARPVSKLEDQIFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8V5</accession>
    <name>A0A8G1R8V5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_501223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519630.1">
        <property type="nucleotide sequence ID" value="XM_025664163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8V5"/>
    <dbReference type="GeneID" id="37167565"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034423206" description="Alpha/beta-hydrolase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="50220" checksum="EA87A6EE5B2A3C4C" modified="2022-01-19" version="1">MLYSKTAAFAGFMALSALSGVAASYNYAVADPYGLPEPVMIDFDDDGVVGGLYRPNTTSPLSRIGVYVMHAEQDYLNFSACHELPRRGFTTFCANNDASKSGYMTDINFEDMMTNVGQGMSYLRNLTEIDKVVIFGHSGGGAMMTAYQNIAENGVKACNGPERIYPCSDAMADLPAADGLILIDANYGLSTMALLSLNPAIVDEHSGAKIDQSLNLYNTANGFSESGANYTQSFKKAFEKGVVARNNRILKHAESRLAAINNGSGIFSDDEPFYIVDSMYVGFNNKFFAQDTRWIHHTTHPWPLLHRNGSITTQIVPSVRVPANFESFADNFEGGALKTTIKRYLSTLAIRVTDDFEYKVDGFEGIVWNSSQTAPLGNIGGVTVPLLNMGNTGHYEYLNAEKLHLAAGSKDAEIAFVEGAQHTIVTCTECETYPGEYGNTLYTAYNYMAEWLSKEGRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8W0</accession>
    <name>A0A8G1R8W0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiprotein-bridging factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_392880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518673.1">
        <property type="nucleotide sequence ID" value="XM_025656858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8W0"/>
    <dbReference type="GeneID" id="37160260"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000030">
        <property type="entry name" value="Coactivator bridging factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="9">
        <location>
            <begin position="87"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH60751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="154" mass="16756" checksum="87F07B22378BEBE6" modified="2022-01-19" version="1">MSDWDSVTRIGARHTGGPATRETVVKGKSALNAAQRQGLVIGTEKKYATGNAAGRSGAPEGQHLTKVDRSDDIVKPKTVGYQVADAIKKRRNEEGYKMTQKELATKCNTTITVVQDFERGTATPDQKVLSAMERVLNVKLRGTGIGQEKFPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R918</accession>
    <name>A0A8G1R918_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit KXD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">KxDL homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_447005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KXD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518371.1">
        <property type="nucleotide sequence ID" value="XM_025659624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R918"/>
    <dbReference type="GeneID" id="37163026"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051390">
        <property type="entry name" value="BLOC-1_subunit_KXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019371">
        <property type="entry name" value="KxDL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10241">
        <property type="entry name" value="KxDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KxDL" evidence="9">
        <location>
            <begin position="83"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH60449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="180" mass="19744" checksum="6D7CD2537CD1A9AB" modified="2022-01-19" version="1">MATHHYQSPSLPINVPSKAPAPANLYPITRVSGSPPDISDTSTTAGSRTSAGFSYSSGSIGGDYETSSASYSGVDVVDVLNDRMQDVFDPTPLDRGLAMQAQTSGQLNAKQRELLELQALAQRRLKGVRATFNDGIKVARETKRDLEWTQKRVNALKAKAENNFPDEYRRATKKYTFDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R987</accession>
    <name>A0A8G1R987_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_445287</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519806.1">
        <property type="nucleotide sequence ID" value="XM_025659225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R987"/>
    <dbReference type="GeneID" id="37162627"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000022">
        <property type="entry name" value="Bc1_14K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH61884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="122" mass="14347" checksum="C69644152333BC8D" modified="2022-01-19" version="1">MSAPSLASYIVKRPFLKRWMMPIAQWYTDASGYRRLGLKADDLIPEENDVVQKALKRLPPKEAYDRVFRIRRAFQCSISHTLLPASEQTKPEEDVEYLSPIIREIEKEKQEREDLDALVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9V8</accession>
    <name>A0A8G1R9V8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_189009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519059.1">
        <property type="nucleotide sequence ID" value="XM_025654415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9V8"/>
    <dbReference type="GeneID" id="37157817"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH61137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="165" mass="18829" checksum="AED52B29650B3D98" modified="2022-01-19" version="1">MRGEKKVKRQRKKVYTPLAMGRDSLHMGPSEWALGTYFEAPTPIIEVKRIPLCSWHRCSPISRKLTHTIQTINGNPACVRCNGHSDYPSRKGRKKSQDESLLWLSLNAALWWLRFPCMDGILASSPIAIGLDWLMLDFLCRLIDVKVKGIRRRQSIQSSRTGQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9X3</accession>
    <name>A0A8G1R9X3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_447102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518462.1">
        <property type="nucleotide sequence ID" value="XM_025659648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9X3"/>
    <dbReference type="GeneID" id="37163050"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF3">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="20"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="397" mass="42575" checksum="50A72C59BEBF22D1" modified="2022-01-19" version="1">MSLPPLIQGHCAPPFSPLRNTLTENLQAGEEVGFSLSVTVGNETVVDLWGGYADAARTQPWTANTITCIFSSSKVITNLAANMLIDKGLLDPSAPVARYWPEFAANGKETILVKHVLSHTAGLPAWELPITLEEICDTPVATAKLAAQQPWWSPPGSHLGYHPATQGVLVGELVRRITGQSLGAFVQSEIAEPLGADYRLGVLPADEEGDPARVAEMVPQPQMLSLEGLDPASIMMRTTMGSPIPPQAVNGAGAPLRRTELGGTNGFSNARAMARIGSMVANGGQLDGKRFLSPETINRILEPQVDAVDSVMGKRMSWGLGWALPTSGNSYDLATDGRVAYWEGWGGSILIMDLDRKMCIAYAMNKMGASLEGDSRTKAYVKQIYQIVCDMQNAEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA02</accession>
    <name>A0A8G1RA02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_474441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519799.1">
        <property type="nucleotide sequence ID" value="XM_025662661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA02"/>
    <dbReference type="GeneID" id="37166063"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="435" mass="47444" checksum="CA0405AF13FA05D2" modified="2022-01-19" version="1">MGIPLFCESSADAPKNNPVKDPCATARSAIRRQASIRRPSRYGGSALRSATLRSPFPRPLVDEIEREANGLQRHVRSPLSNSSSADDPFDLARGLLDSDRREAGQRLLSDALRHGRPGQRLRIPRSSALPDLYNRPSPGDDTTNRPDQTHPQFTPRFAPAIAYHRTASPQARPEAARLSPFLRPDGLGSDLSISAGFPTLRRVGERSINEANRANRESAIDGLGDRQRSLSPDDDHANDAWETLLTTITPDTNLPSADSSFTSASASGTNASTVGTSTSSATSLQMSNPMESGTGTGTVQMVLDPYPEFLNPCDYSSSSDSDSDSETGISSNALFRRYRRVRQMESLRRAQHLQSTMSNHPPIPTISFAFSDSSSTSTDPDLQQMQAILDRLARREDIPEEWWAAAGLSRTLGRRLGVNDDTNDTDSVDGPLRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAI9</accession>
    <name>A0A8G1RAI9_9EURO</name>
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        <submittedName>
            <fullName evidence="5">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_189901</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519121.1">
        <property type="nucleotide sequence ID" value="XM_025654425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAI9"/>
    <dbReference type="GeneID" id="37157827"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001196">
        <property type="entry name" value="WD repeat protein (AFU_orthologue AFUA_1G12380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="77"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH61199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="375" mass="41429" checksum="0D6343A2CD0B1161" modified="2022-01-19" version="1">MAQSSHRDDFFQTTAALDEQKRKDVKSQNTNGNPIRLQSKILAVAPNPLSTGSVYVAQSGGTVRKVILETGETAALFKGPTAPVTSICFSPNGRLLFAGCWDKTVWSWDVESKEPKLRYEGHTDFVRSVISTRLQGQDVLVSGGADAQLIVFDIATGQRLAVMKGHAKGIQDLALDPVSLDSDSPELIVFSAGSDRQIRQFDLSTGSKDLTGTEALLAHDTNVHKLFFDRDADLWTASADKTSKCLVREDGWKPNLTLTHPDYVRDVVIYEQGGWVVTACRDEEVRVWNRSTGQLYHTFSGHYEEVTGLVLLGSTVVSVSIDATIRQWSLKPDELEIAVAKAKKNNEEDEEEQQNPGTMLTEEEERELAELMAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAM9</accession>
    <name>A0A8G1RAM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 11">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_446090</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="10 11">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="7 11"/>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518867.1">
        <property type="nucleotide sequence ID" value="XM_025659422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAM9"/>
    <dbReference type="GeneID" id="37162824"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="13">
        <location>
            <begin position="194"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="225"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="302"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH60945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="449" mass="49009" checksum="B3DEB3A716472338" modified="2022-01-19" version="1">MAAPAQKFKVADISLAAFGRREIELAEIEMPGLMSIRRRYGPDQPLKGARIAGCLHMTIQTAVLIETLVALGAEVTWTSCNIFSTQDHAAAAIAAAGVPVFAWKGETEEEYNWCLDQQLSAFKDGKKLNLILDDGGDLTSLVHEKYPEQLKDCYGLSEETTTGVHHLYRMLKEGKLLVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCADALRSMGARVLVTEIDPINALQAAVQGYQVTTMEEAAPQGQIFVTTTGCRDILVGRHFEVMRNDAIVCNIGHFDIEIDVAWLKANAKSVQNIKPQVDRYTMANGRHIILLAEGRLVNLGCATGHSSFVMSCSFSNQVLAQIALFKAEDAEFGKKYVEFGTTGKKPVGVYVLPKALDEQVALQHLEHVNAKLSQLTPVQAEYLGLEVTGPFKADHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAP0</accession>
    <name>A0A8G1RAP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_445666</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520159.1">
        <property type="nucleotide sequence ID" value="XM_025659321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAP0"/>
    <dbReference type="GeneID" id="37162723"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034964033" description="Mid2 domain-containing protein" evidence="7">
        <location>
            <begin position="26"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH62237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="38503" checksum="B12F21AD0CE8042B" modified="2022-01-19" version="1">MHASRIIPSTLSILALLSQFQLSIASPLEPEVSLEEATLEKRCSNPCGYYSQLCCSSSETCSTNSDGEAECVSSGSWEYYTTTYVVTETERATFTSTWSSYISATTSTGSCNAEYGETVCGSDCCGPAYVCSNNQCILGSTSIWATATATPPVRGTTLSTVTQTATTTEPFTAPVSTSGTPLVVKGSGGGLSGGAIAGIVIGTIAGVFLLLLLCACMCCRGALDSVLACLGLGGGRKRRETTYVEERRRRHHSSSGARPEQRTWFGSRPAPSTAGGGKKKESGMGALATIGIVLGAIALCLGLKRRRDRDVDEKSDYTYPSTYYSYYSSDYYTNDGSVVTDDRRTRDTRRTRRSRTRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAY4</accession>
    <name>A0A8G1RAY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_483747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519644.1">
        <property type="nucleotide sequence ID" value="XM_025663180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAY4"/>
    <dbReference type="GeneID" id="37166582"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="102" mass="10725" checksum="5527739BFD4CB2BD" modified="2022-01-19" version="1">MPDSRISDRENGINGFLVTPVTDDISGAYTRPALTKRWASADLSPATEGEPAAASSDPGLPIPRSKLLEPEPEPEPPERSARGIAVGGPPHAVPQCTPIIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDG2</accession>
    <name>A0A8G1RDG2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_444503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521103.1">
        <property type="nucleotide sequence ID" value="XM_025659027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDG2"/>
    <dbReference type="GeneID" id="37162429"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="175"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH63181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="333" mass="37718" checksum="C7D738D2C189050E" modified="2022-01-19" version="1">MVTAPPIIDFEPFYTGDAEKKAELVRQVRHACERHGFFQLINHRVPLDIQEAILQQARDLFSLPVEVKQKYSREIEPVNLGYEGLRSQKFEKEGPGDLKESYYLSQDLSPGHPYTGRFSQGSNKYPDEIRDPGSFRRTVKDYHAVMSDLGLKIFQVLAQTLDLDVNWFNGFCHDSANIIRLVRYPPQETDGQERGIGAHTDFGGLTILLQDDKGGLQVWDREASEWADAEPVPGAFVVNLGNMLMRWTNDRYISNLHRVINKSGQERYSVPYFISGNLDYVVECIPSCKAETEEAKYPPITVEEWMLARYADTYGGGQKGAGELSQDAVRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDN4</accession>
    <name>A0A8G1RDN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle subunit SRP14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Signal recognition particle 14 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_444128</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SRP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520711.1">
        <property type="nucleotide sequence ID" value="XM_025658948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDN4"/>
    <dbReference type="GeneID" id="37162350"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.10:FF:000006">
        <property type="entry name" value="Signal recognition particle 14kD protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12013">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH62789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="133" mass="14239" checksum="97D85F4F9986E247" modified="2022-01-19" version="1">MPAHLGHEEFFTSLTTLLNNTSQKTRGSVYLTQKPLLNTTTESASQPSILIRATDGNTNAPNPKTAEAKKKVSKTGSAASKVKISTVVSPDDLEAFYARYAEVCKAGMTGLKKRDRKKGKAKGKKEGGKVVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RE10</accession>
    <name>A0A8G1RE10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="9">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_444993</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="9"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519477.1">
        <property type="nucleotide sequence ID" value="XM_025659159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RE10"/>
    <dbReference type="GeneID" id="37162561"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="13">
        <location>
            <begin position="224"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH61555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="420" mass="44630" checksum="48D26412F94E6458" modified="2022-01-19" version="1">MVYGGSIKPGCSAGGKPLDLVSAFQSYGQYLTGEIDEKERFDIIRHACPGAGACGGMYTANTLATAIETLGMTVPGSSSTPAEDPRKRAECEDVGQTVKNLLKEDIRPKDVMTRQAFENAMIVVNILGGSTNAVLHLIAIADSVGIKLTIDDFQAVSDKTPFLADLKPSGKYVMHDLYKVGGTPALLKFLLKEGLIDGTGITVTGKTMKENVASWPEFSPDQPIIRPLSNPIKPTGHLQILRGSLAPGGSVGKITGKEGLRFEGIAKCYDYEDAFIEALERGEIKKGEKTVVIIRYEGPKGGPGMPEMLKPSSAIMGAGLGQDVALLTDGRFSGGSHGFLIGHVVPEAMEGGPIALVKDGDRIVIDAEQRVVDLLIAPEEMEKRRVSWRAPAPRAKKGTLSKYAKLVSDASHGCVTDGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RE68</accession>
    <name>A0A8G1RE68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiamine pyrophosphokinase</fullName>
            <ecNumber evidence="7">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_410574</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>thiamine + ATP = thiamine diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="7"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520951.1">
        <property type="nucleotide sequence ID" value="XM_025657486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RE68"/>
    <dbReference type="GeneID" id="37160888"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.320">
        <property type="entry name" value="Thiamin pyrophosphokinase, thiamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="9">
        <location>
            <begin position="223"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH63029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="328" mass="35756" checksum="6CA062F3FCCBB59A" modified="2022-01-19" version="1">MATTRLMTWDPTQFFRTEEGLPSSPYALLILNHPINERAYDVLRKNALTTVCADGGANHFYEMMKARGREDVDHPTTIIGDLDSIHPTIKSHYESHGVNVIYHHDDYSTDFTKALRYIRANTAEILSSSSSSTTTPEQTNTTTTDQQYKESDGLSILILGGLGGRVDQAFSQIHHLYSNSTIPSSSSSASSSEGNRKEGRGNGNEGALYLVSEESITFILHPGKNVIRTPGAKRADLAISTTSGEEKEYLLEENVGIIPLSGPERITTKGFQWDVESWETEIGGQISTSNHIRAEEVEVSAGGAVLFTVELAGRFKRSSSSSSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RE87</accession>
    <name>A0A8G1RE87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_444403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520981.1">
        <property type="nucleotide sequence ID" value="XM_025659008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RE87"/>
    <dbReference type="GeneID" id="37162410"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="26861" checksum="E44F8389ECB75FAF" modified="2022-01-19" version="1">MPLNPFLTIALQTAVVVTTLGFTPALSSLRPGALVFVALCTGHCISTSLGYFVRTPWASLAGGYSVMLLLHYVDIGLLTRWEFVEPSPMKSPKTLNSTWVARVRFGIWAAFNARCIGTPEQVHHIPEAVTCDRAAFLRRSAGIILLSYLGLDVLGSMGDPEVGSRFLIASRVPLFRRISQITTEEIVIRVFSGIAAGIGLLASQGGFYYLFAFTSVLARWSKPQDWPPFYGALSDAYSLRRLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1REU3</accession>
    <name>A0A8G1REU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DEUBAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_444661</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521296.1">
        <property type="nucleotide sequence ID" value="XM_025659075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1REU3"/>
    <dbReference type="GeneID" id="37162477"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028020">
        <property type="entry name" value="ASX_DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEUBAD" evidence="9">
        <location>
            <begin position="33"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="228"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="365"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH63374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="497" mass="55130" checksum="741D7D66A3536ED3" modified="2022-01-19" version="1">MPPSITTTNAKPKRNPRRAAKDPWEEEKVMTSTKSPLVDADLVGLLANPKAWNCLEESEKQEIIKLLPDSVHPDPNPPTDDDSDVKIPPPPQEFLRYSNNWREGIRQFQVELQNGFHDPEWLRQAELAMEERAAGAFDRFKEEEFEEFWGQKQKMDKTLLAGQSSQVKLKTLIDHNVVREGDVWKYSRCFSKGADRVLVEKEARIVGIKGARLSFVIPPGQRVFLPVVSSQSKQNQSHADGTKADVEAGDRQQDSDAVQTDSNVQPNTSETTEPASPRKHKCEAEHGDCKRQRSQPPEADDQQPDSDAVENDSNVQLNSSELTQPMSPKKRKCEDEHGDCKRQRSQPPEADNQAASSSEVPENQIEAAAETASPSTTAEAVSSAEVAEISTATSEKPDSAGGASDEPSVSVPEAPQESTEETEETPPADAPDANMDEILIENIQGLTSLASKIIEVDGRITDIPNGNAWKEFRAYRNNQDMGSLWEVRQAWFQRAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RFI6</accession>
    <name>A0A8G1RFI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH dehydrogenase, alpha subcomplex, subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_444765</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521402.1">
        <property type="nucleotide sequence ID" value="XM_025659103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RFI6"/>
    <dbReference type="GeneID" id="37162505"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20266">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045299">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006643">
        <property type="entry name" value="NDUA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH63480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="123" mass="14599" checksum="904F5D52F0832D03" modified="2022-01-19" version="1">MTINPTFLAQRTRSSANWGDAKHRVLKSYREWLRASPEIQTMYSLNLPVSAIRTKIRQEFEKHRYVNQLNVVDVLLYQSHAEFQETLNYWKQLSHVMKYFRPEEDPGARLPPNFISGFLEGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VG06</accession>
    <name>A0A8G1VG06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein ras-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_385375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825092">
        <property type="protein sequence ID" value="RAH51814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509736.1">
        <property type="nucleotide sequence ID" value="XM_025656592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VG06"/>
    <dbReference type="GeneID" id="37159994"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000654">
        <property type="entry name" value="Small g-protein ras2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="195"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH51814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="241" mass="26714" checksum="91FF1EAABAF7B741" modified="2022-01-19" version="1">MSGKMTLYKLVVLGDGGVGKTALTIQLCLNHFVETYDPTIEDSYRKQVVIDQQSCMLEVLDTAGQEEYTALRDQWIRDGEGFVLVYSITSRASFSRIQKFYNQIKMVKESANSGSPSGASYLGSPIHTPSGPPLPVPVMLVGNKSDKAVERAVSAQEGQALAKDLGCEFVEASAKNCINVEKAFYDVVRMLRQQRQQQQGRSQDRRTTGLGAGRDPGPEYPRSFRPDRTGSHRRPFKCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGU7</accession>
    <name>A0A8G1VGU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycolate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_454336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825089">
        <property type="protein sequence ID" value="RAH51980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509902.1">
        <property type="nucleotide sequence ID" value="XM_025661263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGU7"/>
    <dbReference type="GeneID" id="37164665"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050155">
        <property type="entry name" value="HAD-like_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434:SF1">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH51980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="233" mass="25839" checksum="C62E218625570B16" modified="2022-01-19" version="1">MPYQLVIFDFDGTLFDTYDAIEHSIQLTFQRLLPSHPPPSSSDIRPLVSTGAPPGDTFRSLHPDPTTFDESLWIPTYRELYAIHGQSRTSPYPAARGVLQALHDRNQPMAIISNKAAVAVKAALEKTDLLQFFPDSLILGHGVAGVQRKPDPSSFTDVLWPNWKALGAPDAVEAERVLMVGDTLTDILYARNIGAQVCWCRYGQGDVEECQRLQPDHTAETLEDVLKIVEGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VH13</accession>
    <name>A0A8G1VH13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_430968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510786.1">
        <property type="nucleotide sequence ID" value="XM_025658309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VH13"/>
    <dbReference type="GeneID" id="37161711"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="74"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="572" mass="63594" checksum="E0AFE2885F43ACB0" modified="2022-01-19" version="1">MTKSIECGFPSQAPHIMPQYCEFRKPLSELNGATLDLSKLVAKRFRFLVIDSLLNDQVLEIISFSALPTDGNRFATISYPWQGLTPLVPPSLGQFSVKGAESGGSISVNVLRTCCRAARQYRHRIGPCDLLWIDRLCIKQQDKEDKNWQIRHMFDIYRSCAVCLVLPGGLGRLIDPTERSTWAQRAWTLQEAIAPPIVLVVFQWKFPDLYGGRDCEPVGTIEPFNSGALSLEGLVVAVRKGLWVYSRLRRPGDPGYDVVQEELSRLRGIDCISFSEGSLSKPGSSQFEEFSDHEEDRTEIRFRMQTITSDQAYLLWLTSETSKPNDFGEVNSDKLQVALWKATWIRSSSRPVDMVFSIMGLFGVSLDPSKFHRDDRVGATLALASAALQKGSTAAWLGAYLELDPCPFMSSFPPIPNTSESGGCTNKTATGLINVEDLVNVMNIVLPARSATLDSQGYLHLKSQAFPLVRSEEGSSSSANHISAQNGAWVLDSSNKGHSRYYAITFGRRVWIVPGAEPCLIFADPIVLIIVERHSTKPDLFHRISHASVTEDFIAKWEEYEFAIGGPNKFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VH98</accession>
    <name>A0A8G1VH98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GMP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_406737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511041.1">
        <property type="nucleotide sequence ID" value="XM_025657343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VH98"/>
    <dbReference type="GeneID" id="37160745"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="247" mass="27707" checksum="B5D9E8152244C720" modified="2022-01-19" version="1">MSQSLRIAILECDTPIDPIRTKFGPYGDIFESHLKEGLRRINTNVSLQLTKINVVQPFVDYPKPEDFDAVLLTGSKHDSYKDEPWILTLTRFVQDCYLIHHKPVIGICFGHQIIARALGARVGPNVSGWEVAVESVDLTSAGKRLLGRDTLAIHMMHRDIVYEVPPGCVNLGATFICGIQGLYVPKRILCVQGHPEYNEFMVSELLKLRRGMLGEALYENAMARVGREHDGLVFAETMCRFALGILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHF5</accession>
    <name>A0A8G1VHF5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2,3-Dimethylmalate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_492904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate lyase/PEP mutase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510487.1">
        <property type="nucleotide sequence ID" value="XM_025663804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHF5"/>
    <dbReference type="GeneID" id="37167206"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000009">
        <property type="entry name" value="2-methylisocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF15">
        <property type="entry name" value="PHOSPHONOMUTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00061405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="303" mass="32187" checksum="119F9C69450C5231" modified="2022-01-19" version="1">MPMVTAATTLRRALENPDSFIVAPGVYDGLSARVALSAGFDALYMTGAGTAASVHGQADLGICTLNDMRANAEMISNISPSTPVIADADTGYGGPIMVARTTEQYSRSGVAAFHLEDQVQTKRCGHLAGKILVDRDTYVTRIRAAVQARQRIGSDIVVIARTDSLQTHGYEESVARLRAARDAGADVGFLEGITSREMARQVIQDLAGWPLLLNMVEHGATPSISAAEAKEMGFRIIIFPFAALGPAVAAMREAMEKLKRDGIPGLDKEMTPQMLFRVCGLDESMKVDAQAGGAAFDGGVDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHM0</accession>
    <name>A0A8G1VHM0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-1,3-mannosyltransferase CMT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_453018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511418.1">
        <property type="nucleotide sequence ID" value="XM_025660971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHM0"/>
    <dbReference type="GeneID" id="37164373"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF5">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE CMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="425" mass="48466" checksum="B8A09C2997E6B8C8" modified="2022-01-19" version="1">MTFGRPKPWRRLLLILGASTILFLLLSDEKPRWLATRAHSSCTGFDLASVSEDLHSRMKAESDYTPVEIHQFVCGIINHNMTATAHLECPATISQRYHTLIPVDGKHPKIQYFFALNLYQVIHIILPLMGSILEAIRYLGPEHCALSIVEGRSTDGTYEILSRLKPELDAMGVRYYFSRSPINPLGPGENRIKDLSELRNMALEPLITGARQNGGPFGHDPMIIFINDIGICAEDILELVYQQKVQDATMTCAFDWREEGVIHDVWVSRDLSGDLFFDISSDGRIWDSHNLFSHHGPTRERFAKHLPVQVYSCWGGMVTLDSGPFIDGHVEFRYSEEDECYMGEPTLLAQDLWRLGLGKVLAIPTVNVAYEYRWSLRAKEEKGYVHTILEGRYSPHDELVHWQKEPPKQIKCMPAWDDQSWVDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHZ4</accession>
    <name>A0A8G1VHZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_428511</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511836.1">
        <property type="nucleotide sequence ID" value="XM_025658208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHZ4"/>
    <dbReference type="GeneID" id="37161610"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH53914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="507" mass="55965" checksum="275744771E6144D2" modified="2022-01-19" version="1">MAAAAIKESVSSLIHGQSEPALREPSPEEFEQLKKKYTDAGQGQVFAFVDELKPAEKTQLFHQLNDFDPVRINELAEKALNPPKAEQGPVSLEPLPEVATASILDSDPKDIQKWYDEGLHLVAGNKVAVVLMAGGQGTRLGSSAPKGCFDIGLPSHKSLFQIQAERIAKLQLLAKKSSGKDAVIPWYVMTSGPTRKPTEEFFQQHNYFGLDKSNVVIFEQGVLPCISNEGKILMESKSKAAVAPDGNGGIYLALLTSGVREDMRKRGIQHIHTYCVDNCLVKVADPVFIGFAASKDVDIATKVVRKRNATESVGLILQRNGKPDVVEYSEIDQETAEAKDPKQPDVLKFRAANIVNHYYSFRFFESIESWSHKLPHHVARKKIPCIKPETGEAFKPEKPNGIKLEQFVFDVFPMTPLEKFASIEVRREDEFSPLKNARGTGEDDPDTSKADIMKQGQRWIEKAGGVVVTEGEAVGVEVSPLISYGGEGLEFLKDRELKAPAVVEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK22</accession>
    <name>A0A8G1VK22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_381810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511225.1">
        <property type="nucleotide sequence ID" value="XM_025656439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK22"/>
    <dbReference type="GeneID" id="37159841"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="275" mass="31222" checksum="7A7C69F0FADDFD55" modified="2022-01-19" version="1">MSPENGSPMVLLCWGESSHCSILPVPIANSEDDVETWREIHRAWYARRGYWRKRLPGYSVTRVDAVKISLLGSKKASKGRENCEYIGMYTGRDIPTERNILQQTIDNCVPISDCFYDRRTGTVECGYGCNCFSCLPYVNNAGECPEEKYCTARRNIVHLDTLHLMKHAFSNPDLAALNDFLKKENLLYSHRDVLGLTETWNSWHCPALREIEFRGIVVSEGWALDKHHITLPLLVAILLGVVVAARFLFGWDTAWTVGAFFVALISLLLCISYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL82</accession>
    <name>A0A8G1VL82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_403849</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512365.1">
        <property type="nucleotide sequence ID" value="XM_025657249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL82"/>
    <dbReference type="GeneID" id="37160651"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="620"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH54443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="762" mass="84586" checksum="55AA8F6082CF74F4" modified="2022-01-19" version="1">MDRDSVKRGSNTPEPPRSKKRAKYTQVACNECKRRKLKCSGEPVCSRCARDNVRCVYAPNAHVVASTASPSVEDPVKDERYDRLSTRLQTVDQQIASLQREMRAMAARLRHLESTSVTTPANNTSIPTSMSTVSSASVNTGLQRILNRPKSPSYVGPTSAEFGLTARQKASEDSDGDADETDSAAAPSPAPAQDSEALSGDPLRCMGLTETLRLVTVYENTVGLIYPCVDLDSVRAYVVEYFRDERDGPNETRSPETEDQDWFFARDVEVLKIIVATALLAESHGRSERAAWLADSVEDQFASRYKVPEVDMKELLILTLVSIFHSYRDDEVIAWRTIGSAVRGAVQLGLHCQETWLRTGGVFPGELHRTWASRLFWCMYVLDRKWSFGTGLPFAIQDSDMDTNLPEPGTSTPYLTCMISYARLSSKIWGLVVGWRTRPRAATADYCSYLDFQVQQWIQSIPPELRFDPSQRSSSTAPNAQTDSMMMLQVLLALQANQLRILVYRQYLLSTESIEESVPSASIAVETAKSTVHMLDFFSRVSGIYFQRPEPFNYFLISALAALFLAVLHAPSRFSQVCRPEFYKAVDMVRRSSTRARTSRRLQKIIRNLKLIRSNLGAKSPRQAGAQLQHQHQHPHQTPKRQPSISTTMSAAVPFTPVDTPYPPHPQHQLSGFNPVHQQSVSVSAYWPATAAGGNAAVDDQQESCEDLTSFFEMAGGFYFDPRAQAEVPEAGNGNVTGPDGAGIEALNAEDEALTRVMAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLN1</accession>
    <name>A0A8G1VLN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_448869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515693.1">
        <property type="nucleotide sequence ID" value="XM_025660042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLN1"/>
    <dbReference type="GeneID" id="37163444"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034953930" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12524" checksum="A599EB5C76EE941F" modified="2022-01-19" version="1" fragment="single">MGNRRRPLHLLQLLLLLLLLLTVISTRPRVPGRIHAQAKRYLKRQQYGGVQPISVTIKLYWPSSKTLYTVVQVMSYCHQAAHFFFLDFFKRKFGSDKGGPSRLVVEGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLN2</accession>
    <name>A0A8G1VLN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_374671</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514539.1">
        <property type="nucleotide sequence ID" value="XM_025656139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLN2"/>
    <dbReference type="GeneID" id="37159541"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000539">
        <property type="entry name" value="Ring finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="245"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="153"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH56617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="439" mass="48664" checksum="F8A4417956B30C55" modified="2022-01-19" version="1">MSSTTTGSSSSATSTDRNGNNNSSSPTSSPLLFFVALGFGVVFTNLWIIVGVKYCFRYNQRNRQLRSEETGEPIDLVAMPRTHRRRREKKLMTMDDVNERFPLTKYKAWRSSRENEGLSTAGGISAPNSRSQSLKDENYMISASLGAPSSMLASPLKSHQRVDSNTSQTSTPLEDLETTLPHSKEKSQRYPEANIGVNDNANISTPEQPRNHALNHVIVEDVGDLEDHIRTAVPADFLANPGDTCAICLDTIEDEDDIRGLTCGHAFHASCVDPWLTSRRACCPLCKADYYIPKPRAETSELPPSSERQGRRGMTRMTPINPPQAVFIGGRVNFLRSSSGFPEQHAQRRPLTHRAGFSRLRLWRAPQSNHQPTSPVPDTSSAQPGRRDQRLGIFTASYFPLNFGFRGNRASRGVANRNADVRYSDNNRTLGELEAGPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLT7</accession>
    <name>A0A8G1VLT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosome-releasing factor 2, mitochondrial</fullName>
            <shortName evidence="7">RRF2mt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Elongation factor G 2, mitochondrial</fullName>
            <shortName evidence="7">EF-G2mt</shortName>
            <shortName evidence="7">mEF-G 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MEF2</name>
        <name evidence="9" type="ORF">BO85DRAFT_41029</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLT7"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04092">
        <property type="entry name" value="mtEFG2_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000106">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000007">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001636">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03059">
        <property type="entry name" value="mEF_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030851">
        <property type="entry name" value="EFG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="63"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="72"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="158"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH56782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="917" mass="99356" checksum="D6E87223A621EF99" modified="2022-01-19" version="1">MVTALFLRASHQTVRPTGLRQCQVATSRLGCNASLIPGAKKGQFPRIQLLSSSASKLQADTLDRTRNIGIIAHIDAGKTTTTERMLYYSGFTRRLGDVDEGSTVTDFLPAERARGITIQSAAITFHWPPQAAGNQIAAAQDNPKTPRSAISHTVNLIDTPGHADFTFEVMRSLRILDGAVCILDGVAGVEAQTERVWHQASTYRIPRIVYINKLDRDGAAFGRTVREISSRLAGYPAVCQIPWFEGGNGRFVGVGDAINLQGLRWQDGDGKAVKMFNLQELDGEEPGLAQEIRRARTALVELLSEHDETMIERFFEHDEDHLAVPPNDIIDSLRRCLLQEQGRKIIPTFAGASFRNIGVQPLLDAVTNLLPSPLETPDPEVSIGGVRGGLRSLLSGDLLVKQSEKAATSKGKQKKKKSVTQAESQNAIEKLQSCALAFKVVNDAKRGVLVYVRVYSGSLDRNSAIFNTNLNITERAPRLLKMYANDAVEVDSIPEGHIGVVAGLKHARTGDTLVSYAGNKLTPPEPLDTLQLRPIQVPPPVFFASIEPHSLSEEKKIHECLALLLREDPSLHVTVDEDSGQTLLSGMGELHLEIARDRLINDLKAKATMGRIEIGYRECPLGESPVTSKIFDKEIAGRKGKAGCTAVVEPFDPDNAPPVPEDALSVETKEGNQIIILAPELQVETNRKGIEESPILPAGLDMHSFRASLQNGCLAALARGPQFAFPMHHTRVTLTINQTEHLFGTDTTPAALSSAARLATSAALRDLLSSGPGTSLMEPVMNVIISIDEASLGAVVHDISSSRGGHIVSLDEEIPLTSTDLSASPQPVEDLPPIDPKKVYAPADPFESGSVGASLPDTANRPRTITAKVPLKEMVGYLKHLRSLSAGRGTFVMSVDRFEKMSTPRQKAVLTELRGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM34</accession>
    <name>A0A8G1VM34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_449826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515034.1">
        <property type="nucleotide sequence ID" value="XM_025660244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VM34"/>
    <dbReference type="GeneID" id="37163646"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="276" mass="31780" checksum="5E33F545816E2BF9" modified="2022-01-19" version="1">MASIVTGPLGRFRKNGSHKRLHERWGDVGITVPTEGSWNQRDNPHRSSDRRRPAYEVLSRGQDSPVEDHHESTQQSTQPSSFSVKALNPRRLSMRISSRSKPTTDYPKENTTPTDRQTKAERRVSQFTYRPIHQDYPTEMAEKASRQSQHSPRFRYIPTAPQYAEELGLPTSRRWSSQRHSVQSSCPSEGTRRSHRRYPDAAEDCYEDEYYEERRERYERPLSTRRDRSSVDYYSAAASRRGSPALGRSGVATEKRGRSGRNLTTAMVPDADDIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM42</accession>
    <name>A0A8G1VM42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_477907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515332.1">
        <property type="nucleotide sequence ID" value="XM_025662860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VM42"/>
    <dbReference type="GeneID" id="37166262"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034840077" evidence="1">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="104" mass="10962" checksum="6DEEAA65019A5EAD" modified="2022-01-19" version="1">MKLLSTLVASTLALAVSVQATDCTEGMKYCKSVLEDIDYTKYSTLIPQAIAAAGFNQDALPPPLMLDRPSFLFACGSGGSITAERECTFGCNNAGAGHNDYCTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM70</accession>
    <name>A0A8G1VM70_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stromal membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_438603</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515407.1">
        <property type="nucleotide sequence ID" value="XM_025658679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VM70"/>
    <dbReference type="GeneID" id="37162081"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000010">
        <property type="entry name" value="Stromal membrane-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="14"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH57485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="576" mass="59532" checksum="519207B97BE34E88" modified="2022-01-19" version="1">MSRRATPSQAAQNQQIIKSLLKLEQNKICADCKRNKHPRWASWNLGIFICIRCSGIHRGMGTHISRVKSVDLDSWTDEQLQSVVRWGNARANKYWEAKLAPGHVPSEAKIENFIRTKYESKRWVMDGPMPDPKTLDIGDDDVPLAVVQEKAKIERSASQRVAASSQPAVHRQQQSIDLFADDPIAPPARPSTTEPTPRAPPKQPQSAPAPKPAARPGDSLLGLDFFGSAQPAPTSRPASTASTPTGSTGMSRPDLKQSILSLYSKPPPATTQHERTSSFGDLASPAPGSSASNMGGLTDAFSGLSIPSSTSPPAPKPAEKPSPFANLTNFASMKSTPAAPKVSSPTASVGSGGGSLFDSLTSPTVPPPKPQSRTTSISSNGFDAGFTSFASPPPPKPNPPKSPLSDDLFGLSSPAPAAPAAVSPPAFTSTSPQQELKSAFNLNPAPAPAPASRPSVASTASVASVLPPTAIDPWGGNAWSTPDPAPAAPAAPAASASMMKVPDTLTANDIGAGWGAPALSASSKSAPTVAADEDFGGWTSAAPISSTTTTTTTTNAPSKPAGGFGGADDLFSNVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMC9</accession>
    <name>A0A8G1VMC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS monosaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_470394</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513490.1">
        <property type="nucleotide sequence ID" value="XM_025662395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMC9"/>
    <dbReference type="GeneID" id="37165797"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000119">
        <property type="entry name" value="MFS monosaccharide transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="127"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="610"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH55568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="678" mass="74272" checksum="1E8070E8BA08BB9A" modified="2022-01-19" version="1">MESLMGTAGNMVVASVFAGSPTTPSSGDLTEQLANAEDYLRIPLRSSEDRESSGRVESSVRTEKQNRVHYPSQLVIGEDDFEKIEIPCPPPRKIPRAERLLAVIMSPNNRQSAHLHGLVGKPLLYFTSVFVSLGVFLFGYDQGVMSGIITGWYFKDYFNQPSRAAIGTVVAILEVGAFISSLLVGRLGDLIGRRKTILYGSIVFFIGGALQAFATGLPMMMAGRIVAGLGVGALSTIVPVYQSEISPPHNRGKLACIEFTGNISGYAASVWVDYFCSFIESNYSWRLPLLFQCVMGALLGVGSLIICESPRWLLDNDHDEEGMVVIANLYGSGDLHSDKARQEYREIKMNVLLQRQEGERSYADMFRRYYKRVLIAMSAQALAQLNGINVISYYAPLVFESAGWAGRDAILMTGINAISYLASTVPPWYLVDRWGRRPILLSGAVAMIVSLSLISYFIYIDVVATPTLTVIFVMIYNAAFGASWGPIPWLYPPEILPLSIRAKGASLSTATNWAFNWLVGEVTPVLQAAIKWRLYLVHAFFCACSFVLVYFLYPETSGVRLEDMNLLFGDATTAMPTPATQGERGSLMSAGSPVPSLDIRRQYGRLGADSAIPGLDIDPPNVSSSTGSKPGRTGFREDTSSRPEGFGGWISNMITRHKGSESTGQAGQYRRLGQEENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMT4</accession>
    <name>A0A8G1VMT4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">homocitrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_449190</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="5"/>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516007.1">
        <property type="nucleotide sequence ID" value="XM_025660110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMT4"/>
    <dbReference type="GeneID" id="37163512"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000002">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="60"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH58085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="463" mass="50841" checksum="CF0B973C4625332D" modified="2022-01-19" version="1">MCPGADHEPNGQANAANGRNGEHPGFTAVETRQNPHPSVSRNPYGHNVGVTDFLSNVSRFQIIESTLREGEQFANAFFDTEKKIEIAKALDEFGVDYIELTSPCASEQSRKDCEAICKLGLKAKILTHIRCHMDDARIAVETGVDGVDVVIGTSSYLREHSHGKDMTYIKNTAIEVIEFVKSKGIEIRFSSEDSFRSDLVDLLSIYSAVDKVGVNRVGIADTVGCASPRQVYELVRVLRGVVSCDIETHFHNDTGCAIANAYCALEAGATHIDTSVLGIGERNGITPLGGLMARMMVADPEYVKGKYRLEKLKDIEDLVAEAVEVNIPFNNYITGFCAFTHKAGIHAKAILNNPSTYEIINPADFGMSRYVHFASRLTGWNAIKSRAQQLKIEMTDDQYKECTAKIKALADIRPIAVDDADSIIRAYYRNLKLGENKPLLDLTADEQAQFAAKEKELAAQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNF8</accession>
    <name>A0A8G1VNF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bis(5'-adenosyl)-triphosphatase</fullName>
            <ecNumber evidence="7">3.6.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_436781</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13893"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.29" evidence="7"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517761.1">
        <property type="nucleotide sequence ID" value="XM_025658584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNF8"/>
    <dbReference type="GeneID" id="37161986"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000011">
        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="8">
        <location>
            <begin position="14"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="6">
        <location>
            <begin position="106"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="101"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for induction of apoptosis" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH59839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="190" mass="21105" checksum="B6B3142221B90DDE" modified="2022-01-19" version="1">MSIPTTITQILKAGPIHFGPFTVTTQVFHLTPYSYALVNLKPILPGHVLISPRRVVPRVTDLTPTETSDLFLTVRRVARMIERVYGASSLNIAIQDGADAGQSVPHVHAHVIPRKRGDLDSRGGMDAVYEMLDGEEGDLRDVFAKDGEEGGEGRRRFPRVDNEERVARSAEEMEGEAWRLAGEMEKEDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNK9</accession>
    <name>A0A8G1VNK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pre-mRNA-splicing factor cwc2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO85DRAFT_450207</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514735.1">
        <property type="nucleotide sequence ID" value="XM_025660322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNK9"/>
    <dbReference type="GeneID" id="37163724"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000249">
        <property type="entry name" value="Pre-mRNA-splicing factor CWC2, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="193"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RAH56813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="415" mass="45895" checksum="8849AA33D109A053" modified="2022-01-19" version="1">MAEATPPTETVTPPTEEVVEDQQQLQQQQQQQQETETTEESTALTTTADGTVEPTKKTKKIIRRKRRPARPQVDPATIKSEPPPQVGTIFNIWYNKWSGGDRENSYLSKTAAPSRCNITRDSGYTRADKVPGSYFCLFFARGICPRGAECEYLHRLPTLHDIFNPNVDCFGRDKFSDYRDDMGGVGSFMRQNRTLYVGRIHVTDSIEEVVARNFQEWGQIDRIRVLTSRGVAFVTYTNEANAQFAKEAMAHQSLDHNEILNVRWATVDPNPLAQKREARRLEEQAAEAVRRALPAEFVAELEGRDPEAKKRKKIEGSYGLQGYEPPDEVWFSRAKELEDANAIAQLEAPEQPLMIEGASETAAGGAAPQEEQAGGIFSSSAVAALKGLAGGSVTTQQAPKAAGPLVAYGSDDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPX8</accession>
    <name>A0A8G1VPX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Synaptobrevin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_446439</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519203.1">
        <property type="nucleotide sequence ID" value="XM_025659505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPX8"/>
    <dbReference type="GeneID" id="37162907"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15860">
        <property type="entry name" value="SNARE_USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="102"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH61281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="345" mass="38117" checksum="6B808DA8AA840999" modified="2022-01-19" version="1">MTLTAYSSYPDSPDLAALNLSRLVARLEHNLLSSSADLKPLRQSEYQRMRVGANIDYARTNLQTLERTLPQIKPTDRRNDLQSDLARQRQVLKQLQNVLDEISSSQAEPQSDDDEEEDDSLDGEDLLGTPDEGSTTDEQLEHEEKDRDIVPHDKEPTTTTTTTTASATNTPSAPPMTTEPPSQTAEATPAPTQEQPSTLRNRSHAPTTIPSTATASATGSSLQKNPPSPQQSSDSRLHATEETLSSHRAEQEDLTSSMLALATQLKTSAQTFHSSLEAEKSVLARAVDGIDRTAGNMKVAEQRMGMLRRMTEGKGWWGRMMLYAWIFGMWLVAILIVFLGPKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQD2</accession>
    <name>A0A8G1VQD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Asparagine synthase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_412694</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519846.1">
        <property type="nucleotide sequence ID" value="XM_025657578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQD2"/>
    <dbReference type="GeneID" id="37160980"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03766">
        <property type="entry name" value="Gn_AT_II_novel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH61924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="595" mass="65074" checksum="C4FA0FDABC64D36C" modified="2022-01-19" version="1">MCGIFFSLSASGAVLPNEETCCLLRNRGPDNYHVHSVEQKIKPRSSNDEPIAIQLTFVSTVLSMRGGCLVPQPLVDPTTQSVLCYNGDAWKISGEPIRGNDAELIFKLLLQAVNHHSKVTSSADSSKSAVQGVLDVISSISGPFAFVFYDAINSKLFFTRDSLGRRSLLQGVDESGAFKLCSLCDGTSSTHFSEVETDGVYVVDLEHAILQDNSIATKSAGTPSFDASCIQTLFWEHNTSDLPLRPRNPVPPMNKSIPEGEAPSLTVETTAVKELEHKLRQSLAMRIQNVREPPTASSESNVKVAVLFSGGLDCTLLARLSHEILPKEEVIDLLNVAFENPRVAAAAKGKGEATGSVYESCPDRITGRAAFAELQRVCPDRNWRFVAVDVPYQETLAHRETVKRLMRPHNTEMDLSIACALYFASRGQGLAFDSRQIDAQPMQYATSARVLLSGLGADELFAGYSRHGAAFSRDGFAGLIDEINLDVSRLGKRNLGRDNRVIAHWGREARFPFLDEEFVSWVVQLPVWEKCGFGTPSPPADSPEAGLDSEKKALRLVALRLGMTNVAREKKRAIQFGSRTAKMEKSKVKGTDALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQL5</accession>
    <name>A0A8G1VQL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_435212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518799.1">
        <property type="nucleotide sequence ID" value="XM_025658506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQL5"/>
    <dbReference type="GeneID" id="37161908"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3 C-terminal" evidence="4">
        <location>
            <begin position="467"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="134"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="295"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="900"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="686"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="772"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="900"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="935"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="959"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="982"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH60877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1020" mass="111851" checksum="C1D75BFA4E0420BA" modified="2022-01-19" version="1">MTSAPRSSSSSTRSQSSKSVVPEKQINQIEKSVTHLLVATKQLLETLTQWSRRQASENEVSDVYVRLGYEFNLACRAFNAIGVDTSDLGPVPDLLRTILEDTLSQDASPQSLERYLPRVRDIIINLLHGLKKKQARLRARQQKEESRPLPGRHTSASSATSAQAALNQAYEDTASTVTSPKRSTRRFGSNGSMEDPSMARASSAASADVRGASYSERDASRREAQNILSQGSQPESGATPKGSVTSTNAPPYPTPPPPPAPKQDDALGALQRSGELERRASRRFSAYQIQKHLGTSSSGVPVLPTQNSPIPNRGRDVRESLNAVRLRGSVHGRQRSTNRLQDAKVASQAPSSVPSIEEERPKSRVGSPAELPAEGATAAKDKSVERPGSGPADHPAIGRQPDLPRPSEEPSLAEAFEPVKDAAPTAAARPGTPKSERQEPAVSASTPPQSVQYSPEQQSPGKELTLFLQYRSKIKKYVLPEGYTGLTIGRLQLAFIEKFAWNTHNNGVDLPEIYIQDPVSGVRHELEDLADVKDRSVLVLNVDILDEVKKHFDDEFGGVRRMIEGVKGALEGQESMMQRVSDRQLEAAKEMARLAAAPPVPVAATAKTGDTRKGPIAGSDSQIAELQSLRRDLAVLRQTYSNFTADIASSMSAIRTKAGGLKTAAADVTVPSFEGDAGRVRVNSGKKELAEESERLVARVDDLQDLVEDLRKDVVTRGVRPLPRQLESVSKDISAVTKEIKKMQDFLKREKPVWTKIWEKELQQVCEERDQLTMQEDLAADLQDDLEKAAQTFALVEQATKQQAMQNNTGGPTLRNTSRNVVIDPAVDPMKAKDSVLGEVRALQPNHESRLEAIERAEKARQKELETRRIGLFQKELGAFVEEGKLKKSGGVEEAERLRRAKDDRIRKEVWERQQARAAEMEKAEAEAAAAQAEQAEEPAEDAEAAEAEPDADVAEEANAEKEDSGKEEEVTMVKGKSPVPEDSDEAEEEQRETFLDAEEHEETDKEATTAHEQKPDHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQM3</accession>
    <name>A0A8G1VQM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acid phosphatase/Vanadium-dependent haloperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_364699</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518829.1">
        <property type="nucleotide sequence ID" value="XM_025655708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQM3"/>
    <dbReference type="GeneID" id="37159110"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000042">
        <property type="entry name" value="PAP2 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF154">
        <property type="entry name" value="PAP2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G09730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="101"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH60907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="352" mass="38876" checksum="36892A17B0D01D11" modified="2022-01-19" version="1">MPPSKSEDTPPPAPHRHQLSYQNFSKRLILSYIFDWILIIGVALIGYGFNQTTPNHRPFSLTDPSISFPHREKETVSTGVLAVVAVVAPAVIIVLLWEWHAGWMGLGVALAGTFMATEGLKDLYGKPRPDMLARCDPDLSAVNEYAVSGLGGRIAGAPTMVTWEICRNKGDEMLKVDGFASFPSGHSSMSFAGLMYLALWLSAKFSIGFPFLAYSPLSQDLQRQDRGKIRNQGAAPPVYMLIVALVPIAVAFFISASRWFDYRHHGFDIIFGSVMGMVFAWIGFRLYQLPIIRGAGWSWGARSRKHAFFMGVGQPSHVSADNWVMMSDKRDAAESSPHNVDLESGRPGPDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR63</accession>
    <name>A0A8G1VR63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_409987</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520671.1">
        <property type="nucleotide sequence ID" value="XM_025657458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR63"/>
    <dbReference type="GeneID" id="37160860"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="6">
        <location>
            <begin position="60"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="4">
        <location>
            <begin position="60"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="503"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH62749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="540" mass="58922" checksum="51395C88B51CEC18" modified="2022-01-19" version="1">MANTESGDPPLNAGQALNGQTTAGRRESFSSQNSQTAKEFIESQIRLEADAREVLPYSFDTCTQDLGPLRQSLFACLTCNPSTSEESYTPAAVCYSCSISCHGEHDLVELFNKRNFVCDCGTTRMPATSPCTLRNDPKTGAKGVHSEQPHQGNKYNHNFQNKFCGCGEDYDPHKERGTMFQCLGLGTVETGGCGEDWWHPECLIGLPRDWYKGAKKDGATDGEAADDDEEEETPLPPGFPAEEDFAIFLCYKCVDSNPWVKRYAGTPGFLPPVYKEGGLAKPTEEDTKPITTEQTPQATEPEQPSNPKKRKADDSADEESDPAPKRPKEEPTEDPKPEKNDTTTTTTEVKLDTSQDTDKTTTTTTEPSPPKHTHLPTHPPTRTFSLFLKDDFRDHFCRCRDCYPHLASHPQLREEEETYEPPMSEDGDGEGPNGGGSTGTGSLLDRGEAALSNIDRVRAIEGAMVYNHLRDKVKEFLKPFAETGKAVSAEDIKSYFEKLRGDEQSIRDAASSAAGGGGGGGDDDGGDAGEGGGRREQSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR79</accession>
    <name>A0A8G1VR79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endo-chitosanase</fullName>
            <ecNumber evidence="11">3.2.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_500937</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Chitosanase catalyzing the endo-type cleavage of chitosan, the deacylated form of chitin. Chitosanase may be crucial in the degradation of the deacetylated portion of chitin in the fungal cell wall. Chitoolisaccharides produced by the hydrolysis of partially N-acetylated chitosan are known to have many biological activities, including antibacterial activity, immune-enhancing effects, and elicitor activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endohydrolysis of beta-(1-&gt;4)-linkages between D-glucosamine residues in a partly acetylated chitosan.</text>
            <dbReference type="EC" id="3.2.1.132"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 75 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.132" evidence="11"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519547.1">
        <property type="nucleotide sequence ID" value="XM_025664143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR79"/>
    <dbReference type="GeneID" id="37167545"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016977">
        <property type="term" value="F:chitosanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009939">
        <property type="entry name" value="Chitosanase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061:SF4">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07335">
        <property type="entry name" value="Glyco_hydro_75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034787776" description="Endo-chitosanase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="301"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="309"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH61625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="351" mass="36843" checksum="B2F75AEEB5FB4E0F" modified="2022-01-19" version="1">MTFKTTAGLALLALAGSVKAQSVDGSKYNSPTNGPPASYFAAATTLPVAALQSAAAKASSVPSKATYPVNTDKNSPKSTIHSDWVKFNQGAALSWVADMDVDCDGIDYKCKGNGDGLPETNWGALSAYEVPWIVIPDQFLTVNEDLLPGNNIAAVICNGKMYYGILGDSNGDDPEVTGEASWLMARTCFPDDDLNGAEGHAEADVTYIVFTGDDAVLPSSALDKNYITNFSTLRSMGDKLVGALASNLGLSNASVPSQTTLATSAASTPSPSGSTATCSWEGHCEGAICSTEDDCSDDLVCDSGKCSSADDEDEDDDDEDDVDDDEDDENDDDDDDDEEDDDDDEDDEADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRM7</accession>
    <name>A0A8G1VRM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_494681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521003.1">
        <property type="nucleotide sequence ID" value="XM_025663871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRM7"/>
    <dbReference type="GeneID" id="37167273"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24288" checksum="B3BF8DB0B9A5F920" modified="2022-01-19" version="1">MSPTFTPVNNTPVHKNSTVPKTPTKKTNVAMTPQTPTPTSTTNSKKRLTPSSPTSPNNKRTKPRTPLPPIPTTLASASASDLLILRLRDESSTPWTAINQAWTDLTGISVGGSTLRARYNTMKKNFVVVDPGDEAKILQAKKDVEGRLEMEKWRLIAEEVGKVGGGTYPGECLRKYVREMEKGMKGGIAAAAAAPAAANGGGDHGDDEGEEEDVDDDDVKMEVEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRR8</accession>
    <name>A0A8G1VRR8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_447895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH60038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517960.1">
        <property type="nucleotide sequence ID" value="XM_025659807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRR8"/>
    <dbReference type="GeneID" id="37163209"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH60038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="143" mass="15970" checksum="D53F3A9D4778CE05" modified="2022-01-19" version="1">MASVPSVQCFGKKKTATAVAHCKQGKGMIRVNGQPLSLVQPEILRFKVYEPLLIVGADKFAGVDIRVRVSGGGHTSQVYAIRQAIAKSIVAYYQKYVDEHSKNQLKQALVQYDRTLLVADNRRTEPKKFGGRGARARYQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VS52</accession>
    <name>A0A8G1VS52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_473270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520464.1">
        <property type="nucleotide sequence ID" value="XM_025662613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VS52"/>
    <dbReference type="GeneID" id="37166015"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="128" mass="14064" checksum="A259691A121E4E60" modified="2022-01-19" version="1">MRKEGLIKSSTEDGTRSRFVIAARSIPPEAPMTIVEGADPLQSLLLVLTQSLTKCLLKSGLLVVLQWRKQAGIYPEACTHEAYIQPVDAATELITALAPCTYSTGPVHGTAVPFENWFLYRLKTIHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSH7</accession>
    <name>A0A8G1VSH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Patatin-like serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_435157</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518740.1">
        <property type="nucleotide sequence ID" value="XM_025658504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSH7"/>
    <dbReference type="GeneID" id="37161906"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07229">
        <property type="entry name" value="Pat_TGL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF44">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="12">
        <location>
            <begin position="193"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH60818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="604" mass="68826" checksum="6FE3D4689EA641A4" modified="2022-01-19" version="1">MGSWTTICRIFFAVLNMILDVAFFWKEVANAALHLKRLLSWWRSKSPRKRLQHVLRTASTFEEWEEAAFELDELLSMDLWRQNPTSRHYDYRLILGRLEALMSAREDEDILTLANLLRSGLLRNLGNITSPKMFLHAYAGTKLLIDDYITQVALSIQQVTALQTAPIHDSGFSSQAKLELLHDTRQAFGRTTLLLQGGSMFGLCHLGVVKALHLRGLLPRIITGTGMGALIAALVGIHSEDELLTFLDSGAIDLSAFDRRRRMKRPEEESWWLPTNLGDSWLGTLLRRVNRFIQKGYFLDAEVLEECVRANLGDLTFEEAYARSKRILNITVATSNKNATPNLLNYLTAPNVLIWSAAVASNASNNSLYQPVTIYCKDETGSIVPWPHSRDATFYQSWRQGQYKEEESPLARIAELFNVNHFIVSQARPYLIPFLRSDSNLLDRRPTDQWSITQALMRLFTAELHHRLGQLDYMGLLPATLARLLIEETIPGPHITLVPDVSLLDLPKLFQNPSKDRLAYWSLKGERGVWPAVSALKVRCVIEIEIDKGYQVVRRRQPSENAPSTPRRMPNEGLPRRRRGYSIDYGRDMLNFSGSLDCQDDSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSK0</accession>
    <name>A0A8G1VSK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_15151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520942.1">
        <property type="nucleotide sequence ID" value="XM_025654149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSK0"/>
    <dbReference type="GeneID" id="37157551"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH63020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="711" mass="78566" checksum="7572E9747F95F786" modified="2022-01-19" version="1">MNKDLSDASTGRGTLKGFYSYKNTFDKDSVWLDIPKHVIFVDNSDPYAEDFEAALGESEAAILAANSHARAWSAQRTSSTDGETHGLETLSTVAANDRLSYPPLSIDQQSIPSTDHSVPFNNVPSTASSDTPSQVRGVIAPQISPSLSISSTNTHNNNINFLLNPSQSRSPPVDPNLQHPPERRSSSLTARPALPRTTSAESKSDAPAETDHEVAYLLRHFSEAPGLWMDLFDLGTYFASSVPVRALRNPLLKYAACAYAAKQLGRIKGTQVSTGGVYTRHLANNVDWSWSGAKYYEKAIQLLMKELQPDKGPPPLSTPEAFGQWQAAELCEDQENPRKRRRRYSDSRFSKGVHSDEILAATAILSVYEFLDATGPAWNRHLSGVKSLLDVAEVGMMPVEQRHSPGGTALQQTKVSGLSKARKATFWNFARQDYLAAFINESQTRLNTDDLVLWTEAGLQIDNMGFVRSSNATAMGYPDDEEPIKEDLVSNGLVWILSKIVNFINAGDNVQLGHPGSIGAGPLGLSQQVLLERWYRLEAELDAWYNGLPETFQPCARVELSKLPQNRDNPKFDAGSLSEVWYSLPLCSSAMQHYHMARILLLINKPHESTSRRSTIADRLNSYRSIESDIRFHSREIVGIALACPTGAVRINSLQPLFVSGQCLTEPGERRTVLALLHGIETELGWATEYRVNQLLREWGWNEDSANASVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VTN1</accession>
    <name>A0A8G1VTN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_389170</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519910.1">
        <property type="nucleotide sequence ID" value="XM_025656736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VTN1"/>
    <dbReference type="GeneID" id="37160138"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000318">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="643"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="673"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="701"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="732"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="761"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="831"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="869"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="912"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="945"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="974"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1008"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="607"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH61988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1035" mass="115730" checksum="CD94E0540594888E" modified="2022-01-19" version="1">MTIFIHTLAATPMTSAGIFLALTLTIYSNYQRYLHPLAKYPGPFLACLTDLWQVYQFLTLKQPYNLTELHAKYGPIVRYGPDKLSITNEGAIHAIYQKGGRGMPKTEFYDAYGAAHPNVFGMRDEEQHSIRRRHMSHGFSMSYVKEMEQYMDLNIRILRDKIREHSAQNRIFDLKKVLHYYVIDVLGELAFSQSFGVQETDDETRVPPVIEHSLLAAVTGAWPAMTATLKKYLPLVSYKPLQQLFAGRKACADLASKCVQRRLGDFGGDRMSKSDDRKDVLTNLILAKHPDTGEHLTQTDLETEASGFIIAGTHTTSATTTLLFYHLLHNPQYMEECVKEIEANLPPLTHGETAYSVSAAEASLPFLRNCIRENFRITPVFTMPLARRVMNPTGVVIEGQHIPQGTSIAVCNHAFHHNPDVWGDDHNIFNPYRWENPEIAAKARLLMHFGLGGRQCIGKTIAMTNIYKLMSTLLREFTFELADKQAQEKRLSSGDIPELISVGISDLKEPLMVRAHVRHSRMEKPGVQHVENDDGDENLAVKRRDGHDLEAFNGSHGKGIEENDSDTLTEDHRQYLIQKYGTVELDPIPDMTDADPYNWPTWKKVINLALVAFHAMMATFSASSIQSAFVEIAEDLGVSVQRASYLTSLVIAILGGAPLFWMPLSNRYGRRPIFLLSLLCSLVANVGCAKSPSYATMGFCRALVAFFISPAAAIGSAVVAETFFKKDRARCMGVWAVMVTLGVPLAPLLFGFVTSRVGYRWIYWILAITNGVQFITYLIFGQETLYIRGSPARHVSNPTLRQRFLDVKRIDPTPLKIWDFLRPISMATRPCVMIPAAAYAMVFLLGGILPSIEMPQLFPEMFGLDSEQVGLQFIAMIIGSLLGDQVGGFLSDRWMLYGRKKTQRSVAPEFRLWISYPGIALTIVGIVIFLVQLDHASSQWNITPLVGVTIGSIGNQIVTTVSFTYAVDCYRSEAASVGVFITLVRQTWGFIGPFWFPQMLENVGYLGSTGIASALIVAVSAIPMALLHWKGKAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQ15</accession>
    <name>A0A8G1QQ15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_507822</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510058.1">
        <property type="nucleotide sequence ID" value="XM_025664421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQ15"/>
    <dbReference type="GeneID" id="37167823"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="161"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="386"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="538"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="538"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH52136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="587" mass="65710" checksum="1136CD95D709CE8C" modified="2022-01-19" version="1">MDSFNVSDMSTALKESTGNQSSNPTEASNAAREKGWTTPKGYDYEKYTSTLPPLNQPQGDNQEELPEWAAQAAKYEWKDEFGDVGPRNPELEEMLFRSEYTNRTGLKIGNIQNIEVIAESRERPSPIKNFDDAGLHPIMRENIRLCRYEFPTPIQAYSIPAVLTGHDLISIAQTEAGSGKTAAFLIPVLSQLMGKAKKLAAPRPNVAAGYNPSADSVRAEPLVLIVAPTRELSTQIFDEARRLCYRSMLRPCVVYGGAPVRDQREELQRGCDILIATPGRLLDFMDKPHILSLRRVKYTIIDEADELLQSDWESDFAKIMSGGDINEDADHRYMMFSATFNKDCRKLARNYLAEDHVRVRIGRPGSTHANVDQNIIYAEPPLKKQCLYDLLLAMPPSRTLIFVNSKTQADFLDDYLYNMGLPSTSIHSDRTQREREDALRAFRTAKCPILVATGVSARGLDIKNVMHVINFDLPRVQHGGITEYVHRIGRTARIGNEGLATSFYNHDNDADLAPDLVKLLIESKQTVPDFLESYRPSDDVVKFDDDTDDEKSGGEDNSGNTDAWGGGGIPMESDDAEEAEDNSKWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQM3</accession>
    <name>A0A8G1QQM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF803 domain membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_215232</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825092">
        <property type="protein sequence ID" value="RAH51819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509741.1">
        <property type="nucleotide sequence ID" value="XM_025654640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQM3"/>
    <dbReference type="GeneID" id="37158042"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="407"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="487"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="544"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="655"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH51819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="692" mass="75617" checksum="D8E5CE5196B85080" modified="2022-01-19" version="1">MDSDNPLHPVNLLAARADSSSRPASYKAIGISLAIASGFFIGVSFVLKKKGLLRANVKYNEEAGEGYGYLKNLFWWGGMTLMIIGELCNFVAYAFVDAILVTPLGALTVVVTTILSAIFLKERLSFVGKVGCFCCILGSVVIALNAPEQSSVSDIQEMKSYVIAPGFLSYAGVIIVGCIVTAVWLGPKYGKKSMFVYISICSLIGGLSVVATQGLGSAILAQINGEAQFNQWFMYVLLVFVIATLLTEIIYLNKALNIFNAALVTPTYYVFFTSSTIVTSAVLFRGFKGSVSSIVTVILGFLQICAGVVLLQLSKSAKDVPDAAVFKGDLDQVREVATQEEPEFEPKADSIRATAAIIRRLSTPRRQMEAEEARRYFHDRAEDMKPPAENEVIEWDGLRRRKTVLGEGPTTLGRTRTLRNPSVKYPVPPLGMSHVPEERPDEPERPDTKQSSHSFLDDLRSRASSLFHPAWQPIQDEHATPDPVTMTALSAHKPHPDTRYPQSIADDSRSHTPWGEERGAPSPPPHGGARRQFSFNTMLHRMKTGHEATASRSSIPPRPPRHRAQSVTEEERLGLVRGDSRGETAPDDDVDEKLDRFDSHDGTFDDGPGRLPSGLMHSPELYPARLRVNPLPPLPDEEPLEDPYAPVDMGRRGSHSSAGTLSSSGRSMGWRRHGSASSGGSVQLPGRRGAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QR78</accession>
    <name>A0A8G1QR78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_431609</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="KZ825085">
        <property type="protein sequence ID" value="RAH52333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510255.1">
        <property type="nucleotide sequence ID" value="XM_025658340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QR78"/>
    <dbReference type="GeneID" id="37161742"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="5"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH52333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="365" mass="38823" checksum="33494094914EC771" modified="2022-01-19" version="1">MPAYNIVVFAGDHCGPEVTAEAIKVLRVIEKSRDDITLNLQDHLLGGASIDATGNPLTNEALTAAKNADAVLLGAIGGPKWGTGAVRPEQGLLKLRKEMGTFGNLRPCNFAAPSLVEHSPLKASVCEGVDFNIIRELTGGIYFGDRKEDDGSGYAMDTEPYSRAEIERITRLAAHLALQHNPPLPVWSLDKANVLATSRLWRKTVTEVMAKEFPQLKIEHQLIDSAAMIMVKNPRQLNGIIVTSNLFGDIISDEASVIPGSLGLLPSASLSGIPDGKGRVNGIYEPIHGSAPDIAGKGIVNPVAAILSVAMMMQYSFGRFDEARAIEAAVRNVLESGVRTGDIGGKATTSEVGDAVAAELEKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRR8</accession>
    <name>A0A8G1QRR8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_453948</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510350.1">
        <property type="nucleotide sequence ID" value="XM_025661167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRR8"/>
    <dbReference type="GeneID" id="37164569"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF25">
        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11C (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH52428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="268" mass="30244" checksum="71D3CBF2B1C46918" modified="2022-01-19" version="1" fragment="single">MTDPEPSSPPAAVADNEKHNNEGKPPQDNCSPVSSITGAGRRRQQLLAALKATDRTVDRFDRLISTAAGQERVLAVTGYLAHTLHHILSSAPWIAFQARLSLLARLRNNPKPPTNTTTSSSKSPLLALSSLMSETRFTLRLLGLFPLWTWGSQTLKHPPADKPLYILTLLQVFVNVIYQALENVGYLAQKGIVSKRFVDRWGGIDKWYIWSTRAWFGHIFFQFFVLWRGTVLRRKQMEEEKGEGGVVGKGEKREALRKEIRAWRKSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRV1</accession>
    <name>A0A8G1QRV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_383903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510349.1">
        <property type="nucleotide sequence ID" value="XM_025656530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRV1"/>
    <dbReference type="GeneID" id="37159932"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="530" mass="58172" checksum="9E776C06E9C132B1" modified="2022-01-19" version="1">MSSRLPVDEEERQESHSERSDSPSSQLVFLPPPNSEPSSVRWDQHATFEPVVDPFFNLVARREDGRPRLFPPFSGWNEDGSRACGDPYCKHDVVVHEHALDKHETCESCGLVPALGWFYRCGVDITGFSHRMDPGQAPVLSPWISDAIKAGHYTEIQKRILMWQKIRVLQTVAAEHSEHLVAFPVTEVIYGIGNDDDDENPHVDFVEDVSNPDPDQFAEDRPLLQSSVYPPCSHRACYSCAPRLQERAWGSINEVCRDTAVRAPSQWDLRDRSISDANIVRNLGLRRFSTARPGAESSTSLAEDSKSPSALLKKLVDRATNSSGSSKHAKQTTTVLPILTAQVAGSVAGCFTNAPPTASGVVRSTEPLATPSAQLNTQPSAAPLTAPPPPPHLEIPEWLMASGSSSGSLSTSSGARNSQAGPSQAGPSGTSRRTPTISRQLATAQGAWNSINKHPRRPNVSSRPPRTIVRVPATVNEEYEEDHWSGRGHEDEEDDVDEDYDEDDEDDESGGCLLDLASRAEEDREHRFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSA4</accession>
    <name>A0A8G1QSA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">High affinity zinc ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_156839</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511303.1">
        <property type="nucleotide sequence ID" value="XM_025654198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSA4"/>
    <dbReference type="GeneID" id="37157600"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000006">
        <property type="term" value="F:high-affinity zinc transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF32">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH53381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="354" mass="38941" checksum="9B9E3CF7B7BD9851" modified="2022-01-19" version="1">MSSFDPTNVNLDTASVEEIYCYLQLSENDYNGHLGARISAIFVILITSSASTLFPVVCKRIPRWNIPYPIYLFARYFGTGVIVATAFIHLLDPAYESIGSTTCVGVSKNWAEYSWCPAIVLASVMVVFLMDLASEVYVECVYGVEKEHDATDRFLAQANLIQSDDECTVNDDTGGSKQLGAQDDFCSIESERSFRKDIAAFLILEFGIIFHSVIIGLNLGVTGEEFSTLYPVLVFHQAFEGLGIGARMSALRFGRHWWLPWVLCMAYGLTTPISIAIGIGLRTTYNSGSKTANIVQGVLDAVSAGILIYSGLVELLARDFLFDPDRTKRRSHLLGMIFCVLLGAGIMALIGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSG3</accession>
    <name>A0A8G1QSG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_509855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825094">
        <property type="protein sequence ID" value="RAH51749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509671.1">
        <property type="nucleotide sequence ID" value="XM_025664512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSG3"/>
    <dbReference type="GeneID" id="37167914"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="53"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH51749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="563" mass="60636" checksum="ADB14373B6435F70" modified="2022-01-19" version="1">MAASSIDETGITTNSGQDANIAAQGQHAASTEVNNGVPETNPNAMHGFKLFAIFVGICFGAFLMSLDIFVIATAIPSITADFNDTAQLAWYPAAYSLTTCALTPLAGKLSSMFPLRWIYVSFFSIFLIGSLVCGFAPNSNTFIAGRAIAGIGASGVASGGFVIVLTVSPEKSKPVLLGICSSCFAMGLILAPVIGGAFTQYATWRWCFWVNLPPGALTLLTMLCFFRPPSIQRDRTAAQRFIDLDLIGCAIFIPSIFMLLLAMMWGGTKESWDSATTIGLFVGSGVMLMIFVSWEGYKGEDAMIPGNIVARRTITFSVLFSFFHFGSVGILNYYLPEWFQVVEGASPLQSGTRTLASVLAQIVGTLSAGFFARKIHYYNPWLYIGPLFMCTAAALYTHFSTFHTPSSHWIGFQVIQGLGVGMAQQMPSLIIQHSVRDKPELMPAAISLNLFFQYLGATITQSLGGIVFRSILLPELADHAGLNADQIALVSAAGMADVRDTVKQYFPDLLDLVLEAYNQAITSTLYVAVGTTAAAFCLAFGVKWERITEKATTGPEEAVAEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSK6</accession>
    <name>A0A8G1QSK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial genome maintenance protein Mgr2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_453767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510791.1">
        <property type="nucleotide sequence ID" value="XM_025661127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSK6"/>
    <dbReference type="GeneID" id="37164529"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH52869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="108" mass="11456" checksum="8375B08FD6855894" modified="2022-01-19" version="1">MPVVAGPPQGHGPSTFEKMKMGAMMGSTVGGIMGFIIGTVTIFQYGAGPNGVMRTLGKYMLGSGATFGLFMSIGSVIRTEGPHNDAWLRARGPPMMLPRQSPLRPMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSL7</accession>
    <name>A0A8G1QSL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_454295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509999.1">
        <property type="nucleotide sequence ID" value="XM_025661252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSL7"/>
    <dbReference type="GeneID" id="37164654"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43039">
        <property type="entry name" value="ESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="344"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="546" mass="61095" checksum="C97CDDF863BE02AA" modified="2022-01-19" version="1">MTTPGLLWVTMNPRPSLPAAQFHDWYNTEHGPLRLRLPFCTNGFRYRATDGEEPEWVALYDITDMVELTRETYLALRGDTIKTPREKATMAQIDVDRRLYDTVLEQKAADYKPLELTPDTEAAGSALVAVSLSLSSADAAKEDEFTRWYREEHIPMLSRVPGWRSSRLFVTSTIDPKAPREYLAVHEYAAQNGLGGPEYKAATDTPWRTRIMTDVVAKARRRTYQWAYTFGPAPRELSSLTSPDVIGPWSSIDGKTRTLPSPTRPAVESFVTTPDGVELPYRLEGSTDPHSPVIVLSNSILVDYTIWDDFVDQFLSDPRNQNFRIVRYCTRGRQQECGEKPVNIDLLASDIIALLDALRVPKATLIGVSLGGVTVLNTSLLYPERVERFISCDTNSSSPETNRKAWNERVELAASEGAVSPTTQQAIVGEKLAEITVRRWFTAESYETQPHLPAKAKELVRTNSLPGFRQSVQALCAYDVRDRMAQAQVPGLFVAGESDGVLPKTMQQMVADLKSKSELKLVPKAGHLPMLENATAFTQVVNEYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSZ4</accession>
    <name>A0A8G1QSZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="4" type="ORF">BO85DRAFT_493158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSZ4"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000143">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH52257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="366" mass="41078" checksum="E7C37BEE76C633F5" modified="2022-01-19" version="1">MPGKELPDHCMNCHEAEPAFTLRERFVCQECYIRFLNFKPFRRMERYRLRRNMPQTGPCKLLLPLSYGVSSTVLLHMLHQQLEVLRSKKHGPAGFEILVLVVEPSTISPVPPHEEGFALAQQTFPLCSFTRLPFHSIFELDPDVHQIMSQYAGENFTDDTSLSNEERLTRFRRSISSATSKSDVDQILLNKLVVAFAKKMECRGIVWGDSDSKLAAKTLANVAKGRGSAVTWQVCDGMSPFGLEFNFPLRDVFTAEIRTYATLFPELAGIIVHDEPPSENTLTKNLSIDELMIRYVSTQGAKYPGVMLNVTRTASKLQSSGTSIGGLQCDFCGAFMTTNENITGEQGHEQLQFCYACARSQPELTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT51</accession>
    <name>A0A8G1QT51_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_432292</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510031.1">
        <property type="nucleotide sequence ID" value="XM_025658375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT51"/>
    <dbReference type="GeneID" id="37161777"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF77">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034969825" evidence="9">
        <location>
            <begin position="23"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="14"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH52109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="497" mass="54728" checksum="5050226C28F15EDD" modified="2022-01-19" version="1">MASQKQWSRMLIFTTVLLAVSAFNYGFSDQAFSSCQAMDSFARQFGVYHPSTGTYKVKPLFTSLYNSLKAGTQIVGVFLGGYISNTYGRKWCIFSMNLYALGSAAVVVSSKTDAQILTGRALHYIYLGMQLAVIPTTLAELAPRNVRGAMGVLYWLSIKIGGLVVTGIARGTSGISTNAAWQIPFGLILVIPFICIWLVWIIPESPRWLLLRDRQEEALQALKRYRSKNTPEHEIQEDFEEMAQKVTAQLQKKSFKDLFIKGNRERTFVVAAANFFQQASGQAFASQYGTLFVKQLKSVNAFSVTLGTNATDIGALIISTALSDVVGRRMLFHVSGFLETASLMTMGGLGTADPSNTAAKEGIVAMLLLYSFGWSLAWAPLVYVLGAELPSAGLREMTLRIAYTVKLVTEFAVTFSYPYLETADDPGHVDIGGKLGFIYGSLSAVSVIFGYFFIPETRKLELEDINKKYESSTESELEQKVEYQVGLREIGRSGGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTI6</accession>
    <name>A0A8G1QTI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phenol monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_381775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511316.1">
        <property type="nucleotide sequence ID" value="XM_025656437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTI6"/>
    <dbReference type="GeneID" id="37159839"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF15">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="42"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="476"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH53394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="73421" checksum="2E79D3A78157E356" modified="2022-01-19" version="1">MPVFTEFASKSRDLRVLPSFALPLPRLTPPFEPTVNDGVERYEVVIVGAGPSGLMLELLLARYGLSDESLLCIDSKPSTLKSGQADGVQPRTLEVFKTLGISDEIENEACQMWQFAFWNTSSDPSKIIERKSVVPEVIPPARFRYEATIHQGRIERIMETDLLRYSKRGVQRDTKLIHVQLNEDDKEFPVLAEIETRGVRRLVRTKHLVGADGAHSMVRQCVGLKLEGQSLDHIWGVIDLVVDTDFPDIRRRCAIHSPAGSVMVIPRERIVTGEYLTRLYVQVPGMASPNGDIVGAAAPVSEIDDARVRRQQVTKEGILKQAADAFKPYYLKPKSEESIDWWAAYQIGQRVSPEFMVKDSTGVPRVFIVGDACHTHSPKAGQGMNVSMMDSYNLAWKLAYHIHGLSPSSGEPDQPHPLLDTYHLERHANAQQLIDFDRKFSTIFSGQLDTEESGMSHAEFVATFNTGNGFTSGCGVEYGESMIVDRTASEGQDNPIQGDDYLSGILRPGRRLLNVKLRRHADGWHRDIQDDLASTGRFRVLTLTSNDLLNVQSVSARSLQDVSALLGTFPAGIVEQIVVHPQLPREFEWDSLPGCVKEHAEMRFYNGSELEDAYEIYGVDPHQGAMVVVRPDGYVGIVVALGKVDRVGEYLRRCIRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTQ3</accession>
    <name>A0A8G1QTQ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_442409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511339.1">
        <property type="nucleotide sequence ID" value="XM_025658839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTQ3"/>
    <dbReference type="GeneID" id="37162241"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF4">
        <property type="entry name" value="GDP_GTP EXCHANGE FACTOR SEC2 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="160"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="175"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="257" mass="27903" checksum="A59A260DE27E9B9D" modified="2022-01-19" version="1">MSTTTTTTALTSTTLIGTLPSMAGAAALVSGKACPTCGQDGFLAAGQSTNDTRRRAKDLEGQVNALNLQAMQMAEKLAAYEEEIRRLRAQPSSRNNTSVSSTASTQIDRSQSPTHLQTSPKSQPGRLSTLASFLPSRRPSATSTTQAQPVASPPPPEPVQPTTTQEETVELQNALTREQSLRKAAESQLSQASTELEELTAQLFSQANEMVAQERKARARLEERVAVLERRDVEKRARLERLEKAMARVERIRAMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QU24</accession>
    <name>A0A8G1QU24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_472436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510764.1">
        <property type="nucleotide sequence ID" value="XM_025662552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QU24"/>
    <dbReference type="GeneID" id="37165954"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="148" mass="16321" checksum="C9A3E6E347ED02D3" modified="2022-01-19" version="1">MVDVGSAKLRQNTRDARGFFGLFGTFRCWDTRRVLAEMACEGNPSAALDSVLYLAAHFKLSPTAAALRMRPAVAASGVCRSLDGSSGWLEMVRSRSKVRPDLSCLLVLWGKSLPYKGAGSKSEKEMAVVGRLPMIWGMFPEDYNNHKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUB6</accession>
    <name>A0A8G1QUB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_454665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825099">
        <property type="protein sequence ID" value="RAH51640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509562.1">
        <property type="nucleotide sequence ID" value="XM_025661339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUB6"/>
    <dbReference type="GeneID" id="37164741"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="6">
        <location>
            <begin position="50"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH51640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="345" mass="38854" checksum="524C58ACCC525773" modified="2022-01-19" version="1">MTTVDPITKTTFATMDWEDYHQGRPQYPQSLTSLIYDYRRLHPGGWERLVDIGAGSGIATTNFMTDFQIIHVSDPSPGNQSQAKIFLPNWAEQHGLHPTFEYSQAVGEEAYHQVGERQADMAICATAAHFMDPYKLVISIGKMLRPGGTMAIFSYWLPTFPKQSSHFHDVFASIFAKVLLQPLQQDAESNQAAMLYGLMQRLGSGEGQVDSVPAPEELFEDPVRVYINPTDDGKMPYYAQFVKYFPAGLQPEKYSAVAGRDKQVRYYTGSDDEAEGWEFDADKQWLLKFLNTCLPPQHTLAPDTAHVLLADWDRVFEKECPSGQLRVRWAANLLLGTRKGGEDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUK9</accession>
    <name>A0A8G1QUK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_463223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511173.1">
        <property type="nucleotide sequence ID" value="XM_025661908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUK9"/>
    <dbReference type="GeneID" id="37165310"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34673">
        <property type="entry name" value="COLD-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34673:SF1">
        <property type="entry name" value="COLD-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="79" mass="8317" checksum="F6DE720AA7E91D7D" modified="2022-01-19" version="1">MCDIPFLPIFPICFQCGTDQNPCRCKVVGPTLGFLCTVVAAVICYPASIFCGCCLTQTGKDVLGYPVKVNGAVSNAIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUR8</accession>
    <name>A0A8G1QUR8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative TATA-box-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_160504</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511154.1">
        <property type="nucleotide sequence ID" value="XM_025654228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUR8"/>
    <dbReference type="GeneID" id="37157630"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH53232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="262" mass="28187" checksum="A8B9EF008D38030B" modified="2022-01-19" version="1">MDSLTTHPSTAQQARAFTSPASLSFPGGAGDLTPPSDKDGNMAMAQGANGMMNGQQQGGNAANGNGVAPATPAATPGANTPGSGIVPTLQNIVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQKLGFNAKFTDFKIQNIVGSCDIKFPIRLEGLASRHHNFSSYEPELFPGLIYRMMKPKIVLLIFVSGKIVLTGAKVREEIYQAFELIYPVLSDFRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV24</accession>
    <name>A0A8G1QV24_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone deacetylase</fullName>
            <ecNumber evidence="3 11">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_452555</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3 11"/>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512111.1">
        <property type="nucleotide sequence ID" value="XM_025660846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV24"/>
    <dbReference type="GeneID" id="37164248"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031078">
        <property type="term" value="F:histone H3K14 deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019154">
        <property type="entry name" value="Arb2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017321">
        <property type="entry name" value="Hist_deAcase_II_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09757">
        <property type="entry name" value="Arb2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037919">
        <property type="entry name" value="HDAC_II_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="13">
        <location>
            <begin position="152"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2-like" evidence="14">
        <location>
            <begin position="511"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="766"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH54189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="800" mass="89056" checksum="009DB7919D6193DA" modified="2022-01-19" version="1">MAMDEDEDTVMGEVGSHHPTSVSSHQWPSNGPSSQGAGQLNGSSDPSIAPPLLGPTMKLPLSVHSGDQRPENTASAEDQGVSPPKSLPKSDSGDATTEDFDKQDSLVEDNSDWTDEDTVARTGLPIASLPSGLCYDVQMRYHCEVRPTADVHPEDPRRIYYIYKELCRAGLVDDPESCRPLVSRPLKRINARNATEAEISLIHTPDHFAFVESTKDMSDDELIALEHTRDSIYFNKLTFASSILSVGGAIETCLAVATRKVKNAIAVIRPPGHHAEHDKTMGFCLFNNVSVAARVCQNRLGDSCRKILILDWDVHHGNGIQKAFYDDPNILYISLHVYQDGKFYPGGEEGDWDHCGEGPGVGRNVNIPWPSQGMGDGDYMYAFQQVVMPIAHEFNPDLVIVASGFDAAAGDELGGCFVTPSCYAHMTHMLMTLANGKVAVCLEGGYNFRSISKSALAVTKTLMGDPPDRLHTTSPSALATTTVRRVMMIQSHYWHCMYPKGPPQDGLFTDRLHDVIRAYQSKQLYDNYKLTSLFIYRTAISRSFENQVLASPNYHQAVPLVVIFHDPPEIMGLPHPVTNKLEAHNCWLADVMKEYIGWTVSKGYAVIDVNIPKHVTIDPSSGKYEEEDENRPTATEELAGYLWDNYIEPSEATEIFFIGVGNAFYGVANLLINRETLYKRVNSVVSFVAENPVRAIASHTQVWLSRWYKDNSLVFVSHTHGVWNNVETRRKPSKRYGQLVQSPKASLSEMLMHHKEEVYQWISERADVQDSEETEDEKKPKSKSRSPTKENQAEPRSVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV60</accession>
    <name>A0A8G1QV60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_428112</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512150.1">
        <property type="nucleotide sequence ID" value="XM_025658193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV60"/>
    <dbReference type="GeneID" id="37161595"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF32">
        <property type="entry name" value="TRIPEPTIDYL PEPTIDASE SED3 (AFU_ORTHOLOGUE AFUA_3G08930)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034787953" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="20"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="205"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="538"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH54228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="588" mass="63903" checksum="2E9F64E0DE494DCC" modified="2022-01-19" version="1">MTYLKYLLGLLSLLHTGLATAPDYVVVDQLSSIPEGWSKGTAPSPSTPMKFWLSMHHDYKADFEQKVIDISTPGHRDYGRHMKRDDVRAFMRPSDQVSKTIFSWLESEHVPSDAIEDRGDWVAFTVPLAQAQAMMKTDFYNFHHLETNTTQIRTLKYSVPEEVDAYLQMIQPTTRFGQPKTQTSLPSLMPVSINIDEISEDCLTGVTPTCLRQLYGLPSTKATPDSRNVLGISGYLDQYARYSDLDEFLEVYSPDSIDADFSVVSINGGQNPQNSQEGSTEASLDIQYALSMAFNANATFYTTAGRAPSVSDTGTVSTDGSTNEPYLEQLHYLVGLPDEDLPAVLSTSYGEEEQSLPEEYTEATCNLFAQLGARGVSVIFSSGDSGVGGACVSNDGSQRTRFQPIFPASCPFVTSVGGTEGVEPEMAVDFSGGGFSERFARPSYQNASVEAYLARLGDKWDGLYNRDGRGIPDVSAQASNYVIRDHGQWLQTAGTSAAAPVFAAVISRLNAARLKQGKPTLGLLNPWLYSLDQKGFTDIVDGGSVGCEGSNGGALVPYASWNATKGWDPVTGLGTPLYQTLEQMALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVE6</accession>
    <name>A0A8G1QVE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_452897</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511608.1">
        <property type="nucleotide sequence ID" value="XM_025660932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVE6"/>
    <dbReference type="GeneID" id="37164334"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13934">
        <property type="entry name" value="RNase_H_Dikarya_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="66"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH53686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="251" mass="28030" checksum="8E740DA0B0CB52B5" modified="2022-01-19" version="1">MGTLMVVINPIMAAGGYDNDRRVGTGLVLPTKFNPPYPDDTPHSLFPPGIKVDCVPQVHRFIRRNNPRELLTYTNGTCVENGGAVPRGGCGEPRGGCGVVYRSPVDLPEGKLNHFKVPLEIKGPSGRRHPHTSERAELRAVIAALRFRCWTGEGFNKLVIATDSEYVVEGATCWVQGWIQRGWKTRTGNPVSNRDLWEFLLGELERWYDHGMDIQFWQIPKEWNTEAARLAEQAALETPARAFGDVSGYMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVY0</accession>
    <name>A0A8G1QVY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_105318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512479.1">
        <property type="nucleotide sequence ID" value="XM_025653818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVY0"/>
    <dbReference type="GeneID" id="37157220"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="1">
        <location>
            <begin position="32"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="162" mass="18140" checksum="20693C01B02F7DD8" modified="2022-01-19" version="1">MPKSCETRDYRRSRCHTEHHLVSVCLLRHLLASITYLAPYTAQCNAVRTTLSILHLQEPTVGFNRILVKTTDSFQGGKVAVMFLDTTATDRPGFLKQRGRLNVALSRARAAIYVIVNVKQWNKAKQSSGVSTYVPWWISFSSNRKCRVRIPPSHGGGSKPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWE6</accession>
    <name>A0A8G1QWE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_451764</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512810.1">
        <property type="nucleotide sequence ID" value="XM_025660667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWE6"/>
    <dbReference type="SMR" id="A0A8G1QWE6"/>
    <dbReference type="GeneID" id="37164069"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="58"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH54888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="137" mass="14981" checksum="950572AF92BB21C6" modified="2022-01-19" version="1">MFRSAVVRSLRASVPRAVKTPAPFQIRSSPVARPAQFAPRFAYQGVRLYSAPAGLNKDEVEGRIVNLLKNFDKVSDASKINGASHFANDLGLDSLDTVEVVMAIEEEFSIEIPDKEADSIHSVDKAVEYILGQPDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWH2</accession>
    <name>A0A8G1QWH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ima1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_451728</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512779.1">
        <property type="nucleotide sequence ID" value="XM_025660655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWH2"/>
    <dbReference type="GeneID" id="37164057"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034992">
        <property type="term" value="C:microtubule organizing center attachment site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071765">
        <property type="term" value="P:nuclear inner membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042321">
        <property type="entry name" value="Ima1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018617">
        <property type="entry name" value="Ima1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538:SF1">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09779">
        <property type="entry name" value="Ima1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="625"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Ima1 N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="682"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="814"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="682"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH54857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="859" mass="96149" checksum="AACCE21E94910AD2" modified="2022-01-19" version="1">MASLFAKRFKCFYCGRRSAHSDSDTARKWRCKHCEAVNYLDEKGEITDPPAAETNPDVYGPGASSPPFESTDFTASSLFCAQCLRNQHLFTSALASYFPSSDDPNYSAYEKEYPKFRKNLEERYPQVCVKCEPRVKQRIRQAGYEAKSDHLRRMMDRSKAGRAARQARRWNWRNLLVLAGALGYWISVAGQLSWNVWSALTVEEWEPLQDPDSPSMSPSIFSCVNLLFETRRVPNHCSIDLAPYAGLALIAGILSIWWNPKLRLKVEGRGGRFVKLGEYYQVQLIILVVRCAFWGVLRDPSSSGLPPDLPPTLHLFMIFFTIMSVMVSRRIVRYDTRPLVDWTDDTPAATPNRRTEASPPPSTTTGQEFSTPSSNLRQRTSRFPLEKLGTPRATTPRAALETPTIPTPPPESDDMDWTPSVQHELTPTVSVHQRDQKSVLDGPMPFYGSVPAAPQPPAWNLRNKPAQRVKPIEQVVERNPFHRTPTQNLRWHRNQNSPDSVFAPPKFFPVSDHAATTGLESLFDRTFTIKSPEDEEDSSWQSRHQSSNSHSRQSANLRGYFVYQYLRLGLLLVSLVAWVLSQYDRLSIPGNYVEVASLGSASLIAGFALLEALKQPIVQWNGMEILVYFAELVAAVHLGGNLPRVSIERHYFDRYGQLLLVFMAVQEALGLLSLYNIARASSTGPQPQQSGHNSPSNGENPGHSPQPAIDYQPLQSFSSQRSAPPLSFSSTLPTSSFATQSPEPYYSLAPSPYDGSSSKDHSFSLKSLKGNDSDASDYYDRDSDTETTVTTATTATSNTVRNIRYGRAASEAMFSPRRTELGPGIGGLSLEDRPARRVTRSQSKLQGEGFRRFPTRGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWJ5</accession>
    <name>A0A8G1QWJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_89189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512906.1">
        <property type="nucleotide sequence ID" value="XM_025665763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWJ5"/>
    <dbReference type="GeneID" id="37169165"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="211" mass="24366" checksum="A148EE7481435731" modified="2022-01-19" version="1">MFFIFVFFTIWLIYFCLETSILSRTYPLARICLHLHLCHYSVPVLPCFPLFMEHLLESLCINLMCVDRAASRGKHYWQTTWKTRDHTVSRLIVAFLFSFPSLLLFFLICRCFSDYYFFTPHSALFPPTNTLFDPPPGPLCAVSGEMGWSNSTDKAPIHKGPCQVLRPASNRGFPPPHGLPRFFFDVRPRQDGIFVPSRYLACLSVHADMCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWZ2</accession>
    <name>A0A8G1QWZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">7,8-dihydro-8-oxoguanine triphosphatase NUDT15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_479714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513146.1">
        <property type="nucleotide sequence ID" value="XM_025662964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWZ2"/>
    <dbReference type="GeneID" id="37166366"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04678">
        <property type="entry name" value="NUDIX_MTH2_Nudt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000060">
        <property type="entry name" value="Nudix hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099">
        <property type="entry name" value="8-OXO-DGTP DIPHOSPHATES NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099:SF5">
        <property type="entry name" value="NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH55224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="148" mass="16727" checksum="C8B8E3DB6EC4007D" modified="2022-01-19" version="1">MKPRVGVGVFVINPKGQIVLGQRKSSHGAGTWALPGGHLELNESFEDCAAREVLEETGLIVRDIQFLTATNDIMREEGKHYVTVFVGCTVVGDDAQPELLEPHKCEQWKWVTWEEVSSYHSDPDSNHRLFIPLVNLLEQRPGFHPVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY05</accession>
    <name>A0A8G1QY05_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_51527</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514408.1">
        <property type="nucleotide sequence ID" value="XM_025664776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QY05"/>
    <dbReference type="GeneID" id="37168178"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="523" mass="59612" checksum="DB9D85CD641B9B69" modified="2022-01-19" version="1">METKRRRKYAPKSRTGCRTCRTRRIKCDEAPGACKNCTSTGRTCDGYDFTRLPTSVGGHLHNASRPKFQLRVCLPGMSSDERRCFTYFQTHTVPRMVGFFDSELWQRLALQLSQAETAVCHAVVALGALHQDSEARGMLVQKVDLDRNDHHRFALEQYNRAISALQKRLQSNDPQARLAVLMCCVTFVFFEYLQGNRAKAFAHLQNGLQVLANRKGNEARTLVMSKVFQPAQESTAERALLRAFAQLDAQSAFFKVSGSVTRLGAQNGYLTTDIFNQEFDFQSLEDVKGKLDPLGNVIFRFRTTCRSLLCNPMADVLQLTVEHHKLRTQLMKHISAFEAFRARIHPSNMTTKEARSLDTIRLHHIVLMVDLETVLSLSELVYDYYLPQFRTFVDLCERIINSMRAEYGQDLTKIVADIGIIAPLGWTSLRCRDLPTRQRALSLLDSWPHCEGPYDSRFFATLARQVVAIESEGEVAGFIPEYARVRDTSLEMLGDGHHAVLCYTLSDPEKMDLQVHRRPFLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYQ0</accession>
    <name>A0A8G1QYQ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Lysophospholipase NTE1</fullName>
            <ecNumber evidence="3 16">3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Intracellular phospholipase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO85DRAFT_450663</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the NTE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 16"/>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513934.1">
        <property type="nucleotide sequence ID" value="XM_025660428.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37163830"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000062">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000007">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000018">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 15 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 16" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11 15 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="18">
        <location>
            <begin position="698"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="18">
        <location>
            <begin position="849"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="19">
        <location>
            <begin position="1228"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="303"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="763"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="15">
        <location>
            <begin position="1232"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="15">
        <location>
            <begin position="1259"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="15">
        <location>
            <begin position="1379"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="768"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="1261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="1379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RAH56012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1531" mass="168876" checksum="83EE80C1D4AEBD85" modified="2022-01-19" version="1">MATGDGIIAALPSLESSSLDPLHVLPASSSTAARSLATSIPALTASFSVVSGFSSHLPPPPITPPAPSTMVGWIGWIFSFIFQVIPSVLYWIVTFTTITLPTWLFTLFSMSLTFTMNFTTLLLIALAVVSTISWFIRYRFLNMYSRLPPEPQRKEPQLDLFPDVPDSDTKPGLANYLDEFLSAIKVFGYLERPVFHELTRTMQTRKLIAGETLLLEEEKGFCLVVDGLVQIFVKSMRDRKSGTDEELNRMAGESSDEDDHRPDGRQGYQLLTEVKNGASMSSLFSILSLFTEDVQLRYADSSASSASSIGPGLAIGPDSFPASPREMDDSPHVYQGDRLDPASHRNSTAEDLPAVPPLNLGESQVPPAHSARSGSRKYSGKTRRKSVHPDIVARAMVDTTIAIIPASAFRRLTRVYPKATAHIVQVILTRLQRVTFATAHSYLGLNNEVLGIEKQMTKFTTYDLPNELRGSALDRLKDKFIKERDRLGQEEVTKGIALHNPYGGRRPRSSSFRRKEAALQAKMAASKRPVSMVAQDSALSDRENSGVSPGDLLSTIQLSRFGPRYEHLAPRLLSPLTEKEHSPLRSPSPMIPGRASPFHRKESLDEDALFRESILECIMKGIGLTGSTNDFLRKSSHPSGDVSPKLLSYDSRRQKAVFSNNAFGFIDPYEGSADGESESMMSMSVTSAGGTSPIVNLREELRNDIEIVYFPQGSVLVEQGERHPGLYYVVDGFLDVGIPVDDKEEDLVGSSRPAHEELFPTLRRTNTSSSRVSGSAAAANDPRRKKQSRKSLYLIKPGGIQGYVGAVASYRSYTDVVAKTDVYVGFLPRASLERIAERYPLALLTLAKRLTSLLPRLLLHIDFALEWVQVSAGQVIYHQGDESDAIYLALNGRLRSVHEGPNGKMTVVGEYGQGESVGELEVMTESTRPATLHAIRDTELAKFPRTLFNSLAQEHPGITIQVSKLIAQRMRDLVETPVAEKGSEPGASGTVKTAKSTLNLRTVGILPVTAGVPVVEFGNRLLQALHQIGVTNGATSLNQAAILNHLGRHAFSKMGKLKLSQYLADLEEKYGMVLYIADTTVNSPWTQTCITQADCILLVGLAESTPSIGEYERFLLGMKTTARKELVLLHGERYCPPGLTRQWLKNRVWINGGHHHVQMAFRLTAEPSHPQTKRFGTVLKQRVQVIQAEIQKYTSRRIRQSPLYSAQTPFKGDFHRLARRLCGRSVGLVLGGGGARGIAQVGVIKALEESGIPIDIIGGTSIGSFIGALYARDADVVPMYGRAKKFAGRMGSIWRFALDLTYPTVSYTTGHEFNRGIFKTFGDSQIEDFWLEFYCNTTNISRSRAEYHSSGYTWRYVRASMSLAGLIPPICDEGSMLLDGGYIDNLTVDHMKGLGADVIFAVDVGSIDDNTPQGYGDSLSGFWAVVNRWNPFSSCPNPPTLSEIQARLAYVSSIENLERAKNTPGCLYMRPPIDPYGTLDFAKFDEIYQLGYAYGKNYLEKLKREGSLPIPEETEEKKKLQRTLAPRRASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ14</accession>
    <name>A0A8G1QZ14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L38e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_449763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514948.1">
        <property type="nucleotide sequence ID" value="XM_025660226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ14"/>
    <dbReference type="GeneID" id="37163628"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH57026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="80" mass="9204" checksum="AB5DC2AF059000FE" modified="2022-01-19" version="1">MPQEISDIKQFIEVCRRKDASSARIKRNPKDQQIKFKVRCSRFVYTLVLKDSDKADKLKQSLPPALKVVDVSKGDKKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZR2</accession>
    <name>A0A8G1QZR2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_460101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514646.1">
        <property type="nucleotide sequence ID" value="XM_025661696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZR2"/>
    <dbReference type="GeneID" id="37165098"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677">
        <property type="entry name" value="YALI0B19030P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH56724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="221" mass="25099" checksum="F61B7EA854003C98" modified="2022-01-19" version="1">MALSAIFIQVELPTVIGLATSKATRPSSDLPELVDPTKRLNNPPPMSIYTMKQTRLEGHNMPLHAATDPFPLFPEQPWHTRVPFKIDVRKLLEVLDRTSELPVIAWCHDNFPLVYVIFISDCTEIASRETALRTPSGRLWNFRTTAVMQGRCTEGRALKALDGREHLSMVTCRGGTFYSSKKKKRGSVLAKRPYETPVMKHFLNDRMFFVESISTQIQKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZX6</accession>
    <name>A0A8G1QZX6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_39959</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514625.1">
        <property type="nucleotide sequence ID" value="XM_025657104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZX6"/>
    <dbReference type="GeneID" id="37160506"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="3">
        <location>
            <begin position="178"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH56703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="360" mass="40654" checksum="B5576651356212C8" modified="2022-01-19" version="1">MTDLTSVPIIDFQRLKDPETKAETLAQLRDAIFLVGFLYLTNHGLESLTKRAHATLLDLFSLSSETKEQVNMINSPSFLGYTRLGAETTALKTDMREQFDFGTPNLPPSNPQTAPIWSRLEGQNQYPTPATQSLVEEYMTSFIPLSNTFLQYVAESLSLPPTTFDTYRGTMDRLKFIKYPPQPSSGEDKSQGVGPHKDSTGLFTFLSQDATGGLQVINKRGDWIDVPPLQDEGALVVNIQQGFEAITGGVCSATVHRVVAPKNTTRYSIPFFMGIRMDLTLSNLRDSARHIVEKVPVGEWSDEDEMKRRAEDVPSEFLSDRFDCFGEAYLRNRIISHPDVGKKWYPELYERYSNDPFYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0H6</accession>
    <name>A0A8G1R0H6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_374447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514323.1">
        <property type="nucleotide sequence ID" value="XM_025656129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0H6"/>
    <dbReference type="GeneID" id="37159531"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF57">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH56401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="654" mass="73525" checksum="C2D4BB12A21B317D" modified="2022-01-19" version="1">MESARRYNVERSCLRCHQRKVRCDKSSPCGACIRANVLCQYPGPNRAKRRPPKVHNSDVIARLESLERSIAALVGTRSLPHLQHEVTDGRAVSAPDAGSPSSKAPSPTGTTAAAEPSHDGLLVEDGRYINEQLLSRVLEDEKELQSAIGTPKSDTSSSRRPLTLRAEGLLVSRSVDEGHLYALHPCQWQSTQLWQTFLNRIDPIIKILHVPSTQPRVFAAINQPAAAPADLHALLFAIFFAATTSVLAEDPAHEQRQSEVKRYQQGLELALYQSNFLDAPTLTSLQAMSIYQMCLRYYNSGRSGWTMRGLVIRAAQSIGLHRDGRHFKLTPLECELRRRLWWHICTADSRAVEDHGVGVNSGEEVYDTAFPANIDDQDLSATAMVPPDSKDCWTEMTASLITTVVNEKRLELHRTLTTKVTGKDPAEIVREAKEHVYNTYTKHGDPNIPIQRHGMLLGEVLVLKMEMYLNQKALQTNSTSIPVAERRELQTKTLDISCQALERTNEMFTDALLRGYRWLSSTFMPYFLLTYILWHLCVYPLGVHVERAWRAVNLVFDLTEKDPLWPNPGPKWAIITRLRDKALYIRQMQVAVEQAAGSVDETQPTGTSQAEAPMVESFFDFVNWDIGVLGFPDWTGLMQSVDITGFEHSMDTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0L2</accession>
    <name>A0A8G1R0L2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_497521</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513991.1">
        <property type="nucleotide sequence ID" value="XM_025663996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0L2"/>
    <dbReference type="GeneID" id="37167398"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF96">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE STCB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH56069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="480" mass="54177" checksum="EF85EDFF18AA3A3E" modified="2022-01-19" version="1" fragment="single">FTQQARWGPTSWLAMSIYRERRNPLSSVPGPFLCKWTDIFVRYQTVIGNRPRYVQALHRQYGPVVRVGPNAVDIAEIAGAREIHRIGSGFLKSPVYELLKHDNAKSIFTTSDPKFHSKHRRLLSSPFADANLHSLEPLIEGRIRLTMKRMREEMTIRGVADVQKWFSFMASDIIGELSFGDSFRMLEQGKKNQHIKDMEIAAFVGETRAAFPVLSMLAAFLPIPFFKEANKSRNRIVEYTDESINRYKKLLAASPDNVKPTLFTKLYNAGKAGLPDAEIRDDASDLIIAGSDTTANTLTYLTWAVCKTPIIRQALVAEVATLPEQFSDKDVQNLSYLNQVIDETLRLYPAVPCALPRVVPPHGAIFGGHWVPGGSTVTTQLWSLHRDPVAFSEPEKFDPSRWSSPTQEMKDAFMPFGAGTRNCLGLHLARIELRLATAHFFRQFPRSEVSSREGMSDDDMEQVLHFLVSTKGHRCLLEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0L7</accession>
    <name>A0A8G1R0L7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_29563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH56972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514894.1">
        <property type="nucleotide sequence ID" value="XM_025655299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0L7"/>
    <dbReference type="GeneID" id="37158701"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="96" mass="10983" checksum="908D6422E7965E81" modified="2022-01-19" version="1">MVAEVRPHEVLTKLVGVGSPLRALLHRVFFSPLFTVISPTLGDNRLHTYYLLYYLSCRSLLLTLHLLFPSLTTYTFALLLKATTRRSYFQAQVITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0Q0</accession>
    <name>A0A8G1R0Q0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cation chloride cotransporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_488507</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514939.1">
        <property type="nucleotide sequence ID" value="XM_025663537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0Q0"/>
    <dbReference type="GeneID" id="37166939"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000013">
        <property type="entry name" value="Solute carrier family 12 member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF72">
        <property type="entry name" value="GH08340P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="544"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="141"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="10">
        <location>
            <begin position="629"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1013"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1022"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1093"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH57017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1250" mass="137609" checksum="0341F91E45CAA57D" modified="2022-01-19" version="1">MTDGRADSASESLSRRRPNFSTRAAEEDVSRLDPSESANASPEESSKFLHGRMNSSSHSHEPPHFHHRSSESRQQSQQNVIDNVARWWSGQGSDGKHELPRERLNANRSPPGPFREGQKERDSQKDRTLDNPDKLGTFSGVFVPTTLNVLSILMFLRFGFILGQAGLLGMLGLLVASYTINLVTTMSLSAIATNGTVRGGGAYYLISRSLGPEFGGSIGIVFYLGYVLNTGMNAVGLVDCFTQNFGSESGTWGNFLREGFWWQYLWGTVILIMCTAICLAGSSIFSRASNGLLIILLIATFSIPVSAVFMKPFSIPKVGVEFTGLRLQTLLENLKPKLTKGAAGSQIRGRENFQDLFGILFPATGGIFAGASMSGDLKNPSRSIPKGTLCGLVLTFITYAIVILAMAASITRESFYKNANVVQVANLSGAVILMGEFATSFFSALMGVIGSAKLLQAVARDGLLPGLSFFGKGTRKTDEPVNAIIVTYMVAQLTMLFDINQIASFVTMTYLMTFLVTNLACFLLKIGSAPNFRPSFHYFNWKTAATGTLVCGASMFFVDGIYATGCVGVLMMLFLLIHYTSPPKSWGDVSQSLIYHQVRKYLLRLRQEHVKFWRPQILLFVNDLSEQSKMISFCNSLKKGGLFVLGHVLVTDDFTTAVPEARRQQTAWTKFVENSRVKAFVNITVSPTAEWGVRNVTLSAGLGGMRPNIVVIDQFREGKSLVERPSLSGRRESSGRRISRELVPVISEDGSQEPPMSTKTYVTILEDLLFKLRMNVAVAKGFEDLELPGPHGQHTKKYIDLWPIQMSAELGADSESKKNVLTTNFDTYTLILQLGCILNTVPSWKKTYKLRVAVFVEYETDVEDERGRVEALLEKLRIEAEVLVFWLACGDLKTYRIIVNGDISPETEDAEPRVHEALRNEEWWQDIQKSRSEHEAQQRAEVGAIKRADERIPSWPMQSPESAHKPLQPLAGGLRKLVESSKRRRSISSFRGLGSVSLGMQTHRLLDAFVDYESSESSTGESSDEAEFPPYLDEEDDEEENGQEAEHRIQSSQSEPAGSSKAKQKVTEEVAPDQAVPSIIMTCDDGTSPKTQSSPSRPKFNRSPSSSRFSSSPIPEARVNTEEGAGPSIMFAPNASPPRTSNRIESIYTRRSSSGPSVPKTASGYPRQASVPLSFNDLPSRAQHLILNELMNQHSEDTAVLFTTLPSPSEGTAQSEAASASYLSDLTVFWQGLPPCLLVHSNSMTVTMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R128</accession>
    <name>A0A8G1R128_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-isomer-specific 2-hydroxyacid dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_478054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515520.1">
        <property type="nucleotide sequence ID" value="XM_025662868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R128"/>
    <dbReference type="GeneID" id="37166270"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12169">
        <property type="entry name" value="PGDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="27"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="120"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH57598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="341" mass="37593" checksum="315256DD63BC3D89" modified="2022-01-19" version="1">MPPKVAILDDYQNISPRHFAHLTSRVDISYFPDTLNPRDPAQHKQLIQRLYPFEIIVTQRERTPFSKETLSALPNLKLLLTTGTRNLALDSAYCAERGIPVAGTKYRLTGVHSTVQHTWALILGAARHIARDDAAIKRGEWQGSLGLSLAGRTLGLLGVGKLGAQVGRVAVQAFGMKVIAWSTNLTQEKADEQAEAMGLPAGSFEAIPKKLDFFQQADVVSLHNVLSERSWGIVGREELGAMKKSALLVNTSRGPLVDETALLETLNRGGIAAAALDVFETEPLPADSPWRTTAWGKDGRSEVLLTPHMGYVDEQIHGWYEEVAQNLERWLNGQEFTVRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1B3</accession>
    <name>A0A8G1R1B3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_397444</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515345.1">
        <property type="nucleotide sequence ID" value="XM_025657023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1B3"/>
    <dbReference type="GeneID" id="37160425"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF1">
        <property type="entry name" value="NADP-DEPENDENT MANNITOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH57423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="276" mass="29587" checksum="2D96562F692DFE46" modified="2022-01-19" version="1">MSMSVAECAPVREGYPRPFPNTPTNVLAQMRLSGKVVVITGAADGIGYAVAEAMAEANADIAMWYNSNDAAVAKAQALASTHGIRATAYKVDVSDADAVQQAIADVAKDFGKIDVFIANAGMAISKPLLEQTLEEYRKQMSVNVDGVLYCAKYVGEVFKQQGFGNLIITSSMSGHIVNVPVDQPVYNGSKAFVTHLGKSLAREWREFARVNIVSPGFFDTKMGASPQTVNEAYRMAPLGRQGHVKEIKGLYLYLASDASTFMTGSDVLIDGGYVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R295</accession>
    <name>A0A8G1R295_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-amino-acid oxidase</fullName>
            <ecNumber evidence="8">1.4.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_448728</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-alpha-amino acid + O2 + H2O = a 2-oxocarboxylate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="EC" id="1.4.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21817"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.3" evidence="8"/>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516628.1">
        <property type="nucleotide sequence ID" value="XM_025660002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R295"/>
    <dbReference type="GeneID" id="37163404"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000018">
        <property type="entry name" value="D-amino acid oxidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF16">
        <property type="entry name" value="D-AMINO ACID OXIDASE (AFU_ORTHOLOGUE AFUA_5G11290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="11">
        <location>
            <begin position="5"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="46"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH58706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="364" mass="39620" checksum="CD7C96291AF9BE39" modified="2022-01-19" version="1">MANNRIVILGAGVSGLTTAYLLSQDASNSITVLAKHMPGDYDIEYTSPWAGANYLPVGKAGSDHERWERNTWPTLRELTKNHPEAGIHFQETIVYNRTKDQGSATGEWFSELVQKDPWYMEVVPDFQDIPADQLAPGIDNASKFTSVCINTAVYLPWLVGQCRKNGVVFKRAVLKHVADAAKGHHTGQKADVVVNCTGLSSKKLGGVLDDKLYPARGQIVVVRNDPGKMVSISGTDDGEDEVVYMMTRAAGGGTVIGGSYQKNQWDPLPDPNLAVRIMKRAIALCPELVEKGQGIEGLDIIRHGVGLRPLREGGPRIEAEKVDGVSVVHNYGHGGFGYQASFGCAEDAVKLVQETLRRKDKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3D5</accession>
    <name>A0A8G1R3D5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_274547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516334.1">
        <property type="nucleotide sequence ID" value="XM_025655133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3D5"/>
    <dbReference type="GeneID" id="37158535"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="187" mass="20554" checksum="24065DC4F8067AF6" modified="2022-01-19" version="1">MLRYTGLGSLSNALDRVGASGLDLDTTKYQMKGIKCTYHSKPEISGVIPGSSVETVRNVSDLSVKQTSERRSFFGEIGDSGSSHVSCAGHNLRDIERFGSAPLSEMLLLAYLDPRHADSSRCISQSALPKAVQIPDLSQDFMSGQHTQWALCRHLKQTLKPTSFRKMNPCLVGRLLAKIEYSSRLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3J5</accession>
    <name>A0A8G1R3J5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_285502</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515774.1">
        <property type="nucleotide sequence ID" value="XM_025655236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3J5"/>
    <dbReference type="GeneID" id="37158638"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH57852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="394" mass="45258" checksum="2A0202C21DC366AE" modified="2022-01-19" version="1">MSQNRPGVFSSLRMGEVVREKVQDGLTGETKEISYSQCKIVGNGSFGVVFQTKMMPSGEDAAIKRVLQDKRFKNRELQIMRIVRHPNIVELKAFYYSNGERKDEVYLNLVLEYVPETVYRASRYFNKLKTTMPMLEVKLYIYQLFRSLAYIHSQGICHRDIKPQNLLLDPNTGILKLCDFGSAKILVENEPNVSYICSRYYRAPELIFGATNYTTKIDVWSTGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPTREQIRTMNPNYMEHKFPQIKPHPFNKVFRRAPHEAIDLISALLEYTPTQRLSAIEAMCHPFFDELRDPNTRLPDSRHPNGSTRELPNLFDFSRHELSIAPAMNSRLIPPHARPALEARGLDITNFKPLTKEEMIARLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3L8</accession>
    <name>A0A8G1R3L8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PX domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_448998</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515804.1">
        <property type="nucleotide sequence ID" value="XM_025660067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3L8"/>
    <dbReference type="GeneID" id="37163469"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF47">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 122 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="5">
        <location>
            <begin position="166"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="520"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="688"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="715"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="775"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH57882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="999" mass="109159" checksum="B7D80B047745F808" modified="2022-01-19" version="1">MDETSNWAEQSQPKKPELAETSNIGLPTSYNEQAATESLDPVRSKGVIESTLQFLSTANSETLLGVFACLVVATLVLFGRLGLLLIGIASGIILHAQWEAVYEDPIHPLSNPRQRRRKELALDITRRLLDWPKSTTLAADAEQDDTGQVFLFGDSSSADLDYSALGPKTADALRSITDAAMKDYVISWSSPILPPETTFHLACRKLLAEFISSLSLHLSRKRSADTFLELLTNSSSLIIVFLNELSAAFESVGSTKPPEEVVLRYIETSPESGLANILANDQQKKKLDIIADDILARFLDPNVYGCLLLRNFMREMFVSVLFESTVSSLSRPEIINGWIIYLFSEGKSEIMTAIDAGVEGAQEQVVTATRELNSVNELPSDTTSNTSPDSDIPGDIIQHEMANVDRATVEAKREAKRLSDMITAHDQQKQSPERALGDYVQEVASDDRIDHREVLPADEIGDGALQRKVSDRDQAKHIENNIDSKLEENNSSSPSLMQSKSPTAPTSLPEPAILHRASITVETEASKVTSKGPLRSKPTSDYLLQVEPVSTRSTGWMVFRKYTDFESLHQTLEAISRLHKLRKFSDDHPVVPSWKGQTTLELAKNLECYLQDALNHESLAESEKMKRFLGKDEHLGSDFSNPYGRTGFPFPSQSALENVGKGVLGVLSNAPRGVSGSGKAMLDGMTGVFGGGSSKKPSPDSVVGDKARPLDPVNHNGSIDQGSQGRLRNSARIGSASPPDGSHRDKTFGRPAPPPEEAFPNQSDTATDYAGFPDSSAQTTDVGSTVASTQLSPSTGRNTSADLPRSPGGTQDNSHANSEGQAPDAGLSEYRSRGNPITHEETRIAVELIFAVINELYTLSSAWNIRRTLLNAAKSYILRPGNPHLETIRELLQVSMIDSHTSDEAIGLYLNKLRENALPTESELENWPPPSTDAEKERLRETARKVFVQRGLPQALTSVMGANASKEVLGRIFDCLQVQNLARGFVYSLFLQALKTAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4K8</accession>
    <name>A0A8G1R4K8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_369524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516994.1">
        <property type="nucleotide sequence ID" value="XM_025655927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4K8"/>
    <dbReference type="GeneID" id="37159329"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="149" mass="16309" checksum="ECE35B64C3362DE1" modified="2022-01-19" version="1">MSSFTQPVPVVACGRIPAMGKSISQHLLPEYEVIHFILSYEAAEAELPHLLAGRDPQSRSPNEIGTHDYSRPPRAVIFGRGYEPKQVEELKQKFAGVTKEPVAWVRGNPADLPAGAAGPEYAQNVAADMKKVLKKWRDGGGKGEEILVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4U2</accession>
    <name>A0A8G1R4U2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_450223</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514752.1">
        <property type="nucleotide sequence ID" value="XM_025660329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4U2"/>
    <dbReference type="GeneID" id="37163731"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000266">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="72"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="520"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="603"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH56830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="615" mass="68031" checksum="303088EA04C369EC" modified="2022-01-19" version="1">MAGDNLPSDGEPAMPNRISYWRLLLDQGVLTQEILDYPWEGSGTDDDPYLVTWIPNDPRNPMNFPAWRKWLYTITVAWATLAVSLVSSAYSGGVEQIMESFHVGTEVATLGISLFVLGFAIGPLLWAPMSELWGRQYLFFVSYCGLTAFNAGITGSKNIETLIILRFFAGAFGSSPLTNAGGVVADLFPAKQRGLAMSIFAAAPFMGPTIGPVCGGFLGMNAGWKWVMGFLAAFSGLLWIIGSLVVPETYAPVLLQQRAKKLTKVTGKIHRSKTEAEKGKVPYSTVFKTALSRPWVLLFREPIVLLLSVYMAIIYGTLYMMFAAFPIVYEELRGWNQGVSGLSFLGVMVGMNIAVWYSIWDNKRYERTDEAHKGFAPPEARLPPCLMASVTIPLGLFWFAWTNYPSIHFMASIAACVPFGFGMVLVFLSLMNYLIDAYTIFAASVLAANSVLRSIFGAVFPLFTTYMYHNLGVHWASSIPAFLALACVPFPFLFYKYGPAIRTRCKFSAQSDAFMRRLMEQSTRDNRQPEPEKDITEKETEEKETEVSPVQASSSTLGEKSRLGDLPAVTAEDAARTRSIASQGSRRPGSAKAESVYEGNPYDVDRVNTRDSFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4V5</accession>
    <name>A0A8G1R4V5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_244029</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517436.1">
        <property type="nucleotide sequence ID" value="XM_025654865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4V5"/>
    <dbReference type="GeneID" id="37158267"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH59514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="17572" checksum="9A65102A3112DFA9" modified="2022-01-19" version="1">MSNTMAQPAESSVSYDLTRKSHMGGDCILKRFAQWFWSVWMIAGSGTHDALADPANHPKATNGASTKTNGCAGTARGGLSTTGECDTGLREQSSGNEHSYPCKACQTWGVVCDQQRPRCSHCLDQQILCFYVAPLPKPPKRSTKSRSRHVEIVNSSPRLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4W7</accession>
    <name>A0A8G1R4W7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_517733</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518068.1">
        <property type="nucleotide sequence ID" value="XM_025664929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4W7"/>
    <dbReference type="GeneID" id="37168331"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020608">
        <property type="entry name" value="RNA_pol_subH/Rpb5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007129">
        <property type="entry name" value="PRK09570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01110">
        <property type="entry name" value="RNA_POL_H_23KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="6">
        <location>
            <begin position="162"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH60146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="235" mass="27262" checksum="69A1B403A296048B" modified="2022-01-19" version="1">MDEDYSAGSVDADREMTRLWRTWRTVFEMLLDRGYEVTEDEVQMPLHEFKQKYSDPLGYPDRNKMKISARPTEAMQAKYTPLPSKSNPNPQPDCGTIYVEFCPDSTGVGTKQVRTFNHFVDENNFHTGVFITQTPISPSAVRLLSSMPGRICEHFQEQDLLVNITRHELVPKHVLLSPDEKARLLERYRLKESQLPRIQVSDPVARYLGLRRGQVVKIIRRSETAGRYASYRWVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R565</accession>
    <name>A0A8G1R565_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_448296</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517324.1">
        <property type="nucleotide sequence ID" value="XM_025659904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R565"/>
    <dbReference type="GeneID" id="37163306"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000001">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158472">
        <property type="entry name" value="HAMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="50"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="142"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="234"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="326"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="418"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="492"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="868"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH59402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="991" mass="108229" checksum="7DEE6C2517361301" modified="2022-01-19" version="1">MINQLRVFASEVSRVAREVGTEGILGGQAQIAGVHGVWEELTKNVNIMALNITDQVREIAAVMAGVAHGELSQKIERPARGEVLQLQQTINTMVDQLRMFATEVTRVARDVGIEGVLGGQAQISGIQGMWNELTVNVNAMAHNLTTQVRDIATVTRAVANGDLTQKVQADCRGELLALKEIINSMVDQLRQFAQEVTKIAKEVGTDGVLGGQATVHDVKGVWKDLTEGVNQMAMNLTTQVREIAEVTTAVAVGDLTKKVTADVKGEIADLKHTINGMVDKLNQFAFEVSKVAQEVGVDGTLGGQAVVVNIEGKWKDLTTNVNTMAHNLTLQVRSISHVTQAIASGDLSKKIEVHAQGEILTLKNTINNMVQQLDRFAQELKRVARDVGVEGKMGGQANAVGMCGRWKEITQDVNIMADNLTSQVRAFGEITNAATDGDFSKLITVSASGEMDELKQKINKMVSNLRDSIQRNTAAKEAAELANRSKSEFLANMSHEIRTPMNGIIGMTQLGLDSEGLTPYIREMLNVVHNLGNSLLTIIDDILDISKIEANHVVIESIPFSLGATVFNALKTLTVEANEKALELSYCVDGWVPDFVIGDSFRLHQIILNLVGNAIKFTEQGEIQLTVRNAAKDNFSSTDYMLELLVSDTGIGIDNAKLDLIFDKFQQADGSMTRRFGGTGLGLSISKKLANLMGGDIWVSSLMGAGSTFHFVFKVKLADTSYGDMKKRLEQYADHKALLVAVNGHGDSNQIIQMLKELNLNFVIVYPGAQGEGAWDTEVALTNSSQYDVLIVQNMESLVNLRTLDEFRFAPAVLVGPSMPVSMKAAMDLGVTSCVIRSGLTIDFGHGLLPVLEGCSTRLSTRQTNPLTILLAEDNEVNQKVAVRFLEKHRHHITVVDDGLEALAKVREQKYDVILMDIQMPNMGGFESTVRIREYEEEHALSRTPIIALTAHAMFGDRDKCIAAGMDDYLSKPLNQNRLIQMIAKWAGMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R570</accession>
    <name>A0A8G1R570_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc metallo proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_517849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518218.1">
        <property type="nucleotide sequence ID" value="XM_025664942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R570"/>
    <dbReference type="GeneID" id="37168344"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="2">
        <location>
            <begin position="641"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="789" mass="86695" checksum="C5B9400CB1363C05" modified="2022-01-19" version="1">MPLFKQLRRRSKANFHPSKSAPEKQSNESQSNGDMTSGKSSSTLETASYSSLTPPSSIKPTLSSPNLPSLSESNGTSNNAVSPLSAPPQRPGLLTAPSQRNSAYFGSNMSVNGAVRSPTPSSPYAPRIISISDNSWVHQKVLLVYGQIGDPRQHPLDGTVTVSHHQDSFPSVPWPVTSAHFKTLVHLVPGPNRLRFDFVTAKHSSGSAHQTVHTSYICINYLPLVNTPPLHLVVLLGKDSDGTFDAVPERQQREGNGLETAIQKYRMAAYLWQAFTSEQMFRNNFGRRCFRFEEEWQAGTLSRRDAINGQMRNEAKVHVVRTDKTVAELRDLNLAQQNDSATHKDELFRIARDAVKDHFRLRPGQKQYVSVLLLDSHWDVGTQTITGHAALGSGTGDLKLAIFGSHSLQSYPTSLEDVVDALSDCTRTDTDYVANDSGEGGSSWEAANIGIGAHLHEVGHLFGCPHQESGIMLRDYVRLNRTFLTREPFATRTKTQGLKLCLPQDECSWHRLDALRFRFHPCFRLPGDAPVGSDDSVSVWPVENGKIVFTASTGIAFMELYAEGDNVCHSFIEYLNSESSSNGLPRQVTVTESELRQRVYGTEKEKKKSIRVVVYSGALGSHNIDSVSNLKSKQNLVKLPKSHTGYRGNKVGLSQLEGSEPEQLLLDCASASSTKILTSIRIYHDNALYGLEFFYEDATSQLFGNRGGKPDDFVLDTRRGEIILGFYVRAGAWVDGIEILTSQGRKSGIYGNASGGSGYTLIPPLGYKIAGISGTSGPWIDGFSLLRCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R587</accession>
    <name>A0A8G1R587_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_459187</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515897.1">
        <property type="nucleotide sequence ID" value="XM_025661635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R587"/>
    <dbReference type="GeneID" id="37165037"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001166">
        <property type="entry name" value="WD repeat protein (AFU_orthologue AFUA_4G09620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="209"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="283"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH57975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="476" mass="51552" checksum="90B69A905C714439" modified="2022-01-19" version="1">MNAYLLNRVLGSISPSTFHVAQTTRLVQQLEPAPGIRFSARRDILLEGSQEDAGLIFDDEVFAHKAGVNVLAIDHYDGRFMVSGGADPSIRLWDLESRGSELKHVHQSVASVNRASHEDAHTRAITSISIYPFDPTPSTILTTSYDGTLKLSALAPAAITPVHTFNLDCTPYTHSLSSNSASPLLIAVGTSEKPVRLLDLRSGLSTHGLPGHESSVLSVSWAPHQPHILASASADNRVILFDIRRGGHNSAIAALDMDDAVGLVRPGSTPASYQSRPAFSPHARAHNGAVTGVRWTSTGSHLVTAGQDSRIRVWDAGTGANTLVHFGQRVRNSVSSHLAERAPLVIPRGVVTPGQETLLWPNFNERDDRGEIFMFELREGAFVKLLRVPGLVTGRQQFQGRSSALSAARINALAWRGNGASGEGIEMFSAHGDGTIRTWASREPEGEPDDEAEEAERADRKRKRDVLDEIYRGFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5U7</accession>
    <name>A0A8G1R5U7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_486296</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517760.1">
        <property type="nucleotide sequence ID" value="XM_025663380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5U7"/>
    <dbReference type="GeneID" id="37166782"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="13">
        <location>
            <begin position="56"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH59838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="221" mass="25013" checksum="E0D70156F00C5CE0" modified="2022-01-19" version="1">MGSENPSNPLWTTQSVLASLPHPPEENSASPIPFFHLLERLKTTKREGWRRFGINSGESISDHMYRMSVMTMLAPPTLASRLNLPHCMKMALIHDMAESLVGDITPVDRVDKTEKARREAAVMDYIANNLLGGVPGGMLTGQEILKVFNEYEANETLEAQFVHDVDKMELLLQMVEYERANNIDLTEFCHVANKVQLPETKEWAATVLQEREKFWKSKATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6Z2</accession>
    <name>A0A8G1R6Z2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_457275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518360.1">
        <property type="nucleotide sequence ID" value="XM_025661501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6Z2"/>
    <dbReference type="GeneID" id="37164903"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010424">
        <property type="entry name" value="EutQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169:SF1">
        <property type="entry name" value="ACETATE KINASE EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169">
        <property type="entry name" value="ETHANOLAMINE UTILIZATION PROTEIN EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH60438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="117" mass="12763" checksum="DBB1F4EF36261A85" modified="2022-01-19" version="1">MVLQVKSNTAMYNVPRYGDIPNIFFGTASFPPTIIDQTLTADIADLLGTSKSGEKNPIVGSWFRIEKGPESTPPTYSYDEVGVVIEGEINLRDETGQTVTVSYGLAWKCGGREMAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7N8</accession>
    <name>A0A8G1R7N8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_467634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH60012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517934.1">
        <property type="nucleotide sequence ID" value="XM_025662201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7N8"/>
    <dbReference type="GeneID" id="37165603"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050135">
        <property type="term" value="F:NADP+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053024">
        <property type="entry name" value="Fungal_surface_NADase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025331">
        <property type="entry name" value="TNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42059">
        <property type="entry name" value="TNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42059:SF1">
        <property type="entry name" value="TNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14021">
        <property type="entry name" value="TNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034120575" description="TNT domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="TNT" evidence="2">
        <location>
            <begin position="124"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="240" mass="26686" checksum="88D904CAEE26C42E" modified="2022-01-19" version="1">MVILARVSLLLVPLLGTLSHAIQAEDYPSTCVDACDGIEPDPTDTNYYCDYCICKNKLLGWSNFQPTDNFTDMFTDWVPLGGLCPKDWLCTWANWTDNGFNPTYSKLVYPPNNGFNGCPKNVSLGVGTLVDRFGTQNGSYLAPADAPYAQRSIGPSSLNKYNGSTMYNYWRFNVTEEFVALGGEILPWYGQPGGGWQWYANVTQLQIDGKLKLVGATTFEVNEAWEAAGPMERVYGLQDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7P8</accession>
    <name>A0A8G1R7P8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HLH transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_110801</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519538.1">
        <property type="nucleotide sequence ID" value="XM_025653850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7P8"/>
    <dbReference type="GeneID" id="37157252"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11399">
        <property type="entry name" value="bHLHzip_scHMS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000116">
        <property type="entry name" value="Putative HLH transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019006">
        <property type="entry name" value="Sre1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09427">
        <property type="entry name" value="DUF2014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="168"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="868"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="868"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH61616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="986" mass="108668" checksum="B6DC42D91681DC9F" modified="2022-01-19" version="1">MALPTMGSDFQLFSPLQSSERRDSQADSTAFAQSTTEDSSQDWTQWMRWDDKGFADGAKDVSQSPFDTTFTSPNASIGNTDLFQKSDFSPDINLDCTNIPFDSLLDQNYGGVCQSKIGSIGTDLQSALSATSGSPLSSEGTARKRKSGSDDDGSTVSGVVPTGKKMPAKKRAHNVIEKRYRANLNEKIAELRDSVPSLRASKNASGSLMDDDDEGVTPANKLNKASILSKATEYIRHLEIRNKRLEDENMALKNRLRQAEKAVDQSLTSAASVSSPSNYTVSTESGASSSPSVFSHVEDSPSDHSPTSLYPPEGLLKVPDAFRRMREESNAKDNAFSQSYIQYPSSNNNVSSPCGGRTRRSYYPNKYMLGALAGLMIVEGMGSEKKTESTAKGLLAMPMNLFGNLQATLQSPTAAYWLVMARNFWYSWHARAISHFLILATLVVGSAFIVFVYLFNATPGEQSSSLKTSSPSDTSSNFRRQAWLTSIQRVGVPRHRFFHEWYVVTSRCFEYVLRCLLGWKLYSSITGVTEEDEKGRVKTWDIAIDAQLAGGDAEISKSRLVLTIFAAGTLPRSPMRMMLKALHCRILLWRVGDRGSWSFDLSNDVARSLARYQWDLARTMHKAMPKDHPDALPSHLAALLQLDCDEVMIDSIVQRAANLTWNRPTQEGTDDDQALLDVVEEDPAIQSSLDALAAWWSSHLLQRALLRYFEASSGGPDAKKSRDLFKAKIKLALDVAPQPSAAHTRALVMKAVFFEQDRAANIGTVLAALPKDKGRSKQNQASNFLDSSLPVSVREEIAISVRCAMIAAIFTARTTGDTSLPASFTIQRAVTWFNQLPLDPVDLTLLGFASVYHLLHVLASDTDYLSSSESSSPSSPASRSSTPSSSLSSDEEENDKPRVSQKPEILPQSIPNLGRVASELMYWARNAYNPAFYGFTSQLVKVIETECTSLCHSAGVDVTDYSCIQEEKIKSKQLKDKKKKKYPRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7S4</accession>
    <name>A0A8G1R7S4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane ATPase</fullName>
            <ecNumber evidence="10">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_238979</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518689.1">
        <property type="nucleotide sequence ID" value="XM_025654818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7S4"/>
    <dbReference type="GeneID" id="37158220"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="737"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="764"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="798"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="866"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="915"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="75"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH60767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="990" mass="108953" checksum="62C1D143B7D0B145" modified="2022-01-19" version="1">MAERRISYAPDVENGDHSRAPQLDDGAGLDEYAALNRYISTAPDKRRGSTASAGGVSAGKKKKGFSLFGKKSDGVEEGFVCPDDWLETDMRSGLRSSDIEPRRKRTGWNELTTEKTNFFVQFIGYFRGPILYVMELAVLLAAGLRDWIDFGVIIGILMLNAVVGWYQEKQAADVVASLKGDIAMKAIVIRDGQEQEILARELVTGDIIVVEEGTVVPADIRLICDYDKPENFETYKEYLATVGDDTLKEKEDEDDEDGGIEARAGVSLVAVDQSAITGESLAVDKYMADTCYYTTGCKRGKAYAIVTATARHSFVGKTAALVQGAQDQGHFKAVMDNIGTTLLVLVMFWILAAWIGGFYRHLKIATPENEDRNLLHYTLILLIIGVPVGLPVVTTTTLAVGAAYLAEQKAIVQKLTAIESLAGVDILCSDKTGTLTANQLSIREPYVNEGVDVNWMMAVAAIASNHNIKNLDPIDKVTIMTLRRYPKAREILARNWVTEKYTPFDPVSKRITTICTCDGVRYVCAKGAPKAILNMSQCSEEEADKFREKAAEFARRGFRSLGVAVQKEGEPWQLLGMYPMFDPPREDTAHTIAEAQHLGLSVKMLTGDALAIAKETCKMLALSTKVYDSERLIHGGLAGSAQHDLVEKADGFAEVFPEHKYQVVEMLQQRGHLTAMTGDGVNDAPSLKKADCGIAVEGSTEAAQAAADIVFLAPGLSTIVDAIKLARQIFQRMKAYIQYRIALCLHLEVYLVTSMIIIDETIRADLIVFIALFADLATIAIAYDNAHYEQRPVEWQLPKIWVISVILGILLAAATWIIRASLFLTNGGIIQNFGSPQEILFLEVALTENWLIFVTRGGKTWPSWQLVGAIFIVDVLATLFCVFGWLSGDYLQTHPVDRADFSINGDVDIVTVVVIWGYSIGVTIIIAVVYYLLSSIPFLDNLGRKTRSRADTQIENLLGHLSKLAIEHEVDAHGKSRYMLGARAEVEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8M6</accession>
    <name>A0A8G1R8M6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO85DRAFT_518149</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518553.1">
        <property type="nucleotide sequence ID" value="XM_025664952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8M6"/>
    <dbReference type="GeneID" id="37168354"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="39"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RAH60631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="372" mass="40031" checksum="1E1E60C39E03902D" modified="2022-01-19" version="1">MFRQSIRRFGTTALRAAEASTTSYNVRVSKAQGFTNGLTEAIGNTPLIRLKKLSEETGCNILGKAEFQNPGGSVKDRAALFVVEDAERKGLLKPGGTVVEGTAGNTGIGLAHVCRSKGYKLVIYMPNTQSQGKIDLLRLLGAEVYPVPAVAFDNPQNYNHQARRHAESLDNAVWTNQFDNTANRQAHIETTGPEIWAQTNGQIDAFTCATGTGGTLAGITRYLKTVSDGKVKSFLADPPGSVLHSYIQSGGNLVERSGSSITEGIGQGRVTDNLQPDIGLLDGSLNIPDEKSIEMVYRCLDEEGLYLGASSALNVVAAQEVAKKLGRGNTVVTILCDGAYRYADRLFSNTWLQTKGLRGAVPKHLERYVVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8M7</accession>
    <name>A0A8G1R8M7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_446479</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519245.1">
        <property type="nucleotide sequence ID" value="XM_025659511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8M7"/>
    <dbReference type="GeneID" id="37162913"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH61323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="420" mass="46769" checksum="1A28E8882C325E4B" modified="2022-01-19" version="1">MASQVSVSSPAPKPKIDLSKKLSELRASKAKSQTPSSREPAPVTPPLPSAPDLSSHQYARPVRRILSKQDHDLFLSSSTHTLILAFIFGLSDSVRGRATTEIGSPSPIITKIQSIVFQIRSLLETHPSLDQGGSRFGNPAFRDLFDDVATQSAAWHKDILGFQDQALIEEASTYLINSLGSRDRLDYGSGHELNFMMWLLCLRQVHLFSATDFPAIVFHVYVSYMNLMRDIQTTYYLEPAGSHGVWGLDDYHFLPFLFGASQLVAHPYITPLAIHNMAVLEEESGKYIYLDQVRWVDSVKTVKGLRWHSPMLDDISGAKNWSKIESGMKKMFAKEVLGKLPIMQHFLFGSLLPAAPGMREITDDMEDDEHDHEHGHDHNHADHTDYFGDCCGIKVPSTIAAGAEMRKRGGGSGLRPIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8T6</accession>
    <name>A0A8G1R8T6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_255160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517892.1">
        <property type="nucleotide sequence ID" value="XM_025654970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8T6"/>
    <dbReference type="GeneID" id="37158372"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="316"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="705" mass="78279" checksum="76A479D62CB32D1D" modified="2022-01-19" version="1">MPYTAPLKTSPSAQHIEHSELTPQSCPSSPTAVVSHHQRQHLPRSYSSTSYVRRHRRSPSSSKVFVFPEPEAHIKVDHVNDPHASIRTSPPPISDAVIPPGALISPPESANNSSDEEVSYPSQDGLQLKKLEAAVRSIEQRRVSSPERQLSEVQSSSSMAAIAGGPVQPPRPPLSREARKISHSRSVTETSIDRRQEEALTSSPEESDRDDEPPVRHPMVRKKSGELVRPALRPPSARRRPSSMPGTPTYAKAVHFDAQLEHIRHFLQLDKPQAVSADTSPVEDYDAAEEFPFKKGHRDMPAFEWELGLSNFPKDSPSRAKQRVRLERLHLSSDKNTMIGVVGVANLAFHKHVAARFTLDHWKTVSEVSAEYNDDPRRKPTQDGYDRFAFSIRLDDQANLERKTMFVCIRYNVAGEEYWDNNNSQNYQVNFRRVQKEMPQARAPPSARPRTNLPRSRSFAGSNSRPHSMPPSFDALSEMDKYISFGNPPTNGKKEHLGDDDPHDVEMVAPIRRDKQNHQVFGNRYDFEASLSAAMRTKPTHDRTTLTARAKSKLPSHGSHGHSSERKASHKEENAPLPSRGSQQPGSSDHHKPSTIVSGKPHRESSVYKELVDKYCFFGSGSMNYPSGAVGPVTGSPDYEIRTGSSSSSSSVSPCSSPPMDGVYGGDSRHSPAAPSSPNHIGYPYLQPMQNSFMKDTQTPAIIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8X1</accession>
    <name>A0A8G1R8X1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">pectinesterase</fullName>
            <ecNumber evidence="5">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_416565</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in maceration and soft-rotting of plant tissue.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="5"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518688.1">
        <property type="nucleotide sequence ID" value="XM_025657737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8X1"/>
    <dbReference type="GeneID" id="37161139"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000045">
        <property type="entry name" value="Pectin methylesterase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF137">
        <property type="entry name" value="PECTIN METHYL ESTERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034031228" description="pectinesterase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="11">
        <location>
            <begin position="171"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH60766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="399" mass="43316" checksum="3AE2F8FE3F7BC7FE" modified="2022-01-19" version="1">MLLHGLLLALQAILASSAAITSPSSNHLSTAAREKCQTTLQCPPGTIIVSNTNAHSDISNFTTLQAAINALPNDNSSQTILLLSGSYNEQVNITRAGPITLLGQQPDRAALTDPARNTVNLTFAGANSDSSGNIDNVWFSVMVVAPTLDASLTGSGTTGYPVPADTPFGNTNFRVYNIDFRNTYAPYSAGPAHAISFSRSNGGFYYCGFYSYQDTIYIGKLGSAYMYKSILAGQTDFLYGFGTLFIQSSQIILRSCGGGITAWKGTNTTVRNNYGVYIHDSTINAANSSIAEQIQGSCALGRPWNSLHRSIFANTYEDGSIEPSGYINWEDRWSKNETLMAEYRAFGPGFNLTGREESEVSVLLSSSEEERYRDPKRVFLFEDGREGNVAWIDWDVVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R981</accession>
    <name>A0A8G1R981_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylation factor GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_135261</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520348.1">
        <property type="nucleotide sequence ID" value="XM_025654032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R981"/>
    <dbReference type="GeneID" id="37157434"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07608">
        <property type="entry name" value="BAR_ArfGAP_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000051">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000252">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000017">
        <property type="entry name" value="ARF GTPase activator (Csx2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="626"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="808"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="533"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1048"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="586"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH62426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1119" mass="122531" checksum="7D0629AE57E6A22E" modified="2022-01-19" version="1">MGNVGSRLDDSGNLYFKDQTRFTIASVTITNSKRRVLLSLVPNSFPATRYAAKRETGDDSPIEYIQDPDVSPSAPVPTFLLRLNNEDELNFNFTFILRQTQTGTAANSTVNGVSTSLPEVADTVLTGLTFAHAPNSRELDNLITREFHANPNLQNNSNVQLVGDYSTAGSPSVQFDWSWKWKPPKAVEDKGGGWRNSCSFLDYDQRANRLNTLAHFSFWVHNTVRSLPSPQFSSPNLEVNVPFRNRIPSSQSVLSHSSDADAASNSQNVPVTPPEAGDTTATLPHVSAPPPPVKVDLPHSRPGEDMSVVEDGPLFRATMKALEQKTGNMRAKIKKVLKKAEAAQQAQTACNEAVEAFLNALKEASTSNANAIQPALDHYFERTAVQILNYERLNTIQLQRLVIEPLVKLYNNDIKQAEAKKKEFEEESRDYYAYVSRYLGQRQDSLKEKKRVESDSKYQAKRRNFELKRFDYSSFMQDLHGGRKEQEVLSHLTKYADTQAKSFLAAAKQVDDMVPQLDALIHEVNQADKEFQFQRTEREEKRRNLEKSSNMYIEPDSLANAGASSVHSGNGGGNPKSENELGRADSTGSQLRGVISNSSSILPQTNSGSHSGGPSMLASTSSSTGQQRKEGLLWALSRPGSHIDPKGINKQAWHKFWIVLDQGKLSEYSNWKQKLDLHMDPIDLRMASVREARNAERRFCFEVITPQYKRIYQATSEEDMANWIRAINNALQSAVEGRGMSPPPVSSGNDNASIGRDIGSVLTGKSTSYTVQHSQSTGSNNSVTRRTTVGARPSYVRGDGLGFEENPSKLLQTIRDADQGNNWCADCGSTSKVEWVSINLGIVLCIECSGIHRSLGTHISKIRSLTLDVNSFSNDIVEILLQIGNRVSNMIWEATLDQAQKPVAASTREQRLKFITAKYSERAFVQPLPSPLSRFTTSDETLLAAIKRNDIQGVLYGIALRANVNITDRSRSTHAIFLALAAADPASPGAASNLSVKPSGAPTVKAIPFPIAELLVQNGAEIPSQPPPIPLSSAAQLYLSQRTARVSAFGTPPAAPSPGKATSDSLGSGPAIRGAGNDHVIPTTQAPSSIDSKEREKLQKRGSAGARFAGKVASLGIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9B2</accession>
    <name>A0A8G1R9B2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_435305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518898.1">
        <property type="nucleotide sequence ID" value="XM_025658515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9B2"/>
    <dbReference type="GeneID" id="37161917"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH60976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="169" mass="17277" checksum="7C346106B13291F9" modified="2022-01-19" version="1">MLSFIPPALILIHEAAKPTTSHISKAPASSSSQETAPALASTRAAFSAERTSAPIWGASAATAICARPFGTGVKARTVHVGLTTCDTETLIADLAKVALRIVVAERGGYSFRSRVADSFDIGSVVATNVTAQSSNQAAGSIFTVGCGNFASDILGESSGSDYAGQNENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9X6</accession>
    <name>A0A8G1R9X6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxymethylbilane synthase</fullName>
            <ecNumber evidence="4">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_389165</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="4"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519905.1">
        <property type="nucleotide sequence ID" value="XM_025656735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9X6"/>
    <dbReference type="GeneID" id="37160137"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="10">
        <location>
            <begin position="12"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="11">
        <location>
            <begin position="246"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH61983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="346" mass="37914" checksum="EADB0004F340BEBB" modified="2022-01-19" version="1">MSQITPATVQELRLGTRNSKLALVQAEHVSKELTRAHPGVQFPWQTVVVRGDADKSSPFLKFAGPSDAAKNIWTEEMETKLCAGELDLLVHCLKDMPTRLPENCTLGAIVYREDPTDALVMKEGLRSQYTDLSQLPPGSVVGTSSTRRKALLRYRYPHLKVEECRGNLGTRLRKLDDPEGPFSAIILATAGMVRINLEDRITQRLPPSEFPYAVGQGALGIEIRKQDTQTETMVRKIEDLLTRRICLAERSLLRTLQGGCSSPVAVQCTVEQAPTASSAARLRLDGTIIHPHGTTLLSERTTAEVGTDEDAEALGATVAQLLLKNGGQALLEEIRLLQETISTDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA19</accession>
    <name>A0A8G1RA19_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">3-ketoacyl-CoA ketothiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_446390</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519149.1">
        <property type="nucleotide sequence ID" value="XM_025659492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA19"/>
    <dbReference type="GeneID" id="37162894"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF10">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="11">
        <location>
            <begin position="32"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="12">
        <location>
            <begin position="295"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="8">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH61227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="418" mass="44290" checksum="98BA341D5FF0A943" modified="2022-01-19" version="1">MAADRLNSILSHLKPSGNSGLAAITQKNPDDVVITLALRTPLAKAVKGGFKDTELDYILYALLKEVLSKSKIDPALVEDVCLGNVGDGKAAYLVRAASLAAGIPHTAGGSSVNRFCSSGLKAVQDIANQIQLGAIDVGIAVGAELMSAGGDRLPRPFNEEVLRNQEAADCMQPMGQTSENVGADFNITREQQDKYAAESFRRAEEAQKAGWFDDEIVPITTKVKDPKTGEVKQVTLTKDEGIRYGTTPESLGKIRPAFPQFGNRSTGGNSSQVTDGAAAVLLMRRSKAIELNQPILAKFCGATVAGVPPRIMGIGPTAAIPKLLSQFNLNKDDIDIYEINEAFASMAVYCLNNLGLEHAKVNPRGGAIALGHPLGATGARQICTILSEARRTKKKVLVTSMCIGTGQGMAGLFVNEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAT2</accession>
    <name>A0A8G1RAT2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neutral amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_465584</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519554.1">
        <property type="nucleotide sequence ID" value="XM_025662068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAT2"/>
    <dbReference type="GeneID" id="37165470"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF668">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="52"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH61632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="457" mass="49896" checksum="93B808DCA3EB72AA" modified="2022-01-19" version="1">MEAVHDSPPPYATDGIDEKKEDISQVEQNLKPGLEESDAFGNEEFAEIKYKTLKWWQCGLLMICESVSLGVLSLPAAVATLGFVPAIILIVGLGILATYTGYNIGLFRERYPHIQNLADAGEILMGPFGRELFGLGQFLFCIFVMGSHLLTFRVMMNTITEHGTCSIVFSVIGMVISMVLSIPRTMKGMTWISFASFLSIFSAVMITMIGVGVEKHPGRIIEATVDTNLYTAFTAVSNIVFAYCAHVAFFGLIAEMEQPKDFKKSLFMLQTFEISLYVTAACVIYYYVGKDVQSPALSSAGPLLKKIAYGIAIPTIVGAGVVNGHIGLKYIYFRTCSKSGLIHSRSRRSVLVWIALGLACWLVAWIIAEAIPVFSDLNSLISALFASWFSYGLSGIYWLHLNYGQWFASPRKIALTVLNAGIAVFGLVLCVLGLYASGTAIHNDANSNSFTCANTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAW7</accession>
    <name>A0A8G1RAW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_252758</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517812.1">
        <property type="nucleotide sequence ID" value="XM_025654948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAW7"/>
    <dbReference type="GeneID" id="37158350"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH59890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="340" mass="39758" checksum="6C4B102149119CA6" modified="2022-01-19" version="1">MTTSPPAQPPDTTTTPTSPTPDTTTSNEPTNAHPRPTKFRFKDPSRKRHRHHHSSSHKKNPQRTPSPKRKKHRAPHRRKHTISPPPSPSQTTSRFSPSTAFRESLFDALGDDEGAAYWESVYGQPIHTYSVPEVPRGPNGELEMMDEEEYAAYVRRKMWERTREGMLAEEERMREERRRVKEKERRKERERGEWERAVEESLRRGRERKRRRGWRGVWGRDCACWGELDGVVRGGEDGGGGKRFEEVVFWPVESGERRDVGRKEVEEFMRECARVVDEDGEDKDGDGLLGLLKTERVRWHPDKIQHRYGKLGIDERVLKSVTEVFQIVDQMWSEERKKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB76</accession>
    <name>A0A8G1RB76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1479 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_360949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520871.1">
        <property type="nucleotide sequence ID" value="XM_025655572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB76"/>
    <dbReference type="GeneID" id="37158974"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="456" mass="51122" checksum="80324C1A834E8763" modified="2022-01-19" version="1">MTKAAGDISSVFPSLRPDYKPEPLPPRFRDLKLKYFEKNEKALKDSWERLLPSLEEEVHKIKAKGSDIIPSVQYSDVVNGTVPDHLLAEIRHRGSVVIRNVVPREKALDWKERIKDYAAANQERVKAFPPDSPAVYELYWTPSQAEARAHPSMLGTQRFLQRLWHSSDPNTPISTRNPLTYADRLRIRQPGDAKFTLGPHIDGGSLERWEDPEYSRVYSKILEGKWEEYDPWDAKHRVSANMDMYNGAGSCSMLRFFQGWLSMSNTAPGEGSLHVCPMVIQSTAYTILRPFFDPVSSQPLLDNTFPGAVPGTCQEYNPVTHPHLDLETTMVSVPEVEPGDYVAWHCDSLHSVDKEHRGKGDSSVLYIPATPMCEMNVNYLLKQRQAALAYSPPWDFPGAGGPGEIGFQGALDWSSVDAEGLRAMGMGSQPWEITDDMTEGEKAVVRAANKTCFGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBG6</accession>
    <name>A0A8G1RBG6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_456059</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519914.1">
        <property type="nucleotide sequence ID" value="XM_025661422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBG6"/>
    <dbReference type="GeneID" id="37164824"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF160">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="22"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="475" mass="51732" checksum="4158F5187C4D8D85" modified="2022-01-19" version="1">MHNGPSSPNDPKYWSTRVRCAILMNICFYVFIGNLYAAGLSTGFASLAQDFHVGFDTLTGLVAWPVFALGISNLFWMPTAMCIGKRPVILISMIVFLAGCTWSIKTSTFKDLLASRIMASFGAGSIEALGPSIIADLFSERYFATAMALFALSLCAGSQVGPMIAGFVIDDKGWRWFFIVCVILGAVNFLASILFLPETTFRRCFAEDGNGNAAERENEPSPRNYWKDLISFRDRGLEPEGLKCWPGQFSLSFRFLCVPIALFATIAYGIFLSGIVLISAISPQFLSAPPYHLSSSAIGVYTLSSFLGIVIGYPIAGPLTDLLSRLVATHRRNTTTTINNTHHPKDRMPALIVPFLIAPPGLILFAYAIAREKSLYVSATGYAMQAAALVFVPSVTMSYIMDVYPQSGSEAMVLINAGKNVVAFGVTVSGAGWVGREGIVRVFWELAAVQWVVLALVVPLYVFDGVVRRFAGRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBM0</accession>
    <name>A0A8G1RBM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_362263</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519989.1">
        <property type="nucleotide sequence ID" value="XM_025655621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBM0"/>
    <dbReference type="GeneID" id="37159023"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF2">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="287"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH62067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="952" mass="108181" checksum="DAA4DB5D437325F8" modified="2022-01-19" version="1">MSIKRALSKIVPNKSSPDDESSHSTPASAASMSPRRSILSNFLRDRDYASSSDDGSDDSSSPGSISKNQQKRLARKQRKEKSRLSEERHSDESDSRRKEEVANATREETSEMKARYGELPLIQSRTRPREVRTNLDAISESLVGQQICFTARLHIIRRMSAKLVFLVFRQQLLTFQGVLHEEAGVKSIAMIHWAEHLRLGSIVRVRGTIQKPQVPILGCTIHDVEISIDELHQVVRREEPVPFSIYEAEIQTAEEERIEGRRSHIPDRVRLTNRLLDLRTPTSQSIFRIQSAICNLFRFALDEQGFMEIHTPKLQGSATESGASVFHVQYFGRDAFLAQSPQLAKQMAIAADFGRVYEIGAVFRAENSNTHRHLTEYTGLDIEMAIEEHYHEMLEVLDAVIKSILQGVYGRYRREVETVKHQFPSEDVVWLEKTPILRFSDGIKMLNDSGWRDEDGNPLPEDEDLHTRDEIRLGELVKEKYGTDYYILDKFPASARPFYTMPDPEDDRYTNSFDIFIRGQEIVSGGQRIHDPHMLEENMRRSGIDPDTMEDYMEGFRWGAPPHAGAGVGLERLLMLLLKLGNIRLASLFPRDPRSFPAKPVAAQLRHPESSTIDPPWARDRKGAIAQDTSQLQPLEHLIANYGDATSTSWGDERFKIWRDMGTGAAISYVPSSSNYVIIPGNPLCDPKQYRQVITQFLQWLRRETKYKPVWLLCSAEVETILGERMGWRTLSCIAEERVNPARNMAASDGEIARKIRHAESEGVKLVTVNRGEMVSDEVRQKIDQRVQDWLNNRKGTQVHLSEIRPWRDPEHRWYFYAVDKEGTICAFVALATLAPVHGMQIKYSFDFPGSPNGVIEHIVTHAIQTAAAAGVKSFTFGAGAMSSLTPGHNLRGARIKMLQHTYDTMAKQFHLVRKSEFRAKLGAEDDPLYIAYPPHGLGSKGMRAVLHFFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC48</accession>
    <name>A0A8G1RC48_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_132007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520259.1">
        <property type="nucleotide sequence ID" value="XM_025653997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC48"/>
    <dbReference type="GeneID" id="37157399"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="79" mass="9059" checksum="B56E3191502C7EB0" modified="2022-01-19" version="1">MRAMPHTFATLPAAPAIACSPMMRNCWKLRLQLCDCRIPVNLSQLLCEKRSPFREVRVLTGQMKFTCKVQSLDDNAEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCG6</accession>
    <name>A0A8G1RCG6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BO85DRAFT_444611</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521240.1">
        <property type="nucleotide sequence ID" value="XM_025659058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCG6"/>
    <dbReference type="GeneID" id="37162460"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF6">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY PROTEIN (CEFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="20">
        <location>
            <begin position="26"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="21">
        <location>
            <begin position="467"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RAH63318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="601" mass="66736" checksum="74DFCBF2B81334DA" modified="2022-01-19" version="1">MLAQRRSLRDTAKAAAQGQLSMWPVFAATASQYPDMVCIWTREQSYTYREALAAAARYGHFYLSKGVQKGDLVAFYLQNRAEFIFAWLGLWSIGCAPAAINYNLTGDALVHCLSISGAKLLLVDPEAGCMARIEERRSTIENELGMQLVTVDDTFSNHLLSFPASVPRDGQLTSHVPGEFPAILLYTSGTTGLPKGCAFTTSRLYAAQTIRNSNITNVSGPGGDRWYSAMPLYHGTSAIAMINNIVGGRSIAIAPRFSVRNFWPDVRASQATVFVYVGEVVRYLLAAPPSPQDREHGVRMMYGNGLRPDVWERFRERFGVAEVGEFFNSTEGVFGLFNLNRGPFTAGAVGHHGLLLRTSLRNTYVPVVVDAETGDAVRDEKTGLVKRAAYDEGGEILVKVPDEKAFQGYWRNEAATKKKFMRDVLTKGDLWYRSGDALRRDGDGRWYFLDRLGDTFRWKSENVSTAEVAQVLGRYPGIQEANVYGVKVPHHEGRAGCAALLLSPEARSGFDGQELARFARAQLPRYAVPVFLRVVEQSWHIHNHKQNKGPLRQEGVEPGKLGSKVVQGHRDRLFWLPPGSEGYIEFGEKDWQRLAGGEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCS3</accession>
    <name>A0A8G1RCS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">dUTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_444028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520604.1">
        <property type="nucleotide sequence ID" value="XM_025658927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCS3"/>
    <dbReference type="GeneID" id="37162329"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002598">
        <property type="entry name" value="PRK02253.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42680">
        <property type="entry name" value="DCTP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42680:SF3">
        <property type="entry name" value="DCTP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22769">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH62682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="185" mass="19975" checksum="E65BC3AB99E6B06E" modified="2022-01-19" version="1">MILSGLEVVTRQLMRNLRGATQQQPCGVDLTLRQISKWTSAATIDFDNTKRQAARTSILPFDNASHAITLPPGAYLVDFNQTVHVPRDCMGSIFARSSLWRSGVGITAGVVDAGYEGALGALMEVKNPHGVVLYRDAKLAQIVFEELSEEVEGYNGIYQASTSSVGRDGTGQTSNTQAGDTILER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD16</accession>
    <name>A0A8G1RD16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_465301</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521359.1">
        <property type="nucleotide sequence ID" value="XM_025662046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD16"/>
    <dbReference type="GeneID" id="37165448"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH63437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="574" mass="65445" checksum="C4F06ED5A4988811" modified="2022-01-19" version="1">MNVQDEKILRYLSAVSTQALRNGPQQMLHCPPGNSQHRDREIYITYLIIATIGICLMNYWYGIHALHEKPRVKRGMKIPPLVPSLIPPLGTLPLGMLWNPRGFVLSAKHLLWNSRPVRARILTQTLYIFQGTETIGSILKERSLSLFAVHAILLRRVFGLPPSALRIYAHDNSGGFPRPYPESNVKPQNRIEYLIRRTNQRLLLGAGFAPFVKRFQSTLTERLQALHIRSHWVELDDFVQLFNNDFTASMMDALCGKYLIRQHPNFAINLITLDDNVLKMLVGVPRFLAPRAYAARDAALGALKDWNTWAREHFDPAAVGSDGDDPVWGSKYWRDRVDAFQQIEGFDADVIAMHDLAVIWGMTTNGINTSFWTCLEAFKDQELLNLVRAEARACLISESDVKFDIDRLLHQPVLQAIYAETLRLRINGFFVWYQSRGDLNVDGWHIPNKNWILTTPMAGHMDPEIWCRGAAADHPVEEFWVGRWLKYADDGQTLLFTTEMAKGAWMPYGGALHVCPGRYFAKTMIILGMALMTTLYDCEVLADEKNLRMSMRTFGFGTVGPVGKVPVRIRRRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDX1</accession>
    <name>A0A8G1RDX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_516124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519417.1">
        <property type="nucleotide sequence ID" value="XM_025664829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDX1"/>
    <dbReference type="GeneID" id="37168231"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034964035" evidence="2">
        <location>
            <begin position="26"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="143" mass="15349" checksum="6BC9B5706F679E2B" modified="2022-01-19" version="1">MWSRQITVQKVFVLASVLLASGVSAAAIPASLPDPASVSVAPTNTQVPTGQGDVSPASISYEGVPDCQSCREGEDNEQTTDESTTQVKRESQHIAARTETKQLTPEEEKAEEEGVKKLKEEAFEKCHGSAGCETFYILLHLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RE69</accession>
    <name>A0A8G1RE69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_433960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521369.1">
        <property type="nucleotide sequence ID" value="XM_025658439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RE69"/>
    <dbReference type="GeneID" id="37161841"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="122" mass="13771" checksum="FDE03048AA8B0E6B" modified="2022-01-19" version="1">MTQAPQSRKPPMMYHISTHPSIHLIESSSSRMQVSVAKRARARPKQSKAKQSTVTVLSHIPHAYLPNIEQSSTYVYVCTFLGEGVPGILFIGWVACSVFNDLLGTKIVRWMWIVRVYLKNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RGT3</accession>
    <name>A0A8G1RGT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sister chromatid cohesion factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_433594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520962.1">
        <property type="nucleotide sequence ID" value="XM_025658427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RGT3"/>
    <dbReference type="GeneID" id="37161829"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF3">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="273"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="843"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="947" mass="104654" checksum="99D5A4C49FD7C3E1" modified="2022-01-19" version="1">MPLIASPAPFPSSAPSPESQKRKNEEQSQVEEPKRQKIMGGFLDEADDDDDWDAFNDAQLRSEFQVQEDIIQQPPVELPEIPRPSQVPTESTPKPASTAPDLDPTPVPEPSTITSLPSRRPYRSIQIKTCSGKTHHVSLKRPAPRVSYERLVAGRSVTAPGRAQKSYYGIDIHKLLDEAANEPEAPPAETRPAPVVQPSIEAPIHDQKSAKLAAAMWTEKYRARKFTELIGDERTHRSVLRWLKAWEPIVFPNIARAKAKKPFNGKEEEERTHRKVLLLCGPPGLGKTTLAHVCARQAGYEVLEINASDDRSKDVVKGRIRDSLGTENVKGMNVEVGEEKVRKAGRPVCVVVDEVDGVVSGSGGGGEGGFMKALIDLVLLDQKNSSGATEQTKGRKKKGDNFRFLRPLIMVCNDVYHPSLRPLRAASVAEIIHVRQAPLENVVTRMKRIFTVEGIPSDNDGVRRLCEASWGLARRKQGGVKSSGTAEGDIRSVLVAAEWVAHKLRNECPSTLRLTRSWLEQKVLSANSSGSAFFKGLNRGGVRDLIERVFTEGAGFTDAPVGVDSFRDPFSNSEDKVPVGVADLRKRHAIERLREMVDASGEHDRAVAECFASYPLQSYQDDTFLSKPNAAYDWLHFHDTMSSKVYTAQDWELSAYLSQSVVAFHHLFATAQGKAKPREVDDEEEEHPFSGPRADFAAYEAQKQNRAILTEFQSAFSAPLSRLFRSTDSLVIDLIPNLVRMLSPDVKPVVVRGSGEQRSVASVRKESERTLIQAAVRVMAGLGVRFEKVRIENAGAHGGWAYRMEPPLDTLITFSKTKSTPTASGSAPVRYAVRQVLDQEYRKENIRKQSETLTTSNIGKKSSGKTANGQSKDDGDAKKTAHGPNVKRDFFGRVIKEPTPPPSDESPETAKQNETLKAGRRVWVTYHDGFSNAVRKPISMGELLAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VH57</accession>
    <name>A0A8G1VH57_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_524792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VH57"/>
    <dbReference type="GeneID" id="37168841"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH51892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="212" mass="24966" checksum="7BAC9EE7F2C3FC67" modified="2022-01-19" version="1">MSLPAPESTKFPFSPRPDSVDAYLAEQGMLSVSEQRINDVLTQSGIRAECIYLPQHLSRILPSRLIHVVSRIRFEAYKAIMIMRICNSWYRRRYENLHPDDDSPFLQRHIQSVQLLLGWDKDNKPVKDQPIAVADQKIPEGSITLGSHRRRYTAYKDFHDEMVWNFRVGVYYARLFIYHKLATKYFNSHLPSDVLPAFNAWKQEIFIRRPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHT4</accession>
    <name>A0A8G1VHT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_472556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510474.1">
        <property type="nucleotide sequence ID" value="XM_025662562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHT4"/>
    <dbReference type="GeneID" id="37165964"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="127" mass="14542" checksum="8A4A03032BD92CB4" modified="2022-01-19" version="1">MVVALADMATVGAETAMTAHARYRWFKTRHHSFSGSGETKMQERHLSQCELSLHTQKRHQRMDQGYLENAIEETRQIGNKRAMGSQRDRQISTRKGLFITIHAKLPRMRAEGKRGLFRTDGINSSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIH0</accession>
    <name>A0A8G1VIH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_452305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512273.1">
        <property type="nucleotide sequence ID" value="XM_025660792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIH0"/>
    <dbReference type="GeneID" id="37164194"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="129" mass="14631" checksum="D087AD2B8D83646D" modified="2022-01-19" version="1">MYQFDLWWPDLAMLEASIILVNKRDSNLASGTVPMSLTFPSDTSTEVVDAELLRQMLRMLITARHDADDAQTTDEGGDDSTPMTNWIRIREGRKYDRSPASSGEQIPEVELVWGDTGFRLGQKRVRQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIW3</accession>
    <name>A0A8G1VIW3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_452460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511987.1">
        <property type="nucleotide sequence ID" value="XM_025660825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIW3"/>
    <dbReference type="GeneID" id="37164227"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF8">
        <property type="entry name" value="DUF4220 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="461" mass="52432" checksum="CF5345E9AAE7D39D" modified="2022-01-19" version="1">MSTNSTFTAAIVDGWIDEPDGRGTWSILSSCLLTIVLCCWTAVMPNIPARSDRWYHGLRDRLHLASLGLLGPEFLLMLALGQWSSARESVKGFEQLLTTKTTKRPLWTLTHAFYADMGGFLIDGPGTDRPFPVNAKQLQFLIEKGYVDYPMIAEDDINDRNKSDAFSRVIAVCQALWLLVNCAMRVAQGLALTTLELTTISFVVVFLVTSFCWRFKPSDISSTLTLHANTDINIIREQHCPYPSQEWHETPLDFVCDDVSFCAVHWHYYTEILRKLHIPMFSRPMTAKPRDRIVSDNFPVTDLKADCIATPVLLVFGSMFMLAWNFHFPSPVEHLLWRIASIYNLIFTVIGGLHAGYCDKILLPREYKRRMVLPLSRLKTSTNPSRQRSCLRNLAAKLRNIDPYRNPKREVPLRVLFPTSILCAAYCVGRAYVLTEDFIGLRSLPASAFQTVSWSDYVPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ85</accession>
    <name>A0A8G1VJ85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_451512</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513083.1">
        <property type="nucleotide sequence ID" value="XM_025660604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ85"/>
    <dbReference type="GeneID" id="37164006"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000005">
        <property type="entry name" value="Proteasome subunit beta type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024689">
        <property type="entry name" value="Proteasome_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12465">
        <property type="entry name" value="Pr_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <feature type="domain" description="Proteasome beta subunit C-terminal" evidence="12">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH55161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="272" mass="29392" checksum="53EC72D05864EDF0" modified="2022-01-19" version="1">MTGFDFSNYNRNAALHAKGVPLPKATSTGTTIVGCIYDNGVVIAADTRATSGPIVADKNCEKLHYIAPKIWCAGAGTAADTEFTTALISSNIELHSLSTGRPPRVITCMTMLKQHLFRYQGHIGAYLVVAGVDPTGIGLFTVHAHGSTDKLPYVTMGSGSLAAMSVFESTWKPNLDREGAIALCAEAIKAGIFNDLGSGSNVDVCVIEKDKPTQLLRNYIKPNERGEKERNYRFPKGTTAYLNQKIISKEDMRKYISVEEASGDPNLMEVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJM7</accession>
    <name>A0A8G1VJM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hepatocellular carcinoma-associated antigen 59-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_521950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513518.1">
        <property type="nucleotide sequence ID" value="XM_025665225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJM7"/>
    <dbReference type="GeneID" id="37168627"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010756">
        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07052">
        <property type="entry name" value="Hep_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH55596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38055" checksum="76B0B2BB0AC7F52A" modified="2022-01-19" version="1">MEPEIDPASLFRPGKRRKFQRRRPEDNDEESPSATEDVARVSESSTPPSWQDAPSSVPTAEILRSRRLQRARKGGIEFSATSRPSAGKNSQTAISTVAEEDQENERLRAMCDRFTAHTGQTVDVDKHMMDFIESEMAKRYRRDNSTEVTTHDTPSATEPKAAALSSADLPQREPASLGKLHEIDLGHETTLQNIARTEAATKRLAGDGDQSSPTEQSSGPKMAPVNGDQKTWRNRKRRTSEDIERDRLVEEVLRESKLDVYEGPEEEGDEAVGEDGQAADDRVAEQFRRDFLDAIQSRRRVARARNTKTTKPEAPRGPKLGGSRSARAAMREMQEKSTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJP0</accession>
    <name>A0A8G1VJP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_470462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513563.1">
        <property type="nucleotide sequence ID" value="XM_025662398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJP0"/>
    <dbReference type="GeneID" id="37165800"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH55641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="133" mass="14508" checksum="505BE5CCF8E22EA7" modified="2022-01-19" version="1">MLDDSGTTAPGHHPSFYSLPLEQRSSRSSRTLTIHPLTQKGKDIVLGFKSGCTRSFLAVGQDSSSSATTFFISVRFESDQFIWAAFLAYRPDTLKIHAPNNSWRITYLCIQSSMMVVVGASGDRTSDGNGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJQ1</accession>
    <name>A0A8G1VJQ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_402657</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512842.1">
        <property type="nucleotide sequence ID" value="XM_025657195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJQ1"/>
    <dbReference type="GeneID" id="37160597"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="243"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH54920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="464" mass="51762" checksum="06CEFB638A62BF04" modified="2022-01-19" version="1">MSTLEDLDDLEREQRDKKKDQGDDGEGRKPEGEGDAEMKDADAKKDEDDGLLDEEILSSSTADIVKRRRMLENELRIMKSEYQRLTHEQNTMREKVKDNQEKIENNRQLPYLVGNVVELLDLDVEAEAAEEGANIDLDATRVGKSAVIKTSTRQTIYLPLIGLVDHEKLKPGDLIGVNKDSYLVLDTLPAEYDNRVKAMEVDEKPTEKYTDIGGLDKQIEEIVEAIVWPMKEADRFKKLGIKAPKGALMYGPPGTGKTLLARACAAETNATFLKLAGPQLVQMFIGDGAKLVRDCFALAKEKAPSIIFIDELDAVGTKRFDSEKSGDREVQRTMLELLNQLDGFASDDRIKVLAATNRVDVLDPALLRSGRLDRKIEFPLPNEEARANILQIHSRKMAVDDRVNWAELARSTDEFGGAQLKAVCVEAGMIALRKGMSKVGHENYVDAISEVQAKKKDTNMGIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKI1</accession>
    <name>A0A8G1VKI1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GPI transamidase component Gpi16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_402316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513249.1">
        <property type="nucleotide sequence ID" value="XM_025657185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKI1"/>
    <dbReference type="GeneID" id="37160587"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034920949" evidence="3">
        <location>
            <begin position="22"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH55327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="593" mass="65726" checksum="448145A5CDD91717" modified="2022-01-19" version="1">MTVLSLLTLLFVVALSSFTSATSDYHESLYLQPLPQSSLLASFNFRGNESQKSFDERHFRYFPRALGQILQHANTKELHLRFTTGRWDAESWGPRPWNGSKEGGTGVELWAWIDAPNDEAASAKWITLTQSLSGLFCASLNFIDSTRTTRPVASFELMGDHPASSNLHLLHGTLPGEVVCTENLTPFLKLLPCKGKAGVSSLLDGHKLFDASWQSMSVDVSPVCPQPGECYLHVDQTVDIVLDIDRSKRPRGNPIPRPVPSDQLACDTSKPYRSDDTCYPLESTSEKGWSLTEIFGRTLSGACPLTDNASQEPVCLRVPHEREVIVTPGAVETKRPDGFTRCFTLEPSTPFDLTIPEQEVTTHVPLDEPVLSAERTIVGHGQERGGMRIIFDNPSASNSVDFIYFETLPWFLRPYVHTLQASITGRNGLRQQVPASQFIRESFYRPAIDRERGTQLELAMTIPPASTVTLTYDFEKAILRYTEYPPDANRGFNVAPAVIKLDAANGQNHPIYIRTTSLLLPLPTPDFSMPYNVIILTSTVVALAFGSIFNLLVRRFVTAEEASALTAQTLKGRLGGEIVALRDRIKGKTAKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKP7</accession>
    <name>A0A8G1VKP7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_40703</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514688.1">
        <property type="nucleotide sequence ID" value="XM_025657350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKP7"/>
    <dbReference type="GeneID" id="37160752"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000007">
        <property type="entry name" value="Lysosomal beta glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000009">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051915">
        <property type="entry name" value="Cellulose_Degrad_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620:SF117">
        <property type="entry name" value="BETA-1,4-XYLOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620">
        <property type="entry name" value="PERIPLASMIC BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034962274" description="beta-glucosidase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="701"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH56766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="782" mass="85747" checksum="CDDEC9CE738A8A7A" modified="2022-01-19" version="1">MVAGLFAKALLLLQLGSGALAVQNVSRPLYKNLQAPVEARVSDLLSRMTVEDKMAQLMQGDIGNWMDSTTGAFNYTGLVENMEMKAGAFYIGYAVPWDWLATNIKRAQDYLLQNTTLGIPALVQTEGLHGFLLENATIYNSPIGYACSFNRKLVEKMGRLIAQEARAIGANQLFAPLADLARELRYGRVEETFSEDSYLAGEMAYHYIVGMQSLNVSATVKHFVGYSLPEQGLNTAPVQGGERYLRSTWLPSFKRAIVDAGAWSIMSAYHAYDGIPAVADWFTLTKILREEWKYDYYVISDSGATDRLCTAFKLCRSSPIDMEAVTTQALPAGNDVEMGGGSFNYQKIPELVESGQLDIEVVNTAVSRVLRAKFEMGLFENPYPAAPQSEWNKLIHSPEAVELARTIDKESIVLLENHNETLPLKKSGSIAVIGPMAHGFMNYGDYVIYGSQWRGVTPLDGIKAAVGDAATVNYAQGCERWSNDESGFDEAIAAAKKSDVAIVVVGTWSRDQTELWENYNATTGEHVDLDSLALVGAQGPLIRAIRDTGIPTIVVLSSGKPITDVTWIANSTSALLQQFYPSEQGGNALADILFGDYNPSGKLSVSFPHYVGDLPIYYDYLNSARNIGDAGHAYPNGTLEFGHQYVLGDPHAVYPFGYGKSYSSFEYGEVRLSKTNVSVSDETVVVSVEVRNLDEEREATEVVQVYVVDEIASVVVPNRLLKGFEKVVVPAGGSVEVEIEIKVKDLGLWDRKMEYVVEKGEFGVLVGSSSVDIRGRAAFWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKR5</accession>
    <name>A0A8G1VKR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-1,3-glucanase/mutanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_470262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513892.1">
        <property type="nucleotide sequence ID" value="XM_025662386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKR5"/>
    <dbReference type="GeneID" id="37165788"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF33">
        <property type="entry name" value="ASCUS WALL ENDO-1,3-ALPHA-GLUCANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034148893" evidence="1">
        <location>
            <begin position="21"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="994" mass="107568" checksum="82F56708C6352CF8" modified="2022-01-19" version="1">MRPFLPAILCLVLWSLEVHSRAVFAHFMVSNTLGYTVDDWQNEMLLALDANIDAFAMNIAVGDATNTQSLENAFSAAVNTGFSLFFSFDYAGNGAWAKDDVLDMLETYVSAKAYWRYDSKPFVSTFEGPDNADDWVDIKEKTGCYFIPDWSSVGAEVAVSLGDGVADGLFSWAAWPYGPSDMNTYVDASYIDFLDGKPYMMPVSPWFFTNMPGYSKNWLWRGDDIWYDRWVQAMFLAPEFIEIISWNDFGESHYIGPTLDADSSLAESTYTAFGTGQAPYNYALNMPHDGWRAFLPWLADTYKNNISTITQEGVQAWYRLNVRGSCTSDGGTTGNTVSQLQLEYWPYEIPQDRIFFSALLVSSADISVTVGGIDLGASWNSTPSGGTGIYHGSVEFSVQAGSVEVAITRGGDTIASFTGEDIVTGCAASSEIENWNAWVGSAMSATTISATPTYSLADEVCIRGWGVGNFNGLCSFACELGYCPVGACLCQEMGPQAKLPKSLGVIGYPAAGMTEDYSGLCAFSCNYGYCPSSACTTTEVALATSTVSPFTPNTCTSGEGTGDLTDVPPTANTSIYGYTMDAYTDSGLCDFACERGYCPSPVCSESVAGNGTDLVCTNDDPDSDCADDVEMCDYTLTFDSFASLKSSLSSIEDYCVNYYALGVLSDMLNNTMTNYTDIISNYGGKFTEYQEYIREEVPGELEDYMNPGGVGNAFFTCTFAQDGVNASTTTCPFDVEQLYNDYEIYYDLINATAFWANLTATTGIQKDWVQFGDKDVGSSCGVGSGKTCQPDKGVLKGYPLPADNITVTNPQTIIEDALPGIYNLTETIYLTQILSATGAYGGSMNDVLLTISTVVFTLAQAVANMGQVVEVADKASEEKKKAMIEEIIFGVLMVVPFLGEIRLISDGLEQLADMMSLIGDAGALGSTIYGVATDPDSAILDIFEIALMGGYRTPEEFEEAANARRALTDDEISSLGSDWKSCSDDLSDVRSVCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL68</accession>
    <name>A0A8G1VL68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_37623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515213.1">
        <property type="nucleotide sequence ID" value="XM_025656215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL68"/>
    <dbReference type="GeneID" id="37159617"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="281" mass="31084" checksum="8A6A30A63D73983C" modified="2022-01-19" version="1">MKSHSQRWVLRDTLITPADISLGSFIPNVTDLDLDILNDTISLSEHELSVSCTDNVTLSVCSHQASRLEVLIARLVGASSLSAQSTETHVLAKQSYLYTLRQPTQVFERACTSPAVRAWIQHQIEEGNRHRIYFVVGIRTVVDSTASVDRNDQVKRTADISLPDNILDSGLQALGGGVRVGGNRERGSGVSHQYSATGEQILALRLKRVRLRFFEPGGVDRARLERNTAWIMVSGNRTIQDDESEGVEADLDGAGETSETETMEVNFLGDDEEEEEDEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLF3</accession>
    <name>A0A8G1VLF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_449526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515453.1">
        <property type="nucleotide sequence ID" value="XM_025660180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLF3"/>
    <dbReference type="GeneID" id="37163582"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038906">
        <property type="entry name" value="TTC36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405">
        <property type="entry name" value="CDNA SEQUENCE BC021608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="28633" checksum="B57F6C4E46D24ECF" modified="2022-01-19" version="1">MTPNPTAKPNLTTNDSAVLQALFDAESSPSNSITINSSLPAYPAHLNITPELLQTLQSREVSIIRTLQSETTLDISTIQQAIKDLDTLIAQHPTYPSAYVNRAQTLRILIDKTNTTTESSGQDNDDDKIFAPENTEPASTLLADLGNAITLATPRSPADPVSTVQARLLADAHTHRGYLLLKAARVKKERKEGEIIGGPEQLRAVEPEQLEDMASRDFFFGGRYGNKVAQQLAVQTNPYAKMCGAIVKEALRKEVVGDDVVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLU8</accession>
    <name>A0A8G1VLU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_459855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515032.1">
        <property type="nucleotide sequence ID" value="XM_025661677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLU8"/>
    <dbReference type="GeneID" id="37165079"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="462" mass="50268" checksum="1F13DFBD478DFA65" modified="2022-01-19" version="1">MILPRDGYPRQDSSSSVESPSSGRDQIIIGVVFGGVAVIMIISAILLIRCKKRSNERRHRRQQQRLLAHHLSQSTTGYYQYHPDLEGSKPQTPEYPLEITSTTQQEPSSCLEQQQHHPQQRVIEDPPPAYQPLPVYDPSRYHGVDGMVGIAVPYPGVTASMYRMSGLGIEPQRRVPDRDSNAFSFAVEERLDVPVNRPGGEAEEGQSVQRPRPVLSRLVTNFGDHYAGPRAPSPSRRVDKLDGWFGPNRDDQPVIVAAASPLLLLQTCNATSELGAWHSSSRSLPHIDRDLAHAVTAERSIHLPEQGLPCVTPIPSLSQPLDGPRQGRTINYGCGWMSPTSRSLLAAPSGRLAAGCLQVDCAAQLFSRLLSPLLPSPGTRTGSAPCSRGSPMTSHCVGIVIPLTKQRAIPLRLTETSPTGRVRPTGLPTQGDKKSAVMEGEPFCRVQDVSARLSPSVPFAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMC5</accession>
    <name>A0A8G1VMC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_469001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515557.1">
        <property type="nucleotide sequence ID" value="XM_025662306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMC5"/>
    <dbReference type="GeneID" id="37165708"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF4">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="747"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="10">
        <location>
            <begin position="448"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH57635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="767" mass="83084" checksum="7C3905F903266A82" modified="2022-01-19" version="1">MADRQSVQHSLNSLLSKLSDPDPDMRYMSLNDLLGILNNPNSTYLAHDQVSSSRLAEGLLKALDDQHGDVQNQALKCLGPLVLRLPFESLASLLEKLTNLTASQTIDTSVPNTALRYIVTALPRPQPGQPPSQEATMAYSAVSRVLIPRLTGPTPSPTSRRGSIVKGMLEKDPSKGFSSDAIDVLIQVVTCFGPLLKEPELTALQNSVLSIVDNDTAGTVVTKRALTAISALVLHFSDAQLSAFVQGLVQRFNSPQLSTVHRRHLIATVGGVAKSAPAKFGPHLPTLAPYVFAAVGEDNLAQSHCLHYSTVYSGLHLTTIYYLKMHMLRLVVSGLGLVACTTARNIFSLQPNRQGTHLLPLTHGDAPDHKLVERGSSPRCGPDHGKCPEGKCCSTAGNHCSSPDCQIDFGNCDAHTTPGGPPTDKIPRPHVGNVPYGPKFIRSCTTPGTIALTFDDGPKEYTQDLLDLLDKYEAKVTFFVTGNNNAKGEIDSPGMPWASLIQRMYRSGHQVASHTWSHQDLSKVTQDQRRVQLLWNEVALRNILGTIPTYMRPPYSSCTAESGCLEDLGSLGYHVILYDIDTEDYSHDSPALIQQSKDIFDRNLASRTDFDRPWLVIAHDVHEQTVHNLTEYMLKKLIAEGYRAVTVGECLGDPPELWYRKDEAFDDRQTRKSKSKNDVAKTVSVDGMCGGNITCLGSRFGPCCSGTGFCGSMSTFCGSGCRPDNGGGAPNAGSGKPTKPAKSEGKALQLSSSVAIVILLFLVVLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMM8</accession>
    <name>A0A8G1VMM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_467682</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516803.1">
        <property type="nucleotide sequence ID" value="XM_025662205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMM8"/>
    <dbReference type="GeneID" id="37165607"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09080">
        <property type="entry name" value="TDP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034396162" evidence="3">
        <location>
            <begin position="23"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="167"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="5">
        <location>
            <begin position="804"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH58881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1056" mass="116204" checksum="FD184DE9BCCE3C12" modified="2022-01-19" version="1">MFVSLNVLVAPAVLSAAAVATGVPTIARAASDSRSDDTTVFFENDGNWTSHATKPSALFINTASSYADANAVCAAQNEALLSCDEYANLEKLFRYQQYLGRITTDQLFWSSCSSSSPTSWRGVVQSSTNSSSDLPFLCTNSAPLVDTVDTDYSGFPRVNVTYNGTTFEGMRDHMAFRFAGIRFAQPPTADLRFQPAQPWNHTISYVNATSYGPACLQFGYFDGNSYGLNPWGNSEDCLFLNIWTPHIPSADSLDPDNGKPVMVWIYGGGDTQGSAADSTFDGASLASRSDVVVVSFNYRLNIFGLLALNDGELNGNYMMTDKIQALRWVKQNIAAFGGNPKNVTIFGQSAGGSSVNDLITCPATIGEDLFQNGIVQSGKSNVATAEVAAAYALPYIERFCNGTATQRASCLRSLPAETLLDISNNSISWYTVIDGHYSADYTQARYALGAQYINSVNVLTGNMLEEYQSLATTTLWPSMSNFSEALEILINDAAINEAQAEAALNSGLYTITNNTVYNGSTTYTSVYNASVHLGTEGQLYCDGTLLQWIAAASWAFKSHWFYIHNRGYALSYYDFYDLCTFPVGKPDTPYYRCHSSDLYEVFGTYYIFDQPVRVPDDIYYTNAIHDMWGAFARTGNPNVDPAYLKARSYDSTIDFFFGFEWPQFTVNSPRVASLQYPGPQVSELPYQEHCEVLLPYVTNPSAPNATAHVLNNLRGSADCGWSVDCYNHHHPFHPNMDIFTRAQTSFLSWKHGTPLPSGAGASPKFQSWHTFDPVQSWIATRSDIDTSTPADPTGGADTSRLVLLTWNIDGTSPQTEKRVTEIITRIIGLDPRPDIIFFQEVSKPALQQILKDERVRELWLSSECDDTSWGDQSFAVMTLLSKARFTTNTAIGPIWRVKFPSHFARDALCCDIFVASSKEPSPTRLRLVNVHLDSLPIKPSHRPKQVSIVASLLRVAGQGLVAGDFNPVLDEDNSLLEKNGLVDAWTALRPGEPGLTWGLDGKQPFLPNRLDKIGILGLRPHDIKTIEPKPISGSSDDEPLWTDHHALVCSFGLVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN36</accession>
    <name>A0A8G1VN36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyclosome subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_468745</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516099.1">
        <property type="nucleotide sequence ID" value="XM_025662289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN36"/>
    <dbReference type="GeneID" id="37165691"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000999">
        <property type="entry name" value="Anaphase-promoting complex subunit Apc5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034082039" description="Anaphase-promoting complex subunit 5" evidence="9">
        <location>
            <begin position="23"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="10">
        <location>
            <begin position="268"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH58177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="773" mass="86825" checksum="72653AB5EC31DAFF" modified="2022-01-19" version="1">MSRYLTPSKVALLCLISIYTEGVVPNSSAIHILSYLVTCLSPLEREQSISSSGDQATQCSVSITDLKDKLTGHPSSVPGRTIWDLFLKKIWSLDCCDALEVFFADISAILAKTREEQIRDRDAGLAPDTGCMRLSRCSPLGVFVRRSQLEFTRLQFHDSVKLWRGFVKYRLPTYHVWARKNPSLEQAPVDINLLNLGLDTTDSLAQVAYGSIEDDSEDEQYVSTKDVERLLEFQISELQSLGGRVPDGMKAQLERIITSGVTVPNLVHYLRFLDAWRAGDYPSSFDNLHRYFDCTMHSRDRSSYQYALLNLAILQADFGCYGEAVSAMQEAVSIARESHDMNCLNFCMSWLYHFGKAFPEHMRDVQNTGMLGNEKEGLAFLKAKAKETEMWSLLSTTLLSEAKLEMRNGESLASSIENIIRASHLNVTKNLANSVGPQLLLQAALYSRIGITHLAWLSSETFRECYANKAPFEDHLKSTFRSCQLLAQQGRYTEVSARMNQISPDKLRSLKTYQYWTFFSGILQLQQQIYRDNRVAAEHLLAQLQAIQLPDNDITLLLSILTIDLRIRQGHYGGALELVEKAAQAIQQDNFDIFTQVKLLCLKASILQKTGHPQRGFSLAMRAASIAHRSRLLPSLWESICVLAGVLLSMREFDAVSELIESIMPQILETGDCSLAAQAYSLLVDANMGIAGSLWSEGQTNSVLRKEHVTRALGYLDCAYEQYEEIEDIKGQCEMVAKKATVMHLTGDPVLANDYAAKYLDLKRQARIDFGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN82</accession>
    <name>A0A8G1VN82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_487050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516234.1">
        <property type="nucleotide sequence ID" value="XM_025663428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN82"/>
    <dbReference type="GeneID" id="37166830"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000003">
        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="11">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH58312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="90" mass="10264" checksum="C6016D8DEB39487C" modified="2022-01-19" version="1">MPAYELRSGGDVKNKKQSVADLKYRRLTELNARLKEDLDRPRVKVSEAALSLINYCNNTRDFMVPSVWGQVDKREDPYAPQQQGGCCTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VND7</accession>
    <name>A0A8G1VND7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ACBP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_447640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517701.1">
        <property type="nucleotide sequence ID" value="XM_025659762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VND7"/>
    <dbReference type="GeneID" id="37163164"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="59"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH59779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="144" mass="15723" checksum="8C3320179877BD63" modified="2022-01-19" version="1">MSVPNFSAALDASIKKEKFTPEVQAAAAKVDSSVFSDAIKAVLGGDDTATVEGEQAVALKNAFEFAVAVVKMLKSEPGNEDKLALYKYFKRGNNQTPASPGMFDIQGKYKYNAWNEIKHISEAKAQAEYIKQVDTLIEKIGTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNG8</accession>
    <name>A0A8G1VNG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex protein EXO70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_467534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bud</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517791.1">
        <property type="nucleotide sequence ID" value="XM_025662194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNG8"/>
    <dbReference type="GeneID" id="37165596"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="5">
        <location>
            <begin position="246"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH59869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="631" mass="68882" checksum="FD474C029C97F108" modified="2022-01-19" version="1">MVAPRNAAYAEESAEVEVLYANLEKLKLLTKKIQGSLNRLETGGNVVKHAIGPIYSNTQSLQITNSNIDKVNEAIERLRQPLDAKGKEEGIIRSSPQTVGLSQYLSAVKRVEKALVDLNSTNLRSNQKAISEFTSLLVLGNSQLQDMLRGTLSDYVNPIEPLHYLTKELSFPSLPDETIAELGPVCSAIGSAASYGPQRGDGGNPALKIYADIRGPYITSSLQNLAIASLNTVKRRAADGPYRQGTNGIGIYSNALESFIYAEHDILVRVFTGDQRGLALQATCRSALGEYAQTLRELNQYIRANLMTDCFLAFEIIEIVTAMSYRVESKTGELKSLFIEALRPVRETAKSSLSELLEETKRKAAGITMLPPDGGSVPLVNEVMSSLTTLTGYSGPLASILTSLGDGNWRSTTNAAPTAPLDVSPDSMTLLSHFILDMIEALMIALEARGRALHRSKAVQGVFLSNVFCTVDRSIRQSSELARYLGSADSIARIDTFRKRATSTYLDAWKETSHYLLDVQYTSRGSGGSARPASGGVVDSAAIVKSLSSKDKDAIKDKFKAFNASFDELVGRHKALYMEREVRGVLAREVQAVLEPLYARFWDRYHEIDKGRGKYVKYDKGGLSAQLAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNL1</accession>
    <name>A0A8G1VNL1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glial factor naturation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_448739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516639.1">
        <property type="nucleotide sequence ID" value="XM_025660006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNL1"/>
    <dbReference type="GeneID" id="37163408"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000048">
        <property type="entry name" value="Putative gmf family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH58717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="141" mass="16252" checksum="706C2269CF642555" modified="2022-01-19" version="1">MSESRLYSFSPETKEKLRKFRLGTSRAKDPQAIIYIIDNKTQEIRPEDGEVYSKMEDVADELPESSPRFILLSYPLTLSSGRPSVPYVMLYYLPENCNPNQRMMYAGAVELMRNTAEVNRVIEVYEEDDIISIESKLQSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNP3</accession>
    <name>A0A8G1VNP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_519620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516729.1">
        <property type="nucleotide sequence ID" value="XM_025665070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNP3"/>
    <dbReference type="GeneID" id="37168472"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034379837" evidence="1">
        <location>
            <begin position="19"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="98" mass="10330" checksum="558B3C9DDF16FCA3" modified="2022-01-19" version="1">MKLLAVFGTLALSATANAAVTATCTPGLNYCSGVLEDVGSNGDAIEDALRRYGLGNNSGHTGLWPYYVFHCNNDHTLTVVEHCQLGCLNHGKGQNDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPQ0</accession>
    <name>A0A8G1VPQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPG20 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_415057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517987.1">
        <property type="nucleotide sequence ID" value="XM_025657671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPQ0"/>
    <dbReference type="GeneID" id="37161073"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="248"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="503" mass="52918" checksum="AA9B3E5F0ACC4286" modified="2022-01-19" version="1">MTSTVHDPRLLYSIGNIRAFHIQNGEETELTPSGPQTLSLLMVPTRTSSPGNSPSTPPPDASAEEDFYLHLHLPPELDLALPATTQIFHQSPDSYLIPRWDVGPDDGAFIRIQFPGIGSGPGKVTQDDIDTFETILAQCTAFLERAPPPSNHAPYNPATYAPGEGYVAPSGFAQDDTHGRIVLVDEEDGSIVGEMEGYDVVEKPGVKPGSKRPVEIELPTEAEGNQVNVSNVSEEYLRMARHPVYKDSTIVQTSATASRLIVTGSSYLANAITSGAEAFTKKTKPNPKPMTFSDTTHSRIRKVGTFSQGAAELSAKTVGQVGKYAQNIGASLARRRDNGTQRGVNGSGGDYKPGILNKSMIAFSTLTDGIEQGARNVLITGSNAASTMIGHRYGEQAGSVASDLTGGVKNVGLVYIDAAGVSRKAVLKSVARGMVVGRMRNGQQVLVGTGDGGDVPAGVAGPSQAYGREPVVRRQSPSSTPPPAYGAPGTTSLSGMSMSGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR65</accession>
    <name>A0A8G1VR65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_465541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519502.1">
        <property type="nucleotide sequence ID" value="XM_025662063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR65"/>
    <dbReference type="GeneID" id="37165465"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="2">
        <location>
            <begin position="355"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="623" mass="69967" checksum="022CA83ADECD85D6" modified="2022-01-19" version="1">MASEVLPQEFKIISSLRYDPALSTIGKRAATRTTPDPLTTPYYLLPYHQERLRNAAACFSWGKALAFLNQDTNQFVEFLNTFIPDNTKPWRLRILLDSAGTCEVEVNPTTSMNPLNYLTPTETNLQSTVWRVYIDSERISPSVFTTHKTTARDFYTAARLRSGIVSFVEPAEVLLVNPAGEIMEGSITTPYFRRRDTTDGEGKPAWITPPLSSGGNAGTTRQYALAQGFCAEDTIAATDLMDGEECWLSNGVRGFIRGQIYRQSTVEVMLVPLWSPNWVLTTTVKTKRTTKYYMMIGQTGDNQMMHRPIPALPNRLSGERPEADRNSSHIPNATLWCDFLIPIIRSTLYASFAIMKFFENVFTYDYSFPAVSLAYFLRYPNPYSRHVLTTDVIDRYVDPTTQRLHTTRLLLKKSKVPSGILKLLPKGIGGSDNSGQSYILETTVVDAKEGWMQTESRNMEWTGILSVVEKQFYQRQPEGPLGTLEGLSLDDKKSEQTTVRTTVTFRSKFGQGKLLGRRKTEPSSDHTGDYEEEAPKRGLFTSLSTAGIQRTIELIGLNRTRDAVLKSKQGMNVVLERLRNGGIVGVLEGMRQDREAAFGPEGGPWKRVWLSGHGHASIQDDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRB7</accession>
    <name>A0A8G1VRB7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_361867</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520673.1">
        <property type="nucleotide sequence ID" value="XM_025655601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRB7"/>
    <dbReference type="GeneID" id="37159003"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="14"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH62751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="579" mass="64120" checksum="EF240B2B9F982352" modified="2022-01-19" version="1">MENSFDYIICGGGTSGCVVAGRLAENPHIRILLIEAGQHNKDLENVHMVGGWSNLLDSTTDWNIVTPPMPNVNNRQVKLSRGKFLGGCSGCNGTLCIRGSKQDYDDWGLDGWSGKEFFKYMQKAETFHTKPWFKASDQHHGNSGPLHVEPHDLAPISERIMDSFVSQGLPLDPDMFTTGETPHGCGHVPRSVYNGIRTTSGDFVTNGYHRNNVTFMTDTTVDKILFKKTPSGPKADGVSVVTANGRRTLHAKREIIISSGSYCSPTILMRSGLGPKEELQRHNIECLVNLPGVGKNLMDHLIVFMFYETVKPGLTTDHHVYHGDSFDKTYALWKEKKEGFLSTFPFGSFAFARLDDRLKNEPLWKNAPRQPGRDPMGLTPNQPNIELFTTECYGGPKQYDQFPIDHKYAFSIIAELFSPRSRGSVTLKSKDPLEKPVVDCNYLADPLDLLVITEACRFANEIITKGAGTKDIVKGSWPPNLTHHTYTKREQWIPYVKEHATTCYHAGGTCAMGPDGDTNAVLDNKLRVRGVTGLRVADCSVMPTLNGGHTQMPAYGIGEKCADLVKETWASQALNVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRL5</accession>
    <name>A0A8G1VRL5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_510947</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the midasin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517810.1">
        <property type="nucleotide sequence ID" value="XM_025664569.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37167971"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000582">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001205">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001368">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001861">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002324">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21108">
        <property type="entry name" value="MDN1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="11">
        <location>
            <begin position="4703"/>
            <end position="4905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="4067"/>
            <end position="4553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4142"/>
            <end position="4168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4172"/>
            <end position="4197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4205"/>
            <end position="4219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4221"/>
            <end position="4246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4247"/>
            <end position="4263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4264"/>
            <end position="4304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4314"/>
            <end position="4366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="4406"/>
            <end position="4427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4458"/>
            <end position="4481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4482"/>
            <end position="4497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4529"/>
            <end position="4539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH59888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="4917" mass="548038" checksum="15EE5F42C963B054" modified="2022-01-19" version="1">[encoded data, 4917 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSA9</accession>
    <name>A0A8G1VSA9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase</fullName>
            <shortName evidence="11">HMP-P synthase</shortName>
            <shortName evidence="11">Hydroxymethylpyrimidine phosphate synthase</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_447179</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 2 Fe(3+) + 4 H2O = L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 3-oxopropanoate + 2 Fe(2+) + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65756"/>
            <dbReference type="Rhea" id="RHEA-COMP:16892"/>
            <dbReference type="Rhea" id="RHEA-COMP:16893"/>
            <dbReference type="Rhea" id="RHEA-COMP:16894"/>
            <dbReference type="Rhea" id="RHEA-COMP:16895"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:143915"/>
            <dbReference type="ChEBI" id="CHEBI:157692"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:65757"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the NMT1/THI5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518530.1">
        <property type="nucleotide sequence ID" value="XM_025659666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSA9"/>
    <dbReference type="GeneID" id="37163068"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13650">
        <property type="entry name" value="PBP2_THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000187">
        <property type="entry name" value="4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528:SF1">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SsuA/THI5-like" evidence="12">
        <location>
            <begin position="16"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH60608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="342" mass="38202" checksum="367515F6ECA20B2D" modified="2022-01-19" version="1">MSTDKITFLTNWHATPYHAPLYLAQSKGYFKEEGLKVALLEPNDPSDVTEIIGSGKVDMGFKAMIHTLAAKARNFPVTSIGSLLDEPFTGVVYLKDSGITEDFRSLKGKKIGYVGEFGKIQIDELTKYYGMTADDYTAVRCGMNVTKAIIRGDIDAGIGLENVQMVELAEWLAEQGRPRDDVQMLRIDQLAELGCCCFCSILYIANDAFLAANPEKVQKFMRAVKRATDYVLAEPARAFEEYVDMKPIMGTPVNRKIFERSFAYFSRDLKNVSRDWAKVTNYGKRLGILSSDFVANYTNDYLSWGLDADSTDPLGDQKRMAELQKKVAAEGGYKRLEVASEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VUT7</accession>
    <name>A0A8G1VUT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_444500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521095.1">
        <property type="nucleotide sequence ID" value="XM_025659026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VUT7"/>
    <dbReference type="GeneID" id="37162428"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="79" mass="8019" checksum="86CB366CE71A9941" modified="2022-01-19" version="1">MGSVVPCPLSMQAVLAANSAIAAPRAAIVAAQMHTVVLVSASRHLEAALSSQLVPMAFAALCPQIAPRAWAVSSVIAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QPU1</accession>
    <name>A0A8G1QPU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_432403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825089">
        <property type="protein sequence ID" value="RAH52016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509938.1">
        <property type="nucleotide sequence ID" value="XM_025658380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QPU1"/>
    <dbReference type="GeneID" id="37161782"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034670136" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11446" checksum="F9EA7D7D45F1A11F" modified="2022-01-19" version="1">MVSAKAIMFTMITAVMAQNKTQIGTTSEFRVCTVDARPIYSESCISLNQTGSTQFNVAVGCRQYGSTTCTGNYDTVGYRSDCYENSRFFQNFGTISGSIYCYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQ84</accession>
    <name>A0A8G1QQ84_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_431863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510178.1">
        <property type="nucleotide sequence ID" value="XM_025658349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQ84"/>
    <dbReference type="GeneID" id="37161751"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="262" mass="29167" checksum="54DB808221805702" modified="2022-01-19" version="1">MSAQLANLVGKKILAESARNHFGQEDPYFEEVPASRLNRAFGKKTQKRRKAVPPGLSQNDSKVLTQVKRRAYRLDLCLFSLCGIRFGWGSVIGLFPFIGDGADAALALMVVHTCDKIDGGLPSRLRMMMLMNIVIDFFIGLVPFIGDVADAVYKCNTRNAVLLEKHLREKGAKALAKQERRQDTADMSLPDEFDRYDDDTSGEPSSHKGQPHSRNTDGPAKPQASRDPKKSRSQGRWFGGRAQPDDDLETGVIDNSRPSRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QR27</accession>
    <name>A0A8G1QR27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_508049</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510005.1">
        <property type="nucleotide sequence ID" value="XM_025664436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QR27"/>
    <dbReference type="GeneID" id="37167838"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF1">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="407" mass="45509" checksum="673E3769D392250E" modified="2022-01-19" version="1">MEPVLIVGAGIVGLTLGQALQKANIPFRIHERDASPDARGQGWAITLHWALEYIQQMLPEDTLQAIQEVQVDPQVAKNDNGNFLFIDLATGEPKFKIPPSTRWRVNREKMRQALLRGIEQHVSWNSQVVDVDVKSDSTAAPCLVLADGTRVSGRFVIGVEGSRSLVRRVLRPDAYSNSVLPIRFTGVAVDLSPQEIKPLRSMDPLLFQGCHPSTGVFFWFSMLETPDKNGTRGTRDEHYRAQICMSWPVKSEVDEVAATDAERLENMKRRSVGFVPFLRSVVEGIPKGTPVVEIKLADWECLDWDNCDGRITLAGDAAHAMTMYRGEAANHGLLDAFNLFQALKKVYSGEKGAKDALDEYEAEMRLRTRRAVRLSRQACHDAHAWEQLNEHSAILTKRAVTGEAERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRM1</accession>
    <name>A0A8G1QRM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_431639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825085">
        <property type="protein sequence ID" value="RAH52344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510266.1">
        <property type="nucleotide sequence ID" value="XM_025658343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRM1"/>
    <dbReference type="GeneID" id="37161745"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="77"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="607" mass="66589" checksum="B4F8D75D38BBF5FD" modified="2022-01-19" version="1">MVFCGKPSKGCGECRSRKIRCDQARPTCSQCAKGNRVCPGYRDQLSLMFRDESQQVIRKARTGTKARRAKSSRKTDPGSTSTCSAPAAAAASPSGSGMVAASPSPAPVSSPASSNPSLSTGDLEPPEFDGPVCLSPQFVEQHAIQQPLVLQPSYQPTKNEAISYFLRQNAWIGSFWSKIEANPDILRRASATSHDALMTSLASVGIAMVSRIRKSEPMKIAAEKEYGNALQLLTTAVADQQQAKNNATLAAVLMLAIFEVITSRGSRFIDSWTNHIRGAVALLELRGVEQLQDPDGLQLFLQLRYQIIIGCLQREARVPDSVLHCVKVAMFLRPHTVAYGDRLINIMGRLANLRADIKEKILTDRKKMLESAYAIEAELMSWLTSLPGNFPYATIEDPWPTLKWGPKPYNNVYHVYTDFWICNSWNQYRVARIITSDLILTCIRELNAGSPLPADLVTHTSQIRNTARQLASDICASVPYYFTDSVFKLATGQAEMSSRYEIPSQQGFVRGLVLLWPLSMAAATRGLHHPLRHWALDCLQLIGHGMGIDQALALIELLMTEDGVFDTLALPEDNNLLIGSTGANFSTDNSGKHWTGASLSTYTAPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRW0</accession>
    <name>A0A8G1QRW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_454009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510410.1">
        <property type="nucleotide sequence ID" value="XM_025661179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRW0"/>
    <dbReference type="GeneID" id="37164581"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="54"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="528" mass="61474" checksum="D9302F90270F01B3" modified="2022-01-19" version="1">MKPRLHHDDVAWEKAEAITNAWVQQFFDPKILQSVAQFLSRHHGPGKIDEFSYLEKGSYNITFQMKNKNANSTVIRFVQPGSIMFPEEKVRNEVAMMRYINDQTAIPIPFVCHWGSREESPRGLGPFIIMEYVEHKTNMYDVLNRPGCPREERGVLNPDIREARLEALYGEVATVLLELSKTNFPRIGSLKQVDDFTWEVTKRPLSMSMNSLIRLGTLPRSKLPNTTFEATSSYFEALAELHIAHLINQRNDAIESADDCRRKLVARFLFRKLAREHHLTKPLDAFDNGPFKLWCDDFRPANILLSEELKIVGVFDWEFTYAAPVEFSFAPPWWLLIEKPEYWPQGLEDWCSKYQRRLPTFLKAIRDQEDRAIEQGWLDSTQRLSGHMRDSWESGDFWIAYAARNNFAFDLIYWHKIDQRFFGSTSIPIDDVWKQRLVILEPAERAEIEQIVAIKVEEMQTRPAWDPDGYTREVADTLCDNADNEPEREPSEYAPDERMYAGPTTLEELSLVGDGSFIVFNKLRSKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS96</accession>
    <name>A0A8G1QS96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_505968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510620.1">
        <property type="nucleotide sequence ID" value="XM_025664359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QS96"/>
    <dbReference type="GeneID" id="37167761"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="1">
        <location>
            <begin position="14"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="445" mass="50252" checksum="33F6AF0113198325" modified="2022-01-19" version="1">MNWLSAKSHAPIIKITIKDPKPSYTTWDRIEGTVTVTAPNDTNVNNIQITFEGSSRVALPRPITELREPTACHTFLKLQQPIETPNSPIHVPERTNSYPFCFVIPEELPLGSCMHEKSNGCVDYRHAKLPPTLRFANLSQELCRIAYSIRATVFYHIENDGNNERTTTSTRDLRFVPAHQSNHLPRSLQTFISLQHNPKQDVKSKASLSPCRLSVEGSSAQLTQGRCLGDSSNGSFDAYLTIPLRFEATGEAKAPRLRNLHCTLKASTFLATRPSVKRLKRHEAQYRQAHVETIAMRSEDISYTQWVRHEPAPGDCVTEHQSGDKLYYTTSIHLPIRMPRNGHLIPFSTCLLSRAYLLDMRMSYSTPDSNGRRRSLEATLPVNIAASYETYMEKIPLRNTLDELCLSDWGAEPPPYHGHELSRSSDVVSLRKGQHTGVYHHLVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSI4</accession>
    <name>A0A8G1QSI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_239696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825093">
        <property type="protein sequence ID" value="RAH51779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509701.1">
        <property type="nucleotide sequence ID" value="XM_025654828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSI4"/>
    <dbReference type="GeneID" id="37158230"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH51779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="95" mass="10292" checksum="71567A9FC10DDBA2" modified="2022-01-19" version="1">MRLSPPPRGGHFAEGPAAPHSVGCSSATFLGGGRRMVDYYHQTFFIMAFIFFSCLQNSDSDGEGPAQSYYQSASDQCKCKCQVPNLKLLSPPLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSY6</accession>
    <name>A0A8G1QSY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GPI anchored dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_211430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825089">
        <property type="protein sequence ID" value="RAH52019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509941.1">
        <property type="nucleotide sequence ID" value="XM_025654621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSY6"/>
    <dbReference type="GeneID" id="37158023"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF2">
        <property type="entry name" value="ANCHORED DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034002835" evidence="2">
        <location>
            <begin position="18"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="3">
        <location>
            <begin position="134"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH52019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="390" mass="42537" checksum="7B9684E8ADBA9451" modified="2022-01-19" version="1">MHFSKLLTLTAATLAFAHPGEKHDHEAVKREIRLRDALAEQARHGVNACSNSHQARQVQQRSVSRRANTARELRSKRGVTAAPHKFRRNLAALEKWEAINHNKTGLLDYSPQTSEADIFGANTSSILTPTITDGPYYVWGEVIRQNVKEDKYCDGVDLFLEVQYIDVNTCLPVQGALVDIWNANATGVYSGISTSGNYAADGWDSTFLRGIQETDEDGVVTFQTIFPGHYDGRAIHTHLLTHLNSTINRNNGTLQVGTGSVAHIGQLFWNEVLRTAVENTYPYTTNTQDITSNADDMWSVEQATSAYDPFPEFLYLGDSIEDGLFAWIQIGINTTADYTDNSYYSIAAYYDENGGHENSDSAAMGGGSGGGGAPSGSMSMSGAMPSSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT15</accession>
    <name>A0A8G1QT15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_453501</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511040.1">
        <property type="nucleotide sequence ID" value="XM_025661069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT15"/>
    <dbReference type="GeneID" id="37164471"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH53118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="466" mass="50970" checksum="1259E0A5E200D156" modified="2022-01-19" version="1">MSNAIRTLSPSTNKVIFEHPGLSLDEARQVAQASQDAFRTYKQTTLAQRKEIVLKALDLIAANKDTLAEELTTQMGRPIAFSAKEIETFRKRGDHILSIAEESLKSLPGTPENGFRRFLKKEPVGPTLIITAWNFPYLVTINALVPALLAGNTVLLRPSPQTPIFGERLLTYFTQAGLPPNVLQLVHVGSPDVLDQIVQLPQIQLISFTGSTSGGFRIREAVARRIVPVNLELGGNDPAYVRPDADIPYVAAQLVDGAVFNSGQSCCAVERVYVHADVHDKFVEEVQKELATYKLGSPHDKSTTTGPVVSKAALKNIQSHIDDALSKGAVNATPQNPTFENTPAEGNYQVPTVLTNVTHDMVVMREETFGPVMPIMKVSSDDEAVALMNDSDFGLTASVWTKDIAKGEELIERLDAGTVYINRCDYPSPDLAWIGWKNSGLGCTLGPEGFNAFYKLKSFHIKEQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT27</accession>
    <name>A0A8G1QT27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-ketoglutarate-dependent 2,4-dichlorophenoxyacetate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_523638</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511275.1">
        <property type="nucleotide sequence ID" value="XM_025665370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT27"/>
    <dbReference type="GeneID" id="37168772"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF3">
        <property type="entry name" value="(3R)-3-[(CARBOXYMETHYL)AMINO]FATTY ACID OXYGENASE_DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="10"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="256"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH53353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="352" mass="39422" checksum="A83AF8F7C71A462C" modified="2022-01-19" version="1">MTIGTPSLTFRRLHPTFGAECEGVDFSQPVPDAVIEELRAAMATYGVLVFRATKLDDARHFAFARQLGEPIVDNMVGAPGVPDRLGTRGKLMDVGNVDSKGQVLSPSSWRAQLLRGTRLFHVDGSFAQRRAGYSLLRAHKLPPKGTGGATAFADTRTAYADLAEETKAEIQNYVLWHSIMQSRCLGAPDNWFIRLVAAVSDLDDLRRIPYLMVVGLIARILGIWVDIVDISLLLIYCFVLVRIWVLCWLPAAVRARGRHQLAQLHKPSNRMNLYMGSHAYRIDGRSRADSKPVIDALMRHASQDKYVLTVDWQNDGDMIMWDNTCVMHRSCGGSYQGRYVRDMRRAAIYDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT29</accession>
    <name>A0A8G1QT29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_239018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825093">
        <property type="protein sequence ID" value="RAH51765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509687.1">
        <property type="nucleotide sequence ID" value="XM_025654819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT29"/>
    <dbReference type="GeneID" id="37158221"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH51765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="92" mass="9981" checksum="A20F80F9E64591DF" modified="2022-01-19" version="1">MTQGQLDQPPPIGPAGLSLVLFCESCFYINQMAYVTGFDLQSLSFIISSILTFSPTCVVVPPTLDGKSSKKGCSSHADFCARPYGEESERIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTL6</accession>
    <name>A0A8G1QTL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="2 8">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_429543</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="2 8"/>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511279.1">
        <property type="nucleotide sequence ID" value="XM_025658252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTL6"/>
    <dbReference type="GeneID" id="37161654"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF31">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="10">
        <location>
            <begin position="254"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH53357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="418" mass="45982" checksum="2B56B00B65288130" modified="2022-01-19" version="1">MPEHTRKHTVAVVGSGNWGSTISKIVAENTKEHPELFESKVRMWVFEEEIEVPESSRHHKRLGGQKRKLTEVINEVHENVKYLPDIALPDNVVADPDLKSAVKNATLLIFNLPHQFIGKTLDGVVGYHLPYARGISCIKGVDVSDGTVTLHSELIMERLGIYCGALSGANIAPEVAAEKFCETTIGYDTPPMDADERNGSPKDNLIKIDEQRQHKTKPTHVKLHPVPKDLPAVDAELWETLFARPYFHVNHVRDVAGVALGGALKNIVALASGFVAGKGWGENAKAAIMRVGILEMIKFGRTWFPKSVDERTFTEESAGLADVISSCSGGRNFRSACHAVEQGVSVNEIEQKELNGQKLQGTSTAYAVHDFLSKHDQLQEFPLFVAVHDILEGKSTVDDLPTLLDGKKKKKRRAPEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV00</accession>
    <name>A0A8G1QV00_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Citrinin biosynthesis transcriptional activator CtnR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_430304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511021.1">
        <property type="nucleotide sequence ID" value="XM_025658285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV00"/>
    <dbReference type="GeneID" id="37161687"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF3">
        <property type="entry name" value="C6 FINGER DOMAIN TRANSCRIPTION FACTOR DBAA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH53099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="553" mass="62210" checksum="C5FF9E6BF6B60B56" modified="2022-01-19" version="1">MSSPSPSSDQPQSRNRPGSACAECRRRKMRCDGKHPQCINCSNAGITCVFNPQPSRRGPKKGHLKTLQVRIANLENILFGQTQDPVSADTSTNGDVAAQPTVHGWNGEPQLNVLLNEFNAPAGAPSVGSVPVSNLLHAELDQLYFDRAHAFVPILNARRYLSWTRNTNKSVSRRCLQYAMWTITTSMSVQLEHLCEPLYQSVRQLLGYLQLVDGDSEVDQIEHIQALLILAVYEFTHQNFRRGWVSAGQGIRLVQLMDLHKLDLDKANNTGSHQASTLEDLVCAEEKRRVFWVAYILDRLISLRHESPLTFDERTIATRLPATEETFQTGQLSQMTGFLSKTIIEDRPLLKAELSEMVILASLCGKTVLHRQQAVAEQADNGISNSFWERHRWLDAVLIKKSRTISAVQPVTPTLPAEPVSLTPNLMIQSAILYHCMTLELLARATENSETLRQCRQRALLTVQEIIRLTEAVLQLSYFEISPFTPLPILLCAQVLMMYQETDASCMLQLQEVLGMVQNLANNNYLCREWVNQHSDLFDLEPDFVLAEAESHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV23</accession>
    <name>A0A8G1QV23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nitrilase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_432352</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825089">
        <property type="protein sequence ID" value="RAH51985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509907.1">
        <property type="nucleotide sequence ID" value="XM_025658378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV23"/>
    <dbReference type="GeneID" id="37161780"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000016">
        <property type="entry name" value="Nitrilase blr3397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF1">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00921">
        <property type="entry name" value="NITRIL_CHT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH51985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1030" mass="114554" checksum="E8370D82C9EBE420" modified="2022-01-19" version="1">MPQKLTVAVAQASTQCTLAATLAALERVTRHAAARGVHLILFPEAYLGGYPRTCDFGTAVGTRGAHGRDQFLEYFHAAVDLGDTPTGAGDDWVNRRLPLPRGKEYRGDGTREALEKISRETGVFIVCGVIERAGGSLYCSAIYVDPRDGALGKRRKVMPTASERLIWAQGSPSTLKAVTTELNGVRLTIGAAICWENYMPMLRQSLYSQNVNLYLAPTADARDTWLPLMRTVAGEGRTFVLSANQCVRRRELPGWITANSQDKHNGDEYICRGGSCIVGPLGEVLSEPIWEVSTDDVTDANDPNDPAMAAALSITEIDVEDCERGRLDLDVAGSYSRNDSFKLTVDGLDLNPPPCSQPRPCTNCVQAEAACVPSQRPARKSRVNPEYARVLEERIIELESQQRGTAHHALGLGTTSGLSKADMQPTESPEPPRTRMTRALTAEDATSPAFRLSSHIPGDAESTQAGSTPSVTILPPVVQGSPYPGFLPGTNYEMEIPSQTQDELIQTFLQRVNPRYPFLHEGTFIAWYESWKESRNLGVPLPPQEQWKAFFIKMALAVSLLIAPRVSPRDMKVSQALYSSATSSLDAVFACLDPVLHAQAYLLCTLHALHSPSSQTVLTMIAAAVRCCVVAQLHLSEVEHRPQELLWERQIRRRVFWSAYAIDRLVSWVYHVPCTLVDEDIQVEPFANMNDHEIKEWQVRADRLEPDASTPRRTQVSSALHLIRGRRIQSRILSIMMRADYDQRLAESHQWRLHMLEVLDEWKAQLEPHSDPLSKGYTSEGWVGMLYNYTVLLLYRPTKANMSDLVMEHCIRACTDIALTFWKYLKSRQTAQLWPGLLSQFGIGITLLYCLWVVPPSQQSIETQSPKIGPAIRTCSVILAVLSERWTEAEPLRDIFDLLADSIPVYWSHDGEARRISTSSAKTIQEYLPRVTAIVINKEIMRMLHEMATEEYPWAAGGTVNMGDWSSNDVHSAQDCPLCLGTRAHRADLPSVSFDATNLWPGFDNDTDHSLPALSGEYSLFPGLLGSIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV49</accession>
    <name>A0A8G1QV49_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_453262</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511096.1">
        <property type="nucleotide sequence ID" value="XM_025661016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV49"/>
    <dbReference type="GeneID" id="37164418"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH53174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="186" mass="20671" checksum="4BD8CF6CE2B51B5A" modified="2022-01-19" version="1">MVSLPPPPPPQWVVRMNTPMPRPSKEATSIPDPPGFSRKLTGKTNRAQQSSATSAPSKPVETDTLKLKKAWEIALAPSKQIPMNAIMMYMSGNSLQIFSIMMVFMLFKGPIQGLINTNTVFAKFDTEGTRAKLLGVKAIYVVMQLVLLCLGIWKVNAMGLLPTTRSDWLAWESERQPLERAYFAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV83</accession>
    <name>A0A8G1QV83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo-keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_452543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512104.1">
        <property type="nucleotide sequence ID" value="XM_025660844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV83"/>
    <dbReference type="GeneID" id="37164246"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000045">
        <property type="entry name" value="Aldo-keto reductase (AKR), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH54182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="317" mass="35578" checksum="EAABBF89CE227EF2" modified="2022-01-19" version="1">MARAAMTKLSWESHVLRPVQNAPPAIIPTLIYGTAWKKDQTADLVHQALGAGFRAVDTAAQPKHYREDLVGEGIRRALQDGYVRREDLHVQTKFTSVNGQSPDNMPYDPKASVTDQVHASIKSSLHNLRPSGTADSVNDAYIDMLILHSPLPTMSQTLEAWSAVESYVPHQIRSLGISNTTLSILKELFGQARVKPAVVQNRFYADTQYDVPLRAFCRENQIIYQSFWTLSANPDLIRSDAVQLLAHEADISPAAALYCLVLGLGHTTVLDGTTKRHHMEEDLAALQKIERFTEDQPDLWQRILKRFRQLTGDRMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVV1</accession>
    <name>A0A8G1QVV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_452252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512730.1">
        <property type="nucleotide sequence ID" value="XM_025660775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVV1"/>
    <dbReference type="GeneID" id="37164177"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="205" mass="21936" checksum="693635125BA39F7A" modified="2022-01-19" version="1">MSHFNNPDSVATNKQGEFHPSVKPTGPMEQGGHQVGRKVAPSDFVPEFRAESHPPGTAPASSSYQPNPTGEVGGQALNLNVERSHGKESVKTNASDTLMGATSQDVHRGMGQPISGQTSNELRHDGQHGRKGQSAGLEQVGASRGTTFERSMPSQRGLERDEARPGQRGDKGALAAEDRVPESAETAAAEWKYEPSTKRDNPHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVY4</accession>
    <name>A0A8G1QVY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ketose-bisphosphate aldolase class-II family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_384218</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the four-carbon acid sugar kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825085">
        <property type="protein sequence ID" value="RAH52390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510312.1">
        <property type="nucleotide sequence ID" value="XM_025656544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVY4"/>
    <dbReference type="GeneID" id="37159946"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.20">
        <property type="entry name" value="Four-carbon acid sugar kinase, nucleotide binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10840">
        <property type="entry name" value="Putative sugar-binding, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010737">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037051">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031475">
        <property type="entry name" value="NBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042213">
        <property type="entry name" value="NBD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17042">
        <property type="entry name" value="NBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07005">
        <property type="entry name" value="SBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142764">
        <property type="entry name" value="YgbK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Four-carbon acid sugar kinase N-terminal" evidence="8">
        <location>
            <begin position="43"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Four-carbon acid sugar kinase nucleotide binding" evidence="9">
        <location>
            <begin position="309"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH52390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="495" mass="52563" checksum="DDFA4BF6C432A9BC" modified="2022-01-19" version="1">MATPREYPVVPRESTLSQLPPESSLNAQDQISELLSTASLSRLVVLDDDPTGTQTCHDIAVLTVWDIPTLQAELQQPSPGFFILTNSRALPPIDAEKLIRTICENVQQAANLAGTTVDIVLRGDSTLRGHFPLEADVAQSVFGPADAIILAPFFFQGGRLTINDIHYVAEGDNLVPAGATQFARDATFGFKSSNLHDYVLEKAPGRFTPEQIHSITIEDIRINGPSTICDKLLALPKGSVVIVNAAAESDMHVFVAGLLKAKSQSQKHYLYRTAAAFVSTTLGIRPQPPLTASSFPSETQPNSKTGGTLIIAGSYVPKTTAQLNHLTTKHGPGGTNTLSIIELNVEDIITSSSSSTTEDPTSLDPIITSTVTAVESSLLAGKDVLVMTSRKLITGGDELSSLAIGGRVAEALVEVLKRVKVRPRVIIAKGGITSSDAATKGLGIKRAMILGQAAPGVPLWRCDEETATHRGVPFVVFPGNVGGVETLGEIVEGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QW83</accession>
    <name>A0A8G1QW83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_405853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511247.1">
        <property type="nucleotide sequence ID" value="XM_025657315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QW83"/>
    <dbReference type="GeneID" id="37160717"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF812">
        <property type="entry name" value="VPS9 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH53325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="329" mass="36211" checksum="0C3D0FC505D26428" modified="2022-01-19" version="1">MAPTVLITGATGFIGSRVALEALQAGYRARLSIRRPEQAEKLRRIFSRHLSNIDFVVVSDITVTGCFDEAIQDVQYVIHVASPLPDRNSDLLIPAMQGTTSILESACKISSIKKVVVTSSISSFMPLAGQPHGTVITEDTGVPYDAKQGISPLLDPMVQYRASKVASYQAIIDFVQQRNPPFDVTTFHPSWVYGRNPVQEPHDDPSGSCGALVLTLLSSAKPINGQFLGVHVDDVAAAHVKALGDSTRGFQSFLLSAPRQSWKEVNEFVRQQYPSVAWKLIPEDWMNYAVDSSRAEKELGLKFKPMEDQVRDTVDQQLEFGKLPVQSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXG2</accession>
    <name>A0A8G1QXG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_522798</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512311.1">
        <property type="nucleotide sequence ID" value="XM_025665293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXG2"/>
    <dbReference type="GeneID" id="37168695"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF7">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH54389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="577" mass="62495" checksum="9EEBD24A1E5B9089" modified="2022-01-19" version="1">MRQYSRAAAATVALAASARAASSSLASLCTVSHVQSILPANGTLLGIDMIPSSVTANTTTSDSTEYCAVSVSYVHTGTTNEIVLNYGFPSPADFKNRFYVAGGFGYSLSTSSTGGLEYGAVSGATSGGYGALDGTTVDEVNLSGNGTINWDPIFMFAYQALGEMTTIGKPLTRSFYGLDDDAKVYTYYEGCSDGGRQGMSQIQRYGDQYDGAIIGAPAFRYGQQQVNHLFSSVVEQTLDYYPPTCELEKIVNATIAACDPLDGRTDGVISRSDLCQLEFNLTSIIGEPYHCAAEVSTSLGFNFNKRSDGTSTSYTPAQNGNVTAKGVAVAQAIYDGLFNSAGERAYLSYRIGSEFSDGETSYDNSTGTWGVDIPSTGGEFVTRFIELVELSNLDSLANVTYDTLVEWMNVAMIRYMDTLQTTLPDLTNFKATGGKLIHYHGENDPSVPTASSVHYWQSVMSIMYPSLGSSKAIEQMKEWYQLYLVPGAAHCGRNTLQPNGPFPEDNMETMIQWVEQGIQPTGLNATVDAGKYDGEVQSLCQFPKRPVWKSNKWECESDDEGADTFYYTFPAFKVPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXI6</accession>
    <name>A0A8G1QXI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS8m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_451227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513365.1">
        <property type="nucleotide sequence ID" value="XM_025660542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXI6"/>
    <dbReference type="GeneID" id="37163944"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000006">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000005">
        <property type="entry name" value="Mitochondrial 40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH55443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="170" mass="18601" checksum="88F59012BABBF4D8" modified="2022-01-19" version="1">MSLVNLAHVCSHLNNACKARLGLTSIPNSKLHLKLALALQNDGYLSSVVRGGPTPPPVHPILGNPNPIDEVEGIEPVTQSNVATRRLWLGLKYWQSEPVLGKLSMVSKPTRRVTIDVAGLRRVIRGERDNTVEGIRSPGESLYISTDRGILEARECVEKKLGGLVLCRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXU1</accession>
    <name>A0A8G1QXU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Solute carrier family 40 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_480540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512057.1">
        <property type="nucleotide sequence ID" value="XM_025663015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXU1"/>
    <dbReference type="GeneID" id="37166417"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034722274" description="Solute carrier family 40 protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH54135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37568" checksum="87A55CE51DD0F001" modified="2022-01-19" version="1">MMVYVPSPHFLLSLFRILLNTFIPSAGGHPLLAQAHAIWRNEPTHSNNIFMSGLVRYIVGHVLVSILILESVEKQALGSFSDLRDKKAGPSSRQLFQTIATLYRTGNLRLLLNGIGSACSYWAKHLCTKQMLTRAIFLPRPVAYVVASVLLAEDRFLWNARTILPRDQQRFVPNSRDRQRWKALVPATALHAVAESFMMHFPALFKSDLASSASTDVTKAHLSGIVGFEILVSGVMLAAQFLLLFPSFIALVLVQTSLLPSVCETLVSTPVNPGGRQQQRGRRVGEIFAAFNRVSLRVQEVVKIIGATYVLWCVELHAKMCLCLIGVSAVVQVAIYDMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXZ8</accession>
    <name>A0A8G1QXZ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_80100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513605.1">
        <property type="nucleotide sequence ID" value="XM_025665674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXZ8"/>
    <dbReference type="GeneID" id="37169076"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="673"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="673"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH55683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="810" mass="88720" checksum="5FD77CBFE61C1C7D" modified="2022-01-19" version="1" fragment="single">MGLRRSCVFCRTRKIRCSGESICSACRKRNLSCEYSPEARKGRPAQRGTTTSQPPLASQPHDKNGSDNLSLLSGTPAENFSASDSQTHGHGESATSSDLSIHVGDELERRFNAYFITKTDSGSNIFQTAIATYQRELDKSPRKTPIHSIQLPLSYDGLLSFMASEMVGILPLRFSHLGVQQLEAPNQNFYVSTLAADTTCTMFDPLESAVDPLVVLGKHLILQLVDVWFSAHPLSPLVSKTLLATAIQDDTVDKALLAVILVDACGIQSIVSGLQKCAPIDPQTLYSFAILQLKQRTVVLGHPSVLSTAQALFLVGWRELCLGHARRATCFTGYACRIIATLYTFWQAGDHRKCSRKLNGVDVGAVEQELAQNVYWICLATTTWGFMQSNQPFSLLTPETTPDFPCLDEGASAILRLDRASGNISTLQAQIQATQCLWPLSHITSTVAHIYTLYLNAPTVNKEKQAVPWQKQHLHELHQLFQPCFDRSVLASRMHRILLNAIELVKNEVTVASSRSFLLTAYHSIAIHMLFSGDKNDQKRPAISPSVIDPFCQSASALLTILQQRPSRLANLMPTKEFRSVDESSIMLYALDTCSRGFSYIYAQHEHSSIEERNVISHQQSQLAHLANQLHEACKGDVISRLGAAILPVKKRLKRAKQAFEQLGSSAIPQSALLSSQNAQTPSSNSSAANDPLMDPGLNIGQMADPSLAPDGSESLPLMAIDQTLSLSENPCEIYDPGFFLDGPVTGSLLGFPGLAKMNMQLQDYVSLESDLDQDALAFLSQGTSGISFDELNVQSADTNPSDPQHSDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYJ2</accession>
    <name>A0A8G1QYJ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_381022</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511602.1">
        <property type="nucleotide sequence ID" value="XM_025656403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYJ2"/>
    <dbReference type="GeneID" id="37159805"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000026">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH53680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="316" mass="36437" checksum="71F83657430472F8" modified="2022-01-19" version="1">MAEEDTVNLDALIERLVAVRGSRPGKLVEISEAEIEYLCRTAREIFLTQPILLELEAPIKVCGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSIECICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNVRLWKTFIDCFNCLPLVAIIEDKIFCMHGGLSPDLSSMEQIRRIMRPTDIPDEGLLCDLLWADPGKHILGWGANERGVSFTFGPDVVHRFIQRHDLDLICRAHECVQDGYEFFAKRQLITLFSAPNYCGEFDNSGAMLDIDEELMCSFKILKPAEKRKQIFGKRSGKEKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZL7</accession>
    <name>A0A8G1QZL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase 213 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_521738</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513828.1">
        <property type="nucleotide sequence ID" value="XM_025665216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZL7"/>
    <dbReference type="GeneID" id="37168618"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039205">
        <property type="entry name" value="NDUFA11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH55906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="195" mass="20966" checksum="82CD090C9B1C4297" modified="2022-01-19" version="1">MAPHHEEHYHPKDAIAASMKTTMLTGGAGLFASAVQNTLTRQNVGPLGVFIRSGGTVGIFAAMGGTYEFVKTASANLREKEDHWNVALGGFFSGAILGLRARTFPALLGYGVALATATGAFEYTGGSLFGYKKNTDIDEFERREQLRKTYRIPAEQTLAELGEGRGIYGPGYAERRAERIKEAYGIEVPTTAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZW5</accession>
    <name>A0A8G1QZW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxisomal biogenesis factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_372177</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515413.1">
        <property type="nucleotide sequence ID" value="XM_025656028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZW5"/>
    <dbReference type="GeneID" id="37159430"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF50">
        <property type="entry name" value="PEROXIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH57491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="235" mass="26190" checksum="FA44700CCFE3EFB0" modified="2022-01-19" version="1">MVADALVYHPALAHYLRFVATTVGRDKLLRTLQYFSRFYAWYLYRTNRPQSAIEPFNAVKKQFGTTRKILRIGKFVEHLKAAALASDNKNPVDPVLRYLAVGRQLGYAGYLSLDTITVIDTIGVRKLASAKRLQEHAYRSWMAGLVCSAVAGVYTLFRLREKEKTLDRKEGQGVVEAKKLEKERSAARIQLISDLCDLSVPVSALGLASLDDGIVGLAGTVSSLIGIWSQWRKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1E0</accession>
    <name>A0A8G1R1E0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_270778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516193.1">
        <property type="nucleotide sequence ID" value="XM_025655083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1E0"/>
    <dbReference type="GeneID" id="37158485"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="80" mass="8837" checksum="296E5FC70A8AF185" modified="2022-01-19" version="1">MPSRASGKDRGTHMVPEGEDINPDQRGHPITGFPANSCCILYVPFLSHSPPLSPSPLPSFKFSTSIRYRATSWVYPSTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R213</accession>
    <name>A0A8G1R213_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair protein Pso2/Snm1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_487564</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515659.1">
        <property type="nucleotide sequence ID" value="XM_025663466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R213"/>
    <dbReference type="GeneID" id="37166868"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12650:FF:000007">
        <property type="entry name" value="DNA cross-link repair 1A protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000038">
        <property type="entry name" value="DNA cross-link repair protein pso2/snm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="676"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH57737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="835" mass="91304" checksum="EC33BE2B54916196" modified="2022-01-19" version="1">MPTPFPPRKTSTPSRSTPAKSKATKRNTSLLSFFQKADGPPKATSRQSRITQFATKAEKKDATGDAGSSGVRGGNGAAGAGGLFLEDAKKVVSFTNGGDYVREKTPEDIWEEEEERFQENGGSVKKRRVEEGISLEDDIDNGSGEDKKKTESESGTESKSTQKPSRSVSGPFIDESDSESEDLEQFREYENGTEIEAGVSDGKSNSADETQAPAVDVDTPPVREATSHDDDVYANFDDLEEDEFRGEEDFLDAFDDDEDFKGDIGLDDSGISGEDFGCEAPVCPVCQAVLTGLSETDVSVHVNDCLDGKPTESLKHEPEAEPDPDPEPGPELKSKGMSLADRAAIARPAQRDPYASGVAGTRSAFSKLMAGNAEDTAWNAAAANEVASRGKQAYQRTCPFYKIIPGFSLCVDAFRYGAVEGCNAYFLSHFHSDHYIGLTGSWRHGPIYCSRPTANLVCQQLKVDRKWLVPLEFEQKTEIPGTGGAQVTLIEANHCPGSAIFLFEKSMGSGPSQRTHRVLHCGDFRASPLHVQHALLRPEITDPATGKARQQRIDACYLDTTYLSPKYAFPGQEDVIEACADLCVELDQDANDTNGRAFGRPVNGKSGMLSKFVTAVTGSRPSPTQGSRPPGRLLVVIGTYSIGKERICLGIARALKSKIYATPAKQRVCACLEDAELSSLLTDDPTEAQVHMQTLFEIRAETLADYLDSMKPHFTRVVGFRPTGWTYRPPAGRMLDNPPVSVVLNSAHWKTPFSAKDLVPQRGSTRESACFGVPYSEHSSFRELSMFCCALRIGRVIPTVNVGSRKSRERMKAWIERWEAEKRKNGLYRVEGSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2J2</accession>
    <name>A0A8G1R2J2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fungal-specific transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_372511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515403.1">
        <property type="nucleotide sequence ID" value="XM_025656040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2J2"/>
    <dbReference type="GeneID" id="37159442"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH57481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="61837" checksum="9DF771399DCB69A5" modified="2022-01-19" version="1">MQLSWKPGYSLSNRPVKRSAARRTNRGRLGNADGPQQFVFVAEHPMRDLNISEEASLSVETPFKVSGDASPTTRAADSPGPETDSRTAELQPHRDNSEENQGQSLCSSTPTDDGQLQLADGDAFYEWSSQVATTIESSPMTASDFPNTTTSMPPSVLYNSIWQRFGPVLQRYNMEFCTIPLTFDLQMNPFRYRKTIVPEPMFLVHAVMALAGHHVKSPSTDDHRYTALKLLRESLNASGNVEDGSSVLDAIMILFSFDETQSTLGYWNTHLKGAYGLIEACGGIEAWTTSARADAQIGLLLWWDAITSLLSREDCVFPYAYVEAILSNPDDRKWNFFDLCGCPHSVVTLLMQVVRLSAEKRQSSSMRYVTFDTTMIAQIEQALESWHHISPAALAFDSSEEDIQKDQDCMHCSEAWRHGLLLYIYRVFRWKPGSPIPTHVVRWARVVVDHVVACRDESMVARQALLPLFFAGCELRDRSIRKKIVQFCSVWNDRTRYQMFGSTIPLLEEIWAEQEAKGFENVWWGHIVDRKHTVSCYPLQMRLCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2L0</accession>
    <name>A0A8G1R2L0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_458547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516191.1">
        <property type="nucleotide sequence ID" value="XM_025661595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2L0"/>
    <dbReference type="GeneID" id="37164997"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06591">
        <property type="entry name" value="GH31_xylosidase_XylS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051816">
        <property type="entry name" value="Glycosyl_Hydrolase_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863:SF2">
        <property type="entry name" value="MALTASE-GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="4">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="3">
        <location>
            <begin position="234"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="5">
        <location>
            <begin position="573"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH58269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="657" mass="75461" checksum="141D3F25B7039BA3" modified="2022-01-19" version="1">MLYTEDNKLIFRFDDHLLWIQPWGDNALRVRATKLASMPSEDWALSSEIPSTEPKPTISIEEHKDSSITNGKITAKVSQRGKITIYNHKGDKLLEEYARNRRDLKDPKCSALEVEARELRPILGGDFHLTMRFESLDPKEKIYGMGQYQQPFLNLKGADIELAHRNSQASVPFALSSLGYGFLWNNPAIGRAVLGTNTMSFEAYSTKVLDYWVVAGDSPAEIEEAYSKVTGYVPMMPEYGLGFWQCKLRYWNQEQLLDVAREYKRRNIPLDLIVVDFFHWKHQGEWSFDPEFWPDPDAMIKELQSLNVELMVSVWPTVENASTNYPEMLEKGLLIRHDRGLRVSMQCNGDITHFDATNPAARAYVWSKAKQNYYDKGIKVFWLDEAEPEYSVYDFDLYRYHAGSNLQIGNIFPKEYARGFYEGMESAGQTNIVNLLRCAWAGSQKYGALVWSGDIASSWSSFRNQLAAGLNMGLAGIPWWTTDIGGFHGGDPSDPAFRELFTRWFQWGAFCPVMRLHGDREPKPENRPTDSGSDNEIWSYGEEVYEICKKYIGIREELRDYTRGLMKEAHEKGTPVMRTLFYEFPADKRAWEVETEYLFGSKYLVVPVFEAGRRSIEVYLPAGASWKVWGQDDVIHEGGKVVQVECPIETMPVFVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2R6</accession>
    <name>A0A8G1R2R6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_469407</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514637.1">
        <property type="nucleotide sequence ID" value="XM_025662331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2R6"/>
    <dbReference type="GeneID" id="37165733"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="11"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH56715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="510" mass="55844" checksum="BBE3E0C2F74DDD9E" modified="2022-01-19" version="1">MSVTLRSGLYYALPPSIAGFAYGWEIASMSDILTMPQFLSYFDTPSAYRQGAMTAALQAGEFGGSLLIGFFLADQFGRRYTLLICVAIYLIGQAVVVAAQNQAMFIAGRVVNGLGAGGLFQSISLYTAETTPHTCRVAIGLLVSYWVQYGALKISGTAAWRMCFAFQLVPGVLVGILIYVRPESPRWLFQHDRGDEALQVLADLHGHGDCSNPSVQAEFQEIRVVVQYEGRAPPPSYLSLLIKAPYRRRTALAMGLQFMQNISGVNIVFYYAAKVFAQTGRTGTQAAMLANGIGSSIYLVASFSLTVMIDRYGRRKPLIIGPSLMGICMVIVGMLLVGYGSPHFDAGSQQLKYSFANVNAGNAAVAFVSLYMISFGSTCAVLPWTYQNEVFPISARGRGTALSACINWFANFWLGLYMPEALNKAAWKIYFVFGGICIATSFVTYLFYPETAQRSLEELDLLFTPNRRKLVCFDWEACQKGSLLHRGFEGVEVAQQLETALVMGGIQKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2Y3</accession>
    <name>A0A8G1R2Y3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeobox and C2H2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_394517</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025656924.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="37160326"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="147"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="370"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="149"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH59066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="658" mass="74573" checksum="BA4D7AB3B8E115C6" modified="2022-01-19" version="1">MVNSDHHEPPFSYCSHSREEDVAPTYLDSGEVSPMMHDLYPGVLSFDPSSLRYPVEERFDGNQHIPHSHNVTENYDFFGQLSLDSSIMENDPLHDFVRADCISHESLYESSCPEALSMASRDTGAFIGESAVDAPSALASDAEYEQGGRKRKSHYFPRETVRILRDWLDQRQKHPLATKEEREELLQRTGLTRTQLRNWLANSRRRGKARSSTMQQNESLPSGAVDIPHQSVSQMTPFERWRYSPPEHEPAAPSDIAQALSNLPPGSHAEQTTGSVNSTAHSLDSRTSQDSHPGNWDIFPTPSVGSHQTSRSSSSSISIASAFSQRSLPRSSLPGQSNYRRHRRRRQQRSKAPALANHLAPPHAQGLRRFQCTFCTDTFKTKYDWQRHEKSLHLSLEEWTCSPFGVIVSLDGHNVCALCLAINPDQKHLDLHNYHLCHEKGRQERTFSRKDHLHQHLRLVHNVKFGSWMESWKTSISEIQSRCGFCDTNLNTWTERVEHLATHFRAGMDMRQWQGDWGFETAVQGLVENAMPPYLIGQERLTTNPYSAKSAKALETSFEADSPAATGEDLVEDVNHWRILERELTDYIRSQLEIGVIPPDSTLQDMARMIVYSCDDPWNQTCADNPVWLGNLKRGAGVEDFRSRQSIMKTTGESGSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2Z6</accession>
    <name>A0A8G1R2Z6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_308417</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025655407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2Z6"/>
    <dbReference type="GeneID" id="37158809"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="41"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH57706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="607" mass="66267" checksum="B1064C7A9D017F4F" modified="2022-01-19" version="1">MAAAVRQLRVPEDPDQAPASSSDPVVVIVPTQTSPSYPQRVIGRKSPISGIEEFRGIPYGTVPARWQHALLRDRLPRDEFDATRNGPRCPQPQEPNNTDEFQSHLEFPADVTESEFDCLNLFITRSSAAILAAAGFSAQGVKLPVYVYIHGGAYSFGAGTDPMWDPARLVKKSVELGTPIIVATINYRLNMFGFAASSEIIQAQPEGQRKGCNFGLSDQRTAIRWVRQNIGAFGGDATQVTVGGQSAGGSSSHAHVLEAILGKGKPLVQRGIIQSGTLGVLGPISMDVSNARWNAFCQHAGAPAGDAISRMAFMANLPPAEILQAAGKLGSIVCPLVEDGLTISERPNGRWKVHLDGPESESVTKIPASKTEVIPILIGDTDVEGLLHMNEVNKIRDYEHLSEQLYAGVESREFLEQLYQAYGFRPDTSATELRKRVLQLLTDIQFGYPVQCARQELKDWEVPMEKLTESPTVPRPTAVHSYRMSVGNPFPGPRQGIAQHCVDLIYIFNCFADAISVADEALPAEAPTNAALVDRVQEDWIRFITAPSPDIETGNATVYGSDRTASTVHMDSDQTWTDRLHRFQVLGRHWRSAQQAIQAITGPSQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3H2</accession>
    <name>A0A8G1R3H2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_395536</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516394.1">
        <property type="nucleotide sequence ID" value="XM_025656965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3H2"/>
    <dbReference type="GeneID" id="37160367"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000024">
        <property type="entry name" value="Sulfate permease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
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        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="559"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="718"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="809" mass="88242" checksum="6F74B18895F7C01B" modified="2022-01-19" version="1">MTTKVGHLLAKVLGIDLASNTDPYLRDGSDTAGHYVETEPTAGEWLRELVPSRRQIGRYFYDLFPFLHWIMSYNLQWFIGDLIAGVTVGAVVIPQGMAYAILAKLPAEYGLYSSFMGVLIYWFFATSKDITIGPVAVMSTLVGTIIIEVQKDYPDVDGPTIAGALAIICGAIVTFIGLFRLGFIVDFIPLPAITAFMTGSAINVCAGQVKTVLGETADFSTRGSTYMVIINTLKYLPTSQMDAAMGLTALAMLYAIRAACNYGTRKYPRKAKLFFFLNTLRTVFVILFYTMISAAVNLHRRNNPAFKMLGKVPYGFQHAGVPKINVDIIKTFAKELPAAVIVLVIEHIAISKSFGRVNNYTINPSQEFIAIGISNLLGPFLGGYPATGSFSRTAIKAKSGVRTPLAGVITAIVVLLAIYALPALFFFIPSSSLSAVIIHAVGDLITPPKVIYQFWRVSPLDALIALIGIIVIIFSSIEDGIYCTICISVAVLLFRIAKARGQFLGQVQIHSVIGDHLVEETGSAKEFNSAAQLSSSDYKHTSSRTVFLPLKHSDGSNPTIPITQPAPGIFIYRVSEGFNYPNANHYTDNLVEHIFESTRRTNPSLYATPGDRPWNDPAPRKSKAEQIANSTEKPLLRAVILDFSAVNNVDVTSVQNLIDVRSQLDRYAAPDRVQWHFAHINNRWTKRALAAAGFGRPLDVPELKPIFNITEAVYSGDSSDQRASDIESQAGDQLKQSKSRDDKNAGVLSIREMDEAAKGSERTAVQRRGDGKPAVVTGVNLPLFHIDLKSALECVMASVSDTPGKVHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3J1</accession>
    <name>A0A8G1R3J1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LaeA-like methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_477175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="A0A8G1R3J1"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008168">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
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    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF50">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="282" mass="32202" checksum="BF76DA6B88A65A9D" modified="2022-01-19" version="1">MAAQDKYCFERDKKESERLDAQHHVLVRTSGNTLIHPSIPVEDIRSVADIATGTGIWLRDLKKSLDTPQVDRYYHGFDISSEQFPENPGTIQFSVQDLTVPFPQEHWGRYDLVHVRLLVAALEEPDYKAAIANISKILKRGGYLQWEEIDAETYLTKGYPVLSELYRCFDYGLTAEGKCFRASAKIYEETRAAGFVGVERLCYGSHKISDLRYDVEERLTAIIRTLYAFLLLRSKQVDTAEVASQEAEKLAEKHRRQCAEGNSPPLKLMRVVGQKPLYRPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3N7</accession>
    <name>A0A8G1R3N7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_518787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516791.1">
        <property type="nucleotide sequence ID" value="XM_025664996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3N7"/>
    <dbReference type="GeneID" id="37168398"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034222340" evidence="2">
        <location>
            <begin position="22"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="156" mass="16532" checksum="FAC3682841139B7B" modified="2022-01-19" version="1">MQLFSALTFTVATTLLTSVHGTATIGQACSGSSTYDCTDDFNAVAICNGARWVEAAQCGGGCCAWPLGDPAPFSQSHTLSVFGLVAGKVRGHCLSISCGVISSVMYIRSMSDCVVVSDAMTYSVIMDELRTPDELENSEDTDLRPKKPSQFLLSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R446</accession>
    <name>A0A8G1R446_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">sn-1,2-diacylglycerol cholinephosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_450508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514407.1">
        <property type="nucleotide sequence ID" value="XM_025660389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R446"/>
    <dbReference type="GeneID" id="37163791"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000029">
        <property type="entry name" value="CDP-alcohol phosphatidyltransferase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF77">
        <property type="entry name" value="CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="428" mass="48421" checksum="891FA114529D6700" modified="2022-01-19" version="1">MSVIFKKIQAIQDSLSDDVLLPLKSYKYSSVDKSYISNYILRHYWNAFVEILPLWLAPNMVTLLGFLFIVGNVMLIEVYMPDLVGPAPSWLYYSFALGMWMYSTLDNVDGKQARRTGTSSGLGELFDHGIDSLNCTLASLLETAAMGYGSSQLGAYTALVPCLAMYFSTWETYHTHTLYLGYFNGPTEGLLIAIAIMIASGIYGPQIWSRPIVQFLNYPQIFGNNSMKDLWVPILLLSFFLGHLPGCVLNVIAARRKQNLPVAPIFKEWVPMIVFTGCNIAWLFSPYSTLLSENRLVLYCWTISFVFGRITTKIILAHLLRQPFPHWTVLQIPLIGGAILANLPRLGFPMVSAWVELLYLRLYLVFAFVVYMHWAFLVINRITTFLGINCLTIRRDKSAARDRAYREFGENQPLNPNSDPSKGGIKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4M2</accession>
    <name>A0A8G1R4M2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_518302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517395.1">
        <property type="nucleotide sequence ID" value="XM_025664962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4M2"/>
    <dbReference type="GeneID" id="37168364"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF161">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="218"/>
        </location>
    </feature>
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        <location>
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            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="58"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH59473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="372" mass="41527" checksum="AF9421BBD1FD2D20" modified="2022-01-19" version="1">MSSNLPGQVLTRHSSHDARGHDTGMAIQFYNIFVYPIVRDQLIANTVLVALSTASIGLRFMSRKIRQSKFWWDDAFIVISMLHTYGMLAMQYHYARVGMRHHVTELPAVNTILIFKMLIVYQIVYYNAMVTAKFSYLFFYLRIFVTPGFRMAARVCMGCAGAYWLGSMLQVFLICQPFAKNWNAALPGHCASMNVAFSTIGAFNLVTDLLIMALPVHHIWKLQMSTGTKVALYGIFGVGLFISAITIIRIHVLTTVDFTDLSYSMIWAAFWSVTEPALAITNACVPMMRPVFKAAFPGIFSSAKNAYSSQTGAQSGASGSAFKRMRDTESEMPLTHLVPTKSGSRGVEYEASLNDRSQDEHVPRSVIGESER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4M9</accession>
    <name>A0A8G1R4M9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS drug efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_418425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517115.1">
        <property type="nucleotide sequence ID" value="XM_025657815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4M9"/>
    <dbReference type="GeneID" id="37161217"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000784">
        <property type="entry name" value="MFS drug efflux pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="54"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH59193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="578" mass="62285" checksum="372BBD27C5D8AFB5" modified="2022-01-19" version="1">MELTDHSSQSQTDEKAVAESPPTGNMERKFSHDEVVAYEEMGAPVDNPMTFRRFMGFTAMAFLWTGSQIPVYLFGGIPPYVYGDIGGADRWVWFVLANLLALAGVCPFVGSLSDLIGRRYVALIGASLVCLGMVVSSTAHTMNIFIAGMAIAGAGAGINELTALAATSEMAPTRQRGKYVSVLIFTILPFCPSVLWAQLIAAHSGWRYVGAFCGAWSGFGLLITALFYFPPPRVNSEGLTRSDIISRIDYIGGFLSISGLIIFLAGLQWGGYMYDWTSAHVLVPLILGFVVLVVFAFWEIYGAKYPIFPSRLKQEPRILGLTLVITFISGANFFSVLMFWPTQSFNVYGHDPVDVGIRSLPIGLGIMAGACIILWLLSVLHGHNKELLIISSVLMTAGCGAMSIGRPDNLYQLWGILIIAGLGIGGIIVPASIITTIICPDDLIATISALTLSIRVAGGGIGYTIYYNIFISKFVPNAQHYIGGVMLTELNITNTTYIAEAIELTGASLLDELKLIPGIAGNETAYNAVVAAGQLAYAESYKWVYYASIGFGGVSIIAACFLGNIKKYMNDHVAVVMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4W4</accession>
    <name>A0A8G1R4W4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="5">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_280755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516648.1">
        <property type="nucleotide sequence ID" value="XM_025655196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4W4"/>
    <dbReference type="GeneID" id="37158598"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000008">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="8">
        <location>
            <begin position="221"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH58726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="318" mass="35214" checksum="77F9AE6D54EC4680" modified="2022-01-19" version="1">MDIEPTLPIPISYIGGSYFLFSIDAVTYVRREHHICGVLSGTLPQIPQQNVFLGLPLKLMPEEARLLVEKGVACIVDEVKVQKDGMRALMEEDRKKYLRELESQGQHAMRLQHDRKEQQREKALKKIEEKKAAKAKKFAEKQQQEEQPDPVNNEAAAAKDPVVDLFAHDQQSSRRSSSATAAAAAPFGTAMGVTPATSYPPLPYEWSAEQRLPLPDVPASYPLFAHLHSEGYYLSPGLRFGCQYLAYPGDPLRFHSHFLSVSAEWDEELDLMSIVAGGRLGTGVKKGFMIGGAEKKLEGSDAGDPSSVRTFSIEWGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5J5</accession>
    <name>A0A8G1R5J5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_278528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516556.1">
        <property type="nucleotide sequence ID" value="XM_025655167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5J5"/>
    <dbReference type="GeneID" id="37158569"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="151" mass="16829" checksum="E025C99AC0DB0E2A" modified="2022-01-19" version="1">MDYPRQFLWMCWMATQEGGRWEDDGTSVARAESDGKGKEKDGRKAGQPPPPRLARCDAKDVNEKGRCVEKGIQVYSMTPRPPLSNPDGIADWGGGETTRNTRKTMDGIKDVPMGNQTYLCRVAPEYRIRRDEKGRIAMVVEGVGRGVGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6N6</accession>
    <name>A0A8G1R6N6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Purine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_368159</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517409.1">
        <property type="nucleotide sequence ID" value="XM_025655853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6N6"/>
    <dbReference type="GeneID" id="37159255"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042907">
        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810:SF2">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH59487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="560" mass="59747" checksum="F4B341F01665AD78" modified="2022-01-19" version="1">MESKSSPISTEESPSHSTGEVLHASSKWGYWKHYLTSRDGWIGDYDYMYLITPNIYPLNKRYKGAEPPFYGLNDEVPILLTIILGLQHALTMIGSVVSPPLALASGAFYLNSVQSQYLVSAAFITTGIATALQVTRIHLFKTPLYIGTGLLSVVGPTFDVIAVAMNYADTRYNNGSCPTDENESRLPCPEAWGAVLGTCLCTVWIQILMSLVPPKVLNRIFPKVVTGSLLLLVGVYLISSGMENWGGSSNCDGGTGYYALCPNVDAPRPLPWGDPKLIGLGFSVFATIIFVEFVGSPLMKSASVILGLAVGCAISGATGYWSRDEIDAAPVGTFLWVHTFPLSVDGALVLPLLIMFVCEAVSCMPDILATAEISRVDIEGREFHSRIQGGILCDGLGSLISALGTGLPMVSQAGNNGVISLTGCASRRAGWCASAFLLLMGIFGKFGAVFGSMPPSVLGGMQVFLYSTIVVAGARVLGLVDFNRRNRFILTASLGIGMMDIVSPSWFSSVLAYSGPNVHLQGFEQGINLIVETPFIIAAVVGVVLNLVLKEDEKADTVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6Q3</accession>
    <name>A0A8G1R6Q3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_283418</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515697.1">
        <property type="nucleotide sequence ID" value="XM_025655220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6Q3"/>
    <dbReference type="GeneID" id="37158622"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH57775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="875" mass="97605" checksum="97CD3A0F083EFDAE" modified="2022-01-19" version="1">MAPAQPDHLKATKRSIMRVNPQRRPVPTRRHRKVLSCTSCRDRKVKCDRSKPCAQCVRANAQDACFYSSATSSPSQSSPGLTPRSAKRSLIVREEDAQTANAVRQLSAGPSLGTPPSTVTAGSTCNVDGDAAARRSIFRSSPLSAVGSTRGIKAPRCFDVQPQHDRGQASSASGDTFSQYLSPLSFRGKQQRTRFFGRSHWATTLGMFPDFNAHLHEYYRNKQTPTNPGFTDYLSLRRLKHDLRGPERRRQSDQPPSSKLIELLPDRPLAEYLMRSYFSTFETTLRILHVPAFISEWKAFCDRNVSHADGLLNSKSEIFIAKLLMLMACASCFATEKTEPLASAGFSPQSLIQTCHTWISAVTTWLAAMTSHAQLSLDVIQIKCLLLLAQQATARDGDLASLASGSLLREAMLTGLHRDPCNFPSISPFWAELRKRLWLTVIELELQASLYSGIPLAVSWDEFDSPLPSDIDDEDITIDSLHVPPSRQSNILTRTSFQIALAQTLETRIAISKMINRVRLSATYNDEVTTLSELLTTGLAQAPADLRDDPSASPSPNDSSVKTEFRRSFFLFLHYRSLLALHRPFFLRFTETQVGQEPFIFSRRVCVQTSLALLSQLERFPHHRPNNNQPSAPLPNNDNQFSPHIHHLKGGLFRDDLFHAAATICFELRLQTKSHDRVVDIPFPGSSSISKYMDQSVYYQRLALFESVENTIRYFEGKVRVEKRATKMFSILMILFMVVRSDMVAAKDGSIDGDGGGETVPLGVDDACPVASRRCRDVLLEGYQCQGEEREMGRRLGEGESGGVYQVQAESSQTQGLESDTAVDACHHTNAPRPVTWDDAAAGDLRHLDFDWCFALDPLSPYPINNWADLDPLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7J9</accession>
    <name>A0A8G1R7J9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphoketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_510684</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517636.1">
        <property type="nucleotide sequence ID" value="XM_025664561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7J9"/>
    <dbReference type="GeneID" id="37167963"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02011">
        <property type="entry name" value="TPP_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003617">
        <property type="entry name" value="PRK05261.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003619">
        <property type="entry name" value="PRK05261.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF0">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="6">
        <location>
            <begin position="25"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="5">
        <location>
            <begin position="604"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH59714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="815" mass="92095" checksum="4757389F6A87A9A6" modified="2022-01-19" version="1">MPSDSNDQSISAYGAARSTVKGQNLDPEEVRKMDAYFRASMYLCLGMLYLRDNVLLKQPLKVEHLKARLLGHWGSDAGQSFTWIHMNRLIKKYDLDVLFISGPGHGAPGILSQSYLEGVYSEVYPDKSEDERGMQRFFKQFSFPGGIGSHATPETPGSLHEGGELGYSISHAFGTVFDHPNLITLTMVGDGEAETGPLATSWHSTKYLNPCTDGAVLPVLHLNGYKINNPTLLARISHDELSALMKGYGWTPYFVEGSDRETMHQAMAATLEHCVLEIRKFQKKARESKEPFRPHWPMIILRSPKGWSAPREVDGKLLEGFWRAHQIPITDVLTNPSHLQLLESWMKSYRPEELFTREGRLISELKALAPTGNYRMSANPVGNGGLLRRPLDLPDFRKYALTSIDPGATIRGSMVNMSHYLRDVVAFNQTNFRVFGPDETESNKLSEIYKAGKKVWLAEYFPEDSNGGNLSMAGRVMEMLSEHTCEGWLEGYVLSGRHGLLNSYEPFIHIIDSMVNQHCKWIEKCLEVEWRAKVASLNILLTATVWRQDHNGFTHQDPGFLDVVANKSPEVVRIYLPPDGNSLLSVMDHCFRSANYVNVIVADKQDHIQFMDMDAAIAHCSKGVGIWDWASNDQGAEPDVVMAACGDVPTHEALAATALLREHLPQLKVRFVNVVDLFKLMSKIHHPHGMSDREWKAIFTADRPIVFNFHSYPWLIHRLTYKRPGQENIHVRGYKEKGNIDTPFELAVRNQTDRYSLAVDAIDHARGLGNTASGVRERFLNMQLLAKQKAYDDGIDPDYIRNWTWQYPRKKGEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7L6</accession>
    <name>A0A8G1R7L6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA replication regulator Sld3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_446160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518921.1">
        <property type="nucleotide sequence ID" value="XM_025659441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7L6"/>
    <dbReference type="GeneID" id="37162843"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2130:FF:000001">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013948">
        <property type="entry name" value="DNA_replication_reg_Sld3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042511">
        <property type="entry name" value="Sld3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08639">
        <property type="entry name" value="Sld3_STD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication regulator Sld3 C-terminal" evidence="2">
        <location>
            <begin position="300"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="982" mass="106455" checksum="D86B1B21C4A6ECD2" modified="2022-01-19" version="1">MATTTTTAATSPPTSNILAPIPLNLVPSHTTSSSLSTASIENNPFKKRKVSHSETVNVHNDVFAVSGSPQTISIRSHSASLAEDQDPYHHLTPITTLSRNAIPYSWIDFEPREPKSQSQNLPGWCNIFVGDIPVLENENAKDTVLAVRVVGEAGVWVVERVKKGVYALMRLRGVGEGEVVVAAKASAGSAFPFSFSSGTDRRRGRQEVREWWEVAKIEDPEPVVLGKRGRGAADVEVVFAHVFESDARETQDEMLRSDEGSEGPVLLGVGEQSGDAAAAAAAAATAAEEQDVEVTQSPQELLDGLREQYLQALYVSKTSVAYFAKGPLARCRAAFQSSDNESGKPAQLVEFYREAILTAKRMDHKYRETLPTTVQDLLLSVSDDEAAPPKRKRRSTKKKLGKNGLYPEESDLIRKWWRDRALNDQGLPSEMSRDAESKKHIADLRLRETQLQILLILETMALEAIIADEKKREGNGEGADKPTKTAKGKKPQDLNVMLELHLDRLCIWHAVSFEETVVPDSAKTNHLSGKKVESDAVRDFCTEVIVPFYASRLPDKCKLITRKLGVSTAISPFTKQSQTKKTPREPGTPVERQHAQKSRRRAFQRVLTDQAPSQTRQPPSLSRSNTTPAPTESRRESLDPLLPTVSANVRGGIQKAKRVENREVDLNAVARQHETKLKKMQMLVDQKKELDAAIHALRKPNRELVAKDIAEDASKRLSTGGGSSRKPKNPVRNPYGQGVQVAATPKGSRKKDVMADMPPLPKSLSQPALIPQGSSSSPFTSEPQIVPGSNIRPSNSGLFRSADDGAIQETPTRRPTQPLSSADISASPKRKISGPLFRVPSKPAPAPTSVPAPVPPAFRATEKGPTTPIAARHVDAYMPRVKSIGSSKPSMIMETPPKPAMAPAFSIASAPAATEPAAVAGTPVKATTTITTTPAKANVFATPVKGASAARLAVPTAAPTVPVTPEKSIYAQLGWDDDDDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7Y2</accession>
    <name>A0A8G1R7Y2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_220656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518069.1">
        <property type="nucleotide sequence ID" value="XM_025654689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7Y2"/>
    <dbReference type="GeneID" id="37158091"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH60147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="61" mass="6912" checksum="CCBAFE8E5F0915A8" modified="2022-01-19" version="1">MISTIPLPSDYRNAEKWRQYDPTSKWIIGKYGVSLGLLMTLRHFAANEIQNCRPATTAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R827</accession>
    <name>A0A8G1R827_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_486401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517876.1">
        <property type="nucleotide sequence ID" value="XM_025663389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R827"/>
    <dbReference type="GeneID" id="37166791"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="171" mass="17819" checksum="82669F620541C561" modified="2022-01-19" version="1">MVQGNGRNDGGSSSREYGMNFEVAPPTTVPLGVPVTLPVIVGVRPVGNPRGVQQLVAHASLRNEAGTAPASGLTGVLTSSVRSRNGNGTSGYARFGPLKFTQPGRYRMRVMLGAASFNGVTTKEYVESGIIQVQAGAATPRPTPTQVSKLQTLIPENIDITAADIATWQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R876</accession>
    <name>A0A8G1R876_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_256828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH60029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517951.1">
        <property type="nucleotide sequence ID" value="XM_025654990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R876"/>
    <dbReference type="GeneID" id="37158392"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254:SF1">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="97" mass="10747" checksum="F5126AF2561527F6" modified="2022-01-19" version="1">MVFSQTLRRAAAQSAGAYRSPFAPKYHTPLHFHGLTTGLATKYTSSATIAGTFGVAAGTFALFFFGEIPRVRRDILQKVPFLDEYFDRTIAPEDNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8D5</accession>
    <name>A0A8G1R8D5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GABA permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_417081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517622.1">
        <property type="nucleotide sequence ID" value="XM_025657758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8D5"/>
    <dbReference type="GeneID" id="37161160"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF4">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH59700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="533" mass="58748" checksum="F585B007E75995B2" modified="2022-01-19" version="1">MSSATGEAGSIQKGDRVVTTGCHPLEIEAGERSSGEAGTRYDHSDMNRMGKAQEFKRNLRPLAALSFASVLQATWEFILISNYEGLEDGGMAGLVWTYVWTFVGFGFIIVSLSEMASMAPTSGGQYHWVSEFASPRYQKFLSYITGWMSVLAWQAGAASGSFLTGTIIQGLISVRNPDYDPKRWQGTLFVFAMILIIYFFNVYAASWMPRIQNALLALHTICWVVVIVVLWAMAPRQSAKAVFTEFSLYGGWNNVGLALMIGQISAIYGSLSSDATAHMSEEVRDAGRYVPMAICGGYFSNGILALVLIITLMFAMPSVKDALDDPTGFPFIYVFKQAVSTAGVNGLTAIILIPVIFSNILFNASTARQTYAFARDRGLPFSKWISKVNQHYKLPVNAIALSCIISGLLSLINIGSDTAFNAIISLNVAALMWTYAISISCVMYRKIACPETLPPRRWSLGKHGIWINAVALVYVIFALFWSFWPTEIPVTLNNFNWSVVLFVGVFVISLAMYVVQGRRVYKGPVVDVKRESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8H9</accession>
    <name>A0A8G1R8H9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cprA</name>
        <name evidence="24" type="ORF">BO85DRAFT_435706</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20 21">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8H9"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000111">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
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    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
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    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="66"/>
            <end position="221"/>
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    </evidence>
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    <sequence length="695" mass="76541" checksum="87B77F2CEED1D9F3" modified="2022-01-19" version="1">MAQLDTLDLVVLAVLLVGSVAYFTKGTYWAVAKDPYASTGPAMNGAAKAGKTRNIIEKMEETGKNCVIFYGSQTGTAEDYASRLAKEGSQRFGLKTMVADLEEYDYENLDQFPEDKVAVFVLATYGEGEPTDNAVEFYQFFTGDDVAFESGASADEKPLSKLKYVAFGLGNNTYEHYNAMVRQVDAAFQKLGAQRIGSAGEGDDGAGTMEEDFLAWKEPMWAALSESMDLQEREAVYEPVFCVTENESLSPEDETVYLGEPTQSHLQGTPKGPYSAHNPFIAPIAESRELFTVKDRNCLHMEISIAGSNLSYQTGDHIAVWPTNAGAEVDRFLQVFGLEGKRDSVINIKGIDVTAKVPIPTPTTYDAAVRYYMEVCAPVSRQFVATLAAFAPDEESKAEIVRLGSDKDYFHEKVTNQCFNIAQALQSITSKPFSAVPFSLLIEGITKLQPRYYSISSSSLVQKDKISITAVVESVRLPGASHMVKGVTTNYLLALKQKQNGDPSPDPHGLTYSITGPRNKYDGIHVPVHVRHSNFKLPSDPSRPIIMVGPGTGVAPFRGFIQERAALAAKGEKVGPTVLFFGCRKSDEDFLYKDEWKTYQDQLGDNLKIITAFSREGPQKVYVQHRLREHSELVSDLLKQKATFYVCGDAANMAREVNLVLGQIIAAQRGLPAEKGEEMVKHMRSSGSYQEDVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8N9</accession>
    <name>A0A8G1R8N9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_364115</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
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        <property type="protein sequence ID" value="RAH61217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025655685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8N9"/>
    <dbReference type="GeneID" id="37159087"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF46">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="104"/>
            <end position="127"/>
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            <begin position="458"/>
            <end position="475"/>
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    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="712"/>
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        </location>
    </feature>
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            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
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            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
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            <begin position="753"/>
            <end position="767"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH61217.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="774" mass="88035" checksum="F9DA30FED28B1EBE" modified="2022-01-19" version="1">MAEEPSSKLLAAWPTRDIIYISILGPLLLAALLEWFLFLAAFIYCLIKVYQKADHWSIRVLAVIMALLITLCRGIFLPVMIAILPLPPQITQFFPRQLVSVLQWFAFWAFSALLIIPWLFCVNRFVIHSLGRTKRVKEALDDRTAPKTVIVMPVYKEDPLVLIKAIDSVVNSDYPSYCIHVFLSYDGCNIDEPYLHVINHLGIPISLESYPQSIDVTYHGARITVSRFKHGGKRHCQKQTFRLIDKVYADYLKHHDDLFLLFIDSDCILDKLCLQNFMYDMELKPGSQHNMLAMTGIITSTTERNSLITVLQDMEYIHGQLVERTVESGCGAVTCLPGALTILRFSAFRKMARYYFADKAEQCEDLFDYGKCHLGEDRWLTHLFMIGAIERYQIQMCTSAFCKTEAVQTFCSLLKQRRRWFLGYITNEVCMLTDVRLWKRYPLLCLVRFMQNTIRTTALLFFILVISLITTSSKIKNLPVGFIAVSLGLNYILMVYFGIRLKRFKAWLYPLMFILNPFFNWLYIVYGIFTAGQRTWGGPRADAARADEHTTPEEAVEKARVQGDELNVQVDTFRTKTEEKGVPIRPSSKVNGRLSFAPQLLDRYYDYQGALGTSLAKYLTPLPDVPRIGLHPHCSSDSVATSDSGGNSISLPQNVESLMSAGERARLSISRQAQEDTGLLHTRGADGGEHGLYVQSNEDPVENRAYELHTIESESNVPSGKPQVSSSVPQSVMQQSRAVPGSQPHGHLPQPRYTKRPSRIPRQKKGHMQPEQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8V4</accession>
    <name>A0A8G1R8V4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">6-phosphogluconate dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_466567</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519229.1">
        <property type="nucleotide sequence ID" value="XM_025662135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8V4"/>
    <dbReference type="GeneID" id="37165537"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="5">
        <location>
            <begin position="3"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="6">
        <location>
            <begin position="175"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="314" mass="33298" checksum="2C38E091E24933B2" modified="2022-01-19" version="1">MTQIGWFGLGSMGLAMASNLQRHLARKTGPGLIYSNRTISRGDPLKKLGGTPADNFSKLVSQCGIIFTMVSNDSVLQELVTTAINSGHSLKDKIFVDCSTVLPETVGTAVSKLKEKDAKFLSAPVFGGNPIAVDGKLVFAIGGPKQAAEVVKPFIQDVMGRKVIDCGEDAMKSSLLKIAGNIITVNLMEAVGEAQVFAEKTGLGTGPMEDLIGEAFGGVAGGYSKRLTTGAYAPPLDSRPGFGVSLAIKDAKHAFSMAKEHNVELPGLQVSLDNMEAAREYAGECLDSSSMYGYLRQKAGLEFWNEKSRQGNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9J4</accession>
    <name>A0A8G1R9J4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box and JmjC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_236718</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518626.1">
        <property type="nucleotide sequence ID" value="XM_025654807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9J4"/>
    <dbReference type="GeneID" id="37158209"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF21">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="65"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="3">
        <location>
            <begin position="266"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH60704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="509" mass="56957" checksum="146E16DAB3B001C4" modified="2022-01-19" version="1">MKMPDINSLDCARPLGGAVAAHSYSSHPEPDVEDLSGHEEIPGHPLGVKPSGNALLAAENLRHAIGTFNILPDESILMLLEYLDGPSLLNIGQTCKAFYAFTRAEDLWKALFTGSPPASFSWKGTWRSTYLNIPPSEECILDCSNLFSDVLHRPFHCAHISLDPYIKNIPARNQIARLPDLSFEEFNEKWSNTPFILTEPVKQWPAYKNWSVNMLLDHYGEAIFRAEAVDWPFHTYVDYMHNNSDESPLYLFDRAFVSKMGLKVGQPDQEPDATYWPPSCFGEDFFSVLGNDRPDRQWLIIGPERSGSTFHKDPNATSAWNAVVRGSKYWIMFPSSSKLPPPPGVYVSDDQSEVTSPLSIAEWLFGFHAEARRSPGCIEGICHEGEILHVPSGWWHLVVNIEPAIAITQNFIPRAHLSAALDFLSNKADQVSGFRKDVNNPYERFVAQMQKSHPELLEQAQAELQKKNEGKKRKWDEIVHGNAEQDGGDAAEGGGFSFGFGDDSDVEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9R5</accession>
    <name>A0A8G1R9R5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_129049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520140.1">
        <property type="nucleotide sequence ID" value="XM_025653974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9R5"/>
    <dbReference type="GeneID" id="37157376"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="90" mass="10157" checksum="44AA3B0D8BD7B9E7" modified="2022-01-19" version="1">MFDAMCSGIPYGSSDIHTCACSCLKLLVANVGEVRDKDWQYPCFILVALWIIPYGRMISSLAATIFVRASCWLDRFLRLQCLLLFPASIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9Y2</accession>
    <name>A0A8G1R9Y2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_243282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517377.1">
        <property type="nucleotide sequence ID" value="XM_025654860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9Y2"/>
    <dbReference type="GeneID" id="37158262"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18617">
        <property type="entry name" value="GH43_XynB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF16">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="8">
        <location>
            <begin position="328"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="6">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH59455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="527" mass="60093" checksum="98A9CA3A8033F014" modified="2022-01-19" version="1">MYINPILPGFNPDPSIIRVGKDFFLVTSSFEYFPGAPVYHSTDLIQWTLIGHALTRSSQLQIQTPEPGGGVWATTLRYHDGVFYILAACFQRYRPQEDDRVWPRGFYVKTTDIRDSKSWSDPVYFDQIGFDQDLFWDDDGTVYLSSTYRKLERTPGANLKDFAVHIVTVDLETGASTSEPKLIRESSSGVAEGSHIFKRGKYYYLFTAEGGTESGHCEWVSRSTTGPFGPWEVGPHNPLWRNGVDDDVQNTGHADLVEDVQGQWWAVLLGVRPVWKDGQWEESVFGRETFLAPVDWKDDWPIVNSGQKIPLHSESFYLYELSVPVAWRDDFSDSELQLGWYRKNTPVVRDYSLTERPGFLRLYGGPYNLSVPACPTLFLRKQTHRFCTWETRLSFHPRNQVCEAGAVVWWTYFTYSSVGIRLGKNGQRIVRLRSPGGEVVDFGLRHSQSDVRLVIECGDSYRFGFQELSDVESDDALIEWIGEVDNSSMTAAPPVGVAFTGMMLGLYAFGERQRCLDPADFHYAQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA01</accession>
    <name>A0A8G1RA01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kynurenine formamidase</fullName>
            <shortName evidence="3">KFA</shortName>
            <shortName evidence="3">KFase</shortName>
            <ecNumber evidence="3">3.5.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Arylformamidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-formylkynurenine formamidase</fullName>
            <shortName evidence="3">FKF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_484691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13009"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="3.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the kynurenine formamidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518851.1">
        <property type="nucleotide sequence ID" value="XM_025663253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA01"/>
    <dbReference type="GeneID" id="37166655"/>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03014">
        <property type="entry name" value="KFase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027519">
        <property type="entry name" value="KFase_ver/fungi-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="46"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HGGXW" evidence="3">
        <location>
            <begin position="50"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH60929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="316" mass="34263" checksum="D88F268F44EAFB29" modified="2022-01-19" version="1">MGQTHPSFKPTAPAPPIETLPYGTDHSLQTVTVATLNNDNNEGYWVILIHGGAWRDPTQTATNYLTPALSTLTSNPFYTNNTSHLKGIASISYRLSPHPSHPQDPETTEPTHLRAAKHPDHISDVQSALSFLQEKYNIGRNYILVGHSCGATLAFQSVMGRFRDLLKGEVMLPPPVGIVGMAGIYDLRLLRDTHRSVSAYQEFSEGAFGADEAVWDEVSPALGRGEEGVCGGWSGVGDGDRLVAVLAYSGGDSLVDPGQREVMRKALEEEWVGGGSGSEERVVEMLDIEGDHNDAWEKGEDLARAIAFAIEKVRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAN2</accession>
    <name>A0A8G1RAN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ulp1 protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_482569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520601.1">
        <property type="nucleotide sequence ID" value="XM_025663110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAN2"/>
    <dbReference type="GeneID" id="37166512"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.130">
        <property type="entry name" value="Ubiquitin-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="715"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="557"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="825"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="892"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1112"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="631"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="860"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="921"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="950"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1115"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1136"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1168"/>
            <end position="1181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH62679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1194" mass="133338" checksum="C9724D9331B500AD" modified="2022-01-19" version="1">MPLFKQLSDFLSGRTSSRPPSSPQTSPDPAPPSDATSDHIQRTETSGAWNSGSPIEYGSLHTSLESLDPVTTAFSNAEGLRHPYEHRPVRPQYRQTVPRSDSGMRRLSGDTTHAKSRQRSEAYDELRLFPPNKWNDPGGIPIVPGQTKSNKPKSPFRPVDTISKGRDSGPVRAQGKPNRLRNSQPGNVTGYAGSERPNKRRRQDTLDSSRGNFTKPSDNDVEHPAQEAPRIAGHPPRMSPTLSQSSGKQKKQRNNRRSKVDEYRSTENIVRPSRIQPSPKRGPLPNFGAPSDDDRDERFTKNATKERRRNNSFIADVDSGAEQERPDKHEILQSVEIINAKSQDPANKTKMGLRHDPEIAAKPRRRVSESRESPDELQGAVTVRPPPAQIGDKRAELGSQRTTGREHQSQDIKPTLFEASGPSKKGKRKNKKTKASEMSNQRSFKAKLVRTGPIEQQASDGKSVEVHVDMTKRTIALCQETDSENVFEAPLSKVRQILKAESPNNKVRLVLSKTSELDNRIDIEFMSFTVKEEFCCLLGEVDVRDKSSEWMDKAFNKAQRETKQSTNGMKRPSSESGPEQVPDKQRDTTKRVKLTDNLRDENGVAAGRQPSPPDAASRERANPSLTAPKPNKSNPSQPESSPSRVSKSATDPGVEIPVKKSASSITTRAMSRLPSATTVVCDDSDDENTQPPLPAVNTEKWHKPLVYPLVGKKKAEVDVYDLDRLRENEFLNDNLIGFYIRFLQDHLERTNSDAAKRVYFFNSFFHDTLMNVPRGKRGINYDGVQKWTRTVDIFSHDYVVVPINESAHWYVAIICNLPSLQGIVQEGLDPNEPTPGEKEPSGPPDSQVQEISETPEPEVATDKDKEEKHADGSGPTRAELARRSLETMRIADGAGKDQPAESPAADQEWPELEASPERPSKTLSSLTENATTPEKLDTKEAAQLPEPSAKPRKQKAKRAGPRYDVCQPIIITFDSLNVPRSPTISSLREYLYEEAKSKKGVEIDKGLIKGMRARDIPLQPNYSDCGLYLLAYLEKFVQDPDVFVRKLLQKEMDSKDDWPPLKSGLLRRRLRKFLDMLYDEQEQLKRHEISDKDTMVNKKPVCYLLGSPVLEGAESESKRSPRKKEPSNGSEDLAQAVNSERQSQSEAETSAGQDKPKEIQRSPVVDTTESRHPEASPEKDVVLVPDSQPEAAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBE9</accession>
    <name>A0A8G1RBE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PfkB family kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_445524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520023.1">
        <property type="nucleotide sequence ID" value="XM_025659284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBE9"/>
    <dbReference type="GeneID" id="37162686"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004454">
        <property type="term" value="F:ketohexokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01939">
        <property type="entry name" value="Ketohexokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000072">
        <property type="entry name" value="AT09463p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034093">
        <property type="entry name" value="KHK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH62101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="314" mass="34347" checksum="63B001E461122D23" modified="2022-01-19" version="1">MSLVAIGACYVDTILTTPHYPGEDDKLRASSISHRRGGNCPNSLEVLKQLTTNDSSTTDVSLNLIAVLPAKTSTAAQEIQSAFKPHVDLSHCIFREAFNEPASSYIIKSESSGSRTIVNYNELPEMTVDEFTQIAGNLTNPTWFHFEGRIPDVTLSCIRYLRQRYPSATISVEVEKPGREGLQNLAEEADVVFYSKSWAQGNGYHTAEECVRKESTLTRKASLLCCTWGQDGAVAFEPKTQTSVHSPAYSAAKFQVIDPIGAGDTFIAGMLYALICRGNKWSLSQKLGFANRLAGMKVSQEGFSGLARALESFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCH4</accession>
    <name>A0A8G1RCH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_455631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521591.1">
        <property type="nucleotide sequence ID" value="XM_025661399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCH4"/>
    <dbReference type="GeneID" id="37164801"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="152" mass="17977" checksum="1DEAA3B01F34DE5A" modified="2022-01-19" version="1">MEEKLYREAYEEITWFLHSSPRVKSIAIDRYVDLHKLYQRQPDKHQEAAKYALIVYRLSDFSDDITSKITFSTLEEQHMFLRLLHLDDTNEEYKQLASEKDKIKNEGSLSRSGTTPLSEKNTTPVESWREVDAVLRREFAKIAGHLDLWSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCK4</accession>
    <name>A0A8G1RCK4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FMN-dependent dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_494904</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521104.1">
        <property type="nucleotide sequence ID" value="XM_025663885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCK4"/>
    <dbReference type="GeneID" id="37167287"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000228">
        <property type="entry name" value="FMN-dependent dehydrogenase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="284"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="307"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH63182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="365" mass="40260" checksum="0BFE761686F95B79" modified="2022-01-19" version="1">MAHRGETFHKDVSCIADLKAIGSKKLPKMVRDYYNEGAMDLITLRDNEAAFDRYRIRPRVLVNVANIDTSTEILGTKVSLPFGFSPAAAHKLAHPEGELATSRAAAKYGICMGLSSYSTTSMEDVASQGCGNPYAMQMCVLKDRSLTLQLLERAEKAGYKALFLSVDVPVLGKRLNEYRNDYQLPQDMEYPNILSNGSDTSDRTDYGCLDWDSAIPWLRKHTKLQIWLKGIYAPEDVELAIQHKVDGVIVSNHGGRQLDGAPATLDALRDCAPVAKGRIPIAIDGGIRRGSDIFKALALGADYCFMGRIPIWGLAYDGQQGVELAIRILRQELMITMALAGCRSISEIQRRHLCVLQPDGVLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD82</accession>
    <name>A0A8G1RD82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">3-methylcrotonyl-CoA carboxylase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_444241</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520829.1">
        <property type="nucleotide sequence ID" value="XM_025658968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD82"/>
    <dbReference type="GeneID" id="37162370"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="38"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="154"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="627"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH62907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="703" mass="76929" checksum="BC638B6416C202B3" modified="2022-01-19" version="1">MPLSSLLRTSSRLGPPVVRRFRRAASTVSTTTPKAEKSLDSILIANRGEIALRVGRTAAQHGIRVTTLYTDPDSKAQHALSSPFAFNLGSVSAYLDGDRIIEIAKKEGCQGIHPGYGFLSENAAFARKCTEAGLVFIGPPWKAIEDMGDKSQSKKIMTAAGVPCVPGYHGDNQDVNFLEAEADKIKYPVLIKAIKGGGGKGMRIAHTKADFQAQLQSAKSEAMNSFGDDHVLVEKYITTPRHIEVQVFADKQGNAVALGERDCSIQRRHQKILEESPAPHLPDATRKDIWAKARSAALAVGYEGAGTVEFIFDNDTGEFFFMEMNTRLQVEHPVTEMVTGQDLVHWQLKIAEGAPLPLTQEDVEAFMASRGHAIEARIYAENPDQGFIPDSGTLLHVRTPAATDDVRIDAGFVAGDDVSAHYDPMIAKLIVRGNTREEAIRKLANALEEYEVAGPITNIEFLKTVCRSPDFISGNVETGYIEKHREELFTREKIEPEVLAQVALACLHHDSNPGSGTQANFEGSAVGFGPGYQARQISLAELTPGTKNDSKFDVRVQQTGDDTFNVDVGGRLFEQVVSHRDPASKVVTSFFPHTRLDTTVIRDEDTIIAFQRGTQYRLTIPRAKWMEKALGMKDVTNSVLAPMPCKVLRVEVEAGDVVEKDQPLVVIESMKMETVIRSPQRGTISKVVHKAGVSHAAPTHSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDR8</accession>
    <name>A0A8G1RDR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Core protein II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_409604</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520487.1">
        <property type="nucleotide sequence ID" value="XM_025657439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDR8"/>
    <dbReference type="GeneID" id="37160841"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000021">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000039">
        <property type="entry name" value="Ubiquinol-cytochrome c reductase core subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF209">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="12">
        <location>
            <begin position="57"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="203"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH62565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="459" mass="47811" checksum="7E422B77D7210A72" modified="2022-01-19" version="1">MMLSRSTFSRNAPRALQKQCSAAGASSRRGMASAATPGLQYDVSESAGVKVANREVAGPTSTLALVAKAGPRYQPVPGFSDALEQFAFKSTLKRSALRINREVELLGGEVSSTHSRENVVLKAKFLSGDLPYFAELLAEVASQTKFAAHELSEVVLKTLKYRQQAFAANPEALAVDAAHAVAFHRGLGESITPSTTVPLEKYLSAEALHEYAQQAFAKSNIALVGSGASSADVSKWVGDFFKAVPSGAQLQSAASKYYGGEQRVSTKAGNALVIAFPGSGAFGTAAYKPEASVLAALLGGESSIKWTPGFSLLAQATQGFSQVRASTQNLTYSDAGLFTIALSGKADQITSVGKNAVDLLKKVAAGEVAAEEIKKAVALAKFRALESAQTLETGLEATGSALINGSKPYQIGEVAQSIDAVTEAQVQDVAKSFLSGKASVATVGDLFQLPYGEDLGLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1REE5</accession>
    <name>A0A8G1REE5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_387927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521474.1">
        <property type="nucleotide sequence ID" value="XM_025656691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1REE5"/>
    <dbReference type="GeneID" id="37160093"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="168" mass="19345" checksum="7DCE768D5DCFC633" modified="2022-01-19" version="1">MLFPIPKTTATPTEGEVKIPLLFFVQRIQRYDLHSHTPLPSLIYEVPSDEEAMTLVDDNYSSDALFEWNSERLDLDGFKKFVQEWRNRYTFLDFEFHEALATPDVNDEEGRGGTIGFALKGRVVSKDDGKMYGGKAHAIFKVEWIGDRRVITRNAQVLQGPYVVEDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGI0</accession>
    <name>A0A8G1VGI0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_433150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825099">
        <property type="protein sequence ID" value="RAH51635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509557.1">
        <property type="nucleotide sequence ID" value="XM_025658410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGI0"/>
    <dbReference type="GeneID" id="37161812"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="67"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH51635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="318" mass="35064" checksum="077766CFF31097B5" modified="2022-01-19" version="1">MKSDLVLDRSRWQPQFVTKSTEGLCDLVRKGDEKSAPIFLPSRDPGRMINCRAIDPNNVPSPKGIFLHFHGGGLRSIDALLLRYANSSECKVVSVGYRLAPENPYPSGVQDCFDVADYFVENGPPLRVLGGESAGAFLAMQTIFHLLGTKPQLNTVKALVLAYGCYSWSFLPLAYNITDSVCMNPKKLNVFRNLALTTHPTLTASLRNFDAEFGALQTAEPEIYDSPLKHPVFSPLYRRFESVGARLPPALFVVGTADPLADDTILMSAHWQLAQGSAVTRFLAGAPHAFAEMPMEAGDCCVTYNDLVKEFLYEVIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGL0</accession>
    <name>A0A8G1VGL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_524937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825095">
        <property type="protein sequence ID" value="RAH51725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509647.1">
        <property type="nucleotide sequence ID" value="XM_025665447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGL0"/>
    <dbReference type="GeneID" id="37168849"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH51725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="51486" checksum="EAFDC709D98F83AA" modified="2022-01-19" version="1">MNDFERLRPVGPLEKYSTTRHSLGLYFNVAVSATYILPDTFTLPLKDYVYRACETLIGQHPILSAIPISEDTEDTWFVRLPEIDLSQSVAFQRRTRDFPDNNEPDVELCELLRVQHSTGFAAPLPYWRLFILTDEANDLRFTAVYVFHHAIGDGTSGKAFHQTFLDALHAAATFMTPGEVKQVIQSPTSPLLPNLEALHPCPTTIPFLLNALFRAKVWSHRDPRLWTGAKISAPVKTELSQIIIPAAVSAAFRKNCRQNNATVTAALQAAVARALLTHLPVRYTKVQMNGAISCRRWLKGGEITDQSMGVWVMDFAESFYRNEVNQYPDTFPWDQARKSRTTIEQALGREGKNAGTCLLKHIDNFQDLFRGKIGKDRDESFEVSNVGVLQSKQEEDPSRPQTTRAMFSQTPSALGAALEVSSITGGDGCLVLGITWQTGVVEPELVNAVIDTLVKELHDAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VH12</accession>
    <name>A0A8G1VH12_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma-glutamyltranspeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_432972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825094">
        <property type="protein sequence ID" value="RAH51757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509679.1">
        <property type="nucleotide sequence ID" value="XM_025658400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VH12"/>
    <dbReference type="GeneID" id="37161802"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052896">
        <property type="entry name" value="GGT-like_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881:SF1">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH51757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="510" mass="55172" checksum="8A2ABED292ECF503" modified="2022-01-19" version="1">MFCLFYESKTGKVRGLNGSGRSPMNLTLDIARRNLEISPGQSGNIPLNSVLAVTTPGAAAGWVDTLGWFGSGKLSLAEVLEPAVSLAEDGFPVSEISARLWQENEQSLREASSNFRELLKPDTRAKDGVRAPLAGEIMTNPSLARTFRTLATQGKDGFYRGAVADAIVKAVEARGGFLSHADLVYHVHMGTAETDPVRVQFNGNVDVWEHPPNGQGLVALMALKLLEELERTEQLASFASLRHNSADYIHALIEIFRIAFADGTWWIGDPTFSKTPELLSEAYIAERARHFSPTQASDTMTHGSPAFNSCDTVYFAVVDKDGNAASVVNSNYHGFGTGIIPRGCGFTLQSRGANFTLVPGHPNVLAPGKRPYHTIIPAIATNPDDGSLHTVFGIMGGFMQPQGHVQLLINMLVFGMDAQKALDAPRVCIGPMGHFGSASVYDRTVYIEEGVDMLVVEELRRRGHVVRMMHGWDREVFGRGQVIRAVHGDGGQTVLEGGSDFRADGMALPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VH22</accession>
    <name>A0A8G1VH22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_432871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825093">
        <property type="protein sequence ID" value="RAH51787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509709.1">
        <property type="nucleotide sequence ID" value="XM_025658396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VH22"/>
    <dbReference type="GeneID" id="37161798"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="138"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH51787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="454" mass="51011" checksum="27CE1109C00BD053" modified="2022-01-19" version="1">MSDTPRPSLKLTFGKKKAPEETPQRQPAAPPPPTETPQRKLTLKIARRPAPEAPPEDDKLKKKKKTSKKRPAEGPALQEPSTTVATAQPSGPKRLKLNPSKKPGVQSLRIKNKGLVPNRPVGVGYDSEASDTEIDPSIEEQFILRMLPGEDCEYLQRAIAERRFDRSEISFKPLTREGRRAIFKIRDHQYAAALVDLPCIIEGMKSWDRRGWYKSADICQMLLILGPVANEQEAMDYPLPSDILHPDDKTLQYPHGLTPPLRWVRKRRFRERISTRTIEQVEKAVEDLIAQDEAAVAPIRYELVDKTALNRAEGLVQSGDYDYEDEYDDEQDAEGEMEEGMEDGDAGVYQAGTPMATKPSTPAPESSGDESDGSDDGDEPEDELDDEQLEQQRQMQQQREEIAELEALIRAETAKWEKMQNAILKGKLAKRIHDLKQDLSLKKVSIGEGDDADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHC0</accession>
    <name>A0A8G1VHC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_383895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510382.1">
        <property type="nucleotide sequence ID" value="XM_025656529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHC0"/>
    <dbReference type="GeneID" id="37159931"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="462" mass="52597" checksum="16CBA692EE93EE1A" modified="2022-01-19" version="1">MEGGFSKALFMEKEKGCEVVAKIPCRIAGPAGWTTASEVGVLKYLRRITTIPVPRVLSWSSDRGNPVGAEYIMMEKASGVPLFRVWGDMTEFEKLQLIQNLTKLEAQLSAIRFPAYGGLYLRDHLQSSKPQCLLLDDDVDRSQSFCIGPSPDRQFDVHSDHSKDQGPWTTLSELGISIAKRELSRISTIPNKSAMFYQGTLEEQAQLLNLTISLTPMLDSHPLLGQSAQPTLWHTDLHMGNIYVAPDDRTQIVSVIDFQSISVMPLFLQSRWPEFLKPPDNYTQGFTSPELPDGYDNMDYESKLLARREWSQAKLAKAYEVSTYLEDRPAHTARNVPRVFRELFTRCGKVSEVGVIPLRACLIEIFQNWSNLGFTGSCPYSFSEEEMKTHEQQFSEYQAWHEVQHLAQECLGTDAEGWISPELDIEEKRRQNRELLAMFIERMAGEKSPEEARQMWPFPDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHF2</accession>
    <name>A0A8G1VHF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_454222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510084.1">
        <property type="nucleotide sequence ID" value="XM_025661232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHF2"/>
    <dbReference type="GeneID" id="37164634"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="51" mass="5550" checksum="441842B19310C90A" modified="2022-01-19" version="1">MRETRVLLRTSDNGDGAKSDFIPVHVLLAFCPGCTLHTPFAWQALFGSDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIG4</accession>
    <name>A0A8G1VIG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_500172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512258.1">
        <property type="nucleotide sequence ID" value="XM_025664096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIG4"/>
    <dbReference type="GeneID" id="37167498"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="290" mass="32436" checksum="95D1F712B05259A5" modified="2022-01-19" version="1">MDILLSSYLHDEKARTSIVEPNFQHRLALTQAWDIAQGSRLLDIGCGQGESSLVLALINGSHGQITAIDTAPPDYGGPYTIEQSQKHIQASTLGQRIQFLRTDTAGLLSQPTSTDKYDAAVLCHSLWYFPDRASIAQVFQLLADAKVRYLCLAEYGFRASRPTQVPHILAARAQAQYHSLRKSAATGAREPNVRSALTPEELLDVAHKTGWQEKRSGYIQPDSQLWDGHWEVEFVSSELFRQWIHEEGLSNDAAMDSAIQELEQSIQELGVKGSTRWETMDVFWAVLELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ10</accession>
    <name>A0A8G1VJ10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lon protease homolog 2, peroxisomal</fullName>
            <ecNumber evidence="8">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_378182</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9 12">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="8"/>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513036.1">
        <property type="nucleotide sequence ID" value="XM_025656291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ10"/>
    <dbReference type="GeneID" id="37159693"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000002">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000091">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1480:FF:000011">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.40:FF:000011">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000039">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03121">
        <property type="entry name" value="lonp2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027501">
        <property type="entry name" value="Lonp2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="15">
        <location>
            <begin position="11"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="14">
        <location>
            <begin position="729"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Microbody targeting signal" evidence="8">
        <location>
            <begin position="929"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 10 12">
        <location>
            <position position="822"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 10 12">
        <location>
            <position position="865"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="486"/>
            <end position="493"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH55114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="931" mass="102596" checksum="9EA5A510D269CF9C" modified="2022-01-19" version="1">MGSNSGRTTKLPLVPLPKGSVLLPGITLRIPVSNRPDLANLLSTIVDRSAVAKRDGTPITFGCVPLSSPYLSKDGQRLIDDGSLDDDRREEFEMIDAGQARKEDLFRHGTVGKVIGIQRRAYSEPALVVQGVQRFTVRRVLKERPYFEAEAIVHDEKETVSGDAETVELFQQLRQLSRELLTLLRLSSLLPSPGSRLSPLIARKFELFITKSDVSHAGRLADFMADVADSGFEEKLRILASLDVKIRLERVVEILTRQLQSIKSNVKVTTITTNSFPSSGFDINQIDPRDREILARKAMAGLSGLTPPGLSAGRNNDSDDKESNEVDELQQRLQEAQLSPEARKVADKELRRLRKMNPANAEYGVCRTYLENIADIPWTKMTEDQLGPETLKRARKQLDDDHYGLEKIKKRLLEYLAVLRLKQSTNRDVERQIESLSKELEASDGGDLEKEVPVLSETDRVAVETKLHMLKTRRMGDKSPILLLVGPPGVGKTSLARSVASSLGRKFHRISLGGVRDEAEIRGHRRTYVAAMPGLIVSGLKKVGVANPVFLLDEIDKVGGANFQGDPSAAMLEVLDPEQNHTFSDHYINIPIDLSKVLFIATANSLDTIPAPLLDRMETISLSGYTTVEKRHIAKRHLIPKQIRANGLSDGQVVLSDEVIDKVITSYTRESGVRNLERELGSVCRYKAVQFAHAGDAGRLDAYNPMVSMDELEDILGIERFEEEIAEKHGRPGVVTGLVAYSTGGQGSILFIEVADMPGNGRVQLTGKLGDVLKESVEVALTWVKAHAFELGLTADPTEDIMKNRSLHVHCPSGAIPKDGPSAGLAHTMGLISLFTGKAVPPSVAMTGEVSLRGKVMPVGGIKEKLIGAHRAGVKTVLLPHHNRKDVKDVPQEVSEGLEIVHVTHIWEAIRQVWPDAHWPGQHTNFIESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ16</accession>
    <name>A0A8G1VJ16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_440505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513051.1">
        <property type="nucleotide sequence ID" value="XM_025658772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ16"/>
    <dbReference type="GeneID" id="37162174"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034061860" evidence="1">
        <location>
            <begin position="20"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="129" mass="14218" checksum="9339543E574D6070" modified="2022-01-19" version="1">MLFALLMEFKGLLATSTMAVLTIHKADVIYGVGTGVSREIPDPLSWEANDIWEKLTATLTIVTRRQKVTQTLSIPAWHSDDLLMMVKAIEEEGDRDVAGTGIQCIHPYKFTHLPDKGAHGYLALACGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ19</accession>
    <name>A0A8G1VJ19_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BAG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_88047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512873.1">
        <property type="nucleotide sequence ID" value="XM_025665754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ19"/>
    <dbReference type="GeneID" id="37169156"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039690">
        <property type="entry name" value="SNRNP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14942">
        <property type="entry name" value="U11/U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14942:SF0">
        <property type="entry name" value="U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="3">
        <location>
            <begin position="313"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH54951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="397" mass="43880" checksum="1AF7277CE90EF3B4" modified="2022-01-19" version="1">MSQLLSHISLSSLGETCASYLDHVTTNLPPSLYTLHHQLVATLSSAKDSTPLRLLTPWPELLADHPDGAYTTPVAYTLIVCTIVILVMSWRTPFANFWRRGYTNVDNTPQVTDNDYSYITQDDIVNPPANTYRNQYAGAEDTEPDTLILKHRKEKYDLHFPAYAINDGALSVGQLRQRAAEATRTPDPKRIKLLYKGKLLDNDSLPCRSEGLKQQSEVLCVVSGVEPGESSPSELSEAEADRNTESARQEGSGRKKSGKNKKRNSKNRRKGGKQADGSNTLPPPAEEPPRPSNGAGMPPPAPNLKSFNNPIDQVNALSSYLQRELVPLCEDYITNTPADAKSREFEYKKLTETILAQVLLNADNINPDGVQEIRDARRALVKSAQNALNSLDQVSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ43</accession>
    <name>A0A8G1VJ43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_81366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513126.1">
        <property type="nucleotide sequence ID" value="XM_025665695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ43"/>
    <dbReference type="GeneID" id="37169097"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH55204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="83" mass="9265" checksum="0C10B2D413A422E0" modified="2022-01-19" version="1">MHALLVGAASVNIPLNGHRTVDPRTIPVDYHAFFAVHVSRDLTKEELIALSTWMRKLPSFAGLKIVLLLLFSLQKERTSPSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ70</accession>
    <name>A0A8G1VJ70_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TOR signaling pathway regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_522505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513038.1">
        <property type="nucleotide sequence ID" value="XM_025665264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ70"/>
    <dbReference type="GeneID" id="37168666"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="356" mass="40920" checksum="073AA2D9C17FB5EC" modified="2022-01-19" version="1">MEQPQNLRTLFAEAKAEKSALEARPDSNTDAYRSDVNATIAKLEECQRQVGLLSLFSSNEPLEDISTTDIQYLTVEYHLADLLQRTYSSDREALLRRALGQYERFLARLDDYDVLNEKDKKLFERYTSNPTSFSLTTTNDAATRREVKINRFKEEKELKQKLEYFANNQSRLQSDEEDVRKLYLAEINLYIHQSFQSLDLLSQELTMLSTIRSAPPNPAESLQDDPRRRNQASESSYSERLDRPIAELLRGGKFGPILSKEGKPMQPFTLLDRRTQLQQGVFRSGHNLPTMTIDEYLEEEKRRGNVIEGGGEKSGIKPEVDEDDMDLADEETMKARAWDEYKEANPRGSGNTLNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ82</accession>
    <name>A0A8G1VJ82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_451635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513246.1">
        <property type="nucleotide sequence ID" value="XM_025660633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ82"/>
    <dbReference type="GeneID" id="37164035"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="274" mass="30567" checksum="C22FA22F20187808" modified="2022-01-19" version="1">MADVRSLLRNELAARKGSSQTGSSATNRVTKKRKVDPADDLRRKRMRANVPSGPSTAHTVQPPSARAIEEEEEIEGSEQDIAGPQPPSDIALEQPTAQPDVQPSDTSLVAAEPPAPTTQTIDEDEWAAFEREVVAPTRMPHRPAALAAEATISAAPVSADELAAQQQKETEAIKKSREAEVEGEREDAARFMEDEFDEMEQLEERVRRLKHKREELRKLRIMEDAEMQRMDEPPSAASPSGDQQNPPAGDANEDEDDEDDDDDYDDDWDNWRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJD0</accession>
    <name>A0A8G1VJD0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_499122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513218.1">
        <property type="nucleotide sequence ID" value="XM_025664057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJD0"/>
    <dbReference type="GeneID" id="37167459"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH55296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="688" mass="74055" checksum="E7A6BC0A2E761938" modified="2022-01-19" version="1">MGYIARTNDLPDIARKGGLVDPRAEDQPLFFERMSCRDINEFVSNPANASPLRSGAQSVATKPTSLGMRLREPAIQSQAKVDEFRARSEEIKQRMPVRNPKQPISDLVPGLVVTGGLSRSPAFDCLPVFSHWADRTGELSATDPAATVRLTSTWGTAHVAAEGVDMDSPRGAHAWSLKSHGIGPAEPGASKFSQQYDPETDTLTTTVNVARRQDTPRTDGVLAAVSSVSWMRNARVADAVDCAAGLLADASTLLEARDRIIATGAPERVEFAEVRPVDMPSWCSARKPLAPKLSGVAVASDPTAVNLFAGEDCQGPILNTSVFAMTSGYNRGVYGGSISGLWSTMDASFVMDYSIGVHSAAMADKLTIAFADAAAAAEKSAYAGPHITDISLVKGCNYSCLRQKTVIEDSHPIPSRPTIVVWDDLARLARYKLADAVFCHVYYDGGGSEHMAAIAGLGCVAHDWIDLGADVACGEVSNIIPSLTRGSLEEAPLAEVYARITGAMIWYRENDPYNPAANCLLFTHWWQLSNCRHRPVTLLGRTDLPVDAGIVPIVPDERPPLEHFRANGTKVERGERAIASAEARLEALIASKPLPETRAVIDLLVKPVLAYVRGGNTLPSENEYVGATLAAQVTYPQDQKILEMWDLAIVMWESGALWASGVAGLCYTHAGLSNCDRARKDLSDTTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJD9</accession>
    <name>A0A8G1VJD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U1 snRNP splicing complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_451637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513248.1">
        <property type="nucleotide sequence ID" value="XM_025660634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJD9"/>
    <dbReference type="GeneID" id="37164036"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="277" mass="31166" checksum="66A1C045EA03412D" modified="2022-01-19" version="1">MAAEQRKLLEQLMGADQLIGTGAPSRNAQLQITDPKVCRSYLVGTCPHDLFTNTKQDLGPCQKVHSEGLKTEYETASAAEKAKWGFDYDYMRDMQKYIDDCDRRIDTAQRRLEKTPDEIRQTNNLLKQISDLTKTINTGLLEISVLGETGSVAQALNELHKIRTAKHQKETCERELKNLQDTSGPSGHQKLQVCDVCGAYLSRLDNDRRLADHFFGKMHMGYSDMRKGFKKLSEELKGRPPPVRHHDDDDGGWGGRSGGGRGPRYGGGGYKKRGPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJE0</accession>
    <name>A0A8G1VJE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_428017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512109.1">
        <property type="nucleotide sequence ID" value="XM_025658190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJE0"/>
    <dbReference type="GeneID" id="37161592"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008756">
        <property type="entry name" value="P_tr_PHO88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH54187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="187" mass="20940" checksum="86671D45433A3436" modified="2022-01-19" version="1">MVSPQVTNLAIIVVMMQLAKKVPFEDPDVLMLVRGMYILSNVIILGVYLYTQSKINKKNDLTTLKYVEPAPMGSGEEPKPVTTTNMEYDKGQLRQLMRSQLMGVGMMGVMHLYFKYTNPLLIQSIIPLKGAFESNLVKIHVFGKPATGDLQRPFKANNSFLNQGQIKSDKASVESAEKNWRGGVKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKC1</accession>
    <name>A0A8G1VKC1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_80535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with ATG1 to form the ATG1-ATG13 kinase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATG13 family. Fungi subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513069.1">
        <property type="nucleotide sequence ID" value="XM_025665683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKC1"/>
    <dbReference type="GeneID" id="37169085"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018731">
        <property type="entry name" value="Atg13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10033">
        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 13 N-terminal" evidence="7">
        <location>
            <begin position="78"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="436"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="650"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="784"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="650"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="742"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="814"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="839"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="860"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="889"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="899"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH55147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="965" mass="103583" checksum="11A6961E0A449ADE" modified="2022-01-19" version="1">MHQHPRSPAPAAPPSASRPGANRSDDRRDQDLRPNSPAFDPRVQLTRGLGIETDARSSGQTSTSRPAKEAILKLNQLVSNYHTKAALVILASRIDFSRSDDTPKLNPKVNRWFAIDLEDIDALREELRFWRTNDVSEQLPPPLIIETYLDTKDLTNNQSLVALDEQGKRFDVLESLSRSSEVQAKGPLSSRSEDVILERWRVELGNTPNKALPADLGSNLPKIYKQSIVTFRTLFTYSKLLPAWKLAKRNGRLHTHPALKIRYRILVGKPNPDNSKPDRLTTPLFDSPNRVVDTYTFGTTESPVGYLSIQVTYRTSCEFRVDDSEALLSSRFMGADDEVFRPSLPSRDSNLKAANSGVGSAPVEKRTVEDPDPSRAYGSLSTFHHVGPTTSASPISALRAARESGAASPSPPSSSSRKPVEVVKASPLGRAAVLANESSPGVARRSSISFPPFKAPPLSASPSLVDPPLGMSPRSGTMARPSFPESKNMPPPSMAASARKSLPLPGAPETTATSSNSASPRPTPTARYSSAFTHRRGRPSSGNINKIDDENSSGKTSATSSNPQPGSGLLAEATGTSADSIHADDENITEFLKMLDLRKDLLKTSNSASADVTARRTTATSAALTRFQRMRDSNAQLSESMSSSMLLQRSSTSSSKQLSGVPPMVAGTSISTASSPGKPISPHTPHTPAIPSRLSSNSIVDYGNDRGREQPSSVGDYTPEGPTIPHRPSVATVNAIDIPTSPGLPFPPYRRPSSAAPPPPPVAADDDEIFPFNLRSVSLGAEERSHNSLSALQRQHDLEGATSTTQPTRREQRPPSVSEDPSRRSSSTGLRTSPHKRTSLSGPTATPSPSNNHIYQPRFGLSRGRGLSGGPHSLSSGSSSLARGAPSDLAERDHDRDGNASGSNSGTSAVEDRRGAGRRPSSGRNIPPPPSQAEEDEPLLFAMSDFGASRRSFEEGRHGNQGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLY2</accession>
    <name>A0A8G1VLY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_448338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516201.1">
        <property type="nucleotide sequence ID" value="XM_025659918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLY2"/>
    <dbReference type="GeneID" id="37163320"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="1">
        <location>
            <begin position="254"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="553" mass="63335" checksum="917F6FB8CC000427" modified="2022-01-19" version="1">MAEQFTSLVNTFGGLSVADRSTSNRSNPTQGLLKTIGDLVTSCQSTSANAAHVGTVIEGTQTPSGEYIARLSSLRREAVALANITEKFSDATKDYIMAYLISLASPWTLEPKMLSHFSDEVKRIAGNILDDETTNESSVMRRILEECYAQALCDSGTLHPDEYFEFLEGTSFEEPYDPDFESEEYYEHENRLAIDDSYAEAYRVQCERKAERKEQQREEWIGFWVRALSTCPDEPTTLFYPPASRFPNCHLAEIPRYLFRAFDGESSGRSDHHVVASAESISAESERSRTDILSRPPGESTRMLYNHLKWFKSKDADNLMSWSGSLLYVIQYAIWRCNKWCRDPAEVYIRIVDTRKFPRGQFARDKSLLRVYRDAPESDPSMRSFFDFRLGYPYYDNGEYLSQGVLHHAGRSSVVSLKQLIQAGLYDLYHEFADASARYLWAKRVKSLRSAWSKEHMTTQLDIQYAINMARECFNGFDALDIALVLLTLKKRKLLPIATMGPECRRIYCDLGPVEVQRYTDIMKNIMAKSRDIPIALFAFATDRQLEEIFECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM22</accession>
    <name>A0A8G1VM22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_449281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516098.1">
        <property type="nucleotide sequence ID" value="XM_025660131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VM22"/>
    <dbReference type="GeneID" id="37163533"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="65" mass="7286" checksum="BAE1E482731C8EB3" modified="2022-01-19" version="1">MKLSKSSVEQEGAILPDLADRFEGISLRSPLLSIYELTIEEWIDTAMPEIPASLLQVLMELQKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMG4</accession>
    <name>A0A8G1VMG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_304323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515424.1">
        <property type="nucleotide sequence ID" value="XM_025655358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMG4"/>
    <dbReference type="GeneID" id="37158760"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="26452" checksum="0CB7D11205BCC536" modified="2022-01-19" version="1">MALNNEVPLIPAVQRALAIPEILNHIFECLYHYRPATCSWGGRSILSCALVNKLWFSEAIRWLWQDPRPPLHREGSHDDFVVVLGKIPEARRNLYARYIKRATLLYYKRKPDGPDGVQFPSLRCVHIWGPIDLSDLEEIKFRNNCVRSIWYFIRCPSDTEIEEHATASFEKLLTPLLSHFNHLREWVIFSGRSMDTTQYFKFTPGTEGQGWHRSEHGRVRVPPNQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMJ5</accession>
    <name>A0A8G1VMJ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate cyclase</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP pyrophosphate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO85DRAFT_306743</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515514.1">
        <property type="nucleotide sequence ID" value="XM_025655382.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37158784"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17214">
        <property type="entry name" value="RA_CYR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000055">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000220">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000305">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000580">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013716">
        <property type="entry name" value="Adenylate_cyclase_G-a-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055071">
        <property type="entry name" value="RA_PHLPP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF46">
        <property type="entry name" value="LEUCINE RICH REPEAT-CONTAINING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08509">
        <property type="entry name" value="Ad_cyc_g-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23010">
        <property type="entry name" value="RA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00789">
        <property type="entry name" value="Ad_cyc_g-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ras-associating" evidence="19">
        <location>
            <begin position="615"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="20">
        <location>
            <begin position="1401"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="1737"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="229"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="540"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1090"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2113"/>
            <end position="2152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="384"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1134"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1171"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="2118"/>
            <end position="2135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RAH57592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2152" mass="239023" checksum="AAF38A0FC322BE2A" modified="2022-01-19" version="1">MSHRNSDQSGGRRSSESSGAHSWLSQETVREGRTHQPQHNHEPSNARSVSPLSGFRDTDRPDAQTCTSPTIKDPSDLYSSIFSWGSDFAPKDQRKPPQFGSHRKAMNLLGTEDPGTSPTANSNNRPPQLNLNPPDSSQHDAEPSLASSPTVAPNDGPSTFFNDYSEQEASPASNLFRPGTAQTYASEPLELDYNGDHRRPSVASAMTVSSQGSKSSAGALFKKKLQGFFGDEYVGNGDPRHDSDNFTQNSATKPSSLDQFRARERANSDGSRNPGTSPAPNQARPHTPLPSSEITPWLYQSFNDIPQYGEAPVREAPTATADGQRGSVSQRDQSRRHFSGHRHSRSKEEKPTAAGDLAGYSNRPATGRDDLSLGLRPSREGSLNYPTPMTSTTTLVGRSTSPTPSVQSAYSREQGQNSPGAQTSKRSFLDKIRRPKHGHLKNITGSKAVQETTKAAASKLSRREASPARRGRQGSIESGTSSRLADSGDNERKRDGKGLAISSAKLRGRRGHANEVPPGKEIRQPDRSNVWELDTDLTHMEGIVNPPSPSAKSKMLDGASIRSEETRRRDAVPAGNWDAPESWHVKKQNEPSTLLPQDTSEPGPTITEPDGLNWYIRIFRPDATFATLSGGLYATVADLVHGLSRKSFLTEHISNYELVMQKNDLSRQLDQTEMPILMQKRMLEQVGYTEKDRIEEVGREDHSYILRFTFLPARITGYIIDGNDPLGKAQQKFSHVDLSNRSLVTIPIGLYKKAPEIISLNLSKNLALDVPKDFIQGCINLREIKFIGNEALRLPASFGLASRLTYLDVSNNFLEDLTHANLDRLHGLVSIKMANNRLTKLPSYFGNFQYLRSLNISSNNFKVFPDLLCGLKSLVDLDISFNNISELPQIGKLATLERIWMTNNIVRGALDDTFRDLVNLKEIDARFNEITNIDTLCVLPRLEQVAIGHNAISKFKGSFPKLRTLALDHCPMTQFEIDAPIPTLTSLNIASAKLVQLRDTFFENLPNLTKVILDKNHFVSMSPHIGKLRKLEHFSMIKNPLAALPATIGCLTELKYLNLRECNLRKLPPEIWHCLRLETLNVSSNVLEGFPKHGSPQPQVPSEPIGTPAATPGVSTTPSYEELGALEEQEARRPSQTSGGVLSTGSSPNGGAYRKPSVASSLGQGRKVSAASRSLTDGSPSSRKDSNFSQHVATTFGGSLRNLYLADNRLEDDIFRELSLIPELRIVNLSYNELTELPQGLLRRWPLLTELYISGNELTSLPSDDLEEGSSLRVLHINANRFQVLPAELCKVSKLSILDVGSNSLKYNVSNWPYDWNWNWNRNLKYLNFSGNKRLEIKPPGSSLSNQQQQPKHQTNLTDFTSLIHLRVLGLMDVTLTITTIPEENEDRRVRTSASLAGSLAYGMADFLGKSEHLSIFDMIVPRLKPDKVETVVGMFDGQSQSSGGSRIAKFLHENFIHTFSSELKRMRPEQHETPLDALRRAFLTLNKNMAFACYKSLDQDVRQYQEDSTDQRKVRLTKDDIDLGGVATVMYLNNMDLYVANVGDAQAILVKADGSLRHLTQNHDPAETHERARIRDAGGFVSRTGKLNDVLTVSRAFGHFPMMPAVIAAPHTMHVNLTEQDEMVILASRELWDYVTPDLVVDVTRAERRDLMIAAQKIRDLAISFGATNKLMVMILGVGDLKRREKIRTRPSLSMVGPPEEQIIPSTKRTKKPRDAPGDSRLARFNYVDAPVGELAIIFTDIKKSTSLWETCPDAMRSAIQIHNDILRRQLGIIGGYEVKTEGDAFMVAFSTTTAALLWCFNCQTQLLDAEWPTEILEQPQCQVVYDTENNIIFRGLSVRMGSHWGEPVCEKDPVTNRMDYFGPMVNRASRISAVADGGQIFVSSDFMSDIQRNLEIFADSERAASTGSEESYAYDTLGHNIRRELQQLNSQGFVIKDQGERKLKGLENPEPLYLIYPHGLSGRLTTLDKDASNELAPTTISKHSQLEIQTDLIWRLWEITLRLERLCAALEYPGEARLKEPNVALFNVVKNHGGELADSTVISLVEQQVTRIEVCITTLSIRNMMRPFRPGDQLNDHAVPITDVMQQLQAQLAEFRALKEQIDASAGTATSYTYTDPQYSNGESNYDSASSSYLHMGPPSDEFNPGGPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VML4</accession>
    <name>A0A8G1VML4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_419760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516758.1">
        <property type="nucleotide sequence ID" value="XM_025657873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VML4"/>
    <dbReference type="GeneID" id="37161275"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12538">
        <property type="entry name" value="RRM_U2AF35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000066">
        <property type="entry name" value="Splicing factor u2af 23 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="44"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH58836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="209" mass="24320" checksum="8E02BB27B587391F" modified="2022-01-19" version="1">MANYLASIFGTEQDKVNCSFYYKIGACRHGDRCSRKHVKPSYSQTILMPNMYQNPAYDPKSKMNPSQLQNHFDAFYEDVWCEMCKYGELEELVVCDNNNDHLIGNVYARFKYEEDAQAACDALNSRWYAARPIYCELSPVTDFREACCRLNSGEGCVRGGFCNFIHRKDPSNELDRDLRLSTKKWLKERGRDARSVSRSPSPEPTRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMS9</accession>
    <name>A0A8G1VMS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_459251</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515992.1">
        <property type="nucleotide sequence ID" value="XM_025661642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMS9"/>
    <dbReference type="GeneID" id="37165044"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001949">
        <property type="entry name" value="zinc finger protein 62 homolog isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF20">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH58070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="439" mass="47341" checksum="C4CDF8795C9E47E3" modified="2022-01-19" version="1">MDITTILNRKGSAAMVAADGQFDHQHLVPNPGLDTSSPKMKSEPGVSDAGDQAVLAYPPHGPLGQVPNMAHDMRYAHQAHPGPGLPLLQNPFVPGAYAGGAQIPNTGAPQGRPDPPPKTFHCGTCGKGFARRSDLARHERIHSGIRPHACDWPGCGKQFIQRSALTVHSRVHTGEKPHMCERCGKPFSDSSSLARHRRIHSGKRPYKCPYANCQKTFTRRTTLTRHQNHHTGTIEEAAAETEANLRQNKERARMPGDMFSDHGSVHSTPSPAHHPISPAGDLPPLNMPRSDYYMPNGSIPPHVRGGFTQASPRASPTATSPSLSSYGSAPHPRPSMTSHPSGYGPPQPLEPPANNDHRPNSVSGSPHMTSLGWPSPSHASIPSPGSATDFYPETSGPAYPSAMPPHMYFPNSTIRRPTSTEPDGYDLKHKMESAWSTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNZ7</accession>
    <name>A0A8G1VNZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_369380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517029.1">
        <property type="nucleotide sequence ID" value="XM_025655917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNZ7"/>
    <dbReference type="GeneID" id="37159319"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="60" mass="7299" checksum="4ECA6429009D2B67" modified="2022-01-19" version="1" fragment="single">YYTQITKHKISKEIEEAYSDKNRQDIRYLINKYNLNKQPQVNIPVYIKDIVLFNKIILLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP26</accession>
    <name>A0A8G1VP26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_519022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517119.1">
        <property type="nucleotide sequence ID" value="XM_025665011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP26"/>
    <dbReference type="GeneID" id="37168413"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="62892" checksum="27BDB20747BD3903" modified="2022-01-19" version="1">MPPFGRIPINLSRPQEPQYNSVAFRNVYYDPFLGYAPNPSDDTVCIPFATNRLTPVPVQPGRLEQPGASSTLLTSSSIPAMKIGNNKPGPYLNLTSYPNPISRAAPSNEVPYGSLVRYMEAPTWGVMKISNIPYSITKQEIFQFVGRQARLVAGHAVHIIMERPTAKTMDCFVEFDSTEDAEETANRINRIYECGRAPRLGNRHVEVEISNQEDLLKDLFPRAKCISWENGTPKVVENTDRYSTGFTGFFTSEEIIGAIRHAEMPQRSPFGAKCPQRTYESTISTLYKFPWYATDMYTVHDRNQLFELTNRHIRSLVSRMEKSKTVGLDQRLLRELLYAGLNCPAFNERQKYTLCIHAGEKSEILKLGDMSKWFPFDTLVYLPGFDYDTCAQLYASVIANGRFEGACREFPNNFPADNTTLISPFGRIWFEWPTDVAKNTLWVDAVNRETNVLNCLLQSGSMGTIHRPLSMASTSSSVSPTSPITDKSVPRNENVSRVNVLQASSRRASECWNSGSGSALLDTEGIWGQKVFFSPPKKFRAPSHRITHSSPNCLKDLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP34</accession>
    <name>A0A8G1VP34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine synthase, vitamin-B12 independent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_415681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518303.1">
        <property type="nucleotide sequence ID" value="XM_025657706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP34"/>
    <dbReference type="GeneID" id="37161108"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF2">
        <property type="entry name" value="SYNTHASE, VITAMIN-B12 INDEPENDENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="1">
        <location>
            <begin position="180"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="402" mass="45372" checksum="1F58A428170823D9" modified="2022-01-19" version="1">MAPQLHRNPPFRAEHLGSLLRTEELLKTKTAFENGEVSEAQLDAIENKDVKEVAETQKKLGYAAISDGEYRRHMFWGSFFPGLEGFEEVSDVDADVFRPYAPDVAAFLEAGHKPGETVICTGKIKHVGSTYTKEFKYLASVVPPEEVKNLKITLAAPNWYHLRYKEGKAYPKEVYSSDEEYFGDIAKAVQAELQELYDVGCRNVQFDDPNLAYFCSEKMLAGWKEDPLNVRSADETFEQYIKLYNDSISKRPADMHIGVHLCRGNFVGSRHFSEGGYDRIATKLFKELNVDTYYLEYDTPRAGGFEPLKELPTHKNVILGVVTSKFAALEDKEEMKKRVYDAAKFIAEGNNISLEEALNQVGVSPQCGFASHREGNAIDRDGMIAKLKLVREIANDIWPGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPJ9</accession>
    <name>A0A8G1VPJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Subtilisin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_368290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517689.1">
        <property type="nucleotide sequence ID" value="XM_025655860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPJ9"/>
    <dbReference type="GeneID" id="37159262"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07491">
        <property type="entry name" value="Peptidases_S8_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL C, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121:SF23">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL C, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="652"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="660"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="700"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH59767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="974" mass="108845" checksum="B342387C1B9BA2F5" modified="2022-01-19" version="1">MIFKESLKIFREATPSETANKTDLDLDYDDDDSIEYAVQTSPKDKVQATFDEIITKICNKTLDLRNGSSRAVFLADYSHVLDERTRVDRQTFLHIAASRLAHSTAIRFMVRKKGHLLQYKDANERTPLHVAIVYGNLAFVDAILKEINGTELDILLRQTSENGRNCIHAAIHHFMDHDYALKLIEGTSNTTLSARDKNGLTPLHLAVEYHRSSASQLSLVKALIARGDAALDQFTTDPPGLSVYEYHRYTREKAHMGHQGANAGSSLEILAGKTEDQATLVGGRRALDELPVNQTTTKQQQQIEKCDPRQEPRMNMSRESHTASYADNIQQEIKLYYLRSTFESAPERNIRDQLSATRFLYGANIQNVNLSFDFSQGPLTISQDSFEDSYRHMVFDEVLRYVSFRPVLLQKPPGPAPGSTLAKKLAQTMKEDQGPNDLVFFFNWLYCKNVRHILKVVVHDTEDAPHTDKAIADCLSRFEIETLSWRKVDLSSQTLFNACRGLKEVYLRWSGNPSILTDWTEQDGLLRLEKLECVHLVWNKEEGPEAFHKVTSAVEYLQSRLNQAVEEINAARRTNTKNSNLAQPRKPIVVRKSEIGVSTSKRLKDTASLANMSIGLRKRRIQPNRWLDCIDRFADELQNVKVPVTDTLVLKENIKVAVIDDGVDIHIESLQGKVIGGESFDRTYLDGNGTSPYYISGGGHGTMMADMICRVCPTARLYVCKLEMHPGPEGGGGRQISAKAVMAAVRQEVDIISMSWTIQETDDNQSSITALQDAIRAALDAKILLFGAASDKGAVSEIEYPCSFDRRIFRIGASTADGRVYGPSGNPQHLSFIFPGHKISPRSPYLEKGLPIDSEEKSGSSISTALAAGLAALVLHCIRLGVIQAEMETRLTGRCSSTAVWLSDMEKARNFYGMRSIFRGMGLNEDNQRYIEVWKRLDGPARRLRSPGGESVDMTGLEIIAGLARDLVSGIADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPZ0</accession>
    <name>A0A8G1VPZ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_517787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518139.1">
        <property type="nucleotide sequence ID" value="XM_025664937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPZ0"/>
    <dbReference type="GeneID" id="37168339"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034045982" evidence="1">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="107" mass="11706" checksum="F132A1E7BE15E4D3" modified="2022-01-19" version="1">MQLLSILPIAALAGTSIAVHWNVTLYTDTECTEYKWSYAGNQSYGCYSLETYNPTIQSIRAEIPEDWVFDGASGGACNNFHTFGGSGCWTQGQGQGFKSFQVYPKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQC9</accession>
    <name>A0A8G1VQC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efflux pump dotC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dothistromin biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_392851</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Efflux pump; part of the gene cluster that mediates the biosynthesis of dothistromin (DOTH), a polyketide toxin very similar in structure to the aflatoxin precursor, versicolorin B. One function of dotC may be to transport early-stage dothistromin biosynthetic intermediates from the cytoplasm into vacuoles, thereby affecting the rate of dothistromin production.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518662.1">
        <property type="nucleotide sequence ID" value="XM_025656857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQC9"/>
    <dbReference type="GeneID" id="37160259"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="101"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="608"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH60740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="632" mass="68481" checksum="D4F073A3E35B0F68" modified="2022-01-19" version="1">MAVTQDPPREDDRIAQQQQHADQDKDVLVDAEKMSPSDVGSSSRDGSEKPDPVGSPSQTSTEQPSPEETGDVSDEKAGAGAPLDRVPSQAQKLGKKKIVVVMTALCLVLFLAALDMTIVSTALPTIATHFHASESGYSWIASSYMLANAACVPLWGKISDVWGRKRIILIANFLFLVGSLICALAINLPMIISGRAIQGAGGGGIIVLANICVSDLFSVRERPMYYGLFGSTWAIAGALGPIVGGAFTTDVTWRWCFYINLPIGGVSFVILVFFLKIETGKVPFWAGIRSIDWTGNMLMLGGTLMFLFGLEFGGVNYPWDSPTVICLIVFGVFTWGLAVLNEWKFARYPVIPIRLFNNTHNVLMLLLCFCHSMVFISGSYYLPLYFQTVLLASPIMSGVYVLPTVLSLSIFSAATGFVIKKTGRYRELIISGFALMTLGYGLLIDLKYYASWPRIIIYQIIGGIGTGPLFQSPLVALQANIHPSDMAAGTATFGFLRQVSAAISIVLGTVIYQNVFHEQMPKVAAAIGEAKATSIENSFSGSASTLIKSLGSAQKTVVLKAYTLALSRMWIFYTAMAGLGLIISLFIRPVVLSKSHTIAKTGLAEQEKARQAVLEDQKRQRGEEEKEAKEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQE3</accession>
    <name>A0A8G1VQE3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc finger CHCC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_509641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518589.1">
        <property type="nucleotide sequence ID" value="XM_025664506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQE3"/>
    <dbReference type="GeneID" id="37167908"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000003">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="2">
        <location>
            <begin position="215"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="292" mass="31709" checksum="66EE87C764678B40" modified="2022-01-19" version="1" fragment="single">LKTDSQQNGRDCKAEIPRRQNPTASAAGAPPIGRRLKRSSSRKLETSSNLSPTRVLSSSPPLHPPATLESHSGPQLPSMLPCFRSRVATLSSTFTPRFAARASYSTTVPRLSENFIPANDPTPPTAKPNVSGTNATPVDAMGGWDAPLREEPEAGERTRHLQAPNRATTWAASQQPKEKAMVGPRFEQTIMELQPQPLAAIELIHRQPVRWTKKRVVSCDGGGGPLGHPKVFINTDKPEIATCGYCGLPFAHEQHRAYLKSLPATSYPLEPTGDAAEVNESQRVTEGGFEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQN6</accession>
    <name>A0A8G1VQN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_369120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516880.1">
        <property type="nucleotide sequence ID" value="XM_025655902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQN6"/>
    <dbReference type="GeneID" id="37159304"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="202" mass="22968" checksum="7B635A0B0EE48896" modified="2022-01-19" version="1">MEASEEAFQELVEFNEVTFTSNETVNRIVRILVFNYLVEQEDGFFYPSLTDDTGGLRESDIQRDNRSGIVQSVMYALGIIARVSDPKVLGIGWINTSDQLLLREALEAMSRPEDLVDIRAFKMYLEQEWCLAITSRIEHCGQSGVSQEGGDNEGDKKEKINWGKHFLGELYPLELTHLQNVLKGFFPADSENVWGAQYQHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQS3</accession>
    <name>A0A8G1VQS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sterol desaturase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_446215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518979.1">
        <property type="nucleotide sequence ID" value="XM_025659456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQS3"/>
    <dbReference type="GeneID" id="37162858"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="153"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="348" mass="39700" checksum="F3E4D3454E55F5AA" modified="2022-01-19" version="1">MNRVLALPALFFCLFTYTPSYTTFNLIFFYMTWTTLILSHSPFKVELFGSIGVRLLFYILPSALLFLFDALVPSAAVLLKAHGEQGLPTGSKRRGVRGRELKVVGWSFLNIFISIAVQATIETLRIGYFNTRSALKVSFSIPIIPWNIAFHLACVLLLREILAYTIHRFILHNDKYRITRYISSLHQTWYHSLHAPYPSTAHYDHPIPYLLGNAVPTLLPAVFLRLHMITYAMYLSIVSLEETLAYSGYSAMPMDFFLLGGIARRVEKHLLNRAAGNFGPWGIADWFCQTTISEEEGEELIAETEDEGDEPTPVLRGKEIFEAKVQEALDSHAKKTQRKHKKKLRQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRE3</accession>
    <name>A0A8G1VRE3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_474359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519699.1">
        <property type="nucleotide sequence ID" value="XM_025662658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRE3"/>
    <dbReference type="GeneID" id="37166060"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="6">
        <location>
            <begin position="239"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="697" mass="78915" checksum="DD6102A7440B6F45" modified="2022-01-19" version="1">METSISELVERLGSDEDAVRKMAVFKLQGSIGDPSFADNFIAEGGLTRLRYLTLHASGNTLAYSLTSFARILEVDKGWDLVDQDMVERVVELIVTHPLVNILRGAMSILVSIVSHPYSGNHLSQDGNFGFRALKPAIAIYPQFLEMLVNRLSSADHALCANALQLINSLMRDSITNEADTEWPKFIQKLQDLGVIRAVYSLMQGTALQDHVHPLIEFQSLTKVLLRKWREIPLDLERPEHRRALKGIYVASSHERSQEKGLDNGDEMKQSKKHSSEKWRRLGFETESPSMQFEDTGFLGMMDLADYVRNHQDEFQKMLLEQSTKLPQQRCPIARASLSVTSILYQHFEVDKSEMDDSKGYLLLESRSNLDKLFEPLLLHWTRLHVAGLHAFFRLWKATGAEVEDYGKIVELVRILIESVVGGAPRTKDVQEVEEELTNFEYGRLRELQMELLGLTYEDAWGQHLQQMREELYHEALQFVKEQRIRCLLHGAWFLNEGSDSSDVGTEQRSWKYAQLSHNRRFLHFGDFNSILERCPELDTLPEKIDLSSVSSVVSNVSASSNDQSAEPAKDMSHAVSYTKITVHGYSQPVHGTGDIQKSNGHRRTSSRSVQGETALLSFCPQSTSVASEWLDGLLMLLNQQPITAETNKLISLVSDYGLKIRLLNVRFDDVAFAGEAPQVPTRDGLDDNYYYDVFGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRN0</accession>
    <name>A0A8G1VRN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_486367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517840.1">
        <property type="nucleotide sequence ID" value="XM_025663386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRN0"/>
    <dbReference type="GeneID" id="37166788"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF64">
        <property type="entry name" value="IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="369"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="506" mass="58268" checksum="0E00D422370575A8" modified="2022-01-19" version="1">MSSTKTYLPTEILRQIIHHLLPQLYLPELLRARKVNSLFNEEIIDYLINGEDLEELFTFLTKEKLNSSPWGTFPDRLKRLYLQRKLREHSHRPCAFTYFVQEVIEYQLGDAPALEDKEKLTEGLIDVVIAGNNDPSNMFHRLVCQWWIDKVDNRFNEPIEKSMPIILACMAILRGDCAELSTALRNGLDPEQPCLRFGVIPINVAAQRGNREIAKIMVEHGCSMWYTWIYNIPMNALAMAAISRNKEALGIWLEHHHQEEHADPTKPFYVCRQAFEKLARRGDVELMEFFVERYPRVLNDLLGPLRLAVCFTQLAAVRWLFARLSAPLTPDQGRLLLLRAMEGPCAWQRISQMVQLLLELGVSPNGESRHRTPLQKAVIAGQEEIAEILLQNGADANEYHPRSATVGRQAPLMLAVRQRSVSMVRLLLRHGANRTYVMKRKRYTIHENRGQVQNMETALIGLGWEEEQVRRHEGWDYWVLSEKLPPVTPKQENKSGVPGKAFQSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSB8</accession>
    <name>A0A8G1VSB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_386404</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520702.1">
        <property type="nucleotide sequence ID" value="XM_025656629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSB8"/>
    <dbReference type="GeneID" id="37160031"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000009">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8 11" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="11"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH62780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="373" mass="41265" checksum="45B5CFB473BBE7BE" modified="2022-01-19" version="1">MADSERRPRVFFDIQIGKQKTGRIALELFNDVVPKTAENFRALCTGEKGMGKQGKPLHFKGSIFHRVIKQFMIQGGDFTAFNGTGGESIYGEKFPDENFDLKHDRPFLLSMANSGPGTNGSQFFITTVPTPHLDGKHVVFGEVINGKSVVRKVENMSTQADKPTTDVTIVDCGELTGDEYENADKQIPDATGDPYEDFPDDHQGEELSAPVCFKIATELKNFGNTAFKSGNLTLGLEKYQKGLRYLNEFPEPDEQDPKDLDPQMKALRFTLHSNSSLLANKLGQFKNGQTWATYALETAAAANAKDADKAKAYYRRAVAYSGLKEEDEALKDLQEASQLAPGDAGITNEIARVKKAVKDRQARERATAQKFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSS2</accession>
    <name>A0A8G1VSS2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_411009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521167.1">
        <property type="nucleotide sequence ID" value="XM_025657507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSS2"/>
    <dbReference type="GeneID" id="37160909"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000021">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000015">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="290"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="827"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1137" mass="127224" checksum="30CB6A695ABF8DF1" modified="2022-01-19" version="1">MMQWTSFVQKAQSFIDPANFTLPTLSSSDRNPSKASLFRQQFRLPDSQNPLQEITAELILPIPHTSSPSHGESNRPFVERPGNRYAGRLHLSERFICFSTQPTSFAPSASLGASTHWAGQTNGTGPSGNGFTIPLCCIRRVERLNSLSHVFSLALTTWNGALGKQSPDFVPQRFTIQLAGSRQACERFCDGLKKGLRECMKEIENLRVVVNDCYSEYLLSGAKSKAQNGDTTEQRQPPDAGLGMIFRYPGDARKLRDRSKMRLWGEYFRENGRNATIIRQPTFHKLIRVGLPNRLRGEIWEVTSGSLYLRLRSPKLYAETLSKFSGQESLAIDEIEKDLNRSLPEYAGFQSEEGIGRLRRVLTAYSWTNAEIGYCQAMNIVVAALLIYMSEAQAFFLLSVLCDRLLPGYYSTTMYGTLLDQKVFESLVEKTMPVLWDHLTKSDVQLSVVSLPWFLSLYINSMPLVFAFRVLDVFFLEGPKVLFQVGLAILRINGEELLDIQDDGSFISVLKAYFSRLDESAHPRSENPKLRAITRFQELMVVAFKEFSQITHQTITEQREKHKDAVLENIESFAKRTSIRNLGPDSKKLSMDDLGVIYDRYYEVLYDHQQRQKLLDEEKRRQEKKRVERTSILGPPVDREVGRVGLGPSPTHMDYDAFREFLAATAKWAVADSPPSRKESAEQGFNSLKGWGKPASLWNNKPEAADHEFTRRLFRKWATDPDEGLSLQNVVNGLARLKGPRDIMNNIQYFFDLYDDEGTGRVDREGILRMSEALLFLSRRGFDGAISPTQSVEDIKTSERDPDRLSTDERFLGSVSSFIRRCFEYADPSHPDSRAAEEQKDQADAEETADKLGSFSIGDDDEEDLIDVNEDTKSTASAETETPAKQSNEDKSNTQHNRAVSESANPALDPNNPLHITLPTFRMVILADELLEQFFDTFFPQSFRLSDHGSQALASASLSSNLTTFSNIGVPKPQSSAAAGASVAGASGGIVPPGKGLRGVLDNIVSDGIRMAAEVKKRMDEAQRELERTALNRDDDEEDEEEEYDGRGGVASASAMVGGISSWGAGAYGADPERRSVRDADRDLLEGAEVISMRGKDDASLLDDRDEHEHTTAQGSQSPHEPSQAEHNVISKVEFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VTA4</accession>
    <name>A0A8G1VTA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_363683</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519535.1">
        <property type="nucleotide sequence ID" value="XM_025655667.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37159069"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="18"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="987"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2514"/>
            <end position="2592"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="987"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1150"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1019"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH61613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2596" mass="285053" checksum="3E60A1C0F389CA33" modified="2022-01-19" version="1">MVYFSESRVHDAPGENILAPLAVVGMSLKFPQDATSPEAFWNMLIEGRCVSTEFPTNRMNIDAHHDAERGRLHSVTCRGAHFMKEDLGLFDAPFFGITDADAKAMDPQQRLALETVYRALENAGLPIKQVAGSKTSVFAGSFCSDYHMLQIKDPLNVPKNATAGTGRNMIANRISWFYDFLGPSATVDTACSSSLMAVDLACQSIWGGDAAMGVAIGCNIILAPEMTIGLDNLGLLSRDSHSYSFDKRANGYARGEGVGAVVIKRLDDAIADGDTVRAVIRSSSSNQDGKTPGILQPSKDAQARLIWDTYQKAGLDMGVTRYFEAHGTGTPIGDPIEARAIGTAFRSYRSEETPLYVGSVKSNIGHLEGASGIAGFIKAVLVLEKGVIPPNSSNLQNTNPQIDEDYLRLNIVKSAIAWPTTGLRRASVSSFGFGGANSHIVLDDAYNSLRLSGSEIVGHQTVIVPALGQINGIPQLNGHHSTNGVDKFNDSTIACKTVPKLLVWSAADQAGIKRLAESWSTYLASLSVEEPEEYLRDLAHTLCGRRSHWAWRSFVVAKPGVLLQDLTNQFSPATQSVDSPHLAFVFTGQGAQWYAMGRELIGHYEVFSRTLTELSAYLKELGCSWDILEELQKSGLDSNVNDPTYGQPLCTALQIALIDLLESWGISPAAVVGHSSGEIAAAYSSGALTKWSALKVAYFRGSLAGVLGRSSSMKGAMLAVGLSKENVQKYLDTLEFQSDGPEVVIACVNSPRSVTLSGKLEQIDALHGLLNRDGVFSRKLAVNVAYHSFQMREISDAYLTALGGLEAPRNRKRRRPFMVSSITGTLISSEQLMEPEYWVNNMISPVLFHDAVSYLCSQSGEKYKKIDGSHRHAVKIDHLLEIGPHCALQGPCRDIVSVLGKSDKVSYVPFLVRNRSALECAMEAAGRLHCSGYPIKLTAVNGDGDAKARRRPRVLVDLPEYPFNHSTSYWHETRLSEGYRFRRYGYLELLGAPEPNGNPMEATWRNIIRVSDIPWVQDHKINGTILYPGAGMLVMAIEAIKQLADSDRLLTGFNIRDAVFSTALQIPTHAEGIEVNVHLKRTKEGRSDATGWFEWRIYAYDNGNWVENSTGSIQALYESRSSSFDADVREEREWENHLLETYNSAVRSCTSAVDAKSFYKHLNSCGYQYGPEFAAIQSLGYSESDCKALVTDIRTFQPTGVYPTHTIHPTTLDAIIQMAAGLESTMGQSATNVAVPVRIDRLWLTNSGGLSHPFADAVRVCATFSQSVIGYKSYSMTAVDMEVSKALLKLEGLKVTAIVGGGTTPVSDQFMTDSLCHYIAHKPDIDLLTSEEAQSLYGVHDSQVKEPVEYYTELDFLAATCVSRYAASFREEERNNMPPHLNKYIDWALEVKRTLDQGLSEYSSKQWLDRMHDDDYVSKLHKRIESGSKRGQLTSTLCRNLAGFVNDPLSHLFGNNLLSDVYREMLCADSIKSRLDRVIGALGHKNPRMKILEVGAGTGAMTDSCIRALSMDSPADPNLRRYSQWDFTDISSSFFPGAQEMFAAEGQRMRFKILDIEKDPEIQGFECGTYDMVVAFMVIHATKDLVVSLSNVRKLLKKGGKLLLFEITHLHPLRLNLIFGLLDGWWRSTETYRQTGPCISSEKWGELLKETGFSGCDVVVDDYKADVCREGSMIVSTAVAPVPTDITAVNIIINPEDQTQADLAAAISDRLEQLSISRITLTSMTDIAQRELSANLLDISLLEATTPFVCDMDSSEYESLQALVASTKSLIWVDEGGGRQPHPEYRLLDGLFRALSGEMYRARLTNLSLERHSSREHKAAQICKLVLSVIGDVERGADTEYTEIDGILHISRLVDARSLSQEVARKALPQHEELLPYGSGPSLRLKIGSPGLLNTLHFIEDRSLEKPLGPKDIRIKVKAAGLNFRDVLVALGRLESDTLGAEFAGEVVQVGDQCQKFRPGDRVVAFHACRYANYVTLREDMPIVGIKDEKMPFTTAAAIPVAYATAWLSLTKIAALQAGESILIHSGAGGTGQAAILVAQYLGATVFATVSTEEKRQLLMDRYNIPTEHIFSSRNTLFAKGIRRLTADRGVDVVLNSLSGDGLIASWECIAPYGRFVEIGKNDILSNSKLPMHPFERNVSFTATDLAGMSIDRPHIIRAALETVFSLLEEGKLGLIYPLQVRGIADIEQAFRQMQTGKNSGKTVLEMRDTDEVMTVLDTQPTYTFKPDATYVVAGGLGGLGRSVSRWLVERGARNLILLSRSGPASLHARSLVDELHARGVRVITPACDITNRELLKTVLEVCSQLMPPIKGCVQASMVIRAHNFESLPYQSWKETTSPKVQGSWYLHELLPRGMDFFVLMSSVSGIMGVVSDSGYAAGNTFEDGLARYRVGIGEKAVSLDLGLFLTAGYLKENPESRELFLSKTVLNEIQESHLHALLDTYCDPTQGPISMQESQVVVGITPSRQKLKTNKAEWLDRPLFRHLSLTDGSTESRGNSEDSSNLAALFAGASSTEEATAIAMRATREKLSIMMSTPVDEIDTDKPIHQYGVDSLAGVELRNWFARELRADLAMFDILGGASLASVVTLAVGKSEYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQK4</accession>
    <name>A0A8G1QQK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_524878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palC family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825093">
        <property type="protein sequence ID" value="RAH51789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509711.1">
        <property type="nucleotide sequence ID" value="XM_025665442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQK4"/>
    <dbReference type="GeneID" id="37168844"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.280:FF:000005">
        <property type="entry name" value="pH-response regulator protein palC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037505">
        <property type="entry name" value="pH-resp_palC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="379"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH51789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="517" mass="55964" checksum="D6CA42D317D84AB8" modified="2022-01-19" version="1">MVYAFTLPSTSHLSFQTFLTSSTHPSLPQAATTARHALRQALKAHKRLPRGPQQDAHLQTLLTTITSYLPYLLALSNGLSSKPGDTSPTEEIEITLRTEITSAWRPTLTNPTTTLSLKQRPTTTRIQGQGLDFEIAFVLSTLSYVLNSLARIGVTRTLYASTTPTPEQRTAAIQTATKHLLQASAVHSLLASSPSFATAAHSICNSNKNGTSTLPDLDPATQAALSCLALAEATLLAVLKDDSYVAACIQARNPNDKDWMVRAPEIPKVRAHLFARLCIRAAEYAEQAAAGLGSVRSEGRMGIDDDLLGYTRVLGRVARARACRFFGVDAELSGKIGEGIAWLRAAKGALGVRGAGTGGAEAKETSTKSRTGLSRLKQGWMERREERRMEKDAGSRDRIEKGELGPGDNAGREEESRVIEMLETKWVRMNDTINTQLIPPSTDLLANLPSGRDIHSAPAPYKIPSLDEEQLVRMRAPPAEDDFGPGSDVEDSDEEAASVARVYTPGTVPERSDSAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQU6</accession>
    <name>A0A8G1QQU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_208281</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510060.1">
        <property type="nucleotide sequence ID" value="XM_025654591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQU6"/>
    <dbReference type="GeneID" id="37157993"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF47">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="12">
        <location>
            <begin position="171"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH52138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="439" mass="50255" checksum="7C685F51387C4CD0" modified="2022-01-19" version="1">MAVRRFRRITILASLLGVFLLYHFLSIRPELYTRSATQLRTPQTTPQSAPNEPPECPPLAGIEDVLVVMKTGVTEALDKVPVHFQTTLRCVPNYIIFSDFEEEIEGVKIHDALRTMDGTVRDTVADFNLYNRLREQGRAGLESADFADEANSNIGKPNNPGWKLDKWKFLPMVQQALTYKNNAKWYVFMEADTYFSWPTLLEWLSHFDPKEPHYIGTETQIADVIFAHGGSGFVVSNPAMQLASNEYATRTVELNEYTDWHWAGDCVLGKVLADAGVPLRYSWPILQNSNVGELDEFAKGFYRKPWCFPAVAFHHLTSHEIQDLYEFEKRRRRQATSNILLHRDVFKELIYPELSNVRDSWDNLSDEEHPKITDFHECKTLCSSSRSCAQFVMRDGICFTGETPRLGVRNPTARSGWILSTVDHMMDNAPRCPHPDFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QR67</accession>
    <name>A0A8G1QR67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_431996</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a role in autophagy. Functions at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. Also plays a role in mitophagy and regulation of filamentous growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510065.1">
        <property type="nucleotide sequence ID" value="XM_025658362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QR67"/>
    <dbReference type="GeneID" id="37161764"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2570:FF:000001">
        <property type="entry name" value="Autophagy-related protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039113">
        <property type="entry name" value="ATG29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040666">
        <property type="entry name" value="Atg29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039362">
        <property type="entry name" value="ATG29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18388">
        <property type="entry name" value="ATG29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Atg29 N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="89"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH52143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="420" mass="45783" checksum="A992F05E9A913BDE" modified="2022-01-19" version="1">MTSFNQSGDTKFTVFIRLPFPRGDFVDPPPMEWNAAKDQALWNILSRPSKGDDLDWKALADHFDVTLQFLLQQAAWLYDRQLSQVRAQMSRVPTTQSTSTSPAPGSVSGSTALGQQTKGATNAGPRAPSRLSSQQKDGLPQRAPIPRRTSSTTTVNQVKSAREPVRNDTPVAEPREPRRESYASRPSAGKREQAAAPPVPKSPPLEDDTTSSSSESESDDDNAFGSRRGLRFKPPFGKFSTHRAGLRYDEEDDDESPAFLPEPERASHEASGQDLNATLRMNAEDASESHRRPSAPMISRTSVTTESSASSASSGVPVAHPQSDRRRRLNQSGGPLSPRRTGELAHFSPRQSMALRRDASDGTPSMGSSFSDLDDASVTQSALEEALLSNIQHGGMASRMSTISQAIRSRYLGRTEDRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRE3</accession>
    <name>A0A8G1QRE3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar complex-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_453940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510345.1">
        <property type="nucleotide sequence ID" value="XM_025661164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRE3"/>
    <dbReference type="GeneID" id="37164566"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:DNA replication initiation"/>
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    </dbReference>
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        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
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        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBF"/>
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    </dbReference>
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        <property type="entry name" value="NOC3p"/>
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    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
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        <location>
            <begin position="125"/>
            <end position="217"/>
        </location>
    </feature>
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            <end position="678"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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            <end position="61"/>
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            <end position="112"/>
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            <end position="375"/>
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            <end position="473"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR028977"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RAH52423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="689" mass="78519" checksum="28BB1623BC35F371" modified="2022-01-19" version="1">MAPARTTKRRRVSPPGDEERGSKSSGGASASDFYSNAAEWDLEQDYEQRPRKLGKKDKEQTRLPIKTAEGLQNVAEPEPEPEAEESDSFLGTDDDEDMEDADSDEDEEEVEEEKPKIPLKLQIIQTKEELARLATLINEDPEENMPLFKTMAEIMERGEHVAIQKLALAAQAAVYKDVIPGYRIRPLGDEDLSAKISKEVRKLRTFEQSLLSNYKHYIQKLVELTKPAKKDGPQVDPGLKSIAINCACNLLLSVAHFNFRSELLKILVNRLARKQVDADFVKCRETMEEVFIRDEDGVVSLEAVRLLSKMMKAKEFRINETVLDTFLHLRLLSEFSRKASRDRIDREEEEETPQFGKKPKQKREFRTKRERKVQKERKAVEKDMKEADALVSHEERDKNQAETLKLVFGVYFRILKLRIPKLMGPVLEGLAKYAHLINQDFFGDLLEALKDLIGHADRAEEEEEEEETDETNEAEPATTRDAQREALLCTVTAFALLEGQDASKAASTLHLDLSFFVKHLYRSLYNLSINPDVEFNPDKSLRLPDPNSPEANPAYRSRKKVNFQTPMVLLLRCLQSTLISRAHGMPPPVRLGSFSKRLMTSSLQLPEKSALATLSLMNQVARHNARRISSLWHSDERKGDGVFNAYATDIEATNVFAGTIWEGELLRQHYCPQVRDAALDVEKMIATRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRU3</accession>
    <name>A0A8G1QRU3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_505903</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025664355.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="37167757"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Isochorismatase-like hydrolases"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH52678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="188" mass="20760" checksum="90817571D5D5EC23" modified="2022-01-19" version="1">MATEKAALLLLDVQNGIVNRLENTSQYIQTLSTVTQAARNAQLDIIHVVTAFRAGHPECNPRNPSMARAKEMGAFRNNDESTQVHPAVAPRDEEPIVTKYRVSAFTSTELDLILRSMGITEVVMAGLITSGAVLSTVRAAADLDYSVTVLEDGCMDRDLEVHRVLMEKVFTRQGRVVSSKEWMDEIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS07</accession>
    <name>A0A8G1QS07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HLH transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_239652</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="RAH51777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025654826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QS07"/>
    <dbReference type="GeneID" id="37158228"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000111">
        <property type="entry name" value="HLH transcription factor (Hpa3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF15">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="355"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="470"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH51777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="503" mass="54703" checksum="0D596FCA5B857DCC" modified="2022-01-19" version="1">METTLAHRPWEPATTGPQTPPVSSTQTLPSISTLTASMAGGMPTQAEKSPGNASLNTIERDSGNWSMPQSTRSSTYSTTTNATGNYPSLSFLTSQPSPNRASYVSDRSPYPNDHSNTHTPSSAGAQPSPNFGSTQPNTTLPSINQNYDAPSQRGSMVEPPESRRSSVDSRMNQGISSLAINPASPYHSTNASQTSIVSGLQRERGISMDVNMNNSYRGPRYSGGQPLSPLGPRASEHRGFAAGRTAPAISSNPRSEIYNAEAPTAGLAYAFPDPDVARSNSVSSTTEKSTNQFSRKGSTAESLASSVFSDARLPRGQHELPQNVHHHSLQHKQVRGLIGEADAHSGSTPYSRTPELRVTHKLAERKRRSEMKDCFEALRVRLPQSQNNKSSKWETLTRAIEYISHLEKMVTTTRRENDVLRSELDEMRAQLSQQQANGQSRQPSIFEHHPITAPQPNGQVHGAMFSGYAPGTAMPQEQPRTLPPLMNGTVAPMQGVQYTDERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSH1</accession>
    <name>A0A8G1QSH1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_508149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510033.1">
        <property type="nucleotide sequence ID" value="XM_025664444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSH1"/>
    <dbReference type="GeneID" id="37167846"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26916" checksum="5D462979443B3EEF" modified="2022-01-19" version="1">MDQPTHIIDPEGEVIIVLRNANSPFAPDDYEDMNTEADALELPETDGEQPAGQTDEKRLAKEQPPETPAEDAPLSETPEENHFRIRVSAKHLMFASPVFRNMLTGGWKESMTYLSKGSVEITAESWDIEALLILLRAIHGQQSEIPRNLSLEMLAKVAVLINYYDCKDAVSILTDLWINALEEKVPESGSRDLMLWVWVSQFFKLSSQFITSTSNAMSQCDGLITSRGLPIPEKVIRLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSM4</accession>
    <name>A0A8G1QSM4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cora family metal ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_216897</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825092">
        <property type="protein sequence ID" value="RAH51839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509761.1">
        <property type="nucleotide sequence ID" value="XM_025654650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSM4"/>
    <dbReference type="GeneID" id="37158052"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000014">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="841"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="876"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="461"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="499"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH51839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="904" mass="102381" checksum="1AACA1998DF1F2A4" modified="2022-01-19" version="1">MQPSPSTPHQTAPSPSKPSRHSTRRAGDSQLAITRGYETPGSDRKQDDGAGSRSGTTVKSAKRKKPRHRKRRHRRQSFLGGAEDPHPAAPHASIPDAGEDISMMADQTKPQASLPFYKLGSRDLSSTSLESEALLDHRHQPSMRPRRDSRLAQSYRPGSSTTPFRPESGSQTLPSAHRSYRVDNDSGGEEEEVNDRTPLMPPPSGHSPSLPRYGADFRSSPLSFHQRRPASSRSSSSRCSPRAIPSPKFGEQQDRDYDINNPPSMPTSPKLGPEMNYDDAVVTGAEFDFSLAKSIDNRMEQLARSHDVLIDVDGTNNRPAQSPGSSPTSPQINPQERLRRRTTFPAEEDVCFPTEEVSEIAEEDAQRAAKEGHRRRRRLREWPDLSVLEDWSRQEKEERSGAYRAKKISEPMLVEGRLRPQYRLWRREEEEAPYRFTYFNEEFQSTIHAQTISELCQPGGSFRELFIPDPPELDISSDEEEEEEEHHQRESTTDHNNHSRQPSGNVSRVMSPNGNSHGANGNGIHNPNNHQGVYGNQRHQPRTSIISEAVTEARTSAEASPLRKPAQPKPKRYGPRPTFWLDVLCPTDAEMRVLAKSFGIHALTTEDIMMQEAREKVELFRNYYFVNYRTFEQDPNSENYLEPVNMYVVVFREGVLSFHFSQTPHPANVRRRIRQLMDYLILSSDWISYALIDDITDVFGPLIQAIEDEVDEIDEKIMQMHADERGMGPNKEEDNQSVTTSLAPGEMLRRVGVCRKKVMGMYRLLSNKADVVKGFAKRCNEQWEVAPKSEIGLYLGDIQDHIMTMTSSLTYYETLLSRAHSNYLAQINILMNERQEQTADVLGKLTVLGTIVLPLNIICGMWGMNVKVPGQDVDSLSWFWSITAGLVLFAIASFYIAKRVYKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSR5</accession>
    <name>A0A8G1QSR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DNA repair protein Rhp26/Rad26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_492639</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510896.1">
        <property type="nucleotide sequence ID" value="XM_025663788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSR5"/>
    <dbReference type="GeneID" id="37167190"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22254">
        <property type="entry name" value="CSB_WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18000">
        <property type="entry name" value="DEXHc_ERCC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000039">
        <property type="entry name" value="DNA repair protein Rhp26/Rad26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058951">
        <property type="entry name" value="WHD_Rad26_CSB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25875">
        <property type="entry name" value="WHD_Rad26_CSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="438"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="770"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="210"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="958"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="999"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1082"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1132"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="96"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="970"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
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            <begin position="999"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1103"/>
            <end position="1116"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH52974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1224" mass="137067" checksum="FD9C54063B6F63B5" modified="2022-01-19" version="1">MDDANVNDVDVAASKNGSDEEIKKEEQPEQQATSASDLPKSEASLNQGHSANADEASRLRELQADVRDQDDLERDISRQADKLLMEQADERDSKRLEKTTLEKQKLESQILKLHQRLSQPVGTSARVRIRNEIEKLESRNAALATDLTEIQQRMDERHQGQEAGSQTTGTGRMPNESRRDYLIRTGKITPFSNMSSGPNHGPLASLQDALIDAEDERDEREALEQVKNRSAVSHRNLVRPGFGFDETPESSIVDEAPTSRASKRRKIDRESYDDEQEDFEQDTKVSFEDNFEDQDESASYVESERQSSVSEDEEEFLPEEKPKRTAKPVKAPKSSGDVEDFSGMDDGNEQLYQTRLQYWVSQRAAARKRALEVHAESHGSEEVAAGDTVDVVDQDEQEEWFMPHPTVADMPYDNGYRIPGDIHPLLFDYQKTGVQWLWELQQQQVGGIIGDEMGLGKTIQVISFLAGLHYSKKLTRPVIVVCPATVMKQWVNEFHRWWPPFRVSILHTSGSGMVNIRNESSREDALLSQSWNSSSSRGMPSGLKAARKVVKRVVEEGHVLVTTYSGLQTYASLVIPIEWGCAVLDEGHKIRNPNTSITIHCKELRTPHRIILSGTPMQNNLTELWSLFDFVFPMRLGTLVNFRNQFEFPIRQGGYANASNLQVQTAAKCAETLKDAISPYLLQRFKIDVAADLPKKSEQVLFCKLTKPQRQAYETFLGSEEMKSILNGRRQVLFGVDILRKICNHPDLQNHKLMSSTAGYGGGSKSGKMQVVKSLLELWKDTGHKTLLFTQHRIMLDILEKFVNSLSGFNYRRMDGTTPIQHRQAMVDEFNNDPSLHVFLLTTKVGGLGVNLTGADRVIIYDPDWNPSTDVQARERAWRLGQKRDVTVYRLMTAGTIEEKIYHRQIFKQFLTNKILRDPKQRQTFQLSDLHDLFSLGDEGQGPTETSKIFKDADVTYEDSDGASRRSKAATKSSAASHSAQEEKKDISKVVGVAAVEQFQGEPEQQSSEQEKGTSGANSESRIMEGIFARSGVHSALEHDQIVNGKRVVRADPKIIEAEAKRVAAEAAEELRRAGEAARSVPIGTPTWTGQFGLAGKPEEQLPSRPAFRGSSSAARRAVAGPSSASILANLSARTPSPRSSSNSPAPSRTPSGVDFITMIRDFITAQGGSVYTQMLIDHFNRYCTTPQRSAEFKEMLKTIAVLDKGGRNGRGKWALKPEYAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSS4</accession>
    <name>A0A8G1QSS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-methylsalicylate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_382911</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-methylsalicylate + H(+) = 3-methylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:23112"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17231"/>
            <dbReference type="ChEBI" id="CHEBI:36658"/>
            <dbReference type="EC" id="4.1.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:23113"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.52" evidence="7"/>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510911.1">
        <property type="nucleotide sequence ID" value="XM_025656487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSS4"/>
    <dbReference type="GeneID" id="37159889"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047596">
        <property type="term" value="F:6-methylsalicylate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF29">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="25"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH52989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="349" mass="39138" checksum="6813AAAB6988FB77" modified="2022-01-19" version="1">MGEHVRDWLRDKAVGWSHTPPVNKIDTHHHLVPPFYAQAVEEQGGDPSGWPTPSWSAIASKQLMKRVGVKTAVLSVTAPGACIAPERQSRAQLARRMNEYAADLRDKDPDHFAFFVSLPDILDTEDALAEIAYGLDTLHADGVTLFTRYGPSNTYLGHKDVEPIWAELNRRGCVVFIHPTHPVDIHPVNPKLPQPAIDYPHETTRTAMDMITSGTRLKYPNCKVILSHAGGALPYLISRVTTPMKKAPDVAVSYRIGTTHDKAMEAFRSFYFDLALSSSPQVLDMLLKMVPHDHILYGSDFPYAPITAYPAFLEELENYQMNPELRDMINFKNAWKLFPRLANRTGPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSW0</accession>
    <name>A0A8G1QSW0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_453339</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511170.1">
        <property type="nucleotide sequence ID" value="XM_025661029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSW0"/>
    <dbReference type="GeneID" id="37164431"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000021">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF236">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="153"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH53248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="267" mass="30057" checksum="FCF00C640153D455" modified="2022-01-19" version="1">MPKKTSNSKQRQQPPSSTPKSHLQKHQQQRQQPPNWPPLRPLIPSTSLTLDPLVPDQIYLIRNFFPSTLCKTYTSFLASLPLTTTPGKPKKGDAVRVNDRFQIQDEGFAEGLWSGTALKEMILNAGGDGEDEDEEEEAVTRDMKDIWGGEPIGLNGNIRIYRYSKGQFFDKHYDDSNAITFSSPGRPPRAARTTWTLLIYLTSCEGGETVFYPEATRSNRNPEPVSVAPVPGMALLHRHGDRCMLHEGKEVREGEKWVLRSDLVVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT69</accession>
    <name>A0A8G1QT69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_453967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510363.1">
        <property type="nucleotide sequence ID" value="XM_025661170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT69"/>
    <dbReference type="GeneID" id="37164572"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01821">
        <property type="entry name" value="Rhamnogalacturan_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034802291" evidence="1">
        <location>
            <begin position="16"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="33"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="259" mass="27815" checksum="9E4E017B871BF94B" modified="2022-01-19" version="1">MKLSFLSVFLTSVLALPSSLSSRNDIPPFFLLAGDSTTAVQSSGGGGWGDGFINTTLHKGAKGINYGHNGATTVSFRSGGDWATVLSKVGEYKSDYRAFVTIQFGHNDQKASANISIAEYTSNLEQFAKDVKNAGGTPILVTPLSRRNYDNSTGTPLVIENLADQRAATIEAAKNTDTSYIDLNKASTNYLNSIGPADAYTYNLASDDYTHLNDEGSIVFGGMVASLIDQDFAELKSDGYVKVKAKLLTALEKGEYYWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTW3</accession>
    <name>A0A8G1QTW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol 3-beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.173</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Autophagy-related protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BO85DRAFT_442897</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22724"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:37424"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.173"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:22725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61836"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:52973"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:61837"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.173" evidence="4"/>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510768.1">
        <property type="nucleotide sequence ID" value="XM_025658859.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37162261"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13215">
        <property type="entry name" value="PH-GRAM1_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13216">
        <property type="entry name" value="PH-GRAM2_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000303">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000560">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000029">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048066">
        <property type="entry name" value="ATG26_PH_GRAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048065">
        <property type="entry name" value="ATG26_PH_GRAM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF25">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="10 25" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="24">
        <location>
            <begin position="261"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="55"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="434"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="549"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1294"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1294"/>
            <end position="1307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RAH52846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1340" mass="149845" checksum="42D8E36EFEB76EFA" modified="2022-01-19" version="1">MFASVLPERLREDDDSQVDFSAPPGGMGPREGHMQYMHQSIFGMIAAVGSRSGFHAQFDESSDSEGEDENRVRKDAQNLSATAGALPIRSGNESPRLSPKPQSPNPERGRRHRRTISDNKLLRPFKINSRQNKGQEPAVQSEPPTGDEMSRASTPKRPRSATPRAAPVLSRMVEARALLDTEDSTKGAPSTTDETRDESGKQSSASALSLRLKEMFGFEAPEKVLVEYACSFLQSMLLQGYMYVTEGHICFYAYLPRKSTVAIKSGYVYKRGRKNPKYNRYWFSLKGDVLSYYADPSKLYFPSGHVDLRYGISASLAEPKDKGREVKDFQVTTDQRTYYFRADSSSSAKEWVKALQKVIFRTHNDKGSVKISFPIESVIDIEESPMVDFAETFKIRVVESEETYAIDEYYFTFFNDGQDAFNFLRGLVADTPMKRSQQTLSPQPEQTSRSRRTRASQNRWSITSGTSQSRGIGKSGNRRRSASTGQFSFGHDALSMSPPMRQQDSSLSFGNSFEQATEASGILQSMTDTTESASQILNRSDVFQSPTIRTMRRGPSGAEKTVRRHSDETARSVHTTRNGPEIQYAVSESDRDTQTPTGLHPSTSALNELARAGVYPLQRAAGFAEYLKTRSKQMSNLLASESMGYLEKVSGMWAGGGKHYGESENILADDQAVDPEDLEAGCKDGDRFREHFALPPSEKLQASYFAWLHRMIPLYGKIYISQKKLCFRSLMPGTRTKMILPLKDVENVDKEKGFNFGRHGLVVVIRGHEELFFEFGTAEIRDDCAVTLHKGLESTKFLMASGLLAECEEKDESESARAEHRLLQEARLDITGMQSSRSAMTESNELHPIFDDPRASIINFKPTESLRITCLTIGSRGDVQPYIALCKGLLAEGHRPKIATHAEFEPWVRKHGIDFALVDGDPAELMRICVENGMFTYSFFKEATAKFRGWIDDLLSSAWKACQDTDLLIESPSAMAGIHIAEALRIPYFRAFTMPWSRTRAYPHAFAVPEHKMGGAYNYITYVMFDNVFWKSVAGQVNRWRKKELGLKATGLDKMQPNKVPFLYNYSPTVVPPPLDYPDWIRITGYWFLSEGSDWTPPAELVDFIQRARKDDKKVVYIGFGSIVVSDPSALTRTVIESVQKADVRCILSKGWSDRLGDPASAKSEVPLPPEIIQIQSAPHDWLFSQIDAAAHHGGAGTTGASLRAGVPTIVKPFFGDQFFFGTRVEDLGVGICLKKLNVTMFSRALWEATHDERMIVKAHKLGAQIRSEDGVDTAIQAIYRDLEYAKTLAQARSNVSSTPFSPTPSAKTVAEQEADEDVPEEEWTIVEDDTELDMRPTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTY4</accession>
    <name>A0A8G1QTY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein-ER retention receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_173411</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510704.1">
        <property type="nucleotide sequence ID" value="XM_025654294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTY4"/>
    <dbReference type="GeneID" id="37157696"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="250"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH52782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="38676" checksum="6003B81DB09F7837" modified="2022-01-19" version="1">MLNLNIFRLLADLSHISSKCVLIWAIHRNKSAEGVSLLTQMLYALVFVTRYLDLFSKAGWRHFYLVFFKLFYIISSFYVIYLMMRVFPRTRERERAWKMAIISVALSLVLAPISIVIFYRGYPDRWFTETCWTFSIILESVCVLPQLLLLRQTTVPTVIDSYYLLMLGSYRAFYILNWLVRGLGSEGHWDVIADLYGVIQTAFYVDFAWVYYTRQRVKLRNGGVVDSEDFRHSWLVSKILNFRQRRSADEEQNLNEEDVEDEEVAGGGRPRNNRWGARGISVSADDTLGNHRGTGQDESLEGFLEDEEDDDDNNGYPVNGGAHPKQSTGVTGSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUT5</accession>
    <name>A0A8G1QUT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_214327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509787.1">
        <property type="nucleotide sequence ID" value="XM_025654632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUT5"/>
    <dbReference type="GeneID" id="37158034"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH51865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="475" mass="54240" checksum="891AFA920401445B" modified="2022-01-19" version="1">MEIGLFGPSLYCVERGEEIQKQLVSSVLAIPGLRESWVPTVGPQLFHPENPVGSYDKHMKSYPKEEGLAWTRTLKDFSNIPRPVKAPPRAGLIPRGRLHLRSMAEGYDVPDTPFWHAVAEVTYGYSWCLIDNNVFCKDCLLGTGTCAILASFPDYYHFCQDMYPVLEMSAQRLVEYIAHVDRCHPDGGEHHKVMDAWLTTAQSTYLDVLHPKAERMKGPEDELQSIRYRLINSSARALTLQARLEQGSLIGDDIIIDAVAIAKIFMHDACDYRHDNAANEFYNIITVVTSHRGVPANNMFRRFCIDVWAWAVDNGADWAIYIAGRVLAWQVYMERYRTPILFDNLVPRDANTQPTDDPYGDPILNSMNPLPPSSDPHDFDLRNRCRNKDRYDELLRNCLAHFETCPGCHEYDKKTSWADRVPLLGKAYETKYTDCSCLNIISTYMVLACMEPVWWVMDHAAEYTGPTEKWSPLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUW9</accession>
    <name>A0A8G1QUW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_492134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511229.1">
        <property type="nucleotide sequence ID" value="XM_025663762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUW9"/>
    <dbReference type="GeneID" id="37167164"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="196" mass="21769" checksum="0D976853E2A42603" modified="2022-01-19" version="1">MDANQVEVLQIRPDQIVKTSHENLVNLEEAYLGHRSIVIAYDSYGISLEEIRRASNIFFNDASAVACICRELLKGLKYIHDEVGITHGNLSCCTVVLTDRGQVKITDVGDGMVRGRGTDDRTMDNRAVGQIAATLLRLDCLEEDLSGPHLEAESFIHVSSIATVDELLNHRFLQAGFEPWCLQSLAILSKVIRFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV90</accession>
    <name>A0A8G1QV90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide-N4-(N-acetyl-beta-D-glucosaminyl) asparaginase amidase N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_384692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509997.1">
        <property type="nucleotide sequence ID" value="XM_025656559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV90"/>
    <dbReference type="GeneID" id="37159961"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021102">
        <property type="entry name" value="PNGase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056948">
        <property type="entry name" value="PNGaseA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31104">
        <property type="entry name" value="PEPTIDE-N4-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25156">
        <property type="entry name" value="PNGase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12222">
        <property type="entry name" value="PNGaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034643580" evidence="1">
        <location>
            <begin position="22"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal" evidence="2">
        <location>
            <begin position="31"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="559" mass="61707" checksum="8E8EA1B03C4046E9" modified="2022-01-19" version="1">MLVSFGVAVYLVSLLFSPARALLEVFEVYQPVPTGHGSVGCNEEVLLMDHVFGYSYGEPYVGIYEPPNCTFDTVRINFTVTSKGRQYDRLALMYLGDTEVFRTSTAEPTTDGIIWTYIKDMSQFNVLWKEKQKLIFDLGNIITDVYTGSFNTTLTAYFSYESNVRTPDVILPISARKSAQNASSDFELPSDNATVQYQIPQTASRAVVSISACGQSEEEFWWSNVLSADEYTFDNTIGELYGYSPFREVQLYIDGVLAGVDWPFPIIFTGGVAPGFWRPIVGIDAFDLRQPEIDITPFLPLLKDNKSHSFEIRVTGLSVADDGTVTFANTVNSYWVVTGTIFLYLDSSSSSESHSTTTGQAPEIYAPAPTLTVTRDLTQSPNGTNETLSYSVTAERTFTVKSSEYSWSQNLSYSNYGYLNQQGLSQKNNQQTSGTNTITQLTGNNKSTNEVTFQYPLICNTTYGLEDGLSISAWIRRGLDISSTGGDGELGVSTYTFTSGPLDLHTEQYGTAYYFEPEDDESSVSYGETVDVWGSNAGGVEYSRNVRAVNGTVVSDTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWB3</accession>
    <name>A0A8G1QWB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_451969</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512985.1">
        <property type="nucleotide sequence ID" value="XM_025660713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWB3"/>
    <dbReference type="GeneID" id="37164115"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF27">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="777"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="813"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="919"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="978"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="777"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH55063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1023" mass="112407" checksum="DF985D64F007E6F8" modified="2022-01-19" version="1">MTTARGAKPPVSARPSQPSPYPPISTTASSRGFVPSFSPEHQQDQTLWPTPSASTPFLPNDDPGLVLGVPAPIMIPPESDESPLASGLTLGHDDIVLPEDLDNHSRASSRDPGSAVTAGDPGTSHESGIDAHRDDGRGDPAHNHDQQGGEKPAWSEMKTKAGKERKRLPLACIACRRKKIRCSGEKPACKHCSRSRIPCVYKVTTRKAAPRTDYMAMLDKRLKRMEDRVIKTIPKEETRDMGAIGRSVVRPPQPGQTNKAQKKRTAEEAFAAEMDEWARESRNGPQDTFPMRRESKPGDASGLMSAGAEFLPSLEIQEHLAEVFFDCVYGQSYLLLHKPSFIRRLKARTVPPVLILAVCAVSARFSTHPQINSEPPFLRGENWANPAAAIALSRHDEPNITILTVFLLLGLHEFGTCHGGRSWSFGGQALRMAYALQLHRELDHDPLLIQNNGNGSQLSFTDREIRRRTMWACFLMDRYNSSGSQRPPIGNEKFLQIQLPIKESHFQMEIPGPTEDLDGNVLNPVPDDVGQLSNAKENMGVSAFIIRAVVIWGRIVDYLNLGGKRKDTQPLWSQESGYMRLKRQIEEFSASLPSHLLFTYENLQIHAADRIANQFIFLHIIIHQNMLFLNQFAIPLSPGGRPPRDMPKAFLSNAGRAAVEAAHHISILIDRASAYPLTVPFAGYCAYSASTVHIWGIFSKNAQLEARSKENLRHTYRYLNKMKKYWGMFHYMVESAKDRYRQFADAAIKGTVVMQNGGQIAPMFQYGDWFDKYPHGMSRSHWEEPDPQKAKSDDGVMSQRPDLQSVEEFFASLSPTPQPSAPRRHSKKSSKADSVSGFDGPTPPQSMNEIAMDGAPGMLGTTGTGFPQPAVFNQNRAGQQPFAQPGFDFSMPAADQLPQLDRQFVYGSFGDFDPSASLVPPENPAMPAPVNRPEAPPNEDPSTIFTGQLDPNAPSGAGEYYQPSAWFLPFNLDPVGAGGGLDPNSQAAGSGNPVVGGPDLSGFGNIPMGTFDLGLGVNRGSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWF6</accession>
    <name>A0A8G1QWF6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_86643</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512825.1">
        <property type="nucleotide sequence ID" value="XM_025665743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWF6"/>
    <dbReference type="GeneID" id="37169145"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="601"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH54903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="656" mass="73352" checksum="89DF09A2623784CD" modified="2022-01-19" version="1">MLMDQRTRLRKACDACSIRKVKCDTSGPPCRSCASLDIPCTYERPSRRRGPPNRHAEAFKKQKLAESPAGSPSPSDHATPGPPGSVGSTTIPSSTPAPLSAESICSMPTLWLLIDDFFTYIHPLVPVPHEPTFRAALERRDDLSNPTFLALTAAMVGTLVASFPRRPKRHLKTEAEKAAFPHSMALVRRCHDVAVQARGYGYLDRSATVYDAATSYFLGLCAGYVWHMRRCRAYFAECLTMIHVYDLSRQSNHFRAMTPPSPSSSSRYSQDPFGGATADLHVDIIEQELGRRLFYTTIAGYRTLQQLGSGDVTIHVPPETPTSRYPPLPLEVDDEYIFSTHVEPQPSDRISLLVGFNANVRVFSSYNTLSAWETAFGSGQVFDWERQRSLMWECLQKAKSGLSDVPRELAIQLSQDPEMGNGHGQYETTPPVEDPRARKRHMQLQIQKANIYASQLGTRSYLVEKYWTLYGAWKMQRKQSDQQIPVSPRTTIKVEGEPPQSLDTYDAEAQSDYIGRMMGEERRVVIRDLFILLQSVNESSMEPNGGSFTAKIRQIASTLLNFPHHSMITPSTSGPQPLTSAEAEAYLRAFIDTLVRLEGFKSGPSQGKSGSSPEVHRQSISYLSDHNRDEEELRQWASLKEYQAKFAEAGGMLSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWL0</accession>
    <name>A0A8G1QWL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_140307</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512099.1">
        <property type="nucleotide sequence ID" value="XM_025654069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWL0"/>
    <dbReference type="GeneID" id="37157471"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="12">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH54177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="326" mass="36576" checksum="942E411E5CE13852" modified="2022-01-19" version="1">MALGRTFKLNTGYDMPAVGLGTWQSKKDEVRDAVIAALECGYRHIDAAAVYGNEQEVGDGIRQSGVPRKDIFLTSKLWNTHHHPENVEEAVDKSLADLQTDYLDLYLIHWPVAFRYSTNTIQPVNEQTGLIDVVDVPIKDTWAAMEKLVEKGKVRSIGVSNFTREKIEELLETSKITPAVNQIEAHPFLQQKDLLEWSTQKGIVIAGYSPLGNNIYNIPRAVDDPLVIETAKKLNKTPAQVLISWAVQRGTVVLPKSVTPERIESNFQDFILPDDAFSTIQSLERHQRMNFPARIGVDIFSEVGEESVRKSALAWAEEQRVLKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX58</accession>
    <name>A0A8G1QX58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_83067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513251.1">
        <property type="nucleotide sequence ID" value="XM_025665711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX58"/>
    <dbReference type="GeneID" id="37169113"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="391" mass="41809" checksum="6D86FBF65C925426" modified="2022-01-19" version="1">MTDPTSDAPAMDEFAQTRGGDDLFDDEIVPVPAVEQQPEPEVHTEPAPAPVVESDAPPPARTDTPSSRSRGGERRGRGRGRGRGGRGSHNGGRRGDGAVKNKPVESAPEHENKNEEGSTPESPAEGDQNGKEETTASDPKQAAAPEGPRVPAVRGDRSATGGLKKPKLTEEELSRRIAAAKENAAKVAAAHARAEADQASFLEREKVAEEKRRQERQHRKAMDNERERNRLRKLGALNGREWDAEKKEEHYNPRGGRGGFRRGMHGGVSGYARRDFDSQPSEEASEDARPPHHRGRGRGGRGGRGRGGHRGPRGDIAASDGAADQPASGETKPKASAPVINNESEFPSLPGSEKKEKEKAGEEAPATPDLLKSDSLSPVAGASWADQVESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX80</accession>
    <name>A0A8G1QX80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_382484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510957.1">
        <property type="nucleotide sequence ID" value="XM_025656467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX80"/>
    <dbReference type="GeneID" id="37159869"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="87"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="579" mass="66464" checksum="60D75293501AD6A7" modified="2022-01-19" version="1">MLRKPVPLLRGQRRPFHHPTFSYRTNLSQSCPFSWNAIHEPYDYTRARFLVNENHEMAIRRVKFNMSELVKRAAESVGFSHDQCVNVERLPDGMFNKAFLFTMQDGTQVVGKVPNPNAGRPHYTTASEVATMDFVSKLHTTRFTGVRNKLSTPVPKVLAWSSNASENPVGAEYIIMEKVGGIQLNKVWPRMNIKQRFELVMTIARYQKAWMSKSFIQYGSLYYSKDLQSNSGCILVNEDGSRFKDDRFAIGPSTGRGFLDDGRIDVDFDRGPWDKLYGYKLAIGFRELACVQEMPQLPRSILGLYGPGTYRRSPSKKIAAIRDYLRMVHFFLPADDSISSACLWHPDLHVANIFVNPENLSEVVGIIDWQSTEVLPLFDHARQPYFLDYDGPPATGLDPPDFPRDFDQLNPDEKIKAERLYLNMSLTTLYRKLTYGKNKRLFKAMEFQQTSSFDMMLFAQNLLIDGEALYRARAIELEEEWSCLPGVQAFGNPPFPLQYTTGEVRSIHEDADKASRSMELMRGVKESLGELWPEKGIVPLERYDEARELLKHVKTDLINQLANSEEEKTGWDKAWPFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXE2</accession>
    <name>A0A8G1QXE2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zincin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_453509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511047.1">
        <property type="nucleotide sequence ID" value="XM_025661071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXE2"/>
    <dbReference type="GeneID" id="37164473"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="285" mass="31566" checksum="85652B0BFCF862CF" modified="2022-01-19" version="1">MPDIRGTTLTPSTSKIDYLEALQEAVGSRGLKTLAPDSVDSPELQNLRRSLANSTATAPGRYTCSSEKPLPVTIRGINNRATLQGGFRGVIPRWKPDNPPQPINFAAFANGYPRPGLALLAANALRDAANDWNKLDLGVKFEWVEDISKASFVLSYAGNQEGVLAEAFFPNEDDLSYLNVYSAAFQPGKIQYLKNIFLHELGHVLGLRHEFAPELEDTKDDFSVQFGPRNPLSVMGYEFPPQLQTSDIDSAQAFYRFPGSELGWKEAHVPRPKRKMLPIKDCTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXR9</accession>
    <name>A0A8G1QXR9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Iron-sulfur clusters transporter atm1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_376200</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513765.1">
        <property type="nucleotide sequence ID" value="XM_025656214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXR9"/>
    <dbReference type="GeneID" id="37159616"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140466">
        <property type="term" value="P:iron-sulfur cluster export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="138"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="460"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="45"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="702"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="705"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH55843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="721" mass="79786" checksum="C563D8F248CDE725" modified="2022-01-19" version="1">MLPRAARTPCWRASGRFLHHTSAVPRPTSWASASYGFQLRSFSTTRSPLRSQTSQNIPSKSQTPEPKDPSTTRPSAANVAQSPPGTQNATATPKKDLLSEATVGRKEQRKADWAIMKEMAKYLWPKGDWGTKLRVGTALSLLVGGKILNVEVPFYFKNIVDSMNVDFSTFGGTAYTVAGSMIIAYGVTRIGATLFQELRNAVFASVAQKAIRKVAGNVFKHLLQLDLNFHLSRQTGGLTRAIDRGTKGISFLLTSMVFHVVPTALEISLVCGILTYQYGVQFAAITAATMVTYSAFTIMTTAWRTKFRKQANAADNRGATVAVDSLINYEAVKYFNNEKFEVARYDKALKAYEDASIKVTTSLAFLNSGQNMIFSSALAGMMYLAANGVASGSLTVGDLVMVNQLVFQLSVPLNFLGSVYRELRQSLLDMETLFNLQKVNVNITERPDAKPLQLKQGGEIRFENVTFGYHPDRPILKNASFTIPAGQKFAIVGPSGCGKSTILRLLFRYYDVQEGRILVDGQDVRDVTLESLRKAIGVVPQDTPLFNDTIAHNIRYGRIEATDEEVHQAAQRAHIHELIQKLPDGYKTAVGERGMMISGGEKQRLAISRLILKDPELLFFDEATSALDTYTEQALLQNINSILKEKRRTSVFVAHRLRTIYDCDQILVLKEGQVAEKGSHRDLLEQNGIYAELWNAQEMSLAQDVDSEPTAAEEEESTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXT8</accession>
    <name>A0A8G1QXT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_497099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514303.1">
        <property type="nucleotide sequence ID" value="XM_025663982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXT8"/>
    <dbReference type="GeneID" id="37167384"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="325"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="568" mass="63990" checksum="A10BD190A8F11EBE" modified="2022-01-19" version="1">MSTTRPKYETIETNVDNYTRIKNIYILMRDGIELCADVFLPLTASENGEKVPVICSMGPYGKDNHASTFGLPHSPIYAEMYKHIKPLGPDACFELCDPSIWCKEYNYALVRVDSRGIGGSQGKLDPFGLGRSVQIQADAEGQDLYDIVEWAAIQPWSSGKVAYSGISYYGMVGYWAAMQKPPHLSCVVSYESACDMYQASRRGGIYSDNFQSHWYRNLVIPYQGGKKEGRIGEAELSANRVDFPKLLSETEYPTDGVWEVLERARNISDIEVPFYLAGNWTDAELHLPGNIRAYNAISSEYKWLEMHTGNHISAFYEPAHLEMQRKFLDFFLFGKDNGMLDVPRIRLLQHHGTNTLYRENETSFPPADAEYVPFYFTPEKVITPNKPTGPKTSFTYEGYSENLHFSLESPFPESFELLGSPYLELEVSTTAKDMDIFIYLRAINADGENIILHGNHGEPMDNFARGYFRLSHRDEVAKGFIEDKVISQPAVAKSEVIPGQVYSVLIPLYPAAFLFDQGQSLSIEIGSVDTAGTIGPMRHEGGDRVKERFSGDNVIISHGKLVLPRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY15</accession>
    <name>A0A8G1QY15_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_376727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513574.1">
        <property type="nucleotide sequence ID" value="XM_025656234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QY15"/>
    <dbReference type="GeneID" id="37159636"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="108" mass="11879" checksum="E7604814056D6F36" modified="2022-01-19" version="1">MRQENTGSSLNGDPSRRNQSSQSARLEPPNDSPQTSDQLAEELVYYRSFLEQLLGLVRNGDQDTVNQMVSMIRSDATHQQILAALSENSANDGQTAQGAHGRNNHNPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY88</accession>
    <name>A0A8G1QY88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_490729</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512999.1">
        <property type="nucleotide sequence ID" value="XM_025663671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QY88"/>
    <dbReference type="GeneID" id="37167073"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH55077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="266" mass="29187" checksum="73331DC101588299" modified="2022-01-19" version="1">MAAVQGAISKRRKFVADGVFYAELNEFFQRELAEEGYSGVEVRVTPTVTDIIIRATHTQEVLGEQGRRIRELTSLIQKRFKFPENSVSLYAAKVQNRGLSAVAQCESLRYKLLNGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRAARAKSMKFTDGFMIHSGQPAKEFIDSATRHVLLRQGVLGIKVKIMRGSDPEGKAGPQKTLPDAVTIIEPKEEQPVLQPMSQDYGAKALAAQQAAEQQRLAEQQATEAQEGAGAEAYAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYG7</accession>
    <name>A0A8G1QYG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UV-damage endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_451165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513860.1">
        <property type="nucleotide sequence ID" value="XM_025660526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYG7"/>
    <dbReference type="GeneID" id="37163928"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000012">
        <property type="entry name" value="Related to UV-endonuclease UVE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290:SF5">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0228">DNA excision</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="525"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH55938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="590" mass="66305" checksum="21ED0551E7B9A22D" modified="2022-01-19" version="1">MATDEVMQNGVVGSPDNEVQDADLKGTLGANELGKGSPMDPESDEDVPVEAEELQDALTRAPPVNSSYLPLPWKGRLGYACLNTYLRYSTPPVFCSRTCRIASILENRHPLSDPTQPAHPTKNRPDRDQPADVARGQAYVEALGLTNARDLVKMLRWNDRYGIKFMRLSSEMFPFASHKEYGYKLAPFASEVLAEAGRVVAELGHRVSVHPGQFTQLGSPKDEVVESSIRDLEYHSEMLQLLKLPPQQDRDAVMILHMGGVFGDKEATLDRFRENYKGLSQDVKNRLVLENDDVSWSVHDLLPICEELNIPLVLDFHHHNIIFDSSQLREGTLDIMSLFDRIKATWTRKGITQKMHYSEPEPSAITNRQRRKHSPRVSTLPPCDPTMDLMIEAKDKEQAVFELMRTFKLPGHELVNDIIPHVRNDENRPHKPPRKTRKNGGFVDLEGLVPPRTVPEEEVGMGGPEGRVYWPPGMEEWLRPKKIVRTKAIQSPRRTPSTKKVAVENGDSVPQEDEPNGSVPATPVSKKRTTNAKKQVSRKRKASPEPTPSASDGEASEIPERPALKRSQSSGVRRSRRAKKVDYTEDVDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ50</accession>
    <name>A0A8G1QZ50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_451438</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513573.1">
        <property type="nucleotide sequence ID" value="XM_025660591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ50"/>
    <dbReference type="GeneID" id="37163993"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000040">
        <property type="entry name" value="Asparagine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="271"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH55651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="574" mass="64919" checksum="F4FB0971618E02CA" modified="2022-01-19" version="1">MASIYIDEDVGRDDSTANGTESAPYKTLLHAFLQHAPTDGNQYLTRKSQTEPTEAGADPASKLEWKPATKSAVKKATNLYEQRKRKAAKEQELAIREKQEAEKRQAILEEAKKVVLTEDTSLPKPTKIRLDVTDPAVVKLGSPESETPGTRVRVVGRVHRLRAQKDVIFLTLTDGYGYLQCVLTGNLCKTYDAMTLTLETSIAIHGEMRAVPPKQHAPNNRELHADFYTIIGRAAGDKEAITTRVAPDADPQTLYDNRHLVLRGETASSVMKVRAATLRAFRQTFEENRMLEVTPPAMVQTQVEGGSTLFGFDYYGENAYLTQSSQLYLETCLPSLGDVFCVCPSFRAEKSLTRRHLSEYTHIEAELDFITFNDLLDHLEHVICRVIDLTLAEQATKALIEKLNPDFKPPSRPFKRMKYSDAIEWLREHDIPNEEGKPHEFGDDIAEAAERKMTDIINQPIFLTHFPAEIKAFYMKKDAEDRRVTESVDVLMPGVGEIVGGSMRMDDWDELMAAYKHEGMDPSPYYWYTDQRKYGTSPHGGYGLGLERFLAWLCARYTVRDCSLYPRFTGRCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ55</accession>
    <name>A0A8G1QZ55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">116 kDa U5 small nuclear ribonucleoprotein component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">U5 snRNP-specific protein, 116 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_450638</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514530.1">
        <property type="nucleotide sequence ID" value="XM_025660423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ55"/>
    <dbReference type="GeneID" id="37163825"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001452">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Translation elongation factor EFG/EF2" evidence="14">
        <location>
            <begin position="724"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="Elongation factor EFG" evidence="13">
        <location>
            <begin position="846"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH56608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="989" mass="109886" checksum="4213035B5E70F30B" modified="2022-01-19" version="1">MDDLYDEFGNYIGEVDGSDEESPRHEDAHPQAFAFEEAFGDGDDDEAHDVDEQQLMDVDEGPSNAVILHEDKQYYPSAQQVYGEDVETLVQEEDAQPLSEPIIAPVQQKKFAIEEAELPPVYYSREFMTDLLSYPDQTRNIALVGHLHHGKTAFMDMLVTQTHDLTGRLENRTGKRKEEQLRYTDVHFLERERGLSIKASPMSLVLQGTKGKSHLFNIIDTPGHVNFVDEVATACRLVDGVVLVVDVVEGVQANTEQIIKHAILEDLPLTLVVNKMDRLILELKIPPNDAYFKLKHVIEEVNTIIENVLPGQGAARRLSPEKGNVAFACASMGWCFTLHSFAKMYSETHPQIEAAAFCLRLWGDIFFNPKSRKFTRKGVEEGSKRTFVQFVLEPIYKLYSHTLSESPEDLKETLSSVGISLKPSQLKTDAKTLLNLVCEQFFGSATGFVDMVLQHVPSPAEGAQKKLDRYYTGPLDSKVAAAMAACDSDGPLVVHVTKLFNSSDGSKFHSFGRIMSGTARPGQQVRVLGEGYTPEDEEDMVVATISDTWIAESCYNIPTSGVPAGNLVLLGGVDNSIVKTATIVPLTLEDDEDAYIFRSVRHITESVFKVAVEPVNPSELPKMLEGLRKVNKSYPLISTKVEESGEHVVLGTGELYMDCVLHDLRRLYSEMEIKVSDPVTRFCETVVETSAIMCYSITPNKKNKITMIAEPLDDGIAEDIESGAVNIKDPIRKVSRFFEERYDWDKLAARSIWAFGPDEMGPNILQDDTLPSQIDKKLLGSVRDSITQGFTWGTREGPLCEEPIRNAKFRLTDVSLADQAIYRGGGQIIPTARRAIYSSFLMASPRLMEPIYSCTMTGPADAVASVYTVLSRRRGHVLSDGPIAGTPLYSVRGLIPVIDSFGFETDLRIHTQGQAAVSLVFDKWSVVPGDPLDRDVKLKPLEMAPAMATARDFVLKTRRRKGLAEDVTVSKFLEPELWKGLKESGVLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZI2</accession>
    <name>A0A8G1QZI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_450441</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514354.1">
        <property type="nucleotide sequence ID" value="XM_025660377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZI2"/>
    <dbReference type="GeneID" id="37163779"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000190">
        <property type="entry name" value="COP9 signalosome complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="194"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH56432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="416" mass="45658" checksum="B147915A6F71AD46" modified="2022-01-19" version="1">MASQKITSALAEIESSANPQNKLQLYNNLLSDIVATSTELQISRDLIYFLDSVLSEDISIVAARPILDSFIAVLRKLTQETQISVGQHAITLLQSRSTSVEEQDAQIRELLADAYEAEGQYTDAAKALQGIHIDSSQRLVSDAAKVRLWIRIVRYYLEEDDTTSAEAFLNRIKNLPSKIEDHELKLHFKLSQARILDARRRFLDASQEYFNVSLAAGVDEQDRLQALAAAIRCAVLAPAGPQRSRILATLYKDDRSTSVDEFAILEKMFLDRLLNPEEVAAFAQRLAPHQLAVTADGSTVLDKAVVEHNLVAASKLYENITTDALGAILGLQGSGDFTAGEKAEDYAARMVEQGRLKGSIDQIDGIIYFDGGNATTGQHIRQWDAGVQGLAEDVERVATSITNAFPDFAAGQPTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZK8</accession>
    <name>A0A8G1QZK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_68864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513813.1">
        <property type="nucleotide sequence ID" value="XM_025665594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZK8"/>
    <dbReference type="GeneID" id="37168996"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="102" mass="11633" checksum="52A9310F00E82BE5" modified="2022-01-19" version="1">MQATHPRFCCVVLPRLKPQSAIFSRLKCELPVVYAHEPLFLPCLSDLPWLFVHPDRPRTSNLFPCSPLPHPIFTAFIMSIVISSSVLVTSVSHVYHPRAWCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZP4</accession>
    <name>A0A8G1QZP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="6">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_54578</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="6"/>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514520.1">
        <property type="nucleotide sequence ID" value="XM_025665473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZP4"/>
    <dbReference type="GeneID" id="37168875"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000002">
        <property type="entry name" value="Glucosamine-6-phosphate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="355" mass="39317" checksum="96C70AC08A4723D4" modified="2022-01-19" version="1">MRVIIRETSLEASEYIADYIISRIKSFKPSEDRPFVLGLPTGSSPEIIYKTLVRRHRDGDISFKNVVTFNMDEYVGLPRDHPESYHSFMYKHFFSHVDIPPQNINILDGNAPDLAAECSSFEARIARYGGIELFLGGVGPDGHIAFNEPGSSLSSRTRVKTLAYDTILANSRFFGNDLDLVPRRSLTVGIQTIMDAREVVIVATGAHKALAVEKGLEGGINHMWTLSALQLHPYALIVCDRDATLELKVKTVRYFESIEQSGTDARTQGPPLVYRPRTYVPAPVGVGKLQPSHIPPQKAPKDLRINTELNASVEDEELTPDSMSSRMVDSAIGGLDSTLKGDMFFDHMGSRVASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZQ1</accession>
    <name>A0A8G1QZQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_514109</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515308.1">
        <property type="nucleotide sequence ID" value="XM_025664742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZQ1"/>
    <dbReference type="GeneID" id="37168144"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="658"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="705"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="733"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH57386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="790" mass="89709" checksum="BD2C5C53C6F8757B" modified="2022-01-19" version="1">MADYREPISLSSQSDKEKAKATGTKIDESDLQSLLDQLRQIVAENELDVNFPVQIIAQAREILDADTKHIDLSQLQEVMSDIEKHRDLIENDSPYPEVRAVVDPTDDPEISANTFRAWFLGMIATIVFTGVNQFFTLRYPTIVIYSIVAQLLLNPGPFNQKEHMLITVMSNVSFGGTNGTAYVTYIFQVLKAKSFYNLTSLYDQAGFQILVTLSTQLLGYGCAGVVRRFLVYPPSMIYPKCLSTIALNKALHSDEGRERVHGWKISRYRFFMYCFIGMFFYYWFPGYIFQALSYFNWINWIAPDNVKLAIICGTITGLGLNPLPTFDWNIIYALYDPIIYPFYALANIGIGTILGAFCVIAPVYFSNVWKTAYFPIISNDVFDDTGNTYNVTRVLNSKGEFDLEGYEGYSQPYLTAGYSVMFFFFFAMYLATIVHVALYNRREIMKGFRALWKWASAREEHEDVHNRLMKQYKEVPEWWYLVVLAVAFVFGCIGVAKYDTGMPIWGIVFAIILCLVLQIPYGMVYAITNSEVTNNVIAEFIGGYAITGKPVANLLFKAFGYIACAQSIQFVADLKLGHYMKIAPRVMFAAQLAATIVGAFVSLGVNVWALANIEDVCSTTQPDKFTCASARDFYTSSVIWGAIGPRRLFGTGQIYNPLLYGFLVGALLPIPFYFITKWRPRSILRYVYIPLVFYGICDISPYNVTYAWCPMVVGFIFNYWIKRRWQAWWEKYAYVFTTAMSCGVAISAIIIFFAVEYKEVDLNWWGNEVSYAGCDNDGCTLLAIPEGGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R041</accession>
    <name>A0A8G1R041_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_372079</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515533.1">
        <property type="nucleotide sequence ID" value="XM_025656023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R041"/>
    <dbReference type="GeneID" id="37159425"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF9">
        <property type="entry name" value="DICARBOXYLIC AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="20"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="559"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH57611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="594" mass="66530" checksum="922B67A68E34032F" modified="2022-01-19" version="1">MTNHVDTSEKLKQELFGFQIFFITLSVVIGSGIFTNNGMALAIAGPMGLILAVLIISIVVLAVNECIAELAQQFPVYNSIVEYVRTFVDEDFGWVIGLAYWYAYAATFASQTSMAATLLEYWGLATAWRVLICYVMVPVILFLLNMTGVFWYGVVETIGGFLKLVMIVAISIYLYTIADDVSSPSFEHGQGFSSNGQAQCYAIPLTAYAFQGIEVYAMTAFEARDGHALRWPARWTAYVAVVVYIMCTLGEVINVKWDDSALPKLHDGVSNSTLSATSNPGSSSSMIVIAALNTNNRSMAGFLNGCLLFSVFSAANTSLYVASRTLWGMAKHFPRSSTKELWVKKKLAILSEGTKVPVVFLLVSLLAFCWVPFLQLVDSSAVQQVVQVISISSSTAIMIVWAAICLAFIRYYYWFVLKKCEPRLRYHDRPEYIRLDEKYIAKGSLRILQPLQAWIGLIGCITIFAFSSATWWSETATVTEVAMAYGPHMVLFLIFIISKAFSKNKGWVKLTNDEWVLRNALDRLWIRKIDHHEESASERLKSVMKSLFSKLWERFRDRQNSQQADGDVHHRSEGSTSAETNRQELLTISNDQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R062</accession>
    <name>A0A8G1R062_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_104726</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512442.1">
        <property type="nucleotide sequence ID" value="XM_025653805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R062"/>
    <dbReference type="GeneID" id="37157207"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="73"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="437"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH54520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="53804" checksum="33BE8E4C1482F187" modified="2022-01-19" version="1">MPSAVQAVDFSWSSTAPGSVLNFVPCYQDYQCARLEVPLDWSASATEITTATLAVIKLPAQVDPADERYGGSIIVNPGGPGGSGVQEILDRGKEIQRIVNSSDDTQHSRYFDIVSFDPRGVGNTLPPLTCFPDLLSTYLWSEAVQAHGLVGSSDHAADHLWARMQALATSCTDPHKDGADIGPYMNTWSTAHDLHHIAQLLQPDPHADAKLQYWGYSYGTLLGVTYATLFSNQVHRMVLDGVVDAVSWYSGDLSTSFRDADHILDSFFRYCHQAGQPRCAFASPSANGEDDENAISDLQQRFKNILSDLKASPVWTTHPNPDIITYSDVRRLLKLALYAPVDLFPTLATILADLEQRNTTSMAGWKSMLREEMQPTHCLDPECQSHAPCREACQYSYRVEVTAGTVCLDLNQKLLNTTREEYWDEYLRPSIESSHWMGDTFADFLMPCARWNGRGPGDFKGPTGAEDTSIPILFVSNTLDPVTPLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0M0</accession>
    <name>A0A8G1R0M0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_438472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515265.1">
        <property type="nucleotide sequence ID" value="XM_025658672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0M0"/>
    <dbReference type="GeneID" id="37162074"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH57343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="68393" checksum="7F1A58C6AC2CDF63" modified="2022-01-19" version="1">MGTLDGIDDLAELMVEGSPQNRQILQNSSNILRMASHIVGAAGLDLSSITSDVPFSHTFKGQSNSPKVLEAYENTVGRWDPDPEYHRAAEEGNLFLDPESSCIENHLAYPSARMSDDTVSSDTRDRILAMILHTCEPANMIKVVSAFPAANVLDRLLHRFYATHTTDDDSWIHIPTLRSSEMPTELLGACITSAAMRSSSAAVRRFGTALHGVLHPYLFQIQIQALALYVQTGLWSGNKRRMEIAAAIVGSAVTMLRSGRRYRASTYTSVIPDPADTDDVLESKWHHWVEQESWKRLVFHMHIHCSQESLVTGSRTPVSYAELCLSFPQSGKLWAAKTAAQWLRTYIQMQSFEKTFQQAGLREYLANPSLLQTISPLYDSNLARSIVLHAVGSMVKDHLQSKGLLLPGILDTPGDFLLADESFQNRVAQLLNSIRILHDDSQPGDHHSSQLTAELISMHSLTPFEQIEIIAGREGPEEAEAVLPLLERWCQSSQARKAVWHASQFIRYLHHLNAQSFTEFFAVGAYQASLCLFIYGTMAQMPSSSNLSSGLGSGGNFQIDGPDSPVIQRWIILGSGTPMLGSVTSASTFYGGMPLGATRSILLRVRDLLNWVIENVLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0Y9</accession>
    <name>A0A8G1R0Y9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent rRNA helicase RRP3</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP-dependent rRNA helicase rrp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BO85DRAFT_440842</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 24">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with the SSU processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512847.1">
        <property type="nucleotide sequence ID" value="XM_025658788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0Y9"/>
    <dbReference type="GeneID" id="37162190"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000681">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="83"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="266"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="443"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RAH54925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="471" mass="51844" checksum="3A143DCD3A36D2A7" modified="2022-01-19" version="1">MPGVKKRKVAREAPAPAPAPAQESDVESSTPEQSPEPEAQEQVQEQEEGQTKTFKELGIIEQLCEACETMGYKAPTPIQRESIPLALQGRDLIGLAETGSGKTAAFALPILQALMEKPQPFFGLILAPTRELAYQISKSFESLGASLGVRSCVIVGGMDMVSQSISLGKKPHIIVATPGRLLDHLENTKGFSLRNLKYLVMDEADRLLDMDFGPLLDKILKVLPRERRTFLFSATMSSKVESLQRASLSNPLRVSVSTSKYQTVSTLLQSYLFIPQKHKDLYLVYLLNEFAGQSTIIFTRTVNETQRLAFLLRALGFGAIPLHGQLSQSARLGALGKFRARSRNILVATDVAARGLDIPSVDVVLNFDLPGDSPSYVHRVGRTARAGKSGLAISFVAQYDVEVWLRIEGALGKKLKEYDCPKDEVMVLGENVAEAQRQAIMDMKDYNEKKGSRGKKFGGKRSRDEMDQEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R143</accession>
    <name>A0A8G1R143_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sin3 binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_89573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512922.1">
        <property type="nucleotide sequence ID" value="XM_025665768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R143"/>
    <dbReference type="GeneID" id="37169170"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000432">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018818">
        <property type="entry name" value="Stb3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28164">
        <property type="entry name" value="PROTEIN STB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28164:SF1">
        <property type="entry name" value="PROTEIN STB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10330">
        <property type="entry name" value="Stb3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="40681" checksum="C7D5F193DAE31319" modified="2022-01-19" version="1">MAFMNTTSSIAMALAGKTASVDIPKPRSGFTPGGRDSARPGHPAMLPTPPNSISPTLPPQGFRRQGANHPGYSPLSSSHVESDVELGDAADHTNNSNEARPSAHDLDSTGAITPGMLAKCHLPEIMLQHGPLAIRHLMGYLTTSVPGFSGIPPAKARRLVVAALEGRGSEDKSGGRDGDVIFEKVGWGRWDARRRGEPLRDAQHLNVSPPASISNSFPQRGMQIPTKRGSVQPYGSSVTGDSAVFSYSEMDYGGHDVSMLEHEADKMSLDGNEREYCSSSEAPDDEMQDEDWGEEDITDEEDWAQIGADALRARSLNASGGFVNGTHNSPQLRGGGPAASSLAKSAPRRLPVQQHGFTLPEGVMGDREERAAVEALLRLGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R147</accession>
    <name>A0A8G1R147_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_307534</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515550.1">
        <property type="nucleotide sequence ID" value="XM_025655388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R147"/>
    <dbReference type="GeneID" id="37158790"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000136">
        <property type="entry name" value="Sensor histidine kinase/response regulator Fos-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="202"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="277"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="343"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="598"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH57628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="717" mass="80430" checksum="EABF0518431B1C58" modified="2022-01-19" version="1">MDLNKRLFHLDIENKPQAQPVNFSMVTTPPDDEDDDEVNHLKLKVESKQSPHEHDKPHPREKNMPDTDVQQSPAALGRIYRYTPIPSVILDPSLHVVEVSNSHVAFAGLSRELLLGRFICDVCPRILPAIDIAILFGALRAAITTQDVQSIDKICIDDASACYTLRITPIFENSNLLYIVLEALDISKRQIKSVSKSHGSYSNETYKVLLDTVKDYAIFMLDTHGHIVTWNTGAALLKGYSAKEIIGLHFSTFYSLEDRMADKPGKELEVCLREGKVEDEGWRYRKDGSRFWANVLITPMYALGRHIGFTKVTRDLTERNAAEARMIAAFEESSRLKTDFLANMSHEIRTPMNGMLLALTSLMATDMNEQQREYSSIIEDSTNVLLQVINDVLDYSKLSSGSFTLHPDTFSVDSITNAVVRNCKGALKPGVKLTSFIPPNFPSQVEGDPLRYRQVLQNLISNAVKFTEEGYVKINTTFSEDAEDPNVYNIRTEVADTGVGVPEDAIGSLFTPFTRFAESGSKRYQGTGLGLSICKSLAELMDGSVGYRPNPERKGSVFWVTAKMRRVSVTPPARTTGTPVEDVGDIERKIHDIAPHKHVLLVEDNLVNQMMMLKLLQNMGFARIDTAWDGAEAVRLVKQQPLSYNTILMDIGMPVLDGVQATRQIRQMELEMPIIALTGNVMPGDIEHYMKQGMSDHIGKPIHQKQLMRLLWKWMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1B6</accession>
    <name>A0A8G1R1B6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_520419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515655.1">
        <property type="nucleotide sequence ID" value="XM_025665138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1B6"/>
    <dbReference type="GeneID" id="37168540"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="305" mass="35696" checksum="42EDE5652DA89450" modified="2022-01-19" version="1">MTFLTQHASIMLKRHTYQIPNTLSRTLPFLFLPLIWHGHRSSLYVTSPQPYMKKRTLQFPSRLLSSSLPRLSLGTQDSKRTPWWPIRWNDADLIEKNMHDLGFQTWGIVIYRCTYKSDSDWEEFLSRFLHKVRTSLESYDGLDLLDSFRPTVMDDKTQFDGVTPNIVRDHFNRWSATACEAEQGVPLTDYRWHSTARYGLCIMVDDESLRSVLEIPLESLDQWNNSGFVILVNGRYEVDRASIEESDEKIEDDDYEPLHGCTYEDVGWMKVCYDMAQVYACAHLGASSWWEEDYRRPPEIALGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1E4</accession>
    <name>A0A8G1R1E4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_301662</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515390.1">
        <property type="nucleotide sequence ID" value="XM_025655350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1E4"/>
    <dbReference type="GeneID" id="37158752"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034980310" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH57468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="235" mass="24212" checksum="66F519B1FBCED767" modified="2022-01-19" version="1">MHFLNIVVSMMAFAITALAITITQPKNGDQVDFSKPYTIKWTTVASDPTDFDLILVNMNSQPTVSKKIANVKTSDSKYTVDKVIGIPVAEGYQLNAESNTTHNTGILSQSQQFNVTKVGKAETSKENSILSSSPPSPSQPSSSSPSSSPSPCIRPHTSTIITKTTSRPCINHQTTSPSSTAPSASTTPASATTSATQTAAASTSSSAGSAAYTGTLPGSAAVIGALAMGVIAEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1S9</accession>
    <name>A0A8G1R1S9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_520388</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515600.1">
        <property type="nucleotide sequence ID" value="XM_025665133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1S9"/>
    <dbReference type="GeneID" id="37168535"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH57678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="353" mass="39747" checksum="C317FFCB48AFC488" modified="2022-01-19" version="1">MPFAQLVIGPPGAGKSTYCNGMHQFLGAIGRKCSIVNLDPANDKTSYPCALDVRDLVTLEEIMSEDQLGPNGGILYALEELEENFDWLEEGLKDLGEDYVLFDCPGQVELFTHHSSLRNIFFKLQKMGYRLIVIHLIDSYNLTLPSMYISALLLSLRAMLQMDLPHLNVLTKIDNLSNYSQLPFNLDYYTEVQDLSYLLPHLEAESSRLSHEKFGPLNNAIIDLVEEFGLVSFETLAVEDKKSMMNLLHVIDRASGYVFGPAEGANDSIWQVAVREGLGQMDIRDVQERWLDAKDTYDEHELKQLEEEAKANEKAAEEASAKKPNMNFDDDDEYDDLGRGSIPDGGVKVIRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1T0</accession>
    <name>A0A8G1R1T0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_479152</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514157.1">
        <property type="nucleotide sequence ID" value="XM_025662934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1T0"/>
    <dbReference type="GeneID" id="37166336"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="28"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH56235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="381" mass="43040" checksum="2F589A796033DB85" modified="2022-01-19" version="1">MTPLNHWGITLVVVPIVASVVTTLFFILRLYSRRLVRQKLDLGDLLMGIGLVFSYGLTLCTVISALNGVGHDFWSLSRPTRGTVALLFWCSTKIWVLGHVFVKISYLVLLRKLFGAITYWRKLTTALIVFTLAWGIASLLVSIFQCWPVRYFWIKHIDGSCMHGRNAFYIVAGSIALAENFVLVLVPLIVVWGMKLTPRQKVELSLLFGFGGLVCAVGFLRMITFKRYVTADATKNGYLQSIWSIVELDLGIICTSVILMRPIFHRVTKTFKIKCCAMRGQTSNSSDSSKRAQMMRSLSWPRPLSFAGTGSVDEWSQVRASAYSTRVHGSVDGTPGLAGNRDVMVEVSIDREKRAKEEMEEMEEMEEMEEMEEMEEMEEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1U9</accession>
    <name>A0A8G1R1U9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cutinase</fullName>
            <ecNumber evidence="3">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_514511</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3"/>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515630.1">
        <property type="nucleotide sequence ID" value="XM_025664764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1U9"/>
    <dbReference type="SMR" id="A0A8G1R1U9"/>
    <dbReference type="GeneID" id="37168166"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000235">
        <property type="entry name" value="Cutinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043579">
        <property type="entry name" value="CUTINASE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00931">
        <property type="entry name" value="CUTINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034570736" description="cutinase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="37"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="177"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH57708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="262" mass="27480" checksum="C9D546367A847BE6" modified="2022-01-19" version="1">MKLLSVLVGLAGLAAASPMGLAERQLSDGNELREGSCKPIIFIFARASTEPGLLGISTGPAVCNDLKMAKAGQVLCQGVGPAYTADLMSNALPDNTSPAAISEAESLFKLAASKCPNSQILAGGYSQGTAVMDDSIKQLSDDVKDKIKGVVLFGYTRNAQEGGQIGNFPKDKVKIYCAMGDMVCDGTLIVTAAHFTYVMNTGEASQWLESKLSDTTTSSSAGVDSEHLLGYNEPTGDFWPCLVSVSVVEISCRVTSHIKEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1W8</accession>
    <name>A0A8G1R1W8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM complex subunit LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_487565</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515660.1">
        <property type="nucleotide sequence ID" value="XM_025663467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1W8"/>
    <dbReference type="GeneID" id="37166869"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000042">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH57738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="98" mass="11264" checksum="55BFF2812830AA97" modified="2022-01-19" version="1">MLFFSFFKTLTNQTVTIELKNDIRIRGTLKSVDQYLNIKLDDVDVLDLDKYPHLSSVKNMFIRGSVVRYVMLPRSEVDIGLLEDATRREAANQAGKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R285</accession>
    <name>A0A8G1R285_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_298587</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516150.1">
        <property type="nucleotide sequence ID" value="XM_025655326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R285"/>
    <dbReference type="GeneID" id="37158728"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000013">
        <property type="entry name" value="C6 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH58228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="307" mass="34307" checksum="D456B374E99E175B" modified="2022-01-19" version="1">MRTMTARQSSPTSDHSHSDGNVRKRVCKACDRCRLKKSKCDGSNPCGRCRTDNAICVFGERKKAHDKVYPKGYVEMLEQQQTWLVNGLQEMYRRALEGEGWPGEPLKCEPNGHPLTHDLLTRLGALDQTKGERFEENTEAMQQDLWRQNSGHMQRQESSDGSSESAQSPIMPSRFSDPFARQLSSTQSSFSTPSQTQGPTIKSEPQMAPTNPAFVAPMTMQGVVNPLALQTPQQWPNNNFGAFDDMDLIGASDYTNLSFDDQVPSPMFNRQLPMSCMLSSSSYMDTKGDYEDINQFLNANAPEIAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2G5</accession>
    <name>A0A8G1R2G5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_487515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516733.1">
        <property type="nucleotide sequence ID" value="XM_025663460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2G5"/>
    <dbReference type="GeneID" id="37166862"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="122"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH58811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="283" mass="31255" checksum="A7FBF4CB02173ACB" modified="2022-01-19" version="1">MIALSSAVVIARFSLIFWKLRSLQVEDGCILLSWACFLAMSIAYIIVTPVMYKIDAYTDGKIGPWATMLSDALFMIKVFFANTMLLWGSLWSVKLYFLFLYRRLLQDLPGECSTHRDAVAEIASLYYSFAVDAISDIMIMVLPLRLVVSLHLPLGQKISVAAVFALGTICVIMAVVRVIQIGTRANNDSTPSSSWLAFWGMIEAGIAVIVGCLPAFAIIYRRTKNPQRYRSSYVGMSSSVYVPQEDVPLSELATRGEDSGTGETGLKAFNTTPELPMELSGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2J7</accession>
    <name>A0A8G1R2J7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_514040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515264.1">
        <property type="nucleotide sequence ID" value="XM_025664731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2J7"/>
    <dbReference type="GeneID" id="37168133"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF17">
        <property type="entry name" value="O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="45"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="157"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH57342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="375" mass="42093" checksum="0561F3D832346A32" modified="2022-01-19" version="1">MTRPTEHSNVVLETLNSIGAHIFATDGDRSKALLAAYALPALWASLKVVKDLQLFEKWHEQGDAVQSSDELAALVHCNPDLFGRILRHLAVNHVLAEPTAGTFKPTSFSLALLQPVFGEWINYLYDLGIPVFHSAPEFLQKTNYRNPTDPKDGIFQYAKNYQGDLFEYFTSHPREGTSFNHAMGGVMAHQASWLDIIPGEHFIDGSNPDLPLVVDVGGNIGHDIEKFRQVYPETAHRLYLQDRAAVVELAKCPDPVNKMVHNFFQPQPITKSRVYYLHGILHDWSDEPAQKILLMLRDALMPGYSKLLVHDHVVPEKDAHPHATSYDLTMMAMVAGLERTETQWRTLLSSAGYRVVKVWRSPLAAQAVIEAEVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2R0</accession>
    <name>A0A8G1R2R0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_477053</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516266.1">
        <property type="nucleotide sequence ID" value="XM_025662812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2R0"/>
    <dbReference type="GeneID" id="37166214"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21223">
        <property type="entry name" value="CH_ASPM_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="627"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="58"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH58344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="980" mass="108792" checksum="E76C188DE291F5E9" modified="2022-01-19" version="1">MPGFLYEATTPCPSRTNTSFFSRGSNRSSSDSMWEDSLGNWDDTANIEFTTEIKQSVLTGARPRRRTKTSTSFAIHEDHGENPTQPAYKPKRDSSIAAPTTSRKTSLLAQPAQRFRPKISFGPSPDTQSRQDGLTHQSPSKRTDTEKNNALLMRINGADGQEKARNSLKTDVRRNTVYIPADDGTVASVFMGLFSPPKSDNLDKCINGDTQVNSLESQIAKKRQAKRSFASSAQRAPLKPSSKVMQESCIHHDIAGKNGGKENVPPGTVIAEGKKIHQALKAKEDSGNRLNSPLMAARRAGATNASAKPTSKPLSTKTSNTQQRSNVLSNSQNTTKARQRKSEHNSTMKPSLTSDYNRNASTRTSNLSTSPKPSKTSIVSKSTTSRNNTKPIAKDCPVVSDNITNPALYEENWLSHQEVAITQLVNEMFQCTYEEPEIDNHAMLRHELLTLYQGASFAHLHKRLQASSLYGALSIPKDVLTRSSRLHNDLGLKRKFLDIWIKTYDLRALRAAAEAIIGRKIPTSKLVHGDDASDNDRAMKRKLEGFLDAFLLRNQDIDPQEKIAAGENGGAAGQAYRRTVLRSMMMVVLLDKARMGHGTAVPRRLFLSSSPVKSSSAVLQALGRFLLPSCGDIIKALSHLGCELMYEQHPLEEHDYRVDNLAVDLRDGVRLTRIVELLFYPSTSSGEVSNGSLPLSSHLKFPCRSRTVKLFNIQIALDALACGQETRKLAKDIRAEDIVDGHREKTIALLWKLVSTWSLAGLVDWGDVKKEIQRLRQKVTFQAGEDGMPLSGDDESDEPTLLLKQWASTLAHLKGVPVDNLSTSFSDGKVYESIVDEYDGYLVEHAEDHSRTASLESRLRALGCSAEFAKLVSPSSKSHIVDSDFTIGALAFLCSRLLPATKRARAATVIQTAWRRILTRRDDERRVIARDIARQCAAVVQTQHRILWAKEVIVRWWRLTRSQQHGRVVAAYAYEDNQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2V1</accession>
    <name>A0A8G1R2V1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_449260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516079.1">
        <property type="nucleotide sequence ID" value="XM_025660125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2V1"/>
    <dbReference type="GeneID" id="37163527"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH58157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="336" mass="38469" checksum="D482BB343B2CBB1E" modified="2022-01-19" version="1">MRSLLSVLSRTGTRTTPLRPASSILRTALNRTGTAAGPDSLCTRCLRRTNNTTQLRFYNNNQFNDDQRWLSVVDAPSQVVRTGRKHGPGLIILALIPIISFALGTWQIQRLEWKTNLIAKFEDRLIKPPLPLPPRIDPSAISEFDYRRVVATGTLRHDQEMLVGPRMREGQDGFFVVTPLEREGGSTVLVNRGWISRKMKEQRDRLRQGEGRALPEGKVVVEGLLREPWKKNMFTPDNVPAEGKFYFPDIEQMAELTGSQPVWIEETMVPDMVEAMDREAKGIPIGRAAEVNLKNNHSQYIFTWYGLSLATSIMLWMIIRKRPNEATRRVRHNRNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3J7</accession>
    <name>A0A8G1R3J7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pfs, NACHT and ankyrin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_458930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516731.1">
        <property type="nucleotide sequence ID" value="XM_025661619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3J7"/>
    <dbReference type="GeneID" id="37165021"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="414" mass="45707" checksum="0C07A26AD7804A02" modified="2022-01-19" version="1">MSFPHPNTSYTLAWICALPEEYDVAIAILDEIHGLPQNQPLEDKNAYLLGRIGAHNVVMVCLPAGRMGTTAAAIVAENLCQTFRSVKYGFLVGIGGGVPGSGRDIRLGDVVVSVPGGGYGGVVQYDLADESVYQGPLNSPPEKLLSYVTLLSILMRSPRVAGNCFREQLELLGEEFEYPVRLEDRLFCSGKKRKDTLPVVHLGTIASGNTVVGDGVTRDTINHRFGNSILCFEMEAAGVMNTLPCLVVRGISDYADSRKNDEWRPRAIAAACSYAKALILQIPPEEVPQQEIYVHVTGPIKDLRDELGQIKAALYGLWSLQRDNAYTESHNDHRLTTVWSRSVSITASLTSRLAFPYYGLMQASQYVSYRISSFVDSMKRYICSKLLGYPTRDAKAGPRWGWHLIAEPHMWMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3V2</accession>
    <name>A0A8G1R3V2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_459323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516078.1">
        <property type="nucleotide sequence ID" value="XM_025661644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3V2"/>
    <dbReference type="GeneID" id="37165046"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23187">
        <property type="entry name" value="UBX7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="UBX" evidence="7">
        <location>
            <begin position="268"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="400"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="464" mass="49876" checksum="2D1352A1AA8EA156" modified="2022-01-19" version="1">MFYSGSLQEGIAAAVAESKAVVCFVRDDEQTSTEWEESYFTFDEELSQLLQSRAVLLRFTKGSQEAGFLASFCPIVKFPTVVVIKNGMMCDYLVPDISKEDFRDRLLVKLDESRAPVQQNVGNAGAAGGETTSAPVASDAPATVSPPAPEPVSSAPVSAPAPAAESAPTPAPSQPAPQPSTTEPEQPRDAAVREGKRRVDDARAEQQRPSPTKKLQQQKKQEPAPKPPPRPVTQESKPKPKPTPKEKPSSSVTPKEPATQPAERRPPSPPKQYRLQVRLFDGSSVRSSFTPTQTIRNDVRPWLDSQMEERSPYNLKHILTPLPNRTLTIADEEQTLAELGLGSSANLVMVPIQSYTEAYSGAGASLPVRAVSSAYGLVSSAVGTATGLVGSFFGYGTTQASGSEAAPTASTASSGSNDAGRRRVNASRGPIIRTLRDAQNEGDDRQFYNGNQLNFQPRNDGDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3Z4</accession>
    <name>A0A8G1R3Z4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_439527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514332.1">
        <property type="nucleotide sequence ID" value="XM_025658718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3Z4"/>
    <dbReference type="GeneID" id="37162120"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034014102" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15635" checksum="87F0063C5D58599A" modified="2022-01-19" version="1">MGQITGLVVLVCRFRHILCLVAACRSEVGSANRRYPVLLTPFGYGEKVVKWSGYEVNTFCFVRINSRGGSDRLHYHDDGGGDDDDGDVSVANMNVKIIVCKAKLIRASQAMMWTPVIGLPVCTVLCWSEGVAVNKVPVLLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R449</accession>
    <name>A0A8G1R449_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_518952</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517046.1">
        <property type="nucleotide sequence ID" value="XM_025665007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R449"/>
    <dbReference type="GeneID" id="37168409"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF15">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="40"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="476"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH59124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="662" mass="73330" checksum="A93485472016D7C7" modified="2022-01-19" version="1">MPVFTEFAASSRELRVLPSFAPPLPRLSPNDPRDGVPERYEVVVVGAGPAGLMLNLLLARYGLNDTSLLCIDAKPGTLKSGQADGLQPRTLEVLKTLGLADEILTDGCHMEEVAFWNPSPNKDEIIERTAIVPDVAVPARFQHEVTIHQGRIERILETDLLRYSKRGVQRDTKLLDVTIDEDGDSEFPVVAEIETAGQRRTVRSKYLVGADGAHSVVRRCMGLKLVGESLDHIWGVVDLVVDTDFPDIRRRCAIHAPATSVMVIPRERIATGDYLTRLYVQVPDEATPDEDQKSVNESTPKDARARRSQVTLDGIFHAAAEAFKPYYIRPKTDGAVDWWAAYQIGQRVSDQFTVKDSKGANRVFIVGDACHTHSPKAGQGMNVSMMDSYNLAWKLAYAINGLTPASASPGKPDAVLDTYHTERHTIAQELIEFDRAFSSMFSGKIGAAEDGADGLTHEQFLEVFSTGNGFTSGCGIEYPESPIVQKVQGGKKNPIEGTDYLSGILRPGRRLLNVKYRRHADGNRRNLHDDFLSTGRFRILCLTSYDLLYPKGVSAQTLRTIGSAVLPRFPASVIEQVVIHPRLSREFTWRDLPAELKRHSEMSFYSGYEMDDVYKIYGVDAARGALAVVRPDGYVGTVAALDDVKRVEQYLERCLRTVQTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4D0</accession>
    <name>A0A8G1R4D0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_460528</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514527.1">
        <property type="nucleotide sequence ID" value="XM_025661723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4D0"/>
    <dbReference type="GeneID" id="37165125"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="262"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="460"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="462"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH56605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="513" mass="57343" checksum="69A544AB7881334A" modified="2022-01-19" version="1">MSCHTCFRAPASRTRFFCPTCARSQLYQLRVENARVLLEKQSIAEHIQARVTPETTQAEWSGEIKETAIAYQNGLSAKRSLQMIVKGEAESCERLRLLGDQLENLTAEIKDKRLEISQRRLALARRHSDSESAQYQLGEREAAILANIQNNTKRTDHLWHSLHSKTAEARIFLCREAANLYGLQRKTRSKEGLSQEVYTMGVTPAYISTSLFNVAHLLVLVSHYLSLRLPAEITLPHKDHPIPTICAPSASYLSRDPNSVTYSLRHPPSVPPETRTTSPRPSRPRPLSIDRALPKLAREDPGTYALFLEGVTLLAWNVSWLCRTQGINITSESWEEVCNVGKNLWQLLVAPPAQPSTLSRAFAGRDIQAKMRVSKDSPRTTIQRTMSFPMLGHYSHGTAHSFLGAVEGAEFMRTWRLPTPTKIVDKLKSTLLGEMASAEWELLEGDWDDASQEPRESMLIQHPSTDSTSPERQGNTNSGNSVNDTVAGASNLSGPRGPTRMKGTSGWTKLRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4I8</accession>
    <name>A0A8G1R4I8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ser/Thr protein phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_369440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516964.1">
        <property type="nucleotide sequence ID" value="XM_025655920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4I8"/>
    <dbReference type="GeneID" id="37159322"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014485">
        <property type="entry name" value="Pesterase_C1039"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF22">
        <property type="entry name" value="ADL392WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017316">
        <property type="entry name" value="Pesterase_C1039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034172747" evidence="2">
        <location>
            <begin position="20"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="57"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="4">
        <location>
            <begin position="417"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH59042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="660" mass="73756" checksum="1CE0167E3B7DF9B3" modified="2022-01-19" version="1">MAFSALAWTAAIALPAVFAQDREPDRSKSPKIAPRMQHDSHNTTHWPTRPLPWGEINFIHTTDTHGWLEGHANEVNYGADWGDFVSFVTHMRDKADEQNVDLLVVDTGDIVTGNGLSDVSTPEGQLSNPIFRYLHYDLLTIGNNDLYDPNVTHQIENDLVSFYEDRYLTSNVLVEEDGKNKSIGEKYKYITTNHGLRIMAFGFTLQDFNSPPGLYVQGEEEITNEEWFNDAMNKTVDLYLLIGHADIGQSCKIKTKYHGDQNPLICMKDWFRENKPEIPLQVLGGHTHVRNFTCYDSGSSGLESGRYSDTVGWLALSGVAPSDTWNGSKTLTDVPMPTRTCTPHGSTSSSTTDKTVRLDRRYLDFNRQTFAYHALGATGPDVPASFDTPTGQYLTNDIEGTRSQYKLTTELGCAPQSYYIAASPYNCPDNIYTLVRSALNATVHGNNSDSARLIIFNTYGIRYDLYQGPFTVGDAFTVSSYADIFYYIADVPYDDVTKKLQGELNARKGSDPDYEEPKKDCGSNSVRLSTGRYAGASQQSVLTSRASDPDNLNPGHVTKDDFGDCSVNPEDCGDDTLHIPRLENEPHPYFMQVKGNIDENETKTVDVVFTIDIQKSIIDLLGLKDPVVKPYMDESFTTRDFLQVYAKTVWSEKPTCEIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5D3</accession>
    <name>A0A8G1R5D3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO85DRAFT_393643</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517721.1">
        <property type="nucleotide sequence ID" value="XM_025656890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5D3"/>
    <dbReference type="GeneID" id="37160292"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RAH59799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="468" mass="51380" checksum="188462D7760880D6" modified="2022-01-19" version="1">MAAANSSSLSRQETWRLFALVGACVGILLNTFQGDGAPLVASLAFSGIAFAVTFSMIRWLVPVFLKAGLKGRDMAKPRRPEIPETMGAVCAIVYLLALIFFIPFAFYKDIVAATSGGGNRDVVIEVEHVETGRMLHRFPHGKLASYLSGLLSLQCIVILGIGDDLLDIRWRHKVLIPAFGAIPMLIVYFVDFGVTQVVVPVPLQPYLGSTIDLGWLYYAYMAAVAIFCPNSINMLAGINGVEVAQSLVIAVLLIANDVLYLAPITPYPHPATDSHLFSLYFLLPFVGVSAALLCHNWYPSKVFVGDTYCYFAGMVFAVVGILGHFSKTLLLLFIPQIFNFLYSTPQLFNLIPCPRHRLPKFNSVTGLLDASVTEWTVPPSPLVATALNLLHTLRLVRVTKNEQGQIVESTNLTILNLWLVWAGPMKENQLAWSMVAVQTFCGLAGLFVRHRLALLVFREDNLAFGSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R668</accession>
    <name>A0A8G1R668_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_259362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="555"/>
        </location>
    </feature>
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        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
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        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="555" mass="59962" checksum="F95F2A12B86F4A7C" modified="2022-01-19" version="1">MDAQYPFASRDDIWRVFEELKELHATQFEQAERIARLERRRDEDAKLRSVWGPLSPFPSSVGGTIPTEPVFHTPADAFKGFDQGHHHGAVSTMGLDNEEEPRRGTSRANSVRFDESAIHGYYGQANRSSSELPLRTGSGLGSHPLTERSLSHRSDGRQSSSGHSHHSARTNSLGLETTSRMMSSVGGSPLIPPPGLFLLGPVPCIIRCWLTTTFSNDSLLYAAVCSGSYTSSLGYPMVQTLGLADQVVYEGEMQYIKLPIYLPEASVHQASSRSSSPVPQVPTLTVRFLVREVEPGDTAIQIVLGSDVLRSHNADVLFSQDKIIMVDDERNKVSIPLVRPEDDSVFKSLSTMSDATRIGRKARSVHEDIQADTNGHATFGVIGRPPSLSRRGTSTSASARESLEGSEESRKARPETQELPTDTDTQKEPKSATEVDAQASGPARVEAAGVWGSWKRESKPDPNPSATGKATRGRTMKVLRPTKSSTRVPTATTVPSSSGTDYAATSGPSQPASTRASPDGTRTSKQWPSNPVGGASAFGWLNTTQPPGRTAMTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R723</accession>
    <name>A0A8G1R723_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_485536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518314.1">
        <property type="nucleotide sequence ID" value="XM_025663333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R723"/>
    <dbReference type="GeneID" id="37166735"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034292533" evidence="1">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="80" mass="8631" checksum="DEFF8FBF0F90CD89" modified="2022-01-19" version="1">MRPSSIITFLSLAVLPVALASPVGSNQDSAIAKRCCILCDNPYARCGANDKREAVQTEEEVFHGQEKRCCVNCDVGRCGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R735</accession>
    <name>A0A8G1R735_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aryl-alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_476169</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517396.1">
        <property type="nucleotide sequence ID" value="XM_025662765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R735"/>
    <dbReference type="GeneID" id="37166167"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF210">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="95"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH59474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="608" mass="66675" checksum="2DE9CEC9B830712B" modified="2022-01-19" version="1">MTGLKSYDYIIVGAGIGGLVLASRLTEDANVNVLLIEAGANRMGDPRIETPGFLETMYGNPDFDWDYMSEPQVHVNNRQIAQPRGRVVGGSSTMNFSVIMYPSEANFAAWKSLGNQGWGPEDMAPYLRKFHTYTPPSEETAAFLSLDKYMKQENQGKEGPVPVTLPNVYGPFNQAWDETFGNLGWRTDADPISGRKIGAFTSPLSVDGATGRRGYAGAYYSPKVAERLNLDLLVETMVERVLLTKDSDGLATATGVQVKTKGEHIREIVANREVIICAGSLNSPQILELSGIGKRDLLEKHNIPVIVDRPGVGENLQDHCLAAVSFEVADGQVSGDITRDPNVVQSLIKLYEETHSGPLAGMPISMAYLPLMDHDGQLSSEKVEELLTKHLDQHLQDASSSQQQQYALQRALLQEGRNASAQYMFLPIQVHMNPGKTTMSDVLAKTLPGNYITILVLHNHPFSRGSVHIRSANADDKPIYDPNYLSHPLDIEILARHVQYLDQIAATEPFSGLLKPGSRLPERAIDLNDLQKTKEIVKERLFTCFHPAGSCAMMPAEMGGVVDSKLKVHGTRNLRVVDASVFPLEPAGNIQATTYAMAERAADLIRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R848</accession>
    <name>A0A8G1R848_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short chain dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_391773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518189.1">
        <property type="nucleotide sequence ID" value="XM_025656822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R848"/>
    <dbReference type="GeneID" id="37160224"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051935">
        <property type="entry name" value="HSDL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="318" mass="34199" checksum="F2E605983F5451E8" modified="2022-01-19" version="1">MTTQSPNPVALVVGASRGIGRQIAIDLAKNGYTVIIAAKSATSPDPTAPFPPDPNSPASTIHTVAREITLAGGTAHPVQVDVRDPTQIDNLVNETVRISGGRLDVLVYNSGAIWWSSVANTPLKRFQLMQRVNPEGLYATIMAALPVFEKNGWKGRIVVVSPPIYSRFFRGKTAYAMGKVGMSVLTRGLAMDWVREGKSDMAITSIWPATAVESAATEMNPANDGDSRKADLRKPTIFSDAILGILNTPAHVVNGLLALDEDFLRDYCGVTDFSKYSVISGSNPRRMMPKEMPVLEVAEQDDEGVRMDSSKGKGGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8J6</accession>
    <name>A0A8G1R8J6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_518105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518508.1">
        <property type="nucleotide sequence ID" value="XM_025664951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8J6"/>
    <dbReference type="GeneID" id="37168353"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="32"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH60586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="548" mass="59374" checksum="77A9008EE440E3C4" modified="2022-01-19" version="1">MGSEVATATSENVFPSFEIPRPTIATWRLVIILLCIAIGLFLSLMDTTIISTMLYTISDEFDGFKTCSWIVLAYTLSYVGCAVFTARLSDVIGRKFLLCMCFLIFLGASMGCAASKNMSQLIGFRAMQGIGGSGLYAMAMIIYPEISPPPLLPAISGIIGMVVALAGISGPLIGGALTSYHTWRWGFWINGPCAFVPLVTLLLVWPNDFHFARNVRFRHLDYLGALLILVGSVLFVFILNEAAIRAYAWNSAPVITVLIISVLSWGALVYWQWVILSKPRFKQIRPQLPFRLLSRRVMVAGFVSTILTGFVMLLAIVNIPMRAQIVNLKDAVASGILLLPLMAGTAVGSAIGGAASAKRNNAFWTLNLASIFMVIGTASLSTLTDSVDPAPMQWGLEAILGFGIGLSLSTITFLTTMQVEFQDHAVAQGIVAQLRIFGGSIGIASGFIVFNTDVQHTLAGVLTPEQLNEFYRTPAAISRLPVLLQLLVRQVYVSTFNTDMRICAGIAAACLVATLCTYQRKPQSIRQRLADLEEAYARTEVARGEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8Y0</accession>
    <name>A0A8G1R8Y0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF453 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_234701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518579.1">
        <property type="nucleotide sequence ID" value="XM_025654798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8Y0"/>
    <dbReference type="GeneID" id="37158200"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="381" mass="40209" checksum="66DECDF73F2F9835" modified="2022-01-19" version="1">MFKYTYRNQVAFSARRYLSKQHSLPAAYYRGGTSRAVMFNQANLPPRSEWDAIFRSVIGSPDPYGRQLDGLGGGISSLSKVCVVGKSTHPDADVDYLFVSLGVKNSDVDYSSNCGNMISAIGPFALDQKLVSSQTPESATVRIHNTNTGKIITASFPVVDGEAASSGDFAIDGVAGTAARIQLDFVNPAGSVTGKMLPTGQTRDEFDGVSATCIDVANPCVFVPASSLGVRGDLTPDEIAAHPDLLQRLDSIRRQAGVKMGIAPTTDAVPGSIPKVCMVSPPQESKAKDSVDLLVRAISVGQPHKAVPITVALAVSAAARVGGSTVEDATNKDRVSDSGLTIGHASGNLLVGAKFEEDQLTAATVFRTARRLFEGQIYWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9Z1</accession>
    <name>A0A8G1R9Z1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein HIR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_446067</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518836.1">
        <property type="nucleotide sequence ID" value="XM_025659413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9Z1"/>
    <dbReference type="GeneID" id="37162815"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000290">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001557">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019015">
        <property type="entry name" value="HIRA_B_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09453">
        <property type="entry name" value="HIRA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="15">
        <location>
            <begin position="28"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="128"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="14">
        <location>
            <begin position="747"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="437"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH60914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1060" mass="114516" checksum="44D55C075279F691" modified="2022-01-19" version="1">MHIIKPVWLTHGGERKDFEVYSCDVSPDGSRLVTAAGDGYVRIWSTEAICNTDDPEQASKPKQLASMSNHSGTIHTVRFSPNGKYLASGADDKIVCIYTLDANPPSHASTFGSNEAPPVENWRTIRRLIGHDNDVQDLGWSYDSSILVSVGLDSKVVVWSGTTFEKLKTLSIHQSHVKGITFDPANKYFATASDDRTVRIFRFTSPAPNSSAHDQMNNFVLEQTISAPFSNSPLTAYFRRCSWSPDGMHIAAANAVNGPVSSVAIINRGSWDGDINLIGHEAPVEVCAFSPRLYSPQPITKPAVDSQGQVVHNSVTVIACAGGDKSLSIWITSNPRPIVVAQELAAKSISDLAWSPDGKCLYATALDGTILAVRFEDGDLGYAMEMEENERSLTKFGTNRKGAGITETTDGLLLEEKSKAGEIKGVEGRMGALMGDDHAAADNTANGKPGSGASNGVTPARAASPTPDTQKSQPNGTAGTPAAQEPEKPDPYQAKLERLKQRPTYTKDGKKRIAPLLVSGAGAAESSLPQARLMASVSSQVKADTPQSIVDLSKPFDGLPKGGLAALLFGNKRKLAQLEGDDDGHVEKRVALASQNGATPILASTPDGLLPAQPQPAPTGQQQTPEFIRPAVMNPCMAISQLRLAVPKVRSQIVRAIDPTGKPTEPNAPGETNKSRVDVVFEARNPSPASLTGRAIDREPVRLTLFRGEQPLWQDFLPRTVLLVTGNLSMWAAACEDGSVYIWTPAGRRLVSALVLEAQPVILECNGPWILCISAVGMCYVWNVKHLSSPHPPISLQPVLDAAVHTLGAHPSAAPAITNARINSEGRVVVALSNGEGYSYSPSMYTWQRISESWWAVGSQYWNTTEAPVGNLQSTDSQDKDAKAAVSAGIVPFLERNTTNETLLRGRAYFLQRLIKVLLSREGYESFESSVSIAHLENRLAAALSLGAKEEFRLYLSMYAKRIGAEGLKMKVEELLKGLIGGLFEEEDADAVRRLQDNEQDDRNWRESSETLCGWPREVLLKEVILALGKHRDLQRVTVPYAKLLGVVDNESEAGDAMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA70</accession>
    <name>A0A8G1RA70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_413118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520055.1">
        <property type="nucleotide sequence ID" value="XM_025657593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA70"/>
    <dbReference type="GeneID" id="37160995"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39632" checksum="A2FA4C3381161383" modified="2022-01-19" version="1">MAHKKDKNSLQLERTALAPVNPCAQNTAPLSSLLDSGLDDIKVPSLQPLSPIKTPSVVRITIQKDPTQRATSLLIDQHVDNLSIPVLEPQRVSPRSNSTTTITQVRPPWLTLLVPWDGTIKWAIRGSSVFETTDEELDALLYRPNIVSKESPTELWMFQFGLRYIPAEGDRDVHRAVTIENLPSDVTLQQLLPLITGEIYSAHFLDTVSITGSNTAFIVFVTQADTVDFLKNSGGSLALRATQAKVTLVPTPTYPMAASMARLVFKEGHTRCVCISGVRDTLKGEIRRVLGRSPFLEYLERIEDGQVLGDVYARFHSIKGATAAYKLLKSHPSFQKCKLRFLAARPLARQPRIGIWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAQ2</accession>
    <name>A0A8G1RAQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_359638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520650.1">
        <property type="nucleotide sequence ID" value="XM_025655520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAQ2"/>
    <dbReference type="GeneID" id="37158922"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="258" mass="29818" checksum="624CCCE96D991963" modified="2022-01-19" version="1" fragment="single">ETLQRSWSLWRKESKVRVRNAGRYYFDFTHWNILVSWVIIIAELVLGTIPDPPWIRMLAMPVPSLFFTFAIEMLIFEFMHVLKIPVPFRISSIAKGDPMRPALYPLIEDIIAVDGNGGTEFRDRLDQRYNASPPFRNMLHRLTILWMVPQMLVAGGTLAGIVIADHELAYTLGWSVPAIWAGIWAMVMVICIRVESRRERHYWDGVRLTQQLQMDRPYNSEVSAQFEGESTLVHSRQYCLGCDGRTTRVVDCIMSEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBN8</accession>
    <name>A0A8G1RBN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ARS binding protein Abp2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_434728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520019.1">
        <property type="nucleotide sequence ID" value="XM_025658483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBN8"/>
    <dbReference type="GeneID" id="37161885"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018562">
        <property type="entry name" value="ARS-binding_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42048">
        <property type="entry name" value="ARS-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42048:SF1">
        <property type="entry name" value="ARS-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09441">
        <property type="entry name" value="Abp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="789" mass="86343" checksum="98A95019979FC3CB" modified="2022-01-19" version="1">MESSFPNVMNQPVPPERTELGPPSMVIQQYARYPPALEPGLHSASPIGSARTHIAPSKSPPLARKATPRSLQASPTGPRPIAPPPPPPPPAMVAHSGPSISPPMYDSIRPRPPRESMDQTETRSLPSRDLTDSSIDDAYIMFVFYCNPNVPLSVDTSELRKNFRCPPRSDGKSFSIFALWELIRKLDSKELKTWIQLAIELGVEPPSLEKKQSTQKVQQYAVRLKRWMRAMHVDAFFEYCLGHPHPYYTHLPPANVISDSRDGVPLEEDLALRALVPQWRPKRGRKRAEEENERLAMAKRPHLDPIMGVLQPGPFPGPPTPYPSGALPFSTFPDEMGSHDPWMGSAPPFPPEGTSEPSSQSNQDLRWRPIERDSSPGSYPHSAIAPRSQHESEVFIQPAEPRSAVTMSSSGEKARPKRRHGPAVSSAWPSNTSSNGKTRGRPPNRGTVSGPFSSFPVNPNRTDPSHLPGPGLRNSPAMLLDQDSAGRFNHSPFQQSPTPFHFGPKPDKLQLQVPPHAGTPVRLATPPTLMVNSINNAPGSTKLEGQGPQRNGTLAPLNDFMSNVGVTNPSAYANRNSVPHADISSDDVVRALSSELLRGKTTGRPAPISTEEARALAMSVVSSLTTTYAKLPAGLAALMSALHLGLGQQFGYPGVTDSLMTVNIKSEPAVTSGTPSTDGSPNYVYTISHEYKHGLRFSTKVTYGDLSISTPTPDSHKLDPTPRVTEELEASIAEADSMTDAEFEVDAENSTPDATWKQRYLKLRAQVQRKERMLSQYKRKILESVMADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBS0</accession>
    <name>A0A8G1RBS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_413391</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520218.1">
        <property type="nucleotide sequence ID" value="XM_025657608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBS0"/>
    <dbReference type="GeneID" id="37161010"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000061">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="92"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH62296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="548" mass="60132" checksum="6DB2C0B7D1846351" modified="2022-01-19" version="1">MHTHEAPSPSESGSADTVYSPELDRPINSVFSQEKDVAAQEIEYLYLELETPLPTPLITAPPGPGQSPPPEPPSLEKYTSPFLWPKWRKWMMTWIACAVTALAGYSAGEVNPASTELTAEWGISAVVYDLSITIFCVGFALAPMVLAPFSEINGRRPIFVASGVLFTACIIACGGTHVFAGLIIARLFQGVGASTFSTMVGGVISDIFHAEERNTPMALFSGAALFGTGLAPLCSSAIVAHTSWRWIYWSHAIVSAFFVVVIYFFFKETRGSVLLSRKAKAVNNYYEQLEAAGHFGVIMGEKNEAKRIRWKVKSDEQRESLVQMISISCYRPFHMLFTEPVVFFFSLWVSFSWAVLYLQFGSIPLVFKTNHHFTTEQTGAVFASMCVGAIIITVVSILQDKIANKYGFLPKKPEARLYFVCVEAILMPIGLFWFGWTSYSSVPWIVPTLAIACATMGIFAVYLAVFNYLADTYHRYASSAIAAQSCCRNLLGGVFPLVTNAMFTNLGYPGASSLLGGIGLLLTLVPWVLVLYGGRIRAKSKLASELAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBX5</accession>
    <name>A0A8G1RBX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_475886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518397.1">
        <property type="nucleotide sequence ID" value="XM_025662752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBX5"/>
    <dbReference type="GeneID" id="37166154"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021709">
        <property type="entry name" value="DUF3292"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694">
        <property type="entry name" value="CONSERVED EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694:SF1">
        <property type="entry name" value="PEROXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11696">
        <property type="entry name" value="DUF3292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="677" mass="74510" checksum="5CB1B1E344A07AB2" modified="2022-01-19" version="1">MSRRDPTKPAEPVAYSSKTSGNDIFAADRVTTEISGPTDSHVLSKVDQDEKGLAQKAGQTDTVTDVGWYQHPDELDEQIVSGISNEDLWMLVRRFNKQIYYVKAVPHSPLQRLDLNRAEDEQFSPDKLRATLERFYTTIIVSLTSFVNHIARLRSWRERQRTAAFCAVYFAAWALDLLAPTIFTLLIVLVISPDSRSYLFPPAPIALVDKDTGGVQKPKAGVLGSHDSITGAPENMKGEAAEQEASNLFTSVASVAVGSVAGKHDQGTPDDAPMEDNAPDVMKLATSAADAQTAARGEAPDEAHDKTRQPMRDTVYNGANMAMRVLSDITDTYERFGNALSPTPPFSIVTPYIRLTAVLSVGFLISLITSSYVFVKMITFGTGFAFFGDPIIWRGVAYLNREYPRWEKLLELQNSLLKGIPTNAQLTLTLLRIGEANGAPLPPPPSHSLHQTPYHPAPLNDKDINISASEEEINQAIAPSPESVIEEHEEHPKPHKKGFINRMIGFFRGTTATGIQSKLAVDRARAAAGSKHAKPRVGVLRSKGKLTLPSGPIQFDGRYKGKRGVVVLDQSQKPPLLYFTTDQTVQLDKPGLEHRPKGTVLFTMPVTDILEMRKIGGLGWKGKLVTGWAVGESKEVVDGMVLTGRLPEQKYQLTAMKTRNQLFNRLVAIDGQVWESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDA7</accession>
    <name>A0A8G1RDA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_444438</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521013.1">
        <property type="nucleotide sequence ID" value="XM_025659016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDA7"/>
    <dbReference type="GeneID" id="37162418"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="331"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH63091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="456" mass="51830" checksum="FB63005A8CF629AE" modified="2022-01-19" version="1">MSAKPADASRPRAADPKKVHIADTVMTRGNWYKHVNWLNVFLIIGIPMYGCVQALWVPLQVKTAIWAVIYYFFTGLGITAGYHRLWAHCSYSARLPLRIWLAAVGGGAVEGSIRWWARDHRAHHRYTDTDKDPYSVRKGLLYSHLGWMVMKQNPKRIGRTDISDLNEDPVVVWQHRNYLKVVFTMGLIVPMLVSGLGWGDWWGGFVYAGILRIFFVQQATFCVNSLAHWLGDQPFDDRNSPRDHVITALVTLGEGYHNFHHEFPSDYRNAIEWHQYDPTKWSIWAWKQLGLAYDLKKFRANEIEKGRVQQLQKKLDQKRSRLDWGTPLDQLPVMEWDDYVEQAKNGRGLIAIAGVVHDVTDFIKDHPGGKAMINSGIGKDATAMFNGGVYYHSNAAHNLLSTMRVGVIRGGCEVEIWKRAQKEGAGYVRDDAGQRVIRAGEQVTKIPEPIPTADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDD0</accession>
    <name>A0A8G1RDD0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_466094</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520292.1">
        <property type="nucleotide sequence ID" value="XM_025662110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDD0"/>
    <dbReference type="GeneID" id="37165512"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000094">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000547">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="200"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="570"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH62370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="635" mass="69687" checksum="0F33F3AA7EDDFE61" modified="2022-01-19" version="1">MAASVLGKRQRGAIEPEVPSLPVRRASRRRTQQPHVRQESEPPAPQPRQLRSRTRNGNGAAIQEEPQEESKNDSVDSGQTRRTVQVGKAAISPVKRSHATDPVNDENSTPVEFKTPSKSRFRDALDSPPPTTPKHRVLIGGKSMTPRTPRHISTPTTTQTIYSEARQMFARGATSTRIVGRDTEREKLTSFIQDGVDSRKGGCLYVSGPPGTGKSALVQEVCHDMDLKSLKIAHLNCASMRGARDVYSRLIGDLCNDHDVFKKSEADRLRLMFTSEEEDDMFLVTLDEIDHLLTADSGILQSLFEWSLQEKSRLLLIGIANALDLTDRSLPQLKAKNLKPRLLPFLPYNAGQIASVITNRLRSLLPEGQTVEPNFVPFVQPAAIQLCSKKVASQTGDLRKAFELVKRAIDLIEQEALKKLEAQNANPESPTKTILVENNNLSSSSKSSSPKQTPTLSYTAITAPRASIAHVARITSAAFGQGTVQRLQGLNLQQKAAICALIALDRKRRQGEFPGTPSKTKHLPPTIKQVYDTYCTLCRQDNILHPLTSTEFKDVLSNLETMGLVGEYQGRGRGGTVAGGSDLRRSPSKLHGPMTPSKALDEQSLVCFVSQKEIETQLTGAGEGILRRLLTGQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1REB3</accession>
    <name>A0A8G1REB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="10">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="9">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_9594</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="9"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520772.1">
        <property type="nucleotide sequence ID" value="XM_025665813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1REB3"/>
    <dbReference type="GeneID" id="37169215"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="11">
        <location>
            <begin position="95"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH62850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="577" mass="63220" checksum="4E3FA4543712177F" modified="2022-01-19" version="1">MAFKLPLSQPSPSVRSLGRRAARAPVLRARGVATVPFRLPAARNEPNLDYTRGSPERAEVEKVLKQMKSQLPLKSQAYVGGKALSISNTLQQPLPAEHATTFTNYPSVNAAQVNAAIDAALEAKEAWQNTPFVDRAAIFLKAAELVAGKYRYELIAATMLGQGKNIWQGEIDAAAELADFFRLNCNYAAELLEKQPDRGTEGMWTRVDYRPLEGFVYAVSPFNFTAIGGNLISGPALMGNVVVWKPSDSNVYASELVYKILLEAGLPPNVIQFVTGDAQEITQTVLGRREFGGLNFTGSSDVFRSLYAQVGENIGKKVYRDYPRLVGETSGKNFHLVHPTADIQSAVYHTLRGAFEYQGQKCSATSRLYLPESRAQEFLEKLKSEINEITIGSPEDMGAFMGPVIHKASFEKIKSVIDASNKDPSLELIAGGTYDGSKGYYVHPTVYRAKDPNHELFDKEIFGPVLTVYVYPDAEWSSVLKTVDQSGGGFALTGAVFAGDRRAIREAEDTLRYSAGNFYINCKTTAALIGQQSFGGSRSSGTNDKAGSANVLMRFASPRTIKEEFFPLNGFRYPSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RF14</accession>
    <name>A0A8G1RF14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_495390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521416.1">
        <property type="nucleotide sequence ID" value="XM_025663911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RF14"/>
    <dbReference type="GeneID" id="37167313"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="43"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH63494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="436" mass="47210" checksum="DF8242D7E46E58F3" modified="2022-01-19" version="1">MHVKCRPPAGNITGSSGSSEAEKQTTTEPVDTVPLPPPDGGLTAWLQVVGAFFLFFNSWGIVNAYGVFQSYYQSDLIPTYSSSAITWIGTVQGFVLFLVGVIVGPIFDKGFLHSLIAFGTFMVVFGLMMTSLSNQYYQLFLAHGITVGIGCAFLFLPSIAIVTTYFTSRRALATGITASGGSIGAVVYPIMFHKLISRVGFGWTTRIIGFVALAGLTISLLVLRRRLPPPTKSRSLLDLAALKEPPFLIFSFGLFFCFVGLYFPFFYLQSYFTYYLHNDSSLAFYIFSVLNATSVLGRITPGLMADRIGGLNTLVPISLLATILAFVWIAVRNVGGAVVFTCLYGYASGAIVSLPPSILTRMSPTLGVVGTRLGMIFMFAGCGFLIGTPIASLLLDLEQGCFWKAQLFSGMFVAAGTICFVVLRVMLWRRGSGLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RHN7</accession>
    <name>A0A8G1RHN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_411528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521427.1">
        <property type="nucleotide sequence ID" value="XM_025657526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RHN7"/>
    <dbReference type="GeneID" id="37160928"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF151">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="31"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH63505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="496" mass="53738" checksum="64E90618076F7160" modified="2022-01-19" version="1">MPPASVGREQSPVVPTEPPFSIFDNRQKWLIVTMVSTAATFSGFASNIYFPALPTIAKDLNVSLELVNLTVTSYLIFQGLAPSLWGPVSDVKGRRVAYTCTFLVFFGACIGLAETKNYATLIILRCLQSTGSASTIAIGSGVIGDITTREERGGYMGIFQAGLLVPVAVGPIIGGAMAGTLGWRSIFWLLAIYGGVFLVLMLLILPETLRSLVANGSQIQPTRNPLVKYPLVVYQKTTQVQWDPSVVIPPAAKKHIDVLGPIRILFSKHSTPIILFLAIYYAVWQMSITAMSSLFTDKYNLSEIQNGLTFIANGVGSMVGTLITGKILDADYRKVKAEYESLSDAEGEAQGEADFPIEKARLRLVPIFAGAQCLSLILFGWTIQYQVHIAVPIISTFITGWTVVSMQSIIMTYLVDIFHERSAAASASINLARCMFAAGGTSFVMPMISGVGAGLTFTICAAVQFVALVGPFIQWRFAARWRQATEAKKRTVGVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGD8</accession>
    <name>A0A8G1VGD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_507847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510068.1">
        <property type="nucleotide sequence ID" value="XM_025664424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGD8"/>
    <dbReference type="GeneID" id="37167826"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="189" mass="21375" checksum="449B0AC603B0FE79" modified="2022-01-19" version="1">MMSADTYNILNFADTLKRSFEEKVDEHGNVTKRGFKRGDLNVLSTLHYWLQPSPELQGDLYNANLIMCSRKYGPVFVAVGCEAPDTLLSPDGQAPDWARERVKVVCDLLRSKLRSLFADKKNKPREGWPQYGAVIHGQEICVFKVDLEGGAHKVVFEGETVHDILWGRIIRLLDGIVEEFQIPDELGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VH48</accession>
    <name>A0A8G1VH48_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_472153</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510938.1">
        <property type="nucleotide sequence ID" value="XM_025662536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VH48"/>
    <dbReference type="GeneID" id="37165938"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="63"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH53016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="466" mass="50662" checksum="3D234A346FB7428C" modified="2022-01-19" version="1">MAHPTGDKVDSHLNVQTGQFFQEGREDPYLHDAEEKQDDKKDSPVYNDTFGDEEYAEVKYKVLSWWQCGFLMVAETVSLGILSLPAVVATLGLVPAIVLIVGLGLLATYTGYVIGQFRWRYPHVQNLADAGEILFGSIGREIFGIGQLLLVIFIMASHLLTFSVAMNTITEHGTCSIVFGVVGLVICYFLGLPRTSANVSYLSVASFISVFSAVMIVMIAVGVERPYKGTLEATVDTSLYEAFLAVCNIVFSFSGHVAFFGFMSELKDHREYPKALCLLQGLDTILYLVTSVVIYIYAGPNVTSPALGSASELVGKIAYGIALPTIIIGGVVNGHVACKYVYVRIFRHGDRMHSRDLVATGSWVGIALGLWIIAWIIAEAIPVFNDLLSLIASLFASWSTFGFSGMFWLYLNKDRLFSSPKKIALTILNVIIIGIAACICGLGLYVSGRSLHDDANSSSFSCASNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHB1</accession>
    <name>A0A8G1VHB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone acetyltransferase Spt10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_454278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509979.1">
        <property type="nucleotide sequence ID" value="XM_025661245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHB1"/>
    <dbReference type="GeneID" id="37164647"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015416">
        <property type="entry name" value="Znf_H2C2_histone_UAS-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF2">
        <property type="entry name" value="PROTEIN SPT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09337">
        <property type="entry name" value="zf-H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="524" mass="58503" checksum="547D3AC84CB13746" modified="2022-01-19" version="1">MPAVHGDLMTTVVPTEKELPLDIVPRQVILRDRVTVATLVPFTSADAIPRSLLAYLSDQLNKEIEGGDTYAMIDPIPLEQFGPYWFSNFGAIMLMGDIKSVQEVQALGRNRANWSKICLGSFNIRPNYPGRSSHVCNGMFLVTDAARNKGVGRLMGEGYLEWAPKMGYTYAVFNLVYESNVASCRLWDALGFKRIGRVPGGGRLISNPGQYVDAIIYGRDLGPEGEDSVTQDRFDKIRYYLKHSKYPRGADRAEKSRLRSAATHYKLIGGKDGDGEKLMLKDKEVVSDPQQQYDIAREMHMQQHAGINKTTAAIAVKYHWVRIKETVSRVIRDCPQCKEILKPPLINGIMHEGTPEDDEDDLGIDEADLAENDVDMASSDPMGTHALMDHAAMDAHNTNPFVTAHSVVQGSVDSITDYTGLPLDPQIIDIHQQLPRFHPHDTMTDPYTHAAHSLHASSFDNDVRHHAAHDYHMMVDHPTDPDPSAALHQEVLGLVHSQAHDVHHEQILAKYQYVDQPDDGLDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIH4</accession>
    <name>A0A8G1VIH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cation diffusion facilitator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_452398</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512451.1">
        <property type="nucleotide sequence ID" value="XM_025660814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIH4"/>
    <dbReference type="GeneID" id="37164216"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000003">
        <property type="entry name" value="Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF12">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="144"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="9">
        <location>
            <begin position="356"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH54529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="430" mass="47930" checksum="263670A85836389F" modified="2022-01-19" version="1">MTDPPQTIPLHHLPSSISYNAATTTALESHLSTSDEESSPPPRYTRENDPFQLASKLKSPEEIARMQPQANISRKRHTSGCLPHSANPRNALASSLASKQLQTFYESQNENIQRMLKPVEEHVRDARETNSSNQLKYKIAVWGSFAANVILCVLQLYGAISSSSLSLYTTMADAVFDPLSNITLLVSNKAVNRVDPRKFPAGKARIETAGNICFCFLMTAVSFILIAFSIRELAEGSNSETGSFHLPSVVAVIVAFCTKFALFLYCFALKDQYSQVMILWEDHRNDLLINGFGILTSVGGGKLRWWIDPAGAIVLSVLVSCLWLFSAYREFQLLIGVTADTKMQQLITYISMTHSPLITAIDTVRAYTSGPRLLVEVDIVMDPNDSLRATHDVAEELQMKLESLPDVERAYVHVDYETTHKPEHFLKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIL1</accession>
    <name>A0A8G1VIL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid synthase subunit alpha</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
            <ecNumber evidence="4">2.3.1.41</ecNumber>
            <ecNumber evidence="2">2.3.1.86</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BO85DRAFT_500438</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 17">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EC" id="2.3.1.41" evidence="4"/>
    <dbReference type="EC" id="2.3.1.86" evidence="2"/>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512393.1">
        <property type="nucleotide sequence ID" value="XM_025664120.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37167522"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2490:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026025">
        <property type="entry name" value="FAS_alpha_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000454">
        <property type="entry name" value="FAS_yeast_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 17 19" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="21">
        <location>
            <begin position="151"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="22">
        <location>
            <begin position="1011"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="98"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1242"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="18">
        <location>
            <position position="1195"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="19">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RAH54471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1627" mass="178959" checksum="12884D1A15CE2749" modified="2022-01-19" version="1">MASKEKIHPRVHRELAYVLLTELLAYQFASPVRWIETQDVVLQEQKVDRLIEIGPAETLLGMIKKTLAAKYQVHDAALAIERDIWSHKKNAREIYYESSEDELAPAQTSKESSTPAAHPSQPTTPVTPPKAADTTTPQPAPVRQASSNIEDKTIAAIDIIIALIAHKLKKPLQDIDLSQTIKKLVGGRSTLENEIVGDIGAEFGSIPDAPEDTPLSELAQSIEAHGSWKKGLGKTTQTLVNRMVSAKMPAGLGSGEVRAHLLSKYGLQTGRQDAVLLRAAVQQPAARLPDTSAAHAFLDDTVQQYAQDSKIDLSSAGTSSDGAGPSSGPVVVDQTAVKALAKSQDDRAQAMLEVYAKLLGNDLQAGHKANTKAAEVIADLQDELQLWISEHGEVYGSGIKPMLSVAKARRYDSFWNWAMQDAVDMFHHILAGTIALTGREIETIMGRIARKSNPKLVQMLEYLETQCLKLRDPRAIHARDVLRQLRLACNPQLSGAQPLTAHRLVVDAPKTTIDSQGKIHYTEVPRATVDAASPATLKSLGSQGWESRADLNAAFMATLGQTDNQCLSFSDAEVLVIGAGRDSIGTEIVRGLLRGGARVLVTTSSYSLATTRLYQQLYAEEGSHGSQLILLPFNQASQRDLESLVSYIYDSDKGLGWDLSHVVPFAAIPEGGRQIEDIDSKSELAHRIMLTNTIRLLGVIKKQKQTRGFDSHPAQVILPLSPNHGIFGGDGLYPESKLALETLFNRWSSESWGAYLSICGAIIGWTRGTGLMSANNSVAEDIEKMGVRTFSQVEMAHYILILMSSPIATECEVTPVRADLSGGMGHFPNFKEAVDSIRQKQKETSEIQEALAKEEVFERAALGKPSEETPQVREQKARLALDFPRLPEYQTEILPLAGQLRGMVDLDRVVVVTGFSEVGPYGNARTRWEMEAYGEFSLEGCIEMAWVMGLIKHHNGPLNGNPHYHGWIVVETMEPIRDVDVKKRFEEHILAHTGIRLIEPDINDGYDPYKKKFLQEVVLDEDMPPLKTSKETAEQLRLEHGDKVEILPEGEEYTIRLLKGACLMIPKALRFDRAVAGQIPTGWDARTYGLTEDLASQVDPATLYALIGTVEALLSAGISDPFEIYQYLHVSEIGNCIGSGLGGVKALRKLHKDRFVEKQVQNDILQESFINTTAAWINMLLLSSTGPIRTPVGACATSIESLESGYETIVSGKAKMCLVGGFDDFSEDVSYEFAKMKATVSSEEEIEKGRDPSEMSRPAASTRAGFVESQGSGIQVITSAQLALDMGLPIQGIIAWVGTASDKIGRSVPAPGKGLLTNAREAQHRVPSPMLEISYRRRRLNMSLQHIKERVDMEVDIAEAELADLKRSPSPYAEERTEEINERLRYVRREARIQEKDALNTFGNHFWKNDPEISPLRGALATWNLTINDLDVVSFHGTSTVLNEKNETNMISQQLHHLGRTKGNPALGIFQKYLTGHSKGAAGAWMLNGGLQVLNTGLVPGNRNADNIDAALQNDYLVYPSRSIQTTGVKAFSVTSFGFGQKGAQALGVHSRYLFATLDQATYDAYRVRVEARQRRAQQHFRFGITQNAVFSAKETPPYRSYQEFRVLLDPEARLTDNGRGQMEYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIZ8</accession>
    <name>A0A8G1VIZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_523429</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511704.1">
        <property type="nucleotide sequence ID" value="XM_025665348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIZ8"/>
    <dbReference type="GeneID" id="37168750"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08234">
        <property type="entry name" value="threonine_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="26"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="171"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH53782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="344" mass="37560" checksum="AC7207721891E812" modified="2022-01-19" version="1">MTVGNVEYSEARKFSIVEKKLPSIRAHDILIKVKACGVCGTDLHIHEGEFGAQFPLVPGHETVGIVAAFGSEVVDFTVGDRVVADNSELCGHCHYCRRGKELFCENFIAHGVMVDGGFAEYAAYPAHRVFKIQNLSDADATLLEPAACAAHGLDKISPQMGSSVLLFGAGPTGLMLAQLLRQNGGCRTVIAAPGGLKMELAKSLDAADEFVDLPREEDAAAARLEQLRREYPYGFDIVVEATGSERVLENAIHFVTKGGKLVVYGVYNDESRISLSPNKIFKEEIHVLGSFSQTYKFPAAIDYLDRGRINVSGIVNKTFKLDEWEMCLDAMRRKSVVKAAIVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ81</accession>
    <name>A0A8G1VJ81_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB domain and ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_425607</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513068.1">
        <property type="nucleotide sequence ID" value="XM_025658083.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37161485"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="351"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="405"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="913"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1138"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1199"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1251"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1520"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="594"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1169"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1342"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1367"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1416"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1437"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1468"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1491"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1549"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1599"/>
            <end position="1609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH55146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1654" mass="181998" checksum="9CB827F2D927A5E6" modified="2022-01-19" version="1">MSSKLWGFFFYDDVESFRRFLATATYTTGGSQRTGIGGASPFKPGSPGSVIASSPGTSTKSRKLTGTSPGTPIPDRGGSLRPGKTLSREELNARDHHGRTLLHHVASSPKDTAIEFAIALLEIPALDIYAQDWESGWTALHRALYAGNATIAQALMARDMRDATDFSKAGNPGHPSGGLIRIKDREGYSPFDVYGATIATRDIKRISSRTTAQAPLLADMDNSDAASDVSSHGEGFDEDSRSARSIVKPRTNLSGDEVFTFGSNKNLNLGVGDQDDRQYPERITLKRPEHLLQRFYREFLEQRSNDDTFDPNQEPGYSTDLPALVKNKPIKIQNIVMSKLHTAILTTDPESNLFLCGFGPGGRLGTGDESTRFSFVCIDTGGLANRRVVSVALGQDHTLAITDRGEIFSWGSNKFGQLGYSLPRSNNRDDVPIQNSPRQIFNPFKKEVILGAAASAIHSVVFSTSGLYTFGKNEGQLGLVDSDARSLEIQTTPRRVGASLFSAPIQSVSAIDQATAVLLQNHEVWVFSQYGYSKLLFPLDVSSRFIKDSFMATRYGSSVNEIVQVKSGGNTICALSSFGEVYTVQVNKTEHPPVSTSTTNPSKTRNSLSQPTRVWSIKKAHMAAADVDVGQDGSIVICTVSGSAWRKEKRGKTKDGASKDYKFARVPGLSRVIGVSSNAFGAYAAVQRDSEVTKEQISVDQSTLWKDILPLSPFNSLQETIDPRSQTDEKDVHTDMEPAMAIRRAVMSSSEIEPLFQTSQSRAPAGTVWLRTSQSDIQVPVHEFILTGRSLVLRKAFQDFRGTDHASVPDTVTIQRDDRGQTHVIMHGVDVLTVLNIAFFVYTDSILDVWQQVRYSPESASRYRQVRSEVMRIASHLGLSTLERAARLMIEPTKSLKVDMERAIRDPAFFDSADVVIELNGSEVKAHSQVICQRCPFFNALFFGRSEGMWLLSRRADPEHMVRIDLRHFEPNVFNFVLRYMYADTEAELFDDVRSRDLEDFIDLVLDVAFVANELMIDRLAQICQKMLGMFVNTRSVCHLLNAIAPCFVTEFKDAALEYICLNLEDLLANRLLEDLDDILLGALDTVCRDNQMASFPVSRGRNTEEYVLEKYPEVVSLIEEDRKRRIDSMRIRSRLNRIDASEGKPRMMSNEKAAVSPLAQRVKATPAKDSSTPASSSPLLKSRQSVGDLMFQMDDEYLLSPGESGKGKGVVREDKSPAANKHKPSFDSPALGSSLVDGDSFGSRSYLDDQMASSRDLAVPESPSETRAASLYKKRNGSLTPPDAQPPWSSSALSSSKKSLKDIMSEASENRVSNLSLGMGARRENNNATSKLSQKERKKIQQQQMQDMLAAQQKAKEGPQNPWKLPSTSSPAHVNEQQASPSEGSARSTPKPSMTLRQTVAGTPPPGTKPKTTPIQGQGRSTPNKVQTPSKPSLPVPSTAAPSTSNPSANPQPPIQSIRHIPRPEPYQTSFHTPSANSLSLATILMQQQTEKEELHEAATAKHNLEDIQLEQQFQEWWDKESRRVQGLPDPGSAPDTTAQEARDGRGNRGRGKGQGHQQRKRRGKGDGPNGTIDTSTPQSSQPQPPPPSQPPRKDQRQQQQQQKKTPSAPRREQQPQRPQANGNHPDTTSGSSRRGGRGAARGRGNRERGKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJH9</accession>
    <name>A0A8G1VJH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_383034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510685.1">
        <property type="nucleotide sequence ID" value="XM_025656496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJH9"/>
    <dbReference type="GeneID" id="37159898"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="43054" checksum="22288AA9051EEB61" modified="2022-01-19" version="1">MRPYSIDGAMAEALNHLNLISCHFRVHGQHHVANEIGKLSIIIVNKFSEGVEHLSPEQYVLAPEQDSVTQESASTQLSSHIDNQKPNGSAYLCDTEKENNGYVDGTRKMPEGRHLHTGSWAQVAGSISNGHSHEVQCMSPMSLVLGSVSKPSQSSDDGTEGRESGNAGVTLPASVSPDIPDAKAGVIRVYGKITRDFIQYITTRIHEGPLQDIRVETNGRTKVTFQHAAQALAFLNSNQDMERMLGYGRLGEGYRVELAEIIDWNEDLRRMNQPIRERRRLSFARKRLFAEGMSPDKWKQDIRALAGPGNIDFLWVFNSGNATAVFTSTVVARRVLEVFEDWKNGRNVYSGVSVTYSSDPCEKELVLVRETNRPGMARNFIKRTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK52</accession>
    <name>A0A8G1VK52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_497089</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514296.1">
        <property type="nucleotide sequence ID" value="XM_025663978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK52"/>
    <dbReference type="GeneID" id="37167380"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH56374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="592" mass="66911" checksum="37164AEA869903F4" modified="2022-01-19" version="1">MTSRTSKYRVSQREARAFTRKRAVAACRVCRSRKIKCDNARPTCSSCQLSESHCVYQDHVDFSKFDPATIAILDRLTEIQQSLNSINPEGVTAALPSKGPLKQYMADLSPQMPQNVSLKIPAARICPDAILSWPIFKEVRLQTTLNSLTLADHDHVLEEVASTDVDLALIPYLIDRFLQFVHVKNPVVNTVVLRQSAVRVEVGESSRNAHSCLVFLACALGCLAGPLRYDDRSVERDDHAESLRATGEQFYQKALERLSLPGDRILTTQCWFLSGVYQMYKLNAARAWMDFSRASAILSLHLQHREAAVGNDSNGRHLDPAELSLYWTCWNDLRAELNIPDSILCEFNVSDGYPIPSSASATDSEAVLSGTPTDSEDLSHLWKLSTYYYLSDVALMRVEAQILNFMYSTNDSQWSPANLSYMCRTAADLESQIDHWSRNRPSIIHFEEWDSAPRFELTYNLQARVLQLRSWLYRPFVYYAIHHDGEQINENEEAKKFMRKAIECSFHMINSKATQHRHHGTWFVARGVLSSALLIIAAVKADKGLVDYLADWPDLLDQAIRSLTHWASEARDLAYAAVVLANLKGKLCTQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKB3</accession>
    <name>A0A8G1VKB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_73065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513427.1">
        <property type="nucleotide sequence ID" value="XM_025665621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKB3"/>
    <dbReference type="GeneID" id="37169023"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="10897" checksum="349A4869E6244F3F" modified="2022-01-19" version="1">MMNGVPADAQGIPFEAGTGPLPTGAEDGFDPNVLLDPKTGKVVYKSQDQKAATKVKSTGPPGMLRIYTDGSSLKNGKALASAGVGVYFGPGDSRFVLPDARRLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKU7</accession>
    <name>A0A8G1VKU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oligosaccharyltransferase subunit ribophorin II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_449859</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515061.1">
        <property type="nucleotide sequence ID" value="XM_025660254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKU7"/>
    <dbReference type="GeneID" id="37163656"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044214050" evidence="8">
        <location>
            <begin position="24"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="9">
        <location>
            <begin position="181"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH57139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="289" mass="30735" checksum="72F96B265B95C512" modified="2022-01-19" version="1">MQLWHSVLQLSLLASAAIPTAAASAWGFTDATVSVNTKGAGVGAGVKEVIPDNKALTKPVALGVADTLKVTLTAQEGRTGKHAHQVYLLLQDPETGLDISYPFNVKDNGKSRLDLTQKDLPVQFLSASEPLEARFLIGSFGESTAYNAAAFQLDVARNADEPVPTVEVSRYGKLPEIHHIFKSDPQSPPIVITLAFVAMVLATLPVLGGVWLFLGVNVNHLPTALKSAPIPHIVFLGSLLSIEGIFFLYYSSWTLFQILPAVAVAGSVAFVSGSRALGEVQGRRLAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL09</accession>
    <name>A0A8G1VL09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_471426</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512155.1">
        <property type="nucleotide sequence ID" value="XM_025662473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL09"/>
    <dbReference type="GeneID" id="37165875"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH54233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="335" mass="36074" checksum="75548A44A4BBC445" modified="2022-01-19" version="1">MPMNKLGPAIQAGNSIILKPSPFTPYTLPKICEFAQQLFPPGVIQCLGSSDDDESHNLGSLMTQHPGIGKISLTGSVSTGKKVMAACAGTLKRVTLELGGNDACIVCPDVRDIEHVAGEIVLSAFLNTGQVCVATKRVYIHEDVYGVVRDAIVNKVREMKVGDGAVEDGVMVGPVQNRMQFERVKGLVDEVKKLGYEVLATGQKYGFDGVGEGKQEGGYFLPLMVVDNPPRESRLVREEQFGPILPLLRWSSESEVVHWANDTPTGLSASVWSGDIARARRIAAQLDVGSVYINSTQKPSFQGLFGGHKESGIGVEFGQAGLLQYCNAKSTYISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLE6</accession>
    <name>A0A8G1VLE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SNP3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_448839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515661.1">
        <property type="nucleotide sequence ID" value="XM_025660035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLE6"/>
    <dbReference type="GeneID" id="37163437"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF103">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="763"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="965"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="971"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="986" mass="108832" checksum="8BA33A9AE99000BC" modified="2022-01-19" version="1">MTDVYRPATGRCPPLRQVRGTRLDTIVEDAREAHYADSTKPVASSAKQTTPKAPQPPQPPQLKLKTSGLSSVSRLPRFFSPISAGSVSSCSDTEWQRQMQPFEDLYDATDDDSDISDECTSFASTRPTSLVTPTTRTSVFSPVSRSRYPSLTIPSSTMWPSLHGAAKSSPIPPTPPPKIPVSPAALSMLAHSVPAVHAPPSLDGSVSSDQVSNISAPATPDLQSLPDNDWTAQDVHVRHELEDSQDEDLEAEPDTQSIQIAIESANEDWRQVLGRFPRIPGGQSTASSIDLDAEPVRGDTPSDRGVSLPADALETLRHISLDGTPDPWSETSESNEEMWQIRMPPERPRSADDATPASELSGYSFSRLSIPSPGGFFASLGPRARHTWSIPCGNKPPTSATAEGFYKLPFSRTEGEVVEHVIEYPERTTEEQLTAVYDPIGPPTAIRIPEEKTPKLSDQFDDQACSEDDAMDDALPPIGPDDQYERDEDYESELKQKAMSGLDRTSDWLAAQASYLSALNETNPVNMLDEEAYNEEVGPKTDRQSPKQLSRKQSVRFAKALPEAPSSCPSLLASRDSIYWRGFKAVQQQSGTRDTFVHRNTRFDAVQSVRLGLTDAHIKRLRGNYEIARPERPAYKGPFSLAPRNSTMDSALAEKAQFSIVEKEQTVLSQIRQPMWAMDALRYINGGRLIVSPALKQLSSTRKRTPRQLRILDLGGHASCEWAWQLAHEYPHVKVYTVFTEHQEVNPGIKGPPNHRHLPVSQLWKLPFADNKFDVISARSLPALLKKECPSGETQDQYDLCLKECRRCLKPGGYLEFFVMDAEITRAGPQASARSAEFASGLRALGYDSTPTKGFLSRLQKNFADVKRAWMFLPMGTEPVKSEPPRETPDPRVKSLIEECEAVQGPVGSTADIASVTGVLGGWIWEQWLVKLQTELGMDQQDLLAGIGSVFDEGRKNGAGWTCLSGWAMKPRPKKKKRHGRKSSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN79</accession>
    <name>A0A8G1VN79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_518327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517433.1">
        <property type="nucleotide sequence ID" value="XM_025664968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN79"/>
    <dbReference type="GeneID" id="37168370"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="77" mass="8420" checksum="6BD89F71B140D4B2" modified="2022-01-19" version="1">MSTTSEKNTMGIAVEEVRKPEPELGGQNHSSPSLEDLIEEVPPVEDSPSLIETIGYLLSIQDGYGPPDSTWDVEDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPA6</accession>
    <name>A0A8G1VPA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_177390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518706.1">
        <property type="nucleotide sequence ID" value="XM_025654331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPA6"/>
    <dbReference type="GeneID" id="37157733"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="108" mass="12476" checksum="6C3129EDDB2A0A02" modified="2022-01-19" version="1">MQTWMFPRRQHVHSFNNINIIFHVHRITLNVLVYLAILTMIESLVLFSLVRDSIHDYPANPLLHLDDVKWGRSELAKDSPPEKILMRSSGIILFLPLSSSFIKLACPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPS1</accession>
    <name>A0A8G1VPS1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA-directed RNA polymerases I and III 40 kDa polypeptide</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_486430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517914.1">
        <property type="nucleotide sequence ID" value="XM_025663391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPS1"/>
    <dbReference type="GeneID" id="37166793"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000003">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000005">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="63"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH59992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="373" mass="42301" checksum="62C264DA08E2095D" modified="2022-01-19" version="1">MAPLVPSQEELDRRRIVDINPETVSNIPSTDFPGHWPGESHEWSLEKFKNDLKIDFHRNERFEASFSLIGVDASIANAFRRILMAEVPSIAIEYVFVHNNTSVIQDEVLAQRLGLIPLKGSVEGINWMRWFKKPTDDDPNGSNPADYNTIVLRLDVECTKNPNADPEEDDPRKLYKNAHVYAKDITFHPVGRQEQFFAGDDAIQPVNPDILVAKLRPGQSIEMELHCIKGIGADHAKFSPVATATYRLLPDIKILRPIIGDDAKKFAKCFPSGVIGLEKVTREEAKQKDSGYEGHEGELKAVVVDPFKDTVSRECLRHEEFQGKVKLGRVRDHFIFNIESVGQFESDTLFLESVKVLKLKCARWKRGLTDLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQK0</accession>
    <name>A0A8G1VQK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CUE domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_390389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518754.1">
        <property type="nucleotide sequence ID" value="XM_025656771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQK0"/>
    <dbReference type="GeneID" id="37160173"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000064">
        <property type="entry name" value="Similar to CUE domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="68"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="392" mass="43148" checksum="90F52BF9FBBED7F2" modified="2022-01-19" version="1">MSEEDKTTPNKLSTGPLSPKPESPTTARPLDFDDEPQETGVTAAPSTAPTQQGAAEAAPPKPPRPLSPRQQAENTLKEAFPSIEASVIKAVLVASNWDVERSFHALLSMTDPSAAEQDAPPPKPPRPTAAQRQLEADEMYARQLAEHYNRPARQPRWDNEYPQQRPRRGSDGSEEKEYSFFDDDLPVIRENLRKGFLDTQTKVNSWVQNLKKRLDGEPEAGPSGQGQPEENYGRPRRSGDLGRRSGDRERYDADHRILNDDFASLELRDAEAPPPRPPRPLANPDLFKSSSPSPDRRKVSFQEGPPTEIDNLYDASEPVRRTSPATGKSSKWQPLSTVDPSPVGEHDPFSLGDSDDEKEKEAKAKEQSTAEAGSASEASKDNSSKAENAGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR84</accession>
    <name>A0A8G1VR84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_447410</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517450.1">
        <property type="nucleotide sequence ID" value="XM_025659715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR84"/>
    <dbReference type="GeneID" id="37163117"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01366">
        <property type="entry name" value="KISc_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000065">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="317"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="80"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="206"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="410"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH59528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="666" mass="75194" checksum="63D26A09F7D0A23D" modified="2022-01-19" version="1">MSRSHSVASSRRPNGHGIPRPATSLDTHDEEDSAATVLGKRKGAEWDQESREKTMEDLMNTFVTKMSQAGQESTGMKEALELYKSRVSELEASRKEITDMNLSLRVEMESLKVRLGASEDALKDAQREHEMEIDEIGSRQRRELESARFDAKRELESLASQHQEEIRELKRRFDHEMEDERAARLREISQMTSQTAIDTQKTNMELERKEREITTLHNDMQALRAELERERKSNRDLRQNLDTASSNSVTMESSVRALKARIEFLESGREEQSQAFERLNQQMMDALAETNATKDKLRKEETLRRKLHNQVQELKGNIRVFCRVRPSLPSDPPTGSAQIQYPDETEDSKEIAVLGPEEKSSLGTITRKNSNFSFDRVFGPSTQNAEVFDEISQLVQSALDGYNVCIFCYGQTGSGKTYTMSSLDGMIPRAVHQIYETATGLEEKGWRYTMEGNFVEVYNENLNDLLGNPEELDKKKLDIRHDMQRGKTIITDVTTVRLESPEMVETILKRAASNRSVAATKANERSSRSHSVFILKLIGENDITGERSEGTLNLVDLAGSERLSHSGATGERLKETQNINRSLSCLGDVIAALGQGKEGGHIPYRNSKLTYLLQFSLGGNSKTLMFVMVSPLQAHLAETLTSLKFATKVHNTHIGTAKRQARVRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRD0</accession>
    <name>A0A8G1VRD0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_388777</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519697.1">
        <property type="nucleotide sequence ID" value="XM_025656725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRD0"/>
    <dbReference type="GeneID" id="37160127"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH61775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="362" mass="40916" checksum="2F3E60FB50FEFF94" modified="2022-01-19" version="1">MVTQRDRELFRDDIRSRGTKLNAAEREKLLRPYLPDPSDLPRRPTQRRKKAPRKTPIRTFVKSQLHLLTYAIVHIIFGIFSRLILSYHAVVDRIFAIVYYHHRTPELIRKDVKGLKRLPEHLSVILSLRKEDDALAILMDEVAELSAWSVSSGIPVLSVYEKTGILKSCIPVLHEAITSKLSSYYGSPAQQPTLRLFAPHHPIYDTQQDVPPSDRHNASSLTVLLLSATDGRETFVDLTKTLAEMSQTGKLSPEDITMELVDAEISEITTQPTQPTAPVNQGSTRMGLSRNASLVKPEPDLLLVFGPFLKLDGYPPWHIRLTEMYCTGGRNSGITNSDEAVEYHGFLRGLWHYAGAQMRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRH0</accession>
    <name>A0A8G1VRH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_482901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520971.1">
        <property type="nucleotide sequence ID" value="XM_025663127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRH0"/>
    <dbReference type="GeneID" id="37166529"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="116" mass="13134" checksum="5F37A0D1A3F93D62" modified="2022-01-19" version="1">MLIFLGKLTYPPYATNELFAVIFSNNMQQGEKVAVVHQWTKDAAGQEKANSFAQGTVDKAVITSAGEKEMEFFYGERETTYYWYKGTQSGSKLTLSMFNKSGEEVVKKIELLATYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRH5</accession>
    <name>A0A8G1VRH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_515625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520986.1">
        <property type="nucleotide sequence ID" value="XM_025664795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRH5"/>
    <dbReference type="GeneID" id="37168197"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000500">
        <property type="term" value="C:RNA polymerase I upstream activating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039601">
        <property type="entry name" value="Rrn5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="683"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="725" mass="81765" checksum="F1696D4D39416AB6" modified="2022-01-19" version="1">MSSPTPYEPDEDDDDTSEYKLKIKRSQTSAPLPVPPSTGPTSSTTNPPVQTSKTERRSARGTRAQALEDLQLSLSKESAEAYSSVLAGIIEDHAPVPTINGGENHITSQNGIVTWTPKEKEVLYHVLDRKSKDGVQEISRQLGSKSELEVQEHLNLLHTGLERQHLKDRHTRTIILGEVPAAAEISKDCCDELDQYAELVSMEEQLAEDVAGKQKHQDLWIINRETAEELSQKVKSQGADPSASSSAHLTAELFNMRKWIRLSERFFMNFGGARLEDNWTNVAFADETPSMTADSFADFYALTISLTRRLVQSSLFFAMSRLRNMRQTGNQKANVVRSRDVKTALDVLNMQRDRSDYWVGLARRCSLKVEDSRHRKGWKSIHMEHDEVEDILSGKIPLESESRERSASRGRSGSRAPENTDVEDPDYSDDESEYSSAASSVLSSPTLSPVEEQSTDPEDDHAEQVDGQMSRLEEVGLWKLIGEPPPQSLETRIQKYDAQDAFPRRPVGQRKTKEDLVDWRDRTFYRSEWEEYGHDLVDLYDELSENRRKRRRFDQTDTKLTDRLIPTPDQPRAGLFDTRVMENDSDHANDEDDYDEMRVDEPIPSKSEIEEFPDREGSSSQGESPISEHASRLIEELGGHSEGYQPRRDLRSGVMLVPSKATEADSPPRRRLRGAIKPESDSEAASSTDDNLSELQAASSEEEETDEGEVPLYSHPMSPADPVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRJ9</accession>
    <name>A0A8G1VRJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_483996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519907.1">
        <property type="nucleotide sequence ID" value="XM_025663204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRJ9"/>
    <dbReference type="GeneID" id="37166606"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="312"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH61985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="622" mass="69605" checksum="82163634417DBBB8" modified="2022-01-19" version="1">MSSPTSSLRHEDFTVAWICALPVEMAAAEALLDERLPDLPAQPHDNNTYTFGVCHGHRVVIASLPSGVYGTNPAAVIATEVRIRFPSLRFGLMVGVGGGVRDAGVRLGDVVTPGSTSAKAESGLGVSLKSPCGKPLYGGYFSVSAIIRRYAKWGNASVEQPCGIHYGLIASGNMVVKDGKLRDKIAKKYGILCFEMEAAGLMDNFPCLVIRGICDYADTHKKKDWQGYASLTAAAYAKELLAVIPTHSVLETPTAALSLDWQIGNDSSRREPLSSGWVSKSRFAFDDDFLARITRYDHERVHQRLSRKRLLGTTQWFLDHPEFQAWFSNRAYPWLWCSGKIGSGKSIIAATAIEEARRKSLQPHAPIIFFYCDVQYDSDLSQLLSSLIRQLTEFIIKRAQPFSENGQKMLQRYFGSEREVPDIDDLEDIFAILSSDVSNATYVIDGLDALEQADARRLLTCFRSLCRTGGDKAIGPRLLIFSREYFVGGTSVATYLPKVPQISTTYNVLQDIQVYIRESIADRMVLQPLTEDNRLIRDMENILLQESSGMFLWVYLQIEVIWYTCATEQEIRVALATLPKGLEETYQRCLKRINVTIFVLSEHLFGFASVHDRFIVKNCRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRM1</accession>
    <name>A0A8G1VRM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="6">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_389239</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="6"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519939.1">
        <property type="nucleotide sequence ID" value="XM_025656738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRM1"/>
    <dbReference type="GeneID" id="37160140"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF14">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE HST2-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 10">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="27"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="37"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="203"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="227"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH62017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="324" mass="35814" checksum="BF6BA03CF2B8EF5D" modified="2022-01-19" version="1">MTSTSSEIEIAAQHLAKAKRIVILTGAGISTAAGIPDFRSPTSGLYAKLAPLKLPFPEAIFHISYFTHTPEPFYAIAKARHPRCLKPTRSHAFLGLLARKGLLHFLFTQNTDGLEENAFVPADKMLAVHGNWKTQRCHKCNTPYPDELMKKAIAKREVPYCLEARCKGAVKPDVVFFGQSLPAAFDEKEKLVAEADLVIVMGTSLKVAPCSRLPRLAREGVPRILINMESAGDFGTRPEDVQILGSCDDGLEKLADLLGWSEELDSLWAAATKEKPTDDEEEISLDECINRLVQKNQGKQVSDGHKRMLETHLQSKFAHVLRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRR9</accession>
    <name>A0A8G1VRR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_128558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520117.1">
        <property type="nucleotide sequence ID" value="XM_025653968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRR9"/>
    <dbReference type="GeneID" id="37157370"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="353" mass="38883" checksum="AEDCED89CA8B4D56" modified="2022-01-19" version="1">MPPRVRISSGRITQSVRRQRVVYQHELPIAARYASTAATATTPAASIEQMTHSPAPIAHYPPTQPPSHRNPEYRRSQLLRQYTSIIRTTPLMVFLQHDNLQSVEWAAIRRELSAAMQKVDEKIASEGRKAPALAPHIKVQIVQTRIFEVALRIVEYFRPKQTTPVPRAVDPATQTSAEIPLAASRDDPTLSHDLSRAAHDAVLSMKGKHELSELLVGPVAVLTIPHVSPEHLKAALQVLAPKSIGLPLPTRKANPGWHEFPVQNGLNKLSLIAARMDGQVFDVEQSKWVTSIEGGMDGLRSQLVMALQSMGSGITNALEGAGKSLYFTLESRKQDMEPKEEKAPEDENKGDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSP4</accession>
    <name>A0A8G1VSP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_494856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521077.1">
        <property type="nucleotide sequence ID" value="XM_025663877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSP4"/>
    <dbReference type="GeneID" id="37167279"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034963303" description="Glycosyltransferase 61 catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="2">
        <location>
            <begin position="192"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="447" mass="51267" checksum="DAE51A7C5049640A" modified="2022-01-19" version="1">MRRILLSLLLSLSLLFIFYKTKHIGDYTIRVATPGLNPGKHITVSRTKSDRFRPLRLTECTDSTPGYYAPCMARTLPNVVSAEELIYPAYTISPPIFATSRPHDAERWWNTTWMMWERAYEMKGRVRYPEKHGQIYVFENVTLSASTPFDKWIMQACVSGLATTSHVVPSSEEPTHDSVLLANFPDSWSMQHFLDRGMRAVAQSRDHQTQYVATGREGHRSVEEFWSYLGYPADRVLHGDTTFVASQLIWSCRAPLIHPWLTQRSLSLLSPDSLQPVEKTNRKLILYMTRSNGLILNAGREVLNEDILLANIQSLLNKRGKREELKIFNHEDFPSTDALMRYVHQNVKAVIGPHGSALHNHFWAADDTLLIEFMPTSRPDFAFYEAASMRDQPYAVLMIDPVDDQHNMEVDVPAVIEILSERLDQPLEMSERLKVAYDWEAEELGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QPT1</accession>
    <name>A0A8G1QPT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_338417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825089">
        <property type="protein sequence ID" value="RAH52001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509923.1">
        <property type="nucleotide sequence ID" value="XM_025655454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QPT1"/>
    <dbReference type="GeneID" id="37158856"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="44036" checksum="57E6BE9445747B9E" modified="2022-01-19" version="1" fragment="single">DRPEALKMIKQLCEEPDKLDEWEEAQFPAPVGALAGIVYTVNLDAGTLVVSYLDFPDNDPQTVTDWYDLHTVREASSLSAAGLREELKELPTHAPEEIMNNGLAQPPLEPLHLRLDIPTFLNELQARLFIDLMWAWRWHICDSITMRYDSPALNYFCIAILRLAAWDFEVSFDTDVDLPVTDYPGVPWSCPKGDIYWFHEFLVVLHNNLEDQSMIRSAVQKAEQYLEKTASQSHHTLLIIISTCHVVFAEISDDTIRASSPSMLVSDMSSGRWPAGFRALCQILTTNCWGQSKMHRETWKPHLPAEIVQLILQHLEPRDAVAFAQASFIAEKWYYASVHQFTGLVVQGSRLLIPCCGKRSGLEQSGVMCSVCYSWQHTGCLDQANLPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQV2</accession>
    <name>A0A8G1QQV2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_454385</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="KZ825090">
        <property type="protein sequence ID" value="RAH51939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509861.1">
        <property type="nucleotide sequence ID" value="XM_025661275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQV2"/>
    <dbReference type="GeneID" id="37164677"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="50"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH51939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="385" mass="42060" checksum="007ACCF27D6EAF78" modified="2022-01-19" version="1">MFSLRTAQPAQSLLRRVAAPTSFRSSIPARSFASVQSDIFKPTKYGGKYTVTLIPGDGIGAEVAESVKTIFKADNVPIEWEQVDVSGVDTGNKHSEELFKESIASLRRNKLGLKGILFTPVERSGHQSFNVALRQELDIFASIVLIKNIPGYKTRHENVDLCIIRENTEGEYSGLEHQSVQGVVESLKIITRAKSERIAKFAFGFALANNRKKVTCIHKANIMKLADGLFRSTFHKVAENYPTLEVNDMIVDNASMQAVSRPQQFDVMVMPNLYGGILSNIGSALVGGPGVVPGCNMGRDVAVFEPGCRHVGLDIKGKDQANPSAMILSGSMLLRHLGLDDHANRISKAVYDVIGEGKTRTRDMGGQATTHEFTRAVLDKMEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRA9</accession>
    <name>A0A8G1QRA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_208853</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510101.1">
        <property type="nucleotide sequence ID" value="XM_025654601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRA9"/>
    <dbReference type="GeneID" id="37158003"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="524" mass="59050" checksum="754CA2D3C0FAE7D3" modified="2022-01-19" version="1">MVYGGKPSTGCQNCRKRRIKCDETRPHCRACVRTGRTCPGYPHPFDVMLRDQVAFHRKKRDTSSRVSSPKMRVESVRSSPAPVSSSDALISTNFSADLPQTGPLLRTAQEEVPRALVLPTDDTVTAMFFNSYIYSPRDPLILRGFMDILPDVFCYTQPGSHLHVGTLAVSYFSVAAWTGNRSFLQTAQQLFVKAIAKTREALQGDITHTVDDILMTILLLSTYEEFCAIKENRHPRRTHLRGAVALVNSKRPEQRSSIISLILENAVQVQLIKSSKGLAYPTMQTPNQWPLSPAAPQSASSQLLMITSELVGLRQAWDRFNEEGTNQVQDIHDILARAYSLDANLEAWKYALPEHWKPLPAVRVPQSVREAGMYKNRCDCYTDLWMAGTWNFYRDSRIVVQNIILRCLQILPDGVMLEQIQETINLIETLALDICATVPYILGSQTMSVHFSPQKIEYPEADGRRVTTPHYPTAALVGGWMVSSHLSNLELLCLSEEMNTWIRAQKERVLQIYTFGGEVSQISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRG0</accession>
    <name>A0A8G1QRG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_481829</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510375.1">
        <property type="nucleotide sequence ID" value="XM_025663077.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="37166479"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="55"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="55"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="114"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="115"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="331"/>
        </location>
    </feature>
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        <location>
            <begin position="372"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
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        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH52453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="413" mass="46842" checksum="CF47E111B0737316" modified="2022-01-19" version="1">MPRRVWSTEEDEKLIALVEQLGDKRGRDSKWTEISKNLPGRTNKDCRKRWFHSLDPKLRKGRWTKEEDEILLAAHRRLGPAWKEIALLIKGRKDDQCAKRYTDILDPSVKNRLRSWSPEEDHYLTTKVKELGHRWATISSGLPGRPPLTCRNRWRRLCKEITTMPTQPSQGQDDSTELSPSSGSGSFYPGSSSGNASSMDNGSQEDGESPDVHLDAMDMATGLSENILLSSPFDLNDAAILSMRYPDEGYMSLQYDSEMFSYPLVQNQTPESNHTRTHTGHLSSNENAEMNTIPRDSPSILSPEGRAGDRDRLMSNNSDIRGQETSPTNGLHTFNADNIRLALDSFTQSAEPDQNAIEEAAVQQVLTSAQWTSSNSRDALSRSYPTQAQEVHHHHHFHHHFHHHHYHHQTHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRQ6</accession>
    <name>A0A8G1QRQ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Proteasome regulatory particle subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_453926</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510540.1">
        <property type="nucleotide sequence ID" value="XM_025661161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRQ6"/>
    <dbReference type="GeneID" id="37164563"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH52618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="331" mass="37170" checksum="9E5B257A8A580DCF" modified="2022-01-19" version="1">MDRLHRMLQAAQGMGVGGNNGDIPNLIDNSETVHISSLALLKMLRHGRAGVPMEVMGLMLGEFVDEYTVRVVDVFAMPQSGTGVSVEAVDPVFQTKMMDMLRQTGRPETVVGWYHSHPGFGCWLSSVDINTQQSFEQLTPRAVAVVVDPIQSVKGKVVIDAFRLIQPQTVVMGQEPRQTTSNLGHLNKPSIQALIHGLNRHYYSIAIDYRKTGLEENMLMNLHKHVWTEALQMKDFHEEGEHNVERMKQLVSLAEGYEKRVKEETTLTKDQLKTRYVGKVDPKKHIEDVSQQLIEDNIVAVSRQMIDKEASVARQSNGKENGTGMEVDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRU6</accession>
    <name>A0A8G1QRU6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sulfatase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_407836</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510371.1">
        <property type="nucleotide sequence ID" value="XM_025657379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRU6"/>
    <dbReference type="GeneID" id="37160781"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF32">
        <property type="entry name" value="SULFATASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G17610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="3">
        <location>
            <begin position="447"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH52449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="864" mass="98292" checksum="2C4D0CE596D63DFF" modified="2022-01-19" version="1">MKLFNPLRRCGPALQRLRTSPGEFFDYTWEFTRRYFFTVSFIALFGAKLLHLYAHIHSLPPPKFFLWGSTFFFQDVILTLLIRFFTQKFHWRTVALLSALVIVPFSLIMSGMTAANTSFYIVTGAEIHWRQAKTFHRDAAAMRTLLQGLTGFLIVEGILLTVAWFLSAPLHRVVGGILTILGQPFKCLFRCMSRVRAFRPRSGLPEPEIYEQIGVDDYLDDKSDDGSSIHLLEPYGEVAPATRRGHSILIKLAVWVPFLSLVLLRVVRPWDPAYMFLSEALPVAPFIGGHRHSPVRAGGLPGDYEWLEGRTPLDKVPNWDWLPKGGLPGFEDWTRTDVPRLHYNPESDPLHVPNLQNPVLDSLQEVLSSGNVNIKHVILIKLESTRSDVFPLRKDAFMWNRIAKTYSDKKIPDDVQKLVANLTRTSEFLTGFDAGFGHDNEHDYGRRSYGGISARNAFTTGTYTLKSLVGTVCGVTPLVADFNREYNHHIYQPCMPHILDALNHQDDVDTNPTTDQSDYRTWPWHSAWMQSVTEGYDNQDKLTPKLGFHDVVTKESLEQANATHSASSSKEVNYYGYPDMVLGDYVRDALDDAEHNHRRLFLTHLTGTTHHPWGMPDNAYEEMVSSKNTNSNEDINKYLNTIGYIDDWLQEIIDILTEKGVINETLLVMAGDHGLSLPNDGGVTPYDNPHIGSFHIPMVFAHPHLPSIEVNTPVITQQVVPTILDLLIQSSSLGPNSTHTAQDLLSIYEGQSMIRELVPEMDGRQNWQFTVMNTGGSWLAVRSAAHPEYRLVIPLVDDVEWRFTNVGQDPEEQHPVTEFNLVDLAKRLEKEHGSDAVDWVRDAAHVAEWWVMENWHLYQYHPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRZ4</accession>
    <name>A0A8G1QRZ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_382172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511138.1">
        <property type="nucleotide sequence ID" value="XM_025656458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRZ4"/>
    <dbReference type="GeneID" id="37159860"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="449" mass="49158" checksum="02EA992C3F7368B6" modified="2022-01-19" version="1">MATTPPPPSTLRIPPTPRLGAKYDDYEPYSTRYSARLASQRAARDRESRTTPPPTFPSSKTTANKYDMDESDTLSPPGSAQTSPRKLKSARATGLFATHSLGGPSGTHDSDPFGAEPSSLRHQSRSLRPTMTEGMLPTPAKTPRKKAVADVGNTARVLFPPPPSARKKTKKHTGFSLDSFCEDNAQGGSEIQIYTDSRDRIPEVDESEDNPFYNKPTVSNTTTRASRRKESRRDKEIDDSLNREDGMLYVFRGKKMFRKFTDDAESDLDDDDDDLGLLAARPDLIDSSIHNVRPLTRSSIKPRVLFPTAKSQTPQESHSSDVDEEAATDIEDHLLHDEVEEDEDPAVDVEMQQRPVTPPPQSSVATPASPGATVRSLRSRSKRDGPEHSETPTASETKKKRISPFDGWLRKKTAPALTGTKAKKRDAEAAGSPGGPAPKKTRGNKATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS82</accession>
    <name>A0A8G1QS82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_432347</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="KZ825089">
        <property type="protein sequence ID" value="RAH51976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509898.1">
        <property type="nucleotide sequence ID" value="XM_025658377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QS82"/>
    <dbReference type="GeneID" id="37161779"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF3">
        <property type="entry name" value="BETA-GLUCOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="12">
        <location>
            <begin position="414"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH51976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="863" mass="93630" checksum="928DFB38FE566194" modified="2022-01-19" version="1">MSQEERASSHVRQLLQSLTLEEKVALLAGKNMWETVNIDRLHIPSLKMTDGPAGARGSKWTYGSLTTWIPCGISLAATFDPAMLEQVGRVLGQEARRKGCQVLLAPTMNLSRSPLGGRNFESYGEDPYLVGVTATAMIRGIQAQGVGACMKHFILNDTETRRFNVDQTIDERTLREVYMKPFTMVLDDPASTPWTAMVSYPKINGLHADISPHILPRLLRQELQFDRLVMSDWGGLNSTADSLRATTDLEMPGPAVRRGERLLAAIRAGEVEVAAHVDPSVRRFLQLLECTGLLGDATEATEHSEAATDDPIFHRIARDAAQSGLVLLKNDKAILPLKPTTLQRVAIIGPNARQPTAGGAGSAAVNPFYVSTPEACLRDALHAANAELQVSYEQGIPSSLRPPLLGKLLTVPDGSRSGWQVSFFEGHALEGPVVASSMWDDSLIYLFSDGDVPAVLDDRPYSYRATGVVTPQESGRYTWSLANTGKAKLFVDDELLIDNTEWTGLTGGFLGCSSADKTASVYLEAGRAYQLRVDNVVTLPVVKAFDNTLFPRISEIRVGLALEQDEQEMLAQAVAAARQADVAVVVVGHNKDSEGEGGDRATMQLPGRTDEMVSAVCAANPNTVVVVQSASAVAMPWVDAASGLVMAWYQGQENGHALAAALLGDCDFSGRLPITFPRRLEEHGSNAWFPGEAAQDRNTFGEGVRVGYRHFDAQGIPALWPFGFGLSYTRFQLTDIRVCGRVEGRSRESQFALIQARVCNVGGRDGQEVVQVYVAPSAQIREAGEMSFPKTLAGFCKIAVPAGVSREVSIPIRGSELSWYDARVAQWRLDAGKYACWVGRSSSQIDAELEIEVAEGDDIDMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSM1</accession>
    <name>A0A8G1QSM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_382589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511035.1">
        <property type="nucleotide sequence ID" value="XM_025656472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSM1"/>
    <dbReference type="GeneID" id="37159874"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="814" mass="93261" checksum="3D1F4E6514C232E6" modified="2022-01-19" version="1">MEQGIKEAAQQCVDLFTQCLENPPLMENEWAENRLADMNLWISGTGACARGRASLDSRLASRPEAHDVIVNLLRLLSTMIDECLKRSKAQDLSHIFHNEEDPTFSEHEGQGRSFSPWSDDSSSDEQSTDRHESRNPSGNLLYESMYDIESMMDQLSRVAVAIRRSGRRSRLQKADQLFNASEYQELEGHLVGMLLCQLNGRIQARDPSQLDEVQLRLVHCNLKRRNRFLYSQRHAMGLNAGYVRRTPVPKPAGSAQKEIPQEKPSWESSNNSPMHANNTVITGTSASRLSDGFQLPQPGHTLHQIDHAKSVTLSAVSNTALEVDYPRPPQLKDDARLFRCPCCCEALPAQMTDEIRWSRKHIEDDLSPYTCVLASCDQPYVLFNTKDSWRQHMLKDHSSMTYWTCFACGDGSQFSNREAFVQHTESFHAATVPLAHIPVLVELSKKTIPSEIRHCPLCNWPEDDEVEVEKDALFNRITKEVHSFSLRALPWADDNGQESIENIHNSSEKVYDWLSKNNIQKEPSIERPPCKERSLYDDYFQQNSYFACSSEVSSSFELNSDRSRQMELDKLRKADQIKSQGQKGGAYAKSERHSRTPSTHGDDGERVEEPKKPMESRKIELREEHHDTRQTSSEPSTIICPQNLKDCWSEHAYFWGPSPDSRTEVDVLFDINVTANFMSLRAAQELEIPFQSIPAKVLAPLPFDAGNQTSLMTEFQVEVNWRFAWHDAVYTSKFFVVDTEMYNVVIGRDDDSKLELNDLRRRKSEEETSEEETVYIMIKRPLKREVKQEDVPVRPDNRRSLGARLRSLFERKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT31</accession>
    <name>A0A8G1QT31_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_329764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510239.1">
        <property type="nucleotide sequence ID" value="XM_025655435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT31"/>
    <dbReference type="GeneID" id="37158837"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15038" checksum="0A0F6F1761BDC6E7" modified="2022-01-19" version="1" fragment="single">VIKRSNLVPRSKALVADLLVQLYFSGVQREVPLIDQAEFLIEFYSYCLVDTPRYPSFKWPTIINLILAIGARYGSSNLGHPLTDSDMHEVYFTHARVLGLSESLMFNHSDLMNVQIEGLTCFYLLIVGEINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT54</accession>
    <name>A0A8G1QT54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_504010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511738.1">
        <property type="nucleotide sequence ID" value="XM_025664275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT54"/>
    <dbReference type="GeneID" id="37167677"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="54" mass="6178" checksum="61F4B8896E6337B8" modified="2022-01-19" version="1">MLVWQRLVLDVAVFLIGAATNWARHWSKMRNVALPSWAPAFLQMVAALTRSVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QU44</accession>
    <name>A0A8G1QU44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_407033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510888.1">
        <property type="nucleotide sequence ID" value="XM_025657351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QU44"/>
    <dbReference type="GeneID" id="37160753"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF54">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="131"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="217" mass="25578" checksum="9183694C5088D521" modified="2022-01-19" version="1">MTHENESVRLTPSIIPDLPNYDVKESSFFKRWEQLPTPEEVQAQAKAQHLAGINICDRLRQLEQDPEDTFVGNIAQKPIYDRNFSINHLHEAGPFPTVRQFHDWFRFLPRRRRRMSDPYSVPIEPYRYGLPDHCAIKFTHGDLHRSNILITSSPPYRVMAIIDWEQSGWLPAYWEVRKAQMSAWNGDEWASDYLPTILDGFEYTVDSWWWYIAALGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVA4</accession>
    <name>A0A8G1QVA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation repressor/antiviral protein Ski3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_141394</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512134.1">
        <property type="nucleotide sequence ID" value="XM_025654077.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37157479"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040962">
        <property type="entry name" value="TPR_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18833">
        <property type="entry name" value="TPR_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="448"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="644"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="718"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="978"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH54212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1416" mass="159254" checksum="37BDBFEC53C5A221" modified="2022-01-19" version="1">MSSKSALKAVRTALDAKDFELAAEKAKAIVQQDPQIYHANVFLGLALDKLNKNTEAERAYLSAIRVKENDKTAWQGLINLFEKQGAHKLDTYRDAVLRLGQVYAESDDKNRCQDLVDKYVGFAKKNGSRSQYKKALELHLPSCPLYDFLEGRVPHPSHTYLRLIEMTEAEEKEFINREIGERRTRLGAKIDQVTLEVKREAFKRSELEELYRGIVNWSHDDEVRRTYEEKLLQRANDILSVLPANEKDAKRAEVFQAAHDMVIIKHPYELAWKIVLEWQDIQNFSEWDRNFLDDFIEFFPEDGLSKLLKGFLASDLSPFPKDKEPKEAAKKDEETENNNGESNELGVQDNLLLIVEGLEGSSASIVAHRVVAELYLSLEEYDSTVDVCRKGLRNVQDLVRRTGISLQNTTDALNIMLANSLIYYQSPRHHPEAKRIFEEILGREPKSTSCLLGIGLILKVDEDYPEAVNFLERALERDPTNIKVRGELSWCRALNGDIASGLEGLQDVLEELQEAESDNREFKAEILYRVGYCQWENDPSPAARKDRTGAYASFLASIQSNMNFAPAYTSLGLYYADYKKDKTRARRCFHKAFELSASEIEAAERLAKTFADQREWDLVEAVSQRVVDSGKAKPAPGSKRKGYSWPYAALGTVQINKQQYPKSIVSFQAALRISPNDYHSWVGLGESYHHSGRFIAATKAFEHAQQLEDNLSDKEQIWFARYMLANVKRELGEYEDAIARYENVLQVRPNEFGVAIALLQTLTESSWKSLDQGLYNDCIELARKALLVAKSLALERVDVFNLWKGIGDACTLFSYVQSKTGRLPVDELRDLLETQLEPTALDILTEVDNVGHDCLSSLTADDETANRTSQCLYAAILAYKRAIQVSLRDSHAQAVAWYNLGWAEYRAYRCLQTILNTENKKQSRKLLKAAMRCFKRAIELEAGNSEFWNALGVVTTSMSPKVAQHAFVRSLHLNDRSAQVWTNLGTLYLIHNDIQLANEAFTRAQSTDPDYSPAWVGQGFLALLFGDPQEARGLFEHAFDISTSSTRLSKKQYTMSLFDHLLSDSSLSNEISQLIQPFFALHQLSSQDPSDLPFVHLSALLAERIGEHTDAEASLRLVCAGMESEYEVTESASSLSRYAQANADIARVLLARHDFEEAAEKAETALMLSGEEDAEKFDPETNRKLRLSAHLTAGLAHYYMKSMDNAIDMFRDALQEADNAPEVVCLLAQVLWAKGGEEERAVARQQLFDCVEENPDHIGAVTLLGAIALLDADADAIDAVESDLQNMITRDDIEIHERGKLIKLLTAISTLGFTDNSGVPEDVRRVGEATAAVMRSPYEPQGWVELASTTQELYPAEMATKRAARSVPPRSNLEAIDLSAAYAQTGKASDALRAIMVAPWKQTGWEELNHAVSTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVC7</accession>
    <name>A0A8G1QVC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Multicopper oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_427299</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512255.1">
        <property type="nucleotide sequence ID" value="XM_025658148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVC7"/>
    <dbReference type="GeneID" id="37161550"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF145">
        <property type="entry name" value="LCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035002340" description="Multicopper oxidase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="79"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="202"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="440"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH54333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="65444" checksum="0BE2C0E162F9A413" modified="2022-01-19" version="1">MYWMLHVWALTTGLTAALTQYNTNGRSKWGTLPSPTLPRFLRDTHGANPPWGNTYPGGNPPDTGVTRHYNFTITRGFKAPDGYNKSVILINDQFPGPLIEANWGDMIEVTVTNDISTVEEGLTLHWHGLSMKKTPWYDGVPGYTQCPIAPGKTFTYIFQADQFGSSWYHSHYSAQYDDGLYGPMVIYGPVQAEVNYDYDLGPIMLSDYYHDNYYDVLVEGFKRPTVLVPIDNNLINGKGTFDCDSTLTNKCLPGAGLSKFQVKSGKSYRLRLVNTGALASQKFSIDNHKLTVIANDFVPVKPYLTDVVTLGVGQRTDVIVEATGSASDSVWMRSDIDILCLNETSTVYNVSAAVYYESANTSALPTTRGTPWKSNHCQNDPLETTVPYYPLAPPSTPETVQTVNITLGYNETGFLLFFVDGSSFRSNYNEPVLLMTHENTSQVYPAERNIYNFGSNSSVRIVLVNTFAMQHPIHLHGHNFWVLAEGMGTWNGSITNPSNPQRRDTQIIQAGTVDEPGYLVLEWEQNNPGVWPMHCHMSNHASAGLVLSILERPDDIGKLTIPATLSKTCRDWDQFSDANYVDEIDSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVQ8</accession>
    <name>A0A8G1QVQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_454191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510222.1">
        <property type="nucleotide sequence ID" value="XM_025661220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVQ8"/>
    <dbReference type="GeneID" id="37164622"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH52300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="388" mass="43396" checksum="922388D46BDFD46A" modified="2022-01-19" version="1">MELENKQLLGDLCDALHGCPDGATISTATIYPLLERTQSSIILGLHYGLRILHPEDELLQEIIGIQAQVTHLAANPGLPDLIPTLRQLPGFLSPWKRAADELFATQSELYLRLFHRGRDSDSWNATKQALATAEKYTAVPDLDLAFTLATSIQGGMETSPRQMLWLFIAMLHRPIVLSRAHAVLDAVVGRGRAPRFSDRPKLVYIDAIAHELFRWRPISPGSIPRRADRDDELQGVKISQGVTVMANAWAVGRDAQIFDSALGDLHDFVPDRWLLHYNPDNAEAQLRSDLPLPVFGQGRRICQGKRIATDGAFLQVANLLWAFDIMPVEGEEMDPWAMTVVGFMTMPKELRMRLKPRGDWMMEAIKRGPKIAAEDLDQMIGSVNDVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVY2</accession>
    <name>A0A8G1QVY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_381497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511531.1">
        <property type="nucleotide sequence ID" value="XM_025656422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVY2"/>
    <dbReference type="GeneID" id="37159824"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034443">
        <property type="entry name" value="PB1A10.08"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="499" mass="55750" checksum="96B5CBAF3877CE62" modified="2022-01-19" version="1">MMVPRAYLFSSLPPSPKTSLRQHGERTPVTKSSLDLLPVQDFASLEFPSESSPQTMHTSPVVIPPKRAPRVTSVHSQTAKKGPATPKKSRTVSHKSSSATLTDRSVPSSIASILEATAIPVPRRGWTVRESRNRRKLPRVDHVQQFSKLLMDGVGDNSMESTGNTVLDLLLSPPDEVDKSTVGSDCDSEAPSFSACSMSLESTPSLERDYDSPSSLPAPSTPSSQRSPLERKFHRQSPCENCIFDHPLLENEVSDTEEDFVEQASLPDLTPKSPTPSRTFPRLGSTFKSNLTASLRAIKSAAQSVSAFATPSVQPDDFLTRSLFTITPEMTDDRRPPPMNEPPSPALRRYLNPITVSPAEMYAYQEYPHESLDSPNCPVSVQMQTYHRSGRRGSRRSGFHLARSEGRDRQLLPFDPEIPPMSRQREPRENSDFLRMVVLEMNMRRSGKLRDDVPTRARIWLPPRKGSQGRYVRYDYYEDEDEDENAVPSRWVGISVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVZ5</accession>
    <name>A0A8G1QVZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_149447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH54001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511923.1">
        <property type="nucleotide sequence ID" value="XM_025654136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVZ5"/>
    <dbReference type="GeneID" id="37157538"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056867">
        <property type="entry name" value="LRR_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24969">
        <property type="entry name" value="LRR_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="525" mass="61655" checksum="77060F72070EEA89" modified="2022-01-19" version="1">MRLDDLPGELILQIVTLLTRQDYAQLVLVCKDWYSLFIHHLYQHVVLPLNDYIDANYGRFRWSEYLPVRRFTIALLENPTLAPLIRSLELYPSYGEEKWKHRPPLKPPGEEKFLPFMLPFGDAKRKYRRRFRAWRQDLKDDLEREIWIKAQRYEDAWLALLMVQVKNLERFVIELPEEWDQYCILEDNMLVKCSVHFERVIHWASNPKLGILTHLKHVLLADGPNLREWRHTESAIPLKRLIPYLRIPSLRKLYVHNACDRTQFDMPSDLVLPLTHLDLLASTDGLPNLSRLLERCPKLQSFTLELGDWGDNHRHDYLDHSHLYQPLQQSQSSLHHLNLTFLSDLTEQDAENPTPIFFGRLTGFPNLQTVHIRWGNLLPFVGKGSYNPSIPLREVLPRSLQHLYIDDCLIQSSWALCCELENLVVHLSETVPVLKTLYLRYAVREQAPGQGFIKCTLGHWSNYRMMEADPIIDARLLELQGRFRASGVEFRIIGPGAMAVSFPQEGAIRKKWPRRKSRRIMRFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWF1</accession>
    <name>A0A8G1QWF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_452617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512178.1">
        <property type="nucleotide sequence ID" value="XM_025660863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWF1"/>
    <dbReference type="GeneID" id="37164265"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037647">
        <property type="entry name" value="HIRIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410:SF2">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="362" mass="40599" checksum="B6A41DB4948C7701" modified="2022-01-19" version="1">MAPRYALSSSEPESEAGSASGRPADDVLEKALRDAVTQVYKSGKMEELTVKRVRLAAEKELQLEEGFYKTQGDWKTRSEQIIKDQVEEEDKATQEPVPDDEEEAASSASEDAKPTKRARPEKPSTSRKRHKKSASESDGGDAANGSPDEDEDKVEKVPKKQTKATLKKQQSPKTSEDYVQDSDEEEGAKPEKAEETPKDDSESELSVVLDEEPKPKPNRKRQKSAEAPPRKGRKQTTAKGKDADIDPNQAEIKRLQGWLLKCGIRKMWARELAPYDTSKAKINHLKGMLKDAGMEGRYSVEKANRIREERELKADLEMVQEGAKRWGKESGSENSDDSRPKRRLNRGRKSLAFLESEGEETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWL5</accession>
    <name>A0A8G1QWL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_87117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512839.1">
        <property type="nucleotide sequence ID" value="XM_025665748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWL5"/>
    <dbReference type="GeneID" id="37169150"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="84" mass="9356" checksum="50132872DFBDFAC7" modified="2022-01-19" version="1">MRQKHVCTYDSQEKSRLKQGTSCPKDPGSLICSMPLSPLSPLMGAGPWLLSRRWRVGTTSSSVVLSIWGLSRTVDGRPWFYKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWY0</accession>
    <name>A0A8G1QWY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_452896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511607.1">
        <property type="nucleotide sequence ID" value="XM_025660931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWY0"/>
    <dbReference type="GeneID" id="37164333"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="61" mass="7001" checksum="71DD499AE166EAB7" modified="2022-01-19" version="1">MDSPSSLSLNVQDGVHRPSSPNNFKSRFRKHLDLWKAGLAAKEHWDDEYNFQPGRYAGQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXX7</accession>
    <name>A0A8G1QXX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_451793</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512834.1">
        <property type="nucleotide sequence ID" value="XM_025660674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXX7"/>
    <dbReference type="GeneID" id="37164076"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH54912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="222" mass="24868" checksum="75ABD015DC501563" modified="2022-01-19" version="1">MWSWFGGSAAQKRKDAPKNAILMLREQLDMLQKREKHLENLMEEQDAIARKNVTSNKAAAKNALRRKKVHEKNLEQTTAQIVQLEQQIYSIEAANINQETLKAMEAAGAAMAKIHGSMTIDKVDETMDTLREQHQLSTEIATAITSTSLVDQPDEADLEEELEGLEQEAMDERMLNTGTVPVADQLNRLPPAANGEIKSKPQTEEEDEEAELEKLRAEMAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY39</accession>
    <name>A0A8G1QY39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_441023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513048.1">
        <property type="nucleotide sequence ID" value="XM_025658793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QY39"/>
    <dbReference type="GeneID" id="37162195"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="113" mass="12561" checksum="8FA556D4DC545AAC" modified="2022-01-19" version="1" fragment="single">NWNSLSSEDRKKRERSMIKLGLPIPGKDFELPVRDCEPPITEPEPEPEPEPEPAPMSSSSSGSWDMPVVSDDRLTEAPPPPEAEPEAETEPVHMSNSSFGSWDTPVSRHARWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYH0</accession>
    <name>A0A8G1QYH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,3-beta-D-glucan-UDP glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_489884</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513814.1">
        <property type="nucleotide sequence ID" value="XM_025663632.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37167034"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="523"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="590"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="649"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1329"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1378"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1494"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1587"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1629"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1665"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1696"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1822"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="13">
        <location>
            <begin position="330"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="60"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH55892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1896" mass="216845" checksum="9FD474EDB1D8A07F" modified="2022-01-19" version="1">MSGYPAGHYEDGYGHQEHGDAYYQDEHGQAYYDPNDYGDSYYDRGNYYNAEGGQAYGQEGGYYDAGHQDDYYGDQYYDQGNGAPRGRRRGDSEEDSETFSDFTMRSETARAADMDYYGRGDERYNSYADSQYAGRGYNGYRPPSSQVSYGANRSSGASTPVYGMDYGNALPGGPRSREPYPAWASDGQVPVSKEEIEDIFIDLVNKFGFQRDSMRNMYDHLMTQLDSRASRMTPNQALLSLHADYIGGDNANYRRWYFAAHLDLDDAVGFANMKLGKADRKTRKARKAAKAAAQQNPENVEENLEAMEGDNSLEAAVYRWKTRMNRMSPHDRVRQLALYMLCWGEANQVRYMPECICFIFKCADDYYSSPECQSRVEPVEEFTYLNEIITPLYQFCRDQGYEISDGKYVRRERDHDKIIGYDDMNQLFWYPEGIERISFEDKTRLVDVPPAERWTKLKDVDWKKAFFKTYRETRSWFHMITNFNRIWVIHLGAFWFFTAYNAPTLYTKNYQQQLDNKPAGSKYWSAVGFGGALVGFIQICATLCEWMYVPRRWAGAQHLSKRLMFLIAVFIVNLAPGVVVFGFNNVLSETICLIIGIVHFFIALATFFFFSVMPLGGLFGSYLKKHGRQYVASQTFTASYPRLNGNDMWMSYGLWICVFGAKLVESYFFLTLSLKDPMRILSPMRIHQCAGVTYIPNVLCHAQPQILLGLMMFMDLTLFFLDSYLWYVICNTIFSVARSFYLGVSIWSPWRNIFSRLPKRIYSKVLATTDMEIKYKPKVLISQVWNAIIISMYREHLLAIDHVQKLLYHQVPSEQEGKRTLRAPTFFVSQEDQSFKTEFFPAGSEAERRISFFAQSVATPMPEPLPVDNMPTFTVLIPHYGEKILLSLREIIREDEPYSRVTLLEYLKQLHPHEWDCFVKDTKILADETSQFNGEPEKNEKDAQKSKIDDLPFYCIGFKSAAPEYTLRTRIWSSLRSQTLYRTISGFMNYSRAIKLLYRVENPEVVQMFGGNSEKLERELERMARRKFKICVSMQRYAKFNKEERENTEFLLRAYPDLQIAYLDEEPPANEGEEPRLYSALIDGHCELLDNGMRKPKFRIQLSGNPILGDGKSDNQNHSIIFYRGEYIQVIDANQDNYLEECLKIRSVLAEFEELTTDNVSPYTPGIASEAETPVAILGAREYIFSENVGVLGDVAASKEQTFGTLFARTLAQIGGKLHYGHPDFLNGIFMTTRGGISKAQKGLHLNEDIYAGMTALCRGGRIKHCEYFQCGKGRDLGFGSILNFTTKIGTGMGEQMLSREYYYLGTQLPLDRFLSFYYAHPGFHLNNMFIMLSVQMFMIVLINLGALKHETITCRYNSNLPITDPLRPTYCADLTPIIAWVNRCVVSIFIVFFISFVPLAVQELTERGLWRMATRLAKHFGSFSFMFEVFVCQIYANAVHQNLSFGGARYIGTGRGFATARIPFGVLYSRFAGPSIYAGARSLLMLLFATSTVWTPALIWFWVSLLALCISPFLFNPHQFAWHDFFIDYRDYIRWLSRGNSRSHASSWIAFCRLSRTRLTGYKRKLLGVPSEKGSGDVPRAKFTNIFFSEIIAPLVQVAVTLVPYLYINSRTGISNDNARASNAVVRIAIVAFGPIGVNAGVSGMFFGMACCMGPIFGMCCKKFGAVLAAIAHAIAVIVLLVIFEVMFFLESWSWPRMVLGMIAAAAIQRFIYKLIISLALTREFKHDQSNIAWWTGKWYNMGWHSLSQPGREFLCKITELGYFSGDFVLGHLILFIMLPALCIPYVDKFHSVILFWLRPSRQIRPPIYSLKQSKLRKRRVVRFAILYFTMLVLFLILLIAPLVARDEGISVNLNIMSLMQPLDTDNNDTISSYTGNGLPVGYSAWTPSAASASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYJ8</accession>
    <name>A0A8G1QYJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine hydrolase FSH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_470671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513303.1">
        <property type="nucleotide sequence ID" value="XM_025662416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYJ8"/>
    <dbReference type="GeneID" id="37165818"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024311">
        <property type="entry name" value="Lipocalin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13924">
        <property type="entry name" value="Lipocalin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin-like" evidence="3">
        <location>
            <begin position="278"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH55381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="44608" checksum="F661EC6775A9A9A8" modified="2022-01-19" version="1">MRFLCLHGIGSNAEVFNTQLSAIQAALGSQHEFVFVDGDIPSEAGPGRLTSLYSTNEAYLCTGVYGVAEGPYFSFFNLPTASQIYDAFDLIDQALEDDGPFDGIFGFSQGASVAASYLLRNQGAHLPFKCAVFFCATAPFNVESAPFRSMDDGTFRDEGTGEDITAEIAANIPDLLDRKTFPSQGKSMIRPYPSDGSIQIPLPTVHVYGRNDGYYPQSRNLVEMCQSFDREVLEHKGGHSIPWEQGMTSRIVDLLRRLVHAVDLHMGSQHDIEQTLLGSWSLLELRSQLQDGGEVFPMGKGARGILNYNPNGRMSVQLQPAVTKKVKETVNDLLAYAGRYWVETQPDGSVMVKHHLELCSWPEEDGSYQSRKVELFENQLVLSSPAHVNVEVSPLVTYVFEWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYQ9</accession>
    <name>A0A8G1QYQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Topoisomerase II associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_375096</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514010.1">
        <property type="nucleotide sequence ID" value="XM_025656153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYQ9"/>
    <dbReference type="GeneID" id="37159555"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="289"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="495"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH56088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="832" mass="92929" checksum="CD7CF08019F5847A" modified="2022-01-19" version="1">MSFFGFNTTLPRDRAPAGEQRGIFDTPDPFAEVARARLAANFRDDKDDDVIDFEDTYDGLGDQLDDDQDAFNDDTFGGGFDTGPVGKDFDFFGKTAQVADVIGEEQIRYSLQKPGAPATAPSQPAADAALPDTADQKPKRSGYEKYNDPGYIPDLQAKSSVWGMSKKPEQQFQQQLQQLQQPTPQMVAQAKKMLSLEEVEAQLRRQGPSSLPAQIPLSLPQSMPEPTQPLQRAQMPPLPEGFPQLPPEILQAQFAKGVPPALLQHQPPMVPEPYPLPPNLPIHMLQNANLPPQHMVPPQRQAMPPAAQRPQQQQPPLPQAPRGNNAQLPVITNSQQLMHLTEEQRVAYLMEDAKRAKRNHKIFLLSRGNGLMTPQDKNFITRIQLQQLVAAAGNVADSDAEAVLAEDFYYQVYSQIRGAPRQHPHQPLGHFAQTYLLQTGNRLGGHGSRRQFQSADNHMQRMQQQVQRAVEAAKQKPKNKQLIIEGSLGKISFSNAKTPKPMLNIKRPESSEGAKTVKKPHTDLSVSDRKSVLTNLESVYSTLMDMEDMERTMPPPPDENDPEAIQKHMEWRQKIRSLNQKLWRNLKVMEPIVPNTNTPHPFIAFLAYPKGKKAIPRIFRHIDQEQRVTILTMIVVHLDSLDVVRRAQPVPGETQPSLAVREAIELFSQAVMPSLLGYVNEAPFNIIIGLLGLVIAQTHVQMISRTRIGLGILTMLLSRAEIVKEAGQATERDWQQWVEKFNVLFDTLEPTFADIFPSAINAGDDMYVWQFLAAVGIGASPEQQQRLVIAVKDRVMETVTYSKTLPADMASARLGNVNLFMRAIGLDVELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZJ6</accession>
    <name>A0A8G1QZJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin 2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_451019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513689.1">
        <property type="nucleotide sequence ID" value="XM_025660500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZJ6"/>
    <dbReference type="GeneID" id="37163902"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20302">
        <property type="entry name" value="cupin_DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025979">
        <property type="entry name" value="ChrR-like_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12973">
        <property type="entry name" value="Cupin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChrR-like cupin" evidence="1">
        <location>
            <begin position="38"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="180" mass="20235" checksum="D498953AA6F76D5D" modified="2022-01-19" version="1">MTSASTTDRPKATAVPYQGAPLPNVPEDLVVPNIVNLDFEERLWVPQAPDVWFRPILFNVTQGYFVNLLRVRRSGILSRHRHTGPVHATVLKGKWHYLEHPWWATEGSHAFEPPGDIHTLEVPDGVEEMVTLFHVTGAYIYVDPVGNPLGVEDVFSKLASARAHYEKVGLGAEYVDQFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZL0</accession>
    <name>A0A8G1QZL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_426627</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512987.1">
        <property type="nucleotide sequence ID" value="XM_025658123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZL0"/>
    <dbReference type="GeneID" id="37161525"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000008">
        <property type="entry name" value="C-14 sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14 16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10 16" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH55065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="497" mass="55777" checksum="768929012A8BBF11" modified="2022-01-19" version="1">MAPKKDSKTKVRVQPVPEKRGYEFGGPLGAFGIVFGLPVLVYSFTFLCNDVSGCPAPSLLHPSTVTLDQLKAEVGWPKGGFADFYDTSVTLWVLGYYLLSLAMYVFLPGQEVEGTELACGGRLPYKFNAFLSAVLILSGCATGTYVYGADFAVWTFLWDNYLQVITANLVICTVIAIFVYAKSFTVPAPGQPNPELRQLAPGGHTGNALYDFFIGRELNPRVRLPIPFVSEASRTIDIKSWLEMRPGLLGWIILNLSNIARQYRTYGYITDSIVISTAFQAFYVLDGLYMEPALLTTMDIIMDGFGFMLSFGDLVWVPFIYNFQTRYLAVFPYELGFNGILLVLAVTAVGYSIFRGANNQKNRFRTNPNDPRVKHLKYIQTASGSKLITSGWWGSARHINYLGDWVMSWSYCLPTGIAGYAIIQSINPATGDLQKQAVQTPESRGWGMIFTYFFLVYFGTLLIHREQRDEEKCKRKYGADWDRYTSLVRSRIIPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZL3</accession>
    <name>A0A8G1QZL3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_450212</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the SPT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514740.1">
        <property type="nucleotide sequence ID" value="XM_025660324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZL3"/>
    <dbReference type="GeneID" id="37163726"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.210:FF:000005">
        <property type="entry name" value="Transcription elongation factor SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="17" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="16">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH56818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="120" mass="13280" checksum="B5E7C9CDE218BF24" modified="2022-01-19" version="1">MSFYVAPSQQRTLRACMVCSLVQLHSKFMREGCPNCDNVLGLRGNNDAIQECTSQVFEGLVTLRDPTTSWVARWQRLDSYVPGTYAVKVTGSLPDEIISSLEDSGVKYIPRDGSTGEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZP9</accession>
    <name>A0A8G1QZP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor IIIC 90kDa subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_375686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513873.1">
        <property type="nucleotide sequence ID" value="XM_025656183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZP9"/>
    <dbReference type="GeneID" id="37159585"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044230">
        <property type="entry name" value="GTF3C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024761">
        <property type="entry name" value="TFIIIC_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024764">
        <property type="entry name" value="TFIIIC_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12657">
        <property type="entry name" value="TFIIIC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12660">
        <property type="entry name" value="zf-TFIIIC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC 90kDa subunit N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC putative zinc-finger" evidence="2">
        <location>
            <begin position="614"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC putative zinc-finger" evidence="2">
        <location>
            <begin position="671"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="733" mass="80334" checksum="8A4395FF3DEB7360" modified="2022-01-19" version="1">MSGPLELPLFPSCYDCLSWSEDGELAIAAGDHVQILTPKNAAERLGHDTSQSPINNWHSVRFRVNVFTNNEWPTIYPQNRDNFSLGAEQSLSNVVALAWSPPGLAKYRRCVLAVLTSNLLLSLYEPVGSQGKWTRVAILNGALKTYFNSIVQEDGMLLRKSNIRAFAWSSPLKLPAERHITPYSVLPAESRWGFHLLSVANDANDVVVLRIHRPPTGLGAPYEAGVLSVNSFQDTDENYPMLQPSSIFSEILRSKIKILSMSWGPWFHAKESASGFLAVTHGTALKVVHLDVKVLSPPPETGSQPQSQIKAISKDITPKFYEGLGGYHFTGPLAWMNTDDSHTVCLAAGTLAGLILIKASKEGHQGINPSSGRVRLQELLFYESPENDSETEPPRHSEPISAMIVAMDSDSQAPVLYLATAGGFTAAVPFRDGDDEYPIFAVPWKDQLDDVRERYDFDRDLGGLAVARAWGMASCKGMIAAGITVHPGDMIEYRTAAEERLTIIMSTTDGSQSDGLESRSVSDTSPEYLRQQREAALGYILHFEDNNENRQPLSLGVLYATACCTIIESKNEALLSQAHKVLVRLATITGVDLNDELSKCTASRTTIAPKPAEMLDGPGGQMFERCEICSAGIAWYSTEEAQCATGHIFGMFDAVLKVLQKHIMLTILPIIVRCSLTSLAIQDPGSSKVCSSCGKEYLDEDSIEPSESDVSYTCRTLFDAFDTCVYCNGKYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZQ2</accession>
    <name>A0A8G1QZQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_53104</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="14"/>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514459.1">
        <property type="nucleotide sequence ID" value="XM_025665454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZQ2"/>
    <dbReference type="GeneID" id="37168856"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000044">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 14 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="726"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="323"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="393"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="457"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH56537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="775" mass="88294" checksum="E7E807583C946DE2" modified="2022-01-19" version="1">MSSSPSPSLRKRGGKKESTPVPADKFSSPLSKATAPRSEWDYWLAISILTVLAFVTRFYKISYPNEVVFDEVHFGKFASYYLQRTYFFDVHPPFGKLLFAFMGWLVGYDGHFLFDNIGDSYIEHQVPYVALRAMPAALGALTVPVVFLIMWESGYSLPACVLSAGLVLFDNAHVGEDRLILLDASLVLTMALSILCYVRFYKLRHEPFGRKWWKWLLLTGVSLSCVISTKYVGVFTFVTIGSAVMVDLWNLLDIRRRGGALTMFQWGQHFVARAFALIIVPFFFYLFWFQVHFAILTRSGPGDDFMTPEFQETLSDNVLSAQSVGIEYYDTITMKHKDTKVYLHSHLERYPLRYDDGRISSQGQQVTGYPYNDTNNQWQIIPTVPLDVTDTSGHKVRNGDVVQLRHMGTDTILLTHDVASPYYPTNQEFTTVSHEIANGDRHNDTLFEIKIENGKPGQEFRTLSSHFKLIHMPTRVAMWTHTTPLPDWAFKQAEINGNKNILQTSNLWFVESIESLEEDSPRLVKEERQVKHLPFFRKYLELQRAMFFHNNALTSSHPYASEPFQWPFLLRGVSFWTKNDTREQIYFLGNPVGWWIASSLLAVFAGVIGADQLSLRRGVDAVEEIWGQGSRSRLYNSMGFLFLCWAAHYFPFWLMGRQRFLHHYLPAHLASALVAGALIEFIFNLEPLSVIQRVRSEDDPSGKAKASASVGRFVTAKERMGTKSLIAGWAATLVILAGTIYGFVFYAPLTYGTPGLDVPGILARKWLGYDLHFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R031</accession>
    <name>A0A8G1R031_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cholesterol oxidase</fullName>
            <ecNumber evidence="13">1.1.3.6</ecNumber>
            <ecNumber evidence="11">5.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cholesterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO85DRAFT_379409</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid metabolism; cholesterol degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.6" evidence="13"/>
    <dbReference type="EC" id="5.3.3.1" evidence="11"/>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512397.1">
        <property type="nucleotide sequence ID" value="XM_025656339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R031"/>
    <dbReference type="GeneID" id="37159741"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016995">
        <property type="term" value="F:cholesterol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052542">
        <property type="entry name" value="Cholesterol_Oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47470">
        <property type="entry name" value="CHOLESTEROL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47470:SF1">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="815"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="18">
        <location>
            <begin position="100"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="19">
        <location>
            <begin position="510"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="843"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RAH54475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1219" mass="135547" checksum="1892D9702F00551A" modified="2022-01-19" version="1">MTTTEGHRPDDYPHLTSPFRSMRAQYDVVVVGSGYGAGVAASRMARAGKSVAVLELGWERRPGSFPYSLFQCLGDLNISGISRRRLPDEPTRLFQLILGDGQHALVARALGGCSLINAGVFLEADRETLQMSVWPSEIRHDMSALRPYYSRAAEMLQPSPYPEDHPRLLKLEAIQAQAEWLGREVSFYRTPLTTFFRRERNHVGVMMQENCGSGNESTGLDDGSKNTVATTYLADAWNWGAEIFCGCEVRYIEQAPNQEGYVVYFAWHGRGRSAFGEEVKTQLFWVKANELCFLGAGALGTTEILLRSKDYGLPISPMVGRNMSGNGDMLVFGYNSDSKVNGISEAASGPTNRPGPTVTGVVDRRGLSPGDALAGYVIEDGCIPKALSPLIQAMLVLQTIRFPAPLSISESISRFGETISKFKLLPFKLYKVRGAMQRTSTYLVMSHDSNELTLTLKDDRPILHGPGEGRSENFSKIRYALSYVISRAGGKIGSSLLRGTVLLGRDREEVTVHPLGGANMSSTGTGRGGVTNHLGQVYKGHGSATHEGLVCCDASVIPTALGVNPMATITALAERSIDLIAKKRQFYIDTDTPNGRLNVYSQPMVSRRVEHGFQKAAVDQAPLSIGWQFSEVLDGHMYMQSNDLDSNACETLGRSSSCTMRMFLTIEICRRIGESSDAKHGMVLTMLDTFGLQYEGICTGTVACRGLSRGPMRVVDGRIRFFVPSKKQAESTALRYSLRLLSLEGISYKLKGYKEIDSTSTISIRGMWEATTKVNVHITRDDEMKVGAGVLRISWPSFRRQMRSFRATVPFRVRLIPALVLFLAYFALQLVVVFLRPFTPAPKSRRPPHPSPGPKQQPFNTTILRTEDGVTVRLQEYEPLPNTNEAIKGEFLGSQPVLFIPGVTGNAAHSTFALPYLRYNMVEYFTARGCRCYVLTPRWGSDAKTSAQCTVYDCRLDIAAALQHILHGQKRKPYVIAHCQGSVALAMGLLDGTIKRTHILGITANAVFMTQVLAYWNSLKAATPALIRLYEFISGTHYPIGSPDGNKPIHRVLDILLRFYPVENRRDICTSTHCHRTTFAFGLCWNHNNLDANIHDNVGQFFADTHTKLLEHVTRMGTHRACLDNDLRPLLTDRNLRNLQDIPILFMSGTVNQVFKPESTLRDYEMLRRRFGEHLYRRFLVEGYGHLDPVIGKNAADDVYWRVFEHVKGCVHEQGVTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R084</accession>
    <name>A0A8G1R084_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_451102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513781.1">
        <property type="nucleotide sequence ID" value="XM_025660516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R084"/>
    <dbReference type="GeneID" id="37163918"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH55859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="57" mass="5860" checksum="D262D74BC53AD4E8" modified="2022-01-19" version="1">MVSKAASLWDYYAGPPSSACLAVACTPFGSDLVSTPSSVISTSMPGRSCHVPPSRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0M5</accession>
    <name>A0A8G1R0M5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-methionine-sterol-C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_35199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515111.1">
        <property type="nucleotide sequence ID" value="XM_025655482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0M5"/>
    <dbReference type="GeneID" id="37158884"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF4">
        <property type="entry name" value="S-ADENOSYL-METHIONINE-STEROL-C-METHYLTRANSFERAS (AFU_ORTHOLOGUE AFUA_4G09190)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="160"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH57189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="387" mass="43372" checksum="5ACD76F2E4CF2B94" modified="2022-01-19" version="1">MDTQTTVLASRQSGRSSESSSLDAVEKQKLANKELPQTRPDLHNSASPKRWKTFWKAFRYLNNLTPKQVDDFMASYVIYNLDWSDEKAMIETLGPDYQAKVGDCLKAYYGVLNHLCALGDVEKMYIPPFMSKKATVLENQLLYEESIAQDIGLSAGDHVLDLGCGRGRVAAHMTQYSGAKVTGLNIDPNQIGQAKTYNEKLGFTNNSFVVQDFNNLPLPFEDASFDAFYQIQALSLCKDLPSLFREIYRVVKPGAKISLLDWVSLPDYDPSNPEHTELMRRVKPLIGAVGTPTPESLEKALTDAGFSVVRSDNASVGGLQAPLIDKVDFYFRSMRQVILGLVKTHVLPRHFKTLINRLCLDGEAFIKMDTMRLVTTSYRIIAQKPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1H0</accession>
    <name>A0A8G1R1H0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_52336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514441.1">
        <property type="nucleotide sequence ID" value="XM_025665342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1H0"/>
    <dbReference type="GeneID" id="37168744"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH56519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="177" mass="20231" checksum="645A3D3BF1128B2A" modified="2022-01-19" version="1">MVSSPLRGKAQTTSFLIKAAFRLRPPTFTFFIAKLHRSLGSCATWLRLAPSRQLFAAHRSPDLGLLDSHLLAGQSDASDWRVGVLVRHFVVHISVIPFICLVCGLPPHRWEPLEDGMGLAVRSRVCWLRPNRRASCSKFKFLRREWIVVPVHRNSMNIRCSAPSWFLPRLKYSLDMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1Y4</accession>
    <name>A0A8G1R1Y4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sorbitol/xylulose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_448557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516463.1">
        <property type="nucleotide sequence ID" value="XM_025659967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1Y4"/>
    <dbReference type="GeneID" id="37163369"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF3">
        <property type="entry name" value="MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH58541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="266" mass="28393" checksum="402F58D7748FF0EF" modified="2022-01-19" version="1">MPIPVPSASSVHDLFSLKGKVVVITGASGPRGMGIEAARGCAEMGANIALTYSSRPQGGEKNAEELRNTYGVKAKAYQCNVGDWSSVKKLVDDVLAEFGQIDAFIANAGKTASSGILDGSVEDWEEVIQTDLTGTFHCAKAVGPHFKQRGTGSFIITSSMSGHIANFPQEQTSYNVAKAGCIHMARSLANEWRDFARVNSISPGYIDTGLSDFVEKKTQDLWMSMIPMGRNGDAKELKGAYVYLASDASTYTTGADLIIDGGYTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2T3</accession>
    <name>A0A8G1R2T3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_488698</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515131.1">
        <property type="nucleotide sequence ID" value="XM_025663555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2T3"/>
    <dbReference type="GeneID" id="37166957"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH57209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="710" mass="79647" checksum="1BB39EAF2EF1E1BD" modified="2022-01-19" version="1">MSARPNDIPRVANFVSAQPSPTDTPSAPPPAGMTPPPRERVPRACEHCRARKIKCNGQQPCNACARHPERCLYRTGSIRQRKNRRTKEAPRPPATLLPLPTTESPTTPSDWSHTSLSDGPAQYKRHHELRAGIGVQNPETGAFQFYGPSSGFCFIHRVYQRIKQGSSSEPLLARRSCSIPDAIHRFGLERFMFARPGDSDPRRTHFPSQMFLPRELGDQFIEAYFRIMHPQIPILIMSEIVDAWNQMWETPVRDHSVKNQDILFMVLAIGARVANLRGRQSESSVAAWADYFSSRVSEGPIFLQEPSIRGVHLMLLKSMYALQLMRQNDAYLYLGHATRTCLVLGLHRAQVTDGRDPNVHRLRLTFWTTFFCERISSLYMGRPSSLSDRQIDTAYPEDLPQNLYDDTCAPMQECAFIRAMGEISKLADRISIEIYSPASIKNPTDLDKLSQVSIECDQALQAVTPTLPSYLHFFDDTVPIGEPWQEIQRVSLGFCYYVVRMLLSRPALVLTTFFTSVQEAQSATGCTELQAYIHSSTSAARNLIHLAHDVYFRRFPEIRYDGALASFLVSATLTLLYDVLNLGTDPDRARQTFTVVEKAIKCLDEIEHTGYTSGKALSLDLMRVAKQAVQASDPVVDTNQVLMDAFPWLDNWASAPVGENPDLSMYTFPPADVAVIGSLAGNEVGWTETDGNHLWLGNGFEPNAMPGCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R363</accession>
    <name>A0A8G1R363_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">mRNA export factor MEX67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_395287</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the export of mRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516244.1">
        <property type="nucleotide sequence ID" value="XM_025656954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R363"/>
    <dbReference type="GeneID" id="37160356"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042272">
        <property type="term" value="C:nuclear RNA export factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000013">
        <property type="entry name" value="mRNA export factor mex67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000296">
        <property type="entry name" value="mRNA export factor MEX67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000018">
        <property type="entry name" value="Nuclear RNA export factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="12">
        <location>
            <begin position="420"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="13">
        <location>
            <begin position="651"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH58322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="708" mass="76341" checksum="21D422C54386F94F" modified="2022-01-19" version="1">MKGGKGSRGRSGGSDRGGIRKRGAATRVDREGDLMMDAGSARNRGKKGRGDSGRSQAANKAMDAIQKAISSNSDTQANIRQGGRGSGLEQVIVRGWKLSKAASNRDGGLESLIAFLEKKLSPPDSKAGTRARITKVCATPELAVTDINYQLRPLRCALVCRGGAFRTTIGTFLSRVEGDALIVSIRPELLERMLQLNGFSFAGAPLTTEKYDPSTGGLLDQPMLSAMAQNGGTSSAAETKAKMTTILGKRYTQQTKLLDLSKLGTDPDLLAMGIFGSTSTESKFFPALMKVWELNIDNATARREAVESVSLAHNQLANITAVTTLASTIPDLKNLDLSNNEFKDAQSLIGWRWKFRNLEFLDLSNTPFSADPTFKDTMLKWYPKLRFLNNVEVRTAEEIAAQKKTPIPVQPPHFQDDSQIAENFVRAFFAGYDNDRSGILSSVYDNHTTFTLNVNTSAPRAQQTETAPWDAYIKKSRNLLKISHLPARMSRAYTGAEKIRELWTSLPATRHPDIATHPEEWLIECYPIPGLPDISGQSSTGVGGLLIMVHGKFDEINGAKVETRSFDRTFIIGPGGGMGGIRVVSDLLCLRAYGGHEAWIPEVPPAVPQAAPPAAAAAPAAPAAPAALPVAIPGAPEGYGMPAPGKADTQVQQEQLVLQMSSNTRMTLQYSEMALSGNGWNMEAALKNFEELKAQGTLPPDAFLPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3Y3</accession>
    <name>A0A8G1R3Y3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_399591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514317.1">
        <property type="nucleotide sequence ID" value="XM_025657105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3Y3"/>
    <dbReference type="GeneID" id="37160507"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="2">
        <location>
            <begin position="84"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="1">
        <location>
            <begin position="254"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="429" mass="47868" checksum="7CC9959B14FE7473" modified="2022-01-19" version="1">MSVHQNDHVIDSDEVDRIAIAPNAPDLVSRLISKINTHGQAFMLGQSSVRAQLADAAESLLAALETPRETIHRQCFRNPSGWAAINIAMDLGIFRLLAETKRPKSIPELASATGADPVLLGRIMRHLGAIHAVVETKRGKYTTNGFSFTLAHRKYSDSILAAAGSMYPSINGIPEFLRQTGYQNPSDGRHCPLQMVYRTTDSLFEYLAHNPVIGAQFNTLMEVYHQGRASWMDPGFYPVDQLMSPSPIGEHDVLLVDVGGGRGHDISELRAKWPNLPGKLILQDQPAVLAEATNLHPSIEPMSHDFFTEQPIKGARAYFLHSILHDWPDKDCHQILEPLRAAMIPRVSRLLINDYVMPEQGAHWQATSQDINMMSILGSLERTESQWRQLLTEAGFRVVNVWTVDWWSESLIECEVVASSASETVRDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4S7</accession>
    <name>A0A8G1R4S7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA2/NAM7 helicase helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_511985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517190.1">
        <property type="nucleotide sequence ID" value="XM_025664627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4S7"/>
    <dbReference type="GeneID" id="37168029"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="181" mass="20396" checksum="7D99BC1AF40CC9CD" modified="2022-01-19" version="1">MSIDDYQARYQLCIGSTDKILLQSQPFVTGVFRPELIVIDEAARASEADLWPVFANYGPRGYLMIGDPFQLHPVVESTPQNSPLYAVSATSIFRRLHMNGMLLCMVDVQYRMASMLGDLVSQLFYQGWLCSLYPLPSALQTMSGRIADLNHALFGALPPRGDDPWQLLPFMCWKQMCIIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4S9</accession>
    <name>A0A8G1R4S9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2 type zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_370361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516181.1">
        <property type="nucleotide sequence ID" value="XM_025655957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4S9"/>
    <dbReference type="GeneID" id="37159359"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF19">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="484" mass="52576" checksum="C7A744F15708C347" modified="2022-01-19" version="1">MTESYDSDGPRTPALKPSTINYLPKVSPPPFDTGDQSPKGGLPKHDAEAQFPSSSQPNRPDIAWFETENPLHRSTPADDPYPVLPKILFAPDKSSVETKEPVDVVARKALNLISPSEPKEGGPSVGPKDPPTAYKEPRRPSIPVEEPALKEEQQQHTPPNIPHISHLFQDGKLPDPEQRLSKLLIAPSEPTAQLPALHPSATASSVNHNLPSLSTALAGVTDVPPPAGAGRLNGSSFGPLPPVSSSSPPVSRTEPVWEHQRLGQIPPPPPQVPPSPYSHLSPASSKDMSAMSSPASQQAYWRPPIKADITYLTSTYETAPQTAKSPATSYPTPTDQTPASTCDRSYNPPTHSNGAVSTGTYKCRHPGCTAAPFQTQYLLNSHANVHSQDRPHFCPIAGCPRGPGGKGFKRKNEMIRHGLVHNSPGYVCPFCPDQQHKYPRPDNLQRHVRVHHVDKSRDDPALRQVLSQRPEGSTRGRRRRNNVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5H4</accession>
    <name>A0A8G1R5H4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 finger domain protein Acr-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_475876</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518383.1">
        <property type="nucleotide sequence ID" value="XM_025662751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5H4"/>
    <dbReference type="GeneID" id="37166153"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="569"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH60461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="617" mass="68525" checksum="08695D3045E363E2" modified="2022-01-19" version="1">MSKGCYTCRRRRIICDNGLPTCRKCRDAGKECLGYQKPLVWVKGGVASRGKMMGRSFNEVMRPSDLRRGDSSPSSSSNASPPSAADSPTQSIDISLYVPPNVSGIQGIPEPIQSEDNDDQDTHVVLQRATSVSAPWGLVDPLFKDLSQLSRFYIVHFNQNLANYLTLYSETGNPYRDLIPLVGDSPLLAHVLAATGALHYAILASGDFSLTPWLSEGPPADRTLLSPEEVEKSVIASMSRRPSSKVYEHFLGLKQRALGQLSSDIRDPVLRNDNRTLAAITVLALMDAIESGDGAWKFHLEGAKKLLKGRQEQGASSPPQHLVKWLEDFAVDGILLIQLMGSTLARPGSLTKPFYTSSMGPAMLKRLEETSYVGCPAYLLEVILLIHAGLYFDPDVDPNSQPSMIFTSAFLSQDTNPLQSPGALLQHIRAFDPSAWAESMQSCYYLADLSMRTALATIFKGAVYLYASRVLSRPRPGAATIPNHFGLPSDHAEVADLIIREIALIPIDDPHFKCLIWPTFIAGAECRDPSQRPFVLNKLRALYFNITSVNVRNAAWVLSLMWQKQDQKKAEKEQQQQRPTTTTTTDNYYSHDDVNDDDDDFDWIQELDNSRIDWLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5I5</accession>
    <name>A0A8G1R5I5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_518450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517580.1">
        <property type="nucleotide sequence ID" value="XM_025664974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5I5"/>
    <dbReference type="GeneID" id="37168376"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020301">
        <property type="entry name" value="Mrx7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10906">
        <property type="entry name" value="Mrx7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="87" mass="10166" checksum="0C72122B1D800BE0" modified="2022-01-19" version="1">MFRAFLKSAFMLRPLEEWLTSRLLASRSFHKLVGGIHRKVHHLKTGVRLEEVHGPDSGKSASKLSQFFEYFKEELKDQMKGTPRNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5J6</accession>
    <name>A0A8G1R5J6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_369419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516824.1">
        <property type="nucleotide sequence ID" value="XM_025655919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5J6"/>
    <dbReference type="GeneID" id="37159321"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034151299" evidence="1">
        <location>
            <begin position="22"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="150" mass="16687" checksum="B83A754CB78CB0BB" modified="2022-01-19" version="1">MKPLQLIPTLLLSLVPTLTHASDSDDIPSGAKLCQPQGKGSCQFGVYQLYPGIDCYHQTMNSAYLFDHACNIIGHVENFTQGDAMTSQLPYTLDIENVFGYPSCYLKYEIAYSDGLYGYSMPSGGVWDDCEKGDDFLCTWYRVAFDCPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5L4</accession>
    <name>A0A8G1R5L4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AhpD-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_437174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517008.1">
        <property type="nucleotide sequence ID" value="XM_025658610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5L4"/>
    <dbReference type="GeneID" id="37162012"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF5">
        <property type="entry name" value="CARBOXYMUCONOLACTONE DECARBOXYLASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23649" checksum="61E20393C51B41D2" modified="2022-01-19" version="1">MSEINPNELEGDPYRHTCLVPYVDPDTAPPNIQERLKVLPFRRNILLTLAHSHGLFPHISGLLGACFDRNQRSIPVHEWQLIVLRVGTILQAKYEIDVNKPVAEVFGFPQEKFDAIGCCIEDVMRGQGPWSDRDRVILRMTEEQLSTYDNKPEIIEDALKSLSVGDVVEVLLIIGVYAALARVKRRSQSRRRRTDTRSKGEDQDCKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R684</accession>
    <name>A0A8G1R684_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_436408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517353.1">
        <property type="nucleotide sequence ID" value="XM_025658574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R684"/>
    <dbReference type="GeneID" id="37161976"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038732">
        <property type="entry name" value="HpyO/CreE_NAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052189">
        <property type="entry name" value="L-asp_N-monooxygenase_NS-form"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40254">
        <property type="entry name" value="BLR0577 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40254:SF1">
        <property type="entry name" value="BLR0577 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13454">
        <property type="entry name" value="NAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="802" mass="87803" checksum="8A4BFAFA51DBA395" modified="2022-01-19" version="1">MGSSLSSVATSSTEDIVIVGAGASGIAVLLRLIEHAKNGKKIPPITVVEKASPPGPGLAYSAACTGTILNMHTDTMGLYYNDPKHFTRWRSELSSGPFPSRSQYGEYLEAMWSGILSQAQQMGLEISLIQDDVLDIDRHDDGSFALTLAGGSHLSAHSVVLALGNFTSTLNTHLLDQPGFFPSPWPTSQLQSIPADAPVLIIGSRLSAVDAALYLSKNGHTGPMTFMSRSGRLAKVQGEPEPFPRRYTLHTLARELESNPAEGLVKLTTTLMDEIDGVNNGDWTWIQKHVSPKAELRADLCAAQEGNVHWQTVLRHTAPVIERYWHCLPLESQQLFMAKFFTPWMRYRHGMPVQNAQKILRLMESSQLSVVAGEAVHWDDNGGIFIAQTTAGPIEAAYVIEATGQECHLDRIPSPLVQSAVRKGLFTPHPMGGVDVDFDTLCASTPGLYTMGSLTRGTHFYVSAIDRTAAHAARIADALVGEPPARPLHIAIFLGLDVASHLMASDLVPRLLAEGHMPFLFLTPSTETPPIEAPGSWPFDLRKLAFFERELLRKHLSPRLKEYGFKGTRHMTPEQMQSTYGVFVQEIPDSKGTSVVKMLQKHFIDVGISLSCGDVLNQSVIDYFSSSSHPLLSLDGGFLSAPWGSKKVGAQFGYTLRVFRGDGELGDIIDRRTFPLGHSVAILTGVNKEYALGVQITFDAIQLVSRGKPLRDVAWDRTSHTSRHSYLTAEELLQYSHGRGIDLVDGDSVVEMLVESFAPPEKREVLRKELGEVVHECVESRLIVLSSLSGMTSELNTLLFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6N7</accession>
    <name>A0A8G1R6N7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_485342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="RAH60182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518104.1">
        <property type="nucleotide sequence ID" value="XM_025663323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6N7"/>
    <dbReference type="GeneID" id="37166725"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="120" mass="13467" checksum="C22ADC14451BC4EB" modified="2022-01-19" version="1">MAHHETDLTRTAKSKKRGASTECDRRLPEDSHVSGQPRQSYYGHNFQQSEQGLSSSFAFGDIKKQNLPDPWVKAPNPYPERTQSDYHAYKAAGRHLAAVKRDYVDTNPLSPQNASELAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6U9</accession>
    <name>A0A8G1R6U9_9EURO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_189494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6U9"/>
    <dbReference type="GeneID" id="37157822"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH61166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="112" mass="12739" checksum="A259E6CE70CB19C5" modified="2022-01-19" version="1">MRVRGSQWRYPGSCIQYYIPLTVRTTSRGKPGHLGKQWYHPSWFPSIMVLISHYCCRTPICAVSVSIVSTVLFLPINLFPDGLRRSSECWVPRLSSAVACICCRNICIPSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7U1</accession>
    <name>A0A8G1R7U1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_486920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="RAH59325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517247.1">
        <property type="nucleotide sequence ID" value="XM_025663419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7U1"/>
    <dbReference type="GeneID" id="37166821"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="84"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH59325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="26162" checksum="42BB02328CCEA3DF" modified="2022-01-19" version="1">MSVHLQLPPLDLADGITVNVTNPYSYVWNATRDKYRESGCAFELDSLDMFGILNPPVLTSVKIGVSKRQKDDPPPEFYNLYDPTSSTSSSTSSTTSMKTTSSATSAKSTSTSSSHATSTAAAKTTAASASSIPATTDNGSGLTVAQKVGIGLGIPLGVLAISTAGALGFLYRRRSQMGSGSDETPYSDQPASSGMVEAVKPPWNPRISRTETVIAELPSPSFDMEGISEEANHRPISEVMGTPRSELST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7W7</accession>
    <name>A0A8G1R7W7_9EURO</name>
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        <recommendedName>
            <fullName evidence="3">Glycoside hydrolase 131 catalytic N-terminal domain-containing protein</fullName>
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        <name evidence="4" type="ORF">BO85DRAFT_446337</name>
    </gene>
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        <lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
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                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025659481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7W7"/>
    <dbReference type="GeneID" id="37162883"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034765459" description="Glycoside hydrolase 131 catalytic N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="3">
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            <begin position="18"/>
            <end position="241"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH61164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="399" mass="41080" checksum="4B49E05F5FDABE30" modified="2022-01-19" version="1">MKGAAFLAFPASTLAGSVLWSGIFNSSYTVADFDEWSWSNQIAPWQWYIHGDGETSEYLALSSDYKNPAASDAQGLRTRLDKTSFWEGQSMQRTELIPQMSPSSSASDLGSGHLYYHFSLSASSTNPPSSSSEHQIAFFESHFTELQYQDNTLKWNAGGDTHYSVELETGKWYNFAYDIDFDNQKVGLWASNGSDALTEVVSPVSASASSNGADFHVGVLSLTGDGTEDWFWSGVYIEKGDLTKSIGDGSSASASGSESSSTTVAAATTTSATSSATSATSSATSATSSATSAVTTSAEATTAAAATPTQDVAVASSSTSAASTTSVATTSSSESTAAATPSASAPVIATPSAAPSAAAASGSAALPVPTTASEILTDVRALLTALLTRQGVHARDFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7X1</accession>
    <name>A0A8G1R7X1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Formin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_414254</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518885.1">
        <property type="nucleotide sequence ID" value="XM_025657641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7X1"/>
    <dbReference type="GeneID" id="37161043"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000027">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000032">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000033">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000034">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000078">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000090">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000013">
        <property type="entry name" value="pre-mRNA-processing protein 40A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25432">
        <property type="entry name" value="FF_PRPF40A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="9">
        <location>
            <begin position="157"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="9">
        <location>
            <begin position="226"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="9">
        <location>
            <begin position="373"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="569"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="345"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="569"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="648"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="751"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH60963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="797" mass="94206" checksum="3A6849387197BEE0" modified="2022-01-19" version="1">MNPMNGPAGAPPLWQEARNSDGRVYYYNVQTKATQWAKPIELMTPVERALANQPWKEYTAEGGRKYWYNTETKQSTWEMPDVYKSALAQAPAPQAPPVAAPTFVAGGVSSFSSYPQQRDRDDYDRGYGDRRGGYGSMDTNGIAAAPILGTQQAEPEYGSLEEAENAFMKMLKRHNVQPDWSWEQTMRETIKDPQYRALKDPRDRKAAFEKYAVEVRMQEKDRAKERFAKLRADFNTMLKRHPEIKHYSRWKTIRPIIEGETIFRSTDDENERRQLFEEYIVELKKEHIEEEAVKRKAAMDELVTILKSLDLEPYTRWSEAQAIIQSNDKVQSDDKFRTLSKSDILTAFENHIKSLERAFNDARQQQKAAKARKERHAREQFIELLKELRSQGKIKAGSKWMNIYPLIHEDPRYVGILGNSGSSPLDLFWDMVEEEERSLRGPRNDVLDVLDDKRFEVTPKTTLEEFNAAVSGDRRTANIDPEILQLIFQRIQEKAVRRSEEEKHAADRHQRRAIDSLRSRIKRLDPPVRATDTWEQVQPRIERFDEYKSLETDELRQAAFDKVIRRLKEKEEDAERDRETRDRDRGSRRDHHDRDRDHRSGPSYRGERRGTSSRLSRTPEPDAYEADRRKAQADRERSYRKASGLSPVRERREERDRDRERYRERERDRDRDRDWDRDRSARPLSHYERERREREEERERLYRTRGDPRGGRDELDYGADTRSTTSNDRRRRRDSDTESVASRSAKRYRRDSRERERSRGARRDRDRRERTPAATDDGKKEEKAVHSGSEEGEIEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8P9</accession>
    <name>A0A8G1R8P9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_391798</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with histone H3 and histone H4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ASF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518206.1">
        <property type="nucleotide sequence ID" value="XM_025656823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8P9"/>
    <dbReference type="GeneID" id="37160225"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1490:FF:000001">
        <property type="entry name" value="Histone chaperone ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017282">
        <property type="entry name" value="Hist_deposition_Asf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037759">
        <property type="entry name" value="Histone_Asf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="190"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="217"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH60284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="287" mass="32136" checksum="FD2A31D23CA528FC" modified="2022-01-19" version="1">MSVVSLLGVKIVNNPASFLDPYQFEITFECLEQLQKDLEWKLTYVGSATSSEYDQELDSLLVGPIPVGVNKFIFEADPPDLKRIPTSEILGVTVILLTCSYDGREFVRVGYYVNNEYDSEELMEQPPARPIIERIRRNILAEKPRVTRFAIKWDSEESAPAEYPPDQPEADQEGDDSAAYGAEEAELEAALFKELNDLEPKTEDQEMEGTEGPAAKEEEEEDISDAESEDIEDESDEDEEELDEEEGDDGDEDVEMGDDSEQKDESAGGASNNNPAAHQQQPELMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R953</accession>
    <name>A0A8G1R953_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endosome-associated ubiquitin isopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_238899</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518684.1">
        <property type="nucleotide sequence ID" value="XM_025654815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R953"/>
    <dbReference type="GeneID" id="37158217"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000033">
        <property type="entry name" value="AMSH-like protease sst2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000024">
        <property type="entry name" value="Endosome-associated ubiquitin isopeptidase (AmsH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="367"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="229"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="304"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH60762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="547" mass="60628" checksum="5EA1B690A2028D9E" modified="2022-01-19" version="1">MAAHLPPATGAGSPQSVESITRMAQDYEYNPSIPLRYWLRTASTLMREARIYEREKHEEQAYLLLFRHAQLVLVNLAEHPEAKDEKNRKALVEAEKEVKRNLKVLEVLKPRINKRYERYTQLMRERQARAPAAANNTPTSIQRPPQDPALAGVVEPLEAGENKDLAVQLARTELSRRATVRKAIRQAGITPEEEQTRRAAGVWGDWEHALRKDGSEDDDLSRRIQNVRIQMDDPRADHRPQVATKPMVRPSSATSSTGAYKYPSVPRQKPLEVPSAAKAEPKIVLPPKAPALPPKKASYVHELAGLEGPSPPPRPDKISSAEIPAEPPALPGKVPATDGPAASPDLDPSSYTFKPSAYLENGTPLRTLFLPPDLRKHFISLVSPNTQRNLETCGILCGTLVSNALFVSRLLIPEQTATSDTCETVNESAIFDYCDSEDLMVLGWIHTHPTQTCFMSSRDLHTHCGYQVMLPESIAIVCAPSKTPDWGVFRLTDPPGLKTVLNCTQSGLFHPHGEANIYTDALRPGHVFEAKGLEFETVDLRPKGSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9N5</accession>
    <name>A0A8G1R9N5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BO85DRAFT_185311</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="17">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518954.1">
        <property type="nucleotide sequence ID" value="XM_025654380.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37157782"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 18" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1005"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1153"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1185"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1323"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="284"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="20">
        <location>
            <begin position="383"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="1032"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="242"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1267"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1344"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
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        <location>
            <begin position="69"/>
            <end position="88"/>
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    </feature>
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        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
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        <location>
            <begin position="257"/>
            <end position="275"/>
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    </feature>
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        <location>
            <begin position="635"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1364"/>
            <end position="1384"/>
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            <begin position="1387"/>
            <end position="1399"/>
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        <location>
            <begin position="1420"/>
            <end position="1433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022967"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
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            <dbReference type="ARBA" id="ARBA00048694"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RAH61032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1433" mass="155992" checksum="50414FDC95B8CA25" modified="2022-01-19" version="1">MPDSKSDGHDARQSGSTPLRRERAPTITIDTSAVTSSTDQQEPPQQILPTPSHPSLQVSTENVDAHDMSALLSSGGVSPSSVRSFASSENRDYESRPTSPHNISSPASKMTENMSNSNYLAVPGTRSRGNSLESEDSNNSYTSSYGGDTYVPTASHGSRTDLTQNTIISDEDALKPDPGREAEFEVEDNKFAFAPGHLNKLLNPKSLGAFHALGGLRGIEKGLRTDARSGLSLDEGDLDGTVSFEDATSTQTSESLPKTASSTPTSPPRTGTGSSKHVENAFGDRSRVYGRNKLPERKAKSFLELAWIAYNDKVLILLTIAAIISLALGIYQSVTATGKEARVQWVEGVAIIVAILIVVVVGAANDWQKERQFVKLNKKKDDRLVKVVRSGKTAEISIHDILVGDVMHLEPGDLIPVDGIFITGHNVKCDESSATGESDVLRKTPAHDVYRAIEQHENVSKQDPFIVSGAKVSEGVGTFLVTAVGVNSTYGKTMMSLQDEGQTTPLQSKLNVLAEYIAKLGLASGLLLFVVLFIKFLAQLKDMGGASEKGQAFLQIFIVAVTVIVVAVPEGLPLAVTLALAFATTRMLKDNNLVRLLRACETMGNATTICSDKTGTLTENRMTAVAATLGKNLRFGDKSTETSSRPDGDRGRDPATTLSPSEFASSLSAPAKDLLIQSIVYNSTAFEGEQDGVMTFIGSKTETALLGFARTYLGLGSLSEARDNANLAQMVPFDSGRKCMAVVVKMENGKYRMLVKGASEILVARSTRIVHNATQDLSEGPMSDQDRSNLDNLINRYASHSLRTIGLVYRDFDQWPPRGAPTQEEDRSLAVFDAVFKDMILLGVFGIQDPLRPGVTESVHQCQRAGVFVRMVTGDNIMTAKAIAQECGIFTPGGIAIEGPKFRQLSSRQMTQIIPRLQVLARSSPDDKKILVTQLKKLGETVAVTGDGTNDAQALKTADVGFSMGISGTEVAKEASDIILMDDNFTSIIKAMAWGRTVNDAVKKFLQFQLTVNVTAVVLTFVSAVASGDEESVLTAVQLLWVNLIMDTFAALALATDPPSPHVLDRRPDPKSAPLINLTMWKMIIGQSIYQLVVTLVLNFAGQSIFHYKTADDLDRLETMVFNTFVWMQIFNQWNCRRLDNNFNIFEGMWRNFWFMGIQFIIIGGQILIIFVGGQAFSVKRLNGAQWGVSLVLGVISLPVAVIIRLIPDEFISRLIPRFWQRKKGPELLVSDEDRRFEWNPALEEIRDQLKFLKTVRGGRLRHLKHKLQHPEELLPRSRSGSRSRENSIPGTPVGEHSDSTPTQPPTPDSRSRRRTRSRSNSAFGPAAAMAGVVAGSIAGWSPIERAPGDGEAFKVQTDSPHGGLDKQKGIEIHPDTAADDRILGDYQTTSKTPPSQNPGLLPHFEYAPPERAPSHRSQRSTSRLSRSSQSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9Y6</accession>
    <name>A0A8G1R9Y6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="7">SDH assembly factor 2</shortName>
            <shortName evidence="7">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_456065</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SDHAF2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519920.1">
        <property type="nucleotide sequence ID" value="XM_025661424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9Y6"/>
    <dbReference type="GeneID" id="37164826"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000039">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit beta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034339532" description="Succinate dehydrogenase assembly factor 2, mitochondrial" evidence="10">
        <location>
            <begin position="19"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="31"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="544"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="592"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="634"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="677"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="721"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="821"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="262"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH61998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="849" mass="94591" checksum="5322D07561549347" modified="2022-01-19" version="1">MRSFLGLLFLLFVQLTSALKFDLSAVSGKNERCIRNFVFKDQLVVVTAIVSGNKGDGQVVNMHIKDALGNDHGRPKDIAGETRQAFTSPADTAFDVCFDNQLTTRRMSIHLDAVANPYKSIELDVDIGADARDWSSIQVQEKLKPVETDLRRIEEMVAEIVSEMEYLRAREQKLRDTNESTNERVKWFAFGTMGMLVGLGAWQVVYLRAYFRYNREKEKVPERRPLPKVDRPSLGAIVCHHEAASNKTANAILSVVRQNSVNNNDRAPSTAPEHRKNQTNKPPNPHVPNTTSTMTKDFPKVGEKPAPPEMLNSVDPNYRPADPYPGRVEHFTGGRQETGAQKPELGVGEMEGITFKVEPLRREGEDVTTMRARLLYQSRKRGILESDLLLSTFADVYLADMNKEQLQEYDRFLDENDWDIYYWATQDPPAEGTEAAVSTEAGAQDTPTETWKRTGAKSGEWAQTVGAFKAAYRPVPSRWADSNVLRLLRQHVQDNSATGFHAAKTKKTGGPGLGQSTTIAPPAFIPLSSQTPNMAEQLVLRGTLEGHNGWVTCLATSLENPNMLLSGSRDKTLIIWNLTRDEQAYGYPKRSLEGHSHIVSDCVISSDGAYALSSSWDKSLRLWELSTGETTRTFVGHTNDVLSVSFSADNRQIVSASRDRSIKLWNTLGDCKFTITDKGHTEWVSCVRFSPNPQNPVIVSAGWDKLVKVWELASCRLQTDHIGHTGYINAVTISPDGSLCASGGKDGTTMLWDLNESKHLYSLHAGDEIHALVFSPNRYWLCAATASSITIFDLEKKSKVDELKPEYVEKGKKSRDPECVSLAWSADGQTLFAGYTDHKIRAWGVMSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA47</accession>
    <name>A0A8G1RA47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_485007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519194.1">
        <property type="nucleotide sequence ID" value="XM_025663288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA47"/>
    <dbReference type="GeneID" id="37166690"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="656" mass="73497" checksum="DED6D6CAD7343A3C" modified="2022-01-19" version="1">MKLRNSIRPPERFNQDQFYSPCTKRSLRVPQNQDCIHSTPFDPNLPPAAFPTLDHPSPPSLRDKESGHWKGQEADLSKRPRGQEKDDENIENKRVRGVDSGVQTRPPASGQNCILDNGDFNPVYRRNMTILANVGRESSIERYLMDSDMDEPMNDAPDEEDIEAPSATASVRPCKWSDLSPQIQVEIIDNMLQEFDWPTTCHLLGLTAEEREETQQNIRQWDRQAKQEDIQLEDMRERQLRALLRVDNTKSGHNRVPHQGIFSKISRQVSGQLQDQIDSDISMCQASELLDAKMFLRMRGLDRKYAGEWGNGTSAWQALEDDDIEPCLDDDQRTHQPLVDCAEFDATGLSAQGDENANVPDPDDNCTIQAYEMAKYCPNSERNKYLHQFRFNKPRQCNKDSQPRHKVVYYDPRGSEPCRLSVGAEKAAHVCDTRGRIPKLVSRPWEMPLTSLSFNGPRPILGTFYNTHGNKLDARRSQNAAFVPPTRPPYGSMTDRRAGQTAFSSGPDPRHGSSATEVRKEIPLRSSSGSTYATLSESGKTSSPVIWSPKATPNTAVSTTSPDCLAADENKQSPHVTSAPQSPLEAKKVLRESAAQNSGHEVLTEDSRLGTPPKRPVESLVSKENKVHSSKKPSDGDDSSENSHDSDYDEVVLLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAB3</accession>
    <name>A0A8G1RAB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GXWXG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_507102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519378.1">
        <property type="nucleotide sequence ID" value="XM_025664386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAB3"/>
    <dbReference type="GeneID" id="37167788"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.580">
        <property type="entry name" value="GXWXG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025951">
        <property type="entry name" value="GXWXG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14231">
        <property type="entry name" value="GXWXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GXWXG" evidence="1">
        <location>
            <begin position="27"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="139" mass="15419" checksum="29EB721E41AC41ED" modified="2022-01-19" version="1">MTRSAADKYISLANALEQLDPAEVDHVYNELEPVDPNVLEGEWDMHVIDTGHPAQALAEDVLPLLSTMDFDDDAEKVHKIKFHGAPGHLVIPGDQASTRRFRYVDASTIAATNGYRAYYGNSGVLHFYLTRAEDPCYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAB5</accession>
    <name>A0A8G1RAB5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_187646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519016.1">
        <property type="nucleotide sequence ID" value="XM_025654398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAB5"/>
    <dbReference type="GeneID" id="37157800"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="81" mass="9042" checksum="597DDF0164DBB1D2" modified="2022-01-19" version="1">MSGQLFLSPLLDLSLSLSSILFPYSILPPHRSVLLSYFDLTTFPFSISCLFIIPVLSDRHYFSFLPLPCLCFAVARSLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB81</accession>
    <name>A0A8G1RB81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Nitrate reductase [NADPH]</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BO85DRAFT_446410</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion outer membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nitrate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519167.1">
        <property type="nucleotide sequence ID" value="XM_025659500.1"/>
    </dbReference>
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    <sequence length="577" mass="64796" checksum="5F9654876068D328" modified="2022-01-19" version="1">MVSPEMSSSDPNWWRDDRYAIYDLNVNSSVVYPEHKEVLDLASAGPSYNVKGYAYAGGGRRITRVEISLDKGKSWRLANISYAEDKYRDFEGDLFGGRVDMSWRETCFCWSFWSLDIAIPELENTDAILVRAMDEALSLQPRDMYWSVLGMMNNPWFRVTITKENGTLRFDHPTDPTGPGGWMERVKKAGGDLVNGNWGERHAGEEPAEPEPEKEINMKKDGVNRMIDLEEFKKNSSDEKPWFIVNGEVYDGTAFLEGHPGGAQSIISSAGIDVSEEFLAIHSETAKAMMPDYHIGTMDKASLEALKNDSAPESDEPRATFLQSKSWSKMTLVKRKDVSWDTRIFTFQLQHDKQTLGLPIGQHLMIKVADPTSKESIIRSYTPISDTNQEGTMDLLVKIYFDTPTVKGGKMTMALEKLALGSEIDCKGPTGRFEYLGNGKIMVSGKERHVSSFKMICGGTGITPIFQVLRAVIQDKQDPTSCVVLDGNRQEEDILCRDELDAYEALDSKKCKVVHTLTKAPESWTGHRGRISEDLLKEYAIPDGKSMVLICGPEAMEKSARKILLEQGWAESDLHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB83</accession>
    <name>A0A8G1RB83_9EURO</name>
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        </submittedName>
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        <name evidence="2" type="ORF">BO85DRAFT_445405</name>
    </gene>
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        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
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        </lineage>
    </organism>
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        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 112811</strain>
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    </dbReference>
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        <location>
            <begin position="116"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
    <sequence length="221" mass="23840" checksum="2E5E0459CE5D79C9" modified="2022-01-19" version="1">MFGIRSFVRQTPRWTQLRAVSTLEGHSHIYVFPRNGTNILSLLPSEPTNPDLALGVTSKLPPTPDSFKENPKFLSILQEVIAEHGYKDPEAVSQAQVMVSTAGANLMSGGVLMGGARSRRRRGEVGDSSGGASGQGGAGSAGRGGWIHLSDGRRPPEYGRIAWPEDIFGSLEVDADGKFVGGNGNYQASGTYRIVTRDGIFGLSPFLREKLVQRLRQQESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBP7</accession>
    <name>A0A8G1RBP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BO85DRAFT_356026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
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                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519706.1">
        <property type="nucleotide sequence ID" value="XM_025655491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBP7"/>
    <dbReference type="GeneID" id="37158893"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH61784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="52" mass="5739" checksum="6357CA001349A294" modified="2022-01-19" version="1" fragment="single">EQPRGVVHARPKRLSLPAATCGLLESCLYRHVYTGAGGILPLRSSFRIVIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDP6</accession>
    <name>A0A8G1RDP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_465101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521099.1">
        <property type="nucleotide sequence ID" value="XM_025662029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDP6"/>
    <dbReference type="GeneID" id="37165431"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH63177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="507" mass="57240" checksum="EBF7A8A180A5F120" modified="2022-01-19" version="1">MSDTRSSTGASLPDVSPPRNPKRRRARHNKSRKGCYTCKLRRVKCDEVRPVCGACSFRDEPCSFPPPEEHVIPTSAGRARRLASNNIGQPLRPLDLHMPPLSESAEVSHQNEGLDMPDMGLLTHFMVHVSGRMALHPERKLIWQRVIPTLAAEEEYLMHLLLALAGTHALCEAESPRANSLDPNLDPNFQKNPDENSFRDYHRILDHHQKGLEGFRHALSEATASTAEYIFCGSILIVAFAFASLRIRALGDKGMGFHNGDSAGEPWIDWLHLVRGLGAFVGEHYGVLRTSRLRTIMNYPHANEHWRDVPATSPTLVFPRLQRAPPRFIRFAQGAAQQISLLRAFANTLTQDYGISMEDTPSPDSYGSPNIQTIPELLREQISTIDRLEDMYMRTVYVFRFATSERDNPVSMDLQTDLEDAAVLSWPHCISLSFISSLQQGNDAGIFEGFSYVILAHFYVILLLFEDLWYLRGAFPKEIRNTHMLVVKLGDGALMPLMQWPMAMQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDX3</accession>
    <name>A0A8G1RDX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="13" type="ORF">BO85DRAFT_411427</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDX3"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000079">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH63451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="178" mass="20801" checksum="36EBF400ABC5FC81" modified="2022-01-19" version="1">MKAYWYDNKPGDQREPHDDGRPVDEAYLASLGVLYKYCPKIEDVDALAAERGYKNRDEVTVSPKTMGDVYEEKVKMFFHEHLHEDEEIRYIRDGEGYFDVRGKEDEWVRIKLVKDDLIILPAGIYHRFTTDEKNYVKAMRLFQEEPKWTPLNRSNDLDENPHRVSYLGSLGKAAVAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDY4</accession>
    <name>A0A8G1RDY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Acyl-CoA dehydrogenase NM domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_12388</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520831.1">
        <property type="nucleotide sequence ID" value="XM_025653938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDY4"/>
    <dbReference type="GeneID" id="37157340"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01156">
        <property type="entry name" value="IVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000021">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase IvdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000003">
        <property type="entry name" value="isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000004">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034183">
        <property type="entry name" value="IVD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF18">
        <property type="entry name" value="ISOVALERYL-COENZYME A DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0274">FAD</keyword>
    <keyword evidence="4 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="15">
        <location>
            <begin position="48"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="14">
        <location>
            <begin position="164"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="13">
        <location>
            <begin position="271"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="198"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="220"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="385"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="412"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="414"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH62909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="431" mass="47080" checksum="04FF66560AC23564" modified="2022-01-19" version="1">MATFQKFPFFARQSSRILARCRKPLIQPPALRTLVMKHPKDFVPPTEEDLLELRERVQEFTRREIPEEVAAQTDAQNEFPAEMWKKLGEAGFLGITANEEYGGLGMGYQAHCVVMEEISRASGSIALSYAAHSQLCVNQLSLNGTPEQKERFLPGLLSGEKVGALAMSEHSAGSDVVSMKTTAKAVDGGFLLNGTKMWITNGPDADFIVVYAKTEPEKASKGITAFVVEKTFKGFSCARKLDKLGMRGSNTGELVFEDVFVPKENVLGEVNRGVKVLMEGLDLERLVLSAGPLGIMQAALDLVLPYTHVRKQFGMPIAHNQLIQGKLADMYTKLAASRAYTYATARQIDNSAAEGSGALIRTQDCAGAILYAAERATECALDAIQLMGGNGYINEIPAGRLLRDAKLYEIGAGTSEIRRMVIGRAFNREYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1REG4</accession>
    <name>A0A8G1REG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_410880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521101.1">
        <property type="nucleotide sequence ID" value="XM_025657499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1REG4"/>
    <dbReference type="GeneID" id="37160901"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="9"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH63179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="354" mass="38132" checksum="728BB317947B3D34" modified="2022-01-19" version="1">MKEIINLPGPSTKLIDSPIPSINDDQVLIKVIVSGSNPKDWKVAELANDPNSFLYSRYEHVREGVNQGDDIAGVVEKVGKNVVEFKEGDRVAAFHEMLKPGGSYAEYAVAWAHTTFHLPESVSFEEAATIPLAALTAVISLHHHHGLPTPWSPPSATTTPTPFVIYGGSTAVGSFAIKLLRASNIHPIIAIAGSGSPYVQSLIDPSKGDTVIDYRPGTDSTIASIKSLNLNIKNALDTIVDATSAHVLTQVVTPGGQVDHVLPRDPKDLPGLLSTNTWVNAAHEKANGVDDCRDLCYVFCRWFSRALKDGRFKGHPWQVREGGLEGVKGAMKDLMDGKASAVKYVFRVAETPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VG11</accession>
    <name>A0A8G1VG11_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_385422</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KZ825092">
        <property type="protein sequence ID" value="RAH51829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509751.1">
        <property type="nucleotide sequence ID" value="XM_025656594.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37159996"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="680"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="880"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="256"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="384"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="619"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH51829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1424" mass="161404" checksum="87CD7EB8AC3D8675" modified="2022-01-19" version="1">MPPNNRKKKKPASNPARGFATVSVPSKPKPTESSTPVSTADSKSVSESDRPTPVEGKQQPAVDSKSEAAPSLQNYTPEELEKHLEEAELQLLVEKYASKCRSDAARQVTKLETERRVFRQQAVSINLMEWLPTEVLQNIMHLVETEERELSPLPGRDSGGQKKTVSEEELYMRLWTLKETLLKLGFPEEKVNEALKHMLLYFSGNFATSNREVVCNLDEALDWLALHCTPKELPSYMQTNAQQRNELDRHISWINDREPSQSSTPSLGPNNSKVKKPKSPVKEPSPALQSSPYDSDSSLDPDTLIPKYLDLQTRLYGLRPELFDQPKKGKKGGRKPAEAEQDPQVVRLQRKITSIENDVLFDQHEAEYKWREKLDDLRKEAAFVRRSQPEEKPVQEEAESAEQPEETETKPENGAQPLDNEEATDLLGDMFQDEEPVLELGVITEELKKASVKVRDFGKWTGLSPRRVLEETCKARDTGCKITFKDMSASSHSNRQALEVRWSKPQEVPFPFVWDTTTHNSNAYATFVSMDSVATPNSQQAESFVSTLALFILFPQNSKEGKAYLRLPAVWRELWTEFANAKKLQEDEADKQTVKDLKKLIQDNHGAFEDDVVLSHNFRKRNGTSSKPESPVRGAGVKDSSEPDEELTRIWTEKSSTASFQYMAQGRMNLPIWNFRDDILNTLDTHRALIICSETGSGKSTQIPSFILEHEMKQGRPCKIYVTEPRRISAISLARRVSEELGENKNDVGTARSLIGFAVRLESKVSQATRLVFATTGVVVRMLERPDDFHDITHVVLDEVHERSIDSDFLLIVLRRLMQKRPDLKLILMSATLEAQRFSTYLGGVPVLNIPGRTFPVEMKFLEDAIEMTNYRLLENESNAVEEEMDELALETAQGDTAGSLMTSLDGYSKQTKETVANFDEYRLDYQLIKRLVVQIASSPDMTHYSKAILIFMPDQEKAFVVPPEGMRKIVIATNIAETGITIPDITAVIDAGKEKSMRFDERRQLSRLVETFISRANAKQRRGRAGRVQNGICYHLFTKHRHDKLLAEQQTPEMLRLSLQDLVLRVKICKLGEVEPTLLEALDPPSSKNIRRAIDSLKEVKALTNAENLTPLGLQLAKLPLDVFLGKLIIHGAFFRCLDAAVSIAAILSSKSPFVNTMGSNTQKDIARLSFRKGDSDLLTVYNAYCAWKRARNTPGVSEYAFCRKNFLSSQTLLNIEDIKMQLIVSIADTGLLTLDPSQKALLNRSRSNNRRNFFTIPEEYDFNSVNDTIVNSVIAWSFYPKLLTRDGKGWRNVANNQAVTLHPTSVNKQADASAIKWVSYYHIMQGRNKNYNAFETTAVDDFAIALLCGEAEFKMYSGVISIDSNRIRFSLRDWKSMLALKALSARLREILQNTFREPHRVPSYKQQQWLGLWQMIFAQVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHV9</accession>
    <name>A0A8G1VHV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_200287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510549.1">
        <property type="nucleotide sequence ID" value="XM_025654526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHV9"/>
    <dbReference type="GeneID" id="37157928"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="105" mass="11062" checksum="D63C88A78658C373" modified="2022-01-19" version="1">MRAVEGRRKTSRISQPSRPLIITHTPRPGCIATIGGGLVTAGGDSAGSFHSASRGLPACVAFPERSLGGRLWRGGKERERGGSLLTPSQPLQPDSAIQRAYPCPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIA8</accession>
    <name>A0A8G1VIA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_504172</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511402.1">
        <property type="nucleotide sequence ID" value="XM_025664286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIA8"/>
    <dbReference type="GeneID" id="37167688"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034346623" evidence="4">
        <location>
            <begin position="21"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="50"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="6">
        <location>
            <begin position="477"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="78"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH53480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="637" mass="70341" checksum="63C22271F2033996" modified="2022-01-19" version="1">MRSHLQSAVLFSLCLSPAVATPYIYHRRPVLQEYLGPEADENPPQPTEPYDYVVVGGGVTGLIAAGRLAEHYNVAVVERGGYYEERTGNLSQVPGYTELFDNSNTPPRDDVEHWWEIPGTPETNNRALNFTGGKMIGGSHAFSYFGYLRPTYGAMQKWADEVGDQSWTYPNTEEYFDKSIKFTPPNSTTRLANATPEYDPSLKGTGPLEITYPRWVHPFSTWLAKAFDALGVKHTLSYANGELLGSSWILDTINSTDGTRSTSWTAYVKNAPPPKKKLDIFTYTLAEKIQFDGTKATGVAVTREIPNKSGGPRSIEQFTIETKNELVLAGGGVLSPQLLMVSGVGPEKQLQELNITPVLKNDAVGQNMHDHIVFAVAYRVKTPTSSILLDDEKRWHEEDLFKENVTGMMTNPGPDFGGIVDIPSDLRNFSLSTKADLGSLPKDWPELIVVSFPLGHDYPDDGYNYASLMGVPMTSMSVGNITLNSTKMSDKPVVHPHWLTSTTDLEVSIASLKYMRRIFENPAMEPIIIGDEFAPGPEAATWAEVEHALKNSFRSMHHPAATLRMGREDDPNAVCDSRGSIKGLDNVRVVDPSAFPFLPPGLPLAPAFMFAEKITDNIINDQKSGKKKGHDELRTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIF1</accession>
    <name>A0A8G1VIF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_454664</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DIF1/spd1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825098">
        <property type="protein sequence ID" value="RAH51653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509575.1">
        <property type="nucleotide sequence ID" value="XM_025661338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIF1"/>
    <dbReference type="GeneID" id="37164740"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990846">
        <property type="term" value="F:ribonucleoside-diphosphate reductase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013900">
        <property type="entry name" value="RNR_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28081:SF1">
        <property type="entry name" value="DAMAGE-REGULATED IMPORT FACILITATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28081">
        <property type="entry name" value="DAMAGE-REGULATED IMPORT FACILITATOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08591">
        <property type="entry name" value="RNR_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH51653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="243" mass="26536" checksum="705DF6C42E37D183" modified="2022-01-19" version="1">MSPSLQSPTTTKASDLASKRRRFQPPITSFFSTTSTPPSEDNDNVTTDRTHHLSHNHYSAATCSPTPIVPTKVQASLLSVGMRVRKSVAEGYKTRLAKPDPSFSELAPYSGMRSHSAPMNLITDDEGDAFSLPSSSQESNAGGQKRSHDMDFDLDDSEDDDVAASGLGLSTHNATSMGRTILAPKLNQQRRRFVTLRKHATISEGMGMDIDDFEEASFLRSREEVDMEYGSVSRSSEIEMGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIX8</accession>
    <name>A0A8G1VIX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_491847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511644.1">
        <property type="nucleotide sequence ID" value="XM_025663741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIX8"/>
    <dbReference type="GeneID" id="37167143"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="298" mass="33963" checksum="038DADA39FB39122" modified="2022-01-19" version="1">MDVLDGQKSPLCVAWDNPSSDPDCPTDSPTTPGEDNDDKGHTVAQAALAIPEIVEMILIRLGFADLLRMEQVCRSWQFMMRGSIIIRRALFFEQSSASYNEEPALNPFFKKWFCPACYCKNVGGYFVQRGPSGKFAWFEDAKLREIVLYEKASWRRMWPSTVPVVLEAVSLHTRRQDPGPGISDHVVLKREHSLLRSDTNGMTLSGFLEAMISLMNHSKSPEFTVFWKKTAGNSGRPRWQLIALLNPSQLMSPRTDTKPIYPGISKMDFAELLNDDELSRFLSWTEVVDDYYNTHVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ90</accession>
    <name>A0A8G1VJ90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_377260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513276.1">
        <property type="nucleotide sequence ID" value="XM_025656256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ90"/>
    <dbReference type="SMR" id="A0A8G1VJ90"/>
    <dbReference type="GeneID" id="37159658"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF8">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="260" mass="27694" checksum="30C655D5F37259C9" modified="2022-01-19" version="1">MTIPTDKKKPALVVVPGASQNPAHYAHLLHLLQSAGYGAFTGLLPSIGAQGQVTAADDTDYVRNRLILPLLDVGNQDVILISHSYSGMPASAAARGLGPADRAAQGKSTSVLGQIFIATILPRGGDGLSVIDSFGGNLPPHMYMDKEQNLLKCDEPKPPLFYDVEPTLADAACQTSLSQGLTSFSSPCPEASWGSEAFKDRIAYIHTTEDRAVPYPAQTAMVQATGAKWITRELATGHSAQLSAPEELTKTILELVKQWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ94</accession>
    <name>A0A8G1VJ94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_470664</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513291.1">
        <property type="nucleotide sequence ID" value="XM_025662415.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37165817"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000017">
        <property type="entry name" value="Non-reducing polyketide synthase aptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000011">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.110:FF:000001">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000031">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF24">
        <property type="entry name" value="NON-REDUCING POLYKETIDE SYNTHASE APTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="402"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="1330"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1734"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1330"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1497"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1656"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1656"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1701"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="1362"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH55369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1811" mass="197348" checksum="426A224384853489" modified="2022-01-19" version="1">MKKFTRFGRRFRLILLRRRRLVFFGNEFPNDDLKTLFRGLHRHGKDRRFRQLATFLEESTRVLQNEVAQLPEPLKKLVPHFENLMPLTEVDFRQGPLGAAMESALLTILELGMFIGHYEAEERVWDLSADRTTLAGLSIGLLAAAGVALSTHLAEVVQNGAECVRVSFRLGVYVHDISRKLEAPQADGSLLSWAHVVTGETASDLQEELSRYNTETGTPELLKVFISAADKTSVSVSGPPSRIRAAFRASQRLRYSKSLALPVYDGLCHAAHLYDEETIHRVLHPSGSVIPTSRPVQLALLSSRSGQPFEATTAAELFRAISTELLTGTIFLDNITAGILDRTERCAETAQCQIETYRTSLVFKGLLKALEACFPDRTISTTDLIPWVFQDYGARQPKSCADSKLAIVGMACRMPGGANDLDLFWELLAQGRDTHTTVPADRFDLETHYDPTGETENATRTPFGNFIDQPGLFDAGFFNMSPREAEQTDPMHRLALVTAYEALEMAGVVSGRTPSSNPKRIATFYGQASDDWRELNASQNIGTYAVPGGERAFANGRINYFFKFGGPSFNLDTACSSGLAAVQAACSALWAGEADTVLAGGLNIITDPDNYAGLGNGHFLSRTGQCKVWDQSADGYCRADGVGSVVIKRLEDAEADNDNILAVVLSAATNHSAEAISITHPHAGAQKENYTQVLHQAAVNPLDVSYVELHGTGTQAGDAQEAESVLDVFAPRNHRRRADQPLYLGAVKSNIGHGEAAAGIASLLKVLLMYQKNEIPAHIGIPTVINPAIPTDLEQRQVHLPRSKTAWPRAAGQIRRAIVNSFGAHGGNTTLVLEDAPEKQVTVAREERSTHPVVISAKSKKSLAANLETLLAYLDEKPGTDLGDLSYTTCARRMHHSWRVATAVSDIPALQKFLRNAVNNDAVSQIRPIPTEAPPVVFTFTGQGAYYAGLAQGLFQALPSFRAEVRQLDHLSQRLGFPSIVPVILGEVEEGTATALVTQLSIVIVEIALARLWLLLLGIPAPHAVIGHSLGEYAALAVAGVLSTADALYLVGHRAQLIEEHCTPGSHAMLSVRATITDIERLVGTGPDAPTYELSCQNTHQDTVIGGSIPDLNAIREKLEPEGIKCVNVEVPFAFHTAQMDAVRERLAKAVAAVPFKTPSVPVLSPLLGSVVFDGKSINPEYIVRATREPVQFATAIDAAQELGIVNNQTLWVDIGPHPICASFVRSLVPGARIVSSCRRNEDNFATMAKSLCTLHLAGRTPSWAEYFRPDEQAYSLLRLPKYRWNEVNYWIQYLGTWTLDKAHIKNGSSQKRAITDVPSVSSLRTSLIHQVTEESVDKTTATFKAISDIQHPDFLEAVHGHTMNNCGVATSSIWTDMAMTVGEHLYRRLVPGTDNVLMDLCDFEVQHAQVANTNSNTPQPLALEAHLDLPTRHMSLAWYDVDATTNQRAAAPFATGSIKYPADPTGAVWSTEWSRITHLIQGRIDALQHMAAENKASTLSKPLAYALFKNVVDYAPRYRGMDRVVIHDHEAFSDITLTTDRHGTWHTPPHWIDSVSHLAGLVMNGSDASNTRDFFYVTPGCGSCRMTEPLIPGGKYRNYVRMFPMPDEAHMYAGDLYILREDKIIGVVEQLKFRRVPRLLMDRFFSPNKNAAAHAAPAPAPAAAPVVKKQPPTPTPTETVTSQPAKTEQKQVQHHLPNLTSAAPSTASSSSSPSSSGVATPTTEQEAPVADASAVTGVAGKCLELIANETGLGVAELTADAAFVQLGVDSLMSLVLSEKLRSEMGLEIKSSLFLECPTVGDLTGWLEQYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJY4</accession>
    <name>A0A8G1VJY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">U3 small nucleolar ribonucleo protein LCP5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_451168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513863.1">
        <property type="nucleotide sequence ID" value="XM_025660527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJY4"/>
    <dbReference type="GeneID" id="37163929"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="388" mass="43272" checksum="DEC5209918FC9223" modified="2022-01-19" version="1">MAAAVSQSEPSGSQNISALLETLTTCLNSTGSSLPKTKRDAPSDVSIEPPQDGISLLDTKSDLLLSYMQNLVFLVIFQLRGLKSSADKDAEKNDSLPDDIVKKLVELRVYLDRGVRPLEGRLKYQVDKVIKAAEDAERAERGATAPKKGKKAKKSARDEESGSDEGSSDSEGDSEEDEEDEEEEEDIDEMAFRPNVSAFSKKVEPEAKQDKAAARATSDGIYRPPRIMPTALPTTETRERRERPQRRSNVIDEFVSAEMSSAPMAEPSIGSTIVRGGRQTKSKKDREREAERTRYEETNFVRLAKESKKDRAKRLRAEGPRGTFGGEEWRGLTEGADRITKLTRRSQGSGSALDRSRKRKNEDGQRDDGMGVGQIFEKRRKKVDSWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJZ3</accession>
    <name>A0A8G1VJZ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alb1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_489575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514101.1">
        <property type="nucleotide sequence ID" value="XM_025663610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJZ3"/>
    <dbReference type="GeneID" id="37167012"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053278">
        <property type="entry name" value="Pre-60S_factor_ECM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022784">
        <property type="entry name" value="Ribosome_bgen_Alb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28280">
        <property type="entry name" value="SHUTTLING PRE-60S FACTOR ECM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28280:SF1">
        <property type="entry name" value="SHUTTLING PRE-60S FACTOR ECM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09135">
        <property type="entry name" value="Alb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="130"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18512" checksum="610E891717E8C893" modified="2022-01-19" version="1">MAKSRPQSKHSRAARRAASPSLDVDKSITSLPRAEETTVQRDSILSERANAGVSKKASKGKAKTRAQRLRQQKGVERAEAVMDQLEKKVVKSEGRAKSVKARRAEWEDLNRKTKSMFEALNEADDNMDDAMMDDAAASKPAKRSKPAPVTQAPVVEEHEGIDVDDDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK15</accession>
    <name>A0A8G1VK15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dual-specificity kinase</fullName>
            <ecNumber evidence="1">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_101914</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512754.1">
        <property type="nucleotide sequence ID" value="XM_025653779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK15"/>
    <dbReference type="GeneID" id="37157181"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:regulation of RNA splicing"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase AFC2"/>
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    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="311"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="60"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="128"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="183"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RAH54832.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="675" mass="75739" checksum="35D540D8E9D3E55F" modified="2022-01-19" version="1">MSTPSTATATHPHQQHYGYPHHQPYQPNASYPTTSAAATSRLVPSSYPYPVSAPTPTTLPFVQSPKLMPTAPTPTTTTTTNTTTATTTMPPAHNAVSAGTTAQGTRRRKPNWGEFYKNGIPKEVIVIDDTPPPEQSKASSRSLATASTVTAANGNAPQPAGKKRRTGIESAYDVTYYDRPSYSINPQHYGEESSAASLSTDRTTSLHTTAPTSLSQGSSGASNGIIYEDANVGQKRKRVTTRKSARDEQKRRELENAGDAFLSYVPPPKPPIKAKDVPVPVVRDYANRGEKYDDDDGHYIVNPNTPLTERYSIIKLLGQGTFGKVVEAFDKQRKTRCAVKIIRSIQKYRDASRIELRVLSTLASNDKQNRNKCIHLRDCFDYRNHICIVTDLLGQSVFDFLKGNGFVPFPSSQIQNFARQLFTSVAFLHDLNLIHTDLKPENILLVSNAYQTFTYNRTIPSSSHAISRSARQRRVLLDSEIRLIDFGSATFDDEYHSSVVSTRHYRAPEIILNLGWSFPCDIWSIGCILVEFFTGDALFQTHDNLEHLAMMEAVIGDRIDTRLVRQVMQGGRSAGQNQAAKYFNRNKLEYPNDQTTRASRKYVRAMKQLPDFIPTNTKFHKLFLDLLQRIFVYDPKNRITAKEALKHQWFKESLVDDGTEALRIGEQLQRTTQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK54</accession>
    <name>A0A8G1VK54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_60849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025665522.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH56181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="190" mass="20678" checksum="2542C3AFE8E888FA" modified="2022-01-19" version="1">MPPKKRSAPSSGPAPKRARQSKLAKENDISASEENEIKEVFHLFSETVEEFADQKEGVIPRGDVRKALVALGLDPTDSEELHSIISAVDPTDTGYVLYEPFLAVAAAKLRSRSDDAMAAEVDAAYRLFTRGSGGLITFNHLKRIARELKEDDLGDELLKDMILEANGGAGVHAGVTLEQFHDVMTRAGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK78</accession>
    <name>A0A8G1VK78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_452992</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511375.1">
        <property type="nucleotide sequence ID" value="XM_025660964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK78"/>
    <dbReference type="GeneID" id="37164366"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH53453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="413" mass="46106" checksum="DB41B16E4E1E8518" modified="2022-01-19" version="1">MAIPSSITATLITLLLLPILLALKRLYFHPLSRYNGPLLWALTRVPYMLAFRNGKLAHKIKSFHDVYGETVRVAPNEVSFINPDTVKDIYQRRPSGGGFKSLPKDPIRQAPPRPGQPISILDAGDSDHTRLRKAYAAAFSSQALSAQEPLVASYVDKMITQMQSQSELATKKVDLQEWISFCTFDIVCKLSFGEDFACLDNQRYHEWVGQLVYSLKAKVQLASCRFYPWLFNYLVKRLPKSAGVLMAQHQATTKEKVKRRLQQLDSDASAEGNDAAGVTRPDFLAHLVQQQSRREISEGEMVVNAATLIVAGSHTLQTAITGILFHLLRNPTIMDRVTSEVRSAFLSADQINVSTLLRLPILEAAIKEGIRLTSPVPLGLTRLVPIGGHTINGEYFPEGVSHFCLHFSHYLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKB0</accession>
    <name>A0A8G1VKB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_450394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514283.1">
        <property type="nucleotide sequence ID" value="XM_025660366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKB0"/>
    <dbReference type="GeneID" id="37163768"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="253" mass="28780" checksum="1451637FAB0334AA" modified="2022-01-19" version="1">MASQIPLNTETRTTFYTERRGPIQTDVPLRPGTPPPPPPPPPDSPTTHPKPRAPYPSWKISHVWFHLPPGAEDFHDNSWPPYRHGLWIEHGPAGRGHPHHVVGNSFDREGLIYAVKHFKHPITNEPTYAGETVIGYLSPERYPDLKQAFLTCQPPLQQKKYNRRTDVTEPFGVNEDGQTVFYTQYRLENFMFPPLKLDRYFVKLQLLEKVREMTLSRCQAGEFVVLSGFFPAEEWDEPEELGLGLGSAGEGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKD8</accession>
    <name>A0A8G1VKD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_450069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514581.1">
        <property type="nucleotide sequence ID" value="XM_025660296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKD8"/>
    <dbReference type="GeneID" id="37163698"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH56659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="54" mass="6050" checksum="DCD4B8A64DA5E350" modified="2022-01-19" version="1">MMAEVAKYLSSLVAFSPRFPAELQPDRNEGSIIRIALGVIVHPQLHRESNCKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKS0</accession>
    <name>A0A8G1VKS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase acuF-like C2H2 type zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_451204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513907.1">
        <property type="nucleotide sequence ID" value="XM_025660536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKS0"/>
    <dbReference type="GeneID" id="37163938"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053268">
        <property type="entry name" value="Woronin_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40641:SF2">
        <property type="entry name" value="INVOLUCRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40641">
        <property type="entry name" value="INVOLUCRIN REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_2G08060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase acuF-like C2H2 type zinc-finger" evidence="2">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="937" mass="104253" checksum="4D2877393C4AB803" modified="2022-01-19" version="1">MTSIRKAGINARIQKADASYDPGHPQVEALKSHLQLLLLSRPRYYGTLQAETSSHGVLLVSSIDGTIVSEPRSLTVIQRRLIEANLKRRNRFLYAQRHAIKLSDREPPPAKSIPTSRKTPQPLILNPNARSTDEPKLPTVYSTTTATEVQDPIPFPTRDSAQPATTIISAISSRVTYPKPPQLRPDQNVFQCPCCCQTLPAFMSKGSQWKKHLSRDILPYTCILEECPRPERNYHTKDLWLSHMSTDHGGFPHWVCLACNESSERPTFYEESAFTKHLDETHSTGIKPHQIQMLVSAWRRKTPVTVGSCPLCGLTDLDVEAVLNHVAEHLHSFSLKSLPWAPGDSESNWDSYGGYYEDHPYFDTARSEDTRRSEDTGSVGSGSIDPFDPLDYLPIKEYDEEPTENNQLTEERIHCLSEDPGTNQDMMGVFLASIENEDPVTAPFQTPPSPASPDSDLSVDVEEVGRVSESHHLPSLSLTVPTDSDDDDSPAVRPPLPAPSDSEPSTDGEDEHQDSASHNPPSSSPAESGSYSNNESAPPGFQSSSVAEEWHLSHDLSRFIDFDATPPHRAQKAEAAINAGAVATGFFSFSEMVLSQPSLPQDISSAGELPSTSIVLYDRHHFHDSLDTLYLLCSNWVSDFSEPFSNVLCRSLDNLHPANNRDRFRDAILNGSDVDALLADPIHRRHIFMSVTTTMIWEFIFTRYLFGLEWSIRSGIKRLEKELGQTLPQEVVHRWRATTLNSLSQDTELKQQQERDIQAVSLTIIDTLMSILSERSPYKPRLREELDDVLRLAVKLSVEMRTQLAEYIMLPPLQPEYDSQGNLTSQIFFNASLMHEESGVYASNEQAQSEQAVVHLVLFPLVVRKGDDDGKGDEEVVVYPAQVVVSDILDRGRPHPSPSHDTGDVSAANDEADYDSDRTSAGSAPSQVSVDVRGVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKU2</accession>
    <name>A0A8G1VKU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_451480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513609.1">
        <property type="nucleotide sequence ID" value="XM_025660600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKU2"/>
    <dbReference type="GeneID" id="37164002"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="343" mass="37165" checksum="C375D37B7B7687C9" modified="2022-01-19" version="1">MSDSTTINNTLASPIGSLASSPGSTLASQSDSPRPRLSASSGFGFASASAWSEIYQNEPEKAPATQLLNISDNPDHLEIDPSSLKEHSHFSDDSTDSMEDYDIVSGASSPSSLSFQIVEPEREKLYPIAITVFVGSPRAQKDRPVHLSCIVLTSDWRQDFFPNSCKNKADKAVKCKDIIKYNEQCLPQIAKFACAICSEPTPARKFVHQPIMFTRTSKSGLEDGPRRRLIMRLGQLVHSRWKFPDMNATLGGSAEAQVFEVAIPVCKRSGCGIAGRTSAHQLIRAIVSSNADLDPSALDLDIVIPLADLGTGIGDWTPDRAEILVTKLGPDCVPLEVRSHVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKZ1</accession>
    <name>A0A8G1VKZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_449784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514973.1">
        <property type="nucleotide sequence ID" value="XM_025660232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKZ1"/>
    <dbReference type="GeneID" id="37163634"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140849">
        <property type="term" value="F:ATP-dependent H2AZ histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037651">
        <property type="entry name" value="Swc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057558">
        <property type="entry name" value="Swc3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108:SF1">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24707">
        <property type="entry name" value="Swc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWR1-complex protein 3" evidence="2">
        <location>
            <begin position="64"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="871" mass="95508" checksum="7D4C17102ED5E953" modified="2022-01-19" version="1">MAEKRKLPARERREPAAKRRASEAPSRPSPQPQQSKKKGSTPVVAPSPPPPPPPEPAEPPLPTKIKDGEPLPTTAAPQPTTLTDKEYQSYAESAILLASLERSKKKWLSDGILERYWTKPKKTKREQIEGKNPPKETMSKVGACNIVVGPHLFDAMLYTVKDPNAPPPIQYTTPQRPMVHYGHPNNFQQYHPYPHSPAPPQHARQHPPQGSPATPGTPQPGYTPGNHPPPSHPARTPSQPPHRPPGPQSAQRPSPSQHPQTAQPPKPSPDPVIQMLATRAASDPELKALMRVVASSKASQEQLRAFQAHIDELNAIIRAREQQQQRLQQQQRQVQPSTPSQPPPRPSQTPIQHPQPQQTPQSSQPPQQPPSAQKPPPQPVQQTPQQPPQQKPQQTPQQTPQGQSQPQPTPRVEVQVPKPSPSVAPAHPPPNPNVPQPPQTPTPQAPKPASQVVIKQEPGVAAPGQPPSQPVSSPSVAPAPTPTPDPQKQASPAVRPMPPPQQQPTPRPGPPHPPYQQPPYQSHPPAIQSRPPQYGSPAPYYRPAPPPPPPRQNYKSVVFEFTSPLTPYGSSTSGHAGSGDRYLFPEYTILEWLPGGNTVLASFLLVRKVDPNATFPLESATETANPRAKGKASKSKSKKADKNKEKAGEADKDKGKAEDKEKDKPQEKYNDKPESSGTEPKPDGDKAPASSTQADQKAEASETPNKPSTDKDDSKDKKVDSKDKDKEKENKEKEKDKNSNLKEYYQPVTFRIFTNNPKVLEPLGRVVKPPDEVRKYMNEIMDRAERAPEGFLAYRLPREEPEDNKPAPETEDSGKKTGTPVPAARGRLQSRSKTVDEESDVENIEGAVEEEEEEELKDFYGPPTGLPPMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL54</accession>
    <name>A0A8G1VL54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mannose-1-phosphate guanyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_459966</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="4"/>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515168.1">
        <property type="nucleotide sequence ID" value="XM_025661687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL54"/>
    <dbReference type="GeneID" id="37165089"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071554">
        <property type="term" value="P:cell wall organization or biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05824">
        <property type="entry name" value="LbH_M1P_guanylylT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000017">
        <property type="entry name" value="Mannose-1-phosphate guanyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="16">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="17">
        <location>
            <begin position="256"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH57246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="364" mass="40182" checksum="46DFDC7C56D0E18F" modified="2022-01-19" version="1">MKALILVGGFGTRLRPLTLTLPKPLVEFANRPMILHQVESLAAAGVTDIVLAVNYRPDVMVSTLKKYEEIYNVRIEFSVESEPLGTAGPLKLAEKILGKDDSPFFVLNSDIICDYPFKELAEFHKNHGNEGTIVVTKVDEPSKYGVVVHKPNHPSRIDRFVEKPVEFVGNRINAGIYILNPSVLNRIELRPTSIEQETFPAIVKDGQLHSFDLEGFWMDVGQPKDFLSGTCLYLTSLAKRNSKLLAPNSEPYVYGGNVMVDPSAKIGKNCRIGPNVVIGPNVVVGDGVRLQRCVLMENSKVKDHAWVKSTIVGWNSSVGRWARLENVTVLGDDVTIADEVYVNGGSILPHKSIKQNVDVPAIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL96</accession>
    <name>A0A8G1VL96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bromodomain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_372697</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515303.1">
        <property type="nucleotide sequence ID" value="XM_025656050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL96"/>
    <dbReference type="GeneID" id="37159452"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="6"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH57381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="121" mass="14445" checksum="B35872FFDEB3435D" modified="2022-01-19" version="1">MDKLAREPRHGPHFNELRRFLSQIQAHKQAWPFLSPVNKDEVPDYYKVIESPMDLPTMEERLENDSYSTPKALVDDLKLIFRNCRQYNEATTVYSKCASKLEKYMYSLIKEIPEWFDLLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLQ6</accession>
    <name>A0A8G1VLQ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_449703</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH56975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514897.1">
        <property type="nucleotide sequence ID" value="XM_025660211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLQ6"/>
    <dbReference type="GeneID" id="37163613"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071265">
        <property type="term" value="P:L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000002">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000003">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="18">
        <location>
            <begin position="4"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="17">
        <location>
            <begin position="443"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="395"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="712"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="448"/>
            <end position="450"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="448"/>
            <end position="450"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="532"/>
            <end position="533"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="578"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="616"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="616"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="659"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="661"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="670"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="683"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="744"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH56975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="774" mass="87157" checksum="D3DA538CE9AF41C2" modified="2022-01-19" version="1">MVQSSVLGFPRMGKLRDLKKATEAYWGDKISRDELLAEGKRLRLEHWKLQKDAGVDVIPSNDFAFYDQVLDHIQLFGVIPERYSKYNLHPLDEYFAMGRGLQKPAKDGQAAIDVPSLEMVKWFDSNYHYVKPTLQDNQTFKLAEQPKPVVQFLEAKEAGVVTRPVILGPVSFLTLAKADRGQSVDPITKIEELLPVYVELLQKLKEAGAEEVQIDEPVLVFDLPAKSKAAFKPAYEKLGALGAQAPRLVLATYFGDIVHNLDVFPALQNLHGIHIDLVRNPEQLDAVVAALGPKQILSAGVVDGRNIWKTNFKAAIEKVELAIQKLGKERVVVATSSSLLHVPHTLESEKTLDPEVRDWFSFAVQKLDEVVVIAKAVTEGPAAVREQLEVNAKSVQARASSKRTNDPKVKERQAAVTEEQHNRQSPFSTRIAEQSKSINLPLFPTTTIGSFPQTKEIRIQRNKFAKGEITAQEYEKFIEKEIEEVVKIQEELDLDVLVHGEPERNDMVQYFGERLTGYVFTTHAWVQSYGSRCVRPPIIVGDISRPAPMTVKESKYAVSISKKPMKGMLTGPITCLRWSFPRDDVHQSVQAQQLALALRDEVVDLETAGVKVIQVDEPALREGLPLRAGKEREEYLKWAVRAFRLATSGVTDGTQIHSHFCYSEFQDFFHAIAALDADVLSIENSKSDAKLLKVFIDEAYPRHIGPGVYDIHSPRVPSEQEIKDRVEEMLQYLRPEQLWINPDCGLKTRQWPETKAALTNMVNAAKFFRQKHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLX3</accession>
    <name>A0A8G1VLX3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_449935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515122.1">
        <property type="nucleotide sequence ID" value="XM_025660269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLX3"/>
    <dbReference type="GeneID" id="37163671"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF6">
        <property type="entry name" value="ISOCHORISMATASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH57200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="191" mass="21059" checksum="98E688664CACE8D7" modified="2022-01-19" version="1">MPRTAIFVIDIQNHIAVDPTSRVPQADRVIKASEEILQTARSIKDSNEKSNSPLIVFIQHEESANDGALVKGTEPWGLVFHPRADVEGEILVAKRTGDTFKSNRDLAQRLRDANVTEIVAFGLQSDKCVEATCTGALAAGFHVTVLAGAHSTYDADGKTAQEIEREVELRLSTRGARVVRWEKWVEKQQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM07</accession>
    <name>A0A8G1VM07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="11">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lipoate synthase</fullName>
            <shortName evidence="11">LS</shortName>
            <shortName evidence="11">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_449236</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="11"/>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516053.1">
        <property type="nucleotide sequence ID" value="XM_025660118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VM07"/>
    <dbReference type="GeneID" id="37163520"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="8 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Elp3/MiaA/NifB-like radical SAM core" evidence="13">
        <location>
            <begin position="154"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH58131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="416" mass="45573" checksum="BBC774BBEB26D656" modified="2022-01-19" version="1">MAAASTNRLRLLYTSTRASLPQSTPSILTTRTYATTDSSTSATSTPKPRRRTAFTDKLNAGPSFGDFVSGNNDNAPLLEPSEAYALETALVGPAGRKKQMTRLPPWLKTPIPDSKNYQRLKKDLRGLNLHTVCEEARCPNISDCWGGGDKAAATATIMLMGDTCTRGCSFCSVKTSRRPAALDPHEPENTAEAISRWGLGYVVLTSVDRDDLADGGARHFAETVRKIKSKAPSTLVECLTGDYRGDLDMVALVANSGLDVYAHNIETVEALTPRVRDRRATFKQSIAVLEAAKKANPEVITKSSLMLGLGETEEQLEHALAQLRAVDVDVVTFGQYMRPTKRHMAVHEYVHPKWFEHWQRRAEELGFLYCASGPLVRSSYKAGEAFIENVLKKRRAGVSDAVTEKKVAAAVDDATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM87</accession>
    <name>A0A8G1VM87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_449525</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515452.1">
        <property type="nucleotide sequence ID" value="XM_025660179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VM87"/>
    <dbReference type="GeneID" id="37163581"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000001">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000020">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="VOC" evidence="14">
        <location>
            <begin position="27"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="14">
        <location>
            <begin position="203"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH57530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="405" mass="45802" checksum="64EDE6B0B9596839" modified="2022-01-19" version="1">MAPSAISSPPSPQPATATTSDISSYKGYDHVHWYVGNAKITASYYVTRMGFKRVAYRGLETGSRAICSHVVRNGDITFVLTSPLRSLDQMEHLTPEEQKQLREIHEHLEQHGDGVKDVSFEVDSVDAVYQAAVANGAKIVSAPRSLEDKDGYVRVATIQTYGETTHTLLERKSYSGAFLPGYRPEDGPEDPITKYLPGVYLNRVDHCVGNQDWDEMDRVCQYYEKALGFHRFWSVDDKDICTEYSALKSIVMASPNEVVKMPINEPAVGKKKSQIEEYVDYYNGAGVQHIALLTDDIIRDITNLKARGVEFIKVPDTYYEDIKIRLKKTGLVLHEDFETIRNLDILIDFDEGGYLLQLFTKHLMDRPTVFIEIIQRHNFSGFGAGNFKSLFEALEREQALRGNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMD3</accession>
    <name>A0A8G1VMD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_376736</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513505.1">
        <property type="nucleotide sequence ID" value="XM_025656235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMD3"/>
    <dbReference type="GeneID" id="37159637"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000035">
        <property type="entry name" value="dCMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002333">
        <property type="entry name" value="Deoxycytidylate deaminase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="192"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH55583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="350" mass="39634" checksum="14359C48E39F36DE" modified="2022-01-19" version="1">MLILCGKAICSGKHAVADYLIQKEGFRLLKLKDVSSLRVTDEADGDRQLQAVEFAEDESSPPPHLIFEDSKALLDFVTKRWQEHWVTTDIWDVTILDRFFQRPFFLLVSVDAPVSLRWKRFVDRCRDRLVEPPPLEKFVLWNDRHLYDKNVGRAYLTDRAQVRLFNSSSSFDELHAALKALNLADEERLRPNWDQYFMELASLAAQRSNCMKRRVGCVLVRDRRVISTGYNGTPRHIRNCNEGGCPRCNRGEGGGVGLSTCLCLHAEENALLEAGRERIREGAILYCDTCPCLTCTVKITQVGITEVVYSQGYNMDNDSAAILKAAGVKLRQFSPPRKGLIYLESSGGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNN7</accession>
    <name>A0A8G1VNN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_513091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516714.1">
        <property type="nucleotide sequence ID" value="XM_025664684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNN7"/>
    <dbReference type="GeneID" id="37168086"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF1">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="227"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="453" mass="51725" checksum="A63E25BEDACD85C6" modified="2022-01-19" version="1">MTTPSTMYTPDPMDIDESEDSASSTTSSDPMDMAPPTNTTQSLAASEIGLQPSLRPSGPETDLHPHLRAQRYKERYPEGTPRWTKEAIQEAQARVERCKPGDIVYISALDGADVGFEVMTERIERNKQGVAMVGVKHFLELFPAPTDYITPSPETRHPSHLYSNLALGHKFRRLDGEDEDDEEDDYDDEDPTKKEIASAHESFNTIFHTWTDSALYKNMLATLRKLPTIKRPVSKIIAFGCNSITNLRLDKFTRERSAYQHAFLLMLQRILQEMAWTPTEIEIVLQDSAYTKLDKEILSDCGMTMLESPQAFLLVDDESFIFSYAPDVPVRQVVMDLAMPVGMVWDAVVAEGMSLDTRDPWDTTIHRKINKNYNTFHLPKDKHFDMLRVYLRCADGELSDTECERREEKMLDTMDFVQRNKLLVSWGKDNVQDVYSVYHRMRGSQGSDASSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPM8</accession>
    <name>A0A8G1VPM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase 14 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_446317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519066.1">
        <property type="nucleotide sequence ID" value="XM_025659473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPM8"/>
    <dbReference type="GeneID" id="37162875"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="96" mass="10907" checksum="719D4491CF173D28" modified="2022-01-19" version="1">MVHKVLFWGGFGIAVRLWQLGIEMRPILAKESLWVYPLFAGVGGSFGYWLQGVENRQLRILAQRREAILEKRRRRDERESVGLSKPEEAGVLAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPV2</accession>
    <name>A0A8G1VPV2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_390917</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519113.1">
        <property type="nucleotide sequence ID" value="XM_025656792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPV2"/>
    <dbReference type="GeneID" id="37160194"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.490:FF:000005">
        <property type="entry name" value="Nucleoporin complex subunit 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.3600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18570">
        <property type="entry name" value="Nup54_57_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="434"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="158"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH61191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="475" mass="51431" checksum="2ADA179E63DAE470" modified="2022-01-19" version="1">MSLFGQAAAPSTGGGLFGQANNTANKPSPFGGGGGLFGNTSTTNTTQQNTTGGLFGGATQTQQPSGGGLFGGATNTQTQQPSGGLFGQTATQQKPAGGGLFGGLGQTQQPQQQQQQTTGGSLFGQKPLGGGGGGLFGQQQQSQASQQQGGGLFGGLGQTQQPQQQQQQPSLFGGSLLGGQQQQQQPAQQQQQPQLGQTQMGQSTAQLGSSLWEPGRAVTGVHRTVPMQIQIVKDKWDASSRSSPFRAYLYNNVGEEMAPFYQPGPEDDDTKWEDALRKRPDSGYVPVLVKGFFELGKRAQRQKDFLTMMQTRLHEINNCLSDLLSRHDLKISVKIADCRRKHLVLSKRCLALAAKTQVLRNRGYAMDDAEEELKKKLSQLERSVFDPSLNGRAEEIWARMLAIREHSRRLQQEMERAGPSAAAQADDELDEQTMKTAKKILDDYHTQIQHLQKELEAVRKDFEEAQKLPGGAVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ69</accession>
    <name>A0A8G1VQ69_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_448502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516370.1">
        <property type="nucleotide sequence ID" value="XM_025659947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ69"/>
    <dbReference type="GeneID" id="37163349"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="159"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="402" mass="45973" checksum="3541B481F588BA21" modified="2022-01-19" version="1">MWGCDVEDCNRPAVRLDGDCVICDRHFCDEHIEHGCPKWQVTRRNISCSQVLTYLTIHIKDGELYDLAAQEAERGEITRLLDSLNLSALLKRATYLRNGIACCSPQPLVYDRSKRSSVMGGMNYHIEILFADGVQWLARIRRSNATSPPPELRDYIICSEVATLRFLDNMKVRVPRVFDYALKGQTPVGVGYILMEKLPGKSLRWSLASQEQRKKVMTQLADVYIELERFAFNSMGSMNEPGSDHIAPFARESLTEYVNSQMVSLGPYKDPREYLQSSIELIMRLILRGECYAGREIDAFLVHRFLLDCIPRIIEHHTYDDGRFYLRHADDKGDHILVDGDYNITGIVDWEWAHTDSKTEAFKLPVMLLPVSDFYEGVNTVSEDESTFADILEAKGNKDLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQA4</accession>
    <name>A0A8G1VQA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_447229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518587.1">
        <property type="nucleotide sequence ID" value="XM_025659677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQA4"/>
    <dbReference type="GeneID" id="37163079"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="52"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH60665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="207" mass="23710" checksum="A37A88233D26E165" modified="2022-01-19" version="1">MANNTQYGGDPLPDVGATYPSQNNQSKSSEDDWTKRPPYSIRSPEEFGPVKWRGKCQCGQVTYQSSRDRPLKSKFCHCRGCQVTHGAPFQWAAIFHKSDLAFTKGAEGLSFYSSTNDTQEYKLPTKVYCSYCRSPIMDEGRNVCLMFPQAIESADHDEHRQHWREAFEPECHIFYGKRVLDIPDGKPKWSGIDEQSDLLDEQGRKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQD9</accession>
    <name>A0A8G1VQD9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_366561</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518692.1">
        <property type="nucleotide sequence ID" value="XM_025655786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQD9"/>
    <dbReference type="GeneID" id="37159188"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH60770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="585" mass="67366" checksum="7B4B21F5263EBFB5" modified="2022-01-19" version="1">MSGRNAPRSKNGCSTCRRRKVKCGEERPVCKRCFNLRLNCEWGIPVKRGKANAPVRHLQPAQPRWPTSDGITTCSSPSATTPSPVRAAVTNSILHPHYANTLAALWHRQSPGPAPDLTPVSPDVSFPTGWPFPPYAQPSPLYRPLPGTGALPCTNSLVLSEHDQKYFQYFPSSSVVFYYMKNWQWSSFRYLYEGPAATSKVIMRMILALSASDMHRNGLVVRSPGRPTAEDHGRYHYGMAVKEFRQLLETPKPQVSFAELEMIFATMFLMVAYEWQFGHCVRHLHLHLQGVRSLLETHPELFHVRDVNEVLLAMEADQPSDTVSRASFISDQFLLWILYIDVNRRSIGTTESLYDYVLNSGNESLHPDHLYRCARLWSRCFWGKQYPDQEVSDDMENYRGLEFVHVGYTLWHKLWKCLDEKHTESGDALFAEMMTVRDKYSDLLLTAKLASPGSTRRTLNTIYMAVNNFYALILFHRRLFDTARPPAALHRQALNNIIDNAHKQYAADPRLLRRLHWPLLMAIVETDDPAQREWLRERLYELRSFHSEHLWAFQLAEEVLARQDASAGEYANLAELLRNHQIRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQQ0</accession>
    <name>A0A8G1VQQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_516810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520206.1">
        <property type="nucleotide sequence ID" value="XM_025664868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQQ0"/>
    <dbReference type="GeneID" id="37168270"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="254" mass="27584" checksum="83E74613FF9AAE39" modified="2022-01-19" version="1">MATLVFIPGAWITRELYQPFLNACSDAGYPVHYADYPSIDPADPTVADCKTDTDVIRNTLHKLVEEEGKDIFLMMHSYAGMPGAAAARGLAKSQRVQQGKRGGVIGMVFIAAFLVPEGVSCAGLQGGNLPPWILLDKPTANLNVPADAVANFAGDVDPALLKDLNEKVKPHATLAFTSPQPAPAWAEQAFQRRLAFIVTTGDPAVPKEAQYGMMAATQQQWIVKEIDSSHCAPFIDRIGETVRLMDECVKEFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQS7</accession>
    <name>A0A8G1VQS7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3237 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_446235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518994.1">
        <property type="nucleotide sequence ID" value="XM_025659460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQS7"/>
    <dbReference type="GeneID" id="37162862"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH61072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18134" checksum="626400C13F4F706E" modified="2022-01-19" version="1">MSEFPTLQPAFTFKVTIDAPLGVGSASRQNSLQVVPMTGGTVQSAPGFSPALDAEFVGVGNDYIHADADGKHLRLDAHGVIKPKDGDDLIYLNYTGVCTLLPEVQAVFAGAAPDGSTPFNSAFTHITFETGSERYKELENRVFIAQGRFNIEKGKPTVVEYRVSQVVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQV2</accession>
    <name>A0A8G1VQV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_466532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519172.1">
        <property type="nucleotide sequence ID" value="XM_025662133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQV2"/>
    <dbReference type="GeneID" id="37165535"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="446" mass="48671" checksum="9508E41BDC6EB3B3" modified="2022-01-19" version="1">MENSGAATAPSCGAAEAGARLESSEFPTLDCFGFSAATVHYQDEVDDPHRPALPAASPLSAALTATVPFPNLDDLTPTAHHTSYSKSEPSSPGIISASTPSPDSKAPFVRGHRRRSTHVTRRDLEKFRKEVLGLESSGFGFDDDHNLPKPNPAVDPEFNALNNAFDSANMSMNSSGGMTGSSPGSAMFASYGDNSGGASGMSNVPRPSMSPAMPHPPAQVNGGGMPGMNGGVPMNAGHQMDLHHLYDMVLELSDVLKNNREMTKSIVTSAEEIMKRSGSEGANPTLQQVNGEITGARITELERALAKERRLVEVLRTEQAENAKLIGEYEATLGTMVEQIRNYCQNNNMHYLSQKRHYNNLLQAERDSHLESRLDRDYWHAQTMKCAEMIRTAYRLRSEEEELPIRIVAGLQNEVRAYRNALGMEPERPEDEFGWEILKDVPGSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRB5</accession>
    <name>A0A8G1VRB5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_516316</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519652.1">
        <property type="nucleotide sequence ID" value="XM_025664839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRB5"/>
    <dbReference type="GeneID" id="37168241"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46496">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46496:SF1">
        <property type="entry name" value="ZEAXANTHIN EPOXIDASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="10"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH61730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="407" mass="46134" checksum="826FE4041F2B6EA5" modified="2022-01-19" version="1">MSTWRPGKRVAIAGGGPGAISTALAFIKRGYDVRVFERQTECHAIGGAVLLSIPVLAILRCYGISLENFGSYTSTYFKNKWGKERALLPFNAEVERRMGIKGWQYGVLRSSAFQKMLDLVPEGVIFCSHEVTGYEEVEGEVEVKFKDSNIKPIRADILIAGDGIRSAVSRQAFGDPQLFHTGIRLWLARCDHIPGIPANTGVISHDWQYQASFFPMLHDGKPGFEWWVVEPGWEGKPLPDDPKAHVANILQGWSDPMRQLVEATDFNTQVYRWDIYNRPSMKKWSSGRIVGVGDAVHPVSPYAAYGMGMAIEDGYYLAKALDGVDLRDLRAVNAGFELFERQRVDYVNHHMEFARFLSYVFHNLPWPLAKLRDLVFDYTPFLKTLLQKSYLKKSEDETMHLKELHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRP2</accession>
    <name>A0A8G1VRP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_473743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521048.1">
        <property type="nucleotide sequence ID" value="XM_025662639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRP2"/>
    <dbReference type="GeneID" id="37166041"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="8"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="167"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH63126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="238" mass="26576" checksum="C845BE2937FCA6C0" modified="2022-01-19" version="1">MAGLQVAKRDLRRRMRDALQQIPADSIAHQSRIATNQLLALQEYRDAKRIGVYLSMPAGELSTTAIVQDALANGKEVFVPYIHNLELSSQPKTSVMDMLLLESMDEFRSLEPDKWRIPSLSQASVLNKRNCFGGKGVSPRPEDSTQGPYGLDLIVMPGMAFDEGFRRLGHGKGYYDHFLTRYSKGPESTTTAPKLPLLVALALKEQVLAPTEKIPVADHDWLVDVLMVGDDRCLVRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VS31</accession>
    <name>A0A8G1VS31_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">T. brucei spp.-specific protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_25644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521453.1">
        <property type="nucleotide sequence ID" value="XM_025654985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VS31"/>
    <dbReference type="GeneID" id="37158387"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034604092" description="T. brucei spp.-specific protein" evidence="2">
        <location>
            <begin position="37"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31101" checksum="542882A122826497" modified="2022-01-19" version="1">MACKVIYPKPPLLKTIIHSILFYFLHFFHVPGETEGVVCCSLHLTSFSLWFSSPFSHLTTHQISSSTIPVRSVIYYYPSVYLPFSSFLLLSQLTFSKPLLFHYSISRQSESGSTILRPLGRVLASSGRTNPLRTNLGRASANADGPCLFGSIRSAGCFFLFLFFFSFFFFFTFFSPPPKSVCCLAVGRSHPVLNLRRRAALTILLCLCLWLFPFPHLLPSSRASSASLFYFSSPLPLFFLFFFFFSSLLPLSSSPQPKIPHPSPSLIHPTHILWAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QPF1</accession>
    <name>A0A8G1QPF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-1,6-mannosyltransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_239998</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825093">
        <property type="protein sequence ID" value="RAH51791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509713.1">
        <property type="nucleotide sequence ID" value="XM_025654831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QPF1"/>
    <dbReference type="GeneID" id="37158233"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF5">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH51791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="461" mass="53565" checksum="FBDB846F817AED9D" modified="2022-01-19" version="1">MSLSRSPSPHPAGAGWSSPGLTSPSGPTTPHNGFLSPNPIGASGISWAAAKAKSDEVRGYPSFSTKNSGFFSRSRRQLSATLPRFRLGSGSPNGYVDKDEFGRGRPLSPATGWRLGFGRSVLRRRRSRLLVALIFLLLGYIFFGASLLQKYRRSPLGGGRKFVIILESNIEGGVMEWKGAREWAIERNSVWNKKNYVERWGYELETVNMLAKKRYSHEWRESWEKVDLIRETMRKHPDAEWFWWLDLSTWIMEYSYSLQDHIFDRLDEIIYRDINVYNPLNISHPPDDAYLDEVSRSPTGDGDPSSVHMLLSQDCGGFNLGSFFIRRSLWADRLLDAWWDPVMYEQKHMEWEHKEQDAMEYLYATQPWVRSHVGFLPQRYINSYPQGACGDENDPNVHYQEDERDFLVNMAGCQYGRDCWAEMYQYREISNQLNLTWWERMKDKLNGLYEKLFPGEEQQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QPH8</accession>
    <name>A0A8G1QPH8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C6 finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_215945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825092">
        <property type="protein sequence ID" value="RAH51836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509758.1">
        <property type="nucleotide sequence ID" value="XM_025654648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QPH8"/>
    <dbReference type="GeneID" id="37158050"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH51836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="81767" checksum="F5EBCF9A56759741" modified="2022-01-19" version="1">MNAIVGQELERAEGEVIPQGEDGDLSIPVEHTTAAHKLLSWPSIKALLEPREYDEDYVMKLEEERGLILVYGRGEGHDTSESPAMTFSSSSSSSRSNWDQNYSNGAPASGQWNPGAIQNGTHLKPLGPSIDDFGIFSTDAKTVRRYHQSYLNHMHKLHPFINLTELSASIESFIQKYCLPDVSVPVNILNSHTAGDIPRGAKRKRSCDTLHGAGCDVQFPPGAKHEGSSGRRVEKSLENAIVLLVLALGSICEVQGAIPGPVTDTPVDFQKERIPGPSTRSMLSSADTELVMQSQGSFFSQTSNHSFSPVTGGQKAAPDRSPYPDTSHLRNVDVIPGLAYYAYAAQILGSLQGANGLYHVQAALLAGLYAGQLAHPFQSHGWIYQAARACQVLVRSKRYEQMNDGPLKDLYNFAYWTCLQLESDILAELDLPASGISRAEARIELPKGRTLSLPNDPAAPNTMMMFFYSAQIHLRKVLNRVHTDLYKVEKQNENRWSANVQEILSMNLELWRSSLPDIMRWKDADPPHEDINVARMRAKYYGARYIIHRPLLYWALHHSHPAENGRSASVDSPTGSAMSGAKSQQVSPSMAHSQRAINMARLSSDVGTMGRSAPTPTPVPTISRPALAYRDLNPKLRRACKVCIDSAILSTEAFDGIKGRPVVTNIFGTAHAQFGNMLVLSATYMSSLSELVDRNDLDRLLKRTIRFLLQSREISPTLRADAKILSEIYEKIFGEPADIVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRT1</accession>
    <name>A0A8G1QRT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_482350</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825094">
        <property type="protein sequence ID" value="RAH51736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509658.1">
        <property type="nucleotide sequence ID" value="XM_025663095.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37166497"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="1197"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="1359"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1165"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1301"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1413"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1301"/>
            <end position="1315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH51736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1434" mass="158115" checksum="9A2387788F02F521" modified="2022-01-19" version="1">MDAAEDREVKLQRASGDLVQEFSEKLPSLLWKTRPDQPNTRIPRRWTPAAKTERLVGLLEPFQEWPQLLDPHLQALLPPLVDAFLAYLLKHRDQYASKPAGLQGQKTAYPLPRAICRLLYTFCKVRGVKVISRFLNNEPKYLDPLLRAFVEWDAVKDEPELGLGDIPLRLVWEERYVMLIWLSHLLLAPFDLASMSSDDIPVPYDNLGTLKQMPNRTPVVTKSLLSVALNYINVSGKEREAATIVLARLVLRRDMQALGLLTNLTDWAFSVVQPAGNLEPPSVYTCIGVLSFIARLGASGQVEDFAPLVSPVFGQTLQILQGNSAVSDVIKSSALARKTIIKILRTVTVMALSLSERGDSTISDDQVSTILEDAIDHFLVALADKDTPVRFAASKALSIITLKLDPDMAAEVIEAVTGSLEENILYEKRDGTIVTPLEARRIGINTLKRNLSAVDAQRWQGLILTLGHLLFRRAPPTHQLSDVLQPLISGLDFEQRSSTGSSVGTGVRDASCFGIWALSRKYTTQELLALKPQTISTATAQGEEESTLQMLAIELVCAACVDPSGNIRRGASAALQELIGRHPNTIAEGIPLVQVVDYHAVARRSRAMIDVANATAALSLHYWSPLVESLMHWRGIGSPDVESRRHAAKAIGVLSTQQSYKTMQQVFQRLLNRLSSIPHSDVETRHGCLLAIAATVDAFNAHREGDPIDALDATSVSHYVAKAWEIFGSPLGPTKDDLTLQTFRPELTAEASSQLICSLAQSVTLAREPRISQPSVDLLTKAQDTLLLCISRSEDTSIESSSNAVSELLPLLPPDEQEKMIQGWFSHIQTTWNLPTGRGQITALGTVFKRIDKNSPLRKSIIDSIIECAEKEELIEKRVAAVKSLATGILPHIDVTEDILNHLVRFLNDYTTDRRGDIGSLIRLEAIQAAKTVLEAGPSLPNQLPGVQDIVGCLCRLAAEKLDKVRVQAWICLQGYWETANGFPPLTRKYEHFSHVSSTEYLLQLLQLQSIDCLRQPLFQGLATSAVAGSEGLIRSSRSALVQSIQEAEDPQAAVLAIIKDLAAKLGENLQDDRFAIPVLEVLAFLLDSFVSSVSDDSIPSLRKLFVLVQRAHFKSSNIVRLEAAVRAYAPLSRIEQLQTEVIKKMTALLLHPFPRLIRVIPRALTTNPPTPPPTRVHPTKKHSNNGVHNSAHPDTPQLHVRNLEERIKVDQLKEALEEIFSEYGTVLEIVAKTNLKAKGQAFVVFDTVEAATRAIDEINGFELFDKPMVLDYAKTRSDMTVLREGGEDELEAHKRRRLAEKERKQAHEALEAQKKLKRPPGAPTEPGRPAKTAKGAGLKPTSGAAAAVIPDEYLPPNKILFLRDLPDTADQDSLTAVFGRFEGFQEVRLVPGRKGIAFVEYENESGAISAKEATSGMPMGEAGKPIRVTYQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSI6</accession>
    <name>A0A8G1QSI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_429201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511423.1">
        <property type="nucleotide sequence ID" value="XM_025658240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSI6"/>
    <dbReference type="GeneID" id="37161642"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43167">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43167:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="239" mass="25939" checksum="9DFBCED0477A3B2F" modified="2022-01-19" version="1">MSSPNPVDAPQHVLQLLSELHKKSLEQEATISKNGKFISTAVLGKGPAANPQAELDQLMLDKFIALDEDKCQFTYQLINSMGATNIIEAGTSFGVSTIYLALAVAKTTAATGKSGTVIATEKEKSKADVARGYWHQCGEIVEKQIDLREGDLLETLKEGLPEIDLLLLDIWTPLALPTLKTVLPRLRHGAVVLTDNTISGAQGYADLLSFLRSPENGFRNMTLPFTNGLEMSVYLPQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTQ6</accession>
    <name>A0A8G1QTQ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_453023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511421.1">
        <property type="nucleotide sequence ID" value="XM_025660973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTQ6"/>
    <dbReference type="GeneID" id="37164375"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH53499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="140" mass="15130" checksum="114B8C945A1A8C29" modified="2022-01-19" version="1">MGDGNTFDNKDNTVHNQAGSQVVYGSIYNNTFYAYDQDGARHIAEDKSHLDQKLLEAAAKGETAKVEHLLDNGANVSAADSQGHTVLHVAASGGHADIISILLRRGADKNARTRSNYRPSELARLLGHIPLANKLELNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTY1</accession>
    <name>A0A8G1QTY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_381306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511520.1">
        <property type="nucleotide sequence ID" value="XM_025656411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTY1"/>
    <dbReference type="GeneID" id="37159813"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13298">
        <property type="entry name" value="PH1_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13299">
        <property type="entry name" value="PH2_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="67"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="288"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="402" mass="44982" checksum="A4FA1120903CCDDD" modified="2022-01-19" version="1">MTQPIPTSYAPVAEGNPKAPAIQLPDGTVQTSALLVPNNQSAHYRSGHVNLDTFSPVNENGSFEFDRVLKTGKVFRRVKHKHAFRASWKPAYLVLRPNLLSVYKDEEATRLRASITLSEVTAVASVRSPRSNRQYVFGVFSPSKNYRFQASSEKEAEAWIRHIRSETRMDEDEEAFLALSKNSDTAGNNKRRIYDTTDHSDFDQRGRPSSPEVGDSLSPTYHSRRFASPHDHSGNDITSYSEWSDGPGNNNGVRMTSPSIQNQPASVHSDGPSSIPRNESAVLRDPERVVCNGYLQCLKIKGSMRHWKRLWVVLRPKSLGFYKDEQEYSAVKVIPMAQVIDAAEVDPMSRSKHFCLQIIAEEKSYRLCAPDEESLAKWLGALKSILVARKKLEPAPGAAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUJ2</accession>
    <name>A0A8G1QUJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxylesterase, type B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_463867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510392.1">
        <property type="nucleotide sequence ID" value="XM_025661947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUJ2"/>
    <dbReference type="GeneID" id="37165349"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="43"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="526" mass="58282" checksum="4D80507DF473165C" modified="2022-01-19" version="1">MKLSWNNGALLGSAAIASAEVYPPYYANLTWQPPRTLSNWSNLTVETQTGTFIGMLNDTYPNVRQFLRIPYAKPPVGDLRWMPPQKPEKSRRRYDSTRYGPACPQYVTGESTMWNKYSPPNLLVNLGENLNQGAVAWSTSEDCLSLAVWTPSYANRTSKLPVALFVTGGGGITGGIEIPSQLPSPWVSRSQEHIVVTINYRANIFGNPKSRALNDTSLTLLDVRAAAEWVHENIEAFGGDRDNIMLWGQSQGAALTHLYTLAFPDDPLAVKFGIISQPPSVTIDLSTTDDVYQDFEIVAKALGCNYGDDAEAELECMRQVSWVQIEEYINRYSGSPSIAFSNYIPDEKYIFSNESKRYLDGKVARGPAIRSDAAREDASANTTSVMISEGEWDCRAAQDSALRKSLGLETYRYFWAGNFTNISPVDWLGAFHWSDLLMIFGTYREDVGEVPGLEVKTSETMQDHILAFLKDPSTVNVTVGWPAFDADAPGGGQILEFGEGTPVRKVTGDWLDGGCYNSSIPFRIWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV34</accession>
    <name>A0A8G1QV34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_462920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511443.1">
        <property type="nucleotide sequence ID" value="XM_025661877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV34"/>
    <dbReference type="GeneID" id="37165279"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF31">
        <property type="entry name" value="POLYAMINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="145"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH53521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="661" mass="72616" checksum="879B1D19C90A8718" modified="2022-01-19" version="1">MSPIDEQLEMAEVDARPHTNGASKEEGLERPSSSGTTGSTSYSSSIEYNPQLHTLHSRNTELDLERHRTATSHALSRIETQRLQHQLTVGESVKSRASRAPLPRMGANKDYPPPLPDREDYVVEFDGPEDPLYPQNWKLGTKIYISAILAFTSICSTFDSAIFSSSTTNVARVFGVGIEVATLSSSLYICGYASGPLVWAPLSELKGRKPPILVAMLGFGIFNTAVAVAKDLQTIMICRFFCGVFGSCPLAVVAAVFSDIYNNRTRGVAIAMFSSTVFLGPLLAPFIGGFINSSYLGWRWTAYIPAFMGYAAFVLNMFFLKESYPPIILVSKASELRRRTKNWGIHAKQEEIEVDLRELLVNNFSRPLRLLFGEPLILAVTIYLSFIYGLLYCFLTAYTLVFQGVYGMSAGVGGLTLFGMVVGLFIAASYIIFASRGYNKKLEANGGIPVPEWRLPPVIIGGVLFAAGLFWFGWTGFTKSIHWIVPTLSGLFTGFGLLIIFIQLFNYLIDTYLMFAASAIAANTFCRSLVAASFPLFSRQMFNNMGIQWAATLLGCVASILVPIPVAFYFYGKNLRKRSNSDQSHHICLGNSPRAQAAAATGASGWGIADKTISPSTRSPPHAHLYIIMFLPSLLSVFFKHPITSTFRYPELLPSASDPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVN6</accession>
    <name>A0A8G1QVN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Six-hairpin glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_96167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512625.1">
        <property type="nucleotide sequence ID" value="XM_025665816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVN6"/>
    <dbReference type="GeneID" id="37169218"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034461752" evidence="1">
        <location>
            <begin position="18"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="2">
        <location>
            <begin position="93"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH54703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="679" mass="75808" checksum="5EB40383EACA55F2" modified="2022-01-19" version="1">MWYLQVLALAGVLGASALDADSILSKYFGNDAPWYSDRIPLFETDLTDIQDVYYYRWSIFRAHQRDLGSYGYITTEFLNDVSWQEEPYALLIDASNFHLREGRWCRDRRFTSDYSSFLFGPNGAPYQFSECMADGVWQAYLVNGVADDATPLLSSMQTVYAGWNSTTLGVGGYDTSKDLYWIQPLTDATEYTISSIDASGGEDGFTGGYAFRPSINSYQYANALAIAHIANLTGDTAVCEQYTQLASALKTRLQDDLWNSTFEHFIDRYEEDNEYVTYWDFIRGRELVGYVPWTHDLPDDNTTYANAWTHILNSSQLAGEHGLRTNEPSYQYYMVQYRYDGSNPECQWNGPAWPYQTTQVLTGLANLLDHYPKTAATGVITTADYTSILRQYAQLHYNPARGGVLDIEEDYYSDTGSPIVGLPRSPHYFHSGFVDLILSGYVGIRSRADNVLEVNPQADASAVSYFRAERILYHGHDVAVQWDATGSQYGTVGLVVEVDGETVATSKTLTRLTVELSSASAPEVSRPIAVSVQLAADSEYPRGSVSVADADTDDVHAAIDGRVWFYWIEDVANGWDSPVGNGTEVWYQVEFENATSTASAEIAFFANSTQGYDVPESYRVESTGSTGEWEEVSNANYSSAVANGITTVSWDEVKTEALRLVFTPKTGEMVRLVEWKVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVS1</accession>
    <name>A0A8G1QVS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ThiF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_452431</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesA/MoeB/ThiF family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512486.1">
        <property type="nucleotide sequence ID" value="XM_025660818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVS1"/>
    <dbReference type="GeneID" id="37164220"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061503">
        <property type="term" value="F:tRNA threonylcarbamoyladenosine dehydratase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061504">
        <property type="term" value="P:cyclic threonylcarbamoyladenosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00755">
        <property type="entry name" value="YgdL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000125">
        <property type="entry name" value="tRNA threonylcarbamoyladenosine dehydratase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267:SF2">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="13">
        <location>
            <begin position="103"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH54564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="512" mass="56232" checksum="39C48B58584A7691" modified="2022-01-19" version="1">MASWIQRQSGSHQTQLAATAVISGAAVAGAILGYQALKRKDAVQRLKASIPDVNDQHHVEKLTEYGVAAAAQLSKEDERSALLARRAQEGDYDDELILEQLARNRVFLSDEGLAKLRSSYIIVVGCGGVGSHAVASLARSGVSKIRLIDFDQVTLSSLNRHALATLADVGTPKVHCIRKRLEQITPWVKFDCRNELFGGSVADRLLAPWSWDDNDKGHKPDYVLDCIDNITSKVELLHYCHSHSIPVISAMGAGCKSDPTRVTVGDISLSTDDPLSRSTRRRLKLLGVNTGIPVVFSTEKPGPGKATLLPLNEAEFSKGEVGELSVLPDFRARILPVLGTMPAVFGYTVANHVICDISGYPMDYSVGGKGRDKLYDGVLAALQGTLERLARAEHGPSLVGLRLPISKDDVGYLVDEIFRGKSVVSGLPSRVSLVPWERPERGFGPDPEWMKQGQTFVPLELKDLVCMTKDEAVRHEKEVLLGGKQLEEVYDSKTIEIVQKRQREIEFHEQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWU4</accession>
    <name>A0A8G1QWU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-zeta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_452670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512234.1">
        <property type="nucleotide sequence ID" value="XM_025660878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWU4"/>
    <dbReference type="GeneID" id="37164280"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH54312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="540" mass="58894" checksum="1C87ED6A82195516" modified="2022-01-19" version="1">MSATQLLNPKAESRRRAEALKVNISAGEGLQDVLKSNLGPSGTLKMLVDGAGGIKLTKDGNVLLREMQIQNPTAVMIARAATAQDDITGDGTTSVVLLVGELLKQANRHISEGLHPRVITDGYEIAKNESLKFLEQFKLERTVDRELLLSVARTSLSTKLNSALAEKLTPDIVDAVLAIHRAPEKPDLHMIEIMTMQHRTSSDTRLIRGLALDHGARHPDMPKRVENAFILTLNVSLEYEKSEINSGFYYSSAEQRDKLVESERKFVDAKLKKIVELKQQVCGTDPNKSFVVINQKGIDPLSLDVLVKNGILALRRAKRRNMERLQLICGGTAQNSVEDLTPDVLGWAGLVYEHQLGEEKFTFVEEVKDPKSVTILIKGPNQHTIAQVKDAVRDGLRSVYNTIVDNCVIPGAGSFQVACAAHLTSEAFRKTVKGKAKWGVQAFADALLIIPKTLAANSGHDVQDSLAALQDEQSNGNTVGLDLTTGEPMDPIQEGVFDSFRVLRNCVASSTGIASNLLLCDELLKARQMGRQGGPGGMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWY1</accession>
    <name>A0A8G1QWY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ER membrane protein complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_382899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510807.1">
        <property type="nucleotide sequence ID" value="XM_025656486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWY1"/>
    <dbReference type="GeneID" id="37159888"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034600137" description="ER membrane protein complex subunit 10" evidence="2">
        <location>
            <begin position="26"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22346" checksum="C1AE883F8D815023" modified="2022-01-19" version="1">MRSSYFNFLPALSLFSLSAAISSSSQPQSAEILCWPVASPEPSVLAHVSYDSSTLQPEFTFSSTNIAAACGDNEPQDVSNDLIRLGLYTSTSTNTKQWVGTLASRSSLIGSENDRPTLRLHVGPSNNIYYVDLLPSISSTSSSTPVSPKLELLSSQAGPRPHLNQPIVLGPDGKNAEEVVEKTIFQKYWWVFLIVTFLAMSGGGESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXF4</accession>
    <name>A0A8G1QXF4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_480152</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512579.1">
        <property type="nucleotide sequence ID" value="XM_025662988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXF4"/>
    <dbReference type="GeneID" id="37166390"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="296"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH54657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="628" mass="71788" checksum="CEDD56A573BFCECF" modified="2022-01-19" version="1">MQARVPESSPTPEGDRPVGGNKRKKTTQPANPRPLRRPHQEDLEDRVRKLEELLTRSISTTQHPRNCLSLLEKGHLDTEQSPSLAGSSELPIQTDNPAPSSGLLFGKIHFAGHYVGEIRSYSGIPCFSQSGHEWVQSCTGEPGTFEDVWSHKYPNQVPHLTTPHPQNGYNHSVTPDLPDRSLVEQYVSHFFTSGERMVFPVVDEVLFRDTVELAYRPYQGPPPVEYARARACIFAFLSFIAELDPSPSLPPVDPPVYAAKAQSLLPYILHDVSVPTLQTMVMQAIYRTFTGELQLANQFHSMACRVMFMLGGETGETVDAFRESSKDPQDRKWRSQRMLRRLFWLCYGFDKEICFRSGQPPVIHDEYCDLTLPPNYTEIQYPSTEGNPIRYDDMTIPIFPGDLRLTMLKSKTYRTLYSAKALRKSDAQLLQDIRELDDELEQWRLNVPPGHRPTLGTFQEQHPIPVYRMQPIVIRLEYHYMMCTIHRASGRCEAWGQQWRSCKTGMMEGVNSSMLLAVEASRSSLHFLRTVISSVRPEAFWMIIFYPMSAILTIFCSILANPLDPYVEEDLHLLTVVPDLVRDVRRRRTSDVEIAHMQTVTNFVAELIRLGHCAIEKARRSQRQLTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXH1</accession>
    <name>A0A8G1QXH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylserine decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_471610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511877.1">
        <property type="nucleotide sequence ID" value="XM_025662484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXH1"/>
    <dbReference type="GeneID" id="37165886"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022237">
        <property type="entry name" value="PsiD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF9">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G01730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12588">
        <property type="entry name" value="PSDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-tryptophan decarboxylase PsiD-like" evidence="3">
        <location>
            <begin position="46"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH53955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="443" mass="49631" checksum="446AEED1F50492FA" modified="2022-01-19" version="1">MAPKYKNHTPRLHHLGKWMPSTLDAHHEWLGGVIAHVDSKESHDLHPVIQEFQDLIENNTRVYLLISAMFNELPRNRTYSKDPTGCPQMQDYKHMLRVLNHLITTAPSWNDFSHRVGLVGLPINAVLDWPMGTPSGYAAFLDPDVNRMIKKVLNAWGDFLKSPESAKVLDDSKYGWFGETAKSDLEEVGNVQKTNYSFEELYVCDPSAEHHGFNSWDHFFTRLFREGVRPVASPSDDKVIANACESQPYKVAYDVKARDQFWIKSQPYSVYDMVGCDPLAKQFEGGTVYQAFLSALSYHRWHAPVSGKIVKAYVVDGTYYSEPLFEGIGDPDPSNQHGIDSAGEVMSQEYLTATATRAVIFIECDNPDIGLMAFLGVGMCEVSTCEITVSEGQHVSKGDQIGMFHFGGSTHCLLFRKGVNVQGFPSPKLRHNVPVRSQLAVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXJ4</accession>
    <name>A0A8G1QXJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_159849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511122.1">
        <property type="nucleotide sequence ID" value="XM_025654222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXJ4"/>
    <dbReference type="GeneID" id="37157624"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034454675" evidence="2">
        <location>
            <begin position="17"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="320" mass="34035" checksum="8F74433AABB76427" modified="2022-01-19" version="1">MHTAALFLALSLSAHAVPVFNARGNDTVERREEGPYRVVNVAGPTTPVVETITATNPPAPPTTITVTEYPSSTPASVPGASPSPWNAGPNVGGAPLGRRDTNSSASALSRRAMFEEDAPTNSTVSRRAMFEDAPTNSTASRRGILDDASNSTLSRRAMFEDTPTNSTASRRGILDDASNSTLSRRAMFEDAPTNSTLSRRAIFEDAPTNSTEKHAMAARSNTTSEVLARSLNETAVQTRELKDALVSEHHNASDVSGKFGVMARDTQKSENATDIGSKVAIRARNDTVLQARAFNDTPSDTAVMSSRPHARGLNHTDSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXT5</accession>
    <name>A0A8G1QXT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_79751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513596.1">
        <property type="nucleotide sequence ID" value="XM_025665671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXT5"/>
    <dbReference type="GeneID" id="37169073"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001827">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="173"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH55674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="551" mass="61251" checksum="A36DC8E367F8338E" modified="2022-01-19" version="1">MATASPAPRTPGRTQPSAEVPPVVTDTKDQRRTSSLGFLRRSKSIEILGERRSSGSKNGKKMPKAQTAEEEARRQRESMMYQQPPRLPDLSPAPVLETFGGDERRDTVAALASQPDSSQQQAVPRSTISTPVAPEPSDAYARAESMTHRGRYSYASSAVSTVNNPRRLRRRKDPTPYNVLVVGASNSGKTSFLNFLKKSLELPPHKHPSRLPEEIAYQARQSPANEGYVSHYLETEIDGERVGLTLWDSQGLEKNIVDIQLRGVTGFLESKFEETLSEEMKVVRSPGARDTHIHCTFLILDPVRLDQNIAAAERAAQGTPRATDTPVIGVLDERLDVQVLRTIVGKTTVVPVISKADTITTAHMAYLRKAVWDSLKKANIDPLEILSLDDQEEYTSSESDDEDEEAQGQDTEQDAEASAANEEGAEARSPRSPSQRSQDTRKSSGSQAVVQHIPFTILSPDPHSLRAGDEPVGRKFAWGFADPYNAEHCDFLKLKEAVFNEWRSDLREASRVVWYERWRTSRLNRNVAVASAAPQKKLYAGRTGPDVRRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY10</accession>
    <name>A0A8G1QY10_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_91840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513003.1">
        <property type="nucleotide sequence ID" value="XM_025665788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QY10"/>
    <dbReference type="GeneID" id="37169190"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="885" mass="96691" checksum="8B14030F5E7AA8FB" modified="2022-01-19" version="1">MVKYDIPTLLALSHHGRIDFSKFTEQAVGNNVLRQRKTSTSVLSEQPVNRSRNASNLSRQSERTLSVPEHAVIYPSRQPSDPPQSIRAHADAGFVQFLKEHTSPKHQRVTAGGRIVPMEPQSPTPKAKQPVRNISARANDQKISKPSLRDDTKIKRENKHVLLQDNNARVNISIAAPQPAESHDDIRTILPQSGSAIDQHFSNYGQAPTLLSTAATTGLFSQPSLPWAMSDLPIPQIALPAPEVIPAASDYPMYAFGDGPLSWAPNLYPTLGTQGPVMPSMPAVQPYPAVTTTSHLSAESNTSSGRGTSFLGQLPPTYDSLCPSLGPQWHQYAGGQVPALDQPMIVSTPQTPTYQKSLEDAAKEHESLTSKLSGIDRYMAVHSWDLDPSAKKILVDQRMSLVRELDAVRIYREHLEWVSGRLSTTIPIRQHPSNVASMYVASGLTGSPSLMGPSLCTPSSASALPAFSMLPLANALSQSLSLNETVNASMPLHAVSDTYPYNTTIGSTEVRPNHNSIKDASFSHAARGVEIRIEPKRSDKQVQTHGEAKSRTTDGTAGWKTPTKITALDVEKVHHQIEEATRRGEPLDGLLRELSAATSKLIKQRRGELHEPRGLLAAVPAKHNRKNRAESEAGAVKGLSDKHEAHAPLMRHSTKAWKPGKELRRPGLHSAMGPYMSAKEMEEGDDHQSISSYVSTTDSWATVHQGERRRDKKLRKIKEKRANREMAESRSRGPLEHPHVSNEAFLPGPQRSRGQNLGQPGGPSIYKPRSPPILVNPTDPARQTSVEEMRQRYPQLLTQYFNKDRGLAFQKTAALAVSQNVNAHGFLPPFEGVGNAPSKNRSAPTDMTEGGMYLLSGKMSNSKQHDGPGQRGKEAPGPARQAGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYF3</accession>
    <name>A0A8G1QYF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_450654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513926.1">
        <property type="nucleotide sequence ID" value="XM_025660426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYF3"/>
    <dbReference type="GeneID" id="37163828"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="416" mass="44814" checksum="7DAF3F2ED39CB617" modified="2022-01-19" version="1">MNITTTTTTEPSASSTLPQPDIYTAISLLSISTFTCLLLYYLIFDLSFFPPNPLKAPTTTTLLTTITTTTTTTLLSTTFTILLLFNLPPNNPAVRITSAILLVLTTTTSSISNTLLLYFSLPLITIYQKPYFHLKAQQRILLCGIIASILLFQLPHVIVAPGAATLYKNGHWSHAVTILERISVTAYCGREILLLGCYAWGVVRYLRPAIHDHYQQYHHQYQPHTGHGKGTQLLYTLLMAGCVSLILNIANIVAVYVVHTAAAMAFFPFVVSTKVLVEGVAVGRLVGFVDTSLQYYQQNSIYSVTGCGSQSRRGSAQPLIMQRGSVAMMSGGLGSGVGIGEGKVGGGGGEGEGSPGGTWGREKEQWWYRSRMGSVDTVVSVAEPPVAHSAEHLVQEVVVDLEGGAGVGVSRRTSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYN1</accession>
    <name>A0A8G1QYN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_375181</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513965.1">
        <property type="nucleotide sequence ID" value="XM_025656157.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37159559"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="930"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="992"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1082"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1177"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="398"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="608"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="935"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1267"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1394"/>
            <end position="1413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH56043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1558" mass="172173" checksum="E1FFFD38B53A307C" modified="2022-01-19" version="1">MASIAIGALGILLISSCTVPALLGIIRRFLHVKERPPIQLPGAHPFDRPGYEDKDGEASDEALKGFSDLWKRLGIAILSVTGLGISLAQAILSITKGQHVLIVPFCLQMGSWGVLSVQTIGFFIEPAPTKRYMLGVYGFGASLLAAIIPCLEIGLFWNTGYRLDAVSVGLAISQFGISLFRATLCLLLPRRPNVYHDGQIVDRERTVSAMERFTFSWVNDLLDHAVANEGLEIDDLPKMGFDTRSETLHAHLDRTRGSRALWRSLVVAHQRSLILQSSLSMIICVLSFGPQAAMYGILKSLENRYFNPDKNPKDVDEAWAWVFGLGTVLIISSSIESWLWWIIYAKLWIPIYEGLSALVFAKSMRCKDVKQLVSLDEKEGGDHDADEPQQDVVSQSPINLASVDSKRIADFVMFNYLIPSSVIRLFIGGVFLVHLIGWPSLLAGVATALLVAPMNAYLTKNYSMAQEEYMKASDKRMGAVGEVLHGIRQIKFAALEQQWQDRISEKRRVELGLLWQASLYTIGMVSVWIMGPLMLSAVSLTVYTLTRGELSASVAFTTLSIFGSLESAMASLPDLLSKGMEAKISADRIERYLGSSEKSPHTSAVDKISFHNATIAWPGEEGAEFDQRFLLRDLTLQFPPKGLSVISGKTGSGKSLLLASILGECDVLSGTVAVPHAPSINRTYDQRATRHNWIIDSAIAYVAQNPWLENATIKDNILFGLPYDRYRYRKVIYAAGLKKDIAMFPDADRTDIGANGINLSGGQRWRISFARALYSRAGILVMDDIFSALDAETGRHVYEHALIGKLGHGRTRILVTHHLGLCLSRTDYCVILSDGLTIHAGTVDELAATQNLIDLLGESAKSSNDRNADVVDDEPVTPITPMKRVSTESGFSVATSVAEPPRKFTEDERREKGAVSLQVYTTYITKGKCLRWWTITFLAYVAFMTLLVGRSWWISVWTDSSTSSSQPAHSSAAIQSRTIDVNRRFVDKDSMFYLSIYVCFSVAACIIGTLRTLALALASLESSQRLFDDLLAAVLRSPLRWLDTVPLGRILNRFTSDMYILDWRLGYDIGHFVFKALELTSILAAGVLVSPILLVLACILLILCFRLSKIYLTGMRQIKRLESTAKSPVLERFGSSLSGLTTIRAFNKADIYLKDMYDRIDRHAQAAWYLWLLDRWLSFRMSIAGAVLAGMTAALVVYVPSISPALAGFAMTFALQYNYAVSMGLRFYANVETDMNATERVLEYCNIELEEQGGHNPPAAWPTRGKVEVEDLVVGYAPDLPPVIDGLSFTMENNQRVGVVGRTGAGKSSLTLALFRFLEARQGRILIDGLDISQIKLEALRSRLAIIPQDPVLFSGTLRSNLDPFNEYSDVELYNALERVHLVSFEDTLTLASHSSSEPLSDSGTLPSSANSSTEPLKTSNFFASLSSVVSQGGLNLSQGQRQLLCLARAIVSQPKIMILDEATSAVDMETETLIQRSIREEFGRNATSLLVIAHRLSTVADFDRILVMDAGKAVEFGTPQELLDIEGGVFRNLVEHSGERAHLERVIKREETRSRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZM3</accession>
    <name>A0A8G1QZM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_449370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515263.1">
        <property type="nucleotide sequence ID" value="XM_025660150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZM3"/>
    <dbReference type="GeneID" id="37163552"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH57341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="760" mass="84404" checksum="3162C7FBBF1C3975" modified="2022-01-19" version="1">MSGTGDGAAYNSNPDIATQDSREHRPPVRRRKTRLACNNCRNHKTRCDGRTPACSRCANRGLGQSCIYEKGSLRTQRFSWLCLFSIDYIADTRRYVLTLEDRVRELQRSNQRGSHRRSGGDIYADLTPGRRLDPNSSSNVVDHLVVSTPPPSDRYLDTQLLAQQDALPTSQNDFICTDATVIVPSPETDSAYASGTSSVMGLVQSMMRAAGTSNQSNHAPRLDFGQNMESSSGSKRVRRTPGDSHDVDIDLPSLPPRRVADNLMNCFWNSTHPIFPILHKPTFVASYELLWAPDDDQASLPESGATEDPIFLASLNAVFAIGCHFSDIVAPAKRATLADQFYQKSRKFYQVDVLDFASLSTVQMLLLTGLYLQSTKYASRCWNIFGLAIRSAYDIGLHIDSPISASRGPLEREMRRRVWHNCVVIDRLLGLTFGRPSMISKKSSVPAPLMVDDAYLLESGEENQLRQLQCRDGFFIYSIQLFDILDDIISKVYDHNGVATASNVNGIWGSRQRLEDILKLNSALDDLDASLPSNLGSGCTTEVDRDLRNTGGNLQARVFYSRFLYIRILLLRPVLLSAAQNRNTLSECAGNRKNLRLEDSFALDACRLCVSTVHTLIAHLDESLADVSRSPGWRIVHYAFVCAIVLLISRLCPIPGTEFSSSSLEDSVSRCIMILEHHSVQVQSATQAMKVIEALQCRVAAMNESANEGVNSNNLSSQDDNILNLNSPNGFSQFHGDATNLLSETWLAEHVGDMNCWNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R048</accession>
    <name>A0A8G1R048_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_40374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514669.1">
        <property type="nucleotide sequence ID" value="XM_025657241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R048"/>
    <dbReference type="GeneID" id="37160643"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="106" mass="11964" checksum="1A7BE0AD2C826403" modified="2022-01-19" version="1">MYIACGIGCVSWCIVLFASVCFLFFFGPFQGVHRLQCLRIALEVGVCNRCMVFVSGWNVIYVKHYFVKRPGFTTPFVSIPVGRTGWESTLPLMIDMLIISIIKLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0W8</accession>
    <name>A0A8G1R0W8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_51520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514409.1">
        <property type="nucleotide sequence ID" value="XM_025664769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0W8"/>
    <dbReference type="GeneID" id="37168171"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH56487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="161" mass="18370" checksum="B117F3B87F4307A8" modified="2022-01-19" version="1">MVSKDNLCQNILVWTWRSRCMDFLAWPPPYQRHTTVIRLYQSGEDLSRAPDMFRDHRLSGQKAGELVRLVSRSLAWRTEGQSCRSRRKKEDPPSSRLPCGDGGELAIGHQVPQSLIIRFQANATLSFIYISARYCARHIYSAKPSLFMTAKTTSTIPSPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R189</accession>
    <name>A0A8G1R189_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SET domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_460007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515224.1">
        <property type="nucleotide sequence ID" value="XM_025661690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R189"/>
    <dbReference type="GeneID" id="37165092"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000039">
        <property type="entry name" value="SET domain protein (AFU_orthologue AFUA_4G11040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF135">
        <property type="entry name" value="SET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G11040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="673" mass="75272" checksum="2955402C1A3075F3" modified="2022-01-19" version="1">MVDNGGHLHESVQIAKDESRGVHLQVKKDWKDAVPTDTHIIKTPLATTMSYFNVVNQSTPSISFSAHGLHFPQSFIDAVGEKESTIFFLIGQYLRGTEGFWYPYIRTLPQPGSLTTPPYYDGEDLQWLDGTSLLAAREKRLEVLKEKYEKGSTALRNAGFEGADAYTWDLYLWAASMFISRAFSARVLSGVFPETDLSEEKLSVLLPIIDMGNHRPLAKVEWRAGKDDVAFVVLEDVSAGQEISNNYGPRNNEQLMMNYGFCIPGNPCDHRIVSLRAPPGSPLYMAKSHQLQMYPDLAVGEPEDHYYVFNVFYPLLAPDMSMEHSIFSPALLDAVSVLAANNRELETLEITNQGIKIPHVYGNSRALLAALSQVIIEVITHAAKLRASGEDLQTPTNLKQTHAKVYRDSQIMLSETALVVAAWTLNRARLHNFTGTWEETKRVLGAHMGRIPTGKFPEEVYSRLQVRILERKSLLTNNGELFTLGELPDLLPTAMQQPCKACFQDILSVSESAIPMLRGSGGSSPFAFPMFLCLVAAAHTASKSGASEEFKPSPRLSRWASFLLENYPPPPNDVAWALEDEDDEHIVSLFDETLEKMRSQNAGVFTSLAPYTGDWQKDDWWLSPNWLRWGWMIGEQECVQIPDDPLQLLATGSGGQVRLMTENYLYVPGEAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1J3</accession>
    <name>A0A8G1R1J3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_470569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513147.1">
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        </location>
    </feature>
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        <location>
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            <end position="237"/>
        </location>
    </feature>
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        <location>
            <begin position="286"/>
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        </location>
    </feature>
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        <location>
            <begin position="420"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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            <begin position="22"/>
            <end position="37"/>
        </location>
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        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
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        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
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        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
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        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
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        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
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        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
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        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RAH55225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="647" mass="68706" checksum="DC5A6154F2CEE98F" modified="2022-01-19" version="1">MTSSSNPSTLSHSRAIPFASRLSEQLSQRTAQTSSGTDPDHAGDRNTPTLGPPLRPSPNTRSLSDAGKPVSAMPINHDDSRPPSKDDSSLSSTPETPQRPSMQSLSLNLSARSSGPLSLSNRAPLSPKLDSSAIYGSPGSVLPRRSRGLDFSRACTNLHHSTLAEASPDSSPTVGGRGVNIPQRRGSPASVSGLQFSTSNPADKATISSSVSSVNMMESDTSSSEEDDEPMIGDRDDMMITNTPQAKRLGGGMSPFAVGNVSSPGNEWMGGYSQAAASLMSFQRARFRKGRSRHSSSSASGSSKQSPGPLSPPVMKSIEGQNGGYFGAGARRASLSMGTRDLRLSDVSDEGENRGARGQSPSTSNSEGGPLGVIRRAVTRRGSLLPKTKTFARIRAALMEESAPIDSEAKREAEVIRQVKENEPDVEAKSPLGDLSALDTSTPVAHGQTPEEIPPKAGLTTPDEPKFIDQANRNSGGVEFWNSFDERYRTPPPPQRRHGASSVSEDDLAMDITPSTTVGSTTEFAKPSERPGSRSEASQGAPAGFVGEFRRKRRRDDDFDPNLFKRRAVSPSMSAQSSPVMPNSPVVKDTSPSIWGPPRSNLGSLFPDRPVTENGPRNGNNHTGTLKRVGLHGMNETSDGFMNMSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1M5</accession>
    <name>A0A8G1R1M5_9EURO</name>
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        </submittedName>
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    </gene>
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        <name type="scientific">Aspergillus piperis CBS 112811</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
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                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="RefSeq" id="XP_025515449.1">
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    </dbReference>
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    <dbReference type="GeneID" id="37158769"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="129" mass="14527" checksum="5B3E182DC6E90D27" modified="2022-01-19" version="1">MMMIELLSCFDDEVSLSHSQISRSFSFFGSVTRSFQFPSPYYCCNPYFDILGPFSRRWRCICVSVCLLALSLSVQKQALGRILYIHPRNSRSNASLCSAMLCFVARGGRGLALSSLFYLPIFSSPLLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2E1</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">BO85DRAFT_36567</name>
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        <name type="scientific">Aspergillus piperis CBS 112811</name>
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        <lineage>
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            <taxon>Eurotiales</taxon>
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        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J."/>
                <person name="Theobald S."/>
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                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
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                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
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                <person name="Salamov A."/>
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                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="37159150"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="62" mass="7040" checksum="06DF900C093D0B13" modified="2022-01-19" version="1">MCLSDCAVPVNRWHALGSYAVAIGIGIGWIGMHIDNMLWNSHYRDVYSCSIPRRDNFRVIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2J4</accession>
    <name>A0A8G1R2J4_9EURO</name>
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        <recommendedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">BO85DRAFT_373411</name>
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                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
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                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="37159481"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="210"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="417" mass="47233" checksum="16809884F34ECF94" modified="2022-01-19" version="1">MGMTGAGKSTFISLVTDQEVVIGNDLNACTQNVTMYRCKFSTSCNIWLIDTPGFDDTSRTDSEVLKEIAGWLAESFSQKVLLNGILYLHRIMDNRMPGSAKRNLFMLKKLCGKDALRNTILVTTMWDCVDPADGDRREKQLITTPEYWGDMIAAGSQTLRHDNTYESAMRLINLYAGSHSTKEKKVLAIQHEMVIEKKALDETDAGKAVEDALIKERSRWRRELDDLREMMKEVLAEKDKESAEMLRQNTAEINAKLAAAERAQRDLKVTMEQMHRERLSAFRRDIEAQRKENKIIREKLSTFEASRDRKAKESSIAPVNSQTLSPLSEELEAQNSKLGAAQAHVQEMEKAHDQGSLDMRGPKYASLLEQLEQHRRELLIVQSSIRGMGQGHGQRYGCDLEPMYSGKLLAQLEGLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2Q6</accession>
    <name>A0A8G1R2Q6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_66376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513732.1">
        <property type="nucleotide sequence ID" value="XM_025665574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2Q6"/>
    <dbReference type="GeneID" id="37168976"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="332" mass="36409" checksum="11911C1D92495358" modified="2022-01-19" version="1">MFEDFSFSSPSSTRPSRLALDGDDRLMVDSDSSLISPMSSRCPSPRSHRFPRTASRSRSSYFRSAQQPPTSVPFSAYDHKRLSISTLTRKLHEHTLQNPNGLQPEEAGRFDRPASPTPSDLGISSKFPGYVLTPPDTDHDDESLTSGSLSPQSCSPFLSPTSVPADFPAADNIDLNGNATTAAPSSDAWTVRAQRQQISRLQCNQSDVEAIRRALVSDDEIMRSAICRDSICEEDYHPSSLPPQTSPRRRALTLSRNRFRGQASSAASAESAGPETRARRKSSVSALASSHRIEKSYHCSSRDMHKKNEQGLRRKSLVSAALASMVEQGPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R302</accession>
    <name>A0A8G1R302_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_278472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516555.1">
        <property type="nucleotide sequence ID" value="XM_025655164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R302"/>
    <dbReference type="GeneID" id="37158566"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="164" mass="17626" checksum="4D25AFA1070BAF6B" modified="2022-01-19" version="1">MQSFQLISPHPANGIVAPVGCSSVILIRSLGARMRLCRNPSTACKTWLNSGLAVKGNQPSEGLVHRPLRSCTGPCRHGNGRPGRCDLGTRGTGSQMTVHRIGAANCADHETRQQLGVVARRLVGSVSLQHPGPINLIQFSSPSPGSDGWVWWIALPSFHCMLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R349</accession>
    <name>A0A8G1R349_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_369675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516305.1">
        <property type="nucleotide sequence ID" value="XM_025655932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R349"/>
    <dbReference type="GeneID" id="37159334"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="668"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="889" mass="96787" checksum="6BBB267AC5A21D1C" modified="2022-01-19" version="1">MAAPPGKSTAQAAKPVTSSTPTSNVSARLEKTHPGVRRSTPDSEALASSDDDGDHSQHVATSTSMPAPKPARRTSWLNEIPATATRKASLTTSGPLSTGASNPSSPATDQSGWTNTSPGIGSSIPWNHVGNPSFPWGTGIWNTESRKEPPPRLAEIVPSPTMSNPSTAGNYFTEEILSPTTRTTAGESAIPFSIPLHPTPKTYRSQSYSVGQLDPEFLSFMANKSSTPYSGGRPRNGSQFSALQHRSSRPSLLGELGHDPATLGRVREDDDDDAGSPDGSDGSFSNYAANQARTIEQLSRENALLRQAAGQMDNPMRDRTMSSASAASGYAIGSGIHNLHRIRGSVPEETDLAVEDLDEVGDIPGYNNIHSSGRRRLSEHSANLEKQLPPYTSFQNRTLENVRKAHWQTSLDFGSIADIPQSRRHSFADIPMRHASVSGETQAAPSTRAGMSDREEDYASIVDGPLSNVQGQNREYPRFHVAPRPEEHEMETEYLRARRFAEAYFARDPVLRAADGPASMATSLHQAYTMPNAYGRHQPGLAHSHQNQLLYIVTFKCHRADVFYIQEDTGLQVKPGDLVIVEADRGTDLGTIQHANVSMQRARELKQQYAEEHYKCLMMFSRQGQNGAVNVVNASSGVPGLNNRSAIGGMGPHGPHGMQDSAADIKPKLIKRLAQNHEILTLREKEGNEAKAKRVCQQKVTEHRLNMEILDAEFQMDWKKLTFYYFADSYINFNSLVTDLFKIYKTRIWMSAINPASFVTPPSAGLSAPNPLAYNHDAQADRPLDGRIYGHPRDAMGTGRDIGANQMGILRNAYADSYQPFSPTSRQTELGGLAAVDPFSPYSANNYGSLESGYVDYGAGAGASSGPSRLHAAPSEWINNRFQGLSLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R380</accession>
    <name>A0A8G1R380_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xylanase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_459501</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515356.1">
        <property type="nucleotide sequence ID" value="XM_025661662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R380"/>
    <dbReference type="GeneID" id="37165064"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18827">
        <property type="entry name" value="GH43_XlnD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052176">
        <property type="entry name" value="Glycosyl_Hydrlase_43_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0858">Xylan degradation</keyword>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="6">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH57434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="329" mass="36412" checksum="761EEEC5B6152ED4" modified="2022-01-19" version="1">MSYPQQPLPQNLLTTTTSSVTKAGNPVFPGWYADPEARLFNAQYWIYPTYSADYSEQTFFDAFSSPDLLTWTKHPTILNITNIPWSTNRAAWAPSVGRKLRSSASAAAAAADEEYDYFMYFSVGDGTGIGVAKSTTGKPEGPYEDVLGEPLVNGTVYGAEAIDAQIFQDDDDGRNWLYFGGWSHAVVVELGEDMVSLKGEYLEITPEGYVEGPWMLKRNGVYYYMFSVGGWGDNSYGVSYVTADSPTGPFSSTPKKILQGNDAVGTSTGHNSVFTPDGQDYYIVYHRRYVNDTARDHRVVCIDRMYFDEDGEILPVNITVDGVEGRTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3E4</accession>
    <name>A0A8G1R3E4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_449766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514952.1">
        <property type="nucleotide sequence ID" value="XM_025660227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3E4"/>
    <dbReference type="GeneID" id="37163629"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF36">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH57030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="346" mass="36296" checksum="B24A9BCD05DA0FEB" modified="2022-01-19" version="1">MSLQTPLCSLLKIQHPVLLAGMARASGAPLAAAVSNAGGLGTVGGLGYTPEQLSEILTDLKSLLKDPSLPFGVDLALPQVGGGARATNHDYTHGQLDQLIDVVISHGAKLFVCAVGVPPERVIKRLHDAGILIMNMVGAPKHAEKAFKLGVDIVCAQGGEGGGHTGDIPFSVLVPAVVDVARKYKSPLTGQPALVVAAGGVNDGRSLAAALMLGAAGVWVGTRFVASEESGASRLHKEAVVGAQYGETKRTLVISGRPLRMLPNEYIKEWEKRPEDIARLTAQGIVPIEHDFKNDKDVDVPFLMGDVSAIIQEIKPAGVIVREMVQQAVDMLKKGGSYINGPPSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R478</accession>
    <name>A0A8G1R478_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_290249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515881.1">
        <property type="nucleotide sequence ID" value="XM_025655258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R478"/>
    <dbReference type="GeneID" id="37158660"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034133945" evidence="2">
        <location>
            <begin position="19"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="144" mass="15264" checksum="D0B4F71E2E7A1509" modified="2022-01-19" version="1">MKASAVLSLVALAGLTIAAPAVGNGNVHGSGSGDIHKRGDGWGEKPEAVAVEEVAVPVAVKKPQEHWHKPQPVPVKSDEYSKEAGKKWGKEGGSAGEEHYKSIQDNESASFSKSFGETTDDKKGKNWGKEGGEEKEKEKGKSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4K3</accession>
    <name>A0A8G1R4K3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_447828</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="4">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517888.1">
        <property type="nucleotide sequence ID" value="XM_025659792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4K3"/>
    <dbReference type="GeneID" id="37163194"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000005">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0041">Annexin</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH59966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="443" mass="49426" checksum="AC1486347366D48D" modified="2022-01-19" version="1">MYPHQNRPPYPQFTGPPQGYGQQQNPSPFPPQNQHHMASPPYPNQPGYPPYGAPHPNQPPYPHTPQGAPPGRPEMYHGGPQGYSQGLPPPQGAPHGPPLGMPHGSFGAAPPLPPHPQSYPPLASVPSLGYVRGQQANGDFRPQADQLRRAMKGFGTDEKTLIQVLAKLDPLQMAAVRSTYTHHVRRDLYKDVKGETSGYFRRGLLAIIDGPLQYDVACAREAVEGIGTKEWLLNDILLSRSNADMNAIKAAYHQTYHRALEKDVEGDLSFKTRNLFTLVLRATRHEESAPLDPQLIEAEAKSLHQATAARMVNNVDEVCGIIARASDNELRALNHAFYTRYNIQLTKHIEKEFSGHMKDALLHMLGAALDPAMHDAEQLEDCMKGMGTKDEKLVTRVVRLHWAPGHLDQVKRAYRHRFQKDLIERVRGETSGDYQRLMVALLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5P6</accession>
    <name>A0A8G1R5P6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_447141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518488.1">
        <property type="nucleotide sequence ID" value="XM_025659657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5P6"/>
    <dbReference type="GeneID" id="37163059"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH60566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="326" mass="37659" checksum="D618859F4ACB077C" modified="2022-01-19" version="1">MPSNNIAEQLESLWKELVVKTPEVLVDKENQVSDLVLDEYLIDRSHMGPYSLEDLENEDQGTTGADIYGPQTLFPAEAPIHFQPMSRAELEKYPILPSEQPRMRDYDPAIADESPNAQKNRIYQWAYHLLKWVSYSVSQCGVRENANTLDERLHRRRKLKNIHWPDPFYLGCKLFGAYPSVHDHWGAILRIEPDKIDGHRIYPHLTIGLALSHCGNESSMLYEELAVIISAMKCRALQPRVPEDKALFEEDIETIKSMPREFGDEKTFPLLLLSFPGPQNFRYFQVCMRGIRMLILQSKLYSFEKKETAPIELLVRLAMSQPLSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R633</accession>
    <name>A0A8G1R633_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_447939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516841.1">
        <property type="nucleotide sequence ID" value="XM_025659817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R633"/>
    <dbReference type="GeneID" id="37163219"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055560">
        <property type="entry name" value="DUF7136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23584">
        <property type="entry name" value="DUF7136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034120574" description="DUF7136 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7136" evidence="2">
        <location>
            <begin position="28"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="285" mass="30180" checksum="F065FEF86927603B" modified="2022-01-19" version="1">MNRRRFLAWAVLVLNSIIAMGDGTPDISPGIFEVDLIFPRNETYTPQALMPIVFALQNPSLASTLGATVYWGLREGNNWSAPGSITDGGFELFTLNSTSSGPHLATSFVNTLAYPDGSWTFAWTLEVTNCSQAERPDCLQSESQNCSLTYNPNKVISLNNAIVFNVSQSGQTPSLEAATSSDMCGTMEAFAFNVTSAGDTEEVCGFLGPSPTTNPCATTVNASAASSIWAEATAFACDPRERSAYPNVTCPTSSSKSNAARQSGMAAASTLLTLLTMGTAFIHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6L6</accession>
    <name>A0A8G1R6L6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_459716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515652.1">
        <property type="nucleotide sequence ID" value="XM_025661670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6L6"/>
    <dbReference type="GeneID" id="37165072"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.580">
        <property type="entry name" value="GXWXG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025568">
        <property type="entry name" value="DUF4334"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025951">
        <property type="entry name" value="GXWXG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14232">
        <property type="entry name" value="DUF4334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14231">
        <property type="entry name" value="GXWXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GXWXG" evidence="1">
        <location>
            <begin position="49"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4334" evidence="2">
        <location>
            <begin position="115"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="169" mass="19467" checksum="912F184103EC6307" modified="2022-01-19" version="1">MLPNITFKQGNTCPTILTHISHRPVEEYPLCLITKQKSFHSSELQNVSDHLEAVKSEALLGKWELHLLRTGHPSESVAERLLPLTKIVHSNTSVTKYSLDGETKKFLPDWGEMFLLEIAYRGLCSMAMIYDDHPRIDYLRYVNKHIIAGAHWPRKEDEAGVLYFYLTKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8D9</accession>
    <name>A0A8G1R8D9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_447625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517682.1">
        <property type="nucleotide sequence ID" value="XM_025659760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8D9"/>
    <dbReference type="GeneID" id="37163162"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="71" mass="7636" checksum="5A1EC19F12335846" modified="2022-01-19" version="1">MVPSKCIKELYVSPFNSLEGEYSISTIDHLATISGEPPLNSRISLMTPEGKIKMVASIRSKGPGIKLSALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8K5</accession>
    <name>A0A8G1R8K5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_466490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519094.1">
        <property type="nucleotide sequence ID" value="XM_025662131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8K5"/>
    <dbReference type="GeneID" id="37165533"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="326" mass="35270" checksum="84CAE26B90A46929" modified="2022-01-19" version="1">MAPALGQIFPPNPTFVEKDMPDLTGKVTIVTGATSGVGFNTASILYSKNATVYIAARSADKARTAINEIQTSTEGAHSRGRLSFLKLDLSDLASIKESANRFLEQEDRLDILIHNAGVMTPPAGSKTITGHDLEMGTNCLGPFLFNKFLLPLIQRTAATAPAGSVRVVWLSSMLASFAATGGIIFDDESDSPKVLSDAMQNYMESKVGNMFIAKEMAKRYGGDGILSLSVHPGLMKTELQRHNSAIQSTVMGWIFKGPRYGAYSELFAALSPEVTKEKNGAYIIPWGRFGPIPCHLQKALVSKRDGGAGTAERFWAWCEKETAPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8P4</accession>
    <name>A0A8G1R8P4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_396097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516732.1">
        <property type="nucleotide sequence ID" value="XM_025656986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8P4"/>
    <dbReference type="GeneID" id="37160388"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF34">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034608983" evidence="5">
        <location>
            <begin position="18"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="94"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH58810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="529" mass="56982" checksum="D9E2B1DFB815162E" modified="2022-01-19" version="1">MRPGALFIATLLARVTALDNTTSRIVAKLASYGVDAYEYFNSSVLLDSSLSTRSLGFCSDLCSALPRLYPGHVLQRSTTAYSTWDASFWSQQQEDVDPACVFQPSSAVEVAVGLLLSELTLCPFAVKSGGHAAFAGASNIQDGLTIDLVGLNSTALSRNSTVASVGTGNRWLDVYDWLDPMGLSVIGGRVSDIGVGGLTLGGGISFFSGFHGWACDNVANYEVVLADGSIVDVNPDTHSDLYWALRGGGNNFGIVTRFDLTTHTQGLMWGGSRVWLEEYQSDILHALVDFGFNSPSDPNGALIVSVAYAEGLYLLVADLEYAQPVTNPPIFENFSSSGVLEDTMAIRSLSNITLLFKESNPNGLRESYWTGTVQLDYELATNITNMFKQELVPIQNVTGLVPALVWQVISTNTMEHMAKNGGNALGLDPEDGPLLLINLAFMWDNEADDAAVMAVLGRVTQKALSAAQARGLGSRYLYMNYASQYQSVVPSYGTANQARLQAISKKYDPLQVFQNLQPGYFKLDGAPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8Q9</accession>
    <name>A0A8G1R8Q9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_475364</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519169.1">
        <property type="nucleotide sequence ID" value="XM_025662718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8Q9"/>
    <dbReference type="GeneID" id="37166120"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015113">
        <property type="term" value="F:nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000382">
        <property type="entry name" value="Nitrate transporter CrnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004737">
        <property type="entry name" value="NO3_transporter_NarK/NarU-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00886">
        <property type="entry name" value="2A0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="35"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH61247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="504" mass="54249" checksum="DB88DAA7065CA5BB" modified="2022-01-19" version="1">MDHIKLLFVSPEINPSNRKAQSIPILNPFDKYGRVFFFSWLGFMVAFLSWYAFPPLLTDTIRQDLNMTETQVANSNIVALLATLLVRFVAGPLCDKFGPRLVFIGLLLCGSIPTAMAGLVTTPNGLIALRFFVGILGGTFVPCQVWCTGFFDKKIVGTANALAGGWGNAGGGITFFVMPAVYDSLVKVQGLPPHKAWRVAYIVPFIIIVGVALTMLFVCEDTPTGKWSERHLWVKEATESEGNIIDINSGIPSKAPSVSDMMADVEKKGGAQTPMSLGAESQQIGQFDALRTDTVVAPTRKEALNVLFSMFTAAVAIPYACTFGAELAIESVLANYYVANFPSMGQTESGRWAAMFGLLNIICRPAGGFVADFLYRTTQSLWSKKILLVSLGLITGAFQLAIGLTNPKTEATMFGLMAGLAFFLEACNGAIFSLVPHVYPFANGVVSGAVGGMGNFGGIIFAIIFRYNGSHYAQSLWIIGAISLAANVGISWIRPVAKNPVVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8S3</accession>
    <name>A0A8G1R8S3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO85DRAFT_232747</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 19">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518504.1">
        <property type="nucleotide sequence ID" value="XM_025654786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8S3"/>
    <dbReference type="GeneID" id="37158188"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF108">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="7 19 20" id="KW-0349">Heme</keyword>
    <keyword evidence="15 19 20" id="KW-0408">Iron</keyword>
    <keyword evidence="10 19 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 20" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="14 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="19">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RAH60582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="467" mass="51979" checksum="941CA349DE5D2AFB" modified="2022-01-19" version="1">MPSPIPKPPGVFLLGNVKDVNAANPWNSFNKLAAKYRPICKVTILGVDIVLITGAALLEEICDETRFQKCVAGPIIEIREAVHSSLFTAKINEKEMSQWGVAHRIMAPLLTPGAVDQVFADMREVSTDLIKKWTAGPRQRVSVTNDLDRLNHAANMLCFFDQRLHCLEGPEPSLIKAMENATTEAVRRASRLKLVNWLFYQRKFNAYNNTLRKYSASCVEYRRAHPSAKKDMLYALMEGKDPETGEGLNDEQIVDEIINVFIGSATAPNLVAFGLYYLMKNPHVIKRAREEIDAVVGGPGAKIEHEHLSRLPYCLAIAQETMRLAAPAPGFNREAIQDQDGPVLLAGGEYEVPRKQALIAVLYGVNRDPAVFEDPDAFKPERMMGEAYEKLPSAVKKGFGNGKRVCIGKKYAWEWSYFTLVSILKDVEFELADKNYVTDGAGNNYNGAFTVKPLDFFAITGPRPRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8W7</accession>
    <name>A0A8G1R8W7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_447873</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH60015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517937.1">
        <property type="nucleotide sequence ID" value="XM_025659802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8W7"/>
    <dbReference type="GeneID" id="37163204"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03700">
        <property type="entry name" value="EF2_snRNP_like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH60015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="844" mass="93646" checksum="E72353B84F611E6D" modified="2022-01-19" version="1">MVNFTIEEIRGLMDRPANIRNMSVIAHVDHGKSTLSDSLVQRAGIISAAKAGEGRYMDTRPDEQDRGITIKSTAISLYAKFPDEEDLKEIPQKVDGSEFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQALTERIKPVLIINKVDRALLELQVSKEDLYQSFSRTIESVNVIIATYFDKALGDVQVYAEKGTVAFGSGLHGWAFTVRQFAVKFAKKFGVDRKKMLERLWGDNYFNPATKKWTKSQPEVNGKPVERAFNMFVLDPIFKIFQTINNDKKDQIPTLLEKLEVKLSNDEKDLAGKQLLKAVMRKFLPAADAMLEMICIHLPSPVTAQKYRGETLYEGPSDDDCAVGIRDCDPKAPLMLYVSKMVPTSDKGRFYAFGRVYSGTVRSGLKVRIQGPNYVPGKKEDLFVKNIQRTILMMGRFVEPIEDVPAGNIVGLVGVDQFLLKSGTLTTSETAHNMKVMKFSVSPVVQRSVEVKNAQDLPKLVEGLKRLSKSDPCVLTMINESGEHVVAGAGELHLEICLKDLEEDHAGVPLRISDPVVSYRETVAGTSSMTALSKSPNKHNRLYLTAQPLDEEVSLAIEAGKITPRDDFKARARLLADEYGWDVTDARKIWCFGPDTTGANLLVDQTKAVQYLNEIKDSFVSGFQWATREGPIAEEPMRSIRFNILDVTLHADAIHRGGGQIIPTARRVLYAATMLADPGILEPIFNVEIQVPEQAMGGIYGVLTRRRGHVYTEEQRPGTPLFNVKAYLPVNESFGFPGELRQATGGQAFPQSVFDHWSVLPGGSPLDPTSKPGQVVTEMRKRKGLKEQVPGYENYYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R902</accession>
    <name>A0A8G1R902_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitrogen regulatory protein OTam</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_436325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518609.1">
        <property type="nucleotide sequence ID" value="XM_025658572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R902"/>
    <dbReference type="GeneID" id="37161974"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="78"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="692"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="703"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH60687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="730" mass="80227" checksum="6DA9875F6EB97126" modified="2022-01-19" version="1">MAAVITLQSSSTTGPTAPSAAAFQQSPASDHHHHQLLRPRVQQQSQPQPSHAPQPGSISTPQSPASSIGTLPRVTAAGRDAPSCDACVRRKSRCAINEMINKCYSCDFHRQDCTFTLSVTSRPGTADVTSKKRKLDDADAEEVESPKRQSTTLPPASNNPDSSSRPTLNNNHILTPAFWFQSTQHIGLTTELEPALLEFLPLDQNNEGCVASSRVRKFGDDGTFMRVVNTRSHADSPQTATLDAIESLVAPYGSTLVEKFFEHVHPSFPILMEDSFRQSYRARTGLTPLLLSAVYVLALKFVDVGSASQSVRRPDAGRLESTALKLLTESLPYASMSTVQAGLLLMQRSNLATAALNAQLVTAGFELGLHQDCSNWRMETWEKGLRKRLAWALYMQDKWSALVHGRPSHIVSSNWMVQDLVEQDFTDAFSGTSAHDDAPVGHGPLSFCHMVALTTILSDILDRFYTLQAIEEFRTAGNNRTRMILERAKPAQIRLKEWFGRLPTQLKMDSGGDIFETVNEDNSRNGALHLAYFATEITLHRCIVRSLSQDTADAYLSHICRSAAKTRLISAMDFVNRLRPMHLRSFWPAAARTNFALIGSFGVLLRVTAPTKEESEFYRLRLCEYRWTLSVSKKDAEFLEFALESLDSATNLDHYVPEKPGIDELMTSAAKPTINASRSGANAQLEDSMVELEQTGESGRGGTSSVISGLASPATSISDDSVQDASIPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R925</accession>
    <name>A0A8G1R925_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-deoxy-D-gluconate 3-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_446689</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518027.1">
        <property type="nucleotide sequence ID" value="XM_025659555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R925"/>
    <dbReference type="GeneID" id="37162957"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000398">
        <property type="entry name" value="Probable 2-deoxy-D-gluconate 3-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH60105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="265" mass="28223" checksum="7C0D72E7C06C28E1" modified="2022-01-19" version="1">MSAAVASLFSLSGKTAIVTGGTRGIGQAMAFALAEAGADIILIQRDESNTSTRDEIVNRIGRKAWIHVAELSNRESIKGVIPALTSQGLKPEILLNCAGIQRRHPSEKFPDEDWDEVIQVNLTSVFTLCREFGAYLLARDESEFPTGRRGAIINVASLLTFQGGITVPAYAASKGGVAQLTKALSNEWVAKGINVNAIAPGYIATDMNTALINDSNRNAGIMARIPAGRWGNPEDFKGVIVFLASQASSYVSGEIITVDGGWMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R966</accession>
    <name>A0A8G1R966_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T1</fullName>
            <ecNumber evidence="2">4.6.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_418153</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].</text>
            <dbReference type="EC" id="4.6.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.24" evidence="2"/>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516987.1">
        <property type="nucleotide sequence ID" value="XM_025657804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R966"/>
    <dbReference type="GeneID" id="37161206"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00606">
        <property type="entry name" value="fungal_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034899627" description="ribonuclease T1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH59065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="135" mass="14674" checksum="845F212F36EEABDC" modified="2022-01-19" version="1">MVQFKSIIALLPLFLSASLASPSARNNLESRESCEYTCGSTCYWSSDVSAAKAKGYSLYESGDTIDDYPHEYHDYEGFDFPVSGTYYEYPIMSDYDVYTGGSPGADRVIFNGDDELAGVITHTGASGDDFVACSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9T4</accession>
    <name>A0A8G1R9T4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_437428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517302.1">
        <property type="nucleotide sequence ID" value="XM_025658620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9T4"/>
    <dbReference type="GeneID" id="37162022"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="54703" checksum="92B04E2ECA578CD6" modified="2022-01-19" version="1">MSIDFHGHGRRLHIPRDIQYRWQVSIAYSFVAGCILRGVVLAATLIGIFALTFPLSETSLGGNYNLHYLSASLRRELRPSMGAYSPGISELEGRSFPVLSLVPRAPISLYLPRAGFLWSDELAWDIHSHKFNTKATPRSWRQTSTIDAVEEHIAHLNNNSSRVIFSDEFNTVGPWFFDQVLAGEYDPNDPVVAARIWPGQLVYLRQFETGEYVTASMDGVTLSDLYDNNLDDEVRRLHISADTQASALSEWQILYDTHQDKGVRLWNKVANCYLATSYRTYPNMHARDSNDTILETLHLQLEACCTYPPSRAASTFHVVDGVSKPLRPSTTWLPPFTGRLALYETRLRAHGAFTIDMISAMWNLFSFHRRHAHLQDMSVNLKELHIGVPYSENWSYVFQTFMICGVLLHLGHLLHVQRTHTPARKSHLSNESGPMPQVQLCYLVAHLAKTVVGSDDLWHCHFELGLAWVTIVDGVNLVVHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA35</accession>
    <name>A0A8G1RA35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_435001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520320.1">
        <property type="nucleotide sequence ID" value="XM_025658496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA35"/>
    <dbReference type="GeneID" id="37161898"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="301" mass="32991" checksum="DD1C626C5B403BB6" modified="2022-01-19" version="1">MYAFSTKRQRDQDQEDFDGNVFRETKKHRSLPLRASPSALQFSSLPQSNRLASGFGFSTLTPVESSDDDKEDNGADKFAHHGSTQPRDQPLPSEQGCIPIMSASMDIDNGKDAQCSTNNVEHSNPESVAGYTDYSLQPSPIPHGLVDQSLVISEEPTTHSTEGNTPAPRSPVVRDMVQNSTSYTSQGVPRGPYASHDRVWWCGQRLPSPVSDNGDAMAISSKGSVSDADMTYMSQPASPPPWYSETTPDVSQPAGSMGNLRREHHIPSSSKKKAAISMGYRADCDKCRRRVPGHYSHIIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA57</accession>
    <name>A0A8G1RA57_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_11508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520813.1">
        <property type="nucleotide sequence ID" value="XM_025653863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA57"/>
    <dbReference type="GeneID" id="37157265"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="278" mass="29937" checksum="DF85669CB4970FC5" modified="2022-01-19" version="1">MLERQTPTPTKTQFTFTCESDSSKGMALQAQNPYPAQHRSPSALTAAVQSQRGYSQGTQTIPNAASQANSSGASQQSQHSQPPQLQTAGTEPATTGRKKKRSPGSLYALAARQRKIQQQYANLHHPPSIEDIWICEFCEYESIFGHPPEALIRQYEIKDRKERKRLAEKKRLLEKAKMKGRKGKKATKNASKHAAAQHAAYDQGYDRASVDHSSTGGGPGVHDDEYLGNEYEDEGIPTPPPAPPGTLKNALPPGHPPKPAAAAGSGAKSAADGGTRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAH0</accession>
    <name>A0A8G1RAH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Autophagy-related E2-like conjugation enzyme ATG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_444979</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Monomer. Interacts with ATG8 through an intermediate thioester bond through the C-terminal Gly of ATG8. Also interacts with the 40 amino acid C-terminal region of the E1-like ATG7 enzyme. Also interacts with the ATG12-ATG5 conjugate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519468.1">
        <property type="nucleotide sequence ID" value="XM_025659155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAH0"/>
    <dbReference type="GeneID" id="37162557"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="101"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH61546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="359" mass="39404" checksum="BFDE5A607F213BEC" modified="2022-01-19" version="1">MNILHSTLSTWRDRLAPVSRTSTFRTTGQITPEEFVLAGDYLVYKFPSWSWADAATPAKRVSYLPPGKQFLVTRGVPCHRRLNDNFAGDAGHEDEIVRGMLAGEGDNDDDGWLRTGGGDNAASSSSSARIGDVRTVDEAGNMGEVEEPEEDEIPDMEDEDDDEEAIIREPVTGTTQPTRTYNLYITYANFYRTPRLYLSGYLSASEPLPPQLMMEDIVGDYKDKTVTLEDFPWFEGSVKMATVHPCRHASVMKTLLDRADAALKIRRDKLKAAASAHAEPDAKVAAGAGGLEGLVDDVKGLSVSEGHGGQGQAGGDEWEMLQHDEEDQVAIRVDQYLVVFLKFIASVTPGIEHDFTMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAI4</accession>
    <name>A0A8G1RAI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fructosyl amino acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_446038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518807.1">
        <property type="nucleotide sequence ID" value="XM_025659406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAI4"/>
    <dbReference type="GeneID" id="37162808"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH60885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="428" mass="47388" checksum="A82822BF2CA1F0D2" modified="2022-01-19" version="1">MDRNTRILIVGAGCFGTSTAYHLAQRGFTSIRVLDRYPAPSCEAASTDISKIIRSDYNEPLYARLGIEAIAAWKSSDLFRGLYHVPGWVLSAYKLSCAFVEGSIETCTKLGVEGLERLSTQQIRERFPLVTGELDGWNINVWNPTAGWAAAGEALRRMAVAAQEQGVEYISGEEGWVKRLLFNEEKHCTGVITTDGSTHVADLVVVAAGAWTPTLLDVAGQLTAKGHSVAHIQLSPAETAHYSALPIMDNLELGYFFPPQADGVFKMAHSQFITNMQTDTRSGNKSSVPHTFVDNPQDDLPLEIEAQMRRNLRRVLPELADRPFCYTRLCWDADTADRHFLISPHPNHQGLYVAAGGSAHGFKFLPVLGKYIADLLEGNLESDIARQWQWRAGQTVTAKNLAHQDPELELSDLTGWKGRKTRERGPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAK3</accession>
    <name>A0A8G1RAK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinate 5-dehydrogenase QutB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_483530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519419.1">
        <property type="nucleotide sequence ID" value="XM_025663164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAK3"/>
    <dbReference type="GeneID" id="37166566"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000030">
        <property type="entry name" value="Quinate 5-dehydrogenase QutB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF1">
        <property type="entry name" value="BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="1">
        <location>
            <begin position="25"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="345" mass="37228" checksum="7DCCD58CAAF43A2B" modified="2022-01-19" version="1">MASSNNTQPEEPITIPQDRDGVAYLYGHPLLNSLSPPLHAAIYNHLGLNWIQIPLSSVCGTSATYPPPYTRSPPIDTFLSSIRANPKFVGSSVTMPWKVSIMPHLDDLTEDARQAGACNTIFLRDNADGSRSYVGTNTDCIGIREALIQNTANAAERFAGKPALVVGGGGTARSAIYVMRKWLGASKIYIVNRDASEVQAIMEEDQQRNPSADKAPLIHVTDPEVAKTLESPAAIVSGIPNYPPKTEEEIRARNALTALLGAKEDGKPKGVILEMCYHPVIWTEIAELADAAGWKVIVGSEALLWQGLEQAKLWTGKDVVAVPGLLAMVKDVVAKNLAERQKATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB04</accession>
    <name>A0A8G1RB04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_516335</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519674.1">
        <property type="nucleotide sequence ID" value="XM_025664840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB04"/>
    <dbReference type="GeneID" id="37168242"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH61752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="333" mass="36759" checksum="AE91DAC909574AD6" modified="2022-01-19" version="1">MSFIPPVVHEWTQTALAHLPPPAQQALLHPLVPKALAAILAFTALRQTNRALNSLSLSNFSTRKWDNARELVLLTGGCSGIGKQVMTELSSQGAKVIILDISEPTFKLPPNVHFYKADITSSAALHPVAEQIRREHGHPTVLVNNAGVANDATILDEPEAKIRQTFEVNTISHFLTVKEFLPAMIERNHGHVVTVASQASFMSLGEIVDYSCSKASALAFHEGLGQELKYWHKTTGVKTSVVHPLWVRTPMIQQLTDAGKEFKQPVLTVERVGSTIAKQILSGKSGQLVLPESLWWISLVRAWPTWLQETARGLASKDLVKLRSWQKENDVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB05</accession>
    <name>A0A8G1RB05_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras guanine-nucleotide exchange protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_119206</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519783.1">
        <property type="nucleotide sequence ID" value="XM_025653898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB05"/>
    <dbReference type="GeneID" id="37157300"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF354">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="60"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="695"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="875"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="497"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="621"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH61861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1160" mass="129498" checksum="B23F337FE084E7FA" modified="2022-01-19" version="1">MESMKRHIAPLKIEKGNLNYNYDDQQHHYHYQHNLEMSPPLTPYENKDDSMEQSETPRAVFHNYLRAFYPYHPSGNVSPSTVTLPLDQGDIVLVHSVHTNGWADGTLLDTGARGWLPTNYCEAYDQQPMRPLLKALTDFWDIIRGGCGFPLNDAGNQDLVRGLIAGVRYLLQKSECLTRDCILVTSHDGLRRNRKALLAELSSLVRTTKRFQEVASGNATQDEMDYMVDEMLLKAFRIVTRGVRFLDVWTEEVGLSRTIAELEQQSGYQQGPLTTVSETRPISEAAGSEADTERNESRLMNRSRLDMSRASTRLDDSQQTRPVSVTTKRISVSHRVSTSGPAAIARNPNLASERLNDAYDAFLGVLGSFIGLHLQSRSSTELVVTTEQAVRSCRALLTVVEATCEHDPQGSGLLEQARDTMYERLSELVYAARDAFRPAHSPDDELVFLPDEGKRLVDAATDCVRAAGSCLAKARLMLEQCGDFELEAMPQDLPAATGAMTDANKTPQPPKTSTFAGHQNRSQEASLRLPPPPLQIPNSINNRYSPPTPGLTDDTTPSSFQSRNGASTPGTDMSSFPSTSHLSTSLDKLSFSSHDTQPIEIPPHRDSQAKSDVSESFGRGITSNGSSFTFNSRLRDSEMSGVSQTSTRATSPDIGNHYQVPSLKGSISHSTLAEETEEGEANILEKTYAHELIFKDGQIMGGSLRALVEKLTAHQSTPDAMFVSTFYLTFRLFATPIEFAETLVDRFNYIGDTPHTAGPVRLRVYNVFKGWLESHWRHDCDNCALEYIVNFASTTLMHNLPSAGKRLVELAEKVSMVHGPVVPRLVSSMGKTNTATAQYVHPDTPLPPPILGKKEVNLLKQWKNGEGTITILDFDPMELARQFTIKESRIFCAILPEELLATEWMKKSGSLAVNVRAMATLSTDLTHLVADSILQLEEPKKRAAIIKHWVKIANKCLELSNYDSLMAIICSLNSSMISRLKRTWEVVSQKTKTTLEYLRGIVDVSRNYYVLRQRLQNRVPPCLPFVGTYLTDLTFVDHGNQALRTLPTDEGDMAVINFDKHMKTAKIISELQRFQIPYRLTEVPELQAWMQNELVRVRSSGEKSLQTFYRRSLVLEPREVPQARMQPESSSSSILENAKDKFDFLSWTHPSKSKSVATNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB56</accession>
    <name>A0A8G1RB56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">BO85DRAFT_363318</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519873.1">
        <property type="nucleotide sequence ID" value="XM_025655655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB56"/>
    <dbReference type="GeneID" id="37159057"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000037">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000447">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="25">
        <location>
            <begin position="385"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="RAH61951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="749" mass="84494" checksum="0F4D3D6A6A67DDBA" modified="2022-01-19" version="1">MADGTYRFQQPGAGQFFFQTQTQQHSHQRHLVRNGTNSPTGRLKFSHDTPSPSRSPPINQAAALNPFTMYTQTHQGQHVMMNGGQAHQRFGMQIPKFQSQSHHPHPAQQAHHHAHHNQASHSINHQHNFSSGALAAATPHFTPGPLQNGAHVNVDEDIDETMNEHWQQQLQLAAESRQASSPHYYARTVAQQTKGIQIAPSHPEQQENGSGDRNGLVKSKPAPRQGWHALDFGGQGLRALATSLFHYTFLEKLYLNHNKLKTLPPAIGQLRKLTHLDLSSNDISELPEEIGMLTSLKQLLLFDNNIRTLPFEMGYLYRLEMLGIEGNPLNDILKSQIIKEGTKALVRYLREEMPVHLPPPDRDWIILDETASSSNTSIEKITVLSHNALCDSSATPSHFGYTPSRVLSWEFRRELILSELRSHDSDIICLQEIDQGSYNGFFREQLAYNDYKGVYWPRGRAMGMQEEEAKSVDGCATFFKGSKFILLDKQMINFGQTAVRRPDAKGQDDIYNRLWQKDHIAVVIFLENRLTGSRFIVVNAHLYWDPAFKDVKLIQTAILMEEITKLSEKYAKFPPCTDKTAFRFSEAEGESDTPPPEPAPSVEYSSGDQIPLFMCGDFNSAPGSAAYNLVAHGRLTESHPDLEKRLYGNLSRVGMTHPFKLKSAYNSIGELSFTNYTPDFKDILDYIWYTSNTLHVSALLGEVDKEYLQKVPGFPNFHFPSDHVALFAEFTVKGKKGKVVEADFGPQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBA6</accession>
    <name>A0A8G1RBA6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_363737</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519824.1">
        <property type="nucleotide sequence ID" value="XM_025655670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBA6"/>
    <dbReference type="GeneID" id="37159072"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH61902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="157" mass="18129" checksum="14B8377C1FA576E9" modified="2022-01-19" version="1">MSLCQNRLTEERKQWRRDHPFGFYAKPHRTPQGTLDLKRWECGIPGKAQTLWEGGLFKLDVTFPDEYPTKPPKCKFVPPLFHPNVYPSGTVCLSILNEEEAWKPAITIKQILLGIQDLLDDPNPESPAQAEAYNLFKKDRPAYEKRVKQVVRENPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBR1</accession>
    <name>A0A8G1RBR1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="11">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="11">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="11">PHB:PPT</shortName>
            <shortName evidence="11">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_516375</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Mitochondrion inner membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
            <orientation evidence="2 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="11"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519721.1">
        <property type="nucleotide sequence ID" value="XM_025664842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBR1"/>
    <dbReference type="GeneID" id="37168244"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH61799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="415" mass="45312" checksum="B86AE84AC7E54F55" modified="2022-01-19" version="1">MSYLYAGRHARLCRYPRERSTYIYRFTSVQGHRCPVSLSSSRRYGYTATNSIQSICQKSNITTHNRHPRRSALILSQAHSTTSQASVTSYTPPNKGLISYLPQSWIPYAELLRLDKPTGTYYLFFPCAYSTLLAASIAPSVSAWDVIGTTGLFFAGALIMRGAGCAINDLWDRNLDPHVERTKFRPIARGAIPPGKAVLFTGTQLLAGLGVLLQFPYQCLWYGIPSLLLVTTYPLAKRVTYYPQAVLGLTFSWGAIMGFPALGIDLLHNAAALETAAALYASCVTWTVLYDMIYAHMDIKDDVAAGIKSIALRHEKNTKAVLSALAAVQVPLLAAAGVAAGSGPIFFIGSCGSAAVTLGLMIWKVQLKNVQNCWWWFKNGCLLTGGGITLGMFLDYVAKTTGFYDPDEEPVSLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC46</accession>
    <name>A0A8G1RC46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS9m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S9, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_361553</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521396.1">
        <property type="nucleotide sequence ID" value="XM_025655593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC46"/>
    <dbReference type="GeneID" id="37158995"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000001">
        <property type="entry name" value="30S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_uS9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001099">
        <property type="entry name" value="PRK00132.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH63474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="317" mass="35013" checksum="F07A3268ED4352FC" modified="2022-01-19" version="1">MAWQSPNGLVHAMHSIRRAAQLRPFIQRSVISASSPVSSPSTPALLQQCKNARSYATEIEPVAAPPIDLDSFITRPARIIPVSPAYFSGSPKFFDHMLKLEALLAKYAALPTVSPSEAPRMAWFKLLQFRDAVGEPVPTKKYKGLIKLLQRLNRIDPNVAPEEVRTALNFFLRPGNPYGNKPAPRTVDEQGKARGKGKRKASSAVVHLVEGEGEVLVNGKTLNEVFPRLHDRESAVWPLRCTSRLDKYNVWATVRGGGVTGQAEAITLAVARALLVHEPALKPILRKAGVVTVDARRVERKKPGHVKARKMPTWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCP8</accession>
    <name>A0A8G1RCP8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Outer spore wall protein RRT8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_515373</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520683.1">
        <property type="nucleotide sequence ID" value="XM_025664782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCP8"/>
    <dbReference type="GeneID" id="37168184"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH62761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29164" checksum="5DB08DEF85B2DE2D" modified="2022-01-19" version="1">MNKVTGALIDEATHIRAIAKDVVLSGTYFYPIKGIIYTLNRPTLRQPLLSRSSKTLTLGVGVTTAMFFFTYVPQAAIMSITSGPLLAPFSAALLVLSESSTITTFLARSFLLADAITATFDATLVEMGQEKLLEQSGKRGGGDEVMSRFGGKEEVEERQTNMWNMLVRSVVLLPLNFVPVVGTIIYVYVQGKKVGEGVHERWFGLKGWKKAERSRWVGRWRGKYTGFGMAAFALEMVPFVSIAFAFTNTVGAALWAADWERELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDS5</accession>
    <name>A0A8G1RDS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MATE efflux family protein subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_414934</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519342.1">
        <property type="nucleotide sequence ID" value="XM_025657666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDS5"/>
    <dbReference type="GeneID" id="37161068"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="625" mass="68398" checksum="2F96ADE55D2B52AD" modified="2022-01-19" version="1">MARRNSIRGITDEQFHSRYRSSSPLARTAIARDIEDYADDEGSMLTTDDEASETSTIRAINSQPGTNPHSLAGSYQRPGFFTTVSHATVVPHRPDSEGLTRRERERAIEDERNLLTDNRCIEPGVQKGGRMRRGEAAESTETAALLGGQRRGSQYETVEDQDEIDRKWEEAVTAGLIQTTWKREAQVIGKNAAPLVVTFLLQYSLTVASIFTLGHLGKKELGAVSLASMSASITGYAVYQGLATSLDTLCAQAYGSGRKKLVGLQMQKMVFFLWAISIPIIVLWFFADRILIRIVPEKEVAMLAGLYLKVVALGAPGYACFESGKRFVQAQGLFSASLYVLLICAPLNAVMNYVFVWQFGWGFIGAPIAVAITDNLMPLFLFLYVYFIDGSECWNGVTTRALRNWGPMIKLALPGLLMVEAECLAFEVLTLASSYLGTTPLAAQSVLSTISSITFQIPFPVSISGSTRVANLIGATLVDAAKLSAKVSMVGAVIVGLLNMLLLSSLRYYIPYLFTSDEEVIELVAQVLPLCAAFQLFDALAANCNGILRGIGRQEIGGYVQLFCYYAIAMPISFGTTFGLNWGLFGLWSGVALALLLVSIIEAFFLTQTNWHRSVEDALRRNAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RE27</accession>
    <name>A0A8G1RE27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_109983</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519507.1">
        <property type="nucleotide sequence ID" value="XM_025653843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RE27"/>
    <dbReference type="GeneID" id="37157245"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="8"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH61585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="345" mass="37252" checksum="CD9DBEE84F4B45C0" modified="2022-01-19" version="1">MVKAIAVTAPETISVVSDWPKPTLRHDCILVKVVSVALNPTDWKFALRSTPIVTVGCDYAGIVVDVGPAVTKPFRAGDRVFGVIRGCNPNLPYNGAFSEYILAPGDLQCAIPENLSFQEAATLGVGMGTIAQSLYQSLQLAPFDHPLAQPEPILVYGGATATGTLAIQFAKLSGYEVITTCSPETEELVKSRGADHVFDYKDPEAADKIRDVTQDRLKLVLDTISTDETAAFCGRAMSSQGGDYTAMIDSKVPRADVRSRWTLGYTVFGEELTFRDVRIPAKLEDRTFASEWMEKAAKLLADGRVVPHPVQLGSGGLQGVIEGLKLLKEGKVRGCKLVYNVDETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1REC2</accession>
    <name>A0A8G1REC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_360058</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521444.1">
        <property type="nucleotide sequence ID" value="XM_025655537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1REC2"/>
    <dbReference type="GeneID" id="37158939"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="15"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH63522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="338" mass="36493" checksum="C04E7D1AA7F919EF" modified="2022-01-19" version="1">MSPLNEAAWILKPKSDLKRFTAAYNIPSLDEIVIENHAVAIQPLDANIRAQAYVDVPYPFILGNGVAGIVHEVGSSVTKFKKGDRVVSDTPTYQLKEAKYGGWQKYVVTREATTAKIPASTTFDDAAAIPFALLTAVSALHLHLGMGKPGTNSKGKALIWSGSGSVGGYAVQYAASVGCEVIATASPRKFDYVRGLGASTVLDYKDDEIVSKLKSLGPFDYIFTASGDAKSANAISDILQPNGGRFASVRAQSKEINLAQNVDLIYDFFSMTTQKEEYGDFTEWWYREYLPGALGGNVTPTPLEKRAGGLNSIQEACTDVLEGRSPKKLVLNPQDPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RGN7</accession>
    <name>A0A8G1RGN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_410380</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520872.1">
        <property type="nucleotide sequence ID" value="XM_025657478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RGN7"/>
    <dbReference type="GeneID" id="37160880"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000643">
        <property type="entry name" value="Short chain dehydrogenase/reductase family oxidoreductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="564"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="672"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="696"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="782"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="12">
        <location>
            <begin position="339"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="642"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="735"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH62950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="808" mass="87622" checksum="4515768F39427537" modified="2022-01-19" version="1">MSFAVQGRAAIVTGAGSGINLSFAKLLLEHGCNVLFADLALRPEAKTLVDQYSAKGKTPRAVFQRTDVTDWQQLEHMFEVAEQEFGELDIVCPGAGIFEPHWTNFWRPPGTPESRDPRYGGRYALLDINLTHPIRTTQLAIAHFLRHGNKQRRKHIVHISSIAGQNPNFIAPIYVATKHGINGLVRSLAGLDQECGIRITAVAPGVIKTPLWTDHPEKLKVVNEGADAWVTPEEVAQVMLALIQQDKVSGIIGDQSGRGPQYPVSGGTILEVSKTVRAVEPFNDAGPGDRPGNTVSDNSAVINETLAPVPLPVPLPILVPIGRRHGGKGKRSIGHHGDASWVSCVINLVNTIIGAGVMAMPLAISHMGIVLGVFVILWSGMTAGFGLYLQSLCARYLERGTASFFALSQITYPNIAVIFDAAIAVKCFGVGISYLIIIGDLMPGVVQGFVGGAPDYDFLVDRHFWVTAFMLIVIPLSYLRRLDSLKYTSIAALVSMAYLVVLVVYHFVKGDTMEDRGPVRVIHWAGPVPTLSSLPVIVFAFTCHQNMFSILNEIGNNSHFRTTGVVLASIGSSAATYILVAITGYLSFGNSVGGNIVSMYPPGLWATIGRAAIVMLVMFSYPLQCHPCRASVDAVLRWRPKSSSNSDTAPHRNPLLGQRGGRTAEPMSDLRFSIITTTILVLSYIVAMTVSSLEAVLAYVGSTGSTSISFILPGLFYYKISSPDSPHHQRLMKEDDEAAEGMLSDDSNDEDGEESVQARPLTDSGILRRGKRHWRRTLLRKLSLALVVYGVVVMVVCLITNSVFIASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RGW0</accession>
    <name>A0A8G1RGW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_494704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521007.1">
        <property type="nucleotide sequence ID" value="XM_025663872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RGW0"/>
    <dbReference type="GeneID" id="37167274"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="529" mass="60514" checksum="24779E199048B6FB" modified="2022-01-19" version="1">MASARTGSGTLSAKSSIESCIRELYRHHIAYLEGYPEQAQDEDKGMVSPNETNNEISAMEATSANIPDNRSESIGEPGPSVNEEPIEPTPTFITQNNPNSGLPLPLHVNTERFPEYYRSCENRDARQNRQIGESYKIAISKICDEVISFRQIDSLATAPLPFTMAGDEDTINASTMNNVSETPKIESPPTPASQLNTPRAGVGSDSIPLVAEERKKSTIEQMRNMTSSEHMSLTTKTRFIDMGNTVLRLELLFFRRHATPMDPVLGLTKDEVKEVMHRLEELKKCISIVDHILQQELTWARRVEYSVKQIAEDTQYNVVTRFRNMTELILNHLNKARPSERDLLTVFLDFFDAHIYTDFMNDYQRQLPVKENWNPVRVEMTRALIAVWDLINRAIESYDAIIRVTVDIKERYTEPHYREMQETPQAWRSAMLAHHIEGERERQRQVAQRAEARKMAYEQAKEEKRRDEEKKKEEEARTVAGVKDYVPFTAEMDPTVKVRDFAYEALAKAGQSAVSGSKDDEDSDDGWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RH98</accession>
    <name>A0A8G1RH98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenases/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_411129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521217.1">
        <property type="nucleotide sequence ID" value="XM_025657513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RH98"/>
    <dbReference type="GeneID" id="37160915"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF148">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH63295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="288" mass="31487" checksum="43A29DC9FF467A3A" modified="2022-01-19" version="1">MAKTIVATGISSGLGFETIKQLLEQAEPYNFILGARDTVKVQAAYDSLNYDTSKHSITIYPLDLLSLKSVQSFAANVRSKLGSEKLAYLFLCAGTLDNGEGPGPNGSQWCSGYVVNHLAPHYLVHLLRDVLSASQSRVVFVSSGAIRGLRDQDPATLDVDLKANSGAGYRPIYSASKFVQLLGAFYWRRELPSCTVVAVSPGLIPSTPLASSMGLTMDMPDAKTIPEGAQNLLRAFFINDFPADPEQIFLTSWGEWWPKDVYALALDADLQKKWCLSREEIEKTESIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGM5</accession>
    <name>A0A8G1VGM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF821 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_454545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825093">
        <property type="protein sequence ID" value="RAH51770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509692.1">
        <property type="nucleotide sequence ID" value="XM_025661312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGM5"/>
    <dbReference type="GeneID" id="37164714"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF112">
        <property type="entry name" value="DUF821 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G14740)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="167"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH51770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="442" mass="50365" checksum="A53C531B0099F94F" modified="2022-01-19" version="1">MQLLQNQLTSFRFIATGAVLSLILTTFLIFGAQYSNDVAKYALKTSLKPTPQTCLQTSLPEAGNATAWEFMVERDGDNHGLSDEQCRLAFPKLFVELDKSASLREGHRITFKEVDSLQVEDGMVRGIIHHGELYVVDFGAMPATFTRGKSTLHALHRALASFPDRGSLPDIEFVLTTEDYSIQEGPVWSYSKRDEQVNVWLMPDFGYWSWPEVKIGPYKDIRRRIAAVDDGEVTLDGKFIPGLPFPDKKKQLAWRGSVATNPEVRGKLLKAAQGRSWASIRVIDWDDENDVRFNLLPMEDYCQYMFLAHAEGRSFSGRGKYLLNCRSVVVSHKLVWREAHHAALIASGPEANYVEVERDFSDLDQKMEFLIDHPETAQRIAENSVKTFRDRYLTPAAESCYWRQLVRQYAASCEFEPVLYTQENGRRDPRGVPFESWVLTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VH04</accession>
    <name>A0A8G1VH04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_241209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825095">
        <property type="protein sequence ID" value="RAH51727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509649.1">
        <property type="nucleotide sequence ID" value="XM_025654848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VH04"/>
    <dbReference type="GeneID" id="37158250"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000046">
        <property type="entry name" value="Amino-acid permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF14">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH51727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="499" mass="53813" checksum="56ABF6EE2F627328" modified="2022-01-19" version="1">MEKSKVAHDGPEDDVQLAEMGHKPELQRNFSTLSMLGLAFAVLNSWTALSASLSLSLPSGGSTSVVWGLVTAGFCNLCIAVSLAEFLSAYPTAGGQYHWVAVISWPKWVPILSWVTGWINVAGWVALVATNALLSCELIAGIVSSVYPDFVWQRWQEFLIYVGYTLLAFVINAFMNSILPIIYRGAFTWSIGGFVLICITVLACASPDYNSAYFVFCDFVNQTGWPDGVAWLLGLLQGGLGVTAFDAVAHMIEEIPNPSIKGPKIMVVCVGIGTFTGAVFLIVLLFVAGNMDEVVNSSAGPLLEILIHATNNRVGGICLLMLPLVCLLFATLSVMTTSSRMIFAFARDGGLPASKFFARVHPRLGLPLNALILTAFVVIIFGCIYLGSSSAFNAIVSASVVALDLSYAMPIAVNCLRGRRTLPDRKWKVPNAIGWVIDTISLSYIALTTVLFLFPPDRPVTGSSMNYCIVAFAIIVIISVVQWVVDGRKNFTGPRVDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VH66</accession>
    <name>A0A8G1VH66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_482280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025663094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VH66"/>
    <dbReference type="GeneID" id="37166496"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH51922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="298" mass="31364" checksum="5E05985B6A04F1CF" modified="2022-01-19" version="1">MELLLTQDIMSVKGRIALVTGGSSGIGRMISQGLVTNGAKVYIVALPGDPIDQTVQDLNACGTESGGSAEGYACDLSSKESISQLAKSISEKETKLDMLISNAGIRRDPPIACNVLTATLAELQESMWSSRESDWADTFQVNTTAHYFLSVAFLPLLAAAADQQLDDGRRGQDDGRGVVVITSSCASMHNATNVDLTSYAASKAATDHLVKLLAAKFHRFYVRVVGINPGFVPSNMNPVGAAGNMFSGLFDKVPAKRAGRAEDLAGAVLYLVSRAGSYVDGVSLCIDGGRILLANGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHP5</accession>
    <name>A0A8G1VHP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_381102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511551.1">
        <property type="nucleotide sequence ID" value="XM_025656404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHP5"/>
    <dbReference type="GeneID" id="37159806"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034137099" evidence="1">
        <location>
            <begin position="22"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="54"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="528" mass="57074" checksum="DBD25782A1F1406E" modified="2022-01-19" version="1">MLPKLATLVLAPALANGVAVAAEPLYKKPVNIPGYGYVQGKAAVNSSVSEYISNWENISFFGGIPFGADTSGANRWRDPQPVEAWNGTLNATEFGAICPITLSILADYAQSEDCLNLNIWTPATSPDEKLPVAIWSYGAGTAPPQTTYNGAGVADKGIIFVSYNYRNGVFGFMAHPELTETNGRNASGNWGVLDQYAAVKWVHENIAAFGGDPDHISVIGQSFGAAAAYHIVNSELTADLGIVNAISESGVRSPNDPNTGVYECAYTTLDDAETMGEEIISSLNVSSIAEARAIDTTTLLDSTSTYSLEVKPVLDYYAIPSKYINTLENGAGNKVPYITGNNANEDGASATVSTTVAAYKSSLNSSYGDFAPRFWALYPADNDTQAGEQEDQIVRDMFRVSSWQYMNGFSNSADQVDTYTYYWNYGSAAHASEIIYVLNNLWAQGEDYSEEDYYVANVMSSYWANFMKTGNPNTGGSYNNGTLPAKWNANSPSKNETFLVGAVYETMDTAATERVQLILDYFAAQTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHS2</accession>
    <name>A0A8G1VHS2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase activator Bem1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_442762</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
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</entry>
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                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
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                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J."/>
                <person name="Theobald S."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
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                <person name="Kuo A."/>
                <person name="Riley R."/>
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                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF14">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034921832" evidence="5">
        <location>
            <begin position="20"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH55894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="364" mass="39410" checksum="861B449E45CC69F4" modified="2022-01-19" version="1">MKRLLCLFIVLLLSYVVRALPYDDHGKKRDLGPLGDLPGGDVIVWVDQAGNALANNVVGGGGNSNPTATAENSPATLPPLLPTLDDDLDLSPAVPLPESTKHPKTGNYRRFGISYSPYNGDGSCKTQDQVNQDLDKLAQYGFVRIYGVDCDQTNKVAKAARQRNLKVFAGVFDLQNFPSSLDYITGAANGDWSVFHTINIGNELVNDGKNSITDVTNAVNTARNKLRAAGYQGPVVTVDTFSVLIQHPELCQASDYCAANCHAFFDNNNTADKAGQYVKDQANKVSKAARGKKTLISESGWPHNGQPNGKAVPSSQNQQKAIASLQQTFTGDNELVLFTAFDDLWKQDSPGTFGAEKFWGINQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJV6</accession>
    <name>A0A8G1VJV6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_406751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511045.1">
        <property type="nucleotide sequence ID" value="XM_025657345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJV6"/>
    <dbReference type="GeneID" id="37160747"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF4">
        <property type="entry name" value="HYPOTHETICAL AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH53123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="580" mass="64070" checksum="E07911E7B4FC8B14" modified="2022-01-19" version="1">MSLVQHVSVIEGVDREPEHQDDSTIATAVTGEPFAPIHRKISYDVLQPPPAPVEVAGTPAYKVSTAKRLAQVIVTILACWFAAGVVFGFAALKPVLVAEGVYRDLCTEDELRDGVEVCSEQDLRLNLFFTIGSITANVSALPVGTILDRYGSRICGFAGCLLLALGSSLMAYSFSQPQFDGYMVGNFFLALGGTFIFVPSFQIANAFPKYAGTIVALVTGAFDASAAVYLFYRLVYEMTNGSFDPGKFFLSYTAVPGLILVALITLMPSHDYQGTHELEVKIEKAEDATRDIHDSDDDIESDTELRRVRSERAERRQNKMRKIAKVLGDKGERKEREQREEDRHAASAVWGALHGQPAHKQMATPWFILITLMTVLQMLRMNYFIATIRAQYAYMLDSDELAVQINSFFDVALPVGGIISTPFVGLLLDHISVPAVLAIIVVLTTVIGILNSVPVLWTGYVTVTLFVLLRPLYYSAMSDYATKVFGFATFGRVYGTIICVSGMVNFAQYGLDALTHGPFDGNPIPINIFFAIAGFVIGTALVSFVYVAGRRLRAREQELEEDEERQRLIREESDEEDYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK18</accession>
    <name>A0A8G1VK18_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vegetative cell wall protein gp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_375547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514176.1">
        <property type="nucleotide sequence ID" value="XM_025656175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK18"/>
    <dbReference type="GeneID" id="37159577"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="391" mass="44200" checksum="CA4D18622D00BCA1" modified="2022-01-19" version="1">MYHYPSPHPGWSSYDYMTSPPTSPHYAYYATQFASPYASPRGPSKRHNRKASYAGPRETAGWYSGYGHGIYEAMPEHGTPPRKHDPVSASFGGYHRRRSTMAGAPAGQWDSAGAPPSHKRPIFVDVVDDGYDDAPRYVFREEPSPPRRKPTTPPRKPKPPTDQYFYYNQVPAQDDVDSAKRARARRQSTSTRTPSKPKPAPAAKPPPKATEEDAARAGIPEGYSIKNWDPTEMPIILLGSVFDANSLGKWIYDWTVFHHGASTPMADVAGDLWLLLIKLAGKVKRADECIERIKRRDARETVADFLESGERLWVRFKKLLKTCEQFMWKAAKREGGKTVSMGRNAGCEFVETIFGRDRELESTEKLMNSIRLWNMRFDANCEEILRRPTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK55</accession>
    <name>A0A8G1VK55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_492216</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511315.1">
        <property type="nucleotide sequence ID" value="XM_025663766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK55"/>
    <dbReference type="GeneID" id="37167168"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="68"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH53393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="737" mass="82268" checksum="F5E3E444512C1EF1" modified="2022-01-19" version="1">MESRPAMKRASESEIDPPRTRPCPACNKTFSKAEHLTRHLRSHTKERPYVCTTCGKVYSRSDVLRRHLKSHEKHSQKASPQPRASISGTPSRSVAEESTIISSPSHTAPRIHELLNDASLIVPAVHDQLISSTEPSQSQSAAGMNLHDSVLQTDTDSWFLGADFDVNALDFSISSAISEWAQLPSTPHMLGSVGLAGEPLPSAPTSYAKGNIDESHSADIVRKRWFTCLSPPEVNQFVYRGPNRPGDSFPQGRIDADDNYRAGLSQRLKPRMHDEALPSAEQLNLFAKLFFSRFHSLFPVIHAPTFRPTAENSLLFLSICSIGSLFVGSSHAVAQGLRIFERLNKAILASWESILAHSRPDALSMVQAAILGQTYGILSGRPKDLVLADVLHGTVMGWTRESNKYATIGHGQFLDSCSTEQELIEQWHRWAEAEQRRRVEIALNIHDAELASLMHHEPIRKHRFTQYPLLASESMFMAPTAARWADIYKQSPSITKLSPTPDLHFHSAGHDSRFAVYSVLESINAHVIEARLSGTLDRDTCRNLSSLLMHWWSKYSLQYIRDEEEDPFSLPVLWHSIYMSLYSDMDLLERAVGRNGHAAATESHHAVQAWAGSLDASKCLVHALLIQRYLERMRISSEPAIHVPGALFSAALAWLCFTRIGQQQSINLKAFDAPEIQLLGSETALQEAQGQAFGDSAFADVNHLHRLIDLLHRFGRWTISKTFATVLCTALEEVREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKE4</accession>
    <name>A0A8G1VKE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_441962</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511555.1">
        <property type="nucleotide sequence ID" value="XM_025658820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKE4"/>
    <dbReference type="GeneID" id="37162222"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15537">
        <property type="entry name" value="PHD_BS69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="6">
        <location>
            <begin position="93"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="144"/>
            <end position="249"/>
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    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="263"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH53633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="373" mass="41624" checksum="49778302F5445085" modified="2022-01-19" version="1">MAVRKTRTGRLARAAQDERHSVRSSLVKSSRTNPTRTGRQGVTLQSLNQSDEPLLPRLMSWSDTLAAVGEQSLETQVQRYKEWKRNGSAHEDYCRVCQAHGGRLEPCSTCRLAFHADCISAGWLRDSQDSLFCPICVRRGWHITPPTLSPPASPPPEERNDPTSAAAPTTSAPHPDTNSSSNTHPHSSASDGPLGVCSIQQAPTGDRHDVSASCPTTPKRLYELLGNDDEATEGNGTSQRPRRQRKSRYTNLPTEVDTALSVLYRELESNESLRREVEELRSENTKCNQTIRIRDLSIIALRRELDYRRSSAQEIETLRATATQLENAKKEIQELRARNEALSAELQTSRHETAEAQALVRDWKAKLSQLIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKH8</accession>
    <name>A0A8G1VKH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Inner centromere protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_64832</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513622.1">
        <property type="nucleotide sequence ID" value="XM_025665557.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37168959"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="9">
        <location>
            <begin position="1213"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="70"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="443"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="704"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="376"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="462"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="600"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="635"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="721"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="745"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="806"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="842"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="852"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="886"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="897"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="926"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="947"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1026"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1127"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1180"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1216"/>
            <end position="1225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH55700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1316" mass="145643" checksum="6CD05F7E78C2DC57" modified="2022-01-19" version="1">MAAAGARAQKPVGSAAWISTEKENFMQLVDQEMEEIEYPVRHEMDWLNEHMAEVFSNNQSNFADVFKTPGKLRGKTPRTVRKRDANESRVPLSEIFSSANNNSKTENKFSASPAVQRSPTKPVTAAAGPATATEAKKTTEKTSQPEYPDLTQNLNSFPQYNTDSGYHGMPEDERDEEEEEDDVVLTQVQPESQSSTQPMDQEPSAAEEQLHQPHEERRATGASFHSAREDVHQREETVEPEVTEPSPKRNVSTSPQKQKSPTKNTEDVDEAPPQPEEEPEDKIMSDVDSEQEPASESARKGIVELEPEHAPEPEAKPSAQAHQEPGPEEEPEATPRRESPPTEKAAPKPVSSPLKDTKSSPPTNATSQPREHHQDDPDDANDDMALDSLDEIGSPSEGSPVRPPIRKSSLTFASLPAREPLTKKSLGGSRISRTSHLDLNKLSSAGGYLGRQTGGHRTTQHVAEDSNIHDDRMDIDDKKDVTEETRDAETRASKLHNKSSTQLLHEKISMLGKLQPSRPTKSIPSVPGLSTAQVTYPELPTAKSEAKQEPSGSKPRETPAPDSAADDDWIKPLNSPYRPDVRASQKAGSLGKYSVARIPRGGEEDRPSVDRERDVHPTEEPRTSSKHASDAARGKSSTPSYSSPQRPAHQKSASANLDNQMSTTPVGSPAERYDGPISASKSRLQSIVQSAKGLFMNTGGVTAAARVESASPDQPRLRHTGRLDTDRNRESQRPQSTQPPSPPRQEGRRTRSSTEREEKRRQKELEDRQKEEEQAERARQLEKQRTMKLKAPQEKPTADPEARAPTTESATVLPTQKTSHLQKPSKEPEPSIEAGPKLVAPSSVSQQQSSKQNERRPLKPAREVQKPKPQPVSIRVGSALSRQMPLASQVSSNTRESSVPAPTPASASKPSTLKKKASNTSLHTASSNSSFKSSISSQSQRKAQLASERKREQEEREARRREEQRRELERKRAAQQQEEARRQEMRSRAEAERRERLAAEDPKKAAHMQAIEKRRLENQRRLERQGSQQPEASQRSELGAARPASRLGSIQPFNRSINQPQPNPAKPPKRGLDDEANHRPTAPKSATMQPSGETKRRRTEDEQSRMSSMRPAMAPPIRQSNIRKEPTQPSIFGHTQPSVAHQSGSSIFKTGQAQRPGHPLDMAKYASGKIPFAEPPSVQPAAHRTPAAASASQKAPVKESPKYPNGENINLPEIATDSEDEDSDAEMLPVPKWAQPKELESLLRQQEGMEVDSIFGPIAPFSLEETFKSDKKIKKFRERTSSANWSGADGLTQDEIRRDLAERQRLRLNGGWSFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKL9</accession>
    <name>A0A8G1VKL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_399370</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Commits homoserine to the threonine biosynthesis pathway by catalyzing its O-phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514836.1">
        <property type="nucleotide sequence ID" value="XM_025657092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKL9"/>
    <dbReference type="GeneID" id="37160494"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000068">
        <property type="entry name" value="Homoserine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="71"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="17">
        <location>
            <begin position="269"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH56914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="354" mass="38281" checksum="821DAF14A17DD9AF" modified="2022-01-19" version="1">MAATSFVIRTPCSSANIGPGFDVIGLALSMHLELHVTIDTSKSSQEPLNCRITYDDLSKSTEKISLDPEVNLITRVALYVLRCHSQRAFPAETHVHIVNPIPLSRGLGSSGTAVVAGVMLGNEVGKLGLSKDRLLDYCLMIERHPDNVAASLFGGFVGTYLNELAPEDVARKEIPLSEVLPSPAGGIDTGKRPPEPPIGIGHYRKFQWAKEIKAIAIIPDFVVPTANARNVLPTSYTRADVVFNLQRAALLPAALGSSPPDPDMIYLAMQDKVHQPYRQTLIPGLTEILQSMNPRTQPGLLGICLSGAGPTILALATDRFEEIADRIISRFATNGIACQWKLLEPAQDGTTVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKT9</accession>
    <name>A0A8G1VKT9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_439391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514808.1">
        <property type="nucleotide sequence ID" value="XM_025658712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKT9"/>
    <dbReference type="GeneID" id="37162114"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="454" mass="48805" checksum="6C8E33FC8DF1E01E" modified="2022-01-19" version="1">MSLSMPRASPARILGGTTLLSTFITTILDGMCFTFSRSLSSRVSSVESAIVSLGAVSCLALVSLMLLWIKDIKTEPTEQCRNHRAIAYGLIAAYLSVATGVTAGGIAWSAAQSVSAKKSVTRHQSLLVARCTIWAISVLSQGILGGYFLTTLARRESTSKWSPPSVSQELEVLSDKASVKDASTVQSSSLASESQRPSADLKTNSDTVPPIQPSVSNTESQASNRYSGRTLFQHDSKQSSFDLQRSYVPHGDSTATPATVEEHPVDQAGSAAAGIKLRPEPPKIRRSYSDTKRSLDGLVRQPSSARSSPATSSTQLVTPARPAPPKLKLPDESFIHPLFRSDSSSPPPTPMPGTTVIASPAAGQTISVQALNRVRSTRSLRSQAPRSRSPLFDQPLNGMERNTESPEPSGRGSPMPSFIMAADVRSSISRSYNASWLSTEWRVCRQPKRIMIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL15</accession>
    <name>A0A8G1VL15_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein Ral2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_438979</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515048.1">
        <property type="nucleotide sequence ID" value="XM_025658693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL15"/>
    <dbReference type="GeneID" id="37162095"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="698"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="774"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="718"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="743"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="787"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH57126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="889" mass="95182" checksum="16B4D78CDDBE29F6" modified="2022-01-19" version="1">MMSRSQSSLGFMDAGRDDSPASGAQPGHQAPPSNSGPINLSGLVCNVRRTTGREPHPLVGATTTILGDKLYVFGGRVLSKSRPQLTSDIYELDLIRRHWTKIETTGDIPRPRYFHSVCALGDHKLVCYGGMSPALNVSKEPASNGSGGQEAQPEVVVMSDIHIFDVPSRTWTRVPATDSPQGRYAHCATILPSSAHFTSATAPLSAIHHNPASSNPHQGSIGVDIDGFGGAEMVVVGGQDSSNHYIEQISVFNLRSLKWTSTTHLGRSCGAYRSVVAPLVGMNVSDIGSAADDGEAQEPLEDSQVEGCPMLVYSNYNFLDVKLELQVRLPDGRLIEKPMQSQASPPGLRFPNGGVINGHFVVSGTYLTSSKQEYALWALDLRTLTWGRIDAGGSVFGHGSWNRGILWPRRNTFVILGHRKRSLVEDYNHRRINFSHVCMVELEAFGLYNNACRTTPTSGYISYSAPAVPASMQHKLTKLTSGGRPFTSASNELGRLAQSLPEMADMELQAVGGERIPVNSRILTRRWGPYFIQLLRESCDSGIAETATLRPAVAMYPSRNSSITITPSLGQNSNYSNSSTLVSNRSVTSKSLLANLEIPSAHSLSPTSRPRVLYLPHTVLTLQVLVYYFYTSSLPPAGSPLCTPQILCSLLQLARPYQVDGLLEATVERLHQVLDGRNAAAVFNAAAMAAGGGRGTGFTSGPGGTLEALNGAHAGNESSSGTGTTTSQSHLTSDSSDTEHGTSALSVASSASGVMGSRGIPLRINTNIFSRRHRSNAGVDRDREDSMSNASVSTSASTNTSFDHSDSEMGGDPTRPSHHRRNTDAELRPEREIWTGDLSSVIGLQKRGLRGLMEGRRLRERNTKPAGAADHVATAAVAAAPPPVSVAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLC3</accession>
    <name>A0A8G1VLC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_462231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512485.1">
        <property type="nucleotide sequence ID" value="XM_025661835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLC3"/>
    <dbReference type="GeneID" id="37165237"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH54563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="429" mass="49527" checksum="AC3128571D85D409" modified="2022-01-19" version="1">MAGKKGPVLPYRRGSDASEADFFDIPEEPCWSIIKRQLRYLKSPRAWLAIFVFVLFVLLLRREKPPPPPLPHIDYDRVDWSLYAYSQYATSSPYLCNALIVFDTLQRLGSRAQRVLFYPENWDVLVDDDRDRDSQLLAMAQEKYNVLLVPIDVQMVKAGSGPSESWDKSISKLLAFGETEFERVIHIDSDVSVLQNMDELFFLPPSQVAMPRAYWELPDIKQLSSLLIVLQPSYKEWYALMDKAQAISYGQVDSNVSSRVRYDMELMNERYADSALVLPHRQYGLVTGEFRKDDHRAFLGNEHEEWDPEKVLAEAKLVHFSDWPLPKPWVMWPQELLADMLPKCKVKPGTMHESGCKDREIWKKLYDDFRRKRRVCSFLLSGWCVLVANDGRQDVCKLLSYPAPNWPPREKPQGPPETAPEGVSVPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLI7</accession>
    <name>A0A8G1VLI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_307613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515558.1">
        <property type="nucleotide sequence ID" value="XM_025655391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLI7"/>
    <dbReference type="GeneID" id="37158793"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="98" mass="11083" checksum="4B4E0B245A7F8996" modified="2022-01-19" version="1">MRGKQEAGRGWYDLIEGSPGLAFVTLQFHSWSPLLRSGSCRSGSPSLLPRSFYRLLTHWFTWLLALLTIEEQSTPHVLPPVITADDVMAPCGEERWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM33</accession>
    <name>A0A8G1VM33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_490403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513235.1">
        <property type="nucleotide sequence ID" value="XM_025663660.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37167062"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1455"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="703"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1028"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1249"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="712"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="741"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1082"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1100"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1156"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1261"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH55313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1811" mass="198593" checksum="52FDDA674BEBBD9E" modified="2022-01-19" version="1">MSSRITRSAARVAADSLPSTGSGPSPANAAAGSASNRKRKAPARRDRSVDAPEQSNPSSPPRKAKRQRRATPPRAAQSPATTRRGTRNRPAMSQSGPSSHPAEDSSRNQTSPPSSRRKSSRSGKVSQDNASAAQSSPRRQKKRPSRASPDTIMKEAEEEMEDQELSEERDSSPPSDSHEGTIPSGLDDDDDEDDGDLFHNSLFGSRSPLGLQSTLRALSGMMSGMSSRLRDILCNLRMKDDPSIQLIALQELSDLLLVSNEDNLSGQFSPDPYVKELVALMQPSDFGEENPEIMLLACRCLANLMEALRGSVANVVYGGAVPVLCQKLLDIQFIDLAEQALSTLAKISVDFPASIVREGGLTACLTYLDFFPTSTQRTAVTTAANCCRNLPHDSFPVVRDVMPTLLNVLASNDPKVVEQGCLCVSRIVESFKHKPEKLEELIEPAMLKAVLRLLLPGTTNLIGPHIHTQFLRVLAITSKASPRLSVELLKMDVVDTLYQILTGVSPPANLEGTAVKMDSVLVMQALIHRPREQVFETLNVICELLPGAPNRFFLSADGLAGLPAEGDAARQPKSPKAKESEEKRRSLLVDCKTELKRFAMILLPTLTDAYSSTVNLEVRQKVLTAQHKMLHNLDASLIEEALRTVPYASFLAAILSQKDHPSLVSSALRCAEILFQRLEHVYRHQFHREGVISEIFKLAEGPLSTEKQGKPASDSSPAQDAAVDAKPSHGGNDAAGSAEDNGGDDAEGGDDYDEQDDEDNDDMSESASSSSFSSHALSARIENAMRDIVIRDARAFVDLYEASQGRDMRDKALETLNELKTLATQIEAFYAGEGEEDGLALFKKLATYFDGDALESITSSELLNSGIIKVLLDVFGDFQATSMREARAAFLQAFMGSTISEKAQSQSTATTPFGVLIHKLQDLLSRTEHFEVSTVSHNSLENTRSNAAYMLGKQLRLKLVADEDSDIPRTYRNIMVSIHAIATFKALDDFLHPRISLTDRPRPSRTRETILNQIANAARLRDQLAGGEFPTSDAAATPRASSNTGRPQRPGETRSGSNDSPAEGRDHSSRSRRSGRHQASGENEHENEPLECADERQMSDDEDPEDDGEDEELNAIVDDLEDDLSDDNGHDPTAVNMEVASSGKVTARKEDGTRVATPSQTTPASKSSASASSSAQNPPGGSSLAMAGRPFASYAAAMASIPTDWHIEFSVDGEPVSNETTIYRAVHHNRQHAEPNARNVWSAVHTVKFRRAPGPPPPEPSTLTQGTSGSTPRDDSNDMPASLNQDQTTASILHLLRVLHEMNTTLDDILAETKDLVALTPEPLAQFINTKLTAKLNRQLEEPLIVASSCLPSWSEDLARLFPFLFPFETRHLFLQSTAFGYSRAMMRWHNSQNDDNRNDHRRDDRPILGRLQRQKVRISRSRILDSAMKVMELYGSSPSVLEVEYFEEVGTGLGPTLEFYSTVSKEFSKKKLKLWRENESVHGDEYAFGKRGLFPAPMSEEQAASESGKKQLQLFKCLGKFVARSMLDSRIIDISFNPAFFRIAASSSSVAPSLGTVKAVDHDLAKSLLLLKSFADAKKAVDDNRTLSKAQKAQALQQIEVGGVKVEDLSLDFTLPGYPAIELIKNGSNIPVTNENVDLYVERVIDMTLGSGVQRQVEAFRAGFSQVFPYSALRTFTPQELVMLFGRAEEDWTIETLMDSIKADHGFNMDSRSVRNLLQTMSELNPQQRRDFLQFVTGSPKLPIGGFKSLTPIFTVVCRPSEPPYTPDDYLPSVMTCVNYLKLPDYSSLDVLRERLSVAIKEGQGAFHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM82</accession>
    <name>A0A8G1VM82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_487299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516501.1">
        <property type="nucleotide sequence ID" value="XM_025663445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VM82"/>
    <dbReference type="GeneID" id="37166847"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="99" mass="11405" checksum="BEFAA580376DE64E" modified="2022-01-19" version="1">MECFRQIARLVKSPFRREKQQKVLEIGPPTDFRKEELPAFFSDDDAATLHSRGSTLEKEKEAAATAMERQPSTRDKIKTHVRRLSVRVARPVSDAHDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMS5</accession>
    <name>A0A8G1VMS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_448006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516938.1">
        <property type="nucleotide sequence ID" value="XM_025659836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMS5"/>
    <dbReference type="GeneID" id="37163238"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034633629" evidence="1">
        <location>
            <begin position="17"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="66" mass="6733" checksum="2F52115D94EBD3AC" modified="2022-01-19" version="1">MRFFAVIALLASVAVARPAENGALNALNVQVMCLGRDDGLCVGGNITAAGNSCCPPLVCGSDRKCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMZ3</accession>
    <name>A0A8G1VMZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glucose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_459401</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516172.1">
        <property type="nucleotide sequence ID" value="XM_025661654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMZ3"/>
    <dbReference type="GeneID" id="37165056"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF123">
        <property type="entry name" value="GMC OXIDOREDUCTASE (AFU_ORTHOLOGUE AFUA_2G01770)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="554"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH58250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="847" mass="92882" checksum="8A8522214C29EB13" modified="2022-01-19" version="1">MGSITEAIGKRTTELSHDGRDVAITLAVCVFLATLITGLRFWLSRRRRPLFSMPESMTLVSLLLFYSYAVATYLILTIGHGGYPTSQTQSWRLTFTLKCIYYLRLAYATGLGLVKCSILMALFRSLAASSKAARHAILIIMAVCISWSLGATLISLLNCRPLSYNWNLQHSEGHCINRNAAFMAVSIIDVVTNAAILVLPLPRIIRTKITLPEKLVMISLLILGLFVVAITAVRTVTIARTDFSAVNDHGKMISIWTTVEWTVALMIANSPVLWPLLDWLAPFHSMENAPVDTNMTTSEQFDYVIVGGGTAGCVLASRLKQYNSSLSILLIEAGPDASNHPLVPDGSKAPQLLGSELDWTYETVPQKHLSDRVLSNHAGKALGGSTTINSGGWMRGIKEDYDLWASLVGDSRWSYQGLLPYFRKLEHHFDPSADPEVHGFDGPIKTESASSTGRRYPLRQMVQEAWNSVDVKYNPDINSGSPFGLADVVENRENGMRQMSSSVYTLHVEIMTETLVKRVLVEERGSQKVAIGVVLEDKDESQIMARQEVIIAAGAYRTPQLMMLSGIGPAEELRAYGINVVLDLPDVGRHFADHVAVSQWWQLKHPENGLAFGSPAFTDPAFFRGNPIDFVALDSVPLDGLRQALVKDDPNCNPDEHPLITSQRVHVETFTVYVAHNAQDPSIAVDGTHITTGVSCMLPTSRGSINLADRDVRSAPRIDPNYCATEADRYVLREGLRKLREVLCDTPAGQKMILSETVEEKYQPLGPDTGDEAIDDLIRRRAATLYHPTGGACMGKVVDGDLRVKGIDGLRVVDASVIPTPLSTHIQACVYALAEQAADIISGVCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNJ8</accession>
    <name>A0A8G1VNJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_373607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514705.1">
        <property type="nucleotide sequence ID" value="XM_025656089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNJ8"/>
    <dbReference type="GeneID" id="37159491"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF8">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="10"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="410" mass="46291" checksum="EEE72D9EBF108215" modified="2022-01-19" version="1">MGSISGDKVALVFGASGISGWAVTRSLLEYPTRSTFSRVIGLTHRPQTRGQLGLPDDPRLEVYSGINLRDSLDEVMTQMRETIPHLDQITHVYYLAYSNATAYTENVMDIKHINVSMTYNAVHACDTLCKNMAFFVLQTGTNHYGVAVFQHIDKLTFNTPLREDAPRVPSPYGDEIFYYGQVDLIREAAQGKSWGWCEVRPDQITGHVPSTTSMTTVEPIALYLSLYRYVYGHGATVAFPGTPTNYIYTFTDSSQDIISRAEIYLSVVKPHEANGEAFNIADTATPGPWYAKWPILAEYFGLKATGPTQEDYAAIDKWWYDHQDDYDRMCKEYGLQKRDIGPETWLFVYAGFKLLDRNREFSLDKIRSFGFTEERSVCKGHLLAFDRMAKVGVIPTRTQLLPSSGVQPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNR8</accession>
    <name>A0A8G1VNR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_448044</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517012.1">
        <property type="nucleotide sequence ID" value="XM_025659849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNR8"/>
    <dbReference type="GeneID" id="37163251"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052478">
        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF4">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="55"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH59090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="455" mass="50362" checksum="0669EDA8B5E44F70" modified="2022-01-19" version="1">MAFPHVLGVNLGGDSPPRLRSCAYNFGNRPDEASNPHSFLGDLISEQDLSHYAGVYFTVMNPIGDILDPRIFADRCHQYYDGGYSTDITFAAVAAGVACLGSFLSSDRHPRETDLVLYAKAILDDPASMRTLNIDHIIAWDMRAFYLRATSRPKIAWIASCTVMHLCETVGLHDEASIKKIASKAGAAALGLDADRLRRIFWASWAAHNMLSYEQDCSAVHFRSVTCQSFVPTPGSVADQFVRLVQCTPAPNSPFRLDSEPADLNEELFERLKAVTELKVTHPFLVVTAADIAFCFYRRLYQAQALPSDEFISLVIDCGNAGLKAAEQLANEGHLFWNVLGSVFQYACVLLAIDSPIASAHLGTVFKRLENLVKAADTTLTREALSIARHLLSLKTAKKRKELAELEAIEASFQSGLTPLEPEANASMPDISWELYWDQFFLEPYLPMFSGEIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNY8</accession>
    <name>A0A8G1VNY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_511643</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516999.1">
        <property type="nucleotide sequence ID" value="XM_025664615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNY8"/>
    <dbReference type="GeneID" id="37168017"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08278">
        <property type="entry name" value="benzyl_alcohol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF2">
        <property type="entry name" value="GROES-LIKE ZINC-BINDING ALCOHOL DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="21"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH59077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="391" mass="41650" checksum="07E8F55390CEA325" modified="2022-01-19" version="1">MADTQQITGRALVSHGPYQAGGWKLQNVTLRPLRENELLVEVVASGVCQTDLHFAGLENGHGVHYPRVMGHEGAGYVRQVGPNVTAARVGDPVLLSFSACQTCQCCRRGHPAHCPNFDPINFESTQANRVFWDADADLSTVSTEPNIFGQFFGQSSFASWTLVQEESVVNVSGLVEGREDLQLLAPLGCGVQTGAGAVIKAANAQPGDTVAVLGLGGVGLSAVMGARIAGCRTIIGVARNQARLELALALGATHVVRIDSNSDEHHVTEAVRALTDGLGADVTLETTGVPNLIAKGIRMTANKGRIVQLGTAPENAVLSIPIHEFMVAGKQYMGVVEGDVVPREFVPEMIEWVKAGLLPLHEMVGFYQAEDYRTAISDMKSGKTIKPVLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP02</accession>
    <name>A0A8G1VP02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_261219</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517044.1">
        <property type="nucleotide sequence ID" value="XM_025655027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP02"/>
    <dbReference type="GeneID" id="37158429"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF8">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH59122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="719" mass="81340" checksum="8696ABBA4FE6203E" modified="2022-01-19" version="1">MKPASKHFCCTICQRGFTRIDHLKRHQLRRTFQHLSPSFLHLGPLRARVWLILQCSSCANFNLVRQIPVSALIHAFSATSPLRVVITYAITTRTVPSAAIKRSLRQVKEAEGDMPCTSMKLRCDGLSPCSSCQKRNLRCNNERKQTADNLELVSGSASVERENYGASSDRGSIKFLLNGGTDSFTEEFLLPPRSDRTRGLEYHNQKGRQDAGQSMLNFRTGDPSDYAPAFVESDPASLSFFQDTFLDFFNGPFGNVNKIVGDSYAGGANFPAMVPPIPDPGLAFAPQPTYEPEEPYAAGLYQAILARAWSVPLDTQAQERLSTYLSFLLTPARIDKFVRMYLEYWQPSCAMVHLASLNVNTVALPLLAALVFMGATYTTDEQEKHAAKQVMDFVELYIFSSETFSPENEVALAFSGRRMFDGGNNDWIQFQNLQAGFIMVIAQYWSGSPTARNRAMENRFSEVIKVARRMSLPKCRHNQHQAVSEFQWIQTESRIRTMSIILLLDCAFSFFQNYPCRLSHLEVECDFPCAESLFALEHPYSDRHFQASRGITILEAFHNLFEEDPKDTMPSTPDSSASGSMASLTVLDMFILIHVLYTFINSHMSLLGPILRKTQNSHPKHLFSFDPPEKSQSRAIPDDLMLAHIRVALARWREHWMTLSNTLSSGEWASMGFFKNGYNFWLVSQLLITKKKSVDVVMQMEVNCEDKLQKLKVLLDEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP64</accession>
    <name>A0A8G1VP64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_512053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517239.1">
        <property type="nucleotide sequence ID" value="XM_025664637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP64"/>
    <dbReference type="GeneID" id="37168039"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="12"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH59317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="284" mass="32737" checksum="2BC3EF7203FC1EEC" modified="2022-01-19" version="1">MSTANLRPVEGYDKLAAFIEADPGLAIFRRFTKLNFKSILYYQAEIANLEEELDFLIQDDKDSQDEKKQLYPFSVRDLKEGNPTQWSKFQEARDLMEKFNHAIIQQRELMRLSTPDKCDLNVLREWLDRPEGGNMFFETAAEMDVYHKRNDGDIIALFSRHEGVDNLTRLIFNRVVPWFHKRWGEKYESNENGAWQYSDKKIKACTHFFSVIIAAVLPASSMIVLYFIKDTAIRMVTIMLYNIAFSLALGLMVRARRVEIFAAATAFAAVNVALISNSGDCQCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP78</accession>
    <name>A0A8G1VP78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Checkpoint protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_447263</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518616.1">
        <property type="nucleotide sequence ID" value="XM_025659684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP78"/>
    <dbReference type="GeneID" id="37163086"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14131">
        <property type="entry name" value="PKc_Mps1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000377">
        <property type="entry name" value="Checkpoint protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000131">
        <property type="entry name" value="Dual specificity protein kinase TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027084">
        <property type="entry name" value="Mps1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="455"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="234"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="387"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH60694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="796" mass="88006" checksum="402E10654003ED51" modified="2022-01-19" version="1">MSRAALSRSGSRRTSPEFQNSSAFRTNSSVARQYSPGDSSDDEVPEPKFSASVKALLDEDGLDVSPRLRGERMGSSAGSSQERRSRATPPQDHSTGSPAPRVVRLAPSLSGSGGRSRREGSLLSNSESADQDARTNSNDFITPAPRPRSVRINASRSHTRSPASVSPSQRRSAERSYVDDHGSAERSEDERKYRYEDDYAPRTGPSSVLRTRNPEDIGMASSLRVKRVGRLTGTFLNGPARRGVLRRQSEENNEDRELDANIDNADYHYKNTAKSSSPKVSWADPSPPLRTDEHRSYDRADGPFSRSSSPKSYGSHSKSTPGSSSEMSSKPSSSQEQPVFKVPLPPTLPSSRDQENEPPPTFKRTKPQGFNLLDKPEKLAVVYGDEKKEHGETPAGNGNSPRKILATRSNNTPHRPAPPPPKMSVLETATATGGAATASQSRKKRSQVSVNHKPFTRLDCIGRGGSSRVYRVMAENYKIFALKRVNLEDVDPTTLAGYKGEIDLLKKLENLDRVVRLFDWELNSDKHTLSVLMEIGESDLEKILTYRLNAEDARFDINFTRYYWKEMLECVQAVHDHNIVHSDLKPANFLLVQGRLKLIDFGIANAIQDNTVNVHREQQVGTPNYMSPEALVDSNASLGLPASVGKMMKLGKPSDVWSLGCILYKMVYGQPPFAKIAKYYERILAIPNPHVKIDFPAFGVGGVPVPPGLVRTLKRCLQRDQTLRPTVEELLGQRDPFLYPDAQLEGAVPVTQDMLNRILVNVVNHCRVRGIPKDEELAAWPAGFFAKIKAALEEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQF1</accession>
    <name>A0A8G1VQF1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carboxypeptidase</fullName>
            <ecNumber evidence="15">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_390304</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="15"/>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518722.1">
        <property type="nucleotide sequence ID" value="XM_025656767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQF1"/>
    <dbReference type="GeneID" id="37160169"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000121">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4 15 18" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034456075" description="Carboxypeptidase" evidence="15">
        <location>
            <begin position="35"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="475"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="589"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH60800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="627" mass="70403" checksum="C0E9CED7EAD217F5" modified="2022-01-19" version="1">MVSLSSRGETTSIPSMASWLISTLLFLSPSLVSAKSAADYYVHSLPGAPEGPLLKMHAGHIEVDPQNNGNLFFWHYQNRHIANRQRTVIWLNGGPGCSSMDGALMEVGPYRLKDNETLTYNEGSWDEFANLLFVDQPVGTGFSYVNTDSYLHELDEMSAQFIVFLEEWFRLFPEYERDDIYIAGESYAGQHIPYIAKAIQERNKNVQGKTIASWNLKGLLIGNGWISPNEQYMSYLPYAYEEGLIKEGSRVAKELEVLQSVCKSRLETGKNKVHLNDCEKVMNALLDKTVEDNQCLNMYDIRLRDTTDACGMNWPTDLEDVKPYLQREDVVKALNINPEKKSGWVECSGAVSSAFNPQKSPPSVQLLPGLLESGLQILLFSGDKDLICNHVGTEQLINNMKWNGGTGFETSPGVWAPRHDWSFEGEPAGIYQYARNLTYVLIYNASHMVPYDLPRQSRDMLDRFMNVDIASIGGSPADSRIDGEKLPQTSVGGHPNSTAAEEQEKERIKETEWKAYAKSGEAVLVVVIIGVLVWGFFIWRSRRRHQGYRGVWHKDMSGSSVLERFHNKRTGGADVEAGDFDEAELDDLHSPGLEREHYAVGEDSDEDDISRQHSRQASRAGGNHNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRD8</accession>
    <name>A0A8G1VRD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_9055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520748.1">
        <property type="nucleotide sequence ID" value="XM_025665773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRD8"/>
    <dbReference type="GeneID" id="37169175"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="170" mass="18459" checksum="79D8C42D9B9E26D4" modified="2022-01-19" version="1">MEIPPRPFPHLPQSDTSRSVFTITIKNRNSANIVRRSSTHAMCMPSPNQSSIKHLYTQILAAITPTHVQGAQPATFCNPNLTSHFPTHCSDSTLTWMSLSIHSRLSSSQLPRVVTDSHTMITQPRNSLSSSGIPICIANWSSATSLAPAVLLSAAHHYGNSSAPLIYSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRW8</accession>
    <name>A0A8G1VRW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_475667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518125.1">
        <property type="nucleotide sequence ID" value="XM_025662740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRW8"/>
    <dbReference type="GeneID" id="37166142"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034703851" evidence="2">
        <location>
            <begin position="22"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="170" mass="18990" checksum="F24E17BAA05876B6" modified="2022-01-19" version="1">MHVSPLMWLHAFLFEYMRVSHESMCVSYLWHVVWDYWATGIRKKLLLLFWYYNRCPTQDPTMKLSAIFLQASALLIATTLASPLPVPEDGSIRIPVKGAPAERNDGSIRIPVKGAPAKRDDGVSRIPVKGAPEKETYGVIRIPVKGAPAKREDGSIRIPVKGAPNKPTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VS07</accession>
    <name>A0A8G1VS07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HORMA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_388110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521571.1">
        <property type="nucleotide sequence ID" value="XM_025656699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VS07"/>
    <dbReference type="GeneID" id="37160101"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033597">
        <property type="term" value="C:mitotic checkpoint complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000002">
        <property type="entry name" value="Mitotic spindle assembly checkpoint protein MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="8">
        <location>
            <begin position="16"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH63649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="226" mass="25360" checksum="6360211199AC08D7" modified="2022-01-19" version="1">MSATKDKSKVHKLSLKGSAKLVAEFFEYSINSILFQRGVYPPEDFTTVKKYGLNMLVTADDQVKAYIKKIMSQLNKWMTGGKISKLVIVITDKETGEHVERWQFDVQIFGKHSKSQSSRTTGDKENAAPGDKDPQAAATVEKTEKEIQDEIQAIFRQITASVTFLPVLDGDCTFNVLVYADADSEVPVEWGDSDAKEIKNAEKVQLRSFSTNNHRVETLVSYRLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VS37</accession>
    <name>A0A8G1VS37_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative EF-hand calcium-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_360636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521468.1">
        <property type="nucleotide sequence ID" value="XM_025655559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VS37"/>
    <dbReference type="GeneID" id="37158961"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF7">
        <property type="entry name" value="SERINE HYDROLASE FSH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="260" mass="29026" checksum="D24CEC1D45A12088" modified="2022-01-19" version="1">MSPPIRVLGLHGKGCNSEVFRSQTEIFRRLLSDLPVQYDFPDAPLPSPPAAGVGIVYEPPYYAYWHSDNLKSIEDSCSWLRTYMTRNGPYDAVMAFSQGAMLVSSMLLQDAAGISKALSPVKAAIFFSGGPPLTVMDSLGFDIPEDTWERDRISRLTLDVQPHHQASKETWQGPSLAKYEITEEELRADIAGPWTITIPTLHVYGSKDPRYEAGVELSALCDSTRRQCYTHDGTHEIPRSPIINEEIAKLIRTLLCNLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VT35</accession>
    <name>A0A8G1VT35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_495521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521484.1">
        <property type="nucleotide sequence ID" value="XM_025663935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VT35"/>
    <dbReference type="GeneID" id="37167337"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="372" mass="44660" checksum="F9ACECB889A0281A" modified="2022-01-19" version="1">MTEHASPTEDQALHQPYGQFILFGDSLTEMSSSQNDGFGFHAALQHDWLQHLTRLYNAFKGAEEFIVRSVVLRQFDADLLHDVLATHASSKIQDWSIDQAEKFLTPYFARDQHHFVDSMEWKVSQARSIGRFDGTVQYFVDHIVTKFLSTYTYWNDPQVVPPTKLERNRISRSLYRFETFCNLYPFWKYALIYDTGKLYIDNFAPWENEQLVCVSESLYEKFILPELTLRKQILVLLDPKLRSNWPELIPQFTSWIFQSYVESHLFRGLTHIRRFALEKDTDLLRKSYETPNLDDFNPEDEEKYIPRPWFRDPDSGPENIWRWANQRNQRKHFFAARNAQDLRSWLYVMWDRWRIDEMRVLNKSRPWPYGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VTD3</accession>
    <name>A0A8G1VTD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_501132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519610.1">
        <property type="nucleotide sequence ID" value="XM_025664159.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37167561"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904091">
        <property type="term" value="F:non-ribosomal peptide synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="575"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1674"/>
            <end position="1752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH61688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2187" mass="242267" checksum="3314591A94266D56" modified="2022-01-19" version="1">MSTKTRKPDKKDTDASSFQDIPEGDLRKIWKWNEVCPPPIMRCVHEICEEKARGQVDALAISAWDGELHYGELIQLVTKLAKWLFLSGIRPGMIVPLCFEKSLWTTVAMLGVLKAGAAFVMLDTSLPEQRLQAIVESVNAIMILSSVSSNTIAASLAETVIAIDSTFFSALNNLGGQDPPPVDPSSLMYLAFTSGSTGSPKGLLITHTNYASSLHYQLPLLGFTKETRFYDFSSNGFDASLSHTFTILAAGGCLCVPSEQDRRNSLAQSITSLRANAIGLTPSVARLLNPADTPTLATLLFFGEALRVSDVQRWWDKVRISNIYGPSECTPYSVINTSAASPQETTRLGKGAGLVTWVVDPDNHDCLLPLGETGELLLEGPLVGEGYLNDAERTARVFIRDPVWLRQGGPYHPGRCGQRLYKTGDLVHYNNDGSLTYVGRKDTQIKIHGQRAELGEIEFCLEQHLPQAKQVIVETITVKQEESSTVLAVFILPRQTSANTEGPGMTSMEIYHVPLDVIQVLAESLPAYMIPSFFLSIREFPRTMSDKLDRKKLREAGTLWFQQCVKDQSHRAKTKPTSPVGIELQRIWGDVLCIDSVSIGLQDSFFRLGGDSIAAMKVVSKARLAGIGLTFSEVFQYPTLGSLEGRCRLEHAKPIESIPPYSLLGKGWNEALLQDIMTYYQLDPDTVEDAYPCTPLQEGLMYLSLQNPGTYMMQRVLELRPDIDTRRLCCAWDKTTQSTPVLRTRIIQHTDIGFLQVVLREDIQWNHAKSLQQYLEKDKATPMGFGKPLVRCAIVTDEEANRRWFVLTLHHALYDGWSMPLLLQRVRDVYHGMPKGPTQPEFKAFIKYIQGQSHERAVGYWRDNLAECDCEPFPCLPSSVQRVKTDSEITHKLSSLKLHTLGFTPALPVRSACALLLSHRTNSDKVVFGVTTSGRSAPITGIEEIVGPTIATIPLYVKIQQSQTIMEYLESIQGQITTMIPFEQFGLHNIAKTSPGARRACMFQTLLIIQPEETAKADNTFGEWEGWQDPEWDNTYALVLEVQLGTGHVSARFDSNMIKPWIVQDLLEGLDLVIEKLATAQSDRRIADLDLVTPQSLERVWGWNRIVPSLVKATVNELVEKQVEQQPTGMAIHAWDGDLTYVELNQLATSLATELARLGVSPSLLGPNNVVPLCFEKSKWAIVTILGVLKTGASFVLLDPSLPESRLRSIIQTVGAKILLSSEANMDLSRLLSKMVIQVGPDLSKVPGHMGNHTKNITGQSPLPSSLLYTVFTSGSTGTPKGVMVSHENLCSALHYQSELLNYTVRSRVLDGASYSFDAAIHNILTTLVVGGCLCIPSQESYKGDIGSAIAAMRPTICNLTPTVARLLNPERAYDLETLILLGEPVKRSDIDRWRSSNVRVINAYGPAECTPISTINARPSNTEEAIRIGKGTGVTTWIVHPENHNRLVPLGCTGELLLEGPLVGLGYMNDPEKTGDAFVEDPEWLLTGSTSHPGRRGRLYKTGDLVQYNEDGSLSFMGRKDNQVKIRGQRVELGDIEYHVSASLPTKANQVVAEVVVLENDGEPKPVLVAFIHSDNNAISSSKETTVTPKLYQMTDEVMQRISRRLSIIPDVFVSMQKLPLTPTGKINRKQLREIDRSLLLSEEHVFDGTSDPSHSGEDSQGNLILQNDHPAYTIAQKVYSMRPSWMKNGDRNAKTGYRDISLHSSGLDSVNMMELTSFFSRHFNIQVDMQYVMAKTTTIRSLAEYVLHYQKNGTSPSSTKHTSTGVDLMREINRHDSRIRAAQLTLLGSNNPTFKHPSICRDKGSFTVFLTGANGFLGTQILRQLLSHPKINQVICIVRGNTDDAARERTISMAKEALWWTGHHAEKLEVWRGDLTLPKLGLDPARWESLSCGQTVDHIIHNGATVHWMKGYDVLEAANVGSTMELLQVALRCPRMRFVYITGGRPWKAHEEEDVVAELSAPDAIPYSQTKLVSEVVVRRAATRKLPGSSTPTPAGNICVINPGWVIGTPIEGYSNTTDYIWRLVATCIRLGVYNAEDAEGWLFISDATTTAEAVLDAAFSTSSDIIGDEYATQGMAWREFWAILQEMGYTLEGVSLASWMDLVGADIETAREQHPLWPLKHVYGWLQGNERVAGRTRGQSGDTPVRLKVAVRMGAEFLVRVGFLPAPTGIFQRNWVNGQEVIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VV46</accession>
    <name>A0A8G1VV46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_360640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521410.1">
        <property type="nucleotide sequence ID" value="XM_025655560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VV46"/>
    <dbReference type="GeneID" id="37158962"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH63488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="138" mass="14706" checksum="45DBE5B9AE9AE6AC" modified="2022-01-19" version="1" fragment="single">VDDHHTTEDTFLALGSAFTEALGARQSLARFGRGDAPLDEALSWAVIDLSSRPWAVINIGFRREKIGDLSTEMITHGLQSFAQAAGVTLHVGCTYGDNDHHRAESAFKALAVAIRTACTRRVEGEVGAGDVVSTKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QP64</accession>
    <name>A0A8G1QP64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Na+/H+ exchanger family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_433074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825097">
        <property type="protein sequence ID" value="RAH51656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509578.1">
        <property type="nucleotide sequence ID" value="XM_025658406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QP64"/>
    <dbReference type="GeneID" id="37161808"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562">
        <property type="entry name" value="NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562:SF2">
        <property type="entry name" value="SODIUM-HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="26"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH51656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="503" mass="54573" checksum="F83BAA5884693C32" modified="2022-01-19" version="1">MAGGFLPYHEPGIVNVLILISFFFFLSLAEWISSKIIRAGIIGQIAVGIIYGTPLANILHEDWQSTFLALGYIGLILIIFEGGLGARLDLLKKNLFLSMIGAATGVLFPIGLSYLLLYLGFGYGAVETFIVGASLSATSLGTTFAVISTASSTVDLAQTRVGSILVSAAVIDDVVGLVMLSVISDLGYLSQGHSVNLGWLIGRPIVASIGMAIVTPLVTKYLFAPLFRRYIEYHFARFDHISNIILMILVLCAFISIAAYTGTSILFGAFLAGTFLTYIPSKHPDGPFVVMSREEGEREENKSPTFVHTFERYLLDVQKYLMEPLFFSSVGFAIPFVQLWTGKRIWRGIVFTLLMLFAKLIVGIWVPLWQLLSSSNLLNRKTAKEFPSEEYPSEEYPSEDSKNPVWSTICLSGLLLGSAMVARGEIGLLVVEVGYNETSYVSEDAFITAVWAILLNTVLGPVTVGLLVKFHGKKIEKGAWGLQWAVPAGGGGSGDSSIDSSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QPI7</accession>
    <name>A0A8G1QPI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_454527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825092">
        <property type="protein sequence ID" value="RAH51851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509773.1">
        <property type="nucleotide sequence ID" value="XM_025661306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QPI7"/>
    <dbReference type="GeneID" id="37164708"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH51851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="197" mass="21803" checksum="7C76299F8A5B2D55" modified="2022-01-19" version="1" fragment="single">MQICVGEESKWIARPPLLGGRVKMVQAFKGKKAGWADVSGRGIRARRTPTFSCSSRPQFNAGSVHSPISDLILLFIALPSPHLTSPISLVNHCGRWSTDPGRVSVIIPTAASHFEAVGRSTSNWLTVQIGSIYVSLIGYGCQTWDRHRELEILHLRAKQCRIYRPRNSSLSAYVPLATPFCIVMAEMYSGLHVGQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QR21</accession>
    <name>A0A8G1QR21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_524231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510658.1">
        <property type="nucleotide sequence ID" value="XM_025665403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QR21"/>
    <dbReference type="GeneID" id="37168805"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH52736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="420" mass="44988" checksum="CEC36F3E9CD074AE" modified="2022-01-19" version="1">MDNVFDAAVSIALPTIQQEFNVTSSNLQWVISAYTLTFGGFLLLSGVLSDRYGRRWILCTGILWLSIWTIAVGVGETFLQLAIFRAFQGIGAAMTVPSSPGIIGSYYVGKDQSRALSVFASCGALGFCGGLIFGFFVLPKDRKEDGTRPRLDYMGAALSTAGLVLLSFVLSSGGVQGWNRGFIIGLLATSVVLLIGFVSVEKKVSNPTMPLSLWKLPHFPLLWLSAFAVYGSYQTTLYYAVLAAQRVSHLSAKQTAICFLPMGGCGLILTMLLGYLIDIVSPRMLLFFGMSMAVVAPIPTSVGMHENMSFWTSLLPTSILGIAGISLSWVTVSTVMLSLVPVNVKSFCGGMINTAFQFGAAVALAIAAAVTQELDIKHGHGVVQEYRTGLWCSAVTAGVGLLFSVLSLLGPVMKWLRQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QR36</accession>
    <name>A0A8G1QR36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_453666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NDUFAF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510688.1">
        <property type="nucleotide sequence ID" value="XM_025661103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QR36"/>
    <dbReference type="GeneID" id="37164505"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05125">
        <property type="entry name" value="Mth938_2P1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1230.10:FF:000005">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone]alpha subcomplex assembly factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034095">
        <property type="entry name" value="NDUF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH52766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="236" mass="25424" checksum="8784F51220431950" modified="2022-01-19" version="1">MHPPSPQLLRALRTSISPNCGASAICTQLASRSISPLARIISSPLTFSRYNSNDARPTRMIPRAHSAKPSSRDRGPPSKENTQTDFGALNVLGNIPAPTTAIDATLDTGFHLDNGVKITGGNGVFLVGGEAFVWRPWQGAEAGKNSMVNQKGQFEVPEHAWGILDLVWPRPDMLIIGMGETVFPLSPETKRHINSLGVRVEVLDTRNAAAQFNLLATERGVSEIAAAMIPIGWKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QR88</accession>
    <name>A0A8G1QR88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannosyltransferase 1, CMT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_454211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510071.1">
        <property type="nucleotide sequence ID" value="XM_025661227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QR88"/>
    <dbReference type="GeneID" id="37164629"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 69 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="59201" checksum="980932838E08E732" modified="2022-01-19" version="1">MGRFTRGWYEPVARTSFDDAEEIELARDDSIDGYPTRARVSRIGRLLALLFQTSRAAKWRIRRRYSPDTFTVRRIVSILFCVLVGLIVTTFALFPSYTHLPPHYRALQSAVQDSTTPGRGNPHNSTVFIAVSLYDKTGTLAGGAWGQSLLDLIDMIGPDRVFLSIYENDSDATGEQALSALSDRVPCNKSIVYDKHFNFTGFPTVTLPDGSSHVRRVAFLAEVRNRALRPLDDLNHRFDRLLFLNDVYFDPLDALQLLFSTHTRDGRPDYRAACAVDFINPFKFYDTFATRDLEGYGMGLPFFPWFTTAGKAQSRSDVLQGTDAVRVRSCWGGMVAFDAGFFQRGVSAARDTDQPTYYRGRRVPVQFRGEEDLFWESSECCLIHADIQSWPSSSSIGAAEAERDGEEDSGIYMNPFIRVAYHPRSFSWLRITRRVERLYSIAHWLSSTAVGLPVYNPRRAEVPGEEVQETVWVGDNSKEGGSFSQVTRIANYDGFCGRWDLQVLSRREETGEGGWVSVPVPALPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRP1</accession>
    <name>A0A8G1QRP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_408092</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825085">
        <property type="protein sequence ID" value="RAH52374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510296.1">
        <property type="nucleotide sequence ID" value="XM_025657388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRP1"/>
    <dbReference type="GeneID" id="37160790"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="255"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH52374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="357" mass="38922" checksum="AB86F9D368EDD5A0" modified="2022-01-19" version="1">MLHFRTEGFNGCAVKYSPFFDNRLAVASSANFGLVGNGRLYILELTPNGIVPYKWFTTQDSLYDLAWSEIHENQVLTASGDGSIKLFDTGVADFPIQNWKEHNREVFSVHWNLVAKDRFCSSSWDGTVRVWTPNRPHSLLTLPTHSCTYSAAFSPHSPDILSCVSSDSYLRVFDLRTPASASNHLTLQIPIHGGGAAAGGGIVPGGGPMAATAPAEALTMDWNKYRPSTIATAGVDRTIRTFDIRAPGQGPQTVMLGHEYAVRKVAWSPHLSDVLLSASYDMTCRAWSDQTPPGAVGDVDVMRAGPGPNMGVELGRMGRHTEFVTGVDWCMFGSEGWCASVGWDESLYVWDVRAVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS78</accession>
    <name>A0A8G1QS78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_433148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825099">
        <property type="protein sequence ID" value="RAH51629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509551.1">
        <property type="nucleotide sequence ID" value="XM_025658409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QS78"/>
    <dbReference type="GeneID" id="37161811"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH51629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="379" mass="42156" checksum="2CBFD3342D0F9741" modified="2022-01-19" version="1">MSLADSRLFHPLKVGNVDLQHRVVLAPLTRFRADDDHVPMPITVDYYAQRACVPGTLLITEATYVSKRGGGMPNVPGIWNKNQIAAWKNITDAVHKQKSFIFMQLWALGRVAVPQIARDEGFDIVSSSPVPQANPMSPEIVTPRELTVHEIKQFIGDFVQAAKNAMEAGFDGVEIHGAGGYLIDQFTQDTCNRRNDEYGGSIENRSRFLLEVARGVADAIGAEKVGVRLSPWQSYQGMGIKEPIPQFTHVICGLKELKLAYLHLIEARVNGTEDVDKHDSNTPFIEAWGKISPIILAGGYTPSSASERLDRQDKEENLLIAFGRHFIPNPDLAYRVKNGIPFVPYDRSLFYMPKSEKGLADYPFSAEFIRENEKGSSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSD4</accession>
    <name>A0A8G1QSD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cyclic nucleotide-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_170703</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510680.1">
        <property type="nucleotide sequence ID" value="XM_025654289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSD4"/>
    <dbReference type="GeneID" id="37157691"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000057">
        <property type="entry name" value="Cyclic nucleotide-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000467">
        <property type="entry name" value="Cyclic nucleotide-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000174">
        <property type="entry name" value="Cyclic nucleotide-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF24">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G03170)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16643">
        <property type="entry name" value="cNMPbd_u2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="63"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="265"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="536"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="434"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="483"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH52758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="919" mass="101924" checksum="896DEA627EBBF3D0" modified="2022-01-19" version="1">MRRHGRASGGTKAVHPISDTASLLHSFDSITNPNRPVRPSPLTSSNIQALPLDLVDRLRSFPLFQSTPESFLVDVGQHLRPQLHAPNDYILTEGDEAKAIYWLVRGAVSVTSRDGESIYAELEPGAFFGEIGVLMDRPRTATIIARTRCLLVVLTKEDFRKILPRFPDVERAIRDEAQERLMILEKKKKETSVPSVDLVSPIRRGSKRLRDTYSGDLNLADQDGRSLKSVNKKRKSPSPGLADGSSSALANGLVNVRLLLKELPLFSGLPPDILHFLGLNAQPRSYPPFTDIIKQDSQGREIYFIVRGEVEVLSERTPNHHAQSLPNKIEHPSFEVKARLKQGQYFGEVVSLSLAPRRTATVRSISAVECLMISGEVLVEFWERCPPKVREQVERTAKERLQAASDGDVVMSEAGADEQPLSVDDNFKMRAGRRQSMPLLTLTETELDSTPTANGLDEPSVLRPSDPDPFLSVGLDKVRLRSRRSSVAPLTPEEVSGEQQRSSPSSEPRSTSSSFLTLPGAGEFSTPSETVREPRQDNHGYLPDQVLLVIFQHLELHDLLRLRAVSMHWSEILSKSTELLHHLDLSTYNRCVTDDVLVKIICPFVGSRPRYVDISNCFHITDEGFSKLVATCGSNVVTWKMKSVWDVTASSILDMASKANNLQEVDLSNCRKVGDTLLARIVGWVSPGQHKPHDESKSGKASMKPTRQTAAGTVYGCPELKKLTLSYCKHVTDRSMHHIASHAASRIEEMDLTRCTTITDQGFQFWGNARFTNLRRLCLADCTYLTDNAIVHLTNAAKQLRELDLSFCCALSDTATEVLALQCSQLTYLNMSFCGSAISDPSLRCIGLHLLNLKRLSVRGCVRVTGAGVEAVADGCNQLTSFDVSQCKNLLPWIEGDGPRKYGKKISFETVAQNGRVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSE1</accession>
    <name>A0A8G1QSE1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Crh-like protein</fullName>
            <ecNumber evidence="16">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO85DRAFT_170761</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="16"/>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510686.1">
        <property type="nucleotide sequence ID" value="XM_025654290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSE1"/>
    <dbReference type="GeneID" id="37157692"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000159">
        <property type="entry name" value="Glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034997891" description="Crh-like protein" evidence="19">
        <location>
            <begin position="21"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="20">
        <location>
            <begin position="17"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="347"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="371"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="17">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RAH52764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="425" mass="45607" checksum="D651A3AA3AE876DF" modified="2022-01-19" version="1">MVRYTSSILLASLAATSVWAASSPPSCSTSSQCPEEYPCCSQYGQCGTGAYCLGGCDPISSYSLDSCVGEPVCQSKTYKWDSLDSAALNTKYLGNASEYDWVYSGYPKLDDGNLLLTMPKNTVGTLFANNHYVWYGKISGKVKSSRGAGVVTAFILLSDVKDEIDFEWIGADLANVQTNYYWQGVLNYNNGDKDAVNGSDTFDDWHEYEIDWKEDAITWSVDGQVKRTLTKESTWNETAKRYQYPQSPSRMQLSLWPAGQASNAPGTIEWAGGEIDWDSQDIKDKGYYYATFSDITVECYDAPNGTVSNGNKSYMFTNKDGLQQSVQITNNDTVLASFGATGLDMDLGASDSSSSGTNGTVPENQGGSGNVPGSSSSTTSGSSSTSSGFSQGSSTDTSGAPSQNERVMRGSFFAALVAVVVLVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTE1</accession>
    <name>A0A8G1QTE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoenolpyruvate/pyruvate domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_453144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511256.1">
        <property type="nucleotide sequence ID" value="XM_025660994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTE1"/>
    <dbReference type="GeneID" id="37164396"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF2">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="204" mass="21852" checksum="E19932B8CDF22222" modified="2022-01-19" version="1">MVHRTVTEYIRAGVAALHLEDQPTSKRCGHLRNKQLVPEDEYLDRIQAAVNARARSHGDIVLIARTDALQSLGYDAAISRLKGAIALGADVAFLEGITSTDQARQVCEELKPTPVLFNNVPGGVSPDLSVQQAQELGFRLIIFPGLALGAVYSAVRGAVQQLKQTGTQAVRAGRSPRDIFNVLGLQEAVALDLASGGRLYDKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTW1</accession>
    <name>A0A8G1QTW1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_492082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511490.1">
        <property type="nucleotide sequence ID" value="XM_025663758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTW1"/>
    <dbReference type="GeneID" id="37167160"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="592" mass="65239" checksum="61F8E4518DA7C328" modified="2022-01-19" version="1">MPLSDADQRQYPAYEPLHNECDDPDILSSITDAETRQDLEGHEDVGLHAVSPSNTPDENGESNSDTTSHSPTLGEPSNYKDEKPNGPETVSVRRYTSSWFYWELTGIIVSAALLAAIIIILKVYDHQPQPKWWHISLNSLKWDWFAQQEQPLSHLQSFDSASRGALGSLTLIWALRVQRFAGVGALAMVLALGFDPLSQLLIHTYDKLVVDPSGTALIGNATVYDTIGQLAYDKGTSVAYVDPVLKGNVYNSLFNTDPTRPWAIPQYSCSLTNCTWDAIASLEMRSLCSNITSALITNCSTFSNESVYAEKSNCNVTLPKGGLSASYTPAPRANLELLDDKRWSNSTQWEATECSLEPIVRSFRPKIFHNHYSDKTQAIWIQHNMTTTYNVHHGDARKSIFYFLTAIFSGQATRSATGIFFDPLDSSWYAASDTLQALAVANISGCSEILSERLSCAMDNVAAAMSKTFRDAAYVADPASAAMTTGSAKVSEVYIVVYWAYLALPVLVWTLGAILVSDTRVWLQTLSKIAPARHSSYVRFAPNKKSPDNAPRVLFPIQRKAKNRLAELAAAFLCLPVASVTNIVHDDDLRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUG5</accession>
    <name>A0A8G1QUG5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_453464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510989.1">
        <property type="nucleotide sequence ID" value="XM_025661059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUG5"/>
    <dbReference type="GeneID" id="37164461"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="174" mass="19664" checksum="5CC042389B608A1F" modified="2022-01-19" version="1">MARKFPVDSAGPDIVRDYIITTLIRKHEATPEYAEKLATSWQLGRVRELRSATLKHLQDDFGNDVGLCIYRSIREDMLEDWQETTAAAVTIWSVSTATMIHLVVVGLFILPELGLMQPCERIRVAKSPASWLLFGFAWLNYHYQRQDIEEPGHISLAGPVGLLSISVGLYLFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUS0</accession>
    <name>A0A8G1QUS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_490928</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512653.1">
        <property type="nucleotide sequence ID" value="XM_025663684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUS0"/>
    <dbReference type="GeneID" id="37167086"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003312">
        <property type="entry name" value="PRK04313.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH54731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="258" mass="29024" checksum="A729856873ED2638" modified="2022-01-19" version="1">MPRGPKKHQKRLSAPSHWLLDKMSGTYAPKASPGPHKLRDCLPLIVFIRNRLKYALNGRETKAIMMQRLIKVDGKVRTDPTYPAGFMDVIGIEKTGENFRLIYDTKGRFTVHRIQAEEAEYKLCKVKRVQLGKGGIPFLVTHDARTIRYPDPAIKVNDTVKIDIATGKIADFVKFDTGVVAMATGGRNMGRVGVVTHRERHDGGFNIVHIKDAIDNTFATRESNVFVIGQDKPWISLPKGKGVKLSIAEERDRRRALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV80</accession>
    <name>A0A8G1QV80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_379607</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512201.1">
        <property type="nucleotide sequence ID" value="XM_025656349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV80"/>
    <dbReference type="GeneID" id="37159751"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="70"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH54279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="419" mass="48036" checksum="F75F34B980A57224" modified="2022-01-19" version="1">MYFSTIRNGLSLIKYNKLISSQATVFNCKRAIRSRAFASKPEELLEEKLPFYKPNQFYPVHIGETLNSRYRVVGKLGYGSYSTVWLCHERRYVAVKVLTKNDSSKTLSGELRIYSHLSKINSSHMGGSYIRGLYDTFDITTSDGTYPCLVHPPMHMSLHDLRLLSSSRRLSEFLLKETLKCILQALDFLHREANIIHTDIKPSNIMLSIGDPSILTDFEKSEQQTPTLKKTIDSTRSIYTSRKLRLPRDMLWGQPILCDLGQARIGPSHRGIIQPNIYKAPEVLFDMEWGFSVDIWNLGVIIWDLFENKHLFNALDEDGDYSPSHHVAEMVGYLGLPPLTFIERSRETRNVFTDDGKWLGVGGVTIPATSLEEIGENLSGKNQELFLQFIRSMLQWEPERRKTAREILDDPWLNSTSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVG0</accession>
    <name>A0A8G1QVG0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_452029</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512505.1">
        <property type="nucleotide sequence ID" value="XM_025660728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVG0"/>
    <dbReference type="GeneID" id="37164130"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF8">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YRBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="8">
        <location>
            <begin position="138"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH54583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="282" mass="30157" checksum="4E529461146CD6B7" modified="2022-01-19" version="1">MGSTISNILGAFSLGLLFYPRGLEFDRSAKLYSALLFIVTTLFVMLAFFNQLNHIVGGVLIAIFALYIVSIIYAIYKGVASPPELSDSDSDGESSDSEDDEFANHAPLSETSPLIANDHAPSSTDKGSRRCRSFPYHIFQLILGFISLSLSGYILSHSAVTIADSLHLSGTVFGLTVVSFATTLPEKLVAILSGSRGHGGIMAATTAGSNIFLLTLCVGVVAVAGYPAQEADNFVLFELVAVWLSSLVFCAVIFLGLGRSAGVVLLVTYLVFLCLEFTVYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QW67</accession>
    <name>A0A8G1QW67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_426970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512614.1">
        <property type="nucleotide sequence ID" value="XM_025658140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QW67"/>
    <dbReference type="GeneID" id="37161542"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF8">
        <property type="entry name" value="DUF4220 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="416" mass="46950" checksum="E35A8DCE803B97CE" modified="2022-01-19" version="1">MAPLPEGEVSGWVDSPNDRGTIDIIWGCCLVLSTALWTVLHLNIPAPDDGLWTVLWRKLRWGTFAILAPDMLVGFSAMQYESAQESVRDMHRLGYKEWTLKHAFYANSGGFVLQSTDYPPFPITAASIHYLVETHHIDCPTITAEEIWDKSKADTFAKCVALVQGVWLVVQSIARAVQGLAVSPLELFTIAFVLSTIMTYYFWMHKPQSVGVPTVIELKSGSVTSLINSAGEIGVEPFRETPLDFLEKPHQRWHRRPTLENLRPQKSPLQRMPDDKIVFNGLSQRTWLLVSIQAMVHPAVHLLGWNHVFPTSTEQLMWRIMSVFLASGLPLSSMLRITLTALGFDGHQSLTWIWVQPSGKEEKGWRAWVLDVVMSFISACLVPARLFIIIEAFISLRQLPSSSYVTVEWTSFIPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWJ3</accession>
    <name>A0A8G1QWJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_378064</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512809.1">
        <property type="nucleotide sequence ID" value="XM_025656286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWJ3"/>
    <dbReference type="GeneID" id="37159688"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000002">
        <property type="entry name" value="Vacuolar sorting-associated 74 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH54887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="353" mass="39452" checksum="573D6806FE137E1A" modified="2022-01-19" version="1">MASAGGLTRRRGGGRVAGAEDNDDSRVSSPVSRNGSSLDNRIPETSFTSSENGHKIAFDPRDISETEERSKQPKLTLMEEVLLLGLKDKQGYLSFWNENISYALRGCIVIELALRGRISMQKDSSRRRFPLADRVIEVVDDTLTGEVLLDEALKIMKSSEKMSVNSWIDLLSGETWNLMKIGYQLKQVRERLAKGLVDKGILRTEKRNFLLFDMATHPVADGGAKDDLHRRVRNVCSSRTVILPANAWLPEDVEFRYLRTITMVCAAYAANVLENALVTMSHEARERAFAQVDELLAEYSQWPFARRAGGSQAIGANLAQAINDEVNKSKDRELQMEIVAACLSVFTRLDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWU0</accession>
    <name>A0A8G1QWU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secretory pathway protein Ssp120</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_426710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513020.1">
        <property type="nucleotide sequence ID" value="XM_025658128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWU0"/>
    <dbReference type="GeneID" id="37161530"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034063890" evidence="2">
        <location>
            <begin position="22"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="199" mass="22761" checksum="81A06612D7F285F5" modified="2022-01-19" version="1">MLVVLATALLALSGSLVSAHGSHPDQPPSSDWATRHMQEEHHIDAFDAASFFSLHDYDESGAWTPEEVRKTYGMDDETNAGATEDRKSQALREVFTLFDPTNTGFITRDNWMRIIGEGTRLPDLGFGPGHHGDIEYEYEIHHFEKYHGEDATEEELTHPEDIEHFRRHDEEDLAMERLEQLESMQIVEANIPQKFLKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWV5</accession>
    <name>A0A8G1QWV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">HAUS augmin-like complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_489879</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513808.1">
        <property type="nucleotide sequence ID" value="XM_025663631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWV5"/>
    <dbReference type="GeneID" id="37167033"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026243">
        <property type="entry name" value="HAUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25762">
        <property type="entry name" value="HAUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH55886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32227" checksum="AE5F7C5935F12F72" modified="2022-01-19" version="1">MDSPLLSPAKARQAAIQAKDWAYVNAWLSRQYAPNPVPSFERNEDTLRTLLALAAANDTADEEATVLHQAREQAVESFKAREKNEEKQKVEILDEVEHNLDDNGRRNLDDLAETTAVLGALGTSTRDLGQSIIELTVEEFDAQQQMSRVQALHEYLGRELATLREQLLDLKTNEVYETPANLPALTAEWTRETKLLSAKAGEYHDRIASLQRNRIKGPTLEEVIAEEQSVIRMLESTETLVERVKKLHDLPSDIPGARAQYKELEQELDLLTQQRNTMSDKLADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWX5</accession>
    <name>A0A8G1QWX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_451542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513116.1">
        <property type="nucleotide sequence ID" value="XM_025660611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWX5"/>
    <dbReference type="GeneID" id="37164013"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="370" mass="41599" checksum="BAECF4F0C77CFBD6" modified="2022-01-19" version="1">MVVQASMEMGSSITYTDFQATLRAVVEQRSQQYQNIYSIAVRWELDDTNAELDTAHFQSMLKNFDTDPAEVLVLGSDDHYPVYTLSRAWLNFTAKARLNNERNLIIFHYAGHGATKNGSFNIVENMSEESKTADFERAILADVKNPKGFSDMVDVLFILDCCYAHYTTRAPKTTRNVIEILAATSSQTVTARSAPNNTFTAKLANEIARRKKAHHESVEFTSVFQSLLTRSSTIVRPTHALLVGAASVNIPLNGHRTVDPRAIPADYYALFAVNISKDITKEELKELSTWMRSLPPFTGLKIEHIYQTQTHSMCLIMRASFSVYTKLHNMQGYNLIAENPGPALTHLLQPELSEEPASPPSQRSMMSERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXE0</accession>
    <name>A0A8G1QXE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_499180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513244.1">
        <property type="nucleotide sequence ID" value="XM_025664060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXE0"/>
    <dbReference type="GeneID" id="37167462"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000009">
        <property type="entry name" value="Proteasome subunit alpha type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH55322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="255" mass="28274" checksum="46CE8C073F0DF4D5" modified="2022-01-19" version="1">MSRRYDSRTTIFSPEGRLYQVEYALEAISHAGTALGILAKDGIVLAAEKKVTSKLLEQDTSAEKLYTLNDNMICAVAGMTADANILINYARQAAQRYLLTYNEEIPCEQLVRRLCDLKQGYTQHGGLRPFGVSFIYAGYDPLREFQLYQSNPSGNYGGWKATSVGANNASAQSLLKQDYKEDCDLKEACAMAVKVLSKTMDSTKLSSEKIEFATVGRTPEGKIYHHLWNADEINALLKEHGLAKVDDEPEAGEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXE9</accession>
    <name>A0A8G1QXE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_492536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511062.1">
        <property type="nucleotide sequence ID" value="XM_025663780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXE9"/>
    <dbReference type="GeneID" id="37167182"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF1">
        <property type="entry name" value="OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="16"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="351" mass="37965" checksum="6D3D1F1A134A21A5" modified="2022-01-19" version="1">MATPTFKQFYLPEKKGFDSLVLREVSKPSPKQGQILVRIKAISLNWRDGIIALGTYPFPGPDALVPGSDGAGIVEEVGEGVTEWKVGDRVLANFTQDHIAGKLNKQSLLSQLGGEIQGLLGEYFIFPKLGVVKIPDYLTFEEASCLPCAALTAWNALYGLVPIRPGQTVLLQGTGGVSTFGLQIAHAAGATTIVTSSSDEKLAKAKELGATHLINYRKNPDWAVEAKRLTKGNGVDHIIEVGGTLTLQQSFDSIALHGLIHCIGHITNPDPLGAGKELRGPDAAFLALDRVCIVRGVVVGSREQLQDMLECFEAHSIRPVIDRIFDFGETRQAYDYLWSSSHTGKVVIRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXI8</accession>
    <name>A0A8G1QXI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NRPS-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_426984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512624.1">
        <property type="nucleotide sequence ID" value="XM_025658141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXI8"/>
    <dbReference type="GeneID" id="37161543"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="548"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH54702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1036" mass="114840" checksum="6D0173C24DB61042" modified="2022-01-19" version="1">MATTPGQRLLPVVVDHLAQANPAQRIGLIPTGADVSDGYDTVTVQRLARAVDAFAWWIEKQIGRAQEPKTIAYMASNDVRYLIFLLAAHKTGYKPLLPSTRLSDDAYQHILNATDCHAFFYTPEKQRRVSEIQAFRPDTTFHEVPSIAELFSTTSQPYLYTRTYQEAEDDVAIIIHSSGTTGMPKPVPLTHGFLATIDYAAYISRPQFRQSTLFHDLRPDTLVLSTTPFFHLMGLLAFFESLFHHIPFVILPEKPLSADLITSAITATKPAAAMLPPSLLEDMSHVPAARTALSTFEYVYFAGAPLAPEVGDNLSQLTKMITVIGSSEMGIISSLVPQGKNVWGYFDWNPAYGVDMQHVSDDMYELVIPRRADSRRIHGIFHTFPDLTEYHSNDLFIRHPEHPHLWKYHGRLDDVIVLSNGEKLNPITLEKIVEGHPRVHRALLIGQARFDTALLIEPNWALEGETIDEKAFIETIWPTVERANEAVPKYGRIAKNKIRLSDPKKPFQLTPKGTTKRHAVNNDYKDEIEAIYAAAEEETAAVELPTTLSIDNLRTFVRSLIANLLDRADLRDDEDLYAAGLDSLQTIQLAKTLNKAVVAAGYPAGQEISQQQIYGNPSITQLAVYLHDLVTGNLRTTTISRADRLAATIEKYTPQLPRRTTPVVPAPANSTVILTGSTGSLGTYLLHSLLTDSNVAKVYCFNRSDAADRQQRSFADKGLDTALLNPSRVEFLTVSFGAPRFGLSESKYADLLENVDFIIHNAWKVNFNHPLESFEDPHIKGVVEFISFSVRSRHNAHLSFVSSVSTIGGWTEKLGPVVPEKPVESVDAVLVQGYGESKFVGERLCLAASDGAGVPTTVFRVGQIAGPTSVKGMWNLDEWVPTLVKTSKSVGKVPANLGGYEVDWVPVDTLSTITTELMHTRRQNQSATPHAVYHLVNPCKTLWATLVPAIQTKYPGMQAVPLDQWLDELEAIKSPSETEVREKPALKLLDFYRGLAGEMLSASISVEQTRGGSKTMEGLGAVTGDLMGNWLRQWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXK2</accession>
    <name>A0A8G1QXK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-C homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_440382</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513476.1">
        <property type="nucleotide sequence ID" value="XM_025658764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXK2"/>
    <dbReference type="GeneID" id="37162166"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06993">
        <property type="entry name" value="cupin_CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000033">
        <property type="entry name" value="Centromere protein C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028929">
        <property type="entry name" value="Mif2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15624">
        <property type="entry name" value="Mif2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2 N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="8">
        <location>
            <begin position="497"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="409"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="587"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="617"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH55554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="631" mass="68803" checksum="3DABA00DB31B7225" modified="2022-01-19" version="1">MAPRGPAKAREFDYANVGKAGRRTGLMLKEGKRDEYGMEEVDGIFSSPETSPVKENGFSDQAEDSTGSDGMSIDEGNGPNPTDFLKSRRSSYFPPPVARSPMKTGLTGSPRRTPGLRSSQSPQREQPSSSPSDGKGLGSARGESRRDVSPLTSRSINAPPVLNQVNGARNNKINDEPTEEPMDSGFSDSDTENQLNRDENGHSFAQTHDDIMDSFNAGDDASTDDHADEQDDTGAELDSPVTVSESRSKRGQAKPVPRIVRGVKGARAGASTAAQAQEIEEEQPAPKRKRPGRPPRTQRKSGDEVEKERPSKKPRVSDKADKNPSPSGNAELDKVVENYVNRTGPLKGRSLYILKREVPSEGAATHTRSGRVSVRPLAYWRNERCVYGDGEAVEGQRYPLSTIKEIIRTEELEPEKPKSNKRRPNKKSKSRKGKNDDSSDEEDGYVDPWEKESGILHGYIRRWDEEAQAVGEEEEIVDLAYAPAGMETRSVKDSSWRFAKLLSSPFLGSGIVELPPGGVKKPKNSKKMHMVFYICQGRVQVDISGVRFSAGKGCVFQVPRGNYYSFANTQNKDARLFFTQGCVPVENDDSAPGSATKPGAMDGDSSTPTGRPTGVKGRPKGKQKAGGRKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYP8</accession>
    <name>A0A8G1QYP8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nonsense-mediated mRNA decay factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_489021</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in nonsense-mediated mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514768.1">
        <property type="nucleotide sequence ID" value="XM_025663574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYP8"/>
    <dbReference type="GeneID" id="37166976"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF36">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="4">
        <location>
            <begin position="57"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="3">
        <location>
            <begin position="188"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH56846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="865" mass="96132" checksum="49A17E710134DB6A" modified="2022-01-19" version="1">MPNSASYRTALEVEKELLKSLAEKEPTFAEISHYLSEFRSTCQNAILQDFETARSVDVEPRLWDAHLKINTRFRKLLSRFREESGKKKKPVERRKLEKHYLEFIKSSQRFYRAFIQQLSSHFGGIPELEKVARKFNSDNLSAEPPIRTSEALKRHILQSCHSTLIRLGDLSRYRETELVSKNRNWGPAIGYYDLATLIYPASGAPHNQLAVIALADGNHLRATYHLYRALAAQEPHPSAKGNLEIEFRKVMNAWVKRELIRPEDAGIPGRSLAPWFVYLHAQCYRGIDFPEHDELESEVLNQLAVDLKERSLEGTLQKFCLINIAAEEFSRTQTSDDSTSNARSFFQRINVKTFFTLLQILLAEVERFAVEDPSNKDAQTGPDKVTVVARRVLPALRNYSSWLLTASSLLVSYQGEKDSPLAVQIIEFWKIYANTLTLLASTFDVVHLPDIDYLLEEDEETLCFAPLAKEATSRRYFSSTGQQKPRMNDPGVERNHPNMEMLYRIREFVIDGLDLVVSNKIPIALVDDEDKKTFIYQEEGLPSQFFASPSGHHHTISSASIERDDIQKAAPDPSHNIDTRSVFGGSQAASASMSASMHRIVEGVERLVESDTYENAPAIPEQLAFPRSSNQQRPSSQFFDSSMDSIFQEDILPRQTPAAPPGLVPPVTGSAPLVRVSSSHSYAARPALPGIPSIWNTALSPELGDAPSPRTPPGLGQQYPASMLPGNIASPNHHLPSQDMIASENERMLRQSMMNQALRHSPLNGPSTIPSSWMPSPNSTSHHRLSGFSWDQSLVDAAANTPGSLGVSSQPMSSGLSNASWANNAFIASSFPSGAGFSSSGFTNTRRSATQYGAIGQTPPCGHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYS8</accession>
    <name>A0A8G1QYS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin cytoskeleton organization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_403077</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513016.1">
        <property type="nucleotide sequence ID" value="XM_025657209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYS8"/>
    <dbReference type="GeneID" id="37160611"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024660">
        <property type="entry name" value="UCS_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF1">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11701">
        <property type="entry name" value="UNC45-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UNC-45/Cro1/She4 central" evidence="4">
        <location>
            <begin position="226"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH55094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="836" mass="90773" checksum="B9513E7E30EB3EF9" modified="2022-01-19" version="1">MVHSTSEERAVHLTREAVELIDAGHREAASRNLREALSLAPEHPAVKEAFVKIQQEEENGHHLLDLCRRYTGGKDEPAGKDAALYLRTDGLKPPEEVALECVKLLLAQRPHALSSLQDDIISGLVRQNTSVRRYFSEQLQVSVTTFFDEIYERGDGAAVCLDTVVLDPTVWPSEDARLHCERELFLLFIAKLMESGHDMDGRSLKGIARLLAVDAAKLQELVDDEGLDVILSSLDSRLPLEWRSQATLATVKYLEISKQVGEERFSRLVTAKVVKGRSDDLIEAFSATAAVFPVIPEVAANLFLSESYLAALAPLTSRDAKSRKVEPHFLELLNAACMNKACREAISKHLSTWLSHLLTNGCDESSEMAAVILAKVRTAVQVGSSDSNGKVEEENSRVTELVDRFKDLMSKRKTENLSNVIEGLAYASVKSTVKEQLATDVAFLQDLVKILRENCTDSSVLYGGLMIIVNLTQFPPTLTEEQKKMSQLKSYAEASPSGARAKPDPLDDEQHVIARCNALIKAGVMPLLLDCGKTNLSSVQGLMGKIVLALSWDRKSRGTLAQQGAVKFLLVMAAAKQGTPGTNATEAVQNASQALARILISVNPVHVFPSSGFPQITSAIRPLTALLVSPETTSMTAEQPRNLLPVFESLLALTNLASHPDETAPEAIVRQAWPVVEDLLLSSSPMVQRAACELICNLMTCESGIVKYADGSKRAAQRLHVLLALTDTDDMATRSAAGGALAMLTEFEAAIAGILERPRGVPLLLAMCQEEDEGLVHRGVACVRNMTCLATGDIGRRAKEVIKANGGVNILSSVLKKTKNPAVLQVGVEALKPLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R001</accession>
    <name>A0A8G1R001_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_449748</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514935.1">
        <property type="nucleotide sequence ID" value="XM_025660223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R001"/>
    <dbReference type="GeneID" id="37163625"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="7">
        <location>
            <begin position="56"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH57013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="164" mass="18994" checksum="81FADC981ED7D3D4" modified="2022-01-19" version="1">MRELRIQKLVLNISVGESGDRLTRAAKVLEQLSGQTPVYSKARYTVRTFGIRRNEKISVHVTVRGPKAEEILERGLKVKEYELRKRNFSETGNFGFGISEHIDLGIKYDPGIGIYGMDFYCCMTRPGERVAKRRRCKARIGSQHRITQNETIKWFKNRFDGIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0L8</accession>
    <name>A0A8G1R0L8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myb-like DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_50731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514383.1">
        <property type="nucleotide sequence ID" value="XM_025664397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0L8"/>
    <dbReference type="GeneID" id="37167799"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018465">
        <property type="entry name" value="Scm3/HJURP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15992">
        <property type="entry name" value="HOLLIDAY JUNCTION RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15992:SF5">
        <property type="entry name" value="HOLLIDAY JUNCTION RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10384">
        <property type="entry name" value="Scm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="440"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="496"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="547" mass="60489" checksum="767050C7D26080F2" modified="2022-01-19" version="1">MERPAKRPRFSMGPEPEEEVDDMDIHEARAQNDLRLKSIFEGIFEKYGKDFTDVGDEIDLQTGNIIVNNGHIQAMEGEDDTGEQNGWLFETDLSAPPNPDAENVRLGSSAHSPDAEEIGGDAAGDDGGTQSQHPPTSMPWQTGLVPDQPWDAIMGEAANDDPDTNDERSSADSLLDTALCVQNNPDGSRGRKVTADATGKPTIKKANSAAEASAQSKEVKFSEAVEAIWRVPEISGDFSTPTWNKSRPASSFNTVRSQSPPGSGSIWALPWSSRRGSGQKRATKPQKSPQGRKHHSSPVVCDWSFAETPDGDESDDPLQEDYEPSPTPKRGVEIRGKRSESHTPSRAKDRCESCQQYFGRSDYISHLKGLLSQASDGQHDQAAMRKHLAAITNSHDSEKRAAATSTSAQKSGASSENITKVSAENTPDGPDTMTPTKKRVRTYISPDEARLIIEMRQVQGRKWNEIVERLPHKNLPQLLNWNKTHWSERRANPPPLSRPWTKQEREELIKIKDQHNLSWATVRARLSGRPVAEIEFELLQLWSGEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R140</accession>
    <name>A0A8G1R140_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_374717</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514514.1">
        <property type="nucleotide sequence ID" value="XM_025656140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R140"/>
    <dbReference type="GeneID" id="37159542"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000055">
        <property type="entry name" value="C6 transcription factor (Ctf1B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="687"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="738"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="874" mass="97422" checksum="0259C671962E24C5" modified="2022-01-19" version="1">MTNTAVSTTSPTPQSTVETEAKSKRKASTAGLPANARPVKRRASKACCCCRARKVRCDVVENGSPCTNCRLDQVECIVTESKRRKKSRVEVDNANPHQLSQSPAEIPDDGASLFRRLSECHGLSDMAPASPSQRSVDLDQGQHMPHLLYQSQANRIGSGDRYRRRMAPNPAVPATLPLHHVTSQIQQLLDPSFANTRSGGVVLPDYIRGLPPRLQKEDIDYLSMKGALTVPDVGLRNELLKSYIHYVHTYMPLLDLEDFLQTIVQNDGIRRMSLLLFQAVMFAGTAFIDLKHLHAAGYATRKAARKAFFQRARLLYDFDYEVDRISLVQSLLLMTYWYETPDDQKDTWHWMGVSLSLAHTIGLHRDPGNSRMDVRRQRMWKRIWWSTYTRDRLIALGMRRPMRVKDDDCDVPMLTLDDFEFHPFSPEIVSMVGNSEILQSVSHQRELALMFIEKAKLCLCVSHVLSAQYSVLSHKFGGTMETTMMLVPKKSAAETFEVRRCDQELEDWLAHLPTEIRYAPAAPSKLNEAQEVLHSHRALLKMVYLTTSSALHRPQVLPAIPFPSMDAELQEISRNKVRFAAIEITNIAQDLHSLDLTRYFPTTGVTVLLPAVIIHLLDIKSSDHNVRMTSLHRFYQCMRILQRLREIYASADFATSFLEAAIRKAGIQLTVAPQDVQARTNSIVDTSARVNTLTPPPDSLAQKIPDLTYPKSDGARRASQLPKESGPEFASTPPPSDGSENGSTSNINPSYHQDAFTIPNFDSELSISELMDLANDAEVTQNDFDALINFDDAGADFLAPDDGLNTGNGNGKNYGFGLGTMNNLSDIMGFDTEKQGVGLTGLGDGQLADDRAAASRNDMNTFAADLDAELGLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R170</accession>
    <name>A0A8G1R170_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_520770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514559.1">
        <property type="nucleotide sequence ID" value="XM_025665160.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37168562"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd17936">
        <property type="entry name" value="EEXXEc_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001660">
        <property type="entry name" value="NF-X1 finger and helicase protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000216">
        <property type="entry name" value="Type VII secretion ATPase EccA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000160">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050773">
        <property type="entry name" value="CbxX/CfxQ_RuBisCO_ESX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN / ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392:SF2">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN _ ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="475"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="1293"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="1571"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="1850"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1180"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2115"/>
            <end position="2152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="2198"/>
            <end position="2232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1180"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1208"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1238"/>
            <end position="1250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2264" mass="254012" checksum="21F3397BFF7A8EC9" modified="2022-01-19" version="1">MATRSDRLSKHLVLLEKGKRQVTKPGDAKLLLEALCGQDNHLRCIERVLASPALSDSLQNSFRLDLSPEFINNSVAPFLSYIQHPSIEDFGSGQFLRQMVSSIIEPPTFWNAFVRLHSQKKLNDQADRGFAWLLLKIISTQGCPSEIIATAQQISQARTFLVSSSLEVRTIGYRIDGILKTLRTRVDGKDDFRPGGRHDNDFECFRDISILPTPDEIASTKRPFYRRMDDIYQVSVDERSVAHYDNQFRLLREDMLAELRSDLQLARGQRKGRRSALTIYGLQLTGVSCGEEENRRRACSVQFKCTKGIPRLSHLPQAERKQLLSDTPNFLKHQTFGCLLDKMEIVGFASLDRESSDLTDDVPTVALSVSGDAALYRVLACAKMGLKFAFLVVNTPIFAYEPILLRLQSVIEYPLSNILLAPAPSPERLTLDEKLETIVERIRSSEGQSLHRIIHTTKSISLDKSQLQSLLDGLQQSISTIQGPPGTGKSFLGALIAKILHDETRKTLMIICYTNHALDQFLEDLLDIGIPPTSMVRLGSKSTPRTKELGLFEQSRGTSSVDSWSFVSQKREELGEAVKELQSYSAEYSRDSISKDDMLEYLEFSEDSTFFDAFTVPEEPTGMQRIGRRGKSVGKYYLWDAWRHGRDPGTLRDLISPQHAYIWTMAFSRRRELMETWQRNILFEKSTKLVELVRRCNVLSKNLDEYFYHKRHCAVLENKRIVACTTNAAARYAPALRVAKPDVVIVEEAGEILESHILTAMTMDTQQLVLIGDHKQLRPKINNYNLSVEKGDGLDLNRSLFERLISKGYPHSSLTTQHRMRPEISRLVRHLTYPDLQDSKRTCKRPPLRGFQTDVVFVNHCHLERELHEYAERRDPTLKASKQNPFEVEMTLKVVKYLGQQGYGTEDIVILTPYLGQLSLLRTELSKTNDPVLNDLDANDLIQAGLRLPGSTKVTRDPIRISTIDNYQGEERNIVIASLTRSNEAGDIGFMAAPERVNVLLSRARNALVMIGNASTFLASRKGQSTWKPLLEMLQAHGQLYDGVPLKCETHPDRMIVVQSPETFEKECPDGGCSDPCSTLLPCGLHSCIRRCHRALDHKRMKCTMTMHKACPKNHNYYWECSQGEPRVCRTCHGEAIEAERRRNEDAKLEEKRRKIQLEHAKQLAEIQYKIEMQRERLASEQKVRDHHETLAQKQKELESLTDAASRLTASRSGATKESADSTGNDNSEPKTVTLKSATRDEWNRQKTEEGQSNAALDTLMDMIGLENVKDSFLAIKAKVDVVVRQGASLSDERFGAALLGNPGTGKTTVARLYAQFLGSVGAIPGSFFIETSGSKLANAGIAGCQKHLNEIKSNGGGALFIDEAYQLTSGNNAGGSSVLDFLLAEVENLTGKVVFILAGYNKNMESFFAHNPGIPSRFPIELQFQDYSDEELRTILHHHMNKKYKGRMRVEDGPDGLYMRIVARRVGRGRGREGFGNARSVHNAFARITERQAKRLQRERRLKKPTDDLLLTKEDLLGPDPRTVLNKNATWDKLQALTGLRQVKQSVQALFDTVSFNYQRELEEKPMVEFSLNKVFVGNPGTGKTTVAKLYGKLLAEMGYLSNGEVVVKNPSDFIGNVIGGSEAATKGILASTLGKVLVIDEAYMLGGTSSSSNGGTTPDIYKTAVIDTLVAEVQSVPGDDRCVLLLGYRDAMERMFQTVNEGLSRRFPLSAAFDFENFTDDDLQDILNLKLKQLGFSATAEARSVVRQCLSRARNRPNFGNAGEVDILLDKAKLRHQQRLSARKTRNIDILEPLDFDPDFDREQNAVANCRKLFHGVVGCEQLVAQLEGYQNVARNMKRLGLDSREKIPFNFLFRGPPGSGKTSTARRMGQVFYDMGILGAPEVVECSSSDLVAQYVGQTGPKTERLLEKGLGRVLFIDEAYRLADGTFGKEAMDQLVDCLTKEKFFKRLIVILAGYDEDINRLMASNPGLTSRFSETVTFKNLSPSQCWVLLRDSLGQVHQVDHAVVRQPDGQFHARILASFEHLSTLPGWGNGRDVKTISDTIIRRVFSCPLDEGQTQMVITEEMVSAVLQSTVQERQLRATATVPNLPTSLAAMPAMAGPHHAAPSFTAASWAKQQDNPSTPPDTDSDAATPTEADLNGPRDPGVSNEVWDQLQADRKQHDAQIMHDAEIINEEKALRKKLDNNSEMPDDDERRQYEELIRSLVRQMFEIEERKKKEEEAQRKLREMGVCPMGYRWIPQATGYRCAGGSHFVSSAQLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1D9</accession>
    <name>A0A8G1R1D9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_55874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513932.1">
        <property type="nucleotide sequence ID" value="XM_025665484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1D9"/>
    <dbReference type="SMR" id="A0A8G1R1D9"/>
    <dbReference type="GeneID" id="37168886"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000086">
        <property type="entry name" value="Acetyltransferase, GNAT family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH56010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="174" mass="19610" checksum="3E67596AE7786F33" modified="2022-01-19" version="1">MSDQPTIRLATPEDVPIIHQFICELADYEKALHEVEATHESLLETLSFPDSPPKRGSVYTALITPPATAENPTPKPVGMALFFYNYSTWRAAPGIYLEDLYVQPSARGNGYGFKLLKYLAAKVLEIKGRRLEWSVLKWNEPSIKFYEQVGAKAMDEWTKMMMEGPALNKLAEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1E2</accession>
    <name>A0A8G1R1E2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-rRNA processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_490249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513072.1">
        <property type="nucleotide sequence ID" value="XM_025663651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1E2"/>
    <dbReference type="GeneID" id="37167053"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH55150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="185" mass="20691" checksum="70C70A2E472FAD7D" modified="2022-01-19" version="1">MTTQQPPQTATQYLDLGITLAINAWPALTLAVQSNWGGPTSSDKRDWLCGAISEMIQERPETDAEDLEDVLIQVMNDEFDVVVDDESAGMVAVQIMEMKGQTEKGEFGAIQEMWEKWQSKKGASGIEGFKRGEDQEDDDDSEEDEDEDMEMDDAPAPALVRAPREKVEPEVDEDGFMTVVSKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1M2</accession>
    <name>A0A8G1R1M2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_400399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514067.1">
        <property type="nucleotide sequence ID" value="XM_025657122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1M2"/>
    <dbReference type="GeneID" id="37160524"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="693" mass="77087" checksum="3FEA4AA8B225D63E" modified="2022-01-19" version="1">MAAVNRNMFEASVTTDRPQGAPLMILPLNLIAVIVSYVDDPGDLARLCRACRVLNYMALPQLYKHITLTSYDKIRYRDDEPEGMGSASPFSMGLNAIITRPYATLVRSLTLRGNWRELELEEHARVGRVPDSSMMLNIAVRAAVDRMTELESFSWELNTKMLETVYLGLAQLPKLTALTIRFPSSRHPRPTIVIPPMPHLRYLKVTDIDPLCYPDDISTLVFKCRKLRELNMHWSPRMRNAQEPSVMVHDYFRKCIAAKQPLSIKKIGLQNLYALHTEDFGLAVNGSTVEDVTILQHGGADLSMNTFVDSTWPTMPAHPIRIKSIRQDAVSKRHAQFLNQFTGLERLYFVNATHNPNDDINSPRPLTSAAALSPPSSDTSQPATNGTSTNCSAAATNSPGLQTSVRDVYLNNITLNHAATLRHLLLPARWPLSAPTVARLVHASPQLEQLGFATEFSDLEALGLLLPFLRNLKALRLLIPTCTSPSETARTGPLPKTFKYFSPSANALTAARTLSDIVEADDDTLIARLSESLADQQIFHRLKVIGLGRKGFQLGDYYTVPAEQAENQGHVQLQTPTGSRATSAEANIGYDKSPPAERPSPTANGHNAMVPSQRNGHVPPSVLGKRPREEDTPTTEPGEANHQADEQAPDPGMNACLPQVLLRDGRYWRRRVRRVGWEVLQHWEIWGLDKQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1M7</accession>
    <name>A0A8G1R1M7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_439383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514799.1">
        <property type="nucleotide sequence ID" value="XM_025658711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1M7"/>
    <dbReference type="GeneID" id="37162113"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="573" mass="64909" checksum="B7491801F9693E35" modified="2022-01-19" version="1">MSGNYDYPPASRRPSRGARTNERQQQQQQQQQQPPLNRLQHLRELLTSERNRGDLAFARAVETLNQEMDDYRSSRFWDRSSFEQARAALDQHMQQLQERTRQSRANTGSSGPPVRPRPGVPRLQPLSAPVAIPDESASDPPRSDSRTPRPRAGRGSDRPNRLRRPRDSNTSSLLDTPVPHLDSPTAMPQQVEDEHQLDRARTKRRKLDTDDNREGLQGFRYGQYGQVVPGALRMELTSCDGGRYEPHGESSWPENILRNDASVYCTKSDRCNLVLKHQGESPFCLKKIVIKAPKSCYNSPVREGMVFVSMSCDEVLARTAAFEVQWESTRPFARHLPGGMQPSQEYLNAYRPPLQSLGRGPVIDPSSDSESDSTDDPGAVEPSASNVPDPTSEFRVTTEYSAQSDVRHDRLDHMDDDDLISLTDTDSMPLGRMDEDNTICSDSEMSLSDDDSNVSTFTRRQRELSRRIRAMRRRYVAEREGQPRRRPYLAMPTPGLRPEGTLGSESPQLMKPHARFSIERNKSMVSIKFDPPPSGRYILVKLWSPHSGKNIDIQSIIAYGYAGTRFFPALSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R222</accession>
    <name>A0A8G1R222_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_282859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515674.1">
        <property type="nucleotide sequence ID" value="XM_025655214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R222"/>
    <dbReference type="GeneID" id="37158616"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000041">
        <property type="entry name" value="Alpha-xylosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1760:FF:000008">
        <property type="entry name" value="Alpha-xylosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000142">
        <property type="entry name" value="Alpha-xylosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051816">
        <property type="entry name" value="Glycosyl_Hydrolase_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863:SF2">
        <property type="entry name" value="MALTASE-GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034102313" evidence="3">
        <location>
            <begin position="19"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="4">
        <location>
            <begin position="261"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="5">
        <location>
            <begin position="628"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH57752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="736" mass="82287" checksum="5FA432A35F9DB9B1" modified="2022-01-19" version="1">MYFSSLLAIGALVQAAAATYLAPNSTGLRIQHGFETILIQPFGYDGFRVRAWPFRPPSGNEISFIYDPPIEGYEDTAHGMSYDTATTGTEPRTLRNGNIILRTTGWGGTTAGYRLSFYRVNDDGSETLLTNEYAPLKSLNPRYYYWPGPGAEFSAEFSFSATPDEQIYGTGTQQDHMINKKGSVIDLVNFNTHIPTPVFMSNKGYAFIWNMPAEGRMEFGSLRTRFTAASTTLVDYVIVAAQPGDYDTLQQRISALTGRAPTPPDFSLGYIQSKLRYENQTEVELLAQNFHDRDIPVSMIVIDYQSWAHQGDWALDPRLWPNVAQMSATVKNLTGAGMMASLWPSVADDSVNYAALQANGLLSATRDGPGTTDSWNGSYIRNYDSTNPSARKFLWSMLKKNYYDKGIKNFWIDQADGGALGEAYENNGQSTYIQSIPYTLPNVNYAAGTQLGVGKLYPWAHQQAIEEGFRNATDTKEGSACDHVSLSRSGYIGSQRFCSMIWSGDTTSVWDTLAVQVASGLSAAATGWGWWTVDAGGFEVDSTVWWSGNIDTPEFRELYVRWLAWTTFLPFMRTHGSRACYYQDAYTCANEPWSYGASNTPIIVSYIHLRYQLGAYLKSIFNQFHLTGRSIMRPLYMDFEKTDPKISQLVSSNSNYTTQQYMFGPRLLVSPVTLPNVTEWPVYLPQTGDNSTKPWTYWWTNETYAGGQVVKVPAPVQHIPVFHLGSREELLSGDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2Q0</accession>
    <name>A0A8G1R2Q0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_272335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516251.1">
        <property type="nucleotide sequence ID" value="XM_025655104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2Q0"/>
    <dbReference type="GeneID" id="37158506"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000024">
        <property type="entry name" value="Sulfate permease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="580"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="615"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="763"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="784"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="841" mass="92322" checksum="3B0C84BEA41A97FF" modified="2022-01-19" version="1">MSQNLMTKTGHGLAKVLGIKLPYRDPLGAHSDPVTRGESTFSYGTVETYSYLEPEPTTAEWLKEICPTWHDVLMYFYNLFPFLSWITKYNLQWFFGDLVAGVTVGAVVVPQGMAYAKLAELPVQYGLYSSFMGVLVYWFFATSKDITIGPVAVMSTLVGTIVLQAKQEIPDVPGHIVASCLAIICGAIVCALGLLRLGFIVDFIPLPAISAFMTGSALNIAAGQVKKLLGESADFSTRGSTYMIIINSLKYLPTAGIDAALGVTALAMLYIIRSVCNYGARKYPRQAKVWFFASTLRTVFVILFYTMISAAVNLHRKDNPMFDLLGSVPRGFQDAAVPVVNARIIKVFASQLPACVIVLLIEHIAISKSFGRVNNYTIEPSQELVGIGVTNLLGPFLGAYPATGSFSRTAIKSKAGVRTPLAGCITAIVVLLAIYALTAVFFYIPQAALSGVIIHAVGDLITPPNTVYQFWRVSPLDAIIFFIGVIVTVFTSIEDGIYCTICVSVAVLLFRVAKARGQFLGRVTIHSVVGDHLIQGDGKYGPGGLPDAPDNEGESRRSIFLPLNHTDGSNPEVEVEQPYPGIFIYRFSEGFNYPNANHYTDYLVQAIFRQTRRTNPFSYARPGDRPWNDPGSRKGKEESRSQRPILRSIILDFSSVNNVDVTSIQNLIDVRNQLDLYASPRTVQWHFAHINNRWTKRALAAAGFGYPTPASDDGFHRWKPIFSVAEIEGRASAAAHAEMVNNEHAHQNAVKRDLEEGLKHETHMTEREASGNDIEASSDNSSTPDDKLARDLKDSKAYRNRRKAAVVQGINRPFFHIDLTSALESALANSPPEEPIEEPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2Y4</accession>
    <name>A0A8G1R2Y4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_370007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516525.1">
        <property type="nucleotide sequence ID" value="XM_025655948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2Y4"/>
    <dbReference type="GeneID" id="37159350"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20339">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047545">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="338"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="655"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH58603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="709" mass="80317" checksum="1C589726B0B51519" modified="2022-01-19" version="1">MEGPNFTNPLYSALPIRMGYMDHANADLTLDDNPALLWDLYDHGFYPLPDYDQPMKKQRQISHGSSRSSDNSHESIINILDSDSDDNNRLGSGIKSGASLRPSTKSLSSSTMATTSAASRSNTHSEAVYIDLTLDDELLWQITDIFPGISHQHVEELIELHKKPQEHQPAPPLDSLKESVIEDILRHPSYPKQEKAKKRKIEDTDEEATIRYLRDIPERGSRAYLQLATNLLAQEFGWMPMKHIRDVLEEKKELFAAYLTLHSQENEQTGKYTKLKSKRFSNVPNLGKDDKTPIAENLARELGAAKKKAEKEDDALRKKKEKQEAEIKNEEEHSRAGNLIECQCCYLDVPANRSLPCEGDNVHLFCFACIRKSTETQIGLMRYQVQCVDTSGCQAKFSRARLQEAIGESLMEKLDRLQQQDEIQQAELEGLEACPFCEFKAIYPPVEEDREFVCKNPDCEIVSCRLCQQESHIPRTCAEANKEKNLPQRHLVEEAMSEALIRPCPKCKVKIVKDMGCNRMVCSKCRTAMCYVCRRDITRELYEHFERPPTYCPLHDNPALRSLQEIEKAQKDTIDSLLAQDPELKEEELRVHDAKDSAAKMSHVLQGHNNGLIRHLGQAPIHPNHVVYPGPAIPVGRANPPAVAHRVNAPFGNDNGWGGQGWLQNPLGQPRNPPGHPVPTNVVHRGANNRGNPLQDPARRVDTRPPWRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2Z5</accession>
    <name>A0A8G1R2Z5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HEAT repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_468957</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515489.1">
        <property type="nucleotide sequence ID" value="XM_025662303.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37165705"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001272">
        <property type="entry name" value="HEAT repeat protein (DRIM), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057525">
        <property type="entry name" value="UTP20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23099">
        <property type="entry name" value="UTP20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="871"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="3">
        <location>
            <begin position="1687"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 C-terminal" evidence="4">
        <location>
            <begin position="2508"/>
            <end position="2580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2418"/>
            <end position="2439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2546"/>
            <end position="2590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2423"/>
            <end position="2434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2546"/>
            <end position="2564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2565"/>
            <end position="2576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH57567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2590" mass="291485" checksum="E35F7407193305CB" modified="2022-01-19" version="1">MVAASSSSRAKPVKRVKGGTETTKSHRFEPFSQRVAKLKIDPIHRVRRPSFGEEADETSSYFRSAFEHWVELNLSDNFVHFVRKVNPLCESLAQILYHEDKIMSLLVEFIEKRDSLSMEPLLGLMAQFARDLGVRFEKHFATAVTLVASVAASHSDVEVVEWSFSCLAWIFKFLSRLLVPDLRQLLGIMTPYLGKERQKSFVARFAAESMSFLIRKAGLVYYKNATPLQRAVSFLLDDLRQAAEDGNNVEMYKEGLMAMFADAIKGVKYGIHSNGADILSCILDHISTGDDLRSSLGLDVASGVLINIIHCTTPDTFEPILDLIKTYIEKNCRKGEKQHANACCRLIFLCIATRKGTRVKNWKPVHQTLLLLLQNAAGAASAYAEATPQLLTAVAYALQVSPMDEMLPFMRSIMDAVSKDELSTHFLGFCATFSEWGPERFHSVVLPYFQKFVNNSWQDHEHDLCLALLRLNQAGCITSEVSKPGYITCPASWKSRVKDTFSKSDHNDTEVTLLSAYAKLPSALSLSAEPSLIPEVTSTLHRHLVRVLKQKNTDTSATTKLFLGQGFKTYVDLATTANELDKTLWDRISKVAAQYSRLPVFLHATLDYVSACNKDIDIKGSAVEEFAEVLISNLSGPSHKLRLLSLRILRELILASGEDAELVSLAIEIEESPLTLQSARVLAMHVRKLALAYPQVVSRRWMARLLPNFCFGLLSKKMAPLWDDAAAAMKSMCENPEGEKIVSDLAFQWLHERGSGDATTDAEEEDPESYVGGHYTCSNAAKIEDISSKYFENPESPATTLAEGFEKDHTFTGVIPASPRTQALRVLNAVPNIAEKKSRQVIPLFLSWALRDEEDVPTGGDSDTADSYIPWGFHDRLSFLALLGKFINPRVLYKAPEVHEALMGLLCHGNSEIQKSALKALFTWKSASITPYQENLLNILDESRFKDELSVFVRIGGDDNLIEEAHRVELVPVLLRLLYGRMISKAGASSGQAGQAGRRKAVLRTLSQLPDKEFEIFMQVSFGALGELDLVQDNQVNQQAFEQELVSPRRQTGLLKMIETVFETLQSRMVPYAEKSMQVVLYCLVRACREIEKDQAPAADSPEGRLLTVLRNIRHTCIRCLELIFSNTQDQDWSSYVRIIYEDVINPRLENFATETAQGVSGLLKLFHVWASAPKSSFYLVQYNDALLKKVVDCLGVDSARDEVRVFVMDEILVPLINLSTGKELQEQEKMSDIPADEIRSEVLSPYIEHTLSHLGRLLKRGPSRPLLISGVQTLSLLAPCVESSEETTSLISITTYLLRQPPDRVSPRTKSGLLKSLEHFLPLFNPQEDAKLSQEVFEAVSSMFDYFRDNANREVLARVFTAFAKRDEELVHVAALCEDLNSMSTKRLEVDYDRRLSAFREVNENLWEKLNAKQWRPLLYNMLYQVKDEEELSIRSSASFGLRRFMERAVLNDVEAFEPLVADILFPALQSGVRQKSELIRSEFITALGYFVKLNPERPNVQDMHVLLVGDDEEASFFNNVLHIQQHRRLRALRRLASEAAKGNIQASNISTIFIPLNEHFVFDEEADEATHNLIAEAVTTIGALAEWLDWNQFRAIFRRYRGYMQSKSDMEKNIIRLLGKMADALTNAMNQHTTIKAAAKDGMDGLETSSPVSTLARSIPSVAKVATELTTNFTPFLTDFIHHKNETQMSLRLPASVTTIKLLKLLPEDDMSIRLPPVLLDVCSILKSRTQETRDTARKTLNDIALLLGPSYFGYILKELRTTLTKGYQLHVLSFTVHSMLVATTDDFQQGDLDYCLPDLSAIVMDDTFGTVGQEKEAEEYVSKMKEVKSSKSFDSMELLAKNSTVLNLANLVRPLQSLLREKLTSNIVRKVDELLRRIGVGLLRNPGVESRDILVFCYEVVKETYSAPAQVKAQAPKSQQAENLEIDLRGSKRGEKKGTTSSYIHKLTRFSLDVLRAILSKFGSLLTPANLKGFIPVIGDSLVQAHEEVKISALRLLSAIIKLPIPELDSNSHVYFTEAVKVIKEAPSTNTEAAQASLKLVSAMLRERKSTKLRDGHLAYLLQRVTADIEEPDRQGVTFNFIRAVMARKFVVPEVYELMDSIATMMVTNQTRAARDLARGTYIHFLIEYPQAKNRWTKQLSFLAKNLDYKHQDGRQSVMEAIHMLLSKTGDELAQDIVSTFFLPVVMVMANDDAPECREMAGTLLGELYTRADREQMKAMLTPLHSWLEQTDNMLLTSTGLQAMRIYFEVEGTEKDKEARFVVDVLLAIMQPVLKAEETENWQALYFSLQLYTKLCKSVPAIALAKERTKLWAAIRECLFYPHAWVKTCAANLVGTWLADLAKNNAANGYGSIPLAGSMGLSLDKDAMLQLIRASLRSLRTPAVSEELAMQSVRNIIFLGRCCAQNGLEFAKTGNKELDSDASDSEDEAEDEAGRQTELLTTRAESLIPKTASIGLFASLCRHLEVEQIRGSLPVILLPLQHMTDTSIPAPRSSDEVFRETYKGLVSNCHEVLDILQKKLGTTEYVQIMAQVHDSIKERREDRRVKRRIEAVTEPERYEKDKRRRNDRKREKRKEKGAEHRSKRRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R326</accession>
    <name>A0A8G1R326_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin cortical patch SUR7/pH-response regulator PalI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_419843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515673.1">
        <property type="nucleotide sequence ID" value="XM_025657878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R326"/>
    <dbReference type="GeneID" id="37161280"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF7">
        <property type="entry name" value="SUR7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="30741" checksum="44C6A4A6D62087AE" modified="2022-01-19" version="1">MGCLQIFLPGIGSCVAFLLGILSLFAGSQRQFLPQADLLTLHTGGAGGQGAPDYFSIYTMSYCTGYQETYISDETTNATSTKKEIVDCSDRTVLFTFNPGEAIIKAMGTPSGSLSPDSWPSWITADFEALAPTNTAMVLLMVLGTTASAISIGIRIWTVVCARASENSRPPMYPGRPASSFDLDIPPSNIEFLAYLASLLTFAIASIIASVITTEFVKLINKSGSGYGVSATTGTSFMGMVWTAAVLQALTTANSLVAILRYRAQHCRCDWDESVSSESVEQEPLVGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4B3</accession>
    <name>A0A8G1R4B3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amine oxidase</fullName>
            <ecNumber evidence="9">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_418082</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="9">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="8">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8 9">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="9"/>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516935.1">
        <property type="nucleotide sequence ID" value="XM_025657799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4B3"/>
    <dbReference type="GeneID" id="37161201"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000002">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000018">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000028">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015328">
        <property type="entry name" value="DUF1965"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09248">
        <property type="entry name" value="DUF1965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0186">Copper</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="12">
        <location>
            <begin position="42"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1965" evidence="13">
        <location>
            <begin position="216"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="11">
        <location>
            <begin position="294"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="7">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="8">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH59013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="746" mass="84279" checksum="9BE57BC362DF406B" modified="2022-01-19" version="1">MHNMQARSATPLSARTRSNFTAFRSPSENPWKDLTDVETASVVQWLFQQPELNLTAANDAGEWDNTISLVELMRPNKSDVLQYLDHDQPPPTRYAHVVLDVRATLDPYYAEILVGPLPVTNQSATTWVPLEYPYTRKTQGRIRNLDADHDTIYSEWLYKISASIADITLDLFNGTALGLDNDTIRISGISPLWQHDGRIIRWDTFWNLPVDDFDASSILPLGLFFKSDVTGRDPSKWKLEGWFYNNIFYETTNAFRKAYYSPGFVKLPSNTEGDWARTDQQGPILPEDQKQPPVMVAPSGARYALDTDQKYVTWMGFSFYIGFSRDTGVSIFDVRYNGQRILYELGLQEALSHYAGNDPVQSSTAYLDSFYGFGPYTFELVKGYDCPIYATYLNTSFYESESTHTHIDSLCLFEYDADYPIQRHTTPSYVSTTKNIYLTLRSVSTIGNYDYTISYTFHLDGTIGIDVRASGYIQAAHSAHNTNYGYQIHSALSGSMHDHILNFKADLDILGTANSIELTSLVPITTSYPWSNPNQPRNTMHLSRRILSSETESRLNFISPNSQQTTMLSIINQDARNAYNESRGYRILPSSTSPPSSGHLTIINSSTLIHAAHWSEHDIQITQHHDHEPRSAHPYNNQDVYNPMINFNEFFDGGDLNQTDLVVWINLAMHHVPTTGDLPNTVMNTAVAGVRFVPGNYFTGDQSRGTVNMVRVGFGDDEDVVEVEAFGQAGERVEVVVRPVEEVLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4C3</accession>
    <name>A0A8G1R4C3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_467779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516950.1">
        <property type="nucleotide sequence ID" value="XM_025662214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4C3"/>
    <dbReference type="GeneID" id="37165616"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF537">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="36"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH59028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="349" mass="39239" checksum="3D8916CACC2D8E59" modified="2022-01-19" version="1">MKPSCPRFLRCHWRVTSSGFPNVYRPKFISAALSTAASAGLICQGEGGTRFRLVRPRGTPAHDKASNVWLAIDESRPDAEYISKLPPGDNNDSPWSNTALAAFKHELEMQRLFAKDPMIRRLADYVPESEPVGPMMVLEAFTDSLWDARNARPFTTKEIKWIMKGVLLGIYTVHMRGLVYTDLKMENVVLGGFDSSKPSENFRDLILKLADCGSISKPSTREITSLTYRSPEVHFGKSWTSSTDVWSWGIILAQLFQAQVDFRSAGIYDSIQKLAIDFDLSSLPFYAKDKQCARILPTPQPERAYMWANNMVEKGVPGNDIQFLVEVLHPDPNARLTVREILESGYLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4U4</accession>
    <name>A0A8G1R4U4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_279866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516618.1">
        <property type="nucleotide sequence ID" value="XM_025655183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4U4"/>
    <dbReference type="GeneID" id="37158585"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="155" mass="17625" checksum="43AA14843B1D12F0" modified="2022-01-19" version="1">MPLVSSMKGGWDHRPKRRTFPDVTPCTAILITRYDTMGYLRDINGTNTNQAIRQEQRSREIVCFSPLIWFIFAFDSSSSLLQSAGASVPANLPGPLWHLSHLPMTKAISPLNIKPTKRGKLPIYSHAYEYNIHLRVMVDQRKRGTHTRLLGASYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4Z3</accession>
    <name>A0A8G1R4Z3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_245420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517496.1">
        <property type="nucleotide sequence ID" value="XM_025654880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4Z3"/>
    <dbReference type="GeneID" id="37158282"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="108" mass="12352" checksum="615FD5B799CCEC60" modified="2022-01-19" version="1">MRSSRWAEAAPDYHHPPLRMTTWASVQDEPCTPERHRTSIPITSLTDATWTSPRDMDHDDGANRSILNADVQGRWVLGPSKKKKARSIQRRCGIWRNPDAGPRDYSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R588</accession>
    <name>A0A8G1R588_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_510697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517646.1">
        <property type="nucleotide sequence ID" value="XM_025664562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R588"/>
    <dbReference type="GeneID" id="37167964"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="617" mass="68978" checksum="6BCD50F12B87A494" modified="2022-01-19" version="1">MTSSHRCSFDSAEKPDSAKWIQVGDIPMAYARPNRIGSIVADNDTLQPSNRQLHDALTLSREYWYRLSRIACYVHGNGVNPELAHPHHMLCKVPSMHGGPHTTHALHIGASPSRTLCLQASVNWQLDESTVCDRAKDRTDTVLLYIGTKAAVPYTLIGKDFSFWIGLESEEVPGSNYLAVLTLGWCYVLSARLLEIYGRNSAMRYTDSKATAHYEAIPEPTMHTVDIGEVSDDTASWWLSSDGGEFLTPWSVIRPSAQSLAIKWRSKDSTKAQAPSLTPLSSKKTFEALSQFAILHDLGSHFSVAFTMALTIPTHNCHGSTLQLPQPSLDGAKCPATSINCVPQDWAALYDNLSYYITLSCNPETIISSLCGSFWEPGVPCNLVSPWLHPILSEVPEEEKLASSPGLYLELLAIMNDIRRPTIAALWLRAAAGGLTPMILRRTRRGRPPLDPVAFPWTGCPQSFMDIAGTGPYLDQSKGQIWRADAWRLLHLPTTEEDDLSYNYLTRTPWEPCGKMQTTECALRVVSHLNCPRHQIRYHHWNWEVENSAAIEDEGFSTTRAYMPTTRYSGHFVQEPHVFPEKPLDLEASEQASIDIFRWFIFNREGFPRGSSTKMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6H6</accession>
    <name>A0A8G1R6H6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_226423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518321.1">
        <property type="nucleotide sequence ID" value="XM_025654745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6H6"/>
    <dbReference type="GeneID" id="37158147"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH60399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="405" mass="46406" checksum="B4BEB611247B46BF" modified="2022-01-19" version="1">MHNNSTIKGRRSHRKSRSGCQQCKLRKVKCGEEKPTCGNCKRHGVHCSFALSTRMAESSLLSDQNSFSSQTSTPQSDYRPSNPSSPSGGASQPQMAAAPGPELAIADLELLHHYSTSTAYTFSLHPVIQTLWRIEVPQIAFKAPYTLRAILAVSALHLAVLRPEKQEQYISQASYHHEASLKLATPEIANITYDNCTPLFLFSALSSFICCAKPLKMGNFLLWEDHEIANWLMIIRGTGTIIDFAEESLKTGPLRTLFSVHRQRHDHSEISEPPTQHQFLEDFRRFVLHEAADNHEKQVYCDAIFHLGTCFTICFEKGWRLETSDVFRWLLRVPHDFLVFLKEYRPLSMVILGYFCVLIHQLEWIWCMKGCGTHILSQIYNQLREPVYRAWLQWPMEQIGFLPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6J3</accession>
    <name>A0A8G1R6J3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neutral amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_456669</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518938.1">
        <property type="nucleotide sequence ID" value="XM_025661463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6J3"/>
    <dbReference type="GeneID" id="37164865"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF20">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="65"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH61016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="494" mass="54572" checksum="8003BBB4A106EC51" modified="2022-01-19" version="1">MAESNTFKPVVSRRSSVSDNASAADKLKQMDLENQKQQVGSGSDTEGEIGRQIEMESENSIKYRTCSWQKTAALLFSEYICLAIMSFPWSYSVLGLVPGLILTVVIAMIVLYTSLVIWKFCLRHPHVRDVCDIGQMIFWDSKVVWYLTAVMFLLNNTFIQGLHCLVGAEYLNTISGHGACTIVFSLVTAIISLICSLPRTFSALSKVATLSAFTTFISVMLALIFSAIEDHPAGYTPEKGDPIVKAIPVPGTTFVSGMSAFLNISYTFIGQITLPSFIAEMKEPKDFWKSVTAVTIAEIIVFSLVGSIVYAYTGNQYITSPAFGSLGNEVYKKVSFSFMIPTLVFLGVLYASVSARFIFFRLFDGTRHKGNHTVLGWAAWTGILTILWILAFIIAEVIPFFSDLESIMSSLFDSFFGFIFWGTAYLRMRREDYGPNFYKNRGIRGWLGAILNVTLIIAGLLFLGPGTYASVESVIISYREGTVGTPFSCANTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6Y9</accession>
    <name>A0A8G1R6Y9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_191096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519163.1">
        <property type="nucleotide sequence ID" value="XM_025654431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6Y9"/>
    <dbReference type="GeneID" id="37157833"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="24010" checksum="196617774765038E" modified="2022-01-19" version="1">MAPKRSRDDTTTADEKRETTNDAPVKKRKGFSVGPANLPDGTYRRKTQKIKNDLIQKAKVKKAYAKVRAAELAAAPSRPIYTDDAQDQDEESKRADPAPASLELHPDRQAMLDQPAPEPEPTPAGRPQRGEKRNAKGRRERKPKPSAFAREMEIAEKRRKEAEKRREEREFRQKDREAMARAKRPDQAGKRRLGRESKVLLGRVERLVGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7P3</accession>
    <name>A0A8G1R7P3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_519060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517172.1">
        <property type="nucleotide sequence ID" value="XM_025665014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7P3"/>
    <dbReference type="GeneID" id="37168416"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="251" mass="27547" checksum="394A8EF64EB372CF" modified="2022-01-19" version="1">MSGVNKACCSIPPIVAQGYQGKGEYKTINGLKTYVTGPESATKAILVIYDIFGFFPQTIQGADILATASEQKYRVFIPDFFQGEPADITWFPPQTDDHKQKLGNFFQTKAAPPANLPKIPSIVSEANKLAAGGSFQSWSILGYCWGGKITTLASGQDNKLFKAAVQCHPAMLDPNDAKSVNIPMAVLASKDENPKDVEAFGANLQQANYVETFSTQIHGWMAARSNLEDEQVRKEYERGYRTALDFLQKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7S2</accession>
    <name>A0A8G1R7S2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenases/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_519089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517217.1">
        <property type="nucleotide sequence ID" value="XM_025665017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7S2"/>
    <dbReference type="GeneID" id="37168419"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="334" mass="36054" checksum="37DFEA7F8B129528" modified="2022-01-19" version="1">MPTLSQVRQSNTALGAQRQKMVAVFVGGTSGIGEATAKQMALAVKQPTIHLVGRNPASGSRVLEELRASNPNGSFHFIQSDVSLLRSVDKACAEITDKEKQIDLLFMSTGHLSLSKKETDEGLDDNHALRYYSRMRFVQNLMPLLSASPGPARVVSILAGGQEGTIEEDNFDLTKSWTFSKSNTYAATLNSLAIEHLATAHPTVSFLHVFPGIVRTPLMNATFGNFGGAILSFLSRPISITPEESGERNLFLSTSAAYPPATPKDPSHLGVPLVSGVDTAPASTGKIGGGSYILKYDGSNATREKLMADYRARSFPGKVWDHTLETFKRVLRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8J2</accession>
    <name>A0A8G1R8J2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phthalate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_369805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516657.1">
        <property type="nucleotide sequence ID" value="XM_025655937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8J2"/>
    <dbReference type="GeneID" id="37159339"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000409">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000511">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="45"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="482" mass="52870" checksum="E3A2AE4298CDDCF9" modified="2022-01-19" version="1">METEKSLEASHIEDAEKNSIQPGESLDYFTPKEKKRLTRRIDIRLVIPLGCLYCISLLDRTNLGAASVAGMQEELKMNAKNNGYSISSLVFFITYTVFQPPMTVIIRKLGPRLFLSAIVLMWGIVMIGFGLSPTWPVLAGLRVILGALEAGFYPGCVYLLSTWYPRFELQKRNALFYLIGSTASGFGGILAYGLMQMDGLGGKSGWRWIFIIEGILTCVMGIGSYAILVDFPEQSPKSWHFLNESEAAYVVATIENDRSDVYMEPFTLKSYLRSGADSKVWAYAAMYMLTTANSYSIAYFLPIILEDSMGFSVAKAQCLVAPPYVAAAIVMYTQAVYADRWHLRGPIIAANAAMGLLGLALLGYLKESGPRYFGVFLATIAANANCPALVSWQSNNVRGQWKRAFTSATLIGGGSIGGIIGTTVFRAQDAPNYRPGLLTTMIANALIIVVVAGLSVKFWRANKRVDRGGKPIEGLAGFKYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8L9</accession>
    <name>A0A8G1R8L9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arp2/3 complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_446464</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519230.1">
        <property type="nucleotide sequence ID" value="XM_025659509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8L9"/>
    <dbReference type="GeneID" id="37162911"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH61308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="388" mass="43687" checksum="6FECCAAAF00D1D27" modified="2022-01-19" version="1">MADMPIVLDGGTGFLKVGYAAQNFPEHQFPSIVGRPILRTEEQAGDIVVKDIMCGDEAAAARSMLQITYPMENGIVKRWDDMQHLWNYTFYEKMKIDPTGRKILLTEPPMNPLKNREQMAEVMLEGYNFGGVYVAIQAVLALYAQGLSSGVVVDSGDGVTHIIPVYESTVLNHHIRRLDVAGRDVTRNLIALLLRRGYALNRTADFETVRQIKEKLCYVSYDLELDKKLSEDTTVLVESYTLPDGRVIRVGSERFEAPECLFQPHLVDVDQPGIAELLFNTIQGADVDVRSSLYKAIVLSGGSSMYPGLPSRLEKELKQLWLTRVLQGNPERLNKFKVRIEDPPRRRHMVFLGGAVLANLIADKEDMWVTKQEWQEQGARALAKLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8U6</accession>
    <name>A0A8G1R8U6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Splicing factor 3B subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_417670</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517907.1">
        <property type="nucleotide sequence ID" value="XM_025657781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8U6"/>
    <dbReference type="GeneID" id="37161183"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000066">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000069">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000810">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="11">
        <location>
            <begin position="181"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="715"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="12">
        <location>
            <begin position="952"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="116"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH59985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1167" mass="129595" checksum="46DA93A10829CDA2" modified="2022-01-19" version="1">MSIAVNGEDEEMEDADGGHRLVGQYTATRSQIDEFAQGNGVEEEDVLLGREKAARIADRETDYQKRRFNRGPLTPTRADPFAANEHANVEGEGQTYREVMALRELEKEEERVQKLIAEKQARGEDDVQEHEATLKSEDKENAEAGSTVSVATGRKRKQRWDVSSEPTESAEAEAPQPADTKAKRSRWDQTPAPAVPGAAAEEAPKRRSRWDQAPAIAASTPVGNQGLATPMHPSQVGVPMMPTSFGTDISARNAPLSDEELDMMLPSEGYKILEPPPGYAPIRNPARKLMATPAPMASATGVGGFMMQEPESARAMGKQLPTEIPGVGDLQFFKPEDMAYFGKLMEGGDESAMSVEELKERKIMRLLLKVKNGTPPMRKTALRQLTDNARQFGAGPLFNQILPLLMEKSLEDQERHLLVKVIDRVLYKLDDLVRPYVHKILVVIEPLLIDQDYYARVEGREIISNLAKAAGLATMISTMRPDIDHVDEYVRNTTARAFAVVASALGIPALLPFLRAVCRSKKSWQARHTGVKIVQQIPILMGCAILPHLKGLVDCIADNLSDEQAKVRTVTALAVAALAEAANPYGIESFDEILNPLWTGARKQRGKGLAAFLKAVGYIIPLMDEEYANYYTSQIMEILLREFSSPDEEMKKVVLKVVSQCASTDGVTASYLKEHVLTDFFKSFWVRRMALDRRNYRQVVDTTVDLGQKVGVGEILERVVNNLKDESEPYRKMTVETVEKLIAALGAADISERLEERLIDGVLYAFQEQSIEDIVILNGFGTVVNALGTRCKPYLPQIVSTILWRLNNKSATVRQQAADLISRIAMVMKQCGEDALMGKLGIVLYEYLGEEYPEVLGSILGALRSIVTVVGINQMQPPIRDLLPRLTPILRNRHEKVQENTIDLVGRIADRGPESVNAREWMRICFELLDMLKAHKKGIRRAANNTFGFIAKAIGPQDVLATLLNNLRVQERQSRVCTAVAIGIVAETCAPFTVLPALMNEYRVPELNVQNGVLKAMSFLFEYIGEMAKDYVYAVTPLLEDALIDRDQVHRQTAASVVKHIALGVVGLGCEDAMVHLLNLVFPNIFETSPHVIDRVIEAIDAIRMAVGTGVVMNYVWAGLFHPARKVRTPYWRLYNDAYVQSADAMIPYYPGLEDDGLDRTELSIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9F5</accession>
    <name>A0A8G1R9F5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">La domain family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_390532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518834.1">
        <property type="nucleotide sequence ID" value="XM_025656775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9F5"/>
    <dbReference type="GeneID" id="37160177"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="580"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="675"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="718"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH60912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="748" mass="80196" checksum="A4D66F25A691ED70" modified="2022-01-19" version="1">MAASFSYAQAAKGIAPAQSPAKTSPEEQTQAGSKPEEQSVNSSSQTNADAVPSKAETAQETEVTHTIEKEVESTATKANTSEASSDGNSSTSSVPKDEDGTDTPNGTSESTWDNKSQASGTEKTNTGADSTKDKNAEKEKAVPAKELKAAPLPSVNIWQQRKEAQEAKAKAVAALKPASKGTSKTASAASSVSGDHQAESKPASKKKGSDVPSEGAKDRKKADGSKGRDDGASIPPVGDESLWPTPQVAQGEEKKKAQEKTEKSPVIRPHGKEKWMPVPYVPTAVFNTPLPSARRGGRAARGGRENSRNGTHGAGAGADKASGQAAQGSTAKQATSADRGRNEQNSGRANSLPAQSRRSNSADAGLPDARKHQAADRNRGPKGENANGAPAGRNANGADTFPRHHAKQFAKGHDAGHKGGEHGSRNPQLSVDAQAGPRQDRRFENGPKSADFASFHADRERKEKDFPRESRPERGRGGHRGGRGGHAGFNGAQNAHFPNNHMSHHNFMHPKFGFNDRQRSQQHGPVNGSGGHRMNIRSPSLPNSTAMYGVYPYPGDINTMYGYQPMHAGPMTAYPYAGQYYDPYSQIGMISMQVEYYFSVDNLCKDLFLRKHMDSQGYVGLAFIANFKRVKSLTEDFELLRHVARQLRSVEYVQAEDGLDRLRPRDKWEQWVLPMDQRDPSAQNDGPSPSSFVKPEDVYVDGAVNGQVPNGTADFNGAKTSLSSTAPEFSPAGTQNGQTEITNVRNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9G4</accession>
    <name>A0A8G1R9G4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_123071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519926.1">
        <property type="nucleotide sequence ID" value="XM_025653929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9G4"/>
    <dbReference type="GeneID" id="37157331"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21210">
        <property type="entry name" value="CH_SCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="602" mass="69035" checksum="1B617EDDB20CBFB2" modified="2022-01-19" version="1">MASVTSLDKDLRSLRLSRYTPQAAAEVRDWIEEVLHEKLPPGDLLDALKDGVALCRLVNLAVSPGVKYKQSSMPFVQMENISHFLRACQMQPISLPPHDVFLTVDLYEAKDPAQVLQCLTSFSRRANALQPSKFPRALGPQSKAATLSPHATGSSQGAYTPTKSSVSGHSSPARSPKPVSSWSKKSDEFVTAPAWNIHQYGYMGGANQGSMGVAFGARRQITTAAPRVPSLAEKEKRRKEEEERQVLEKQEAERQRQQEREAEEERARIEEERRWEEETNRLREQERRQVEEERKRWDAQQRKWEEEERQRLREEKETEDRLERERLQRREAQDSRLNGQFLSQYQASLPAASPVPPVSSENRERQRIRELERELERAKERERQYERERQDIQERATKSPPRSPRPAQPSYDLSSLEQERRMLRTEWQKHHDEPLTESDIPPSMPPRPLPEPVISAEDKPSTPPRPLPDPTGAKPPMPPRPLPDPTSYTPPSQSPYTQESRVDRFLASNRPPVAPKPAAHRPQDYTTTAEVDAENSRRAAAQEKTKAGGWASKSLLEREMERERERQREWEENQRQTQEAAARAGSSIAGAKRQIIGPRPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA23</accession>
    <name>A0A8G1RA23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_412671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519829.1">
        <property type="nucleotide sequence ID" value="XM_025657577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA23"/>
    <dbReference type="GeneID" id="37160979"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="495" mass="54688" checksum="B1433679E6F55C07" modified="2022-01-19" version="1">MVLTIDLGEDRLSSLNSTIDLNIHASAQVLIPEDTGLTDAACIERLLKSQDLWVFQTPELKLYISVNIDASIVLSASTFASSVGEMMCSSKVFSWSASESYSHLHYGDVTSFKLIIGIQRDLSQSKTRPTRKTTLFDYLDHIHPPDYIKTVFLSTVNASMTFTSKNETAQLYILNADSLANPDSVGDYCYMNYIIKNTQDTISFGPQPDLYTNNSDNTQTTSFIDELEGLLKSEQSSPLPIPTEESFEKISPNGQREQLNNLFTIGLEALLFGRTAPSNQSDLQSKKRQPLSQLAPSVFNPNYHREMSQRSTLIPSITKSLSSILKLPNHQSLQSKLGKLNNGNTLHPTGANIDTNSIRNTISASLFRIAQKQLYKPQASRKLRFQAPPPNPQCEDQPSPVEERMYGEPGYSSDGEEELLGFSEPDESSSCAMLSTTTAAAPSSSCGSLPFSQDDIMSNGFSEDDIIPTLFSDDMVEFEGFGDDHDDDDMLCSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA65</accession>
    <name>A0A8G1RA65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_364651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519224.1">
        <property type="nucleotide sequence ID" value="XM_025655705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA65"/>
    <dbReference type="GeneID" id="37159107"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="111"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="355" mass="39930" checksum="7D303CF9F4B37136" modified="2022-01-19" version="1">MLSWNQPLTIWQKVQEAWNSLIVIKTFLSVSVTAAFRGKNGAKQYNVHVLNAVTRKLCVTFTPRQLQLRDTPTEEVYRQFMASRGLQPQTVPLNHGAKGHWIGNKNAKNVLVYYHGGGFFLFGRPQHYQLLAHMLDRLNEAGHDNLAIFFLTYTTTPHAVYPVQLRQSVEALRYILTETGRSPANIFLGGDSAGGNLSLAVLLHLTHPHPEIEPLKISQPLAGVFGCAPWVSYKLDGPSVQENAYKDALSEEILDRWSDQYLSGKEGDPWSEPARAPMDWWEEIQAKDILMTAGRDEILLSSIDEFVERFKKVVPNTVYVVAQDETHDSAVYAADVVGYDTQQTQAIVNWLGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAC5</accession>
    <name>A0A8G1RAC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Succinate dehydrogenase C subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_444325</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome b560 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520918.1">
        <property type="nucleotide sequence ID" value="XM_025658992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAC5"/>
    <dbReference type="GeneID" id="37162394"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000008">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01000">
        <property type="entry name" value="SDH_CYT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH62996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="188" mass="20110" checksum="FDB61232DC96E052" modified="2022-01-19" version="1">MLSQKVAQQSLRRLAVQQPYALRWSLMNSVSPAAVALGRAVQTRHAATSSNSSDPTKLLAQQRLNRPVSPHLSIYRPQITWIGSSIHRITGIALSGSLYLYASAYLASPMLGWDLGSASAAAAFAALPVVAKVALKTTMALPFTYHCMNGVRHLIWDTGAGLTNPQVIKSGWTVVGLSTLSALILAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAG1</accession>
    <name>A0A8G1RAG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_409664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520515.1">
        <property type="nucleotide sequence ID" value="XM_025657443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAG1"/>
    <dbReference type="GeneID" id="37160845"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="570" mass="62538" checksum="A1B9390357F8AF08" modified="2022-01-19" version="1">MTPSLILALVASFFTVPLVALHSLLAWQYNKVVGFASQKALLNAACTYILRLTILIWIAASAAGLVLVSQQVYCLADDGGGDFWKIGISCALQRASVIVSIISFVTVCLFFCSRELCERPYDISLLGVYKPQLSTCDDKMSASSTMGSHVSLENDIYHVCRRPDVTFGRDLYLSSSSNSICKAGSIDHPASIHEKPQLKLDTKCESEGSGIYSGTTLSVDGTPSKNSSRDGTNSDVSSNASVTPPKATLRAPYDPYRQAVLAELPGSPNFRHRRHQPYGSPFRLLPKVFASQISLSSDPEILALAGPDAVADVEQPAEEHSTDNIEPPPTPKREYAPGHPLASSPVELPFPSSPPVERSLFSMTTSNPELKTSRSEGSTLPRSISSSSADAPEVVAPEPLRVQRSNTSHTAPITSQYNFSRPKPPVVPPIPPRQPNHSYHGSLSQHGRSRRQNSIRSSGRRSQVYRFEACQIPRHTQSQYYPQQSRYARRSYFDTHRRMPSRRRRNDVEIVYSSTRRPRSNTCGGFGTTSSLDCIRESGASVDEPEDIFADGNTYRGTTRTTSAHGMYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB01</accession>
    <name>A0A8G1RB01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_254643</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the taffazin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517872.1">
        <property type="nucleotide sequence ID" value="XM_025654963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB01"/>
    <dbReference type="GeneID" id="37158365"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="14">
        <location>
            <begin position="69"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH59950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="385" mass="43842" checksum="30CFC90E86ADC9A6" modified="2022-01-19" version="1">MSRSTDSGGATADAPSLPWRALSSTTIFGVAALCRSFLYFCSRPQANGLDQFLELLDSRSDPSQRTRGLLTVSNHTSVMDDPIMWGFLPMRYNFGLANWNKRWGFGSHDICYQTRPLALFFTMGQVLPTHRSAHSQYGGLAQPVVTQAIRLLSKGPFPADPHLAVPERQSWSLQNVCVDPFSDLPTAYTTDGHDSHLSPSSYACNSYSWFHIFPEGKIHQAPNKTMRYFKWGVARLILEASECPDVVPIWLEGFDQVMHESREFPRFLPRVGKEVSVTFGQKVDREAVFGEYRRRWQKIKAKAERIAPETRDLPFGVLNDQLLYDPEAVELRKEVTKKVRDLVLDVRRTRGLSDEDPKEGLVETWIQEGPKREGKMDDDSWVRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB37</accession>
    <name>A0A8G1RB37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_121004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519843.1">
        <property type="nucleotide sequence ID" value="XM_025653911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB37"/>
    <dbReference type="GeneID" id="37157313"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039712">
        <property type="entry name" value="Meu6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039483">
        <property type="entry name" value="Meu6_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073:SF1">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15406">
        <property type="entry name" value="PH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="80"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="536" mass="56264" checksum="6F0C107539001E58" modified="2022-01-19" version="1">MSDVQKPVEETPAAAPAVAPATEAPAATETPATETPAAEEPKETPAETTEAAAPAAAEESKTEETPAEQPKEEPKQEEVTPASEGVLGYKAPGLVKGLRFAKRFFYFSDDAVESKQLSAFHQNEKAAVANPIAAWASQTGKGLLFFTKRAEDKASPAGIFNLADVSDIAKEGSTELHFKVNGQKHTFQASSTSERDSWIAALEAKAAEAKAEKEAVTSSEGYKAELEKLSKPAVAEPAKKAEPKEEAAPAEDKKEDKAASKSRSQSRKRASIFGTLLGKKEEAKEEAAPAEDKEDKAEEAKPAEAATEAPAAEASAAAETTEAAPAEASDKKEEKEEKKEEKEEKKAETPAPKSKRASLFGNFFQKVTSPSHEKSEKEATAPAETAVASTAPQLDNPVEEAAVKPIEPESVTAPAEAEAAKDAAPASPAAETPKDKRRTSFFGNFGKKKGDSDNEGADGEPKPKGNKLGGIFRKPSKAVKSEPKEAKEATEAEAAPKEAPVQESPAEESAKPAEAAPAEESKPVDVATSTPVQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBH7</accession>
    <name>A0A8G1RBH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_364412</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519302.1">
        <property type="nucleotide sequence ID" value="XM_025655698.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37159100"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF9">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034195435" evidence="4">
        <location>
            <begin position="34"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="843"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="886"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="915"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="941"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="974"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1027"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1135"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1179"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1226"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1257"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1332"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="842"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="536"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="600"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="705"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="804"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH61380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1369" mass="151284" checksum="E68D8B2810CFD847" modified="2022-01-19" version="1">MVAFTHIAGGSAPSSIVACVALLLFACLHTVVAEIDSVFKSRPDLYPPVLTLEHRVPDKLSPGYIFVGPYEASNSGPYIYDDEGSGAAGGKDHLCFFQGVQQNGYCRGHGVIMDDHYRIVRTVVPGGGMASSDMHEFMPINDGKTALMTVYQQRQFDMSPWNVKSGMGWVMESIFQEVDVETNEVLFEWKSLDHVDPSDAYTWPSHTDTSGTGLDPRSPWDYFHINSIDKNADGDYLISSRHTCAIYKISGKDGSIIWRLHGAHPTFKNINFSFSQQHDARWLGENSTHTLLSLYNNGFNGFNRTHDFSSGMIILIDHQDNTATQLHDYSPPGKTMISSSQGNMQVLPNKNVFIGWGNNAYVSEHDEEGNVLLWGYIDKDRIMNYRAQKFEWDGMPTDVPALWTYSQSTDTFSPTTFYVSWNGATRVKYWRFYGATNSTGPYMLIKQTEKRGFETSYSAPHFYRWTYAEAVDVEGKVLGKSRSMFTFTPSPDLQGYCGRESCENAQTYGMPGEEGAGPAIPPAGINTVPWVDPDHPNAHFDWGQTGDDEDEDESGKNNPADYRNLDNNVGWIAPVFGFVVAIVAIYTIMRIYRRQQQFSRVKERASTESVDRIERSKPWTESEETPWWHWRRWTNPGPAPPFLLVLLQYRGLPYHHSPPPPKGNSPMPAPKSGSQGTAGRPSLPSLSLSSTTPSSAISTPAATPNPLSATSSSFAQASKSRNARHTRATSWTSGHDQGGEPDPADFTSSQQRRRRESNISLADVSEGSSGRYDDDYDDNRSHTNMAVRNTSFDWGPGHARSRSHSYSQPQMSLLQPQELADSSAPRPRPAPVTWMSLPRKGQLALLGLCRVFDFLQIASLQAYMFYQLKSFDENLSDADVSTQAGILQGAFTAAQFATAIPWGRVADAEWGGRKFVLLVGLIGTALSCLGVAFSTSFAQAVFWRSFGGAINGTVGIIRTMIAENVKEKKYHSRAFLILPIGFNVAALFGPVMGGMLADPVKAYPRLFGPDSSFGGADGVQWLVRYPYALPMLANCIFLTFAAVCVAIGLEETLEACKGKPGLGVFSMRIFARGIRAVVPSNSPLYQRLPFADYDEAGPLLNRRDPAESYEMEEKATKASRQARTLPFRRIWTKNVLCTLLAQAFFDFQMGAFNNLWLLFLSTPRYDANDPASPVQRLPFIFTGGLGMLPQSVGFATAILGVIGMLLQFTIYPSINNRLGTAKSYQYFLTLFPLAYAFAPYIALAPSSAPPPGQANGGWVWFSIIVVLFLQVTARTFTLPTSIILLNNCSPHPSVLGTIHGIGQSVSSAFRTIGPIFSGSWYGYGLEMGMVGFAWWLIALVSVFGCVAAIFVYEGSGHEVFLPGEEEERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCF5</accession>
    <name>A0A8G1RCF5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_433834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521225.1">
        <property type="nucleotide sequence ID" value="XM_025658436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCF5"/>
    <dbReference type="GeneID" id="37161838"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="170" mass="18580" checksum="4F4CB24391FA76EF" modified="2022-01-19" version="1">MAGFKDVFIDMERLRLNSISHATSFTVSPVMKNITQTTSTCFMPLNSYVLLTPTSMVPLVGEQYIYGQWVGAASDECFNLTGTCDEWMTPDPANGDVIVFFAHDKLIPNNKGLPHIIILENGKAELDATEEVLFAASPLSIGLLKEQPESTEILSDTASMGFQKSQSVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCG0</accession>
    <name>A0A8G1RCG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HLH DNA binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_412633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519812.1">
        <property type="nucleotide sequence ID" value="XM_025657574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCG0"/>
    <dbReference type="GeneID" id="37160976"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="236"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="379" mass="43033" checksum="43E0B330414CCB1B" modified="2022-01-19" version="1">MMFEDMNTMADDISRRCSLPASSTADMSEDRRLPPLPRVEPLPRGPFDPFTTNIGATSSPSSQDAFPVRSPWPEAEHIVTPPSPATSADSSWPESVQSQKTFDWPQELSPAELLNLIAPKHINRKPPLQQLCGRKRKESMVSADSDDQREKHRIAEGNRRKNLSQLHRELDSRIHDFFLERAGWNPSKSLPESKEHIVQAAIFLIDFMLLIIIHLIRQENEMPRQLSEKLEPQIRCMQLQQLVSSLQQQNQTAQQQIKSLKQENQMLEERNQALELQLKSYEHMFRSPKSEPLTSQPIIHHAEAKPRNMLPGLRVFCDEIAASSPESSRLESHPTAPAFTFGHTYLTHTPSITRSSSPVFAHGPHSVPVSRRQSIIPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCI8</accession>
    <name>A0A8G1RCI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pumilio-family RNA binding repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_359554</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520469.1">
        <property type="nucleotide sequence ID" value="XM_025655516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCI8"/>
    <dbReference type="GeneID" id="37158918"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF48">
        <property type="entry name" value="MEIOTIC COILED-COIL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PUM-HD" evidence="7">
        <location>
            <begin position="460"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="523"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="559"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="751"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="365"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH62547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="801" mass="89024" checksum="C369F2FC5FD0A5D8" modified="2022-01-19" version="1">MSSHSDAPLNLERRQCEEGIIDSGTSATTHAVYVERESSGLKHLNVSTSPSDCTVSSKGGDCQISGADKHDIPSNKKQKLEHSSNFTFCGHSEMERLLAKLSPKPQSTTPKYPVDQDFIAALPDKQDLLRTSNHTITNHRILSGDESGLIKASSIQRPRDVSHSFDVGKADNVSVDMCEVLRLKQELLVANSKIALQEQELAQTRVIKHTLDQALGPPSETDFNGDITEQTISNLQSALYSSNPAYSQFQDGWNAQDDSQSEMSDALSAGAYNRSRGYWNTPTQQVCSTALSAPIIERSYGEPISLPSANSLGGDSNRFWGNSGTNTSVTGHDALRSHRVFSGPSSGGYTLDTKLPEEQVRFLEGPGLGPRRSITQASRNGPFFQPQSSAWSAFTPGSSDSHGPRSPVNRSNSTYQHVGLFPITQYHQRPVGTPLSPTATEFTASNPSATQWSTSVAGGNTHQTYISPLEPINYRRLLDRNVSCDWKYIVDKIVCNNDQQASIFLQQKLKVGTTEQKYDIIEAIVHQAYPLTVNRFGNFLVQRCFEHGTPEQVVSIANAIKGNTLSLSMDPFGCHVIQKAFDCVPEEHKAIMVHELLRRIPETVIHRYACHVWQKLFELRWSGEPPQIMTKVNEALRGMWHEVALGETGSLVVQNIFENCVEDEKRPAIEEVLAKIDVLAHGQFGNWCIQHICEHGAPQDKSRAIEHIILWSVDYSMDQFASKIVEKCLKIGGTEFLDRYLARVCTGRTDRPRMPLIDIAGDQYGNYLIQWILMNAAPHQRELVASHIRYRLSPHYDIAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD65</accession>
    <name>A0A8G1RD65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">General transcription and DNA repair factor IIH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_359602</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GTF2H2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520471.1">
        <property type="nucleotide sequence ID" value="XM_025655519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD65"/>
    <dbReference type="GeneID" id="37158921"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01453">
        <property type="entry name" value="vWA_transcription_factor_IIH_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000477">
        <property type="entry name" value="General transcription and DNA repair factor IIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="15">
        <location>
            <begin position="93"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH62549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="457" mass="50248" checksum="67FE9E18866B437F" modified="2022-01-19" version="1">MVDSDEEYTGEISEDEDESNILSGSRGDTAGASRSKRRKHRGGAEWEVSRTWETLVEGADGTISSTVEGLLEAGKRKRLLRDTTPLQRGIIRHLILIIDLSQSMTEKDLRPTRYLLSLRYAQEFVREFFEQNPISQLGVLGLKDGLAVRVSDMSGNPTEHISAIQSLRDQDPKGLPSLQNGFEMARGALFHTPSHGTREIFVIFGSLLSSDPGDIHQTITTLINDKIRVGIVGLAAQVAICREICGKTNGGDDTTYGVALNEQHFRDLVMSVTTPPATYSQKQSTSSLLMMGFPSRTVEAYPSLCACHSKPSRGGYLCSRCNSKVCGLPAECPSCGLTLILSTHLARSYHHLFPLMNWVEVSWQHASRSSVCFACGISFPPVPPKEQWHISEGQAKGMSVSSRYECTVCKNHFCIDCDLFAHEVVHNCPGCQSKVIIPTSSEPSQNHEALDRMDTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDG0</accession>
    <name>A0A8G1RDG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell wall biogenesis protein Mhp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_484992</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519177.1">
        <property type="nucleotide sequence ID" value="XM_025663285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDG0"/>
    <dbReference type="GeneID" id="37166687"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="914"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1171"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="930"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH61255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1198" mass="131324" checksum="9CB69A06892EBDD3" modified="2022-01-19" version="1">MEGIETVDVSWLHHSQKDHLSRCKSASSVVSDKSVADSDVTYAQERSLEKPSTTDNNSSASAPLTPTISKGSSQEDDAKATKEVKNEDKSVEGRPTGTSPATPKTAPRPVTGRRNSWISTLSSKFSSGSTPPSQSNMKAQQSPKATSPVSKMDMHNPFGAAYSPKDKEEERTNENSPFASTSPKGPSFLQSAFRKLSSSASGGTGKAASTGTICQRRVMNIDPDRDRCKIPDLNPAQLRRVAFCVDVEIAGISYRESDEDSPPASSRRRPVPEVNNQKSKRSHIKSKEKEEAAALKNPQAVVSSKDKGSPTNGADGKSSGSPDTPPAEANANGETKEPTRKQEKKKRSEEERRERRERRRRQAEANGSIPMQLTADGQEYGCRTPASNTSRTKTQSHPTTDPVRIYRRCCQLRETPVLKRIVDEISSPSSTLAESPGTVAVLDLSDFPMTAEDIATFCDWLAVVPVRKLIIERCALTDDSVRSILAALLSTRTVEQMMQRRRKGKKAEVVSSEKEQRFSVVEKVSLKDNSKIGPEGWRHICLFVHLSKSLKAIDLSGIPLPKTPITVNCSNKGASQTQNVTNVATLFANSLAQRFGGDHLEELLLSECRPTTEDVKKICDAATTLGLRRLGFANNELSREGLEHIVDYLKAGKCEGLDLGGNPIQDQLDLIISSFTEDHPLYALSLADCSLTPSTVYPLFQGLTRLPDLRFVDFSHNPGLFTMQPDALATFRRFLPKMPALKRIHLADVNLSPDQTIALAEVLPECPSLCHLNILENPAITALASATDPANQEEACAVYASLMAAVRVSRTIIAVEIEVPTAENNEVVKALASQIVAYSLKNLEQGAIAAEFSDPTDTSTRSAVHVPEILQHIVGHGTGDEVEEIDEAAPDEDYVIGGTGVVKALGVCLGNVDRHMPGDQSGPPSGTTTPRHRKSRSYVTKRPRDMSKNLLESARNIRTRIQSALVREDKAGNDTNYRRLQFLDFTLQRMIQRFEDEYPETRIIPQSIPSYAIQDTSSQGSNDDGWNGPVSENTQLNGTCADAEAVADEEEEQYAVRLSRSSSITSLHSRAMTSEEGHVHRLGQNIRRDFLRPSFDQADDDMSAFSFEESHMAALRDKLDRLQEEQTHAPFESVDADKALGDLGTTVEELWAARKNDAETFEKFRQSQIAAQFNSGKRTSSSRSNGNDDTESDQQASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDG1</accession>
    <name>A0A8G1RDG1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Cytochrome c oxidase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Cytochrome c oxidase polypeptide VIIA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_483485</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the fungal cytochrome c oxidase subunit 7a family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521584.1">
        <property type="nucleotide sequence ID" value="XM_025663162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDG1"/>
    <dbReference type="GeneID" id="37166564"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22888">
        <property type="entry name" value="CcO_VIIa_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014368">
        <property type="entry name" value="Cyt_c_oxidase_su7a_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000283">
        <property type="entry name" value="COX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH63662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="61" mass="7016" checksum="94CF52E4B16973A9" modified="2022-01-19" version="1">MASVAPITGMLRRTLVLDLSTAFGFGTTFGYLWWYGFHLPRVRARDDYYTRLEAERAAAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDQ8</accession>
    <name>A0A8G1RDQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_433172</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520472.1">
        <property type="nucleotide sequence ID" value="XM_025658411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDQ8"/>
    <dbReference type="GeneID" id="37161813"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF171">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="14"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="251"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="563"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH62550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="917" mass="103255" checksum="42B0D25AB53C9839" modified="2022-01-19" version="1">MASKDRDILPDVVKPVHYNVSLFDLQFGGSWSYKGIVKIDSKVTRPTKSIVLNSKEIEVQDAEVFGKDGTKLAKASNIAYDTKSERVTFTFAEEIHPADVVLSISFTGIMNNAMAGFSRSKYKPVVDPTEDTPKEGDSYYMLSTQFESCDARRAFPCFDEPNLKATFDFEIEVPRGQTALSNMPIKSERSGSRPELKMVSFETTPVMSTYLLAWAVGDFEYVEAMTQRKYQGKSIPVRVYTTKGLKEQARFALECAHRTVDYFSEIFEIEYPLPKADLLAVHEFAMGAMENWGLVTYRTTAVLFDEGKSDTRYKNRIAYVVAHELAHQWFGNLVTMDWWNELWLNEGFATWVGWLAVDHFYPGIQWTRALTDQMQLTIFSRTEWNIWSQFVAESVQQAFQLDSLRASHPIEVPVRNALEVDQIFDHISYLKGSSVIRMLSDHLGRETFLRGVATYLKAHAYGNATTNDLWSALSEASNQDVTSFMDPWIRKIGFPVVTVTEQAGQLNVRQNRFLSTGDVKPEEDETAWWIPLGVKSGPKMADVKPGALVSKEATIGELGKDSFYKLNKDLSGFYRTNYPADRLAKLAQSLDLLSTEDKIGLIGDAAALAVSGDGSTAALLALLEGFKGEKNYLFGNSYTSCLVLNDFHRVWSQISSTVANLRSVFALNESVAAGLKRFALELSSPAANEIGWEFSSEDDYLTVQLRKLLIGMAGRAGHKDIIPEAKRRFELWKTGNDKNAVHTNLRSVIFSIVISEGGREEYNAVKQEYLKTDSVDGKEICLGALGRTKDAELVKDYMDFVFSDKVAIQDIHNGATSMATNPLTRHLLWDYMKENWSAVETRLSANNVVFERFVRMGLSKFADHDIAADIASFFREKDTGAYDRALVIVADSIRTNARYKERDEKQVLEWLQAHGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VH64</accession>
    <name>A0A8G1VH64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UbiE/COQ5 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_453472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510998.1">
        <property type="nucleotide sequence ID" value="XM_025661062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VH64"/>
    <dbReference type="GeneID" id="37164464"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="266" mass="29510" checksum="617B5D002C5B2CCE" modified="2022-01-19" version="1">MTTYTTDHAPAVLQTHGWRTLSNSVPYILPYLKPNMTILDIGCGPGSITIDFARHVPSGHVTGVEYVPDPLEQARTLASSQGITNITFQVADIHALPFPDNTFDLVHVHQVLQHIADPVLALREMRRVAKPDGGIIAARESSAMTWYPENKGIELWLDMTTKMAREKGGNPHPGSRIHVWAEEAGFVQERIKKTAGSWCFSSPEERRYWGGSMAGRAANSGFATQALEGGFASKEQLEAVVRGWEEFVECERAWFGLLHGEIVCWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VH72</accession>
    <name>A0A8G1VH72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamic acid-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_202272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825085">
        <property type="protein sequence ID" value="RAH52325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510247.1">
        <property type="nucleotide sequence ID" value="XM_025654549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VH72"/>
    <dbReference type="GeneID" id="37157951"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018822">
        <property type="entry name" value="UPF0646"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10336">
        <property type="entry name" value="DUF2420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="873" mass="95937" checksum="7EDE44157E7FF2E8" modified="2022-01-19" version="1">MTTASSLAPTNMEISVADDKMEMASPYQGHVDDFDIDIDIMEDQASVTDKDMMVADEYFEYDHDGAPDEDMVDDVAEPTMVDADEPYTGADYTVEMQDENERIYEAEMLEDDYEEDNDTPVAEAQDEVPTSSEAQNQAVEGAQVPEESAVMPVDKHSAEHELQEEPQTEQQTQADAQNDHSQGVEQSIDQPEEHAPQQPEIDTAESTEIKKPLEGTNTVEQESHNVAEQDDREETANNADQPRVLESGPSDVEPPADAYKDPAEKLEGTVEEEHEGQGQEGEGDEGKVEAEGQGGEEGHGEEETKVTETQDRSAQAQDVEHLVEQEAPATERTPLHPVKVYYQDNEISLFPPREGDSSETFFLEDESLAFGSFGKLLGSCREVLREHIGDSEVLVVDVEALNIQLTEDSLHIDKVTLHQIVDLYLRLCHNDGVEEPEALYLSLSTRPTVAAELSSLSIAANEGKGLSEVYWDGYGEAEAASAEVYEENQEVDIPDDLQQESSEAEDAHSDSEDNYEPDVDSTLQTGAAEQQQEGHGDQAHEDHDQAASDNDDAVGPASSDVREGDNDQDSNRHEAHQAEPESVESVDQYELNESYESEEQSESTATVTQQPLPDSADGLADHDHDHDHDEHETEHYGTGVADEEAYPEEETNVDATEHYDYQEDAEAAEAADLPGEADEEFDGDATAPDVQAPDDFQDIHDSDEVQDGTVDADFHGLENDDGEVHRSGPGEEASNQTETVPDSVSQEAPEITNKSAEDLEDDSLGTAEDLLKSPRKEDNRHAAEDTNADELEEPGEIHDESEEAPATHDDADELTFDDEDYLDLGVQDGLAAGDEADLAKSPSRGPTKRHREAEDEFEFTETPSPDAKRSRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VI36</accession>
    <name>A0A8G1VI36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_380551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511883.1">
        <property type="nucleotide sequence ID" value="XM_025656390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VI36"/>
    <dbReference type="GeneID" id="37159792"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="153" mass="17857" checksum="98240D0E1F40C78A" modified="2022-01-19" version="1" fragment="single">IFPPVFFRPMESTQLQKSYPEIFRSANIDQFIGKVSPKTHCSQIASLIHDRATREAMLHQRLEFVLTFHFEPDLTCPYGKGRDWWYVLRALEPEPRPVDGKTYPHLALYLLDIKEAREDSIFFSEFSALVFAMRGRANQRKVDSETEVEAYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VI90</accession>
    <name>A0A8G1VI90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_492417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510939.1">
        <property type="nucleotide sequence ID" value="XM_025663775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VI90"/>
    <dbReference type="GeneID" id="37167177"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="207" mass="23820" checksum="932C652ACB2EABBA" modified="2022-01-19" version="1">MSPPSLETSPSHDTISIICQLNAARDRLRQTVHQTLSGRITLILQRSLSPCCERTVCTFLRELQKIQAWPFDNCFAKHGIDELLNRLAHFDADRMHKYIDPATNSQFNCVMCNMDWKTIVESTATRVAGYFDGLCLDCALRTDENPPPGGQYDKKDYWDCLESHDRYDRKCRIQHGEPSWYFSFMGEQRELQATPAHGVGLPYRLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIX5</accession>
    <name>A0A8G1VIX5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_493247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510085.1">
        <property type="nucleotide sequence ID" value="XM_025663819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIX5"/>
    <dbReference type="GeneID" id="37167221"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034324872" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="40"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH52163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="574" mass="61817" checksum="BEF5FF851CD4F4D3" modified="2022-01-19" version="1">MKLLIWGPLLASAAYGRVIGTRTQSKSTSSSSAAPVQSPTVYIDTYESTVQGNRSQYISSVYNFKAIPFASAPTGAYRWRHPQHVSGWTGVRDATEFAPDCPQPGSSYYSEDCLYLNIWTPDTATLNDVQNNTETGIGVVPASSSSKLPVYVWFYGGRFGSGSSSQALYDGAGLAAKGVVVVTVNYRLGALGFLAHPELSQNSSSGTSGNYGLVDQQAALHWTNENIAAFGGDPTRITIGGQSAGAAAVLDHLNSPLADGLFEQVIAESGAHYSSDPLIGSVAEGYRHLAVAEAQGTAYLTSLNLSGIAAARAAPVEVFLAGADASDVTYVNTVFANNSVYMEPPLFRPVLDGYVLPANYQEMLQQGNHTIAAVLTGGNRDENGATPNPGMTVESYTRQNQYEFGSVGLAAEFFRLYPAGNSNSSADAASNTFYQDQARISLWQWANEYQAGVARNTSGNSTVSTYTYYWTHAPPGQDEGAYHMSEINYAFNNLYATDKPWKPEDYAIADRLSDYWVNFLHSGNPNGPELPNWPANGAAEPVVMELGDAWEPVLVASAEKRSFMNKWFSNWPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJS9</accession>
    <name>A0A8G1VJS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_521787</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513891.1">
        <property type="nucleotide sequence ID" value="XM_025665220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJS9"/>
    <dbReference type="GeneID" id="37168622"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="9">
        <location>
            <begin position="419"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH55969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="529" mass="57540" checksum="7D89519328B8322F" modified="2022-01-19" version="1">MPSSAPVPSTGFQALILCGPGVSLNTFTSNPEEYPKSLIPIANRPMVFYPIDFCKRSGITDITLITPPSSLAPLQAALKQNPHLTSLPAPSVSVVAPKDLEMTMGTAELLRLPEVQECIKTDFLLLPCDLICDIPGESILEAWLVTQGALGGNPDGPGGEQGGRRGGLAVYYQTVGREESVKGEATDFVAVAPLGQDEAPVVSHLVDGPSALRFGLSKLLMSMPMDTVKERMEQEKGFLVRHALVQKYAQVKMLTSYRDAHLYVFPYWVKDLARHQEKLESVSEDLIGYWAKSGWQNGLGEKLGMNKIFHDQSQHDNKSHDGDLVEDEIDLNNISSTKVGSAASHSVEHPQILAYVQQGSTPFVRRVDSSAILLSTSLRLAKLESIEEVGRQAASPFAHNQKVAHPEGVAQRCTVTKSDCLLAENVTVEPTCVIKESVIGPNCHISSGARLTRCVVMDGAVVESRAQLTGCLIGRRARIGRESVLKDCEVQDANVVPEETDAKNEKFMVFEGLDDEGDEGMDDMEDFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJV5</accession>
    <name>A0A8G1VJV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">transketolase</fullName>
            <ecNumber evidence="5">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_450710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513981.1">
        <property type="nucleotide sequence ID" value="XM_025660441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJV5"/>
    <dbReference type="GeneID" id="37163843"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000012">
        <property type="entry name" value="Transketolase, variant 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF6">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="322"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH56059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="655" mass="72236" checksum="FBE832BF1BC579C3" modified="2022-01-19" version="1">MAAIGVALWRYVMRYAPHTPEYFNRDRFILSNGHTCLFQYAFLHLTGYRAMTFEQLKSYHSDRVDALCPGHPEIEHEGIEVTTGPLGQGIANAVGLAMATKNLAANFNRPGYDVVSNHTWCMIGDACLQEGVGLEAISFAGHLKLNNLTVIYDNNQITCDGSVDLTNTEDINAKMRACGWDVIDVEDGCYDIEGIVQALEEARASPEKPTFINVRTVIGLGSKVEGMAAAHGAAFGAPDVAEMKKKYGFNPDEHFVISDTVREFFQELPARGEALVQQWNSLVKQYSVEHPELGEEFQRRIHGELPSNWKDLIPSSFPDKPTATRASSGLVFNPLAKDIKSFMVGTADLSPSVNMIWPGKVDFQHPDLRTTCNINGNYSGRYIHFGVREHAMCAISNGLAAFAPNTFIPITSSFFMFYLYAAPAVRMGALQHLQVIHAATHDSIGMGEDGPTHQPIELAALYRAMPNLLYIRPGDSEETAGAWLAALEAKKSSSIISTSRHALPQLKQTRREGVAHGAYVLEEADAAAVTLIGVGAELSFALDVAQQLKETKGIAVRVVSFPCQRLFEQQALDYKRTVLRRHQGIPAVVIEPYAPNGWERYADAGINIRRFGHSLPGKAAYKFFGYETGVMAAKVGDYLDRLEKGEWQRGEFVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJZ9</accession>
    <name>A0A8G1VJZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CCCH finger DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_61144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514116.1">
        <property type="nucleotide sequence ID" value="XM_025665528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJZ9"/>
    <dbReference type="GeneID" id="37168930"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH56194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="352" mass="40028" checksum="90B24F0F6F772228" modified="2022-01-19" version="1">MPPKKQQDQPKKKKATVEDKTFGMKNKKGGSAKKQIAQLQAQAASNKNADAKKKEAEKARREAEKKAAEQAKKEALELFKPVQVQKVPFGVDPKTVLCVFYKQGNCEKGKKCKFSHDASVERKAAKKDLYTDSRDVKAAEEEAKKKDTIDDWDEEKLRKVILSKHGNPRTTTDKVCKYFIEAVENQKYGWFWTCPNGGDKCMYKHSLPPGFVLKTKEQKAAEKALMDKSPLNTLTLEDWLESERHKLTGNLTPVTPETFAKWKKERLDKKAAEEQARKAKETTGRTLFEEGNWRADDESSDEEEDDGTWNLEALRRETEKIRERKEEERLAALHGTPVPVSNDETIAQEGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK02</accession>
    <name>A0A8G1VK02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_489404</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513923.1">
        <property type="nucleotide sequence ID" value="XM_025663602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK02"/>
    <dbReference type="GeneID" id="37167004"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034949627" evidence="6">
        <location>
            <begin position="19"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="FAD linked oxidase N-terminal" evidence="7">
        <location>
            <begin position="122"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Berberine/berberine-like" evidence="8">
        <location>
            <begin position="524"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH56001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="618" mass="68115" checksum="EC3D1A8784E97468" modified="2022-01-19" version="1">MLINLALLLLEVSSLVRASFACRCQPSDACWPSGDEWKHLNESISGRLVRVYPIGHVCHAPFFNQASCNQLVHLQYDSNWRAEQPGALQSFNWENWPGKNESCTIEANSSSVCGQGRIPLYSAVVHSVAEIRTVVRFAKQRNIRLVIKNTGHDSTGRSGAPNSLQIFTNRLKDITFHDDFVPSQGGWEMDKVDATGVPAVTIGAGVIVGELYAAAAARGLIVVAGECSTVGVAGGYLQGGGVSTVLSPLYGLAVDHVLELEVVTAQGDIISADKNQHEDLFWALRGGGGGTYGIVTKATMRTFRDIPSVIPTIHFTYPQANDIFWPTLTQIVGLTQSMSVHGNSGQYIVGRLPSYHWYVNWTMFVWDDNDSKLLEEQVLPFLNFLDWLGIEYQYELAEYSRISAFLTIPKQADIGGIGYLQSSVVISESFMNSIAGPSKLTASFSKLVLDPGALITVNVLGGQINLNTKDEDTSVNPMWRSSSLLVVLMQSFPPTPEAQSAAHQTLSQINTPILASIDPEGGGVYFNEADPDQSDFQNAFWGRHYGRLRQIKSQWDPDGLFMVRNGVGSEDWDVERGSRDPLRSAGQLFDWEDKDAKKDVVWFYKCFWSVAFLARRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKE0</accession>
    <name>A0A8G1VKE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Methylenetetrahydrofolate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="12">1.5.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_423334</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.15" evidence="12"/>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514373.1">
        <property type="nucleotide sequence ID" value="XM_025658010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKE0"/>
    <dbReference type="GeneID" id="37161412"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004487">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01079">
        <property type="entry name" value="NAD_bind_m-THF_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000255">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000012">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035812">
        <property type="entry name" value="m-THF_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="14">
        <location>
            <begin position="17"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="15">
        <location>
            <begin position="151"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH56451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="334" mass="37134" checksum="79D2C8E8FC077C1B" modified="2022-01-19" version="1">MATTSDSVPASCKVMLSKHVANRLLAEVQEGVHTLEKPPHLVGFLANNDPAALMYAQMTEKTCQENGFRYSLREVARDDLEQAILAANADSDVNGIIVYYPIFNNRQDQYLQQIVDINKDVEGLSHRYIFNMYQNIRFLDPETKRQKCILPCTPLAVIKILEYLNIYNTILPYGNRLFGHTICVVNRSEVVGRPLAALLANDGACVYSVDITGVQKFTRGEGLKKGRHEVVDLEGKTLKDVAPLCDVVISGVPGEKYKFDTSLLREGAVCVNFSSEKNFGPEVKEKASIFVPSIGKVTIVVLMRNLLRLIQNSRMDDVKPAEATERPGTLEAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKL0</accession>
    <name>A0A8G1VKL0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_522237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513324.1">
        <property type="nucleotide sequence ID" value="XM_025665248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKL0"/>
    <dbReference type="GeneID" id="37168650"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034120594" evidence="2">
        <location>
            <begin position="20"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="635" mass="67991" checksum="F6847B728FE4F4CB" modified="2022-01-19" version="1">MAGSKAVALLFLLVNLTTASVIPRGEASSSAVAASASASAEASCWRYTLPTTLTEDDIEQNEDDTTSSTRRRGLNYFDRRDHTKTEKLGTCDLGQTIYKPKYFRSKNIQTSQNKVSGYSFLGYFIPKLDTCDAAVTFTTIANAADVSKTTAGYWDDVEASAQQKYLDLGAQINKNNQEMPHINVDHVYELQILDAFLTAMIDEYKFCDSFKDWFLTIDSTFKNKQGVNKPRLQKLYSYLPGETYPDLVAMDSRLNSYKAPMFGSEELSGMASVDGTGDARQGSALSIMNTLAVVVSMLRDNSVATYFKNANTRMYKAFLGIDDLMSQQKSCNQDLDLPQPKNGWASAYESWMDKFLSTQAAAVSTRISSVSAQVTSTEAAGAKNIYGKALDAFNEKYPTASWKWDNGKLLDWSATDGTAFAKRDASSAAVCTPTATPSSSAVKSHSASSKATPSQTGSANTASETASHTVKSTVTSTSQKATITPATSTSTKAETTTKSKHGSGSSEAAQTTKSTSSKPKGTETATTKSSSSSAKDTATITSTKTTSTATPDSKDTSTKDTSTKDTSTKDTTTTTSTSTKSKETTTSTKTSTTTKSTKTATKTTTKSSKETKDSSSSSSSCKKKKCKKGKCTCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL14</accession>
    <name>A0A8G1VL14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_379858</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512170.1">
        <property type="nucleotide sequence ID" value="XM_025656359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL14"/>
    <dbReference type="GeneID" id="37159761"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045122">
        <property type="term" value="P:aflatoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000047">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH54248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="492" mass="55918" checksum="DA23BA629857386A" modified="2022-01-19" version="1">MSNQSPLNPPFQLPTYFTALALYNLYFHPLSNYPGPKYAAVFPLWYAYALLRGNFHEDMRHLHAHYGSVVRYAPNELSYTDPRAWTSIYSGRPTGTEFPELGKDPTFYAGFASGNKSITTAGFHDHNRFRKKLAPAFAEKSIREQEPIIKGYVDLFVQQLGQRAGEVVDMSAWFNFCTFDIIGDLGFGEPFGCLKRGAYDDWVRLIFLALKTSMLIQISARFPGLQSLLLWYLLPAELARKRLAHIAKTTEKVMRRLGRETDRKDFMQYLSTGTPELSFDELANNSSTLIVAGSETSATSLAAVTFYLLKNPEKMRKLRKEIETAFSMEEEITIQSVAGLKYLTACLEEGWRLYPPIPSGLPRQVPGEGFEIAGRWVPGGAAVSVHSWATSRSPKNFRNPDEFIPERWLGDPAYKDDNLQSVQVFHVGPRNCIGKSLAYAEMRLILARLLFRFDLQLMPHSSNWAEQMSYMVWERGPLDVRVTERRTASDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLI1</accession>
    <name>A0A8G1VLI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_450466</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514374.1">
        <property type="nucleotide sequence ID" value="XM_025660381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLI1"/>
    <dbReference type="GeneID" id="37163783"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="72"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="195"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="425"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH56452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="556" mass="60070" checksum="EA9411840093CA91" modified="2022-01-19" version="1">MFRNALRQSSRTVAAASATGRIASARAAVPGPLSGASKQIRSYAAEAKASPTEVSSILEQRIRGVQEEAGLAETGRVLSVGDGIARVHGMTNVQAEELVEFASGVKGMCMNLEAGQVGVVLFGSDRLVKEGETVKRTGEIVDVPVGPEMLGRVVDALGNPIDGKGPIPTKVKSRAQLKAPGILPRRSVNQPVQTGLKCVDSMVPIGRGQRELIIGDRQTGKTAVALDAMLNQKRWNNTSDESKKLYCIYVAVGQKRSTVAQLVKTLEENDAMKYSIVVAATASEAAPLQYLAPFTGCAMGEWFRDNGRHAVIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNEKHGGGSLTALPVIETQGGDVSAYIPTNVISITDGQIFLESELFYKGIRPAINVGLSVSRVGSAAQVKAMKQVAGSLKLFLAQYREVAAFAQFGSDLDASTKQTLSRGERLTELLKQKQYSPMAVSDMVPLIFAGVNGFLDTIPVAKILQWESDFLAHLKSNHPEIQETIEKEGQVSKELEAQLKEIIPTFNKSFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLW1</accession>
    <name>A0A8G1VLW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_449877</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515077.1">
        <property type="nucleotide sequence ID" value="XM_025660258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLW1"/>
    <dbReference type="GeneID" id="37163660"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH57155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="320" mass="35102" checksum="FA9F9F58F3E589FB" modified="2022-01-19" version="1">MDRSNKPAAIGVGASLPQPTISLRDNTVEATLPTGESVTVYLYGATVTSWKLANGKEQLFVSEKANLDGSKPIRGGIPVVFPVFGPPPSNHATSALPQHGFARNSNWEFLGKSSSEAFGRDRKEGEDAVKLDFGLSHPMLSEEFQKAWPYKFGLVYSVTLTKGSLETSLQVQNQGEQNFDFQVLMHTYLSVEDITNVRVKNLQQKEYLDKTQGGAAITETSEAVEINKETDRVYKALDPKVPIIVSTASDDQPLFSITREALTDVVVWNPWIEKAKGMADFGPDEAYKNMLCVEAGSVAGWQTLEAGESWEGGQTIRPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM17</accession>
    <name>A0A8G1VM17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_449266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516083.1">
        <property type="nucleotide sequence ID" value="XM_025660126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VM17"/>
    <dbReference type="GeneID" id="37163528"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12400">
        <property type="entry name" value="RRM_Nop6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000376">
        <property type="entry name" value="Putative RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034228">
        <property type="entry name" value="Nop6_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF51">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="170"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH58161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="313" mass="36704" checksum="C27BBB48A6831DE9" modified="2022-01-19" version="1">MGASDKKRKLAEEATSPEVKKAKREDKKEKKEKKEKKEKKKERKVEEEVVEEVPVVEKEEKEEKKKDKKEKKDKKEKKEKKEKKEKKEKKSESEPEAMDVDETPAEKEHEAEAEPEVTKEEKKEKKDKKDKKSKKEKKKQEETNTEAQPTNGETEEPAEQEGQNKKNARFICFVGNLPYSADKESLTKHFEKITPVSVRVATQVDKPTKCRGFGFIEFDNYDRMKTCLKLYHHSMFNDGKYPPRRINVELTAGGGGNSKDRKEKIEAKNKKLFEERQRNAKEIQKEKQRLEKAEETGVDDYAHIHPSRRPRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM79</accession>
    <name>A0A8G1VM79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell surface receptor/MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_36794</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515184.1">
        <property type="nucleotide sequence ID" value="XM_025655841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VM79"/>
    <dbReference type="GeneID" id="37159243"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH57262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="495" mass="52885" checksum="EED2FDB3AD560A6D" modified="2022-01-19" version="1">MDSRAPQDSAGLHHGSATTAPAELPPSGPVYKVYKRRFWGLAQLVLLNIVVSWDWLTFSSISTTAAEHFRVSESAINWMSTGYLFAFCVASPVVIFTLNKGGPKPAIITTSTLLLVGNWVRYAGTKARGGIFGVAMFGQILIGLAQPFCLSAPTRYSDLWFSDQGRTSATAVATLANPLGAALGELIDSFWATKPSEVPNMVLYISIIATVAALPSFFIPSQPPTPPSASSASTNASTPLLPAITQLLRTLEFYLILIPFSIYVGFFNSVSSLLNQILEPYSYTETEAGIAGGLLIIVGLIASAIISPLTDRYKHYLATIRTLVPIVAITYIALIFAPPSPAGIAPSYVVCSLLGASSFALLPVVLEYLVEITYPFSPEIGSTICWTGGQLLGAIFILVQDALKAGEDASPPVNMQNALIFSAVVAVVAAPWPLCIGCFGRDVRRRRLDVDRGVELGQEEEAAEVQGDDDAERRAGAGEDDTKKGFLGLSVAWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMI6</accession>
    <name>A0A8G1VMI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor RSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-splicing factor rse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_451000</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513655.1">
        <property type="nucleotide sequence ID" value="XM_025660496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMI6"/>
    <dbReference type="GeneID" id="37163898"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000068">
        <property type="entry name" value="Pre-mRNA-splicing factor rse1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="12">
        <location>
            <begin position="19"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="13">
        <location>
            <begin position="461"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="11">
        <location>
            <begin position="854"/>
            <end position="1175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH55733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1209" mass="133713" checksum="2DD1DBBC67B486B7" modified="2022-01-19" version="1">MATTSHMFMYSLTIQPPTAITQAILGQFAGTKEQQIVTASGSKLTIHRPDPTQGKVTPLFSQDVFGIIRSLAAFRLAGSSKDYIIIGSDSGRITIIEYVPSQNRFNRIHLETFGKSGVRRVIPGQYLAVDPKGRACIIASVEKNKLVYVLNRNSQAELTISSPLEAHKPQTLVFAMTALDVGYENPVFAALEVDYSESDQDPTGQAFEELEKHLVYYELDLGLNHVVRKWSDPVDRTASLLFQVPGGADGPSGVLVCAEDSVTYRHSNQDAFRVPIPRRSGATENPERKRSITAGVMHKMRGAFFFLIQTEDGDLFKLTIDMVEDDNGQLTGEVKRLKIKYFDTVPLASSLLILKSGFLYVASEAGNHHFYQFEKLGDDDEEIEFTSEAFSADPSVPCDPIYFRPRGAENLNLVETINSLNPLIDSKVVNITEDDAPQIYTISGAGARSSFRTLKHGLEVSEIVESELPSVPSAVWTTKLTRSDEFDAYIILSFANGTLVLSIGETVEEVTDTGFLSTAPTLAVQQLGEDSLIQIHPRGIRHILADRRVNEWPAPQHRSIVAAATNERQVAVALSSGEIVYFEMDSDGSLAEYDERRQMSGTVTCLSLGEVPEGRVRSSFLAVGCDDSTVRILSLDPDSTLENKSVQALTAAPSALNIMSMADSSSGGTTLYLHIGLYSGVYLRTVLDEVTGELSDTRTRFLGSKAVKLFQVSVKGQTAVLGLSSRPWLGYSDVQTKGFMLTPLDYVGLEWGWNFSSEQCVEGMVGIQGQNLRIFSIEKLDNNMLQQSIPLSYTPRRFLKHPEQPLFYVIESDNNVLSPSTRAKLLEDSKSRGGDETVLPPEDFGYPRATGHWASCIQVVDPLDAKAVVHTIELEENEAAISIAAVPFTSQDDETFLVVGTAKDMTVNPPKSAGGYIHIYRFQEDGRELEFIHKTKVEEPPLALLGFQGRLVAGIGSLLRIYDLGMKQLLRKCQAPVVPKTIVGLQTQGSRIVVSDVRESVTYVVYKYQENVLIPFVDDSVSRWTTATTMVDYETTAGGDKFGNLWLLRCPKKTSEEADEDGSGAHLIHERGYLQGTPNRLELMIHVYTQDIPTSLHKTQLVAGGRDILVWTGFQGTIGMLVPFIGREDVDFFQNLEMQLAAQHPPLAGRDHLIYRSYYAPVKGVIDGDLCEMYFLLPNDTKMMIAAELDRSVREIERKISDMRTRVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMN2</accession>
    <name>A0A8G1VMN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_488409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515619.1">
        <property type="nucleotide sequence ID" value="XM_025663529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMN2"/>
    <dbReference type="GeneID" id="37166931"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="58" mass="6443" checksum="2C0360AC5F32B657" modified="2022-01-19" version="1">MVGILTRATIRQANVNREHWNCSMSDEISQPVGFTEGLWKSLGVGDKAGKAVTEGWFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN43</accession>
    <name>A0A8G1VN43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_393053</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517431.1">
        <property type="nucleotide sequence ID" value="XM_025656867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN43"/>
    <dbReference type="GeneID" id="37160269"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="2"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH59509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="309" mass="34746" checksum="47BE0849017DBBD3" modified="2022-01-19" version="1">MSTIAVAGGTGGIGKTIVEALLQERKYRVVVLTQNNPKEDPVLRQTQQIQINYNDIDSIVETLEKHAVHTIISAIGIYTEEAAQSQMNLVQAAEKSSDTKRFVPSEYSFIQTEDLLPHDPSIKYWLDAAELLKKTKLQYTRVCPGVLMDYWGMPRVRTNIHQHVLGIDVANCWAGIPGDGNDKMSVTYSYDLAAYIVKLLDLEEWPEFSIFAGDDITFNELLKLAEEARGKKFDVVYDCAENIKAGQVTVPPFLTGVSEEEAREMTVLVSRLTIAGAFNLPKERMNALFPDIKPVKMREFLLNTWKDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN92</accession>
    <name>A0A8G1VN92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_448551</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in maceration and soft-rotting of plant tissue. Hydrolyzes the 1,4-alpha glycosidic bonds of de-esterified pectate in the smooth region of the plant cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516457.1">
        <property type="nucleotide sequence ID" value="XM_025659964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN92"/>
    <dbReference type="GeneID" id="37163366"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF13">
        <property type="entry name" value="ENDOPOLYGALACTURONASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034126731" description="endo-polygalacturonase" evidence="16">
        <location>
            <begin position="22"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH58535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="362" mass="37602" checksum="A2E983C8321394C7" modified="2022-01-19" version="1">MHSFASLLAYGLAAGATLASASPIEARDSCTFTTAAAAKAGKAKCSTITLDSIKVPAGTTLDLTGLTSGTKVIFEGTTTFEYEEWAGPLISMSGKDITVTGASGHLINCDGSRWWDGKGTSGKKKPKFFYAHGLDSSSITGLNIKNTPLMAFSVEADDITLTDITINNADGDSLGGHNTDAFDVGNSVGVNIIKPWVHNQDDCLAINSGENIWFTGGTCIGGHGLSIGSVGDRSNNVVKNVTIEHSTVSNSENAVRIKTISGATGSVSEITYSNIVMSGISDYGVVIQQDYEDGKPTGKPTNGVTITDVKLESVTGTVDSKATDIYLLCGSGSCSDWTWDDVKVTGGKKSSACKNYPSVASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN96</accession>
    <name>A0A8G1VN96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcription factor AbaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_487090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516279.1">
        <property type="nucleotide sequence ID" value="XM_025663432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN96"/>
    <dbReference type="GeneID" id="37166834"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0183">Conidiation</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0749">Sporulation</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="10">
        <location>
            <begin position="129"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="8">
        <location>
            <begin position="129"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="764"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH58357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="787" mass="88465" checksum="71FDE240BDB6296A" modified="2022-01-19" version="1">MAHWQTGCIVPQHQSALESIGAHTDRALQNTSGNVQTYSDNLADSSTVGRDDQLQQLAFKYPQPPVPTHPVPTVPTTLQPPQNLRLQSKKLRRLHSFGPSLIGPRSRPRSYLRSSKYLEYRSRPRRDTGKDGEPVWSDELEDAFQQALEANPPMGRRKWSERGKSYGRNELIAEFIYKKTGKRRTRKQVSSHLQVLDSFLKGDPDWERLVREEANVRSNNQHPPAGPRWGPAMDPPLSSHYGTHLHPTYHDPMRQAYGELPPTPFSMNASWPESNFSTIQGLGFGMWVNEPDKNDRIEDASHIYSRLQDDQRHPVAPISLNEIRNWQTSFPYLNSLMANSNGSLDCDIILIESNLKLMDDFPAARSKLGIHLELDFAQASAAGAPILSEMENWSSKIYMYENGQEIYQGRQEVARPTHTATHTKVKPHFESKWWANRFTKLTQDQKLAEDAGHHGHEQAREFLRHLTVVQEIRAMTPYSSRRMSNPYSGHPVSEKKRVAIILWKFRQTLPRDVVGTTTWRRVVSSDRIPHASPKAATGIDLPPPMSLADSILLNRPGPNVYHQPQPHELLHNNGVSQNPWPLYSTGQESVAQMFNAPFDFMSPLPKQEDRLNDKIAVTLGLDGFPSLQSHDISQPTSLNGPNSGTSILSMPEVPLSHSSHGPYSLEHDSHYVHSQPLGVNVHDNNALLNGMLVTSAQSIDDMNNSQASWMPPTTAMSGDIPGSHYPHIGFPSSEHHVAVPREPNPSHSYDFMPEELDKWPSSLPTDMNGGAHEHAHSYTASNTVQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN97</accession>
    <name>A0A8G1VN97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_437712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516472.1">
        <property type="nucleotide sequence ID" value="XM_025658634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN97"/>
    <dbReference type="GeneID" id="37162036"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22187" checksum="F2243B8F6E5A4788" modified="2022-01-19" version="1">MDYLTNLLPELQIRVIEYLDYISLAVLSQTSQYLRTNLQVQSPTTTPQQKILYLFAAEEWKSQENCLLNILYALVPDISTTLISKNILPGYPKSAAHEAEVVGRSVFVSSHDVHEILRSNQVAVGKAKRKPVTVSLVPDREPNILRPRWNEIQNTASSAGENSSIGDPPSSTDGEKPESTEYRLARSSRPAESQIHEGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNF5</accession>
    <name>A0A8G1VNF5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine pyrophosphokinase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_419622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516652.1">
        <property type="nucleotide sequence ID" value="XM_025657866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNF5"/>
    <dbReference type="GeneID" id="37161268"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="137"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="322" mass="36220" checksum="A4E032F7A0D55E26" modified="2022-01-19" version="1">MGKSNLELVIECDRFPYYQDSPASYLEHLKNYHVFKVAGCDATLGYILNSTVERFDLPSEWWAIDSDNRSVTLLAPADATPQQRSEIMAKTLNRAVELGTFDILKGWRNEMYPIYGPGGKFLLEMERSATPLFGVVSYGVHSTVYVEDENGLRIWVPRRSRTKQTYPGMLDNSVAGGMSTTEHPFECLVREAMEEASLPEDVVRANATPAGCVTYTYVRSAKAGGETDLVQPEVEYIFDVKVGADIIPKPCDTEVEEFKLFTIEETKQALANGEFKPNCAVVLIDFFVRHGILTPENEPDYLEIIARMHRRLEFPTASHVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ51</accession>
    <name>A0A8G1VQ51_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Galactose mutarotase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_392334</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518437.1">
        <property type="nucleotide sequence ID" value="XM_025656842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ51"/>
    <dbReference type="GeneID" id="37160244"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000014">
        <property type="entry name" value="Aldose 1-epimerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF6">
        <property type="entry name" value="1-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH60515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="452" mass="49476" checksum="78C10218F3D8D5ED" modified="2022-01-19" version="1">MRPSTRSGQGPLQLLGCCRSLLCPARITPRILVIYCCFFLLVTILLGVRMHVRSYLSAVLYGLPALTQVAAAKSTGDPFQLYTISAENITAKLIPYGARLTSLLVPDRDGNFQDVVVGYDDPKQYLKDSETNHTFFGAVVGRYANRIKKGTFSIGSDVYHIPENENDGEDTLHGGTVGYDQRNWTVTAYSNSSITFTLVDRAFEDFPGDVITHATFSVQTKVTPENPQGLPQLTTKLVSLALTETTPIMLANHIYWNLNAFKDETVLEDTWLQLPLSKRLIGTDGILIPNGTILDVDVYDSAPDFVSGKLVGQDIAKADGLCGDDCTGYDNCFIVDRPPQYAARNSIVPIVHMNSSTTGISLDVATNQQALQIYSCNGQNGTIPVKQSQVQRNKAEGVDGAEYVNQHGCIVIETEGWIDGINNPQWGQLSDQIYSPETGPAVNWATYQFGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQA7</accession>
    <name>A0A8G1VQA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_465592</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519563.1">
        <property type="nucleotide sequence ID" value="XM_025662069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQA7"/>
    <dbReference type="GeneID" id="37165471"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH61641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="490" mass="56257" checksum="FA7AC3AAB5322952" modified="2022-01-19" version="1">MFGLSAAALTSLLACIILYVCYNVFVHPLRRYPGPWLWAATRLPWCWYQAQGRLNQKLLELHLRYGHTVRVAPNELSYNSEEAWRAIYGPRSDEMGKDPVFSLRTPTGVQNVLTADRQTHTRQRRLLSHAFSEKALREQEGIIQGYVDQLMRQLAARANDGPQNMVDWFTFIAYDLIRDLSFGERFHCLNTAEYDPFVRSIRAISKELTFIQMFAYYNLLPFRQLFMPKSIAGARAQNMQRVIETVNRRVARNTDRKDFLHYILAAMETEKGMSRAEMNVNAFSFSIAGSESSATALSAFTYYILSHMSVYDLLIAEIRGAFEKYEQIDISSVTQLPYLNAVLQETLRIYPPVAVTLPRVVPANGAVIDNKFVPAGVTVGINHFACYHDPRNFYRPQEFLPERWLPECQEKEPFSIDRPKCCQPFSFGPRNCLGKNLAWAEMRLIAAKLLFLFDMELFGTGKGWADGQKVFGFWVKPPLLVRLVPRAGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQF3</accession>
    <name>A0A8G1VQF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_465680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519698.1">
        <property type="nucleotide sequence ID" value="XM_025662079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQF3"/>
    <dbReference type="GeneID" id="37165481"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH61776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="267" mass="29744" checksum="CD369E59E099F947" modified="2022-01-19" version="1">MTFYLPPPTIQSEYCTATTVYDPMPHLPIVQCNASITAQNIRKRKRETALEDITPALSNRLASSALHDTSPQFCLDNKTCLGDSAGVFTRQRCLHRKRRVFQQPPAYNKPPLTDGISYMLQSDSSQDTCISGVSSPPVSPRTIPPTPYQQPQTLFASASCLRPCHICHRRPTTREYVDAYADCDLCGGRSCYICLRHCDSVDCSGLLRTPTSGCQERPDDDEWQTERARNVCSACAVEGVTESGKEVIRCLECVQGLQSQWQALHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRK7</accession>
    <name>A0A8G1VRK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Kexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_516522</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519894.1">
        <property type="nucleotide sequence ID" value="XM_025664852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRK7"/>
    <dbReference type="GeneID" id="37168254"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000005">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 14" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034840991" evidence="17">
        <location>
            <begin position="20"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="737"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="18">
        <location>
            <begin position="490"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="651"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="788"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="808"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH61972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="843" mass="92306" checksum="5C8814A28FE4628A" modified="2022-01-19" version="1">MRLTGGVAAALGLCAAASASLHPHRSYETHDYFALHLDESASPADVAQRLGARHEGPVGELPSHHTFSIPRENSDDVHALLDQLRDRRRLRRRSGDDAAVLPSLFGRDEGLSGILWSEKLAPQRKLHKRVAPTGYTARSPVNTQSDPQALAAQKRIASELGLADPIFGEQWHLFNTVQLGHDLNVTGIWLEGITGQGVTTAIVDDGLDMYSNDLRPNYFAAGSYDYNDKVPEPRPRLSDDRHGTRCAGEIGAAKNDVCGVGVAYDSRIAGIRILSAPIDDTDEAAAINYAYQENDIYSCSWGPYDDGATMEAPGTLIKRAMVNGIQNGRGGKGSVFVFAAGNGAIHDDNCNFDGYTNSIYSITVGAIDREGNHPPYSESCSAQLVVAYSSGASDAIHTTDVGTDKCSSTHGGTSAAGPLAAGTVALALSVRPELTWRDVQYLMIEAAVPVHEDDGSWQDTKNGKKFSHDWGYGKVDTWTLVQQAKTWDLVKPQAWLHSPWQRVEHEIPQGEQGLASSYEVTEDMLKGANLERLEHVTVTMNVNHTRRGDLSVELRSPDGRVSHLSTPRRPDNQEVGYVDWTFMSVAHWGESGIGKWTVIVKDTNVNEHTGQFIDWRLNLWGEAIDAAEQPLHPMPTEHDDDHSYEEGNVATTSISAVPTKTELSDKPTGGVDRPVNVKPTTSAMPTGSLTDPIDDEELEKTPTAEASSTASPSPTSASDSFLPSFFPTFGASKRTQAWIYAAIGSIIVFCIGLGVYFHVQRRKRLRNDSRDDYDFEMIEDEDELQAMNGRADRSRRRGGELYNAFAGESDEEPLFSDEDDEPYRDRGISGEQEREGDGEHSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRR0</accession>
    <name>A0A8G1VRR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_21876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521271.1">
        <property type="nucleotide sequence ID" value="XM_025654671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRR0"/>
    <dbReference type="GeneID" id="37158073"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="850"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1053" mass="116395" checksum="BD5BA20660F283CB" modified="2022-01-19" version="1">MEVLDLPKRNSPISQSTAVAMGPTSPHPEEKASDAPYMVDDDFAGDDEDGDDDSISPISERAPPWSGTRWARFFPELSSHFSLASPTNSTNPPFPQFHTKGPPHIDGPSQQPERRSKGPSSLSSEDVADNRSSSYTSRSSLTSQGSEATSPVHKLADSLHITSPTRAGVFDESKYAHQIPPPFPSRSSIAQSKEKPLPQEPPIELTPLSIRHKTPQMHDRRPGYVGRLEPPPRSKKHASHHHPTLSQACNDLERTLAGLGEQPQTPGQLSPRSPLQILDGPLQISRGNMDMVATRPAPRPPASVHNNRQIHKVKSREDVKQTKKSLKNKPSFSFSVPAFGRKLSRVHQRSTSNTSSKSEPESYRASILHQPAVAELGDGEIAELQGSSVIGVRERPLSAGGEKELRMRLPRLQTKEMGESGRKRDNFHSTHEDPEQLRRPHERARGASVGDKYFVSYSKLDGIPATHQHQQTSQTSAMVYELEGGSPQPPAELQGDTTTAIDVPVRVSVSVSVGAMPGTLPDRVILTVLEHITSLDDLFNVAVARRDFYRVFKKHELKLMRIAVFAMSAPAWELREMSPPWDTEWQFVLDPDAPVPEYTPSRYLKRYAEDIYTLALLKSLILARCGTFLRPETIRGLSGTDDVRAAEVDDAFWRVWTFCRLFGSGKGREGDIAGQLDWLRGGKVARNRRVSEFTSIADPYDANSVLFEPPAGFGDGNTGGLSKEQLLDMTEIWTCLGVLLQPMHGKCIEARATGVFDGHNVEADDSAKEEAVLEEWTYYILTLGLSAVLVLGSIHPYDNTTAVFQRAHSMGLTNWEASDTGASRSSFLREAVSKACQPRGSSTSQVSTRSPGFGSPPSGSHDVSQTSNVPGDRESSPDFHRRRQAAYSAQLRNQRQQQPSPPNPMLAEERPISHYATIMSRLEGLPPAPQPPMSVSRIEIPPTTHSYVTNVSYMQPLQPVTPVYYPPQVRDPVDHAIDIMVRELGFAEEDAKWALKITDSGEGINMNAAISLLTRERRTHEQSSRGFSLRKRKSFLSSVINSPESRHSGWKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VS39</accession>
    <name>A0A8G1VS39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_443891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520477.1">
        <property type="nucleotide sequence ID" value="XM_025658892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VS39"/>
    <dbReference type="GeneID" id="37162294"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="298" mass="31004" checksum="FAC728E2F42A3D05" modified="2022-01-19" version="1">MSFAPPSGPPPPSVPEGWKAQFDDRYKQWFYVDLRTGRSQWERPEGPTYQEDSQRPPSGPPPSYDASSPGPRPSSAAAGGDKKPLGSRNPYNSQPDSTLESDARLAAQLQAEEEAQARRRSPIPPAQAQSGAASDYYAENSSSRVQSPQGPSTSPAPKQERSRGFLGKLMGRHSGGGSSSSSAGGMGYSRPPQQAAYGYPQAGYGGYPPPQQAGYGYSSYPAQGGYYAQQQAPQRRHNGMGTAGAAALGVGGGLLGGFLLADAVEDLGHDFDGPPPGDYGGGGFDGGDFGGDDFGGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSE7</accession>
    <name>A0A8G1VSE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LCCL domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_9732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520779.1">
        <property type="nucleotide sequence ID" value="XM_025665819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSE7"/>
    <dbReference type="GeneID" id="37169221"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF1">
        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="230"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH62857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="656" mass="72637" checksum="B4682D033A824E75" modified="2022-01-19" version="1">MRPEHPSRSRSRSPSSSFGKTSQDYPLAVFDPNENDSESSQFITVGRESSDSVRPDQRETTNEPLLPTSTHHPRRIAPEPFSCTLSGIRAWVKGPPYPHRYQITPWLQRWQTAPGRLVERYFPSTRAKVWLLLGCICTWGVIFLSILHSSVAGQQVSGYGVPVKLSCHARLWPNSTDCGLNGDSCRPFDNGAFAFRCPASCADAMLLEPYFVGPQEYNYRPLVIGGTADGDNTDAIYRGDSAICPAALHAGLIDSQKGGCGVLRRTGERTKFPSVIRNGIESIGYASYFPLSFTFGGESSETSCQDLRWPLFTFSVIVTTLLSLFITSPAAFYASIYFIVYFQVALSSDPPYSPDYYEVVSTALGRFLPCAFVGFAMYYFCVRKTLTDLTAHWDKTVLWLGSCWVGALNTDTFDKIPISRLTPHDIQQQPGAIPALIIIIGLLVAIVLTQAIAFRREGRMPKMLLLYGIMVCGVIALMLVPHMNLRIHHYVLSLLFLPGTTLQTRPSLLYQGLLIGLFINGIARWGFDSILQTSAALLDGAQLGSVLPVIGAPAILSSQNIMFNFNDVDKDADGISVLVNDVERFRAFKSDDGMLESFNWTRHLDGEPEYFRFGYIKVNALGGIWYEDFTRPGTWESEGDWVLPDGDSGDDSALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSZ4</accession>
    <name>A0A8G1VSZ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LysM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_483313</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521392.1">
        <property type="nucleotide sequence ID" value="XM_025663151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSZ4"/>
    <dbReference type="GeneID" id="37166553"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="43"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="142"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="220"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH63470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="386" mass="42591" checksum="2A761779F10FF198" modified="2022-01-19" version="1">MVTTNVTYSTRNPITSYNQTITPIDTAWPPTKTHPGQPKDCDKWYLVAPGDTCRSIYQRHGNSITMDELLEWNPDLKADCDYPIAGYWVCVGIKRPALTIIYPTTNDTVPDPTPWTPRPTPTETSVYPPTKTQPGLAPSCSAFYEAQPSDTCDQILASNPMLKFPLLLEWNPALKSDCSGILPGYFYCIAAYNDTNRPAPPTVTNQPYPLKPGTAKNCTAWYKSDDGDTCDLIVEMFGTFDKAQFVAWNPDIGVECYGLESGYYYCVADPSTPKTRTRPVITAMSFPTAHSRRQPGVTKDCNKWWLVSIHDDCYDIMHFNGITMADLYTWNPALSGKRNCLEGLVPDTEVCVGVMSSSSSTTAAPSSTVPGASFKTGLVTVMGERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VT73</accession>
    <name>A0A8G1VT73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_444916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521617.1">
        <property type="nucleotide sequence ID" value="XM_025659139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VT73"/>
    <dbReference type="GeneID" id="37162541"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="209" mass="23310" checksum="6E2B7504617A86F8" modified="2022-01-19" version="1">MSTGYRMPQHASRMEQSTTNCPCSINGLQIITELRTVQPVVELGTVLDIVQRVYTHGKDVLQCQDCRKSPHSSYVMLPALAEQCLSLFEAVCIAYNITRGNMLFDPSVLAFEEPLPQFICMRSKTVLGQIELDERESVMLVRTLLGRNLMKILEVLETLQKIFRSLGKEASEGGRCAGPATLRACESSVEATMRRFAVFMKQVEDNSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QPM7</accession>
    <name>A0A8G1QPM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_473098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509833.1">
        <property type="nucleotide sequence ID" value="XM_025662600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QPM7"/>
    <dbReference type="GeneID" id="37166002"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH51911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="94" mass="9961" checksum="6C3FEBD042E33008" modified="2022-01-19" version="1">MSLTRYTAPIPQGAKVVETREQLNQVVRENPETVLYDQDGGYMLKDESGTVVAIAADSLCPELDQAVAEVEALQAETKLAGNAGDQDASIPPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQL0</accession>
    <name>A0A8G1QQL0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_211170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825089">
        <property type="protein sequence ID" value="RAH52003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509925.1">
        <property type="nucleotide sequence ID" value="XM_025654615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQL0"/>
    <dbReference type="GeneID" id="37158017"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000460">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="42"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="484" mass="53199" checksum="1BCFE2FC85364109" modified="2022-01-19" version="1">MAGGKRPDVHPVIDLEKDMVGWDGEDDPKNPRNFPVSQKWFLMILVSTITFISPFASSVFSPGVVYAEEEFDVTSTILGTLSVTGYLIGYVTGPLFFSPLSEMYGRRIVLSAANTFFVAFQIGCALAPNISALIVFRFLTGVGGSACLTTGGGVVADLFVAEQRGIAMAVYTTGILIGPVLGPLLGGFIAQRAGWHWVFWVLVIAGGTLSALVMIFNRETNHVVIIRRKTERLRKELNRPELYSCYEPNGADAKGSYTSTLGKRLIMPFYLLVRSPIVFPVATYLATLYGCLYLLFTTVTDVFKKSYGWSTEISGLAYLGLGVGFISGQIVFALVSDRIITRLKLRNNNVFEPEMRLSITMVFAFFIPVSFFWYGWSAQEHTHWIVPIIGLAPFAFGMVGIYNTLQTYVIDCYPRYAASGTAAMVVTRSLMGALLPLAGPRMYSTLGYGWGNSLLGFVTLGMIPVPMLFYKYGGSVRKSSQLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQP6</accession>
    <name>A0A8G1QQP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET9</fullName>
            <ecNumber evidence="12">2.1.1.372</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Histone-lysine N-methyltransferase set9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">SET domain protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_443643</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates 'Lys-20' of histone H4 to form H4K20me3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64456"/>
            <dbReference type="Rhea" id="RHEA-COMP:15554"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.372"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.372" evidence="12"/>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509810.1">
        <property type="nucleotide sequence ID" value="XM_025658884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQP6"/>
    <dbReference type="GeneID" id="37162286"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140943">
        <property type="term" value="F:histone H4K20 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10524">
        <property type="entry name" value="SET_Suv4-20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025783">
        <property type="entry name" value="Set9_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51567">
        <property type="entry name" value="SAM_MT43_SUVAR420_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="120"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="260"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="374"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="595"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="603"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH51888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="635" mass="71307" checksum="612CC5FB47D41F89" modified="2022-01-19" version="1">MPVSKAKSSPSDDRRDRLTLAKLASYDDVATDALVDRAYFWTNTRKNRTKYNPARGIRDDDVASTLLHDVIVNKDAAKAEEKLLSMPGLKKYLAKLPTDREKEWFRRHLRKYIQMYLPDSPFEVTTTNRYTVTEHEAAICARKFIKQGQEIKYLSGTLVPMTKEEEQDLDLKRKDFSIVMSSRRKTPSFFLGPARFANHDCNANGRLVTRGMEGMQVVAIRNIHIGEEITVSYGEDYFGIDNCECLCLTCERAVRNGWAPQLDSDQESPASTPAYDEPAPSEALLSPKKRKHVSDTDSESSPSSTPRKRTKFTRQSSKLRSEVVFSDLTPSIESSTVQPAGTGLSSQALSVPHAAAAETANDHVIDNKSDIHAESTAQSTTTTTADPDSPGSLDDSHRSSTSTAATSVCDNPVRIKVEETTETTVQAPILTVEGRLDLSTGPAEPERRMLGVDNDALSDLSDSLELDEKLGTVVKKSRKSRSKEVVPSVEVEPPRARVPGDYTKTSKLLAQAYDRWVDCRTCNAWFVQQDSYLTRRECPRCERHSKLYGFQWPKTDREGPGDDEERVMDHRTVHRFLYPEEEALISRKDRGVSFGITPTPELSEPHAETEDSEAGEDRRNTRASRRRTRSLRMTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQR5</accession>
    <name>A0A8G1QQR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G1/S-specific cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_198268</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510478.1">
        <property type="nucleotide sequence ID" value="XM_025654504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQR5"/>
    <dbReference type="GeneID" id="37157906"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000065">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="97"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="192"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="196"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH52556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="418" mass="47269" checksum="BDAD2103F1CC8FA1" modified="2022-01-19" version="1">MAYHKRPTSSYQPCDTFFVESYDEFPAPRMDPKEHAKLMARERQYAMAEQLSKITSEEFRDDVLAHMLDMDAATLPDVESIDIQTEIQWFMRPYLLDFLIEAHTAFQLLPSTLFLTINLLDRYCSKRVVYKRHYQLVGCAALLIAAKYGDKKDRVPTIKELKSMCCSLYDDDMFIQMEWHVLQTLGWTIGHPTVDSFLQMAVMDCPYDAEVEHLALYISEISLFHREFVSKPSSDLARASLALARCILNRTQPRHTEWASQYDSMTLVGLSQQLHQPSQVLSRKYSSAHYSRVSKVLEQFLARQASIASYTPPSPQTDVVQPEPKPYEGEIGLATPQKATQSSAMAHGYITPPITPENEAFANGGNPTFAKGTAGASACSPSPTPPPSMQYVSSHTYSQDTTYQQQFLQPNMSFSTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQU0</accession>
    <name>A0A8G1QQU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_464412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509846.1">
        <property type="nucleotide sequence ID" value="XM_025661980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQU0"/>
    <dbReference type="GeneID" id="37165382"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="63"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH51924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="308" mass="34267" checksum="340F5B9D9CAD3DB9" modified="2022-01-19" version="1">MAVRTFFETVTIDQFRYAYSPGTSARLLEAWARRTHTTLNTVKLPDGTTAFWLGNPDAERLLLHLPGGAYCFPASPSHIDYSTSILKHLGQAGIDAGMLFLPYELTPTAQYPHQMKQAVALLQYVIEDLGKRPSDIVLLGDSAGAHLILSVLSHLAHPHPHIPLLLLREELAGALLLSPWMGESRTDYDSCRRNASRDLVSPGLLTYWADMFLGDAEFDSYNRPAGAPEGWWRDLPVEEIFIGVGGYEVLYDSIIKTARKIKAEHTRVTISIAHREFHCEALSPFNPGVASPDQYRALLAWLKGTLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSA9</accession>
    <name>A0A8G1QSA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UMTA methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_454359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825089">
        <property type="protein sequence ID" value="RAH52021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509943.1">
        <property type="nucleotide sequence ID" value="XM_025661268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSA9"/>
    <dbReference type="GeneID" id="37164670"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF96">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="285" mass="32364" checksum="A6F0A500895BF747" modified="2022-01-19" version="1">MASSKTELDYRVTDDVGYGLGSETAAAFRLNGIFYFWKEHLGFNIHPTIRESLQTPNPRIADVATGTAIWLIDLAKELPDATLDGLDLTLDMAPPVEWLPPNITLRQWNIFEDLPEELVEQFDLVHLRLLLPVIQNGDPSSIIQKITRMLKPGGWIQWDDLNIREAKIFKARPELKIEALEYLSRFWNTGERQEWIGRLPQSFEQEGLKRTSIDRYENLKQYLKADCEGYIVTCEETARTLARKGKVDEAKEFSQIVHQASLEAAAGAAVVATRVVCIGQKPVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSE7</accession>
    <name>A0A8G1QSE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_464531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825095">
        <property type="protein sequence ID" value="RAH51719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509641.1">
        <property type="nucleotide sequence ID" value="XM_025661992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSE7"/>
    <dbReference type="GeneID" id="37165394"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH51719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="268" mass="29830" checksum="BCDB5FBE67EA4D61" modified="2022-01-19" version="1">MPLTYSTIPLKVNGVRLEISTIHNNKLNSNPPIVFLHGFGSCKEDLADISVHPSFQEYAYLAFDAPGCGRSQTDDLSVVDIPFLVATAEAVLAHFDIDRFHLMGHSMGGLTALLLAHRHPDRVLSFVDIKGNLAPEDCFLSRQIFQFPADDPEAFMDAFIARTATAESYASPLYASTLRARVRSGAVRPIFESMVRLSDEEDLMGMFLRLPCRKMFMFGEENQGLSYLPRLEGEGVDLAMIVESGHFPMYSNPVEMYRKIAGFLGSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSJ0</accession>
    <name>A0A8G1QSJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_508352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="RAH52032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509954.1">
        <property type="nucleotide sequence ID" value="XM_025664459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSJ0"/>
    <dbReference type="GeneID" id="37167861"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034978801" evidence="2">
        <location>
            <begin position="23"/>
            <end position="528"/>
        </location>
    </feature>
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            <begin position="27"/>
            <end position="499"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="71"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RAH52032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="528" mass="57367" checksum="4B4BFB337394C81B" modified="2022-01-19" version="1">MRINERSTRGLSVLSLLAPVSATLYDQTIQLAQGKVQGAAAFNESSAPSYISNWKNIAVWKGIPYAATTGGENRWKPPQSAPSWNGTRKATSFGPSCPSLSAGDGVSEDCLSINIWSPATATDAKLPVMLWSYAAGGESSQSTYDGAGMAAKDVIFVSYNYRTGPLGWLTLHELAEETGATGNYGLLDQIEALKWVYENIAAFGGDPESITVAGQSFGSGAAYHLVNSPRTKGMIKGAIAESGLKDPYDPDLWGYGSDYRNMTWAYAFSKTYAESLNATSVADLRSMNLETVLSGTGVSDFTGFDPVLNYHAIPNKYIVNLDEGAPNDVPILVGNNKDENGIDLSTTYTVAEYKSEINSTYGPYAAELLALHPAENTTQATAAYNSILRAGYCTSTWSWAKRWNQSSTEPVYYYLWTYSPPGSDGATHGSEVSYALNNLYAQTTSSYTDTDYEVANIMSSYWANFVKTQNPNKGGSYNNGTLPYWGPNVPAQQNTFELGSLWKKIAFATAKEIQLYLEYFKYATPSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT42</accession>
    <name>A0A8G1QT42_9EURO</name>
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        <submittedName>
            <fullName evidence="11">CDP-diacylglycerol-inositol 3-phosphatidyltransferase PIS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_384126</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
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        <property type="protein sequence ID" value="RAH52332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025656537.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="37159939"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Cdp-diacylglycerol-inositol 3-phosphatidyltransferase pis"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="238"/>
            <end position="257"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH52332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="286" mass="31497" checksum="3D4E7FEA62380C8F" modified="2022-01-19" version="1">MGPRTRSQKAAAELEATDPSPAVNGTLQESPKNGAAVTADGDVEENVFLFAPNLIGYARVVLTMASLYYMPLHPRTCSLLYSVSCLLDALDGYAARYYNQSTTFGAVLDMVTDRCTTACLLVFLSSAWPRWAIIFQSLIALDMASHYMHMYATLSMGGSSQSHKKVEASRSWILYQYYHSRTVLFICCALNELFFIGLYLLSFSSPTLSPSLLQPVSTASPWSAGALEMARANKIDSFWPWVITGISAPVMALKQFINVVQLVKASKWLVEGDIASRKAMRNGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT70</accession>
    <name>A0A8G1QT70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial protein from FMP27-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_157584</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025654206.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37157608"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="3">
        <location>
            <begin position="1128"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="2">
        <location>
            <begin position="1248"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1653"/>
            <end position="2182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2516"/>
            <end position="2550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2778"/>
            <end position="2895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1894"/>
            <end position="1905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1907"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2523"/>
            <end position="2532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2588"/>
            <end position="2597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2620"/>
            <end position="2631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2791"/>
            <end position="2816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2831"/>
            <end position="2845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2854"/>
            <end position="2868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2895" mass="329062" checksum="50292875F8360ECD" modified="2022-01-19" version="1">MTLFSPTTVLVGFLLLYLSSFLIFAIVRIATGISIQRIGYFSLRRIAYVPRDGVQIELRGLGLSLHPPSFAQPTWLSIRLTELKLTLDPSALAKGKKSATKPDASVSEAPSEKESSTVPDNREDSSSIPKRSKTWRKLTRMKEQVKRLHRQIHWLKLVDVVAVNTTINLVEAGQIQVGSLSLGVDTRRKMVDRGKLFFRRKNQGPDEHRPAEWVMNVQNVLLGIDGAEPTEVLDNVRVNIHGLLHKDLEGLRDASIAFKIGRMHIPYDDVMTLMQRVKQSRQSSVEPTSIETDDEVSFSDFVEELDQPGSRDDTIVQAVADSKEFAGSILRGIQGIQVALSFFRLTRAFEPPSSKQNPVYLNVVSHELGIDLHRMDQKSPAHRMYFQRDDVAHQALLAAISLSVTLDDCSGETDNILYIPMATTTIKTTLPSKTISSFDDHNPEERNTNILFANLVVTSPSLDLEPKQVSRLLGLTQAKKASPRGKKRDNHRLISRLLPKASIKVSVHEPVVRFVLPISKPSDTPDDDYNLLISSISSISLDIESSHSSEGGVHYSLSSIYRVASHQLYYQTPSGVKHNLLTTESLEFKVLLSASPEVRVIASGSLNTCSAHMVNDEVNRGIHQVLEQFRAQTRHRRKASMSFEERKPSVLRRIPPWLLRFQFEATGLSLEIAGVDTSVSEVSRGVSFQLQSWTADYRAQKSEPTTVSFARRRTPSHSYIGDESSFRFPPTSPPRQKQVGATDGRRLALHVRGFEGFVIESEDYLEAEPFFSLPRFEVALSTMSDRLGPISNLNSVFKGVYLQYSLYRYYCLGVAMSVVQDAFMRKSPDIPETPMSPVQKEFAYPPSPRPSARGELMTYDVRATVIQLKTFMPADPPMLVQVYGLTAGSHRLSAPFAKAHLIRLHAQAPKLKGVWARIISMNNVRIDLRKMKLKHGTNLVEQRSIDVWADFIRLGVPHHMVMHRIFDNVINTSKALKQLHERFKGHSAEFGSVREPEEPKKIPRVSLRSKALLFELEDDAFEWKLGCIYRTGLIEQRQRLAREEAFELKLQKIKESDQRRSSSRLRARSSHRTLRSERVSGESRRSKSADPKPRKSLQDDKRGRGKKFRYDTEGAACLSCEAKVSAENAWFRLQEHNSRSWKDKIDSALRFQGTSIKEVRNLFSGADEAPEDVQETETVLSIPNRPALLAALISDINLVIDKPFFPLEDYPKFLNTIGKGMPMSMKYALLVPMSIQLEMGEARVNLRDYPLDLLHIPALRPGQSPRLPSWSLRTNFVIAEEYRDYKSARQVKLELVPSTELPDGTTSPPFAIEVWRSVSPVKTYSDPTIEINTSLPTSISWGMSYQPVIQDMMKIIEGFTKTEIDPSDRVGFWDKIRLSFHSRIKVAWKEDGDVHLRLKGSRDPYVVTGFGGGFVMCWRKDVRWEVHTSDDPKEFMSVRSGEYVLAIPDYSHEARYMAEATAQDLESTSTSSDLKNAAHFKKVVMKLSGDVKWAAGLVFERNVDEGQRSFDFKPHYDVVLQNPVHIDPAQRETYDAYRGFRSNHIHLSISVVAPESRNWSVDSVQPSASYNTVHLTPRFFTHFFNWWSLFSGVMSLPVRQGPLWPGITKTSKKFNRHLATVKYQLLFAPLFVAHIYKHKDREDYAEDVVTATGIKVRLDSLKLDVHQRREEVKTLAKGRLKQTKASAMRINQAELDLQSADFRAVSASIEGTNLDDIEQNKDDIISSFQQPVASVDLSRFTIPDQNLDWIDMDDFVELDWILPQESNPRTHILPLAFTPRFTYFRQTDHGQTAPEETGYSTFGDEPTHECVMSENNEPRRVQMELIRDRLAAVEAQTRDCSRTIGEQELRLAKEIDPDPALKSQHNDYLRQAETLNRRRTFLTAGLQRIERQLAREEKLPTERNPETFVQDSASRMGTDSDSTNDGKEADMDGLYSTPDDDLASDFNNRFIIHNIQLKWNNSLRNIILRYIHQVSQRRGFVYYMSRRAVKFILDIVDEQNKNKQKHSKLFRTASRRPSDAGGLVDSEDDDSIEDRIEQLLSDAKRYVNAEEQEHQSDQRRHSAPKSDGFSENIAPEFTPQNSYHLRLIAPQIQLQSEKNQKSVLVVAAKGMQLQVVSIMDKERVSDDVSGLVQRRFSLCMDGAQFFVATQKSLMNHLQFYAGNKYGNPPGSAWPPWLNLEALFDFELNPFGFSRIIQKTSASLRYDKYNNLRLKYNEEVAKGQSDQQYSVHDTEPRMDHISVDFPHFRAICDSAEYYSMYIIILDLLLYSEPLEKVRNERLERIMLTSDFSDLRGAPEMVFKLQSRIRQLEEIKEHFQIHAKYLDKQGWEDRLVLEKDLTQCEDELFFLMKAITSSQRKIDPNMSKTQGVLRWNISASEVVWHLMKDQTEPLVEFQLRNAEYDRTDNSDGSNHNLVAVERLYGLNLLPDAIYPQIIVPYLDQARGLNGPDDCMIKVKWHMLEAVAGIPVLDDFEVSLFPLKVQLERELGQKVFEYMFPNVGSTAFENGGFSPFMIKNMKPLDDSSDSDEEESPTARTHQDNSDLSTDDLQLKGPGAIELRLQPTLSLSEEARPKSQHRQLRGLALTPLHKDTKDNNHIRPSTSGGLTKKRSVDSLRILSRQPTEKSVANTSGGSGNNEEKKKFALGRLPNKGKKETPDDLSQMMSRASNYMTLAHVKVHDVVLCLSYKGKGEHNIEDLHDFVFRLPVLEYRNKTWSNLDLALRLKKDVIKALISHAPAILGNKFSHHRPSKQQQKRYRELASSTQLVHYSDTAVNASDHAHSMASADSNSEYSESQRSGKSGTGTSPLVRSNSLGSSMLHEPSGVIPDSRSASEVDVDARWEQSRRIVNPPTRPMTSGNAMPRSQTIKTWDEPEETTSHKTSIRNFGRKLIPSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTW5</accession>
    <name>A0A8G1QTW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_442812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510674.1">
        <property type="nucleotide sequence ID" value="XM_025658852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTW5"/>
    <dbReference type="GeneID" id="37162254"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000958">
        <property type="entry name" value="RNA binding protein (Rbm8A), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="46"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH52752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="164" mass="17953" checksum="A8325BCC14D4E844" modified="2022-01-19" version="1">MSTEMEVDPPVAQEEVEEEVPAQSGNNTSDPRTQASAVAVRSIEGWIIIATNIHEEASEEDVTDLFAEYGEIKNFNLNLDRRTGYVKGYALIEYSTLPEASEAIKALNGSKLLDQTIQVDFAFVRPPPSNNKGKNAGQRGGRGGRGRSRSRDRSRSPGAEEARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTY2</accession>
    <name>A0A8G1QTY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase MEC1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ATR homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">DNA-damage checkpoint kinase MEC1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Mitosis entry checkpoint protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BO85DRAFT_430408</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510798.1">
        <property type="nucleotide sequence ID" value="XM_025658291.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37161693"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000017">
        <property type="entry name" value="Inositol kinase kinase (UvsB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000031">
        <property type="entry name" value="Phosphatidyl inositol 3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058681">
        <property type="entry name" value="HEAT_MEC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25385">
        <property type="entry name" value="HEAT_MEC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="23">
        <location>
            <begin position="1436"/>
            <end position="2012"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="22">
        <location>
            <begin position="2125"/>
            <end position="2445"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="24">
        <location>
            <begin position="2429"/>
            <end position="2461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RAH52876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2461" mass="277749" checksum="8E911FF6506B95D2" modified="2022-01-19" version="1">MATNKRKESRLPIPEVADWNPAEPVSSTLAANLAPHLSSQGDGTLGLTKEAFSQLRHELLEGKYSHLQLNDSITDVKKLICIVLKAGLEPCIRDDRSELQGQLLDCLDIVQNAVDKAPLALLEMPEPEVLGKDAASPLYSCLVVWLVHLFSTWDSEPVEDRIGGILASMFNASHNHTKLWSSFVGITAFVRACTTELLDALDAYQSRARLTHVAGSPVVYPKQPCTLDLDRLGLRCGSLKRLIRLDSCAQTVRLCLDMLTSTINAHVSYNIPSKRQDLAWLSNSYRRLWKLAVLWRSKADTEDVTNQVQTFSQFLRFIKRFCDHVPHTSAKQRLAYISLQTFAETFALEMLNQASVLQLSLSHAIDSFTKAFTSEKDIMQSMGATVLPIKSNLALFSSFDTCLQVAIECSLVHCPMTYNSSNAKGAEAAFCGGHSTETVAIHEFPGSDHSSISGVGAVRMAKHRCLPRLDAYREGRNVAERLIANSLELLGCDRSGTLGDLSCAVLTSYIGLSEQDKLRFLCVLCNIPCALSGNLVDMLNVDTEDNFNCRICDSKCRDIEPESNSSILKSDELCQILNHIISNLSRTANLRIAATVALRRTLMHTSDPAHMQLASSAFGEFCLNSLRSSVRELRLTTGHSITSFVRRDLDHETRRGNFIVILDWLQSLSEKQETPLHETCILTLCHLAQFSNDEEMNIILLRLVEYLGHPNPFIGAVAYTELSGLAQHLSVTPAALFRPFWRTLSVTVVRNFQSRPYMAEQLCDLLGMKVDDFLRLTETYVLPYLVLTRKRDVIVRVGATYKDAKTPFDICSEKNNLASILAFLLSQPSPNPEESVMSALSEVDAAFRGRTLAELLRIEPILIACDLLKGLGDLGEDKGKRFLRALHLLAVLVPRKSGHTPKRANLIGYFIEEHVLGIITQFAHAVNDFQIRQPLIEKKRNIAAIGEMIKVARGHISSALPQICACLRAALEIQELCNNAFIVWRVLIISLQEEEVEPLIDQTLSIVIRYWDMFTEDTRKQAHELVEYIMQSHHELVRDIFNTMPSLASIPILDKHEATLNSMKEKMDVRSHFLAFIRRCQSDTATVVEQSLHELVPYLSQNEEFIHRSVLSEIPDPVVAQLTRSLLDCCVKFNTSSDVITKLSAECLGLIGCLDPNRVDTVKEKKGILVLSNFDSMEETFDFILFFLQNVLVETFLSASNTRAQGFLAYAMQNLLRFCGLDSAVANRSRDFRADEKYQRWLELPETVRNILAPFLTSKYTVTIGTLNTNCSYPLFTAGLTHGNWLRTFVQDLLQAGNGDNAKLVFSVCSRIVKGQDISIASFLLPFAVLNRTVSGSPQEKEDLRCELVNVLSHPLPDTHDYVYENIILCSQSIFEVLDYLSRWLQGKKKQINSLRNPSHPSNRNHKGTSRDALLDTYHSQAKAVEILLSSIPPEVISKRAVECKSFSRALFHWEQYIRQWKNQHSKQGGAAVEPLYQRLQDIYSRIDEPDGIEGISSHLHVLNIDQQVLEHRKAGRWATAQSWYELQLEKEPNDSEAQWGLLACLKESGQQDAILTRFEILKANNSSRKFLPFAVEATWITSNWGKLNEYLQQLSRLGRGEFNIEIGLALNAFRQGKYTEFWEHIEALRLSVAKSLTANSVVSLQSCHDSILKLHTLHEVESIARAKFEDSESNDSRTKLPDILDRRLDILGGYISDKQYLLGLRRATMELTNEFTDSDIAAAWLTSARLSRKGNFTNQAYQSMLHAARLNDRSATIEHARLLWKDGHHRKAIQTLEGAITANEFSSETATSQERTSSLIANNGEHQNMLLARAHLLLAKWTDRAGQTQSDAIVQRYREAIKLHPRWEKAHYYLGKHYNKILDLEKAKPLGKEAQIYLSGEASKLVVDNYLRSLAHGNKYVFQSLPKILTLWLEHASTVDQPFDPKRGDNEDFQKHTLSQRKKSLDDMHTQLKKYVNRIPAALLFTILPQVVARICHPNTTVYDLLTKIVARAVNSFPQQGLWTVLAVVKSSSKDRASRGINCLQKITEVNKKLKNQPSSDMRGMINQGQKFSEEMLRLCIARIEDKVLRVSLRDLKFSHKVAPCRLVVPFQAMLTPTLPASHKPEYLKGFRAFPRDPTTIEAILDDVQVLNSLQKPRRIGIRGSDGKVYNILCKPKDDLRKDQRLMEFNNMINRLFKKDVESSKRRMYIKTYAVTPLNEECGLIEWVDNLRALRDIVIKLLRERGIAPNYNEIRHDLNEACSDNSKLHLFTTKVLSKFPPVLYEWFIEMFPEAGSWFAARIRYTRSCAVMSMVGHVLGLGDRHGENILFEEGTGGVLHVDFNCLFDKGLTFDIPELVPFRLTQNMVDAFGAYGYNGPFRKTCEISLGLLRHNEDALMTVLETFLHDPTTDFIGKKKRRTHANAPETPAGVLENVRNKLRGLLPGESVPLSVDGHVDELIVQATDVKNLAAMYIGWCAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QU04</accession>
    <name>A0A8G1QU04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_492081</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511489.1">
        <property type="nucleotide sequence ID" value="XM_025663757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QU04"/>
    <dbReference type="GeneID" id="37167159"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="126"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH53567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="571" mass="63813" checksum="F462F8C8F31E5ACA" modified="2022-01-19" version="1">MSCLIQDSILGQFIRLVSRGRYFRFEEQKDPSLWQQYVNLNKSGRMAYSGRPDADEEPPERFSAADTESMTRVPSTAWSHNGRRYQGITGAVIDPEKGRDVTIVDWWSDRDPENPQHWPLWKKVVVTFEICLLTFSVYIGSAIYSAGIESVMSEFQISQVAATLGLTLFVAGYGLGPLLWSPMSEVPQIGRNSVYIATLIVFVALQVPVALAGNLGTLLAFRFLTGFFGSPALATGGATLSDMFAPRKRAYGIGIWGISAICGPVLGPLVGGFAAQAKGWRWTIWELMWLSGFTLVILIIFLPETSSSNILYRRARRLRKLTNRHNLRSEPELASEHLTARELAMMTLVRPFTLNFTEPMVFLLNLYIALIYGLLYVWFESFNIVFAGIYGFNLGQQGLAYIGILTGALITIPPYYWWMHKYLEPKFDPETGNVPPEARLPPAIVGGFFIPICLFWFGWSARPSIHWIMPIVGSGFFSVGAFLLFNPVLNYLSDAYPEYAASVLAGNDLFRSAFGAGFPLFATAMYKNLGVGWASSTLAFLGCAFIPIPVVLMKYGETLRKRYSRHARKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QU50</accession>
    <name>A0A8G1QU50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_442026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511625.1">
        <property type="nucleotide sequence ID" value="XM_025658822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QU50"/>
    <dbReference type="GeneID" id="37162224"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="257" mass="28820" checksum="39C4436E3590ED3F" modified="2022-01-19" version="1">MSYTLLKEEEAGITASRTRALSKIVALTLLVVAASFLGSRFALLGYRMPTFAIPSLSSSSSSSSSPSPTHPFFPKSTPHKITELQCGTSPAEDRSLGCVLDLLAMSWIRPAYYDKELTEEFLAVRNWTWTTDPWGKHHLHKSEVLDGDWEYVYVDHWCHVTHCAFLWRRMARAVHAGNLGMLHNYTAAYDHIEHCGDRLVANTGEEVVGVPAILMYPSCGPGSLGQEPPAYWIYEGEVQYDTKKQEGLFADQMKMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUG4</accession>
    <name>A0A8G1QUG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_509987</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825096">
        <property type="protein sequence ID" value="RAH51700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509622.1">
        <property type="nucleotide sequence ID" value="XM_025664520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUG4"/>
    <dbReference type="GeneID" id="37167922"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034832085" evidence="9">
        <location>
            <begin position="22"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="69"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH51700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="513" mass="55530" checksum="37F026A7CE67C639" modified="2022-01-19" version="1">MQLRHNCLGTWSGMWHFLVLGTSDSDKFSGDVNHLCPGNGTHDDPYIISWDENDALNARNYGAGRKGIIIAISGMSTLSVAFASSAYSGDLSAICHYFGVSDEASTLGLSLYVLGFAIGPLLWAPLSEAFGRRIMFLTTFSLFTIFNIAAAVSANFASLIVFRALAGTFGAAPLTNSGGVVADLYDAETRGLAAVFYSCATFLGPVLGPVAGGFLGETQGWRWIEGLLAFYSGIMLILGIVAVPETFSIVLLRRRAAMLSMQTGNFYVTSDDHRNPPGSLIRRFQEATSRPLRLLYKEPLVIVLALYMSFIYGTTYLLLAALPIVFQQVRGWSPGVGDLPFISIAIGMCFATVFMVFINRQYARKSRASQSGQRPPEARLLSAQVGAVFIPSGLFLFAWTNSPSVHWAVCMVGIAMFGFGNICVSLALVNYLVDSYVAYSASALAAATVMRSLCGAVFPLFTTYMYERLGIHWASSVPGFLSLACLPAAFILSKYGPQIRQRSKFAIAMSEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUS5</accession>
    <name>A0A8G1QUS5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit RPC6</fullName>
            <shortName evidence="6">RNA polymerase III subunit C6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_462602</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511864.1">
        <property type="nucleotide sequence ID" value="XM_025661857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUS5"/>
    <dbReference type="GeneID" id="37165259"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000431">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028763">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH53942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="355" mass="39226" checksum="CDF955FAAA25E76B" modified="2022-01-19" version="1">MASAGPSGSSVNELASRLYDACVNQFPSEHLFYQQDLLGLNIVPKNDLALLLSCAQSLVNQKLFRLLQGKNDRLAWKIISRDDAEKLRDLSPDESLVYNVIHSTGRSGIWVRAIGNRTNLHKSILDRCLKSLETKSYIKSVHNVKFPSRKMYMLANLAPSEDVTGGAWFTDGVLDENFINSVAGFIEYSVSRKSWYEAPSSDGPRNKRMKTADGGVAVKQEGAPKEYLPFPAGYQGYPTIPQLTAAVNESGITPVRLGEESITQLLEMLCYDNKLVSLNNGEFYKSVKNPEQVKSQQARKPRTDDAGIDDRLVKNGMTEAPCGNCPVFKLCAPGGAVSPESCEYFDPWLEKALGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUX7</accession>
    <name>A0A8G1QUX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_380420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH54017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511939.1">
        <property type="nucleotide sequence ID" value="XM_025656380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUX7"/>
    <dbReference type="GeneID" id="37159782"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="57625" checksum="4ED0AA1DAAA57115" modified="2022-01-19" version="1">MNDDRQLYEYTSGRWIYNEQTRLAERLTEFNVGALKSTVARSLQRSDTDIKCLSKSAEGGFNRVLQITMLDSTKVLSRLPYPSTQPKGLAVASEMATLALLRAHGLPVPRVYAYSTDATNPVGSEYIIMEELPGQPLGDRWFGLSDRERLKVLLQLVQLEAKSYAIQLPASGSIYYASDLPSDSPRVAVPDSNFCIGPDAALKWRFAERASLRADRGPCADPIDVLRNPALKELAWLRKYGRPRFPFERAYRESMDYRLSDPSEHIESLESYLKIAPRLLPSNEFLHDLEIVGLIDWQHAAVLSLFLAAGIPKFFQNYDDPESLHFRPPPTPELSDLDEEEKADALHDFRRRHTHFFYLAFTQRFNEPHFRAMDQTTNMLTRRVFSHVGDPWEGNNIPLQADLVLLTKSWHEYSTDPCPISISTAKSDSIMHLQSMQEEIDLQLKHIRNAIGISIDGWTPSEEYEAACARARQMKVDGLASLDTDYEREMTDRHWPFDDHNEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV52</accession>
    <name>A0A8G1QV52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetolactate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_404283</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512059.1">
        <property type="nucleotide sequence ID" value="XM_025657266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV52"/>
    <dbReference type="GeneID" id="37160668"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02002">
        <property type="entry name" value="TPP_BFDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006203">
        <property type="entry name" value="PRK08327.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="13"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="222"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="425"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH54137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="606" mass="64753" checksum="E306661DE4E18DDA" modified="2022-01-19" version="1" fragment="single">MSQETTVEAAPHTVADAFLEALAEAGIDYLFTVLGSDHPSIIEAYVRRQNDPARQYPKMVLFQHEFVAMSAADGYARMSHKPACVIAHVDVGTAALGQGLHNASSGRAPVVIFAGVAPSTLLGEAPGSRSEHVQWYQDIRDQAALVAPYSRFSAEIKSPHNVGSLVHRAVLMATTGSPGPVYLTATREILATPIPSPQTRLKPVPSCQLGSLSPQAVELIGSALLNAKSPLVVTGYLGRNHSAVQELIKLADTIHGLRVFDSELREVCFPATHPASVTRGTGAAPAVQTADVILVLDADVPWIPRRIHPSSEAVIFHIDLDPRKERMNMFDIGAAATFHADTGLALNQLNAHITSSSSLTDLQTSWTDRREAQSTAHAEGRARIDARATKLLETPDAPCNVDFLCSRIRELVPNDTIFVTDSVTNQVAMTEQLQLTRPGSHLTKGGSGLGWAGGASIGVKLATTRYDISNRPDVRVKSDTNSPFICNITGDGSFIFSVPSAVYWASHRYGCPFLTVILNNGGWNATRQCLVDVHPGGEAASLSSKELGISLVEDGPDYGGIAKAAANGNLWATRVRSVKELDEALREGVRVVVEEGRGAVVDVVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVH2</accession>
    <name>A0A8G1QVH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_523591</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511529.1">
        <property type="nucleotide sequence ID" value="XM_025665364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVH2"/>
    <dbReference type="GeneID" id="37168766"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001281">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001719">
        <property type="entry name" value="C2H2 type zinc finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="397"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH53607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1043" mass="117160" checksum="DD509CFC8759DB95" modified="2022-01-19" version="1">MSPENSDVGQETVTRPEAEEPTKDDSRSSSSGSNHNHDAPQSSTGAGQTKCSICQSTFRRPEHLKRHFRSHTKEKPFECAQCGRHFSRTDTLHRHELSHHNAGMEGGKDRTHRITVKTFRACYKCAIARVRCSGGSPCARCESRSLECQYPTERRSKAKTRKESQPSFTRNDASYDQSSHLAQTTWTNGTDLPPSRNGEQSMPPPFHYQMTQFQLQMPMSNASNAVPSKLSADHNNIKPGNRRSDETRMNGQTSSAEDNSTFSSVRDSTREVKKMRVPSVQYGDAGTQGLYSQIATSTEDMTEPAHRTEGLQSAKSSNRIAMMPTVGNQQVPMELIQPLLDQTTAPTINWLPQNLGNVSSNRRHSTNTYQKTSGILDTSLNQASWYPSAIHGADSSSLVSENVSQTPSGYTSLGGTTESPSQSHLNRRARNHSVDGAIPNSSSSRLNQDSWSLLCAASADASLQLQQANTRRQYLFPQTTETRGHATNEIKNGYRHVLEPSTYERIRSAFNQLCCVESILYPKFETDHLPGAETLSSFIDLYFVHFQPVYPIFHTPTFDINKCHWIVVLALSAVGCHFAGSQEQIECAPVFHEFLRRATNVEEEKYLVDRAPVWLLQASILNCVGILYSCDERARLLALNTFGNLVGFVNREKLLGHRPMQSLNGKTNEQRWVSWVEDEIRRRTGYLIWLLDCTIAYHFDKRPLLSLDESQATLPSHEALWEAESPEAWEEVRRGISDQKESSLYDAVLIMYIEKELVPDLGEFSQLLLIHALYHRMWEVGDYFRRPLSFWNPTSKKQSRHSALPSGSVWLPGIPSYSKWRNSACDCLDILHWAAGSTVNRSAGLEHPPILHLHLARIILLAPFREMRTLATSLAMTESHWHEREQTLEWHYILRWVKHDQYKARLAVVHAGALLRHARDFSSRSFHEPVAVFLATLVLWAYGACYSSLSDMTSCREAGHGMPEKPLIIHLDRPCDDELAQLFVREGHGMKAVLTGVGDVCAPQGPVETLKAGCLILAGLSSWGISKRFTAILGKLSEITSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVJ9</accession>
    <name>A0A8G1QVJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_382628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510917.1">
        <property type="nucleotide sequence ID" value="XM_025656475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVJ9"/>
    <dbReference type="GeneID" id="37159877"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="172" mass="19857" checksum="909ED21743A5EF51" modified="2022-01-19" version="1">MPSNWIDCVHAEPEPRFWTEYGSGPGAAVYGFPSKGGFYVLRECVGVELDFLRIDRFENTERPSKSDPDWQAKEEAHCDRMRRLGAKWFESYRDELEFMFFRTREDTDPHVSFGWPDGGGVWVLNTTYGRASELGTGIIYNAKNMEERCELIKRLGGIFYADPSDCPYLNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVP7</accession>
    <name>A0A8G1QVP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_454181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510207.1">
        <property type="nucleotide sequence ID" value="XM_025661217.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="37164619"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="447" mass="50383" checksum="B2A30A9CC39B232F" modified="2022-01-19" version="1">MVPRTRRSETLKRAASVDPEPASPGDETPPESKRVYPTDYYFGTREEYSDFFTQLTRMSSAALFRRGYPELMHDEFNQLHISLRSWTWSFSVTEEESHLSKDDKQEIIASLKGQCVQEDWDSIKALCPPAARRSLCDALLAAMLYQFIFVTLIDSPFWFMDGKIDPTDVDGDPQFHRRFQHLYERLRAGNGFGAAWLKSAVISESNPQNIYGGTVEEMDLARCNSARRKALVMQFRDELLGRRVFQLLLRPLESEAEIARRNGGLHRILEQAVYAVIYTEGGIYGNSVIYRLPDLSVFNYDSDNMVGHTYHGTSSNRTPDCAAAPGGRVLIVTRPGLTYVDIESFGQLGRRPPYRLFPAEVVVEVTKKKQASTKSRPKTKPKTTPRNKSAKPSGPDLQSNSIPETSKSASTSQAASAPEVEDNTSPSEKNEPLGKLIPPLRKSFWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVW7</accession>
    <name>A0A8G1QVW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_378659</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512561.1">
        <property type="nucleotide sequence ID" value="XM_025656306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVW7"/>
    <dbReference type="GeneID" id="37159708"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF141">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034905250" evidence="15">
        <location>
            <begin position="21"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="16">
        <location>
            <begin position="26"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="17">
        <location>
            <begin position="114"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH54639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="426" mass="47413" checksum="8AA383FE84DE2F19" modified="2022-01-19" version="1">MKIHQLLFTVLAALTVSVFAVSSNATEFPECAVSCLHQESPNCTITDASCVCTGDASKSSLVTCALSNCSALEYYITRHLYELECDQPIKKGPPLVDPSTLAPAILATIFFFIRIAAKVANLAGGWGLDDYTVTIAWILGVGLFVVNTYMIKYGFGMNTWDILPFHHVTLVFQYFEGLAMMYKIQISLCKISVLLFLLRIFQSRVFRICAYILIGINAAIGITFALVDLLRCVPVHLDWDNWTGEYEGVGTCINFIAAVLVHCLVNIFVDVVIVLLPIYEVSKLQLPWMKKITVALMFMMGLILTIIAIIRVIVFWENRWTTNLTAGLQPLIHWSVIESQIAIMTTCLPAARAFINHYVPGLPGSTQRRTYDRTNSLYHNGGASSGVTNSKISKSVNISVDYTTRSERDSTSAVHLVDMDGRYERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QW64</accession>
    <name>A0A8G1QW64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_522694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512711.1">
        <property type="nucleotide sequence ID" value="XM_025665281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QW64"/>
    <dbReference type="GeneID" id="37168683"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="33"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH54789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="225" mass="25032" checksum="459A687D90EDE07A" modified="2022-01-19" version="1">MSTTTKQPTFTTTLIPPPGPSPNPPLTVPPPTTTLTTPTDPLTTALLIRRDVFIHEQNCTPDGEIDSDDPRSWQWVVYAQHQDAETTPTPVAVIRLVPPPHAPHEILTHPETASSLPKWDLKSEPYVKLTRVAVVKEWRGYGLGRVLVDEALRWAAQNPGEIQQAFRDVAGVEGEWKGLVLVHAQVQVEGMYKRLGFETDEALGRWDEEGIEHVGMWRRVSVGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWG2</accession>
    <name>A0A8G1QWG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Swiss Army Knife RNA repair protein HAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_452633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512193.1">
        <property type="nucleotide sequence ID" value="XM_025660867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWG2"/>
    <dbReference type="GeneID" id="37164269"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018812">
        <property type="entry name" value="SAK_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF23">
        <property type="entry name" value="OB FOLD-CONTAINING PROTEIN, NUCLEIC ACID BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10307">
        <property type="entry name" value="HAD_SAK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Swiss Army Knife RNA repair protein HAD" evidence="2">
        <location>
            <begin position="62"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH54271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="565" mass="63807" checksum="066D493B44DECA1D" modified="2022-01-19" version="1">MRSAKAVVTENAAAAMRVQAHGAPARTITSLRRWSIANRELPAVSHIRSIHVYDFDNTLFLSPLPNPQLWNGPTIGFLQAYESFANGGWWHDPNLLAATGDGIDKEEPRAWEGWWNEQIVQLVKLSMEQKDALTVLLTGRGESNFSDLVRRMVDSKKLEFDLICLKPEVGPRSQRFSTTMEFKQTFLEDLVLTYDQAEEIRVYEDRVKHVKAFRDYFEQLNRRFQAPNSGRRPIGSEVIQVAEGSMYLAPVMETAEVQRMINSHNLTIRNPSLNRAKSPYGRLRIKRTIFYTGYLISNADSGRLIRQILNPMLPFGHADSNDLKYMANSILITPRPAPRSILDKVGGIGKKLSWQVTGTACFENRVWAARLTPVPATEKYYTENPHPVVVLAVRKGARPIDAGKIQNWHPVPADKALTFETVVGEKVVLRVEEENPNEGEWESQFLNKNHKRRHQQERDEEILYPDGTQDGPPHSRPHYNPRYGGNNRNHHDDGPRRGGSYRGRGRGSSQRGRGHQNRGGTRGRGRGRDAGPPGGYRSLDDYGGGYDGNHYEEKPGPGGGPVMNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX54</accession>
    <name>A0A8G1QX54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_523434</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511712.1">
        <property type="nucleotide sequence ID" value="XM_025665350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX54"/>
    <dbReference type="GeneID" id="37168752"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="61"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH53790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="394" mass="43437" checksum="4609AD5D6FAAFB8D" modified="2022-01-19" version="1">MNAGGSPHNGTGGNSTTGTPLPKPSSAVNFGPELLAAVWTMSALSIIVVAMRSFGNAKFGNFQISDIVTLLALALLVIAAALSSVAVDYGYGKTASSLELHHAMSSLKYSTISQAVVTLAATAGRLAFIIYLIELLAARKLHRIILWTLVPLQVVVNVISVFLLFFQCSTHVEELFNPSQATHCMSLKVQIDYAYFQGAFNSACDLLLAAFPIYIFWRFNWNVRVKLVLVSLLSLGVVAMAASLVKTIEYPTIMTSTNPRTNHVTLLRWMFVEAGVVLITASIPCLRPLLVHWVKKFIKRAPTLHRKMDNGEGTQSTTLNVSQMTQDWKKRWIMPYMQQTESGENLEQHILANISTHIFAGDREFLDRHVPGIVKKVEVTVVADEIPLTEVEHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY11</accession>
    <name>A0A8G1QY11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC-like ligand binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_451211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513915.1">
        <property type="nucleotide sequence ID" value="XM_025660538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QY11"/>
    <dbReference type="GeneID" id="37163940"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02223">
        <property type="entry name" value="cupin_Bh2720-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052538">
        <property type="entry name" value="Flavonoid_dioxygenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346">
        <property type="entry name" value="LIGAND BINDING DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346:SF1">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="88"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="203" mass="22450" checksum="D66F654AEB9E8AE0" modified="2022-01-19" version="1">MNGLSRCLGRQIIQHAKTPFFSNTTPLRLSGVHLRRYSDQSSKYNGNMTTQPPKNEMVYMPGVMSPSRSFGVFRKVLHTGLYSQFVAMEVPVNGEIGDEIHTVDQVLIFTHGTGKAIVAGKEQEVKQNDVVIVPAGTQHQFLNIGNTPLEVVTIYSPAEHDPRTVHQTKAEGDAQEEAGEDKAPEWSQRSKSENEKIGLVIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY79</accession>
    <name>A0A8G1QY79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_452301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512267.1">
        <property type="nucleotide sequence ID" value="XM_025660790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QY79"/>
    <dbReference type="GeneID" id="37164192"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034400651" evidence="1">
        <location>
            <begin position="21"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="105" mass="11258" checksum="0B0E7A42E6151E7F" modified="2022-01-19" version="1">MKVTATIAAVALAFAASTRAATCTPGLDYCSNVLLDVDPSNRNAISQTLQSSGGGAYANDQSSWKSLIFHCNNDHSLTWRKCDEYEECANQGSGKNDICVFDAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZQ9</accession>
    <name>A0A8G1QZQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_67951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513779.1">
        <property type="nucleotide sequence ID" value="XM_025665585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZQ9"/>
    <dbReference type="GeneID" id="37168987"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="135" mass="15948" checksum="0668ABAF6EC9ADE2" modified="2022-01-19" version="1">MESESILVILITLILCKKRKQNKKRRPRSSKQSSSQIKNQTGEVNSVTPGRPYYFFFFFFFFFFFPFSLFPFFHFPASARVPVSNSTFGTRSFGELQQDRLFPRPLGLVASYPRQLRRKESCDHKARMEKEKIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0F7</accession>
    <name>A0A8G1R0F7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_469628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514293.1">
        <property type="nucleotide sequence ID" value="XM_025662341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0F7"/>
    <dbReference type="GeneID" id="37165743"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="392" mass="42191" checksum="0FF5835240F3555D" modified="2022-01-19" version="1">MPQPTESKENLPPLHTYTIAYITALPKEQTAVLATLDTIHHYHIPTPTSDKNTYTLGTIPPHNIVLICLPTMGTTSAASAVTSLLHTFPSMRFVLLVGVAGGVPRNGVRLGDVVVSVPVSGGYGGVVGWDRGMLVGDGRVVLGQDGGGLGVKEEVGVGLGVKRVLDGLKRNSEMVARKIDGCLDDVEGRFPRLVPRWTRSDGLRDPLLERWWMYSYLNSVVWLLWKVVVAGVVGLLGLWGLAMMGFGFGFGFEAGMGKEEMVGAKEKKGGKVHVHYGLIASGNFVVKDAKARDALNKGFEEGILCVEMEAAGVMDLVPCIVVRGICDYADSGKNKDWQEYAAMVAAAYARVLLESLSPGDVDMVGDARNIHVCRGKVEYPSNPVELDMGIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0I0</accession>
    <name>A0A8G1R0I0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_450928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514199.1">
        <property type="nucleotide sequence ID" value="XM_025660485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0I0"/>
    <dbReference type="GeneID" id="37163887"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="404" mass="44337" checksum="826BF317EB490908" modified="2022-01-19" version="1">MADYWQPQSSFANPSWVQGNQSCWRSSTFRDLIHAFPKPKRTGRVMKPRSAGNSPSSAGRRRTATIPYSSPMYQGYQAPVNTAFVASALARTGQNRPTSWHPALESVSYPTTQYVPATTALDNFAAIGVCPQPLPTASATFDNSSMMSSYTTDIPCSDMGFPSLPDAPQHQMSLQQSTMLPMSESQIEPVSWDTSASTLSTMAEPMSDCYSFDMSSMHNNIPPVYVAGSSYESVPSSGCLTGPPTPDFLPIQRPDDDLHSQIESLPEKQNEDELVGMGLYSNPEASLGNSLLGLSGKGLKLEETFTPSSDNEAEDQDDEDDQEDEDDDDEQNQDESPVNNKGTDSNPKQPEAETFQQPIKAPGNMMQRSFFFDDDDLEQHAVVDSQPFINMASQPCMNYGYGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0N1</accession>
    <name>A0A8G1R0N1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_450496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514398.1">
        <property type="nucleotide sequence ID" value="XM_025660386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0N1"/>
    <dbReference type="GeneID" id="37163788"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH56476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="257" mass="28963" checksum="BEFB7134767D4315" modified="2022-01-19" version="1">MSKTSIYTPCLISLILTTLFLTTITILLLTPPTFLPHIIPPICPSQSLSLPDQTHGRVFNERPELERTVNDSDEVQTWESILLPPGGGGILSHTIPDRIHLTADEKKEKKLLSWGISMFHQLHCLIVLRAIVFPETTENKINSTSQAHSGNMMHDKVHWAHCFDYIAQGILCAADDTIERPRKTKDWHGKTIFDIDGVGAVHQCRDARVLWQASVKSMEEPVDMQGWREGMGVRAFLGERKMGDDEKVPELYSLGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0S0</accession>
    <name>A0A8G1R0S0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carboxylic acid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_49367</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514334.1">
        <property type="nucleotide sequence ID" value="XM_025663839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0S0"/>
    <dbReference type="GeneID" id="37167241"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000395">
        <property type="entry name" value="Carboxylic acid transporter protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000465">
        <property type="entry name" value="Carboxylic acid transporter protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF9">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORT PROTEIN (AFU_ORTHOLOGUE AFUA_2G09450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="69"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH56412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="509" mass="55285" checksum="C3C4295C20F1CA25" modified="2022-01-19" version="1">MSTANEPAEPPADGILATAKQAWGDLFKWKQRVVVTNEHGETHTEWQAPDRLQNPISMMLQLSARDWLFFIVGLIAWTADAFDFHALSIQTVKLSKYYGRSKTDVTTAITLTLLLRSVGAAFFGLAGDKFGRKWPMVLNMIVLGVLQIATIYSHTFQQFLAVRSLFGLFMGGVYGNAIAMALEHCPVSARGLMSGILQQGYSLGYVLAACANLGVGGATDSWKTVFWIAAGISLGVGVIRIFFPESKQFIEAKKAGRVSSDPGAFWRETKQMLAQEWKMCVYCVILMTWFNYYSHTSQDSYTTFMLTQKDLNNAAASRASILMKTGACVGGTIIGYLSQFFGRRRAIIVSAIISGILIPAWILPEGERALSVTGFFIQFFIQGAWGVIPIHLNELSPPAFRSSFPGITYQVGNMISSPSAQIVNAIAEKTFVTSSSGKPAPAYGPVMGVATAIIATGIAVTTAFGPEKRGRRFETAVAGAQDADTATLQKEVKLEEGLKGDIEEKVGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0Y3</accession>
    <name>A0A8G1R0Y3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_488806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514548.1">
        <property type="nucleotide sequence ID" value="XM_025663560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0Y3"/>
    <dbReference type="GeneID" id="37166962"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="319" mass="35509" checksum="505A978B1B57583D" modified="2022-01-19" version="1">MSSQSKEYADLMGRETSFGTFLFIPQWFSTLRLGSVGYFDRTGEWNEITNLLEKGQAEKDGFKPFSHDLKLRDVRETHWQAGSAETETGRSSRLTTEASGAIAAAPVEASVQVKTSSSTTGSAALITSSVVRNYRFQGDFKGPIKGWVEDNAKALVERRSDIETQGLWAVMGAWVTDECAIKMTSGKNQEIDVSFDLGATGIGKLGAGAGAFDKLKREGWWTYPKNEKSQGYVVSFAGVEYSLRSLHKLRSTPLKLYNETISLPPKRNQPGSAENEHRMALLLKLAQLQQIENKEEKEAELKRLAEEYPEIHDLRSKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1Q2</accession>
    <name>A0A8G1R1Q2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AT DNA binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_374225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514814.1">
        <property type="nucleotide sequence ID" value="XM_025656117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1Q2"/>
    <dbReference type="GeneID" id="37159519"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="37787" checksum="A7286FC988A602EE" modified="2022-01-19" version="1">MSNQPERPWTEEEKYTLLTEILKKARVPSSHLVRMIRDFNITPSWADIPLPPGRSLNSCQIAFCNMLQHVQLSVTHSLGSIPPQPHEPSVPATVPLESSSVLRKRPLIPSDRTIRAPRAIQPRPATSTASYSSESGASALLSPSSESVTARGEPPRKRGRPSKAESERRKAAAEARGETYPPPRRSGSHKLKVSSTPTSPSGVAPGLPSFSPQASSSRPPELPRHEMHYVPPPGRPIPLMGPSSDERPRDMPNQDIGSSMRELPRPDLRQTLPSPGTLHLGHRDTPLIRREPGMPFEPLPPDRHPFSQSNRRSLIHPTSRYPDEPPTPASDLPISKPPENRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1R3</accession>
    <name>A0A8G1R1R3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_398163</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514938.1">
        <property type="nucleotide sequence ID" value="XM_025657049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1R3"/>
    <dbReference type="GeneID" id="37160451"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000067">
        <property type="entry name" value="Transmembrane domain transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="610"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="656"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="679"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="712"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="353"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH57016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="750" mass="81651" checksum="52F3B82073ADA25C" modified="2022-01-19" version="1">MSSSRMSDNGEGSSSQRNRSASPISTSAMRSGSPAGDVSSSYRHASIARLASPIPSPSNSYSSRQVPLPIQPTAATNQDLRKVDNPSSLPGPGQSMIASALQDYLGRSPSPRAGTPPRRTASPGLLHQPVRSNYGSFDNKAGREGSIYSAGPYEDPEVVKRHLVQPQNVVENRDIHSSGGAQSNAEDEFSSLQLQGGDITRQVYRWAEDAEAGSSLRKPHRSRSFSHARPAPEDETTNINSIRVPGGFRRDYLRRAVGPNLPGDLDGSGAQASAAQPQLPTSSFLEFLTLYGHFAGEELEEDDEVLGPDEYFSSDTYDEAEGREPGEDSALLRPDTAGRRKRKPRGGTGTNTRTGAALLLLKSFVGTGVLFLPRAFLNGGMLFSSMVLLGVSLLSFYCFILLVNTRLKIDGSFGDIGGALYGKHMRRIILGSIVLSQLGFVSAYIVFTAENLQAFVLAVSKCKSFIDIKFMVLLQLVIFLPLSLIRDISKLGFTALIADLFIMMGLVYLFYYDFLTISNQGGVSDIISFNPSTWTLFIGTAIFTYEGIGLIIPIQESMKHPQKFPGVLAMVMVIITIIFLSAGAFSYAAYGSATKTVVILNMPQDDKFVNAVQFLYSLAILLSTPLQLFPAIRILENELFTRSGKYNPSIKWKKNCFRFFLVMICAFIAWGGAEDLDKFVSLVGSFACVPLIYVYPPLLHLKACAQSRRQQIADIALSVFGVLSCLYTTALTLNNWINGSDVKAPGYCDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1T4</accession>
    <name>A0A8G1R1T4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_459073</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515771.1">
        <property type="nucleotide sequence ID" value="XM_025661625.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37165027"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000031">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000400">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001280">
        <property type="entry name" value="Related to 6-phosphofructo-2-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000835">
        <property type="entry name" value="RNA polymerase II Elongator subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 13" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="15">
        <location>
            <begin position="45"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="629"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="680"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="783"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="869"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="1191"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="1239"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="498"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1089"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1098"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH57849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1381" mass="153609" checksum="5A0C8F7A6CE9BE6F" modified="2022-01-19" version="1">MDTLLTADIVANSPRFRRKSSTFVDAIHDLPEKADLAPAQLYSTESGRLFHSGRIVIITVGLPARGKTHMSVALARYLRWLGVKTRIFHLGDYRRATIPYGQDIPDDYFFVNASASSVLLRQKIVKRCREDIYHFLNHENGQIAIYDAVNPIASGRRSLAKEFSKHDIETLFIESWCDDERIIEENVRRVKISSPDYVGWSSEDAVKHYLTRIAARIPQFQTMEETDLNYIKMINAGERLIVNNKSFGYLSNRIVFYLLNLHIKSRHTYFARAGVSLEAGSYKADASLSEQGEEYAKKMTECLLQHREAERQAMADQGEKDYELKPLTVWTSTRRRTVETAKYLHEKGYKVRQRSQMSQLNPGVCEMMSERKIRQEYPDEVAKHDLDPYHHRYPRAESYHDLAVRLEPIILELEREQNDLLIIAHESVLRVLYGYLMACNAADIPFLEFPRDEIIEIIPESYQNEARRIHIPGLPKEIIPGSPEDIKIPVPPSGMMTPLAGGLGSPKEGLATPQSGLRTPREPERISQQHARIGDGGVDKRRGPDFSQLIDKPPSLPAQKVGWLCDPFEHTWLLFMVSITTEYISVGGNRHPAAADWDVQSGVLAFGADNNVALWDPRESSQRGVYSLLVGHTDKVSVVRFYTCPSTGARLLLTGSVDHTVRLWRPDSENSRQFVHAHTLEGHTASVNTIAIAEGLDIVASGAADATVKIWKISTQGEPKGELLRSIPMKPRFFPLALALTPLRTESNDRPVALAVAGTTNIVQVYVAENTLVDPQFKLAAVLSGHEAWVRSLSFTSDKQSKTGDLLLASASQDKYVRLWRFQRGEVTQATPACDDDPMLGGFEPTLSNKAHQFTAAGTKYSVTFEALLFGNEDWIYTTAWNPDPERQQLLTASADNTLTIWEQDPVSGVWLSAERMGEISVQKGSTTATGSTGGFWIGLWAPDGKQVVSLGRTGSWRSWKYDAETDMWAQSLGISGHVRSANGVLWEPTGGYLLSTSADQTTRLHAQWLRDGLKSWHEFSRPQIHGYDLNCVDTLGPARFVSGAEEKLLRVFNEPGPIAQLLEKLSGFKQTTEGALPDTAQIPVLGLSNQAPADDAPTGEDGVEGEEVGKAQANQALLAESNQPPLEDQLARYTLWPEHEKLYGHGYEISAVAVSHDRTLIATACKASSIDHAVVRLYDTSDWHEIRPSLAAHTLTITSLAFSSDDQYLLSVGRDRQWAVYQRSEQDPSTFSLLTSNPKGHSRMILDAAWAPASGKPIFATAGRDKSVKLWQMTEGSFECKSTIPLTTPVTALAFLPQIFNNSFFVATGEESGAVSVYQVAVDSLEASHLSSINKLSSPSKVITQLSWRPVPDADTRNFALAVASEDTSTRIYSFSDMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1Z4</accession>
    <name>A0A8G1R1Z4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_31164</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514949.1">
        <property type="nucleotide sequence ID" value="XM_025655417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1Z4"/>
    <dbReference type="GeneID" id="37158819"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH57027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="247" mass="27894" checksum="0206703F00309923" modified="2022-01-19" version="1">MLLNAKTAISTSTVLLVPYSKWHVPRYHEWMKDEEIQEATASEPLSIEEEYAMQQSWRQDPDKLTFIVCLPSSSQGETSTPTIKDTDDAPDRMVGDINLFLRVDDGEEGDAEPQIIGEIELMIAEKNNQRKGFGKAALNTFLRYIVDHEAEILEEFVSRDETAAKAMKGVEAVPKFACLSVKIGQANERSLALFEGAMFKKVTEEPNYFGEFELRREREALGRDMVDVSLERAGVSGYVEVGYERVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R288</accession>
    <name>A0A8G1R288_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cysteine synthase 2</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cysteine synthase-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">O-acetylserine (thiol)-lyase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine sulfhydrylase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_439574</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 21">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514382.1">
        <property type="nucleotide sequence ID" value="XM_025658719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R288"/>
    <dbReference type="GeneID" id="37162121"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000049">
        <property type="entry name" value="Cysteine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="18">
        <location>
            <begin position="70"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH56460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="444" mass="47615" checksum="FEF05CC8EB5A3D9B" modified="2022-01-19" version="1">MDDRSHLYIGTAFVAGVLLTLGFKDLVYPEIERRVKDYYQASSQAKKAATTSEDALSARPGPPAIVEGIEGCIGNTPLFRIKSLSDATGCEILGKAEFLNGAGQSSKDRVALSMIQIAEEHGILRPHSGDTIYEGTSGSTGISLATLARAKGYLAHMFVSHSPTHFATTPLQALILTICSSCMPSDQAIEKSNLLLKLGAIVDRVPPAPIVEKDNFVNRARALAQAQTASNTDGRGFFADQFENESNWRAHFNGTGPEIYAQCEGKLDAFVAGAGTGGTISGVALFLKPKIPNLHVVLADPQGSGLYNRVRFGVMFDYKEREGTRRRRQVDTIVEGIGINRVTANFEAGKELVNDAVRVTDAQALAMARWLVEKDGIFIGSSSAVNCFAAVKTAMKLGPGHRIVTVLSDSGSRHLSRFWAKAGDVGGAVDTKLEDVLNAKEEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3A8</accession>
    <name>A0A8G1R3A8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_519337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516380.1">
        <property type="nucleotide sequence ID" value="XM_025665042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3A8"/>
    <dbReference type="GeneID" id="37168444"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="599" mass="69812" checksum="57A3463DFFDF5871" modified="2022-01-19" version="1">MEARIGSDNGTGPSAPTYGLPHLIDEKQEDKYPLLLVYLAKQTPAEQAYLASRLQEFFRRENITLTRWQPSSGLLRRVALHGSCPDSQANIHAMAVLAYRAGWTRFIVADGLTQRQVHGNLRMWEDPLLSLVMVVVKPEPVVLAPTGDFCVFAKRAAVDGFSKDFLEKLSNLQPPKRSLMHNIERDRYDDPGLTLYDPDRPPFTADRATSLSHEERFSITAAFLTKHTPLPPELAEQVLDWLSIANESPMWLPPWIYHKEKHLNIFLLFPATQHELHHIQTLFQNVIEDYRKIERAGVRSYTMTFIPWEYHRTRSRRDLANLWEAYRIRTGDKLAPFNIYFLQQMPVAQNVNDLELGIVKYERGDLPNVARITLENIILDRGPWIEMMRRRGLSAEQYMYSHKVDPELLRPFDQPFYPNPPRWLPAKKGQYTIPVFYLTKDLSRSEKYEIEKEIRTLGQVEESHWGSKVACYVPWDGEADGTLDDVWKIFWEVFTYHGERDNHFPIFFIDSQSARDDTVLVVHPDHLWFDQSNHRALAMLQNVIYPSVRGLQYGRVRGREAHTMHSNVSIGNMFFEEYTRPQRFPRPDWPCHGFRAAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3B2</accession>
    <name>A0A8G1R3B2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_512000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517198.1">
        <property type="nucleotide sequence ID" value="XM_025664630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3B2"/>
    <dbReference type="GeneID" id="37168032"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH59276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="418" mass="47299" checksum="3E6FACD9BD9BCFB0" modified="2022-01-19" version="1">MADSDLETRKLGVWGLFKEVFNWYPSNYPTNERKYVVPLGLTTGYSSSRLLFKLDLSILVFACLCFFVKYLDQTNISNAYVSGLKEDFSLNGNQLNYFNVCYYTAYVVFQVPGLLLMSRPILARWLLPSLEILWGICTFAQSRVTNVSQLYALRFLVGMFEAPVFAGTHFILGSWYSGPELFKRAGTWFICNALGTMVSGYLQSAAYTNLSGVGGMPGWKWLFIIDGIFTIPVAIIGFLVFPGIPDSPRPFFLSEDDITLAKDRARRANIRRPGRMTLDVFKRTLKRWHIWVFILCYACMIMSSYPTSYMNLWLEAEGYSVPQVNKLPTVTYAINIVASWLGTTLAAIYPSWLIYTIASACCLFSSLCMIIWNIPKALKFVAWYLFGAAGCTSPILYSTVNTIVKDDSEERALIMVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3W9</accession>
    <name>A0A8G1R3W9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional activator of proteases prtT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Zn(2)-C6 zinc finger-containing protein prtT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_487849</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the prtT family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515954.1">
        <property type="nucleotide sequence ID" value="XM_025663483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3W9"/>
    <dbReference type="GeneID" id="37166885"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000011">
        <property type="entry name" value="Transcriptional activator of proteases prtT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR OF PROTEASES PRTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="12">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH58032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="624" mass="70229" checksum="798B1C5DE0454214" modified="2022-01-19" version="1">MTRTVDEIKYETPSSWEHKSLDVAEDGRRLAPHSDTARPKGRIRRSMTACHTCRKLKTRCDLDPRGHACRRCLSLRIDCKLPETTDRFQDSAAIWPDATSAIPSIEERLTSLERSMREMTGMMRQMLDHSPGFANTSIPHLTRSIMTDDTASMEGSPSSPFLPKPVRLIQDLQSDFFGEAETTSPVDSPLSSDGAAKGAIDSKLSLKLLQTFVDHFGACVSIYNLSDIHNDMKAPDSLLYNTACLLASRYVPGIPASAVHALYLQVRHAVVNILWEKPPLKYETLQALALLCLWPATAQKEPPMDSWLLSGISINHAIIALEFINYAPSEVVVDNETAAQLRLWNTYCLTQLHFAVGNARPFHIQQRYLDHCPRILEHPAATLEDARVVAEIQLYLITLRLQSNSSRMRLADLDYEEIERWKREWAHLFSGESSTLELSLWFCQTLLHRTAMRLQPRSDRLASEVLQTSRLIISRFLQIRYSTALSLVDQVYFIVGYAALNLCDFNLMDPLIEQVQMFLLHLAPNEDHIAYRFSCMVAEFKRRCSSAECNDPSSTVKGSPLSSYGDSRKMSMGQAPFMPPLMDGMIEGYGFEQLMPEVMPSSFPDGILNGMPVTGLAAYRSATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3Y5</accession>
    <name>A0A8G1R3Y5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Monosaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_448065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517050.1">
        <property type="nucleotide sequence ID" value="XM_025659857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3Y5"/>
    <dbReference type="GeneID" id="37163259"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000180">
        <property type="entry name" value="MFS monosaccharide transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF6">
        <property type="entry name" value="MSTA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="22"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH59128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="530" mass="58089" checksum="9F66685C24349DA7" modified="2022-01-19" version="1">MADGFVDASRVEAPVTLKTYLMCAFAAFGGIFFGYDSGYISGVMGMRYFIEEFEGLDYNTTPTDSFVLPSWKKSLITSILSAGTFFGALIAGDLADWFGRRTTIVSGCVVFVVGVVLQTASTSLGLLVAGRLIAGFGVGFVSAIIILYMSEIAPRKVRGAIVSGYQFCITIGLMLASCVDYGTENRLDSGSYRIPIGLQLAWAIILGGGLLCLPESPRYFVRKGNLAKAAEVLARVRGQPQDSDYIKDELAEIVANHEYEMQVIPEGGYFVSWMNCFRGSLFSPNSNLRRTVLGTSLQMMQQWTGVNFVFYFGTTFFQSLGTIDDPFLISMITTIVNVCSTPVSFYTIEKFGRRSLLLWGALGMVICQFIVAIVGTVDGSNKHAVSAEISFICIYIFFFASTWGPGAWVVIGEIFPLPIRSRGVALSTASNWLWNCIIAVITPYMVDKDKGDLKAKVFFIWGSLCACAFVYTYFLIPETKGLTLEQVDKMMEETTPRTSAKWRPHGTFTAEMGLTANAVAEKATAVHQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R448</accession>
    <name>A0A8G1R448_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_519223</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516243.1">
        <property type="nucleotide sequence ID" value="XM_025665031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R448"/>
    <dbReference type="GeneID" id="37168433"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="143"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH58321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="438" mass="48597" checksum="462A1F39899D1A6A" modified="2022-01-19" version="1">MPAKSRFTRLDAFAKTVEDARVRTTSGGVITIASLLVILWLVWGEWVDYRRVVVMPELVVDKSRGEKMEIHLNITFPRLPCELLTLDVMDVSGEQQTGVVHGINKVRLTSAAEGGRVIDVKALELHSKDESAKHLDPDYCGECYGATAPAGASKPGCCNTCDEVREAYAQQQWAFGKGENVEQCELEGYAERIDAQRREGCRLEGVLRVNKVVGNFHIAPGRSFTSGNMHVHDLATFFDAELPESERHTMTHEIHQLRFGPQLPDELSDRWQWTDHHHTNPLDNTKQETNEPGYNYMYFVKVVSTSYLPLGWDPLFSSSIHSAYDQAPLGSHGIAYGAEGSIETHQYSVTSHKRSLMGGDASDEGHKERLHAANGIPGVFVNYDISPMKVINREARPKTFTGFLTGVCAIIGGTLTVAAALDRGLYEGVSRMKKLHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4G4</accession>
    <name>A0A8G1R4G4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_253191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517828.1">
        <property type="nucleotide sequence ID" value="XM_025654952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4G4"/>
    <dbReference type="GeneID" id="37158354"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052779">
        <property type="entry name" value="WDR62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589:SF1">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="867"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="882"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="909"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1015" mass="109747" checksum="114A01F9942D333D" modified="2022-01-19" version="1">MTTNSLSAKSRPASSLRITPSNSPILRPPTRSSIHKAPSHQTALSLRTVLGTTTTTPHGFSNHEQSRSFALCAGSVAVLVELDDKDCVNQRFFRARPSAASVNPVTSFYHQSTPPTTPDSRAKFSSSLRSTAHSNAYNGSPCHDTADPGSPRGWSSRERVKAVTCTAISPNGEFLAVGETGYSPRIMIFSTAKDTSSEIPLSILTEHTFGVRGLAFSPDSQYLATLGDVNDGFLFVWTINPKSGSAKLHSTNKCTSHVRDMCWMGQTLITVGVRHVKVWRLPDARPGSPRSRLTVEVPSSSPSQIPKAFSGRNCLLGSLAESTFSSVASFSDRESVVGTDTGALCLVDDSEGSQKLSVVQYLDFGITSLAVDWHRSCVWVGGRGGQIQSFSFEKIRSSAAPLSPTLSGRSSAEQALKGPAIICIGSLGSRVVAVDATNAIEIHPGDELGDEVDQRTPQTMVSAHRDAVLGIRGLKTPNQYEATFFTWSRKGSVKFWDSRGKCKDSRAIVLEHPPGCDEDISNELKVVRATDEIDLFVSGDKFGVLRMLLGSSWEPLHEVRAHGGEITDIALHTTPDTCLIASCGRDRMVQLFERSNNKFELIQTMDDHVGAVNQLLFLDNGEKLLSSSADRTILIRDRVSREVNGTPIVAYLITRVITMKASPVSMTLSTDTDVLVVSTADRCIQQYDLTTGRQITSFRAIDSDGNDTVVMNSLTVTSDISKQSFSKLLFGVSTTDKSIRVYDLERGVLLSAEFGHTEGMSDACLLANQSNDSTQSDDRILISSGLDGLVMIWGVSVLPQSSSEPLPVLHKDDDAPVKELTLAKPPLRKVLSKTELAGLQRQENIAVTPTPARGHSPTFLRKLSKFSLSPAKHGNTPPPTTPSATSNRRSPTSSACRDKSHPTSPSLHTSKTASARKAGSSRGESRRSSLDIRARARLSGKSDFGSLNTSTEQVCRTLKAYRKKLNGSVGNIHAQKELERELNLTLRALNLRSNSSESAETETESSGKENEKALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4K6</accession>
    <name>A0A8G1R4K6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_469402</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514632.1">
        <property type="nucleotide sequence ID" value="XM_025662329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4K6"/>
    <dbReference type="GeneID" id="37165731"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="721"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH56710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="770" mass="88437" checksum="BD627C939C05A4CD" modified="2022-01-19" version="1">MVNIQNKPQTTKAVSEKVVDTPAVLFIPSNVENKGGCSSKTLKKFHCILGDRFGRDRKFYPNTKDENGMTPLHYAAQLLPSGDDFWGEPVEEQQMWQSLLRGLHKDDLNEQDDDGRTPMSYAAVAGDAWVVNKLFEAGADPYQSDKNGRSPLSWAAQCGGKEIIKLLSWNIRYFNDKDNRGWTPFHYFLQREPEPTEEYDLGVVPLIWDKRHSREVEYSHWRKAVENPYVHSRVPADYMSTSLLSEPDAFGITFLSRAVQLDRILIIAILLTIEDIDIGMPDRDGKTPLWRAIEAGNRAIAELLWKYDDVTLRLLSTGAHARSEHLDWLTAFHIMLDIPNIGVMEHHLQQAIVAQVPDLPMDTVEAPTNVSSLFLEKADRRGLTPLALAKEKRLLPIVKLFLRWRAKVDCFKHKADWFNLLPDSKNMASFCNMEETYRNVSFELVRKKNNILVFDFYQAEDVTPQGHLVERCDMLQHLCYSYSRVHLDTKLSEITCVLTAEFPKPDAGFFKRHSPFHSQGIASHKCWCISWTRPQFVNTNGDVQPVFYSSTISHGQIPASDDKFLQQYIGELFQEWSLICDEIETHVIDHCNGDETSATVLITDLADDSRYLATIQKALQDQVKGIQKAISDYRRVDVYHSLRLQEAEEGFGQLKATITDRLDKQHERVRDLRQMEFARLSVEETVFMRRISLITFIFLPLMFASSLFGMNVNALQSNPDWRWYIVFGAASLLLTYALWKVSDQNIRISQIWSELRAGRAMKNKTKDCEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R510</accession>
    <name>A0A8G1R510_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_448246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517234.1">
        <property type="nucleotide sequence ID" value="XM_025659890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R510"/>
    <dbReference type="GeneID" id="37163292"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="283" mass="31617" checksum="E031B9DD5B67B295" modified="2022-01-19" version="1">MHQRTYTYVLAPRWDFRPDGPIALGNIIVDPFRPHRVLTRPDPDIPTAPIETVVETDWSLHHQRENGVKSSIWTHFLNAMGVDLGFEGSRSLDADYTVDSLTTSYFRDEPSHEEIIRRTQDGKIRDLMRLDSVFSKPVYMITGVKIAKGFRVSESRSSSKEANAGGKAGTAGTVIGDVSVGTDNQIYSKESDKHQGKTENDIVFAFQLMKIVPKGWKHKSFDVQDFYPKAALLLGDEEEETETELDVSYATAADFADSDLDIQFNMTELDDSQGAFKCVSAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R534</accession>
    <name>A0A8G1R534_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucooligosaccharide oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_457814</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517650.1">
        <property type="nucleotide sequence ID" value="XM_025661544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R534"/>
    <dbReference type="GeneID" id="37164946"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF17">
        <property type="entry name" value="OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034971107" evidence="5">
        <location>
            <begin position="22"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="62"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH59728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="491" mass="52869" checksum="AD36289EF0008B16" modified="2022-01-19" version="1">MAFSFLRVISSLLLVLQLSTAASTSTLRQCLLTAVQNDPTLVAVDGDLLYQTLAVQVYNLNWPVTPAAVAFPKSTQQVSSIVNCAASLGYKVQAKSGGHSYGNYGLGGTNGAISINLKNMKSFSMNYTNYQATFGAGMLNGELDDYLHNAGGRAIAHGTSPQIGVGGHATIGGLGPAARQYGMELDHVLEAEVVLANGTVVRASSTQNSDLLFAIKGAGASFGVVTEFVFRTEPEPGSAVQYSFTFGLGSTSSRADLFKKWQSFISQPDLTRKFASICTILDHVLVISGTFFGTKAEYDALGLENQFPGHTNSTVIVFTDWLGLVAQWAEQSILDLTGGIPADFYSRCLSFTEKTPIPSTGVDQLFEYLDSADTGALLWFVIFDLEGGAINDVPMDATGYAHRDTLFWLQSYAITLGSVSQTTYDFLDHVNEIIRNNTPGLGNGVYPGYVDPRLENAREAYWGSNLPRLMQIKSLYDPSDLFHNPQGVLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R541</accession>
    <name>A0A8G1R541_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_415399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518173.1">
        <property type="nucleotide sequence ID" value="XM_025657688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R541"/>
    <dbReference type="GeneID" id="37161090"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000031">
        <property type="entry name" value="BZIP transcription factor (MeaB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37616:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37616">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 60-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="312"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="615" mass="66895" checksum="EB4EA7CE622A2EC3" modified="2022-01-19" version="1">MATLAEHPAVAPSTFDQDIESFLDLDQLAYTSAEPARAKTALAAQPTLPSTEFNAGDVRSAGFASTTSQQAPIAFQGPSHQYDEHKQQTGLPPGALAHAMTFNNHMNGMGYGAPSPGFPMGGDLYPSSQLKREEPSMDFNSPPTRNTSDMDLESDNMGSVPGYFISPNPSTKSQFVDPNALGGHEMASMGPSTQVGRMYPGMHQQQAAMAKAAQQQKHNEYLRQQHLQQQRRMDEHMHHNAGPHSQTPRPSNPAVEERISRLLQQMRQSALNSPDDSPSPPSLLPQMAKAKKEEQDMDEDERLLASEEGKKLSSKERRQLRNKVSARAFRSRRKEYIGQLESEVAAKTNEAHELRLQNRSLFEENARLTDLARMLLSSPHFSSFLDEMGPNGLPLPSQVQSQPHPQHHQHPQHPQQAQPQQQPPQQQAPAMTQPPMQQAPPVGMVMVPNQGLDVSAMGMNNGGWNSGIDMNYGNPSVFAVLEVPEPAIDTEALSGKTSSIVDSCLPSVASSKDEAPVLTSMPAVAETEQKSDVGVENPDVVMDESDPAFALFADMPAAPTSQGSACAFDGIATGKSTFELVVEGEVKDSAQQFAHLCHSMEAAFERVSMMTAHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5Q5</accession>
    <name>A0A8G1R5Q5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_365859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518503.1">
        <property type="nucleotide sequence ID" value="XM_025655758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5Q5"/>
    <dbReference type="GeneID" id="37159160"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF3">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="287" mass="31411" checksum="9E4E0012D5BEA2BB" modified="2022-01-19" version="1">MSTKMRPPSKEDRNSNDAPGQKQDPIERRRLQNRLSQRNHRRKIRDRIAKLQERVIASELRAAASLNGWDHPSTLTPSPVDRMPPIFDTEGHPSSPIQDASSTLGSTYFPQSRVVCSSCNSALGSIPVLSSQPSFPSVYDTPNDLEATSPSSALRNSAYYPRSNPITPEIQNMNNIYPSLDSNLPLTEQWNGTAQYPGSSFYYIATEASLPHIMQAINSGSSRPKAIIVLSPNNYPPGLPAPLPTSQSSPPGGSAVELPASSSPLARERRHPLFVQYTKCSLETICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5T4</accession>
    <name>A0A8G1R5T4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_509536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518548.1">
        <property type="nucleotide sequence ID" value="XM_025664499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5T4"/>
    <dbReference type="GeneID" id="37167901"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="585" mass="66944" checksum="49A1B63F48F6CF46" modified="2022-01-19" version="1">MRTTEILFKKVRVEPATDLEMSNGISTHTPSHDSQLNPYSGFSELANEYREFVQRLAGQWPGLSYLDAYLQDPQYLQRQTFGIVLVKPSNVPPVQRDLKLDEVLPELDDGSSPILIVLEDPTPRMVAELGGQLRIDPQFWADFLVGPSWFGSGKVDIGPGEPSVQYRDDSLLEQLWPLPRPARQQEHFCFRFVARREPTPGSSEVCVGANMDGYSSLSTFYPICGDAKPGPPICANSIGLRNNLTVWENQHARKRAKGETETPSRDIPWIGVIVVKNQSSRIPVCEPGFSYIFREFLPRPRFVEHFVMDNLEISKEWEGRPQRAPKSNYSIKEILWYHLTCHLEKDDFRNAALTSPSLLFVDVLQLIGCFWVAEIESKHLQLSWMEVYYQKEVIIRRRKFPSLLDPLYPDPNGSLSARLQADLIGLHSDLIKIEPYEQFIHEAEEYCKAREQLTGLPDYSDLANDFAYLQKAVCRLNKRVKRIMGFLKSIEDDFEKSRSRYRNMLLLILALWAWLVSPVSVTASIMNLGESRESSAVKVGDVQVFWKVVVPLGVGVVLLVVSLLWITEFFTLKATRKASRSRRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5V7</accession>
    <name>A0A8G1R5V7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_485277</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518040.1">
        <property type="nucleotide sequence ID" value="XM_025663317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5V7"/>
    <dbReference type="GeneID" id="37166719"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034082019" description="CFEM domain-containing protein" evidence="16">
        <location>
            <begin position="19"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="74"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH60118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="248" mass="25422" checksum="06DC070E896DA4AD" modified="2022-01-19" version="1">MKLTISLLLLGAVSAVNGLSECILNCQAEAAASDCSTSNYNQTSCYCNNGNFPIDVQSCLEKSCSDDIGSFHTYRGSQCGGSSATTTATAAASTSTITLSSCILECQSTAADTVGGVCSSSNYNNTACYCDSDSFATQTQDCIFSDCAGQDGTFHQWRGSICASSTTTSSSTSAATSTSSSSGSSGLSKGAIAGISVGSAVAGIAIISLIVFTLLRRRWKSAHTYNEDSDPRNFPLHKMASAETTSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6S1</accession>
    <name>A0A8G1R6S1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA (cytosine-5)-methyltransferase 1 replication foci domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_448765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516662.1">
        <property type="nucleotide sequence ID" value="XM_025660010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6S1"/>
    <dbReference type="GeneID" id="37163412"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="67084" checksum="416466A6EE2CAFD4" modified="2022-01-19" version="1">MTSREDSVLAARDPSLTDENDWEEFSLSEVRVLVPGKSRYANLLTASPENPVQVTGCLDEVEEEQEKLVLDPEYLTKRIVLENVTHFAYGQHNDGEVGFWVAGKAGWFSISPAKGYKAIFNDVVEAIDLLYFLADRHQSKRRRKRRNWNPSVEYLCEEYVSHTHGICEDADDSAEVFYKHHEFLLSRMLKGEEDVQWTTTCIFEHLCEKFPDDYEQIKAQYEGAKEVESEEEEEDEQEEDKEEDENEDQDEAEAQPDTSGLSKDQADAIYKVILDLKEAGYLAKRQLTFELLINTLIERFAIDSTDYAHDLVGARAEAIIEMMDEAKTYNFDWSRKVIYRELKAAAKKNRVQQITLTPLRPRPTEDDESSGEESEHEDHPRLRRRRVHKSVLRPKSSVATKQTGKRTRSAVDDQDDDSDDNEDAMDEFETPSKVRGHDLVRDPLSTRAKRRTRSLLYDATPIQKTPLQETLQSRNTSVSGADRETNADASDLEGSHEDDITSDTWTCHVRGCEKVIHKSNSKRGKELIQDHALAHADDTKAKIDLVFAEQRLNIGLPVDNLLSRIRELGAFDTEHPVDGAFTNGVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6W0</accession>
    <name>A0A8G1R6W0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyrroline-5-carboxylate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_487507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516722.1">
        <property type="nucleotide sequence ID" value="XM_025663459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6W0"/>
    <dbReference type="GeneID" id="37166861"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF21">
        <property type="entry name" value="HYPOTHETICAL PYRROLINE-5-CARBOXYLATE REDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="5">
        <location>
            <begin position="15"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="6">
        <location>
            <begin position="189"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="18"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH58800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="292" mass="31050" checksum="54EDDC022A829F8A" modified="2022-01-19" version="1">MAVQSLSPERREKTLAFIGCGNMGSAILSGLLDATRTQAGKFNHFIISTKTAASAERLRTQYAEDASRVTIAHDSNLRAMREADITLLACKPFLAKGILSAPGVGEALSGKLVISIMAGMTPTDILDCLGDGDRESVKVLRAMPNVAARLRQSMTIVELPERKPLEEELVEIVTWVFEVIGKVKLLSADLFDVGTMLVGAGIGILTVPLEGLLDGCVVEGLRRAEALEMAAQTLSGMAALLKEGSHPAVLRENISSPRGCTIQGVMTVERAGARATFADAVINGTRHLKGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7K0</accession>
    <name>A0A8G1R7K0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_417621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517874.1">
        <property type="nucleotide sequence ID" value="XM_025657779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7K0"/>
    <dbReference type="GeneID" id="37161181"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="660" mass="75858" checksum="A8E4B6BD7A76E181" modified="2022-01-19" version="1">MARDELCGRTCSIPKEKRTNSCYIFRLVHTDIFLVTIYLRYGVNYDTDSQGICLQKLQDCAVWRSPSDDYRRIWWDPGQKMQNRFCEERRNLRWLPTWFKSYSYIAADTIWNPGPPPRHSNTTTSDVCSGYASLRAMTGALSRSHTPRSITSRTIYYALGGSNVTSSYSQLFFQRGYQRASTRGKARQSRQYRTECTREYRFQREHLKYASKKDILQRQSRHTSCSTLMRLGFAGRGTGDIRSLSLPCLFSQNYESSIASHAPHCAKASFPEGRMKTMKRLREFRKHQVWSARMSLQPSNYTKLLGPPAGTPRFGLSATSSSDQTPLLILTQSRRKEALSTKSSTLIPNNSSKHNHVKNVEAAGCVNHIAGLAVQYSAAPACGRSSLPCRLEARHRTGLGLEEERNIDCCTRQKEPLCIYRSRTKESRERRKQKLTGLLVENVPISELSSWELQFIDGLDRRLEWLYNQLCPGRRPYHFALLANHWLNKETWLVIDPPTRISIDARRRLGDPRFNLPYPKPDWSAKPKYPRVPRKAVYTPRINSWRLAVNKHRKASGLRDLVKTIRFYPDSTDDPPDGKVDPSCWMLRRPPQGPFMSARQGNVYYEGGAGWQETFDDWQKIGHGHLIRKATHEGRVNRTRAKEVAGAISRYFHMATAKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7V5</accession>
    <name>A0A8G1R7V5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">General stress response phospho protein phosphatase Psr1/2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_273381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516282.1">
        <property type="nucleotide sequence ID" value="XM_025655116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7V5"/>
    <dbReference type="GeneID" id="37158518"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="411"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="585" mass="63640" checksum="88BE02126227A68C" modified="2022-01-19" version="1">MLGGSLERDSSPSNSKPTTGEALMPIATSPPDSNPEPPPQDQPATTDASPPSNHVEPVNAAQESVAPTQGSVEDSAATSADAPKKHHLLLPIPSRASLKADRQSTLDKSQDTAHDDSENTLRGSKRSIFKGRRDRSRGSSMRSRRQNQEGASMEEDKSASPDLRDPAKPERRSKVSYRLFAFLSCCSSPSDDSEDPAIPAKRTSRQPSVPHTQATPEKADTNAGDSSTAESKDPSYYRDEKPNMTVTSNQSMSQVDEERTVTTSEQGAQLDGATVPSGAAETEKVPALPQDSAESQGLGVGQSTQPSTTTAEASAVASEAEEAAQKAEEQAISPLTEKSQDAPTAPIELDELPKPPASENSYDDEKYTSHDEEATVIPAELPPPTGPSGHHADTMLEETQQQFLLPPPLPHLRDRKCLVLDLDETLVHSSFKVLERADFTIPVEIEGQYHNIYVIKRPGVDQFMKRVGELYEVVVFTASVSKYGDPLLDQLDIHNVVHHRLFRDSCYNHQGNYVKDLSQVGRDLRDTIIIDNSPTSYIFHPQHAIPISSWFSDAHDNELLDLIPVLEDLAGAQVKDVSLVLDITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R807</accession>
    <name>A0A8G1R807_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_419098</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516342.1">
        <property type="nucleotide sequence ID" value="XM_025657842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R807"/>
    <dbReference type="GeneID" id="37161244"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF12">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH58420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="507" mass="56880" checksum="E2524B14456D2340" modified="2022-01-19" version="1">MNIVIAVAFACLILLFIYLFIYQQSPSLPLPPGPKGKPIFGNLSDLPPPDTPEWQHWMKHKERYGPITSVTILGQPIIILHDAHIATELLEKRSLKYSSRPRSVFLGEMIGWNDTLAMQPYNTRFRLYRKALHQILGTKSLVSKFNSLQELEARRLLRRMLDDPGEWVQHLKTEAGAIILKIGYGYDINPHGRDHLVDLADDSMETFSAVLNQTWLVDLIPGLKYLPSWLPFSFHKKAQSWHTQLLTTIETPYRMVREQMVSGIAPPSYLRNLLQEEDTKKEKSLSAEEKFTAKWTAGSLYLGGADTTVSTLTTFILSMALNPQVQAKAQAELDTILGPYTLPKLSDRDKLPYVNSIVKESLRWYPVAPMGLPHLCVEGDVYNGYSIPKGAVVMGNIWAITHDPNIYPHPEKFDPERFLGENPQPDPSGWVFGFGRRVCPGRVLADASVFVTVGMVLSALRISLEGGRGGEVRFTPGVVSHPVLDGVRVQARSQRHEGVIREVSVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R852</accession>
    <name>A0A8G1R852_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_182591</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518884.1">
        <property type="nucleotide sequence ID" value="XM_025654359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R852"/>
    <dbReference type="GeneID" id="37157761"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="174"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH60962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="564" mass="64184" checksum="08D2F03C865CF76C" modified="2022-01-19" version="1">MSIRFPGLSRALFRTLETSSRPALSWATWNTFSTLLVWHSCKLSVMITLLMIYAELRQVQDRDIGHLSGGELQRFAIGLVCVQKADVYMFDEPSSYLDVKQRLAAARSIRELLRPDDYVIVVEHDLSVLDYLSDFVCVLYGRPALYGVVTLPASVREGINIFLDGHIPTENLRFREESLTFRLAESGDDFMVDRARAFSYPSMEKTLGNFHLKIDAGSFTDSEIIVMMGENGTGKTTFCKMLAGAEKPDGGKSVPRLNISMKPQKITPKFQGTVRQLFFKRIKAAFLSPQFQTDVYKPLKIDDFIDQEVQNLSGGELQRVAIVLALGIPADIYLIDEPSAYLDSEQRIVASRVIKRFIMHTKKTAFIVEHDFIMATYLADRVIVFDGKPSVDAHANAPESLVTGCNTFLKNLDVTFRRDPNSYRPRINKYQSQMDQEQKLAGNYVSLQSSHLSTGIVPPWWYLLFLIGNIILTCILHSSSWKKRNEEVVPGKYDRVPHRRDGRDSDQRRRYRRWGYLRVVAFFGVTKASAAQRRRRRCRGVRLPDDVDGALEEDDEEGADDLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8E1</accession>
    <name>A0A8G1R8E1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_412762</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519883.1">
        <property type="nucleotide sequence ID" value="XM_025657583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8E1"/>
    <dbReference type="GeneID" id="37160985"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="113"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="600" mass="63847" checksum="B74981BE4A181675" modified="2022-01-19" version="1">MAARRSIVRSIPALRAASPRTAVATSRSVAAASASRRLSTVIMPSSSSTSSPATSKLSSSSPATMSATRRLHATAQQFTPATTSAATTATEYPTDHSPIANPIDTANFLDNQFVASKATTWIELHDPATNNLVTRVPQSTDEELRVAVESAEKAFPAWRATSVIAKQQIMFKFVSLIRANWDRLAASITLEQGKTFADAKGDVLRGLQVAETACGITTQLTGEVLEVAKDMETRSYREPLGVVAAICPFNFPAMIPLWCIPIATVTGNCLILKPSERDPGAAMILAELAREAGFPPGVINIVHGSAKTVDFILDEPAIKAISFVGSNRAGEYIYTRGSANGKRVQANLGAKNHAAVVPDCNKNQTLNALVGAAFGAAGQRCMALSTVVMVGETQEWLPEMAERAKALHVNGGFEEGADLGPVISPESKKRIEDLIASAEEEGATILLDGRGYKPEKYPNGNFVGPTIITNVTPEMNCYKEEIFGPVLVCLSVPTLDDAIELINKNEYGNGAAIFTRSGSTASRFQKDIEAGQVGVNVPIPVPLPMFSFTGNKKSIAGGGANTFYGKPGLQFYTQQKTVTSLWRSEDAVSTKAHTVMPTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8I7</accession>
    <name>A0A8G1R8I7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_230989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518493.1">
        <property type="nucleotide sequence ID" value="XM_025654779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8I7"/>
    <dbReference type="GeneID" id="37158181"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034233454" description="Cell wall protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="10977" checksum="E184CC78DDC05817" modified="2022-01-19" version="1">MRFSVISVSLLSLFASSALAIPAASGALSCSDVSSELSGYEQRLAKATDTSSPKYQAAQNLIDSAKNLESADCGSSNKRSYYPPESTGLVGEILNAVDSLLQALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8X6</accession>
    <name>A0A8G1R8X6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_484271</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520183.1">
        <property type="nucleotide sequence ID" value="XM_025663224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8X6"/>
    <dbReference type="GeneID" id="37166626"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH62261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="562" mass="62278" checksum="977BD9F15EC7F475" modified="2022-01-19" version="1">MEASILPSVPACAGIALVALFLYHFIIYPSFLSPLAKIPNAHPLAPYTSLWILWARYRIRENNTVLRAHQQHGEVVRLAPNEVSINCVNDGIKTVYGKGFEKPPFYTVFVNYGALNMFSSLHSPEHAMRKKRISNIYSKSFLQASPDATAIIQEVVQRRLLPQFANHANAKKPMDIYPIYKATAMDLTTSYFFGLSAGTQFVTDLTAAARWQNLYLDDQHPVSLFWLQELPGLTAWLEKLGISPVPRARHLAHDQIAAWCLNMSDGAEIMLAKKAGGSTLEPGHLPVVYERLRQSTEKEGVSTTPSITQNPVIGDDVSAAGMNGNAAQTLRTPRSPQQLQVTSELLDQLIANNGTVATTLLYVTWQLSQNSVALARLQDELRSKLGPEAFAWSASNAGDDTLPKAKDVDELPYLNAVIMETLRLHAPVAGSQPRITPANNQTTLGPYENIPGGVRVSAAAWSLHRNPAVFPRPDEWHPERWLSETLEGADKKERWFWAFSSGSRMCIGSNLALYLLKYVVAAIYANFRTHIVNDEGIEQEDGFISGPRGNQLTVAFESVKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9A7</accession>
    <name>A0A8G1R9A7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dynactin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_389119</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519885.1">
        <property type="nucleotide sequence ID" value="XM_025656734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9A7"/>
    <dbReference type="GeneID" id="37160136"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH61963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="477" mass="51291" checksum="55D5DE62D1EEF048" modified="2022-01-19" version="1">MSFNRKYAGLPDLDLAPDIYETPDLTDEASTVPTTTIRTASNADDDAGSNSDIDRQGINADEARAHFLGATVDARDVNFSDSIAMKRKAYKNKNRRRRRNENGLDEPEDISDSEDESLERKLARLRREVEELKDEMAARQTETEPEAAEGKEPTDDGVLELSRALDNLYTSRTDNTGSHSAATLLAQKIATKSTSQTAAPSTQNADATQHPEPTAPASSGVLAHAAAFDGRLALIEAAMGISSSSNPFVSDGISEPALQPVLPAVDHLTSRLTTLMNILVGPNPVSAVPTMGSAPPSTTVTTPHLETLSTRVRKLTADTEALASARKRAVDAAKAAQNARIASAAIEPSDMSVSSSSAMEVDPAATQRDEQATKIQALYATLPTIQSLHPILPSVLERLRSLRAIHAGAAQASESLDTLEKRQADMAREIEQWREGLQVVEEKMGQGEAAMKSNIELVEPWVRDLEARLDRLEGQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9G2</accession>
    <name>A0A8G1R9G2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_457474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518581.1">
        <property type="nucleotide sequence ID" value="XM_025661522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9G2"/>
    <dbReference type="GeneID" id="37164924"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052358">
        <property type="entry name" value="Aro_Compnd_Degr_Hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563:SF2">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="25"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="321" mass="36478" checksum="E0C7EFF212CABE92" modified="2022-01-19" version="1">MLSQALATHERHSNTPFLLSTESFDTHVHVFDPKLGPYAAGRAYTPEDAPLQKLLALNQSLARDYNNTTLVLVQPSPYKNDCTVMMHCLRDLRDRGIRSFGIAVLDLDTITDAQLNEMHALGVRGIRLNFQADGKDVDITHLISLLNRTADRIRYFPSWAIQLFVPGWTWDLLHDAVRELPVKVIADHLGGLRGTSKLPSELQSTPMSQPGFRSLLSLARRSIVYVKISGLYRMSDHSASTFDDLQPIVQAMAREIPDQVIWGSDWPHTGDGHNRVKRSIESKEPFRMIDNHAILQRLHDWMGDEAYWKMMVDNPGRLYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9H0</accession>
    <name>A0A8G1R9H0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">O-acetylhomoserine aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="12">2.5.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_443901</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-acetyl-L-homoserine + hydrogen sulfide = L-homocysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:27822"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-acetyl-L-homoserine + methanethiol = L-methionine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10048"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16007"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from O-acetyl-L-homoserine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.49" evidence="12"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520483.1">
        <property type="nucleotide sequence ID" value="XM_025658894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9H0"/>
    <dbReference type="GeneID" id="37162296"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000083">
        <property type="entry name" value="O-acetylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 13 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH62561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="433" mass="46815" checksum="E44A6AC13264DA4F" modified="2022-01-19" version="1">MSESKQPHFETLQLHAGHEPDSETHSRAVPIYATTSYTFNDSAHGARLFGLKEFGNIYSRIMNPTVDVFEKRIAALEGGVAAVAASSGQSAQFMAISALAHAGDNIVSTSNLYGGTYNQFKVLFPRLGITTKFVQGDSPEAIAAAIDDRTKAVYVETIGNPRYNVPDFKAIAKVAHEKGVPLVVDNTFGAGGYYCRPIEHGADIIVHSATKWIGGHGTTVAGVVVDSGKFDWGKHAARFPQFVEPSEGYHGLKFWETFGPLAFAIRVRVEILRDLGSALNPFAAQQLLLGIETLSLRAERHASNAIILANWLRKNENVSWVSYPGLEDHPSHETAKRYLKHGFGGVLSFGVKGGAAAGSQVVDGFKLISNLANVGDMKTLAIHPWSTTHEQLTVQERIDSGVTEDGIRISVGTEHIDDIIADFEQSFKAASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9I3</accession>
    <name>A0A8G1R9I3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_418498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517152.1">
        <property type="nucleotide sequence ID" value="XM_025657818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9I3"/>
    <dbReference type="GeneID" id="37161220"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="682" mass="76001" checksum="74BA79B8B57D2288" modified="2022-01-19" version="1">MRRITSFFNRPAFAAVNPGAQTSDRGNDLDQPSHSSPQSRHSNGPSSSSAEPEAQLELSLSQSIKDGENEALPHHSFLSTESAAKDPSPGTSFNSSQRVMKNGKEVVISSDGEDTDSLSSFESPDDLLARFVKPPGFVSKDDREYNTSKSGMTLRNGGVNSAKSDNRSRFPVKVPKYSNTLDSLVVQAVDDNETEAGIAKLKAALEKEDLRKNGKQDDEKHNSLVPTTQLNEDTLASALGDQDDEMGLRRLLDAVRRTEALDLDKSWHFFDYKSELPPAVDFPKDCIDKDGYMFRLRERLSRERALHSGIIDFALSRSYLPDEVISWIFKAVPSETQDSIRQALCRAFKNANPERVKSLIRPADIDQVFQQLGATSQALATSETIVPDAHINKHNVKNNSLREGMLVSVLELLSGAADLLAEDARERALNLLFRLTLDVSLTSNFLVCSELERTIVTMLESAPDDTADDMVHRVCTTVFDTVKDAMSQSRLVRHILPTSDWLALIRCRLAVSFLLNDASPLGEPPEKLINMKRITSILNQQRFDVKWYKGKGQHEYDYGELGAVAILFNIAIDSGRYEVEFSDKEAERTFNADVDALSDRLKIIFTSIEDSGASHLKRTLAKEAIEALHYRVVYSVRSKPRPKKSILGVPEERRENKGVFKSFFKPPKGSDELPLRPHDTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9S2</accession>
    <name>A0A8G1R9S2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_412394</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519679.1">
        <property type="nucleotide sequence ID" value="XM_025657570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9S2"/>
    <dbReference type="GeneID" id="37160972"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="6">
        <location>
            <begin position="262"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="430" mass="48188" checksum="81089E03EB0A932C" modified="2022-01-19" version="1">MYTLPVLIAALFLHVKFPLLPGLRDTLYGIIVLSACCAIFYPPDTRDFIRYTNAFLSTSFVIRAVELLLVHDLSHLKRLQRVSYLSSSPIYTWEPISPTLGWKRFVQICDLIINPRAVGWSYGSPKYQPPVRKLEAVPDGANGCVPKREDIVLVADDDRFSFLRGKIIRALVAYFIIDSYQSAIGRNYSSVSNFVETFLTNVLNIQASPATTEGVIRLFILPPVHWMASYAFVDGIHAATGVISVGVLRIISPQLAAEPWMYPPVFGAIRYMFTFSLRGNNNPDIWGKMWHDLCRRPFLALSLSLIPDSCPLGLKRLLVVCLSFMVSGVVHAAGTYAVSKDWFAASMMMFFFCVLPACVVVQQIISDQILPRVLPAKNNISRVVIWLVDAAFVAAWGYYTSPWFLNYSRLPEAIESIPMPVSFWGVVLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9S4</accession>
    <name>A0A8G1R9S4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_368858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517287.1">
        <property type="nucleotide sequence ID" value="XM_025655891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9S4"/>
    <dbReference type="GeneID" id="37159293"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="282" mass="30718" checksum="C8BC19CD1B4EAA4D" modified="2022-01-19" version="1">MANAVEQSPTTDAQKNVPSPSNPDRVRKPRKLQRRGGPPEASKPLDPPPDSEKPPAEADDAGEAAAAEAPEATETMDLSPDTEETQLDRETQSASWSEGELQPQLQRQRSVVSVTERVSSPSSSSPASADAYYRQARRRGQRGDMRRQQREQQQALALPALGNVGDVPRNLTQGVGDLAQNTAGRAVGTLGNTAGKALGRSIMGGRNDTQLQQQGQQQTEKKKDEQLRLRLDLNLDVEVQLKAKIHGDLTLQLLYVTLQSLCSLSSFWILCVFDYSSSTFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA25</accession>
    <name>A0A8G1RA25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_445474</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519980.1">
        <property type="nucleotide sequence ID" value="XM_025659270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA25"/>
    <dbReference type="GeneID" id="37162672"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000003">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000005">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH62058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="320" mass="36938" checksum="D5DE0371606B28AC" modified="2022-01-19" version="1">MLLLDYHNVLIHSLLTERFSGAPPVSIDQIVSDFDGVTFHLSTPESKTKILISINVKCFRELVQYGAQEVLEREYGPYIVTPEPGYDFSVLIDLENLPAEQEAKDELIMRLALMKRNAMAAPFERAFDEFAKLAEEASRYTSETAPQGVEEGGEVMAIHYREEEAIYIKASHDRVTVIFSTVFREETDRIFGKVFLQEFVDARRRVLTLQNAPQVLFRNDCPLELAGVPGIQNGNDGSISYVTFVLFPRHLTPQRRYENISHIQIFRDYFHYHIKASKAYIHTRMRKRTADFLQVLNRARPENEERERKTASGRTFRVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA31</accession>
    <name>A0A8G1RA31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_133209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520286.1">
        <property type="nucleotide sequence ID" value="XM_025654007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA31"/>
    <dbReference type="GeneID" id="37157409"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052350">
        <property type="entry name" value="Metallo-dep_Lactonases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569">
        <property type="entry name" value="AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569:SF2">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="136"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="364" mass="40528" checksum="AA9F0C21A61C2659" modified="2022-01-19" version="1">MPTPIIDSHIHLFPASHLPTLAWYTPSSPLGSQHSVDEYRLATTSTPTSPEETNSHYLRGFIFLETDRISSIEESDPTRGWSHALDEVSFLTRIITGDPIPGEGHKDVDRHLCLGMVPWAPVPGGPAALEKYISLVRERTRTEEVSKKVRGVRYLVQDKPSGDMLKPEFIDGLRWLGRQQLAFDLGVDARQGGMWQLREAAEMMNTVYRGVGEKKDRVRIVINHLCKPNLRLPYTSPDSIATHPDFLEWSSLITAMAQHPTAYMKLSGGFSELPPLTADSEPDIASLVDQVQLWTDVVFDAFGPERVMFGSDWPVCNVGGGGSAVAWRRWRSVVEGILEKRGLSQEQKEGVWGGVAIKAYGIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA76</accession>
    <name>A0A8G1RA76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_494416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520843.1">
        <property type="nucleotide sequence ID" value="XM_025663867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA76"/>
    <dbReference type="GeneID" id="37167269"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="89" mass="10423" checksum="CFF4A6087C3F5BFD" modified="2022-01-19" version="1">MLDITAYPRKMDLPVQPLCNRARYSAFMYVDGEKKLLCSQVTNGRCLLRRRRRRKKKSLLLLSYQTRGGGYSNKPDMQVSLIETNLLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAA6</accession>
    <name>A0A8G1RAA6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_444298</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520888.1">
        <property type="nucleotide sequence ID" value="XM_025658982.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37162384"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.790">
        <property type="entry name" value="RNA-dependent RNA polymerase, slab domain, helical subdomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF14">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="451"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH62966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1305" mass="148856" checksum="709559F6CB8BB5D7" modified="2022-01-19" version="1">MTFPRTPVRTGPELNKLIDSINEQFDLDIPNPLLFSPSIGKNDKSLGWSLYGRIRVLYFNRKVDLNRIFNDFEEWIISQSTVLSAGDCQWGHIPGSFANTSRDIFISNGSSTIAKEERQRYLERLINDELYLLNGSFPAPRKVDELVEEPPAPPESTLKRRLSVEEEFHTAPNSPVKDPDRPQSPISKEDAYDLPIGNVNRAGFPAFQPSNATVPFNIFKSPKKTDNDKPSKFVERLRGSDSYQHYDATPTSNDRANFSFSTVADTSSSFLYSTTAPYETSFTSSTTEVDESMLETEPMYEDSVVGHHLSEQTTATNLAEIQNSEQLACQEPRESIEGRIMTGLLQSGPFSLDHQYPSSVTLRYRYELERVAREWGVSLDRMLVGPNISFKTLDDFWRWIEGHSQREGKRLPEKSSRKAWDAATGKFRTDKHSEVVVLTGDLEWSNKGVLKLRLNPLKTERTCRFHRRFGSDRFLSLTVPAPARPPSHLRFPLQPTLLRETLGLWLTQNAHQCLGRTWRPFFVDEVKSKRKADETKFRIDFFAIDGIDFDHSSPVPPIAPPHQDSSNHTPMSLDALIDWHMPREENLTQTNCKLFQRFSLALSKTYATVVLQPRQTPPLPDVSKPVMNDGCALMSRSLANQICDSLGLTGYTPSAFQGRIAGAKGLWMVDKHRSHVTADDDVWIQISDSQLKIRPHPHEWDGSVDDEKLTFEVVKWSKPLHPANLTIQLLNILDHGGHIKEHLADLTRSGIQSLYQEFADVLESDSAVLCRSLVQKIRPLGDDGFGRVSQRTWRIENWMSNDAEFIIRLTEAGFCPRSFHFLRKRLGKCLRELLKRHVDELRIEVPLSTYAFCIADPYGVLKEDEVHFGFSNVWRDGKGQFEDILLDGIDVLVGRLPAHLPSDIQRRTAVWKQELRHFKDAIVFPSVGNIPLAHMLSGGDYDGDTPWICWDQNIVRNFNNSKLPDIEFAPEYYGLTKYAVDMKDIQSMDEFLQSSFTFNLTLSNLGRCTVEHEMIAYDESIDSDKAKELACLLSHLVDGRKAGVHLSEQAWRQYRKKISPRARELPAYKNPGRRPKKSNIIDYLRLEVAAQERDKMLTKLEAEFPEEEAFFSKDEDLTRPWRTIREKIKNEGQRGQLFAAAKGMREKIRKLYIQWNTAISRSQDSFSPHALAAAGEARSIPPPEGDHPLILVWQHCRDEWLRVLASYTYNEYPRASFVMHAFGEVLCQIKSSTLPARSVTSEILSCYRVNQKVVAQLTAQDVVEEGEERLDGEDEYEGHEAIEAMHFGMRSSGGYFDPDDCLSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAM0</accession>
    <name>A0A8G1RAM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_5381</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520605.1">
        <property type="nucleotide sequence ID" value="XM_025665463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAM0"/>
    <dbReference type="GeneID" id="37168865"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF2">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH62683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="536" mass="58955" checksum="B6DD47E341B17D73" modified="2022-01-19" version="1">MKSATPFLAAAGVAAAKNCSVDTIARFLPKNATVFYANHYEKGYNFTPAIEYNYGLTSDPMGISAYELPLAGCVAQANISLPNNTQHSVGLVLPDEWNGRFMAVGNGEFAGSVGWSSIINTMWYGFASVSTDTGHEGNNGSFGYHNEAALTNWGYRALHDAVVNGKKVTEGYYGKDISYSYYRGCSAGGKQGFKEVEMFPDDFDGVVAGAPAWWTSHQQLWNVLTAIWNLPETADYHVSDAQMTAVQDEILKQCDPQDGLKDNILQNPFGCVFDPVPVMCNATSSNDTCVTPAQLKTVNKLFNPWYEANDTLIFPGYTLGTEVGAPSLDDDFVTYIQYMLQIGGDWTWKDWNPDLVALSDKINPGNATADDFDISPFYKKGGKLLHYHGYSDPSIATGSSVYLYNHIQEALRPQDIPIDDFYRFFLIPGMEHCTSTPSDQDAPYYMNGDSQAASLSGTVFGVPGFNDPKHDLVLAIMDWVENGTAPDYLIPTKFKNDDVADGVDKQRPICPHPQLAKYKGSGDVDKAENWYCSTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBH4</accession>
    <name>A0A8G1RBH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_444475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521055.1">
        <property type="nucleotide sequence ID" value="XM_025659022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBH4"/>
    <dbReference type="GeneID" id="37162424"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="120" mass="13656" checksum="65C08EF9294EC223" modified="2022-01-19" version="1">MSDSSESISLQVTVHLKPEDVPKFWAAFEPAYKAVTAEPECTFFELYQSLDSPGTISWVENWSASKEWLMGVQLVKPYYRDYFAATEPLFIKPREAKLLKRVGTPFTMVKKTNGGLVDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBN6</accession>
    <name>A0A8G1RBN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_6050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520639.1">
        <property type="nucleotide sequence ID" value="XM_025665515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBN6"/>
    <dbReference type="GeneID" id="37168917"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH62717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="562" mass="63510" checksum="5D7D4DE91BFEE3A4" modified="2022-01-19" version="1">MESEKKRRASKPKVKSGCRTCKIRRVKCDEGRPACKRCVSTGRVCDGYGIWSEGRKTTYGGSSGAPRVFQSLLSSYNAPVPVPHAACAEQKCVEWFIECTIFKIGGVFSSQFWGRTVVQALSQEPAVRHAVMALASTHKYRAQRSDKDTTMASQLSEHEKFTLQHYNKAIGCLHAEIRRHSQRPQSVIVALITCMVFVTLELMRGQYRMSHAHLQHGLKLVKEIQKLSGTSKTGKIMIRTSSQTNEDDVIEAFSRLGVHYALLGHGTKYSNLDYDIQPRHLPYKFESIEQARQYLDVLLAKAQCLVELVRHIETGMCVATRGYEQYLESQWRLEKDLEIWLDVYRSSLDGFSAQDLIKDTLATRLLGMYHTMASIMVRTCIPWDDDTAFDLQTDRFMSIIREAIDMCQALRTAYPDFPMSGSLNCPLGMAFTIDIGFIQPLYYTAIKCRIPQIRRHAIGLLRLAPHREGIWNGALTARIAEEVVAYEESNIDTSCTVGKSLDLLSLPEAGSSITILPSLCRISDVHVELPDENTGEATVTFWQRDDGRSWKVGERKFQTEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCC2</accession>
    <name>A0A8G1RCC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRM5</name>
        <name evidence="14" type="ORF">BO85DRAFT_467159</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="10"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06869">
        <property type="entry name" value="PX_UP2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="200"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="13">
        <location>
            <begin position="1398"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="299"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="853"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="983"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1088"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="853"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="878"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="992"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1489"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="1527"/>
            <end position="1528"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="1555"/>
            <end position="1556"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1613"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH60685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1724" mass="194357" checksum="8DE68D79C677CB54" modified="2022-01-19" version="1">MTSADLSSVPNGVQSGAAAAASPAASNPAPGQILTGKQEHYLKRELIARQVQSEISELNSPTALRRFGAPFKSEFGEVAPVDSELPILRYIFVHHVRNFPFLDQAREKEFWQDKLQVFLESFATKHVSSSEDRLEETKRRKLARKCEKLVELMMVSGIPTASGYEERIQFSEMEVVDRGANEKGLLVNMPEGHAIHGWDVNVAAVRVTSVRRTVRYHQHAEFILRVRRDGKPDLFVARRYGDFAKFHKRLRTEFPGKPLPPLPRKNKSSTTTSWFGSADDEASSVSSVSTVGVAVVDDGTSSRNLAPGNHHQRSLSRSSRRSVRSPRASSDGSRETVLYREEQRVSLRAFLRTLLQNKRIAETKAMEEFLTADPIILNEEEVLDMQKRKDVDAVRIEEQKRFYEIARARAAELDVYMENFRRDIVESNGLTKLFAEIKEKPTVQDLSPKYQKFAEWLRIEVAATLYHLFLAEDNSPELFAQAKRIHSLVPYTLLKNVIRIANPAAVMAGVLDLFLAQPFGSRSLLQRIFSMTLNDGIKAFQKSIDALAAKVDDTILCQKLKAFTDADEEVKNEIRAEAAAEDVDIIVAILRSEYLQPELAPEQFGKVFNGYVAWNQAVDNIEVEMREGAHWFANLKQLLKLYTRQRDKAMMLSIVEEPTTLQLFRDLFTIFYEPLVRVYKSANVYSSITDFAHFADDAIAVIEKCQRQDVSADPNQTVQAFIDLCERHQSSFYKFVHEVHLHDNGLFSSLMAWIEEILEFLRKGPRGGALDMNALLRGATDFVQIDKDKALEEINALIKWHEDRKRWHLNKTRQKMAAEGTAHDGYLGNASFRGSDFGLDEADLEDLAISDAESEASEDLDDEEDLDPISAERRRRVKQQDQLRRTAGEPVKPDISEILKLSESFGVMLRQSIASFASHSGSSAGSLPRWRLALQLSRASSSREIPNQEPRFYVCQKPQEKRCRFFLWASDAEVREKHAVLTNSRTEPAADSFSSTTTTTTISTPETSSKKPRLSEAGLLTPQTDRTVRFGGMGLDNSGARGKGGRLSATMPPQSAKARMMAEDFDEFEWEDTDDAVVESIFSPQEQRLQQAAAAAAPMRQPNFGPPKTPSRDAVGASAPGKRKFDNISDMDAQDGSKTEVFTPTSLARSFTDRAVSFSSSVPPSSLEFSKTPTPVRFGASPATGGEKASSELAAQAVEILDRNKVVMSEKAKGELMDLLQKHDLKVKGIVRGRDISRIALKKKDDQIKALNERVAMLERSDLPAMFRPPVNRAMRVLDRSFFKKTVPISAAAIFKTSDISNVRKELTKSRDMLVLPRLGSIREIKINDLVHKCLLLREDIKHDDTATWSPTISELVKKGMVGVKPYDLTLDYDYWTYADIMSCILPEDMLDEIPQGFTQVGHVSHLNLREQYLPYKHLLAQVLLDKNPNISTVIRKTEDVGSHSEFRTFPFELLAGENNLNVVQHEQHCEFRFDYSRVYWNSRLETEHRRLVDKFRPGEMVCDVMAGVGPFAVPAGRKKIFVWANDLNPHGYEVMLDAVKRNKADKFVTPFNKDGREFIRWSAQALLDSPHTVTIEPKVRRSKKAAAEEKGEALPAPEVFHRPNVFHHYVMNLPGNAIEFLDAFVGVYAGKESLFAPHTSQPLPKVHVYCFSGHSADEHDDHVDICQRISERIGHTITTEDRVGGSGNQEIDLAIHNVRLVSPNKQMFCASFRLPKEVAFRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCE4</accession>
    <name>A0A8G1RCE4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_27113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521546.1">
        <property type="nucleotide sequence ID" value="XM_025655092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCE4"/>
    <dbReference type="GeneID" id="37158494"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="191" mass="21233" checksum="51DC917CAF9702E9" modified="2022-01-19" version="1">MLTSSSTDSSRSSFSGSPVSQHPPHHQVWFPPAPRRRPQHYKIPRYYSTPVREDVPDSTPLQMYGLEERAPSIAEKPKLLRRFSHALDDIKEDLTLQPSSEKIRSKRRQSIFGIDEIPGSSGSISSPSMDVPVAAEPQPPRPRPLSILASEPSRRLSRRFSIFGSRRSKKLTPGQAGSISQPNLIGASTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDH3</accession>
    <name>A0A8G1RDH3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_361040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520979.1">
        <property type="nucleotide sequence ID" value="XM_025655576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDH3"/>
    <dbReference type="GeneID" id="37158978"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="28"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH63057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="342" mass="38828" checksum="B75C5C79BAFD91DD" modified="2022-01-19" version="1">MANNYIDEATFVAVLWVCQTITFFFVLIRLLLQYLVDRKWHTHDALILTAWVLSLANCIVWSVCYKQMFYITTLTTGSIDYSNLPENIAAIQVRYLRGQLAGYLLSYTSLWSVKLSFIFFFRHLGNRFRAQRILWWVVLAFVIACYGGTLGVLDYACEMASFEDSIEACASAYSIWYERVSLKVSTSMDIVSDAAIIILSGHVMWRVKIDIRRKLALIGVSFLTAFIIIIALVRLELSVSGTGILSPAWLVFWNAIEICVAIMMACLASFWTFYTKLKRQSPGPRWRAGGLPPRDYASLERPILLNGQFSDRDKHNHSALSMQSHNSQNTGQGAPRGKTEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VFX2</accession>
    <name>A0A8G1VFX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_524983</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="KZ825099">
        <property type="protein sequence ID" value="RAH51636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509558.1">
        <property type="nucleotide sequence ID" value="XM_025665450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VFX2"/>
    <dbReference type="GeneID" id="37168852"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF3">
        <property type="entry name" value="BETA-GLUCOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="12">
        <location>
            <begin position="416"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH51636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="871" mass="95764" checksum="BA6BF11C4EAD23DB" modified="2022-01-19" version="1">MASIPPDLDHFCTSNMDLEVILRSLTLPEKVTLLAGASTWRTAPVPRVNIPHLKLSDGPSGARGEIFGDSVPAAFFPSGTSLGATWDEDLLGELGQILAEECKSKSASVILGPTMCIHRHPLGGRNFESYSEDPYLTGRLATATIRGIQSRGIGATAKHYVANDQETDRFHYNAVIPTRALREVYLRPFQMVVRDANPWCLMTAYNRVNGAHCDENVELLTDILRKEWGWEGVAMSDWGGAHDAAQSLVAGLDLEMPGPPVRRTWEIVQQCLADSRITEADVDRSVHRILRLLKRTKRFENDSEHPETTLRNSNNTARLLHAAQSGIVLLKNEAGCLPLRPSEGLGRVGIFGPNSARVVAGGGGSSYIKAPYWTNVDDSLTARFQDTTTEIVRNVGAKVNRYLPVISLAATRNPDTGGQGAAIDWFSGHDLSGQPTETIHTDDLYYINFGNTPQTIATETGFSFRLRTTIVPLTTGTHRLSLASIGPSKLYISGQLMAHQDGNFEKRGTLFFTYGSHEAIFTLDMVAGQEYHVEIEYWSHDRQLSAQLLPCMDPMEDKFQGVRLGYEEANRRDLPSEAAKQARDCEAAVVVVGRDREWETEGQDVPMFALPGEQVRLIEEVAAVCARTIVVIQSGTPVHLEPWIENVKGVVCAWYQGQELGNATASVVCGEFNPSGRLPMTWPRRLEECPAFSSFRVEAHEILYAEGIYVGGRWWDLLGTQPMYPLGYGLSYNTFALRIVHPEQLAMVTGPQPVQVIVEVTHCGDGAVGLPGRETVIAWCEVVDSGNGRLARPPKQVSAFIKSPLLAPGETCTVSLSITAYELGVYDPERQKWVLDKGAEFRILVGADAAHTQEAGTIHVPETITWVHCID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGY4</accession>
    <name>A0A8G1VGY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_171535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510696.1">
        <property type="nucleotide sequence ID" value="XM_025654291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGY4"/>
    <dbReference type="GeneID" id="37157693"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="158" mass="18062" checksum="EB34F233D21623C6" modified="2022-01-19" version="1">MPDEPSDWAKEACSACRCMYLSGQAGLGRILIHKSYAFRLISSSHYYEKWIAIWTSHGSGSLTNTFSSFLWSLPLHPASAKDKYIIFHIHVNRAIDDTPSESREELFKPLPTPHFTPPSYRLRGGHKIRNSTWNGMDEPGRKGGRRNHPQRNIQLKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VH76</accession>
    <name>A0A8G1VH76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_464336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825090">
        <property type="protein sequence ID" value="RAH51952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509874.1">
        <property type="nucleotide sequence ID" value="XM_025661978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VH76"/>
    <dbReference type="GeneID" id="37165380"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH51952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="104" mass="11728" checksum="89D7BA67F4C1493E" modified="2022-01-19" version="1">MDWAAMVEDARKTPELQTVGKGNQLLTRSLYVDKGVRVNGAKKEQTHPDIIHQPANELEKDVDGAMGMDELRLSDTTPSLKADKSKQELHRRRPLEAPKKKIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHV0</accession>
    <name>A0A8G1VHV0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_503784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511643.1">
        <property type="nucleotide sequence ID" value="XM_025664255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHV0"/>
    <dbReference type="GeneID" id="37167657"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="38"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="374" mass="43660" checksum="7B39E2CFFC447143" modified="2022-01-19" version="1">MTATESTTTTMATQEPTTSTKLIASSTPTPKMDTVFSIVELVECILLRFDPFDLMRAQLVCRQWRTLITTRSPLRAVLFYDFAHPYPTEPTFNPLMRYLFPVLFPTPDFTKPTSPIFMPEDIQHMRLGDDTAYHKAVFRPEASWRRMRPMNIPCRVRKVVRKTVRDDQNPAKNLLVYDKEAGQDPVLGATMELFWDVLLHELGYWPTNGMAVEWRTVREGSGDWDNNWKEGVSDEEKRRLRAPYECSFVSASPEGMLGRCDRRKFTFVRVKPPIRMKSTAEGYLGMRNQYVLDKFESKFYGPDKPPKFAHRGEWEWINDDGTKSYDPSKYAPNDEDNIWPVPDEDDSGTEWSWDEAKEYFDRPECYWVPTHTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHV5</accession>
    <name>A0A8G1VHV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_151126</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511658.1">
        <property type="nucleotide sequence ID" value="XM_025654145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHV5"/>
    <dbReference type="GeneID" id="37157547"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="3">
        <location>
            <begin position="75"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="394"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="622" mass="68984" checksum="9A38A6376C50CFFA" modified="2022-01-19" version="1">MENPQTDPNMSSRQDGFSSDNKLATNKAMASSVTDNPRAIKLEHNSYTVGWVCALPKEQTAATAMLDKIHPQLPKPPSDPNTYTLGCIGRHNIVIACLPKGQYGTNSASAVATRMVGTFPSIKVGLLVGIGGGIPPKVRLGDVVVGTPVDQCSGVVQWDLGKAEAEGGFKRTGVLNNPPTALLTALTKLETMHEMGGPKIRQYLDDMEQKWPRLMPKYTRCDSLVDPLSGSDNCARESQHGEGHVHYGLIASGNQVIKDAHFRDNLNKSLGRNVLCIEMEAAGLMNNFPCVVIRGICDYADSKKTKSWQEYAAAVAAAYAKELLEYVQPSDVDGERPVKDMLGDVLKCVSRTETNVETMKSNFDRKGELDILEWLTPIDYGPQHSDILKRRQSGTAQWFLDSAIYQAWISSNKQTLFCPGIPGAGKTILTATVIDDITARFLHDKSVGIAYVYCDFRRQNEQSAEALITSLLKQLSQCRPSLPGIVRSLYDRHRHRRTRPELDEISTTLRSVGAMYSRVFIIIDALDECQTSNDCRTRLIKEILNFQATCGGNTFATSRFIPQITERFNDCMTLEIRAHDQDVREYLRSRILQCESRLLASHSEEIQTEITKAVDGIFTSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJB7</accession>
    <name>A0A8G1VJB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF952 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_431299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510505.1">
        <property type="nucleotide sequence ID" value="XM_025658330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJB7"/>
    <dbReference type="GeneID" id="37161732"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.20">
        <property type="entry name" value="Protein of unknown function DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="BLR1139 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129:SF1">
        <property type="entry name" value="DUF952 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15198" checksum="7996FC76E29B1CF4" modified="2022-01-19" version="1">MADAEPLYVYKLIPSTSPVREPLPDRLPVSELDEKSGFVHLSTAFQVPNTLKMFFKDEPLVYVLRIPYEGIAGQVRWENPDGTVCGPRPKEGLFPHLYNDLKLGKDEVETVAIWKNDEGWDKALLQAKPWLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJK0</accession>
    <name>A0A8G1VJK0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">beta-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_376502</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513428.1">
        <property type="nucleotide sequence ID" value="XM_025656226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJK0"/>
    <dbReference type="GeneID" id="37159628"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000021">
        <property type="entry name" value="Probable beta-glucosidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF14">
        <property type="entry name" value="BETA-GLUCOSIDASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034776053" description="beta-glucosidase" evidence="16">
        <location>
            <begin position="19"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="17">
        <location>
            <begin position="709"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="186"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="209"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH55506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="793" mass="84440" checksum="A51FF0574EC91580" modified="2022-01-19" version="1">MKVLSFIVAAALLGLTGASSNSSQGLLKSDGVALGDWDSAYQKASSFVAGLTTDQKLALITGSSVNSTNGSFSGLTFLDGDMGLQNFYYVSAFSLSSALAMTWDRDAIYAQGKAVGSEFYNKGIQVVAGPTSQPLGRTPWGGRNVEGFGPDPYLNGLATGLTTKAYIDAGVIPGAKHFLLYEQETNRTGGGGGGGPGGGGMPSGGMGPGSSNTSSMGAKPTGSMGRRAASSSSESDSGSAPYSSNADDKTLHEAYLWPFYDAVKHGLGAVMCAMTKVNGTLSCQNSDLLMKHLKTELGFPGLVWPDTNGQSSALESALGGEDYGSSSIWSTSTMETLLSNGSLSEARLDDMAIRNLMGYYYVNLDNGLQPEEQSEDAYVDVRRNHSKLIRENGAKSMALLKNKNALPLKKPRVMSVFGAHAGPVLGGPNTAMDIEGSGPTYQGHLATGTGSAQASLPYLVPPYVALTNRIIEDGTMMRWVLNDTYTSSSTSGLITEGTDSTAVDPSFTNYATNSDACLVFLNALSGEGADRTELYNDDQDTMVNTVADNCNNTIVIINTVGPRLMDQWIEHDNVTAVLYGSLLGQESGNSIVDVLYGDVNPSGRLIHTIAKNESDYNVKICYTAQCDFTEGVYLDYRYFDAYNITPRYPFGHGLSYTTFSYSDLSIEKPSTLSKYPTGEQTVGGHSDLWDIVGSVSVKVANTGSLDGAEVPQLYLGFPTAAQQPVRQLRGFERVEIASGKQSEVTFKLRRRDISYWDVRAQQWLVASGDYKVYVGASSRDLKLNGTFAVQTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKL2</accession>
    <name>A0A8G1VKL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catalytic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_452973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511750.1">
        <property type="nucleotide sequence ID" value="XM_025660960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKL2"/>
    <dbReference type="GeneID" id="37164362"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF64">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="223"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="452" mass="51040" checksum="70CA87815CECEC8C" modified="2022-01-19" version="1">MPTRRIWHCAQRVSPGLGGPPSIIRKARTPRPPSVWFQNHIPSQNVYTVVRTTRRRPTPYHHMYQPLHSSSCPQLRTLFTESIPPILIPPVIFTGLLLSLWTWKCFWIVVMQEKLLYLTWLPPFARSETVSDYEGQCKPVCWQTHQIRSRDGTKLAICEGRIPVKATSPGSIQESRNHCKKKLVVICYFQGNGGSTPMRLPLLSQFLRAMHASPKSAASASEEKDYAMVALSYRGFWTSSGRPTQQGIELDTQAFLDWVKETYVAPDTDLQVILWGHSLGTAIATTGLATYLPRSHTAKPQAPASIAGVILEAPSSSVKDMLISLYPQKWLPYRYLWPFLRSHWDSILAMERMARWRDDLKNIDYQNVDSKGDKAVLPPVLILSAERDEVIPPHAADDLEREGKRLGLDISRKHVLGALHTEIPVKPSGREAMVDFVARCTSRPAGDRHNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKN6</accession>
    <name>A0A8G1VKN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_72683</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fructosamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513414.1">
        <property type="nucleotide sequence ID" value="XM_025665618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKN6"/>
    <dbReference type="GeneID" id="37169020"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1200.10:FF:000018">
        <property type="entry name" value="Fructosamine-3-kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH55492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="345" mass="37578" checksum="12EA0A5B8CDCDFBB" modified="2022-01-19" version="1">MAPVPATLLRALSISDPAKASLSTAGLGSGFTNTGAIRATVPRSDGSGEEERRYFVKTSPNGEAAEEMFRGEYESLNAIATSVPGFCPRALAWGPLEESAGTSFFLATEFLELGGGGRRGRGDTLAQRLGKLHSTPAPPDPATGRRRFGFPVPTFCGDTKQHNRFCDSWADFYANERLLTILESSETRNGRDAGLRGLVERTARTVVPALLRDGHLGYDRDGNGQGIIPVVVHGDLWSGNADRGHIVGSGRKDDEEVGDVVYDPSACYAHSEYELGIMKMFGGFGSAFFTAYHRIVPKTEPVEEYEDRVRLYELYHHLNHHAIFGAGYRSGAVSIMQKLLRKYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKV7</accession>
    <name>A0A8G1VKV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pre-mRNA-splicing ATP-dependent RNA helicase PRP28</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Pre-mRNA-splicing ATP-dependent RNA helicase prp28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BO85DRAFT_398509</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the U5 snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the PRP39 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515091.1">
        <property type="nucleotide sequence ID" value="XM_025657057.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37160459"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000451">
        <property type="entry name" value="mRNA splicing protein (Prp39), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000322">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000064">
        <property type="entry name" value="Putative pre-mrna-processing factor 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057479">
        <property type="entry name" value="PRP28/DDX23-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25430">
        <property type="entry name" value="DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 23" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="22">
        <location>
            <begin position="992"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="1023"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="1240"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="627"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="736"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1394"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="18">
        <location>
            <begin position="992"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="635"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1395"/>
            <end position="1405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RAH57169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1430" mass="160882" checksum="3A0999F590047234" modified="2022-01-19" version="1">MADYNYGGSEEENAELKKLETELLDDPDNFETWEKLVRAGEALEGGINRNSNPQAITTVRNVYDRFLAKFPLLFGYWKKYADLEFSITGTEAADMVYERGVASISPSVDLWTNYCSFKAETSHDADVIRELFERGAASVGLDFLAHPFWDKYIEFEERLEAFDKIFAILGRVIHIPMHQYARYFERYRQLAQTRPVVELASPETLTQFRAELDAAAGHVAPGAKAEAEVERDLRLRVDSYHLEIFSKTQTETTKRWTYESEIKRPYFHVTELDEGQLNNWKKYLDFEESEGSYVRTQFLYERCLVTCAHYDEFWQRYARWMAGQPGKEEEVRNIYQRASCLYVPIANPATRLQYAYFEEMSGRVDVAKEIHDAILINLPNHVETIVSLANMSRRHGGLEAAIEVYKSQLDSPQSDLATKAALVAEWARLLWKIKGSPEDARQVFQKNQQYYMDSRPFWTSYLNFELDQPTSASTENVQYERIKQVIEDIRSKSTLPADVVRELVQIYMVYLLERGTKDAAKEYMTLDREVHGPASVSKMKAAEVVQLPPAQPVPSATPVAEVVVPTPPQANPYAYYQQTPVNGGIDGVLSERRGGICNVQSRFSTALPDMMGYGWVDLMIAMDGIMTNGSSEAHPPMPPPEPIERPPTPPPPPPEDSGLPPPPPDTSAPPPPPEDLPPAPPPETEPKKKKVGWGTKRPAPTPLSVEELVRKKREADAAAAKPKFLSKKEREKLALEKRAQEVAATRRLKSEASNGVDRSATHSPSISSEGPNGDARSIPTGPRAMRNSDSAPTAPAAMRHSQSHNKNYDLAPPPPPKSMSFGLTSGKGDSRFVDEDEAAAQAALVKQRYMGADQTSNFSAKKKRKRTTDRKFNFEWNAEEDTSGDYNPLYQHRHETNFFGRGRLAGFGDDVAESVAHKYARALEYRDREAGSIRAREILEMERRRREESTRNQLDKHWSEKKLEHMRERDWRIFKEDFNISTKGGSVPNPMRSWEESNLPKRLMELISRVGYKEPTPIQRAAIPIAMQNRDLIGVAVTGSGKTAAFLLPLLCYIAELPRIDEFEWRKADGPYAIVLAPTRELAQQIEIEAKKFTGPLGFNVVSIVGGHSLEEQAYSLRDGAEIIIATPGRLVDCIERRMLVLSQCCYVIMDEADRMIDLGFEEPVNKILDALPVSNEKPDSEDAENPLAMSRHINQDHHRYRQTMMYTATMPTAVERIARKYLRRPAIVTIGSAGEAVDTVEQRVEMIAGEDKRKKRLGDILSSGEFRAPIIVFVNIKRNCDAIAREIKQWGFSSVTLHGSKTQDQREAALASVRNGSTDVLVATDLAGRGIDVPDVSLVVNFNMATSIESYTHRIGRTGRAGKSGVAITFLGNEDADVMYDLKQMLIKSPISRVPEELRKHEAAQSKPTRGFSSKKNNEEGGSGGKSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLE1</accession>
    <name>A0A8G1VLE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_497005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514239.1">
        <property type="nucleotide sequence ID" value="XM_025663973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLE1"/>
    <dbReference type="GeneID" id="37167375"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="36"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="307" mass="34297" checksum="B9203F3ED145B2C3" modified="2022-01-19" version="1">MDHFNHTASIGTHTLSYALRGPPRQPNTPLVITLTGITSSALEWSAVCRHLSTDASILLYERSGYGRSEPSPNPPDSLTIINELCHLLDAAALAPPYLVIGHSWGGILAREFLAARPDDICGMVLVDPVQERMMMETWPDPSIAAVTDGLDYMDVVGLVRDRVLTDEEWDDLMAEENSEKHAKQAALEMPFLQVSRGVLAEKEQLVPGKDVMRGKPLSVLGGNSKRDHELLYEAGVAKGGGTDAQRERFREYLARWKRCEEEFHRELLSLSSVARYSVTKRSGHNIQLTEPELIADEVRWVLKMIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLU4</accession>
    <name>A0A8G1VLU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_468589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515873.1">
        <property type="nucleotide sequence ID" value="XM_025662276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLU4"/>
    <dbReference type="GeneID" id="37165678"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF6">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="39022" checksum="D44CA43A79D4B507" modified="2022-01-19" version="1">MSLSSAEKKRIRDRRAQQTLRTKKQQYTAQLEDKVAHCERYHDDSGTQHLLQVIEGLQQENQVLRNRQEGLKSLITSWEDPSSSPSHLLQPQPPTQLPLPPIQSYTTTPKPSSSSSSSLSPPPPQTNKEESIPPLYSLLPLHSDLPTTPSLLWLALPPSTIISCPPSPHPLDLLYGTNTNPLANAIYTTSLRRPLRDPERLAFGWLSYHYSKWLFNPTSETFAKLPTFMHPVQEQLRIPHPASLDMLIWPEIRVTLIREWEVYSRQRDDLFGFLACCMKVRWPWGESLLERDEKNDLVIKTRFKNMIMCKEGWGITREFVDVWPDVVRGVDVGEVLMEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMP2</accession>
    <name>A0A8G1VMP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_372578</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515649.1">
        <property type="nucleotide sequence ID" value="XM_025656043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMP2"/>
    <dbReference type="GeneID" id="37159445"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH57727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="496" mass="53913" checksum="D9F3317EFCC0BE67" modified="2022-01-19" version="1">MLFGYDQGVMGSLLTGPSFEATFPSISNGNSTLQGFAVAVYELGCAAGALTVIFSGDKFGRRLTVMVGELIIIFGAILQASSFSLAQLIVGRIVAGFGNGMAAAILPTWNGECSRSKNRGRAVMWQLNINLFGIALAYWVDYGLAASSLTSNNGWAWRLPLGLQSAFSAVTIVLALFLPESPRVLMRNGKVDEARDVVDMLSLEEDPATRASEVCTVVSLIENALQEDSQSDSQWQAIFTQGRPRFFQRLILSAFVMCMYQLTGVNLITYYVHLSLLMSGFVGLEFWIASFIPIPLIDRLGRRPLLLFGAVGQCVSMAVLAATVAYPGNKACGYVSVVCVFIFNTVCAIGTNGLAFLLPVELTPLQTRGTSVAISTGFFWLCNFFVVMISPVLISRIQYGTYILWASFLRRTLQIEIPEFEPSVNNLDTAVPETCKASLEDIDVLFENNPKWPIGPQSKKKMAKITEDASALTDAVLHGRKESAPTVDMVENASSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMP5</accession>
    <name>A0A8G1VMP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">9-cis-epoxycarotenoid dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_511603</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516981.1">
        <property type="nucleotide sequence ID" value="XM_025664611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMP5"/>
    <dbReference type="GeneID" id="37168013"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH59059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="516" mass="57736" checksum="25C6D9794A0D9371" modified="2022-01-19" version="1">MAGQQKNLYLLGNFAPIQTTVSDITCVVKGSIPEEFHGGQYVRNGSNPLKDDTKHDIHWFDGDGMLTGVFFKRDLDTPRAQPVFSNQYIETDVYSARKKSPWIYPVIPGMNTMIDPRSSSIKIAMSLVRTAAIVTASICGWIARPIKRIGTANTSLFHHDGRVLATNEIGPPMRVFLPSLKTVGWFTGSQAEGESDQKDSSKPYFGAPGLEGVYKEMTTAHPRVDRETGELILFHSTFLPPYINYSIVPQGVPTNATPALNQAVPGLKSGKLMHDFGVSHRHTVLIDTPVSLDPYRLRHGRPAVEYDPAGHTRLGVFPRHSPDRQWALSAIPFEFPHVPGHLQMSVTKFVYGCSMREGNFATTHNSCFKIDSLVKVNVESILRKGLDNPPSQVHGCVDTRSIHEIINSEDPHDPIKVFALPPRHYAQECSFVPRKDGVSEDDGWLVTYVFDESWLDDRGDPLPDAHSELWIIDAVSMKEVVGRVILPQRVPYGMHGNWFSEEEILNQRGVHHYRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNE0</accession>
    <name>A0A8G1VNE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_519528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516607.1">
        <property type="nucleotide sequence ID" value="XM_025665061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNE0"/>
    <dbReference type="GeneID" id="37168463"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01519">
        <property type="entry name" value="RHOD_HSP67B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="89"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="225" mass="24752" checksum="09E7D00FA84FD609" modified="2022-01-19" version="1">MASLLPLRRAPTSLLTSTSKPSTHLTRSLLTSTVIPSTRTFTTRSSTLLPNTITKRTTTINPITRPHHHPLISSPSIRQKSTKDNEAPTFRQWGFEDITASLPSNTPDSPTQKPIILIDVREPAELFTGIIPSAVNVPLASQPDALFLTPEEFETRFGFPKPGVKGEEEDADIVFYCKAGVRARAAAQLAEQAGYEAGRLGVYDGSWLDWAKRGGRVERWEGNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNF7</accession>
    <name>A0A8G1VNF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_448560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516474.1">
        <property type="nucleotide sequence ID" value="XM_025659969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNF7"/>
    <dbReference type="GeneID" id="37163371"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="180" mass="20907" checksum="B07E5CF0EBD3014E" modified="2022-01-19" version="1">MQSTTIMEEHEESEYLEDSEDSSDISDGQPECNYIYHDDLPILPTCYVYVAILPGDGVLKHWMLYIDAPTYTEKPIIHLVGSPDSYRVETRFLTDEDEDSFIDRVNLCDIPNRQGVYDAIINAGERARVNNQDPSYNSQVYILRLLRALERRRIVSNKDSKYKEAKKKLKGKQQRPNVMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNU1</accession>
    <name>A0A8G1VNU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_369491</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517087.1">
        <property type="nucleotide sequence ID" value="XM_025655925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNU1"/>
    <dbReference type="GeneID" id="37159327"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF20">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="28"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH59165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="415" mass="46559" checksum="774298890BAFA94D" modified="2022-01-19" version="1">MTVLNLTPLPADEIFALNREYANDTFPDKVSLGVGVYRTDDGKPWPLPSVRKAEQQLLAEDSPFRHEYTAIEGDIPFLELARDLMFGFDSKNLCEEHKALKARIGSVQSVAGTGANHLGALFLAHKMKPKTVWLSDPSWANHVTIWDLVGVPRKTYPYYKPETRSFDFEGMMSTLESDAQEGDVILLHACAHNPTGLDPSKEQWKAIAQICERKKIFPFFDSAYQGFASGSADEDAWAVRYFLNEKPHMEMCVAQSFSKNFGLYGQRVGAFHYVVAEGSQNLRDLVVNNLCHFIRGEFSMGPTGGCSIVKKVLTNDALTTQWHDDLKVMSSRIKAMRAALYDELVRLETPGTWKHIVEQNGMFSYTGLTPTQVQALKEKYHVYLIKSGRASISGLSQKNVAYVAKAFDDIVRNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ24</accession>
    <name>A0A8G1VQ24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial proteins import receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_483610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519501.1">
        <property type="nucleotide sequence ID" value="XM_025663170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ24"/>
    <dbReference type="GeneID" id="37166572"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005687">
        <property type="entry name" value="Tom70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00990">
        <property type="entry name" value="3a0801s09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="64"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH61579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="629" mass="69580" checksum="6A2DFE3678672325" modified="2022-01-19" version="1">MSSQSPLPQPTKNVVLDTTSLPPSSSASVWDRISKWVSENKALVYTIAGVAVVVTSAGVVYYLSDSGRTTPAPSTEKKKSKNQRRKEKKKAEEEKKAKAASVQEEPAAKKTEEATEELPEVDEESVAQLSEETRKAYAAKLKAAGNKAYGSKDYNNAIELYGKAILCKPDPVFYSNRAACYNVLSEWEKVVEDTSAALAMDSEYVKALNRRAIAYEHLEKFSEALLDFTASCIIDGFSNEISRVALERLLKKVAERKGKAIIEAKGKKLPSPTFVSNYLQSFRPQALPEGLDESADLSDDSGKGQLRKGLLAMALKTGDGYEEAASAFEKALELGDLGEYEALALNLRATFTYLEGNAQAALLDLNKSVELQPSLVQSYIKRASLHLELGNKDAAADDFELAITHNKDDPDIYYHRAQLHFILGEFAEAAKDYQKSIDLDRTFIYSHIQLGVTQYKMGSVASAMATFRRSVKNFEEVPDVYNYYGELLLDQQNFSEAIEKFDKAVEMEKQSKPMGINVLPLINKALALFQWKHDFQEAENLCQKALIIDPECDIAVGTMAQLLLQQGKVSQALKYFERAAELARTEAEIINAISYAEATRTQLEVQEKYPQLAARLQGMGAGFAPPPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQL1</accession>
    <name>A0A8G1VQL1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD binding domain of 6-phosphogluconate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_447920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516805.1">
        <property type="nucleotide sequence ID" value="XM_025659811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQL1"/>
    <dbReference type="GeneID" id="37163213"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="6">
        <location>
            <begin position="183"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH58883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="327" mass="35329" checksum="E2E783088C53FE55" modified="2022-01-19" version="1" fragment="single">MDPSTNLHPRFGWIGLGSMGQAMALNLQAHLSHINAPSLKFYNRTAARGLPVHEIGGVQYPNIPDLMANTDICFIAVTDDTAVRSIIDTITTVGPEYLRQKVIVDTTTVHPDTSAWAKQRLGEHGATYIASPVFGATPTAQEGKLLFVVAGADEAVQRVEPYIVGIMGRKMMRLGEDVTRATLLKCTGNFLIGGMMELVAEAQVLAEKSGLGSEVLEGLLEEQYGPLLTSMSKRMTGGFYLPARGQRPWSDVNLAIKDVSLGVNCAEGAGTDLPVARVVLDHLREARGYAEENGRALDSSSMYGVLRERAGLAFESERVKQRDAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR06</accession>
    <name>A0A8G1VR06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_485131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519322.1">
        <property type="nucleotide sequence ID" value="XM_025663302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR06"/>
    <dbReference type="GeneID" id="37166704"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF242">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="97"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="347" mass="40050" checksum="1AF83164C04F2180" modified="2022-01-19" version="1">MANQAPQNRNARNQLVQNQPIRSQTTPNRLRWWSWTDLRIRQHRILVERHYPMPEGGPAHAKGTIEVESRQTGRIIRVNWYCGMDNTNAAAPVIIHLSGRNFCVKSHGIDDEFLHIVARENSPFIVLDVEYRIAPEYPYPAALEDIQDVLQYLRRHPADYDLNHLAICGFGAGGNLALAMALSSPRDTFETAVVFYPVTDLSYPEKRKIQLMEPDIRRRMRRGTGGVMPPWVMESTIQSYLRGNHPNIVDDPRLSPIRQQDESRFPRRLLFITAEGDPWTADTKTMVDGLIYARRRDPTSLPTVFYLEMLGVGHAWDKYRKLDEHGLDQKNTAYDTAARFLRREVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRB1</accession>
    <name>A0A8G1VRB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_412258</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519594.1">
        <property type="nucleotide sequence ID" value="XM_025657559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRB1"/>
    <dbReference type="GeneID" id="37160961"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF44">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="491" mass="55879" checksum="65EFC05A9EA07DAF" modified="2022-01-19" version="1">MSTPGRRTHQGCWTCKARRRKCDRARPTCQVCAQRGVACEGYDVRLRWGTGIASRGRFTGADAPAESSIPPRLQGRQRDLLRERKRQLQVADQVRKSSGSDISAEGTEELLLSPLLSETWKTNRYAELFSDFLSSGINVLHSTTMHDGEIPLKVRLPGLCQQSEALYQICITLQVSIRPDLKSEFFEYFDAALNKFRSELDQSEAYLEDGTLTAGLLLCTIGIMQGIPWTMHLRGMYNILQSHSVIRSHDQVSPFRAHLLEVMGIMDLPTFAIGRKHPYLGFWRQYCRNQSMPDPSEQYDVEVMSGLPRSLVDIFSCIYQGATEQDFWDWPGSRGCFMQCQLWEAYRLAGMLVIRHGAMRLPFELDDNPAQRGRSQRQSALPTTAVIIMRLLSCVDAIYRASSEAEGKVTLIINAIPYPVFVAGLQTDALNKDPDLREFIRRILVAIAEGPFWNKQYRLLLELLEEYWTYPQNTINIHQIAQSRGIELGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRT1</accession>
    <name>A0A8G1VRT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PHD finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_456242</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520162.1">
        <property type="nucleotide sequence ID" value="XM_025661431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRT1"/>
    <dbReference type="GeneID" id="37164833"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031213">
        <property type="term" value="C:RSF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028938">
        <property type="entry name" value="Rsf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296:SF3">
        <property type="entry name" value="DIKAR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="431"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="495"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="544"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="291"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="640"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="719"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="740"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="809"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH62240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="848" mass="95868" checksum="44869E98620179BE" modified="2022-01-19" version="1">MVSRKRTRSEVDAAPEQPPEEPGLLQQLRNCWEFASLMQYIAIFGKVMKIDEDFGIEDLETECLKPTPSEKLLEIGLCLLKWVSSHRGLTFDNFDEYTRRQYNAKAPHIPNPFGYEEVPNRFLDFDVFLKLRVLHQLSIWTFWNPDRIREKMPEQRELDQTEWRIEEIGYDREGRYYYILDDNRLYRRTDPPIPPPKPAKLKSRRKSARAMRASKRRRVTGADPIEESDEEDNAVDGDSSEDPLQAMTWECIAVTLDDYKQFLESIRKTRDPNEKILRDRIDEQVMPIIEKEEEAQERQKQKREKELFNMQLLAGAKRSSRIAGKAERERQEREAAEAARKRETELAAARKEEERVKKLEAERRSRIMTREQRTKDRERKRILHESELQRIKEEQEKVARGESRASERHLQAEMEKYRKNLEDLSQEDQWIFDCSGCGVHGQNLDDGSHSVACESCNVWQHSKCLGISKSEAEREDFHFVCKDCKRREEEAKLPKLPPLKFRVGSSTSPSSTAPEGDTKIKVPDPDQSPISSIKNAQHTFQLPLAGSPQKQPSSMPSVPSQNPPQAVSFPPLSPERRPQSAHTTSFSPPRAPFSPSKGLNGFTPSSKEQVPKLPSIHQAMHLPPHSRESFNGGSFPARRPSSSHSTQSPTLPSPIQNRPSMSPTQGNRDVGPLAGFPPVASTDHSAPWTPYGQHQTPRPNTGNHSSFSSLHNGRPSFMATPTASRSSPPQSSHGMPLSGISPTKQSPRPMTSGSVTGAPVLPPIQKLEPSPKLMGRSSPDAPIPPPVKCMTPEQEERRQRENAMLQAQLHGTNGPHSVMSSPSLNRIPPLGPPAVAQQPAPSPQPGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRY0</accession>
    <name>A0A8G1VRY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peroxin-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO85DRAFT_445799</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520297.1">
        <property type="nucleotide sequence ID" value="XM_025659356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRY0"/>
    <dbReference type="GeneID" id="37162758"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16527">
        <property type="entry name" value="RING-HC_PEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000395">
        <property type="entry name" value="Putative Peroxisome biosynthesis protein (Peroxin-10)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="327"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RAH62375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="378" mass="42514" checksum="99CD010178B0398F" modified="2022-01-19" version="1">MADEDLSLTTSAPTPSVSPSAHFYPFATSPDIIRSHEKDVFMTGSLTSRAHSIVRSLRGARYAHTHSDAIKHLTEILYFALTTFIGNRTLGEEYCDLVQLEDDTLQLPSLPRRAGYILSSILLPWTLQRILPAFRQRLRSKLERSIARQQFKASQAKKTTVEQAKDNKSSKKPSFFTKLRIQKYILEHLDSITSLSPIYAVSIATFYFTGAYYHLSKRFSGLRYVFTKKVEEGEQRVGYEVLGVLLVLQIAVQGILHIKKVGADLGQENEDTGLEADAGMKQYGGSLIPSLENPSSLPLLPASAARYDFSEDSHAIPWIPEGQQRKCTLCLELFKDPSVTTCGHVFCWTCVRDWVREKPECPLCRQEVLLSKVLPLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VTH4</accession>
    <name>A0A8G1VTH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_117547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519730.1">
        <property type="nucleotide sequence ID" value="XM_025653884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VTH4"/>
    <dbReference type="GeneID" id="37157286"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="94" mass="10995" checksum="8C73EF7DE725FE20" modified="2022-01-19" version="1">MFGISHSGFVLCTWGGSCANISFYWGLFFFSLNLFHKVSFLVSFFFLLFSHLLFSVRDIFGSGLRRSRTVFHCLFCLYQLPFLRLILLFTGVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQE8</accession>
    <name>A0A8G1QQE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTP-binding protein Obg</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_384167</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825085">
        <property type="protein sequence ID" value="RAH52361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510283.1">
        <property type="nucleotide sequence ID" value="XM_025656540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQE8"/>
    <dbReference type="GeneID" id="37159942"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.210.12:FF:000001">
        <property type="entry name" value="GTPase Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="6">
        <location>
            <begin position="80"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="307"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="559" mass="61516" checksum="9BE737329FD02D16" modified="2022-01-19" version="1">MAAHRTWLLRSIPRILPPNPSVRLRPLARTPAYALKVWSQRYNSTEAESKRSEYHQQTPLPDHISEPSHLNPSPEDYSRFIFQDKCRSTIYAGAGGHGCVSFLREKYVEEGPPNGGDGGSGGSIYIQAVEGMTSLHKLARRGIIKAGRGKNGQGKSKGGKRGNDVLLQVPVGTVVREVDRYDPVTEEIVRRKQEGAEERDEIDELGLPSIRHDRWVLYPGANPSDYLTTVFPNNPPRRQHIAALEPQAPIYLDLSQHMDKPILLAAGGAGGLGNPHFVTRNMNRPTFASRGEGGMRLELEFELKLLADVGLVGKPNAGKSTLLRSLTNSRTRVGNWEFTTLSPNIGTVVIDNHKGRPLVESKGKARRTNFTIADIPGLIEDAHLDKGLGLGFLRHIERAGILAFVVDLSAGDPVQGLKGLWHELGEYERVRDVEESMKVEGDDLTWNPPTHGLPELQSESAIQELNKVASKAKDELPALNLSPIHTKPWFVVATKADLPETQERFKTLRDYLAAVKNGEEEHPGGHPYGRRDKVCAVPVSAIRGEGVAGIPKLVVDLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQK7</accession>
    <name>A0A8G1QQK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidase FUB9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Fusaric acid biosynthesis protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_507275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510373.1">
        <property type="nucleotide sequence ID" value="XM_025664394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQK7"/>
    <dbReference type="GeneID" id="37167796"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="310"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="333"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00083297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH52451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="391" mass="42380" checksum="BD4BBDCFFD910917" modified="2022-01-19" version="1">MANRGKSLDSEIFSIADLQAKASEKLPRVFKEFFNEGAMDLITVKDNEDAFNRYKIRPRVLRDVSNLDTSTTICNTKVSFPFGFAPAATHKIAHPDGEIGTSKVAAEANICMALSSHATCSLEDVIAEGSGNPYMIQFIILKDRNITRQLLERAESETHRFVSLIIAGAKSSYVTGSGYKAVMLTVDAPMLGRRLNEYRNSFGIPKGMGYPNLAPGSDMSNLTETGEGLAYEDGIEWAEAIAWIRSVTKLEIWVKGIYTAEDVALAIQHGVNGVLISNHGGRQLDGVPATLDALRECASVAKGKIAIAIDGGIRRGTDIFKALALGADYCFAGRIPIWGLAYRGTKGVELAVKLLQEEFKLAMCLAGCKTIKDINKSHLSILETNGVLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQR4</accession>
    <name>A0A8G1QQR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_409005</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509801.1">
        <property type="nucleotide sequence ID" value="XM_025657426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQR4"/>
    <dbReference type="GeneID" id="37160828"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="17">
        <location>
            <begin position="318"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="502"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH51879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="538" mass="60848" checksum="B7B9CEA72A0DA507" modified="2022-01-19" version="1">MVDKRARHDAQQEAKRRKIENGEEVRAPVYATQFSQEDIESEQRRPKKKVAVLLGYSGTGYKGMQLSETEKTIEGELFAAFVAAGAISKANATDPKKSSLVRCARTDKGVHAAGNIVSLKLIVEDEDIIQKINEKLSSQIRVWDILVTNKSFSSYQLCDSRIYEYLIPTHCFLPPHPSTYLGKKLVEYAEKEGDMEGYKARQEEVASYWEETDEKYVRPILDNTPEDIRKLVEKVLHLNDEDRSAQDDMFQTQDKPASEETTEQPSTEEKPAAAENDEAEEARRRKVFETVKAIKAAYLQAKRAYRIPAQRLARVQEALDKYVGTNNFFNYTIQKTHADPSSKRHIKSFKMAEQPIIINGTEWLSLKVHGQSFMMHQIRKMVAMAAMVVRCGCDPQRIVETYGANKIAIPKAPGLGLLLERPVFDSYNRKTHETGKDPIDFDKHADTINEFKQREIYDRIFREEEETHAFSAFFGHLDHYSQEEFLYVTSGGIPAARLVSVPANGTEEKKSQREALAEVEGAASEDEGAPPNGGEEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS23</accession>
    <name>A0A8G1QS23_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-induced protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_492908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="GeneID" id="37167207"/>
    <dbReference type="Proteomes" id="UP000249526">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF4">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
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    </dbReference>
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        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="30051" checksum="7DD780A1D8FA3A32" modified="2022-01-19" version="1">MSSAATYTTFHEGIHSPDVKASTKILSPTTNLAPKTLPYWLVNVPRSQWTAECPSYLRDTSQKNIEVLSTPDEQYRRQGWELVKEIVRSNQIDRFQRLPSDLRRYLEFKEQIVAEYGSVMRFVVKERLRWGEGTADDLKPKGRPFEYDEDIRILYNDWPYGVEEGIVHLVVWTKFELEDDPVTDDLTPRARQEIEEYVQRTFLSRMPADQVIWFKNWKSLKSVHAVEHFHVMLHHPDAEFLREITGGDAPLKRQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS45</accession>
    <name>A0A8G1QS45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_492394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025663773.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="37167175"/>
    <dbReference type="Proteomes" id="UP000249526">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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            <end position="93"/>
        </location>
    </feature>
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            <end position="203"/>
        </location>
    </feature>
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            <end position="77"/>
        </location>
    </feature>
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        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH53291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="222" mass="23882" checksum="81CE8DFA7D598A83" modified="2022-01-19" version="1">MQKSHSYVLPPSATYNNVTGLPHAMPSANPAAERRDSTRSVMLTDVPALGDCPLVDDSSLSHRNSISTTDGISNDSPASWDGDAPSDNSPSAEVDVKIQDGLHHPFPTTADTSPKTFRFNVIASHGMEASMDEVTPKIEEIDDVDELQSIKPVGVETSMAHASSTHPDSTAAPVNVPRKRGRPRKHPLPAPGNQIKITKGRSKTGCITCRRRKKKCDETKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSU6</accession>
    <name>A0A8G1QSU6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_454253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510119.1">
        <property type="nucleotide sequence ID" value="XM_025661239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSU6"/>
    <dbReference type="GeneID" id="37164641"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="52" mass="6041" checksum="6B97A85E79B93DCE" modified="2022-01-19" version="1">MVSSKFLELAPCVPVWLSSWFQDRVGRPWLCYSVAQGNQSFQRFTIGVFRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTD8</accession>
    <name>A0A8G1QTD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_160566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511159.1">
        <property type="nucleotide sequence ID" value="XM_025654229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTD8"/>
    <dbReference type="GeneID" id="37157631"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="103"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="182"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="301" mass="35451" checksum="4A1D5A25BA642656" modified="2022-01-19" version="1">MTEVSSTRLYLGNLPRNVTKQDIEEHFSTHGSGKITEIKLMNGFGFIEYEDAMDARDVVPAFHGSDFKGERLTVQFARGPRRKENFPGPMDRPNMPRPRRTIFRMMVSGLPETSWQDLKDFARQSGLDVVYSETGRELGRGFVEFETANDLKTAIEKLDGREFKGSRVTCIADIQTYPDERAIRDPYRSRSPRRSYPPMDEYDRRFPAPRGYSPRAHYRERSPIPIRRDYYDRDGYGRRTPPRPRMEDYPPPRRPYDDPYDVRPPPPPRHYDDPYAPPRPYGRPRSPPRGEYMPYDRRGYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTM6</accession>
    <name>A0A8G1QTM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_203590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825085">
        <property type="protein sequence ID" value="RAH52364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510286.1">
        <property type="nucleotide sequence ID" value="XM_025654560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTM6"/>
    <dbReference type="GeneID" id="37157962"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="152" mass="17302" checksum="9993F819FD9535F6" modified="2022-01-19" version="1">MLLLYAQCERYIFPRSIIIANQDTPGQYYLSIDGRLHQHLPRNHAIPVPKMPKGSSLLTQRVLTPNLISSWPFNGGVTAPPSNLLRMIHSIANQQRPYRAIIFENQDNLSLWKLIAMGPEFGVFPKFGKPENSSVTPDHEFERARTTIHTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTU8</accession>
    <name>A0A8G1QTU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_523401</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511665.1">
        <property type="nucleotide sequence ID" value="XM_025665345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTU8"/>
    <dbReference type="GeneID" id="37168747"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="42"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH53743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="442" mass="47471" checksum="98631978615D21C2" modified="2022-01-19" version="1">MASTTACESISLTEPGERPISMVPEAPHNDSSVTEAKVPYLKLIASGFSFFVAGVNDGSLGSLLPYVLETYHVSTGLVIIVYVTTLVGWLVAALTNSTACQYLGLGSMLALGAALQVLAHILRAWLPPFPLYAITFFLASLGQAFNDTHANTYVAAVKAAHRWLGFIHAMYMAGCLVGPLVATAVASANRQSQWNLFYVFPLGLGLINLILVLVAFRDSMSVHHSSEAVQSDDPRASGQNSRGTRAVREIKDTLRVPAVWLTSLYFFFFLGAAITAGGWIVEYLVRVRHGDVHQMGYIPTGFYGGAFLGRLVLAEPTYRLGERRMIFIYAALCAGLELVFWLVPNIGVEAMAICLLGFFSGPFFATGISVASKIFPANIRSSGIAFVFVLGQIGGSLFPVLTGIISSHTGVKALQPMLLALLCATGISWLLVPTKAPRLRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUD3</accession>
    <name>A0A8G1QUD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_503521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511920.1">
        <property type="nucleotide sequence ID" value="XM_025664231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUD3"/>
    <dbReference type="GeneID" id="37167633"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="1">
        <location>
            <begin position="173"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="327" mass="37343" checksum="199BCBA806678262" modified="2022-01-19" version="1">MHALRPASPLHQLESSHVSESYHKKRILDYINNINPAHWPETDITIPSSSPSDRHATKSRNLTYADGLAYREALISRKINVVGEIPPSYGEPNPDYELPSTLTAPTEVENSLRHAYLNRIRAVGLATLRLSMPFFVTEWLIDMPELKYHVSMHFKTEPLKPQKTMLRPLNISDPDIVVGYNWKSIRGDYKLAFDEVPDSLRFAFPIVLDTHFAFPFFSIEMRSDAEQGPSRNLHLAALMLRGLGYFHQKAYGKNDEADKFDGKVRVLTATISRNDVNVFGHWTNGDPGDPKKEEFYAARHGLETLCKWMMKENRKWIAPGLQELAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV06</accession>
    <name>A0A8G1QV06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell differentiation and development protein Fsr1/Pro11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_380151</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512081.1">
        <property type="nucleotide sequence ID" value="XM_025656368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV06"/>
    <dbReference type="GeneID" id="37159770"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="6">
        <location>
            <begin position="35"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="751"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="581"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="583"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH54159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="830" mass="89912" checksum="B54E1308C8359731" modified="2022-01-19" version="1">MAWQSPSAMAGGGGYVGPGGDGSSNGGHPQGTEYTLQGVMRFLQTEWHRHERDRNAWEIERAEMKSRIGKLEGDVRTSKRLHESLGKHVRLLEAALKKEREKVKKLSNNEKVEDTRDPKEIAKESINSLKAQRPKPHTGPSEVDVNLENEHEYRQENEREKSRLYLSKCSQEVAYHVIPSSHPPPELGEQDLPNHIYGNQQLSQQSLEEAYLQQQRQKQHHQQQQAQANDMMAREVALQNHQPVITHYADNAAMSRAQNQFGFPPATREAMERRPLEPQQTPLTAIDNRKQALGNSLMEERAGQGDQAYDGYGSQSAAKDAKQQRMEEQGGDDADGWNFDEPAEPAPQAEQVPPHRPDVDAFPNANFVSSKSPQRSGSLSHRRKSSGARRKSDGAVDLAAGPKPDPTFKVRFALRGHLDVVRSVIFTGGGSPSEPEICTCSDDGTIKRWIIPATYGTFGASSSDLDITSYFTHRGHVGAVTALAACSPQNFSNGGRALGDGWVFSGGQDTSVRVWERGRVDPKATLDGHTDAVWGLCVLPGTAGSVLGESSSHYGGPDRILLASGGADGRIIIWAVSAPPQLSSPQAGSRRAGGSRRANSISSGSNFPSSPQPSTATTTPFHYSMVRQIVRTESPSPTCISPLSLAGINFVVSYTDASILVYDTRTGEEIVGMASLETYDGTPSTGVNSVVATTVGFDGSAGLDPSRTMGEEEVVHGATGSSGVEGVIISGYEDRYIRFFDANSGQCTYTMLAHPSAIASLSLSPDGRELVSAGHDASLRFWNLEKRSCTQEITSHRLMRGEGVCAAVWSRDGRWVVSGGGDGVVKVFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVE2</accession>
    <name>A0A8G1QVE2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">DNA excision repair protein Rad2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_427660</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512475.1">
        <property type="nucleotide sequence ID" value="XM_025658168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVE2"/>
    <dbReference type="GeneID" id="37161570"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000092">
        <property type="entry name" value="DNA excision repair protein Rad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000025">
        <property type="entry name" value="DNA repair protein RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000061">
        <property type="entry name" value="Single-stranded DNA endonuclease (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="14">
        <location>
            <begin position="810"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="536"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1019"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1075"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1022"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1126"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH54553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1138" mass="127577" checksum="7B24A1D167588130" modified="2022-01-19" version="1">MGVHGLWTVVHPCARPIKLETLNKKRLAVDASIWIYQFLKAVRDKEGNALRNSHIVGFFRRICKLLYFGIQPVFVFDGGAPVLKRQTIANRKKRREGRREDAVRTAGKLLAVQLQRSAEEEAAIRRRGRAENEEEVPDNPVYVGDAFITEQEKKQTRSFKKKDAYHLPDLQTSLEEIGAPNDPRIMSQEELEEYARQFHQGEDINLYDFSKIDFDSPFFVSLPATDRYNILNAARLRSRLRMGYSKEQLDSMFPNRMAFSKFQIERVKERNDLTQRLMNINGMNGEDALYKSGHRIAGERGKEYVLVKDDTIEGGWVLGVVGNKEGQEDKPIDVDQYGQQLIFPDKEDNSDDDDGGFEDVPIEGLNRLPKLPSLQKGVFDKFSRNQMRDSLDTGGPELQEVNDDSLFVEGGQNELAKHNHHTTDTLFDSTGDDDDETLQRAIAMSLQSGVGADADTNDDDLPEIQLNQNFMPPTIHEAPADLTDHSDDEGMDFVAALAQSKRVKKAPPKVAGNPFDGPLPFESLKPFKAGKLINRDKSAEQEAGATKSDNGSSKTKDIQILPPWFSGPSQSVKDAEFVSDEVQHRPVMKPPSEQDVPDHVFIVGDEETMGDHDSGAPKGSKPFIDLEPTPQLNGGGQESQIKLEVGPQVTPVEAQATETKDAEALEAHTGDIIAVDASNPSMTEKHISIDDETDLRHPEMSPSPEFEDVVIQQDNIPTEPTTLDQSDQVEEYYDDDNFSDPEDEQLLEQLAAEGEEHVRFAATLNSTSHTELPFDYEQELRQLRSQQKKDRRDADEVSQVMITECQQLLRLFGLPYVTAPMEAEAQCAELVSLGLVDGIITDDSDVFLFGGTRVYKNMFNQSKFVECYLTTDLEKEYSLFRTKLIRLAHLLGSDYTEGIPGIGPVTALEILTEFGTLEEFRDWWTQVQTGLNMGNDSHAAFYKKFKKHATKIFLPPSFPDPRVDAAYLEPEVDSDPSPFQWGVPDLHGLRDFLMSTIGWSQERTDEVLVPVIRDMNRREQEGTQSNITSFFSGPQGAGAFAPRVRSGGQTRMEKAFSRLRQQAVSVEQADSIGIDSHLHDPAADGSLESPVPSNLATGKETRPKRGRRGARNAPDGQDDMAERTATNKKRRTRRQVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVM1</accession>
    <name>A0A8G1QVM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhamnogalacturonan acetyl esterase RgaeA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_491210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512411.1">
        <property type="nucleotide sequence ID" value="XM_025663701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVM1"/>
    <dbReference type="GeneID" id="37167103"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01821">
        <property type="entry name" value="Rhamnogalacturan_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034354013" evidence="3">
        <location>
            <begin position="18"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH54489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="260" mass="27621" checksum="6451C1EC9519EB1E" modified="2022-01-19" version="1">MKVSSLPILTFLPTSLATTIYLAGDSTMATGGGGSDTAGWGDYVAQYLSNSSGITVSNQAVAGRSARSYTREGRFDDIASTLEAGDYVIIEFGHNDGGSLSTSDNGRTDCSGTGSEVCYSEYDGVNETILTFPAYLENASNTFKKIGATVIISSQTPNNPWETGTFVDDPPRFVGYAEIAADTADTSYVNHFDYTDQVYEALGADTVDAYFPIDHTHTSAAGANVVAKAFLRGVVCGKLSLADELVTDDLELDEYECLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWK0</accession>
    <name>A0A8G1QWK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Patched sphingolipid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_451543</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513120.1">
        <property type="nucleotide sequence ID" value="XM_025660612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWK0"/>
    <dbReference type="GeneID" id="37164014"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000008">
        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000029">
        <property type="entry name" value="Putative Patched sphingolipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034848452" evidence="13">
        <location>
            <begin position="22"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="604"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="641"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="723"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="748"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="832"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1071"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1104"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1133"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1176"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1217"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="14">
        <location>
            <begin position="599"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH55198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1277" mass="140353" checksum="D9C013DFF928AAF8" modified="2022-01-19" version="1">MRGLRLIPFIASLGVLPQSWARDEPSLGFTNIHEPGRCAIRGHCGKKSFFGGELPCPDNGLAQEPEAAVRKKLVDLCGSKWEEGPVCCLDEQIDALSKNLKLAEGIIASCPACKDNFFNIFCTFTCSPDQSLFVNVTDIDEARGGKQLVTEIDNIWSEEYQSGFYDSCKNVKNGASGGKAIDFIGGGAKNYTQFLKFLGDKKLLGSPFQINFKTEPAGPDPEGMKPLPIKPKACNDADEAFRCSCVDCPDVCPELPAIETDKYCHVGLLPCLSFAVILIYSVFLLVIVAFSSYFTYRERRYRKPERVRLLQDPAPSDDEDEGDIVRAGGYIEQPNGVYKLNSMLDRVFNSNGGACARFPGLTIGSSIVMVVLLSLGWFRFAVETDPVRLWVSPTSAAAQEKAYFDANFGPFYRAEQAFLVNDTSSGDGSVLSYDTLSWWFDVESRVHRMISLDRGLILDDICTKPTGEACVIQSLTGYFGGSVANLDPDTWEARLKHCADSPGDVSCLPDFGQPLRPEMILGGYGESRDVLDAQALITTWVVDNHAQGTEGEANAIDWENSLRRILEVVQEEAKERGLRVSFNTEISVEQELNKSTNTDAKIVVISYIIMFLYASMALGSVTVTWKSLFTNPANALVQSKFTLGIVGILIVLMSVSASVGLFSAAGIKVTLIIAEVIPFLVLAVGVDNIFLIVHEFERINVSHPDEEIDERIARALGRIGPSIFLSSLTETVAFVMGVFVGMPAVRNFAVYAAGAVFINAILQITMFISVLALNQRRVESLRADCIPCLTVRKAHSGMSEDQLLDHQEGESALQVFVRKVYASSLLARRVKVIVVITFLGLLTAGLALIPKVALGLDQRIALPSDSYLIQYFDDLNAYFGSGPPVYFVTRNVNVTERHHQQQLCGRFTTCEEFSLPFVLEQESKRSNVSYISGSTASWIDDFFYWLNPQQDCCKEDGEICFEDRTPAWNISLYGMPEGDEFIHYVEKWIESPTDASCPLGGKAPYSNALVIDQKRIMTNASHFRTTHTPLRTQDDFIKSYISARRIADGISKEHGIDVFPYSKTYIFFDQYVSIIRLTGTLLGFAVAIIFALTSTILGSVATGAVVTTTVVMILVDIMGAMAVAGVSLNAVSLVNLIICVGIAVEFCAHIARAFMFPSRAIMEKVPTKFRGKDARAWTALVNVGGSVFSGITVTKLLGVCVLAFTRSKIFEIYYFRVWLALILFAATHALIFLPVALSYFGGEGYADPGADGGLEENLASRGYRSLLGDDDYDSDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWM1</accession>
    <name>A0A8G1QWM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_498973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513150.1">
        <property type="nucleotide sequence ID" value="XM_025664043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWM1"/>
    <dbReference type="GeneID" id="37167445"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH55228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="623" mass="69577" checksum="159DB5ED000DBF5E" modified="2022-01-19" version="1" fragment="single">VTETNMEEHSQAKRRKVRKGTRSCWECKRRKVRCIFSSYSNANCDNCSRRGSKCISQELPDSPMPTSKDLVDARLDRPSPENNIPAGPYESINRDLLAAWPSQRELNHIYNLPVGISVYMNYEIWVPNSLSADDKLPTPQEMLQLPAPSSHPVLITRKLLTLAIFLQGIPPSSIQTLSNLSISYHDIMTRAVTRATRLVTTNDELTPSIEGLQCIMLEAQYQNYAGNLHQAWLAIRRATAIAQMLSLHRGLPASSLKTLDPATRNTLNPDYLCFRLVEMDHYLSLMLGLPPTNLEPRCLSPKALETCTPQDRMHRMHCIVAGRILHRTEDDINNLSLTNDIDQMLQNAAAQMPPQWWLIPDLTPNQTQATIIQNTLRLNAHFTHYQLLLRLHLPYLLRSPQDSTAYDQSKLTIITVSREILARYIAFRSSNPAHYYCRGVDFIAFVAMTVLCIAHIDSSSHLHREKQGGIGIVVSFLAHSRPSDRGMMERTLSIIEDMVESGSGTDEIAGKLAGIMRHLLGVEESAAGGVGYVARENMGEDGKGGREYDGRVGDGGRSLHVYIPYYGTIGFERSEKEDIGSGGIGGSEEWDLHAVDVALFNSLFGDMGVPDIGEEGWEDWVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWM5</accession>
    <name>A0A8G1QWM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Small nucleolar ribonucleo protein complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_87336</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512854.1">
        <property type="nucleotide sequence ID" value="XM_025665751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWM5"/>
    <dbReference type="GeneID" id="37169153"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000657">
        <property type="entry name" value="U3 small nucleolar RNA associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000743">
        <property type="entry name" value="U3 small nucleolar RNA associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="9">
        <location>
            <begin position="355"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="417"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH54932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="447" mass="50886" checksum="38051843B534B80A" modified="2022-01-19" version="1">MKIKALSRPTSSQQAPGTAVVRQPRNLDPAQHPFERAREYTRALNATKLERLFAAPFLGQLGQGHVDGVYTMAKDPGSLERFASGSGDGVVKVWDLTTQGEIWNTQAHDNIVKGVCWTPDRKLLSCASDKTVKLFDPYNSAPEAPPLATYLGQGAFTCLTHHRDMPYFAASSSQISIYDLSRPSSTPSQTLHWPTDVDTITSIAFNQTETSILGSTGIDRSIIMYDLRTSSPLHKMVLRLASNAISWNPMEAFNFAVANEDHNVYMFDMRKMDRALNVLKDHVAAVMDVDFSPTGQELVTASYDRTIRLWNRSTGHSRDIYHTQRMQRVFSAKFTPDNKYVLSGSDDGNIRLWRANASDRSGVKSARQRAKLEYDQALIQRYSHMPEIRRIRRQRHVPKPIKKAREIKREELMAIKRREENVRKHTKKENLPKRQSEREKMILAKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWZ1</accession>
    <name>A0A8G1QWZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dopey N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_402048</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513095.1">
        <property type="nucleotide sequence ID" value="XM_025657177.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37160579"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="9">
        <location>
            <begin position="396"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="10">
        <location>
            <begin position="1365"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH55173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1853" mass="206165" checksum="7ECE459E40AEA59E" modified="2022-01-19" version="1">MSLDPSSFPRSNSPASSESSLTRSRLRGKEEPLKKDKNYRRYASTVERALSLFDTALQEWADYISFLSRLLKALQSHPADMPIVPHKLLVAKRLSQCLNPSLPSGVHQKALEVYTYIFNLIKPEGLSHDLPLYLPGIAPTLTFASLTVRPLFLSLVETYICNLEPWAIRPALKAILLALLPGLEEETSDDFDPTMRLVNKFRDIASKMDTYKQEAESSPSGHYFWQCLFLASITSPSRRSGVLAYLNRYLPKLGITDRRPSKSEVSEAKDLPHDISVAADSVILPEPGLLIRCFATGLADEQVLVQRNFLDLLVTHIPLSSPILQARITKDDLQKLILAAVGVVSRRDMSLNRRLWAWLLGPEPANDRPSFEARNSISDNASQPVPDAQEISHSEYFSRFGLTPLVNGLLGMIEKDTEIPAEKTRPFRISLSLMDRWEVGGYIVPEVFLPIMRSVQAFESKASKTQFEEVFRSASSFFDGVESGVIFSELLYLIDWKSKDLTSGHDKVLKNLELAHFILENFNVREEDMVLAHVPLLTLATIIKSSELSPEKSPNMDQERLRAVATGLSRVMTSLSGLLTERAFAKKSDTHKADGSKSDVPGSQILSRIHAFYEQSKQSLDPQPLPFAPKHLGELIIRNAYEQAIEALDGRGDATQMHERISLLIVMLKKLPKTKILRDRRLYLALCDRVRADQVETSTASFAAISSIASAITSMYFIHSPGYYISYEDVSDLIPTLVNRLWQYLSPLNPKFHVEAVRSLWHLHSVSWADHLVEAAITSLMVDKSNGHRQSSSAEQAGRYFVLWSHSHHGTYELPPKQLHNVSQLGISYQSSMLERPLFIVLDLLNQGVNEASQVVHRWLEDLSSIHKVFRMVVSRLDRLFQQSENAEPDTANPTVSPDDYRECSYLLQTISNLISTLSHNGWISLLTQTLVQTEKHKDTPTSEDNSGAQSLHAVIFQASLRVVSGHTTAAHQGVDEIKLQQTALLVMRQLLLGPGAEEVAESGIDSFLVDRLSSVLDNGGSVGIQAALIDTLLAALKVRFAHAYLPPPPPRPKHQRTASRERLTSPSILSFTSDKPDKSLALPPLPQPPQQLLECLLKGISSPNSREIVERWTILLCEVLPLYAGSIFQIILMLVECFCKEIQLAYASLQLSFKRTEGWPEDRSEHATIALLTGLETCIATAHERLLSEEANVPAAKSPDQNHGFFGNMVSGVFASEQSHARSSAANNRLTVLLCFQDAVRLCFSIWSWGALERSTLPQDPESLASFQYTSLRMRNRSRRILEHLFTAEALECLETAVEVWTKSDSDTSSLIISLLHTLDGSRPKITIPAVFNSIYTRTNPAALEPNRKSTLTASLTESELAGFLVTYARSLDDDVLDEIWADCTTFLRDVLSNPFPHRQILPRLVEFAAILGAKLENTSFGEDRRMRKELGDVLLRLLTAIFTSKPMGLSQESALLGRASIDYDSGSLPHVGPDDLLSILAASMPAFTTTLGDSDRITTAVSGISTHIIGPLFRARLFPNNVSRNFMALLQHIAKIPAASKIWKKDISDAFNDPKFFGMQLDLVKDGWVNLLRQWVLADKDRMSELMSRLTPPSTAGIMFGVGASAARLEADRKAQLNLRRISLLILSANTDYFVAELPALLQKLEDLLGATSSSSPSSTTRSEVFMVLRALALKCTATTLAPFWPLMNSELQEAISAVSVGQQQEVYNPYALLQACKLLDTLLILAPDDFQLLEWLYVTDTIDAVYPPERFEPMALADEISQSLGARGSASSDGLGETADLSQGVKQPSLTADWIRETAKDEIVERVLRPFFDQLSIHAFESTYSMGHPRLDVCRDDLLADLFNESTMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXE3</accession>
    <name>A0A8G1QXE3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">mRNA binding post-transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_491635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511832.1">
        <property type="nucleotide sequence ID" value="XM_025663727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXE3"/>
    <dbReference type="GeneID" id="37167129"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12611">
        <property type="entry name" value="RRM1_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12613">
        <property type="entry name" value="RRM2_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12346">
        <property type="entry name" value="RRM3_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000065">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000222">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000227">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="66"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="160"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="287"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH53910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="402" mass="42916" checksum="CA615E4C8F74F83C" modified="2022-01-19" version="1">MSFQNFDSFQNQHPAADAAAAAPGAPATADTAMTGQADPTTAPFQGPAPGEPSAAPVPQQANEGKTTLWMGELEPWIDENFVRNLWFQMGEQVNVKMIRDKFSGSNAGYCFVDFASPAAAAKALSLNGTPMPNTNRLFKLNWATGGGLADRSRDDRGPEYSIFVGDLGPEVNEYVLVSLFQSRFPSCKSAKIMTDPISGMSRGYGFVRFSDENDQQRALSEMQGVYCGNRPMRISTATPKNKGPSLGAAGAMGMPGPAGMYPPMGAPPMGFYGAPQPMNQFTDPNNTTVFVGGLSGYVTEDELRSFFQGFGEITYVKIPPGKGCGFVQFVQRHAAEMAINQMQGYPIGNSRVRLSWGRSQNNSGPAGSPYRPAPPPPPMYPSMGMPPAHGYGGFAPMKVGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXL8</accession>
    <name>A0A8G1QXL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone/menaquinone biosynthesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_429934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511152.1">
        <property type="nucleotide sequence ID" value="XM_025658272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXL8"/>
    <dbReference type="GeneID" id="37161674"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF83">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="334" mass="37262" checksum="B518562C8955F673" modified="2022-01-19" version="1">MSAPRVGRAALKKAKLPASASASKPAPRFPVADGTGPKTLPKRANQHLKDLPSTPPSAPVSPRIMTIFGVSALTLSTYIGYLYASYRREVTQSQSLSVPHDVSDRYNHTARTFDADVEMSEKVMRMGSKRADLISRARGDVLEVSCGTGRNLQYYELGQRRGLDNKGRVGVHGCRSVTFVDLSPEMVEITKAKFAKQFPEHEVPVNFEVQDAAGVSRRPVDPSRKGDEGYYDTVVQTMGLCSMPDPVGTLRHLGTVVEPNKGEILLLEHGRSHYDWLNRILDNLASAHADRHGCWWNRDIGKIVRDSGLEVVEEKRWHFGTTWKYVLRPARREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYL4</accession>
    <name>A0A8G1QYL4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BFR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_499286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513318.1">
        <property type="nucleotide sequence ID" value="XM_025664067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYL4"/>
    <dbReference type="GeneID" id="37167469"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="5">
        <location>
            <begin position="238"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="4">
        <location>
            <begin position="438"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH55396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="565" mass="61965" checksum="05A140CF6DEC80F7" modified="2022-01-19" version="1">MAPKSLAEQMAELEDLTPRDYDPEDLDRGNQDSDEEGAAGGKDENAGREHYQAVGKAKLRKQDPITLGKQYAGSKVSRAALEADSDDDPFAARSGDEDEDEDDDEEEDEDEDEDEDLELGSDEDDEDISESEEEEEEEQRPSKSAKKGKKQVELDDMDTDESDDLEGSEGSFDEDEMPSDEDEEDEDDDDEEEEESESESDFDSKSRKPTNDRDELRRLMATDQKTIAASISQAAKADAAKGKAVKQQRATFDALLNTRIKLQKGLTAINQLSLAATSPDADSEEAITSAESAALALWSTLEDLRVVLADAHNTNGSTEEPKKRKRVDTDTPTATLWTRMTDLESAATTHRRTILDKWSAKVRGSTATTAANTRGKLINSSGSGAQSITAVLDAQVATETGDHSRAAKRARQDTTTTTTTAAEGAAATTPIYDDTVFYQSLLRDLVEQRMASSDAITNGLDTLHIQLPTRGGAAIHPVTGMRKDKVKRDVDTRASKGRKMRFDVHEKLQNFMAPEDRGSWTKHAREEFFASLLGKTASGLLREESGDEESGAEEILVAFLFQEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYT7</accession>
    <name>A0A8G1QYT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_440340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513423.1">
        <property type="nucleotide sequence ID" value="XM_025658761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYT7"/>
    <dbReference type="GeneID" id="37162163"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="399"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="795"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="809"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH55501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="854" mass="93865" checksum="B4F0BB770B237DC5" modified="2022-01-19" version="1">MPHGQPPMPTPRRQQDVPYTAAPPNMRSPPAYMGYHPHMNGHPPPAAYSPQQYPQWYPPYPAMQLPPRPYQHPYGPMYVSAYPPSQPIMAPAHIPPVSLPMQPRTSTPLQSTMSPPVGLPPLPITTQAQSPATVPVHPAPSSVVSSSPAPAPAKVSPEPREPFRPPLPWLSVPDHPFPARIPGRRRKSRLLPTSSVSVELPTKDPHRADQPERQTEVQRLEPEQSPSEPQTPTLSAAPSVANSTQPTTPSSVAQNLPLRPQSQSKGAKPTIPVVPVVPVVPAPSTPRQATKDESTRSSETPKSVSGTAQEKTNEDTQELSQNKTEEPVKQASPAPAAPKSWADLVRSKALAKGASAPNASPAVSNGVIKPKSESLADVLTTLGDDVSQYSDKVAFLQPRGLVNTGNMCYMNSVLQILVSCVPFYQFLDHIGRRASHSFNSDFPMIDALIMFMREFRIIDAAHTEEQLKLRLKPNELEDYGEAFVPEFVYEVIRQLPRFRDMRRGHQQDAQEFLGFLLEEMHEECNRAAKDAPATTSASANPEAEVANEESGDGWLEVGHKQKAAVTRSSGHIALESPITKIFGGKIRSEFRVPGNKTSVTLEPYQPLQLDIGAPEINNIVDALKGLTKPESIQGDFNSSRGPNVTATKQIFIETMPPVLILHLKRFQYDSVTRGTQKIWKKVGYPLDLEIPREVFPPNKRNIMMAQGGLPKYRLVGVIYHHGKNASGGHYTVDVRRQDGREWIRLDDTLIRRVRSEDVAQAGGEEDPKVLAAALEQHKRDGPNANIFDHIDQDDLEQSDNERGWSQVNGASGHSSKKSTSGAASAPSSGVRTPLGRYGSRDNKVAYLLFYQRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZD9</accession>
    <name>A0A8G1QZD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_450568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514466.1">
        <property type="nucleotide sequence ID" value="XM_025660405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZD9"/>
    <dbReference type="GeneID" id="37163807"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="523" mass="59047" checksum="2A6A5B5A9E8A1A2C" modified="2022-01-19" version="1">MSHDPPGDPPMSHSPRRLRRLYEPLSLLQTLGNVRGWRIRAPDIPQDNSGFNAIKSHRSFVDALAYACAYKKEPAYVTAVALEKRPEEIVVWLAANKNVEEAVVSFAQDVLRIVQWLASNPSAQLGTKDGQQALNLLTSRVLRFNAPKIYAYYEQVVRAAPRVIAKLSNGQHEGNPNVANLKRWLSQHLQRDGVQLQEVDMANLAVISHNSRETFEVLRNLAMESHDPHTFERLFKLLGKLGKHVIMSKRIVEGAIFLRSDFARGMRLERVPASRERPLPFSSRKYNIDGISNRMFSSNSAEKQRFLARLRTIWDTNEWDKNLAKEHLAGKSIVHAELLILDHFEKTGGDFLDNSDKYIGCSKPACYLCYHYICNHPGRYIRPSSHQKLYMRWRLPDISVTESNAATRFTDQEQILNNLINLVRRELRNDIETGVGKMKECPDSTAGGTSTMFELETGLEADMGSLSFQELRHQIDPDFQYVVIPDPVSSSSSASSIHSRSSADTAVSEGDEVEYDSDGGVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0A7</accession>
    <name>A0A8G1R0A7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_401148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513826.1">
        <property type="nucleotide sequence ID" value="XM_025657150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0A7"/>
    <dbReference type="GeneID" id="37160552"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="312" mass="35638" checksum="1546AD61BA08D879" modified="2022-01-19" version="1">MAWGESKPIYRLSNNDKRMIIAGLDGFCVQDDWDSIYSSLPPGGRAEFGIVLLETMMNKFIYDKFAASTFWFMDAKMDAADQEGDDNFCKRLDYVYERFKEKWVSNPPPTPLLHATLERRKPLLKTYGDELLASQPFQLLFRGSLSEEDQAIREERTREVLEEAAHQFTSLQGDMFGNLVVELLPDLPTFDRHAKNMDHHILHVGFMPHHGARVLIVTRPHYSYHDIVATNGWQSRPPLQIVTARVLTAPKGPKARTRWAAAGDKPIYVAQGHTNTAEKEGVNQEEAVDEGSDGEYKPRKLRRTYLRGAEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0D2</accession>
    <name>A0A8G1R0D2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_522547</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512547.1">
        <property type="nucleotide sequence ID" value="XM_025665270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0D2"/>
    <dbReference type="GeneID" id="37168672"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000011">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000017">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF92">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="238"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH54625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="669" mass="75624" checksum="FBA03B24AEA800C2" modified="2022-01-19" version="1">MAVSPHPFDSISPAEIVLATKILAAAFPGVPLRYKKIDIQEPIKCEVVPFIEAERLGKPLPAKPTRLLLVLFHRMDTMAFCKALLNADTRSVISAKELPKHVQGPGDPDELGEVEQLCLSHPAVQAEVAKLKLPPGVTVCNDPWIYGTDDPNETRRLFQCYMYIVATDHPENNHYSVPCKFSPVFDVHKRELVRMDYLPGGVDMQTTETQPWKPVETIQYAHDLLQEPLRTDLKPYIVQQPQGPSFNIDGSVVSWQKWRFRVGFNSREGLVIYNLTYDKRNVFYRLSMSEMTVPYGDPRAPYHRKQAFDVGDVGFGVTANQLSLGCDCLGHIKYFDGYRADSKGNPVLLKNVICLHEQDNGLQHKHTNYRNNAATVVRNRQLVVQMICTVANYEYIFAFIFDQAANIELEVRATGILSTVPFDNEKPGTTVLWGTNVGPGVMAPFHQHMFSFRMDPALDGFKNTVYYEDSVPLPEDKNNPYLVGYTTEQTVLRTSGTANTDISRHRVFKIRNDTHINPITYKPIAYKLQTSPSQMLLSSPKSYGAKRAGFATKPIWITKYRDDELYAAGEFTNQSRESEGVEKWVQRKDPVENEDIVLWHTFGLTHNPRIEDFPVMPVERVSVMLKPDGFFIKNPALDVPPSTQSFNKSTLHPEPAATCCAPAERMGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R123</accession>
    <name>A0A8G1R123_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Meiosis specific protein Hop1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_489827</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513752.1">
        <property type="nucleotide sequence ID" value="XM_025663627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R123"/>
    <dbReference type="GeneID" id="37167029"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15558">
        <property type="entry name" value="PHD_Hop1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="57"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Pterin-binding" evidence="8">
        <location>
            <begin position="727"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="643"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="693"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="724"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH55830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="782" mass="88053" checksum="B887CEDEB349E47C" modified="2022-01-19" version="1">MVRIKFTGPPSTVQVQTPQNLQSLAADSKPVARIRAQDVIEASAILKLQESMHLQQLQSLEMVQIMLHVSFGTLFYLREFLPLPCFDDRDLREAQREGDLSYRQFIDKHTHREELASKEDVPFGRGKKGQPLKIILRGSDPKADMILDILETGIFDALSKNVLEAVQLTILVDKDAPENVLESYTFSFRYTRAKGDVNNCLESLSLEPMGCVADMKTAQTARIGLETIVRRLITLSAFLPTLPNKRSLGVHLFYTEDCPPDYEPPGFNGADDVTIKFPLSENWKRESQSCGQMNSGRHTVGLKVTSLKWTRAEPEGAEPLPQIPPDLEFNDPVRRTKDIGFDDKEDILRTLGGSGSLSMENGLRQDTDLCLSLCQKAENEKVSTQDLVDKHQLQMMLPSQGTEGSDGDLAPTQPLKPGTAFENGTATKCRKFVLTEESRHRIQEYLHSHDSTATRTTEGHNSVRCQCGWDGEEEAMAQCAFCQTRQHLLCYGYEDAHDPRVPDIHACYPCLLMPDEPHILHQMSSLVLLRRAVRIILNEGYPHRTSLFTQKLHCNGHTLVQIIDLLKKRKLLQPTPGSKAKGFSLKGLPRFMFPSSGDTQARLQAEILSPMIKIQHHYVQDIPQDSLQPSQVVTNDELHSITRSISREDELEESLLDAQEGGRKTPVPMEKSTSMVAETRSRKRLASLANEHSQPHTPKDTAHKDASPPRRVSDRVLRKDSRNQAEQQVKSIKNITPRSKQTPNRRISNEGSLRRSNRKRRKISNYSKLVDVGAEQSENDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R146</accession>
    <name>A0A8G1R146_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_514015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515240.1">
        <property type="nucleotide sequence ID" value="XM_025664726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R146"/>
    <dbReference type="GeneID" id="37168128"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034096817" evidence="2">
        <location>
            <begin position="21"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="369" mass="41155" checksum="D7EA48E0104DB9B9" modified="2022-01-19" version="1">MRVPGTMQAVLLAFIVEVAAKEDPDYKPSLNFRPNNVTLSILDNWVGSYYNGTTNVELSFYTGLGSNWSFHCPNLVNTTVTKRYDSTVLALTEPNTYNVGYDPVNAFFTMWPNNFNFSTLPGPSWDGLQEDASLKFAVFLSDNALPILQVIILHNRRKEEHWVKESILGPRDQFSRRLLPWLKQLFCAIAPENGAIMTDELQASTLLQLLEVLPDEALVDLLASHCPDCQLHDRWNHNILYALAHRPTAQALQLLKARNLLPQLDLNATDDYGWGPPARCGHPRLQRGRDLSSRARCRPPAAKRPIRDPSQARRDERRHPDHRNPRPLGEQPYRGSSSGLHGTARNSSADPPGDGVGVGIAALSLASIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R165</accession>
    <name>A0A8G1R165_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-glycosylation protein EOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_397118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516088.1">
        <property type="nucleotide sequence ID" value="XM_025657013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R165"/>
    <dbReference type="GeneID" id="37160415"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021100">
        <property type="entry name" value="N-glycosylation_EOS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147:SF1">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12326">
        <property type="entry name" value="EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="42088" checksum="DE40FAD09E027589" modified="2022-01-19" version="1">MKRENEAKEIPPSGPGGSDQRQFSSGPTTTTNSFSSDLPAAYSGNICVTAAYAGVLRLAPPYRDAASPSFSTSHARSSYPEPDLIASLSDSIPTTPNSSFYTTLASILSKVDSNDKAVAPSSAPSTVVPPSPASSTSPTPSINDAGHSVPSALHPRVAVILGVDRKWYLPLLICRALSTVPAAWWGLRCAFTFLAELLHIRPGIGHEGWAAAIVGSVSQDWDVERRFRVTEVALAIMWCSASAYLSYFFADCMMSRWLLNYTPPAVVIRLLTTNGLIAYITSWVLYLSGASSDPRCLLPAWISITTTLTFLYHATQNHATIKRETAAALLVVAVASFVSMSSLLLQLHLTRENEPEVPVFVITRKLWDWAVAIFLRMRVSDGRAPLGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R232</accession>
    <name>A0A8G1R232_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Activator 1 37 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_468497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515765.1">
        <property type="nucleotide sequence ID" value="XM_025662267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R232"/>
    <dbReference type="GeneID" id="37165669"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000007">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="60"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH57843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="352" mass="39069" checksum="1CAB39F509D46CA0" modified="2022-01-19" version="1">MVQAESSASASRNGLKAHTAGAPPDYELPWVEKYRPVFLDDIVGNTETVERLKIIAKDGNMPHVIISGMPGIGKTTSILCLARQLLGDAYKEAVLELNASDERGIDVVRNRIKGFAQKKVTLPPGRHKLVILDEADSMTSGAQQALRRTMEIYSSTTRFAFACNQSNKIIEPIQSRCAILRYARLTDAQIVKRLKQVCDAEKVEHNEEGIAALVFSAEGDMRQAINNLQSTWSGFGFVSGDNVFRVVDSPHPIKVQAMIKACWEGKIDAALETLNELWDLGYSSHDIISTMFRVTKTIPTLSEHSKLEFIREIGFTHMRILDGVQSLLQLSGCVAKLCKINMKPQLFEPPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2H0</accession>
    <name>A0A8G1R2H0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_478922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514502.1">
        <property type="nucleotide sequence ID" value="XM_025662920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2H0"/>
    <dbReference type="GeneID" id="37166322"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH56580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="332" mass="37511" checksum="4A0292D5D044109B" modified="2022-01-19" version="1">MGSHMSDRVVWVCLGVSLFFAVRGIVTDLRRVRELTEIKHVEKEDKMISEGTEDALNLDTLLKLSDSTSYDLRAAYDRHRMALRIIAERSTKGETRDLLLRDLATRNKQRRGKALTAMHFLVSNRALSRTSVCSRLKDPATYNALIDCLCILTDEHVEETTNTISPILPKTRPPGEKKALSILNIILQENVPAALEAGIVSRWLVNYPFPCALSEPSRRQDVVLLMKTWWMDDTVMSAIFGTLSSHPEGAKQLRKYGLMGSLMEENDQDDYDSDVWMVDGEDTAGTRRVPGRRLRTAEEQAVRRRRREAMVLSDGGRPLGNDDIIQLPVSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2H3</accession>
    <name>A0A8G1R2H3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_273436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516285.1">
        <property type="nucleotide sequence ID" value="XM_025655117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2H3"/>
    <dbReference type="GeneID" id="37158519"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000033">
        <property type="entry name" value="Clavaminate synthase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="370" mass="40050" checksum="8D83DDDA58765E21" modified="2022-01-19" version="1">MALNDIPVAQAVTVTLQDLIDGTIPPTTLTEAFGPSSLGIILVKNLPPTFPHLRAQVLSNASYLASLPPSTLESLTCASAKYLIGWSLGKETLRDGHYDTHKGSYYLNCAFYNDPSLQGAPSIDAEFPEYTSPNIWPSETDLPTFRSSFEQLCTLIIDTAALVARACDRFAVESVDGYKPGYLEKVVRGSFTTKARLLHYFPTEGSSSSSSSEGGKKEEEVGEGNDDDDDDWCATHLDHGCLTGLTSAMFVDEEAHDPSSSTLEDKSSPLPELMTSPDPKAGLYIRSRTGQVVKVNIPKDCLAFQTGEALQLITRGQFRAVPHFVKGARGVGKVARNTLAVFTQPNLEEEVQDGVTFGDFARGVVEKTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2M2</accession>
    <name>A0A8G1R2M2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fringe-like glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_292677</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515959.1">
        <property type="nucleotide sequence ID" value="XM_025655281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2M2"/>
    <dbReference type="GeneID" id="37158683"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="10">
        <location>
            <begin position="196"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH58037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="479" mass="54529" checksum="23B3FC4CA271B45F" modified="2022-01-19" version="1">MWAKPADKPRSSMGKRKLLRFVVISCIVTSFTIFLWPRLESERVTTETVSNITITSDVGCQPDFEALRRLNVQKLTQYVRREVVASQSPSNVLPLSQRLQVPLFPQKPHGDQLHLPEELLHEDCLIPNPVSLQVPTPPRHADASHIDFGVATTIERLNDSLDAFSHWAGYTNAHIFALVEPDERAHEVLLKADALGINLSISESSEEYQRRYFSLVPHLAKNARPETKWSCVMDDDTFFLSMPELVKGLKEYDETKPMYVGGLSESIPQVGVFGLMGFGGAGVFLSRPLIQELSRPEVFEDCQRMDVTGDRRISLCIYQYTSVRLTIDHRLHQLDMMGDVSGFFEAERQPPLSVHHWKSWFHADMAKASAVTEICGDSCLLRKWHFGDGWILTNGFSVVKYSSEKKPGDRSMELTWDSHNGAVFESYLHELGPLRLKDEGKISYLHEDAIIDGNRVRQWYVHRDPEQGDQVLELIWRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3M8</accession>
    <name>A0A8G1R3M8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_420213</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515819.1">
        <property type="nucleotide sequence ID" value="XM_025657888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3M8"/>
    <dbReference type="GeneID" id="37161290"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04105">
        <property type="entry name" value="SR_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH57897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="320" mass="34409" checksum="1DA49026C2797A29" modified="2022-01-19" version="1">MQSHANWKTLEGIATSLLDGSPIAIAVTVFIAFGLPILLHLIFYRTVASPPSSNFLLLGPSGAGKTALLSLLETKSSRVPPKDSRLTHTSQTSTVATISLPASIQTASNRYRSVNDTSLKDISKNPVKYRVWDTPGHGKLRGSQGLATLLSMSTSKDVKSKLRGVLFMVDTAALVEAETMRDTASYLYDVLLALQNRALKKGKNSAKAASEIPVLVVANKQDLFTALPPGSVREKLEAEIDRIRKSKSKGLMDASADAGVDEGEDDILGSTDTRIKFSFRGLEDEIGLTVDIVGGAVKSDEEGNLGAGVRKWEEWIGQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R470</accession>
    <name>A0A8G1R470_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_468582</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515866.1">
        <property type="nucleotide sequence ID" value="XM_025662275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R470"/>
    <dbReference type="GeneID" id="37165677"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH57944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="293" mass="32188" checksum="974CFF6A6386CD7E" modified="2022-01-19" version="1">MAEQQLTWLVTGCSSGLGEALVRAILDKGDKAIATARGSKGVSGTDRLSSLKDAGAAVYELDMASPEEEIKKQAQDIWDKYGPIDVLVNNAGYIDISTFEEMTYRDDFLLNSIRINALGPFTLTRALLPRMRARKSGTILFSGSVGIYYAAPCAGPYVGPKGMIESMVPVLATEVAPFNIRVSILTYGHFRTQVMAAGVIQYRNPNRLPEYEEINQRAHDGCLEWSGNQPGDPRKGAELVVEAVKGEGRCKGMELPLRLPLGSDTFGIVRNTCQELMRVWDEWDGVTSRTDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4Q0</accession>
    <name>A0A8G1R4Q0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_257205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH60041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517963.1">
        <property type="nucleotide sequence ID" value="XM_025654995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4Q0"/>
    <dbReference type="GeneID" id="37158397"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="125" mass="14058" checksum="BC29890577D58C83" modified="2022-01-19" version="1">MANQTSMAPEQASDEARHGKGRLGLHELHQFLRHLATFGWFWRRKSQVQRLCDQRPPTTNQRSSAANGRSDAALRWTSQSLDTGSEALYPCQLGNIVLLSGFAISRSPPSAVRTQGAFRSYFMHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R528</accession>
    <name>A0A8G1R528_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chondroitin AC/alginate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_513117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516738.1">
        <property type="nucleotide sequence ID" value="XM_025664686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R528"/>
    <dbReference type="GeneID" id="37168088"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034411630" evidence="1">
        <location>
            <begin position="19"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="403" mass="45108" checksum="76F5328A6D02E159" modified="2022-01-19" version="1">MHILKLCLAVATATHVHGLVQDVPSLNGPVMMVPDTPGSKNRTNQFQHPGLWHSHDQLELMRTNVLNGVEPWASAYTRFAQDPYSNASYEMQGPYPVISRGQISNYTSFHDDSRAAYQNAIMWYITRNQSHWNRSTTILDAWGSDLENIIGTDRSLLIGIEGSIFANAAEIMRWEGGWVEQGATYKGGSGFSVQLYWLFARQSIIIGQANYGMASIMGLLNFAVYLDDVALYNYALYTYKYDRCAGVPYNYLASTGQNSEAGRDQSHVQDALQWTALAARVVANQDYDLFALEDNLIFTAAEYAGKYLMNQTVPYDASFYRCEVVLVDGPWANISAVNRYIGYQDGKTNPAAWGLLYYEALERGVNVPWTSRVKDVYDASVKSQASPVDPFSWADLLFAVAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R673</accession>
    <name>A0A8G1R673_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_223238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518220.1">
        <property type="nucleotide sequence ID" value="XM_025654727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R673"/>
    <dbReference type="GeneID" id="37158129"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="98" mass="10985" checksum="76156233E0C80628" modified="2022-01-19" version="1">MVLGLSSRRWAMTSVGDRLVVLADPFLPLQKPCPEIIDQSFQLHLGACRSRGRWGKKGREKGREALRLADSVFELFLNILTTFFLFASAVSNLVVFMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6U2</accession>
    <name>A0A8G1R6U2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_416288</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518565.1">
        <property type="nucleotide sequence ID" value="XM_025657725.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37161127"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="17"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="13">
        <location>
            <begin position="955"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="2481"/>
            <end position="2558"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="955"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1104"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2557"/>
            <end position="2578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2564"/>
            <end position="2573"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="987"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH60643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2988" mass="327740" checksum="EE20E3E10208DED8" modified="2022-01-19" version="1">MPLMLSEDSCCPSDSRSVPLAIVGFAFEFPQEATSSESFWEMIRHGRSASTDFPTDRMNIEAFYHPSKDRPSNLPVRGGNFIREDLGAFDAPFFSITPGEAACMDPQHRRMLEATYHALEDAGIPIEKCSGTNTAVYTGCFTNDYQSVLQEDFELEATHAAMGIAFSMLAHRVSWFFNFKGVSMNLDSACSSSLVALHLAAQDLAAGNSSMALVGGANIVFHPNFMKMMSSFNFLSPDSRSWSFDQQANGYARGEGIGMLVVKRLSDALRDGDCIRAVIRNTGSNQDGRTPGITQPDGSSQLDLIKRTYDQVGLDMGPTRFFEAHGTGTPVGDPIEANAIGQAFSHCRSVEDPLYIGAVKANIGHLEGASGLAGLIKTILVLEHGIIPPIAGFRTLNPRIDANQLRLKFPKEAIPWPTTGLRRACVNSFGFGGTNSTVILDDAYYYLEQHGLKGNHQTQPCYIAPSPTLQVLAAPSASETTVKVLVWSAADQTAAEKLSAAYHDTIRQCPPEELSDLAYTMISRRSRFPWRGFTVTGGQQLEAVKPVRAGDGVQLAFVFTGQGAQYLGMGKGLISVHPVFQQTVDLLDADLHALGCSWSLRSLFEGDSHLPINQPEYSQPATTCLQIALVDLLQSWGVQPAIVVGHSSGEIAAAYAAGALSRAAAVKIAYHRGRLSSQLASQRTDLSMMAVGASVSDIQPYLARLDQPTAVIVGCVNSPTSITLTGSIAQLHTLQQWLEHDSIFARMLRVPMAYHSPAMNAIAAEYREAMGDLLLPDLKANPRYTTTTTPMISSVTQALVTPEVLASADYWVRNLTSPVEFCGALSRLLFAESSSTSFPITHLLEIGPHRALQGPITDTIRASAASKTATKATPPRYLSLLDRKVPASTILLQATGHLFCAGLTPNLLLANNLPQPKLRPIPSHRLPSYPFNHSQTYWKESRLGKNFRFRTHRRHDLLGTRSLDWNPQIAQWRNIIRLREVPWLRDHTLDGQILCPGTGMLLMAVEAFRQLSLTTTPGIEIRDARFLHALRVPAETEQVETQLTLINEGTEWMRFRLFAMEGGSYVECCEGRIRGAAADHEDELETLVLPSTVTNGKSVQEWVQQVRNGCSQPSSQDIYDGSTGSSLHYGPAFQSIKQLRLGPGARAVAAIDLESWKRVMSEEDAPPYAVHPCTMDGLAQLVVPALNHEQRDTLPTMVPARASRIWMDLRKPALLHQGEILAVAQCRLRGHRGARFDVVGMSVDGDRPLLCMEGLETSFIEAAKPTAVIGDSSLQRQLCTSLVWRPDVDMLDREQLREEVCRDRPSEAPNALGRFRSLQVATLGYVIEAMEYLAQHPEVSVPNYLQRYVAWMHYQRQRLQGSPEWTAAQKLAQDPDAQARLVQEVEDGCGTEGQFFMTVGRHLIAVLSGTEDPLELLFRDGMLHRYYDQMLADAYHAYPASRYLELLGFKNPELRVLEVGAGTGGQTLRSLQTLCPPDAPAQCSLYDYTDISPGFFPAAQQKLADYSPVVRFRTCDISVDPVTQGFEDGSYDLVLASHVLHATDRLDESLQHVRRLLKPGGKLLLFEFTEPNSVHIGFAFGLLKGWWSPLDHEERSAHSPCLSPIRWDERLRQNGFSGVEVEVPGQSIPECQYLSIIVSSADVPDNEQPQPQQQQQIVIRDPSIASQCEMAHELGGQICSLAEASELDIPADAMVVVLLEMEKTLLADVSAHDWTHLHAVLLQAKNVLWITQPPAESPNQIPQHGVVEGFGRALASEDATRKFVTLALDGQVSSARATETVHHLVTEIMRNPVDAVETTYSTTHGVIHIPRVMSNDPMNEIVSQATMPRRTKQWTLEDGSKPAAAATLCIGPPGRLHELEYHEVAEHKGESVAEDEVIFDVQAFGLSPRDALMAAGQLDAVALGSACAGIVRAAGSCTGFLPGDRVCAVGNAMAASLIRTSARAVVPIPANWSFAQAAAVPIPAWLAFYALDCVARLATDETVLVHHSVGNSVQRMAIQLAVRRSARVLATVPSESQKTNLCTALGLAETEVLVVTKDAELAPALMKLAIRGMDVIVGSVTDERMSQHLTSGGRLVDISWGEQQQQQSPLQPFAQRANTSYTRINMAELLQQRPQRAYNIFQEAMAEYPGDQPPQSHVYTAGSETEALQQADLMGGTVVTLDAGRSIPVSCITRPKSQFSADASYVIAGGLGGLGRSLARWMASRGARHLVLLSRSGARTAAAQGLVKELERQGVHVATPAVDISQRESLEQALLELKRTMPPIRGCIQATVALRDNMWENMTHEDWSLSIGSKVTGSWNLHWCLPRELDFFVLLSSLSGLFGAPGQSNYAAGNAFKDSLAHYRIAQGLKAVSIDLGLMLSEGMVAESDFLRSMLHRNAMLMDIAIEEMVALFDYYCDPTLPRLTHSTAQIVVGIEMPSVALAKGLDLDHSVYRPMFRHLFQMDAQRHPRHGEAEMEMAPIAMTTAIDRPALLKQSASIIEATGLVLEWLSGKLSQVLGIAAADVEPSKPIHMYGLDSMVSVDLRNWFNREIGATFTVFDLMSNTPLRELSRMAAERSRYRQKSSNTTTTSSSPAVTRSDEITELVRKYTADLPVRSSRVSMGDATVSDRSTILLTGSTGSLGNYLLHGLLRNPQVNKVYCLNRSDDAAARQRRSFLERGLDTSLLEDSNRVQFLRASFGERQLGLAESEYNHLLVSVDTIIHNAWKVNWNHHVSSFEDPHIKGVRELINFSMASRYNAHVAFISSVNTITAWKPSGVAEERDTIPEEPMESADVVMPQGYAEAKHVGERICIEASRKCGVPTSILRVGQIAGPNSRLGMWNLYEWIPILIKSSKSMGQIPSDLGHYLVDWVAVDILATIVLEILQSRRAATAAAMATTPTSSVFHLTSPTGVSWKSLIPAIQERYPVKLVSLTEWVEELGRLQELSPEEVADKPAIKLLDFYRLLAGAMEASPRMSLEQARAASQTMASLGPVSLAQMSNWLDQWNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R797</accession>
    <name>A0A8G1R797_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_509464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518525.1">
        <property type="nucleotide sequence ID" value="XM_025664497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R797"/>
    <dbReference type="GeneID" id="37167899"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="166"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="337" mass="37206" checksum="D0448CCBF249E969" modified="2022-01-19" version="1">MEVENPTAVTTMSWGHRAPRNIGSRGRTPPSRKGRAQRAKDVARGSQAIDPYLDGVDGVSQRNRDSQTNEDEGSTASVFERYKRRSASSSTSSSDNSGTITSEDSQSHADPHRGAASVSGTTESKQQQQQPPNTIRIKDDRFDRVLLIKPRQEALNYAREVTETSPDDNHVFWVDGSTAANEAAPSGVAVIHGHSGKDADELYCLEEIRLSQLAELFAIGAGLRAAVRRLERLQVSGHVVQVFTDCQAAMEMLRPRTKKLSPLAGRLVRLVDALSHRLCSMRVKVELHWVPGHQCVRGHKRADLLSRTITSFMMNNLADKINQINAVRVDCTFLELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7E1</accession>
    <name>A0A8G1R7E1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_485705</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518494.1">
        <property type="nucleotide sequence ID" value="XM_025663340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7E1"/>
    <dbReference type="GeneID" id="37166742"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="312"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH60572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="342" mass="39165" checksum="E24A944A7FF0A974" modified="2022-01-19" version="1">MDVLQSLPLPSIDRPFGIHLWPIFDKAFELVVGYPASEFRFEEGVTPMSTFKETAVALVAYYVIIFGGREFMKNRPAFKLNTLFMIHNLYLTLISGTLLALFIEQLLPTVWRHGIFYAICDHDGGWTRPLIVLYYLNYLTKYLELIDTVFLFLKKKPLTFLHTYHHGATALLCYTQLIGLTAVQWVVIDINLLVHVVMYWYYFQSARGIRIWWKEWITRLQIIQFVIDLGFIYFASYTYFSSTYFPWVPNMGKCAGEEFAAFSGMAVISSYLFLFISFYVATYKKAAKSGRPRRNTGKQAVIDMAKFEVSAPHADAKGNNKSNGAAVSTGRANGPVTRSRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7J7</accession>
    <name>A0A8G1R7J7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inclusion body clearance protein IML2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inclusion body clearance protein iml2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_364515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as a chaperone in inclusion clearing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with lipid droplet proteins.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518891.1">
        <property type="nucleotide sequence ID" value="XM_025655702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7J7"/>
    <dbReference type="GeneID" id="37159104"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH60969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="629" mass="70441" checksum="27A156BA6F6FFA14" modified="2022-01-19" version="1" fragment="single">FIRATLGFEQEIMRQASERLNAAETSAANDQHRAQHNSHAPNTYHSQIYAPGTEFALCQAMAQLMSAVVGVLNESLTESIKGFYKLRKAYITLDAILKMEQKFIMQARNSGDTTSTESLPRGVGQGAGPTSVPALPVEPGDLKKGFSDLSISADSETSASGPSDMLSHDPDSDIFKNQIDVFVHSGANFCFGILLLLISMVPPAFSKLLGIIGFHGDKERGLRMLWQASKFHNLIGALAAFSILGYSNGFVRYCDIMPDPVPGDDVQGYPQERLEALLALMRKRFPKSQLWLLEESRMNGANKKLDVALELLCGEDRSPLKQVEALRVFERSLNAMYLHRYELCAESFLECVELNSWSRSLYYYIAGSAHLSLYRNVAGTDATAAAKHAEKAVEYFRKAPPLAGKKKFMARQLPFDVFVSRKIAKWEARAKEWKVPLVDAVGVDPIEEMIFFWNGHSRMTQEQLEESMTKLAWSESEANKTWSREGTEEKAILQLLRAAVFRAMRRHDEAKEIIRTSIFSQDKSQFTGHLKDDWIYPVAHFEMAANLWMERPTYSAIHGGPESSSEKPAAGSTENDIQLERRQVHECKEHLEKAAKWESYELDARVGLKVTAALEAVEKWESAHATTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7R8</accession>
    <name>A0A8G1R7R8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_217695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517979.1">
        <property type="nucleotide sequence ID" value="XM_025654659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7R8"/>
    <dbReference type="GeneID" id="37158061"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="118" mass="13330" checksum="CF11265EDCB2B2E5" modified="2022-01-19" version="1">MGQRHNRRRTRPRSRNRSVNPLHLPSHPFSRPVNTCAPAVPSAFDCPEIPAPTWHYGHLLGQKRDRALRMEASTLEAEQYRLFGGVPGDDVGLCYRMLEYFGGLDYIDCPQSLNALPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7T7</accession>
    <name>A0A8G1R7T7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_435235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518825.1">
        <property type="nucleotide sequence ID" value="XM_025658508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7T7"/>
    <dbReference type="GeneID" id="37161910"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="4">
        <location>
            <begin position="55"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH60903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="329" mass="37616" checksum="D03B20D341A0B488" modified="2022-01-19" version="1">MADDASVKIVDEITMKNALNRNFTRLFNSICEANDLSRTSDALIHLPQTANDIWEYVNEAVTVNAHASSQQIQQVHNTSSFAILSKHRQYIDRILKAEIEPVYVEIPQFHSVFFGCVQDSAYLPPTKRPRLSSPNNTSQKPPNCIHRRVILRDHGKPIYTASTHSILLTILEIYITGHQSLHKTGILHQDISPNNLLVNENKNNNNNPSWPAFIIDLDLAIREQRDIPAPEAHGSKKTGTRPFLAIGALMGEKHSFMHDLESLFWMIFWICVHYEAPGRKGRRAVAIFDRWNFVDTGDLAVMKQGFVFNEEDFLRWADGRWKIWDCMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8H0</accession>
    <name>A0A8G1R8H0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nonribosomal peptide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_415260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518086.1">
        <property type="nucleotide sequence ID" value="XM_025657677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8H0"/>
    <dbReference type="GeneID" id="37161079"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF12">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE IVOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="239"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="795"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH60164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="874" mass="95010" checksum="5CE81C6D7D0C5B49" modified="2022-01-19" version="1">MVGKVLTAPCRFPSLSLSPSPQKGRDDDAVHTINITQGDTSISQWGSDLGPRLRVIWAIILSVFVHDDSVVMGYEECANSRDSSYLLQDCSSVYATTFDREDDLTTLVGSGHLLETDSHDPRVYNTGVLLLDGRNGRSDLTAKNGSSPTDTERCDLILGANRGPAGLRLFLRFRTAYISETMAGHIADATQEILYSVRHGWQGKVKDLNLLSQASRDQILSWNTQSLEVSQQCLPDLIDRASSKYPDAIACCTINEQITYRELQHFSTALAAHLLSAGVCPHTYVGLILDKTIWSVVIILAVLRTGAACMPLDSALPPAQASSMLREANTSVILTTTSSSKLEPHWVAMAPQMLEITGHLIQQLPKKPLPAPSGHISPTQPAFLMYTSGSTGAPKGVVQPHQDIVTCVQQMAQALQLHSGTRFLQFAAFSFDLSCVETLCTLSRGGCVCIPGNDDRLHRLAETGTALRINTAFLTAAVLAQVHPDEMPTLKTLTVGGDVLTAEQVALWAPRVDHLNVSYGTTEGIMFDTLHADLTTLSDPRNIGRSFGPRTWIVDPADHNKLLPIGAVGELVVQGGRLSQGYLQKPEKTAAVFIDAAVWAPAPAPTASRCYKTGDLARYLPDGSIYLLGRKDRQVKLRGQRVELDDLEARLKQAVDLPRGMVVADVIILPDQTKQLVGFVYDDRLTKHSAAAAAGALFGLPTAVFQALMRTMVQKLKQSLSWLFIPTFMFPLLYVPKTRTGKIDRTRLRQAAAGLAQQDRLVYAVPLDEGAVGEDDALVKGEYSEQVGLVCKWYAESLGVGLAFVLPKSNFFHLGGDSIKAMRITRLAKDDGYDVTFRDIFNHPQPVRLVANVLVTGSGTDGEMMTMAIATAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8T8</accession>
    <name>A0A8G1R8T8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_445629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520123.1">
        <property type="nucleotide sequence ID" value="XM_025659309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8T8"/>
    <dbReference type="GeneID" id="37162711"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="139" mass="15639" checksum="4D332DFAC330B382" modified="2022-01-19" version="1">MGAKVPRNFRLLEELEKGEKGLGAESCSYGLADGEDMMMSNWNGTILGPPHSVHENRIYSVNIHCGPDYPDNPPTIQFVSRVNLPCVDGRSGKVDPTKLPCLAQWKREYTMETILVELRRYMALPQHKKLPQPPEGSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9A8</accession>
    <name>A0A8G1R9A8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_391696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518147.1">
        <property type="nucleotide sequence ID" value="XM_025656820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9A8"/>
    <dbReference type="GeneID" id="37160222"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH60225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="303" mass="33153" checksum="4B1BE729226FEDF1" modified="2022-01-19" version="1" fragment="single">MTTIRKVTVLGATSTLGSHIASALSAAGHEVTAIQRKDSDKPGPAGLKVIKVDYQNKDELISTFTGQDVVISAVPSPQLTSEKIIIDACLAASVKRFIPSEYTTMMESPQTINLPITKEKVLIRQYLNSVIQDTSSPTAWTSLNTGAFFDMALKYGVLGPNPITKKAVFHDGGDKKIAVSLLSDIATAIVKLLEPTHFEAAANQPVYVCSAVVTERGLTKIVSEVLGVDFGMPEGVEVKKIIEESEERLKRGDMSAVIDYYYLMMYGEGYWGGEFMRWNWNERLGLRIMDEGEVRGAVREVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9N6</accession>
    <name>A0A8G1R9N6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Homeobox transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_517945</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Interacts with MCM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518327.1">
        <property type="nucleotide sequence ID" value="XM_025664945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9N6"/>
    <dbReference type="GeneID" id="37168347"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000286">
        <property type="entry name" value="Homeobox transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="51"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="53"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="103"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="332"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="409"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="485"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH60405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="576" mass="63190" checksum="F3556119A8BFE191" modified="2022-01-19" version="1">MSDPEPSAAPCSSSPPSTQASDSAAALNYAFLVHSQKTLTQNLPPRVDNKLLARQKRRRTSPEDHAILEAEYQRNPKPDKTARASIVSRVSLGEKEVQIWFQNRRQNDRRKSKPLQPHELLAPRSDVSDASKRVSDDNLPTEPGSSSGTEQSEDNCQDRNVASQSSEHVSFGSDVVHGDNNELEQSGLSSQTSLTTEAVEDSQRAPDETMPEQQPALVHDETHVDDSNLASTKRKRSFSETRGNRPFVQGTSTPMKSPPSLRISLSFDGEAMVRKEDELTPSPPKGRNALRIAMSSDGKAVIRADGEPSPSKNRISMFSARKPRIAGLRRSNSAAAFSTPRGGSMETEKLFGRSRDPRNWESFFDTDARSALSTPTSSQSAPNAGSPALFRARGQRSLTRSMSARHSNALNASEYLNTPVPKPTGDKRRKISRTVSSLGRLETGRATLGDKLSNSKTMSTKDDDLELQWGDSDKENWIPGTRTSHVRRRTASHHHSRRSILREANSRDGKANRDLASGGRYSRLSQHQRVSGVIDKDVPEMDAEVSAFMNGGGGASQEEDLDCIQGLLSLSQGAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA68</accession>
    <name>A0A8G1RA68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_362252</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520380.1">
        <property type="nucleotide sequence ID" value="XM_025655619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA68"/>
    <dbReference type="GeneID" id="37159021"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="48"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH62458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="374" mass="40310" checksum="1A63C4D02902EB66" modified="2022-01-19" version="1">MAAPRLFRPAARLLSSRLTSAPLRPQTACAPSILRFRGYATESGTKEVTVRDALNEALAEELESNKKTFILGEEVAQYNGAYKVTRGLLDRFGPKRVIDTPITEAGFCGLAVGAALAGLHPICEFMTFNFAMQAIDQIINSAAKTHYMSGGIQPCNITFRGPNGFAAGVAAQHSQDYSAWYGSIPGLKVVAPWSSEDAKGLLKAAIRDPNPVVVLENELLYGQAFPMSEAAQKDDFVLPIGKAKIERPGKDLTIVTLSRCVGQSLNAAAELKQKYGVDAEVINLRSVKPLDVETIVQSLKKTGRIMCVESGFPMFGVSSEILALSMEYGFDYLTAPAVRVTGAEVPTPYAVGLENMSFPQEDTIVSQAAKLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAY9</accession>
    <name>A0A8G1RAY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Longevity-assurance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_118418</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519753.1">
        <property type="nucleotide sequence ID" value="XM_025653890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAY9"/>
    <dbReference type="GeneID" id="37157292"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="129"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="369"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH61831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="442" mass="50432" checksum="49E6D73053CD4B26" modified="2022-01-19" version="1">MARDASLPASQSASELNARISTSSGHHRPAAKETTFREWMLANQIGISLTILSMLLAVHHLYPSLNPYTTPFFQLSYYQPATGDYVQGWDDIYFIASSAIAFIAIRAIVIDWMLQPLAQRCGLKRKASVRLAEQGWLCLYYGFFWSLGMYIWSNSYYWGDFSAIWDQWPARNVSGLMKWYLLVQLAFWVQMLLVINIEERRKDHYQMLTHHIITITLFGSAYIYGFYNVSNVVLSLMDIVDLLLPAAKILKYLKYETTCNVAFGVFMVTWLITRHIYYPQLCWSIYKDVPARMAYGCYSGTTSEMTSTDAYPNRWRYLLYPFQDISGPICMNRTVKWIFLSCLLALQALSLIWFTMVIRVAVGVLRTGNAEEPRSDDEEEEEDVSGKDGPNGTAVPTDGSSADWRRANGSSNVRPRGRGRVRLGDQSDHKALLGRIGCDKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB27</accession>
    <name>A0A8G1RB27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidyl-tRNA hydrolase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_444672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521308.1">
        <property type="nucleotide sequence ID" value="XM_025659078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB27"/>
    <dbReference type="GeneID" id="37162480"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000065">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="44"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH63386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="204" mass="22982" checksum="D70A65F8533B76B8" modified="2022-01-19" version="1">MFRPLHLTPYITRPFLISNYLPTLPRFFTLSALSLANKALPPRLKIQDADVTISYLKGTGPGGQKINKTNSAVQIIHKPTGVVVKSQATRSRSQNEKIARQLLADKVEELLNGDRSRAAIKADRARKKKASKMKKSRRKYRELEDGKESQEIEEAEEENDAPESADSKHESKLEGADIQSPHQLSAQQPILQQKHLPDIERGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB65</accession>
    <name>A0A8G1RB65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Yos1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_122220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519888.1">
        <property type="nucleotide sequence ID" value="XM_025653921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB65"/>
    <dbReference type="GeneID" id="37157323"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH61966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="82" mass="9165" checksum="DD0EB1CC089054D9" modified="2022-01-19" version="1">MFFFGLGKLVYVIILLINSLAVLSEDRFLARIGWGRTQNDPAFGATYDTTSVKAKTINLIASVRTVMRSMSTNPHISLLHTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBN2</accession>
    <name>A0A8G1RBN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_484247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520158.1">
        <property type="nucleotide sequence ID" value="XM_025663221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBN2"/>
    <dbReference type="GeneID" id="37166623"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599:SF1">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034872847" description="GPI anchored protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="26704" checksum="6320D7AEC3BC2584" modified="2022-01-19" version="1">MKLFGWISAAFLASTVLSLETTPAPSIDTIPFDSPRNADSGRRAFEVLQLLRKRSDNCPSGYDSCTNLGYSDICCADGSRCTRDAADNVACCPTGASCTGTLSETGNSGGGATSSFRFPQTATATQTTDGTSVTLTGSTIAGAYPFVNIPTSFANARVCTSYYSLCQSEYTGCLSQLGGGYAVTVAAEGGGVTRAGGGASAAISTCSSLSMEACHGLSIGYCGSYSTDVYENRGTMPRRSSSLEDLFFGMFIGLAGMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBS5</accession>
    <name>A0A8G1RBS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-Glycosyltransferase/glycogen phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_366910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518322.1">
        <property type="nucleotide sequence ID" value="XM_025655799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBS5"/>
    <dbReference type="GeneID" id="37159201"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="5">
        <location>
            <begin position="135"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="6">
        <location>
            <begin position="419"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH60400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="799" mass="88600" checksum="2B176F0E6351CC87" modified="2022-01-19" version="1">MSDNKETKLVEDSKHDECFEDPPPAYSSARNSCVSSEISLFTIEPDFAPEFTNDSRDLENYCAAAEDEKFSLNPDLAARTSAFIQAFMRPKAQARLVSVGLDEKEPQHTGQFTQTRENVTPPPLDIVLMVVEESIRPFLAVAKQLSRDSHRVRIAAAASCEYLVRSQGLDFFAITYDHELPLSMHNMGDAHPSDEAQARLQYLRRVQQSYYEVYHRCWRACIAPFKGDRRPFLADAIIANPMARAHIHCAERLSIPLHIMSAFPQTPTKAFAHPHARISPYDGVDQSTSNVLSYAIVEESTWNVLTCSSLLSDSILKPINKFRQQILGLMSISPVTAGRLVTDHELPHTYFCSKVLVPRPNDWSSNHGRPYCCYRPLSGNSMKDIYRLALIIQDAILKKGYRVLLSRDSRRLGELLNSTNVLVIESVPLEWLLPRVAVVIHNGSPSSTQLALQYGKPSVIIATTENHLSTAHTIAKIGAGASPLTSRTLTSESLAQAITFGLRTDVQQSTQAIKRQVEEEAGLENAIQSFYRSLPSQVQTCGITKHDLAMYQIWNRPSLVISSEAAAVLVQESRIKITDIVLINRCIYKVQAESSASYDGTAKEYWNGFTNAAKDIVTASDLVSMISGRQKESSTDEERKVKRSVARDVGVGTAKFFGHIALLPFTMNTVTYGVKSVKKHQAQGEKREETDIAATYDIAGDEECDAAASKHPGLSPSREGVDPTKQAWQRGSSRIGITADAEARTGSSATPTANQIQLKNEEHVEAICRRHLDRGFKSPKVADTAFRERILSAFENGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBW4</accession>
    <name>A0A8G1RBW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_445777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520278.1">
        <property type="nucleotide sequence ID" value="XM_025659351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBW4"/>
    <dbReference type="GeneID" id="37162753"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="130" mass="14020" checksum="C122201AC4916AC2" modified="2022-01-19" version="1">MGLRVRYSCLPGASDLALRLKPRPQDLGWPIHGRNGCLLDRACIIPPKAPTARPDLFWPVIVTASSVWMGPSDLSVYIPMACTPSTQEVAIAAPGLPSSQGLLRSSVFRGNQPTGTKDNYLCTLCVVYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCC0</accession>
    <name>A0A8G1RCC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_515623</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520984.1">
        <property type="nucleotide sequence ID" value="XM_025664794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCC0"/>
    <dbReference type="GeneID" id="37168196"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF124">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="17"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH63062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="339" mass="37840" checksum="20FE88C3C2332E38" modified="2022-01-19" version="1">MAVISAGLIISTSCLALRVYTKAQLLHKFGWDDVSIILAWVFSLGTQACSIYGYKHGGMGIHFWNVTPVVYDVYVKVVLSAAIIYVPALALAKISLIILYYRILCQKRYQQWILYGIAFVVSSYSFALVLAFIFGCHPIQKGWDISVTGTCVNQYALYVATAVLNIISDIALILVPIPTVVGLNMPGIQKLGLLLMFMVGCATLVTGIIRLITLIPFLNSSDPTYNIGRPDLWINIEANFAIICSCLPFLRHFLRRYAPRLIGENSSLARRYHSYTYDYTGGSRARRKEGLTQLQDDIELAENGGSMHSGVRIFKDVQVEITTETMPDVNRNREGDGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCH5</accession>
    <name>A0A8G1RCH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_238963</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518682.1">
        <property type="nucleotide sequence ID" value="XM_025654817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCH5"/>
    <dbReference type="GeneID" id="37158219"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289:SF33">
        <property type="entry name" value="SERINE_THREONINE KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="94"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH60760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="412" mass="44558" checksum="300E0A6011A34A2F" modified="2022-01-19" version="1">MTPTHLPFPLSVRTQHDTDTCAPPLLVVPGLTPPVTPTVDDESLSGSVATLHSGASSPFLSPVEGKFRDVDAEDRTVSTSDSFTDELEYHKDPKGRPVEYGRGLWSVVYKATPCEPSKPYLLTPPSSPAVKARTVAVKSPARRDAHSILDAEALALTRVSRVAGSQNHVVPFKGYIADSHSIVMSAVPLALSTYIEEKAAVALQNKTTKTMFEPIQGMTQWYDLAKKLITGLCWLHDGPQMVHGDIKPHNILLRARSNDDDLESDHFPYEPLFADFSSAHPISNSSSPESSLGTALTALTPPFTAPELLCVSSLKSPDVAPTPESDVFSLAVTLLAAATGDLLLYPGANHFQRLAMAREGHRVIEFARSGPNGSRIPRNGIVEQIVKPAILKDPSQRIKPAEWVNLVESITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCK7</accession>
    <name>A0A8G1RCK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PQ loop repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_3060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520499.1">
        <property type="nucleotide sequence ID" value="XM_025655374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCK7"/>
    <dbReference type="GeneID" id="37158776"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:organic cation transmembrane transporter activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
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        <property type="entry name" value="PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER YPQ1-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH62577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="386" mass="42471" checksum="748A87A0735B34E2" modified="2022-01-19" version="1">MFPAVTGNIDLEALSGICGSISIACWVVVFSPQIIENFRRGSADGLSLLFLIVWLAGDVFNILGAVLQGVLPTMIILAVYYTLADVVLLAQCFYYRGFTLRDEPSTPPRPASPITTDAYDEDTEIPSPVVPRKPTEHTALLSSKRRSASYQAPLDARSPASSATITPHHQPLLAHRRHSASSFLHTTVDGTHLSPATPLVEPAKQPRPPRTLTMLQATFFNGSAIILVCAAGILGWYISQQSSLSSDNNNNNNKRKDSTDDLKMDTLGQVFGYLCAVLYLGSRLPQILLNYRRKSTDGVSLLFFLFACIGNLTYVLSILAYSPVCQRRHHGRCRSDELASLYGRYILVNLSWLIGSFGTLLLDMCIFIQFFLYQDGNGSEVDAEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCP6</accession>
    <name>A0A8G1RCP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">MICOS complex subunit MIC12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Altered inheritance of mitochondria protein 5, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Found in mitochondrial proteome protein 51</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_446005</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MICOS complex subunit Mic12 family.</text>
    </comment>
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        <property type="protein sequence ID" value="RAH60850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025659398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCP6"/>
    <dbReference type="GeneID" id="37162800"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031463">
        <property type="entry name" value="Mic12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17050">
        <property type="entry name" value="AIM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH60850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="123" mass="14398" checksum="75BDC7BFF6745CEC" modified="2022-01-19" version="1">MGFFAGFFSGFALTTSVLYISLQVHKANRLEQRNAIREQTRALNWLASSAGAYDRRLLPQETQKRPGEEEDRKTKPVLKDFLKHRWNQEVETLARKAYESRWEDARDTAVEGWKTVVRLVKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD55</accession>
    <name>A0A8G1RD55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal protein L24E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_361398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520799.1">
        <property type="nucleotide sequence ID" value="XM_025655589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD55"/>
    <dbReference type="GeneID" id="37158991"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058345">
        <property type="entry name" value="DUF8032"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949:SF0">
        <property type="entry name" value="RE27538P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949">
        <property type="entry name" value="WHITE COLLAR 2 PROTEIN WC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26087">
        <property type="entry name" value="DUF8032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="DUF8032" evidence="2">
        <location>
            <begin position="289"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="773" mass="84391" checksum="CAB150998D6B7B32" modified="2022-01-19" version="1">MTGMVQTDLAHPPAPKYKDEPVEDPHRHPGPQPPHLHHPRPTLLVQPQKQPESPHQPSTTLPSGSYAHHALGNGVIHHQHSYGPPSEHSYYSSHSSYSTASAPSQYSSSGPPAMMATATQMQRPYPPIYHTPQSSSPASVASQTQEQHNRGIYTQSPQMTSQMYGYPPYSPMNPVQPPPYGPNTSPQQHPLTTQPLMVPHPTSTAQLPHHPAQAPTGNLSSSPNSAAAQQPTPPQRTMLNPPHSAASGAPLSASAVHHQNSNVGASSSAAPGPIPATTPLVVRQDSNGVQWIAFEYSRDRVKMEYTIRCDVESVNVDNLSQEFKTENCVYPRACCSKDQYRGNRLVYETECNAVGWALAELNPALRGKRGLIQRAVDSWRNSNQDPRLRSRRVRRMAKINKRQGMPVPPPHMAPSTPVGPGLPSASMPAPGPRPSLGPLPMGPPQLHHHHAQPDGSAGHEEASGTTDYTNGTSRPPVSDGLQPGPSPTDIRTAQVFHGYPSYPTPATAAGGPRGPSIPPLLRDSGLGSLGRHPTIATSSNRIEEVDDDDDERNPSSDALFGTLPEGKRRKFILVDDNQRGCRVRVKVMLDQVDMDELPDSYRMSNAVYPRTYFPVQMRDPGRVVPGNRYIKDHVGVDEEDADDDDSPTVGRIMVPAPQIDGEGEIAVPRLSRGRRRREVLLNDLGYRMSWSQSRVFAGRMLFLQRSLDAYRNKMRSTMLAAGQEPTSIPRHFETRAGKRRFLERKRRAAGGPTRGAGAHGVSASQRSAEEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDA8</accession>
    <name>A0A8G1RDA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_445752</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520262.1">
        <property type="nucleotide sequence ID" value="XM_025659345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDA8"/>
    <dbReference type="GeneID" id="37162747"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 11 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH62340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="232" mass="24911" checksum="E388D326F6D1C572" modified="2022-01-19" version="1">MVGHGMTGMLGEDGIHVDMNHLKSGEVNLGTSIMAINFKDGVILGADSRTTTGAYIANRVTDKLTQVHDTIWCCRSGSAADTQAVADIVSYHLNMYAITNNEAPSTQVAASLFQELCYENKDMLSAGIIIAGYDPKHGGQVYSIPLGGSLHKQPYSIGGSGSTYIYGYCDTHWRENMTEEEGINFVRGALQEAIKWDGSSGGVIRLVVLTSRGAQRHLYLPDTGYTGPGVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDH2</accession>
    <name>A0A8G1RDH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell wall protein DAN4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_494936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521118.1">
        <property type="nucleotide sequence ID" value="XM_025663889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDH2"/>
    <dbReference type="GeneID" id="37167291"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034392244" description="Cell wall protein DAN4" evidence="3">
        <location>
            <begin position="19"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH63196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="29292" checksum="7CC804FF27A5DE70" modified="2022-01-19" version="1">MQLRYLLALSALSSAALAHAEPAAGVFSLSPQTEAPVAQPTSIVDQYLKPKRYNRSLNFQKRATTTDDTTTTTDAATTTADSTTSTSSSTTEATTTSDTSTTSATTTATTATSTSSSSSSTTSSSSSQSTTSATSTTQSTTTTSTTTGTTTSATSTVSAAQKEYNHRGEIAAIVTFSILIFIFLALTFFLCFREKAKTNRLAKKADAGADYSMVPLADGRPQSEAKFDRASMMFASNSQLNLDQMARRPTSMAASETLSVPMNRTAPGTPSDEHRANMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RE17</accession>
    <name>A0A8G1RE17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_454809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520637.1">
        <property type="nucleotide sequence ID" value="XM_025661344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RE17"/>
    <dbReference type="GeneID" id="37164746"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="192" mass="21566" checksum="BAEA90356FD84033" modified="2022-01-19" version="1">MAEDNNKQNPDTSDEGLYDFMVPLCPGPYVTIQVGDKGAKYKWLYLNRIEFPSQIQGRCINAYIELARLADMWAITGMEQLLADKIKAVITSSIPRVNLSCVGGENGKIRHLTSSHIKSASMLFKGHPVRALIAEASAGPFILMDNFKFARELRENANYAGDLLDELKDLIKGQVKDKRVITPYTLHYWKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1REH4</accession>
    <name>A0A8G1REH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1446 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_495600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521519.1">
        <property type="nucleotide sequence ID" value="XM_025663941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1REH4"/>
    <dbReference type="GeneID" id="37167343"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF2">
        <property type="entry name" value="DUF1446 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11420)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="2">
        <location>
            <begin position="494"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="603" mass="66306" checksum="EC68A5A9F99749B2" modified="2022-01-19" version="1">MTRGPTNRPVRIAGCAGGNTDRWDAIKSFASDPSIDAIIGDWLSESNMVGTAAIKARDLTEENEQNRSKGAYAKEFLQCFEPAIADLSAHGMKLVVNAGASDTELLAIECQKLVQQSGHGHLRIAWIEGDDVTDVLLEQRKKGDEGYPIRLSGKSLVEVDPNFVFAQCYLGGWGIAKALAEGADIVICGRVSDASPVVGVAAWWHGWPENNYDELARALIAGHLIECSGYATGGNFTGFKSLLKAGKHLKLGFPIAEIEANGEFTIAKEKNTGGCVTVESLTSQLIYEIQGQWYLNSDVVADLTGVNLEQIAPEQVRVTGIVGMPPPPTTKLGFTTFGGYQAEFHAFMTGLDVDEKCKWTEEQIREAIGEDIHRFTQLRFHRIGSPSLDTTCQDHATVMFRVFAQTKDPEILRTDALTPSNDPRQVHAKPYYNYNTGLIPQSVLNQRVHLLATDPKKIITIDPPSVTQTYGTQPSHETENPVDISAFGETVKAPLGSVVYGRAGDKGANCNVGFYVKHQDEWDWLRTFLTTDKIKGLLGPIEYSGNQIDRFEIPGVRVVHFLLHDHLDRGYNSSSSCDVLGKNTCEFLRSKTVDVPKVFLQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RES8</accession>
    <name>A0A8G1RES8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Metallopeptidase MepB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_387068</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521012.1">
        <property type="nucleotide sequence ID" value="XM_025656652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RES8"/>
    <dbReference type="GeneID" id="37160054"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.40:FF:000001">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000006">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="10">
        <location>
            <begin position="221"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH63090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="716" mass="81761" checksum="23497E772C0C4168" modified="2022-01-19" version="1">MAPEHLRRPPQAPPVFTATAQSIVDDAKRLIEASRKVQDDVVATVKPDTATFNAVVKPLAQDENVMSLESHILGFYQAVSTQQELRDASSKAEELMDEFFIEAAMREDVFQLVDAVLKLNESLDPESRRLLEKEHKDFIRNGLGLPAGPKRDRFKEIKKRLSQISIEFQKSLNEENEGLWFTREELDGVPEDVLAGLKKGEGEHEGKLWLTFKYPDLFPTMKYAKNPETRKQVMIQNENKCNQNVPLFREAIILRDEAARLLGYPNHAAFRIEDKMAKTPETVNTFLGDLRSRLTAGGQKEIKNLLEFKKSDLESRGEKFDGHYYLWDHRFYDRLMLEKDYSLDQQLIAEYFPLQTTIEGMLKIFEELFGLVFVEITGEDREKVAPTGKGSDIVWHEDVQIFSVWNDEGEGSGFVGYLYLDLFPRTGKYGHAANFNLQPGFIDAEGNRRYPATALVCNFTKPTPKKPSLLKHDEVVTLFHELGHGIHDLVAKTIYSRFHGTNTVRDFVEAPSQMLENWCWTPSQLKSLSKHYSTLSPDYLAAWKEQAGSQEAPSEQIPDSVIENLIRTKHVNDALFNLRQLHFGIFDMTVHQPESHEKIKELPISATYNSLRKQITQMEGPESLGLGEEWGHGEATFGHLIGGYDAGYYGYLSSQVYSTDMFYTVFKDDPMNPTAGRRYRYKVLEKGGSQDEMTTLTEFLGREPKTDAFYKDMGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RGW9</accession>
    <name>A0A8G1RGW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenol 2-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_494759</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521022.1">
        <property type="nucleotide sequence ID" value="XM_025663873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RGW9"/>
    <dbReference type="GeneID" id="37167275"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF7">
        <property type="entry name" value="P-HYDROXYBENZOATE-M-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="410"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH63100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="622" mass="69486" checksum="AF56798A5FCAD693" modified="2022-01-19" version="1">MAECYDIVIVGAGPVGLMMSACLLRLGPYKIKHIDQRSGPTETGRASGIQGRTLDVLQNLDLKRAIMSYNPGRIYEVAFWDSSKDGPGIRRTGTAKSYPDYIDTRHPFSTIIHQGLIEKVFLDDLRERGAEVERTWTIAGFRKDPCREYSNHPLVVDLVSADGTRRLTVRTKYLFGADGARSRVRDLLGVPMLSKDPTIHVWSVIDGVVKSDFPDIQIKCTVHSPKGSAMIIPHGNNRVRIYAQIYPKDGEEPLAFATVPKIQQVANEILAPYKVEWEKVEWHSAYRIGQGLAAKYSLDERVFIGGDACHTHSPHLLQPKAGQGMNYGFLDAHNLAWKLHLVEAGFLRRSLLKTYEGERKLAAAKLIEFDATYANLFSSHRPISGNSSAPSSEFVQVFKQNSLLTSGYGVEYPANSLTWASTICSTDTTTLRPGRSLPTATVTRVIDAHPVYLEQEIPFNGSYRIYIFAGNPVTTSQAMFDLADHLQAKGSIFHRYQRKDIDTSYEGRHNPHSPFFTFSIVFHAPRSTIEIQERLPYYFACYRHHVYADDRESSRVAEIAESNAHRKMGFDADRGGIVVVRPDGYVGCILELTDGRASASALNDYFEAFVPPTEHGAVAPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGN9</accession>
    <name>A0A8G1VGN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_201702</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510398.1">
        <property type="nucleotide sequence ID" value="XM_025654539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGN9"/>
    <dbReference type="GeneID" id="37157941"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="91"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH52476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="341" mass="38988" checksum="A9C131C8AAF76D58" modified="2022-01-19" version="1">MKGQADTTTAESPPPLWKVRMPFWHRVDCFIRLWLLKSLAAIYFYFRRLVRQPPRRYQPTFVRRYPSRPMLNAHIFFPPNYRAGERLPLYLNIHGGGFAVGNVQVDDRFCAAWTERTGMLVVSLDYRRVPRHPFPTATYDLVAQIKDVLADESLPIDPERITIGGFSAGGNLALSVSQLPPLHGRVKAAVVYYPIVDFGHPPPVKLASRPYTDGPLDKIGMMAWALDWGYVCVGQNRRDPLLSPWYADPKDLPPRIYMIAAQWDMLRLEAQQMIHRLAGLYDKEDQEAPFETSAYKWTLARGCTHGFTHGQEGNAAERAYRKKVCEDIYGQAHEWLKSALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHJ8</accession>
    <name>A0A8G1VHJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_453002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511386.1">
        <property type="nucleotide sequence ID" value="XM_025660967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHJ8"/>
    <dbReference type="GeneID" id="37164369"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034002724" evidence="1">
        <location>
            <begin position="24"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="156" mass="16723" checksum="B2B784EDDBCFBA24" modified="2022-01-19" version="1">MSKTKTLLLSILIILLSLCAVVALIVASIAMKKTRELEDFKSSLFISDLGRIFNSTAYAIAKSGPDAPACSNITAETVTGQTTLPGNCVSVKESYDMWVTRLADNCAPYLFAEENCTGAFREFEKLATPACIVAAGGGRLSGKEGNFYRSFQISCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHM1</accession>
    <name>A0A8G1VHM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate permease Mch4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_462938</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511461.1">
        <property type="nucleotide sequence ID" value="XM_025661880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHM1"/>
    <dbReference type="GeneID" id="37165282"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF305">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="255"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="449" mass="46571" checksum="92AA63D372C3E0EB" modified="2022-01-19" version="1">MTSTSTTTAVEWQQGPPIELESRAPKNAVAPISDPTDEVMEASRLADAEVPEGGAGWIVIAGCAVITWWFIGTSYCWGVLQAALVKEGVSSASTLSFVGSLAPACISFLGILNARVIRKLGTRTSALLGIFLLGLGEILSGFAVHEVGGLFVTSGVVMGLGTSISFMVVSITPAQYFKAKRGIANGIVYAAGGLGGAAISFILDALLSRVGTAWTFRILGFITMGTGLPAAFLVKQRIPIPPSAFVEWRLFRDIRFLLLFAAGAIATFPLLVPPFFLPLYTDSLGLGSAAGAGVVAAFNFSSALGRLTCGFASDTIGGLNTLFVSLLLSALSMLIIWPVSTSIGPLVVFVIINGMANGGFFSTIPTVVGNVFGSARVSVAMGMIVTSWAGGYLLGSPIAGYILDASGGEDAGIQAYRPAILYAGFMALGASILAAFIRLKTDTRLLKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VI53</accession>
    <name>A0A8G1VI53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF500-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_462305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512016.1">
        <property type="nucleotide sequence ID" value="XM_025661840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VI53"/>
    <dbReference type="GeneID" id="37165242"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="102"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH54094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="324" mass="34157" checksum="3BFB5E5F39731231" modified="2022-01-19" version="1">MPPFEKLRKMHSPFPGSFRSECNKAGQILDAFTNPMNPDGRDSLIPPKILGAAKASGITTGFAIFSVSKLGIVGSVRMGSGILIARLEEGDWSAPSAILTAGVGVGSQVGLEVTNFVFVLNTTSAVRTFAQLGSLSLGKTASFAMGPSGRFGEVNGVVSAGGMAGIFVYGHNQGFFGGFSTEGSMIFERRGANQKLYGKKVKARDLIEGQFPPPDEADELMRVLRSDLFAPRPELYATSSASTKGSISSGRPSQSSAGTDIQKMPIEMPADEIVQLPAELPAEFIAELPAEVVPDIYYDKSVGSSETLLPELPSETASLRPAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIE7</accession>
    <name>A0A8G1VIE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">3-oxoacyl-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_381910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511104.1">
        <property type="nucleotide sequence ID" value="XM_025656444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIE7"/>
    <dbReference type="GeneID" id="37159846"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="592"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH53182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="662" mass="71966" checksum="54EEAE5A2EA5B545" modified="2022-01-19" version="1">MLAESETPISNGDPPKLRAACENCRQSKVKCNLSGKDTCIRCMRHGLPCRYRVANRSGKPKGSKNRATLRKLGQLQDEKKPTIPANGWAEPVAKGQPPRISYDDNGVDATSTQSTSPASQSRSPDSHRANLADSTLLTDQTMEYPSIGETLAPMFNPSMSPPFLPKEFISRGFTGCPLAVHIPNPLQPCDCTNTLLYNVNQIRTMLAESLRLRLDQILQGINIALTACRTFLRCPNCHKDHTNLLYSVSILDTTLQLFEYWTSYELSSAPPGDHNMILPYGEYEMGPDETRRIRRYLIRGRALQCREVLGLLKDAVEMSRHLTPELRELNGTDGLEVEWFQQMLGGPSSAQTRNKYKMNRLTQITSHLNYPHGLLANQVAIITGAGQGIGAETARLFANEGAKVIIADIDGEKASAVATSINNALNDIRALAVPGDILNDTYIEELVTKAAEFGGGKIHIIVNNAGFTWDGVIHKMTDTQFTTMLNIHATAPFKLIRAAAKYFRVKDGESRVVINISSTSGVHGNAGQANYAVAKAGITGLTKTIAKEWGPAFGVRANTIAFGFVKTRLTAAKEEGAFITMADGTKVALGIPGKQLDSRRTGTTTSSSDEKKKNKGGSDYPDIPLGRPASPEEAARAVLGVASPLFSYVSGEMIRVTGGRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIK5</accession>
    <name>A0A8G1VIK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_426855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512556.1">
        <property type="nucleotide sequence ID" value="XM_025658138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIK5"/>
    <dbReference type="GeneID" id="37161540"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF814">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH54634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="361" mass="39818" checksum="ACE16BFF552A3D01" modified="2022-01-19" version="1">MVSSTRSQHVLLTGADGFVASHILSILLERGYTVTATVRSQAKADDVINAHPESKGKVDFVIVSDFTSPKPFSTLFEETEALFDYVIHAASPFKFDFKDFHRDLIDPAVKGTTQILESAHQHGGSTLKRIVLLGSGVSVLDSFEDMSREGHPYTEKSWNPVTAQQAIDRNDPVLGYNVSKIQAERKAWDFMQANSPNFDLTVINPLIVTGPIIHPISGKESINESNYFAIASFIDGTHARIEDVQFPYYHFVDVRDVARSHVDALTNPAAGGQRIVLVSGLITPQLVVNTIRKHFPQLREKVPAGPPDKVLPEGIHPTGCDTRISLDILSKGKGSQWKYIGLEESVRDAVQSMIQHNVLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIN1</accession>
    <name>A0A8G1VIN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_492246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511344.1">
        <property type="nucleotide sequence ID" value="XM_025663767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIN1"/>
    <dbReference type="GeneID" id="37167169"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="61155" checksum="9DD6E01C7B97520B" modified="2022-01-19" version="1">MAQDHDSHNMLKRRLLRGEITYAAAKEQDSNILHELGYRDQKIRYFTHLYRNRKLIESIVAHHLNLPSADTCHAVDVEDWIHGSFNVCIRVEVDSQGRDPRKQLMIRFPLPYRIGENSCPGNTDEKVRCEAGTYSWLQENCPTIPIPQLYGLGLSTGQAFTLLDNLPFVTRIVERLRRRLLAWLNYPTPSLYVQHRANVQTMLGTPYLLIEYIDPSRGKMLSETWEEGRHNLKLRTNLFHGLSRIMLGLARIPLPRIGSFLLDEKGYLTLSNRPLTLEIHQLETEHIPVDMPQNITYSTVDAYVNDILAFHESRLRHQPNAVNNIEDGFYQTSALMVMRSVWTCFFRRDLLRGPFFLNLTDLNQSNIFVDDDWNIKCLIDLEWACSQPVEMIHPPYWLTNQAIDLISMEDFEVSHREFLEAFADEEKEFELPVRLYPILQHGWERGTFWCSLALSSPTALFKIFYDFIQPRFSKAHDDPAFWQITMPYWTFDTFKFIEQKVKDKEQYDNSLREAFESGSSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIP3</accession>
    <name>A0A8G1VIP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_471267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512483.1">
        <property type="nucleotide sequence ID" value="XM_025662463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIP3"/>
    <dbReference type="GeneID" id="37165865"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="719"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="921" mass="101347" checksum="63B134650F896AA2" modified="2022-01-19" version="1">MEDIRPTAKWANRMLRPLKSIHHRLQKHYEIRNSIADTKSKVKPDPHDSHRSRAPLNNKRAGNEPGCNLSDEEPDDPAWIPGNRGNRRPRHNYSNRGQRNGARRRSRLLIKSPEVQRTLPGAIEIATPLITGTIPGPTEATLSIRKRLFRNSGPPLSAVGANRQSRTNNPSFPAYQGSWKEVLDLSGDPGLVDIARFLDRMLIKFLENTRPAPTIHKHDEENRGARSLLSMAARRLPGFIAEEQRLQDQVEPDEDVDMCDAYFTELEAQYAPGGGGWQPLREAMMMREWIPSLAHGELDAFETLMSQYLTTIKTHDYPTAFDPSKPVGHCDNPIYILRSYYSKAPERRSFVFDEMTKLLSRRALPPEWMVTTRWKKCVDGAIRSLSIGDGDSAAATRTIEAIILSSAGIYPATDSLVARNKGRKVPRSVRLKDTRASVTNPTRVPKDQSPCPVPIQDALSNLSASLVTALCGMYMARTQASGANDKITGTKVRHIVGTLSFGVQRAVGLVLSRREMEGPSFQSLRRGYVLLGEWTLQCTESSTPEVISQSGAISPENLESLCISLIHQQDAVKQLAEFVQQLFRCCGHAREDDPARTPRKIRAIVWRLARLTSMKGISLLLAKVAAETAMALAEVTLDVDDHAWALEIQEQAASSQQEGNLHKSAALAHVPQNDVIHLYRWEESIGEWVSSTPVAKPLASRNADGASSPLAATAKRRPSALSCSTSSRSSSPELSEEAASSVTSSAPSMSGKRGRGTNDWRPPSPKRLRSSSRRITAAPVASGALPATRERLAAARSLEPDSAPIATRARTALRDLPQAKNSTLKKTKPQPGPTTPSISRADPIKVTPLIEVVIVNQPVSVRSLNRTPGTARKQPQQPPPQIPSPPVVQGPRRSTRTRPPPVERVIPCSDDDSEDELSFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIQ6</accession>
    <name>A0A8G1VIQ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FK506 suppressor Sfk1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_482228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825090">
        <property type="protein sequence ID" value="RAH51968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509890.1">
        <property type="nucleotide sequence ID" value="XM_025663092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIQ6"/>
    <dbReference type="GeneID" id="37166494"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH51968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="275" mass="30586" checksum="72C7EACB865BCFCF" modified="2022-01-19" version="1">MWIISFWIFPIISACTWIAMLIAMLATWAREGSPIYASMETGQTIAYISDVGAQGLKPLFIAGSCVTVVFLDLSFLSERWLRHAGQLVPNKGKFDKACAIASICFSIAGALGLILLSIFDTLRHPNMHDGFLIMFLVGYLISAILICCEYWRLGIFYRSQHRVLLASFIIKLSFVIIEIALAIAFGVLGNKGGHYRNAAAVLEWVIALIFTFYVLSFVIDLLPSVRTRKHVPQGEKVSRHGQTTAAYPDGTYDYEEPVTTDSAGPNANYYRGQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIU2</accession>
    <name>A0A8G1VIU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_155688</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511539.1">
        <property type="nucleotide sequence ID" value="XM_025654183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIU2"/>
    <dbReference type="GeneID" id="37157585"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH53617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="413" mass="46434" checksum="288D5763FE0863D2" modified="2022-01-19" version="1">MDWMRLIRDLCLNPRHTKWMAPLLVLGDAFLCALIIWKVPYTEIDWTTYMQQISLYLSGERDYTLIKGSTGPLVYPAGHVYSYTFLYHLTDEGRDIFFGQILFAVLYLITLVVVLCCYKQSGAPPYLLPLLVLSKRLHSVYVLRLFNDGLAALAMWVAILLFMNRKWTAAVAVWSTGVAIKMTLLLLAPAIAVVTVLSLSLGPSVRLGVLAVLIQVLLAIPFLQNNPAGYLSRAFELTRQFMFKWTVNWRFVGEELFLSKKFSLALLAIHIVLLGAFAVTGWLRPSGSSLPVIIQNLLAGRQRTVSLSRPYIMTVMLSSLAVGLLCARSLHYQFFAYLSWATPFLLWRAGFHPILLYLIWAMQEWAWNVFPSTNLSSVVVVLALAAQSFGVLANSASAFDNMRSKLSGKEHIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIV4</accession>
    <name>A0A8G1VIV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_427732</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511957.1">
        <property type="nucleotide sequence ID" value="XM_025658171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIV4"/>
    <dbReference type="GeneID" id="37161573"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="21"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH54035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="145" mass="16150" checksum="58F9C49A1DAC5A26" modified="2022-01-19" version="1">MAPAKEPEKQNSTDPSTDYCYNGSCHCRAVRFSARFPSPLSQLTVISCNCSYCHIAGSLLAFADDMEIQGTELLTEYRFATHTIQIFFCRSCGANVYNKSINPKWQYGRCAINIRLLHGIDLEAIEVTKGDGKNIRLPPLEGNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ46</accession>
    <name>A0A8G1VJ46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">TATA-binding protein-associated factor mot1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Modifier of transcription 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NCT transcriptional regulatory complex subunit mot1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO85DRAFT_91096</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box via its C-terminal ATPase activity. Both transcription activation and repression require its ATPase activity. Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms the NCT transcriptional regulatory complex with nctA and nctB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512963.1">
        <property type="nucleotide sequence ID" value="XM_025665779.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37169181"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000508">
        <property type="entry name" value="Probable helicase mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000445">
        <property type="entry name" value="Related to MOT1-transcriptional accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000428">
        <property type="entry name" value="TATA-binding protein-associated factor 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="1319"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1666"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="184"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="701"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="701"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RAH55041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1895" mass="210549" checksum="792D2B0E0417C2B9" modified="2022-01-19" version="1">MSSRLDRLVTLLETGSTPLIRNTAAQQLADVQKQHPDELFNLLGRILPYLKSKSWDTRTAAAKAIGLIVANADTFDPNEEDGETIKKLDEDDVEIKSEEEQPSSPSDSLLQLETLDLASILKYGKRLLGSAGKEYEYSLAAMDPVSRLQHQKKTLTSRLGLAGEYIEEDLIDDNDLVLKTPAIKDEAPQKETNHHNSAPPLASPMESANGEESGLSKRQLNQLKRKNKQSARMGANKVRVVDLSTRRPSDNVTTPSATTPHPIKAENGEEKNGDSKQDYFSLERSSGDDDQKIVSEFKGSTAPEKPLIQPDTSDEGPSNSWPYDPMCEILTMDIFDPNWEVRHGAAMALREVIRVQGAGAGRLRGKSRPENDVLNRKWLDDLACRLLCVLMLDRFGDYISDNVVAPIRETVGQTLGALLSQLPSRSVVAVYKCLYRIVMQNDLGLERPIWEVCHGGMIGLRYLVAVRKDILIKDRSLMDGVLEAVMKGLGDYDDDVRAVSAATLVPMAEEFVASRQSTLGSLMNIVWDCLSNLQDDLSASTGSVMDLLAKLCTFREVLDAMKANAAVDPESSFGNLVPRLYPFLRHTITSVRSAVLRALMTFLQLEGEGTNEWVNGKALRLIFQNLLVERNEGVLKLSLQVWSELLNSLESRGVFKADGDLLSYIEPLITLTMSPFGVPRYPLPMDASLFIKPSGVPFPNSAAAPAKSSPTANNAAADGPKKRGRKAEKKEAPPPSAHNVDGHMLQGDIDLVGADTMLRSKIYAARALGKLLFLWDKNELPSLWQTILAGLRHTASTSQLSTAMIVEEYARVSGPGSKYASLLTEQLRPIIEGERPLWYSDIACYLQVARAQCHSLLYAFKDHAHVPGSRLPTLAVVVQGEEQAGPSAFSLADAEKVAGPDFERLKKGLAPAQRITALQVLNDTRATAENAIEEARSVREQRDLRVRAAAAGALVALHDIPKKPSHIIKGMMDSIKKEENAELQQRSATAIAFLVEYYTTATKRGPVDKVIGNLVKYCCVDTSETPEFHHNATLEKSILSLRKEEDRRDHPDAAKFEREAKEARIMRRGAKEALEQLAVKFGSQLLEKVPNLATLVERPLKEALAGDLPQEIVNPDNELGQEVVDGLSTLRALLPKFDKGLHPWIIGLMPLIVKALQCRLSVIRYAAAKCFATVCSVITVEGMTMLVEKVLPTINDPLDVHHRQGAVECIYHLIHVMEDGILPYVIFLVVPVLGRMSDSDNDVRLLATTSFATLVKLVPLEAGIPDPPGLSEELLKGRDRERKFMSQMLDVRKVEEFQLPVAIKAELRPYQQEGVNWLAFLNRYNLHGILCDDMGLGKTLQTICIVASDHHLRADEYARTQSAEVRKLPSLIVCPPSLSGHWQQEVKQYAPFLNCVAYVGPPVERAKLQGNLADADIVVTSYDICRNDNDVLRPISWNYCVLDEGHLIKNPKAKVTVAVKRIASNHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKVFLDRFAKPIAASRFSKSSSKEQEAGALAIEALHKQVLPFLLRRLKEEVLNDLPPKIIQNYYCDPSDLQKRLFEDFTKKEQKELANKLGSSEKSDKEHIFQALQYMRRLCNSPALVVKEGHKQYNEVQQYLTTKQSHIRDVSHAPKLSALRDLLLDCGIGVDPPTEGDLGTGASYVSPHRALVFCQMKEMLDIVQSEVLRKLLPSVQYLRLDGGVEATKRQDIVNRFNSDPSYDVLLLTTSVGGLGLNLTGADTVIFVEHDWNPQKDIQAMDRAHRIGQKKVVNVYRLITRGTLEEKILNLQRFKIDVASTVVNQQNAGLNTMDTDQLLDLFNLGETADNAEKPNEQAGNEVDMVDIDGEVKEKGKKGWLDDLGELWDDRQYQEEYNLDSFLATMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ84</accession>
    <name>A0A8G1VJ84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_427466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512362.1">
        <property type="nucleotide sequence ID" value="XM_025658156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ84"/>
    <dbReference type="GeneID" id="37161558"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH54440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="31673" checksum="1101ACC01A782527" modified="2022-01-19" version="1">MSAGVTTSASTTASAPIPLTTTFVPPSTCISDFWLVSSSSKTWMNLGPAHTAECVPSGWDVSSYFSPGLCPTGYRIAASNIVIDGTITETAATCCPTIGIQTYSTRTTYTPGWTELEVCTWEPGKSTEIEFAYTWTDTAGSTSSTSSSLSSPGHINGYGISIRWQSTDFTTPAATSASTTSSGDLPATATSSTISPTSTSSSSSSGLSTGAKAGIGVGVAAGAVLAIFLLLFFLRRRKVNASSANQQAYQSTDKGYRVQRVNELPATRTGAFMTEQVELPASGRDAKAELPAEYPIAELDGGGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJE3</accession>
    <name>A0A8G1VJE3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_451307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513441.1">
        <property type="nucleotide sequence ID" value="XM_025660559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJE3"/>
    <dbReference type="GeneID" id="37163961"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF44">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="438" mass="48480" checksum="29CDE19398291841" modified="2022-01-19" version="1">MSASLAPSLHDVLADLHNRPYPHVPNPPSCKKRASVALILRVRPTYHHWPDASSVSLPDVSASVPQRLQTFFAQDWVQNGEPEALFIKRASRVGDRWTGHVALPGGKRDPEDVDDKAAAVREALEEIGLDLSTSDCIHVGNLPERVVTSSWGTVPLMVLCPYVFLLTPSDSPTLRLQPTEVASTHWVPLRALLSSSLRTVEHVDMTQRLANMGGLLARLAYRSMMGYMQFSAIRLAPTESLQCNSTPGYLPEGNQPSTSLFQRWKSWCMGSQTHFSNQDRPLLLWGLTLGIMADFLDMLPPHTAVQLWKYPNFTALDLRFIINVLTYRLRKHNRSQVRSGARPSNTAVDSQTAALPVTKTTATNGNAEHNQVGIGGLGVGRYFGSSDTDPSGSAYAVGIMLRGYYERVRIGIYIIVAWRIALGSTAAIYAWKLLRRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJX9</accession>
    <name>A0A8G1VJX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_498343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513848.1">
        <property type="nucleotide sequence ID" value="XM_025664029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJX9"/>
    <dbReference type="GeneID" id="37167431"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF14">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21493" checksum="C839DD0A896074B5" modified="2022-01-19" version="1">MITSNSTFYDHEPLPILRVPTGPEADAEWNRIGGNTKLRPIVISSAEVRKMGKDPARAVKIPEELGYGSDAYIAWTEVFHLLHCVDILRQQVYSDYYASGLHGESHLDHHSHASHCLEVLAESIKCTGNTDPILFAWVEGTPWPSPEFSTQHTCRDFETMLDYVNKNGIPEDVFNAMTGPPPGYVPIPEFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKF9</accession>
    <name>A0A8G1VKF9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_452892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511600.1">
        <property type="nucleotide sequence ID" value="XM_025660930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKF9"/>
    <dbReference type="GeneID" id="37164332"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="515" mass="58599" checksum="38FE746BE4FDF176" modified="2022-01-19" version="1">MSKPFQYNGLFCLPTELLEMLLSYLDINSIKALRLTCNKLAKRCIGPRFLASIQHPLLDVSLENLRSLLALARNPDLRKKVNSITLLATILDIPGLEQNVKDGYYIVTKVDGPRRKRIEVDYSPEELSTAKDDLIWLVEQKEARKNESPSELVKLLEHVLKTFGELDAIHLDGAVVRGRKERRCMRSGEWVPLWTRAAQVFSWVTRALAQSQASVKRFDIYQSNRKYGIEAANIGNHNVTLDLAGLEVPIKGLQSLEMSLSGDVQDALDNGERQEDMQEAEERMARITKEQDSYGTPRLPSFFLKSTPSLRKLELSFRRTATLVSKSFRQKYEWIIHSIAHEARFPMLEECTLAGFSARSDSVLLLFQKSPSIRSLTIHECHLSSGSWTPIFAHLEASMPELQTLDLSNLWGKHMQTVMHTQAHVGDGNDNSREGEADHWQEGDGLVIWHTHSRPQWTRYTSTTGSGVHTICFNHEEIKRGLVSRPLNPGPGRVKSSAELWRWRNKRLRLYGPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKJ9</accession>
    <name>A0A8G1VKJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_503903</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511705.1">
        <property type="nucleotide sequence ID" value="XM_025664265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKJ9"/>
    <dbReference type="GeneID" id="37167667"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="20"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH53783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="532" mass="59426" checksum="47C980A139534217" modified="2022-01-19" version="1">MFNSKSPYFGLRGGWLTFWITLACGADMTLYGYDQGVFSGVVISKDFLRLHNLEGPSKTSLLGTVTAIYDVGCFVGSICAYWLGERLGRRKTVLVGTTVMAVGALLQASSYSVGQMMAGRVIAGIGNGLNTSTAPIWQVETSNVHWRGKLVILENVLVLVGFSLANWLNYGLSFASGPVSWRFPLSFQFIFIIILALTVPWLPESPRWLIAHGQEEAAVQIIADLENKSINDPFVQFQTSEIRYSVEYERANSVSFSDILRGRAHERSGTKTIRRLILGMGAQAMQQFSGINVTSYYLPTVLTKSVGMSEPLARLLTACNSVQYLCFSMIGIPNVERWGRRALLIFGATGQCLCYIFITALIRYNEMPGYPHQHEVASASVAFFFMYYIFFGIGMQGVPWLYPTEINSLTMRTKGAALGAATNWIFNFMVVEITPIGIQNLGWRFYTIWIALNAAMVPVIYVFYPETAGRTLEDMDDYYRGNPPLFVCFDREAISRKRPEKYQARVEHVIRAKEGDMIESAQHVENATAVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKK0</accession>
    <name>A0A8G1VKK0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_460879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513697.1">
        <property type="nucleotide sequence ID" value="XM_025661744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKK0"/>
    <dbReference type="GeneID" id="37165146"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="15964" checksum="81FDF51A3D0ED85D" modified="2022-01-19" version="1">MPLLITTQAAAGVTVGVTFMTCGILFATVTFRLDRDPQLIQVLSDLAWLYFTMLIPMLILQVLLVAQVIRSDRRVQPVVPSWLALTNEFLPSGWFGVLGTHCLHHGPFPWSGGIPFWLTAATYFVHMTLGTAFFWIAAGEIEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKP8</accession>
    <name>A0A8G1VKP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_479385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513847.1">
        <property type="nucleotide sequence ID" value="XM_025662949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKP8"/>
    <dbReference type="GeneID" id="37166351"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH55925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="152" mass="17398" checksum="CA79F11DDA80EEAC" modified="2022-01-19" version="1">MEMTVGACSTPSRAESTTTTALVPSISVWNRSHELRKTSKMYSRPVDGMLLRTFWAKAYPMALRPEDSPRIWDHITGHKPRTRNSTQLGSRGRREAKAFSTRALVKWNDGNVTLERRGFIRRIANGNSFNGDRMIYLKAKELENAFWGHDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKT7</accession>
    <name>A0A8G1VKT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dopa 4,5-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_79552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513594.1">
        <property type="nucleotide sequence ID" value="XM_025665670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKT7"/>
    <dbReference type="GeneID" id="37169072"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1240">
        <property type="entry name" value="DOPA-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023389">
        <property type="entry name" value="DOPA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014980">
        <property type="entry name" value="DOPA_dioxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423:SF2">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08883">
        <property type="entry name" value="DOPA_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143410">
        <property type="entry name" value="DOPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="22463" checksum="29BBDC92E150A1C5" modified="2022-01-19" version="1">MTDQFAYSYPSPLEGYENLEPLSEERNEDGKSLRNPQHGILSKAYEEFPDPLTKGRRGGFDIHIYHFQNNPDQVAFARALWERIRREFPELRIYQFFDRPIGPHPVAMFEVNLFTPAQFGAFVPWLVVNRGPLSALIHPNTVETEEERNHTQRATWLGERIPLDLRLFKLMKEAQKRKELEAEKKAAAEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL85</accession>
    <name>A0A8G1VL85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_514333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515466.1">
        <property type="nucleotide sequence ID" value="XM_025664753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL85"/>
    <dbReference type="GeneID" id="37168155"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="280" mass="30775" checksum="C8AB4C75461380AE" modified="2022-01-19" version="1">MAGLLLLLLPSLILISLPILYTTTIYYTSSISVAESFLSNIWHFYLLEMVCAKLFRSPGKDTVTMEKVLDCNLGNALDCTRVGVPASHDVRRSVFYMGQKNTVIADAAEKDIHGIATMAAHADTHAALSEREVPSIQNPAFSRFCHARRYSSYPAYRLGKMQQQVPSIPIPGLLSPLSSLTDCVGRTGRLTQPQSEREEAATGFIYSDVKPTVLPLETSTDDVPVNTDKPLSEPGHARGGARPSIWISQVPPFSYSPGRLSNVHKLVVRNSLYLGRSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLI5</accession>
    <name>A0A8G1VLI5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_98661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512665.1">
        <property type="nucleotide sequence ID" value="XM_025665825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLI5"/>
    <dbReference type="GeneID" id="37169227"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="161" mass="18653" checksum="2C6FB20FE6EB444E" modified="2022-01-19" version="1">MYAGIDNHPQSPLPFQIHKGSQSTDLTIFPYFIPDILQKKDLLLSTIFELIAFIGGNDQIGLCGWGFSEHLRSTAEPPGSRLLDQRRGFFGTRIFSSIHPICTQNFRMWHAIQREIRRYEVRQENGRRSKSKIASRFMSFLVIRVHVARYVWLEAKGSSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLZ3</accession>
    <name>A0A8G1VLZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_271740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516231.1">
        <property type="nucleotide sequence ID" value="XM_025655100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLZ3"/>
    <dbReference type="GeneID" id="37158502"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034591672" evidence="1">
        <location>
            <begin position="33"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="103" mass="11365" checksum="739764D18F512602" modified="2022-01-19" version="1">MRCRCKRTRLSQNGFWLVLHVTIIPLPPPTGSKDYRSFSCWTAAANKLIVQLRAPPSTAACRRRSSASLVAAHSSFSFCRLLLLALAYSADRCVQSLTLADPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMA2</accession>
    <name>A0A8G1VMA2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_458654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516353.1">
        <property type="nucleotide sequence ID" value="XM_025661599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMA2"/>
    <dbReference type="GeneID" id="37165001"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20626">
        <property type="entry name" value="CYP_Pc22g25500-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="395" mass="45345" checksum="86F45279F3EF4928" modified="2022-01-19" version="1">MFATILKGLAVIILFLFLQHSSIHFFRQKTTMYNTPKLCRLIIAADGQFTNKTNLLSPYESRALFNSRFKRAFCIRNAFTSSDEDFVTQHVKDIKMLINLTPLDWNHLSQSLQESARYWVNSSQGTIHLASITQTLTLRLVLVGIFKLEPKIPPSGDLFFADFARCINESWILAKGPDILSFEGNEELRDCVTAFFPSSDQFQPDENPLNVILPGYETSWRVALRMFLEIRRSRNEVWVDKMVSFALHPTKVQFQENGDGISAEVMVSEALRLYPPTRRIRRTFRFDDGRNGHIWGTNALEYKPSRFATLTEEQKEAYMPFGISPFLCPAKPVFGPRIIGMVVGILFLALQEVGSWRLVGRDKHSANDYVSGERLNNDRSAFDDLFLYLNEEMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMU9</accession>
    <name>A0A8G1VMU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_468711</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516052.1">
        <property type="nucleotide sequence ID" value="XM_025662287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMU9"/>
    <dbReference type="GeneID" id="37165689"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="49"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH58130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="423" mass="48177" checksum="03C6037D6CA88ADF" modified="2022-01-19" version="1">MTLVKDNSTPDMINNTVEYTPIEDVEKLERYRPGGYHPTTIGDWLNGRFRVVHKLGFGAYSTIWMARDQKTEKYVAVKITIADSNPTNSQERNILHRLGIAELKAKTHPGSAIIPSIIDEFTISGPNGVHQCFVTLVGMMNIAEAKDASSVRLFQLPVARAFSAQLVLAVAYLHTQGIVHADLHPGNILILLSESMDSLSPEQFYERHGQPHHEPVTCLDQRPLPDGVPAQAVVPVWLGKASEEVSLSEAQMVVTDFGESFMPATTARHHSNTPDMLVPPETYFEPKKSLSFSADSWTLACTIWEIIVDWVVKEHVDTFGRLPLPWWQKWESRSKWFNEDGTRHGVTNSRPWVQRFNQSVQKPREEFNMQPIGDAERTAFLTMLRDMLAFEPEKRPSAERIMEYKWMQQWALPELSRMEQNMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN52</accession>
    <name>A0A8G1VN52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZZ type zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_449326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="RAH58222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025660142.1"/>
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    <dbReference type="GeneID" id="37163544"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="5">
        <location>
            <begin position="202"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="5">
        <location>
            <begin position="312"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="5">
        <location>
            <begin position="383"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="5">
        <location>
            <begin position="444"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="524"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="710"/>
            <end position="792"/>
        </location>
    </feature>
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            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="754"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH58222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="815" mass="89690" checksum="C8CA104DA19D4D56" modified="2022-01-19" version="1">MASPAPATAPVGPSSLITVKVLYNENTRRFKLPLRELGARTLPQNLRQLLGVPEDVNVIFERYSDSAGCYIQLDSENPAVYKQLYRAAKAKLKLRIKATTAEEPASQSQLAADLPEQQNASRYSYLETVLGAPLPESQVESVPASASLSASALPEVANGTIPAESRSAQWSAPETTEPQFRDFVLGQDSLDMPVVSHASPNGVFCIDCNHCGRSIPNEHYHCSICDDGDYDLCLQCVEASVACLDDEHWLIKRLVKDGQVTNSTTETVQPRKAREEPEPEEEEEETFEESVPELVSETTPVPAVAAPELPESTQERICNDCLKELDETKMVSCADCDDYDICITCLLRDTHGHHPAHTFKLLHDRQFCLKSLVQSRCKPGRHHHHAAICDGCEKRIIGVRHKCLTCPDWDYCSECHQEAAQNHPGHRFAPIYDAIAEPLQSYEVHYGIYCDGPLCRNRPCPSFITGTRYKCSVCHDTDFCAKCEVHPTNTHNRTHPMVMLKTPVHNVSVSTVHEDRGATCALGDRAQKSTSTQASVPVEPVQGTPKLEAEPIQEPAPVEQPTPVAQQPVQVEQPTSADPASGYQAFFIRDTVPDDTTLPPNTAFEQTWTLFNPGPLSWPAGTDVRFVGGDSMFNVNTSHPLSMDAISAAMESNKLSEPLEPGHSADFTVTLRTPSRQGSAISYWRLKLPSGMPFGHRLWCDVRVRDDIPPPAVSVPEPELEKTVEPQPEAQSEPAGSQMIFPKLAKESPETSTHEAATTAPSAPSVTNASEQDVFDDMESLTLGEDETDAGMLTDEEYDILDASDQEYLEAKSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN91</accession>
    <name>A0A8G1VN91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_272788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516264.1">
        <property type="nucleotide sequence ID" value="XM_025655109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN91"/>
    <dbReference type="GeneID" id="37158511"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018853">
        <property type="entry name" value="DUF2457"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10446">
        <property type="entry name" value="DUF2457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="248"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="386"/>
        </location>
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            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="432"/>
        </location>
    </feature>
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        </location>
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            <begin position="554"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="722" mass="80328" checksum="2FF4205764B50FB4" modified="2022-01-19" version="1">MAHLRGGERTFASIHNLLKMLLSPHQSSKSAPQEADMVEDIDEPPDHRFLNTSMNNMDDGVVYVKAPAAMTDRKESLLTRALKSSPPQSPSDRHSPSQEHSFYRSYTYTNISGISTAELTSDGGLTSPSLSNTPSPPLPSHLTNSTSSMGDKRKAEAVEVGESAVEANLGRKRCISFACGRKAQEQKPQTPSPQRPVTKINDASVTPTEPKRRTVLTFVCPARDPETRRERSPLRSGCRPRPRGSPAPMARKASPEKAAPSPVSKAPQEQKIDRRGVPTKGLGKFEESEATRFHEFASSVEEDDEWVTKSGEYPEKITLNDCMKKENAIRKLGEEAEEEALEEDDEDDVEDSDDDSTVHDFSSDDGNESDNEAGFAESDESDDGSEYDFWAPTSTTAATSPQNIDIARLPFSRRDSNTSFDSANDVQQQQRWSPVLAAKTTSRSPMKIPKLRPGTPNLPDSTDFVCGTFDEDRPLEAAYKSCIEQRRLSKQIVIPQDIDPSFPTSDPEDEEDEDDDVEESVMDEGPRGRTGRDSAQKPSPRTSPRRMISPPPRRQGRSSPKRLRSPPPPMKLRSSKDDLASADEAPTVPSRGLNISELVQRPAMSRTKSLPRTPNPFFTSLDKSHRWSGIVPVYESPERESSRTREVHTRGPIDIVEGLEKKRQKRKEKFWRQHCRKAAKEQMVRRPIPGKGAERMKELGLEVAERCRAYGVGENAQLVLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNI9</accession>
    <name>A0A8G1VNI9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_40507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514675.1">
        <property type="nucleotide sequence ID" value="XM_025657290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNI9"/>
    <dbReference type="GeneID" id="37160692"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="142"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="377" mass="42916" checksum="A5874E65A0C6C2BE" modified="2022-01-19" version="1">MLGFKELNCRQVEGRVIIDEDAKEVLPYKFMSLLPKRDNNEYIVPSIKQKEGNQQDSLQPTAELTDEQARLCPASIGCHSLSDMQLYAASVERLTPVAWDVGAMDHLVLDEKKKDILKGLVGQHYNSQDHDMRSDIIDGKGKSLIILLHGPPGVGKTLTAECVSEAVKRPLVSLSIGDLVWEDKRLQQRLQVEFNRARDWNAILLLDEADVVLEARSFEDVRRNGIVTVFLRQLEYFQGVLFLTSNRVSTMDVAFQSRIQIGISFREMTPATRAQIWERLLSLNGRDKMIGPSAVEDVKHRLGKFQLNGRQIRNVLNVADGLAFNEYGIPGKLKYRHIQEAVETAVEFQKMLDESKKRMKNEQTVWAMYRGDNDFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPT2</accession>
    <name>A0A8G1VPT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_193037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519216.1">
        <property type="nucleotide sequence ID" value="XM_025654449.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37157851"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052609">
        <property type="entry name" value="Ribosome_Biogenesis_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682:SF2">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="2">
        <location>
            <begin position="1252"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1484" mass="166658" checksum="DDD04C72D0143BEE" modified="2022-01-19" version="1">MPSVAERPRSSQEALLRLEKGTASPTTQLDEAAQIIGLDLALCASHPEINRTPHVQNNAAPKEEWVLRWLLKKLRAGKNYRVDSTSFLLLRQLIDLIPPKTLATTLKDQKFLAIFNQAIADLEEDVFAALKTGTTDLLPSDSDSSHTLSDSPHRNGDYDKKGTKRKRAGDDEADTMDVDDQPRTPISCFLAFIRALDCLYSLIMLANRTLGVDEVASSHLKHALKGEPEPNAVTLQKSFRLAAVISTQFSHARKTTDLQHLLYVFPAVLELWELRSSRRDDSDKGLSNECFAKHCFQSALRLQVSVRSIRLDTDERAHVLHGVERLIALHVVIPTRGGFYERGGAGIDYSASEPDWSPVKPISDTLRPILCKPECPAETAEDTAVQKKIMWKTAELLPEFFDIAVRSVPRDTFRRQTHEAPWLETLFVAIAELAFSIVKSENTTTYLPEFVGILERLFRVVLVRNVQLSLHTLLTHASYTGLLKDGLSQIEWNLTSLLVELGVDIFLPNSGLSDSTKLLKALLEKIFLHWRSGTPQSNGSYETIKNGIVIPLLRGFVAARDLPTFMEFWYEQLIEVEEARSQNKNLGSFIVWEDDDVCNAYGDVMRSPLTHTFAAAQLKAAAVEIRSEDGKIADAPGAYAQFVILESGFRYRDLSFADKNESLSSVIQTAASTLSSKQKLHWRWRLWRLARNLLENNVQSTDNDLGVAIMNLVDTGAATIRRHHKDLLQKPWAPLECFEAYQFTLAAVKGSLDHDQFKSLTSQITELVKSISDKDASDAIVSPWNGRIETLNRPDTLALAYFLTLVRSPDVWDRVEPETRRSLFGHILSLATSQYKSSPSALETVSPELRYLQAWAGVVCHEYLLNAPAIASDLISVLSSRVKEDITNRKLYVESLQRIPAPLVVRRQRAILLDLLQEVIVQEDSTPEVTVGMLSLMAKLADMPKSAAAVTSNWEPVWTIAKAVTLQGSEVDLQIMKAFRNLHRAVIAKLLVLSDEERQKLFKKMYRKVSSKASKLQTLDRDSMDCFYLRISLSQLWHHRKQLVNVFEETDLAACRQKVFDLVVVEVKSVKDQCKKQQLEETITLIKIIDALEDFEDLATDHAEVEKFLSKIESYVEKSVDSGSSLRRLIRRRVLAGRGSEKSITQPVVQCAEALPLQHMYSEEQRFFIRSTSGRFQSMSVEELTRVIQDVRELGFVGENAEYHLLIAGLAIASLPPIEDKESLTAQELSLVCTAVTESLPRNKSIEQFTLATECLDILLRNYTRCITQWNVDNILGTIAVCASKSGPCIDPEYAGTVYIRLCRLMGVLLGLHRQKLGGRFHLILPVVERLLDCLFARSKKRSRSMLHEKKLGQQPYWLAPLQASHAVHFTRLLTSLCDPTVSAVSRPTQSAGGYEGLTDQTKKAKRIAGQYLQYLIMEYTQSSLRGTLAPEVKAAIVPGLYAVLDVMSRETMRAMNAGLDVSGRAVFKALYDDYVKFGKWNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPY2</accession>
    <name>A0A8G1VPY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_391299</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519351.1">
        <property type="nucleotide sequence ID" value="XM_025656801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPY2"/>
    <dbReference type="GeneID" id="37160203"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF3">
        <property type="entry name" value="AMINO-ACID PERMEASE PB1C11.02-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="55"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH61429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="539" mass="58870" checksum="8AD2D8A4D4B23323" modified="2022-01-19" version="1" fragment="single">MGVHDIEKQRPMAPGEPMAERNAKDPSTLATDYLEPEIPYINANKLARKLSPRQVQMIAIGGTIGTGLFLGTGKALATGGPASMLISYTICGVIVFITMLSLGEMAAFIPVAGSFCTFAGRFVDDALGFALTWNYWFNDAVSTASDIIALQLLLEYWTDNFPGWAISLIFLVVVIALNMLSVKVYGEVEYWLSLLKVVTIIIFIILGIVVNCGANTQHKYIGNKYFYTGEAPFVGGIGGFASVFVTASFAYGGTESIAITAGETKDPAKNLPRVVRNVFWRIILFYIVSIVLIGLDVPYNYPNLSSETTATSPFTIVFVEAGSAVAGSFINAVIMTSVISAANHALFAGSRLLYTLAVDGYAPRFFGHLNRFQVPWVAVLATSVISGLCFGASYIGAGQLWSWLQNIVGVSNQLSWTFIGLASLRFRAAIRKQNLEHLLPYKNWTYPVGPILAIVLNVVLILVQGWSCFSPHFKAVDFVSYYIELPIMLVMFLVWKLVKRTKLVKLEVMDLVTDRWNLEVVGGREVEEDDGVGSSNGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ29</accession>
    <name>A0A8G1VQ29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_445038</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519516.1">
        <property type="nucleotide sequence ID" value="XM_025659169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ29"/>
    <dbReference type="GeneID" id="37162571"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="191"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH61594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="399" mass="45094" checksum="4D98150BB3A5774C" modified="2022-01-19" version="1">MNGFASHGLDEDAFGEKSGLQGGLKTFDAFPKTKPSYTAPSRRGGQWTVLILVICTVFTFSEFRTWLNGSENHHFSVEKGVGHDLQLNLDLVVRMPCDTLDVNIQDASGDRILAGDLLQRERTSWKLWMDKRNRETSGGVHEYQTLSQEDSDRISAREADAHVHHVLGEVRKNPRRKFAKGPRLRRGDTVDSCRIYGSLEGNKVQGDFHITARGHGYRNFGEHLDHGVFNFSHMVTELSFGPHYPTLLNPLDKTIATTETHYYKYQYFLSVVPTLYSKGASALDTYTNHPDLIATNRNRNLVFTNQYAATTQAQELPENPYFIPGIFFKYNIEPILLMISEERTSFLSLLIRLVNTVSGVMVTGGWVYQISGWVGELVNRKRGRGKSEGVLTGKHYAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQM9</accession>
    <name>A0A8G1VQM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA repair protein Rtt107</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_445654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520146.1">
        <property type="nucleotide sequence ID" value="XM_025659315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQM9"/>
    <dbReference type="GeneID" id="37162717"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18436">
        <property type="entry name" value="BRCT_BRC1_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18437">
        <property type="entry name" value="BRCT_BRC1_like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17743">
        <property type="entry name" value="BRCT_BRC1_like_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000066">
        <property type="entry name" value="BRCT domain protein (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000048">
        <property type="entry name" value="DNA repair protein Rtt107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000074">
        <property type="entry name" value="DNA repair protein Rtt107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="107"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="241"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="338"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="629"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="863" mass="96057" checksum="ABC1CCDC8D2AA6AE" modified="2022-01-19" version="1">MAEQGGELQLFSQCKVCIICSKDLSADTAHQLASTFEEHGGETVIYEPPATFPPLSDFTHLISCTIDFPAFDAAGDALIPVVKPHWVHACLAKRKLANPRQYSPDPRLFLNDVVITCGDIPGGDKEAIIGGVLAKGGIYSPKVSQQVTHLVDLTAESDKARLIAAKKLNIKIVLPHWFDDCLKLGRRIDERPYTLPDPEILRAAPDAPIRSSENRDIIGASTTNPANLPSSVKSPDAQPALTVFQDKNVMLSTDLGIGPRLLGSIEDIIKNGGGSITTDVSKADILICRYREGFAYRMASRLNKDVGNLSWLYHLMTYNTWTSPLRRLLHYPVSRSGIPGFKGFKISLSNYVGEARAYLENLITATGAECTKTLKQENTHLVTAHGNSEKCAAAKEWGLQVINHLWLEESYAKWKLQPVSDPRYTHFPKRTNLGEVVGQTRLDRTVLESIFFQSESLAREQESPRRAMQTKEQNTVAAKSSDTMQPPSAKVTESESEVPQQPQIATPRAAGKSRKTATSDNQKLQTPARARLTSEGKENDTPSTTSSRKSKEAATARLHEIAPDIALYEKEKKRVGGVIYGGRRKNDEDRVTLNNGKKRRSMEAEDKSDEEDSTEAKRQKKGKPSVAMHLLITGYQKWVGNPKKEDSDKRQLRELGILVVQDARRCSHLAAPSILRTPKFVNALAYGPAIVSIDFITQCLEQDELLEPADFPLKDDASEKKYGFSLEEAKMNAKKNKNKLLQGYQIHCVETIRGGFDAFKSIVDANGGECSLFRGRVSYRSQREESDESSGDDDRSRKEVYLLSSTSADHTKLWPRFRQMVLNRGKTPRIVRVDWLLDIAMSQTLRAADAYELDEEMADQMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQU4</accession>
    <name>A0A8G1VQU4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_484195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520103.1">
        <property type="nucleotide sequence ID" value="XM_025663219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQU4"/>
    <dbReference type="GeneID" id="37166621"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="128" mass="14270" checksum="B6FC528955CAFEDC" modified="2022-01-19" version="1">MYVIQSRCLSQDWHIPTSDGPRSSIGALNVVQNELQSITKLRQLKFSVPVAPIHQSGCAEEQMVFDLEFPLSDMLVTFTVQYNKERVVPLLTIETTGSCDTGDYSFSAIHPSHYFGPAIIINPQIKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR27</accession>
    <name>A0A8G1VR27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_415001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519382.1">
        <property type="nucleotide sequence ID" value="XM_025657667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR27"/>
    <dbReference type="GeneID" id="37161069"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000285">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="69"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH61460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="533" mass="57590" checksum="B2AE7D9059A2D455" modified="2022-01-19" version="1">MSEFADNNRSEPVLDGSTPYDSESILSRGDLQEKPSNLDDDEDPEALTRLETAQSAVKPPSELWKEIIFIAVVCMAQFMTQAGLCMSIAPAHIIGASFGTTNAGQLSWFAAAYSLTVGTFILVAGRLGDVYGHRLMFIIGFSWFGLWSLLAGFSVWSNKVFFDCCRALQGIGPAMLLPNAIAILGRAYPPGLRKEMIFSCFGATAPGGFIVGGVFSSLFAQLVWWPWAYWVMGMVCFVLAALGILVIPVTHRPKFTDNMTAWLRLDILGAITGISALVLINFAWNQAALVGWQTPYTYALLIVGFVFFGVFVFVERSAPCPLIPRSVLSGDLAWVLGCIAAGWSSFGIIIYYFYQFMEVIKGDSPLLATAKWSAAAPSGAVAALVTGFLLGKLPPSVIMFFAMCFFTAGQAIFATVPVHQTYWAQAFVVSLITSWGMDMSFPSGTLILSNSMHHHHQGLAASLVTTTVNYSISLGLGFAGTVESNVNDGGKNPLKGYRGALYLGIGLAGLGMVTSICFMSVSWRRHRLGKEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSR2</accession>
    <name>A0A8G1VSR2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Allantoin permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_465131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521137.1">
        <property type="nucleotide sequence ID" value="XM_025662035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSR2"/>
    <dbReference type="GeneID" id="37165437"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF4">
        <property type="entry name" value="ALLANTOIN PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH63215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="559" mass="61945" checksum="403F7807130B345C" modified="2022-01-19" version="1">MTLLQWLEVPQEGETIPDRWINSDIEPIQADRRRWGFWTFNNYWVLISSNISGYMTGSSLIALGLSWWQAIVAIVVGNILATIFIVLNSLPGAYYHLGFPVVNRYVWGMYGSQFVIWNRIFLSLIHPSQQILTAKLTTDAFQAWIGGECVYVCLQAIWPSLEKRIPNHMPTDTGMTTAEFVGYIIFMVLSLPVIYVRPHKLQKMFYISAVIVIVFEFVLLIWSLATMGPNGFGDTLASGSKVSGWMIAYGIISTIGSICAGILNQNDYARFARRPRDAIYGQLFSAALYAIIIGVIGILVTAATQERYGEAYWNLPKLLGAVIETGGSRSRAAGFFGGVALIVSQMGVNVPGNALSGGFDLAATFPRYINIRRGAYLTALVSIAANPWRLVNTATVFITVLSSYSVFMAPMIGLMIASYLCVHQRKIKVPDLFVGDAQSIYWYTYGVNWRAIIAWICGTVPSLPGFIAYVNTTIHVPAGLMHLYYICFLSGALIAGAVFAALHYVFPDRRVRSFLASAPTARILIEEYRDQQITVEAVIHVRSPKLSDNEGENAINGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VUZ0</accession>
    <name>A0A8G1VUZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidophosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_359935</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521260.1">
        <property type="nucleotide sequence ID" value="XM_025655531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VUZ0"/>
    <dbReference type="GeneID" id="37158933"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000702">
        <property type="term" value="F:oxidized base lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="589"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="680"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1005"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH63338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1027" mass="112573" checksum="BC92DD625FAE6EDD" modified="2022-01-19" version="1">MCGIIALIQANPSSSAAIDLHEALYLLQHRGQDAAGIATCATGGRIYQLKSNGMAAKVFNDGARVADLPGSMGIGHLRYPTAGSSANAEAQPFYVNSPYGICLAHNGNLINAPELKRYLDIEAHRHINTDSDSELMLNIWADELSETKKARVNTEDLFSSLSRMYERCQGGWACTALLAGFGLLGFRDSYGIRPLVIGSRASLDGEGTDYMMASESVALHQLGFSNIRDIQPGEAVIIEKGCEPIFRQVAPKKSYAPDIFEYVYFARPDSVIDGISVYRSRQRMGDRLAARILDVLGPEVVKDIDVVIPIPETSTTSAAAVARYLDKPYCQGFVKNRYVFRTFIMPEQKTRQKGVRRKLNAMQAEFKDRNVLLVDDSIVRGTTSREIVTMAREAGAKKVYFASCAPEITHAHIYGIDLASPAELVAHNRDTASIAKHIGADSVIYQTLEDLKGACAEIAQENGLSEPRDFEVGVFCGNYITPVSDGYFEHLEKLRGEGRKIKALDRAKEAVTHGFASEKDFRMAANGVKLDGSGNIIPAQDPSESEVPQVSVCTTRKHKEEEHPKVKDLMARMTRSATARETALLAAQMHQKEAQPSKRVTTATSGGRPMKRNGIVGEPAHKRLKTNGRTTRFNDAQELPHNLGSATLLSELPDKSSPIKLDTSDTTIKKEEIDALSNTLQNTVDKATKAASEPREKQKRSKKTNTYGLTPGISPFPDWAHPTPDECEEVNRLLSTVHGEIVAPTTIPEPSLTVTGCGEVPSVLDALIRTLLSGATTGNNSAMAFNGLVQRFGILKEGIGKGSVNWDAVRRAPLKDVFEAIKRGGLADVKSKKIKAILDMVYEENQQRRDMLLKGSQDAPQDLLTKSEGGKQYEIACADQNFLSLNHLHSLATEDAMVELVKYPGIGPKTAACVLLFCLQRPCFAVDTHIFRICKWLGWVPPDKATEITAFSHLEVRIPDHLKYSLHQLLIRHGKSCPRCRAITGQSSAGWEEGCVIDHLVKRTGKRKGGSTESTEEVKPNGRKRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQY7</accession>
    <name>A0A8G1QQY7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M50B-like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_454255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510120.1">
        <property type="nucleotide sequence ID" value="XM_025661240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQY7"/>
    <dbReference type="GeneID" id="37164642"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29119" checksum="CF3B4F213119C06E" modified="2022-01-19" version="1">MAPQYMVLDQRAIDHHIMKRDLSVTHAQAVTLGVMAAYVVVIALLWNLPYVRWSLWPFKMLVIAFHEFGHAITACCTGGRVKSISLDPHEGGVTHMQGGMSAVTLPAGYLGSSIIGSLLIFAGFDIVASKVASIVLGVCFLLTLWWARRDWLTIITILLAVGLLVACWFIAHGEALKWVVLFIGVMSALYSVWDICDDLILRKVNTSDASQFAKRYGGSSQCWGVIWSFISLAFIAIAIIAAIAAFRESFSEQEKDSQHFIPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QR42</accession>
    <name>A0A8G1QR42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_408606</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509996.1">
        <property type="nucleotide sequence ID" value="XM_025657407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QR42"/>
    <dbReference type="GeneID" id="37160809"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF7">
        <property type="entry name" value="P-HYDROXYBENZOATE-M-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="418"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="636" mass="70954" checksum="9E9139C0F1A76830" modified="2022-01-19" version="1">MAPSQQEKYDIVIVGAGPVGIVLSLCMSRWGYKVKHIDNRPVPTATGRADGIQPRSTEILRNLGLKRQIMAFKPAKVYDVAFWDPLPGGQGIHRTGSWPSCPRFIDTRYPFTTLVHQGKIERVFLDEIEKAGTTVERPWTIVGFKNDGLDETYPVEVQLKSIDTNVIETVRTKYLFSGEGARSFIRQQLGIQIQYKDPISYVWGVMDGVVRTNFPDIETKCTIHSDAGSIMVIPREDNMVRLYVQIASSDDPDFDPRKTATAEDVQATARKILQPYWVEWDRVEWYSVYPIGQGISEKYTLDERVFMGGDACHTHSPKAGQGMNTAFHDALNMAWKLHAVESGLAKRSILSTYETERKDIAETLLSFDNKYAALFSKRRPTAGEVGEASHTTAAAGGEEDEFVKTFKSSCEFTSGYGVAYKPNVFTWDATHPAQSPLFDVPGVRLTPGRAFTPTTVTRLADSNHVHLEQEIPANGAFRIFIFAGKQDKTSKAITDLAANLEKERSFLSVYRRSDIADVSFFENHLPHSKLFSICLVYAGEKNQIDVESIPKILRDYHHHLYADNIPDVRVPQATYAAHEKLGFDVEKGGVVVTRPDSHVACTVQLSEGSGTVDALNAFFGSFSTKPLGQDSQHSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRZ3</accession>
    <name>A0A8G1QRZ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS17 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_453846</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510446.1">
        <property type="nucleotide sequence ID" value="XM_025661147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRZ3"/>
    <dbReference type="GeneID" id="37164549"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH52524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="160" mass="18403" checksum="EDF7166E7BD68DA5" modified="2022-01-19" version="1">MATELTVQSERAFQKQPHIFVNPKAQAKSKKVGTGRRWYKDVGLGFRTPKTAIEGSYIDKKCPFTGLVSIRGRILTGRVVSTKMHRTIVIRREYLHYVPKYNRYEKRHKNLAAHVSPAFRVEEGDWVTVGQCRPLSKTVRFNVLRVLPRTGKAVKAFSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS12</accession>
    <name>A0A8G1QS12_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_173402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510705.1">
        <property type="nucleotide sequence ID" value="XM_025654293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QS12"/>
    <dbReference type="GeneID" id="37157695"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="342" mass="38718" checksum="34C512772D2F6638" modified="2022-01-19" version="1">MYPQTPIGYSAPMMFSHGGSNPGDGLDEYYVSMQPRWTALDTSPYTGVSNPYTTAAAFPTGAILTPISLPDSSFRPSPVLSHHSQDFHYNVPESVPPQGLGITAPFPSSFPRTVTAGLGHTSEEPDFGFSEAILSPQPPPAKRIRRGPKQAVTPREAPVTILPNPEGLQRMEQERRQGAADAQNNQRPRAPGRGRRDPQAEEEDAFVERLREQNLAWKVIREMFRNKFHKDASEARLQMRMLRRRKERLARWDENDVIIQIRLLIRAREYWEHEKYNVIAQKMKEFGAGPYTPEQCEAQLRYLDAQNRERSTGPRTRIPDPQPSRKRSWSKVASSVASGSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS49</accession>
    <name>A0A8G1QS49_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_407734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510536.1">
        <property type="nucleotide sequence ID" value="XM_025657375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QS49"/>
    <dbReference type="GeneID" id="37160777"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055589">
        <property type="entry name" value="DUF7165"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23749">
        <property type="entry name" value="DUF7165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="49"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="904"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="657"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="988" mass="109708" checksum="31D258F26B06E59E" modified="2022-01-19" version="1">MEEDVRLPTSERLGGPHLDPDQCPSTTCSLKLHQEPPKSTRPRLEKQTSSPFARLPRTVIEHILYVADANTFASLTLLNRKWRRISDSTLLYAHHLSQCPSFALTQKATEQPAHSSDLTLLKRQFGAQVRRNTFNAFLRPRRTLIKLTSTSMSSSTAFPQGEAFRFSFSPNAQLILCISSSRIVVLDVTSDRAVVKHELKTWRRPLNAAIVDDGSILAVVSSTHRVNIYRLTDDEAKHIQDLTLNDVPRTLALSPTGGVLAIAYDDRIEVYAIGEGALATERRAVRCSGVDSVSFSSDGVMLLGTSAERGNGGLVTITVPFYTESETEYSPRDAQIRMWTTQILFPDITTGFSHACLLPWHAEGEGNWLLGFDEQINTFRAFGVHNTNSGTTYFVTPMSEDGSRETTPIMLPTVDDLGELAAIGFESSGLWVYGIPDRLDIAPVAPNARTYAEMDVEQGPSIEEAATARDSLSRLQQSITKPKVLINGHKMTDMAGMTAARWVRHPNCVAGRRRLVAVAPGGISPPTIGEEDVPVDGGRVLLLDLERSVTDGDSTEVNIEVGDAEPKLLSEPNSTLDTEVELERRRTRLHRGNAASPRARAFARESYPSANSVVHAPRQYARRNSSFFSGSSNSEIQHIPESPYDNTQPRSRDTLRRAATAAANGRGRNNPRYQDEARPVQGQRPATQVFQVPHESDADNWVPPPPPYSRDPDAPLPDYLRRTLLPSNTEPAHRVGDVPEGIQRPQTSRLERMVDESPSRSSLQRLHTITGSRLAARMRRGVRDSESPEPNRRHTMFFRRRSSATGPQPNLQGLDGAHMPVPEQDPAVNFQGQLHPVLSGSTQPNQSSAVQRANYQDVLLEESLLGTTDWQEAMPPTQNGTFNLDHYPYSISSPNLQVSTFQHDAPEGVHGSRQRSTYYRGADRRSQSQNVRLPPGGIPPLNRRASTDPTLSTSSQAAAHDLWRRRIEEWNEQTIYERSKRRSKCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSJ7</accession>
    <name>A0A8G1QSJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_381338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511438.1">
        <property type="nucleotide sequence ID" value="XM_025656414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSJ7"/>
    <dbReference type="GeneID" id="37159816"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="18"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="349" mass="37859" checksum="AB4317DDF5EFCC70" modified="2022-01-19" version="1">MSSTQPTHRRAVRRTDDYTPNNPKVNIVTEPLPLPLSPTAVLIRVHAVALNYRDANIANGGNPWPVLPHGILGNDAAGEVIATGDKVKTLAVGDRAAPITDTEQITERATKRSWLAADEDGVMADYIVYDESVLCKLPTYLDWVQASMIPCAGVTAWSALKGMRIGQTVLVQGTGGVSMFALKLALAAGLRVILTSSSDTKLKAIKEKYSGSAILTVNYRNTPEWDEEVLKLTDGVGVDLVVENGGTGSLVKSMRCTRRGGVVSQVGYLGKQDPSELRELVPTLIDRRINLRGINAGSKIDMEDFCEALSASQTQLDDLIDKVFPFEQAEEAVEYVWQGRQVGKVVLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSQ1</accession>
    <name>A0A8G1QSQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_158729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511080.1">
        <property type="nucleotide sequence ID" value="XM_025654214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSQ1"/>
    <dbReference type="GeneID" id="37157616"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="167" mass="19032" checksum="AF91A73ACA3B29E9" modified="2022-01-19" version="1">MTIERNPDPFIFFLVFHTFQSDRCSIFPILFYFPFYSLAFLQLSLSSSLFFSLLHCFLASHTFRSLSLLSPSPPHPLPYYRNHIRYSIALSTPFPRTIDSSNQFLGGHSPPDSIQPASASNSNNLLTPLPLSTVQPHSLPGSCRRPFCPIRPILASILSSWTWYLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTX2</accession>
    <name>A0A8G1QTX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Gluconokinase</fullName>
            <ecNumber evidence="3 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_507373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3 9"/>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510421.1">
        <property type="nucleotide sequence ID" value="XM_025664404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTX2"/>
    <dbReference type="GeneID" id="37167806"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH52499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="145" mass="16532" checksum="5C3DFEF3614F4BC7" modified="2022-01-19" version="1">MRNGVPLADEDRWDWLIALREATLQALSPSQRNNFHPPNSVIVSCSALKEKYREVMRIAAYGSSQIKIHFIYLKVSEVTLMQRVNLREGHYMKSNMVRSQLQALEEPQKSEWDVTTITVEGSAEQVQRHVLSLVCSGITKGSQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUC5</accession>
    <name>A0A8G1QUC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_463270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510929.1">
        <property type="nucleotide sequence ID" value="XM_025661914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUC5"/>
    <dbReference type="GeneID" id="37165316"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH53007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="375" mass="42510" checksum="4FC153E0D884C860" modified="2022-01-19" version="1">MNEDERLKERYVNFDPIQLQRVAGKAMGEDHCAHIFKLADGGFNKVFLFRTTSGKEVIARIPTPIAGPPHYTTPSEVATMAFLRDILGVPVPRVLAYSADSTNPVGSRKLKRGFLQDFCIGPIAARQFWHGDRSNTKIDRGPWLSPEDCFTSAARRETTCILHFDIDPSEHTSLLSKFLQLSTLLIPKDTVYNALILRHFDLTLNDILMEPGSAKVASIIDCEEQMEAKAKFRSEEANLHYTSATWLYNGNHWSALKIPHLGMRQYLHQQAGYLWDGDVINLRAALVGITTPQVWDAITSERCPVVFSDQERHTAMEEANEWNQCEELLDFIRNDLGIDPEGGTEPANFEEDERDICWRNWPFKDDTDLPSSSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUP5</accession>
    <name>A0A8G1QUP5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_155892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511233.1">
        <property type="nucleotide sequence ID" value="XM_025654188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUP5"/>
    <dbReference type="GeneID" id="37157590"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24059" checksum="1A0275C7C8FD8E69" modified="2022-01-19" version="1">MQGPGASFGEPERRRRIAQISDKMKFSLAAPTARACLWLADLENLREIAGKSAEELLHFLIAVEHFNLVKKWTQRDADSQSIITSTIPSPSCKRMEDKHQPIPGVPDPATAMQSTTMHSPETLRVRTEQLDSGNQRESKTSPADTPCSTPVHTPRKHPAEPLESPGLYKRIRRDESVKKACRERNSSYIITKIPVEFCDITHLYPFSLKDKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVF7</accession>
    <name>A0A8G1QVF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptide transporter MTD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_427376</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512300.1">
        <property type="nucleotide sequence ID" value="XM_025658150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVF7"/>
    <dbReference type="GeneID" id="37161552"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="657"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="695"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="732"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH54378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="789" mass="89208" checksum="BE48E9DA85BA397E" modified="2022-01-19" version="1">MEAKSASVSPEQEIPSYNEKSSQESPALEPQVLEKGQTVRIGEDDDYDSDQVVSTAQDLVTHIIKVEDDPSLNPWSFRMVFLGAGLSIFGGVLQEIFYFKPQTIYVSQVFLTVIAYILGELMAYVIPRRGVIGKLLNPGPFNAKEHAAISLMSSAATQSALATEALSAQQLFYGGYPNHAAAVFIVLSSQLIGFGIAGLLRDVIVRPTKMIWPMTLPISSLLESLHKDKAQSKARLKIFYIFFCILFFWTIIPEYIFPLLEGFSIFCLADQHSLVFTNLFGGASGNEGLGFLSLSFDWNYIASLGSPLWYPLYAMTNNFIGYLGCIILFMAVYYGNIWRSQDFPFLSQLLYYGDSNSTSYNEYNQTLILNSEYIVDHAALKEQGLPWLTGTYVVYLITSNMGVTATLTHMLLWDFDDIKVGWAWAAPSKLKKWLKLETYKFWKNQETPEERLARRVNDETLDPHYRLMLRNLYQDTPLWWWGAVLIASFVVGLGCLYAMKSTLPWWGFIVGNILTLVFMLFFGAQYGLTGFQFNVQPICQMLAGYMFPGKPLANLYFTCFTYNSLQQGQVLAKDLRLAQQVHLSPKCTFFVQVMGCIIGALFNYVMMLIIVRNQSEVLISIDGTNIWSGANVQQFNSLAIAWSIANDMFSIGGRYEWVTIAYLVGFIVPVPFWLANRYYPHPIFSYLNTSIILWYMGWLFVGINASIMSYFLLGFAAQFWLRRYHPQLFNKYNYIVSAALDGGTQICVFILTFAVFGGSGVEHAFPTWAGNPNTNIHNLDYCKVNPATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVU8</accession>
    <name>A0A8G1QVU8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Large ribosomal subunit protein uL6m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_451642</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513253.1">
        <property type="nucleotide sequence ID" value="XM_025660635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVU8"/>
    <dbReference type="GeneID" id="37164037"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000006">
        <property type="entry name" value="50S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000009">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_uL6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="11">
        <location>
            <begin position="83"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="11">
        <location>
            <begin position="177"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH55331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="253" mass="27946" checksum="1B6901AE44F36743" modified="2022-01-19" version="1">MSCYLSQSCFRQLARGPLRQGPLPNFLVPAFSHPLRTQSFSTTSPVQSRVGGAAITVPPEVSLKFIDLPQPKTKAKSVDFPNMAVEVKGPLGELSLNVPSYVKIDYDEALRKATLAVQDSEITHQRAMWGTMRAHLQNHILGVSEGHICILSFVGVGYRATIEPTATTVEPQYPGQQFVSLKVGYSHPIELGIPKGVKASTPQPTRILLESVDKQLVTKFAAEIREWRKPEPYKGKGIFVNGETIKLKDKKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVW8</accession>
    <name>A0A8G1QVW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_83860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513283.1">
        <property type="nucleotide sequence ID" value="XM_025665719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVW8"/>
    <dbReference type="GeneID" id="37169121"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034738488" evidence="1">
        <location>
            <begin position="17"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="111" mass="11408" checksum="556D33D556E44E8C" modified="2022-01-19" version="1">MRSIIWLSALIGLAIAVPGASIPEENDKREWLDGYGRGGGDGYGGGGGDGYGLAKREWLDCYGRGGGDGYGRGGSDGYGRGGDGYGRGGGYWKVMPLPSGLCSSEHANETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVZ3</accession>
    <name>A0A8G1QVZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_522601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512606.1">
        <property type="nucleotide sequence ID" value="XM_025665276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVZ3"/>
    <dbReference type="GeneID" id="37168678"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="186" mass="20224" checksum="5E07C5A341736A49" modified="2022-01-19" version="1">MDSIKQTMGTTPNHTEEEQRKLYDNLPAEQRDKQSFTEWVKEAYNEQYEKWMPWLEDQYLKWFGKGDNKASYVTKDNLSKTKVTGVKQVDQIQDDVNNLVGNQLGENGLLAPVGNMVSKEGFNRAERGGKDENGSYGGPLGGATDPIVDNSKKAGQGLATGIQSAGSSVASGAKSWGSAIPGFGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QW34</accession>
    <name>A0A8G1QW34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_201393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510387.1">
        <property type="nucleotide sequence ID" value="XM_025654536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QW34"/>
    <dbReference type="GeneID" id="37157938"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF1">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034669088" evidence="1">
        <location>
            <begin position="19"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="380" mass="41737" checksum="34B9EE2F84CD290B" modified="2022-01-19" version="1">MIASAIYVLLGLVSIVASSPSQLTLTSTTAYLDNAKCAVNTLQKWYNQTTGLWGTTGWWNSAICLTVLGDLTALDPSMLNSSSVIFDNTFIQAPKSTLSHSVRKPTSKYKRQSPLNDTESSTEFLNDYYDDEGWWALAWIQAYDLTQDQRYLDTAVNIFDDMAAGWDTTCGGIWWDKSHTGNNAIENELFLSVAAHLGRRKTDNASYYLDWAMKEWEWFKNSGLINSQNTINDGLDLTSCQNNNGTVWSYNQGVVLGGLVELSQLVSNTSYITTAQRIAKAAIQTLSDANGVLQESCDPNCTGDAPQFKGILMRNLQMLYRASPDDGVKQFLQQNANSIWQNDQGDGNQLGPVWSGPFTAADASTQSSACEALVAAAAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX86</accession>
    <name>A0A8G1QX86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_83934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513296.1">
        <property type="nucleotide sequence ID" value="XM_025665720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX86"/>
    <dbReference type="GeneID" id="37169122"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH55374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="54" mass="5962" checksum="327295BC4C412A7B" modified="2022-01-19" version="1">MIQILVESLDCLLETWASSPSLLSQHNCCPSHVSTRFCVVHLDYSGATEAIMHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYF5</accession>
    <name>A0A8G1QYF5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_422579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514633.1">
        <property type="nucleotide sequence ID" value="XM_025657972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYF5"/>
    <dbReference type="GeneID" id="37161374"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034323750" evidence="1">
        <location>
            <begin position="22"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="225" mass="23445" checksum="F62E60B1D2EFA779" modified="2022-01-19" version="1">MYTRTQVLAALAALGATGVNAAMGPAFSTGPVSDDSFIREATSTLVLPNGPSGGSSDAITSLWVGMGTSNGDLIQSIADNWQQSDWTMYAYTLKETSATSQEPIYGDGQADGTKGDKVTMHYKFDDSTGNYTQTVLINGKTVSTLSTSDGKAQGWGSAVECAEDNCGTVGAHSWTNTKIILDVADPNYINTLAKGSGVTGDMSTSDGGKTWTVTTINIPEFSFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYP2</accession>
    <name>A0A8G1QYP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_441031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512507.1">
        <property type="nucleotide sequence ID" value="XM_025658794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYP2"/>
    <dbReference type="GeneID" id="37162196"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034603501" evidence="1">
        <location>
            <begin position="19"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="338" mass="36640" checksum="900FC7B292609EA3" modified="2022-01-19" version="1">MKSLFLSTVASLVFAVGASSMLAASSIDQHASDLLKGDCDRECMAFIVDQVLASMVVHNPYILPMAAIYQATENSHPAALGMMTAWRTVTEAGPPSLLAIDTTQGSAYFALDVSEGSDTERSILRGRVKVVNQEITELELFINRYRGDHGFSFSAAELPSNYEALMSPPDNRTKASRAALTALSEALFATSSNMSVRVDANCQFTEIGWKVIDTGTYNNETATPLSCSWPSDHPTDENARVGLVIDEELGFVVTSGMIQGKVYPYQNVSAFIPDAMTSSQEAQNVWLNEVKARGVKGLLAPTEATGETLEVLQYYNDALQAMQINVYMSGPNMTSAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ13</accession>
    <name>A0A8G1QZ13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">von Willebrand and RING finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_376474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513404.1">
        <property type="nucleotide sequence ID" value="XM_025656225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ13"/>
    <dbReference type="GeneID" id="37159627"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000014">
        <property type="entry name" value="von Willebrand and RING finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="496"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="808"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="869"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="888"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH55482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1011" mass="111669" checksum="B1CC16193DE2383D" modified="2022-01-19" version="1">MAGLMDVDRSRTRRDRTFVGTECAICDEPLEHTLRGERVLQFSCTHVSHEACFYEYIREFEGQYCPTCDAPLGLDTSRGGNMLDLEKLSNIVRSVTSDAATHRSGMSNLPPWEPVPVQARRPSDAGSHAGSRQPNRDSRDTYVRRDSRDNSSHRERVERLTMGSRQHHSRNGSVAGSSDYNESHQHAANGRRHDYDVQAMESDLSPRPVVTKNPIPAPTVTIRSEFPTLNRSRQQQSLTCLITLEVPEGSWQPDESDFTSNGKDQPQDEPYGVGRYPPSQEPKPIPYESQENLDDLAEDLRNKVDNWHGLEFNRFGKLRLHGHMSVGKDRTSWQELECYLFGEMLICVKEKKNTQRRPYDDDQSKPKPTRCTLKGSILIKKHLNSMEAAADEPILALNLSVSELPCFYLRFQNRSQLELWRRSLLDLHPIESTSPNNDYDYDNSGAEEEEYRNNPIKRQASINSSYGAARSINTAITDYTNMGTESPAPSIHIPLDLVVVIPVSSSMQGLKITLLRDALRFLVQNLGPRDRMGLVTFGSSSGGVPIVGMTTKSWGGWPKILESIRPVGQKSLRADVVEGANVAMDMLMQRKSSNPISTILLISDTSTSDPDSVDFVVSRAEAAKVNIHSFGLGLTHKPDTIIELSTRTKGSYVYVKDWMMLRECVAGCLGALQTTSHQNVKLKLRLPEGSPAKFVKISGALHTTKRATGRDAEAALGDLRFGDKRDVLVQLVIPPDNSTSEVTPQDAWESLVSGLEALGGMSDGDDQRVASVEEVPLIQADLTYGDFLRDGHLTHSPRPSLLAITMLPPNPKAKPGRPSSPPIPPHPSIVQRRMELLTSDMLTRALTLVSRGQHDRAQHLLTETRSILKGLGKGGLPPLPPGARPAGTSDSGSRADTPTSSSPKSSMFDGHSSAASDTATITSVSAVDGQTMTALDSDLQSALEWINHPAVFSRDSRKAVLQGIGVISSQRAYTFRSPSEAHWAQRVAGVRRLTERSKEWRETGDDALTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZD7</accession>
    <name>A0A8G1QZD7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_470117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513708.1">
        <property type="nucleotide sequence ID" value="XM_025662373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZD7"/>
    <dbReference type="GeneID" id="37165775"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH55786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="42283" checksum="89A0226AFBCF5B0A" modified="2022-01-19" version="1">MPIIDWVFSLFPRYSREKRLSSLELLPRELLLHIGNLLTTADIICLCLCSRTQNLFTTSFYDIKPPQDKSLTLLVLTRLTRDLPKMFCCHYCAKLHRITDVLHPARSMGFRHRCPDLGVWHRKCPQPSIRWLLAVHCMTTLYDFRHCHLVAVLQNHHSGGRYGINAESLAFTEVVDYPRQPARTTLLSVEGRVCTPAGARQRPSLVLQIQQWVLVHDLQVFSDRGLDVVLSVLHNWFICNWLRVGHKSIQDKIRPANRQRNLCWKEAPLTEIMRCSHCGVEFQIVLRDCGEDGTAVTITKWLDLGAGTDIDDPKWKKATFTNTMESIYDRVEATASTGEVIFDRKTIPLGNVVLLGIYVLSIPSLALNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZG5</accession>
    <name>A0A8G1QZG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_66850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513753.1">
        <property type="nucleotide sequence ID" value="XM_025665578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZG5"/>
    <dbReference type="GeneID" id="37168980"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="12" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="445"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="697"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="767"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="813"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="853"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="895"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="935"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="122"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="222"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="341"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="528"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH55831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1045" mass="115395" checksum="0FE0F7162A444C25" modified="2022-01-19" version="1">MEEDGNGRGLGPGSPSTSVGQFSFAPATRTTVVTTTTTTTTTFPPVLIRPPRATQDLDPKVYPLASAPTPSALRNIRFELGGKSVVFNEPEDTAGTLNELHEKNDALKTSNGLVRSVASFTSDDTQLSRRLAHRTSNQPSNHLSISKRRLTEAQQGSLRARSARVPSEPSFRPARSHGSTPVHPTVAGLATPETETNSNNAMEGILSRRRIHSASNARRETLLRSPLSSEVESQGPSQTVDARKETLRTNTIMQEHDRQSGCSNETGFARPALERTGSDPREHLTGIAASQDSGYDAPGDNSQNLPTESSSQPFIDNIVAQDMCLPSPSLSPVAALNAANIDSSSDSAEDQEDTDSSFDNSDSRFIGPLPVGDSNGEATYVAKPEQLAGPMMQRPTSMMDIPNVLDFFDSVPDSMKTYMMYQFLRRCPKQTLHFVADVVNPALKCDFLSLLPLELSLNIVKYFDVQTMCRAAQVSKKWRHIINSDEKSWKELFDRDGYVLPEGELDRAIREGWGWQFPNGCEDYEKDMSMSPFIKPDPESSVPALQSFGESSDRTLSVSRRPKRKACTRVSSRKLSKRKISSSGTDHSESSDWRKEVSASEGPYAAANAAAAAVPYPDIGLPSLRGLHLYKSLYQRHHSIHRAWMKPVVKPRHIAFRAHDRHVVTCLQFDTEKVLTGSDDTNINVYDTRTGELKATLEGHEGGVWALEYYGNTLVSGSTDRSVRVWDIEKARCTQIFHGHTSTVRCLQIVLPVEVGKKADGTPEMMPKEPLIITGSRDSNLRVWKLPKPGDPGYYQSGPHVDDTDCPYFVRVLTGHQHSVRAIAAHGDTLVSGSYDCTVRVWRISTGETVHRLQGHTLKVYSVVLDHKRNRCISGSMDNMVKVWSLETGSILYNLEGHTSLVGLLDLKCDRLVSAAADSTLRIWDPETGQCRNMLSAHTGAITCFQHDGQKVISGSDRTLKMWDVKTGDCVRDLLTDLSGVWQVKFNDRRCVAAVQRDSLTYIEVLDFGASRDGVPSEQLGRRIVVNRWGQEVSDTDEDYDLSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZN8</accession>
    <name>A0A8G1QZN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_375946</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="RAH55936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025656199.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="37159601"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="493"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="109"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH55936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="554" mass="62150" checksum="76AF05CB11FE276C" modified="2022-01-19" version="1">MELFRDTTFGKLIRVLTRGRVLPYPEETCPSAWSLYVQHSQDPHDPEFSLEPTDSYGLYTVLSQATQSRSYDTPESVVKVGDDFKIITWRESGDSENPQNWSLSRKVFVSLQIWVLTFAIYIGSAIYTPGIPGVSEQFHVSTVAATLGLTLFVLGYGIGPMLWSPLGELPVIGRTPIYMTTLTVFVFFNFAVIYAKNFGMFLAFRFLTGMFGSPVLASGAASMGDIWDSRVRDYMIAIWGCFAVSAPVLGPVIGGFASSAMGWTWTIWPLLWMSGAVLVCCFIFLPETFAPNILYRRARRLRKITGNQNLFCEAEIELSNMKKTSVVFEALIRPFQLCFTEPIVFLMNLYIALIYGILYIWFEAFPIVFEELRGFNPGENGLAFLGCLVGACCVAVPGYFYWKYKWQSKHIDSNGNLAPEQQLPPACFGAVCLPISLFWFGWTGNFASIHWIAPVLASLVFTVGAVLIFNAIFCYQTHAYPKYAASVLAGNDFFRSSFGAGFPLFATAMFHNLGIGWACTLLGCLCVVFLPYPFFLYFRGRRFRLASKFARHDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZS0</accession>
    <name>A0A8G1QZS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcium/calmodulin dependent protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_422958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514815.1">
        <property type="nucleotide sequence ID" value="XM_025657996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZS0"/>
    <dbReference type="GeneID" id="37161398"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000995">
        <property type="entry name" value="BcCMK3, calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000447">
        <property type="entry name" value="Calcium/calmodulin dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="77"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
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        <location>
            <begin position="501"/>
            <end position="586"/>
        </location>
    </feature>
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        <location>
            <begin position="725"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="725"/>
            <end position="746"/>
        </location>
    </feature>
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        <location>
            <begin position="766"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="796"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH56893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="807" mass="90278" checksum="EC5275B212A26084" modified="2022-01-19" version="1">MASGDAELPQQDASPITTKRPPLPPFRCVSTPSYESPQRHHRRNPIVRRPVKETLNARSEYYTSQDDGTAEHRINQYVIKQEIGRGSFGAVHLATDQFGNEYAVKEFSKARLRKRAQSHLLRRPRGPKRPSDGFNSPLHRRPPGGDEHKENALYLIKEEIAIMKKLNHNNLVSLIEVLDDPTEDSLYMVMEMCKKGVIMKVGLEERADPYDDDQCRCWFRDLILGIEYLHAQGIVHRDIKPDNCLLTSDDVLKVVDFGVSEMFEKDSNMFTAKSAGSPAFLPPELCVVRHGDVSGKATDIWSMGVTLYCLRYGRLPFEKQSIFELYEAIKNDPVVCEGETDENFKDLMFRILEKDPAKRITMEELREHPWVTKNGLDPLLPESENTAEIVGLPTEEEMNSAITKTIGHVMAVIKAVTHFKRLIDPAKADPPMQSILGQEYETHFVEPPMEMEPEESFTASGNMPILNKSQSLNMYNRRPWERDNVLQGFHQRRDDLIPNQLTDSSESLSHHSKPGPAPGNNGRIASRMEPERKDSGSIRSHNIAGGSIDEFQSNSNPQSPSPFVPLSRASSVTTKRSVEGTRGHARDPLEEEFPFLYIGPSTYTGSSNEPNMDADTDPIFEEPDNMISAEPDEMDVDVSHPIVSESPGAADFDIYETAYRQEIERIRTRTLPRQGTIPKMYLTRRVEGRDDVKKLVGQHSPDSPIASGRKNTGLSLSSAVSAIRLQLEQQQRQQEQKAQQAAENQKPAPLRPSVPSASGGIPEPVASLSAAAGTTTTSGPETSNPSDISSTTRLRSLLDRVRSSQDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZU4</accession>
    <name>A0A8G1QZU4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_450155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514691.1">
        <property type="nucleotide sequence ID" value="XM_025660308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZU4"/>
    <dbReference type="GeneID" id="37163710"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="499"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="623" mass="70095" checksum="DDA2E5FB18195464" modified="2022-01-19" version="1">MDPIEPVNGSPDPHEGQPPSATPSPGPTSYPRQRAASLRSRRPSIRLQRLPSFEQATLSTPRSQPSQQNGDTSRTPGVALSPLPSIPAASTEDESWQGNRRRSNSEPRPGRWSTPNPAALARVTTGGQMRPVQEEASSPIVSSTSNQRMPEDVPPLPEIPRRGSRTPMRWASGVGGNRFTRNRASTVGGSAPAQNHDVDDEYRSHIVDVLDVIDPEVSALSTLTNVQNSLFIPNLGPLLNRNQTYTLSPPSPMRELESTSDEERADEIKEPEVRPSVEHTLTSVIGEGEEPRFAVLPEGSNLAGWSPEEIEELNDHVRHMLHSRRSKFKRSMKGFRKYVSKPLGFLVTLYATLITLFGLAWVLFLIGWINVGGRQSYIINVIDNVLVALFAIMGDGLAPFRAIDTYHMIFIARYTFLTWKIRRKRHLPDLKNKNDLPSRRETDVDVELGDTPKGEEYEFTVLDPVRQLKLIHHQNKLSKSHTFYKPHETFTHYAFPMRLLIAIVVLLDCHSLFQIALGTCTWAISYHVRPFALTTVILCCSICCNITGGVLIMIGDRMTRKKDVVERLFRQQLTEEAMKKIRKKKRKEEERRNAENSGVSRSHSISSQRKLSLSQPREDGYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZZ1</accession>
    <name>A0A8G1QZZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_58533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514023.1">
        <property type="nucleotide sequence ID" value="XM_025665505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZZ1"/>
    <dbReference type="GeneID" id="37168907"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039632">
        <property type="entry name" value="TMEM42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="28"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH56101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="160" mass="17061" checksum="AAA51F7C142FB5CB" modified="2022-01-19" version="1">MTDPQSPSQSPPPPPSPIQQQKHHHQTKWLLLALSSGAFAALNGLFAKLTTDTATTTFAAHLIHLFSSTSTLDDHPILILLIRALCFGLNILSNIIMWALFTRALTAGSSTTKVSITNTAANFLVTAVLGIGVFGERVGGWWWVGAGLMGVGCVIVGRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R040</accession>
    <name>A0A8G1R040_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_450715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513989.1">
        <property type="nucleotide sequence ID" value="XM_025660443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R040"/>
    <dbReference type="GeneID" id="37163845"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031563">
        <property type="entry name" value="MOT1/MOT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970:SF9">
        <property type="entry name" value="MOLYBDATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16983">
        <property type="entry name" value="MFS_MOT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="438" mass="46584" checksum="16388B4752FFA4A4" modified="2022-01-19" version="1">MNLRQINAHNLSTFRHHYVSEISGSLGDLGTFLPIAIALAVNNTVSLSSTLIFSGLFNILTGVFFGIPLPVQPMKAIAAVAIARSFTNGSIAAAGLFVAAFILLFSITGLLTRFANAIPIPIIKGIQVGAGLSLIIASCNSLLSNLSWLSPSWADNRLWALAAFCFLLSTTVYRTVPYALFVFLLGLLFALILATLASDLPSLSLWHPYTVLPTPSDWSSGIFDAGIGQIPLTTLNSIVAVVHLAHDLLPTHTNSSHLNVTSIALSVSAMNLLGCWFGAMPVCHGSGGLAAQYRFGARSGASIIFLGVFKLVIGVFFGESLVGLLKRFPTALLGVMVIAAGMELLSVGESLNTTGARDIRKAVAGQAGLTGEDLGPMLSDFERKKRWMVMMVTVGLLVGFKNDAVGFLGGLLCHWAFGIPAAVEWGARRWREGRVRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0C2</accession>
    <name>A0A8G1R0C2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-dependent oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_403190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512532.1">
        <property type="nucleotide sequence ID" value="XM_025657214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0C2"/>
    <dbReference type="GeneID" id="37160616"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF9">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034258403" evidence="6">
        <location>
            <begin position="22"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="65"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH54610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="500" mass="54661" checksum="72B744A8978F0134" modified="2022-01-19" version="1">MFRLKMEVLTAVAAWAFATVSQQIHRSSSWESDLKTLSGRLSNTSQVYFPGSSGFTNATTRWSVLDEPEVNVVVVPGTENDVAEIVKFANQKDVPFLTYNGVHGALISLGEMTHGIAIYMGQLSSVEVAADGKTATIGGGTMSKEVTDQLWAAGKQTVTGTCECVSLVGPALGGGHGWLQGHHGLVLDQFVSMNIVLANGTLTYIDANSDLWWAVKGAGHNFGIVTSLTMKVYDIEYSDWAIETLTFSGDKVAEVYQAANDYLIKNGTQAAGVINWSYWMNNADADPNNPVIIFYIIQEGVKTVDSVYTAPFRKIGPISVSPNNGTYKDLAAWTEVAVDSAPCQKMGMANPRYPIYLETYNVTAQQTAWDVYANATRGSSAFNNSIFMFEGYSVGGVHDIDSRSSAFAFRNENVLAAPMINYFPDGAELDRRGANLGQELRNILFAGTDREDIRAYVNYAHGDETPQQLYGSEGWRQQRLRSLKAKYDPTGKFSYYAPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0Q1</accession>
    <name>A0A8G1R0Q1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efflux pump dotC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dothistromin biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_374422</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Efflux pump; part of the gene cluster that mediates the biosynthesis of dothistromin (DOTH), a polyketide toxin very similar in structure to the aflatoxin precursor, versicolorin B. One function of dotC may be to transport early-stage dothistromin biosynthetic intermediates from the cytoplasm into vacuoles, thereby affecting the rate of dothistromin production.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514428.1">
        <property type="nucleotide sequence ID" value="XM_025656127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0Q1"/>
    <dbReference type="GeneID" id="37159529"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF158">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14490)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="55"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH56506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="567" mass="61158" checksum="1F3C326FC0A55E48" modified="2022-01-19" version="1">MLSTSGTVSENYGPDQCGSENIVSNAQDLETPPHGPQSDEPETRGPRSNWKIFATMLALSLALFISALDQTIVATATPTISSDLHSASGYVWIGGAYLLANAASSNIWANLSDIWGRKPILLTAVALFFIASIICAKANGMPMLITGRGIQGIAGGGLIQLITITISDLFSVRLRSLFLGLIEFIWAIAGALGPIVGGAFTQSVSWRWIFWINLPVCGTAFVLLYVFLDIHNPKTPVLAGIKAVDWWGSFSMLALIILLLLGLDFGGATFPWGSPKVICLIAFGCLMSFAFIYSEKKLAKYPLMPLGVFRNRSNVACFLLDFTHGFVYLGAEYYLPLYFQSAKEYTPFRSGVLILPFVLTEAAFSLFSGLLIHRTGRYLEIIWAGTAIVVLGVGLFTNYSATSSLGKIVGYQITAGMGCGMLFFPPLLALQSNITQANTASATATFGFIRNVAMAMSVVLGGVVFQNSMDMRQDGLKAAGLSSSLLAEFSGTEAAANVDAVRAVQDPTQRHAVADAYAWSLRNMWIMYACLAACGFVASVFITRQHLSEEHVETKTGLKEKQPVLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0X3</accession>
    <name>A0A8G1R0X3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_55178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514533.1">
        <property type="nucleotide sequence ID" value="XM_025665478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0X3"/>
    <dbReference type="GeneID" id="37168880"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="356" mass="39220" checksum="565C23A236D96E56" modified="2022-01-19" version="1">MLQQRIVLLRPRRARAIEGTFSSFRRFSATYLQAKDSNNHSNANATEGPAASSAAGRPSAQTRRNNIPPANLNIRSVNHERPRPRRIVDARSLAASQATGQPANILKNPRARNPRGNRSTASRGPRAEPKKKVQAKDGRARRPRRTEGSGQEDSISNAAFHEASINAVFRELAEQAQPKPVQYNPESISLASLKETWPSLPTDIDAHTAGVVEKLSLFGDRYPNDYVPPNELGKRLYQGKFVRFSSEEEKAEAISEANKLSQERADKLSQRKGDLLEPRHVNFSPLSTKDQGSLLGLLVQGNYPKSKAKQGDNLSIVDSVSENLRNNATYHTVGKSSAFIAKLDSLLAASRMTKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1J6</accession>
    <name>A0A8G1R1J6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein RIX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_520932</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514754.1">
        <property type="nucleotide sequence ID" value="XM_025665176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1J6"/>
    <dbReference type="GeneID" id="37168578"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein RIX1 N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="630"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="711"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="740"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH56832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="779" mass="84077" checksum="A665DD03072A2248" modified="2022-01-19" version="1">MAYMSMSLHAVNHRLTNVPVKQLPHLASCLASSISNCGELLSTPQSQKSGKTDSDNAVQIHKLITRLGSLLQDRTYEGRWTAVVLVKALVEAGQWEILRSSEPFVRGLISILAKSDPISTKKMCIITLTRIFHLTYQYPTLVREITTPALPGFITSALNLISVKPSSEPVRKLKPNTPFVEVVLQAVNELIARHPTIFRPFTAQIHSLLQVIIGSTSPTFPEHVLEIAQQLFISLHNCAPKNTGGDEWKSACRMTITSVHAASSYVLRAVVEQWESVDLSLRQMSQPQNYSQEVGNGPDALGLEGWQGLNSGVNRLVVLLRMLSEFVGTATASTVTIPVGAILDLTSRLNMVVYPSGSSDIQANPQIGRAEREQLLTELPRIHIACMKLLLDLVNALETSAIPVAQTILEQALWVFRAEQFSRDVRTAVYDLVCALLTRIGPSMTKQSVSSIAFIIRKCCHDLLPPTGNQNAATEKPDPKSKNKSSSQATVNADSFLNPGLKQVRQTSSSSSFPDLTRAASELLAATLTHTPSEFLSPALRAEVDRTLILTSDKNAMLASVLNPFPAMQGRGVGTSILPFLARSHPAETEVECLIRPRMPVVMTGLTANGYVPMEDDDDEDEDEAITAVPASTSTGFLKPTPTPTLQHDDMMDVEKDIPSPPSKRSYADEVEQPAAPTIATTSPSSQSKKPRFEPKAAAVTQPPLDAASPATFTGTAAISVPTSSIAGPAPVQTPKPAQSSIAKPSALAAAAAADDESDDEMPSLNVDPDTEDEDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1Q5</accession>
    <name>A0A8G1R1Q5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4140 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_459176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515880.1">
        <property type="nucleotide sequence ID" value="XM_025661634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1Q5"/>
    <dbReference type="GeneID" id="37165036"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025554">
        <property type="entry name" value="DUF4140"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005:SF8">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13600">
        <property type="entry name" value="DUF4140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4140" evidence="2">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="316" mass="34997" checksum="C887989424641AF6" modified="2022-01-19" version="1">MKGSAHQEFSVEDLPTKSVSFHPTLATITREFPVRVQPGTFAITINKIDHQVDPESIRVESLGPARVIDIQHANVLRYSSTCKPISDRSVFDPVRDPDNRKDTICKPSEGLYAGCGILKAYSRNESLSRERQPMGYDGAGAQDPYRGEYGPALYEGANPSKLEEQNQRPAPEKPALDHYCQVVVHLEGQVTTPAPTSSPGTLPGDEENQAGGKTQSNEVMLHLIYTVPAKSELKLHDLNINTLFSTAKIKLCALFTNMSSETWRDAQEELESSMYHDFYPPDSKVPESISQGHGLSVSYELPGRRVIKPSSAPRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1V8</accession>
    <name>A0A8G1R1V8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_478535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514651.1">
        <property type="nucleotide sequence ID" value="XM_025662904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1V8"/>
    <dbReference type="GeneID" id="37166306"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH56729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="464" mass="52432" checksum="2405C451F24F988A" modified="2022-01-19" version="1">MPWQQISPGHYERPFDSMENFYRAVADAGAPLNKQHFLISCTLKLKSFPQVQNLQQARKALRQRYPQIAARANEDGSRLCYTVPSPEALDTWVQETFIIRNGVSADEIYSQEPPSSQFFLFCLPDTRELLFRTPHWRIDAYGLMYLQDTFLKILANGPRGHIIQLDGTEVRNLAPALDEAAGVPSIITPAISQAADEEISVLLHNQPTISIKTLPNALPATTRRLKSALPASTTRQIIKSCKSRGLTVTAAVHAALIVATLPYVMDLHHSKTSTTTTDGERKNYTTITPFDLRKYLPAPLNGPDAATSVYHTAIFMSIDLAVNKDFESIAAETRKAYGRDLSKDDPRNLFNFLPEYVNKALQLLSQQPDDPLRAPAHPDLSSLGIVNEYISTKYHGEEFTVEVEDWWLALESIVRLLLIHVWTWDDELVFSFNWNDAFYEEGFIKRFLSEWMEVLCESLGVSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R217</accession>
    <name>A0A8G1R217_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_450213</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514741.1">
        <property type="nucleotide sequence ID" value="XM_025660325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R217"/>
    <dbReference type="GeneID" id="37163727"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000029">
        <property type="entry name" value="4-aminobutyrate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH56819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="498" mass="55720" checksum="106F3E497265D52A" modified="2022-01-19" version="1">MAAVFRSSLRLRPTTRLSAVRTLTTTPHMRAAEKPYFPDEPSAPKLATAIPGPNNKAAAEKLDKVFDVRSLNMLTDYYKSNGNYIADLDGNVLLDVYAQIASIPVGYNNPHLRKVAESPEMVNALINRPALGNFPSHDWADILNTGILKAAPKGLNQVFTALAGSDANETAYKAAFMYYRQRERGSAETEFTEEELETTMKNQSPGSPQLSIMSFRSAFHGRLFGSLSTTRSKPIHKLDIPAFDWPQAPFPSLKYPLEEHAQENAQEEQRCLQETERLIKEWHNPVAAVVVEPIQSEGGDNHASPAFFRGLREITKRNNVLFIVDEVQTGVGATGKFWAHDHWNLETPPDMVTFSKKAQTAGYYYGNPALRPNKPYRQFNTWMGDPARALIFRGIIEEIERLNLVENTAATGDYLFSGLERLAKQYPEHLQNLRGKGQGTFIAWDTPKRDEFLVKAKGVGVNIGGSGQSAVRLRPMLVFQKHHADILLESVEKIIKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2F9</accession>
    <name>A0A8G1R2F9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kynurenine aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_372728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515204.1">
        <property type="nucleotide sequence ID" value="XM_025656053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2F9"/>
    <dbReference type="GeneID" id="37159455"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="81"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH57282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="469" mass="52407" checksum="E8532E4FCD234162" modified="2022-01-19" version="1">MFSGHRAAIFSTRAIKFQPSPAVFLRPSSTPTLPRQSLFRAMSATTARPDPFKPAARVAGQRQDVWSIVNEAAAASPVQPIVNMGQGFFGYNPPKFALDAAKEALDRVDCNQYSPTKGRPRLKKAIADAYSPSFGRALNPDTEVTITTGANEGMLSAFMGFIEPGDEVIIFEPFFDQYISNIEMPGGKIRYVPLHPPKDGATRTSPASEWTIDFEELENTINDKTKMIVLNSPHNPVGKVFSRAELERIGEICVKHNLIILSDEVYDRLYYVPFTRIATLSPELYERTLTVGSAGKAFYATGWRVGYLIGPEHLIKYVAGAHTRICYSSVSPLQEAAAVAFEQADKVGFWDESRAEMKKKMERFCEVFDELKIPYSDPEGGYFVLANMSSVKLPEDYPFPPHVASRPRDFKLCWFLIHEVGVAAIPPTEFYTDANAHIAEDYLRFAVCKNDDVLETAKERLRGLKKYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2I2</accession>
    <name>A0A8G1R2I2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Meiotic nuclear division protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_449078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515899.1">
        <property type="nucleotide sequence ID" value="XM_025660084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2I2"/>
    <dbReference type="GeneID" id="37163486"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1 HTH" evidence="2">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="200" mass="23561" checksum="D6B29A548F642316" modified="2022-01-19" version="1">MIPSVASINGIQVKEYVQELADERRIRVEKIGSGNWYWCFGGEEKKEREERIRRLRREVDRVRGNWEDAEARLSARKQARVQEEAEEAHGDGNGNGNGEEERRRLMEQKAVLERETHQLQGEWMALATSSEGKSLPQIKEETEEYRRLAHQWTDNIYILEGYVDKVTGGDREVLRMVQRECYKEEYVEGEGLRELEMEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3A0</accession>
    <name>A0A8G1R3A0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein Zds1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_301372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515386.1">
        <property type="nucleotide sequence ID" value="XM_025655348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3A0"/>
    <dbReference type="GeneID" id="37158750"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Zds1 C-terminal" evidence="2">
        <location>
            <begin position="719"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="894" mass="98597" checksum="A8FDB852124E3883" modified="2022-01-19" version="1">MQASPSPSEPSGGYATKRGHVPQLSISDPSHHVTEAIGHMYDDDYDKRDSRRLSFISSPLSESITIIPTKLAGSESPTSPQSLQVQNHINDHNNRQANGQPWPHGAKSAESSPTSPASTTSPVSTDTATTSFPLNDVDYESDPAAVAQELNNLAAIRRMSMDVAATDDPDLPSFSVPSIAPSPSDDENDASRLFWVPARLHPELAPKEFKSFLESKTEQIKRKSGDFSTLGPEREGSIGGLRRKRSMLSRQIDTSQGYTDGAERLERKRSQSKRDSLGPNLHELETIVNDSKPRVPNATNILDGIQKLGISTDEDKPILPPAPPSHSLRRSTRTQYRKAGSLKKGEKAPYSKRVARTSDADERVTSPTGSSGGQAVLGLTRMSTDPTPSSTRAQAAAKSTIGAPQAPVVTTSATTASPSVDSAVEQSQPANDRSHDAASSDPSNRASAPAHSRQWHSRISSNGRSTADVPPSEQKIPEIIETPPPGTPTTPSTPTSQSHASPKAPAGQDRMQERSSSKRSAHSRTQKETTPTFNDFANTPQPLPGNTTRTDSLSYIPTFEDRKAESKEKEKETKESKKSKDKKDSEGGRKSSWHWLLGSEDKDKEKKKDKDSDSKKLKAKIVDKVHETAHALPSSSDSSQRGRENVAVDRLDPKLEEERRKDNARRTSGESKKEKESGLFSSIFGGSRKKSSGDSSHHSHHHKKSASRNLSPDPPVRELRPDVDYAWTRFSILEERAIYRMAHIKLANPRRALYSQVLLSNFMYSYLAKVQQMHPHMMLATSAAQRQQQKQQEEYQQYQRYQEVSIPRRCSIVIEGSNCSSKLQSQEQQYTDSSYDDPQMYEYTDDAQDHYGAHSQSSKGGYENGNAYGPGHYQYGHSTFGDDVQLDDDDDDMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3Z3</accession>
    <name>A0A8G1R3Z3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Anucleate primary sterigmata</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_420894</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516153.1">
        <property type="nucleotide sequence ID" value="XM_025657908.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37161310"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024545">
        <property type="entry name" value="Mto1-like_Mto2p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF63">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12808">
        <property type="entry name" value="Mto2_bdg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="564"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Mto1-like Mto2p-binding" evidence="6">
        <location>
            <begin position="1377"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="domain" description="Mto1-like Mto2p-binding" evidence="6">
        <location>
            <begin position="1533"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="222"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="429"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="778"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="846"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1441"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1577"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="721"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="459"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="872"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1484"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1496"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1577"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1594"/>
            <end position="1606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH58231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1637" mass="183277" checksum="BB7E960236C4B225" modified="2022-01-19" version="1">MSTASPQPPSSPSPESPNVAEHAQPVRSSTFSPPPNPLHEEGLPALEDVFRDPTPLMVAENARGGLSPTTMDTPARDGAVDDHYAHEEPGALSDAQRHNSAVDPSTVEDPAHDDSNLSLPPLPDNDDSSLLLSADDDYQERVDDQTFIKEKEMRRQLMDMESSFLPEPSTIEVATTNRMIGADDTYLVGIHEEEPVPEVLENTQISFVPPDDSIHDIAAAADGTHTPQTPTPEHRPDTAEDLDATPAASPEQHGDNTTILEAIPSSPSAAAAARTSTRNRSTSSENAPDTSQIARDDAFDRSPVPDADISLQSSHHKIRSLSRSVSPGTSRLFQDNSANDADTASHTSSRRSNRPKYLTSRSSAHRLSYSSVTSAGTEITNSDATLGADYALQSGGAAPGNPGLAHAGQRNTLARSVSLGSMASGISGYSDENLFDRKNPGGTTEGGLQTLDEEEGPTQSRPGSSYQRYQQQQQQQQQQQQQQSEQRPQQDFHPDDASGPMTPRAKPQDTGFPTDTVLAERVKDVQVPSAFVKQFREDYGSRGLSPEKRTSATPAFARSGRTMTLKEQSSTIDRLSKENFDLKMRIHFLNEALNRRSEEGIKEMISENVELKSDKLKLQKDNQSLKRKLRDLEKQLKDQQSDKESMLNHDPEGSDEEDRDPAQDEEILFLRERAETYELEIERLRSESIARESEKRRLAEMVKSLSDGRPMGSDVGAREERDMWKDMLEAETAAREQAEEENKRLREETLRLKNEMNFPVVAARVGQRDRIGSMASYSAASERDFSRDPHTVSSSSSTLVMELELLKQENAELRKEVSAQTSMLTSRNREKERLYQEIEELKLGQRRDGTRSVAGDSIFDRSASRAHGRPSSRASDGTGQSPSDDAEREDLETRVGQLRDQVSALKLENQSIREQLDEVNQDYDSLDKAYQADIAEERDEAFQNIRAEAQEELDAMSEALEQKVEECQRLSEEVRVQDENLRALQAEMRSASEGIIRLEEDAQNNLQRYKAVQQELEDCNREMESLEKDLYEANTKVQRLTVQIESSQNEIAFLREEQDGDKIKIGDLESELKSYQLSLQSERDKTRELEERLAEERHQREVVGSKEKQEVQRIVNELNREATSAKEENRKLRKNLSAQEIEAATWKERLLDLENNLRETLGDLTGSRSSLISNIMKLQKELESTALELESTRAKLDDKESLLRNRDALLESHGLESRKLAELLDRERHARRADKQSFEQALKSHHQASRTITQNNSRISELENARNQDRKRFTTLEQQFRDQLSERNVMLLNIWKRLSAMCGPDWAHSNSLINGNLPSQEVIGNILFWPGFSRNLLLAVKTVESVISGFKSRIKGVERDLTKQYQMLEHTFSLRVKKLDRLEESMMNMRAQQHSRNQSGMSPEMAKLRGENRLLKAELNLLQSHSRSRGPASAAVSAAAVGIGSNSPRSPTRALSLDPGADAEPGSLIRHHSAVEKPAPSRGLSRSATTGIPQPSHSASTTSTATLANDGPGALVQGSRSRHMSADPGSNEKWIQRLHELEKRLKAEREARLLDRSGARRRLEERDAENQRLRAQLERQHVRKELSAGTSTDEDVRARGQRRLEGSDPGTSDGYDRRRDDEMSSSEGEGIYVDIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R411</accession>
    <name>A0A8G1R411_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cap binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_459077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515776.1">
        <property type="nucleotide sequence ID" value="XM_025661627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R411"/>
    <dbReference type="GeneID" id="37165029"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000079">
        <property type="entry name" value="Related to cap binding protein 80 (Cbp80)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000035">
        <property type="entry name" value="snRNA cap binding complex subunit (Gcr3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000045">
        <property type="entry name" value="snRNA cap binding complex subunit (Gcr3), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G-like type 1" evidence="2">
        <location>
            <begin position="335"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G-like type 2" evidence="3">
        <location>
            <begin position="542"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH57854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="843" mass="94062" checksum="91525E061FAA969C" modified="2022-01-19" version="1">MADYERRPHGPRGGGQDDDYDRRQRRRYEEPLIVKVRRQLLTIAESAARRAEDDAVSIAKSVADNYEDQEFRNSFVDIALDLVLEQPLKIPFVAATVLIANFQKSELVSDVLSRSGVCLQKYIDAGAWREVKLLLRFLGCLQCVFEGDGIFPVLEELFARAVDLQTASSEDLIGLELVKIILFTIPYIMASPAAGFESQATALLEKTDIIASTPHTLVDLVNPFGLENGKPIATPSVISLLQNQLQKESGRGWELACLPRPWRGALEALNAQEPEEAQEGQESQENGAEPKTYENEPKHAFPQITVPSPVKNGTRAIFPEAYLSVYANQDMETVPPTSDIASSLMRDALVDTINILDFNRIATAKFLIDVDCYFTPHTFVKRATPFDRLRDLPGDINLWKPEDVAVDAVFSQLFQLPSPEHKLVYYHSVLTECCKIAPAAIAPSLGRAIRFLYRSLETMDLDLSHRFLDWFSHHLSNFGFTWKWSEWIDDLELPLVHPRMAFINGALDKEIRLSFAQRIRGTLPDPYQDLITEGKEKDTPDFKYSSDTTPYANEGREIMQLVRKKASDEEIQPFINAIEEQARSLGVEDPLLPSTDAFVTAICFVGSKSLSHVLSCIERNKERLLAIGPQSAQARRQIITSVMEYWVDQPGVGINIIDKLLNYTILTPLSVIEWALVDKLEAGTVLAKSHIFEMISATVGKVTNRLRQIVAARTQPGLYEPQLSVLDETLSREKVDMQSLFKVIEDSIVSVAGGSNDEQMERGDGSGNLPEDEIIRQWGQRWLRVFRRKAGVEESFIADAMATATPVGTVAPPPAPEETGASESIPADGEMDIAEADASVDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R416</accession>
    <name>A0A8G1R416_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_457785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517618.1">
        <property type="nucleotide sequence ID" value="XM_025661542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R416"/>
    <dbReference type="GeneID" id="37164944"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="32530" checksum="60E1F14012BC0706" modified="2022-01-19" version="1">MGEKKEQHFVLWLDAANILRYQGILGNILVGDGHSAQVFNIRVLNPESNTETFQGTRDLVAKVYDPLYLDDHGGYLNPFLCVDKHYTHEAQTYRVLSDLQGDLIPRFYESYSTDINCQDIGDDAETSEMCSRTVRLILIEHIPGKSMLQAGPSNFPQRDRQQIMKSVIEFESEVYRRDILLTDLSPRNVMMVPPGSRRQCNLVFLDFAGALFRRKLDEPLLASREFFLGQYISPILRWKKGMKLEFDDWIDWEWADWVDAEFAHTAHTITPAMRERYSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4T1</accession>
    <name>A0A8G1R4T1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spindle pole body-associated protein cut12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_399149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514737.1">
        <property type="nucleotide sequence ID" value="XM_025657086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4T1"/>
    <dbReference type="GeneID" id="37160488"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021589">
        <property type="entry name" value="Cut12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF9">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11500">
        <property type="entry name" value="Cut12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle pole body-associated protein cut12" evidence="4">
        <location>
            <begin position="173"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="457"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="502"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="597"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="623"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH56815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="759" mass="85541" checksum="CD204154FE39C390" modified="2022-01-19" version="1">MLGWITGQEDQVADNSRAGEPPETPAPVFAIRAFKSALFGTPGADDDESTHRTTTAAAATTSAALKTKNPSTNQLLNDHITLKPSSGNTGDAFKASKADLDLAVNAMASPTKSILVTPGTASNRRKTVSFGDGVVDNERKREDPFTKPNKTPTSSSNNFSSQWSANSSDGKFKPRSKLTQALMDSREKSKGTGLFSSQDLEPNPSSEGSRPSPTEDDNDDTINLNEPRSQSGKYWKAEFDSYRTKTTWEIKKLIQYRSAAKTYAKKKDEEASRLADKLREEEIKVSEMERHVTHLASTMVGESANADKEKLVQDLTKQTALALQYKHRVNSLRKLLERHGVVGNEVDDIAEQSESESSSEKATEELRKTQQALDEAKTKIDDMKLQQSDFTKLQDLARSSEQKACELQKENASLKQTLARVKQEMSKYEGRRKEKEAKLKQREAKLETRIQEYRERLKTASQQHRDHEEDLKESFNEERRRMQEQIDQLKIKLTAIESLPHTQVRARHTESPRKNYTGVHVFDFGQNSPQKDPEDDNTADIDEPPSPSPRAKERRSYPSRYTTTAGDLDLKRAMKAMGITDEDQLAYLGESLKPPKARYQNEHHDDEEPATIPPSSPPDYPHNHHHHHPPPSTRPRPKQKSTNTNTYRSLYAPTNTTMTSLAHHLANNLDDSHHGRPRARRSPSKYSLDAVTALPDSHVLDRAKRRQSLAAVVPRDSIPMDRKLQAQARLKQRKEETRKGKENMRTYTNQALSVLEPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4T3</accession>
    <name>A0A8G1R4T3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF726-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_393151</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517485.1">
        <property type="nucleotide sequence ID" value="XM_025656874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4T3"/>
    <dbReference type="GeneID" id="37160276"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049545">
        <property type="entry name" value="Gta3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF22">
        <property type="entry name" value="DUF726 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20978">
        <property type="entry name" value="Gta3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl-tRNA amidotransferase complex subunit Gta3" evidence="8">
        <location>
            <begin position="59"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="234"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="801"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="801"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="837"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH59563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="881" mass="96715" checksum="B9A1E86AAC6BF6B0" modified="2022-01-19" version="1">MFLRAALPRLSALIGRQPLRCSTARRMYSASQSGDADIDAMLAKPTWSVRSLLPEESDKPSAPSVTPAQLRHLLRLSALPQPATEEEEKKMLETLESQIHFVKQVQRIDASGVEPLQSIRDESPEAVQENTIGLEKLREALSKERVRRRKASQNNPFWNVTLWPSAHMWKSFKEKHASKFGSGPSPSPAPPKSDRDQDLTTILDRPQRADLTVLVAEITQHMRDAIVQNFHWPISKENDPSRDQAAHEQDKDTDPLSVQSDGQSEETTAVTTTTQSEYKPTAQDLKSEAKSLTSFDDWRDSVLLRIGEVVNRDEESEEDLSESDPPQQLHEPEIDEDQGSLQKQREVYRPVETPLTQLPKAKRLLILHSLLLLMLSLEHYNARSRVLMLYVASSLNLDVTILNGDESKVARGLLDTALQLANAEEGREKKRDSSRKWKVGIASVAGAALIGITGGLAAPLVAAGLGTVLGGLGLGATAAAGYLGALAGSGVIVGGLFGAYGGRMTGRMVDKYAREVDDFAFLPIRGSRQRSEDEREAAQNDHMLRVTIGITGWVTEEDNFVVPWRVIGADSEVFGLRWETEPLMKLGNAMNLLVTSAAWAAGGQVLSRTIFAQIMSAVMLPLGLLKVARVADNPFSIAKARADKAGEVLADALISKVQGERAVTLIGYSMGSRVIFSCLQSLAKRGAYDLVESAILMGSPTPSNAPHWRRLRSVVSGRLINVYSENDAVLALLYRTSSLQLGVAGLQPVQDVPGVENLDVSETVSGHLRYQFLIGRILGLVGLQSVDAQEVAREEAALAVKDKKQEQERIQNERRAGVKGDESAQRVLDNGDGTEEEAMHAEVEEETRDRLSRMEVSEGSEDQPARSEFKIKRRPLPSEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R542</accession>
    <name>A0A8G1R542_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_510746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517665.1">
        <property type="nucleotide sequence ID" value="XM_025664565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R542"/>
    <dbReference type="GeneID" id="37167967"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="111" mass="12464" checksum="FAE714F9E4A02CCD" modified="2022-01-19" version="1">MVQSTYSPVLGTNLRCALRPSPKSRDFVRSLAPFRPATTVERISQMYALSSMLSKALDDLPMSVGTGMLCLLSALVWVRFLGSEPGKLPQDSRKCSPKYYKYYHVLPDMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R562</accession>
    <name>A0A8G1R562_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Paf1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_417224</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517695.1">
        <property type="nucleotide sequence ID" value="XM_025657767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R562"/>
    <dbReference type="GeneID" id="37161169"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188:SF12">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="444"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH59773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="503" mass="56132" checksum="A587DE5C94C3357C" modified="2022-01-19" version="1">MSKSKDSGSSGGFHQEYIASLRYRNDLPPPDMPPKFLDIPHEGLDRFLTPGFASNLARREEPNIDVDAEGGMPIDLVGIPGLHLGDESAIMAPENPEPIDQADLALLMTPEQLKNPAPKNTNVSFLRRTQYISAGLRAPDGPKVAPIRTKRGMDKTKSQDDPTYIKKYLQKGFDIAYPHSKHVGEDTASKIKGHTPTKLEHDAWAHPVHPDNPKLKPVGFYPLLPDLEGFPDPGGFVQFKFDKAPVQDVSGKRDKRMDVAILLPSAPEERVCQEHNTKAALYKTNPNLYPDPGPIPWDYDLYLPEKKDAAKNVSASLRITNPDRDNEALYTHDGADNTKFHRFDRVRTYATSAQTLGNDQKQKDIALTLFDPEEVKDGKRDGLDSRQRAAYYYPILGKTRLKPERARTIAQAGLAPTRPKTKEDQVDQIQVVVRDPDEAEVYKRSLHRAAIDPKFAESMPPPPENPENDAEPAKQEEDEGEHDVDRQASPEDAHDDAGNDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5T9</accession>
    <name>A0A8G1R5T9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_446668</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518010.1">
        <property type="nucleotide sequence ID" value="XM_025659552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5T9"/>
    <dbReference type="GeneID" id="37162954"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF5">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH60088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="141" mass="16294" checksum="162A530A8120E39A" modified="2022-01-19" version="1">MSSTTPQPDSTTTKPKYNLRNPLPLSAAQEAEVKQLYYKRVRSLCAPEIKAFAECAVNRTITATWVCRDQRLAMNSCMVAHAKPEVEDRAREEWFATHEERRKAKEEELAKVERRREEVIRMMREDQERQAAAAKAAAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R600</accession>
    <name>A0A8G1R600_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="1">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_368052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="1"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517835.1">
        <property type="nucleotide sequence ID" value="XM_025655847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R600"/>
    <dbReference type="GeneID" id="37159249"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF10">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 63 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="3">
        <location>
            <begin position="446"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="3">
        <location>
            <begin position="719"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="933"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH59913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1027" mass="120061" checksum="99F7B73BDA2BADF7" modified="2022-01-19" version="1">MVLIDKHEYVSQEERRLREDREHSRYWKRWGPYVAERQWATVREDYSENGDAWSYFSHDHARSRTFRWGEDGIAGVSDTHNLQNIAFAFWNEKDDFLKERLFGLSNPQGNHGESIKEAHFHVDNTPTHSYMKYLYKYPQKKFPYKELVEENGKRSRQDREYQILDTGIFDDNRYWDIFIETAKEEDDEEELLFRIIAYNRGPEPAPLHIIPHVWFRNTWSWGYEDQKEKPSVEKVHPMIAKTSHHKLGERYVQFAPSPPVGDGQDDVFPQMMFTENETNNELLWNTKNSQPYVKDAFHRLIVNGEKDTVNPANKGTKFGAWYAFNEGEGIPPGECAVVRFKFSRKRGTFLDEEVLDNVIDERRAEADDFYYHISPLPMSDDLRNIQRQAFSGMLWNKQFYHFVWDQWSNGDPGLIPPPPGRKHVRNQQWKHLYMDDILSMPDSWEYPFFCAWDTAFHCIPLAMIDPDFAKKQLDLLTREWYMHPNGQLSAYEWNFGDVNPPVHAWATFRTFKIERKMYGRQDLDFLERVFQKLLLNFTWWVNRKDSEGKNVFEGGFLGLDNIGLFNRSEPLPTGGVLEQADSTGWMAFYCLCMLNIALELAKHRRIYEDIASKFFEHFILISDAMTFKSGGQETSLWNEDDGFYYDAISYGDPWTQQLPVRSLVGLIPLYAVLTLEPELINKFPSFKKRLEWFVENRQDVAERNIASMKHRGKDERLLLSLVSKSRLEQILKRMLDETEFLSEHGIRSMSKHHEEHPYSMEVNGQMFRVSYVPGESDSALFGGNSNWRGPVWLCVNFLLVESLLRFYMFYGDSFKVECPTGSGEYMHLGHVAEEIQHRLQHLFARNDEGRRAVYNGSDLLDFDEHWKDYMWFHEYFDGDTGRGLGASHQCGWTGLIAKIIHDTGINCRVPQTPRSPFAAASHYFDDIFSRTVRPRGSRRPSVRRSSTSRSIGNRSDFESAFTGRSTPGPESALDDDEKLGESGLGFGDDEHVSQYVESQLERVRSRASMGAYEDEFEAQADRVPNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R637</accession>
    <name>A0A8G1R637_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_221422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518126.1">
        <property type="nucleotide sequence ID" value="XM_025654702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R637"/>
    <dbReference type="GeneID" id="37158104"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH60204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="404" mass="44524" checksum="9F033480B318FC32" modified="2022-01-19" version="1">MFGAFRCNNSTSKNLEFIALSRKVGMDSRNSAVLACEPCRAQKLKCNGDLYGCERCQESSTDCTYRTPTPASSTPLSLKHSNSDLPALPLKRRRTNGVGALRIHCPSPVGPTPRIQSPLVRPEPVLVNSYQDWGQFCNMNTTEHPGLNLTLEDNLPCYPTAPLISEAHLKPSHLVSPATSYSSGVGPSVFVRNPHTPVTSQDPSKNQGQSCKCIQSLADTLERVGGDNDQRSNIDHSERLDYLLTSLHTGVDTCTRVLDCGSCDICATNSMIFMALIQQLAIRSRDLCDLLLSLQDKPQRTLPDDPADLQPEASVFIGRYQIQIEAVCRELVHTLANIHFRDLRRLLARLPDLIGTKPRANKMLTEATETSEKASHILEGILVKRAAEKAKNHELYGLITERGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6L8</accession>
    <name>A0A8G1R6L8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_243307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517379.1">
        <property type="nucleotide sequence ID" value="XM_025654861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6L8"/>
    <dbReference type="GeneID" id="37158263"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="39"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH59457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="354" mass="38237" checksum="1EB183B7F46862D7" modified="2022-01-19" version="1">MASTSTPELTPEFLAQDRRPEARIGIGVVTALSGAVVLIRVYARWFMIRSFGWDDGLICMAMLLNIAVMALTTQVLRYGAGLHVWALDTAKTPLLYKWLVSAQLVYMIALWVCRLSGLAFYRRLNPMPQFQLYLRISFAFVTAVMLAQVLIIALQCVPLAALWGGATGKCLGSKTVFISTAAMTIICDSLILLLPVKIVLSIKANATRKVALSVVLCFGVFAVMTSVARIISMIPAIQKTDATWYFSVVMVWSDTEVSTAIIALSLPALKGLVGAVAGSTRKGTDQTPGSNGGPDLHLQNVPAKGDQHLYEGSDTYPNEARASIGDNASQEALWVNTNAGIHVKNSVRVSVSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R752</accession>
    <name>A0A8G1R752_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor NosA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_487808</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515907.1">
        <property type="nucleotide sequence ID" value="XM_025663481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R752"/>
    <dbReference type="GeneID" id="37166883"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF50">
        <property type="entry name" value="NOSA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="630"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="630"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH57985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="701" mass="78082" checksum="F3EE1DE9BEC0DB68" modified="2022-01-19" version="1">MPAAAKKRSTPVRISPVKSEECSQSPSASEGTSTGSTDKNQLKLHKRSRSGCFTCRLRRKKCDEKHPSCGACVNLCVKCEYKRPIWWGNAEQRRIQKERIKNKIKQTKMHERNGALTDSAARTRSMAVPSPTSPEYEFGRPAFPEQYDIFASHLPTPAMNQPIYAPTHPYEIDVKTERHTFVNDVPLRHDSCSSTFSTFAPPQLNAPLPTFPSEDWFHDEYFAQVPALPGIDPALCEQSIGQTYAMLQSNIPVSDHDRPLLDHFIHNVLRIIFPVLEAHQRGHLRAQAILQALETNKCYLHCCLSVAAIHLKTTEGLVGEQIDHDIMRNRFEAVSQLCLALGEDTNHEEILDATLAMIFFHCSVGPADDYLPDIPWFEHFQAASNLVHRLGLPTAVPACGNPYMLPPFTMTLASWIDILGSTMHGKTPEFAHTYRAKHLSGSSLGLRELMGCDDRVMYLISEITCLDALKRDGRIDEMGVCSHVSALGQQLEFTEPVNQTLESPFLPNGAFSPEILTKNITAAFRLAARIYLCSLVPGFDRNQPSTVNLVAAVANVLYVIPSGPEGFDRSLVWPILIAGAYSAPDSHFRTVLADRAAALGEHAELGSFGRMYRVLKEVWRVSDESIEPIEPVETVEPVESASAPEERRSSSASSCSDAPVKAEGSESPKESLVPWGAKEMKKPFLHWREIMQQNGWDYLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7L3</accession>
    <name>A0A8G1R7L3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_364912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518705.1">
        <property type="nucleotide sequence ID" value="XM_025655718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7L3"/>
    <dbReference type="GeneID" id="37159120"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="97" mass="10839" checksum="D61D73A5EF3D317F" modified="2022-01-19" version="1">MAGTAKPPSSAEVQNALARARDSESGPDAATMAILDGSVKGLWERIKAEPEYVLNQKEFALFNYFILRYKKEPACKRAVEQFWNHYRADEATNGSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7R2</accession>
    <name>A0A8G1R7R2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">14-3-3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_446239</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518996.1">
        <property type="nucleotide sequence ID" value="XM_025659461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7R2"/>
    <dbReference type="GeneID" id="37162863"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="3">
        <location>
            <begin position="204"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH61074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="360" mass="39125" checksum="40CE43FC67C58674" modified="2022-01-19" version="1">MASSEVDQKALGNFAAMTGLENPFLSATLYKILGLSVMLSKKLLRARRLRRLDPTRETKSLHLYYHIIWLSREGLLILEEFVLPLVEGCMELKILAYKLRASFYHIFVLFQNQPAVHTPGIVSLPSSTPLFNGVTEAESPSKDSNSRYSFQLKPDTITVSGKPSSASDSAPRGKVTQAPPGFAPVQPPKSTSSFLLPALDYTPTATACFNHAALLADQFLPGSHPLRLSIKLEFAAYLYDCLHDAHACRRLAKQAIADVYNAQEGMDDESFEDAAEIVGILGKMVKRGRNASSAGNSTTALKTPREERSEGTRTPSSQTTSKKPAARVPKSSSSPARATKPTTSEGMSPAVPDPTMMNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R868</accession>
    <name>A0A8G1R868_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_119648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519793.1">
        <property type="nucleotide sequence ID" value="XM_025653900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R868"/>
    <dbReference type="GeneID" id="37157302"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034516116" evidence="3">
        <location>
            <begin position="22"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="86"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH61871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="282" mass="29013" checksum="53FFDEBB5092196D" modified="2022-01-19" version="1">MAPLSKSLALAGTLFAAFGSAAPVEKRSTEVVYQTVTSVVWTTVDVTTTIYGAAPTESAAASPTPDSQYQVPGNSQPEQSVNYQPSSFTTSTSTAWGAAWTPEPASSTTSTSTSEWEPAWTPAPTSSSSTSEWEPAWTPSTTSQEPAWTPSTTTVPAAATTSASSSSGSSGSSGSSSGYSGSCSSGSPCTGDLTYYVAGLGSCGITSNGNTDMVVALPHGIMQDSDCGKTVKITYNGVTDYGTVWDKCMGCDNVSIDLSEKLFKKFGTESEGRLTGAEWSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8A8</accession>
    <name>A0A8G1R8A8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_415075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517996.1">
        <property type="nucleotide sequence ID" value="XM_025657672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8A8"/>
    <dbReference type="GeneID" id="37161074"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH60074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="700" mass="78325" checksum="A99E8DAD95E5C2BE" modified="2022-01-19" version="1">MKRKNDAVPEAMVQRWSRPPLSCRFCRAKKLRCDRTQPCSNCVLRKVPCEYTGQGPSDSSDELRGAHLSGNQPTAATVSIQQQQPAPTIPPTYSQNTTAADTNDILNRVARLEEAVFDRIHIPRGERIADLYDCMRDTKSISRCLPPWTQARQLLDHFNVVIQPTFGVFHIPSTKELLDETYRGILEGEEPSLTVLVLFFSIFAGAVLVATPELLQLLSATEAEAKAAFATYARLALCIIDNPIQPVPPSTTALGAISALSRVLFHADWYSHKAQALRIDAICMARSMQIHLLDTIQKQDERKRSKYDAIEVEVQRRAWWHLVSNDWITAFSQSPQEGTYLIHPKQMKVNHPSNIDDESLTPTGPAYSFPLSVPTSMSVFIFRIHYADLCREIIDTLGMTLLESSQPDYKTLLNIDHKFHTFVQSLPTFLQNDPASIQESQEITQQRPYLAWQRTVAHLSFHVRLCRLHRPYHREGLTNPKYAYSRLTCIRSAQTVLDLRRSLKDTGVLAGFNPSDYSLVMNHVFFAAMVLATDVSMKPTAPGADTRKQEVLDVIHALEKSQNESASLMEAIRKNTQTLLSILQESQREVQQQAGSPVRTDSIAVASGSGGAMSSAAPSRSRPVGVDENMTNAAASGHLPLSDSMPGLGHEDEDPMWSGARRNSWGQLWSDLFNVAPEMDGLQWDLLLNDSDLPFQSEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8G6</accession>
    <name>A0A8G1R8G6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor IIIc-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_188065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519034.1">
        <property type="nucleotide sequence ID" value="XM_025654406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8G6"/>
    <dbReference type="GeneID" id="37157808"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025451">
        <property type="entry name" value="DUF4211"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4211" evidence="2">
        <location>
            <begin position="302"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="564" mass="64035" checksum="5F690455FA6B0379" modified="2022-01-19" version="1">MPRTYGKKKQTRLAFAPLSSPPTKKEDSDKEDDRRANLRYAHPSMPFIRRGRSQKDAKSPPQRTPEPKAEPVSDSDSDIEIVRSTRKNPQRGSLKRKRTDVSSSESPSATPQKPAADSESDADEVVPASRRKLRRGVAPQPAIAADDSDSEEELVISPKKRRTRNASPDVPQTPRRGLEQDELDIEEDLQALQDSVVKDTRTRGRLANSARAQRQQHLEALRRRRAGKTASDTEESKSDIEKSESGDGDSDGDGDNGSEQEDEPEAHEESPKRKPQFRTRLEESDVESAIASNDDLDRYEDDFVLEDDDDTLGAPTGLEDIPIEFSRHAYKQLKDYFQDAVEWMVHNQLNPAFPRSDPVYEVAFSKLEDEVKGRTGSQLVSSVWNAKFRRALLARPQIEITTFPTIENHPCDACNRSGHPASFDIKVYGKAYSLKTLEPLTDDDSDDDDKEDDNDHEERDRGGHILPDENTRFFLGRHCKNKATLAHTLTHWRFHLNEWVTGYLEHQGYLSETRVVERSHWSTKKKTKYAVKAVESMIANGEVKKLWRDFHINLRTARETTTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8J0</accession>
    <name>A0A8G1R8J0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_466777</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518116.1">
        <property type="nucleotide sequence ID" value="XM_025662148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8J0"/>
    <dbReference type="GeneID" id="37165550"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF29">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="95"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH60194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="555" mass="63420" checksum="B3C1B696BF2E26CF" modified="2022-01-19" version="1">MASRKDVSQETANHFDQRHYSDSSQDLPSPKDKAQVHTRPYEDATDATLDNNPFADPEVAERYALIYEKAQYECRHVFDPTLTWTAEEEKALVRKLDWRCVMFFGLQVDRGNLVQAVSDNLLDDLGLSTNDYNTGNTIFLVAFLLAELPSQLVSKQIGPDRWIPMQMTIWSIVAAAQAALSGKKSFYATRALLGILEGGFIPDIVLWLSYFYTSRELPTRLSIFWTALSLTTIITSFLAFGILHMRGVQGMAGWRWLFLIEGLITLLIGLSSFFRMPASAVDTKKWFRPKGWFTDREVSIVVNRVLRDDPSKGDMHNRQAITPRRLWNSLRDYDIWPIYLLGLIVYIPQTPMTSYITLILKGVGFGTFTTNLLTIPYSVGHIICLLLLTRLSDWLKERSLVSMIQSIWTLPCVIALRFWPGTMTNAWGTYATVTVLLCYPYCHAILVGWCSKNSNNVGTRTISAALYNMCVQLGAIIGNNIYRADDKPKYHRGNSTLIGINILAILLFIGTKIYYIYRNKHRERVWNAMTEEERQDYLQNTTDTGSKRLDFRFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R923</accession>
    <name>A0A8G1R923_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc finger C2H2 LYAR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_434944</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UPF0743 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520258.1">
        <property type="nucleotide sequence ID" value="XM_025658492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R923"/>
    <dbReference type="GeneID" id="37161894"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="cell growth-regulating nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51804">
        <property type="entry name" value="ZF_C2HC_LYAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C2H2 LYAR-type" evidence="10">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="66"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="207"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
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            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
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            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
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        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH62336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="524" mass="58492" checksum="0D08CD6EB6EDCC1D" modified="2022-01-19" version="1">MVSFSCEACGDILTKKKLDPHRNQCRGATFTCIDCMVHFYGTDYRSHTSCMTEAQKYQGALYREKPTKNQRKAQQNNGKQNQKQNNAHGHRAPYVEDANDTDNPPAAPTPPVTGNDKSQEASTNGDKQVNVFDYLVAEKTPNASKVSLGGSKEQMKMVANAPSVFEPSKSLTRADTDAEEENKNYDVAYEENGYSYGAGPINQSVYDGKAPNASMEFMTPAPKKKKDRLRGEDKVNGTTSEKKRKRRTDDHDMEEADTPMLDAPSSVLNNPGTPMLKHSGLTGGLDRMLRSPSQDGEDHPRRRYQDPSSPIKRSRRDNKDANGDGLGISMKNRAERLVSSMFGGSSVSGSSVNSRETGKAARASRRGSPDEGRSKKLPKVRNASNGQAESDVSKSKRKSSAQTDGDRPSRRQKQIEHTDSRHDDNGREVVVYQQSGVPDGLQRQMATHFLSLVTKGPESTRGFSVNKVLKRFHRDFTDEFDDSDRGRDQGRSRADRERRADDEKELWRTLRLKQNERGEVVLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R951</accession>
    <name>A0A8G1R951_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_363801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000249526">
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="415" mass="45392" checksum="BAACAAC32CE68800" modified="2022-01-19" version="1">MLAVRDQENLVHSHQTVAASKPLNQGVRHLQPKTPGARVPKTPFKVPLKNDENDPLAFGKKTVKGGKQKENINLTTKNAFITPAADPRQRAPLGMKTTNAKARGLQTPAPPGGTVKPDRTIKRGSTQRAKKFAPFVEPSQPEVQAKPVEDDVPDIEYMPPKPKDLPDIPDDVTYDTTFPQFQPKNLALGLESVYGDNEVGPDGLTKRERKFQEDSAACDRMVEEMIRKQVESIGFEETYETVPIEEPPAADATQRRIQTRSRTRAANNKTKHTSNISTIRARDAAAALSGTQRSVPRTRPAVSAKPRVTSALFPSKKPREPTNPSSMRQTAAAATSQTTVGYSRGREVSTKLHGRTASPTELETVPQGILSPDTYLQPCGTPPLIADTIGLDLENAEGLPTFDEDEEAQNFQLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9E3</accession>
    <name>A0A8G1R9E3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_262637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517092.1">
        <property type="nucleotide sequence ID" value="XM_025655033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9E3"/>
    <dbReference type="GeneID" id="37158435"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="70" mass="7717" checksum="2592818A5A3BA2C6" modified="2022-01-19" version="1">MPVIPSGSDFPPQQGNSDNSASNQEQRNSDQGTQKATMLDHLSKGPQIPDSMPPKVPREEIEARMKELNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9E7</accession>
    <name>A0A8G1R9E7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lethal giant larvae (Lgl)-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_415455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518207.1">
        <property type="nucleotide sequence ID" value="XM_025657691.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37161093"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000848">
        <property type="entry name" value="SNARE-dependent exocytosis protein (Sro7), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="576"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="804"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="5">
        <location>
            <begin position="848"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1229"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1234"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1259"/>
            <end position="1271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH60285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1329" mass="144764" checksum="8A9DD195D95E83FB" modified="2022-01-19" version="1">MSPSLSTILVPDLEPSYTLGSILQRHFSSSVQVKGVYPLKGHLHSISRLVLSNGVQLLLKCSPGSTTPLLRREQLLLETEARAHSILVQQDTPYIPSFLHYGLHGGPLGSAFLVRHYVNGATLQELEAALTMQERDDLNRALGSLAREIGQNFSSSFGSLDQVACGSGKQSWREAFVTLLEGILRDSEDAFVHLPYAEIRNQVRRLSPALEEITSPQLVIVGLGRPSQVVLNPGSKKLAGLLGLENTLWGDVHMAEIFEAPSPAVLEGFGTRLKANKAQVARQLLYACYRAVHQVTIHYYRDQGMAAEIDARRRLTSILAEMASVDGICTSVSARMAHFLRGKQAGIQQDFSENLSPDLFALDDFARCGINSQISAIAYDPVQSLLAVGTSDTQFGHGQIYVFGQRRVAVVFSLPRKASAKFIQFCADKLVSVDSKSEISIFSLETRQTLVSYAPPSHASALLTDPSLDYAFIGLQNGDIIAYDLDRETLTPFRVPNLWAQRNARVRLCPVLSLSFSPRDIGKILVGYPEGAVTFSFKQNVAQKYFEYEVPPGALGGNGDVPASEMRRPRLTRALWHPNGIFVLTVHDDNSLVFWDSKDGRKIMARSINTPNVDQPGVSPERPQSATGLKDPITNIAWCVKDNGDDSGLLIAGGRPKAEANKGLTFIDLGPTPNYQTSSWAMIAKYFETPKRTAILPTPPGAEVVDFCPIPRSTPYYGGAHDPIALLALLSSGEVITMSFPSGHPITPTNMLHPYLSFVHPFVNKVTLTSVDRSAWLGLKEKRSQGPKFLLGGAEVRKPLKRFEDRNVLTTAHADGTIRIWDAGVDDEIENGDVVQVDLARAVGRVGNVEVTEMSFGGSTGELSVGLRTGELVVFRWGNNQSFGREEAPGANEGPGKLTKITHRVDPGLKTGILPLTLLNMQQGPVTALKHSQVGFVAVGFEGGSLAILDLRGPAIIHTAHFSELFKVNKRGSIFNKRSSESPAPEWPTSIEFGVLTLEGEDYSSICCFVGTNRGNLATFKILPGEGGRYCAQFVGTSLLDDKVINIIPVNADDGGLALATPNSVGGLRNGVRVHGVVVAVTVSGCRIFKPATSKGAHRSWDDYLCDSAAVVKTEARGYSLVGLFGDGYTRAFSIPGLKEIGASPINQIADMRRLSDATISSNGTVMVWTSPSEVGLFSVWGGGHALRQSEDQLYNPQAVMPPRPTITNIQWISGTQYVSPADMDILIGGPDRPPSKRMQEQMRLDEEERRKAFREGRTPTNKSSSSQEGYLSYMSRQVQERTERLNFAGDSMDRLEESSSNWARDVNKFVSNQKKKAVLGALGSKFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9W9</accession>
    <name>A0A8G1R9W9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Drug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_466017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520181.1">
        <property type="nucleotide sequence ID" value="XM_025662103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9W9"/>
    <dbReference type="GeneID" id="37165505"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF36">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="30"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="485"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH62259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="529" mass="57265" checksum="B521BBB5726FC0E0" modified="2022-01-19" version="1">MGDIYSEAELERLGRMRPTIFPNLLSELGFCFSLVLSQIMAEYFISGFNVLLPSLAEGLDIPEASSSWPSSAFALTAGGSLLFFGRLADRYGGFVVFAGGLAWHLVWSLVAGFAKNALMMYFCRALQGFGPAAFLSAGIMLLGTTYRPGWRKNLVFSIYGACAPIGFVAGIFVSGMTGQFLDWRWYFWIGTMLLFLALIAAVLSVPASIRRKPPHPDMSIDWAGAGLFFCSLVLIFFAINDCGHAPDGWRTPYVYVTLIVGFFLLLAALYVEGWVAKEPLLPLSLFRIPQLSSLLLGLFCFYGVFGIWLLYCVEYMENIMHASPLLVVAYFVPFALGGIFFSLIGGLFLHVLPGTVLLVISGIGWLMAPLLFAIMPLGASYWPYVFPAMICGTLGMDVTYNVTNIFVTTSLPERQQGLAAAVANSVLFLGISFWLGWGDFTSAQVHGDLRARYQAALWMAVGLAGLGLIIMVLFVKIKPAKSEVTVDEKEGGSAGSAGSGGSGGSGDTELMPKQETDIGVNGRDGNDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9Z5</accession>
    <name>A0A8G1R9Z5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_467256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517392.1">
        <property type="nucleotide sequence ID" value="XM_025662176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9Z5"/>
    <dbReference type="GeneID" id="37165578"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF5">
        <property type="entry name" value="GENERAL AMIDASE-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="82"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="235"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH59470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="540" mass="58727" checksum="C78639AC8A95F91F" modified="2022-01-19" version="1">MAVEQWETIVQQKQADAAAKIPQAWRLPAEFTENVSETTPTNVLDVPRKCGLLSAKQLEITENYDATALLEQIHSGKYTAVEVAEAFCLRAAIAQQVTRCLTETFFDLALERAKELDDYFQSTGKVRGPLHGLPISLKDCFNVAGVPSTIGFTAFVAHGPVKNNSSVVQILLDLGAVLYVKTNIPQTMMAADSHNYVFGRTLNPNRTSLSAGGSSGGEGALIAMRGSILGVGTDIAGSIRIPAIFDGTFALRPSIHRIPYGGQTGSGRKGLAGIRPCAGPLATSVRDLGLFMKLVVDADPWQYDSSTIFSTWRTAPPKETLRLGFILEDPHFPVHPPILNTLTRAVDALKAAGHEVINLTTPSLKDALLLGFRTFAMDPARTAFSHITKSGEPRIPALATTDLPSADLPYEWAPHTLESLYDLNVQRETICEQFRQLIVQNKIDAIIMPGYQGTAVAHDAVGWVPYTVLANVLDYPATIIPYRKANKADDAKYVRDVTYRPPYVAEDVEGAPCCVQLMGRTMHEEELLRDTATIANVLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA64</accession>
    <name>A0A8G1RA64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_390700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518941.1">
        <property type="nucleotide sequence ID" value="XM_025656780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA64"/>
    <dbReference type="GeneID" id="37160182"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.20:FF:000003">
        <property type="entry name" value="Nuclear pore complex protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="819"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="819"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH61019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1043" mass="117832" checksum="AA7AC229657ED9B1" modified="2022-01-19" version="1">MAPLTRATGSGAPAGFTSINPSQQPTNESDVIEIEDDDDEPMDEEGDDMEPNEDEDMEDDYVDEDEESEEEAADALNGSESPLDLGFAPNGHNGIDAATPDLFTSAGAQEALHPLRRTADRVTRQIEAFAEKLDRFKQKGNRSDDLSNYQAAYNLVKSYQTLAQDAISDITKQNTLKRAKLGLGAARSNGSASFDPKTAEELRRLQLEADTWRLLLNLISRDDPPRRADSKKSQESVFQNLHRYSPDRDVWDQFLTADHYATECVIILKWLERSAKYSTQDVDYLISELESQAERGQGSWSHGWLYTKETIKGQKRLRAWPQPLEPNDPGITATLLSSDKSEPLVTQLDPDAVTRQRQSLQKQDQFYERATWMTCWKMLRHGESWFKIREWCAERLEIWRAVSICGTSVDVETHTGRTPVDDGHTRLMNWRSQESWRAACSALARNPHAEDFERAVYALLCGETEAAFKVCHTWDDYLFVHFNSVLLSRYQGFCKQFQRKLSHSPTTPVAFVPEPAGYAEFNKFVQYTRGNERVGSEARNPYRTIQATILGKGYDAFFYSLAQAVSQVANNKSDASSFVPDVSPTSVDDSLVIAAEDGDALRIATHLYIVAHSIGYVRADTQFYNTACVNIIGYIANLESLGVVDIIPLYASLLPEDLTRSVLAQVLIEIVDPRERKNLVRLMEKHGIDVEAVLQTQWEWLSVNVSAIDHSRTVKRHPKVVNRKDGNLELVPVKTDFIGNEISESDENVIRSLEWLRYVDGQWGRICQLGSLLYRKFYISGRLSAARELCRRMKLSDISREMFGFDISEFSLDVAAMQEVNTPEPSSPTKSRLLSSPHKRSRSRTSGVASGSQASILLQQSQTMRDLEVLILALDALERYAIIYEKLENNKRRRDSGMLKDLREGLQEALDDTSVQIDVMLDEWLVNYENEAEKEELEEIRNTYIPEVFLDYHNTMYFSAHVLSSELLVQCMNLATQVAEVEHLTSSFVAARRVGELMNALAVSSKSMVNTHAKPGVRLLGGESLGIWAPQVSDEENDTTQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA90</accession>
    <name>A0A8G1RA90_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="6">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_416888</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Vacuole membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517527.1">
        <property type="nucleotide sequence ID" value="XM_025657753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA90"/>
    <dbReference type="GeneID" id="37161155"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="8">
        <location>
            <begin position="144"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="10">
        <location>
            <begin position="377"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH59605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="507" mass="56668" checksum="1316CF88BBEEC46E" modified="2022-01-19" version="1">MADFVDPRMTSVKPRIRYNTIGGINGPLVVLDNVKFPRYNEIVSLTLPDGTERSGQVLEARGNRAVVQVFEGTPGIDVKRTKVEFTGHSLKLGVSEDMLGRVFDGSGRAIDKGPKVLAEDYLDINGQPINPYSRVYPEEMISTGISAIDTMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKRPTKDVHDGHEENFSIVFAAMGVNMETARFFTRDFEENGSMERVTLFLNLANDPTIERIITPRLALTTAEYYAYQLEKHVLVIMTDLSAYCDALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIFIDRQLHNKGVYPPINVLPSLSRLMKSAIGTGRTRKDHSEVSNQLYAKYAIGRDAAAMKAVVGEEALSSEDKLSLEFLDKFERTFISQSPYESRSIFESLDIAWNLLRIYPKDLLNRIPKRVLDEFYARSARKIANKDTRDNTVSEQTQGETADLIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB43</accession>
    <name>A0A8G1RB43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxin-20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_434463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519734.1">
        <property type="nucleotide sequence ID" value="XM_025658467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB43"/>
    <dbReference type="GeneID" id="37161869"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.230">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="386" mass="42227" checksum="333F552C949AA10D" modified="2022-01-19" version="1">MSDALCGPSNALQNFQKHASVDRTLQQDRIISRQSPSQGFRSQNSSQGVLDPEFAAFESGLAGAPLPDVQHAGPFVPPSQHFPVSGPAESSNWAADFQNMHISGPSHSFHQTSGPSVAPMAAMSQQGWQNEFAQQQRPSFQQHQPHVQGLQPTFAPRFPMTGAAFPPAQATAANQQPMADTFDESAFEAAFEQARADMMSQETETAPVHAEEVVEETNYVTAESTEEKIKIGSDTIPQTEKNDQQARVNDADELARTAGQLLDSVKYDQSQKFRESNFLALMRRIRDREVQIEGDEFREIPHPLHPGGKYYPERRKARQGQTIGDTDHHARGDATPNTTSAMHGISSKGNSTSITSGNNPESSPGGFGPSGDYSVYGDWHHGDRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBL0</accession>
    <name>A0A8G1RBL0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1776-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_389302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519974.1">
        <property type="nucleotide sequence ID" value="XM_025656742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBL0"/>
    <dbReference type="GeneID" id="37160144"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013952">
        <property type="entry name" value="DUF1776_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08643">
        <property type="entry name" value="DUF1776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="460" mass="50389" checksum="03D5AA2CB1D8458A" modified="2022-01-19" version="1">MTSDDQFFFDYLASIPHDVRRYSLQVAESIDRQVDHAANALRDTLSSQSWLPTSVRPVSRNRPSPPIPRGFVDRVHTWFLRNRAWSAAIIAFLGTSCVLYYGNKKLNGKRRRARRAGNGARKEIVVVAGSPHEPMTRAIAADLERRGYIVYVTVTSAEEEHIVQSENRADIKALWLDLSATPSSPSEIHPSLNEIYSLISRPQSPMAGVPPHTCQLSGLILVPSPNYASGPVATIPPSSWIDTVNTRLLSPILTTQIFLPLLTLRNSNSTIVVAYPSISSSLSAPFTGPEVATTRALSGFATSLRRELSLLQQNNIDVVELKLGNIDLGSQYRNAQSHITGTEVLAWSVQQRSLYASQYLNSIEQRPAASAGPSTIRGSPARALHYAVLDALDPPSKDIFGRRVAKNSVIYVGRGARTYHFIGEWVPAGLVGWMLGLRTGQQTPPENGSGGSSETSWEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC67</accession>
    <name>A0A8G1RC67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endo-rhamnogalacturonase F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_360497</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521090.1">
        <property type="nucleotide sequence ID" value="XM_025655554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC67"/>
    <dbReference type="GeneID" id="37158956"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF18">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034832974" evidence="10">
        <location>
            <begin position="19"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH63168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="482" mass="52231" checksum="4A3764B7DCB6534F" modified="2022-01-19" version="1">MRLPSLIPLSLLAGLTAGQLIGPVGPTTNLEDKTIECNILDYGGVADNQTDVAASIEATFGECVLNNPKSRLVIPEGNYLIKRSVVLSNGTNWAFQLDGLITAAYGGNWTADRELILQGFAGEQIINSTINGEGDGKFLLDVLVIVNAVDFEFYSSNGLGAFQGQGYIYRNLDNTDRPRLVRLISPTNASVHDLILVDSPKFHIVFDFAVNLEAYHLTIRGANLGSYDGIDAIGTNYYIHDNEASRNPSHHALVENLVCNQAGSGVSIGSLNVSAEISNIEARNISIIQGNNIAFIKTYPGGSGYVRDVTFENFRSLNSLYGLDINQYWQNTWEPDTGSVTLSNLVFKNFSGSVADGALRPPLYLFASDLTFATNVTVEEFSVWTETGTTVVNKISNIFGTGDDSYGENDGIESLQSGESPYTYTSTYTITASPTNWQAPSTPTWALPSTGYGTASPIPVYTPAPLWRPGGIDYNLHYWGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCA1</accession>
    <name>A0A8G1RCA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP-binding protein ypt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_2019</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure membrane</location>
            <topology evidence="8">Lipid-anchor</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520473.1">
        <property type="nucleotide sequence ID" value="XM_025654544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCA1"/>
    <dbReference type="SMR" id="A0A8G1RCA1"/>
    <dbReference type="GeneID" id="37157946"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH62551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="201" mass="22303" checksum="8DC1A5B0BEBDF378" modified="2022-01-19" version="1">MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTVKLQIWDTAGQERFRTITSSYYRGAHGICVVYDVTDMDSFNNVKQWLQEIDRYATEGVNKLLVGNKSDMEDKKVVEYTVAKEFADSLGIPFLETSAKNASNVEQAFLTMARQIKERMGTATVNNKPTVQVGQGQGVQSGSAGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCT9</accession>
    <name>A0A8G1RCT9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2 type zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_362740</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520007.1">
        <property type="nucleotide sequence ID" value="XM_025655637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCT9"/>
    <dbReference type="GeneID" id="37159039"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003641">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF14">
        <property type="entry name" value="C2H2 TYPE ZINC FINGER DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G02360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="35"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH62085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="699" mass="77529" checksum="F9C2EF9789797A13" modified="2022-01-19" version="1">MIATAFRPNTGSKPFICKECRRPFARQDALTRHEKLHTRAANAKQAQVQQSSVHVPPQTTSLDALPWDASRAPAPPIVSTSASNQAWETSQAEQHPGLQHAASDLDFALIWPDSENLFQSIMSSDATDQWQMPLGALPFPPVVQDVNGMNFGSPNSFDDRGSSIGTIPSGGSHQAVRDVTEMVTSSSSSVTAAIKATSITSVFLDECLHMFFVRFIPTFPVLHRAIFVFRECTHPLLLNAMALGSLYLGPKDSVAKGEALWRLAHTAIATSWQSLITHRGPYDVCKGVQLLITALLGQIYGALSKNRVIRTTSQVFRPLGFLWARHCGMLDADPFPMENVPFPNSPSTEKEYKWRTWAAREIQQRALLAYHILDGLVAQMSGDSASTRHVANPLHLPSSEAAFDAGNVDEWIAIMRTQKVEQPSFRLVFRSLFPPIGSFRPLDFQFSAFALRVVLEGLQSLVSDSDESDLAAVGVPGRSDVRRALAQVHETITMSIHLSAPERLEVLLRWHTICLDTMINSTVLCRHVCSRYDITQHVSGGSRTIKPGFDMAKWVNTEDARRALLHAIAIQDIVEQLPRGRAHVIHMPSSLFSATTIYVVFSLAGVANIHLPRTIVWQDALLSRADLNLGCENIRPSTGSETRRFVEEGRTDSPPGMGAVRNLLYEMNSLQKLFRCMFSQWGIAHDMEEIIDQWITLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDI8</accession>
    <name>A0A8G1RDI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_364638</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519222.1">
        <property type="nucleotide sequence ID" value="XM_025655704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDI8"/>
    <dbReference type="GeneID" id="37159106"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16207">
        <property type="entry name" value="EFh_ScPlc1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13360">
        <property type="entry name" value="PH_PLC_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000396">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000201">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037755">
        <property type="entry name" value="Plc1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="403"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="783"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="897"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="685"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="751"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1107"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1111"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1136"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH61300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1156" mass="128418" checksum="1249D4235851DA7E" modified="2022-01-19" version="1">MAYAAASSPSTINGDTQASLKVTGSLPKPPKLHNVNTSVPPAPNPSSAPPCASIYSYTPNSLRPSHTFSNASSPSGTPLQSATDALRGRIPSFPLIPPAHLELGDSMMAVPGNASASGSGDAATQTTNKGPGLMRRISRGAANKLTRRRQSATQNDKRDRSSGPVIMRRRSDSKTGQNSWESALESSNEEDSNDALDSLGVWCGSEASSLQNESFSPPTRIVSAVAPKVDAMIQRGTVLTKVTKKRRKQVRFFFDIDAGKVYWDISNPTKRFYIDDIKEVRVGVDARNYREEHQVSQDLENRWFTIVIADAERLKGRAVKTLHLIAPSDHTFELFTTTLEHISRYRIGLMAGLAGSGQSEAVLKAHWQREMSRLYPKGLKPDELESLDFEAVESVCRSLHINCSKNMLRAQFSKADNNNKGKLFFSEFSDFVARLKERKDVKAIFKERAVSFEGFTLEEFLAFLRDVQNEDVESDRSYWVSIFDRLVRKSRPRAPSLPEHSDGTPTGVPRLGLDAFTSFLSSSWNGVYASRAPQSRFDRPLNEYFISSSHNTYLLGRQVAGASSTEAYISALSQGCRCVEIDCWDGADGRPIVSHGRTMTTSVLFADCITVINRYAFISTDFPLILSLEVHCNPEQQLAMVKIMKETFKDQLVLEPLLTNTFVLPSPEELKRRILVKVKTCDETDGGMRQESSGSLISVGRKRSSSSPFMQPTVPEYPPVSNLVPLAGSSTAGQDSVDTFLSQDRRSFTTTSLSSATEDSDGALTSMKRERKRRQKSKITKPLSDLGVYTRGYKWHSFTSAESQRYNHVYSFAERSFESICRDSDSKAVFEKHNRKYLTRVYPSGFRLRSSNFDPLKFWRRGVQMAALNWQTYDVGMQLNQAMFAAGTDRTGYVLKPESLRTVTPGEDKWKSTGRKRVNFTIEVISAQQLPRPRSLGPDDNINPYVEVEIFSADDRGQSFVIGEGGLNASARSGVSGIGYPHRRRTKIEQSNGYSPIFNDCFKFALETKYPDLVFVRWTVWSSLDGRSAGNNSSLQLATFTAKLTSLSQGYRYLPLYDAGGDQYLFSTLFCKITKDGITPASIERPDTEELRAERLGILRQIGQTVFKRSSSTEREKEAFSDKGSEIPISSEDNHSPTSPTLTPTVSAASTSSLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RE33</accession>
    <name>A0A8G1RE33_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cse1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_387677</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521309.1">
        <property type="nucleotide sequence ID" value="XM_025656679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RE33"/>
    <dbReference type="GeneID" id="37160081"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000057">
        <property type="entry name" value="Exportin-2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH63387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="962" mass="108899" checksum="26B8BB68E4CB523F" modified="2022-01-19" version="1">MADGLGAVAQLLEASLDPRQNKQAELALRQEEKKPNYSLQLLQITASASYPYNTRLASALCFKNFIKRNWTDEDGNYKLQAEEVTTIKRELISLMISVPTGIQTQLGEAVSVIADSDFWERWDTLVDDLVSRLQPNNPAVNNGVLQVAHSIFKRWRPLFRSDQLYLEINHVLERFGSPFLALFEGLDAYLEENKSNKDNLVQGFTQLNLMIKLMYDLSCHDLPPMFEENISGIASLLLKYLTYDNQLLHTDDDTEAGQLEFARAGIFQVLTLYVQKYMDEFKPHIGQFVESSWSFLTLIGQETKYDILVSRALQFLTSIAGMTEHAAVFQAEGTLGQIIEKVILPNVSLRESDEELFEDEPIEFIRRDLEGSDSDTRRRAATDFLRRLAERFEESVTSVVLRYTEHYLSEYAKAPATNWKAKDTATYLFSAIAAKGTATSSHGVTATNKLISITDFFQKHLAADLINDEGVHPILKVDAIKYLYLFRSIITKEQWQEVLPMLVKHLGSSEYVVYSYAAIAVERVLYLTDSQGQPIISPATITPLSKDLLEHIFSLIQKDQAPQKVQENEFLMRCAMRVLIVIKEGIVPHTDSVLQHLITITKIISSNPSNPRFYYFHFEALGAFIRFAAPANPDKLEQALYAPFAEILQGDVQEFMPYIFQLFAALLEANPSGTLPDYYQNLIAPILMPVMWESKGNIPALVRLLSSIIHRGSQYIIQNEQIAPVLGIFQKLLSTKTNEGYGFDLLESVVANFPPATLEQYFVSIMQIILTRLQNSKTENLTLRFVRFYHFVSAQDDKGYSADFVIQVIDKVQPELFTPIYLNIILPETQKLARPLDRKTAVLSFTKTLANSEAFANRYKKGWGFTCEALLKLLELPPLPASKDDIIAEHDVEDMAFGVGFTALNTVRPQTRDPWPDTGADLKAWTGKYLKEADKKHNGRISGFVQERLGAEAKTVLLSYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGD9</accession>
    <name>A0A8G1VGD9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_454260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510126.1">
        <property type="nucleotide sequence ID" value="XM_025661242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGD9"/>
    <dbReference type="GeneID" id="37164644"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="271" mass="30679" checksum="191CB8668CBC27FE" modified="2022-01-19" version="1">MDSFLDPNMTEIRLQPCPSQRKRIQNRMAQRKFREKAKAQKQSHPPGNQANTIGNGKSHDAPPNLPSRITDPEPHDNGYAYLTTGNHVGPLSAFACSIPGLLADNVQGFNHNIWDDAIFTLPESIEQSPYDLQTSSLEEQFFKPCSPTGADCSILDPNLAFFGKPQDQQKGQRPEERHRCRPTNNTCHCDRGHPNPPKHAHRIVQYQRAKLLYQTEQLLEKVESLYDVGISLGVLVDNNHLRDLIRRAIEGFRSQRGLETYNRAEEHLGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGW4</accession>
    <name>A0A8G1VGW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Multiple drug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_431109</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510636.1">
        <property type="nucleotide sequence ID" value="XM_025658320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGW4"/>
    <dbReference type="GeneID" id="37161722"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000266">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="58"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="540"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="582"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH52714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="597" mass="66016" checksum="1CAEAAC782A94CC8" modified="2022-01-19" version="1">MAKIPHWRLIVDQSVVTQEIIDYPYVGSGTESDPFVVEWIPNDPRNPMLFNKNIKWVYTIIAAFATFGVSMASSAYAGSIDQVIEHFNIGTEVATLGVSLFVLGFAVGPLVWAPLSELIGRQLVFFVSYMGLAVFSAGATGSKNPWTIIILRFFAGSFGSSPLTNAGGLIADVFPAEQRGLAMSVFAGSPFLGPTLGPVIGGFLGQSAGWKWVEGFLAAFTGFIWIIQFLLVPETYAPVLLRKRADRLSKLTGKTYISKLDVERGRVSVTSAFGAALLRPWILLFAEPIVFLLSLYMAIVYGTLYMLFDAFPIVYQQLRGWNEGVGSLPFLGVMVGMMSAVGYNMWDNKRYKRVHEKHRGFAPPEARLPPSMIGSITIPIGLFWFAWTNGLNVHWIVSIIASAPFGFGMVLVFLNIMSYLIDAYTIYAASVLAANSIIRSCFGAGFPLFTTYMYQNLGIHWASSIPAFLSVACLPFPFIFYKYGAAIRRKCKYAGEADAFMRKLAEKSLNPEKGQEVVEEEAEAVADGVDETRVDRELDLERAESVATASVSSDEREGRKYEANPYDIDRVNTRNSAITQRSRSRSVKSKRKKFLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHA7</accession>
    <name>A0A8G1VHA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="8">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_429736</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="8"/>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511071.1">
        <property type="nucleotide sequence ID" value="XM_025658262.1"/>
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    <dbReference type="GeneID" id="37161664"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000023">
        <property type="entry name" value="ATP-dependent (S)-NAD(P)H-hydrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
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        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <begin position="180"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="233"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH53149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="370" mass="39579" checksum="02B58E10626C5B86" modified="2022-01-19" version="1">MESSVHHITTSSKVLLKKARNLVPPMLEKFHKGQQGRVAVIGGSIDYTGAPYFSSMASARLGCDMSHVICDKSAAVVIKTYSPNLMVHPILPSSDNVKDPESIDAPSLASPIISMLSRLHCLVIGPGLGRDGVTLKVVTEVMKEARSRSIPFVLDADGLLLVTEDPDLVKGYKECILTPNVNEFSRLAKALGIDVPSQAEIGSKPGGGDKTSEETRACEQLSQALGGVTIIQKGPHDIISNGVTSIVSDIQGGLKRSGGQGDTLTGSLGTLLAWRAAYHNGLWDSGEQDNKKEAETKQDVQAELESENKRMSPTTTLLLAAFAGSSITRECSRRAFLAKGRSMQASDLTDEVHESFLQLIGEPEASKMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHA8</accession>
    <name>A0A8G1VHA8_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_492310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="39"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="140" mass="15198" checksum="53177430A3E3FA70" modified="2022-01-19" version="1">MSVFLRNRLSLRATPSSISARQLAPLRSAYYPLGQRLYAHSSYGGEGDTEAQQPNNPRNQPTRDIEHPGPPAPDTGSAKSSSSSSSSKEPSNKAHPTLADGDESPYVDKDGKTSADAPEDVRRHNEEIEKRADRPSERVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHD1</accession>
    <name>A0A8G1VHD1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_454011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510412.1">
        <property type="nucleotide sequence ID" value="XM_025661180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHD1"/>
    <dbReference type="GeneID" id="37164582"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08951">
        <property type="entry name" value="DR_C-13_KR_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF274">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH52490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="261" mass="28354" checksum="AA19E9DAC056F241" modified="2022-01-19" version="1">MARILITGSVDGLGLEAARQLVNRGHTVYLHARNEQRAMDAKSACPGAAGVLTADLSRMEDTQKLCDDANAIGEFDAVILNAGIMQGGFRKNANTGVPALVSVNLIAPYVMSCLLRPPKRLVFISSNLHRYADMASMEDMFWFKRGETSYQSYPAYCDSKLHVMLLANAVARRFRNTSVTSVHPGWVATKLGGQGAPDKVEDGVETYVMLAEGNYDEQNLSGGYFEPKGKIGQPIPAARDENLQEKVVEACEEVTGLKLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIA3</accession>
    <name>A0A8G1VIA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_442172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511387.1">
        <property type="nucleotide sequence ID" value="XM_025658828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIA3"/>
    <dbReference type="GeneID" id="37162230"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="177" mass="20475" checksum="1DD22D31E3889B29" modified="2022-01-19" version="1">MNVDTSLRLALRQITTQGLLRKCPSQLRPMDILKGRLIHHKAHHHSRCNIQPRWRLNKSPQDVYSRVTKRQEKRNVAQAFFRPLHVVAVSICCCDWYASFGREYSGGYCEQLNLPNGRIGHFCILRPPFALLAKKNRDTFAPDSTNIANNLEWLYDVLLNIICPGKKSEWSYDVQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIT2</accession>
    <name>A0A8G1VIT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_523573</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511509.1">
        <property type="nucleotide sequence ID" value="XM_025665361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIT2"/>
    <dbReference type="GeneID" id="37168763"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1150.12:FF:000002">
        <property type="entry name" value="Disulfide isomerase TigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000032">
        <property type="entry name" value="Protein disulfide-isomerase A6 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034803628" description="protein disulfide-isomerase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="8"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="131"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH53587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="359" mass="38592" checksum="247A65196ABF1A69" modified="2022-01-19" version="1">MVRLSNLVSCLGLASAVTAAVVDLVPKNFDDVVLKSGKPALVEFFAPWCGHCKNLAPVYEELGQAFAHASDKVTVGKVDADEHRDLGRKFGVQGFPTLKWFDGKSDEPEDYKGGRDLESLSSFISEKTGVKPRGPKKEPSKVEMLNDATFKGAVGGDNDVLVAFTAPWCGHCKNLAPTWEALANDFVLEPNVVIAKVDADAENGKATAREQGVSGYPTIKFFPKGSTESVPYEGARSEQAFIDFLNEKTGTHRTVGGGLDTKAGTIASLDELIASTSAADLAAAVKKAAAELKDKYAQYYVKVADKLSQNAEYATKELARLEKILAKGGSAPEKVDDLISRSNILRKFVGEEKEAKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIV6</accession>
    <name>A0A8G1VIV6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PKSN polyketide synthase for alternapyrone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_503670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511584.1">
        <property type="nucleotide sequence ID" value="XM_025664247.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37167649"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="8"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="932"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2272"/>
            <end position="2346"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="932"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1088"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="964"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH53662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2353" mass="256595" checksum="BBABB10DBA6F0EE9" modified="2022-01-19" version="1">MNNTSSCPEPIAVIGLGCRFSGQAASLDGFWEMLRDGRKEHGPVPGNRYQAAAWKHPSHERKGAINHDSGFFLEEDPARFDAPFFSITAKEAAGMDPAQRLLLEVAYEAFENAGVPMESLPGSSTGVYSGCMTNDYELLSTRDIMDMPHNSATGNGRTMLANRISWFFDLRGPSIMMDTACSSSLTALHLATQALRAGECRMALVCGASIILHPNFTQRLSYMHMLSADGISHSFDSRANGYGRGEGLGAVLLKPLSQAIADGDVIRAIVRATGANQDGRTPGITMPNAEAQADLIRATYQQAGLSMRETAYFEAHGTGTALGDPTELSAIGASFGEERTPNDEPVYVGSVKSNIGHTEGAAGVASLIKVVLCLEKGTLVPNAGFMTLNPKIQTERWRLRLSDITQPWPSHLPQRASINSFGFGGANAHAILESVAQYFGTAPQTIPRLPISIAQLVVVSTHDKAGLDRTAQKWMHALEASSDTPPLTDLAHTMATRRSKFGFRSFVVADTLGGLKETLGRGLASFPRARRQQQTALAFVCTGQGAQWAGMGIELVAFPVFAASIHHSQEVLTALGCQWDLAEEIRAHASTSRINRPDRSQPVCCALQIALIDLLSDWSITPKAVVGHSSGEVGAAYAAGYLTHEDAIRITYFRGVFSQRIVENGPSGGMLAAGVSEETARDYLKALSLESVVVACINSPSSVTLSGNNDQINHLAEYLQARGHFARKLRVDTAYHSPYMRALADDYRDSIASIKPVNLHQGKVAMFSSVTKTRVQHPDELGPDYWIRNLVSPVEFAAAVGQLATMSEAGPRRRRAVAVPWSAILEIGPHEALRGPFTQTVQEVNAGLTSLPYLSLVQRKKDALHTSLQVAGVLWSIGCPLEIDWVNRSLLGDHKPQLSQALLPSYAWNHQSSYWHEPYESSQLRQRVQPRHDLLGVACDYQNNIEPRWRNFLRLSEHPWLADHVVAGSIVLPAAGMVAIVAEAARQLTESVTLAGIDFHDLEFFRGMVIPSEENGLEILLHVSPHAVSGWYQFGIFSRPEESPWVQHAKGSFTMDYAGEEEQMEDSTTALNWARTVQQARQTQTAANVAVDSEAVYGWLSETGGVTMGPTFRTMQRVFFHPTQSRLFASVIVTDTKSTMPHEQESPYFLHPSSLDSLFQAAVLSCSEALSNQNAQIPIAVDRLYMSTRFSPSTGEQFNLHVETHWDEEGISRSEVVASHPTWSHPGLVLQGVRLGRVPIQSRPSAAVENVPQSRFSSLVWAEHVDSWAEHCDGTLSSWLRSVCHTHGDARMLVVAAESRFDHLVPALQELVPTGKYRPQLQQLTVILVDMSPDGSSARVQALQQILPNCQLLPVLTLAEVASSLPDEGAYDAVLLDHPNLWTGRQVFPLLDNINRVAQPDGWIIASIPAGMQDEVTENLDRHADWKVHGIASQTNSLLIHRRNEASSLLDPIIYVLAPEPADIFNALLQELIPLIEEQGARVERVSPHEVSKLKDKQVISLMELHESWTLRWTPADMECMRTLVQAKYILWVSPAPLDTAASYAATGATTGLLRTLRNENPNLDLPQLLIEEKDVARNPGHLGRSIARLLRLSHQSRSRPQDYEYLLRDGRLHVPRAIAYSPLDDAMEAAVHGPKPILAELTEDTRPLRLHSKSSDLEGAQWQLDDRLATAIAEDEVEVHLHAISLPSTTAKTTEARVQLTEALGTVCQVGQSLLSVFSVGETVLCVIPGQTISTRVRLPESSVWTCPPQQGPAQSLSMPIAYSTAYTSLVNGMHQVSGSVLIVGSVNQTLRATVHCALAARMQVFVAVDGVVEELRAQYPVLKDRIIPLHRSLPTTIARLTSGRGVDLTVCNLAGAASRQAASCLAPGGRYIDLSGDLQLSALPQKILEQGCTVTTISLSRMLRDTPRLIQANFHRAVDLIGGHKLLVQVASYPVFPVSQVDEAISHARHSGTRVILDLQAPGPVAVRPVQPEPRPLPSENTYLLIGGLGTIGLSLASALVDSGARHIVFSSRSGATQSSQQAALDALHARGARTEVIRCDVACEHDVKQLLTHAAYHNWRIRGIIQCATVLKDAMFDQMDWESWQQSTRAKIQGTWNLHQAFQATRPLDFFVTLSSISSVIGNMGQANYAAGNAFMDALMEWRHKHNLAGCSINLGLVEDASGVTDVAESSEQRRQRYRHVLGTEISQAEVQTLIRLLVQGQMQPAPPAQIIAGLIDVLPREDGASPWQFDRKFDHRAWIADPEAQAATGPVKTSVLLKRADSIEESISLVSQALQTYLARAMGAAPDSVDLDLPLSALGVDSLKATEMQTWVSRELGAALSSFELLSSQPVRILAEKITAGSSFVAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ69</accession>
    <name>A0A8G1VJ69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_471166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512317.1">
        <property type="nucleotide sequence ID" value="XM_025662452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ69"/>
    <dbReference type="GeneID" id="37165854"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05289">
        <property type="entry name" value="MDR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="12"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="359" mass="39229" checksum="8514DEF79C37A4FE" modified="2022-01-19" version="1">MEMLSLNISTYSKPSEYQVSKLPTPTLVNSKDVIVKVYAASINPIDVKRADGALKLAVKDPFPYKIGYDCAGVVQETGRDVKKFKVGDAVYIRLPEVSRGSCSEFIRCSEEHIGLKPPSLSFEEAASIPLAAMTALQALRLYRGDLAGKTVFVPAGLSGTGLFACQLAKHVFRAGKVITTVSTAKIPKLKELLGENTIDQVIDYTNSDPRDVIEHGTIDFLFDTVGLSMELLCLMRPGSSRIVSVSTLPSGNQLQDSPLMALPHKPTIPFAFRMGLNLADQVRKVRARRYKTEYSYMFLVSSGKNLDELTRYVEDGRLKTVVGSVVDLQDIEAVRKACGTVYSGRGGLGKLVIRVRGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJL9</accession>
    <name>A0A8G1VJL9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_470110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513696.1">
        <property type="nucleotide sequence ID" value="XM_025662372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJL9"/>
    <dbReference type="GeneID" id="37165774"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH55774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="390" mass="43559" checksum="DC09080A9588A9B4" modified="2022-01-19" version="1">MSDFASYLGIASALNLRYKEARTAIDRLGCPVDDTLGRLRRSFPSLNEKLCAFRPLNETTAVDAIRELYTTLAVVLTNSPGPDPTRPLPLSRHSSSLRVSGDVTFACVMYASCWFGDYVPSSIPLVLEIWCAWFPTRQSDADVCFVPANHQYVGTGQHDARYELEGHNARGLVRRHRALNINSFRDIMVLRSGMLVSDCVDHDNRDIVAFLQKAAQLPALIIPSEAIDLWSGQPLAELDRLGLYIRQVKHLTVCTPSPRRMTIIYTFLYSLTSSRQNAHVRGRITPDSKKSVSCCPAPFCSQNAPPRELDRDLPLSHSSAWNPLRLVLQAALQEGLAAEEWQVSIDARVRLCDEWSRGLQPQFGQYNPVAAAVDVAPLCIRIMLRLAQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJT3</accession>
    <name>A0A8G1VJT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_164167</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510985.1">
        <property type="nucleotide sequence ID" value="XM_025654254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJT3"/>
    <dbReference type="GeneID" id="37157656"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF116">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034645172" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH53063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="470" mass="51944" checksum="2C84767FF761CFE6" modified="2022-01-19" version="1">MWLSLVCSILLPLGVVNAQSQYLNDKTKEFVVNGSALPFVDFDIGESYAGYLPNTPSGISSLYFWFFPSADPNASDEITVWLNGGPGCSSLAGIMLENGPFLWQPGTYRPVRNPYSWNNLTNIVYIDQPAGTGFSLGPSTVVSEFDVARQFMDFWRRFMKTFDLQNRKIYLTGESYAGQYIPYIASQMLDQDDDKYFWVAGIQINDPYINEVSVLQDVPALATVNQHRSLFPFNDTFMSQITQFSDDCGYTSFLEDALTFPPLSKLPSVPYNASCNTWETIINASLALNPCFNRYHIPDSCPTPWNPVGGPVVGQGPTNYFNRSDVQKAINAYPTDYFVCKDGIFPTADGLDTSPPSSLGPLPRVIEQTNNTIIAHGLMDFELLAQGTLISIQNMTWNGKQGFEREPVEPLFVPYGGPSGGGVLGTAHTERGLTFSTVFSSGHEIPEYAPGAAYRQLEFLLGRVANLSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJY7</accession>
    <name>A0A8G1VJY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_375852</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513878.1">
        <property type="nucleotide sequence ID" value="XM_025656192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJY7"/>
    <dbReference type="GeneID" id="37159594"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH55956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="293" mass="31874" checksum="767ACB9D6AB143F1" modified="2022-01-19" version="1">MSITCTHVTPECPVTATTYGYYPNLGGNIFFAVYFGLLGTLQLGLGVYYRSWTMMIAMVIGGYMELAGYIGRILMNHNPWDQSGFKLQIVCLVLAPTFIAAGIYLTLKHVILSLGPEYSRLKPQLFTWIFISCDVGSLILQAAGGGVAAAAGSENQNLLKVGDDIMVAGIAFQVGTMSVCGLLALDFFIRVVRKGPGLGGEKFIDENGNLTGPKNLRVVVWAGIVAYFATLIRCIYRIPEMAGGWGNPLMQKENEFLVLDGMMMAIAVSCLTFLYPGFFLESIRKGMKKTPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKI3</accession>
    <name>A0A8G1VKI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-haloalkanoic acid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_151176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511660.1">
        <property type="nucleotide sequence ID" value="XM_025654146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKI3"/>
    <dbReference type="GeneID" id="37157548"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF9">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="237" mass="26856" checksum="6EB7CF5627F55D64" modified="2022-01-19" version="1">MSQLSNYRLLSFDVYGTLVDWEGGILAAFQPSLDKANAHFTREHLLTVYHDLERAQQAQTPDMPYSQLLATIHPQWTERLGLPQPSEEESRKFGESIGNWPAFPDTVDALKRLAQRYKLVVLSNVDRASFAKTNAGSLQGFPFDLIITAQDVGSYKPDLRNFEYLLKAVKEQFDIEPAQVLQTAQSQFHDHHPARKMGLKSAWIERPGATMGNLLETVYDWRFDTLGEMADAVEKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKS9</accession>
    <name>A0A8G1VKS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_374105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514778.1">
        <property type="nucleotide sequence ID" value="XM_025656112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKS9"/>
    <dbReference type="GeneID" id="37159514"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH56856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="169" mass="19111" checksum="BEB01FD2F1162508" modified="2022-01-19" version="1">MASFQDRAQHAIAQLDKELSKYPVLNNLERQTSVPKVYVILGLVGIYFFLVFFNIAGEFLVNLAGFLIPGYYSLNALFTAGKADDTQWLTYWVVYAFFTVIESAISAPYWFPFYYIFKFALVLWMSLPQTNGAQIVFHSFIQPVLGRFFQGGSTSANLRAQAEAAAKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL26</accession>
    <name>A0A8G1VL26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_469224</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515078.1">
        <property type="nucleotide sequence ID" value="XM_025662318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL26"/>
    <dbReference type="GeneID" id="37165720"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000306">
        <property type="entry name" value="IKS protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000699">
        <property type="entry name" value="Probable serine/threonine-protein kinase iksA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="739"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="809"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="833"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="868"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="895"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="937"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="970"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1007"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1048"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1074"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1105"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="148"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="16">
        <location>
            <begin position="745"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="91"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="469"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH57156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1211" mass="131888" checksum="8D041F75C1A88DE9" modified="2022-01-19" version="1">MADEGMSIVPYGSGNLDVVLRHNDSVVVFDRDSQQLVLRHAAESDDGNLELADCPYCHRPLRDSSSAQDDHHGGTQPEFINPHYFRMLHNSLPSSVSSSSPPSPRRRLVPPALADGPTSEPSYSGSGIHSTQGISSAAFTQDYFKKFFVEETVLGKGGKGVVLLVKHVLDGVSLGQYACKRVPVGDDHEWLEKVLAEVQLLQHLTHQNLVSYRHVWLENAKISTFGPSVPCAFILQQYCNAGDLHNYICGSVDTPTTTEQLKERLRRKSRGGPEPPSDAGGLRKLNFEEIYSFFKDITSGLRYLHANGYIHRDLKPNNCLLHKTSDGIRVLVSDFGEVQAQDSMRRSTGATGTVSFCAPEVLRRDYPGGPFGNFTFKSDIFSLGMILYFLCFAQLPYTHADLIHEEKEDLDQLREEISHWAGFDDAQFIRPDLPGQLYTFLKRLLSLDPDGRPSADEVLSGLQAGANVNESFRSRRTSPTSPDIRPSARIHPVESTDTPSFRPSSSPNKSLTRSPVAVRRNPLYESDGADAALRPVVEETSPLSERNTPLSPENDMMVRPWFSSAQSHSPAQAEHREVPQERPQPVQQLLPPPPGRFSLARVFPGAASLIDSQIPAVALQLAAFLLKVVSTFQPCSPLAVNPWVAYPLLLLAAVNFPAAGLWTQIVSLLLHLLISLCPLPGMAISPEAIELSEATHPGEGFEKVQQVPEDVVGDTTVLQNDEAKPEAEPEPGEAIYPHGVQFVLISLSLCFCVFLVGLDATILTTAVPRITDEFGSVADVGWYDAAFRLTSCMSQLSQGKLYDNYPVKWVFLVNLLLFEGGILLSGLAPSSFIFIIGRAITGLGFSGISQGCMVIIAISTPLRRRPTFVGLISASEYTAIAIAPILGGILTSDLSWRWCFYINLPAAALPSAVLLLLKLPTITPRGSKTHIQKLRELDLLGFFLFAPAVLCLLLALQWGGDTYSWTNGRIIALLVLSPIIFTGFCLLQHRKQDTAMLPPRVLRKRIIITGAAFSLCLSACRAIVQYYLSIWFQTVRNATPLQSGLNTLPLVISVLISAITGGWLISRTRTYTPILLPASLLVIAGIALMTTFTPTTPAKLWIPSLILLGLGSGSAVGVPFIAVQAILPLKDISIGMALMTFSQDIGEAVFISVAQAIFLNRLTGDLAESVPGLDPVMVMHLGATSLEGKLPGKYLEAVIGAYDVAIGKVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMH0</accession>
    <name>A0A8G1VMH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_498873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513610.1">
        <property type="nucleotide sequence ID" value="XM_025664039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMH0"/>
    <dbReference type="GeneID" id="37167441"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35396">
        <property type="entry name" value="SMALL SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35396:SF1">
        <property type="entry name" value="SMALL SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034551187" evidence="1">
        <location>
            <begin position="19"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="147" mass="15307" checksum="A77C6BBA3C1848A3" modified="2022-01-19" version="1">MQTKSLLTILLSAALAAATVDPASSNTKGKCPGTYNCSAAKTSTAIQAAECSHNTRTSGTQTFAVFVTDHEYDSSYGAPYGTCKAYTCTAPTDSEMTDDDDDCWTFFWNDNGESSGVGTGCIRSPDDGTCGCEDSDGTFVYGGSNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMN3</accession>
    <name>A0A8G1VMN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_436998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516818.1">
        <property type="nucleotide sequence ID" value="XM_025658599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMN3"/>
    <dbReference type="GeneID" id="37162001"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="301" mass="33372" checksum="C8034EBBA1CD8D2C" modified="2022-01-19" version="1">MLNVLPLHSSYDLADTSSHMTVMGRSLCLSTAFRFVFSVPEPLGLWRYQHTSHHYTTQPSVISPHTFHKRPSSEKSNKSPSSSSSGSSGMRLGNAKSVDWLAVYRHGFSQGTSRTTSTGDSTNCTNSQPIGCRSDAFAEGFGGGRSVSLSSTMKISLKTGQPAEIVRGDADKSDRFIRLGFLMTEDLQKKPVLIAMDTMAEVSIMRKGIFDKLGLPLHHFSMDIVPLQTRSAETPIRPIGLVRHVDWHFALAPRTYTTEFLVVDTDQYDVLIGEREIKRYHLLHLGADIPDVVVRPLEKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMQ3</accession>
    <name>A0A8G1VMQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_437053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516878.1">
        <property type="nucleotide sequence ID" value="XM_025658605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMQ3"/>
    <dbReference type="GeneID" id="37162007"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034994822" evidence="1">
        <location>
            <begin position="22"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="26"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="552" mass="60853" checksum="9FC7A2C95455EC1A" modified="2022-01-19" version="1">MPSFTTKGLAAVALGAAAAQAQLWDQVIQTNYGPVKGFKYFTNETVLEKFFGTTESNVTAFLGIPFAADTGYQNRWKPPQPREPWNTTLNATSFGPACPSNYETYISEDCLSLNIWTNAASADAKLPVIVWNQGSDETSDTAWWYGGGMAMKDVILISFNRRDDAFGYLALPELNAEGLAATGHNTSGNYGVLDQLEVLKWVQKNIANFGGDPDRVIVAGQSFGSSQVYHAVNSPLFSGYFHGGISESGIRYPYDPLLAGLATSYVNMSTAITHGESYKSAHNVSTLAELRELSMEDLLVGSQDRVNGTWIWWVTALSAGYPLIFKPVLDDYVLPSTYLETLINGPANDVPVITGNTKDESGASTTTDYTVHEYLNYTSLKYGDLFDRYIKLYPTDNNQSTADRSWNAAARDASLIGSWAYATDWYKAAESDFYTYYWTHAPPGQDQGAFHQSEIMYALNALYANADTYPFTDADYEIAAKMSAYWANFAKTLNPNQGGSYTGKGSLPNWAPNSPNGTQIVMELGNYFGNVPIAHPDQVKFMMDYFLQQIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMQ6</accession>
    <name>A0A8G1VMQ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium-binding protein NCS-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_69784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513865.1">
        <property type="nucleotide sequence ID" value="XM_025665599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMQ6"/>
    <dbReference type="GeneID" id="37169001"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH55943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="190" mass="21997" checksum="9E626D5B1D2033C5" modified="2022-01-19" version="1">MGKSQSKLSPSQLEELQKATHFDKKELQQWYKGFLKDCPSGTLTKEEFQKIYRQFFPFGDPSSFANYVFRVFDSDNSGMIDFKEFICALSVTSRGKMEDKLDWAFQLYDIDGDGKITYDEMLAIVEAIYKMVGSMVKLPEDEDTPEKRVRKIFRMMDKDENGSLDMEEFKEGSKRDETIVSALSLYDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNT1</accession>
    <name>A0A8G1VNT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_511321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516834.1">
        <property type="nucleotide sequence ID" value="XM_025664586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNT1"/>
    <dbReference type="GeneID" id="37167988"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="228" mass="25294" checksum="6F91FFA51A2A70EB" modified="2022-01-19" version="1">MPVLRYQQDLNYIPPPDIPTTRNRKRKLRGSIPWLDTGNQEVPGGKYYASDEAIVNAALLLFLQAVTGLSGNHDVKWTIECVSFQLDFTNARFTTITDGAMVTKNSGKTRGLCEVKRKQLGHTDQSAATVSMQETAELVGLIKKNGSTVFLNGQHLLTSQYANEIYLLFAKAQVSYHEYLNTGAIGNDDFLVIQRCGPWRVSDPACMEQLVVIILAIVLLADKARFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPD2</accession>
    <name>A0A8G1VPD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_417107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517642.1">
        <property type="nucleotide sequence ID" value="XM_025657761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPD2"/>
    <dbReference type="GeneID" id="37161163"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH59720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="506" mass="56359" checksum="E4000DF4413F07C8" modified="2022-01-19" version="1">MRLWKHDFRGRALIIAITMASCQAFLLLGFDQGVMSGIVGADNRFARDFNNPDAAMQGNITGLYDIGCVVGSIICYFIGERMGRRTMLMMGGFIMIIGTVILASSYTIAQLLVGRIVTGLGNGMNSSTAPVYQSECSPAEYRGALLTLQGTVTILGVVIAYWMDYGTSFTDSSYEWRLPLAFQAVFAICLILQVVGLPESPRWLVQHDRHDEARAVVAAIEDTTIDDANVTKTIMDIQFVLEEEQKDGPFRVKELFTWGEVQNLRRLFITITIELGQQFTGSNMINYYGPVMFQETMNMSRNLSLILGGAMQCTYLVGSAIPVFLMDRYGRRTLLMVCSAGLCLCFVMVSILLSLDREDCAYGATVFIFIFQIFYGVGWLPVPWFYPAELNTTRVRTRMQAIASGWNWMAVFAVVKITPIAFDNIGWRTFVIFAVLNAVFIPMVYFFYPETKGLELEDIPLLFHKGGITGGVFTSKGGRTVTPGQHALEARVDQKVEGTVQQVEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPS3</accession>
    <name>A0A8G1VPS3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_468626</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
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        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
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                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">CBS 112811</strain>
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        </source>
    </evidence>
    <sequence length="1673" mass="183935" checksum="66B6903C495D92E3" modified="2022-01-19" version="1">MALSSASVDRFPSEPGQPQIDTLSTSVNPGTEAKVLASADTQYATTDLRRAHTVAHGRNTKESPTIGSRTTRERLATSLLRVKDSHEISRKRSFKRLDTSQAPRDAAVGAREPNHFTVGNVGQNGKIFLRPIRNPPTKEPFPTPSIPSPSQSRQEPFPHGRGGPESDEPSRWSNSQLSELRPDLIPEESCEDGDSVHTESARSQYHGLPHHRPRKAHSFSTISEQRSESRAGRAGELRIYIDRADNRPKTANEPSQRALEDSIPRYRLDLPQASLDNETALHSSIYSRTSMSDIMRTSRLPREYWIGTLASDTYLRNPERPSFVGSVFSGAGAIELPRSSAVSENPVFYELKEPIEPAIFETLVSEMDKESVVRYASGTKDISAATPARIVAQISSASFMDYELVSDFFLTFRSYISTSTLLALLLARLRWAINRLQDDGRIIRIRTFAALRHWILNYFVDDFVPEYDLRGHFCETINSMYDDVKSRQGGGMSDLKILIDLKRCWYGKSSLYWDLPSDHDVFQSPDVAILPGDREADTLEMAGGGDLLTLVRTKSGLDASPAGTQYRPNHHSRNNSSNTVKSVPISAGSDRSFQAISCSLPPKSPKRLSLSLANKAPHPVPLMPLKPTSSREAYPPSPLTSRRYPYLGHSHKRSGSFSDSVRDDRAPFSLVNPEQQGVAARQEALDLSSLIRGELYPPAESYTIMMAPPSPPLPSSAKDLASDRRSTSHGIHKPAASTSGVKTIIGSIRRALNSRHGASGSLSRAMNRPANASLPGRTSALPTNVAFGSDAYRGRKTATGAKRPTRIDTLCDEVLKQYRAAISEQTDTTGGSQSADSQNQAEIHSSAPGMPRATSQVTAGSESIVIVDGTGLGLPVMSGAIGEANAGLQQPPGFLEAEPSPATVRAPSPYAPHQRSTLATDEYSLPIFYDEPNPGPSSRASKFLRPSRFSEASRRSYSVERASTSWKRTSSSLRLRKYASFQSGVSKHRLTMGSDSIPPLPPGSLQQPLDKPSGPTLRRRPGGDLRQMRNGGGFQSRPDSGSFISDITYRSSGADTAVTRVDEPYSRPQTSLIPPNPRFSLLTTHSSQNLRRSFEDAIAQFAQIPDDDDGGVESTLLKLEGKWHGTSAGDAEASAAGSDPYLQHYNPGEVTGEDWLRQSRGSAGPHSFANSNAVARRRQTFLGDGLTYSQVQGRIVPQRPYSDSIAESEDSYSSIPLLERGLSDESMKKPVASRPTSHMAGPSHFQPSFSSRETSDVESSHPSIDIVKETESMKRIPRGSTLPGISSGSRKHTGRLSGLSSGLSIDMIDSQEAAEQRFSIDTQSMTDSSLGIPPHPLAHPPSPPMTVQNTRSVGSWTTPLNPVLFQAQPLTPDPSPRNKMAQQANTRPVNTQQVSGDVLSQSERGRRLPEPLKTVGPEHVPFVLSCESHVLAQQLTLVEMAALSEVDWRDLVDMRWSSGSPTVLSWVQFLMEDEHRGIDLVVGRFNLMVRWVLSEIVLTQDIHERARTIAKFIHTAAHARRMCNYATMLQIAIALSSTDCSRLQATWDLVPVSDKRLLKDMESLTQPIRNFHELRLEMEMANAQDGCIPFVGLYVHDLTYNAQKPARVTTQDGESLINFERYRTTAKIVKSLLRLIDASTRYRFEPVPGIIERCLWIASLSEEQVQLRSKQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQX4</accession>
    <name>A0A8G1VQX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Squalene cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_456790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519144.1">
        <property type="nucleotide sequence ID" value="XM_025661473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQX4"/>
    <dbReference type="GeneID" id="37164875"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016866">
        <property type="term" value="F:intramolecular transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006400">
        <property type="entry name" value="Hopene-cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01507">
        <property type="entry name" value="hopene_cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF82">
        <property type="entry name" value="TERPENE CYCLASE_MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="4">
        <location>
            <begin position="28"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="3">
        <location>
            <begin position="329"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH61222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1127" mass="127171" checksum="C1A6ADD56C55D113" modified="2022-01-19" version="1">MALRREGHEEWVTSGKEQLTSDVERTLKLANDYALGSIRSDGHWCGELRSNVTITAEYIFLRHALGLDLRADNAAYCNYILSQQNCDGSWGLAPEYPGDVSTTTEAYLALKLLGVSPHMPVMQQARAFVLKAGGAEKVRVFTRIFLATFGLFPWDAVPQLPVELILLPSSCPINMYTLASWARGTIAPLLIICHHRPVYALPDDYLDELWLNPTDKNVPYGSPLRDLLCQGDITGLAFSVVDNLLYYLNGLRSVPLLRSYARRKCLQWILERQEPTGDWAGIFPPMHASIYAFVLEGYELDDPPVRLGIQALENFAWEDEKGKRIQACVSPVWDTALMSIGLCDAMSPDKHVLQQAITWIRYRQLLKPCGDWRIYRPKLAPGGFSFEYENSHYPDVDDTAAIILAQLKQDPQSVASDSVIAAATWILGMQNPDGGWAAFDVENDKLFLNKIPFSDMDSLCDTSCADITGRILEAFGLMMRRESKRPILSPMLRYACTRGITYLASTQEANGAWFGRWGCNYIYGTSHALCGLAYYMEDDKRVSGLVAPALQWLKSKQNDDGGWGEPLLSYRTTGTQLQQQSTPSQTAWALMGLLAHLPLTDPAIERGIRWLVCSQRPEKGIGASWPEAFFPNFSRARPATVPTDKVVPLRYWDDLDYLRRLCHDFTFRFDDVLDASKLDAALARLTEIGDWNQLGARLRLNDQNRLEYHIPAEYTKARPAYNFTTTEYGLRISEHELGKQLPQSGQDQSILSPSPAVFAPIVRHADSPRKLADWIYTDRPQLHIHVSVFQDATLVTVSYVHTLFDAIARSTFFNAWIAVLRGREDEVPPFIPFEHDPLRTLGTEAPVKPYSNFDRALSGLSLVIFGLRYLWELFWYQQEEEHPIRLPRQCVERLKESARKELAAMSPDNEDKAPFLSEGDVVMAWWVRTIVTALNPAPDRTIMVMNVFNVWALFEEWFPTGGAGFIGNAFFYSYTLLVAGQVIQDASLAYVASKNRKALMEHRTKEQVQAMTSMQRASFTRTPPVVGDANLLFMACTNQHKARYFELDFSAAVVAPGVPLSERPHALGRPSYINDIETCQGYPTRNVVRIIGKDAAGDYWLLFKTRPGAWAVIHRQLVALLKLDEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR66</accession>
    <name>A0A8G1VR66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_444954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519444.1">
        <property type="nucleotide sequence ID" value="XM_025659150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR66"/>
    <dbReference type="GeneID" id="37162552"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="53" mass="6231" checksum="1A727CA12EFEFA0C" modified="2022-01-19" version="1">MGYPEGRGFHIVPYIVSTPLTNHVKIPTYLVPSHIFYYTLLYYTILYYTSPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRB0</accession>
    <name>A0A8G1VRB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Chitin synthase</fullName>
            <ecNumber evidence="2 9">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_501235</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 9"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519637.1">
        <property type="nucleotide sequence ID" value="XM_025664164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRB0"/>
    <dbReference type="GeneID" id="37167566"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF39">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="541"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="630"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="675"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="809"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="846"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="11">
        <location>
            <begin position="116"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH61715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="882" mass="99332" checksum="82AA875B6628A756" modified="2022-01-19" version="1" fragment="single">LESSGHQNNMDNAQDQSSRPLSFELESSHHSLRQLTPPIASSYSFNENDDASHSLLPAPLDNHHPSASSQGPPVIIQYNPYKDPHQQSESEATSQTSWQRRQTTKSVSGLRRYPTRRINLVQGSVLSVDYPVPSAIRNSVEAKYRDSSDATAEEFTHLRYTAATCDPDDFNLRNGYNLRAAMFNRHTEILIAITYYNEDKVLTSRTLNGVMQNIRDIVNLKKTQFWDKGGPAWQKIVVCLVFDGIGPCDKNTLDVLATVGIYQDGIMKHDVDGKETVAHIFEYTTQLSVTPSQQLVRPQSDSPENLPPVQMIFCLKQKNSKKINSHRWLFNAFGRILNPEVCILIDAGTKPGHKSLLALWEAFYNNKNLGGACGEIHALLGPRWEKLVNPLVAAQNFEYKISNILDKPLESAFGYVSVLPGAFSAYRYRAIMGRPLEQYFHGDHTLSKKLGKKGIEGMNIFKKNMFLAEDRILCFELVAKAGYKWTLSYVKASKGETDVPEAPPEFLSQRRRWLNGSFAASLYSVMHFNRIYKSGHNILRLLFLHVQLVYNICQLTMTWFSLASYWLTTSVIMDIVGTPSATNKNKGWPFGNAASPVVNNIIKALYLAFLMQQFFLALGNRPKGSQTSYILTFLYFAVVQLYILVLSFYLVAQAFAGGNIDLDFDNGAGGFVGSFFTSTTGLVLIALVSTYGTYIIASILYCDPWHLLTSSWAYFLGMPSTINVLNVYAFCNWHDVSWGTKGSDDTASLPSAKTKKSETQKSFVEEVDRPQADIDIDFELTVRRALSPWQEPMEEKEVQLEDSYKTFRTNLVLLWTLCNGLLALLINNDSVRNLCLTTTSTDRTAWYFKVILWATSGLSVFRFLGALWFLGKTGLLCCFSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VS49</accession>
    <name>A0A8G1VS49_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TBC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_227525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518365.1">
        <property type="nucleotide sequence ID" value="XM_025654753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VS49"/>
    <dbReference type="GeneID" id="37158155"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000055">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000023">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="552"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="832" mass="92378" checksum="0080839047DFBEC2" modified="2022-01-19" version="1">MVETRSASVPAVVMSDSASTIQTVPYDDTIAATAPIAVRSASYPTPVDCTSCSEETSHSASSGSAWEQSGSAPSQQNARSRRNRFTALPEAGASTVSLRSLRNSIPSIIVNDTASRPASRPGSRPGSRWSERRWGGLRSKKSGEFDRDDDAPPVPPIQAPFNGIALDIPNSALDGLGPQSMRFSKRGSLIKEESKRQLQQQIEQEEARRREAAQQTQDGDNQQQRGSDDREPASPDVASSEQNSTEPETIETPSRRSKPVSALRVRHSAMASRAISADEDMLSRRVRLMYEKGEENVTDSEVAKSMAMENGILWEDTPTSMETSRLSGPSMSVDTKSVVSSLGPENGPAIKREAHELAGGIEYWQNIKAGDVDRYGFIRSPTSNSNEGIDPSPIQRVSTSLLMASETPRRKHSIRPPSAIGGNRPFSGLTGRSPTRKMSEPSIRPTSSHSMYSTTMMRRSTSRFRRAANHLPHNRDRRVKDEASDMLTHPTAPLNPGEKQDAAAARAARKKEWEREDKWTKMARPMRSGDGGGMTFEFDTTSSKLIERTWKGIPDRWRATAWYAFLKSSARMHSDSPSEEELIEAFNEFQLVSSPDDVQIDIDVPRTITSHIMFRRRYRGGQRLLFRVLHAMSLYFPDTGYVQGMAALAATLLAYYDEEHAFIMLVRLWQLRGLERLYQSGFSGLMEALGDFEREWLEKGEVAAKLNELGIPPTAYGTRWYLTLFNYSIPFPAQLRVWDVFMLLGDADDLTAPGSSGKGSKKDAPTSAFGNGLDVLHATSAALIDGMRDIILESDFENAMKVLTSWVPIKDIELFMRVAKAEWKVHRRKKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSD9</accession>
    <name>A0A8G1VSD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_464833</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520762.1">
        <property type="nucleotide sequence ID" value="XM_025662012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSD9"/>
    <dbReference type="GeneID" id="37165414"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000328">
        <property type="entry name" value="Septin spn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="6">
        <location>
            <begin position="70"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="372"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH62840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="433" mass="49303" checksum="4CCBCFAD8CA81D19" modified="2022-01-19" version="1">MLLPSPFWPCCSEAYPCSFPLPLNPPRPLSLEPSFSFHYLSSGSRPEICPRLISCSNSQMKLRRKKNVKKGIQFCLMVCGASGTGRTTFVNTLCGKKVLEGKDCDDPANAHIEEGVRIKPVTVELELDDEGTRISLTIVDTPGFGDQIDNEASFGEIVGYLERQYDDILAEESRIKRNPRFRDNRVHVLLYFITPTGHGLRELDIELMKRLSPRVNVIPVIGKADSLTPAELAESKKLIMEDIEHYRIPVYNFPYDIEEDDEDTVEENAELRGLMPFAIVGSEDFVEIDGKKVRARQYPWGVVDVENPRHSDFLAIRSALLHSHLADLKEITHDFLYENYRTEKLSKSVDGATPHSTQDSSMNPEDLASQSVRLKEEQLRREEEKLREIELKVQREIAEKRQELLARESQLREIEARMAREASQSQIDSISDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VT34</accession>
    <name>A0A8G1VT34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_26272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521512.1">
        <property type="nucleotide sequence ID" value="XM_025655037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VT34"/>
    <dbReference type="GeneID" id="37158439"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="181" mass="20091" checksum="E648C2EC142BCD26" modified="2022-01-19" version="1">MLSIFRTSTTYSSVAPCMYNLLLRTSSTMDKQIRITSYAQFRLARPTPLSLSSAHLQTLNRVEPRIKIVSGEFQPVLRAHTKQVRDPTRAFYTCEINISHHCGVTARKCSVNRAKGATAILANLLPCKAARLAESVLPPLQVMISGTRPLCGHRKCCVIRGNTNIEPRQKAPLDLSTEISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VT46</accession>
    <name>A0A8G1VT46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_444820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521514.1">
        <property type="nucleotide sequence ID" value="XM_025659119.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37162521"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057068">
        <property type="entry name" value="IML1_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24438">
        <property type="entry name" value="IML1_N_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="DEP" evidence="8">
        <location>
            <begin position="1327"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="714"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="826"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="876"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1422"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1571"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1667"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1827"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="717"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="742"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="759"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="876"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="921"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1571"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1670"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1830"/>
            <end position="1841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH63592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1851" mass="208344" checksum="CACF152260D40ED5" modified="2022-01-19" version="1">MSLRGPMKRSHLRQVSAASIDTLSSSRTAELPRGTPRDRSSTPDDKAARLSSTGLDRRQCSLWVHDETFSKEEILFNQAAFSDTGVQVGDVIEILPARLSGDAPYAAKADMGARSLRESHVDLNSSLPANPMSKFKTPLQSRCLFVVKPLPQEIKTRHPKLELSVTSSVANIFGFKNRTAVHISIVERAQCSASHVDISFRDQYLVRSDMWRLVMSELSEKIVYKGQKIVFMGSIKATVKNIFIRGKKVLSGFFSPQTIPVFRSESAKYVLFIQMSREMWDFDSEGTGDILFSRVINGFLPELFKRWANSDARHLVTIVLFTRVEYDPSAIGPSSSLTSESLHNNFTPNGAPTRDFYRVVVNDMASGHWTTILDELKKDFRTFLRDVSILKTTDDIKTPTIDGVKVAPRAQSATIAGRPSTALRGNILEAIHLASSHLAYDHIDRDMVHTGTSIIVITPGSGVFEVSYESLASTTEALTNRGIAIDLVCLSPMPLHSVPLFKYREPAQRTQSPSYGGDIQDGGYSPEMRLSFASLASRGSHLSPKSFPGMGARPWSSHRNEWNYGIPHWLDISYWNPETYREARRILKKDPNAPIPFTVTKQSKVFVPRVRMYEIQMMGVMESEQSNISIPYLLEGQGISRRSNHAMALSPANISPGNLPFKRNSPFRHQLSDSLRPEPFLQNIASSKDAMLPKSRKSSKSVVSWMDQYDEGVFHPFPKRRQRPKPTKQKRPSEPEVQVSNAHDRLSARSVTRLRENETNSNERAQTTYSAPRKIDATLPVPKKPVPTRTVSPKKPALKTSSSARIPRISRTISFALRGLSATPPRAQASTEVNVEHARGQSTANVKKPTGMFADTRSVDSLSISDSASTKTVIDLSTTPTTPQKQSHNSSAITPSRPIEIKVPQKQPPEDDAEQGDRPITESYSTTTTEIPIPGEARHEGRAKRPHPRVTINGSSRDASKSAPSKALAPWVRSINPCNTPKDVLRDTSWFGRWQHAYPRPPHVAVVKWKSLKSPAILPLTTEEFPTATELASDYYQTPYRVFPNDDAEGVEPPKTRGVLLREMISLRLSHGFQIVVGKNVVEVSGQYSLEAPNVFDTRSLERDGATVFLSKGNTIHRLVCIDEAEIEVTRYTHRNSAMLASHKTNDFTMYSPAMRTILSPEYEVKNIRLDPTLEEYNWNYADNYVAGHREYLFSPAQQLQFWRARYVLIPMHLQVNSRRQLQSYNEDNEEEIHLLGINQLTHIWQRHKYVPPEEKLFDTARKKREQNPLNIMYQTRNSSEVVAAELDRIILTDPGLDNSPAQLLPESELLERSSISLTTLAQLIQGEKGVRMMDRRWHWRLHYNCFIGFELTTWLLQNFRDIDSREEAVEFGNELLKHGLFQHVERRHNFRDGNYFYQICSEYRASRPESRGSWFPQIRADKPAASTPTGENPRDSPISHSRSESLDEAAQPAPNTPSRGKNKAAIMLSKTMKYDVDPRKRSNRPEVIDLHYDRLHNPDNCFHIELSWMNTTAKLIEDAVISWASTAEKFGLKLVQVPIAEACAIDETQPFRKPYRVQLKLPPPKGPLPSLFQASTSSSTTPTSLTQPSPPDRHYYQKALLRRFDFVLDFEARSAFPADVEVSYSWGIPDYRYPQYIHRSGSLLVQITDDGDFLFLANRLVSTRAAATSRDRLDRDRDPQQPQHRTRAGTYDPGDRASPRLSPLTRPTILPIPHDASTSITNSPRHFPASTAAAAASLDSSNFYRAPEHILTNFEDFCRDPIRLEQFYSESHVRPTSTRVEPTALLDTAIPSLELPASVVSHHPHLGITSGPGLMSRASHNGTLPTIESRARASRDEGRSPRSGALRPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VTI9</accession>
    <name>A0A8G1VTI9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_445255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519775.1">
        <property type="nucleotide sequence ID" value="XM_025659216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VTI9"/>
    <dbReference type="GeneID" id="37162618"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="70" mass="8084" checksum="3C88E5237E6641FE" modified="2022-01-19" version="1">MQLLSALQAGLGWLYLLYTTIRCVCMMLRALLLRPSHYNKLSITNRPTDRPPDPPFLQLASTYLLTNKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QPY7</accession>
    <name>A0A8G1QPY7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BO85DRAFT_385805</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="17">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="KZ825097">
        <property type="protein sequence ID" value="RAH51673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509595.1">
        <property type="nucleotide sequence ID" value="XM_025656617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QPY7"/>
    <dbReference type="GeneID" id="37160019"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF423">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 18" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="881"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="914"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="951"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="994"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1031"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1063"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="167"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="20">
        <location>
            <begin position="266"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="908"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1133"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1153"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1171"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RAH51673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1185" mass="128721" checksum="E7C57B920A5877CF" modified="2022-01-19" version="1">MASTLSPDRLRVRSDTRTSAQSLDGETLRPRADSTISSADTAVRSRANSEATNAPTKMEYDDVSVADALNPDPRNEQDFIVPDNKFAFSPGQLNKMQNPKSLAAFQALGGMQGLERGLRTDLTSGLSVDETLLAGSISFSEATSPDYASFKETAPPNIDAPITESGTQFQDRISVFCQNRLPARKSTGFLKLFWQAYNDKIIILLTIAAIVSLSLGIYETTSEGSGVDWIEGVAICVAILIVTIVTAANDWQKERQFAKLNKRNNDREVKAVRSGKVSMISIHDITVGDILHVEPGDAIPADGVLVSGHGIKCDESSATGESDQMKKTDGHEVGRLITNGKATKKLDPFMISGSKVLEGVGTYLVTSVGPYSTYGRILLSLQESNDPTPLQVKLGRLANWIGWLGSGAAIILFFALFFRFVADLSHNTGTPAAKGKEFVDILIVAVTVIVVAIPEGLPLAVTLALAFATTRMVKENNLVRVLRACETMGNATVICSDKTGTLTQNKMTVVAGTLGSKSFKHTPGEERSSDVSTPAEFFKQYSGKQRDLILHSIALNSTAFEEEKGGSKEFIGSKTEVALLQMAKDHLGLDVTAERASADIVQLIPFDSARKCMGVVYREPTLGYRLLVKGAAEIMVGSCTTQMVEADPSHGHISIDALNEGNRQFILNTVEAYAGQSLRTIGLVYRDFPSWPPKDARCLEDDPESARFEDVFRDMTWIGVVGIQDPLRPEVPAAIQKCHAAGVQVKMVTGDNIVTASAIASSCGIKTEDGIVMEGPKFRQLSDEEMDRVIPRLQVLARSSPEDKRILVARLKKLGETVAVTGDGTNDGPALRTADVGFSMGIAGTEVAKEASSIILLDDNFKSIVTAIAWGRAVNDAVAKFLQFQITVNITAVVLTFVSSLYSSENKSVLNAVQLLWVNLIMDTFAALALATDAPTEKILNRKPVPKSASLFTVIMWKMILGQALYQLAITFMLYFGGNQIIGSRLGTDDPQTVLNTIVFNTFVWMQIFNEFNNRRLDNKFNIFEGMFRNYWFLGINCIMVGGQIMIIFVGGEAFGVTRLNGIQWAICIICALGCLPWAVVLRTVPDGPCEVALNFVVRCMNFIIKPIGRAMGYFAAMIRSCLRPVKRTAQRVVKRGGKEEQDTSTDALPDEEAGRASLHELKREPTPEAPVTSIPVPPITITTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QPZ0</accession>
    <name>A0A8G1QPZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acetylglutamate kinase</fullName>
            <ecNumber evidence="2">2.7.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_408644</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-acetyl-L-glutamate + ATP = N-acetyl-L-glutamyl 5-phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="2"/>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510013.1">
        <property type="nucleotide sequence ID" value="XM_025657408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QPZ0"/>
    <dbReference type="GeneID" id="37160810"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04252">
        <property type="entry name" value="AAK_NAGK-fArgBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04263">
        <property type="entry name" value="DUF619-NAGK-FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000046">
        <property type="entry name" value="N-acetylglutamate kinase / N-acetylglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041734">
        <property type="entry name" value="NAGK-fArgBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="10">
        <location>
            <begin position="52"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="648"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH52091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="814" mass="90504" checksum="CA04C4FCBC30897D" modified="2022-01-19" version="1">MPTIGQVYQLSKTEEDSSKIGTAFGDISILGEKVRKTQFANPLTQAILFLHPHLIQTYNPLKGRTLSTNGPIRAGELLMADLPYAVLPTVAVGDSEHSICSNLGCSRRVSRHAANSVTCETGCSLEIWWCNESCKDEDQARHDFECAWLKKYSPVLRQELGDHDYYMLWIIIRLLAARYLELQGTAPTNVHQQLTFQDRFVSGWKGVQLLRSNRDSWPTSQLQHWTTLAEKYLLQSSPLPETLDLDTLIDLICAEETNVFELCPGPTEIIPHQSPGVKRGTQYGLAVFLRITLANHSCAPNVTHQADDRGRMMVTALRDIAPGEECCTSYFDLSEYVDLQARRKKTQELFTFTYYQVSATRSTIAQLLNHIDCQRTAAQYLSHFTTPQSPTQQPFAVIKVGGAILDTHLHTLASSLAFFSRMGLYPVIVHGAGPQLNKILEDAGVEPHFEEGIRVTDGKTLALARRLFLDENLKLVQALEEIGVAARPITAGVFQAEHLDQKRYGLVGRITKVETAPIVSAMKASCLPILTSMAETRDGQVLNVNADLAASELARALKPKKVVYLAEKGGLVHGVTGKRIERINLSEEFEDLMAQEWVKYGTRLKIRAVEELLRGLSGTSSVSIVHPVDLQREVFAASGAGTLIERGTRIYSTTSAEFRDEERLVHALARQGAGDDEVRFCVNEMRRNRPLKMYFSDPSSLSPLAVVAFGSGGAPHLITFPSGIMGAGAVADDMFVRITKDFPQLVWNVRDDDDRLEWFSARATGRFQHGGWVMLWYGLNQQEARQLILGFQDGYERDRVGLETADIQGIAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS39</accession>
    <name>A0A8G1QS39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_492933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510521.1">
        <property type="nucleotide sequence ID" value="XM_025663807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QS39"/>
    <dbReference type="GeneID" id="37167209"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="102" mass="10182" checksum="A202EDE6293009EF" modified="2022-01-19" version="1">MNKAQYDPLILKQTLPTMAAPNRRPEYDTSGTGGNADAHYGCWRGSGGQTVTGGSGTGGNIQMPASRADANIKMTGTGGNARANAGGAAKGGDARGGNLTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSL4</accession>
    <name>A0A8G1QSL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_472219</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511020.1">
        <property type="nucleotide sequence ID" value="XM_025662539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSL4"/>
    <dbReference type="GeneID" id="37165941"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="39"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH53098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="468" mass="50236" checksum="C12A71D44DF6BE85" modified="2022-01-19" version="1">MSDRSRSAAEQESSLPQNADRALNSRSEPVPEPVYPQWHYVAVVAAGFIVMITTCAFVFSFGVYQSLYEEMAREPNTPFTGSTTALIDLIGTLAIALMSMAGPFAMSWAKLFSPQAVIIAGGWVFGIAYILASFSKALWHFALTQGLLLGIGTCMAYVPTMAVAPTWFSKRRGLAMGIIISGTGVGGMIWPPALRAMISHVGFRNALRISGCISLTTVTAAGSILRWEPKFHEQVKLQTAGSSSSTSRYRPKWIRLFSVPLVNWRVARSKRFTAQALGCFLQSAGYSTPLFFYAAYAQALGYSATTAANFITLSNASNFVSRIIIGYAADKLGRINALAATTLLSAVAVFAFWLPSSLVSSAAAHGLFIVFTILYGAFASAYISLFPASLVELFGVQHFTSVNGALYLVRGVGALLGTPLTGLLIPRGSALTESGIYERAAITVGVLLFAATVACFWVRAEVHGKWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSS0</accession>
    <name>A0A8G1QSS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_385197</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509836.1">
        <property type="nucleotide sequence ID" value="XM_025656584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSS0"/>
    <dbReference type="GeneID" id="37159986"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000673">
        <property type="entry name" value="RING finger domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="272"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH51914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="393" mass="43477" checksum="4072FC86703A3E87" modified="2022-01-19" version="1">MAHSKRNTSLPHFTSYERDLLKSSWGTKRGVIGRDSFLPFGSCRLCLHPAREPVVACATNGDLFCRECAISDLLAQRQEIKRLEKERDEAKKRLAEEEERALDEARTRELRDFELVSMGLDAAAKKNNGSSQSQNDESSKKRKADTTEALAAFKAREVEVDGKRKKVFELDDKEMARIAREEQERLKNELKKEKKLTDHPQEANKSALPSFWVPSLTPTTDPNEIAANKTIKLTPICPASTDSNRHSYSLKSLVEVHFTEEKTSDGSPARVCPSCKKTLTNGLKAMLTKPCGHVICQPCVNKFMTPHDAPDPHASKEEQEQTAALHGRILCYVCETDVTPSSDSNKESASSGKKKKKDKEGIRPGLVEVSSEGTGFAGRGGNVATKSGVAFQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSS5</accession>
    <name>A0A8G1QSS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_480846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511543.1">
        <property type="nucleotide sequence ID" value="XM_025663027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSS5"/>
    <dbReference type="GeneID" id="37166429"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="265" mass="29977" checksum="C932A0CE68A86F6C" modified="2022-01-19" version="1">MSRPGTPSMLFFDVLGTVVEWRFCIANQLKAAAERALQDQAEIAVDVRGRVSDLAPSTWNEITDEWHRSYMNFGRSFDPSKPFVSVDEHNRVSLSNIFTDRRLRDLFNDDDLQHLTLCWHRLDPYADSVQGLALLNTKFPTSTLSNGNVKLLEDLVEHGSLPFKHISSAEHFNAYKPAPEVYHAAARRFGLETSQCCLVAAHLHDLQAAKRCGFQTIYIERPLEEAWDAERVAQAKEEGFVDYWIGIEGSGLLDVALYFGIETDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QU91</accession>
    <name>A0A8G1QU91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_480891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511609.1">
        <property type="nucleotide sequence ID" value="XM_025663032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QU91"/>
    <dbReference type="GeneID" id="37166434"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="179" mass="20453" checksum="C2F7D54DB296764D" modified="2022-01-19" version="1">MSSVTIQSCLYGLYGLFINVIGYANVSRRLRAIDLQDCALAPLCCTYFRKLSNGRRQQLWSRILKLITEAGFMTLKPGNYKFTLNPTQVRNWPDFTKEIKGLVEPYCGKYEAFIPTISREIIGVANELGVQGRFGNNVLQFVGEIMDLMEIGVRFGDAQYGQLARYMDDHYCRYGFLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUL5</accession>
    <name>A0A8G1QUL5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_442710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510811.1">
        <property type="nucleotide sequence ID" value="XM_025658848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUL5"/>
    <dbReference type="GeneID" id="37162250"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="66694" checksum="18509098333FFD71" modified="2022-01-19" version="1">MSSGELWSTLVTAIDPGSTKAMPIILQSTIDLLETELAKARAALHEIQPTASSLFTKRDELALGAVAAYRQSLIDRAPDFFYGASRLTPKELGLVPAVREVQADDDEDDHVKTSSKQHLRPVQPIAPKRASLADVLSNSLILDHMAPYLSTSSLLALASTSRQVRSSIVDTPYIFRHLDLTQCRGAKPASTSATDLAEQVGSGEQGEDSAVEDEIHSAPLRGIFASLQRQSILQDVRTLVLDGLSVPADLLAEIILTDRFNVNILSIRECRHLNERKLMQVLTHAVRPSRPKGTPRVKGIYHFTPLQQSRAVIRSRYRDWWSSRCGSQSSITPSPENGSATSEVAESATPQQDAWYRSSGQLFKRSIEDGWAETIKQCEGIIAFDAVLCRGPRHDVDLSTPMPEDQSASQPEGRPPLAPKLATVALGPRGCDGCHTSPEGPTFWGQSPDENLPLLTPPPLHSSSVVEAKRPVLIPDEQPSLIARCTDCLTDRWCHRCNKWFCEDCLPHPERVRNNLSPHQTAFRNPQSNLGSTEQSEDHRQFSRGVSKDCWECGPTCVQCKTECQRTCQSCRGEYCVEHNEGCSSTMCDWCNASTRHRVRELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV77</accession>
    <name>A0A8G1QV77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uridine nucleosidase Urh1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_426437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512908.1">
        <property type="nucleotide sequence ID" value="XM_025658114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV77"/>
    <dbReference type="GeneID" id="37161516"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02651">
        <property type="entry name" value="nuc_hydro_IU_UC_XIUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF4">
        <property type="entry name" value="URIDINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH54986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="374" mass="39962" checksum="CB9F2426A9CE8588" modified="2022-01-19" version="1">MASSVDTPIPLWLDCDPGHDDAFAILLAAHHPSLKLLGITTIHGNASLENTTINATRVLEAIGRPEIPVYPGSKKPFCRPALHAPNIHGDSGLDGTDLLPKASTAPITDKNPILAMRDALMAHPKGTPWVVATGTLTNVALLFATFPEVAEHIAGLTIMGGGVGEGFTDAPMSRLEGQENRIGNVTPLAEFNIYCDPEASQAIFSDPVVASKTTLITLDLTHQVLADQSVRNLVRHGVDDASVEPTTLRQMLYELLIFFANTYETVFGLSTGPPLHDPLAVAVILSNLNPAYAKSHPDQVLKFDDRGGERFSVNVITDGLHGTDIALVGSLGRSVVEANPNAVCIPRGVDLDAFWHMINDCIKRADKCNAARKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV95</accession>
    <name>A0A8G1QV95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RmlC-like cupin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_452568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512119.1">
        <property type="nucleotide sequence ID" value="XM_025660850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV95"/>
    <dbReference type="GeneID" id="37164252"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40434:SF1">
        <property type="entry name" value="CUPIN TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40434">
        <property type="entry name" value="CUPIN_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11533" checksum="00CCAEC9FB617105" modified="2022-01-19" version="1">MAETYPIGTRKECERLVKDWGFKHVFTWADGSNAHYPPHSHGGVTTHLIRQGSLTITYPDDNAKLHNGEVKKETFGVGARLDVPAGKLHEVWIGDSGCEYVIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV97</accession>
    <name>A0A8G1QV97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase I subunit RPA34.5-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_430916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510767.1">
        <property type="nucleotide sequence ID" value="XM_025658306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV97"/>
    <dbReference type="GeneID" id="37161708"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013240">
        <property type="entry name" value="DNA-dir_RNA_pol1_su_RPA34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053263">
        <property type="entry name" value="Euk_RPA34_RNAP_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155">
        <property type="entry name" value="ACR243WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34.5-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08208">
        <property type="entry name" value="RNA_polI_A34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="33884" checksum="879BCA9ACA7F1CEA" modified="2022-01-19" version="1">MAPKSNKKAVEEREPTPMSTSSAGESSSSEVESTQSGSDSDSDSSTSSNEKTSTQKTSRNVSLAAPQPYKAPSGFKSLKQQAPPKSSVSSLLSDLRGKQVYHITAPDYLPLSKVEEVSLAKIMQGKPVLKHKGVQYGIPVESFAQPDLGGKTLHLYDSKTKTYYSTAASNIPSYHIQEMLDIPEVSDETVAQAVQEQIKPPRKHPKHLKMRFHPVGSGVEPPETLGSSSEESEDEKPTFKVPKSLEKERDERKRKNHPTEADGSQADAGDVPRKKSRKFAQEGGDGEDKKKKSSKSREEKKRKKSEKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVE0</accession>
    <name>A0A8G1QVE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="16">ATP-PFK</shortName>
            <shortName evidence="16">Phosphofructokinase</shortName>
            <ecNumber evidence="16">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO85DRAFT_453074</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 16">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16 17">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="16">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16 17">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion outer membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="16"/>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511484.1">
        <property type="nucleotide sequence ID" value="XM_025660981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVE0"/>
    <dbReference type="GeneID" id="37164383"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000010">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 16 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 16 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="19">
        <location>
            <begin position="15"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="19">
        <location>
            <begin position="404"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="16">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interdomain linker" evidence="16">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="16">
        <location>
            <begin position="404"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="116"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="162"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="206"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="297"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="537"/>
            <end position="541"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="575"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="582"/>
            <end position="584"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="668"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="674"/>
            <end position="677"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="749"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RAH53562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="783" mass="85721" checksum="89EEDADB139CD0E7" modified="2022-01-19" version="1">MAPTQAPVQPPKRRRIGVLTSGGDAPGMNGVVRAVVRMAIHSDCEAFAVYEGYEGLVNGGDMIRQLHWEDVRGWLSRGGTLIGSARCMTFRERPGRLRAAKNMVLRGIDALVVCGGDGSLTGADLFRSEWPGLLKELVETGELTEEQVKPYQILNIVGLVGSIDNDMSGTDATIGCYSSLTRICDAVDDVFDTAFSHQRGFVIEVMGRHCGWLALMSAISTGADWLFVPEMPPKDGWEDDMCAIITKNRKERGKRRTIVIVAEGAQDRHLNKISSSKIKDILTERLNLDTRVTVLGHTQRGGAACAYDRWLSTLQGVEAVRAVLDMQPGAPSPVITIRENKILRMPLMDAVQHTKTVTKHIQNKEFAEAMALRDSEFKEYHYSYINTSTPDHPKLLLPENKRMRIGIIHVGAPAGGMNQATRAAVAYCLTRGHTPLAIHNGFPGLCRHYDDTPICSVREVAWQESDSWVNEGGSDIGTNRGLPGDDLATTAKSFKKFGFDALFVVGGFEAFTAVSQLRQAREKYPEFKIPMTVLPATISNNVPGTEYSLGSDTCLNTLIDFCDAIRQSASSSRRRVFVIETQGGKSGYIATTAGLSVGAVAVYIPEEGIDIKMLARDIDFLRDNFARDKGANRAGKIILRNECASSTYTTQVVADMIKEEAKGRFESRAAVPGHFQQGGKPSPMDRIRALRMATKCMLHLESYAGKSADEIAADELSASVIGIKGSQVLFSPMGGANGLEATETDWARRRPKTEFWLELQDTVNILSGRASVNNATWSCYENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWG1</accession>
    <name>A0A8G1QWG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_80382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513060.1">
        <property type="nucleotide sequence ID" value="XM_025665677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWG1"/>
    <dbReference type="GeneID" id="37169079"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH55138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="153" mass="17102" checksum="7E5F644E94B75EC6" modified="2022-01-19" version="1">MGYAGLASRARLVVFYLWPSQKVGLLFVEQGFLITDCPSPCLFSANRARHGQITLENLFPQVAVLDDNYWASSAKSEVFILLQCYSGLITGFPLDFSGLEISMPEKHRKASDFSLHANSCHRSSISPLRFLVHFGPAFSRACLYCSEWVRGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWT8</accession>
    <name>A0A8G1QWT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_103770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512373.1">
        <property type="nucleotide sequence ID" value="XM_025653797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWT8"/>
    <dbReference type="GeneID" id="37157199"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="41"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH54451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="547" mass="58261" checksum="27494548E0413565" modified="2022-01-19" version="1">MTAQERPEGVPEETTPLLGESSNNGEDLARIQVSRWRGSAIVAAMGLLLFIMTTNMSMMTTAQSEIAADLDAFSETTWFNSAFLIAMSSLTPLSGRLSQIFTPRVYILFSCTLLSIGLFVTALAPTLAVFLLGRALTGCGAGGQMVIAFVLTLDLTSKKRRGLFIGLISAGMTTGVSSGAVLAGLLTPAYGWRIIFWVQAPLALILGPVQYLAIPKRPEDEHLSGRALLRRLAKVDYAGALTLTISVFLLLSSLAAAVVKSTPILLSLVFLGIFVLIESRFATDPIIPMEVLKKRSVLLSCLAGAICMMARWAVLFYSPVYALVVRDWSPATAGLILVPTNAGFGLGGLLVGWIHIRKTGSYYISGLIAFFLFALTNLVLSVLSTPHSSTVAYLAASFFNGLSVGAVMNYTLSHLLHLTDPDMHYVISALLGMSRGFAGSFGSSIGGGYFQRELKRGLETGFMKHGLANRGELVRKLLGSPALAKRLTGVERAVAVHSYEQAVKTLLLGACVLAIAAAAAQAGTGWTPYKGKKPQDPGDLEATAEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXL1</accession>
    <name>A0A8G1QXL1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_522840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512386.1">
        <property type="nucleotide sequence ID" value="XM_025665297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXL1"/>
    <dbReference type="GeneID" id="37168699"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="137" mass="15739" checksum="CBE02AAF2B70212C" modified="2022-01-19" version="1">MSRSVTVPCNALLDITFFGQAAQEGETCAKTQGVNIYSIGLNQTEVPVWESFMEQLLHFHRKNPTYDGRFLVQRYPIQEPLVTPKSDTAYPHRQIKMHISNIEGRYTDPYIEDPVNAFLHESRHHFQLSSGFDKLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXP6</accession>
    <name>A0A8G1QXP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_375709</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513735.1">
        <property type="nucleotide sequence ID" value="XM_025656185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXP6"/>
    <dbReference type="GeneID" id="37159587"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF37">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="483"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH55813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="64034" checksum="7A644AC05826A5A6" modified="2022-01-19" version="1">MSELCQGQDTVHPPRGYRELRSFVFSSRERRIDLLEAKVDQLLATSRNSSTTEESPASTASQSKDAIDKGLLTVDAANMLLNEFRATLMPHCPFVVIPPQTSAESLRRDKPFLFLTILTATLYDNMPLQRMLEKEVKKKISDCMIFDGPVSFEVLQGLLVHIAWCQYHSRPRRFSQYLHLAISIITDLQLDHAPEYRLWRTRVNFNPEEHKESVSWGHDERRAVLGIFYFSSSVSQILHKQCTFSYMPYFDECCKHLATDAEYASDQHLLHIVQLQRLSEKITSISAQNILGTHGPGSSSERSFREMKLELEQYRASLPCPLHENNILFMQYYTAELYLCQISLFDNKPSTQSPRREVSFQIEALRMGLVAAKALLDYYVCLPLRSEMAFNNAIWIQIGFALTLASKLVVAASEPSIQPHTAELCRALDISSMLSRCILRMQALVTSSMDASGDRDVFYHYEQRLKRVQWWFENRMLPRQKSDSFQPPVQPSNMSPSGAENNHLESAQLPLDGLNDYAVIPREVYDMQWPGFFPDATIDEILVDWMEYTKASEQRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY23</accession>
    <name>A0A8G1QY23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_452980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511362.1">
        <property type="nucleotide sequence ID" value="XM_025660963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QY23"/>
    <dbReference type="GeneID" id="37164365"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF2">
        <property type="entry name" value="DLTD N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G00380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="43"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="300" mass="33286" checksum="66EB4B93B314280F" modified="2022-01-19" version="1">MSSRQRVEFKTLDGLTLRGDLYPAETRGPAIIITPGFHLVKEILAGDIALQYQRNGVTALAYDPRNYGDSDGQPRNHIDSIRNVTDYSDALTFLKGLPMVDPNKIAFWGASWSGAVALGAASLDPRAKLVLSVCPMVQDINPSPASMKMLKNAMKDRESIVRGNPPFYVPIVNEEGKNPVGFGPAYSKDDYELSQRARNSVAPNFSPDMTLQSYFQLVQYDPVSTMRFLSPNTAVMLLTPELDEISPAHLQKQIYDNVPGPKRLFWAPGQPHRGVVTGDYAEEGLQKQIEYLWEVFGPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYJ0</accession>
    <name>A0A8G1QYJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_461013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513844.1">
        <property type="nucleotide sequence ID" value="XM_025661753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYJ0"/>
    <dbReference type="GeneID" id="37165155"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH55922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="312" mass="34768" checksum="FF8D6548EF902957" modified="2022-01-19" version="1">MSSLAMHCLYVPLTNASPTPALNLLLTIPDHVVCLLRKVYEAGEEVQCMRKTDLKQALCLDAHLHTLGLSTEWRGVRAAAANMTILKDNTIADAVGQRVARMLLVLNYKEICGCPQSHCPRPRRAGEKRKAYMINCIVYACFSRDLFKSKCDVIHNFLRQGRLLWIISSIVGLGFVLIYSDELMSTIKNVSITHNGVNAIAISTLYMRPRMVALLYSLEPAVADLMSGKISKALYRVIQDETGILGLSALSCTNGVYQAHLDHQYSTGNWEPVDLALAVHKIKERLCSRFRGAYFSVDYDSLNKTSTVDINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYW5</accession>
    <name>A0A8G1QYW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_425625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513076.1">
        <property type="nucleotide sequence ID" value="XM_025658084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYW5"/>
    <dbReference type="GeneID" id="37161486"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
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        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
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        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="663" mass="72809" checksum="A3CA05923F1CF9BD" modified="2022-01-19" version="1">MRQGESTGITGTTTSQGQFQTPDKPPRVRPATETNAAKAALARTELPASTASTSRSWKRNSFPGLPDQPTLTQIDFVAPKSQYTGSDGDDDDLDYIDSKSRSRRRADPEVIQIDDDSDNDADYQPPSHLKPKPADIRGVKFERGAKNAAPKPKKRSSQGGGDLKQKRRKSGEGSNISKKDKEKAKGHKTLTQMDYVRRYLKIEPDDDVKLDYTYITPKKSDGQDSQHMRSRDPESFQQQDDRQSNSNGREAQKIKDEEGATLTTEATNDRGATEAPVTPKKRFKQEIPSSQSPESPGLAIITSSQFRGTTRSQNHVPVSIPDRRIKEESPTMHRIKEEPHQDLEPMLLFPNDILPELPESGNSDSPISRREGTPHQISADQAETPTKSARLHSSPGLLDSKEGAMPSQRTVIYETDAESDYGDLEDDLPDAPVSPKSPEPVEGDPDATDDLDFDPSKDNSQDQDLPLMDSSGLDVETELPLPEPNPTSEASIYYQRLQPATQFPLGTIPTLSSQKLAELFPEDSNDQQTLRTMSPLPSSPRTDSRAMSKPGIPAVSQTQAQNSAKAPMEMVPESSPIARQGNGTRAKEFIPPEPLARRDVVQVESSQPADRLHKKNQEESSGPRGILTGSQILTSSVMESVPLPAFLMDSQDSVGEPYSLPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ31</accession>
    <name>A0A8G1QZ31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_147353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511857.1">
        <property type="nucleotide sequence ID" value="XM_025654116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ31"/>
    <dbReference type="GeneID" id="37157518"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="2">
        <location>
            <begin position="36"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="334" mass="36715" checksum="ACAC63B9CFE89566" modified="2022-01-19" version="1">MPPPPLTVQYKEANGSKITTDIYLPPAPTTTTTENDTPKKYPVLINIHGGVFMLGHSRMVSMPQVDDCLARNWIVVVPNHRLCPQVNMLEGPITDIRDLLAWIYDGQLDAFLAGAGADAAGYRVDMDRVMAFGTSSGGTLALSLGYSVPRPVAAILDFYGAVHFTHPFWTQPLPDVQRTLPPLDPAFLHKIYDEYPVPTDSSISLEGQTELAGGSKAKGPDFSRPRDAFALTQVANGTVLQACYPDRDVREIDPVVHVGKGFPPTFIVHGDCDTKVSIEVSRELWRVLRENGVECGMVEVPGEDHTFAMGMQVGGRTWELQRQGVEFLERVISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ48</accession>
    <name>A0A8G1QZ48_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_478766</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514316.1">
        <property type="nucleotide sequence ID" value="XM_025662911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ48"/>
    <dbReference type="GeneID" id="37166313"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH56394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="508" mass="57675" checksum="C29AB5FA9B86B503" modified="2022-01-19" version="1">MFVYAWLGIALLTYHAFRSIYRLSFHPLRTIPGPKLAAITYGYEFYYNVIKGGKFVWEIERMHKIYGPIIRINPDEVHINDPDYYEEIYTSRARRREKDPFQVAQFDVDGAAFSSITPEIHRQRRAPLDKFFSKQAISNIEYFIYDSLDKVIKAYKEAYQSKSVVSLDAGFAGLTADIIHQYAFGFNPGNLDAEGFNESVRDAANAVLQGMHLLNFFPFIKVVFGLLPHGLLRLINEPAVKLAKEKEDLYARSAAALERNQTPVKEDEKVSNSKGAILDAIAAPRMPEHMRTPKRLMEEGLSLAIAGTETTARALSVGTYHLLTKEHVRLKLKEELKTVMPTPDMRVSRTELEKLPYLSGVINESMRLATGVSSRMTRIAPTEALVYKEHVIPPGSLFSSSNVFILMNPNIFPNPHDFDPERWIRAAEKGERLDRYLVNFSKGARICLGMQLAIAELFIVIASLMRHFDMELVDTPKETIEFARDFGAPYPEKGNLFIKARITGLAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ74</accession>
    <name>A0A8G1QZ74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HCP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_49928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514361.1">
        <property type="nucleotide sequence ID" value="XM_025664066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ74"/>
    <dbReference type="GeneID" id="37167468"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="366" mass="39803" checksum="982A2C83FF2EA3AB" modified="2022-01-19" version="1">MPLREILHKKDALNNTADHYASGAVPTTSGRNVPQITFIRTDTTSQEVIRPPVFDGDADHPDDRYLEPVPPSPSHRKSLNPFRRSRAPSESSGTSSPTRPRGERRLTHLLHLDRSGSRNSSSSSVNVPSDLPQINCDRGDEQEREAQWEKRATMLAQRSPQAGASCLSPTSPTGFGLDGAPSRSRSSSRSRINDPEGDINVQEAIRLHEAGELERSTKMFEHLADPNGANNALSQVLYGLALRHGWGCSPDPDRAVMYLSAAASNSASIESQALQAGIKKGGSAKGELVLAIFELGNCFRNGWGVKKDPVAARQYFETAANLGDTDAMNEVAWCYLEGFGGKKDKFTAAKYYRLAEEKGNKLVGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZG7</accession>
    <name>A0A8G1QZG7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_36443</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515173.1">
        <property type="nucleotide sequence ID" value="XM_025655699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZG7"/>
    <dbReference type="GeneID" id="37159101"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF22">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G11480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH57251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="280" mass="32161" checksum="E8CB92B03E95DE06" modified="2022-01-19" version="1">MAPGGGRDFNCTWEHCNKSFNRKSDLCRHYRIHTNERPYHCTVKDCNKSFIQRSALTVHSRTHTGEKPHVCDHRGCHKAFSDSSSLARHRRIHTGKRPYICQEPTFCRKTTLTKHQHRSHPPGSMTRLPSEDAVSEHSYQGPVAVPVPNEQYLLAQQPYYPHTPTPTHEFYPHQSLHITPVPIQEQPPIVTQHIPVTSPVDVQRAQQHYMQLVQQQQQQQQRYDPGRQGYLPPEFQQPYHTLPTAEGPPLMVTSTHSDYKPPARILNQPEGTDWGFLGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZH4</accession>
    <name>A0A8G1QZH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_51917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514415.1">
        <property type="nucleotide sequence ID" value="XM_025665025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZH4"/>
    <dbReference type="GeneID" id="37168427"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034672278" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="22952" checksum="811F0FF25C4EB06B" modified="2022-01-19" version="1">MRLQLTTSLALLATASTVVADDVISVLWPSSASGENYNAKLIGTTGGDLTTLVINCPATASASVTSSPAATAATTSAAVVKRATTASSSDDDDDDDFNDSCNIPDSGETLTVGSSTWAFSSSGNQFSQQATCSFTGTTVASCAFTYNIDTQTSSSSGVTTTQLNKVPITITSTASATGTATGGASTASATGDASGSSSSAASTGAATTTSDSGAFATGASQWVAGGAAMMVALAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZK7</accession>
    <name>A0A8G1QZK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_450564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514460.1">
        <property type="nucleotide sequence ID" value="XM_025660402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZK7"/>
    <dbReference type="GeneID" id="37163804"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="371" mass="40564" checksum="BF590EB7CB83293F" modified="2022-01-19" version="1">MVALIPPPEPRTLLPPLLACLPTAFVSPQPPPALLPLLSPILRQRVKILSSVSASPTESWLRLLCWDAGQAERLQTLVDGATFEPHPVSGEIELPDELPVRYMRVDEETLRSRVILPEFSLKVIYLWCPDDQEGGGPAWRVAELLPQEGNVDDGEDWSVSIGEANARQKDRLLEDALKAGEAADQAKNQKEEEEDDDDDYWAQYDATPGRTPANKTPAPNAVSSLQQSEADYFSRYGDVQPAMDNHDPEEDQPEVGPSSLNGDMLAKLLQRQFNGDEADKPNTSNGVATNGDHAGLNHPRPSSISSASSEAVARLEQEAENQSAYEVGVKQHIGSSIKGLFRLAKATGISRSDFQSLVKTELELLNVSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZT8</accession>
    <name>A0A8G1QZT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NRS/ER</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_471130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512262.1">
        <property type="nucleotide sequence ID" value="XM_025662450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZT8"/>
    <dbReference type="GeneID" id="37165852"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="263" mass="29750" checksum="73921A0F3312EEA6" modified="2022-01-19" version="1">MEGQAPTRFLLFGNELARVRPSHVINAAGKRGDPNVDWCESHREETIRSNILGAVNLADCCLIHDVHLTHLGSGCIYDYNEDHAWGGPGYTEEDEPNFTGSFYSNTKVLSERVLRHYSNVLILRIRNPIGADLHPKNMITKLASYKKLINVPNSGSILPSLIPAMILLARHNETGIYNFTNPGSFTHNEVMDLLKKHIWPELQWKNFTEEEQRKVLMAPRCNTSLDVGKLERKLSEYGYLLPTAHEAMEDAFIKIKQSGNLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0K9</accession>
    <name>A0A8G1R0K9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_451354</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513497.1">
        <property type="nucleotide sequence ID" value="XM_025660576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0K9"/>
    <dbReference type="GeneID" id="37163978"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000117">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="11">
        <location>
            <begin position="9"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="13">
        <location>
            <begin position="292"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="12">
        <location>
            <begin position="449"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH55575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="606" mass="67915" checksum="5E9B8A81454F44E9" modified="2022-01-19" version="1">MSSEAASQVSVGALSAIFDDTKPQTREPIVQCVQIKQLPSQQSHPERYRAVFSDISNYVQTMLATQLNPMVSSELLRKGCFVRLKSFQANSVKGKKILIILDLEVLEGLGVAEKIGEPKPLESKTDEDDKHQPTTISSNGFYGSKMSGAQVQSNTGVQSARPVLAAAHATIYPIEAISPYSHKWTIKARCTSKTNIKTWHNRNTEGRLFSVNLLDDSGEIRATGFNDQCDMLYDVFQEGGVYYISNCRVQIAKKQFTNLNNDYELTFERDTVVEKAEDQSDVPQVRFNFTSIGDLQSVEKDTTIDVIGVLKEDMGVSQITSKTTNKPYNKRELVMVDNTGFSVRLTIWGTTAQNFNALPESVIAFKGVKVSDFGGRSLSLLSSGSMAVDPDIEEAHKLKGWYDAQGRDENFSSHASLLGAASSTMKSDQFKTIAQIREEQLGMSEEAVYFSLKATVIYIKQDNMSFAYPACLSEKCNKKVTELDPGQWRCERCDKTHPRPDYRYIMHVNVSDHTGQLWLSCFDDVGKLMMDMSANQLMELFQTDEKAAGDAFQDANCRTWNFRCRAKIDHFGEQQRIRYQVSSANPINYSQEASRLADLIESYNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R125</accession>
    <name>A0A8G1R125_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Branched-chain amino acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_398899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514608.1">
        <property type="nucleotide sequence ID" value="XM_025657075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R125"/>
    <dbReference type="GeneID" id="37160477"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000010">
        <property type="entry name" value="Branched-chain amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="361" mass="39718" checksum="9F224A270002DB72" modified="2022-01-19" version="1">MTSFPPPPTQSLEWEKLGIAPMDVNAHVECEYSVFTGHWSEPRLVEDPLLRIHGLAPGLNYGQQAFEGMKAYRDPQGQINVFRPKDHAARLALSCSAVAIPTIPEELFLRSVNLAIAGNAEYVPPHDTDAALYIRPLVFGSDPFFAVSAGTGYKFCIYVQPYRAYHGSQPIPALILEDLDRAAPKGVGHVKVGGNYGPVLKWSDQARAEGYYITLHLDSRTNSEIDEFSTSGFIGLKKSGDSFTVVVPSSRSILKSVTSTTCLDLARSMGWNVEVRPIPYSELQYFDEVIAVGTAAMLVSIKSITRRSTEETFAYNTDGSGDGCKQLQQGLLDIQKGRVKSNEDWLWQVLPIEQEAGDKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R133</accession>
    <name>A0A8G1R133_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_451874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512907.1">
        <property type="nucleotide sequence ID" value="XM_025660691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R133"/>
    <dbReference type="GeneID" id="37164093"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF23">
        <property type="entry name" value="SORTING NEXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="100"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="516"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="573"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH54985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="679" mass="73537" checksum="E0623CA136FCB034" modified="2022-01-19" version="1">MTSDPLRPGLHPLSHLKAGPTTSSSKSTAVPSSPTLQSFAQTPTRPQPVKHASREDSVNATSDKATIALIRRVLCPQAGNHGGATTPQPPEDLLPPLTSSNEVDRQLYALIAIIVKEFVYTWYSKITSDQVLVNELLQVIAHCTRALEQRLREADVAQLFLDEIPALVERHITSYRLAKQQSEQSSISPPLRELYHALNPHPGLSPIPDPSDAQAVAQQRENESIYRQLLVHGMLAVLLPTEDLENASLRTLLGDILADLVLGNAVAGKISEGWFLWDSITKVVDRVGRNEQDEDAATATMRQRSRLHKYGLLSQEAFTEGHSSSQVQVPVPDWIWQALQYVYMIYVTLRFIVIGLFRVASAPPVTASLTPCPPTSNADGPPSCATSKKRPVLDYRLYGMVSQVMDVPQRMPWLCGMLALIQYLILAGPGKLGDTDSVLDRFLHETIRDHVLTPALFPNLLLATRAALFPLNARPASTAADGRAAASAPQLSVQPPASPIVKGSVNDAAGASDACSSVSSSGVSATAPLSPDPRPSTPDVASIKRRCAASILSRLPRPIARRFFGVPSFSIEHNPSSRRPGRLNSSDEPESPWLDSPQASSTVSPADCGHEESLLLAAVEEVLDLFADDYCNKHLIYSIIEAILTTLLPELSERSIAELMEDRGVPLASNLTPPTHAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1H5</accession>
    <name>A0A8G1R1H5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_448923</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515745.1">
        <property type="nucleotide sequence ID" value="XM_025660055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1H5"/>
    <dbReference type="GeneID" id="37163457"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.580:FF:000003">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016612">
        <property type="entry name" value="Mediator_Med6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013286">
        <property type="entry name" value="MED6_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="164"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="262"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR013286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH57823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="315" mass="34392" checksum="5439E25889DE1AE7" modified="2022-01-19" version="1">MEEILWRSPPHVQMMGGYLHSNNILYYFAESPFFDPTSNNASLAIQANYNEAFRHFVETREAFEGRLKTMQGLEFVVSYDPIQAAAQPDGRFAHEPSNIWVIRKQNRRKRTGLEDEVVVLSTYFIVGDCIYMAPSVASVVGNRILSAVTSLTSLLKTASTLPTFTPSHGHTYMPPALKQADASQPGTQSQQSKENTPLPDADAAGKASLVGSSQVVGTGSNVQDTRTLAESFNLLRRYGEEFMDEHPLVGEPGSFILSRVNDTDRTSAAKPPAPAAKVGTPQVRVDTPGKVSEKGATPSGSEENKMRKKKTKVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1M1</accession>
    <name>A0A8G1R1M1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative short chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_513484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515820.1">
        <property type="nucleotide sequence ID" value="XM_025664709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1M1"/>
    <dbReference type="GeneID" id="37168111"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF154">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_2G04560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH57898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="340" mass="38330" checksum="DC0C43EA39BFD088" modified="2022-01-19" version="1">MTGIFTYREFSLRDTPPLDGKVALVTGGHGGIGREITAQLLIHNIDRALVLGRNSDKFLAAKEEWQRRHINLGKDDKRVTFVQCDLGDIFAVKEAADQVRSITKRLDIIFCNGGLGVTTNYERSPQGVEMVFAANCVGHQELVTLLLPLLKRTANQHSESREARIVVTSSSLHSVCRTLDFNQLTTTTRVMPMHPYIDGFWRYCRSKLGNILFTRELARRIEQEGPNANNIYVNVFFPGNIVTEQWKAWDEYVGTTLGAVFRYVFSIIGQSTQDGAATAVYLATSDRIRVDGIRGQYYIPIAKPDATTDIGNDPVLARNLWDWIDTKVTEHLGLHWQQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R290</accession>
    <name>A0A8G1R290_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_451338</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513477.1">
        <property type="nucleotide sequence ID" value="XM_025660568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R290"/>
    <dbReference type="GeneID" id="37163970"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="11">
        <location>
            <begin position="69"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH55555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="344" mass="37219" checksum="B02613FB1B05535A" modified="2022-01-19" version="1">MGDSADNSTGPPPGESPVTATGLFIPPSIDHSQLFAGESYSYYSPCPPVIAASKVTESATSSSPNHLVLGVDEAGRGPVLGPMVYSAFYLPQDLHHSLLTRDYSFNDSKVLTPGVRANLMKLLCTPGNPLHESCGWAVKLLSARDISSGMMRPGAGAYNLNAQAMDATIELIREIIEDRNMDVREVYIDTIGNPATYQQKLEKIFPSLRITVAKKADSLYPCVSAASVAAKVTRDVALDLCHQAIYEDVHSEDASEAVVPQSWGSGYPSDSKCANWLKKNMDPIFGWGNECRFSWGTAKELLELKGRPKVDWPGEEEEITLLKLSTSYWNGTGQGPLGSSLSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2E6</accession>
    <name>A0A8G1R2E6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rho GTPase activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_449271</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516086.1">
        <property type="nucleotide sequence ID" value="XM_025660128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2E6"/>
    <dbReference type="GeneID" id="37163530"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07652">
        <property type="entry name" value="F-BAR_Rgd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000063">
        <property type="entry name" value="Rho GTPase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000041">
        <property type="entry name" value="Rho GTPase activator (Rgd1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF136">
        <property type="entry name" value="RHO GTPASE ACTIVATOR (RGD1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="6">
        <location>
            <begin position="37"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="480"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="378"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="138"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH58164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="673" mass="73641" checksum="D9CC8212080C67AE" modified="2022-01-19" version="1">MADSALHDSPAHDPDAPPSSAGSTGHPGALEPRPGPAPMSEELKGRLDKVVYSDIGVTTLLTRLKQSVSSAKDFSTFLKKRSSLEEEHAQGLRKLSRSLHDSAYRNENRQGTYSHNYNELNRFHDRMADHGLQFSVSLQQMADDLNELASTIEKGRKQWKQTGLSAEKRVLEAETSAEKAKAKYESLAEQYDRVKTGDKQGGKFGLKGHKSAAQHEEELLRKVQNADSDYASKVQAAQSARQELVSTLRPEAVKNIQKLIAECDSGLTLQLQKFATFNEKLLLGQGLAISPLKDGSANPALAPKSLYEVVSQIDNEKDFNEYVLSHERNPAAVTSDQIQYKRHPTLGGSSSGPVVPASQPTTQNKRQSMFLPQSFSQSNLLSSTPASSQPSAPAPVSAPAPAPAPAPALASPPATESLPYPQNPDSYSSPPFQPPYPTSRSEQHHLNQAPALPAKTPLGPTGNGFQPSPNLPPLKPVFGVSLDDLYTRDGTAVPMIVYQCFQAIELFGLDMEGIYRLSGSATHISHMKALFDNDSSQVDFTNPENFYHDVNSVAGLLKQFFRDLPDPLFTSHFYNDFINAARIDDDIQRRDSLHALVNNLPDAHYATLRALILHLNKIQEHYTQNRMNAGNIAICFGPTLMGANSGGNIADAGWQVRVIETILVNTFQIFDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3G8</accession>
    <name>A0A8G1R3G8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_372068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515491.1">
        <property type="nucleotide sequence ID" value="XM_025656021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3G8"/>
    <dbReference type="GeneID" id="37159423"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037504">
        <property type="entry name" value="PSI_induc_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018:SF1">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="420" mass="46146" checksum="D87F7B1151C4F883" modified="2022-01-19" version="1">MSPVDKAPVPLWARDVVSDLKSDASTFTSWDKCMSKAYCKWPVIVAIIIAALIVLSVIACVINCLCCGVQCCKCCCGCCFKCCPGFKRKRNKQKYLDDQYDQPPPMPAMPTMPAPMNNAYQTPYQPQAPPVYRGAEVARFDTPSSPANGKFDEDALPAMPTWEGAVTKKVEDENPHAESLEMKPLSNANQEPRRMPSGARSVTGGYGGPPPLRTGTPAAPGAYHAEPRGYDGYDGPDAYGYHAPGPRSPPPVSPYEHQPYSEYPHEDRFHNMSPAPTYTTQPQYMPMDATQPHHAPMDGMQPYQMPMDGMHPNYMPPEPAHPHYMPQHQMPPDTGTYGQPMPINRTFSPAPTLHSAMNAPRPVPYRQPSPGFQAPPYRNMSPATPTSPPPPFSTTPAPRDANEPGRPPSLLQSGRRPTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4G8</accession>
    <name>A0A8G1R4G8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_418079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516934.1">
        <property type="nucleotide sequence ID" value="XM_025657798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4G8"/>
    <dbReference type="GeneID" id="37161200"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH59012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="268" mass="28816" checksum="B6FC6D3420C623CF" modified="2022-01-19" version="1">MTLTTDYHSGKAYVLTGGCSGIGLAVLHYLLARSAIVHVLDISSTPPELPSHLSQKEKNLHFYPKIDVSSVHAVQKAFYQITTTTPTLHGLINNAGIAYQNVAFGFESDDLFNRVMDVNVRGVWNVGNAFLSHILPSEADQQFLPATAREGRGVIVNLCSTASFHANPGYVSYTVSKHAVLGMTKAWATSFAGQGVRVNGVAPGATETPLIDGTSFKGHMREQYLSQVPLGRRCAKAEEIADAVGFLLGKESSFMTGQVITVDGGRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5E4</accession>
    <name>A0A8G1R5E4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_32464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="80" mass="9733" checksum="F957456744DEA9C8" modified="2022-01-19" version="1">MIPVSVFPKQVNSSILFSLSFFIFSILFYFFFIFFFIFFIFIFFLFYFIFFLGLLFPVQVTKYLQQSFPAQSIVHCRLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5S5</accession>
    <name>A0A8G1R5S5_9EURO</name>
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            <fullName evidence="8">Efflux pump antibiotic resistance protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">BO85DRAFT_393489</name>
    </gene>
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        <name type="scientific">Aspergillus piperis CBS 112811</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="RAH59732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025656885.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
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    </dbReference>
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        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF41">
        <property type="entry name" value="MFS TRANSPORTER OF UNKOWN SPECIFICITY (AFU_ORTHOLOGUE AFUA_5G09940)-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="99"/>
        </location>
    </feature>
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            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="521"/>
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        </location>
    </feature>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RAH59732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="562" mass="60235" checksum="30D47E4D2AD3F079" modified="2022-01-19" version="1">MSLVQALHYEITTPAPSLSHPAVPSPLHSIPQTPADDTQDPLNGPLQQSVAPTAGQAVFERAPSVQITQSRRLAITVLLLLANLVQMTVSFAGIAGGTLLGESLGGQESSATWVGASYAMTQGTFVLMSGRLGDVYGHRELLLAGGAWLSLCTLISAFCNNFYAFVAMRALAGLGGAFIMPNAVAMIASTNPPGRMRNLSLGFFAASAPTGGYFGALFLGAFIEGTEWKWFFVFIAGIGIATLIPLWALSSREALLDRHGKIDWIGSALGTSSLILFNFVWNQAPSVGWSTPYEIALLTTSVILFGAFLIWEKSGTEYPIMPLEIFKAPSILTLLLVVLLNYMAVGTLIWYQVLWLQDVWHWSPLHFAVGWTPFVICATGAASLAAWLVPRFAAQWILAIGTITILISNVLMATVPVHQTYWAQVFPSIVLFSFCPDFVYTAAQIIASNSVRRHQQGIAGSLIGALNLYGVSLGLGFAATIEDQIAKHSGRLMGYRAALFFGVGISAVALLLDVCFVRMVKDDREGWNEEDRAADGTDADALELTGQAAATGAQWPAAVERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5V0</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">BO85DRAFT_270826</name>
    </gene>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
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                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
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                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58275.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="53" mass="6112" checksum="08ED1F0B92385812" modified="2022-01-19" version="1">MVRLGYFHCGSRGYGPVSLRYQKKHSGSPFVIVIVFPSLIFFVAHHLAYWVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6X6</accession>
    <name>A0A8G1R6X6_9EURO</name>
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        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
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                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
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        <property type="entry name" value="ARID_dom"/>
    </dbReference>
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        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="5">
        <location>
            <begin position="424"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="526"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="577"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH60317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1119" mass="122048" checksum="9F82A00FFA71D50E" modified="2022-01-19" version="1">MGPPTILAHPFYPLPDCYRPVLLLLLLAAAATYYRYCSVPYLYGALSPACCLSFSQIHFETPILPRSPCDLLIGLLPLSAARNAAANPHLIFCPFCGTSDLPWSRDLLDLLAISLSGLPTTAIRDRPPSAYGLVKPLDMNAWADPSNLPNHDNGAFHQATIDPSAAFLHTSPTPDPTQFQRMFNGVPRNASPGFHNPNQVIPSKRPRPEDAMSMSPRQAPGAIAASRSQTPHQVPFPGYQGAANGAPQYPPHPTPYQHLQQGASPNVTQSPIMQEFDQHGVQRMGTASPSPFSPAGPQVGSHMSPSQSDHPSRVNTPQNSSFMPNQPYPQAMAPQFPPAPAMTTAAVQAPMQAHYGGMPQGYQQAIAAQQQQQRMHAMQMQNQGRPMAMNPAMAGRPVAAGMNAMANPQQMAAIRQMQQTMAKPPNPEGFMRSLQKFMMSRNLPLDPSPVVCGRPINLVQLYATVMKLGGSKKITAANMWHVIAQQLQFPPMQLPMAMQELREHYQRNLAAYEQAFLSTQQKQFAEQMQQTAVPRQPSDPSAMHFQSPATKPGQGYDNAQQMGHPSPSPASVSSSVQHNASNGFATPTPVKTQGKPQNQHRLSISRQSQPPATPNDPTGQLPSQSPAQPGKAPGPVPVKPSEQLDQSDQPLKHQIEDPYKPMVLPESSFHGPIAIDEMYQIGEDISRLKPNVPSFAELGVIDIHALTMSIKSGIHAEMRMALDTLTSISSEPAIQISLDNCDDLVESLIECAEDQAEFLAEHAAEVSDMMLLSSYEEVTRGCQSEWTSLADVPEFGSLDYELDRAVDRLICITTILRNFSFIESNFGMLSTPPVVQFMSTIIRYLGTRNMLLRTHQNTLDFMKDTVTYLSNVAHTIQLPSKEEALCLLHFLLAFAPFPGPMSSEGIMFNSYNPAIHKYTPAAVDSLAKLLARDEPNRTFFRAIFSGDGASIQQELLTRAFGLAICPVPDQPRKPLAIADARKVFLMQGLLAADILSGFADGPIAKSWLESTDGFAIHLLRLSCLLSTERVPPPSTNSRQSHAARGQAEAEAAAYSSIINRGLAILRRLAEKSKLADSNATLRFPSGIIPRKESLLGALLMPNIDPGVVRQLITYARLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6Y2</accession>
    <name>A0A8G1R6Y2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_446980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518345.1">
        <property type="nucleotide sequence ID" value="XM_025659621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6Y2"/>
    <dbReference type="GeneID" id="37163023"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH60423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="143" mass="16954" checksum="6AC72B106B56D353" modified="2022-01-19" version="1">MGSVVLPHLRTAWHVDQAILSEEDRLVVIRFGRDHDVDCMRQDEVLFKIAERVKNFAVIYLCDIDEVPEFNTMYELFDPMTIMFFYRNKHMMCDFGTGNNNKLNWVLEDKQEMIDIIETIYKGAKKGRGLVVSPKDYSTRYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R763</accession>
    <name>A0A8G1R763_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_435635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519283.1">
        <property type="nucleotide sequence ID" value="XM_025658537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R763"/>
    <dbReference type="GeneID" id="37161939"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH61361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30936" checksum="23A516A12B13BAC0" modified="2022-01-19" version="1">MPSSDSAYTPSSSSPASFHLADGLGSALQQNHRSVIRLNLQHFLWRQVFGYSIHPSIPTTPTSLQECDRCSLWHGPLADRCGPKVPHSGWLPSNIHLDRWDLFTPVPQQLQEQYDLVHVRLLVLILSGLDPIPVIQRFFQLVKPGGYLQWDELDCANLCIKKVDPSIAAPALEEIRVVSHADGRHDWALELPRLLAEVGFQKVTIDHYDEPPEMVRAFNDLHLLTMEEFATRLAGQTQHKAAMRFTQLIQAGYQESVNGVALSFPRVVVVAKQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7L1</accession>
    <name>A0A8G1R7L1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_265292</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517127.1">
        <property type="nucleotide sequence ID" value="XM_025655047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7L1"/>
    <dbReference type="GeneID" id="37158449"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH59205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="291" mass="31399" checksum="747A9AFE4ABE2A96" modified="2022-01-19" version="1">MAAIPPQSQDPYRMAPPPGSYRPPDMYSAPPPPQVVYQAAAPRQRTAIACRYCRRRKIRCSGFESSQDGRCSNCIRFNQECMFTPVSSQAQAFVPAHAAYPHLRNAQNQGRGPPPGGVMLYGAHGQPLPPQQQPESTLPSVYPPQYANAPPLPNGAQDHRPVGRRGSGSGFEYPDPTNLAPVTPATSASGYQTYSATSPYYPPPPQHERRTSPQSNYPYDGRHSSSPHSSPYPPVNPNQTPPPTSTPGGSTRGGLNVRDMLNPGEGQNQGQGRSSTDSDMLNALNRRGLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7U0</accession>
    <name>A0A8G1R7U0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_189497</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="4"/>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519090.1">
        <property type="nucleotide sequence ID" value="XM_025654421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7U0"/>
    <dbReference type="GeneID" id="37157823"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH61168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="345" mass="39007" checksum="F4CCA2C514E8B472" modified="2022-01-19" version="1">MDRHNLEAQLGTIKVPIVHIPWAGDSADVLLLEASMLDWADQKGLLVDVAYRERVKRSRYAWLAARCHPKAAPELLSVISKFFVWLFVVDDLFLDRVDIVTPNTLSNLTAIINVVNFNCARPEPVYGELALLDICQSLRQLLSAEHFERFAQGIKLWATTAGLGILYHLQERPVGVSQYESIRRHTSGVESCLALADASNCGPISSDEFYRLNVQELRRYTNNIVCLANDIHSSIVESRQPGHFWNMVHIRAADGYTLQESLDHTVASVYEELERFQKLEHHILQDATPQLCGLVNGCKQWIRGYVDWVALDTKRYQAAYAVGDADDRNVLHARHMRALFATPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7U9</accession>
    <name>A0A8G1R7U9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_219879</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518024.1">
        <property type="nucleotide sequence ID" value="XM_025654680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7U9"/>
    <dbReference type="GeneID" id="37158082"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044836">
        <property type="entry name" value="TOL_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45898:SF4">
        <property type="entry name" value="TARGET OF MYB PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45898">
        <property type="entry name" value="TOM1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAT" evidence="4">
        <location>
            <begin position="227"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="420"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="321"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH60102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="457" mass="49894" checksum="C354A431D0CD1B37" modified="2022-01-19" version="1">MKRLFNSFSRRSSPARDSPSYPEDSPEGIILREVTAFCESGPNSANGDEFVHLPAIVESAESSPNAAREAALRISKLLSNPAKARSNVQYNAIMLMRILIDNPGHTFSRNIDAKFVATVKDLFRNGRDMNVHSFLRDTLDSLEMQRAWDEDLALLLGMWSKEKEKYAPKNTGNVCVQTSPITRSKHRQANLMIPLQPGLTQPLVQPYRQTPNYFNNAPNQNQHGGLPQPEELSARISEAKTSAKLLIQFVQSTPPAEMLENELIKEFSDRCRTASRFIQNYIHATNPAPDEDTLVTLIEANDELSVALSKHQHALLQARRAQGQSGSQSPASSSQASSSGAVQPPAPAAAAGGASAPPVPPRNQTQSPLSSGSSSTAPVLPRTYSNGAGRFEYRSEDFQVQNPFADTSAPAAATGTVPVAPAVYGDQQQARAEGSSPDWWAEGQQQQQQQRPVQQHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R841</accession>
    <name>A0A8G1R841_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA hydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_446093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518869.1">
        <property type="nucleotide sequence ID" value="XM_025659424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R841"/>
    <dbReference type="GeneID" id="37162826"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128:SF1">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH60947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="35877" checksum="852900F720216A8A" modified="2022-01-19" version="1">MPGVLTQTLAVSDGPLTSENAALLRPSDPNLPLDELRARFNADGYLFLKGVLPREDVLEARRQYFSYLAPTGVLKTDSDPVHGIFNPDKTPDDFPGIGAGAAGGNGRPGGESAAQFVDRAIEAHYKDWYAEKLVQHPALYAFIAKFTGWGDNTLTFKRTLLRNNIPQTKPIGVHYDQIFIRHGEPTAVTAWVPIGDIKLSGGGLIYLEDSDVVGQKIENEFTAKALAAGMTEEEAKYAFNSNMMSTGMLSENPAEFAKENGRRWLVAEYEAGDVVLHKPHMIHASTVNNDPDRVIRLATDLRFADSSRPYDKRWMNFYRFNDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8K1</accession>
    <name>A0A8G1R8K1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAR-17a/AIG1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_412949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519973.1">
        <property type="nucleotide sequence ID" value="XM_025657588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8K1"/>
    <dbReference type="GeneID" id="37160990"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF1">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32917" checksum="E8203677CD97BD87" modified="2022-01-19" version="1">MLNRLRNRSLYDLLHVDPSRDRAHVYETSWLLPPLPYAILRGTISLYIFTSIFFIWGWSGTHGDRAEIGESFSYFTWLTYWGIGFYMLFASIHTACYALKGHSVLFDRWPRALRALHGLFYTTVTTYPFLVTVVFWGILYSGPWYTVTFSGWQNISQHGLNSLYALSEIILPTTAPHPFLSLTVLIFILLLYVSLAYLTYHTEGFYTYSFLDPGPHGEKSGHVAGYCFAILAIIVVFFLFSWSAIWLRRRATGGKVKRSVYDRDYAGAGMGGDVEEEVGVEELREEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8T7</accession>
    <name>A0A8G1R8T7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="7">3.4.21.92</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_447298</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="7"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518643.1">
        <property type="nucleotide sequence ID" value="XM_025659692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8T7"/>
    <dbReference type="GeneID" id="37163094"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000001">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001368">
        <property type="entry name" value="PRK00277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009205">
        <property type="entry name" value="PRK12553.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH60721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="252" mass="27429" checksum="B39B8780E2C1F235" modified="2022-01-19" version="1">MNTTRPIQRLARVVSLQTVKPALLSRSFASSVPTLSGARSPRGWTPTPFVTETVGGGWHTYDIFSRLLKERIICLNGEVDETMSASIVAQLLFLEADNPQKPIHLYINSPGGSVTAGLAIYDTMTYIASPVSTICVGQAASMGSLLLCGGHPGKRFCLPHSSIMMHQPSGGYFGQASDIAIHAKEILRVRSQLNKIYKRHLTGKKEMTLDEIEKLMERDYFMGAKEALDMGIVDEILDRRGPPGAEGGEAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA92</accession>
    <name>A0A8G1RA92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L35Ae</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_447315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518657.1">
        <property type="nucleotide sequence ID" value="XM_025659698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA92"/>
    <dbReference type="GeneID" id="37163100"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018266">
        <property type="entry name" value="Ribosomal_eL33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01105">
        <property type="entry name" value="RIBOSOMAL_L35AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH60735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="109" mass="12380" checksum="C37D061AA74FDB9D" modified="2022-01-19" version="1">MPSEQGHRLYVKGRHVSYQRSKRTVNPNTSLIKIDGVESTEAANFYLGKKVAFVYRAKREVRGSNIRVIWGKVTRPHGNSGVVRAQFRHNLPPKTFGATVRVMLYPSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAT1</accession>
    <name>A0A8G1RAT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_444113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520695.1">
        <property type="nucleotide sequence ID" value="XM_025658941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAT1"/>
    <dbReference type="GeneID" id="37162343"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18332" checksum="62B5B6CC837291FB" modified="2022-01-19" version="1">MLRYLLLIRATIRPEALFVQPLGHKAEEQLTFRGPSKRKFKALDQIVDYTDVLLELSQHDTQVARLNKEPFREAMQNEHVECVQVFIDLFTNDDRHRAAICTHLLSLTLPHVELLTYFLSQGADPDTRHFDTGEILLHRAAARGDESALRAILSSGSQVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAZ5</accession>
    <name>A0A8G1RAZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peroxisomal membrane protein Pmp47</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_443889</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520475.1">
        <property type="nucleotide sequence ID" value="XM_025658891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAZ5"/>
    <dbReference type="GeneID" id="37162293"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000134">
        <property type="entry name" value="Peroxisomal membrane protein PMP47B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="122"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="230"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH62553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="328" mass="36249" checksum="97C5FC361FE30305" modified="2022-01-19" version="1">MSQSNIEGQKKAIAVSAAVQQSDNMAHALAGAGGGILSMLLTYPLITLSTRAQVESKRAHSTTYDAIRRIIQREGVSGLYSGLESALFGISVTNFVYYYWYEWTRSAFEKAAARAGRSSKKLTTAESMIAGAIAGSATVLITNPIWVVNTRMTARKSESEQETLPGTPPKKSRASTISTLLDLLRQEGPKALFAGVLPALILVINPILQYTIFEQLKNIVERRRRMTPKDAFYLGALGKILATSITYPYITVKSRMHVASKDGPKESLNGSLKRIVKEEGFVGLYRGIVLTMGEPCKLMLISYDRHWAKGHTERHYRSFLVWVQGRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBB0</accession>
    <name>A0A8G1RBB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_445032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519511.1">
        <property type="nucleotide sequence ID" value="XM_025659167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBB0"/>
    <dbReference type="GeneID" id="37162569"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="104" mass="12205" checksum="8B013373C938868F" modified="2022-01-19" version="1">MYSPQEGKKQSCNIPKPGMSHNNDQDKQARKIKRRNKERNDSTRPDPSVIQANLAAVSQITHYTITIMITAKLLFVWCWWLLSIHFYPRPKVYYCFSSIYLQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBE0</accession>
    <name>A0A8G1RBE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_501748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520008.1">
        <property type="nucleotide sequence ID" value="XM_025664178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBE0"/>
    <dbReference type="GeneID" id="37167580"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="466" mass="51736" checksum="5A046339C35AD260" modified="2022-01-19" version="1">MPTQKCSKRRHTEDDSSHCSLETSVLGYKTPIWRTGLPAYAVCSCGGELWGREDVHELNQAAVLGHTLLHHGTEGGCAACIKTGVIFMFRAWLLSSSEDRELIALSLVAACGCVSRQYLLSTSQNAITRDLAMECPGLCRQRTLKWCHGMMPNKAFDMLAGVEGDLNSSFRKGLTVSRCSYACSVMTGPGQATDRPVRQTKGASFEAYLRERLADGFWYPMKAAVRSPDADRLYLTRYSTEIHEYAIDSACAFDTLGHARALQEDALYGVCSYDRQPLNQLPDSRSDSYDDIIYAAGYLALASYVWGANAHLDLLRGQVNQTSATPLPEHWHPRIWHDTLFRQSTTRELYKLTARTKDHASFTGDREFTECQSDCSCPERYHKYGLGATLFWARETWCVVSCPSAPFDMWIFGSFVDGVRAILRCGEGKHTPAPERNVSAALPVRKACIGGIAQSLNFAKKSVLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBK0</accession>
    <name>A0A8G1RBK0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_445454</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="14"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519959.1">
        <property type="nucleotide sequence ID" value="XM_025659264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBK0"/>
    <dbReference type="GeneID" id="37162666"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18801">
        <property type="entry name" value="SF2_C_FANCM_Hef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.20">
        <property type="entry name" value="hef helicase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="340"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="699"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="11"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="132"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="851"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1026"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="864"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="886"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="906"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="918"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1060"/>
            <end position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH62037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1132" mass="126521" checksum="299B56ED9B3F4628" modified="2022-01-19" version="1">MHLGFAMFSLDSGSSDYFDDDLGDLGVDRPSNAADSTDPDTPRPAKRRRLKASKDTPNAELQSHQKSRAERRDGARTALSSDSFIDYDDDEVPSPERESHYFQDDSEREARSKYKVFAPKNANFQENIFVTQLTQPPSPPEILRGPRWKKPDPGLPSRTAATPLPITTQTRDSATDGDGNDEYDDDEEMKAAIEASLQSFEEETSRPAPSVPLQKPPCPSAPPIVGQQNTTVVASNDLLDDIPDDAFDSDLSMSPPPAPQPRLAAQSFTQSTNRPLGVRQTTLFGMVARHPENQPPRGEQVYSPPEKSEPPTQHKLNQEALGTWVYPTNLGKTRDYQFNIAQKGLFHNLLVALPTGLGKTFIAATIMLNWFRWTKDAQIVFVAPTKPLVAQQISACFEVAGIPRSQTTMLTGEAAPGIRAEEWKAKRVFFMTPQTLINDLKTGIADPKRIVLVVVDEAHRATGGYAYVEVVKFLRRYNQSFRVLALTATPGSTVESVQAVIDGLDISRVEIRTEQSLDIREYVHSKDTEVQTFQNSEEMVLCMDLMSKALQPLLDQLRSTNAYWGRDPMGLTAYGLTKARQQWMLSDSGRNAHFGVKAKMNAIFTVLASLAHGIDLLKYHGITPFYRHLLHFQSNTEGQKGGKYQRQVVQDESYKKLMNHLQPWTKNPEFIGHPKLEYLKQVVLNHFMDAGEGSGADENKDQAATRVMIFVHFRDSAEEVTRVLKRYEPMIRPHVFVGQSSAKGSEGMGQKTQLDIVQKFKKGTYNTIVATSIGEEGLDIGEVDLIVCYDSSASPIRMLQRMGRTGRKRAGKITLLLMQGKEEESYIKAKDNYEKMQQMIASGTRFTFHDDMSPRILPPGVRPVADKRAIDIPEENTVRDLPEPKRRGRAPKRPPKKFHMPDNVETGFTTASNLAGTSKRKAPNKSKARTPTPEPVELPALEDVLLTPAQQKELELLYSNAGPSEELLVSYPRSDAFPRLQLAPRPTKAVRHGSLTRRMIQTLQKMDQITPNYGDRYKEIIAREAASRPEASIVAPKSNGHGEVHSRTKPRRTSKVVSSKPKDHEERDVSEVQRTPPAKHSVSATNAEVEPFYCSQRTQDGDTDDDFDLPDVSTLLDRSVERPPKRGRFVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBV6</accession>
    <name>A0A8G1RBV6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_362397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520124.1">
        <property type="nucleotide sequence ID" value="XM_025655629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBV6"/>
    <dbReference type="GeneID" id="37159031"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="367" mass="42571" checksum="E03A89DE63601101" modified="2022-01-19" version="1">MHRTVVPRQSSAHRFATLALYRALLRQCAKLPHYPSELAACKPYIQNRFNRYKTLQSPSQTANSLRAGYEALDLLYSASQGDQNGVQRIKKLISESEAAKRQKSEWHRERAKVIPVKPVSRKELKKEANKRYRVLTAKRHPDATSILARPRPVVNGKRRVPVLVNARGFPFLLIKKPQPKFLSAVLDSKLKRRWKRMERLKRLESELPMARDEDEWDLLTGHKEDAKWAGPIRVSLKEVQGQISEGDRRTKELAQAMWKVVLEERKLAEQEEKQRVEQAGEQPAVEKGNPSAEEHDKKRPNYPVQHFILMGPKPSHPPRYQNGAILPRPFFMSIMTGQRYYQQSAFGDKKYGRYMCIVQQWLAHVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC29</accession>
    <name>A0A8G1RC29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_24003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521366.1">
        <property type="nucleotide sequence ID" value="XM_025654832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC29"/>
    <dbReference type="GeneID" id="37158234"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="73" mass="8481" checksum="5ADCF061A7D72E20" modified="2022-01-19" version="1">MYGIVKSIVFFTLSSHSHTFPFQKIGKGKSCPGREKIEVKKIIENNTKRQLNIKDNYLSFSFPFSKQKNQQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD57</accession>
    <name>A0A8G1RD57_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_473636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520923.1">
        <property type="nucleotide sequence ID" value="XM_025662631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD57"/>
    <dbReference type="GeneID" id="37166033"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="351" mass="41176" checksum="C79655AA1B177B5A" modified="2022-01-19" version="1">MAYRQRRFSMFLRRPFKETTQNTSVPHPDLFKTLGIASNDTQRGNVDLPTIGECAVHLELLEVFRNLRIQIIQSKELVRVYRLDSSRLWISKHRRETKRTEKWHRFVSLAVERFQVWIRAAEKQLERDGNNETLILPPADILMVWHAFLLNPSDYKEFCTSRQLDRIQEMPFPWVVIHDCINPNNWSYTLPSPNKQWLESTASITADPLVSLTDTISETQSTPDIPNQEKHPSIPQENNALLHNVLRQMKFIDQMHDCLWISYPDAADILETARKRYNNFVELFRLHPGVMLVPTLDIDLVWHTHLCSAARYREFMMERVGRFINHDDKLGKGALDDGFDRTKELDSGLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD90</accession>
    <name>A0A8G1RD90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_410631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520983.1">
        <property type="nucleotide sequence ID" value="XM_025657488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD90"/>
    <dbReference type="GeneID" id="37160890"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="211" mass="23279" checksum="1A1571B562D295CB" modified="2022-01-19" version="1">MIHAPQKYHHHQHPSHEHSPPLPPTTTNILGTWYITRSSSPFWSDKRNPTITLTADTTTTTTPPGTLPLSALSQATTTSPAPILTNKTSYQTLSSSSVKTTTGTDRAISGGKEHGPIQMEWRGSGWLRMVSAQWEILGWGGADDDDKWLLVFANKSMFTPAGISLYSRTKTGVDEMVWAGIEGELRGLVERYPAEGELRELVMGMEVVRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDF4</accession>
    <name>A0A8G1RDF4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_386921</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520949.1">
        <property type="nucleotide sequence ID" value="XM_025656647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDF4"/>
    <dbReference type="GeneID" id="37160049"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000095">
        <property type="entry name" value="Mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="70"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="165"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="269"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="300"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH63027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="422" mass="45864" checksum="6EE2427236CC8607" modified="2022-01-19" version="1">MSLTSRVLGLFTTTETPSTDPPSPASASQFPNVAPASSDHVFHSAGPISASSDHNAQKATSLADEEEPRPPYLHAMLAGGTGGTCGDMLMHSLDTVKTRQQGDPHFPPKYTSMTSSYATIYRQEGFFRGLYGGVTPALFGSFPGTVIFFGVYEFTKRKMIDSGINPNIAYLSGGFFADLAASIVYVPSEVLKTRLQLQGRHNNPHFNSGYNYRSTTDALRTIVRQEGFSALFYGYRATIYRDLPFSALQFAFYEQEQRLAKEWVGSRDIGLPLEIMTAVTAGGMAGVMTCPMDVVKTRIQTQQNPESLSSTKSAGEPASTKESPRQHTSSHTTSTLRTHSRPISTSGASTSVAPPGAPRLDTSSFFTGLKMIYQTEGIAGWFRGVGPRGVWTSIQSGTMLVMYQYLLKKLEAYQGVDDLSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDJ0</accession>
    <name>A0A8G1RDJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_387329</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521148.1">
        <property type="nucleotide sequence ID" value="XM_025656669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDJ0"/>
    <dbReference type="GeneID" id="37160071"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307:SF11">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25788">
        <property type="entry name" value="Ig_Rha78A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial alpha-L-rhamnosidase N-terminal" evidence="5">
        <location>
            <begin position="174"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase concanavalin-like" evidence="4">
        <location>
            <begin position="362"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="6">
        <location>
            <begin position="475"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="7">
        <location>
            <begin position="816"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH63226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="915" mass="103974" checksum="FD984D5ECDF5CE09" modified="2022-01-19" version="1">MQITRCGIHGFHEVLGIDVDEIRFYWTIETDDKHASQLAYRVVLSTDETAVQGDATDQAKLAWDSGRVMSNEQRNIICRPDNGFQSTCSYYWKVTVWDQSQRPHHSAANHFFTAYPRSHLLPPYSMNQTYMPHTSLIFRSWFEDEPNRWKAVWIGDGGDKPIYLRKAFDLVQPPTRAILFASGLGHFNMTVNGAPASDHRLDPGWTNYHRRVQFTAYDVTAQLQTGANVLGAHLGNGFYAGEKGDGRFFWPMYEDNTYVRYGNELCFFGELHLFYSDGTHTTMISDPSWRVRKSATSLANIYASENHDRRQYPTGWDSPYFDDADWALAKPLTGPRGHIYYQTQPPVVLHETFQPVKVTEPRSGMVCYDLGQNASTMVHMEVEGPRGSEIIVRYSETVKEDGTVLMPDPLFKEFETGVYSRILLAGTSAPEAWEPDFSFTSARYIQVEGVSLDGSDGRPVIRSVVGRHVSSAARRLGTMQTDKEDVNQLLNALSWTFSSNLFSYHTDCPQIEKFGWLEVTHLLAPATQYIRDMEALYTKILDDILDAQEPSGLVPTMAPEIRYMCGPLHDTITWGCAVCLLPDILREYYGSTHVVAKVFPAAVRYMEYMRTKERRGGLIEHGLGDWGRGIAFGNNQANIETAIYYRCLQCVAMMARELGETQKAEEFEQWAARIYAVYNRHLLVTDDASRPYAYYTSLDNYPERDRDAIAQAMALQFGLVPEQYRKDVMAAFLDDVADGRMRAGEIGLRFLFNTLADAKRPDLVLQMARQEEHPSYMRFLRRGETTLLEFWQDECRSKCHDMLGTIYEWFYAAVLGLKPTGPAYRTFVVDPPYDAEFDHVNGSVDCPYGKIGIEFTRNQQGQTTVNVSVPFGTTATVKLPRSGKSSAYCREGEERRDVVGGEVSLSHGVYSIFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RE06</accession>
    <name>A0A8G1RE06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_473403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520622.1">
        <property type="nucleotide sequence ID" value="XM_025662622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RE06"/>
    <dbReference type="GeneID" id="37166024"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="388" mass="44925" checksum="00A45AED37F6AFDB" modified="2022-01-19" version="1">MDRYIRWKETNRLPDTPPLVLELDGSPTLWTENGKLTYSFTITLRRVIDSQQFWFYWDPFIDPKGNIKKISIEEHSRHLSSLPRIYQFPDEPESYYVEEAKKNWDRSTINVRESLPDTWTTLLEPGHIYTLLWTGQEIPYWDWGTAQQKIEMKTKHLPILVAGGAHLTFTVQEGRRPPIPSPPTPPPISPSERVDGAPVMSLELSCSSTMPLYGMLDLSIRVVYHGPSSDNESPQPITFHTWAFNPFDAFRVYRRLRPSQSDMETENEWKRSVDDRSPHVFWDNPDRVLNVAENPEGRFVTLFPGESWSKSWSFDLPDDLRPGEQVRYQFVGITLDWWDWGTAEDHAQTIVTLPGSGIEPISHPKNNDNRSKVVIPASNIVEWTMTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VH21</accession>
    <name>A0A8G1VH21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_524574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510097.1">
        <property type="nucleotide sequence ID" value="XM_025665424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VH21"/>
    <dbReference type="GeneID" id="37168826"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034591675" evidence="1">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="246" mass="27178" checksum="07EA51F8FFE63A32" modified="2022-01-19" version="1">MNLTLILALLATLAASIPADSPSFTDIYNPQCYKDTDCGTGCCYNGLCLAYCLHNEDDVHTELVRSFIDESNLHTEEDMDITAPNLLANRPGAIAGLVRVDVAGRGFYGYDLDGDVDFDVGFDVYDDDSLEVYDDSDDVAPAPEMHKRYSMPDIDLLPTSTDIIHTDGMCSKRTCKGCCWQNVCMAKCPRGEQDEVVNDGDEESEETSLDLVDWNLPQVVCSRTAPCKIGCCWHGLCWGLCRWKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VH45</accession>
    <name>A0A8G1VH45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_217682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825092">
        <property type="protein sequence ID" value="RAH51862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509784.1">
        <property type="nucleotide sequence ID" value="XM_025654658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VH45"/>
    <dbReference type="GeneID" id="37158060"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH51862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="63" mass="6946" checksum="802E3F416D85A4E7" modified="2022-01-19" version="1">MSSSRHSDTTGLGWVDGTGLGHPLHSNQHTPKLDWPRLGGWDGPGKPRHTTRHSRPNTQTRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VH63</accession>
    <name>A0A8G1VH63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_406474</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH52999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510921.1">
        <property type="nucleotide sequence ID" value="XM_025657336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VH63"/>
    <dbReference type="GeneID" id="37160738"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07106">
        <property type="entry name" value="ALDH_AldA-AAD23400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000032">
        <property type="entry name" value="Probable aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044086">
        <property type="entry name" value="LUC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH52999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="473" mass="51975" checksum="CCE3107755448B39" modified="2022-01-19" version="1">MALDYTTFYNVIDNELTSTSQTRHGINPANCQPNPEVPVSTAEDLDRAVGAASRAFRQWSRTSYDERRTAIHSFADRIAANKEDLVGLLSREQGKSLSQASTELDMAIQWTRSLSSIIIPKTVVNDTDDREVIQRYIPIGVAAAIVPWNFPVLLAIGKIVPAVYTGNTIIVKPSPYTPYCGLKLAELATQCFPPGVVQALSGGDDLGPMITEHPGIQKISFTGSIATGQRVMASCAKTLKKVTLELGGNDPCIVCEDVDIDAIIPQIAFLSFLCSSQICMMIKRLYVHEKIYDEFRDKLVQHVQALKMGEGTEPDVFIGPLQNKMQYDKATDLLNNIHSSGLSTFSSNPILGRTGYFITPTIVDNPPETSRVVQEEPFAPILPLMKWSDETDVLARANNTDYGLGASVWSRDLQRARRMADHLEAGSVWVNSHFDCAPFAPFGGHKKSGLGVEWGLNGLTGWCNSQTLWLPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHM4</accession>
    <name>A0A8G1VHM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_453694</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510712.1">
        <property type="nucleotide sequence ID" value="XM_025661110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHM4"/>
    <dbReference type="GeneID" id="37164512"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH52790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="318" mass="34022" checksum="EDE093DF1079D32B" modified="2022-01-19" version="1">MPKGRPPASRAVTVSKALSLLLRHAAEKEGLPIDAQGYANVSDVLAWRKLKSLKVTFPEIVDAVANSDKKRFALLYTPSTTQPTPTATEPTTTSTSTDPSSTETKPESQESTDTTTTTTALAATTTDPNPSHYLIRATQGHSIKTVEAAHLLEKLSLSDKDKLPRTVVHGTFHSAWPAIFSSGGLRCMGRNQVHFATGPAVEDVLAGNAVAAPGQVISGMRRDAQVLIYVDLEKALSAGCPFWRSENGVVLSEGLAVNKDGDGNEGEKVVPLEFVDVVVERKMGKIWERGQVVQEWPSEWAQKGGKKRGGGPTGGNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHZ2</accession>
    <name>A0A8G1VHZ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha,alpha-trehalose-phosphate synthase subunit Tps2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_471504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511763.1">
        <property type="nucleotide sequence ID" value="XM_025662477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHZ2"/>
    <dbReference type="GeneID" id="37165879"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000003">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000131">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH53841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="946" mass="105873" checksum="F968A80E33320E39" modified="2022-01-19" version="1">MAAEQRSAAMPDGQPNPGPIGSGLNVLGEDAFVNASNATPDLRGEQTQPSTLPDAPSYFSDTPGNHASSVPPAVTSPITPSQAVKDAKSGPELLRRLSLIESPIMLDADPREQYPSLRLTGRVISAAFCIPYKLYLHPGSDWELKPRPGTSALFDSMAYLGSNESKWSHTLVGWTGEVEPVQETAIPLQQIPINTSAKVPTTLNGSALPLNKAAAPVPVDASQRLPSHPLLDGFEVDLEDRERLDKQLSSSRYGKIVPVWLTGESEHPDDTVFLDDQGRWRRYAERELYPLLHYKQHGPTDGKSERKWWADYVRMNRLFADRIAQEYKEGDIVWIHDYHLFLVPSMLRQRIPNIYIGFFLHAPFPSSEFMRCLAKRKEVLTGVLGANMIGFQTFSYSRHFSSCCTRVLGFDSNSAGVDAYGAHVAVDVFPIGIDTKTIQKAAFGSAEIEKAVLGIRKLYAGKKIIVGRDRLDSVRGVAQKLQSFEVFLERYPEWRDKVVLIQVTSPTSVDEQKEENKIASQVSNLVSTINGRFGSLSFAPVKYYPQYLSPHEYFALLRVADVGLITTVRDGMNTTSLEYIICQQNNYGPLILSEFSGTAGTLSNAIHINPWDTVGVAGAINKALTMSPEEKMSQHQKLYKHVTANTVSSWSKQFVTRLLTNLSSFDQSVATPALDRAKLVRQYRRARKRLFMFDYDGTLTPIVKDPQAAIPSDRVLRTIKTLAADPRNAVWIISGRDQAFLDEWMGHIPELGLSAEHGCFIRKPHSDDWENLAERSNMGWQKEVMDTFQHFTERTQGSFIERKRVALTWHYRRADPEYGAFQARECRKQLEDTVGKRWEVEVMAGKANLEVRPTFVNKGFIAARLVNEYGTGPGQAPEFIFCSGDDFTDEDMFRALQKFDLPQDHVYSVTVGASSKQTAASWHLLEPADVIETISMLNNSSCSQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VI19</accession>
    <name>A0A8G1VI19_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_428687</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511911.1">
        <property type="nucleotide sequence ID" value="XM_025658213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VI19"/>
    <dbReference type="GeneID" id="37161615"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="170"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="342" mass="38717" checksum="DDCB3BDA1C382274" modified="2022-01-19" version="1">MAITEPILVAESLPTIELDLLRADNETENKRLLSVCQNYGFFYLNMTSDPELCQLWEDMLSIMKEYFEQPLDIKMQDARNDDNFGYEPMGTEEGPKPKTRDGYESLKFSRREYLKNSTDLTTSIRTKSTPFFNFINQAHTITLLILSRLSTQLGLTGSSRFETYHADPGPSTSTLGILRYPKHESGISEPTSVGHNQHTDVGTLTFLLAAQWGLQYCSPQTKRWEFIEPRAGHAIINVGDSLRFPSGGELASVVHRVVPLKETQEEDRYSIAYFLRPNDDVTFRDATGKMWSAKEWHDFKFDVFKSPSTLDAKGRFLTGMMLEEERGRWVGVAGEGGVAVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ51</accession>
    <name>A0A8G1VJ51_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Erythromycin esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_426600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512978.1">
        <property type="nucleotide sequence ID" value="XM_025658121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ51"/>
    <dbReference type="GeneID" id="37161523"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1660.10">
        <property type="entry name" value="EreA-like (biosynthetic domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1870.10">
        <property type="entry name" value="EreA-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052036">
        <property type="entry name" value="Hydrolase/PRTase-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014622">
        <property type="entry name" value="UCP036794_erythomycin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31299">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31299:SF0">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036794">
        <property type="entry name" value="UCP_erythr_ester"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159501">
        <property type="entry name" value="EreA/ChaN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH55056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="446" mass="51286" checksum="B19E62FF52F00460" modified="2022-01-19" version="1">MSLQNLLTTAARPLPPIHDPSFASHFDSFANYRVVLLGDGSHGTSEFYAARAEITKRLIEHHGFTTVAVEADWPDAEAIDRYVRQRPGPQAHLTNDKDEPFQRFPTWMWRNREMQDLVEWMRDHNANLPDHQKAGFYGLDLYSMGTSIRAVVDYLDRLDPEAGKLARRRYGCLQPWVDDPTAYGLASLRGLADCEKGVVDMLRDLLRKRLQYAEEDPHNGEESHSSQQNAYLVRDAERYYKAMYYSSASSWTLRDTHMVDTLRRILRHKPPGSKAVVWAHNSHCGDARYTSMGSRRNEVNIGQLCREQFGRDKVALIGCGTHTGTVAAAHEWDEDMEIMKVKPSRPDSWEWLAHQTGIDSFLLDLRPTKMSPELRSLMAAEDQRLERFIGVIYRPDTERMSHYSQADLQNQFDAYVWFDSTEAVKPLERVQPRTAMGTEETYPFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJR0</accession>
    <name>A0A8G1VJR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_170497</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510910.1">
        <property type="nucleotide sequence ID" value="XM_025654287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJR0"/>
    <dbReference type="GeneID" id="37157689"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="84"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="429" mass="49231" checksum="D95F17E8A02350FC" modified="2022-01-19" version="1">MLKLRCNLRNLLPCLSHVSQACIPRFPPSLIRRVTSQGLPPRQFPTSGYVTLDPLDKIEEETLPFYKPENYYPVSMGEVFGSGYQVVSKLGYGTSSTVWLCRDLREGIYYTLKLCAKGESSDRETAISKHLEQSVSEGRKRMLRMILDSFDVAGPEGSLFVCLIYQPLGMSFTEFQDLLPDQRFSKDLIQRSTQLILIALSSMHESGVVHTDISPNNILQGVRDSSILSKMEEDELKRPIARKVLSDRSIYYSRPMPVCSGLPVVSDLGEARFGKEKHYGDIMPGIYRAPEVILEMEWDYKVDIWSIGNMVWDLAESHHLFYAKENGTLSDEQHLAEMVSLMGPPPPEFLMRSKRCENFWDAEGNWKGSICIPEQTFGLRELHFSGEDKVLFLNFLRRIFRWLPEERPTAEELVYDDFLMQPIMAKRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKH0</accession>
    <name>A0A8G1VKH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box and wd40 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_503769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511630.1">
        <property type="nucleotide sequence ID" value="XM_025664253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKH0"/>
    <dbReference type="GeneID" id="37167655"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="237"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="439" mass="48818" checksum="82EE48C941D73CBF" modified="2022-01-19" version="1">MASDAQSISSLEQEDDIMSCGENEYEIDQHKFLRHWKYCIRSDFASLSGVPATWEDGHPKHWGQEEAKIFLDGEATTPAISPDNQLVAVGIANDIHVFRVDTKERIDVLRGHPGEVITLAFAPSLDGGSIDQPDAPQYLLSSQSEDEGGVHGYVIVWELAQNGKKMSPPKKEEEQPNFAAYHDETGSMHCFPGDLGSFGSQAFSPDGKTMVYVVQNMTSDYYTGQCRYSPCVTLWDVNTSPDSTLAASISWDGTARIWDVLSGRSIHIIGPLGGQLWCGAFSPDSKFLAVSRGGENLIHIYNITTAQQVSLIELPTWCRSMSWSPDGSFLAGGLEIGALCLWDPYTGIEKQRWSLKFDDFMMQEFATIAGAQFVGDRLIFRILEGTVEVYDLDTNLKKQFTRGPDDKISRCPRGEMACSSDFKILIVPDVHRTLRFWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKQ6</accession>
    <name>A0A8G1VKQ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sex-determining protein fem-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_471604</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511870.1">
        <property type="nucleotide sequence ID" value="XM_025662482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKQ6"/>
    <dbReference type="GeneID" id="37165884"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055497">
        <property type="entry name" value="DUF7069"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23239">
        <property type="entry name" value="DUF7069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="62"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7069" evidence="3">
        <location>
            <begin position="262"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="2">
        <location>
            <begin position="340"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="618" mass="69994" checksum="EEFEEB1A2029DD31" modified="2022-01-19" version="1">MRLVEVEGPNSGSQAGTNDGSIQYTFAQCSTSRDERVEKFLDLLNTCPYEDRKNRNDRRVPGTCEWFTTHPKFTNWQQCSSHDAAGLLWVSADPGCGKSVLTRYLVDEVLVGNEQQTVCYFFFKDDFPDQRSAVNALSAILHQIFLAQPQLLSDEDVNRVHNHGESFLQSFHTLWDILMSVSAQATAGEIICILDALDECRDRDELIEAVNMFYQGLYMDRKLKFLMTSRPYPHIEHRFRELKTELPIIHLSGNGEEEVQQVSREIGLVISKRVRDIGKQRSLDDDECNLLEQELAAVENRTYLWVSLTLDALEKMPDFTKGKIRQAVQHLPATVDSAYERILDRSSDKEKAKVLLHMITAAVRPFSLEELSLAWAIHSNPDDTTLSSIRDDMEPKERFRKTLRDLCGRIVVVLDEKICLLHQTAKEFLVQSNKSTVNTCTSRVTGWKGALKPEESNVILAHICISWLPRISAAQGNIERGDFDEYSSCHWVTHYHQAHVQDGSILIMRAQSVCDPSSDVYPAWSKLYKLGGDYLPGGDSSLLIASYLGLTGVVKLLLASDSKDADRRPPLSWAKSTMKHLLRTKRVKINSKDPVEGLTPLSWAAKNGHEEPRTAMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLE8</accession>
    <name>A0A8G1VLE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_452061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512560.1">
        <property type="nucleotide sequence ID" value="XM_025660735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLE8"/>
    <dbReference type="GeneID" id="37164137"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="279" mass="31393" checksum="AA3EE86D37BC8D0D" modified="2022-01-19" version="1">MSDLLKSRWAPNPSEIQAQPAVPPITTPAIPPKTIPKPSTKRTPSPVKQPSRQSSPRPSPSSHLSRFMKIVERLKWKLPYLAYGYRLATLDPASSDFDVSHAEIMFKLDFHEYYSLLERAIVHLLSVFGVSVSSAFARNHLAAYGSAPLSTHRYHANVLEALQDENSPLHTVLGQGEVHEQLQRAKELRNRWKTADLTKEELEMEDKWAARRKGKAMPLASYDIEKILSDIFQGFDDAYLLAQEHVVASDGADKMDGLLQGESDADWDFIVDAMDWEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLX5</accession>
    <name>A0A8G1VLX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD binding Rossmann fold oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_292798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515963.1">
        <property type="nucleotide sequence ID" value="XM_025655283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLX5"/>
    <dbReference type="GeneID" id="37158685"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF7">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="67"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="3">
        <location>
            <begin position="257"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH58041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="420" mass="46194" checksum="54124CB04128411C" modified="2022-01-19" version="1">MSSTSTTLRVGILTADEGAKAIQAIYLPALRALPTSFQVQAIHDGSKQPLSYETDINGNICNDHDHHHQQQHGTSTSTAIPVAPTPEDILSNPTIDLILNFMPNEYHETYTIAALHSGKHVMVETPLSLSIPSAKRIIEAEKHAPNGAKVFVACARRYAPSIASVFRQEVASLDRIYYARCRNIAGPSSAHTATAPRKQVWNEVNGHGQPFPISPPSSPSDSMTGKTRPQLLQGLLGEAFLGQDLSKERVALCEFLASLGCHDLGLMRDTLGYPDAVSSISVNEPYYSAVFHYYSGGKSEHAFTLMYETGTDAVPRCDAHLTIYGDTKTVSVQYGLPYGRRHGVKVVVETVDENGDMKRSETVSAWEESYREELKALHAYLTEDRAVKTTAKDAIQDLRLFQTIFEQYDRQCGTIRTPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM98</accession>
    <name>A0A8G1VM98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ab-hydrolase associated lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_448476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516338.1">
        <property type="nucleotide sequence ID" value="XM_025659940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VM98"/>
    <dbReference type="GeneID" id="37163342"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000193">
        <property type="entry name" value="Ab-hydrolase associated lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="3">
        <location>
            <begin position="221"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH58416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="637" mass="71793" checksum="98AF91E7BC5E107C" modified="2022-01-19" version="1">MFISESDPDEGLSTSVARGAESRVSDKAPYFDTTVEVGSIEQHPAPDAGLKAPLQTGYELQDLGPVCDEDSENASAVTERLLGEEGPFPWKNQLGSSIANTVTHPLFPPLPSYGPPSLITSVQHLIIRCVSFVLSLVFLGTVILGAIIQTASASVLQIRRKIGGPSLRTTRLFHEEERSRQVERNKASRRWSYRREKEVDEEALDECPPLEGGKDPVVCDVAYYARRVGLDVETFKVQTEDGFILTLWHVYNPQEHTPLPPKARRPRGPHFFTGQTNPEASRRTPAKYPVLLMHGLLQSAGAFCANDDDSLAFFLCKSGYDVWLGNNRCGMVPEHTTLFQSDPRMWAWNIQQMGVLDLPALVSRVLFETGFEKLGLVGHSQGTAETFIALAKDQRPELGERISVFCALAPAVYAGPLVERVYFRFMRIIPPLVFRAFFGIHAFIPFMMTVHRRLHPRIYGTLGYYVFSFLFGWSDARWDRGLRDRMFQFAPVYVSAETMRWWLGGECFAHQKCILATSEVTQAEAAEDQRVARGHGEVLRSDTAWYGPQMPPVGLWIAGSDGLVDGRRLLHRLENGREPHVRLAHAKVIEEYEHLDVLWAMDAIDQVGQEVRQVLWETMPQEARTRCRMPRGVWTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMP9</accession>
    <name>A0A8G1VMP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_290383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515902.1">
        <property type="nucleotide sequence ID" value="XM_025655261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMP9"/>
    <dbReference type="GeneID" id="37158663"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="361" mass="39095" checksum="7501C900F6F66C71" modified="2022-01-19" version="1">MAHSLPTPFTPNSDFAALDSHRFSTGPITITALARFEFEAGKANDGTKIMMIEWEDDAIARSSSFPGGSWHVAWEGKTAVLPADEKTSDNTRRMYFLLPPHVTIPPTVTLSYEPPAHAPPSAKNPEPMQLNPLPAIFPPELGADGRSAGKKGVLHTIWAKKRLQVLEKEIRDECLNNAEGIALHMALQEKEWIESNFGVSLSPDGPKVVGQSHPDPHYPMGPATPVSPSSGGKLGEKLKGLKLQTSERELSPKEASARHLLSPQSPDVAVSSFNSFHSIHRPTRSPAPAAPEALRTVVHYPPESVQAQQNVEHHTGFASMGGMARTASADSGEELFAKALSPRTPDLPRSPFSFRPEGLQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN66</accession>
    <name>A0A8G1VN66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_448509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516382.1">
        <property type="nucleotide sequence ID" value="XM_025659948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN66"/>
    <dbReference type="GeneID" id="37163350"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF12">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="638"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="228"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH58460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="813" mass="89946" checksum="7FF069616B5F8C7A" modified="2022-01-19" version="1">MPGPTASDFPSSSSSSASESSSSTSVLPGPPSTRARSPSACTVPRSSHPWTPDSLPSPNASSSTRLQMPSIEDPAPAVSSDASAAGIHGDTDDRNTSELAASAFLAVPQYTHVFESPDRPYATSSEVVNAVRARDDLLVRQTVPDHAPNPSSPPVEWYVSDSEMTDALSEMGGVPLEPYIGGHVGMAALLNQSLDTPVSAHHVASTISSDTEDGEATDLIMDYEPSVMENRSTSQSIAEDDPDDTQKFYSDDGDEYDDDVASDMGTRHGTAYLSEEELEDFYHDPPSPSAPELSDLGPGSMRDDYSNVFSEGDDSSNADPTGETHFAAPVVGTTRERNLNVDQFIAQWLYQSSAASAIPSLSMSSAHLPRSAIAHLIGWIPPPKIYRPPGYARDFYDLQQIPWWDALRIKRAYVRELRDQSYTSYHNLEYSRQRPGARLPQEESYFRGKAMYTEHKATIEHFQLRNLMSVAAYNTVHFAHESKVYSWVPAYDDLVCLLDLSRPTVESGLQGPVKISTMKSAHDTTIAGGFSGEYAVRAAGTTGPGVQGYVTKDANGITNHVDIIPSRTNRSPQGIFASNDRHLRVLDCETNTFVADHELSRAINCTTTSPDGRLRVLIGDSADAWVVEADTGRPVHPLRGHRDFGFACAWAPDMHHIATSNQDKTAIIWDVRMWRMLQKIESDVAGYRSLRWSPVGGGPRTLLLCEPADRIAVVNAQTYQRRQVHDFFGEIGGADYAPDGSTIWVANTDEHFGGFLEYERRQWGQRYGLRDRPNEWLRETELDDDERCMLTERERQQRWMWTLEDEEHEAMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNB2</accession>
    <name>A0A8G1VNB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Restriction endonuclease type IV Mrr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_467349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517538.1">
        <property type="nucleotide sequence ID" value="XM_025662182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNB2"/>
    <dbReference type="GeneID" id="37165584"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH59616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31699" checksum="3BDDC5829FF7723A" modified="2022-01-19" version="1">MTTLSPLTRRLYKLPHPPIPPSSSSHTTLPSFLAHASRTSLPPTSTTYIGTHYEYTIQSTLRSSALLLHRTGGRSDAGTDLVGTWHLPAHEHPPRVLVQCKALKTKLGPNIVRELEGTFASAPVGWRGTGVIGMLVSPREATRGVREALTRSRFPLVWCLVGLEGRVRQVLWNERVEGVVGDGLGVGVVYRADAGEQDAEARVTWDGEDVPGVDAVVERMEVMQRRWFELWGVGEERWEEVLGVVERLFPFEKPLLYARDGRVSGLSEEEREVVMGELRRCQSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNH2</accession>
    <name>A0A8G1VNH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-C domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_519448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516519.1">
        <property type="nucleotide sequence ID" value="XM_025665053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNH2"/>
    <dbReference type="GeneID" id="37168455"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034330682" evidence="2">
        <location>
            <begin position="29"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="809" mass="89688" checksum="2267DB9FF2698536" modified="2022-01-19" version="1">MAPRMSLGTHALLVLGLLLVVLPTQAWAFGAGNIASISAVEGKNWRHGDIEDMLKTIAFIKGHKWTSMMVKRVYFGNWLRDYSQAMDVGTLKSLPAETIRILVWILSFMTFGYATAEFEVTSERLGVYRPEEHIDNPKDYADNQDAREFDQRLRGPVRQVELDIDPETGMKNYIANEEGGWATSAAYIKYSLARSIHYGRTYTHGSQKGNEEDLCEALRCLGQGLHTLEDFAAHTNYIELALREMGFRNVFPHTGVDTQMNIRGHHVFPLVTGTFGMVDFFHSVLGEANDHFTQSEVNEMDIALGDAEANSSGGSLGAFTGLLGNIPGTKDLVEEAEELKRRSEAQESANRSYGARSGYTTRGVSREVDDYSAPRSRGFDDEVPTYRANENERPGESSQSGSALQDFDPSKTIAQIYPILEFRDKVVRKLASIIEKIPGLEAIVEKITETLTVFVMSLLAPFIRPLINAASKSLQAGSSGVIDASGKHQYEPWTDPNCTDPTHSLLSKDHFSNILNEPAGHVASAILKYVAPRVLYAWQNLDVSDDQVLEDCLKVFHHPALRNMNNEAHRTMFKAVQAWVDSRQDRGADLNDVLSAEGVRQGKNSTGEEGHSHSHGGGGFGAAGHSHGSQQQRPPQQQQGSSPLPWDKLSSLPIPGISNLNKLNSAFSNLMVGGGTRGESEDAENPTQYESRVESQYTTHHQSSHHEYSSYQHQSQSQSQYHHSQEQSYQPAPPPPSGFDRYGGYDEYNGSQRRHHGEHHHSHQHHYPPPGRTPPPPGPPGGYEEQSYSSYSSYGRGNGHSQDYYGGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNQ3</accession>
    <name>A0A8G1VNQ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="4 16">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_448815</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the NSE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4 16"/>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516759.1">
        <property type="nucleotide sequence ID" value="XM_025660027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNQ3"/>
    <dbReference type="GeneID" id="37163429"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16493">
        <property type="entry name" value="RING-CH-C4HC3_NSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000725">
        <property type="entry name" value="DNA repair protein Nse1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.220:FF:000003">
        <property type="entry name" value="Putative DNA repair protein Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="241"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="303"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH58837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="347" mass="38530" checksum="6103CFCEF8CC2AE3" modified="2022-01-19" version="1">MPRYAEDHERYDDSNRAFLQAFMARSTMTFSEAKPVLAAIFSVRDDEQVSPEDITEDDLQTYIAAANSAISPFDLEIRSILPQIEINNNDPNAPPPPAPERVYALVNTTSDALTQLATTYSADEIAFVKRILDAMFDTYNTRRQEAMVISSMQALQLAKAGAGDANRRESGTQQQQATQGGAAQSLTMTQAETMLKQLVEQGWFEKSRKGYYRLSPRGLMELRGWLVAAYNDEGIRKIKFCAACRDIITAGQRCGDRDCTGRLHDHCMRNFFRMQKSETCPVCKSAWPGDRFVGERAITMSDPAAQRARRSAANTQQAEAGPSTQFTLPELDVEDEAHGGEEEAGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNS9</accession>
    <name>A0A8G1VNS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_476781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517042.1">
        <property type="nucleotide sequence ID" value="XM_025662799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNS9"/>
    <dbReference type="GeneID" id="37166201"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034013401" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="31"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="131"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH59120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="298" mass="30688" checksum="80415281A49DED46" modified="2022-01-19" version="1">MHTLKSLLLTALTLSSTLTAATTTPTYSITEPTSGAIVSLNTATVISWNTTAPSTSKLSIHLSKTTNETTNLYTIATNISNSGSISWSPPSRVGTGSDYIVVLEPSSSSETYTSSPFTISSSTNASTTYYPTEGEVVKTGQTTIITWEVERNVSEVSIYLMEGELKNGNGTANGSGLKNVTTITTDIANSGDVACVLPGSVKSGDDYRFAIVDVKDEGRVKYSAVFEVVNSGDDSSSGSSSSGSGTSDSSGSSSSSGDGLESAAGNGKETSGAAKVWGWGWRKMGWGVVGLVVGSLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNY1</accession>
    <name>A0A8G1VNY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_35192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515110.1">
        <property type="nucleotide sequence ID" value="XM_025655481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNY1"/>
    <dbReference type="GeneID" id="37158883"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="119" mass="12644" checksum="FBDC73FE0004388F" modified="2022-01-19" version="1">MYSIKRRPNKLIFKAQPSPNAYSKPSSKRSAQRAGSRPTLAIRQPDISLLTILTTGYITTGKGKGASAKIILEPQISCSSELLGGDCFGDGIPIYYSFGGLWTGGSVVVVVGLPSWVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP17</accession>
    <name>A0A8G1VP17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_448115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517089.1">
        <property type="nucleotide sequence ID" value="XM_025659869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP17"/>
    <dbReference type="GeneID" id="37163271"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="180" mass="20478" checksum="1DE0E4259B17445E" modified="2022-01-19" version="1">MKTLRSHKSFIMRYFPNYKPSHVASRYLNADVHPLQPKITHMYATRDKSTLWWMVNPSHLMSVRMKRVVRSWCSRRARMAFRLALKDHGFDADGRKAGQELLGDSNGKGGNGKNLKGRVDLLLHADILREPFEVLRKEMDAGVSALVNHLKTTKDAAPKPAKKQKKAVDARDDKGNETSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP95</accession>
    <name>A0A8G1VP95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_246500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SPC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517537.1">
        <property type="nucleotide sequence ID" value="XM_025654894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP95"/>
    <dbReference type="GeneID" id="37158296"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11565">
        <property type="entry name" value="RWD_Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038066">
        <property type="entry name" value="Spc24_Fungi_globular_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143026">
        <property type="entry name" value="Kinetochore globular domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH59615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="200" mass="22691" checksum="AEE6608E78FA8705" modified="2022-01-19" version="1">MLLDENPAGLINHTIGNFNIHPDKQAVTRINDSLAALQQSRELRTREAESALRKLSRHLSALTAQHEEAVTAHDSGKHAAEMVELDTKKFRIAKSATELEIESERLEGELEMLKERLADLEAQGLEGDEPTRREREMDDATLLRLKIYRSLGVDIEADDAGNFTKAVIRNSRKGDVHVVNIDPKFSRFFYSNYFWSTMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPD0</accession>
    <name>A0A8G1VPD0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative mitochondrial import inner membrane translocase subunit TIM23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_457661</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517464.1">
        <property type="nucleotide sequence ID" value="XM_025661535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPD0"/>
    <dbReference type="GeneID" id="37164937"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH59542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="202" mass="20775" checksum="C46A8A90C7743144" modified="2022-01-19" version="1">MSNIWDSITGRKQPKGSEATASAPDATSFLADLPDPSQLHPLAGLNQDTLDYITLEDSALDQTPGSRSVLPSRGWSDDLCYGTGTTYLAGLTLGGAWGLAEGLKKTPVTAPPKIRLNGALNSITRRGPFLGNSAGVVAMVYNGFNSGLGYARGKHDAANSIVAGALSGMVFKSTRGLKPMVISGGIVAGIAGGWTVLSKAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPH7</accession>
    <name>A0A8G1VPH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_282547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515665.1">
        <property type="nucleotide sequence ID" value="XM_025655211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPH7"/>
    <dbReference type="GeneID" id="37158613"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="86" mass="9968" checksum="CFF4BA2160328E11" modified="2022-01-19" version="1">MIIIFIDSIYFPIVTIGSCCLFIALTFSINAFSLLISGSRLISATPYWLRKLSHYCIVVSYYSSSRVREIRLLVKSPCSRTWCYIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPI4</accession>
    <name>A0A8G1VPI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Lysophospholipase</fullName>
            <ecNumber evidence="3 9">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_447738</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the release of fatty acids from lysophospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 9"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517792.1">
        <property type="nucleotide sequence ID" value="XM_025659779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPI4"/>
    <dbReference type="GeneID" id="37163181"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00147">
        <property type="entry name" value="cPLA2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000024">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLA2c" evidence="11">
        <location>
            <begin position="159"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="44"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="615"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="677"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="725"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="817"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="817"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH59870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="836" mass="92829" checksum="8D95CA7C28481E6F" modified="2022-01-19" version="1">MGAAKALRLRWTVPPTLLIALGGGLLYTTSGRTQSNKQLLLQTGPKGFFSTSSNPDSDKRSDKSSGSSDWNPLGHGSKEDPHHDAGSIWTNVLQKFEGVKQSVGTPDWIELDNIKNYIIPDWTRLLPLSVQKLQRELSMAPGSLADDIWHEAHDPDINPEILRKAKVRVGDTLCNEELAYRQKRQKYATAALASYLNIPEDEIHPDDVPIIAMCGSGGGLRALVAGTGSYLATQEAGLWDCVTYTAGVSGSCWLQTLYHSSITGRNFNKMVDHLKNRLGVHLAFPPAALKLLTNAPTNKYLLSGLVEKLKGDPGADFGLVDIYGMLLAARLLVPKGELGVCDRDLKLSNQRYNLASGAHPLPIYTAVRHEIPVLENQENLEKREKPEDLIKESKSEAWFQWFEFTPYEFFCEELSAGIPTWALGRHFHGGVNVKPEEISPIPELRVPALMGVWGSAFCATLSHYYKEIRPVIKGITGLSGIDSLIQGKTKDLVRVHPIDPATIPNYVLGMKDQLPPSCPESIFRSRHLRLMDAGMSNNLPIYPLLRPGRDVDVIIAFDASADIKQENWLSVVDGYARQRGVKGWPIGAGWPREDEQLKQTEETLRQAQNISQKELANKMAEAQDKSKPNSPTTNQNTTSNNTTTTPPTSAQHKKKNHPSTSTDLDYCNIWVGTTQEMVSGQEPPPSKRLFHPQDTDHSESDFHLMRPDAGIAVVYFPLLPNPSAPELPTSSSLHKSRTPARKSENTSKARVSDPAKPLTPYPGTINPDVDDFLSTWNFVYTPEQIDSVVGLAKANFAQGEDQVKRVVRAVYERKKNDRLQREERESRQRMEGFVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPL2</accession>
    <name>A0A8G1VPL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_436874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="148"/>
        </location>
    </feature>
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        <location>
            <begin position="175"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="681"/>
        </location>
    </feature>
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        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
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            <end position="117"/>
        </location>
    </feature>
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        <location>
            <begin position="266"/>
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        </location>
    </feature>
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            <end position="314"/>
        </location>
    </feature>
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            <begin position="342"/>
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    </feature>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RAH59945.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="681" mass="75937" checksum="D786F89F74820AF3" modified="2022-01-19" version="1">MSGKVPHAAFCEEYDEDAHVILPDTRQVANLTSKRSKPVLRSPAAPLVDVASDSGYSSRTAATVNSTQSGPSGRKSPVPLKLDTTLVKRADLGRVRSKSSREQSKPRIVRPPREDKMQVGAYPNGVSHAPAHAQRSPSRPRRRETSQMRHYPGTCWECDQGLYHASSTPVDSRPSMDYPYYMSQPPSSAHDYPPPPSPRGDPRYAPNPVQDIHVSRSSRPSARGGGPIYHPNNRPVSFHGMLPGMGQMVYQPSSMSRYEHGPPPSSSAYAYNPSSYAPSHYSQQSPYYSGMSDYGAPSEHRQERSVSSTRDGRGRRPSVYGAPVVDYDSASAAFDDDEPLDAAPPVPPPPPREPRPRLPSHSSHDRDEDYYRRPPLKHKNTPQIIQKRPEPRKGVSAPSVTSDRHSARSFDMADMKDALPDGYGYRRSSRETVVPARSRSYRRPTAYHESARPSRIAVENSRRRQPTIYDFPDDDDEDEDEDEDEDDEMDEKHREAEEYQATRTAKPPVPPAPPVPLTADALFKAKSSQRAESDSGSQKSRSSRGSDARTQSGSNAGSKPEEDNNIVMTLNGVTMSFPQDGGKKISVRTGEAGAVELNIEGKQRSKKYLTNGSEYTGSVAHSRRELEDARRVREIEDSRRVREIEDARRVREIEDARRVRSDRKSDRASRRSSRSTYGGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPR3</accession>
    <name>A0A8G1VPR3_9EURO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BO85DRAFT_438209</name>
    </gene>
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        <name type="scientific">Aspergillus piperis CBS 112811</name>
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        <lineage>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="37162062"/>
    <dbReference type="Proteomes" id="UP000249526">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="137" mass="15211" checksum="99BF94805D1A7F2F" modified="2022-01-19" version="1">MACAEVGVADGRAALLPEGAKLPGGFAACWIVGFPLWTDGYILEERYKKEEVDEVQYPSKQQQQQQQQHFTFLLYSFILITAGQAGTASALPDPLIHILTLHTPSALPCSWRPKIATIRLGAFGEKARLWRRVAERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPX2</accession>
    <name>A0A8G1VPX2_9EURO</name>
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        <submittedName>
            <fullName evidence="3">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_435672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="RAH61399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025658538.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="37161940"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding_CS"/>
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        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
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        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF15">
        <property type="entry name" value="AMP BINDING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </feature>
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        <location>
            <begin position="457"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="548" mass="60212" checksum="DCE9729EFF396A0D" modified="2022-01-19" version="1">MGLTNGQSIQGQDAEHQALPLTALPSLPLFVQANAFAQNTPDKIAVVDATKGQEFTYGQLLADAVALKKVILEELGLTKVGNLEERRIAFLTPNGYDYVVTQWAVWAAGGVTVPLCTTHPVKELLYTIGDSDPSLIFLHPTFAHFETPLKESISKPIPFKPLTPHQQTTTSITLPTISPISFLNHRALMIYTSGTTSNPKGCVTTHKNITFQAQCLIEAWKYNPSDRLIHVLPLHHIHGIINGLTASLLSGVTVEMHPKFDPATIWTRWREGGSTMFMAVPTIYSRLIDYFETHLRGTEHEAAARSGAQSLRLMVSGSAALPTPVKSKFAAITGQVLLERFGMTEIGMAISCGLETEKRVDGSVGWPLPGVQVRLTDKESGKVVDAVDEDGMIEIKGDNVFIEYWRKPEATKKEFTEDGWFKTGDVARRDAQGAYFIQGRASVDLIKSGGYKISALEVERKMLGLDAIQEVAVVGLADEEWGQRVAAVVKQRSGTEPLELASLRAQLKQEMAPYKVPTVLKLVDAIERNAMGKVNKKTLVQKYWPELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ47</accession>
    <name>A0A8G1VQ47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras guanyl-nucleotide exchange factor RasGEF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_274177</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025655124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ47"/>
    <dbReference type="GeneID" id="37158526"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF348">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="407"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="660"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="379"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH58388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="913" mass="101371" checksum="C60DD6C059C83BBA" modified="2022-01-19" version="1">MASQPLRRERASSDKADAAPFPQRPGLPSRTISAPVGGLYRLDSARTAMESGNKVDRTLLEEDENPPSAGGDRVPSSTREETTPKPSFPHVSIAVVGPDHVGKSTFIETALDMKHPLTSRSTTKKMSLDGTVYLVRLMEIDTLEITIGSNGEVNWPLLGSDSPPTVDGVLVLLDMTQPASFPEFTELLDSLTASDIPFTLVASKCDIQPPDSPVEPILGGYEIHRTSPDSPRSQKMCIALVLRSVINRKYDFIDFPSNSSATPDWHHSRTNSETPTAVLSGAAGGPITGPLDPAVDGYGVDRQPTDPATSANLASNGQAFRYARSNSHPVRPHTPPSGSRLASRKQSVSGESSPSKDLNRQHRLHTAWRNSGGSDAFSNFLEMGEDFDGPRSAPSSPGSKDQTPSESSSNDAGFTFDELVDRLVAQPMSKQDSKFASIFLCLYRKFAAPCTLLNALINRFERNENDMTDQLDRIAVQLRLLGVMAQWVSEYPGDLAYPKTRKRITDFVTTLEKSHFYMFAAKEIGSYLEGNADDDNIGWPYRDGDMEEPDTADPPFQFSGRSSPSIFLGAPPLGDEGEEEEEDPIYNMSALDLSEGAAEPASRLSGSMSNSFTSEKPGTIASQSFTFLSTEAAQREAHNLDLTPRIPLTKIQWRQLMEIPDEDFARELTRMDWIMFNSFRPRDLVRHVSISGVEKDKILSLKHVNRMIKQFNHVAFFVASVILLRDKPKHRAKALEKFMNIALKLRRLNNYNSLGAVIAGINGTPVHRLSQTRDLVPVQTQKDFMRLVILMGTQKSHFAYRLAWDNSFAERIPFLPLHRRDLVSAEEGNKTFVGDNKNRINWRKFEVMGEVVLGIQRSQKTPYPHMSKYEEVERLILEIKLSGDDEDLYSRSMQVEPSAGGDTGRKKFGWLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ78</accession>
    <name>A0A8G1VQ78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_509421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518512.1">
        <property type="nucleotide sequence ID" value="XM_025664496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ78"/>
    <dbReference type="GeneID" id="37167898"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="100"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="307" mass="34484" checksum="5F16FECDC87716E4" modified="2022-01-19" version="1">MPSKAFVFCYTAYSLVTVPARLVVVAVYNIPRFLRPNAAWSYKTAFYKGITCSVPEVEPLSIGAFWFPEAPAKPPQQLIIYFYPGAYMMFGSRPSKTGDPALAIQYRLSQDKKTTFPAALQDGITAYIYALEILKIPPSQITFAGESAGGNLVMALLCYINEETPMLPLSCCAILSSPWVDLSSKAIKNVPLNRNYNTDFIKQNFLDWGRKAFTPERWDSSNSWITFLGNETQLDIPVFVNTGTSEVLYDDIMKFAENLREKGNEVEVLESLNAAYVPYRLGKNWNMEEAQAICLKTMTKFLEKTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQH5</accession>
    <name>A0A8G1VQH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_456578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518797.1">
        <property type="nucleotide sequence ID" value="XM_025661457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQH5"/>
    <dbReference type="GeneID" id="37164859"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH60875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="97" mass="10983" checksum="AB782168E31EC7EB" modified="2022-01-19" version="1">MRKTSRPRTLPLISSQCHPDNSLPYCATCLLYHSLWPLPPVAVHQNSPLPPARFPMGRDGLHRMATRPSDAELFADTPIPRGLSTYSPWLYSYTHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQL6</accession>
    <name>A0A8G1VQL6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_352185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516820.1">
        <property type="nucleotide sequence ID" value="XM_025655485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQL6"/>
    <dbReference type="GeneID" id="37158887"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="122" mass="14073" checksum="8C8A570ABB0C2EC7" modified="2022-01-19" version="1" fragment="single">DFVYDIIVQSPMGSKLRRRLTLKFDADVNIMSDDMQHRLGTELRPYHGGPISITGQSHMIPLGTVGVSWAFCGQTKIYKTDFYVVPDMTYDFLIGRPSMRSHELYRVDPEITRRLNTLYQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQN7</accession>
    <name>A0A8G1VQN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pru domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_414404</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518977.1">
        <property type="nucleotide sequence ID" value="XM_025657646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQN7"/>
    <dbReference type="GeneID" id="37161048"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2020.20:FF:000004">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="7">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH61055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="389" mass="41549" checksum="4D8E3C8EBDD216FC" modified="2022-01-19" version="1">MSIAPIITFKAGICDLETSGETSVVKPKPTPGYIYLYSEDELVHFCWRPRSAPHTEPELDLVMVPSDGCFVPYKPVDSTAPTNGRIYVLKFSSSSQRYLFWLQSKSQHEDGNPSWFSQRDLKLGEIVNGLLQGEDVDVEHEIANLPRGGPSGGDDDETMEDVEGVDHDPNHNHGGNSGGAGPDATGGDVRAEGQGSREGGADGGRAAATDSDPSSVVQSFLQSLHGGSRQSQDPERPFTTLQDLLTTSTTLPFLESADEQTVDNLLSFLPPSLLLLAQDNDLEEAAAADQDPDIAQAALGSLELTQKKEILRKVLHSPQFAQSLASLTMAIRDGGLPSISEALKIPVANGGFMRRGGVPLGGGDAVEAFLQGVRDHVKDSAEGNRMDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR76</accession>
    <name>A0A8G1VR76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exosome complex subunit Rrp46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_362256</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519532.1">
        <property type="nucleotide sequence ID" value="XM_025655620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR76"/>
    <dbReference type="GeneID" id="37159022"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000036">
        <property type="entry name" value="Exosome complex subunit Rrp46, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH61610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="249" mass="26018" checksum="9D640EE9B9CEAF83" modified="2022-01-19" version="1">MVGPTATLTPLARADGSASYLCPSTGSNILGSVNAPVELPGRRDALKPEEATVEVFVKPGTAPAGVSERYVEGIIKGVLGRLILGRERGYPRRGVVVTLAIVGGGSVGRGEPYLTLLPALLHTALLALLSAAVPLSMTFSATVLAVDASGEIIREPSIQQAATAKSLHALAFSSKGHLLLNESSGAFDFETWEKVHQRASAICHGTPAAGTDGDIAMVEDVDGQPLEGIMRESIEDQVHRDYAWKIDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRA9</accession>
    <name>A0A8G1VRA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_10003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520791.1">
        <property type="nucleotide sequence ID" value="XM_025653766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRA9"/>
    <dbReference type="GeneID" id="37157168"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="155" mass="16750" checksum="C217ED5A638696DE" modified="2022-01-19" version="1">MDEPRIAPHSHHHKTSISTLPQPYILRLAHLPPSRKSLGCPWAGTDWLGNHGGSLNRVSQCHADHAATPGVGAGIHRPFTGNLYALNPMMAVELAVGTTSLERAVQVPLPSPSRARHGVRVFVPSRGHPALLPPDRKVTPILFQLDTFSAGFEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRI1</accession>
    <name>A0A8G1VRI1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear pore protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_447658</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517720.1">
        <property type="nucleotide sequence ID" value="XM_025659767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRI1"/>
    <dbReference type="GeneID" id="37163169"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH59798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="375" mass="41798" checksum="E05C85411C087982" modified="2022-01-19" version="1">MAGFADFDAGHRDLVSVTKFNFYGNRIVTASTDHRMKVWDQKDGEWQLVDTWRAHDAEIRDATWNGPFTGQHIGSVGEDMKCKIWQEDVTQPPNSGRRFRSIFRMTAPQRHPFVSIDFRNIDLESWMAVITRDGYLMIMEPVSPDTLADWQPLDQFRVCTAPQRGEETSFKVQFHHDPSDITHSVLPSSDRKSLSLVVAAMDSVKIYRTDASRRFYHAIELTGHGGLVRDISWANGSVRGYDLIASGCKDGFIRVFEVYTTASGSGSQTSNGNHAHSSSQSSSIRATTQSGIGSALASRAPVSMSSRAAPADSQFKHSFKEIACIDSKHLDVWQVGFSYAGDCLISSGDDGIVRFWKKSLSGEWLEYAETDMACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRP4</accession>
    <name>A0A8G1VRP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_20566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521211.1">
        <property type="nucleotide sequence ID" value="XM_025654573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRP4"/>
    <dbReference type="GeneID" id="37157975"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034851539" description="Extracellular protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="38764" checksum="F31EEC377A31456D" modified="2022-01-19" version="1">MKSALLAYGLLASSVSAHIQMSNPYPIRSPLDPDGDESKKDYSYTNPLDPSGSDFPCKGYANDPFRSVATYSPGGTYEMDLQGSATHDGGSCQISLSYDTGKSFQVIHSMLGGCPLTESYEFTIPSDAPTGDALLTWTWFNKVGNREMYMNCAQVTIGDGGSKKRDVEEMRKRDAFSSLPPIFIANVNGPGQCTTIENYDVNFPRPGPSVEGSINGTNTGFTCTGDAPFLDAGNSGSSGSSGSSSGSVKDAPVSTPKPTASRPTVSTSHVAAHVVGSTPAASSSAKVVASSFGTEAARVATVPTAVAHSENDASVAGADDDESARYVPGKPCVDGAIICGPEGTSWSMCSNGRPVHMGSVAAGMYCSHGAMHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRX2</accession>
    <name>A0A8G1VRX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_22311</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RBR family. RNF14 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521288.1">
        <property type="nucleotide sequence ID" value="XM_025654725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRX2"/>
    <dbReference type="GeneID" id="37158127"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20354">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23820">
        <property type="entry name" value="RWD_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000024">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000416">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047548">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="14">
        <location>
            <begin position="14"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="204"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="329"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="517"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH63366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="610" mass="68109" checksum="200953945A8C6E21" modified="2022-01-19" version="1">MTELDSFPEDERSVELSSIAAIYPEIKLDPSSPFKASLTLPVKPSAPLRVCFQQQSETEFPAVLTPPTSVDANDPGFSFKTGDHNSASLNRDIHTLSHLPPLCLEIELPQGYPTEEAPVFRLETSPPWLPPSILLGLLDDGKRLWEECGKDLVVYTYIDHLQQLGESAFGVGDISGGEVQLPRELKIALLDFNNKAERERFEEETFECGVCLEPKKGTICHRLVLCGHVFCVPCLQDFYNTCITEGDVEGVKCLAPGCGKEPNSASSTDARPKKRKKQDRTLSPSELLQIPLEQETVQRYVFLKRKKKLEADKSTVYCPRQWCQGAARSKRHPKPVDPMTDDLDASDDEDEEGPVFDPLGEEAQLPPMSERVAICEDCNYAFCCVCKKGWHGELVRCFPRREAELSAEEKATEEYLRMYTSACPTCDAPCQKQMGCNHMKCFKCDTHFCYLCSSWLCEDNPYRHFNDISSGCFNRLWDLEGGDGINPDGAAALHRVPDELLDFDDGSDDEDLVAWELGRRPPPPAPVPPRVNNGAAGGNRHRGNNANDLDAAGRAAAAERQAQARAMAEVRRGPDGEPPQVRRPGLQRFLDLVLNDREDEWDSDELDDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSA4</accession>
    <name>A0A8G1VSA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kynurenine aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_366489</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518515.1">
        <property type="nucleotide sequence ID" value="XM_025655782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSA4"/>
    <dbReference type="GeneID" id="37159184"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="39"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH60593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="428" mass="47967" checksum="8B5AC546CB60DD11" modified="2022-01-19" version="1">MDAQSNTKAFDPPAPRVPSDRLDVWSIVNEAAAVSPIQPIVNLGQGFFGFNPPQFAIDAAKEALNRVDCNQCAPTRGRPSLRKAIASAYSKLFERQIDEGSEVVITSGANEGMLCALLAFICPADEVVTFEPFFDQYRSGIELAGGIPRYVPLHPPKDSNRTISSASEWTVDFEELEKAINKNTKMIILNTPHNPVGKVFTEAELQRIGEICLKHDLLILSDEVYDHLYYVPFTRIATLSPDLYNHTLTVASAGKAFHATGWRIGYLIGPQPLIKNVSAIHTRICYSSVSPLQEAVAVAFEKADENGFWEHSRQEMKGKLRSFCEVFEALGLPYTEPEGGYFVLVNLSRVQIPSDYSFPAHIGQRRRDFMLCWFLIQEIGVAAIPPSEFYSDDHAHIGEDFLRFAFCKEDEVLEMGKQRLLKLKRYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSK6</accession>
    <name>A0A8G1VSK6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_390527</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518830.1">
        <property type="nucleotide sequence ID" value="XM_025656774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSK6"/>
    <dbReference type="GeneID" id="37160176"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="13">
        <location>
            <begin position="16"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="12">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH60908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="311" mass="34975" checksum="8B7FB76879D6F860" modified="2022-01-19" version="1">MTTTFKLNTGAQIPAVGFGTWQDAEAQEQAVLEAIKAGYRHIDTARIYGTEEAVGKAIKKSGVPRDQLFITTKLWNNKHHPDDVAQALQDSLNDLDLEYVDLFLMHWPVAFKRGTEKFPKNESGKPAVEDTDYVDTYKAMEKLLSTGKVKAIGVSNFSKSEMERLLQNSSVVPAVHQLESHPWLQQRSFADWHKSKGIHVTHYSPFGNQNELYSREGTIGKLIDDPVLVEIGKKYNKSSAQVALAWGINEGHSVLPKSKTPSRIRDNLQGDFKLDAEDLQKIRGIDRKLRFNDSSADFGREFFGDLDGKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQY4</accession>
    <name>A0A8G1QQY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_211466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825089">
        <property type="protein sequence ID" value="RAH52023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509945.1">
        <property type="nucleotide sequence ID" value="XM_025654622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQY4"/>
    <dbReference type="GeneID" id="37158024"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="118" mass="12817" checksum="49145F498F3FA959" modified="2022-01-19" version="1">MNVRVGALRLKVVHQCKVLLYCLPCDEEDEGEAVRPRLPAGLPRPLCFCLAQEGLRASGSDWRSQGLGAVICKHQEPWEALVALAGSATSDRSAATYVLWIRWNTAKGANATQATNDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QR65</accession>
    <name>A0A8G1QR65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_453720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510733.1">
        <property type="nucleotide sequence ID" value="XM_025661116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QR65"/>
    <dbReference type="GeneID" id="37164518"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="5">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH52811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="189" mass="22279" checksum="267B36DBC4EAE4A9" modified="2022-01-19" version="1">MRVETCHFCSRPVYPSKGIQFVRNDAKAFRFCRSKCHQNFKAKRQPRRVKWTKAGRAAKGKEMIVDSSLVLSQFAKKRNVPVKYDRNLVAATIKAMERVEEIRQRRERVFTKRRLAGKLARDRKREADRKVVMEGEHLIRKELREREEGQPLVAETAKASRLHGEERLRQKKKTRMLVDGTTQEEMDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSE0</accession>
    <name>A0A8G1QSE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_454283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509988.1">
        <property type="nucleotide sequence ID" value="XM_025661247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSE0"/>
    <dbReference type="GeneID" id="37164649"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="488" mass="54053" checksum="B866A7CC5FB6AF6F" modified="2022-01-19" version="1">MLGAASRRAVAIPRTLAHRHHQHAFSSSSFSTRTIPSILRSRPTGAAPTSLLRTVQATTIQTRPLSFAQKMKRGYQEASRGIWRNNPILLPLALLSVATATAIFSYIAYKEATEVGPQYHKFPPPVAERLRTAIYYTDVKLNPVKAIDAYSEAIKLAAELQMHPYSDEVMGIRLQVTKCLEMAGLVPAAIQVLEKTRADAYHWVKTNMETEAFKRGESDYYFARGPSAEKGELAAEPMKVDPAIAESYEKMKQAEIYEYEQVEKTLAKVVGMSVKLAELYKSDHIQDDKKAEEALEFAVQLSLGEVQRRHQAKVPIGGGNWLTLTEIGTALSELGQHYASKGKLDLSLPLYLRAFDLINANEGGVPSCKQVTLMYNISGCIGYPALDGVAPSSDPGVSRAEAIEAARKWAQGAIERAEKVEPSEDSVECDYSCASAKVMLGQLAVFHNKPEEALKYYYEAKDLYNRLELSSDAEDVSRLIKDLEKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSV1</accession>
    <name>A0A8G1QSV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_523869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510956.1">
        <property type="nucleotide sequence ID" value="XM_025665384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSV1"/>
    <dbReference type="GeneID" id="37168786"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034149438" evidence="1">
        <location>
            <begin position="19"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="96" mass="10394" checksum="79ACD9F97CC83FAF" modified="2022-01-19" version="1">MKFSTVLLTLGAASGAFAYGCTEGLIYCGTSLIKKGDYYEDIVASLERSDQPTTSDFILYSRFICTADEDFLVWVDKCADGACKDNGSGHDDTCGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTB2</accession>
    <name>A0A8G1QTB2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_431574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025658338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTB2"/>
    <dbReference type="GeneID" id="37161740"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="252" mass="28815" checksum="0074F779C4F313BA" modified="2022-01-19" version="1">MSSLPPGWTEERLRTITEDDLRQIPEEQIRQIDLNLIPFDNVRARTIISFAKLFEEQRSSRARKGMPPAPPKDIFKIPDDAVIQVVEENGFDDFGFITFRTDYSDDERWDKWDAEYDRLIDLSIERSAGGQKIMDKCLMPRFEDPELHGATHQQIQQSYYGYIETEGLAPGLDVGLCLVADTAAVESMNSDLPWVYALDMNFDHSSEVEEGEYPGYFRVAVVSVIPELYPILTAMPPAELWSQGDEIWQSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTE7</accession>
    <name>A0A8G1QTE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="16">HMG-CoA reductase</shortName>
            <ecNumber evidence="16">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_492915</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">HMG-CoA reductase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA). In this module, the cytosolic acetyl-CoA acetyltransferase catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthase then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="16">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="16"/>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510498.1">
        <property type="nucleotide sequence ID" value="XM_025663806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTE7"/>
    <dbReference type="GeneID" id="37167208"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025583">
        <property type="entry name" value="HMG-CoA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13323">
        <property type="entry name" value="HPIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0521">NADP</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="18">
        <location>
            <begin position="242"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH52576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1131" mass="121685" checksum="B076128CA4D15C89" modified="2022-01-19" version="1">MAATLIPRKFRSTDAEEDAEPGWLKRQVTSGLQFLSRRACLHPIHTIVVFALLASTTYVGLLEGSLFDSFRNPKDVAGQVDVDTLLQGSRNLRLGESTSWKWQVEDTLTAQDYDTAQHMALTTFIFPDSLSKSASTGPLADGVPIPANTSAQRVPHTPNLFSPFSHDASLVFTLPFEQVSQFLKAVQEIPEPSVDEDEGEQKKWIMRAARGPAYGSSGALKLWLADAWGSFVDLVKHAETIDIVIMTLGYLSMHLSFVSLFFSMRRLGSNFWLATTVLFSGCFAFLFGLLVTTKLGVPINMLLLSEGLPFLVVTIGFEKPIILTRAVLSASVDKRQGARAGKTGGPVAPSTPRSIQDSIQTAIKKQGFEIVRDYCIEIAILVAGAASGVQGGLRQFCFLAAWILFFDCLLLFTFYTTILCIKLEITRIKRHVALRKALEEDGITQRVAENVAANNDWPQAGSENDGTSDASLFGKKIKSSNVRRFKILMVGGFILVNVVNLSAIPFRKSTGLPLLSRVSNLLAPTPIDPFKVAENGLDSIYVSAKSQMMETIVTVIPPIKYKLEYPSVHYAAFGEGQSFDIEYSDQFLDAVGGRVIESLLKSIEDPIISKWIIAALTLSIVLNGYLFNAARWSIKEPETAAPKVEPPEPKVYPTIDLNNQDGPKRTAGECELFLKEKRAAYLSDEELVDLSLRGKIPGYALEKTMENEDLMSRLDAFTRAVKIRRSVVARTPATSEFTSSLETSKLPYKDYNYTLVHGACCENVIGYLPLPVGVAGPLTIDGQSYFIPMATTEGVLVASTSRGAKAINAGGGAITVLTGDGMTRGPCVGFPTLARAAAAKVWLDSEEGQSIMMAAFNSTSRFARLQHMKTALAGTYLYIRFKTTTGDAMGMNMISKGVEKALNVMATECGFDDMATISVSGNFCTDKKSAAVNWIDGRGKSVVAEAIIPGEIVRNVLKSDVNALVELNTSKNLIGSAMAGSLGGFNAHASNIVTAVFLATGQDPAQNVESSSCITTMRNLNGNLQIAVSMPSIEVGTIGGGTILEGQSAMLEFLGVRGSHPTNPGDNARQLARIVAAAVLAGELSLCSALAAGHLVRAHMAHNRSAAPTRSATPVSAAVGAARGLAMTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTS5</accession>
    <name>A0A8G1QTS5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="2">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_407168</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="2"/>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510708.1">
        <property type="nucleotide sequence ID" value="XM_025657355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTS5"/>
    <dbReference type="GeneID" id="37160757"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="36"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="9">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH52786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="282" mass="31378" checksum="CAE0D6F722117DF9" modified="2022-01-19" version="1">MSLSLQSTKKMVSGYEIPVLGYGVYKTPPDVTESVTLKALELGYRHIDSAQLYNNEAECALAICRSNIPRSRIFYTTKIPTTHMSYEKAKEAIESSLAAAKGLGYIDLMLLHAPYGGRSGRLGAWRALVEAQAAGKIRSLGVSNYGIRHLEELEEYIRSGGGGEISVGQYEIHPWCAREDIVGWLRERGAVVEAYAPLVQAKRMQEPVLRRLASKYGKSEAQVLVRWSLQKGYVPLPKSVTESRIVENSQVFDFELSAEDMAELQTTEYAPVSWDPARDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUM6</accession>
    <name>A0A8G1QUM6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_380099</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512070.1">
        <property type="nucleotide sequence ID" value="XM_025656366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUM6"/>
    <dbReference type="GeneID" id="37159768"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="256"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH54148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="605" mass="68935" checksum="2DBD7655E60A3DC2" modified="2022-01-19" version="1">MKNRIDHLEDLVKRLIAERKNGLAENTPHTPESSIPDDNKALQGAQSHASEVACAGTTMIDGTRSVYRGGDEWYDVLEEINTLKQTWTETQDEIADEVVRSAPSHIADGSSLLFGQVKPLERIEIVSTLPPKHQVDKLIALFFDTEKFQISVPPILHIPTFMREYNEHWKDPSRTNFIWLGLLFSILGLTMLSFHQFGEPPEYEGISESLFQLYRIRTAQCLLNGDIAKCLPYTIETLRFNATAELNRKDDNRRGLWIMTGVIVRAAINMGYHRDPSHSPSISPFQAEYRRRVWMSVIIMDNMASFLGGFPRTGSTLFSDTMEPRNIHDWELSEGTTSLPPSRPLEEPTATTYIIAKTRLFRAIGRIADFNNTPTVITYDTVREIDQALYDAYEQFPSHLKVHMEGNIIPLGNAAEVSRFSLCSMYHRAMCTLHRKFMAKGLLDSRFKLSHDRCLSSAMTLLDYQVALEPSWYKSSLTRQVLTLAAMILFLELELARRFNNPDASRSIDILQILERSCDLWGRAKDCYEEAGRVYDIIVRMIASFRSESATTSAHALDLQGFSSPFTVFDSVDQSLEKETLDVDIDWTTWDAFIQDTELQDGPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV11</accession>
    <name>A0A8G1QV11_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="10" type="ORF">BO85DRAFT_451757</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV11"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="82"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="221"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH54881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="382" mass="42793" checksum="C01E943D951FDA6F" modified="2022-01-19" version="1">MVRHKKDNFARGGKKFSSKGPRPPRRDPADPDADDADRPSRPPFKAACWDLGHCDPKRCSGKRLMNFGLMRELQIGQRFPGVIVSPNAKKIISPVDKDLLEQFGAAVVECSWVRVKEVPWSRIGGKCERLLPYLIAANTVNYGKPWRLNCVEALAACFCICGHEDWARQVLKPFRYGEAFLEINGKLLKRYAACADEDEIKRAEEEWLAKIEREYEESRAAGGADDIWTVGNTNRRAESDSEEDDEEGSGSDKDNNDEEEEEEEEEDKDPFAISDDSEEEEQMAAIRAKILNSKSFQNPSASDKPQPEKIARPEEEGSKSRPLEDSDAESGSAEGSEDEAFDSIINATPVTDRTGIIAAQKKKKETFSASFSRTVVDAPKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV57</accession>
    <name>A0A8G1QV57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_470789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512878.1">
        <property type="nucleotide sequence ID" value="XM_025662422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV57"/>
    <dbReference type="GeneID" id="37165824"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000014">
        <property type="entry name" value="Translation initiation factor eIF-2B alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1070:FF:000002">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH54956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="353" mass="37425" checksum="3F8A047B695A6510" modified="2022-01-19" version="1">MAAPTSGSSAAAKPFDIVATYNDLLRSDPDLTMPIAAIEALVLLLTNSPSSTISETLDLLEKSTAHLKQSIPNPIGLSAGTDLFQRYLITTLQRPGQLGPAGDFNAIRAHLLSNGRLFIRRAKESRDKIAAFGRGFVRDGSTVLTNGGSRVVASLLQKAADEKGGPSAVRFKVIYVLSSAKGTGAHSDEPEGMETVRALRAKGVPVATIPESAVAYSMGKADTVIVGAEGVVENGGIVSRMGTYQIGLLAKAMGKPFYVVAESHKFVRLYPLSQYDLPIEQRVIDFKTEEDVADEAKQQQALSTDAAVAKAVKTADSADVVDFTPPHLISALITDSGVLTPSAVSEELIKIWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV88</accession>
    <name>A0A8G1QV88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_382035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511156.1">
        <property type="nucleotide sequence ID" value="XM_025656452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV88"/>
    <dbReference type="GeneID" id="37159854"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="113" mass="13149" checksum="30550C8B4274502F" modified="2022-01-19" version="1">MDHYPLLYVRGIPDSGKGTVNQFRRENIMLMTREQEANSFFLPVDKPLEEFDSEDDRLLTQIFGSFNRLCNDPQIFFLVIYFLTLSAWLSDRFIKQVVLPYLPAPGAGMRGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV93</accession>
    <name>A0A8G1QV93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_155615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511533.1">
        <property type="nucleotide sequence ID" value="XM_025654182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV93"/>
    <dbReference type="GeneID" id="37157584"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="88" mass="10086" checksum="19A05AFA35E83A9B" modified="2022-01-19" version="1">MGTMSIMSPIDQFRRMLFPSLTRCFQNARRAEAKGRSFTNRLNRHQPQSWQGSGQVRLGRKLPPVFVDEPAFVPFPLLSVFCFSLIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVL1</accession>
    <name>A0A8G1QVL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Concanavalin A-like lectin/glucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_380958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511713.1">
        <property type="nucleotide sequence ID" value="XM_025656402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVL1"/>
    <dbReference type="GeneID" id="37159804"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034678490" description="Concanavalin A-like lectin/glucanase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="35301" checksum="503ABB97BACD151C" modified="2022-01-19" version="1">MHVLSTLSILPSVALGAVLPAVLQSSTKVAKRDSWGGSVSLGPTKSDIINAVTTIIPGVAPSTQNGELFLWPGMSNGTGDLIQTTLESWPSNSWCGATTGQWCVRASIFGSFGQLDGTGSPVSANDHVRIEYNLASDGETWTQNVTNALTGAALSSYSYAAGPYMTGYGTGTECDSDCTGTVADQLYLNTTITLREADTSFGDTIATGAGATYTGLTSSEGGKVWNIATISIPAMGSQTAVASSTASVATHATPTPSAAGNVSTDEATGPAAASATQESVSVPSIAPSVAGSGAAPTQSSSGSGFKSGAGSGFGSAPFPSGSARGSQSNPQSGAQSGSKAGSGSAPGDDNEPCPEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVN4</accession>
    <name>A0A8G1QVN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_504129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511381.1">
        <property type="nucleotide sequence ID" value="XM_025664281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVN4"/>
    <dbReference type="GeneID" id="37167683"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="54"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="438" mass="49605" checksum="34176380097B62DC" modified="2022-01-19" version="1">MDSSFNVTEHVIQAQYIREYPRTTYPQDAPVKLSIKKYTPKSNQNPQEGDITIVGAHGVGFLKELYEPLWDDLLARSKKDGFRIRAIWIADCANQGASGVQNENIMGNETSWFDHARDLLHMINHFREDMPRPIMGVGHSAGGSQLILLSLMHPRLFSSLTLLDPYLIPDNRDVNALTLFYLTVTRRDIWSSRNEAERFIRRALRSWDPRVLDRWVHYGFRNLPTAIYPEVNKDNGDDEVPVTLTTTKHQEAFTLARANLDGHTQLGLSESKTAADNPEMVGKPHDALFLPDILGPLLDGQKFYRPDSVLAYRLLPHLRPGALFVSGAESGLYEKGHQSEAVKMAGTGFSGSGGQRYSRVKHIVMDKGSHTFPMEMVTQTASYIGPWIAAESERWRRDEQRIAAGWESLSVKERSTIPEDWKVPLSIWKPVDKRSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QW78</accession>
    <name>A0A8G1QW78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_431185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510447.1">
        <property type="nucleotide sequence ID" value="XM_025658327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QW78"/>
    <dbReference type="GeneID" id="37161729"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="1">
        <location>
            <begin position="148"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="590" mass="67737" checksum="7EBF12C08EBB87A6" modified="2022-01-19" version="1">MVRYSYPEWREVQQHTSEGHWRWIPTLGRIRRTARSLGLHIVPNYVDDGEETCSHQQSLAPQVEISEITPQHTSMIQHPERRDDGITEMQEQASVPVPEIVDMTQIDISLCSGGDKVCFWCVQEQILNQKAHKESNTVGSRSRWTDEVPPVIYRWSNIDSQGVNSKMLFLAGLFADGRQFFTPGDISQEEFINYFSRHVHIDKTPSPFISTFRSMLSPVHRALWNKEGAIISIIDTHKLDTDVYPAIKLFREQNLRIRGYDGRGEFLLADEHAEIGQFLQLDKLASHKYNRKQLHGELARDAGKLDHTSGYAIGKFLNSINLPFEFSREVSEGLFHSWRLKRQGTWESFHEGVCAGYDRSIPSTSVSEVRRPESIVHDISDDDSITECGSIAEDENMSDGESEDIGASSPCMGRELAAHTSERKPLSTPDWFFMRDTDDELITDEDGEEEEVTGRQINLFSEQDSNRSAELITDWPEEATQVLSSLNLHISQTRIPTIEIFDPKTGGWVQEQARLAQKMEEDDCQSYMQPPSSDDTQEMRGISVEGESDIMHDTETRYSILSMSRELSEDVLPHIRFVRDRERRRRWLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWP5</accession>
    <name>A0A8G1QWP5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho GDP-dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_490617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512884.1">
        <property type="nucleotide sequence ID" value="XM_025663668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWP5"/>
    <dbReference type="GeneID" id="37167070"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000001">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH54962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="197" mass="22316" checksum="B8748F3EDEF1BC35" modified="2022-01-19" version="1">MTDHEEDLVASQTEGFKVGEKKTIEEYQNLDKNDESLNRWKASLGLATGTPIGDPNDPRKCIIKSLALEVEGRPDVVIDLSTPNALDTLKDKPFKIKEGAVFHIKVVFQVHHEVLSGLKYLQVVKRKGIRVSKDEEMLGSYAPSTTDKPFYEKKFNAEEAPSGMISRGHYNAVSKFVDDDNHTHLHFEWSFDIAKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWQ4</accession>
    <name>A0A8G1QWQ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_66356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513733.1">
        <property type="nucleotide sequence ID" value="XM_025665573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWQ4"/>
    <dbReference type="GeneID" id="37168975"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="471" mass="52500" checksum="AB43A2C7A31D89FF" modified="2022-01-19" version="1">MPGVAITMDVWSSGHGSIHQQAAMNSISTSSIPPGLDPDPLQLSTTSPAMCQPAFPGTLSLHHYRKQLSDSDAFAFDSPEGHILKRKNAAIHLNQTPMYPHHSAHPFSVSSAASSPPPLSPSYSPSAMSEQGPESLRGFALSPNVELHSSDSPIYSRSNPHRLLDTFRDRLEKYPDSNPDQEGSFHKHTRTRSDSILFNMKNRTATVIDHGTSFEIVNPHESLNFARIVSFIEDVDAYSARDSTGHHRESYIETTEERLTISEEDYLRAIAPLSPAPEEDEQKVHEELVGDTPHQPIPSISERLQNKDSEDMESRYSRSPNYTQRRPPPLRPRAWTDESDLGEPGSPIHEDGDYPSPMSYARPSTAPFPSDGQMYPTSPVSPLAGYYDMNLWQGGSPLQDGPGIPHPLYSNPPSPYASPSPFPSPHQTQKIHIHHNISKRSLEKRKKNNKANAGPLNPFKRLYSMFRKKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX12</accession>
    <name>A0A8G1QX12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_503812</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511652.1">
        <property type="nucleotide sequence ID" value="XM_025664256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX12"/>
    <dbReference type="GeneID" id="37167658"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH53730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="702" mass="79184" checksum="E31086072B367AF0" modified="2022-01-19" version="1">MEPHTTSQIHAPRRKRLKIATACLRCRRRKVKCDGVRPACGACRRSHEEADCIYENGAAVREPGLARFSDESRAAPRVPNAPIQPFLEAAKDYAYPGLCSGLGASTAPERTIPSAIHPLQLNRSPSEPHGEDSMNGIIGDPARTREVYGSSSASSFIQQIQTAINFKLGIAHQITGELKAIPRSRSPCPQTSLSNCEEPTLFLLPPKGLADGLIGAYWDNNWALYPVINRRKIETIYDSLWTSPTSANYPLIPMSIINICFAIGCHYSNLLSPKDRMGTSDDFYGRAKRLYQKTGDIPSYERVTCLLLFAIYLQSTKHVFQCWMTVGKAIRMAQSLGVHLPESTIYLESVRDREYKRRIWHCCVWLDRVLSSTLGRPGMIPKWLFNSVPLPSMIDDEFFETQDIGSPIRPDGQPCIMAGAVKAMELYQILDEVLVDLYLNPNDSEDTKRRLIRILEIDSKLQMWNRALPEHLQLGATATRDFLVERQATVLRARFLHARILLFRPALISYCVRGGSTSGTELFDANNSSLAEAMLPECSRICFRVAQELIEIYDRHLSRQNALGPLPNWWYSVLYVYNATMMILVERFLEAKDGIVKDPKAYQAWHAALRVLKCYSMVGDSAKRCVALLEILCERFSLDQPERFSQQQQNEISQDWDSLLAMSNPFTANDAGIPPFSFDDFIWSDAMPAEAMLTDGPIEPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXG1</accession>
    <name>A0A8G1QXG1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_428579</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3"/>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511862.1">
        <property type="nucleotide sequence ID" value="XM_025658210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXG1"/>
    <dbReference type="GeneID" id="37161612"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01401">
        <property type="entry name" value="PncB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.140.10:FF:000014">
        <property type="entry name" value="Nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.140.10:FF:000015">
        <property type="entry name" value="Nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006406">
        <property type="entry name" value="Nic_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="10">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="182"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="336"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH53940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="490" mass="54917" checksum="37659F6807E2F2EE" modified="2022-01-19" version="1">MAQNNTPPLPEGIFSLLDTDLYKLTMQCAVLKYFPDVYVTYGFTNRTPDMKLTRGAYKWLLAQMDAIANIRVTTEEIEFLKKWCPYFNNAYLDYLTNLKLKPSEQIEIHFTPEQDTGSEDDLGNVNYVIKGLWVETILYEIPLLALTSQAYFMFTDKDWDYSCQEDKAFRKGCALLENGCIFSEFGSRRRRDYHTHDLVMQGLMQAAEEGKKQGWKGVFTGTSNVHFAMKYGVAPVGTVAHEWYMTIAAITDDYENANEMALRYWLGCFGEGVLGVALTDTFGTPAFLDAFRKPIPAFTSAGVGAVSTTASGPGTTTESTVQSEATTKPPIAAPLVNDAQGEHANKTYAQVYTGVRQDSGDPTYFVKMVRDFYDREGVKDPKTIVFSDSLDIEHCLEYKVIAEEAGFKPVFGVGTFFTNDFTNKSDGQKSKPLNIVIKIATANGRPAVKLSDNMGKNTGDKETVQSVKKKLGYIEHQWEEGDESNRWARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXS8</accession>
    <name>A0A8G1QXS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_48814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514288.1">
        <property type="nucleotide sequence ID" value="XM_025663508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXS8"/>
    <dbReference type="GeneID" id="37166910"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF156">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH56366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="482" mass="53607" checksum="BABAFFA68FD9FC04" modified="2022-01-19" version="1">MAHLENLQGLIAQSLSLVVLALSSAIFCKCFYRIYLHPLSSVPGPKLAACTSLWLAYHTYIGDECTVVYDLHRTYGSVLRVAPNDVDIADKDALEPIYVARGGFPKTPAYSKFDIDGHTTIFSSLTLPERATRAKAVAPLFSTASIRNSQEALREVFDDFAKRLQAEARTGRPVNVLNVTRAMAIDAVSTYLFHERYGAITEDSKSMSASPFVDSFVGVGAYFNIVPGKIGGFVTEVIERWSTTKNVEQSHGLIDQYARRLVRAAVPKSGSYQSRLLVKSTIAQSQIEVKDVCFAGTDSTGMNTATIMWYLAKHPEVYDRLRQAVMESIKNDEDPTACAYLRGVVREGLRLSWANPIRLPRSVPAGGWKYRDYYFPAGTSVGVAAFQLHQDSSVFPEPHRFLPERWDNADDEMLTAFFAFGKGTRACIAQSLAMYEVTMAVFTVVKEDVLRGASIVEDRIEIKEWFNSKVKGHEILIQFASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYG6</accession>
    <name>A0A8G1QYG6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_377111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513104.1">
        <property type="nucleotide sequence ID" value="XM_025656250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYG6"/>
    <dbReference type="GeneID" id="37159652"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE ACA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="216" mass="24064" checksum="43ECAEC3DD41E82A" modified="2022-01-19" version="1">MPALLEDPTTTIPPPLPNPSHLPPIQRTLRDNTRITLYPITTGPDTLPSSLLHYLHREFSEEILKGCTYPMESPLEYDLYRTYWFGTFAVVAVVDDDESGNGLREGRDWERVCLGTFYVKPNYPGRCSHVCNAGFFTTPAARNRGVGRVMGEAYLEVAPKLGYKYSVFNLVFENNVASVKIWENLGFQVIGRVPGAARLANSPDLVDALIIGKSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYH4</accession>
    <name>A0A8G1QYH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_451831</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512866.1">
        <property type="nucleotide sequence ID" value="XM_025660681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYH4"/>
    <dbReference type="GeneID" id="37164083"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="73"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH54944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="117" mass="13361" checksum="F1A0F5AC88A10CA9" modified="2022-01-19" version="1">MPLTFCPNCSNALTISRAEPTTRHPLGVNRFECRTCPYQYALDQSWFEKTPMKQKEVEDVFGGKEEFANADSVATQCPAEDCNGDRAYFFQLQIRSADEPMTTFLKCTTCGARWREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ94</accession>
    <name>A0A8G1QZ94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_522294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512807.1">
        <property type="nucleotide sequence ID" value="XM_025665253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ94"/>
    <dbReference type="GeneID" id="37168655"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="362" mass="41884" checksum="C2A06297B624901F" modified="2022-01-19" version="1">MAGVTIDRRTGQAYREMAFHPSKYPNRPFWVHESPFLPERWEESSRVGAPSLQHSAMKCLLSDQRRLRPEIFAYVPWHIASYLWDCLGKSKRRTLHSWKLFAMAYPEQFREVNRYRSYSVKSVEMGMPEYWKEVKSETLSWRVVLSLDPSIARVPDLVEIASIRNLVALEISSPPQTWHNGESSGVTLSNRIIRSWNELQQSSGAFAHLRVLVLSRQCDLTVQIFQYLRDFPSLEIVLAADCGDLTKASKVDFQVDGWLVDPDTKRDGTLYDQYLSVIKSEAKKPTGLDTAPVLNFAINPSKTKSDTPMRKEQVCFYRDGSKTYKHEQESDRKRPRGYPQMKIQRPDKYRKIGWEGLLGDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZW7</accession>
    <name>A0A8G1QZW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fungal STAND N-terminal Goodbye domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_398810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514549.1">
        <property type="nucleotide sequence ID" value="XM_025657068.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37160470"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031350">
        <property type="entry name" value="Goodbye_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17109">
        <property type="entry name" value="Goodbye"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fungal STAND N-terminal Goodbye" evidence="3">
        <location>
            <begin position="135"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="348"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH56627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1386" mass="156338" checksum="CE752FCAB7E8C2C2" modified="2022-01-19" version="1">MAIFGKLRRKKVIPLEQPVGKDQTEDIPPNTTVAEQPRSMLPAPLSEKQEQPKPLQSQSTPRSRQPNGHPTDGAEVPGNNGFNIVAKPMEMPVDDEYTQALLDAHNMVKELAKAQMRPIDGSLGIADVLKNLNEAPSSRKDKVWNGFQHVLGAIQKIGGAAASVASKVFAPAADCYNVVNFVIDTFKGYQGAFDALDNLFDQCADYLTRLDYYEGRMDKNLSNLCAQLLKLFVQVCKRALDLKGSIGGKLKLFGRVMFLNDNGISSLLNEMDKLTNKEKLLVLAQTFKNAHDGYRATMRVEGLVSERHALDMEVNREKVIIKALALACEPTPTWRSRYRELLNQRLPDTGQWIMTEPVFTNWENGQSQANILAIEGGSGSGKSFLASAIIHHLHRKSAKETGHRVSTAYYFFEGTGRQAVKNAMNLETPAKSIVWQFTQMERLYKKSVARIYLHEMNVQFYIVIDGLTGEMGEGMLRFLRRASALQPGRRVLILLTVDAQCSQHLANIEGISFDSIPISPKNRPDVETLIRWRMDSMPAFRDATRPQTSQLRKKVCDELYQATEGDYFKINLALDDISKREYKSEIEHALTNARKGRTTQVRNEIEVLNKHCSETEILEINEIILWIQRYREPLTVKAMTAALYAKVGELSLLTLPDKIKYKYTLFKITKGEVQFRADEVGDTIPMKCRSQSKAEEAEDEQLQSAGAETYNKLEIDRFFEQEKQIRDKELIYKDDPNTEEAKMALSCLRLLAEGVDQQSDLVSYARSNLVEHLSAVNLSLVQVDYKTTFGPYLVSLFSVDSSIDTLLNNNGLSGPSPDERRRVRQLLLNDASMDIILQWLNDEAVILNVNDEARGWITGPVRTEGHRALLMPAAMRMARHLVHEPHFVPFIKHAFEFLAGFLDKYENPSEQEKLESISRIVSVERWCEKVLKGPKNALWHTQIGILLSSHGHKELAEARARQALALNGADWQASTLLAEVVGGSQGIETLKPAIERLVSSGEWKQSALERVGLAKMLFITAELSWKEGQADMAIRYWSRAVDTDLTDIVRVIRCLESYAQGKRWVELIAILRKIDEGSTEQQGLSDLIAARRFPHDMFLQAALHTRELAFAVGAYERSVQLVEERGGHATLSLLRYRFGRTIKAQQDGLSRAIKQWRQALDGADPSDMSTLISCIAPNYVQKAIAAGPNHEAVSAYLEKIEALLPEDVPEAEVSLPPRVYIARYYKKQGNPTEAKRIARNVVQLSLEILSDDDEGNDLPAYNQLLSIFIAFGDIKNILATRALVALHFMEQKIACDGDCNRVMDITEEIQWCQDCILVHLDEECRRKLEQNRLPYSTCNASHDLLRIPRMEESLGNLPEDSVPFGDDWVSFTDWLGHIEKDYVSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R141</accession>
    <name>A0A8G1R141_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_301094</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515381.1">
        <property type="nucleotide sequence ID" value="XM_025655346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R141"/>
    <dbReference type="GeneID" id="37158748"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13311">
        <property type="entry name" value="PH_Slm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043453">
        <property type="entry name" value="Slm1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF1">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="315"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="456"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH57459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="508" mass="55391" checksum="C1B29B130640F034" modified="2022-01-19" version="1">MSTPVSPVEHKLPQRSGTVTSAMTGVSRRTSMSDDEAIPGSDSNETTNLLLERLRAWKHMCGYLEEYVSATAKVSKSQSKDFEKVLKTVNEPLRESHHFSQSAGGVASWFENIRANTQGMVNLYLDSERNLKGSVLPTLERLHKEIKAKSKELQNGAAKGAKAVDKARGVTQKHIELLAQHTATLDAASHNKIDTAHDPYILRRGVTHRLNKQVIEENNNRQDLIAVQNNFQQFEAHVLQTVQGAMEQFVVYMGGQLDRHRAMYTDILSSAQKVPPDFEWVNFMTRNDHILVNPDAPPRSLSNITFPNQEHRATKPLIEGTLERKSRAMLKGYSSGFYVVTPARYLHEFKDNDDLRRDPAPELSLYLPDCIIGAIDGSKFSVKGKDVSSGKVGNAFHTNTELSFKAANSNEAEKWWTVIKDATRAPTFASSTTTSPTSPVAAESSQPPAYVEKESAAAPPQEAATAPSPTTPAAVSRTNTSGSGTLPTASGAAAPAAAPATTATEDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1M4</accession>
    <name>A0A8G1R1M4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_448846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515666.1">
        <property type="nucleotide sequence ID" value="XM_025660036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1M4"/>
    <dbReference type="GeneID" id="37163438"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="55" mass="6165" checksum="0E6B4B428836448A" modified="2022-01-19" version="1">MTLPAQQVLLLVRVDDDGIRFAASLWGAHTVFVRPLRLVRSMCLTRCNQVHSGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R242</accession>
    <name>A0A8G1R242_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Protoheme IX farnesyltransferase, mitochondrial</fullName>
            <ecNumber evidence="12">2.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_469181</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Converts protoheme IX and farnesyl diphosphate to heme O.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515024.1">
        <property type="nucleotide sequence ID" value="XM_025662317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R242"/>
    <dbReference type="GeneID" id="37165719"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016315">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001773">
        <property type="entry name" value="COX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="407"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="71"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH57102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="525" mass="57034" checksum="0EE5B7F7E0CD39D2" modified="2022-01-19" version="1">MSLLRSSLRRIGSPGDPSRICSQCLLHRNRTPRTFPAALRTFSSSFRSHSGIADGHSAQSALNKTYFSANRAEDGTPSKSDIVSSLSGGNVSSSATSSTLPSDHRVNASTSAPDSTQPELPHRRRKRLKEEANAQAADPEHVIPPDASAQLSAFSSAQPTSSLRRKMAAFLALCKPRLSVLIVLSTTSAYGLYPISSLLTLDPSMTPLPTLSTSTLTFLYLTAGTFLSSCSANTINMFLEPKYDALMSRTRNRPLVRGLLSRRAAALFALATALTGVGMLYFGTNPTVAALSASNIILYGFIYTPLKRIHVINTWVGAIVGGIPPLMGWVAAAGQTATTGHDTWRDMLFSQDSIGGWLLGGILFAWQFPHFNALSHTIREEYKRAGYKMLCWKNPAMNARVALRYSVLMFPISIGLWWVGVVGHGFLVSSSVANAWLVKEAYHFWKHQGANGTARGLFWASIWQLPVLLVGGLVTKKGLWDGVWRQIFGQPDELDDEYVYVDEEEEGTGAAMAASRSKSVATRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R276</accession>
    <name>A0A8G1R276_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">C2H2 type zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_279316</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516598.1">
        <property type="nucleotide sequence ID" value="XM_025655177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R276"/>
    <dbReference type="GeneID" id="37158579"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="717"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH58676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="847" mass="94185" checksum="7285B3BA0601137B" modified="2022-01-19" version="1">MVLRKCTICDRRFKKTEHFKRHERSHTKEKPYECTVCHKRFSRSDVLSRHARGHNQPAANAVVGPGAGIPATPTNQAPAHRPSTMTAGNQNYVLNMGAESARPLQHGSSAPHNFTLSAALDQQSTSLDFLANVSAHQPRTEPVANHIMANEHQGYLGWNDVSVPDQQCYRGTVLDPLHNDILQFWLEPQGDSISQQGSIDLRGSSNFGMLGEAVASSEQPRQSIDSMSLSTGSSIPTERFARVQRYWLAPSNNTGRLMNSLWHDVAYSDQDNVFSFRPTHSSSAPSGYLQGSRYGVDEECRQRLYRMFNQIQGQSQMRSSEATAVSPFTQPHRNSNFPPAEILDMALDLFFRDFHPLVPFIHIPTFSAKDARPSLLYAMCLIGMVLLGTKGTLSFVVNNFSSMLGSITADLAKCSVGVEGSMFTVSTFAAAFLLLNLAAMTGEKEHLEMCQMLYVNLISIAQRHGLFAAREGQVLDTHLFDAVPNTEARWKAWSKVESVKRLITGLLLLDSWYSSFMSTSPIIVPDSVQLILPCDEALFRAPSSPRWMQLSGSDKVSLMPTILMPSENVDIPTLRSPIDDFCMYAVLAMVQSRLSEAYYRLLSNRASYPFAPCNTYAMDGRARCLPSLQLQLTSKYGDVLDRLNPNAAVMWHNMCMTLTADTQIFDMAAGRSGPGPARKALDDIAAWSQTPSARRACLHAAHIYRAMTNRKASDHTMFHSVFSLFYAALVLGLYVFMVPSTSEMQQGGHSIELFDDIDWQKVGTEGFTSFKEPREGQPFPPSEEAALNFIRNGGTIYLRGVPIQGGYQAARRVLLDYAGLLKDTGKWSVRKFSYVLHIMSDVLMDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3H7</accession>
    <name>A0A8G1R3H7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_419313</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516500.1">
        <property type="nucleotide sequence ID" value="XM_025657856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3H7"/>
    <dbReference type="GeneID" id="37161258"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="10">
        <location>
            <begin position="6"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH58578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="454" mass="49791" checksum="86A3E07C070111FB" modified="2022-01-19" version="1">MSVPNITTISPITNRPILNRTGANPEDIVGIAESAQSAYRSFSTSTTLKQRQDIVTRALAKLEKRKDDLARQLTEQMGRPISYTGIEVATAIKRSHYLNRISDSVLGEEGIVPGEEETGFKRYIKRKPVGVVLIIFAWNYPYLVLVNSLIPAILAGNAVILKPSPQTPTVAEEVANAFHEAGLPEKALHCVNHICFTGSVEGGLATQKAASDRIVNVGLELGGKDPAYVRDDVDVAWAAGEIVDGAIFNSGQSCCAIERVYVHQGIYEEFVAEVKKVLSGYVVGDPFDKKTQIGPVISKRAKEDIEAHVADAVEKGAKDETPENESFENPPSEGNYVRPTLLTGVTHEMRVMTEETFGPVIPVMKVEGDEEAVKWMNCSEFGLTASVWTKDVKAAEELMEKVEAGTVFVNRSDYPSPDLAWTGWKNSGRGVTLGRFGFEQFVKLKSYHIKDYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3K9</accession>
    <name>A0A8G1R3K9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_371804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515789.1">
        <property type="nucleotide sequence ID" value="XM_025656011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3K9"/>
    <dbReference type="GeneID" id="37159413"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.30:FF:000004">
        <property type="entry name" value="Exocyst complex component SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.670:FF:000004">
        <property type="entry name" value="Exocyst complex component SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="3">
        <location>
            <begin position="51"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="2">
        <location>
            <begin position="402"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH57867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="767" mass="87756" checksum="B1C67E434776D25B" modified="2022-01-19" version="1">MPSVAPSRNESSYLLNQLIISPSDADYIDQLIPSIKEYSVGNRTSQLSQTLSRFASDKEAEIETICNTNHQEFVTSVNQLLRIREGTVSLTAEILDLNQSIQASTEKLAEQKRALVESRSHRQNIDETSRAIQDCLEVLRLANQVHDLLAKKNHYAALRALEELQNVHLKGVTQYKIADMIQRSVPTTQKAIAEAVMSDLNTWLYRIREMSQYLGEIALYHTDLRKTRHKERTEISPYLGQFKLNSAIELVSDESEEYDLLQNEELQVDFTPLFECLHIHRSLGHMDRFRVEYANTRRRQKELLLPASITLVDEDGASLHNLLEEMAGFAIVERSTMKRVPDLRSSVDVDELWDSMCQTAVILISGALHEVDNAESLLKIKNLIALFMQTMNTWDFHVGVFDDFLLILFRKYADLLKKRFSDDFREIVSTDDYMPMPIQTIEEFDKVLNVSWYSPGKPREEQVFPCVLPFSQMYPLCCIDIRNFLNQFYFFANDDFSHPSLIDETLRDALDELLSDKVCDTLVERLSSQYLGQIVQILINLEHFELACRELELLLAAARSQNVSGDVVTLNATEKFRSNKKAAEKRIFEVVNSKIDDLIETAEYDWMASVPPAEPSNYMQTLTRFLSNIMNSTLLGLPTEIKELIYFDALSHAANMILALPLSPEVKRINPNGVMALAKDVEYLSQFVDGLGVPILRENLDELQQTVQLMQADNTDEFYDISTRNKKYGRVDAIHGPVLLEKCVTNHHSLDTITNQQEGSYVPFKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3W5</accession>
    <name>A0A8G1R3W5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione synthetase</fullName>
            <shortName evidence="10">GSH-S</shortName>
            <ecNumber evidence="10">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_448876</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10 12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="10"/>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515701.1">
        <property type="nucleotide sequence ID" value="XM_025660043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3W5"/>
    <dbReference type="GeneID" id="37163445"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R425</accession>
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        </submittedName>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
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        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RAH58802.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    </gene>
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Theobald S."/>
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                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
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                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <text evidence="4">Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.</text>
    </comment>
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        <text evidence="1">Belongs to the SUI1 family.</text>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH58167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="114" mass="13068" checksum="BDD5D2ABA1D84AC6" modified="2022-01-19" version="1">MSIENLKTFDPFAEADEDTGETKQSQNYIHIRIQQRNGRKTLTTVQGLPKKFDQKKILKVIKKKFACNGTIVNDTEMGEVIQLQGDQRKDVQEFLTDKKEGLELDAKTIKVHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4H1</accession>
    <name>A0A8G1R4H1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RuvB-like helicase</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_477732</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516031.1">
        <property type="nucleotide sequence ID" value="XM_025662847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4H1"/>
    <dbReference type="GeneID" id="37166249"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="63"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH58109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="458" mass="49760" checksum="CC6F772B66891AF6" modified="2022-01-19" version="1">MVQISEVKGNSRENRTAAHTHIKGLGLRQDGTAEASGDGFVGQATAREACGVVVDLIKAKKMAGRAVLLAGGPGTGKTALALAVSQELGTKVPFCPIVGSEIYSAEVKKTEALMENFRRAIGLRVRETKEVYEGEVTELTPEETENPLGGYGRTISHLIIGLKSAKGTKKLRLDPSIYEAIQKERVTVGDVIYIEANTGACKRVGRSDAYATEFDLEAEEYVPVPKGEVHKKKEIVQDVTLHDLDMANARPQGGQDVMSMMGQLMKPKKTEITEKLRQEINKVVNRYIDQGVAELVPGVLFIDEVHMLDIECFTYLNRALESSISPIVILASNRGNTVIRGTDDISAAHGIPPDLLARLLIIPTHPYSPDEIKTIIRLRAKTEGLSITDPALDKVSGHGSKVSLRYALQLLTPASILAKVNGRPGGIEEADVAECEDLFLDARRSATIVNQDSEKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4I5</accession>
    <name>A0A8G1R4I5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_448307</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517335.1">
        <property type="nucleotide sequence ID" value="XM_025659909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4I5"/>
    <dbReference type="GeneID" id="37163311"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05652">
        <property type="entry name" value="M20_ArgE_DapE-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF8">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034202687" evidence="7">
        <location>
            <begin position="17"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="8">
        <location>
            <begin position="213"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH59413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="416" mass="43644" checksum="3C036F1616FE5318" modified="2022-01-19" version="1">MKSPISLLAAVGVASAASPQTLLSLASTASDIIDTSPFLSFHRDIVQIPSVSGNETAVGTFVAEFLESHNFTVIKQPVPSSSKGDPDRFNIFAFPSTSPSQDRPEILLTSHIDTVPPFIPYGLHDDANNNSNILISGRGTVDAKASVAAQIFAVLDTLESNPSASLGLLFVVDEEVGGLGMRTFSDNSTLNPSPSPYHTVIFGEPTEQALVAGHKGMLEFPIIATGQAAHSGYPWLGSSAISALLPALSRVDHLGKIPEAEGGLPASDKYGETTVNIGRVDAGVAANVVPSSAIAEVAIRLAAGTPDEARDIVARAVRNATGGDEHVYCDFAAYAGGYAPQDLDTDVPGFEITTVNYGTDVPNLKVSEGVKRYLYGPGSIHVAHGDNEAITVGQLEEAVRGYKRLIEAAVQRARRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4K1</accession>
    <name>A0A8G1R4K1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_261849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517070.1">
        <property type="nucleotide sequence ID" value="XM_025655032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4K1"/>
    <dbReference type="GeneID" id="37158434"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="147" mass="16483" checksum="F604FF7F93EDB499" modified="2022-01-19" version="1">MENKTEDKKKQRRGGETGKSNEEEEETEKINDFVRAGMERSKDDDPTENNLLNEVGEEGEREGGRKWKFKKTNEMPPIQLCAAPLSATIATLLGASRESISFLTPFRLMIGELVRLRMESSSPTTSQSVSARHFPTQLPLDEGGVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4P8</accession>
    <name>A0A8G1R4P8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_448181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517145.1">
        <property type="nucleotide sequence ID" value="XM_025659881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4P8"/>
    <dbReference type="GeneID" id="37163283"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="59" mass="6572" checksum="9E6706E976B79677" modified="2022-01-19" version="1">MSTHEAQPHGHTLPLSKNSWSGYSVGGGTIHRTKIRGCWSQELDGIRLLIPSTWQWKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4U5</accession>
    <name>A0A8G1R4U5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Cutinase</fullName>
            <ecNumber evidence="3 12">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_416677</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 12"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517421.1">
        <property type="nucleotide sequence ID" value="XM_025657744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4U5"/>
    <dbReference type="GeneID" id="37161146"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034979320" description="Cutinase" evidence="14">
        <location>
            <begin position="16"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="41"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="120"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="249"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH59499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="288" mass="28613" checksum="9B8F9536D5C2B96F" modified="2022-01-19" version="1">MKSFITLSLLATALGAPTSTLQARQFDLSSLTSGLSALTSGSAASSSSGSTGSTGTGSETTTGSSGLSALASLFPSSSTSSTTGSTSGTSDSSSSDGLSSLLSIKGSSTENGVTQHSGSCKKLTFIFARGTTEIGNMGTVVGPEVASELASLTGNQVTVQGVNYPADWEGNVSLGSSGGPTMASYVKEALQQCPNTKVVLGGYSQGSMVVHYAANQLSADQLSGAVLFGDPLKMEGVGKLSSSKVKEFCASGDPVCENGVNVMAHLTYGSDAKEAAQFLVQAAGVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4X0</accession>
    <name>A0A8G1R4X0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_447506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517545.1">
        <property type="nucleotide sequence ID" value="XM_025659740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4X0"/>
    <dbReference type="GeneID" id="37163142"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010658">
        <property type="entry name" value="Nodulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06813">
        <property type="entry name" value="Nodulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Nodulin-like" evidence="7">
        <location>
            <begin position="13"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH59623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="546" mass="58996" checksum="8527E3E29B2C6360" modified="2022-01-19" version="1">MAAASPNKSKRIVSVVAATLVALACGTNYAYSAWAPQFAQQMKISSTESNFIGAAGNLGMYASGIPLGLLTDARGPRLTTFLGAITLGIGYYPIYLAYVKGPGSMAIIFLSFFAFLTGFGSCSAFSASIKTSASNFPDHRGTATAFPLAAFGLSAFFWSTVSSVLFKDDTGRFLLLLALGTCALNLVSIPFLRILPPSEPYMPLGRGRSPGVESQRLRTTRSTEFRHSLEESDEAGTQTFITYESCPAARDTSHSVVSSPHHPGHSPDIDETSSLVSKVPSRSSRDFLNQHEEDDDALSDVAPESPHPDVRGLAMLPKIEFWQLFLTMALLSGIGLMTINNIGNSAKALWQYYDDSASPKFIQQRQVMHVSILSFGNFIGRLSSGIGSDLLVKKLNMSRFWCLFISAFVFTVTQLAGSAISNPHQLAVVSGFTGIAYGFLFGVFPSLVAHTFGIGGLSQNWGVMTLAPVFSGNVFNLLYGSIYDRHSIVEPNGDRDCPDGLACYQSAYYTTFLSGVAGVVVCLWSILHERRIHGAMHKKVEHDRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R512</accession>
    <name>A0A8G1R512_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_447491</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="12"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517526.1">
        <property type="nucleotide sequence ID" value="XM_025659735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R512"/>
    <dbReference type="GeneID" id="37163137"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000004">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="343"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH59604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="387" mass="42797" checksum="5B18716B3E3DC089" modified="2022-01-19" version="1">MANLTADQRLALITENLQEVLNKDIIEAILAEGRSPKIYWGTSPTGKPHCGYLVPAVKIAQFLAAGAEMTILIADLHANLDSLKSTFEIVEHRAKYYEYTITALLQAVGVSTEKLRFVRGSSYQKNADYVMDVYRLSSVVSEHDAKRAGAEIVKQSNNGPLSGLLYPLLQVLDEQYLDVDAQFGGLDQRKLFAASTEWHPKLGYKKRAHLCNAMVPGLSGGKMSSSEEDSKIDLLESIDSIKKKIRKAQAAPKEIDNNGILAFVQYVLLPVSALKTGKPEFRVPRDRDGLEPLVYTDIEKMHEDYKNDILSPQILKPAVADAIVELTAPIRAAFDANPDWQEVTLKAYPPPAPKQKKEKKQKDKGSRHPGAAKEQTPNGEPPKPAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R535</accession>
    <name>A0A8G1R535_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_370569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516316.1">
        <property type="nucleotide sequence ID" value="XM_025655966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R535"/>
    <dbReference type="GeneID" id="37159368"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="256"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
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        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="372" mass="40008" checksum="BA995766E3D45A41" modified="2022-01-19" version="1">MEYPPQYQQPHGQHPHASSHITAPYQTAPQNAGSTVGSMTSPTNPQAHMQQAHATHQASPIVPSQSHYQPAQNAPGSVHQQMNFPQSYGVTTAMPQTYGISPTQAAAMATAAASGQFYPLHQDSMAGQMAPGPRGSPRMAGVQVKSDRNPRSPPQIPGQMPSMGSQVQMSQNAQMQQRRMSHVSSPHVQNAQPLINHAGRPSVPPSMPPPPQPPVQQSQPSPDMVAGAAEESPLYVNAKQFHRILKRRVARQKLEEQLRLTSKGRKPYLHESRHNHAMRRPRGPGGRFLTADEVAAMEKKQASGSTTSGLEAADDNAVKPPGDNPPSAQKRKSSDVNDDTINSSKKTKTSAKPSTSADESENESAELSDEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R586</accession>
    <name>A0A8G1R586_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_488515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514947.1">
        <property type="nucleotide sequence ID" value="XM_025663538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R586"/>
    <dbReference type="GeneID" id="37166940"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="140" mass="15258" checksum="2CF82673F94ADB8A" modified="2022-01-19" version="1">MPTPLDRALNSKNLFLGFAGMVTAAAAWAIWGGDMFPAEADPTGGTGSNSSVVIRKTGLQMKCGHGFELGAFCPAKAHRVTSYSSALKQICVYREDLRPSDEIAVALFREFFAWRVVGYFLGFPSIFLLRLKMCNRVVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5B0</accession>
    <name>A0A8G1R5B0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_415617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518278.1">
        <property type="nucleotide sequence ID" value="XM_025657699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5B0"/>
    <dbReference type="GeneID" id="37161101"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF27">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH60356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="276" mass="31321" checksum="BAC0A3093260E1F6" modified="2022-01-19" version="1">MAKLEPYVPGYYLWSYMPSIAAAAIFLVLFLGATGIHFFKLFRSRAWFNIPLAIGGIFEFIGFIARIISHFHTAELGPYSMQSVLILLAPVLFAASVYMTLGRIIRSVDAEQYSIISLRWLTRVFVTSDVLAFLIQGNGAGLQAVESMQTFSKIIVIVGLIFQVGMFVFFIIVSVVFHKRMQRRPISGAQSPWKYHMHTLFAVSGLILVRSIYRVVEYVMGYDGYLLTHEWPLYVFDCVLMWLVMVIWAARYPGDIQTGKPEMELLVTRSDDGTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5C7</accession>
    <name>A0A8G1R5C7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Maltase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_468644</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolyzes malto-oligosaccharides, but has a low activity toward soluble starch.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515957.1">
        <property type="nucleotide sequence ID" value="XM_025662281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5C7"/>
    <dbReference type="SMR" id="A0A8G1R5C7"/>
    <dbReference type="GeneID" id="37165683"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000001">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000005">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1760:FF:000005">
        <property type="entry name" value="Putative alpha-glucosidase AgdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000138">
        <property type="entry name" value="Putative alpha-glucosidase AgdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000169">
        <property type="entry name" value="Putative alpha-glucosidase AgdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034469506" description="Alpha-glucosidase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="14">
        <location>
            <begin position="134"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="13">
        <location>
            <begin position="328"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="15">
        <location>
            <begin position="765"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH58035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="987" mass="108919" checksum="248C9D4F053C3CAB" modified="2022-01-19" version="1">MVKLTDLLARAWLVPLAYGASQSLLSTTTSSQPQFTIPASADVGAQLIANIDDPQAANAQSVCPGYKASKVQHNSRGFIASLQLAGKPCNVYGTDVDSLTLSVEYQDSDRLNVQILPTHVDSTNASWYFLSENLVPRPKASLNASVSDSDFSVSWSNEPSFNFKVIRKATGDALFSTEGTVLVYEDQFIEFVTALPEEYNLYGLGEHITQFRLQRDANLTIYPSDDGTPIDKNIYGQHPFYLDTRYYKGDRQNGSYVPVKSSETDASQEYISLSHGVFLRNSHGLEILLRPQKLIWRTLGGGIDLTFYSGPNPADVTRQYLTSTVGLPAMQQYSTLGFHQCRWGYNNWSDLADVVANFEKFEIPLEYIWTDIDYMHGYRNFDNDQNRFSYSEGDEFLSKLHESGRYYVPIVDAALYIPNPENASDAYATYDRGAADDVFLKNPDGSLYIGAVWPGYTVFPDWHHPKAVDFWANELVIWSKKVAFDGVWYDMSEVSSFCVGSCGTGNLTLNPAHPSFLLPGEPGDIIYDYPEAFNITNATEAASASAGASSQAAATATATSASTSVSYLRTTPTPGVRNVEHPPYVINHDQEGHDLSVHAVSPNATHVDGVEEYDVHGLYGHQGLNATYHGLLEVWSHERRPFIIGRSTFAGSGKWAGHWGGDNYSKWWSMYYSISQALSFSLFGIPMFGADTCGFTGNSDEELCNRWMQLSAFFPFYRNHNELSTIPQEPYRWASVIEATKSAMRIRYAILPYFYTLFDLAHTTGSTVMRALSWEFPNDPTLAAVETQFMVGPAIMVIPVLEPLVNTVKGVFPGVGHGEVWYDWYTQAAVDAKPGVNTTISAPLGHIPVYVRGGNILPMQEPALTTREARQTPWALLAALGSNGTASGQLYLDDGESIYPNATLRVGFTASRSSLRSSAQGNWKERNPLANVTVLGVNKEPSAVTLNGKTVSPGSITYNSTSQVLFVGGLQNLTNSGAWAKNWVLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5G1</accession>
    <name>A0A8G1R5G1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_422081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515067.1">
        <property type="nucleotide sequence ID" value="XM_025657957.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37161359"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17716">
        <property type="entry name" value="BRCT_microcephalin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022047">
        <property type="entry name" value="Microcephalin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625:SF3">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="1489"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="931"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1610"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1163"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1201"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1401"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1437"/>
            <end position="1452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1769" mass="193457" checksum="86F5349B3E7E5A2C" modified="2022-01-19" version="1">MARAAVIPQSPPKRTTRTRTKGSTTTTSAKAAPKTTKARAPSSATEARKRGGRTTAAASRPADEDADESTDDEIGMFSERKTTTVARPKGRPTTKSTTTTASRGRKATPTTNAESGSDNDDELAQSDAPKKRAGRPRTKPATPAKTETVPKTRGRPKGSTATKSAKPVDPVKENTRLNAKGFTDIDFSSSQEAPKRVYIATNSTTARSNMLRGPAKKKKVTFQDPSETAEEDMSEPSPPPAAGRRRGTIGPGRQAGLASKPVRKPAATSAKGRKPATAKKEGPKPLSPKKATQVAKALSSYADSDGEEDELSGDKDQVKFVVNSPPKHGSENTGLSSPVKKINITGKFRKSLDENGEPLPGPRRSIDFNDTLLMSSPARRPPPSPFNFSMRETPKRGAFAPRDDPKSLSQPHLSPTHNSPLKLSPRKAHLETPKRGSVFLDSGKPLSQPNFTPGHNSPLKASPRKGLFGVSFTSQAHAESTSTPLRHSVSFLQSPAKRIASPFKSSLFASRSPITEDVQVDTRDVEEPATPDVDESPLRMTEFQEVRDAESDDEQVDGDIPEGVEDNDATKEIDTKSPAAAEESDEDTLHEEFDREQTIEYEEEYMGNAAEDVTTHEEHIESDVPNDQQVEEPAHELIEATEEPMEESEEEFRDDAMEEPADELVESPEEPIKEPNNEPMEEPMEEYTEEMAEESVSDPTEHIDEPVEEPMEEHADESVEPPMEETEESVEAGVTEHAEESSEPPIKELVTEPDAELVREPEAEQTHPTVEDEETGGMSNVHEAQENATEYAEDSPELDAEVSVPDTREDTVEMEDISVSLPKDFSPSNRSETRESVVEEEPSAGYDQGDVEQPEHEAEERTETTDPATETAPGSANIGLRSSLIEGLEDVFVERAAPPEPVNDDRGGSETEDDPDMLEAADEENAADAFDDFDDVDDQYTFDDSEPTLVGFEPTERIPPNLVPIQPYEVEEAEDPFSPSRQAQNASKRVLSPVRILESPIRRSPIRRSARNAPTPAATMDNGTQNNADLSDPFVEHSRATPRRSTRGLLFDNAPRFTPLAQQFRQWKSNSPEKAQATRPRRGIFSLGGRRRSSNVTSTSEVSYPDVSRQAEASSSKPQTSQQEREDVDVPEVAGIEEQEPEENAEPAHEETPMPVSPAAQEQSEDVDVPEYDEDQEQEAEPIAEEPNQPSSAELPTPQEDLNDVDMSLPEEQDQDPEPVDEEPSPEQASLPNSPILEEDSNDADMPAIHEDEPSQPTGDMPSQMEALPAEPDTLQETDKSADIPEIYEDEDSGSQQAGDTETFEEPLERSAEVVESSQEAVADASEDKENMYAVPSVPDNLASESQPDKERELGDIPILAPSTPMKNRIPEMQTVHTVSKVPLKPEGQISPLKMSRKRGLSLSASSPGRSSRPRMSAIAPVARNAPQLSPRKSPRLQRTASRQSLGQSHTPDTARKPIEAQRPAPPKRPSYSPSPKKKTKAPRTSINAPKLALQGSVVYVDVHTTEGEDASGIFIELLQQMGARCVKNWSWNPRASVSPEEGTEPKEGKVGITHVVYKDGGVRTLEKVRHARGLVKCVGVGWVLDCERENKWLDEAHYEVDLSIIPRGGAKRRKSMEPRALSNVNGTLVKTDAASASANRRRSSLAPPKESIPRDATPSSRDEPSTPDATPKIGAGHTEADQQYCHTPKTPGYTLDMDAIGMSPATPFYLSQRTKLVQQTCPPKQTRQGLFTTPAAAREPNQKLRAKLEAARRKSMAYKPRVGSPLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5K9</accession>
    <name>A0A8G1R5K9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nonribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_510458</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025664549.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37167951"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904091">
        <property type="term" value="F:non-ribosomal peptide synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000002">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="574"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1633"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2700"/>
            <end position="2776"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="4223"/>
            <end position="4299"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="5316"/>
            <end position="5392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH59627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="5834" mass="642095" checksum="1064B45CB7EA0A83" modified="2022-01-19" version="1">[encoded data, 5834 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5V1</accession>
    <name>A0A8G1R5V1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Werner helicase interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_459437</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515277.1">
        <property type="nucleotide sequence ID" value="XM_025661657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5V1"/>
    <dbReference type="GeneID" id="37165059"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="139"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH57355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="503" mass="56142" checksum="370348AB5E9E0ADA" modified="2022-01-19" version="1">MIRCPICQEHVLLSKINEHLDSSCQRFIANTHLQNTTSSSLIDNGSNSQERTKQLQLKDGYGSTESFAAGTGGLKRAVPQPQSTIARKKPYIESATERLRLQTAPLAEQVRPRCFDDIVGQDSLIGPNGTLSRLIEQDKLPNMILWGPPGSGKTTIARIIGRMMRRKYKDIVTKATQDVRKGQKPSIVFCDEIHRLTRPQQDIFLDAVQRNKISLIGATTENPSLNIHHTLVYKCKVFSVTKPTTNDLVTILRRSVESQTHMKSSPLLDDEFLQYIAGFADGDSRIALNVLEIATDLCTCPGMTKEKLKQSLTKSLLYDRSGDQHYDTISALHKSIRGSDPDAALYYLARMLQSGENPLFIARRLVVATSEDIGLANNVLQTYATSVYLMIEKLGIKDAQSALAQLVITMCLSKKSTRSYRGMNNAFAAVKEPGMGDLPVPFHALDRRPELLNEAARLMSTHSKQTQEGPESTQRFLPRALEGRKFLEDTDFLFKRDPDLSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5W9</accession>
    <name>A0A8G1R5W9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_271604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516227.1">
        <property type="nucleotide sequence ID" value="XM_025655097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5W9"/>
    <dbReference type="GeneID" id="37158499"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="76" mass="8107" checksum="7F81AE043EDA461A" modified="2022-01-19" version="1">MGFFIFLFPCGNVPGSAHPLIGALLIRQSKGMTYPTEVGRVLVNSGMHLPWASGTGHMVPSSVPGYDNSSPYERGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6P3</accession>
    <name>A0A8G1R6P3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_392308</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518426.1">
        <property type="nucleotide sequence ID" value="XM_025656841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6P3"/>
    <dbReference type="GeneID" id="37160243"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034193657" description="CFEM domain-containing protein" evidence="10">
        <location>
            <begin position="22"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="11">
        <location>
            <begin position="629"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="280"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="797"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="305"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH60504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="845" mass="85149" checksum="C98DF32C9E213802" modified="2022-01-19" version="1">MRAVVPLYLISVALWPLAALAHPKGLWWGTDECYPSPGKADNDCSQDQQTGFDWSGLAVGSFSAYAGFEFSGFSLKESFGASSSGKCIVGKLSKERSSGLKMSSGKDQKGFSVSRFRLATSKEADVHIVYNMPDGSSCNDVVSCSPSGTDVTNDQCGGSVSVSFRLEEDIEIETCDLGIYEVEFDCSPSQDTDTSSITVLPSPTKSSSSSTPLILMPPSSPAAASTSAPTPVRMTTSTVYSTKEVTITSCAPTVTNCPANSVTVVTSTIAVSTTVCPVTETSGASPAASTSVSTLAGHHTSNPMVTTSISVPSGSSPVESTSSHSSPVPTSPAVSTAPAASGHGSSAPAVDKTTVVTYVTVTTCPVTSTGSAGGSLTTSVGTTVSTVTLTSTSTICTKCIAPTSVAPISSAPVSAPERTTTVVTYETVTTCPVTNVVTSSGVPITSVTSTVSTMTMTSVSTITPTSAVSSSAHGPTGVAPISSGPVSIPESTTTVVTYETLTTCPVTTVVTSSGKPVTSVTSTISTVTLTSVSTYCPKCTAGPTSVGPVTTAPESTTTIVTWETVTTCPVTSVVTSGGKAITSVTSTVSTITMTATSTIPNTVVPTGKSPATSTGASGVSTPAPSAPCPNVVPKCINTWMNLLPKCSSNSDISCYCPSDDFTKKVISCIQAWGASRAEVQAALSYFTGICAAYVPQNPGIVTVIPTSITLGAGATGAAPVTGTVVHSITDGVAPTTKPATAAPVASTVVTYSTWTVTVPKVVFTTASGSAQTTVGLVPGGPTGVSASSSRLPNPWASSTLATFSGRPTTSQSPSHTPVLSNKASKENNSSGWWWTIAVAALLGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7F6</accession>
    <name>A0A8G1R7F6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF636 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_446060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518831.1">
        <property type="nucleotide sequence ID" value="XM_025659411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7F6"/>
    <dbReference type="GeneID" id="37162813"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF44">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G09754)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH60909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="163" mass="18401" checksum="A9E59436D81F5769" modified="2022-01-19" version="1">MPMKLEGSCQCGSVEFTLESSTPVPYQLCACSICRKVGGYSGSVNLGGIADSLKIKKGKDLIKKYSAVMARGTPDEKICASERNFCSNCSTMLWLWDHHWPELIHPFASAIDTELPVPDEMVCIMESSKPAWVRWPEGKKQVFDGYPEHSLEDWHKKHKLFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7J2</accession>
    <name>A0A8G1R7J2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_369027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517097.1">
        <property type="nucleotide sequence ID" value="XM_025655897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7J2"/>
    <dbReference type="GeneID" id="37159299"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000424">
        <property type="entry name" value="Meiotically up-regulated gene 72 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF25">
        <property type="entry name" value="PROTEIN PAM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="3">
        <location>
            <begin position="198"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="708"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH59175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="748" mass="80768" checksum="3FAEA64A33259467" modified="2022-01-19" version="1">MAPPPRLRILSVGSNAISAFLSWRLQATTSCDVTLVWKSGYEAVSQYGVSFKSKAFGNERFKPRHVVRTPEEAASRENAYDYVILCVKALPDVYDLAAVIESVVTPQHTCILVNTTNTLGVESHLEQRFPTNVVLSLVSGVEITQIGASEFEHLNSSEIWVGATNQNSNVPSSIQTDMAAALAMTLSSGQVDCKVSKNIRQEQFERIIGPIAFYPASVMFDSGNVQQLLEKVGVRQLISDVIDELIDLAKAHGCSFPSDFNQKTTEKMTSIQTQNTMYQDFQARRPMEIETYLGSPIKLATESNVKLPRVETLYAMLHHINATNLSKPRDSPPPALAQPPPRVSSVPPPRNGPMRPPPGRSSSAMMMPPPRRGPPMPGMSRPPSAQPPAGGPRMPREPSLEGLEEFSHLVVYDDAGDQGMPANGANGYPDVPPGPGPSGLALRERELAIRQRELQLREQEMHMRRGPRRPPPSKAASFDEEDEDDYFDPMDTSLVPQIDPDNVDMLSITSKRTKKFPSASQIRKNPELLSSTGPGGGGGGRTGTFSRYFGGNRKRASDRIMQEIPGLHDSLLDNPMMAYSSNRYGSVDRNQMAAGSRTNSMTTSRMGDYPPHPYPQSRRNSHSPAAPFGGPPGPRMGRPATAQDQNFGPPQGPPNGGHPSPPGHMRAPVPRHPPGHGNAVGPQQVEQQIGVSKPYPAKGTPKHRSLTGSASASAESGDSGASANLDSETSAHSSQISLGAQPAAAPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8R7</accession>
    <name>A0A8G1R8R7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_446541</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519305.1">
        <property type="nucleotide sequence ID" value="XM_025659530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8R7"/>
    <dbReference type="GeneID" id="37162932"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000011">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH61383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="145" mass="17048" checksum="FCDE60B7B33B1A04" modified="2022-01-19" version="1">MVLSFILVQNRQGKTRLAKWYAPYSDEEKVKLKGEVHRLVAPRDQKYQSNFVEFKRSTKVVYRRYAGLFFCACVDATDNELAYLEAIHFFVEVLDQFFGNVCELDLVFNFYKVYAILDEVFLAGEIEETSKQVVLTRLEHLDKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8W5</accession>
    <name>A0A8G1R8W5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_445674</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520168.1">
        <property type="nucleotide sequence ID" value="XM_025659324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8W5"/>
    <dbReference type="GeneID" id="37162726"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH62246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="241" mass="26820" checksum="90939EA4DCD9FD90" modified="2022-01-19" version="1">MEPSYQLVAGDEPNANSRKRPFQNPNLTTSTSYKITSALQYFHPFAFFSLLGICLLEASTILFLVRSYSDASQPWPASPVPPIPWISRNFTRTATMTNLTSVAEVEAAWGAYETTAFVHVQRPELYSLPPNKDVLAGTANVYMLSVHHQLHCLKQLHVATLHFPGGNGQQNHAEDSESVRHMEHCVDYLRQAILCAGDATLEGPDPGKRTLSGYGTTHQCRKWDGLNGLETWRLLNSPQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9C4</accession>
    <name>A0A8G1R9C4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_446022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518789.1">
        <property type="nucleotide sequence ID" value="XM_025659401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9C4"/>
    <dbReference type="GeneID" id="37162803"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21456">
        <property type="entry name" value="DLC-like_SpDlc1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF4">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH60867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15088" checksum="92998D1F74A6E1E6" modified="2022-01-19" version="1">MAVDAATPSSPVPIPELTKIATEACDTALKDVTEYEHTKVGDWNSQIINTILKALITATAPSTPSTAPPYRFTVNSTIVQQGLIDKSAAADGATSNTGKRGMHSASGAFWDVNRDGMWTFKYPGAEERGLDVVVSVTWFALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9K2</accession>
    <name>A0A8G1R9K2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_448219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517182.1">
        <property type="nucleotide sequence ID" value="XM_025659883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9K2"/>
    <dbReference type="GeneID" id="37163285"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40628">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40628:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="181" mass="20175" checksum="84A920DF760C66F5" modified="2022-01-19" version="1">MTTRPLSPPTSPRKRTKAMHLPSSQRICHDWMVVQGNVHYARDRAHFTTYRPVTAHLKNNIFNPMDELEVAGIGTVEIPVVRSLDNPFDTHTIVLENVLHIPEAVCNGFNPLLFGSSMSCTETAWMGADCEGRLMWVAMPFRGGSRLVLAGGLVGESEIIEGRYYTLSLYVSPEEKGEFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA73</accession>
    <name>A0A8G1RA73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_391241</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Lipid-anchor</topology>
            <topology evidence="1 11">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519318.1">
        <property type="nucleotide sequence ID" value="XM_025656799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA73"/>
    <dbReference type="GeneID" id="37160201"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF4">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034468063" description="1,3-beta-glucanosyltransferase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="420"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="425"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH61396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="486" mass="52138" checksum="B4575087AC248101" modified="2022-01-19" version="1">MFPTYTQLFAAACAFATTANAVTPIEVKGKDFVNSKTGDRFQILGVDYQPGGSSGFSATEDPLSDADACLRDAALMQNLGINTIRVYNLSPNVDHSKCASIFNGAGIYMILDVNSPLSGGSLDRTNPSSTYNSVYYEQVFGVIEAFKNFPNTLGFFAGNEVINEQSVYEAPAYVRAVVRDMKDYISTNVNRSIPVGYSAADVRPILMDTLDYFECNLENSTSSRSDFFGLNSYSWCGESSYKASGYDVLTEDFSNASLPVFFSEYGCNAVQPRVFTEVQALYGSEMDQVFSGGLVYEWTQEANEYGLVAINSSDTATLLVDYENLQKQYNKLDMSSIESSNSSQTSKEAVTCSSSLITNNTFLNSWDLPTVPSKVADWIKNGYTNATVGSLVAVSATTIPQTIYDYNGNKVSSVKYKVLSDDESNTPGNSTSLTSSSNSSSSTSSSSSSSSSGSSSSDSSTSGSSALSAPFMGVLTGATLFAVFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAE5</accession>
    <name>A0A8G1RAE5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_456742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519061.1">
        <property type="nucleotide sequence ID" value="XM_025661468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAE5"/>
    <dbReference type="GeneID" id="37164870"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="47210" checksum="DE0F592133D94294" modified="2022-01-19" version="1">MKKTLLLVFIHGFKGDDDTFGEFPGRFCGLISRALPAVQVVATVYPKYETRGELKGCVSNFREWLQNKVIDLEVSNRTASPTVDPSVHVILLGHSMGGIVAAETLLLLASEQPIPAPSSADSATDTLVDSESAVGAHSFMFPHIQGVIAFDTPFLGIAPGVISYGAEGHYRHATTAYTAISEVAGLFGLGGNSSNKASTDQGKASNKSLPPSAPSSSSNADAAATPSWQRWGKYAMFAGAAGALAAGGAAAMYSQRDRLTDGWGWVSSHLSFVGSLARPSELRRRLALLAEVQRDRGIGCTNFYTCLGQNASDLVENKNVGTSSFSQKIIRSKNRTFCSLPAEVESSGSSQQDIRWARAVNDKAADEIKAHISMFLPNENPAFNLLVSDACKVLVESVDKGWYATATGPIEEVDGNMPRSDDDRSKDQTDSGFMDGDDVVVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAR4</accession>
    <name>A0A8G1RAR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_494961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521128.1">
        <property type="nucleotide sequence ID" value="XM_025663891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAR4"/>
    <dbReference type="GeneID" id="37167293"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF23">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLPHOSPHATIDYLINOSITOL DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="276" mass="30583" checksum="78BE60247B20E23C" modified="2022-01-19" version="1">MKTYGIWSKLATLGSFTLSSAKTLNFVAHEDDDLLFLSPDLIRDILSGEPIRTVFLTAGDAGMGSDYWNSREDGSRAAYARMAVASNNWDEDVIYVGDKTISLYTLQDDDDISLAFMHLPDGNMDGTGFGGTDQNDSLQKLWDGDIDVIRTIDGSGVQYTRDELLDTIAALIDDFDPDEVKTGDYVNDFGDGDHSDHYATGYFVDNALQQADSDADLTGYYGYPIQNMDVNLDDSDIEDKTNIFYEYAGYDTATCATDDACSSRPESAWLQREYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAX4</accession>
    <name>A0A8G1RAX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_467559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517827.1">
        <property type="nucleotide sequence ID" value="XM_025662196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAX4"/>
    <dbReference type="GeneID" id="37165598"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH59905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="446" mass="47385" checksum="AB90D49FF67D49EF" modified="2022-01-19" version="1">MVSITAVRDNNGAIPRLYGSDLVAVFVGGTSGIGESTARAFIRNTTASRAYLIERDQARASRIIEELRQIKPDSQVEFIKADVSSSGEDRLNLLFLSPGTGSMKGPDEAVQGKTILITGVSPGSLGLATAEAFTSQLPTNLIISGRSTEKVQAAITHLESTYPATTYHALIMDLSSQKSVRAAASQLLANTSIPTIDILINNAGVMSIPTRTLTEDGLETTFATNRIGHFLFTNLILPKLIKAASTTTTTKASDSGLAPPTRIINLSSFGHKFSPVRFTDLSFSILPNELPESERPDLRITEHTTASSPTAQSKTANILHAISLNQKLLAKYNIAAFAVHPGAVDTGIGRHAIPSDVEAALQRVKDLGMDPTQKSREVGANTTVLAAVDPRLKVVGVDSGDGQVKGVYLADCKVDDGGVVAFATDRGIAERLWSVSEELVGERFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAZ8</accession>
    <name>A0A8G1RAZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_118855</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519768.1">
        <property type="nucleotide sequence ID" value="XM_025653895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAZ8"/>
    <dbReference type="GeneID" id="37157297"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000167">
        <property type="entry name" value="Uncharacterized mitochondrial carrier C29A3.11c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="41"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="150"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="261"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH61846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="348" mass="38205" checksum="9DA34AA7233DD7C8" modified="2022-01-19" version="1">MTLDKHSEHAPFSPPPPQPSPLARSTQTTLTMDEATRNKLLKSYKTQVASASSTVFATLAVTPLENVKTRMQTHNFQNVAQCIRYLWRTEGPRGYVAGALPPLASVTAVRVMNFTTYAFAKNKVSDFIQRMTGESPLEIYDQEGSSPTVSTVVTFTAAGLFAGLVSSPVACPFELAKNVVQTSVLMSHRSQASNNAPNDPSLRNMPRLSTTEAFRQIYKRYGFRGLYTGFHLHALRDTVGTGLYFGVYETVKQIAEREMGKGTGAPAIAGAICSTMPWFCTYPLDTRKTRAQSVLLGKSKEVGEAASAMAKSSIYKGLSIILVRTAINNMILLSIYEYMNKRIDNLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB35</accession>
    <name>A0A8G1RB35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Extracellular dihydrogeodin oxidase/laccase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_364182</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519406.1">
        <property type="nucleotide sequence ID" value="XM_025655689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB35"/>
    <dbReference type="GeneID" id="37159091"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000082">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF502">
        <property type="entry name" value="MULTICOPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="42"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="164"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="383"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH61484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="558" mass="62374" checksum="0C499EC9F1DA9BED" modified="2022-01-19" version="1">MQGNSSQSLNTPWQGYDLDTNYYETVPQTNVVRDYYFDIVNTTAALDGVERPVLLVNGQFPGPTIEANWGDTVKVHVTNRMENNGTAIHFHGIRQLYNNQMDGVAALTQCPVPPNSSYTYVWRAEQYGSSWYHSHFSLQAWEGVFGGIVIHGPATAEYDHDLGVVFLNDWSHQTVDEMYQSVLESQGPPHFQTGLINGSNIWVTEDNQTIGRRFHTEFAPGQSYRIRLVNAAMHTHFKFSIDNHDLTVIASDFVPIVPFTTNNVPIGMGQRYDIIVTANQAPDNYWIRAIPQSFCSDNSNPDNIKGILHYKGASGDNEPTSTKWDYGDDFQCLDFSLDELVPWLALDADIGGAQMHESDVGFSPFGDVPLYLWTMGGNALNISWKDPTLQQTFEDPDKMDWEASQGVIEAAIANKWTVLVVQTDLPVPHPIHLHGHDFYLLAQGFGQFSPQNVTLKTKNPPRRDTALMIADSSPTGGGGYMVIGFPADNPGVWLIHCHIGFHATEGFAQQVVERQSEFNSFFSEDLLVNTCDAWDEYAKVNPYGRQYRGLAGPYESGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB72</accession>
    <name>A0A8G1RB72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoflavone reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_444300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520890.1">
        <property type="nucleotide sequence ID" value="XM_025658983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB72"/>
    <dbReference type="GeneID" id="37162385"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH62968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="359" mass="40455" checksum="F0B62F8B17F0F76A" modified="2022-01-19" version="1">MSRTRVLLVGAAGETGGSIANGLLENPGFEVHALVRPRSVQKPAIVALQERGVQIRKGDLKGPEESLADVLTGIDVVVSCVGPAEQQDQIPLAKAAKSAGVQRFIPCGFITVAPPGGIMWLRDEKETVYNHIKQLRLPYTIIDIGWWYQLSYPRLGSGRTDYAMTTANNEIVGDGNTPLALTDLRDIGRYVAKIIVDDRTLNKMVFAYNTVLTQNQIYDLLEEISEEKIQRNYIPEETIYTRVLAARQSSETYPFDPVKFIPRYLAENQLSWGVRGDNNPEYAKYLGYLTSKDLYPDFAPHDFREYLEEVVRGTAKGVYTDRVISKAHQRMFPRTESSDSLYTRIFPRTESSDSLYMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBC1</accession>
    <name>A0A8G1RBC1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_110487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519526.1">
        <property type="nucleotide sequence ID" value="XM_025653848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBC1"/>
    <dbReference type="GeneID" id="37157250"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="114" mass="13080" checksum="D315F3931F2F40B0" modified="2022-01-19" version="1">MESEHTSTITIRLRIMDKARIAWAWRESERDTPPPPTEERILLLRVIHPVARCNPRPKRLSTHSRSAAAGVTERPGHPPSNCGEQQLGLGTFFILPVHPFDRSRPQQPRKFKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBM5</accession>
    <name>A0A8G1RBM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_485172</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519362.1">
        <property type="nucleotide sequence ID" value="XM_025663307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBM5"/>
    <dbReference type="GeneID" id="37166709"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="269"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH61440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="681" mass="75491" checksum="DD29643221DEF798" modified="2022-01-19" version="1">MNDDTADSRSMPLRAHTEDGPTAFPQNALMSNDGHNASNLRTRQASGFRSSRGSRSRITAMGITPDGLFGFSESEDEFFGDSSVASFLNQIKESATKEPEKGRSTTNPVPSATFGTPSIPMPPVADNSLSVKAYDLPPRQLADYLLNFYFDKIHSLYPYVHKPNFLRAYRRLWTPDTETDTETISSGLGLGDAYVPPALFHCALNIIFALGCHFSKLDHTARQATAEEFFQRSQRLLNVMSLDKGDLALVQTLLLTSQYLQGGESPSRCWNIIGLACRIAQSLGMHSLKADRPRTPAQIQMRRRVWHGCVMLDLASSMMLGRPPMTHSSAVPLPEAIDDELLDSSTAACQSPAGTLSKAEFYVRTLQLYKILRKILYDVYEPWEDGGSPDQSERPKSENEIAQTLLSLEEELLEFESSLPAALQWRDAQQPVGVAGPFRRESSLLRGRFLHLRILLLRPTFVKFCRDNLPPRQAGGYPRHQQVPLKSRIAVDFSISCSASCVETAIELSHLMNEISTTELASVWWYNVFYAFTAGVVLILAQASPAMKSRFSQPVLGNAWKSCCDCLENMDLYSNTARNCATNLRKTLSQVLGGQGHETSVHIEKPAPQTTDRHLGHDVNLSKAPNIFSLDGSEVGDGSSQGALDTQFSEALDSLWSEDDVNSSLMQMLWDDLWLAAPSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC59</accession>
    <name>A0A8G1RC59_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_444780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521415.1">
        <property type="nucleotide sequence ID" value="XM_025659107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC59"/>
    <dbReference type="GeneID" id="37162509"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="4"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="409" mass="45760" checksum="BBB15E0FF35474C4" modified="2022-01-19" version="1">MLPKRLIVCCDGTWKDSTADSQEPPSNVTRLTRTLSRVAVVEENGVNKEIPQIVYYQKGVGTGLADKYFGGVAGIGISANVRAAYGFLVDNYEEGDKIYFFGFSRGAYTARAIAGIVCELGLLTPRGMDNFATVYDDFYDRKLPVYDEEKRRQLGFRDPLPRFTVEIVGVWDTVAFHKPWMFGNWSGEKLEFRNTLLSREVKYAFHALALDEERSAYQPTLWHQPENADGQELLQVWFSGVHTDVGGGGQDPRLANITLAWMIAQCTKHNQLSFDIEEYLFDRPPRPLETDTAPWATAFGKTNTGSFARTVETILGGKSKRTPLQYKQTGDGNPQPTNEVIHASIEDRVLSGKGTIAGAVLWPSLVIERLTPDQEWVLDSGGKLVQAPVLKEELFMKGRIRTVHVDEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCH9</accession>
    <name>A0A8G1RCH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_444002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520578.1">
        <property type="nucleotide sequence ID" value="XM_025658920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCH9"/>
    <dbReference type="GeneID" id="37162322"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="233" mass="25664" checksum="5057F4148A577720" modified="2022-01-19" version="1">MESVHKILASARAAPYGNLLPAGDNLFLSVAEAVQDHMSNYDASHDFNHILRVLALSQHILLAEFNTTKTYDPTVVLLSALLHDVNDKKYAPPVIEGQQQTSKVTLVLQQAGASAALAARVEEVVNHVSYSTETKDPNKVLSVIQQHPELAIVQDADRIDAIGAIGIGRTFTFTGAKLAGASMQNSREHIDDKLEKLEGMMKTATGRQMARDRTERLTIFKKWWDEETMMVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD79</accession>
    <name>A0A8G1RD79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_517345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519057.1">
        <property type="nucleotide sequence ID" value="XM_025664897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD79"/>
    <dbReference type="GeneID" id="37168299"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="259" mass="28466" checksum="BE52902E589F25E6" modified="2022-01-19" version="1">MSKSTSHVLHHIHKYISRSDSSTTSDLTVQAKVGLAFGILGAILLTIILTTLIVLRIQHDPVITLRTLFSRTPIPIGQRQSLSIEISPSDEESQPPPAYTHPHPLPEAGSKGNADIPLPPQQAHIPPSLRKELNLHVDTSTTTTAIATKPKPTPLRTMSDTEIVKSSTSTSCEKDREARSSTLKVQIHHHLHHNHNHPYYSRLRVGSPRSPVGNGAAAGMKSDRLCPPPDEYAVPPDSPDVIVLPSPRELQKFRINVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDH5</accession>
    <name>A0A8G1RDH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">YT521-B-like splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_484431</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520352.1">
        <property type="nucleotide sequence ID" value="XM_025663238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDH5"/>
    <dbReference type="GeneID" id="37166640"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057720">
        <property type="entry name" value="RRM_YTH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25701">
        <property type="entry name" value="RRM_YTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="297"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="YTH" evidence="4">
        <location>
            <begin position="418"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH62430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="68877" checksum="CFEE1958F677B8D4" modified="2022-01-19" version="1">MTYPNGDAPSALSNSTQGGPNGAKPQAFNKSHEVEEPPPQSVSTITTSREAPRSDNDQQHPKSQAQMAQAARGGAPPFSMRDMRSALPGYQSHSILYEQHHIQQPFVPTAHPHGLVYAMQPLPSFTGPSMNPNMAFNGPFNQVYTPYLQQQPEDPLLPPGAAGYQSLGPHSAAHMNVHIPGQSGYGPNYYTQTTYTAALGHGPGPPTTSSPVQVQPRVQPRNTLGPKTKLTPGLGKENKQRRLDLEYDVSKTIVDGSTPMRPHPVQTFPADSGSHSSNTTTSSAPRGPPRKPKQSGHALWVGNLPPGTNIVDLKDYFSQNATKELESVFLISKSNCAFINYKTEAACAAALSRFNDSRFHGARLVCRLRQGAVSLSSNPESMGSSTPAIYQDEETKPSDAVTEKKATEASLSHTRVPSRYFIVKSLSVDDLEISRQNSIWATQTHNEKQLNEAYENADDVYLIFSANKSGEYYGYARMMSPIQDDENLAMEMPSRLDNPPDPEALDVTPTPATSTAPNGRIINDSARGTIFWEAETSEDESGASREKEKEKVIHEKSEEATDMGAQLIGKPFRIRWLSTTRVPFHRTRGLRNPWNSNREVKIARDGTEIEPEVGWKLLQLFHSQPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RF31</accession>
    <name>A0A8G1RF31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_495440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521446.1">
        <property type="nucleotide sequence ID" value="XM_025663924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RF31"/>
    <dbReference type="GeneID" id="37167326"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="370" mass="40805" checksum="A841399EB1A1D4FC" modified="2022-01-19" version="1">MAELTSPIRIGGLELHHRVVMAPLTRNRADAQHVPLPISRDYYAQRASVPGTLIITEGTFISARAGGMGHVPGIWSDDQIAQWKIITSAVHSQRSFIFCQLWALGRAAKPDVLQKEGGYRVVSSGDIPMSESSPTPTPLTEEEISEYITDYVRAAQNAIAAGFDGVEIHGANGYLPDQFTQSVSNNRTDRWGGSIENRSRFGLAIAKAVADAIGPHRTGYRISPWSTFQSMRMSDPRPQFTHLVRGLAQLNLAYLHVVRPRISGSTTVEHETEEEDESFLYEAFGDRGAIILAGGFTAQTATEALRAHPGYRVAIAFGRHFLANPDLPFRLREGLPLNQYDRPTFYTPMSPKGYVDYPFSEGFSPSQGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RGY9</accession>
    <name>A0A8G1RGY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-ketoglutarate-dependent taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_18903</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521052.1">
        <property type="nucleotide sequence ID" value="XM_025654417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RGY9"/>
    <dbReference type="GeneID" id="37157819"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF30">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_7G06030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="88"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH63130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="376" mass="42973" checksum="ECB3317927BA9F8C" modified="2022-01-19" version="1">MPSSAPVLRPKKALPINAHKEEEPISYDINIPYVDVTKESHLRTRYPEYLPTWDKVWFDPLPPFEYQDPALRVKDKSKRNLLTPGTKVTEIQPRIGSIVEGVQLNQLSDAQKDELALLVAERKVVAFPDQDLIDDGPEAQEAFMRHFGKPNYQPVSGSMRGHPGFHIIHRDGNREEITRFLSQRTTTTLWHQDVSYEIQPPGYVMLGLLEGPEVGGDTVFSATDMAYKRLSPTLTSWLDTLRATHSSAKMIQHARLTGSLVRKEAVDTVHPLVRVHPVTGEKCLFVNGEFITKIQGLKEPEQRWLLDFLMQHIITGHDFQARVRWQPRTIVIFDNRCTTHSAIVDYLDDDNGAKLRHIFRLCALGEKPIPVYDQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHJ3</accession>
    <name>A0A8G1VHJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DRAP deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_429686</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511343.1">
        <property type="nucleotide sequence ID" value="XM_025658258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHJ3"/>
    <dbReference type="GeneID" id="37161660"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="4">
        <location>
            <begin position="133"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="518" mass="57566" checksum="A32AF75EA240F5AB" modified="2022-01-19" version="1">MSLVPVDTTLQVPPPDPVQEPPEVAITPCDPWPAPYYLEGGLRRVKPYHYTYNTFCKERWRGRELVDIFLSEFRDRPAEYYRKALQDGLVAVNGTPAGPNTVVKNGQIISHTLHRHEPPVTGKEIGIIHEDDDLIVIDKPAGVPVHSAGRYHYNSVLEIMRSQRHPEWVPRPCNRLDRLTSGVMFLGKTPKAAENMTGKLKARTLQKEYVARVKGKFPDGVIVCDQPIMSVSPKVGLNRVRATGKEAKTKFRRLAYVPPQAPEPQSAPDAEGRVATPPPVYTNEDEGYSIVHCLPLTGRTHQIRVHLQFLGHPISNDPIYSNRKVFGPDLGKNETSDERDNELIDKLCNIGKTEVPDTVSYRTHLTTVPMVPPGTDNSVVEEIMSREHEAAVERYHKRKGEMLSGERCKICDTELYSDPRPEDLGIFLHAAAYSDKEEGWKYTSKMPSWALPPDGVEGPREMPDWVFGPEEEEIVIGHAVLPGAEDGSETNIPALVQGVGLVDISSGRKADAAAQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIP7</accession>
    <name>A0A8G1VIP7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mating alpha-pheromone PpgA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_385057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825090">
        <property type="protein sequence ID" value="RAH51938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509860.1">
        <property type="nucleotide sequence ID" value="XM_025656574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIP7"/>
    <dbReference type="GeneID" id="37159976"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034651358" description="Mating alpha-pheromone PpgA" evidence="1">
        <location>
            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH51938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11467" checksum="8B6383C50FD51559" modified="2022-01-19" version="1">MKLVSIVLAALAATTVQAAALQRWCHLPGQPCNMIKRAADASGEVKRSADALAEAIADASPETLQRWCVLPGQPCNKIKRAVEAGSEVKRSADAFAEAMADIDESDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIW1</accession>
    <name>A0A8G1VIW1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_461954</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512693.1">
        <property type="nucleotide sequence ID" value="XM_025661818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIW1"/>
    <dbReference type="GeneID" id="37165220"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052174">
        <property type="entry name" value="Flavoredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43567:SF1">
        <property type="entry name" value="FLAVOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43567">
        <property type="entry name" value="FLAVOREDOXIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="5">
        <location>
            <begin position="62"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH54771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="277" mass="30854" checksum="86F164F69FBBDC7A" modified="2022-01-19" version="1">MNTKRDVNVSLQQPLNESESEPDRAPKKSRLEFSSNDGDDKRNGLDQFVAYPIHKVNRLLEPGPILLVATGSIANKTHNIMTMGFHMMIQHEGPTLVGACIGPWDKSYDNLKKTGECVLAIPAVEMLEKAVDIGNCSGEDVNKWVNFGITPVPASDPASADGLWDRKGGEEGRARAPLVGGKDVIANIQCMVEDRALVARYNLWVLKVTGAWINRDMDLEYGQGSRDPADDDDRVGGGKRRKREMKMAHHRGDGRFVIDGKEVDLRDRMVKWKEFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJI3</accession>
    <name>A0A8G1VJI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_78925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513576.1">
        <property type="nucleotide sequence ID" value="XM_025665664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJI3"/>
    <dbReference type="GeneID" id="37169066"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="70" mass="8285" checksum="847D9D1E81D45A8D" modified="2022-01-19" version="1">MRKVRVVLRIYLSIRYVLNVQKEGAASTPIIHRFVVLMLALMHSLCFSRSIFAYTKMTDNRNQKKKKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK33</accession>
    <name>A0A8G1VK33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_479049</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the SHE9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514028.1">
        <property type="nucleotide sequence ID" value="XM_025662929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK33"/>
    <dbReference type="GeneID" id="37166331"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="94"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="356"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="181"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="356"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH56106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="497" mass="55451" checksum="B68C2A5A765C10A8" modified="2022-01-19" version="1">MQSMPLLLRQSFKSTLNLTRTTRPVRRPLLPAVGPNSLYPAPRNFSICLQCQFRSQSSLYSSDPLKDGKPAEQPKEDESPVIALPAGNANLQADAGTQQQTPPAAAEAGESTQSQQQQQRQQEGEKSEANGKGWRDGGLPSYIEQRRSQFTKRFSDVMDNLQSNIFVAGQRLNDLTGYSAIETLKKEIHTQEERLRNARLQVRAAKDAYAAAINNRSTSQREVNELLQRKHAWSPTDLERFTHLYRNDHTNEVAEHEAQEALSQAEHEAEEAAAQLSKSILSRYHEEQVWSDKIRQMSTWGTWGLMGVNVLLFLIFQIAVEPWRRKRLVKGFEEKVIEAIEKEKALDRIQIVSAQSQMAQESSTTSTASPATPETAETTTTTEQSASTTADEPISDTDAIVTIESTEPEVFSSDPADAEPSANTTVSKPTPDNIKEYIQYQLSRVSPLIESLRQYLHDLFSDRQVVLTQRDLSTVALQSAAAGAAVIGLLSMIIRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK76</accession>
    <name>A0A8G1VK76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_450462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514371.1">
        <property type="nucleotide sequence ID" value="XM_025660380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK76"/>
    <dbReference type="GeneID" id="37163782"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH56449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="267" mass="29890" checksum="72326123AFB2C59E" modified="2022-01-19" version="1">MALQGVEQTILRDPALFYWIVFPITVVMILTGILRHYATVLMNNPPKPASTLAESRERLGLIRGVNLRNNSSVLSKESFEMRKNYLVSAYQSGAFLKDPASRGQPPANPMTDPAGMEAMMGMMKGNMMMMIPQTLIMSWINAFFSGFVILKLPFPLTIRFKSMLQSGVMTRDLDVRWVSSLSWYFLNLFGLQSVFGFILGSDNAANHMASQMASMNPAAGINPFQPGQDPDKLYQSEAENLEVIEHFCILDGVEERVLAHYAGRKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKH7</accession>
    <name>A0A8G1VKH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_442045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511645.1">
        <property type="nucleotide sequence ID" value="XM_025658824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKH7"/>
    <dbReference type="GeneID" id="37162226"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="267" mass="30116" checksum="08BB7C8E35A6B691" modified="2022-01-19" version="1">MPNQQPLSPLIPRSIPQTTRPNIVPHHYHHHSSSRQTGGNNSSPRAMQNRLPPLMLPGASPRLSTLEPFTTTTSPSPSFPSPSTSTTSDPLVDIVRSTPNQHPLTEEQTLKLWHKILVKIYPQNGEFTHDLRTAEINGARIVYCLVKQNTWPSPGTEPVSSPMAIILCKEAEEYHREDTWDRTSNQLGQLSKCPGQPWCAVAYGRQLVCMYRCTQRLEGFEMFRMGSWMFDVGAWNGRALLKQLLDDVKFGKWKAMNKGRGPSFRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKW0</accession>
    <name>A0A8G1VKW0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_471323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512020.1">
        <property type="nucleotide sequence ID" value="XM_025662469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKW0"/>
    <dbReference type="GeneID" id="37165871"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="32136" checksum="1DF89BE940233AE2" modified="2022-01-19" version="1">MREAQIQLRLEDVWIGVTDPKKRRRLQNRLNQRARRRRQHLTKALPERSGPYYPHAWSTTASTPCQLDFRCLDELRIFGPLAADSRSILQQLEAMVHVEFATGSLQADMRLGVTRLNILRALYTNIDILGYDARYMAADEALSMFAMIGPRCLATIGREALLPPALQPTEIQRTVPHHPWLDLIPISRMRDNLILMENLMDDGQMCRDMCGYHSQVLRAGRRCQTGIGETGVIEITETFFQLWGWSVKDCWDLFRSTNAWRMRRGERPLFAMPCASNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL00</accession>
    <name>A0A8G1VL00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sde2 N-terminal ubiquitin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_470186</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513789.1">
        <property type="nucleotide sequence ID" value="XM_025662382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL00"/>
    <dbReference type="GeneID" id="37165784"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050896">
        <property type="entry name" value="Mito_lipid_metab_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024974">
        <property type="entry name" value="Sde2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434:SF1">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13019">
        <property type="entry name" value="Sde2_N_Ubi_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sde2 ubiquitin" evidence="3">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="SDE2-like" evidence="4">
        <location>
            <begin position="96"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="937"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH55867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="958" mass="106033" checksum="EDDB8BD39DAD3B44" modified="2022-01-19" version="1">MASQNVNVLLSTFPGLSLPSTLSFALPSSSSVADLTDKIASYLPPSLPLNRLVLTTTSNKQLLPSSESIASYLISTNDNLATTSILPLRLSTPLCGGKGGFGSQLRAAGGRMSSKRKRNQGDDNGSSRNLDGRRLRTVNEAKALAEYLALKPEMDKKEKEERRRRWQAVVEAAEKRQEELKNGGGKQKIDGQWMEDKDEMNEKAREAVLMAMKDGMWTDNLRDTILGGSSTSASPSEGSGRETPSSSEEESDDEQEMEDAPGPSSAEPVRNAAPRRYIGFDEDDEFMTLQHPQTSPTMSPYLGRIIPRGRLPYHRAPLQISRLRKPCLRTTTAIFSSRPEILARTEIPVQLRSFSTSIPLRASPAPEPTIEEAVLPVCCPGCGAYAQTVEPSEPGYYGKTRKQTRKLLSETKQVVEGEGNGEEGSGLKAEGEKAADRIQKYLELTDVGGSVPRPKFGASLVKAADTAGKYLEKSKAPVQICDRCHDLLHHNKAVPAISPTMESLRAYLDESPHKNNRIYHVVDAADFPMSVVKEIYDTLGIMDPRSKNRRSATYKYKSGKKLPTISFVINRSDLLAATKEQVDSKMEYVRSVLRDTFGLSHEEFRLGNVHMISAQRGWWTKKVKEEIREHGGGIWVIGKANVGKSSFIEACFPKDSRNLEKIADLIELREEESKIATHYDTSAIDSEGLLPPAPREDLYPILPVVSSLPGTTVSPIRIPFGRGRGEMIDLPGLERGELADHVRDEFKRDLIMTKRKKPERLSIKPGQSLLLGGGLVRITPMNPEDVVMAACFVPLESHLTRTEKAIEMQTEQRPYPKTNIAREGTGQVISSAGVFDLKWDVTHSHLPRSIAKAVEDGHMKMPSLPYKVMSTDVLIEGCGWVELTVQVRAKSAKESDSEDETSRSFPQVEVFTPYGRHVGSRPPIECWKFIEAKKVADNRAKGPRGRQNIGLEKRARHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL04</accession>
    <name>A0A8G1VL04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_462414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in protection from oxidative damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512140.1">
        <property type="nucleotide sequence ID" value="XM_025661848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL04"/>
    <dbReference type="GeneID" id="37165250"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="7">
        <location>
            <begin position="106"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH54218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="370" mass="39333" checksum="B1EEDC199AB863B8" modified="2022-01-19" version="1">MSSSSSSRSGSRPPPTTSSTNATTPSSLQQSAASYFSYPVTHVVSGLYRRLTDPPTNNNNNMRRKTTTTTTTTNNDPSNPVFTPIRTASPFQPPPLTPLTLSDPSPLLTRSLAEEIRLLVPPRLQLCNTWHLAYSLDRDGASLSTLYDNCRDIASTRSPRAGYVLVIRDASPSSNAVFGAYMTDPPHPDSHYYGTGECFLWRASVLPPATAMLSNFTNGDTAGEEGGAGAGVEAEVLEKAGLPLPPSADTTNAGRSTTLRRAEGEKWLSPTSTSGVGNGGGASSGRTSGTVTPEQIRFKAFPYSGVNDYMMFCETGFLSLGGGDGHYGLWVDSSLEKGVSASCQTFGNEPLSDEGVKFDIIDVEVWYVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL41</accession>
    <name>A0A8G1VL41_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PB1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_460318</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCF2/NOXA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514267.1">
        <property type="nucleotide sequence ID" value="XM_025661713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL41"/>
    <dbReference type="GeneID" id="37165115"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06408">
        <property type="entry name" value="PB1_NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000017">
        <property type="entry name" value="NADPH oxidase regulator NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034892">
        <property type="entry name" value="PB1_NoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN C23A1.17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="9">
        <location>
            <begin position="435"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="243"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="397"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH56345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="524" mass="58911" checksum="3AB06BC990C0DCAD" modified="2022-01-19" version="1">MSLKQEIETWVQALDHYDNQEYDEALRVFGAIAETSKILFNCGVIYATLGEHERAVECYQRAVGLDQYLAIAYFQEGVSNFLLGDFEEALANFNDTLLYLRGNTSIDYEQLGLKFRLFSCEVLFNRGLCYIYLQQMGPGMQDLQYASKEKVTPDHDVIDDAIREQAAGYTVFSIPVGVVYRPNEAKVKNLKAKDYLGKSRLIAASERSSMPSAASDDLKRTMSMLDHRKPETLPFATSHLVHKNLQSRSRQQSEPPLNRNLFPPTPPPDADKASTNSSTGSLAMNSRPGSIRAARPPRLDLTAGHSTETLVEKPRIGTTRTASESRAGPGRPGPGPGSGPRGPGESHGHRRGMSDTGFAPTVSSEESYSGTRSMPAGATWRRQQERYIDEQEEYASDAYEDNGPDGEFEIMGTRPQASPNRGSRRGTSRRPEVRKFRVKAHSREDTRYIMMEPTIEFREFESRIRDKFGFRTLLRIRMQDDGDMITMVDQEDLDLLMAGSREVARREGSEMGKMEIWVEERGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLE9</accession>
    <name>A0A8G1VLE9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BO85DRAFT_398851</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Associates with the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514582.1">
        <property type="nucleotide sequence ID" value="XM_025657071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLE9"/>
    <dbReference type="GeneID" id="37160473"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="107"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="291"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RAH56660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="482" mass="53007" checksum="C45A510FF18B78D1" modified="2022-01-19" version="1">MASEEPAAGSLADRITKPEETAPAEAPEQTEDIPQTDGAAAQQGGSDLHEPDYTVEVKLSDLQADPNNPLFSVKNFEDLGLDPRILQGLSAMNFRKPSKIQERALPLLLGNPAKNLVGQSQSGTGKTAAFVLNILSRLDLSSEQLQKTPQALILAPTRELARQIVGVIQVMGQFLDGLVIGTAVPADTGARPAKMECSVVVGTPGTVMDMIKRRIMVANKLRVLVLDEADNMLDQQGLGDQCIRVKALLPRDIQVVLFSATFPAHVHEYASKFAPQANEITLQHEELTVEGIKQLYLDCSNDEDKYQTLVNLYGLLTVGSSIIFVKTRASAQEIEKRMVAEGHTVASLTGGIEGSQRDAVIDQFRAGHAKVLITTNVLARGIDVSTVSMVINYDIPELHQPGARQRQADFQTYLHRIGRTGRFGRVGVSISFVSNREEWEMLNQIQRYFNTNIQRIDTKDWDEVEDIIKKTIKSSRAQLGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM69</accession>
    <name>A0A8G1VM69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_276418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516471.1">
        <property type="nucleotide sequence ID" value="XM_025655149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VM69"/>
    <dbReference type="GeneID" id="37158551"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="121" mass="12534" checksum="5CEEA7D74895F719" modified="2022-01-19" version="1">MDDGGGKFDHGVCLVLVCTRSRLSPPPFKALTGRWSRDKTEAPSTGRGGNADSYFAGGAGGGKITPLGCPCTADGCIVSAAWESVSVALTIVMLSINGQEASSRGHYSAWEHSPCCIMVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMG7</accession>
    <name>A0A8G1VMG7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_468293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516593.1">
        <property type="nucleotide sequence ID" value="XM_025662251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMG7"/>
    <dbReference type="GeneID" id="37165653"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF58">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH58671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="504" mass="54498" checksum="12256F06DAAA89ED" modified="2022-01-19" version="1">MSRPVPAVFRPIWRRNFSVSTAKRAIDKLCPSAQEAIKDMKGSSTLLVGGFGFAGVPTTLIDAVRDRPDIKDLTVVSNNAGMPGVGLGQLLESKQISKMIASFIGENKVFEKMYLTGDLSLELTPQGTIAEKCAAGAAGVPAFYTPAAYGTIVQSGELPVRYNKDGSVAIKNAPKEEREFNGKKYILEESIFGDYALVKVHKADKLGNCQFRKSMNNFNEAMAKNAKYTIVEADHIVEVGEIDPESIHLQGIYVNKVIQSTGEKKIEKLTFAKDPNEMLQAGSGEATIRRERIVKRAAKEFKDGMYVNLGIGMPLIAPAYVEEGVEVVLQAENGILGLGGYPKPGEEDPDLINPGKETVTLGRGASVFGSHESFGMIRSGRIDLTMLGALQVSQYGDLANFMLPGKVKGMGGAMDLVSNPEKTKVVVTMEHTDKKGNPKILPECSFPLTGPRCVWKIITDLAVFEVSPTEGLTLAEYAEGVTVEEIRSKTAAPFKVSADLKPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMQ4</accession>
    <name>A0A8G1VMQ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_371135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515917.1">
        <property type="nucleotide sequence ID" value="XM_025655987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMQ4"/>
    <dbReference type="GeneID" id="37159389"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="640" mass="71554" checksum="891C5BD01102F746" modified="2022-01-19" version="1">MSLYSHLCVLSRRRALRSFHISPSLGRHVSIDVNSRASYTEPTPSHLVRFALTGTTKPSHNDVSNPELDKHLSDIFLGDWPLVSLPPPFWSSSGREPQSPDEIASFKALKHDVRNLRHLQVFIERTVNETEGSLILQTQSCALLAKALNRCQRKNSYGEILTALNAIITRLEKLRLPRTSNLYFLGMYYAALSLSAPALERFLDGYLSVGLWPLDSLASASIVNALLNALHYKRFREVTIDTDAILELIEGGKQRRKKNLHDLLSWGDSAGPAMHRGHYLCLLAKLRSRDLLSEVWRQAMWRLSPSASPEMYQCMYSCIVTLMESGDVLRAMDYLQEVSKHSQDMLPGISEFKDVNMLLDSEVIGPLLPRMAGETEYLKLLEAQLIQFEHKLGLSWDSEGPYHTNISDPHSIISDIPLFNIDGDSTGYESVARLITEINAFGCSRSATDLGKIAELLEEHDGDVIPVSLPSTEGQDLEYAWFPRYSPVQCSGASPSARKEGTEPWTPSTLGLVRVSCDSSGSPLERSIHVMQLGRLARRTRCPHDQDPSHDNPWEETEHMIAWDRVYGQLIAVYVGPSNRPIEGRMESRAARARSGIEAITTVSLRGDTAPTSQGDLISFIGNASMHYYIEEDPSPDLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMR8</accession>
    <name>A0A8G1VMR8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_424903</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513895.1">
        <property type="nucleotide sequence ID" value="XM_025658060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMR8"/>
    <dbReference type="GeneID" id="37161462"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH55973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="567" mass="61515" checksum="98D916A4BBF056B7" modified="2022-01-19" version="1">MESAKHSEATLQAQSVAIDDKSLREDVHTPPAEAPVPKSDEKPDEQKWLTGLPLLMVMTAVTLVVFLMLLDVSIVSTAIPHITNQFHSLDDVAWYGSAYTIASASLQPLTGKFYGNFVQKWTFLGFFSLFELGSLICGVATSSKMLIVGRAVAGMGSSGMVNGALNILASILPMHKRPMFMGFMMGFSQLGLVCGPLIGGAFTSYSTWRWCFYINLPIGALVGILLIFTNIPEPHAKPRAAEVFRSVILKKFDLFGFVLFAPAAIELLLALQWGGSRYPWKSSTIIGLFCGSAATFVVFGLWERRMGNDAMIPGQLVKQRIVWSSCMTMSMMFGMTMVMAYYLPIYFQSVRGESALMSGVDLLPNILCQLVMAVLSGILTGRLGYYLPWAIFGSIMTSIGTGLLSMLSPTTSTRDWAGFQAIVGLGRGAATQVPMVAIQNAVTPAQISPAMAILTFSQTFGGSIFLAVAEVLLTAGLRKKIPEYAPSVNPETVISAGATGFRDVVPAKDLLSVLVAYSKAIDEVFYLCAALCVVQFFFVWGMGWKNVKQGKQEQEKKNLDGEAKEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMT5</accession>
    <name>A0A8G1VMT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hexose carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_511566</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516968.1">
        <property type="nucleotide sequence ID" value="XM_025664608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMT5"/>
    <dbReference type="GeneID" id="37168010"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:carbohydrate:proton symporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS sugar transporter, putative"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH59046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="523" mass="57725" checksum="A213DC2C3804DAC7" modified="2022-01-19" version="1">MAQQLLHLTGSALRMAQVILIVAPAFIIFGYNQAGAGPLATLQSWVKVFPQIDTINTTGALEAKNSTGKGAVIASFQIGALIGALSCTVISDRLGRRKTIFIGSIFTIIGQLLQVSAYSLIQFTVGRVILGIGTGQFSVAVPVWQSECSSAKHRGQHVIADGIFMCLGYALCNWIDFAFSRLPNENTGQWRGPLSLSFLPSLVILVAVFLLPESPRWLVRVNRTEEATASLAAYKGMSPEDEAIKSEISGIGLSFENTSQSTRAIREMFSKDDDERLFYRFCLCIILQFFQQMCGGNLISVYASTIFEDNLGLSSSLSKILAASALTWKFVCCFISFFAIDRLGRRAVFMISGTGMAFCMAAMAITTSFGVENRQASIASVVFIFMFNLFYPIGFLGGNFLYCTEVAPQRLRVAMSAISTANHWLWNFVVVMITPVALDTIGYQYYIMYAILSACIPVLVYFFYPETMNRNLELINHVFRDASSPWQIVSMARNLPQGEITPAELVAYNKEKDDCSVEMREHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMU2</accession>
    <name>A0A8G1VMU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_375313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513970.1">
        <property type="nucleotide sequence ID" value="XM_025656165.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="37159567"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="44"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH56048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="700" mass="78640" checksum="9CEB5CBF84573DCA" modified="2022-01-19" version="1">MARRFMIPWLYDLGVWIFTLCLDIFFREVYSRGAWRIPKRGPVIIVAAPHANQFVDSILLMRILKHYAGRRTSFLIAEKSMREPYIGTMAGCMGALPVVRSMDHVKPAKGEIYLPDPDNDPTLVRGRGTDFTSDQFMVGGAIILPRVGKTSPEQQAIEEILGPEEIRLRKPFKKFEKDHPLYEPLRKGTPFKAAPHIDQSKMFASVYSELVAGGCIGIFPEGGSHDRPSLLPLKAGVAIIALGTLAQDPNCGLSIIPCGMNYFHPNKFRSRAVVEFGNPVQVHPDQIEAFKAGGNSKRNAVGSLLETITEALTAVTQQAPDHETLMVIQATRRLYKPLRMKLPLPVVIELNRRLLKGYTQFKDEPKVLQLKKAISDYNRRLRALGIRDHQVEWGDVTHRPWWLVFGTLLYRVGELLTLAIGTLPSVALFWPVFVTAKVVSVKKQRKALAGSVVKLEGRDVVGTWKILVAMGLAPALYTWYTVIVTIWLHYCRHDGYYASVAPWWLNARTYISDSIPLALFSIFFFGLMISVSFAGLRIGEIGIDVLKSLPPLLRALDPRSANSLAKLRAERQALSARVVDVIDTFAPEIFPDFESEKLISHEHPEDDTYQSRLKSMPPSEPETRFSRSKPPEGVLVLKPSSRLKIFSPRSQVSRTSPRSLRPCIYAIYMTICYACNWFGENSGPGLSGSLAMRFNEQKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN27</accession>
    <name>A0A8G1VN27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_512110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517253.1">
        <property type="nucleotide sequence ID" value="XM_025664639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN27"/>
    <dbReference type="GeneID" id="37168041"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH59331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="710" mass="79872" checksum="6DF554A1DEBDA782" modified="2022-01-19" version="1">MTSGAAVTTTTEAPALSGKPTETPVRSRSLGGCETCRRRHAKCDETRPSCLVCERAGLVCERYEIRLLFDASDNQSSRCRRPLFTEDMRQRMSEQLADSLNLDDVHTILTKIDGQCESQEEETNTNFTTRMGPFGAFRVVQVEMDLPEAPMDPIDEPLPRVEDSTVNVGLDMSLDDAFSNDPLMECLFGHVNVDVSADLDAQDFFAATLPSAENDGISPQSLSGGFLMGPSPLVPLQASLLSSPEIRYAPSVTNLAPPDAPLLLSAYTKNVTQLFTPIQLEKSPWSMLYIPPAMETLALLTMGELANNTRMSIFYAILATAAFTQRLSSLTRSASEYWQRQAETFATEAQNYLKRALHDASSSVKKVKYKDVLIALLCMGTVSAYQGSTERVRRCLLDCENWVRFRGLPKTRKSRKVRLLHHCYVYLRIFQESTSVLPVSNVEIESDYASPDTVRSIASTRSFRLRQWEGRLDQRMSELKEQHQGENDLHLEIPGQWDSTMYPHVFGLPESLLFLISQVTRLGNERDLSDLGSYTGALDFKQFSARARSLERCISTWRPPSVSDADPDSIIAQTNATIVRLMISAIHKALIIFFYRRIYDVDPMILQDKAWQVRDALAQVARDDMPATRVTAPFLWVAFIAACEALDPTLQDWFAGWFETSARKSGLGTFKLALRIARQVWERQRQHLNSNASASWPQIMRESNLSLFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNJ0</accession>
    <name>A0A8G1VNJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_367990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517851.1">
        <property type="nucleotide sequence ID" value="XM_025655844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNJ0"/>
    <dbReference type="GeneID" id="37159246"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="236"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="582" mass="66934" checksum="3D744E60633D4B76" modified="2022-01-19" version="1">MRFAKDSEAMMKSLRDQGSQFQNFVRERHLYYDGWTLVHGPTGDPDSEHRIASEHIDGDVIIDFLEGYKAESSLRSPSFDGLDSFDDSDWPVGDDELYIKHWINGSRSKLLGEITEITQRGEWFGGWLTKRRLKEDRFLNAWEAGTMRQLGGDDLALLPRRVIAYAFRERKFVMVDIRGLKKKDPAPQNVFKDLKIDPDHKRMVRSLVKTHFARQEIQKHQPNASLNQDLIRGKGSGLVILLHGVPGVGKTATAEAVAQANNKPLFVITCGDLGFTPKEVDASLKDIFRLAHLWDCVLLLDEADVFLSRREVSDLKRNALVSVFLRVLEYYSGILFLTTNRVGTLDEAFKSRIHVSLYYPPLDKDQTLAIFDLNIRKLNDIQRAKQMLQVDGDSSALREPELAINRASIMDYANWHYDTHEQYERWNGRQIRNAFQIAYSLAHYEMERDSQDQWDEDVEPNIKKASNGPQATRTLDYRQFVSVAKTIERFDDYLYDAIACTDMDNARDNGLRADDHDPNMNHRPDYHTIRHDPVHLGVGTAAKVWRSGLDIQVPPDQIINLQRRIQIYNQNSDQGTQRCSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNY4</accession>
    <name>A0A8G1VNY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS quinate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_415364</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518153.1">
        <property type="nucleotide sequence ID" value="XM_025657684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNY4"/>
    <dbReference type="GeneID" id="37161086"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000558">
        <property type="entry name" value="MFS quinate transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF43">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16230)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="20"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH60231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="528" mass="58522" checksum="D8863C281CC2D297" modified="2022-01-19" version="1">MGWKAIDWSRWTTNPYYALVIFIIACGSIPKGYDEGGYSASVKLESFMVDFNLLSSNWTNDATGLANRKANITSFNVLGAAFGALFSLDLNDRLGRVRTWQLSVLVWGSGLFIQVFSSGIYGLLLFARIWSGLGAGALTVTTPLYLSEIAPARTRGLVVSVYMVVLLTILTVGFFVNYGADLHMAPTREQYRLVQSIPLIPTGLAFFASFIVPETPRYLVSKQRPEEARAVLARFRGKDISDPEVDEEFSTIEAQVRAKAADLASVSHWQAFKESQLNPNYRQRFWLLMTMQTIAQWTGGNGITYYISNIFQYAGITGNAESLISSGAYGIVKVVFTLAFTWVFIDLLGRRRCALTGLSLQLAAHIYMGAYMGLQPGAAKNENASNAAIASVFIYAVGWSIGLCTIPYLYGTEIFPTRIRNVSYALSMTLHWFFQFAVVRVTPNMFVSLNVWGAYLFWAIICFLGIIILGIWMPETKGVPMERMGDLFDCPWYLRWRAKPKDVASSSASTAGEGSVDAKQVDSKSVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPC0</accession>
    <name>A0A8G1VPC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_476331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517612.1">
        <property type="nucleotide sequence ID" value="XM_025662772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPC0"/>
    <dbReference type="GeneID" id="37166174"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213:SF2">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="190" mass="21538" checksum="FB218DE4919DD9AE" modified="2022-01-19" version="1">MPPTTAPHPDQRGIEPHPDLPHNTAHEVDYTPHPENSVPLPPSRQSIQDHIIALYCGSASAEDMSVYAEQAVYDDPFSYCDTRYKIAGQWYGIPKLFSKSENLGTEVVSNTDDEMVWKQRQRYTFRGIGASRTEDSLVSLRLQDGEDGERVVYHKDMWSEKDYDHQGFGALMKKVNGDKLTGITRPPEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPQ9</accession>
    <name>A0A8G1VPQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_484972</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CLASP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519156.1">
        <property type="nucleotide sequence ID" value="XM_025663282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPQ9"/>
    <dbReference type="GeneID" id="37166684"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060172">
        <property type="term" value="P:astral microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902903">
        <property type="term" value="P:regulation of supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="15">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="13">
        <location>
            <begin position="92"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="15">
        <location>
            <begin position="394"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="230"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="623"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="775"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="230"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="288"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="644"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="817"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="847"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="862"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH61234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1138" mass="127610" checksum="704C561248691EDE" modified="2022-01-19" version="1">MEPKAVELLEVLRNMNLAIDAKVSLLHSMKSDIKQKNVPENAIAPIFDALRQSISSPHSTLLSAGFSTMGHFLKRLFIQEQHSIVASQARNIYPLLLERLGDHKERVRAQAAQAFTDFWPAASHEVEQHVLGTALIGKNNRAREMSMIWLANMAKQYGLLFRPYVPSLVACLEDADSAVRDTAKATIIELFQNAPAHAKADLKKQLSELNVRKSIVSIILTNLGLESDESEHLSRPASRIDQRPVSRVDQRPASRVDQRPASRIDQRPASRVDQRQTLRIEQGPISRVEQKPASRDEQKPVSRVEQKPVSRVEQKTASRIEQKPVSRVEQRPASRVDQRPASRADQKPTLRIDQRPASRVDTVTQDTLVRPASQFGTRPVEPTPSDVEPIIVSSAREIDEFVRLMTPYFEGRESEDNWVNREKSVITLRRLTHGNAPHAYSQTFVAAIKSILDGIFKVVNSLRTTMGTNGCLLIQDLARKCGPRIDPMMEIILQNLIKLCAGMKKITAENGNLTVDIVIGNVSYTHRILQHVYAASQDKNVQLRLFSAGWYITLINKQAAHKSSIEHGGGIELIERSLKKGLGDANPGVREAMRKTFWTYHSVWPQKAKFIMSDLDSKSRSLLEKDPANPAAGNMQSADRHASKSSTTSQKATTSSTNVIPGRSALKQAIAAQKKAHLAPKTAMTPRPESAPQVSSLSSAPMRPMGKSRRLEPTRPATPDQKEPVEKATNQVVIYEDTKEKNDEIADEAAERNVSITSTVVHHPIVVTDPLRLREIPLPKPSSPVAKGNENSVPKETKPPTTPSVPRDAPKNNALEELSKNEPDHRDNRSPQTSMPRLPSLHVPRTRPSTGPSNDTATHRCPKFEAAQKRFEERRRSISPRSKDPMKARQTLEKGIPRIHSKSMDIHGYHKLQGLIEFHDRLFDDEEQYSELLDALLGELERAPDEKQQYFGRPLDPKAQVLITVRYTFRHMKRLVDNGGSTMSLGEYASRIIKSIIRARKNYDTTCYMAIVLNETAEEMVSAAEFGDIVKAVVDVVSAEEASLNDRAILMVFNILTDILRQMTSRAARFPMDVLERLGDLASKFLTSEQANIRQKVTQLCVHLHTMTADDEKFWKIIGQVSENTRNLLLYFIAMEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQR9</accession>
    <name>A0A8G1VQR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vesicle-mediated transport protein Vid24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_185675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518964.1">
        <property type="nucleotide sequence ID" value="XM_025654383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQR9"/>
    <dbReference type="GeneID" id="37157785"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="338" mass="37766" checksum="069FE55D61C371F8" modified="2022-01-19" version="1">MPTPSDNTPPLNASIAEEISARSTCPPEVDRESLHTREEGPYPWVSAWERRNTSDDAPDNTFSPTGPSNHTALTPSDGAPFTSTDADPVTGEPVARAPTKGVGRSEDEPAAGRLSPAAESSCSSGPVSPVTPSSATSLLSYEFSNIRLLPNYSSSFLRPGSRFTGTQQSDSHVYSVDVEIKHVDMLESYLCGYLRIQGLTEDHPTLTTFFEGEIIGTKHTFKTRNEAWGATEKTDMQHWGRFPAWRSQAKQAKKPDFTFRNFAQREHLFMRWKEYFLVPDHRVRSISGASFEGFYYICFNQVEGTVAGIYFHAKSEKYQQLELRHVKDYGCAPAMEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQZ3</accession>
    <name>A0A8G1VQZ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_418572</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517195.1">
        <property type="nucleotide sequence ID" value="XM_025657825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQZ3"/>
    <dbReference type="GeneID" id="37161227"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH59273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="668" mass="75367" checksum="1C39EE7FE56C2C37" modified="2022-01-19" version="1">MSSQSARETIQERRHRLSLVPRACEGCKVRKIRCDRKIPCSNCQASKITCRHPNDRSRNQLQTDRIAHLEGLVDSLDKRFREVESRLAALQSPELNSRVQSVSNQNIITADPGRVEGCQAFEGDTSFASQSLHASNIAHITALSASIGNNTPDIEHSINHIRKSLYDSQELSKKGFYLSKSSQHAIQVEPIPATLVTSLLRRMRARHPIFLSSYAISDLQVVEDLCRSVLSGPSRASVGQVASMHGVLFFVLKELIAMKDELCQRFDLTTHLDHCEKVFAATLETYDVLVVPSFENILALTMGMVKAQGEAKPALYWTLVSAASTHCQSLGYHRETTYRNILSGKADNIRRLFWTIYVFDKNMALLLGRVSSMQGVKIDVRHPAISIDPGRRAWDESFIMGIRMAEFQDRIFTNLYNLATSIKDPSERKQLIQDLASDMEQWHSQLKQIDPEGVNNLQVFNMSRTNWDISFYSTLTMLLHASSTTGEELQISSRCFNAARNGLLAHLNSFPQYQSSKLLSDGEYFNWILLFSSLTPFLVIFLHAISAKDIQSIELLTQVVRSFETFRKVSQGAERLYQICATFTNIAEKLLQSQQLSVGIYNEQEDSLRLPDTPGDTSMFHAEDLQNVLDMDNVDGATSLYATELLNEFLSGEPFMWNRFDLEVGNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQZ4</accession>
    <name>A0A8G1VQZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_434955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520268.1">
        <property type="nucleotide sequence ID" value="XM_025658493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQZ4"/>
    <dbReference type="GeneID" id="37161895"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000013">
        <property type="entry name" value="Similar to TBC domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000034">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000072">
        <property type="entry name" value="TBC domain-containing protein C23D3.03c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053949">
        <property type="entry name" value="SBE2/SBE22_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22874">
        <property type="entry name" value="SBE2_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="447"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="874"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH62346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1196" mass="132776" checksum="EFC988F94E43F3A4" modified="2022-01-19" version="1">MTTVCTTTPNSPPDLSGSKSSKSSSFRSSSQHSGPEAIFTDISNFEEVDLQDDVHVSYTKGATPYVQNAGITRASAAIMQKSAVATTRDLTATKTKTPYPTGKQVNGTLAQPGRGPKHRPGNQRDPASTKQSALQVTKPHRSRSSSPLRPTSSLSSSPSTHSLSLTPVNTHTLNRKPSWQRPRKTVQDLEDEYHDSDEELPEDASLWNVPISPRPVQDRAPSRASSPNGRSPGPRPLPLSHSVSDVTVPRSPSGSRSPTTRNNRSSSAGPERGQISPRNPRAYSYNNMMSDLSEEAKIITEALEFHADERQRQRGERLQSGLSSLRSSEESKRGSKSTIELPPLQKSNIMIDPLPPSKEKEKVLTRTRPSWLPPKDQKEEKRHLKEYKRMMAQAKEADKRRAAKAASAKCEKDNTRETLQQIWDEYVYPNWDNVINETRTRELWWRGVPPRIRGSTWQRAIGNELALSEETYKKALQRAKDVRARPEGDSGETNKRMRDWFEAIDADASKAFPDLNLFQVGGPLRETLIDVLQAYSMYRSDVGYVSGLHTIAALLVLQFPSPSSAFLAMANALNRPLPVAFLTLDRGAIGRTYSLASATLKYKFPRLMTHLHETLRLSDEEIWEPMFRSLLTNGLDLERLSRVWDCWVFEGDRIMIRAAVAILGCLQPQLFGYTKPDDQSRKAVQDILSWGPRQGGTRTQERHSAPAATGFGGGQMASGMGDYWMLGSAGDEDGFMHEVREAGKIIIFFFFDEHITMAGWQEQLHSRSSSLAVYRVVYSHELRVVCQEFTLLHLYIKMPSTIAIAKNYLCFKLPFSEYSFSIPSVPFPWHAHTQTHTTATISEADTDISNISEESPLLPHHQQNTPQSLKDKYGTCTTILHYGTSSSVRLYTNTTTTTTNKKNKKLHVLKTLRPTPSSSTKQTLKSTLESLLSSTLYHPHLLQTIDILPNSRGETCLVSEYCELGDLGTYISSSSTSHGDSVMGVKEADSIFYQIMSAVEFLHEMGVVHGCICAENVLVSSKDGNGNGVCVKLGDLGDARVLDSQLSHDHIGVKDGDGGYYAAWKEDVYPLVRGLSMGIGKFEELELEGRCDRGKRRSNPYAAPEVLHPPSPSPYSSAYCRRGYGSPSLGVAGDDDPRAVDVWAVGIIYLVLRLGRILWRSASEEEDGRYAEYLAGRKRREGYGVIEGLGGSGVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR68</accession>
    <name>A0A8G1VR68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_7561</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520686.1">
        <property type="nucleotide sequence ID" value="XM_025665640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR68"/>
    <dbReference type="GeneID" id="37169042"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="312"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH62764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="401" mass="45603" checksum="868025297CC6F173" modified="2022-01-19" version="1">MTTMDLRVGNKYRIGRKIGSGSFGDIYLGTNIISGEEIAIKLESVKAKHPQLEYEARVYKSLAGGVGIPFVRWFGTECDYNAMVIDLLGPSLEDLFNFCNRKFSLKTVLLLADQLISRIEYIHAKSFIHRDIKPDNFLMGIGKRGNQVNVIDFGLAKKYRDPKTHFHIPYRENKNLTGTARYASINTHLGVEQSRRDDMESLGYVMLYFCRGTLPWQGLKAATKKQKYDRIMEKKMTTPTEVLCRGFPNEFSIYLNYTRSLRFDDKPDYSYLRKIFRDLFVRESFQYDYVFDWTVYKYQKNAAMIVDANKKDKEAEEQQRRQGVAAAAPMGTPGAAKPGAISSQRRKVIERGTLDNTPETNRAVGGSDRMLRSASKVAASGAYGPAGSRAKRDDGHGSQWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VS16</accession>
    <name>A0A8G1VS16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_502359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520402.1">
        <property type="nucleotide sequence ID" value="XM_025664191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VS16"/>
    <dbReference type="GeneID" id="37167593"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="128" mass="14361" checksum="B75E06ECF0ED4E63" modified="2022-01-19" version="1">MNVKIYSASQVSLRQYLLFRTLVPPIVLPNQLNVQNLGISHHMMQAIQWLNSLSFNEYIACFSNRQAQTTGWVWGGTDRLFRVMAMQQQEAIRNLTINGINCGVSESTVNTAFLSFLNAISDLGPQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VS76</accession>
    <name>A0A8G1VS76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="8">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_444006</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="8"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520582.1">
        <property type="nucleotide sequence ID" value="XM_025658921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VS76"/>
    <dbReference type="GeneID" id="37162323"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000003">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH62660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="717" mass="81285" checksum="9B6A976200A2C0CF" modified="2022-01-19" version="1">MGHLVTLATCSLNQWALDFEGNCERIIESIRKAKAAGATLRVGPELEITGYGCLDAFLEGDTYLHSWEMFARIIDHPDCQDIVVDVGMPVRHRDCKWNCRVIFYNRKIILIRPKMWLANDGNYREMRHFTPWQRPREVEDYYLEQIVGKITGQYKVPFGDALISTRDTCLGLETCEELFTPNGPHIPYGLAGVEIFSNSSGSHHELRKLDTRINLITQATKLSGGIYLYANQQGCDGDRLYYDGCAMIVVNGNIVAQGSQFSLNDVEVVTATVDIEEVRTYRSSASRGMQASMQSPYVRLDLDTRLSRRDEDADPGYAPSETLEPRYHVPEEEIALGPACWLWDYLRRSGAAGYFIPLSGGIDSCATSIIVHSMCREVVKAVQEGNEQVIKDVRRLCAEPADSTWLPTTSQEVCNRIFHTSYMGTQNSSKETRDRAKVLAAEIGAYHTDFNFDTVITAMMNVFTIVTNFQPKFKVHGGTRAENQALQNIQARLRMVLSYLFASLLPTVRQRPGGGGLLVLGSSNVDECLRGYLTKYDASSADLNPIGSISKVDLKKFIAWARDSFDLPILDDFLTATPTAELEPITATYVQSDEADMGVTYAELSVFGYLRKVAKLGPWSMYERLLHMWGNEYSPREIYEKTRHFFYNYSINRHKMTVLTPSYHAEQYSPEDNRHDLRQFLYPSFSWAYKKMEDSVQYWESKGWTTGKAQKKSVKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VTQ1</accession>
    <name>A0A8G1VTQ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_362468</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519970.1">
        <property type="nucleotide sequence ID" value="XM_025655632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VTQ1"/>
    <dbReference type="GeneID" id="37159034"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000009">
        <property type="entry name" value="CTS2p putative chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF228">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="29"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH62048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="380" mass="42115" checksum="EA8D188BF6EFCC6E" modified="2022-01-19" version="1">MFSGSSLFPHWRRKAAERSSNSSYEVPFFLNAAYYPNWRIYRKQPPSALRLGFISHIFYAPYTETVVNQPAFFVHRVKEDGTVYLSDEWADAQMPVDGTNGCLRAFAQLKPQYSKMKLILSVGGGGKGSENFAQVARSQSRTETFARSARALVDQFGLDGIDVDWEYPSDPQEGSDYIRLLARLREVLPAPRYVLASCLPAGPWALRNIDLSKAQLYLDLINIMAYDFSGPWENQSGHQAQLFSKHPAAISCQNSISYILNQGVDPKKLLLGIPAYGRSFLGSSGVGQRYVGCGGEDGVFDYSQLPRPGAKEHHDSSLGAAYCVGGDGGFVTYDTPQTVQQKAKFVTKMKLGGLFYWHIGGDARGPRSLIETGYNTLHDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQ17</accession>
    <name>A0A8G1QQ17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_473216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825095">
        <property type="protein sequence ID" value="RAH51718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509640.1">
        <property type="nucleotide sequence ID" value="XM_025662607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQ17"/>
    <dbReference type="GeneID" id="37166009"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034094040" evidence="1">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH51718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="121" mass="12913" checksum="AEE3D20D620B1CD7" modified="2022-01-19" version="1">MKFILPAVLFLASAVSAQNTVLDYSDGIPLCCTTHDYVSEADDEVIQQVTSAFESDGGGAWDLGEAIAGECQTAFPTGFAGGNRTDCPEDLTAIWCKKHAPWTLTINGTSTPRDAHGQCHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQW2</accession>
    <name>A0A8G1QQW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_408919</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825090">
        <property type="protein sequence ID" value="RAH51954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509876.1">
        <property type="nucleotide sequence ID" value="XM_025657420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQW2"/>
    <dbReference type="GeneID" id="37160822"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030626">
        <property type="term" value="F:U12 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000572">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045164">
        <property type="entry name" value="RBM41/RNPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105:SF0">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="25"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="118"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH51954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="196" mass="21019" checksum="9539FB579269FECD" modified="2022-01-19" version="1" fragment="single">MATRVIPTRGGGQGKPASATGLPNQTLYCTNLPDKLRKHDLRLSLYMLFSTYGTVLDVVAMKTQKMRGQAHIVFKDVQASTQAMRALQGFEFFGKQMKIVYAKGPSDVIARLRGTYSVPTTTSAGQTTGASTELQKSIFSGPPGSAALPSKPSGEVNGEAQAGQGVKRPREEESDEEEAPMDEDSDVPMEASSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRA0</accession>
    <name>A0A8G1QRA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_464105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510086.1">
        <property type="nucleotide sequence ID" value="XM_025661968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRA0"/>
    <dbReference type="GeneID" id="37165370"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="283"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH52164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="631" mass="69760" checksum="6FF91A561E6F5871" modified="2022-01-19" version="1">MDRRKRESRSYVEQLEKRIEKMQEQLESLTRSGTQIQRGVENTRRSTSPGSSVESNTNYGDPEDPTDGDNIPEMPQVPSDKGPHPPVENDQSIVIDAQDGKMRYFGASSAFSALTNAELNGLEAQPDIGVWRRAPQRSANPWQLSSWIPQILRDGLERRIFEPLPCKDTTVQLAREYFATFNQALPLLEEASFMKSVDRQYSWNPDNSASWWISLNIALAISYRERAHASSDASDNWKKSLGHVKNALNAVVDVFLQNTDIAAVQGLLGLALYFQGTPNPQALLMFAAAAMRLAQSIGLHRENGSGASPEAEHRRRVYWIAFILDSDISIRVGRPPVQDLEDYDTHLPTENPPDGRGVLTIDGTRMNYFRLLAQLAQIQRLVYRKLYTVTVCVFQANAIERSRQGTDEGIAPIVSRSLDAARSALDLLSHVPSLGSTYKWNIIYFPAAACVPLALRILAQPAHSDAGDDLSVVQDVIKFLTCTSSEEPNTYVDFVLGMCSDLERSARRAFLTAQPARNHHPAVIQNNENDRPSISSLGINQTSAPNISDALPTPFGSASAANMGSAQFTNVTPQGPYPDIGFLGPFNDVDQAANWQWSLPPFWNWQDLLSGAPSFPVVPGVDVPEANMPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRE2</accession>
    <name>A0A8G1QRE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">R3H-associated N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_453587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510853.1">
        <property type="nucleotide sequence ID" value="XM_025661086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRE2"/>
    <dbReference type="GeneID" id="37164488"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02325">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025952">
        <property type="entry name" value="R3H-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039629">
        <property type="entry name" value="R3HDM4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019:SF2">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13902">
        <property type="entry name" value="R3H-assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H-associated N-terminal" evidence="2">
        <location>
            <begin position="110"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="383" mass="43197" checksum="7135A04A26CE0A31" modified="2022-01-19" version="1">MAIHPNFPSETNPRGSLSPQQARAISAWTEQAAASLESLTLSESVPITDSNVVFSQSTPTRASVRGTTVSLSIPLDDPVPTVGSPSAPKVKVLAQPTKETQVASVSFRRREPLRRDSLKRREALLKGKDGSRRRQRWENDRLLNNPWAEPPSSKDWDIQATHTRHDPMPYYLAPLWDNHYAHLDHRSSQQMETRTEKHRVPKELRQRLKHARAARGILQDIEEDIRQFIQRWNEKQGLLKQEGLADAPQSSDSESEDEIVFVGRNGLMHDSSQRRARLQKMREAMSAHHEHDGQKMVFESLVDDRAAGFGRWLVHSIASYYGLHTWSVTVGEPARREAYVGFYPPAPGSRAGPVSPPAGSKACRQEAMIQLGDELPQPLWTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS59</accession>
    <name>A0A8G1QS59_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_472464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510560.1">
        <property type="nucleotide sequence ID" value="XM_025662554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QS59"/>
    <dbReference type="GeneID" id="37165956"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF12">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="450" mass="49824" checksum="DA0836D3814AA616" modified="2022-01-19" version="1">MAYPICFELDRTLLFIRPKGPIAVPTTTLKSVGAGYCGYSYSEPLHSSGERIIAAVAEPSEFKRRAFGERFIWGTGKPLEGQAFSSLEDFISHGVNRRELERLTGTVTDSGIDAVFVCLLDELHAIVVQAVAPLVMNYASRLYIMCEKLLATQLSDLLCIYGILMESWEMLQTEAIFAVGLVLWYSRPQVMLWKLSCHDIDFLFWLLCLPASIFNPEPPHLSSKVISSGRLHFFRQANKSSGAGTATNCLRCPVETTSLRAGNRDRPIDAIGLSSAAKCLLEVLGEDYDDKTPVSQVSRKNWYGCCVWEPGNDECDDQMVTIELEGELLPFAQIQTNDNALQKLPSFHMVALTDAISRRRGRKSGSTGEIVYDAVTIRVSDFSSGFEVVYNMPCAKGGHDGGDDGLALSLVRAVAKVKRGNMGVSEAQRSFLNCTVQEFLRKNYIKINKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS76</accession>
    <name>A0A8G1QS76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_454421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509789.1">
        <property type="nucleotide sequence ID" value="XM_025661283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QS76"/>
    <dbReference type="GeneID" id="37164685"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH51867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="75" mass="8223" checksum="B76E5F7824B53E32" modified="2022-01-19" version="1">MSCQVSCRFFPLRSIILPSQTYQYFIDATVEGTKRVSVTHPISQSDTAGDAAQWVNIQTTGPPPPPIATLEESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSA6</accession>
    <name>A0A8G1QSA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Myo-inositol-1-monophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_168949</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510855.1">
        <property type="nucleotide sequence ID" value="XM_025654275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSA6"/>
    <dbReference type="GeneID" id="37157677"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000026">
        <property type="entry name" value="Myo-inositol-1(Or 4)-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000021">
        <property type="entry name" value="Myo-inositol-1(Or 4)-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF2">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="352" mass="37997" checksum="D30D742563494E7C" modified="2022-01-19" version="1">MGSTNPYAKELQIACLTVQRATLLTKKLLEAVDKGSFDKNDATPVTIADFAAQALIIAAIHRAFPDDEFVGEESSDALRSDPALLDRTWELVSSTRLLDEESDALLYAPSSKEEMLDLIDLGAQGNCSKQSRAWVLDPVDGTATFIQGQQYAVCLSLVENGYQKVGVLGCPNMNLETGRLHENIVDRDGYGHQVFAVAGQGAFIRQMGTGALLPSRKIEPKAQITDPKDIDFVDCVSATSSDRNMHARLASHLGAPWPASTDLWAAQLRYIAIAVGGCNVMIKIPRNPSYRSKIWDHSGGMLIAEELGCTVSDLAGNPVDCSLGRTLSGCYGMIVAPSSIHSRLVEAVKQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSL3</accession>
    <name>A0A8G1QSL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_463406</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510806.1">
        <property type="nucleotide sequence ID" value="XM_025661924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSL3"/>
    <dbReference type="GeneID" id="37165326"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000051">
        <property type="entry name" value="Protein tyrosine phosphatase (Pyp1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="168"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="424"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH52884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1035" mass="115210" checksum="83A2A6E9158D7DAF" modified="2022-01-19" version="1">MSAMTGTRSPTSPWPPECQNLQLEGSSTPSALFTLRESQMSPLGHGINPHNSVAERSGPNYFSISVESPGNPRRSRDAISYTQPPVSSPKAQLLSKNKAFEDYVGLPKTGVVADDEHRESPVFRLSWNPSLQRRSPIPARQDASPLRQTSTHGHGISVERCAELLGSSHRDIMLLDVRPYAHFAKGSIRGSLNLCIPTTLLKRPSFDTQKLTNTFTNEADKESFAGWRRCRYIIVYDAATSDMKDASSLMNVLKKFTAEGWSGEGLILLGGYKAFSSRFPTFIQGQQVPVSDSPAGRPSRMHIDLPSVAPVAGGCALPESSHAAIPFFGNIRQHMDLIGGVGQIPLQVPHSFSETKKRLLPPWLREVSESSDKGRKVSEKFLGLEKKELERMKKALSYEKSTDAATMNDSSENFRVAGIEKGTKNRYNDIYPFDHSRVKLQNVSPGDCDYVNANHMKAAYSGKHYIATQAPVPDTFNDFWRVVWEQDVRLVVSLTAEVERGHVKCHPYWESGNYGPCQVNNFSQKFIYLDAQDPQPTDMELDKPDDSGSPYIIVRHFGFSKQLFRLLTKHAFQQLYGAQYHADRVIYDFGNDVLDVKASTFSSFDHQTLALVARGREKVYIFRIEHGQLRPLREINLPCDRPGICEVLQTAFDGDGGLYVLQRFVPAMDVTDTNANHPFIKQAMQSNINGMNYLSCHSLDSPGEPVRVCAFPDHANYKPLALAAMQGGSFAISWQHNYDCSDNEVVLYTASTNPHSSAKSGVIDRFAQSRNTRNCLVGKGPVVGLAFNDRSSQLLYRYRAQALYGSFQKIDLLPFPTQSVLYENSCPVQFSDYLTLLFGIGIPFFGTHETRVQNGLSRCHWKYLSFGIATHREEDWTVACLLTSEAICRASNCEHELHLERGRRLPDWTIVARLRGFENSNTSLGCIVAASKLGTRIAVANWKTIYIWALEPGALIEHNATGFYPASSWPPGSEVIDLQPITISLDAVCFQLRFGLGENDLVAITDRGLVYCDLDPSGGSHRTIYQLGMENAPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSN3</accession>
    <name>A0A8G1QSN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_168241</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510830.1">
        <property type="nucleotide sequence ID" value="XM_025654270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSN3"/>
    <dbReference type="GeneID" id="37157672"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="86"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH52908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="357" mass="40049" checksum="A1A848A8F06A171D" modified="2022-01-19" version="1">MTAFNVKDLAARAAQRLAEHRQKTEARGSTFSTEPLPMDRVSSLDTNSMRTMSHSEDEHRHKSKMSRLVQKVRGRFSKRLAKREVIDEPCACCLDIMPAECLISMPCQHKYCSRCLKKLVFTVMPEEGLFPPRCCKQKIPTEVILPVLTPKERTVYFAKVQEYATPARERWYCPAPTCGRFIPPKHLNSKLSSQSCPYCSTTFCSGCRCPEYNNSTSTGKKDPGFMAVFEDPRLGKAQRGLKCGSLVDLLFNCDHVTCRCKAQVCNLCRNPWLSCTCAKPGQRPIDFLTFIIGHSGVNKDQEAELAAVVAAILCNERLRDEELAKTQSGMKEKAGSANRSRASLLIPQQATRARRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSU9</accession>
    <name>A0A8G1QSU9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Endoglucanase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_472150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510935.1">
        <property type="nucleotide sequence ID" value="XM_025662535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSU9"/>
    <dbReference type="GeneID" id="37165937"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.180:FF:000004">
        <property type="entry name" value="Endoglucanase A eglA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF10">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034636225" evidence="6">
        <location>
            <begin position="17"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH53013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="239" mass="25790" checksum="E3B03040B3827AC6" modified="2022-01-19" version="1">MKLSMTLSLFAATAMGQTMCSQYDSASSPPYSVNQNLWGEYQGTGSQCVYVDKLSSSGASWHTKWTWSGGEGTVKSYSNSGLTFDKKLVSDVSSIPTSVTWSQDDTNVQADVSYDLFTAANADHATSSGDYELMIWLARYGSVQPIGKQIATATVGGKSWEVWYGTSTQAGAEQKTYSFVAGSPINSYSGDIKDFFNYLTQNQGFPASSQHLITLQFGTEPFTGGPATFTVDNWTASVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT24</accession>
    <name>A0A8G1QT24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_472249</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511055.1">
        <property type="nucleotide sequence ID" value="XM_025662541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT24"/>
    <dbReference type="GeneID" id="37165943"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="13"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH53133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="511" mass="56119" checksum="74CBF0E904BC1CC8" modified="2022-01-19" version="1">MALHGHALSLAQLILVVCPAFFLFGYNQAGVGGLVSVEDWTTTFPEIDTIHTSGAVKSHNLTVQGVVISTFTLGALVGSLSCSLIGDILGRRKVIFAGSLATLIGEALCCSSFGLAQLIVGRLIIGIGIGMLSGTVPVWQSECSSAHNRGKHVVLDGLFISAGYAITSWVNLGLYQVKTGSVAWRVPLAIPGLVSLIPMFSIFFLPESPRWLVQKGRLEQARTTLVSLSDASVRPEDLNGDIAAIQSILESHSRGVSIMDIWRPNDEKLLFRFALCIMLQFYQQMSGGNLISVYAPVIFEDNLQMTSMMSRILAAATLSWKFFSCFVAFYCVDRFGRRVVFIVSGSGMSLCMLALAITTSFPHTNKPASIISALFIFLFNFFIPIGFLGANFLYCTEVAPLRLRVAMASISTANHWLWNFVVTMITPVAINNIGYQYYIVYAVIGACIPISVYFLYPETMGWKLEDLDILFKQGLSIRGIVRSSYRPRNCDAEGRFSLEKSEVEEVEHKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT44</accession>
    <name>A0A8G1QT44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_503958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511723.1">
        <property type="nucleotide sequence ID" value="XM_025664270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT44"/>
    <dbReference type="GeneID" id="37167672"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF3">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="34883" checksum="E66CC30376A04C30" modified="2022-01-19" version="1">MNQIQQQQQNPLVGSNGTTLPVVVDTRRPSGRPKHNSYTDLMKPGESWEDLPDAAERRRIQNRLAQRAYRRNMRDRTKEVELLKSQVKNLQEAMNSNSSTPKDSSNSGSISASASTSDGDDRPTRASSQVSTSSVSPGPRDPPSTYFPSPDQEMLGDGLSWPTDLDHDFTNCFDKTKDITATVTSMPASASPSTMASTASAQNAMRWLESDVYYPFPPPSPPNVDPMLRSMPSNMSDTQRRIASGCSLSSRDPEADEPLIHIAISRGTIDTLQLLLLTYPISVNVRDRAGYTPLQRAVITGRTDMMKLLIEHGADAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT67</accession>
    <name>A0A8G1QT67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_473117</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825092">
        <property type="protein sequence ID" value="RAH51825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509747.1">
        <property type="nucleotide sequence ID" value="XM_025662603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT67"/>
    <dbReference type="GeneID" id="37166005"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="46"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="693"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="695"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="696"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="853"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH51825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="922" mass="99745" checksum="67531E8DACE57F71" modified="2022-01-19" version="1">MDPADDYLPAIDDLKPETFHDDNAGAAEGLDDSIETTNPGKAVWLIACTVSMGGFLFGYDTGVISAVLVSLGTDLGQALSSNDQELITSITSGGALIGAVLAGMTSDKYGRKLAIYVGCAVFFVGTALQATAFSLAQMVVGRLVVGFGVGEAAMIVPLYIGEMAPARFRGRLIVFDNICVTFGQLIAYALGAAFTDVHQGWRYTIAIGAVPAIALAATMPLCPETPRQLISHGRDDEAKRVIRKIFPQATEQQVVNKIRVVRHSIEEVAASVSDKSLWWQMKQLFTVGANLRALATACSIMAVSQLGGFNTLMYYSATLFSLVGFNQATAVSIVVGATNFVFGFPNFAFIDRFGRRSMLLITVLGMSLSLVVVAIAFHWIPVNSDLSVTGPHEMTWASILLLVALIVYIAFYSAGVAPISWVGTEFLPLEVRALGTMLNTVTCWGCNIIISSTFLSMMKAMTPSGVFAFYAGICFLGWLFVIFCYAEVHNMPLESVREIYTHGFGTAILARTLDPPRLQASAVGSSPDSSALNLQIGSGPSAVATEDQKGTQHRPTTMAHSPFARELQVACLAVQRASIVTKTMLAEADKGSTDKADASPVTIADFASQAILISAIRHNFPSDKFVGEESASALRNDPALADRVWQLVSKTQLHDTESEEIVAAPSSLEEMLSIIDLGGNGEGARHTRTWIMDPIDGTASFIQGRQYAVSVALIENGEQKVGVVGYPNLHFHSTEVHEDTVDRNGYGIMLSAVRGHGAYKRPMSKERLQPAVKVYNVLARTDTGQPDLVFAESMESPYIDQRLHQVVRERLGVTKPITDLWSMQAKYAALVVGGCNVMVRIPRSPEYRAYAWDHAGGMLVFEESGGMITDLDGQPFNYGRGRTLADNFGLVAAFPEFHSRVLELAQEIRERHKEEGVKDNTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTV4</accession>
    <name>A0A8G1QTV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_141309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512128.1">
        <property type="nucleotide sequence ID" value="XM_025654075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTV4"/>
    <dbReference type="GeneID" id="37157477"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="127" mass="14042" checksum="4B3F888633B39106" modified="2022-01-19" version="1">MSVTQQIWPSLIHAPTIYFQGRTRRNGSIADMVARNAEKWPGYQSCGSWVPGSSSKHGVQLSTDVSIFALGNRTRTVVTKSSLPKVGGEEPLCNPHIQYSPKVFKDGLGSYGWIHDNISGLLRWVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUE3</accession>
    <name>A0A8G1QUE3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_151506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511684.1">
        <property type="nucleotide sequence ID" value="XM_025654148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUE3"/>
    <dbReference type="GeneID" id="37157550"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH53762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="268" mass="29596" checksum="72F84EA588253671" modified="2022-01-19" version="1">MPTQTRFLYSILATLIFLLFTTLGIIYTSTGSLASFSQKFHIHVCPSEPRSTPPIIRKFQSLTPLLGAKSDGSLPHDTNRSWESLLLPENGGILKVRTDNNTITDYGISMFHQLHCLTVLRGLIFPETSQHHGVSTSPSHSGDEHEDAVHWAHCFDYIAQVSGVILLGAVEFENTDNEKSIICAADGTIEPPHPALNKDGNRILVIDGIGHAHQCRDPEPLWRAVRDSGSNPVYLSEVKDTVGHSEFPLKEEATCQSACSMPEPYRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUI4</accession>
    <name>A0A8G1QUI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_509937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trichodiene synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825095">
        <property type="protein sequence ID" value="RAH51730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509652.1">
        <property type="nucleotide sequence ID" value="XM_025664514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUI4"/>
    <dbReference type="GeneID" id="37167916"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024652">
        <property type="entry name" value="Trichodiene_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06330">
        <property type="entry name" value="TRI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01021">
        <property type="entry name" value="Trichodiene_Synthase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH51730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="315" mass="35970" checksum="52E3DE34276BBA12" modified="2022-01-19" version="1">MSTFYYSITHTPIITPFLKEFCPNLPPFAPDEAFKNEVFNKFAAASGLPEDTIPHFVDTGEVLTRCFYPSLPRDLQVSIGVLTAYVFSIDDQCADPEFREQLKPYRSVFLGKSSTNLQYIKGLYNILHDIVSHYEWYAGDMIFKSTMDFVSINIVEAERTGDFMVSPSTKLFPDFLRQKSGIGEAYAFFYFPESDWKLGDYFTLIPDIAGIIEQLNDVLSFYKESVLGNEPGTWIRQTSVCRGISEYEVFQERVDQCLGSIRRLRAACEGNPRLLKAVNEFIKGYPLFHLNAGRYKLDQFGSYDGWLNEKAFGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUK8</accession>
    <name>A0A8G1QUK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_380318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511850.1">
        <property type="nucleotide sequence ID" value="XM_025656374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUK8"/>
    <dbReference type="GeneID" id="37159776"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="390" mass="43232" checksum="17871C4AAD29AA61" modified="2022-01-19" version="1">MRHAVAVSNGVRSIKFHSLSVRYPALRCLSSSACRHSPQHPSSPDALDPRLEDLGNVIRDEYAIIRENYNAPKHAVVLAHGLLGFAELRLAGRYLPGVQYWRGIKEALSMQGVRVITATVPPSASIETRAEELARDIAAGAPGEHHGKCNIYLPLREPLLTLPLGVRTRKVYPSIADTYQCSSGLDSRYMITHLKPTDFKVKSLTTIATPHRGSAVADFALKQIGDDRLAQLYYALDRLKVETGAFAQLTREYMTNTFNPATPDIEDVRYFSYGAAMQPSFWSVFRLSHRLLEQIEGYNDGLVSVASSKWGAYKGTLEGVSHLDLINWSNRLKWLAGEITGNRQRFNAIAFYLDIAAKTSPARGSPFSLALLPPSDTVRLKDPEWVAPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVG4</accession>
    <name>A0A8G1QVG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_428884</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511638.1">
        <property type="nucleotide sequence ID" value="XM_025658225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVG4"/>
    <dbReference type="GeneID" id="37161627"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH53716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="551" mass="61978" checksum="CD618C9DE6B9331E" modified="2022-01-19" version="1">MVNHGPSGGCVTCKSRRVKCDEAKPECHTCQRLNLRCGGYKAKPVKIRFKDQTSKVCNDLASRQAAQNQQLVPCLRSLTDPDPSVPFFIRHYAMMGRDMKSSRGFFEMLVPVYASEKQNSALSLAVTAVASEIMSRWRHECSSRASRETYAQAIQCLRKTIEDRNEWTNPATILAVLALQFYENFAVIYGSKSATSVHHNAALSLLPFTDQDCPDGSLMAHIRRYILHIEISSAVRQKRLLQSTAHSRIGCIEPKIAPGNFGPALDAIGAFVAELHASYWQHAAHKGPMFSTDLPRNWIAEAKRIDEQLLAWAQKVPQHLHPVRLTDGSALDPSIPTYDSICDVYISCQIGTLWNEWRAQRLMLVKIILSSLSTNPPGRFTHPDAGTSTGVEDFARYKYILQELIDSVCYSVPFYLGNQGGWLSIPDLTDPAIRLPSYRLLGNANHQKSAQKSEDEHRSHIIAQGPWHIMSMLSRVVAFFIEDYGQGMVSFLRPGQLQWIRQQFLRVTQLLRIPLEEAGDGRFHPLDRSVHADLDGKIDDLARRVRKGAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVT8</accession>
    <name>A0A8G1QVT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_451627</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="7"/>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513238.1">
        <property type="nucleotide sequence ID" value="XM_025660631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVT8"/>
    <dbReference type="GeneID" id="37164033"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000176">
        <property type="entry name" value="tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
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    </dbReference>
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        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="21"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH55316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="432" mass="47065" checksum="B2CF4BE724E64AB8" modified="2022-01-19" version="1">MGKSSKDKRDAYYRLAKEQNWRARSAFKLIQIDEQFDLFEHENPDKVTRVVDLCAAPGSWSQVLSRVLIKGESFGRRAWVEKKRKEKEALERVRNGSNTTTTSSEDTDMTELKPRKNVKIVSIDLQPMAPLEGITTLKADITHPSTIPLLLRALDPEAYDSTSTSSTPSAIRPPHPVDLVISDGAPDVTGLHDLDIYIQSQLLYSALNLALGVLRPGGKFVAKIFRGRDVDLLYAQLRTVFEKVSVAKPRSSRASSLEAFVVCEGFIPPSIHAGTDALKNPIFGGVAVPPPVSADGNVGVEVIESEDDDARPVKLARFAPAEATLGAASAESSQTEARLLHDDSLASVTPTPLAYKSAGEKFAVENRWIPRFIACGDLSAWDSDASYTLPPDHVSLDPVQPPTAPPYRRALELRKEKGGAYGKTKLGSLGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QW07</accession>
    <name>A0A8G1QW07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_86488</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025665740.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="37169142"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
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        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="16"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="113"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="214"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH54898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="304" mass="33321" checksum="B31C16D73D19396C" modified="2022-01-19" version="1">MESEAFEDMQKGGGTLRTLKDLGAGAAGGIAQVLLGQPFDIVKVRLQTTTQYSSALDCATKILKNEGPFAFYKGTLTPLIGIGACVSVQFGAFHEARRRLEKLNKKKYADSTLSYTQYYMAGSFAGLTNSFLSGPIEHVRIRLQTQPHGADRLYNGPIDCIRKLCNQGGVLKGLFRGQNVTYLREAQAYGTWFLAFEYLMNQDAKRNNVKREDISSLKVATYGGLAGEALWLSSYPFDVVKSKMQCDGFGAQQQFKSMTDCFKKTYAVEGLAGFWKGIGPTLLRAMPVSAGTFAVVELTMRALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWH6</accession>
    <name>A0A8G1QWH6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_88218</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512876.1">
        <property type="nucleotide sequence ID" value="XM_025665756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWH6"/>
    <dbReference type="GeneID" id="37169158"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH54954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="437" mass="48564" checksum="8BDE7C0019BCBBB8" modified="2022-01-19" version="1">MANKAAVPFLVTMMLVTGVCNTILNKYQDMQCVWNCDSPYPKYRRTFEQPVIQTIQMFTGEMGSWLVILMTWLYQRYLAPRLSNNSSPLLAGGYHPVNNTEGLDDEEDYTIRGPEASDDVTKPATLADGRVHLRGYKIFLLAAPACCDIAGTTLMNVGLLFVAASVYQMTRGALVLFVGLFSVLFLHRKLYLYHWLALFIVVLGVALVGLAGALFADNQGHDVTQGSAATVVTHAIREVQATTRSPEALKAVVGVLLIAAAQIFTASQFVLEEWILENYEMDPLQVVGWEGIFGFSVTVIGSIILYLTIGRTEAGRYGYFDAKEGWSQVFHNRAIAMSSFLIMISIGGFNFFGLSVTRTVSATSRSTIDTCRTLFIWLVSLALGWETFKWLQVVGFALLVYGTFLFNDIVRPPLKACLPSSRRDREILLPEEPIEHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX79</accession>
    <name>A0A8G1QX79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_499203</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513281.1">
        <property type="nucleotide sequence ID" value="XM_025664061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX79"/>
    <dbReference type="GeneID" id="37167463"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="88"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH55359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="469" mass="53053" checksum="4E1F7D5F1488FA8D" modified="2022-01-19" version="1">MTMRGLSLSSIRSLRPLTLCPHGISPIHITRMPTRRVFASTASRSTPTGDDSNPHILYEPLEGVERIEYYCPGGYHPIELGDHFHGRYRIIHKLGHGSYSTIWLARDEQNNKYVAVKVCTADSNPKEAGILASLTHPHHLTTNHLGKTMLPSILDTFTIHGPNGEHTCYVTSPARPSLSGLKDGSWVRLFQINVARALAAQLVLAVDYVHARGFIHGDLHMGNVLLKTLPSFDQLSPEDIYEKYGAPELDPVVHLDGKPLPPGVPSHDIAPIWLGAPSEKVTLPEARILLTDFGEAFSSKEAKSESHTPLVSRAPEARFEPDKPLSFSSDMWSLACTIWTIIAQRPLFEGFLATEDYMTREHVDTLGILPPEWWKRWDARPDNFTEDGKPTKRNPYRSWDDRFEDSLQLSRQEVGMPLFDAEERDAIFATLRPMFAFRPEHRSTTKQILESEWMVKWALPEYEKIRRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXX9</accession>
    <name>A0A8G1QXX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_523659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511302.1">
        <property type="nucleotide sequence ID" value="XM_025665373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXX9"/>
    <dbReference type="GeneID" id="37168775"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="35805" checksum="C1E1C2147B44810B" modified="2022-01-19" version="1">MGKPKLTPEPFDLVELIQQTYDDSRIIVFVCLISWIVGRLDLGLTWLFFVLAVCRTYAVVNLTRVQRILRDECKRYHAHKILSRGETVEWVNGVLQRFWHMYQTQICDHIVRYVNNGLARRAITENGTTPQKVVIQSLALIDLPLRFTRVLVHQKHSSPNLIVEGQFQVNLAPHPTHHHLIESSGHPLIDLTIVHDKNSGDSHHRNHDLAVQVRQFKSTGSLKMELDLEGDHPALLQPQVDLQEHPNMDCTIKSISQHHFPLHFAHHVDWRRVVELQLREGLGWAFHRPLALPFTLGERWLFRLEKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ08</accession>
    <name>A0A8G1QZ08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U5 snRNP complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_480751</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511827.1">
        <property type="nucleotide sequence ID" value="XM_025663024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ08"/>
    <dbReference type="GeneID" id="37166426"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="147"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="323"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH53905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="359" mass="39004" checksum="C14A41F8686519DD" modified="2022-01-19" version="1">MSGEKRPAQEAFGSSNQLVVKRKKSDAGLNDSTAIVQSSSQNGALIQSVPRTSGLQAPIMEMNGHSGEIFSVRFDPTAQHIASGSMDRSILLWNTYGQCENYGALSGHRGAVLDLQWSRDSRTLFSASADMTLASWDLETGQRIRRHIGHEEIINCLDISKRGQELLVSASDDGCIGIWDPRQKDAIEYLETELPITAVALSEAGNEIYSGGIDNTIHAWDLRKKGIVYSMAGHTETITSLEISPDSQTLLSNSHDSTVRTWDIRPFAPANRHVRTFDGAPVGLEKNLIRASWDPSGEKIAAGSGDRSVVVWNSKSGKILYKLPGHKGTVNDVRFSPNNEPIIVSGSSDSTLMLGELGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZX1</accession>
    <name>A0A8G1QZX1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_450208</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514736.1">
        <property type="nucleotide sequence ID" value="XM_025660323.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37163725"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14012">
        <property type="entry name" value="PK_eIF2AK_GCN2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14046">
        <property type="entry name" value="STKc_EIF2AK4_GCN2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000050">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000379">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2-alpha kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000821">
        <property type="entry name" value="Serine/threonine-protein kinase gcn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000822">
        <property type="entry name" value="Serine/threonine-protein kinase gcn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000074">
        <property type="entry name" value="Serine/threonine-protein kinase gcn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016255">
        <property type="entry name" value="Gcn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024435">
        <property type="entry name" value="HisRS-related_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12745">
        <property type="entry name" value="HGTP_anticodon2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000660">
        <property type="entry name" value="Ser/Thr_PK_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="15">
        <location>
            <begin position="55"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="279"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="588"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="171"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="701"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="801"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="594"/>
            <end position="602"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="617"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="618"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH56814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1599" mass="180910" checksum="5F8CE9417881F619" modified="2022-01-19" version="1">MPHKQKKNFSNAPKHGSPRAEKKQQQPQQQLLRPDSPSFSPPVVAPTNYQEIHQNEVEALRSIYGDDFEEVQHRRSAWQQSSEVAFKLHLRASSNPDVHLVLLVELPTTYPKTYPNLSLENLDDLRKGARSRIQDIVQNKPKTLLGSEMIYELAVSIQDVLEDVAEAQAQDKDLPSLEEERMEQEAAANQRAELERQEEIRKQEAATAEEERALQQLLEDKVRERAKARLSRRKSRTPGLDANGDTDGVENIPGAITFDPPLAMTDTDQATLVFRAVYGKSLLQIGPGKETYTVRPVVSDNRSHAPLLVLREISLDEKGVEPLLFREKMRSSEDRLEGLKKLRHPNLVDFVGFKITRPLSMQDSQDSIWTVYALQEYSNKGTLAEFLDIVGTVPVEVLRSWTIQLLEALEFYHRSGFVHGNIHCGRILLFRTRTGGTIVKLRAGIEEALPDSPASKRLLTTSKSPFWMPPELTHGTAPLTMKTDVWDLGIVFLQMGFGTDVLQRYTSANALMGTLGLSTALQDLLHEFFRPDPKKRPTAFQLQPSEFFRVDTPLIARTSASNSISLPRRPRLDSLNGLPAFSRYNQDFDEAGRLGKGGFGQVVKARNKLDGRFYAVKKITQKSTAALKDTLSEIMLLSRLNHPYVVRYYTAWIEEDYDYVDEEAISSTESDVFASRDTHAYDYSTGGLDFISSSGYPKIEFGSDSDEDNDGTLSNGDKGDTPSTFETESATGKELSRVRSGSQGRPVLTTLFIQMEYCEKHTLRDLIRNGLYDDVDRSWRLFRQILDGLSHIHGHGIIHRDLKPDNIFIDVANNPRIGDFGLATSGQFTTAVRSSTTADFEGNFTRSLGTTYYVAPEMKSGIAGNYNEKVDMYSLGVIFFEMCHALSTGMERDQTLRAIREPNHTLPSTFQYTDKVVQGRIINSLLSHNPSERPTASDLLHSGKIPLQVEEETFRRAIMHLLSDPNSPDYKKILSGIFSQSPKKFEDIAWDMDSRGTPGATELLIQGLVKEKLTSIFRRHGAVETQRQMLFPRSQHYNNGAVRLLDSSGNLLQLPFDLTLPNARAIPRQDSSLEKTFAFGTVYRELPHGGEPRTHKEVDFDIVSHNTLDLALKEAEVIKVLDEIIEEFPPLRSSPMCFVINHSDLLQIIMEFCRITPSQIPRVKEVISKLNVGKWTMQKIRSELRSPAIGVASTSLDDLARFDFRDSPKQVQKRLRAIMQGTIFAERLAPIFARINLLVAYLQNFDVKRKVYMNPLGSLNDKFFRGSILFQCVFDSKRRDVFAAGGRYDSLVQEFRPKVLASRSQTHAVGFNLSWDRLSSAMLEYLGTPTKTPAKSFDMETGAFWKTRRCDVLVASFDPTVLRTMGIKIVQDLWLNDVSAELAVDASSLEELLNKYREDSHGWIVIAKQDSQERGFKVKSLSPREEFDIRGSELVPWLRNEIRARYQREGAADPLRQSRLPSQADPGPSFNERFSDVRILVPQHRSKKSNRRNIVETALFRSREVVEDALNGPVAAIDTRDELLEAIRNTRLSDPESWRTVIQNAPLTERKYLTQVHELLLDLATESRVDGMESFSNAFIYNYRTGSCIYYDLGSAADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZX3</accession>
    <name>A0A8G1QZX3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_479718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513152.1">
        <property type="nucleotide sequence ID" value="XM_025662965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZX3"/>
    <dbReference type="GeneID" id="37166367"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH55230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="111" mass="12562" checksum="9759904F47542F02" modified="2022-01-19" version="1">MLWEKPGGGEPAQTTWDLKEPLTVKWSHVSGEENKTFCIYLTNRVDYPPVTELVLRYAVMGRDEVTIPPPGPMDVPLNCNYRLWASACGDPETIYAETELFCIDVRDNADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R003</accession>
    <name>A0A8G1R003_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_424455</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
            <location evidence="2 12">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513661.1">
        <property type="nucleotide sequence ID" value="XM_025658044.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37161446"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 12" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 12" id="KW-0698">rRNA processing</keyword>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="587"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="BP28 C-terminal" evidence="13">
        <location>
            <begin position="1502"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="1761"/>
            <end position="1799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH55739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1800" mass="198862" checksum="8FB7E6CFC75C8A43" modified="2022-01-19" version="1">MASSLAAQLSQIAAKSTNQLNLKAQRIAHSQSLIFDWKTATTQDFDTVYQICFEGFQELCQLDPRFASFERTIFSEQSKAEDRTEMNAAQNKELDTVLEAFLALVGGHLLLSPAVKAVDWLIRRFRVHEYNTEFTILTFLPYYTTPLFLNLLSILPEDLTPTFKILNPYKKSQINPPRHPLVHSATTNKHFLAAVNRYTLQVSKQRAHHHALLSFWAGTLTEAVAGMLDSARSGRRELEKEKHEDVIMKVLPVLNDGLALKDVSELVIGCYMVCVVLAQKSSLQDKLLDGLMEAVAGSWTDETKESGLICLSVLAQKKPDARIPKRALKAVLRLEDPVQQLSAISAQYPTSHLLLGLVAGCVDDLSKQKDSSRLDLLSLLFETNLLGEQEAGQAIAIILQSVSRAHTEGVLSLDAQTHLAELVQHFTQSESLRPIFQKTIEESSIDVAALEHNLQTVIESVPTTTPAIEDVEMEDAQQEAVEDNFASVLESVAGKNLEASALSAQSMPAYESLVQTFALAVGSQDKLQAFVDLPGLKKADASTSPQYLSFFIRTFSGSYPIGTRITALNQISSLLTSASPDVDLQALLPFLLVALADSSERVRREAAGVLATIGSLYKKSKKGDANVWARDTIYGKQSKNVQWIAGRDVQKIIERAFLPGLEEYVLDQAHISRVLEATLRGSATSDSGATELKKPLRLSLFTFLCSHAVQMPLYAPKLSLLKLLNRVDKAGGTTRTKELGPFLKTWRDMKEQTAKDVCERERVSVADVDREAVLTVTPKDKDAITLLLSNVSPYSDSLRPSFVTAIFNRMKAVWGTVPEELQVDAAEKLFEISLEDVQTPLVHGCREVLRSVELTGSVLLQFLRKIPVSITDMESLGPAPKRRRTSQNNMVAMTIKDEAKLSQLMEKMTFILELVDSSTPEAHPELADGLFQTLAALHHFKAQIQSGLSYLLSLTLGSLLAIVNRSKGTAKAQFDTSVIRADLVVDCVRTTDSPQVQNAALLLVAGLSVIAPELVLHSVMPIFTFMGSSVLRKDDEYSVSVIDQTIDQVVPALIQSLRNQKRDVVSGTSELLLSFTAAFEHIPSHRRLRLFHALVTKLGTQEFLFAVLAMLANRYALDKDVLILMTGLVSDASAPVELSTYSKYLDLVKDSLSSKPGISQVLLGIGSDDGREPQKVAVDLLRALAYLFKHSSLKVKMAKDFATEEDKVVGQIRTLFSRILEQVLAIGESMQNVKPVSQASGDVLSALFGTLSLVDFLDTIEVLLQRRNDELRRKVLRLLEGRLRQNPERDGASQHRMLDFLPTLVNIVQSSPDILLKHAAVACIDRIAEKYGRKEPTKVIHAAQVVASEACIGQDDERIRIMGVLCLASMAEVLGEAMIPALPDALSRSLALLEQSLEDGKENARLHDAVFSFFSALFIHIPFMVSGSHLDKILVLSYKSAVSEGVEDESREEALQLMARKVDVAATFAAIDRNWQHAVRAGPDATRDTLGVVSLAIEKHQKSATVKNIAVLTSILFKAFDLRREQVSLDTQATFELSDVDEIEDIINEVTIKMIYKLNDTTFRPIFTKLLEWATTGVPKKDARGSLARLTTFYRFLQVFFATLQSIVTGYSSYILENVVSVLGKANPANQDTKSLWLATMRMLKNSFEHDQDEFWQSPSHLTVIAQPLISQLAHAKNSSTASIVIAEAVPALTELAVAADSTDNHKELNTVLMRLLRPSAGPSGKTAGGENPHTRLAALKAQQSLTEQLGEEWLALLPEMLPYISELMEDEDENVEREVRRWVKQIEDVLGERLDDMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R150</accession>
    <name>A0A8G1R150_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_449964</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Mediates the transfer of lipids between membranes at organelle contact sites. May play a role in mitochondrial lipid homeostasis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515164.1">
        <property type="nucleotide sequence ID" value="XM_025660279.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37163681"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017148">
        <property type="entry name" value="VPS13_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037235">
        <property type="entry name" value="VPS13_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="7">
        <location>
            <begin position="970"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="8">
        <location>
            <begin position="1831"/>
            <end position="2406"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="9">
        <location>
            <begin position="2927"/>
            <end position="3033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="720"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1246"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1428"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1597"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="723"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="755"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1272"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1431"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1447"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1601"/>
            <end position="1614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH57242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="3058" mass="344652" checksum="067E26D2C77E89DE" modified="2022-01-19" version="1">MEKIESAEMLKERNTEGMSQEEQRRNQSFTQSLVTAVVDNLQISIKNVHFRYEDSISSPDHPFALGVTLKELSAVSTDSEWNPTFIQSTSGTTHKLAILGALAIYWNTDANLLGTGRGSDIGAEAQGIGHAELIEKLRSGIDSEENVQFMLRPVSGRAGLEMDKSGGHDRAAIKARLLFDELSFVLDDHQYRDALMLVDLFHYFIRHQEYRKFQPKCRPKEDPRAWLRFAGEAVLSKIHERNRRWTWDYIKERRDDRIAYIDLFKKKKREETLTGADAENYERLQRKLSYEDIRFWRSLARNQLRKENVGVKKPAQQQSWSEWFWGSKKEESEETTMTEEQRQELYNAIDWDEKKAIADSVDVPRDWVKLQVNAGLRAGSFTLKRDPHGKANEIMQFVFDNFRAKALQRPDSFFIDLNLGGLRVYDGTTEGSLFPQIVKVKDSLPEPKNRLSQASDSQLEHDAGDDASDYRDGLFHLELEKNPLESDADSVVKVKMKSIEVIYNPRFIVEVVKFFEPPERHMESIGALLDTAGATVEGIRQQTRAGLEFALEEHKKVDAQFDIHAPLIIVPESITQESSLCLILDAGHISVNSELVDRQTMRDLQSKQKRQYEEGDYKELEHLLYDRFLIKLDSTQVLIGPGIETTKAQLSTDVQTRNLHIIDRINVDFVLEMCIVPKVTELTRTRISGHLPELHASMSDAKYKGLMKLIDIAIPNFDDGSAPSDTANKTKETTVSGNRARSSSFQPSILRELPNVDEDSDDESDDEQRKSVDKPTNIHRRDFEFKFTVGRLRGSLSRSDPKDPLRDQLLVELVAEGFALDYYMRPFDMVAEVVLKSLSVDDYIEENPVPEFKRILSSKGFDADEEKDLFHLKFVRVKPESPVFQSTYEGVAMNLDISVSTINLVVTRKTLLTLLDFVLLTFTNPEQPNNQITQSNETNQDISTVQEQPQQSGKIRIKADLKSIALILNNDGVRLATLSLNTADVGISLVDKTMLIQSRIGSLTLIDDVNTGASENSDLRRLLTIEGENFADFKYETFDPESTTYPGYDSEVFLRSGSMKINFLEEPYRKIINFLVKFGKMQAIFNAARQAAANQANQLQENASRMRFDVVIMTPILVFPGAIREDLPHDTVTAHLGEIYAKNTFVPLDENDKDGPAVNLISSGIRNIRLTSKFHYDEGTAEELEMIQKVNLEFSICYLEHQQDNPRPDMEVEGSLSPINLRISQKQLRFLLDLSKRVPNAFATDTEQQELEAMESLPSSVTDPTREAESRAVQTRQAQETTAPGASPNDETWVRLDMIFKVDSVGLELILSNDDAPVGCLEDASLSKFSLNDTRVKLRMLTDGSLESELLIHSLSIRDSRNKDTNKFRKIMSLINNDVKQQFMASVSMTPGPNNHLIAMLTIDSPRIILALDYLSALQSFANSAFATEEPVVEEDGDESPDESEPRTSTADSIEESTITPSSGGTAPAADRQMTVSFRVNLVDAQVITIANPAITHTEAIVLGTKQLLFSHQNVSTLQISKVGMFLCRMDKFETSRLRILDDFTLEVSVDSRPQEKGSSLTSINVHIEPLVLRLSLRDILMAIQIVNKASEMRAQGTQSIEHEEPKKLSDVKSTRPISSRRRSSGRQTSAAMVSRNERHSSATAENSGGELVSQRSAVLKREELNAQIDGIRVILIGDLHDLPLLDWSVKKFNVDIRDWSSTLHADTNFETFVNVYNFSKSAWEPLIEPWQLGFHVAKETAPEILSIDAYSHKTMELTVTSATIALASKSFQFLSTDEDVLSKPRGADAPYRIRNYTGFDLHVWADVSPDEEGPAAKLADGEEYPWRFEDSTAMRETLAPEGHAGLVGVKLEGSGFDSVSRIPVVREGEILYGLKPKKDGILHQLLVEVKLGPDNVKYITFRSPLVVENSTQIPVELGVFNPNDGHLLKIEKILPGDSRPAPVGAAYMHSLVIRPDQGFGYDWSREQLHWRELLRRPTRTIKCLSEGGQQAPPFYFQLHASFNARDKLTGVYPYMRLRIFAPVEIQNLLPYDFKYRIYDKNTKKDWTNFLRKGGVSPVHVVELSHLLLLSVDLEDTVFRQSDFAIINGNSQDYRREHVLSLKDDRGIQLRLKLHYFNVPDSGGAFKISVYSPYLILNKTGLPMEIQSKAFLQSARSAAGQGLMADSRHGGRSLPYMYSYHTDDQKNRSMLRIGESAWSKPQSFEAIGSTFEVVLPDRHGRSEIHSGVSVAEGDGKYKLTKVVTIAPRFILKNKLNEDILVREPGSSNVLQIKSGELTPLHFLRQVVDKQLCLCFPGVNNQWSSPFNIADIGTVHVKLAKANQRQRLIKVDIIMEGATLFIHFSFEPRNWPFSMRNESDMEFIFFQANPNLEDDEEDRSNGWRPIRYRLPPRSIMPYAWDYPATKNKSLVLTCKGKERHIKLAEIGNLIPMRIPPTQYGETQKIIDINIVANGPTQTLVLSNFKASKSIYKQKGQASQSSLSTGFEVKELDSDVNFKAQLRLGGIGISLINQNLKELLYLTFRDIEIKFRESRVYQTLNTTIKWIQIDNQLYGGIFPILLYPSVVPKTGKEMEAHPIFHAMATRVKDDSYGVLYIKYATVLLQQMTLELDEDFIAAMLDFVKVPGASWSEPHEGKLCDEDLNIPEPQNEGAAQDVYFELLHLQPMQIDISFMRTERVNAEDALQPSNPLMFFVHVMTMSMGNVNDAPVRLNALMLENARVSFGVLVGNVQRHYTQEFLRQVHVVLGSADFLGNPVGLFNTVSSGVADIFYEPYQGLVMTDRPQELGYGIAKGATSFVKKSVFGFSDSMAKLTGSMSKGLAAATLDKEFQDQRRMSKSRNRPKHALYGITAGGNAFATSLASGIGGLARHPLQGAEKEGIQGFFKGVGKGVLGLATKPAIGAFDLASNLAEGVRNTTTVFDAEGLDRVRLTRFIGTDGIVRPYSQREALGQFWLKTADDGKYFNEDYIAHLELPGRDMLVMLTYDRIILVRTKKLRTEWDMRLTDIQTISKERTGMSITLKGGANGPFIPVQDESSRNWLYRQIAIAVNAFNEKYNSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R151</accession>
    <name>A0A8G1R151_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_478943</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514529.1">
        <property type="nucleotide sequence ID" value="XM_025662923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R151"/>
    <dbReference type="GeneID" id="37166325"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF165">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="13">
        <location>
            <begin position="275"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH56607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="399" mass="41124" checksum="D5330376C5748149" modified="2022-01-19" version="1">MSSLPPVYIVSAARTPVGSFLGSLSSQTAPQLGSHAIKAALNKADGIKPSDVQEVFFGNVLSANVGQNPARQCALGAGLDESTVCTTVNKVCASGLKAVILGAQTIMTGNADIVVAGGTESMSNAPHYLPNLRNGAKYGHQSLVDGIMKDGLTDAGKQELMGLQAEECAQDHDFTREQQDEYAIRTYEKAQAAQKAGLFDEEIAPVELPGFRGKPGVTVAQDDEPKNLNPDKLRSIKPAFIPGSGTVTAPNSSPLNDGAAAVVLVSEAKVKELNLKPVAKILGWGDAAHQPSKFTTAPALAIPKALKHAGVAQDSIDAFEINEAFSVVALANMKLLNLPEEKVNLHGGAVAIGHPIGASGARILTTLLGVLKAKKGKLGCVGICNGGGGASAMIVESLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1H8</accession>
    <name>A0A8G1R1H8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleoporin NUP49/NSP49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_520379</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515591.1">
        <property type="nucleotide sequence ID" value="XM_025665131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1H8"/>
    <dbReference type="GeneID" id="37168533"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21121">
        <property type="entry name" value="Nup49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH57669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="478" mass="49201" checksum="4A8ABE41EBA4615F" modified="2022-01-19" version="1">MFGTKPAGTSTGLSINTGSANSLFGSGTNTQTSTTTTPATTTTSGGLFGNLGNTATQSKPAGGLFGNAGGATQQSQPAGSSLFPGLGGQQSNTTSTGGGLFGNSTATTSQPQTGGLFSGATTTTNNTQSGNTGGGLFGNLGGNTANQTQSKPLFGGLGGSTTTGGGLFGGSNQTSAQQQQQQSQKPTLSLFGNQNTTTQPTTQPAAAAGTTVIPGVKVDISNILPTTKYESCADEIKSELEKFDNFVLNQIKICNEVANMIPTIAGQGETIPHDVEFVQGKLETMQHALENDAGDIDQLRNLVSRDAAEAQVAFRAIDTLKLPLQYQSTGGAGWWSQDQKMSDGQALRSTRKNTLALPDDVESDPSTATSVNGVPVNLVDYFSQRSDEMGEVLERYTRNLKEIEDHLHGVEATLERQIHDFVTSRSRDGAAAGAPKSIVSELATVLGDVEAGILGVASRLGGVTEQVQEVVLGPPSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1S8</accession>
    <name>A0A8G1R1S8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoinositide phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_488536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514968.1">
        <property type="nucleotide sequence ID" value="XM_025663541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1S8"/>
    <dbReference type="GeneID" id="37166943"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="118"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="706" mass="79432" checksum="37432633A032FC08" modified="2022-01-19" version="1">MAASVLPFRDINLHAASSHYAFTSPSSPNAPTLVVERPTGDLRLSNGTLSGAKRISSIAGILGIIKLKLDKYIIVITKALPVGRLRGHMVYKVAATEFLPLRERSLHDYDEDTYLALLKELLRTGPMYFSYALDITNSFQRQSQTDPNLPMWKRADDRFFWNRFIQSDLIDFSLGEHDVTGVRYGPQPGVDPYILPVMFGMLRITPAKVKSTSFTFALITRRSRYRGGTRYFSRGIDDQGHVSNYNETEQIVILNDATGGLSGFSGGQSLAKDKLGGSAQDLQVMAFVQTRGSVPVYWAEVNNLKYTPKLQVRGVETAVDAARKHFAEQIRVYGENYLVNLVNQKGREERVKTAYEQLVRILVSSSTDSTEADEITSEKVHAVEPGLRQKELDRLHYVYFDFHNETKGLKWHRAELLLERLMDGLTRGGYFRGVENPGAPGGQLDTRSAQSSVVRTNCMDCLDRTNVVQSMLGRWAITRQLVDAGVLQPGEAANDDRDFENLFRNIWADNADVVSKAYSGTGALKTDFTRTGERTRAGMLQDLNNSITRYVRNNFMDGPRQDGFDVFLGTYLPPNSTLGNIQLFLDRRPLIIQSVPYIFAAGVFLITVAAFTRRLPDSTVWPLRLFVLFWFIVSAWCARFILAHGMLYVNWPKLNTPTAGSEGYQDALIKARSDPIVGQLFPARRHQRGYSNARLVFLEEGKTRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1W2</accession>
    <name>A0A8G1R1W2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_372718</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH56982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514904.1">
        <property type="nucleotide sequence ID" value="XM_025656052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1W2"/>
    <dbReference type="GeneID" id="37159454"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000003">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH56982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="105" mass="11962" checksum="1BA48DC77DA6D387" modified="2022-01-19" version="1">MAQERSGIVVGLNKGHKTTPLNTPKTRISRTKGQSSRRTAFVREIAREVVGLAPYERRIIELLRNTQDKRARKLAKKRLGTFGRGKRKVEDMQRVIAEARRTGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3D4</accession>
    <name>A0A8G1R3D4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_449750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514937.1">
        <property type="nucleotide sequence ID" value="XM_025660224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3D4"/>
    <dbReference type="GeneID" id="37163626"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH57015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="125" mass="13606" checksum="4E44740B4E5E75E6" modified="2022-01-19" version="1">MAAAIKAINAKIRSNKALDYFCSTHFWGPASNFGIPIAAVMDTQKDPEIISGQMTGALVVYSGTFMRYALAVSPKNYLLFACHAVNFSAQLTQGYRYLNYWNWGGREAQLAEAAKQGKDATEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3E2</accession>
    <name>A0A8G1R3E2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_519833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515853.1">
        <property type="nucleotide sequence ID" value="XM_025665081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3E2"/>
    <dbReference type="GeneID" id="37168483"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034899625" evidence="1">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="107" mass="11816" checksum="F567EDF5A09B4712" modified="2022-01-19" version="1">MKIASILLTAVFAAFAAAAPVASEDSHAVIPVNSCHHQRGSSPYVVALVDARRLFEQHCRYFQSYSNKLVLSSASLSFVLFEFCASVQVFPVNQVFLCFYVNAEAYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3G7</accession>
    <name>A0A8G1R3G7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_258218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516810.1">
        <property type="nucleotide sequence ID" value="XM_025655003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3G7"/>
    <dbReference type="GeneID" id="37158405"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="29494" checksum="3E4C6A9DD350E78D" modified="2022-01-19" version="1">MSRPRAVRDDLWIEEDAKVNVDYLAHSWTYDEMWATRKHVRQINQHSLVRCRFENALWRAWLASTRQTIRMPAAFISWDKDSDITWLYGPLKSSRSPSPTPSEAPPAQAPRKPSLKRKTSIWGLSEESSMSNDSTDGKSLLGRFWSITIHSVPSIILSSRENWNKRRKCRVRFEEEVQQCLYACDGNTVSQYSYNYNYPYFLEEARLYGSYQCQQTIEPLPSTFLTGYETLPPANSGQYYSMSNFLEELDEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3Z6</accession>
    <name>A0A8G1R3Z6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinamide riboside kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_450041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515237.1">
        <property type="nucleotide sequence ID" value="XM_025660289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3Z6"/>
    <dbReference type="GeneID" id="37163691"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32114" checksum="7E30E207E7D79212" modified="2022-01-19" version="1" fragment="single">IPLIPHPRNPTTSIQNWDTLSALDIPFLSAALCYIHSHGHLPPRLRSKEDLNDVSESGVSEEVVSRMREVVRERVPGYFLDTKVNSTSEDGDGDGDGVRTIVFLEGFLLFAPPKEEDPDHGLRDVQEKMDVRLFLPARYDNVKERREGRSGYVTIGPAPVHQGSEGESGDSGGGTELPQRGSVEVDVEKEDDRPPQNFWTDPPGYVDDIVWPNYVQDHAWLLLPERDEGSTEWRNADTQELVKLVGQGVNLRMDAGVTVAPGQGEASMTDILEWAVEEVLKHIAETEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R404</accession>
    <name>A0A8G1R404_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone deacetylase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_49569</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514347.1">
        <property type="nucleotide sequence ID" value="XM_025663943.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37167345"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="9">
        <location>
            <begin position="830"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="349"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="604"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1121"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1163"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1550"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="120"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="604"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="666"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1163"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1552"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1573"/>
            <end position="1584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH56425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1611" mass="181002" checksum="AFD2100795227B9D" modified="2022-01-19" version="1">MNSSGNDNWHPGGPPAHPGMDQMNQGPRPLGSFSQNPPPQQGPSSQPTGPVLPPPAGPYHPANQPGGHSLPGLAELSQGHAGPHQPPAYGQHPAAPGHNAGHSLPGIGQAMQHPSPQSINRERERDSRERELIERQRQEEMAHREREQREREQIERQQLERQREQQHHPVQSHTGSIPIHQPVASKVPNSIHGPNGLLSNLGSNPSNGPQGSMPTPGGPGGIYGPQMQHGEGTPRSYMQHPGGPPGQPMMGFNGSGPQIPGNVAALAQGQQPILNDALSYLDQVKVRFVDQPDVYNRFLDIMKDFKSQARIDTPGVIQRVSTLFNGHPALIQGFNTFLPPGYRIECGTEDNPDAIRVTTPSGTNTLSMPRARHSLDSSGELGPSGGMGPHGRAEYYDQSRPGWQQPQPQQQQQQGNLPGSYSPGSRMMGPGMFGQQGGQGQAQEHHFEYPTQQEQQAAAGAAAMAHQQDQRGVSQLQGAASAASAGLTRPSLLQVSAASQQGPSLTQPMNNLAGVGTGMLQGSQDLTKRGPVEFNHAISYVNKIKNRFASAPEIYKQFLEILQTYQRESKPIGDVYAQVTQLFNTAPDLLEDFKQFLPESAAHAKQQAAARQAEEAAPMSNVRGEPSYPNANALPSQTPNRDVKMPPLGQFNVKDSAKDGKKRRNGPGAPSSMGSSMSGPSAADAARMGDMQARNPALQAGNANKRAKVHHTKPSQAEVPAVSPTLVPALPEPIQPTFSLTPTQEEFAFFDRVKKYIGNKQTFSEFLKLCNLYSTDLIDRHVLVKRAASYIGSNPELMAWFKRFMHVDEPEDKIIDVKAKQDSGLVNLSHCRSLGPSYRLLPKRERQKPCSGRDQLCYSVLNDEWASHPTWASEDSGFVAHRKNQFEDALHRIEEDRHDYDHHIEACTRTIQLIEPIVQQFLVMSEAECAAFKLPPGLGGQSEAIYQRVIKKIYDRQRGEKIIKEMFERPTHVLPIVLFRLKQKCEEWKASQREWDKIWREQMQKAYWRSLDHQAIASKQVDKKLFVAKHIHTEIQNKFEESRNLRKSGYQTVKHQFEFTFDDPAVIIDATHLLLTFIDRNSAGFGADPQKVMTFIKDFVPVFFGMDRDTFHVYMNELSNGASPIDEGDDESLAAEESSTPRSRKGINGKKIDLLRDVLERRSEKVRRGDKEGSTPASRDGTPDAVLVPSTPIPDPTEPFDVAELKWMEHPGQGNFNQQREYNLNETYEKKTHHLYANLNIYCFFRTFEVLYSRLLRIKLHEKDAHDDVRRALVSKPAQELNLIDKYPTEFFYDCDPKANLYQQIVRMCEEVIKGDMEPSHLEETLRRYYLRSGYQLYNLEKMFAGISKFAGAIFNGDSKDRSSDIMNLFFKERDKEETTHNQEIQYRKQVERLVKDGDIYRITYNPTTKKTTLQLLTPEDATLENEELSQEARWSYYVSAYTMRDPTEGVPFSQMRMPFLKRNLPAKLEQEEEYNRYYRPLVHQDGLIIRICANSYHILYEPGSYDWWWRPTAPAEEAAEEVAKEEAAVKERRRDRFTEKFVNNPHWAHGLSKDQVDESNQRFRSWIKGSDGEAAAAAAPAEGTETESKNDKEDTEMADVEQSAVESKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R460</accession>
    <name>A0A8G1R460_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_421049</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515327.1">
        <property type="nucleotide sequence ID" value="XM_025657916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R460"/>
    <dbReference type="GeneID" id="37161318"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="41"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH57405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="348" mass="38134" checksum="3B36A2E083FB5416" modified="2022-01-19" version="1">MSSLTAAQIEAMEANPGATRAPGIIACASITMAASAAGVILRVIARSITSMRLGLDDYFIIVGLFFNVAFSVSIYITIHFGMGKHIVYVTDAKGLTLSITIAECFYCLAICFTKLSILTFYGRIFPQRWFRLMTWFMAFVVVAYNFCSVLATWLQCVPLSHAWDPSVSATCIDYYAVVVFSGVTNVVTDFIILSMPLSVIHQLHMSSRKKRMLASVFALGFGTCIASILRCIEAQALNSADSSWDLQGAIDCTSVEICVAMITACMPSMRPLVSKIFKSNATQANSKMDPTAGTYKMSTQKGTRSRADRGWSAIDHEETQRLPEERSADELSLGSLKQAYRADVRQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4M0</accession>
    <name>A0A8G1R4M0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_436916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517918.1">
        <property type="nucleotide sequence ID" value="XM_025658594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4M0"/>
    <dbReference type="GeneID" id="37161996"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="331" mass="36608" checksum="040E7BE740AE14CD" modified="2022-01-19" version="1">MAVSYEGMGLAAHQFSGQKLPLLQAAVEWFGVCEGVLEEVQGGWDGGSGVLMCEEDGDPFVEYHRRPDHDYDGEDGRKWDEEEEEMLFSGESDNSFDYTNTTISTYSEVSFFDDGGEGIEDGDERGLVPSPLKVRKVSGESVGGSSSLQGSEGENHAMGVAKAGVGVSLPLPLRIAAPTTSASIYTGPKKEVGIQMWQSVKTPAYKGELQTNTTIVFLRQQVTSSITTLHRMITDVAEMQYARRMSKGMRRSGSFWSFSPVKEKHVADGDDIGREKSSFGVKESTEQRIARLRRDGWQTVGIRGQRSGWKGEGYYREYCERVLDELYLGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4T7</accession>
    <name>A0A8G1R4T7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_437336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517205.1">
        <property type="nucleotide sequence ID" value="XM_025658616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4T7"/>
    <dbReference type="GeneID" id="37162018"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="762" mass="84032" checksum="ED996285028D97C2" modified="2022-01-19" version="1">MEAVGSASAIIGIATTGIQCSIKLLTFADQIKSAPDEIRNIAEDISVNASILQQLGGLADKELFQTQAATDTNTNNSISNGKARTVNPEAIDYSDTEGHEPQNGIFNAAGFAIVMNLASKCNAIFERLEEGLRKASKQLRANPQSKDPIRLSPAEMVKWPFVKPQMDSMRAELRDAKGTLMLLLQVAMLRYSKKVMEGHTTRTSLIAYSEEDQYLLKRSIVAAERARVDIAKQRDDTLAGNRTASVAERDTVDENLQPAEMTTTAAISLQLRRPPSLENGASRGIPQISSIEVKNLDCQPHRDIDFCSAHTKPSDAGKALAADGDIWNPSRTYPVHEGSGCDLDSLYYSSVYNNRSSIASISSATDALLGVYLLTPKLQIAHGKHHVEYRVRRVEVPRQDIDSQIDQWKKSSNSTVLNQLLALSADEQQALDALNLDGDHDNFTGTDAIEWIQVGEFLPVDGFDDIRTRSITFIVKLKHPSTTSKRRELKSEDLRDQQDIAMDFSVNRHSIFPESLNAFGLPWKWNVSDYNYMLVNKAMFNHFEGELLAHTRRLVNERSKMQRDSNRTELEVNGQKKSRRPGLLLHIRRVLRTIDPRHKINAPNPSSNRILGTAVAGAAVGEGMAAGGSIAVAGGLGGPALHGRRGRRYYGYGGWVKENVERTSQIQGSEEKNPPYPPEPVFSQSSSVPQALECRWHSCQSRPLADLVEALPRASRAPSDSLAVVESLPPLPSTTIHAVKPNEEEEDMEGIVGELLDRYTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R523</accession>
    <name>A0A8G1R523_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_460276</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514857.1">
        <property type="nucleotide sequence ID" value="XM_025661709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R523"/>
    <dbReference type="GeneID" id="37165111"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH56935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="173" mass="19791" checksum="BE8FADCB4D8CD8D9" modified="2022-01-19" version="1">MRTSPNVIITGTPGVGKTVHCEQLAEETGLRHLSINHVAKERDCYETYDHELQTWVVDEDKLLDAIEDQVLQGGYLIDWHACDLFPKSWIDLVVVLRCPSTAVHYDRLASRGYNETKLQENLDAEIFGVLLDEAREAFDEELVVELNSERDDDVESNCARISSWVQSWKNDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5D9</accession>
    <name>A0A8G1R5D9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AT DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_485979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517429.1">
        <property type="nucleotide sequence ID" value="XM_025663357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5D9"/>
    <dbReference type="GeneID" id="37166759"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="478" mass="54013" checksum="D3F7CD8056E54434" modified="2022-01-19" version="1">MSDSDTALLPWESVNDAFFGSHCDSTAPQITSLLSACSYPVPQQIRQQQRRQQDVQLPLLGGIIPENQLLLYNNDTQPTQPPEKTLKRTRNEVEKSGSAALTKRGRPRKVAQDTADEDPEERRRRQIRLAQRAYRSRKEANLSSLKGRISELEGIVEKMSTSVLSLSDELVRSGVLASHAGLTEHLRDTVQTCLTLAREASNDSPQEVTTISPPQTDDGLPDFLPHEQLSQSAQIVELDESVSSILEPNLHLELRESPITLSKKIPRFFESSETAEMDLTVFTDRLHMSCVYQGCFALCDESIGIDRIQKHFCLLLQIMERKRIASYFQAALNEKESRKYFAEWDEVPFFSLGGAGTHYSRSSLKSKAADRPFRPGVRWVSVRSVSHFPQHIQTKLQGDWFDMGDLEGYLREHDVHLLTYPPMDPTRHRLKGTAINAARFIQGMAPFRSLLFDSQYSLIGSTIRKCNMSWVDAGVQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5E9</accession>
    <name>A0A8G1R5E9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_252834</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517815.1">
        <property type="nucleotide sequence ID" value="XM_025654949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5E9"/>
    <dbReference type="GeneID" id="37158351"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="168"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="424"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH59893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="479" mass="53753" checksum="1CB8EF189043413F" modified="2022-01-19" version="1">MPSLGGLLKKRRTKDSQTLSKELEAGSAQTQTSPNAAEDHHNHNHHHHLFHHHHHQPQPATNSGSSTNPPSQPQNSVPQEQPNRSSGAEKSSDGQVASMQSAVTQASPSAHHTSGLPQPNANAASIQNIIHPSQQGAMHSASSGHAQSHHAARSDARTTKGKYSLDDFTLQRTLGTGSFGRVHLVQSKHNHRFYAVKVLKKAQVVKMKQIEHTNDERRMLNRVRHPFLITLWGTWQDSRNLYMVMDFVEGGELFSLLRKSQRFPNPVAKFYAAEVTLALEYLHTQNIIYRDLKPENLLLDRHGHLKITDFGFAKEVPDITWTLCGTPDYLAPEVVSSKGYNKSVDWWSLGILIFEMLCGFTPFWDSGSPVKIYENILRGRVKYPPYLHPDAVDLLSQLITADLTKRLGNLHGGSDDVKNHPWFAEVTWDRLARKDIDAPYVPPIRGGQGDASQYDRYPEETEQYGMAGEDPHGHLFPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5F1</accession>
    <name>A0A8G1R5F1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_246456</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517535.1">
        <property type="nucleotide sequence ID" value="XM_025654892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5F1"/>
    <dbReference type="GeneID" id="37158294"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="315"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="361"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="406"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH59613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="458" mass="49399" checksum="1E24C6DC5320E5D6" modified="2022-01-19" version="1">MADVGDRMFCHACGGVWLREAQGMICPHCESDFTEIIEIPPDPDAEPPPSFHRPPSPPAAANARSPNPWADHNPWAHQEEDDDLDHGWGPGHGNGFTHRTYRSPDGRFTFSTTTYTHGLRGGSPPTQQRQANPDPLMPMVQGLDSIFHGLASTYRQQNRPGGQAQASGTDRDRGRTLGSFAFDIEAEGRTGTQDGGLHPRDADGPQPVNNPLRTLGDILELFRSDFGTNTQAGGTGGVRVMTGPNPLAMLSTLLNFDRHGDAVYSQEELDRVISQLMEQNANRGAPPPAPPSAIQSLPKKKVDEEMLGSEGRAECSICMDTVELGTEVTVLPCSHWFHYSCIELWLNQHNTCPHCRRSIDAPQTEGASSPPGNRPAAEGTSGNPVVIPDSPERERTQPSAARDAASPSGWSSQSFSSWSSPWSGSEGPEQQQQRRSSRGEGSGGFTGWVRSRLGGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5Z2</accession>
    <name>A0A8G1R5Z2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_391549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518051.1">
        <property type="nucleotide sequence ID" value="XM_025656813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5Z2"/>
    <dbReference type="GeneID" id="37160215"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF11">
        <property type="entry name" value="SHIKIMATE O-HYDROXYCINNAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH60129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="58089" checksum="7A8F72A7A2201910" modified="2022-01-19" version="1">MSATMPTKQVQVISRHPLQCASETAVSVLESPFELGPLDHMVLPFVPVDAVFVYRKPISDANADDNALIEVGRLLRALALVLDYYPHLTGRLHFDPRSHRPKIVSLGLGAELLEARCSLRLDDIKSKSNRLLLTDLPDSGNALLPPFDSTIEGVCRDPILAIQHTRFACGSVALGIRIHHIACDACGFFQFARDLAQLYRALGPSGRGENVAGTPILSPPPEIRSYLRDPGSMTSEERESALQSNQSAYYLVDDPGTSSDTEPSTVANKPAPPPVLGRVLRFSSQKLQELKARATDPNGQDWISTNDALVAYLYQLTYRARLQHLIAQGVPETTAFNQLSTGIFSSIDMRGPTRLNLPPRYFPNCVYGAYMYLEPQTLAHGPLWRVAKAFHDMSHGVIPEQMKQNTQWLAIQPDKSRIRMNFDFNGSFTTSQWSKFDMYVGTDFDVDQHGNAIPPVVVSRPFTDISRVDGLAMVMASEVQVYRFMNTSPSSKGQCAVYVNYTLSEPVWAYLDQDVEFEELCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R670</accession>
    <name>A0A8G1R670_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_447801</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517864.1">
        <property type="nucleotide sequence ID" value="XM_025659788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R670"/>
    <dbReference type="GeneID" id="37163190"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.70:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="13">
        <location>
            <begin position="36"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="12">
        <location>
            <begin position="529"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="250"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH59942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="646" mass="72787" checksum="39F5F88DD37F3FCD" modified="2022-01-19" version="1">MTSASDLAVSVEGLSIQSTSETSKFPNCFPSLNPVDVYREHIAEELAKITGLDAEKIFSRIAWTNSLDKGDLVLPVPSLQIKKNPQELCKELVEKFPESDLILPPVAFGPHMQFFFRPERLTKNVVSRILKEKSAFGTNGNVGLRDPADPSKGRKRIIVEFSSPNIAKPFHAGHLRSTIIGGFLANLYTVMGWDVIKMNYLGDWGKQYGLLANGFKMFGSEEELTKDPINHLFNVYVKINGIVSEQEGPIKELKEQIKAKKEKGEDAAEQEKELAKLVDASEDENARRYFKSMEDGNQEALALWRRFRELSIEKYRQTYARLNIDFDVYSGESQIKQESMTAAYQTMEKAGVSEKSEGAVIVDFTKHGAKKLGKAIIVRKDGTPLYLTRDIGAILEREEAYKFDKMIYVVAAQQDLHLAQLFKITELMGYKDLASRCQHINFGMVRGMSTRKGTVKFLDDILQDVRDKMHEVMKKNTEKYEQVADPEGTADILGMSSVMVQDMTGKRINGYDFNLDAMTSFEGDTGPYLQYAHARLCSIVRKSGLNVDELDTANLSLLTETHATDLARLLAQWPDVLLNTNRTLEPTTILTYLFRMTHVLSSSYDVLKVVGSEPELKKARMALYESARQVLHNGMRILGLSPVNRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6C2</accession>
    <name>A0A8G1R6C2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_458038</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH60017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517939.1">
        <property type="nucleotide sequence ID" value="XM_025661558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6C2"/>
    <dbReference type="GeneID" id="37164960"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06421">
        <property type="entry name" value="CESA_CelA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF7">
        <property type="entry name" value="CELLULOSE SYNTHASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="584"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="8">
        <location>
            <begin position="182"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH60017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="602" mass="68351" checksum="3CBD1CA7994913B5" modified="2022-01-19" version="1">MEPAIRQLAQTYVGHVRRVSLSFCTLYMALRLSCLICAPETNYWMWVVLIFEALWTYQSLSIELPRRTGETSKRLHLTKNHALPSVDIMLPCCGEPIEIICDTIRAACVIDYPQTAFRVLILDDGNSLELRQAVEELQHTWPNLPYYSRGTKPSQKVFAKAGNLNFGLFDIQGGMDKPPELIAIFDSDFLPAPNFLRATLPHMLEDDNVGIVSSRQDYYNLPQGDPLDQSLAMFFEVILPKMDEMGSSLATTSGCLMRRDLAVQVGGFPTLNEVEDITLSFILPAYGKRVVYLTEMLQLGRVPTSLEGHVRQNRRWLTGLTEMIATPWTPSAESIPTPLRYSMAYFGIYWVLSPLGQSIGCAIIAPALISRQALVPHHLLQVQIPSSLVAFGLVSLYEWLKAAAMGFRLSVFTHFGELWLCADRICTLIQFHIFGSQGGRSLVTGSVQNTWNNPSRVPTRMTQLKRDLWDARVGFNVLFVFGVLAGIFHSVIGIVERYHHHHHPDWQLHLMTTLLYPPVVLMCYIILTCHLVPLSCVIWRPQYPPRKAVFDTHPSDPRAVFPSEAVRQSNVRQRHAPLGHRRHLLLIPVYITFMSVFYFRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6J8</accession>
    <name>A0A8G1R6J8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_446704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518044.1">
        <property type="nucleotide sequence ID" value="XM_025659559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6J8"/>
    <dbReference type="GeneID" id="37162961"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05238">
        <property type="entry name" value="Gne_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050005">
        <property type="entry name" value="DenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF043036">
        <property type="entry name" value="ErythonDh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH60122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="323" mass="35076" checksum="86B11635C2DFDC05" modified="2022-01-19" version="1">MSILITGASGYVGQELAAALLTTLPSSTVTLTDVVLPTIPKSAAQHASRAQCIEADLTNPSVVDSLITSTNRYDTIYLLHGIMSSGSEANFELGMRVNLDATRYILDRLRTVTPGVKVVFTSSLAVYGLAPPGYIINESNFPAVPSSSYGSQKLIIETLLNDYSRRGFLDGRAVRLPTVTVRAGKPTQAASSFASDIIREPFNGRPAVLPVAKETEMWICSPATVVRNLVKAREIPAENFGDSRSVNLPGLKVSIAEMLEALESIGGKERRELVEERYDADIDRIVQTWTPNFDTKRALELGFVGDVSMRENVEMYAKSLGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6K4</accession>
    <name>A0A8G1R6K4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nonribosomal peptide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_514535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515637.1">
        <property type="nucleotide sequence ID" value="XM_025664765.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37168167"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19531">
        <property type="entry name" value="LCL_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000084">
        <property type="entry name" value="Enniatin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="754"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="849"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2346"/>
            <end position="2420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH57715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2865" mass="317701" checksum="B428EB16C6CC8D33" modified="2022-01-19" version="1">MANQGEIGGNFPSLNDGVEAECTVRVQDVLTLPVTEIEKFCRDTGTAIPLFIKTVWLIVMWPFLEIDRICIGYRDYRDSPPHRASGPEKVIQSGILPDISVMKLLESDIGTESGNLCDECPPAHNTAIALIREISESDRSELLIEAEKWNYSIALVGEVDEVSALVRLSLVHKSSTLSPCLAENISSTVLQVIQEILADSHRRIMDLSLFSSSNRDHVLRWNRKDNRGPAVSLIEQVHQHACERPHHPVICAWDGVLSYSEFDSLTTRWASYLQGLGIGPQCMVPMMMTNSQWMTVAEIAIMKAGGTYVPLDSTQPFKRLEDIITQVNATFGISSPDLEPVLSSLVGVVVTLSATTTLRLPPVKADFKWPDITPDTKAYVLFTSGSTGRPKGCVVCHGALGNSKYHSQALRITAQSRVLQFASHGFAVSLLEVHCSLAVGATICIPSKEDRLNGLNSAMDSMRVSWAVLTPSAALSLATPLESLKTLALIGEPMRNDLFRKLADEVEVILVYGSTEWVGLCASHPIRSQIDIKCIGPSPTGNLWLVDPTDHNRLAPVGAVGEVLIESPGLAQGYLNNDSQTAANFVDAPAWLQMIGSGAYPGARFYKTTDLAQFYADGKIRYVGRKSTQVKIRGKRLDLGEIEYQIQQISPSIEKVIAEVASPKGSETPIVVAFLYSQDQEALLLHFHASVDAIKESLEKTLPDHMWPSIYVPLESVPLTRTGKTDRKALRHIISASSRQDLQNDQIPASPTVAPVTELEIKLHQLFAETMHIDPSSFGINHSVIQLGGDSITAMGLANRFRQMNYRLTMQDILEQQTVAKLASQLDGYNRNNASPTTSVGEEQFIKQSSQPASESVLCEDFINVLGINISSTDRFIDHLDSTTGAKFVDHVNRRLGINVTVQEVFQFPTIATLAKWLQSQCKGPSPISKTPYNGPVVQSFAQGRLWFLDQLHPGSTWYVLPFATRLRGQINLSALEAALNAIVERHEPLRTTFKGHDGIGVQVVHPFQPKGIKIIDMAISNNQNIWDALRKEQRTAFNLEVEAGWRPLVFRLRPDDHILSVVMHHIISDGWSLDLLQKELDIFYSAAIRGLPLFSQIDPLPTNYRDFSVWQRQQEDKDQSQVDYWVGELEGSKPAELLCDKPRPSILSGDAGLQTVDIRGALYRKLQLFCKAHRVTAYTVLLAAFRATQYRLTGAEDVTIGTPFAGRHHQELEPLIGFFVNLQCIRTKVEHADTTFYHLVRQIQKKSSMAFNNQDVPFEKLVSRLTEERDLSRNPLVQMVFAVHSQYDLGKLAIEGVEAQRVTLSSASRFDLECHFYQAEDSFRGEILFSLDLFYPETINMLHLAFIDILEHGLTRPTTPIDLMPFTDAKSSLEKNGLLEIHKTDYPRESSIVDVFQRRVRCCPSKVAVKDCSTQLTYHELDLESDRVALFLTDRSLAPETVIGVLADRGCEVIIAFLGILKANLVYLPLDVKYPVSRLETILSSTQSCELVLRGSHIEPPSMSLSNLHFISISDIFATMTQPEKPSPHAARTSMPRADSAAYVVYTSGSTGIPKGVIMPHKAIVRLTQCTSIISPDSAAGNIAHMSNLAFDMSVWEIYTALLNGGTLVCIDPMTVLDYRSLAQTFVRERIQVAMITPAMLKQCLIESPSIISQLDILFAAGDRLDPLDAMKARALVRRELINAYGPTENGVLSTTYSVTDKEVYPHRVPIGAPVSNSGAYVMDPRNQLVPVGIMGELVVTGDGLAKGYIDSRLDADRFVMLDLPGQPSMRAYRTGDLARYRPTDGQLEYLGRMDHQVKIRGHRVELDEIDQSMLAYGFIKHAVTIIRQEKAADSELVSFITLREGEDLHLAGDLEIQDGAQKVNAWEDLFDTSIYGLSRLRSSNLGRDFVGWKSMYTGELIENAEMNEWLDDTVGALLNGGSAGHVFEVGTGTGMILFNIIAGLESYTALEPSGTAVDFVQASVTTIPGLQGKVRLQKGIADNITQLDRSGSVDVAVINSVAQYFPSTDYLLKVIEDLVCLQGAKRIFLGDVRSYALYEEFQVSKALANSTPRLPTIDDIRSQMAETVHLEEELLIHPAFFTSLPSRFPKLIEHVEILPKRMVATNELSCYRYAAVLHTKHQQAQPRNIHDVEERQWLDFIAQKMNHASLLEYLQEQTNDTSVVAISNIPYRKTLLERLIVDLLRGRLAQRVGGPGWVESLNEMAKRIPSLSPLDLMRLGKQSGFHVEISWARQHTQRGGLDAIFHRIQPDRTGSRVLFRFPTDHYGRSVRQLSNNPLQQASNRDIGKWVRKTLEKTLPPYMVPRMVRVLEQIPVNSNGKVDRRALANMVTVSAFHNTMTARADPQDDVERALLARFTKVLGKDIGISESFFDHGGHSLTAIKLVNGINQDLHTSLTVGDIFECPTVTGLAAKIRARADLHEGVNFRNMTPDSAPFSLIGGSISSNVSRELVKMGLSATDVMDIVPATDVQSWMLAGWTPVSISFDIHGSINVGDLRTACLAVAQRHSILRTAFTKLEGKDVQVVLRATDIPFTHKPIAGGCSDETHSGPSPMFSKLPTKFELVSRSPRDHSFSIWLSHAQYDGYSLPLLFADMRSAYNDRLPSLPIAAPFADYIYGCARLRSPDSLGFWKNYLQGARLTTLPNTTLRGDETAADVKATVTGDLPTPLPGIPLSMLINAAYAFILADTINTPDITFMLGLNNRDLPITGVEGILGPCINRSLIRVQWQQGWTVRELCQSVHDNYTAISRYGFIELPDIIANCTDWPVGTEFGCGINHFPALSKPSFSFNDAEVSNFSMTGQVDMTNHLYVRSFVGEETWQLQVLTSSNMMNPEDASVLASRILDIGHKFSQYPETSLSSLVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7A8</accession>
    <name>A0A8G1R7A8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_255159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517893.1">
        <property type="nucleotide sequence ID" value="XM_025654969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7A8"/>
    <dbReference type="GeneID" id="37158371"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="159" mass="18614" checksum="437A4EF22667B866" modified="2022-01-19" version="1">MFLCPSLAEGYQLYQDVPNFPCLRSLLTSELPYQYHSREVLFPLGLFLFFFSNFHAYFCFGFFFLFFFPFFKLINFSFFLSPSSAAYPNILLSSPPPSPSHILHYPSIHRPFLFRFTTNFFVSNSSSLCWKLLPARLFDTLPSFLFVFSVPPYSFLSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7P7</accession>
    <name>A0A8G1R7P7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO85DRAFT_446725</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAM41 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518073.1">
        <property type="nucleotide sequence ID" value="XM_025659566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7P7"/>
    <dbReference type="GeneID" id="37162968"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028840">
        <property type="entry name" value="Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="46"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RAH60151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="512" mass="57721" checksum="7E7EB5DD0E42EEB6" modified="2022-01-19" version="1">MRQATTFLLNTNSGYVRLRSINPSLPRHARIPGSFRSFSVDPYSTSSSHGISSPSNRSSSPGVITSQSTSTDRGLLLPSSSASFSTSSQRSDPGDWDANPDLSISAFSELPSKDFGVNQHMVINQEFKEALRQILWQFRAPIRYAFAYGSGVFQQTGSAPGSSQCHPSAPAAIKNMQQGQGKMIDFIFGVSYSQHWHSLNLSQHRDHYSGLGSLGSYMVSQVQDRIGAGVYFNPYITVNGTLIKYGVVNLDTLCRDLSQWDTLYLAGRLQKPVKILRDHPKVRLANQMNLLSAVRVALLLLPAEFTEFQLYSTIASMSYMGDLRMALPAEDPRKVNNIVSSQMANFRRLYAPLIENLPNVTFNDKRCTEGDWIDDPEANVRLTQDMDPVKRGNMVRRLPDSFREKLYFQYQTRYQIPRVEFDQMMKESNNNDSDLVRRRQGGPFEQRIADDKNLTKEVQTTIAKTIRWPSTVQSAKGLLTSGVSRTWRYLREKQDKYKKSGKKAKTSDAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7T3</accession>
    <name>A0A8G1R7T3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_517034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518704.1">
        <property type="nucleotide sequence ID" value="XM_025664882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7T3"/>
    <dbReference type="GeneID" id="37168284"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF668">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="26"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH60782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="376" mass="40538" checksum="4B89A143ABDF19E8" modified="2022-01-19" version="1">MSQPHSNCEGEDLVGDETGLEVKYKTLTWWQAGMLMIAETISLGILALPKVLATLDLFPGIAVIIGVGVLTTYTGLVIGEFKRRYAQAHSMADAGSILWGRTGFEILGAAQLIFFTFIMASHILTFSIMVSVLTGYSGCIVIFSVAGGLLSIVFTIPRRLESLSFLSSISFASVLGVVLVSMVGASKTSPIQTSLPPTFHDIMVAIANAVFAYAGYVAFFAFFSELRDVKDYPRALALLQVSEMTLYTVTAIVLYVLGGRDIASPSLNSVSPLFQEDSIWYRNPNGQIVIAGVVNAHVAVKSIYLRIFHGRNAMHSRSFGAISLGRCMRDAMVFGLGSSGKHTGFQRYLGAYGKFLGQMGNTLMYLGGLSVGNRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7U8</accession>
    <name>A0A8G1R7U8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_221789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518148.1">
        <property type="nucleotide sequence ID" value="XM_025654706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7U8"/>
    <dbReference type="GeneID" id="37158108"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="184" mass="19842" checksum="BD31760F55AFC93E" modified="2022-01-19" version="1">MTLGFKEEKTGENKGDEKKKIHLEREDESGAGDRGRKTRKQQIRACVRHAAGTSFCSSLAPPSYSLQCVRTTQDTQCTRPRCFPRPVSATNDPPDRVEKWIMPASADAHAPITAANTGFLTGAVSSRDSTGSMSSFAPPSVTVSDHLSRDADLVQCLPRILARPNQGIQPFCPQLSSLGLVGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R817</accession>
    <name>A0A8G1R817_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_367453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517861.1">
        <property type="nucleotide sequence ID" value="XM_025655816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R817"/>
    <dbReference type="GeneID" id="37159218"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="245" mass="27602" checksum="18EFA09EA755FD2E" modified="2022-01-19" version="1">MASEEPPAFNLTEVDRQVLAQTDEEFVLHDWEDLKSIIARNDLGILKRKPSDLTRYLSWSHKTKQQYGSITNYICQKRLGWTATIPSSPSSSSTTTTPSTSTPTSSITTSTETSTTTSSFPYKNPIPFADPSDYKILRNDWPYGLAPGISHIVVWLRTPVAVKEENGDVTDESRALIEAFVQRTFVDAVVRDEGVSEAEARDRVLWFKNWAALQSVRSLEHVHVLVRDVSERLLVEWTGEEGVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R843</accession>
    <name>A0A8G1R843_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_414766</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519240.1">
        <property type="nucleotide sequence ID" value="XM_025657658.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37161060"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="383"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="8">
        <location>
            <begin position="1298"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1669"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1298"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1460"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1612"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1623"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="4">
        <location>
            <position position="1330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="4">
        <location>
            <position position="1517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH61318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1745" mass="192235" checksum="559DF5B2414BB660" modified="2022-01-19" version="1">MRVVFFSNKFPGVDLRDLSQRLRFVSRSRSHGLLRRFLEEATMVANEEIRRLPPELKTLIPPFHSILDLVDSFDWHGGPLTGVFECAFTCLFHISLFLGSYERNPQEFNFSNSTFTGLGLGLLAATGIVASQTLLDVPQTSAEAVRIAMRTGYLLYQKQQEIEPQEPDAPPKSWSVILKNMDQATVQETLDHFNASIDVSITGKLYISVVEPDGSLFVNGPPSILAKIFGKTGKLASARHAALPVYGGPCHAAHLYDRADSARIAETVSPQIANRRVPSNVCLLSMVDGKPLGSQTVLELFESAIYCLLTGTIQWGNVAEAIFSSSDWNEEAHVHLESIFQPCPVVNTLISRAQATYPHCTVDTREHMQWVFMDENKPTNPSSTDIAVVGMSCRLPGGANDLTQFWELLVDGRDVHKKIPADRYDVETHTDTTGKRQNTSHTPFGCFIDDPGLFDNGFFGMSPREAGQTDPAHRLALLTAYEALEQSGFVPNRTPSTMATRVGTYYGHCSDDYREANAGQDIDTYFIPGNYRAFAPGRISYFFKFSGPSYSIDTACSASLAAIQIACSALIREETDTVVAGGLNLLTGSDSFAGLSRGYFLSKTGSCKVFDDGADGYCRADGIVSIVMKRLADAQNDNDNILGIIRASATNHAGNASSITHPHAPTQEHLFSQILKEANVNALDVDVIEMHGTGTQAGDTTEMESVTNVFCPGLKRRLHPLYVSSVKANVGHGEAAAGITALVKALLMFQKGAIPKHVGIKTAINKQFRDLGTLNVKIPMETVSWAHDNNRRRFALVNNFSAAGGSTCLLLQEPPVRSTPQACPHPTLPVAVSAKSKVSLKNNIRSLITYLQQNPSSDLPSLSYTTTARRMHYRYRVVVNGGSTQELIRRLQTCLNDVEMRRPIPKRPSVAFVFSGQGSFYTSIGRQLFEEYPPYREKIQRLDKLCLLHGFPSIIPLILSQEQDTAAVVPLMTQLLTTCVQIALTDLWRMLGVKPDVVIGASLGEYAALHAASVLSASDAIFLVGRRALLLQELCTIGTHGMVTVRASVDEICECFPHRKEYEVACINAQRNVTIAGPVEHMDDIQASLESNGYSTTKLNVPFAFHSAHVEPILRRFGEISRTVTFHSPKASVLSPLLADNVTSRDILADSYLERATRAPVRFASALERAQEMGIIHSNTAFIEIGVHQTYSNAVRATVRDMTCMVPSMRSDQSNWSTFAASMSALHEVGVEIDWNEWYRPFEPNLRLLALPSYQWDLKKHWIQYNGSWLLLKDKGLRTQDGGALAPVTPAFQTPLLHQILEESSSENGHTVLMQSNIMEDQLLKIISGHKMCGRPVMSVFAYPDMALSLANYIYTKHQPQVELPSMDFGNVQIFQGLVARKSQANPQWLRVRADADLKHRSVRMSFEHALEDGHGSHEILATGVVTCGDSQIWSDEWGTQTDLLISRIEVLYRLAQEGQASRLSGNLVYSFFKTLVDYSEKYRGIQSVVLHHLEGVAEVLLPPGEGGWTAAPNYIDSVSHVAGFILNGSNALDDHDTVYVMDGWKSMRFSQPLVPGARYQSYTSLKPAKEKPGFYISDVFVIRDGQIVGQIRGMTMRPLPRILLRRFFDPPEESPMSHKDLSVSSTISDSLTRTQSPISVSPGRPIDSIERDTPPSTPDDAEISPVARNDSGLVKQAMGIIASETSICPEELTDDVEFANIGVDSLLSLVLVEKFALGLHLNLRASVFQDCPSVGSFKEHLVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8C6</accession>
    <name>A0A8G1R8C6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_219893</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518026.1">
        <property type="nucleotide sequence ID" value="XM_025654681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8C6"/>
    <dbReference type="GeneID" id="37158083"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000095">
        <property type="entry name" value="C6 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH60104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="740" mass="82541" checksum="55F7B21CDAF779DF" modified="2022-01-19" version="1">MEQDDQSPPVEGTPTSRAKARSDHLMKRVSRACLHCRQRKSKCDLDSSGSPGVPPCQRCIRDNRECVLGSSNRGGRRIRKNKIKNFTPDSNSSVRRDSVIEAPSPSNSETRQTTSCSYPGPVVFLPPDPPTATSISVDDDEDEASIGDVPRNPSDAWQCLTGIAKRGTEDPSTETGVEPLRTGPSAFSSYTALQDSSVTGFQSNSGIKAYRLVQSRSLDPGTVWQLVVRYAENFHPYLPLVPRKYFDRSALDAFANNEKHLLTAVLTIASKDLAERPEIHEYCSKYMHELISGIAAGADCDVEAVEALLILAEWEPQGLRPRIERVGRGEEDRAAWMHVGLALRSGWFLGLDRTSFRGDSSGDAETEARRRLAWTSCYVSDRLISVRIGRAFWSRGPGPMTGLVSQDFPSLQPARDGDEDYAKIFQATLDLTQLYGNVHDVLYSGMRTSNQMMLMGDYVKYVDDFRLAILRWKSIWGSLSCSPPMKATLQLSYEYLRLYTNAFAFQAAISQSLVSKIRNDDKAQRDHLRATFNNVASMQDARFIYESVDAAKTYLTILVDVVHPEKHLHFMPLRYYLYGIYAAVFLYKARSFGVMSHLEELKVRDLVTRTTEVLKRASAGSDDIGSRYSRLLELLWKQKSMAPTSPAGTHQSGDVLMQSNSALSHHLSDQSSYVHFSPANDFSWLDLEAVGDYVSGDQISGANTLALDTFQNPDIFQAGQERSQAWQVPWSGDMSSSLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8F1</accession>
    <name>A0A8G1R8F1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_485294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518056.1">
        <property type="nucleotide sequence ID" value="XM_025663318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8F1"/>
    <dbReference type="GeneID" id="37166720"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH60134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="106" mass="11840" checksum="FFDE8ED6635760BC" modified="2022-01-19" version="1">MPTSQGTFRWTAPNLADAEFNVDGTFSRCDITLNVPIPNFGKTSATLNYDDISQLSGTQFFDGHIGRVDFETDFKNAPKIQGNLDTPIDKYIPVNGKGRWVEFFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8J8</accession>
    <name>A0A8G1R8J8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_251464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517772.1">
        <property type="nucleotide sequence ID" value="XM_025654937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8J8"/>
    <dbReference type="GeneID" id="37158339"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="76" mass="8410" checksum="F266825D70F0DF36" modified="2022-01-19" version="1">MSPALLDAESIYFTSYPSGEMVLRHCSKAEAAFVPHCWWDRQWVLAVSSLIVSVTSGIIVSARDKVIDTVSNFCCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9I5</accession>
    <name>A0A8G1R9I5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_182496</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="RAH60957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025654357.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="37157759"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001067">
        <property type="entry name" value="C2H2 transcription factor (Egr2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF34">
        <property type="entry name" value="ZINC FINGER PROTEIN 672-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH60957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="281" mass="30767" checksum="320F3CFE52E1A45B" modified="2022-01-19" version="1">MASCKASFVSILNNDDNPAFTVRSAPGLSRHQATSPYPYHYAPQQSIPAPEFRYHHAYVNSPSVSPGLARLPFDPVPEPVQPTSPGSSDCSYDYMSSTSVRSHYHLGRQDTNSYRTISEKRISGSSVTEPPSPQPSIGSTKESMAAKSGVRKNKYPCPFAASHGCSATFTTSGHAARHGKKHTGEKSVHCPICNKAFTRKDNMKQHIRTHRTHSEDMPTAMTTDRDSDGSSSWSTRRSNTSVYDHQRSISGTQMDASSYDSGSKLNPISTSRAYEPMSSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9Z9</accession>
    <name>A0A8G1R9Z9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PR-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_189756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519119.1">
        <property type="nucleotide sequence ID" value="XM_025654423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9Z9"/>
    <dbReference type="GeneID" id="37157825"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000018">
        <property type="entry name" value="SCP-like extracellular protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034223747" evidence="1">
        <location>
            <begin position="18"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="174"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="337" mass="34309" checksum="495E854141F3FEAC" modified="2022-01-19" version="1">MRYSLALGALCAAGALANNVDKRSYVTDWTVVTLTTTITEYPTPTVYENVAAQEATAAASSSAAAAAAAAESSSSAAAAAAAASASAEASSSAAAAAAAAAEASTSSVVTPVVETTAAATTAAAVATSAAEEVATSWTSAWTSAWTSSWSSTVAPSTTLATSTSSSASSTATNAYQSAVLYNHNVHRSNHSASSVEWSSDLESSAYTLAAKCVYEHDTSIDGGGYGQNIGYGVEASEIGVMITNLMYNDEMGYYTDLYGEADPDMTYFDNWGHFSQIVWAATTHVGCATVTCDSLGNVDASEALPFTVCNYSPAGNYEGEYATNVKRPLGQAVYVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA99</accession>
    <name>A0A8G1RA99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nitrogen regulatory protein areA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_246744</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Major nitrogen regulatory protein. Positively acting regulatory gene of nitrogen metabolite repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517542.1">
        <property type="nucleotide sequence ID" value="XM_025654896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA99"/>
    <dbReference type="GeneID" id="37158298"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056998">
        <property type="entry name" value="Asd-4/GZF3_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF338">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25026">
        <property type="entry name" value="Asd-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 12" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="17"/>
            <end position="64"/>
        </location>
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            <begin position="59"/>
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        </location>
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            <begin position="157"/>
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        </location>
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            <begin position="268"/>
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        </location>
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        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
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            <end position="183"/>
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            <end position="316"/>
        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RAH59620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="316" mass="34530" checksum="2A8DA673BF5BB083" modified="2022-01-19" version="1">MATTLADHKRPQLQPVCQNCGTSTTPLWRRDELGSVLCNACGLFLKLHGRPRPISLKTDVIKSRNRVKTAGQGPKRKSGGAIDTNGLSTSRSEAGTPPMGSQGYRRASRKASPGHSDRSNSPVSRTETPGIPSMQQPHPQSQHNANIAPQHMFDSVTIGDHGLSQPNALPSVQPRQPSPTATSAAVDRHLESPQTYDGLLAANTSLKTRVSELEFINELFRGRVTELEQSGATARRSEMIVRDSEVRLRRSLEEAQRREDDLKRRISELERQLSEQTSSANPAGNDSPGEPLAKRMRLSDVVEQLAESPTKSPKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAL2</accession>
    <name>A0A8G1RAL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_473374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="RAH62668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520590.1">
        <property type="nucleotide sequence ID" value="XM_025662620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAL2"/>
    <dbReference type="GeneID" id="37166022"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054293">
        <property type="entry name" value="DUF7029"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055647">
        <property type="entry name" value="DUF7223"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22974">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034087850" evidence="2">
        <location>
            <begin position="25"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7029" evidence="3">
        <location>
            <begin position="84"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7223" evidence="4">
        <location>
            <begin position="218"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="621"/>
        </location>
    </feature>
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        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="607"/>
        </location>
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        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH62668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="621" mass="65811" checksum="0C4FCA9366A37698" modified="2022-01-19" version="1">MVYPLHNGVATGLLASFLIQQGLALELTAFNPSTTTNTQVKVAAAGAEVQTQDYSSIDLRTSHSFYWGASTSGGSTLGNLTLVDESILPMESFSDMLENIQCTNSSITLGFSDSDAFTYAKNSWTWVNKAANNTFLMVAGVQQCSWNTQRVPFVITAANFQDNSTVRLAGKSATWDDVLRNHEITIGKAPSDMAVELTKRGITDGTKSGSISIDKTASDKSVKIFSKDDLTLSAECKSCGTSGEFDVEFKYKVKPSGSGFLSEIGNAFTGDWDVETAELTLTPKDVELDITPALDLSGNLTRSYSDEAQIAALTLEGIKIPEVFTLDVQLAFDIGASAGPVNGDASISYPMKISLDNDAEAVLDIANKKVTHKDWTPTIKTDGVKLDAEIDATLEAYVKASLELVLSVGKKWGYEAGIYLKPFLAVDFTAEASTSGTCSDTSKNYHYAIEVEPYAGIELGAEVAKVSDEGNPIADATLASFTQSMSSTCIGFDSITSTKTATSTKTKSTDESSSDDETSTKSKSKSKSKSSTKSSSKSASKSASKTKSHPNSASASATPTGHSSTHKHTSSSTKSSETSKSTITSYPKTTSAKATSSHAAASSSAHSVHNHGRSFRQHGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAP4</accession>
    <name>A0A8G1RAP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_134321</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520325.1">
        <property type="nucleotide sequence ID" value="XM_025654022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAP4"/>
    <dbReference type="GeneID" id="37157424"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000240">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000011">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF24">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="7">
        <location>
            <begin position="69"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="8">
        <location>
            <begin position="261"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH62403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="549" mass="60510" checksum="12765D5C48537A22" modified="2022-01-19" version="1">MSAPLVKVLHRMQELFTNIVAALEAMLLFPSLFRDPSRKRRKPFHGAYWGRRSLDAFADEVDRLFTAPLSVQNMVAMSDKIRAQFKSCLQSSPVCMLPSYNHALPSGTETGTFLALDVGGSTLRVALVELRGQGDMRILHVSSSYIDEDVKLLEGTLFFDWMAEKIDSMLREVGTNYGREAVPLSMGLSWSFPIEQTSNSSGLVIHMGKGFHCSNGTVGQELGDLIVQSCRKRDLNVQVDGIVNDSSATLLSRAYIEPKTRMSLILGTGTNVAIHFPVHEIGLTKFGARPPGWFDYAKHVIVNSEMSMFGGSILPKTRWDEVLNRTHLRPDYQPLEYMITGRYLGEIIRLIIVEAVESAKLFGGELPHSMRDAYSFDTSIVAALEADTTPLLSSSAALLQKEHTFTVSPSVEDLRFLRRVCQVVSKRAAGYLATAIHSMWCLRNEAEFPASAPSAPPSIKETQEVTVVESEENHRSLSIACDGSVINKYPGFRDRCQGYLNDLVKETNASRPSSDTTTEPQVCLDLAPESAILGAAVAVAVAVTEKKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAX0</accession>
    <name>A0A8G1RAX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GTPase activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_133094</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520279.1">
        <property type="nucleotide sequence ID" value="XM_025654004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAX0"/>
    <dbReference type="GeneID" id="37157406"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF125">
        <property type="entry name" value="GTPASE ACTIVATOR (BEM2), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="381"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH62357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="669" mass="75168" checksum="D0323489E545A478" modified="2022-01-19" version="1">MPSRQSTVPNLDLSTSTLQADAKISSPLTPGAQSSEGPSPLTPRSPKSSSSSPFFKGATIRPVTQESNSKSSSPTFPATSPGIAPAEPATPGITAIPQYPPSPKDTPKHTRDQSRSFFANLKAPKSSHRAQRSDSSGNSGEKPKSRGSSRDRKTQISTKLYESTPDLPGAIERAAQEENRGDRAEEKCPQPAEVKKVGTESDAFNLAKKNKPRFANLLSRSRSIRLDDSSMNRIAHRRPSTSLMRLEENTRKEVQEPPKTAPRHERNIRTAGNPTARSYPADRPAEYHNGHMRKDKYYAGSMVPSASLSQVSGASAALFNNLKQQSSGAADRIGKAGKGFFGKITRSGSTNERELVNDDNYVCSVINLPLIQQARRTRIAKRLEDCRDKTEFWMPALPYRCVDYLNFKGCEEEGLYRVPGSGKEVKHWQRRFDTELDINLFDVPDLYDINTIGSMFKAWLRELPDELFPKETQALIAEKCEGATTAPQMLKDELSKLPPYNYYLLFAITCHLNLLHSYVDQNKMDYRNLCICFQPCMKIDAFCFHFLVCDWKNCWQGCWTEKEYLQIEKEMDEKEKAAQEKDEAVHDCQQAQQPQQIQQFQQHQQPHQAHESHERAVSSGSSQPGQEEEPPRPEVPKNRKQRPKNIETSHTRSISQLPELGPPLSPIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGZ0</accession>
    <name>A0A8G1VGZ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aureobasidin A1 biosynthesis complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_482124</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510022.1">
        <property type="nucleotide sequence ID" value="XM_025663089.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37166491"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1211"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="722"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH52100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1838" mass="203731" checksum="B61F7A8CFB87A42A" modified="2022-01-19" version="1">MTETEQRQLAYWKEQLEGSQPAELLCDKPRSAISSGKAQVHHFTLNDQLYRELQTFCQTHQSTPFVVLLAAFRATHYRLTGVDDATIGTPILSNTNILCIRTTIEPEDSFYALVQRVQQTTSTASTHQDVAFQKIVSELCPGAADRSRNPLVQTIFAVHSSEDANSPQLDSMKAATSKYDIEFHLVQKAQRMSGHIIFSDDLFEASSIRLVESVFSEVLGRGVKTPEALVSTMPLTQGLSALADMGLTDVARTDYPRDSSVVELFRRQVSLSPNAVAVKNADSSSQLTYAELDRQSDRLAHWLVQRGLAPETMVAVLAPRSCETIMALLAILKANLAYLPLDVNVPVGRLESILSAVEGDKLVLLGAGVAPPALQLKDVSFRHIAQALDEQGQHFAGALPNPTASSLAYVMFTSGSTGKPKGVQVEHRGIVRLVRETNVASKTQSSGNIAHVANLAFDAATWEIYAALLNGGTIVCIDYMTVIDPVTLGQVLQREAVRSCMLTPALLKQCLANAPYALSGLELLFAAGDRLDPRDAAQAKSIIKGDLVNAYGPTENTTFSTIYKVPANEKCVNGMPIGVTISNSGAFIMDPEQRLVPPGVMGELIVTGDGLARGYTDSRLNKNRFVQVVINGESVRAYRTGDRVRHRPSDGMIEFFGRMDFQVKIRGHRVELPEIEHALLRNESVSDAVTLVHQPEGEPADLVSFVTVQGNIADAAAQEDPQNQKDAGDNSRLENQVETWRDLFETGTYADINRIDTTKVGRDFMGWTSMYDGKLIDTAEMNEWLDDTIHHMYRNGGHPRNVLEIGTGTGMILFNLIDNLNSYVGLDPSASAAAFVNKVAQARPSLAGKVDVRVGTAIDVNSLGELNHPDMVVVNSVAQYFPTQEYISSVVDKLLAIDGVERIYFGDMRSWAVYREFCTTRALHQLGSSATKEAVRHELTKAEAEEEEFLADPAFFTNLMSRLPEIVEHVEILPKRMKATNELSCYRFAAVIHKRQDGKPKAIREISEGAWVDFKAKQLDRAGLLALLQASSTASTVAVSNVPYSKTILERHIVDSLDDKTEGGADWLTSQREAANRCPALSALDLAELAEQAGFKVELSWARQRSLRGGLDAVFHRVEGLRPLFRFPTEHEGRSKDSLTNSPLRRQEAEVVEALLKKALQASLPKYMIPARIAVLDKMPINANGKVDRKELARLASVFGKATKTSRQIVEPRTDLERVVCEELSSVLNVDAVGITDNFFDLGGHSLMAPRIAARINQRLNATILLRDVFAYPVVADLAKRIGELVGDSSQDKLDQDSGEDEDIEIEDEEELLTMSLATKLRHFNSIARPQCVKSLGIASEDIEEVLPATGVQTRMLVFVEEAEEMNITKPCIEHFVYHVPDELDPARLEQAIVDVTKRHDAFRTVWVQVDHPLSPYAQCILNPAHPRAQLPMVQSVVHEYDTSPDSLWEQTIGNAQRSAEEYIRLDRPGAVVHVVHSADNKHHVIIFSLFHLIYDGMSLDFLRRSFAQAYEGVPPSNLPAVGMRLPVEKHYSTDWLATSMYWMQRLAGVAPFKAGQTVLKGVVPGQFTSIRTTQDTACEILESSISLNELFSLCKIAKFPSPMAIVQGAWAMTLAQSLVKADSADQEPSTANLDVQFGSVFHGRHSPEALRCVALMLDVLPTRIVFSDAYKSEADGGPKKRTHRQICQELFTQYVESLEYSEMPCPTIDFAKLTRRFDNTIILQAYPKEEVDVDASGLPKTNMETLPGFTREENLQAPWKETNHGYPILMELWPGRDNEDEKFRLRCTYNNRWPGYEFMTQEWAQGLLVTLNHSLDQILHNPDGVFDPVRLVEERQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHC5</accession>
    <name>A0A8G1VHC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein rho2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_453299</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511131.1">
        <property type="nucleotide sequence ID" value="XM_025661020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHC5"/>
    <dbReference type="GeneID" id="37164422"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000573">
        <property type="entry name" value="RHO family GTPase Rho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH53209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="199" mass="22194" checksum="A4E2FB8E05C9629A" modified="2022-01-19" version="1">MAQQQTDNVMRRKLVIIGDGACGKTSLLSVFTLGYFPTHYVPTVFENYVTDCRVDGRSVQLALWDTAGQEDYERLRPLAYSKAHVILIGFSVDTPDSLENVKHKWIEEANERCPGVPIILVGLKKDLREDPLAVEEMRKKSLKFVTSKEGSDISTQIGARKYLECSSLTGEGVDDVFEAATRAALLTFDKRKSSCCIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHI8</accession>
    <name>A0A8G1VHI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="13">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_463102</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="13"/>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511328.1">
        <property type="nucleotide sequence ID" value="XM_025661898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHI8"/>
    <dbReference type="GeneID" id="37165300"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="619"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="16">
        <location>
            <begin position="220"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="15">
        <location>
            <begin position="572"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="752"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="897"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="938"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH53406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="951" mass="106759" checksum="272F9F3EC3EDF00B" modified="2022-01-19" version="1">MAVIATTRLPMSKLILTSITFRPQAILTSTHILTSPRQPIRNFTTVNNLSVPTKHMQLSNQYANGSPPPNWMHQPTHYSPTPEDIEPSVAPTARRNRNRKKGFFQKKIPWVTYAFTLVQIIVFIVELVKNAQFTGSPIETKPSFNVMIGPSSYMQIYMGSRYTPCMKNVPGIQNANETILFSCPNATTSATECTLSEACGFNGVPNPHPHGSLDDNPAPNQWFRFIIPMFIHTGFIHIGFNLIVQLTMGVDMERMIGWWRYFLVYVASGIWGFVLGGNYAGQGEASCGCSGALFGILALFILDLLYTWKDRASPWVELIIMILGIAVSFVLGLLPGLDNFAHIGGFIMGLALGLCLLRSPNALRERIGLARNPYVAMSGGAGTPTPDDNQKVNTGPSLVDFLKGRRTRTGAGASNNKWNPVNFFRGRKPLWWAWWLVRAGALVAVLVGFILLIVDFYKYPKSNCSWCYRLSCLVSACDRQTVAVRYGTCNPNNMGCLGRGQCRLQATYELGIPSSFLGIILYICLNACYTVAVFTDPGSPLTPSGRGRHEYSALPVTELPQYTAYTVSSTGGSRFCKKCQCPKPDRAHHCSTCKRCVLKMDHHCPWLATCVGLYNYKAFLLFLIYTSIFCWVDFIVAALWIWTEMLDDSKYIDVDKMLPINVVLLAVLGGIIGLVLSGFTVWHISLALRGITTIECLEKTRYVSPLRKALDRHRYENVLGSEGGDREGFGHRLQDYGGQILDAHANAIPGVTRAEEGEEPTPPPSVSPSGMRMSPAQQALSRSYAEMERQREHDRYQNYLDEEDSEKMPHAFDLGWRRNLRHLFGDRPLLWPVPVCTTTGDGWHWEPSAKFMEARDRVRQRREREAAEQQQYQRDLYQRNMNNSHAWGASAAANWTPNQPLDVVRDPERPNTGVSMKTLAPMSPRLRGQDSEGDMSEEEMHGREDEWRSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHW9</accession>
    <name>A0A8G1VHW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS allantoate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_431009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510579.1">
        <property type="nucleotide sequence ID" value="XM_025658315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHW9"/>
    <dbReference type="GeneID" id="37161717"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH52657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="487" mass="54590" checksum="87D10D07966802B1" modified="2022-01-19" version="1">MNDPKTTTDHLESVEQDQKLDETQWPAQFDPILLRRVIRKVDWMVIPFICITYLITYIDKAMMGYAAVFGLKEDLHLKGTEYSWLGSMFYFGYLAFEYPSVFAMQKLSVSKWLFVNIFIWGGVTMALAACTHFQPFLGLRFVLGALESCSTPSYLLITATWYTIEEQPIRIGWWSTFLGIANAFGGLLAFAIGHIQGNLASWQYQFIIIGAISSVWGIFMSFSLADGPSTARWLNAQEKYVAIHRLGPVHSGTRVSKIKRYQMWEALTDPKTWFFFHCGVCTQVVNGAASNFGSLIIEGFGYSNLVTTLFQIPYGMVILVSNVSAMYIQRWLPGQKRCIVGAIYVCPALSGAVGIHTISRDHKIALLVCYWLTSTYTASFAMIMSLITANTGGTTKRSVVNAIFFISYCVGNIVGPFAFKSDEAPQYTSGIIAMLVAYCVEIFLLLGFAVYAAYLNRTKDGITTTSGQTDSDVDQTDRENVRFRYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VI21</accession>
    <name>A0A8G1VI21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_160573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511162.1">
        <property type="nucleotide sequence ID" value="XM_025654230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VI21"/>
    <dbReference type="GeneID" id="37157632"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF3">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="603"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="681"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="707"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="4">
        <location>
            <begin position="31"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="3">
        <location>
            <begin position="766"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="996" mass="109513" checksum="48B0B0703F21BCBD" modified="2022-01-19" version="1">MADERTTQESPPTWSDSDSAPPAIAEKKRRLPPFLDHFNGRDLKIFFRCWVAVWVACLLIFIHPSLESIGTATFFAALVLLFLPPSGIVFIYLLGALSLFIGICLAWAWGVITMKAAQAARPAAETQAKVAALQQTAVSQAQNSTYSATEIAQRLVYEGYMLDARVTAVTFCLICTFVYFMARLRASNPKAALTAIFGIIISDLFLNYTPLLPSFSGTLPLTLVKPAAIGVGLGLACSILFFPQSTSHVVLDSMEDIVRLLQVPLAMTANTLCKKEEQPNPDDLRMTQAGIIQKYKGMEPSLAFLPLDFSVGCWGAEDVASFQGPLRDVLVAVLSLLDFHIGRIVGEARTQDVLRKYVDKTPDEDEKHTREVGAHQLTQLAQLLDGFRSPDSHPLRKEVVQELVKTSATAIDACAEGLSVVQECIHLVNCRRWFKRPSQAEREKLQQRCEKALEALSKARSVFINEMSDILIGQHEKQPLGEAHHFRPLMFVLVFEEHISNTVQKTEALLARVSTVFQESTKIRVYLPTRFRYAASWASSNEVKAPGSEGTEDDPDRVSADDVTKAAQEKLRVTRGFRTKPRPPLSRAILGTYHWFTCDEGLYAIRMVVVTIALGIPGVIPHSAGFYYRAKGLWALIMGQTGLLVYMADFTFSLIARVIGTVIGGVLGLLAWYIGSANGPGNPYGLSAITAAILVILVWIRLYLPPALMQGGIIGGATFLLVIAYSYDDTHIPQYGNPGVGYNVFWRRLLLVLVGVAASAILQTLPRPPSASRHVCKTLSRAMRTLSTHYALLLTVWAQNSTEGRRLAEPLSLQLAETLVALDGPIKLLGFEFSSSRFDSASLAKVNSLCRSLNRQLSRLLLLSSSLPQEFQEQLARQTGLLDHRLIGQVMAVMGLCEQALKTGDALPEILPTPLFKQAVDSWSRGRRGQEEQIISGEMMRDEGYRRFCVAASAYFGFLITVDEMVLVVKGVLGEAHLVGGLGSREGGWLLGDVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIB3</accession>
    <name>A0A8G1VIB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">feruloyl esterase</fullName>
            <ecNumber evidence="2">3.1.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Ferulic acid esterase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_500102</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the AB hydrolase superfamily. FaeA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="2"/>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512241.1">
        <property type="nucleotide sequence ID" value="XM_025664092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIB3"/>
    <dbReference type="GeneID" id="37167494"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044347">
        <property type="term" value="P:cell wall polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000260">
        <property type="entry name" value="Feruloyl esterase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034476944" description="feruloyl esterase" evidence="15">
        <location>
            <begin position="22"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="85"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH54319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="281" mass="30257" checksum="FE295313DE3F7EF3" modified="2022-01-19" version="1">MKQFSAKHALAVVVTAGHALAASTQGISEDLYSRLVEMATISQAAYADLCNIPSTIIKGEKIYNSQTDINGWILRDDSSKEIITVFRGTGSDTNLQLDTNYTLTPFGTLPQCNGCEVHGGYYIGWVSVQDQVESLVKQQVSEYPDYALTVTGHSLGASLAALTAAQLSATYDNIRLYTFGEPRSGNQAFASYMNDAFQASSPDTTQYFRVTHANDGIPNLPPADQGYAHGGVEYWSVDPYGAQNTFVCTGDEVQCCEAQGGQGVNNAHTTYFGMTSGACTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIF7</accession>
    <name>A0A8G1VIF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Acetolactate synthase</fullName>
            <ecNumber evidence="4 12">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_406269</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 12">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 12"/>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511134.1">
        <property type="nucleotide sequence ID" value="XM_025657328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIF7"/>
    <dbReference type="GeneID" id="37160730"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000053">
        <property type="entry name" value="Acetolactate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="96"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="294"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="502"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH53212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="680" mass="74372" checksum="A590E322C2B50998" modified="2022-01-19" version="1">MMPMRPSKSAMRALHYQRYIASGRMSFTTASAAATTPHRFSAQKRFQSTASAPAENTRPIPSPAFNQEPHRNEVSPLQNRQVPELDDSVNSFVGLSGGEIFHEMMLRLGVKHVFGYPGGAILPVFDAIYNSKHFDFVLPRHEQGAGHMAEGYARASGKPGVVLVTSGPGATNVITPMQDALSDGTPMVVFCGQVPTSLIGTDSFQEADVIGISRACTKWNVMVKSVAELPRRIQEAFEIATSGRPGPVLVDLPKDITAGILRKPIPMNSTLPSLPSAATMAARELSMQQLKGTINRVARLVNISKKPILYVGQGLLARPDGPQILKELADKACIPVTTTLQGLGGFDETDPKALHMLGMHGSAYANMAMQEADLIIAIGARFDDRVTGNISKFAPQAKLAASENRGGIVHFEIMPKNINKVVQANEAVEGDCAENIRLLLPHVEAVAERKEWFDQINDWKARFPFSLYERETAEGPIKPQAVIEKLSDLTAHMKDRTVITTGVGQHQMWAAQHFRWRHPRTMITSGGLGTMGYGLPAAIGAKVARPDALVVDIDGDASFNMTLTELTTAAQFNIGVKVLLLNNEEQGMVTQWQNLFYEDRYSHTHQKNPDFVPMAQAMGVAADRCTKPSEVEEKLKWLIEQDGPALLEVFTDRKVPVLPMVPAGCALHEFLVYDEGMHND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIG0</accession>
    <name>A0A8G1VIG0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polyketide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_500467</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512406.1">
        <property type="nucleotide sequence ID" value="XM_025664124.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37167526"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041068">
        <property type="entry name" value="HTH_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="TesA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF21">
        <property type="entry name" value="NON-REDUCING POLYKETIDE SYNTHASE AUSA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18558">
        <property type="entry name" value="HTH_51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="485"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="1363"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1694"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1798"/>
            <end position="1875"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1363"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1514"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1676"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1897"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1677"/>
            <end position="1709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH54484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2570" mass="280405" checksum="6AEF4ABE0A89B976" modified="2022-01-19" version="1">MANDDLIHKLTWSPAALSKEPLSIAHVVFVVADKESESLSVYQRQLVNEGITTFVTDDAMKIDPLITPGTIVVYIPPTAKSKNEIYAAASQACTGLISVAQQLNHRIISAKSETVKLFSIVPLDRGIGDLVYAPLQGLSRVLKTEIPEIFGGLFEDDRGVFPLSAVKYAQGFDVVRVCEGEARVAYLQPFTDDEPSDKKGLQLHANSSYLITGGTGGIGLATATWLAQRGARNIVLVSRRGLPPSTDSKPVEANSADPISRIAKLKAVGILVHVLAVDISKPNADVTLSQAINDLGIPPIKGVIHAAGTAGYHTLTRCTPTDIADNLAPKVIGSLNLDSLFPPRTLDFFVFTSSVGQLVGFPGQLAYAPSNAFLDALAAHRRRQGDNSMAILWTGWQGTGVWDQNKAAMRRLNKASISRGIADISPDEAFAAWDHIASLKSDHAVVVRVLELEADEPVRHPMLKYITPRKQAYQSTTMDYKEYPEHAIAVIGMACRTAAGNTENDLWQAILEGKSIVREVDEKRFPGVVRDGKMWGSFMSDIDTFDHQFFQRSKREAAASDPHQRVLLETAYHALESAGYFGPGQQQGETHDPDSHTTGCFIGMSAPDHILHLASNPHSPYTGLGMMRSFVAGRLSHYFGWTGPSHTIDTACSSAMVAIHQACRAIQGGECTQAVAGGVHLLLNMESSDALRASGFTSETGTCKAFDSRADGYCRGEGVGVVILKPLARALQDGDNIQGVLLATGNNQNINNTSITNPALASQVALYKDVLRRAGVKPADVSYVEAHGTGTRAGDPVEIQGIREIFGGKDRPSILNIGAVKANVSHAEGASGVVSLIKLHALNPNIPALEPDRMAIPTSPSEWRDNKRLAVVNNYGASGNNASAVVAPPPRQPSSASPTIPSASTWPVFISAASRASLLAYCNTLSRKIIEELPAPELFPHLSFALATRQNRQLRHLFCTLATSLSDIQSQLSDPDKHIVPSAQPKPVVLLFSGQNGDTVPSVGPLYESSLLFRTHLHRCEDVMQSLGLPSLFPVILQGIQGEADLILRHISMFAIQYSCGMSWIDSEVKPKALCGHSFGRAAIIQELWGDDTGSMVAIEADLVSSNTTPEKHLEPFYTIHPDIKLDIACYNGPNNYVVAGPTKYIDHLESYLVEKKASGEKIRFKVLRGMYAYHSSMADTIVDECAKLSASIEFQEPKYPFESCHKTASPSPRPNVVARNTRQPVYFGQAMTRIVDRLGACTFLEAGVNGPIVAMARSALPQAPAQGHHTFLGINGRDLVRSLADATVTLWKTGQSNVQYWLFHRCQRTSYRPVALPAYHFEKHRHWLEYKGLSGGRDNKTGGNMPEHPAVCPHCQKDTADRPFIRQDKPHTEKPGESVFTIDMHSRRYQDLVKGHVVVGTAICPASVYLELAAHAVSILSNNKITSSIVVDDIHFKAPLSLDTQRSVKLTLTNKRQYTWGFGFTSVKNERSILHAIGSISLRDNSSRKADEEKEKKDKWTRMINLLDNDPDTDALRGAMVYKVFGNMVKHAAAYRGLRHLVGKGTEGAADISIPVNELNTVARTPNNNVVDALVMNNFLEVPGAYINCLHVFADEDDSKAYICTSLGSVGPLNKLPEGRYYRVYAQIVRQSSNEAILDVLAFDAQTMELVLSAKDIKFSGISTSTLTKLLAGADPSSTVNGHTDPSQVAETPGSKQPTKSNPGTLSQTLDVPVAEVSKGASLEELGVDSLISSEILASIHDALQVDISVEDFAAATDVASLCELISARVGSDATNTGGQDDQVLLEPEHVSETAKDENLDWQKAAIEILGRSLDVPVADIQMGSQLEELGADSLIAAEIASNINEALDLTILSPDFASLTDVKSFCDLIAHVSGRVPTQAATVSASENTNFAMNNGVTRNGHSTTAFEDNSQIPTKDNTELTHAVFQKVRRRFDSHAKEVKLAGFWDNVYPRQLTIVTAYIIEAFEKLGCPFKKFSHGEKLPSLQETLPRYQREVSRLWEILEEAGLVEKHCGTSIRGPVPHVQDKSAKELSTDLFSNYPQYTSTHDLLDLLGPQLAECLTGKADAASILCVNDKGKELLESFYANDPGLLAANRVLSDFFSTTMKARASGEPFRVLEIGAGLGSAARHLLPQLQASGVPFTYTLSDSSVALLERSKTTLQDIEGLEFRQYNIEEDPHVDLLGRYHVVISNSYAHATRDLQNSLVNIRKLVRPNDGCVALIEATQKLAWYDLVWGLLDGWWLFDDNRTHALQSPWAWRSALHNAGFKHVDWSESSSRESRTFRVICGMTAEPERKCPAEATSMLLHRGTSASGKRNLFLAPDGFGSGAVFGGLGPLLGSVRNVSVYALNSPFMHSKPDPDQPLAIEELAAIYASEIKRRQPEGPYLLGGYSVGGVLAFEVARQLLEDGNHVEKLFLIDTACPTFVRYFPDALVKFLDSIEQVRVGNGSEFRPNRRGRLVANDHFFLARQQMRAYQVRRLPGRKMPQVVLISAKEGADKQEGVTRPAFLPEDQKAVDWFLNDRTDEGCFGWNEVLDNIKVVRADGNHFTMMLPSIISGWGADLARMLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIN7</accession>
    <name>A0A8G1VIN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative lipase ATG15</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Autophagy-related protein 15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Putative lipase atg15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BO85DRAFT_105026</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512468.1">
        <property type="nucleotide sequence ID" value="XM_025653814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIN7"/>
    <dbReference type="GeneID" id="37157216"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000129">
        <property type="entry name" value="Autophagy related lipase Atg15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0072">Autophagy</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="22">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RAH54546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="596" mass="64549" checksum="843D095437BE9D58" modified="2022-01-19" version="1">MKGLRGQNKKPSWGNTRLSDLLWSVTLLPGLISAYQPVYLGSRPASPFLPPQIPLGDSPPLSDTHEFTLRHIFHRGTYQDPDLHRRLDITPDTRLRAVSDEGVETDVVTPNTPLVASSQPLTIERLADRRLSVIEEHLVTARSSGSAVALSPSDWVMDTLPGPNVTEKKTVVALAMMTANDYIEVPGTGDWQDIHGRFNHSGSFGWQGDGLRGHVYADKTNSTVVISLKGTSPALFDGEGTTTNDKINDNLFFSCCCGQGGSYLWRQVCDCQTTLYNANLTCIVEAMLDENRYYRASIDLYSNITEMYPNANVWLTGHSLGGAVSSLLGLTFGVPVVTFEAVPEALPAARLGLPSPPGHDSRYPQSRKNTGSYHFGHTADPVYMGTCNGVSSVCTWGGYAMESACHTGQMCVYDTVEDKGWRVGLSKHRINYVIANVLAGYDDVPPCAPEEECYDCELWKFFRSNGSEITTTTSATSTSTSTTTSRTSTCKTPGWWGCLDPTTTGETTSTSTSTSTCKTPGWFGCKDPTTTSDITSAPTITTTEPPMTSTTTCKTPGWFGCKDETTTPVMIAPAATLTITEPPVTSTPTGKHLGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ63</accession>
    <name>A0A8G1VJ63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_507561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825085">
        <property type="protein sequence ID" value="RAH52418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510340.1">
        <property type="nucleotide sequence ID" value="XM_025664411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ63"/>
    <dbReference type="GeneID" id="37167813"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041:SF1">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="618" mass="68227" checksum="DCC2A70344FDF354" modified="2022-01-19" version="1">MDSPSSATPSPTKALNPLSPDRMNQQIGLGSPSMSSDIFNIQRKTPRGLTDVQAKVAYLNNLSRGNSPAQGSQPSAASTAALQRAILGREEAESALANVSAQLSEAQSRERRISERLESLLEELQTTKERQAHERSIFEKEIRKARKEAFRAGSVLVKTQEELKNARNEAKGYKDEAQAERAAKEQAKQEAFERAYAIAGLTEEMEVLKEQLRAAEANNHSQKLEAQAQQKKNDIGRMSLTEGDLNLLLTPTPRRPKRSAEEIANPPQANVAESSPVKDTPPKRQRMSDVTPRKEAAEITTLDVHEEQIAELEETLRCERQLRVDAEGMLEFLRLECHFKRCTCRLAEQKSVPHTHEPQSVATTKKDELEHPKHRKNDQNALAAPEEPSPSHTPKGEPRYDVDDDDDDEPPEEPLITFSPATGTFHTFPSPVRGSPRKANEATANDHQSPAAYPEHGIDARVMSGSPAPKYGSLQRQAPFDPITDREATPKAHPSPAVVDVPWDPVMPIGHEAGTPERHNDPTKVPLRDDGGSNRFSDVPGTPISREEALAQIRARRERANTMKRSVSASESGLRSGGMGVTPVRSARRYPGVQNPDASDGSIRSRRDMSAPIQMSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJB0</accession>
    <name>A0A8G1VJB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_440762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513336.1">
        <property type="nucleotide sequence ID" value="XM_025658786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJB0"/>
    <dbReference type="GeneID" id="37162188"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH55414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="290" mass="32958" checksum="EE4E90FED0284643" modified="2022-01-19" version="1">MGGVCPLAMTIQSPNGVTGTVSPPVTHSSWLLPGPLSLCSNIHFLVIHLPVTLSPSKSLRFWPPFYYSIQETLRIERPRYRTRTPLRRSATMPAPIEQPSEPVVLVRDPEDDESYVISAYEGHADHCTRCADPMTAYEEKRSLCKRGAQYARDVTEYLRSKNGKIYSVVDLERNRSTLVRVPLKCVAVRQLLLAIENGLRVNTKEEVTARERPIISHEPAPVRRTTTQEDVACTAIIEREPRSLRRHRVIVYTSPRSSPSRGSLYEADAADRIARVNRSSRIYRPSDYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJE4</accession>
    <name>A0A8G1VJE4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-conjugating enzyme type E2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_451652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513263.1">
        <property type="nucleotide sequence ID" value="XM_025660640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJE4"/>
    <dbReference type="GeneID" id="37164042"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000061">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="9"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH55341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="194" mass="22034" checksum="94B010046F7AC10D" modified="2022-01-19" version="1">MRTRFRIWDISIAFRGTCADGLHRLMSDYEVTLVNDNRQEFYVRFKGPEETPFAGGHWKIHVELPDQYPYKSPSIGFVNRIFHPNIDELSGSVCLDVINQTWSPMYDMINIFEVFLPQLLRYPNPSDPLNGEAAAMLMREPKSYEAKVKEYVAKYASKEAVDEAGEDTESEDELSSAGSYESGGEEPAGTMDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJV0</accession>
    <name>A0A8G1VJV0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosome associated DnaJ chaperone Zuotin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_472228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511030.1">
        <property type="nucleotide sequence ID" value="XM_025662540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJV0"/>
    <dbReference type="GeneID" id="37165942"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23953">
        <property type="entry name" value="zuotin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.840">
        <property type="entry name" value="Ribosome-associated complex head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032003">
        <property type="entry name" value="RAC_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042569">
        <property type="entry name" value="RAC_head_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058871">
        <property type="entry name" value="Zuotin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16717">
        <property type="entry name" value="RAC_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26185">
        <property type="entry name" value="Zuotin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="101"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="323"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="323"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH53108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="447" mass="51183" checksum="0F033AC7C67382F9" modified="2022-01-19" version="1">MATVQTINVTLPSLPSGWSADKDFKAVGTVSAATQRNLEPVGPHFLAHARRKRHHRTFSEDERIQAQQNVKSTEDEEDDDISEDEDPVMLSRDAKDWKSQDHYQVLGLSKYRWRATPEQIKRAHRKKVLRHHPDKKAAMGDRDENDSFFKCIQKATEVLLDPTKRRQFDSVDEAADVEPPTKKEAAKGNFFKLWRPVFESEGRFSKIQPVPQLGDENSTQEEVETFYNFWYDFDSWRTFEYLDEDVPDDNENRDQKRHMEKKNANARRKRKTEDTTRLRHLVDECAAGDERIKKFRKAARADKDRKRLEKEAEIKRLAEEKEKARLEEEQRKKDAEEAAKAEREQNKKAKEAAKNAAKKNKRVLKGSVKDVNYFGEGGEPSAAQVDSVLGDVDLIISKIDAEEIAGLAGRLTAAGKDAAAVKNVYAEEVKRLVGAGKLKEGEAKFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJW3</accession>
    <name>A0A8G1VJW3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-1,2-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_375468</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514011.1">
        <property type="nucleotide sequence ID" value="XM_025656171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJW3"/>
    <dbReference type="GeneID" id="37159573"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH56089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="392" mass="46042" checksum="A9B1853DE4749DCD" modified="2022-01-19" version="1">MAIGPLRYLLFAITGLAVFFFISRSAIPIPENIGTKLNPATYKDTFSSSPSSHNDALSSSGPIKDIPTDRVNATFVTLARNTDLWEMVKSIRTVEDRFNHNYHYDWVFLNDKPFDDEFKKVTSALISGNTFYGVIPKEHWSYPEWIDQDKAKKVRQEMGEKKIIYGDSESYRHMCRYESGFFFRHPLMLNYEYYWRVEPSIELFCDVSFDPFRYVKENDKKYSFVLSLYEYYDTIPSLWGTVQKFMEEHPEHIADGNSMGFLSDDGGKTYNKCHFWSNFEIGSLEWLRSKEYIDYFETLDHAGGFFYERWGDAPVHSIAAGLLLKKEQIHFFNEIGYYHVPFTHCPTGEQLRLDLKCHCNPKDNFDWKGYSCTSRFFQVNDMDKPKGYENES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKY7</accession>
    <name>A0A8G1VKY7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_36768</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515181.1">
        <property type="nucleotide sequence ID" value="XM_025655828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKY7"/>
    <dbReference type="GeneID" id="37159230"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="106"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="331"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="372"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="417"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="505"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="545"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="187"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="751"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="818"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="766"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="832"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH57259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="902" mass="99589" checksum="7E77CA00AE2FE64A" modified="2022-01-19" version="1">MARDTAQTPIIPRPRLLQGAASYPSDLTAPSLSAPFKLDEGYSDETRSQPDKDFLNSPPDDVMPLPDWVNAYNEAERAELAYKLLRTLRASTVASVVEKLAPLLHMDPVLKLPPEITAEIFSYLDPQTLVTASLASRSWRDRIFDTRLWRDLYISEGWRVDIDAVHTYEQEHSGLESPQLRKSRLRHIDPDLGEPKQKKRVPPSWLDSRATGSLDNNEAVQGNGLQPSAAADVEGDHHMSDASNDRGPVLAAGQQSSSARHESSGTAQLKSNLQQISTNASPPKSSLLIRMPNGAAKMNWPHLYRVRRRLEENWTKGRFTNFQLPHPNHMEESHQECVYAIQFTDKWLVSGSRDKTVRVWDLDTKRLWHPPLQGHSKSVLCLQFDPRPSEDIIVSGSSDKNVIIWRFSTGEKLHEIAPAHDDSVLNLRFDERYIVTCSKDKLIKIWNRRQLTPMDKDYPSVFQGSGVSYPSYIVDTSDIPAFILEAEIAKNHIRTLAPYSLLMILDGHTAAVNAIQLNEDEIVSASGDRLIKVWNLRNGACRKTMIGHEKGIACVQFDSKRIISGSNDDTVRIFDHASGAEVACLHGHANLVRTVQAGFGDPPGAEEALRLEALAVDNEFRDAQRTGANVDLGPSALRRAGYQQNTNGSRNPRDIKALGAKIPPGGGGSQWGRIVSGSYDETIIIWKKDNEGRWVVGQRLRQADAAANASYSHLDSSARQTIARANAFAQAHQAQQAQATMAAAAAAAAISTGGGAPQQPQPPRLSTNNSNSNDPSSQNAPWPAHLALNPALLISNNLPPTVQQSTPQAQTQAPAPIMHAGAPMRPPPLPPHAQQHQHQQQQHPRVRAFPAAPQQPPTSRIFKLQFDAHKIICASQDPRIVGWDFTADDEELKEACQFFTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM13</accession>
    <name>A0A8G1VM13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CSN12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_395376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516291.1">
        <property type="nucleotide sequence ID" value="XM_025656956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VM13"/>
    <dbReference type="GeneID" id="37160358"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000366">
        <property type="entry name" value="COP9 signalosome complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="246"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH58369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="453" mass="51147" checksum="CB3F57F12BC0BE48" modified="2022-01-19" version="1">MSNIFDDFKEGQKIGSGARLAASLSPVATAEYPDRLKSFYYFSNAVHVSADLRYSLFQANGLRLPKQEQNSWVDIFTAYWKAVGEIVRFDDSPRHASWVKVFDAWKDTANQLIRGYSTGSLQAWTVPCLYSVGRYLRAFAMKADAELSAQDSVTFDDRFQDDATDAKNPKLEEATRVLNRMFTLCLSDRAPIEESRKWGIYDTTNLLFKTYFKLNTVGLSKNLLRALNASSADLPGLDAFPKSHIVTFEYYVGVIHFLDENYAEAEEHLSYAWRMCNKSATKNRELILTYLVPCHLVTTHTLPSKKLLAPFPRVEKLFRPLCDCIKKGDLGGFDAAMTAGEEEFVKRRIYLPLERGRDIALRNLFRKVFIAGGFDEPKEGQSPIRRTRVPVAEFAAALRIGTHADDRLRVDIDEVECLLSNLIYKGLMKGYIARERGMVVLSKGGTAFPGTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM32</accession>
    <name>A0A8G1VM32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Manganese ion homeostasis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_419087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516336.1">
        <property type="nucleotide sequence ID" value="XM_025657841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VM32"/>
    <dbReference type="GeneID" id="37161243"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="114"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="544"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="594"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="654" mass="73187" checksum="D0EE1D10A0392D0E" modified="2022-01-19" version="1">MSYSYSHNAIADSYRPARPGSPAWSSGSSERDQSPPPWPKRWASDLREATSTRHGILSLFKQVARYVFTISNALVVLWICTLWWGERTVFQDSVKACTWGNWERWPQDAIPHHVAFIADPQLVDPHTYPGRPWPLSTLTVKFTDQYLRRSFSSIQKELGPDSVLFLGDLFDGGREWATASSSSPEKRYKKYKDRFWKKEFHRFVKIFVDTWKDGDDHIRHPLGRRLITSLPGNHDLGFGSGVQIPVRDRFQSFFGKSNRVDVIGNHTFISVDTVSLSAMDQPDPETGSSGTGSGDGEQPNEHIWRDTQDFLDRMNVHRGRAEVEALRMLANKTEGRQFQHRAVDILEPSVDPQLKPEVAGFPTILLSHVPLYRRPATPCGPYREHYPPSGEGLEEDDRNAIPMGRGYQYQNVLTPAISRDIVSKVGPNLVQMYSGDDHDYCEISHHEFSGSPKEITVKSLSWAMGIRQPGFVLTSLWNPLDLATGEPDGSANAGRTVQNHLCLLPDQLSVFIYYGVILGFTLCVLLVRAAIIVKYLPSGASPDEPILPLSEHRSPPPQRAARYKTPSSGTSSSTFPTPRGLASRAVNAPPIHAAYAGSDEGKVGSAKWKPSRGGSRRPGASASQMTLIQEEFLASVMGVARIALCWYFFLVWRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM65</accession>
    <name>A0A8G1VM65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Copper fist DNA binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_488205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515392.1">
        <property type="nucleotide sequence ID" value="XM_025663511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VM65"/>
    <dbReference type="GeneID" id="37166913"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="202"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH57470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="531" mass="57428" checksum="07B57F504A9250BF" modified="2022-01-19" version="1">MLIDGEKWACEACVRGHRVSSCHHSDRPLTHINKKGRPVSQCAHCRGLRKSRTTHTKCECGDKKKNCHKNDLDPHVTDKRDHKQDSRPKCGCTHGQRCTCALKKEPHLDTVPETGLPPPPAAALLDQPKKPQLTSTKSESTLTIFRDGHHKPAHKHNDMAHKCGLPYTIPRSHTIHAGDVARRSVDHLPLVQPTMLNEGFANQQQPAEQSPARGQHRRVKSEHGSPESAPVVSPDNVPTTVPPLDISSFFPQVQTAENAGDVGVPEPVSMPMKTPLDPLVTSGLPFDMSSFSSFPTTATSPVNCVAFQDPYKEPFFTSPEGDVSLQSTAFSAPPVDWSSFPLYSSEVPAATSTQAPSYASFDYNSMAPGFPAPSSSGDISEADEFAPIPGLGRTGSDLHDLNSVSEGSDIDHFRISSASSFIGLPQAQLLASNNLESIDIDDFLKSANESTAALEHQLQATMGMEAKQLPTEDAFAMSNAETFKPVTTPTASMSMTTPPTEAAWNVGLFDPNTAPMSENSNGNFYVPPWVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMR3</accession>
    <name>A0A8G1VMR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar transporter chaperone complex subunit 4</fullName>
            <ecNumber evidence="3">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polyphosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">SPX-dependent polyphosphate polymerase VTC subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Vacuolar membrane polyphosphate polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_418010</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19574"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the VTC4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="3"/>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516908.1">
        <property type="nucleotide sequence ID" value="XM_025657793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMR3"/>
    <dbReference type="GeneID" id="37161195"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000001">
        <property type="entry name" value="Vacuolar transporter chaperone 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="697"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="727"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="18">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="515"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH58986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="808" mass="92698" checksum="23F586BD04DD142F" modified="2022-01-19" version="1">MRFGEHLRSSMIKEYYWYYIAYEDLKKALKTGYVTEPTPENARPDRQAWSEDDEKHFVTLLESELDKVFNFQRIKSAEIARRIQASETEVNDVVSRLDNSSSSRSDSASNSRSSRRPPSDEDFLLLEQVLSDIIADVHDLAKFTQLNYTGFQKIIKKHDKQTGWHLRPVFAARLNAKPFFNDNYDALVVKLSKLYDLVRTKGNPVKGDSAAGGSQQNFVRQTTKYWVHPDNITELKLIILKHLPVLVFNPRKEFEEKDAAISSIYYDNTDTWELYQGRLKKTEGAEAIRLRWYGGMESDQIFVERKTHREDWTGEKSVKARFSLKEKHVNAYLSGRMTVESIFEKMRREGKKSEEEIDNLEQLAREIQYRVITRKLVPVTRSFYHRTAFQLPGDARVRISLDTELTMTREDNLDGRSRAGDNWRRMDIGVDWPFSQLPPEDVERFPYAVLEVKLQTQAGQEPPQWIRDLTASHLVEAVPKYSKFIHGTATLFPDRINLLPFWMPQMDVDIRKPATRKFGIQRPPASAPLSTTETPEDDESDEEDSNEARWVDSTDTAEATTADQEALFADTDGNALDIEERVAAQPLPGDEDYPLYDSDAESVDSDELEEARRVGGTYYYKQLAKYYVHNAGNAMVHCFTALIPRPRPTSMPPPEQNGIAVMGNKRTVKRFQAPKGKRIHVPVRVEPKVYFAAERTFLSWLEFSILLGTIAATLLNFGDDYITFGSSWAFTVLAAVALLYSLMLYVWRVDKIRKRRDVKRVYYEKWGPTVVGLGLVVIVMANFGLRARQAGFLAKDGDLDDAPHGGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMU5</accession>
    <name>A0A8G1VMU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dimethylaniline monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_394535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516998.1">
        <property type="nucleotide sequence ID" value="XM_025656927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMU5"/>
    <dbReference type="GeneID" id="37160329"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH59076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="471" mass="52673" checksum="322DE2E2AE2EEF63" modified="2022-01-19" version="1">MTPKYRRIAVIGTGPSGLSAVKALHDENTFDKIRVFERRDRVGGIWHYDPAPDPFHAPGSPSQTPNIPTSLPQFTSPRPEDTSARTGIYSHLDSNVGAKTMAFTHTPFPEINSSTSIKTFGPSNASRPFRTVANYLEDLFIPYLHLVSLSTTVERVEKTSHEWTLTLRKTGQLYRGLPQDYWWTETFDAVIIASGHYNVPSIPSIPGLSTTALTHPHAFEHAKAFRHADNYVNKRVLIIGGNVSAADLVTELHEIVSGPLYISQRGINPALENAWTLPNVERKPTLSRLEPTTASGSTNNTVTAHFTDGTKLESLDRVIFATGYTASYPFLVPDPVTANNRVAGFYQHIFRISDPSLALVGQVRAALSFRVYEYQAVAVARYFSGRAKELPSQAEQDRWEFERLKIKGNGVAFHEIKPDFREYFEALLEIAGEGAGLAPFEDRWADEAFEILKAKDEYWLRLKRGQNRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNL0</accession>
    <name>A0A8G1VNL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="10">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_467629</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="10"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH60004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517926.1">
        <property type="nucleotide sequence ID" value="XM_025662200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNL0"/>
    <dbReference type="GeneID" id="37165602"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF20">
        <property type="entry name" value="[3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="281"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH60004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="472" mass="51707" checksum="CD5673E4FF9AB40E" modified="2022-01-19" version="1">MAVRRALQTASRGASLRYHCFSTFPARSFSSSPPVQTTTSPRHAFAYGANDEVARLAASRRRPLTLADLLKHGRPPLCKDALLASANFTLSLLPARLASRIEALRNLPFIVVSNPHVSKIYNNYLHSLSTLLPYQQRQVTTLEEENQFAEVLADLVHTHTNTIPILARGFLECRRYIDPTEVTRFLDTHLRARIGTRLIAEQHLALHFASQPVRDDPSEQQERPKDAAPSNYIGVIDTALQPARIVKSCEDFVGEICELKYGVRPRLNIGGQPDASFAHVPVHVEYILTELLKNAFRAVIESGNGNEPIEVTIAAAPDVPASPVHDPKAKEKWSHSDSDTGFHMDTVVGTADANESIKCWSPSQQSITIRIRDRGGGIPPEVLPNIWSYSFTTFSDYGMNGSENGSMDALNTISGSGGHLSSIAGLGYGLPLSRAYAEYFGGSIAVQSLWGWGTDVYLTLQGVAMPSCVPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNX3</accession>
    <name>A0A8G1VNX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_517771</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518123.1">
        <property type="nucleotide sequence ID" value="XM_025664934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNX3"/>
    <dbReference type="GeneID" id="37168336"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000010">
        <property type="entry name" value="Methionine aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="12">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH60201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="379" mass="42189" checksum="53BD6084F5E7FB3F" modified="2022-01-19" version="1">MTSKFVAKRRCLGDGCDNECSTLQCPTCLKLEIRGSFFCSQDCFQRSWKIHKAIHRAKQTILYNPFPSFNFTGSLRPVYPLSERRAVPNTIQHPDYWQGGIPQSAQSFYDRRAKFTVLDKAGQDAMRKVCRLAREVLDIAAAAIKPGVTTDYIDEIVHKACIERDSYPSPLNYNFFPKSVCTSLNEVICHGIPDQRVLVDGDILNIDVTLYHGGYHGDLNETYYVGDKAKADPDSVRVVETARECLDLAIELVKPGALFRAYGDVIEEHAQKRDCSVIRSFCGHGINTVFHCLPSVPHYAGNKAVGAAKEGMCFTIEPMVALGTYRDMIWPDNWTAVTMDGKRTAQFEHTLLVTADGVEVLTARLPTSPGGPVPYPVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNY5</accession>
    <name>A0A8G1VNY5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phytoene dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_511623</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 4">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516984.1">
        <property type="nucleotide sequence ID" value="XM_025664612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNY5"/>
    <dbReference type="GeneID" id="37168014"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF1">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH59062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="525" mass="59802" checksum="FF18D7E6FB57E16D" modified="2022-01-19" version="1">METTKSPASVIVIGAGAGGIAAAARLALEGFQVKVVEKNNFVGGRCSLLHKDGYRYDQGPSLVLMPEFFRQAFQELGTSLENEDHDHIELSRDIPRLEAQMEYHEGPQGFSRFCTFLAESGLQYELCKESVFKQSFPTLRSMFHPALFKGFLHIRPWTSMYSQAAKYFRSEKMRRVWSFESMYLGISPYRALGAFSLLPYIEMTDGIWYPRGGFQRVLHALSEVARRLGVEYLLDSPVAKIELSDDNAKATGVRLETGEVLQADIIVVNADLVYAYNHLLSPSREAERLRKRSTSCSSISFYWAFDEQIPELRPHNVFLAGRFRESFDRIFDDHDVPEDFSFYVNVPSRVDVTAAPAGRESVMVLVPVGRLVDTLGRDEEEKRWNILVAQTRDIVLDTIEARTGARNLREKLVHEIVNSPLTWREKFNLDRGAILGLSHDFDNVLWFRPQMRHFAIKGLYFTGSSTHPGAGVPACLLSGKFVVQEIMKDWMEAKSTTKDYRRWVMLAMAFGLLTVLSIARSSYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP46</accession>
    <name>A0A8G1VP46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phytanoyl-CoA dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_447378</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517387.1">
        <property type="nucleotide sequence ID" value="XM_025659710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP46"/>
    <dbReference type="GeneID" id="37163112"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF45">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH59465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="310" mass="35616" checksum="96A80086FB55BA9D" modified="2022-01-19" version="1">MSFNPNKYGDEVQKVSRDTPLEEIIYLLKRDGGVFIKGLISEEDVDQASQEAKPRLDADVEWNGSFFPAQTQRAPSLIAHSSTYTKTQVMNPLFHQVCEHFLTSRRWYWWGDEKKMSVSKPYVHSCTAMRIGPGAKAQPLHRDDYINHRFHTEVGQWDDVRDMERESAVGLFVAGCRVTRENGGTQFIPRSHLWGTERTTPPKVEQCIFADMEKGDGFIMLASAYHGGGSNITEDEYRLTFATFVVRGYLRQEENQFLAVPADVARTYDRETLEFMGYAMSEPACGYVDQMDPIYHLCPELKENERPRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPC2</accession>
    <name>A0A8G1VPC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Snf7-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_445984</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518751.1">
        <property type="nucleotide sequence ID" value="XM_025659392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPC2"/>
    <dbReference type="GeneID" id="37162794"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH60829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="17476" checksum="2C6629E7844FC785" modified="2022-01-19" version="1">MLLTLRAILDLKNQRDKLHQYQKRITVLTDRETEIAKQCLARNDRKRALLALRRKKYQESLLDKTDKQLEQLEQLTGQIEFALVQKDVLFGLQQGTKVLQTINKEMGGLEGVQKLMGETEEARAYQEVSFYCQWLFEKVILDWMLTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPF7</accession>
    <name>A0A8G1VPF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyrimidine 5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_447515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517554.1">
        <property type="nucleotide sequence ID" value="XM_025659742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPF7"/>
    <dbReference type="GeneID" id="37163144"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.450:FF:000001">
        <property type="entry name" value="SDT1p Pyrimidine nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01993">
        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01132">
        <property type="entry name" value="C1.5.3:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="240" mass="27366" checksum="ADE414F01E65FC5F" modified="2022-01-19" version="1">MATTSSPASAPLDPRPVFFFDIDNCLYSKGCNIHDEMQKLINQFFIKHLSLNSDDAHMLHMKYYKEYGLAIEGLTRHHKIDPLEFNREVDDALPLDDILKPDPKLRQLLEDIDRSKVRMWLLTNAYVTHAKRVVKLLQVDDMFEGITYCDYGSLPLVCKPSQAMYERAEKEAGASSTSECYFVDDSGLNCTHAAARGWAVAHLVEPGIPLPHVPASQYMIRSLEELRTCFPNLFKTKQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPL6</accession>
    <name>A0A8G1VPL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_458000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517882.1">
        <property type="nucleotide sequence ID" value="XM_025661556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPL6"/>
    <dbReference type="GeneID" id="37164958"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="947" mass="105950" checksum="DE2F5BD5CB4A2E3B" modified="2022-01-19" version="1">MASIFEAADIPELTKLARDLYLTCNSISGDAPDGFNQLVASLESLHSVFQTLKDDVSSSKIELSESDEECKHTLHRCLNACSGTLQQLKEVVDMYRNLGFENGRQLWQSIDWMTQQAFIDDLKSKIVAHTCHLGVCVGSLTKPSIERSESSATKDSAKDIPPPTPASWQAHDDVSPISISVSTPRQQNVFILAELEGTQPSRSNPAAPQSACPPEDPSHVSASSESVVSGHSDTSSFTATTYTSPTSPATSTYSPSQSIVPEVFSTEKEVVWSRESTPWGSPGHSGADAIQELHRRQLREQLFRSLRCEPRDKMHQPDAELLASFDHIAHKEERAQQLTARCWLLVAVWWLLKLLLEDEIRKMISDLSDGLKEDFGQFSAVDVPNYAAIHSQNLDFWEPIQPEEMIGKDGQPAKPGNFCYITVELEDAGKEDEQVLFRTFVNAGIGAKKLRMRSRGAPYMLLLSTKYGESEPKISLCNQYGTFCLQRDLAPGDLAQLIQVSNASLTNLSVPKPTEPLTLKFDAMTLSISFQYMSDIMQVISMPKAYFDAVQIREPLDSDQFTEKVIFKIPAESVEQLRMPSMVSTSPPTVHRSCEVRILERSFGEAWRSIRRMVISSSIADKPGQATEFFMPLSHVQVSRTAASGFILLKWSDTGQERSSKTDGNYHPLFTYVYDGSNPNIGLGIKFRSQEAADKLERAVLGLSQKPAFTWSQAKSSGQVYEVADIAPDEKRYKAVMICRTRAEWKQCSLHYLFRDMDYLYDHSNLRVRFPRALFATYISSHVDQLYRADGRVYFSHCEKEFRDMTVEFSEEPVLMAFMSSLASTYKLVFSRGATSLTTKEKLLVLGPRKSVKGDSQVQLWRDGNTIRLASRWSDRITDRWLTMTIPPCEPSRAGNLVSFPPSSYSRGMVLNMTKIASGAAKNQNREHKTGPITITFPHLKGTPAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQG0</accession>
    <name>A0A8G1VQG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1000 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_179170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518752.1">
        <property type="nucleotide sequence ID" value="XM_025654340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQG0"/>
    <dbReference type="GeneID" id="37157742"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.470:FF:000003">
        <property type="entry name" value="DUF1000 domain protein (AFU_orthologue AFUA_1G09230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="23"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH60830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="221" mass="24370" checksum="76254041E428521A" modified="2022-01-19" version="1">MSGHHHHHDHGGHCHGEDGHDHSNDITPAIQSLLYSQIQFDSITTLNEASPKSGAAIVKKTWAERLDDEPELESDADEQLLMYIPFTGQVKVHSLLIYTAPTPSAPKTLKLFKNRDDLDFGTASDLKPTQTVEIPQPMPGADVFELPLNRAHWNATTSITLFFEDNWSDGEEDVTKVGYIGFKGQFMALNREPISFLYEAAANPGDHVAIQGVNGVGSRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQG8</accession>
    <name>A0A8G1VQG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_445220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519743.1">
        <property type="nucleotide sequence ID" value="XM_025659205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQG8"/>
    <dbReference type="GeneID" id="37162607"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH61821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="748" mass="83595" checksum="9A53F8D3004D540C" modified="2022-01-19" version="1">MSSESPQVDMAPPQPDSGDQNATPDADTAKRKAEPANGTHTRSKRNRYISIACNECKRRKIKCNGQVPCQRCGHLNLECRYAPNCCNNNFKDSEEFRSMTDQIKTLQDQVNSLFTNLKDLRSQRSSIDSPNFDAFSRDGSQSVFTPMQAPLSKPRIRHPRFQGPTSSAFNFDVARSSLQNMGIAPPEEVIPDDLTTAQVTPAGSPPHVGPSFLTMHPTKDPIWSIKRDEALRLCRVYEEEIGIMYPLVDIEQIAQQVNLLYTFMESAIRTGFAQRGLPGADGLTDDSTVLLKMILAITLIVEGGGQSELGQRLYLSVKPIAESKLWDTLDIKTIQIYAMIATFHFHMDDDAMAYRIIGLAARMCLEMGLHRRDALNKMFPDEEQWPAVVKTFWTIYSLDRRWSLGTGLPFNIQDEDIDPNLPEPDASLPYLKSMISYNRISSKIWYSGLGSEGATDIRRDEIGYLDYQILQWYKQVPDALKFYPIESPKNGHVESTNRGLRRLRVLLYLRMNQLRILIYRPVLHSAASIAEDKGHAQTVVDVAKDTIRVLTRLNQTSDIYRSQQITFNYFLVAALAVIFLAVCHAPTEFNRQVRDEFYMALNLISGFSTKSYVSKRLWKAIKGLRKIGERLGVLMRPFGSDSNDPHSSAAVAMAGLAGHQIEDLSVYGPMNGIGELGNSPLNGLQMSHELTNLFEAVGGFGNFMASGTPAEGINGFVGHDGEIQNTGEGLSGVLGDEGEWSRVIRDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQV6</accession>
    <name>A0A8G1VQV6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N,N-dimethylglycine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_506728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519084.1">
        <property type="nucleotide sequence ID" value="XM_025664376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQV6"/>
    <dbReference type="GeneID" id="37167778"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF193">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="399" mass="42825" checksum="56B775C5E56843BC" modified="2022-01-19" version="1">MQSTQEPADIAIVGAGIVGSALAYYLSSNNKTKKIILVDRSLTPLNGSTGHAPGFVGQYNDSAILTRLARDTVQEYTTIAGGFDTIGGIELATSQTGAERLQRRYDSARAAGLPAELISPEEAARMAPALIKKEDVTSALYFASDGAANATCITRFYQDEARARGVECIEADITGIHKDGNCRVDGVNTGTAGFIPAKTVILATGIWAPELLPDINTPIPIVPVAHPYMYGPYHDQKKVPSLWIRWPDHHVYARDHGPFYGLGSYNHAPVAQEPKDTAIGEWISEFDNTLKDALGFIPPETGLTPRKTFNGIFSMTPDNLPLVGEVPGLEGVYLAAAVWVTHAAGTARFLCDVLEGKEVDGEIKRGLDPGRFAGRDGKTLRKVALGGYNEIYRVGGAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRB6</accession>
    <name>A0A8G1VRB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_388645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519609.1">
        <property type="nucleotide sequence ID" value="XM_025656718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRB6"/>
    <dbReference type="GeneID" id="37160120"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="34"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="472" mass="51032" checksum="C9CB6A233D7E0BEC" modified="2022-01-19" version="1">MPEWTGLYTAISNGEVLMPSDDGYASSLRRWSKAAELKSCVVVKPACAEEVAAAVKFASASQLSLAVCGGGHSTSGASSSEGMLIHLGNMRRVDADETSMTVSFEGGCLWADIDKPLEARGLAVVGGAVNHTGVGGLILGGGHGWLTAKHGLAIDNLIAVQIVTADGSILDASETENEDLFWAVRGAGAQIGVVTRFLYRVHHQGEVWSGILAFAPDSLPGLLAFANEFHNRDNREGHCLTIGVGHTLDGTTRILTAIPLYHGLQGGAKSYFSGLLNMSPIMDSTKMMSIAEVNTLQNPLCEYGMRRLQGSANVTMPLQIEAFQQMADMVWSFHDDHPNVTVCSMAVELFSTHKLREVPLHDTAYANRGAYYDVVTMFGWTDSSLDAAVRQFNAKLCAVIRNINGYERQSHCEGDHLEAGPVGRYLNMENGPVKPTDAYGDNLERLRMVKNRYDPENIFHKWHGVVSGDCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRJ8</accession>
    <name>A0A8G1VRJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AP-1 adaptor complex subunit MU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_410483</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520913.1">
        <property type="nucleotide sequence ID" value="XM_025657483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRJ8"/>
    <dbReference type="GeneID" id="37160885"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="167"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH62991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="446" mass="50529" checksum="5AAAFD6D70AD0D8C" modified="2022-01-19" version="1">MASAIFFLDLKGKTLLARNYRGDIPMSAVEKFPILLSDAEEESSAVAPCFSHEGINYLYIRHSNLYILALTKKNTNATEILLFLHKIVEVFTEYFKVLEEESIRDNFVIIYELLDEMMDFGYPQTTESKILQEYITQESHKLEIQARPPIAVTNAVSWRSEGIRYRKNEVFLDVVESLNLLVSASGNVLRSEILGAIKMKCYLSGMPELRLGLNDKVMFETTGRATRGKAVEMEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTQVKPLIWVECLVESHSGSRMEYMLKAKAQFKRRSTANNVEILVPVPEDADSPRFRTNIGTVHYAPEKSAIIWKIKQFGGGKEFLMRAELGLPSVKGDDEHGGGMTGGFGGSMGGTGQGKAKRPINVKFEIPYFTTSGIQVRYLKITEPKLQYPSLPWVRYITQSGDIAVRMPDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VS45</accession>
    <name>A0A8G1VS45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatidyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_366544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518350.1">
        <property type="nucleotide sequence ID" value="XM_025655785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VS45"/>
    <dbReference type="GeneID" id="37159187"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF4">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH60428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="442" mass="48886" checksum="529C9CD5511586A4" modified="2022-01-19" version="1">MTTADGYATPRVSRLSSLDASQADLYGGPSVVVPPKHLMASTISHETAMELEAAKQHFDEEVSSEEGSPRVAPPVTKKALTTADDFALAFDIDGVLIRGGKAIPEAASALRYINGENPYGIKVPYIFVTNGGGKTEEERCVDLSRQLELEVSPGQFICGHTPMREMAERYHTVLVVGGEGEKCRIVAEGYGFKDVITPGDIIKTRQDTTPFRKLTDEEYKNSRVRDFSKTKIEAIFVFADSRDWAGDQQIILDVLMSKNGHLDTRSDSFDEGPPVYFSHNDVVWSTSHEHVRIGMGALRASLEALYKAVTGKELNTIAFGKPQLGTYQFATRLLRQWRKNTHAINKPPSTVYFVGDTPESDIRGTNEFNETSDADWFSILVKTGVYQEGTIPRYPPKKTCNHILDAVKFAIDREMAKEKKDGSALVDDVDSELELEAGLLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSE6</accession>
    <name>A0A8G1VSE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_416430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518635.1">
        <property type="nucleotide sequence ID" value="XM_025657731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSE6"/>
    <dbReference type="GeneID" id="37161133"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF4">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="134"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="468" mass="52401" checksum="09D5989F5B9C31D3" modified="2022-01-19" version="1">MLCIDHNGDLRIEASPSIAGCEKAIFTDDVQDRFLKSVTTAWQSSLQSLHSNTLSHMSGDVTGKPMLLSSPSIGLQHTWYQPSLPRQTGLIPCEWQSLQNKRHRRSLRHELSGIGLDLDSASPTPSLRRTALRLGQTDLVRRYYEKAFEAFQQLNCRVIAKAFVKLVEPRKQVNHPYNGRRAAGGSSQKMDSELTKPKWWPTGVTHKEPDHLQKAERIRLLVHILCELKESRGITAEKLKDAGQDVRRQIQPESRLQVLDEIYYVRYMEELYMEGKISGDTMIYVSHVHLDEDFLFAESRDQTTNNSRELSLPIMNNKPDAPKATEGSKSPGDQSEVQAATDKSHTDMPVPSDERRLPPMEVNHQTKRSANQDYCYPPSPVSSPSISRKSSLESGLSTYSTDMAAPMLSGSEPNGGSCASRDIHTTEASCMPDYFGSQQMATSCAEQSHQPGFWSLPPAHTALPYNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VTK7</accession>
    <name>A0A8G1VTK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_363845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519835.1">
        <property type="nucleotide sequence ID" value="XM_025655675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VTK7"/>
    <dbReference type="GeneID" id="37159077"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000132">
        <property type="entry name" value="FMN dependent dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF75">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_4G07050)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="32"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="111"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="337"/>
            <end position="341"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="360"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH61913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="421" mass="46746" checksum="31EDB0730CA81678" modified="2022-01-19" version="1">MSDPTNPNIEKRTTPQWALYQRENFWKVNDGQTVPFNTDPRKLEEEAHKKLSQGGWFYASSNAGMSNTHLANRQAFFRHRIIPNQLVDTNQRDTTTEIFGHKVSAPIGFAPIGINKIYHPSAELAVAKVAGELNLPYCLSTAGSTPIEKVGEANGQGNPRFFQLYMPHDDELTLSLLNRAWKSGFDALILTTDTWQLGWRHDDVANSNYAFYRGIGADLGLTDPVFQKRCREAGIDPEKDVVAASAKWIDSVWHGRAWSWEKIPWLIERWKEISGGRPFAIKGIQSVADAKKCVEYGVDGIVVSNHAGRQVDGAIASLDALENIANAVGDQIYIMFDSGVRGGSDVAKALALGARFVFVGRLWIWGLSIMGEEGVRHVMKSLLADFDILMAVGGYNSVKDFDKSILESYPKSYALIPDKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VUC4</accession>
    <name>A0A8G1VUC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Aromatic amino acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_494011</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520630.1">
        <property type="nucleotide sequence ID" value="XM_025663851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VUC4"/>
    <dbReference type="GeneID" id="37167253"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23822">
        <property type="entry name" value="RWD_ScYIH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF1">
        <property type="entry name" value="AROMATIC AMINO ACID AMINOTRANSFERASE, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RWD" evidence="12">
        <location>
            <begin position="636"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="652"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="764"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="652"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="764"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH62708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="968" mass="106282" checksum="52C4FA74E5B215C5" modified="2022-01-19" version="1">MVYSTLSPPLDLSHHFSSVTKRREASETKSLYKYFFIPGIANLAGGLPNASYFPYDTLEATVAHPRRFPATSDKDQVKPPSGSPSTERRIVPKESPTTNLLKKIDLTTALQYGTAEGLPVMADFVRQFTRNHLHPNVPYAGGPNTLLTCGATDGFSKAIETFTNPWDPRRDWISQREGILCEEFVYMNAIQTVKPRGLNIVPVAIDAQGMLAHGKGGLADVLENWDFRKGRLPHLMYTITIGQNPTGGTLSVERRREIYALCRQFDIIIIEDDPYWNLQYPSATAMEAGFRGSDAVDVIPRNYNAHGRSSGYDFLDSLVPSYLSVDTDGRVVRLDTFSKTIAPGCRLGWITAQPAVIERLTRLTETSTQQPSGFVQAMVAELIVGQQSEDGQNAAGASKNKSRKSEQAWQMDGWVRWLEGLRAGYEQRMQTMCTILEEGKYLIDSDSAWDDAPQPMADDENAWEVLDKMQMYEFSWPTGGMFVWVKVCIETHPLLEKYGSERLIQALWLHLMQKPYLCLSGPGTMFAPTQELLGRAQGYYRLCFAAMPAEDVSGITRRLVDGFRAFWQRKNLDGLDDEEVALKITVIVLAQCAIILKPRGIKPPITTAAAPGCPAFTKSAKMDPALESLQNTDLAEEIEAINAIYEPDTLTITNTSTSTSTGPSTLDLGGPGSSESSPPSITIKLQLPEHPHLSFLLGFDSTYPDTPPKILGTASTASRGEGKLAVDVLEDILSRTYQPGAVCLFDLINEAVQAFTELNIGGSATATTNNHDTTSHTQPASEETTTESDNYQSLTTGSNTPDYHKFNLTSPPPWILSDVITEKKSVFVGRAAYVTSLDQAKAFLDHLLATEKKVASATHNISAWRIREVKSSTSTAGGSGNKNGEATEMIVQDCDDDGETAAGGRLLHLMQLMDVWDVVVVVTRWYGGVLLGPDRFRIINAAGRDALVKGGFVKEKTSGEKGKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQI3</accession>
    <name>A0A8G1QQI3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mis18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_464477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825093">
        <property type="protein sequence ID" value="RAH51798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509720.1">
        <property type="nucleotide sequence ID" value="XM_025661985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQI3"/>
    <dbReference type="GeneID" id="37165387"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="220"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH51798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="65666" checksum="8F8E0946DFA3B71B" modified="2022-01-19" version="1">MDLSRLTRPAILCQCSRCSSSLAALENEWAKLSNSYSIVAGWLSVELHRISISSEKKQIPQSSELSTLRGRILQEISCKLCQQKLGVLCSLDNGPNIFWKLSKVSFREIVTMRTVEPVFKDGSLERILCPTPPSRQDRTPVHAGALVPTTSTELDPYNLSMEQQIQHQGLSLDHITSSVSNLHDTMSELKNAFTALRIELNGPGRFTSDMGTPASKDMMIATVLKELRSKADEIERLKLENEALKLKNRYAEEQTLKQAQPPPPPPLYADTTILAEVRSPGLLQGSRKRPWPDSFPSGRTQPIGDSFDEDSSDSIADFSLEDASLPPVKIPLKDSTSMSTTDKTTHEPTPSGSPKLHIESNSQRQQQQQQQTPNHDNDLNNHHDNNSATSHREAIVKRPRLSQSTDKPTTSGRRPGRPPRKSFSQTAKPDITTTTTTTTTTNNQSPKSTPLTEQNGNAHKDSQFDESSPSDTRTTKENRPAHSRSLRSRSRPPSRRQSAAANADSRSLEPEQTAQNGYQNGDDVPDHTEQRQQQQQPIPPLHTGKENSHGGANGVHKPDSREKRKAQSAARDIMVRLAMQREEAMETEDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS89</accession>
    <name>A0A8G1QS89_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2OG-Fe(II) oxygenase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_453802</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510605.1">
        <property type="nucleotide sequence ID" value="XM_025661135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QS89"/>
    <dbReference type="GeneID" id="37164537"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF881">
        <property type="entry name" value="FI07970P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="209"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="360" mass="40344" checksum="CCECE066EA69A6CF" modified="2022-01-19" version="1">MTAMATPQYTHVELLTLNGPEYRRVSTAPPRLPSDDEIPVIDLVGIDGDLDARTVLAGKIRAAAQNTGFFYIKNHGIAEEMIAGALTQAKAFFHQPQEEKEKVSNFKLMHMDGYHAVGTTQVNKSETKDRKETFSLRYNGRNDPAMGPDTPDDRIWDDSALWAGTAHLPNFRETTISFWQARLALARKMVRIFALALDLPEDYFDSVVTHPGADGLYIHYPGTPEAELKDDKIDVGIGSHTDIQCFTLLWQDMSGGLQVLSSSDEWLDARPIPGTLVVNIGDFLQRLSNKRFRSTVHRVYNRQSTSRYSMPFFFGFNPETVCQVVPSCVDEQHPALFEPISCGKWHRDRLALAQGKLATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSR0</accession>
    <name>A0A8G1QSR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_214629</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509821.1">
        <property type="nucleotide sequence ID" value="XM_025654636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSR0"/>
    <dbReference type="GeneID" id="37158038"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000018">
        <property type="entry name" value="Cell division cycle protein 27 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="516"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="584"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="618"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="652"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="754"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="258"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH51899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="809" mass="89608" checksum="EFB3AE3F052F1B30" modified="2022-01-19" version="1">MSPSTAHISSQLRQLIYYHLDNNLVRNALFLAGRLHAYEPRAAESSYLLALCHLQSGQVKAAYDYSKNFGWRGTHLGCAYVFAQACLDLGKYPEGITALERSKGLWSTKNHWGKHSETRRQHLPDAAAVLCLQGKLFYAHNELNAAVECYVDALKLNPFMWDAFLGLCETGVNIRVPNIFKMTPELSALLASSSQDDLDVSSDKAAHPAGPLQSQPKLNSSTDPFTSLTSRTEAVGTHGSSALWEKLNGSTVSVASTGTSAVPAIREGTETPGGQSSESDDRVMHRTDAPLEPPLAPARKNRTIQTISADHGMDSPPKMKPTGIRPRTRTKPEPDESTTTYTERELSHGVRVGDRKRTVSGSVAHSAQQPTEPGAPQRRSVRLFNQIKPTTSKLSSTALGTKDGREMKKVRATGAKGRTTTAPSVGRVVSGNRKHIGDTHDGEAKDHRPATSASNGTHHTSSRGPSLDRSKAVEALTWLLELFSKLASGYFALCRYRCAEATQIFAALSQGQRETPWVLSQIGRAYYEQAMYSEAEKYFVRVKSMAPSRLEDMEIYSTVLWHLKNDVELAYLAHELMETDRLSPQAWCAVGNSFSHQRDHDQALKCFKRATQLDPHFAYGFTLQGHEYVANEEYDKALDAYRHGISADSRHYNAWYGLGTVYDKMGKLEFAEQHFRNAANINPTNAVLICCIGLVLEKMNNPRGALAQYGRACQLAPHSVLARFRKARVLMKLSELKLALTELKVLKDMAPDEANVHYLLGKLYKMLHEKANAIKHFTTALNLDPKAAQYIKDAMESLDDDEEDDEDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTL2</accession>
    <name>A0A8G1QTL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_407695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510509.1">
        <property type="nucleotide sequence ID" value="XM_025657371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTL2"/>
    <dbReference type="GeneID" id="37160773"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018279">
        <property type="entry name" value="Ribosomal_eS21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00996">
        <property type="entry name" value="RIBOSOMAL_S21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH52587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="88" mass="9998" checksum="16E528D6CA4AFF18" modified="2022-01-19" version="1">MENEKGEIVDLYVPRKCSATNRIIKANDHASVQISIAKVDENGRYTGENHTYALCGFIRARGESDDSLNRLAQRDGYIRNVWTAARQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUD6</accession>
    <name>A0A8G1QUD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_452675</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-50 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511760.1">
        <property type="nucleotide sequence ID" value="XM_025660881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUD6"/>
    <dbReference type="GeneID" id="37164283"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007881">
        <property type="entry name" value="UNC-50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841:SF6">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH53838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="286" mass="32000" checksum="D32703425E4FB613" modified="2022-01-19" version="1">MNPHISVPRQHASPASFGGTTPASRGSSIRMPRFFKRLFKFPQMDFEMAIWEMTSLLIAPKKVFKSIYYHKQTKNTWHRPDPSFTYLLSFFLLLTALAWGLAYAPSFGSIVRLSLIFIFVHFIGSSLLVSTVGYFAIPRLFGPDGAAASLTGFRGGRGRRRGAAQGLFTQPGEKDQLEFGYCFDVSNRAFFPLYLHLYVVQFLVLPLLQRSSNALATFLGNTLYLSAVTYYTYITFLGYNALPFLHNTELLLLPILALAVLWLVSLICGWGIVAQGHGVEGLFWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUF5</accession>
    <name>A0A8G1QUF5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_205034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825085">
        <property type="protein sequence ID" value="RAH52410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510332.1">
        <property type="nucleotide sequence ID" value="XM_025654567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUF5"/>
    <dbReference type="GeneID" id="37157969"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF2">
        <property type="entry name" value="HYPOTHETICAL POLYSACCHARIDE DEACETYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="277"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="546" mass="60745" checksum="4DC6B9AD4AE2FFEF" modified="2022-01-19" version="1">MPPSFLGLEGLHVFVAGAAGDIGRRAVQEFLDQGCKVTAFDLHNVEIPEANRNDVHPRLHILKGDDTKEESIQSCISQASQRLGPISVLVVNSITSGQGNDLPIWDLALDTWERTSRANLRGTFLTIKHFLRAAQTAQQSAGKQLENLAIVVAGGETPVQAKLYTELAQRVKNDIVRLNSQARINIIAPVEPAAGTQADSIPRTIAFLSSHRAAGHLTGQCLNLSNNTQSESTSTSLTPSIPRSLTRVSKKIRVAISIDLDAVSGWLGTGKSPDNILADYSAGFFGAKVGVPRLLNMLKKLNLADRCTWFVPGHSAESFPDEVQQVVDSGCEIALHGYAHEGAYQMTPEQERDVLVKCIEIAKKLTGKKPVGYRAPLYQLRESTLDLLEEFGFEYDSSITEHDSYPIFAPRRPAIEPIDFSKPAASWMKPLPASSDRRPLVCVPCNWYMEDMTPMQFLPHVPNSHGYTDARVMENMWKDRFLWIRENEEEPLFPILMHPDTSGMVHVIGMQERFLNWLKSWGDEVEFCQTVEVAKWFREKEMGKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUR4</accession>
    <name>A0A8G1QUR4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_463045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511263.1">
        <property type="nucleotide sequence ID" value="XM_025661895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUR4"/>
    <dbReference type="GeneID" id="37165297"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="119" mass="12349" checksum="4C05EB2E058B5827" modified="2022-01-19" version="1">MGEAAAAAASGIKLVWTGRVVVGAGLGKTAAGFADESHGWRSDTVQVAVIGGGFHDLDDHPDKQNIHIYSEGDFDQVSDQVSGPSGQAPTNLPQSLFSPSSQHPSETSKTTAHCTFPMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUT1</accession>
    <name>A0A8G1QUT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_502538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511955.1">
        <property type="nucleotide sequence ID" value="XM_025664197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUT1"/>
    <dbReference type="GeneID" id="37167599"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="29"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH54033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="232" mass="25625" checksum="36EB121FECF5E6B5" modified="2022-01-19" version="1">MSRPKRILHVVTNVGHYDDPSHPTGLWLTELTHAWDVFDASGYTQTIVSPAGGHCPLEPRSLKFPNVDRTAKTWQADVERMALLQNTFSPEQIKSADFDAIYFTGGHGVMYDFKDSEGLQRITREIFERGGVVASVCHGCCGLLNTTLSDGSYLVAGRKLTGFSWREELLARVNKLVPYNVEEELKKRGARYMKATLPFTSYAVNDGNLVTGQNPGSAKETAKKVVKVLSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUX8</accession>
    <name>A0A8G1QUX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pfs domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_442949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510587.1">
        <property type="nucleotide sequence ID" value="XM_025658861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUX8"/>
    <dbReference type="GeneID" id="37162263"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="313" mass="34345" checksum="85686BF683966E68" modified="2022-01-19" version="1">MSPPLPDLTHDDYTIACICPMGVELAAVEGMMDEQHPNLPSSIDKNTYTFGRMGAHNIVVAVMPEAGNDRAAAVATQLSNDFQSIKFSLLIGVGGGIPDLARDIDIRLGDVVVSRPSNRFGGVVQFDRGKDHSYNQFERTGMLQKPPDILLSTVQRLEALHARVDSRIPVFLEEMLARFPKMRKRNYVYQGATKDQLFQIEYEHIGATDCGDCDSSQTVEREVRDDSTPVIHYGTIGSSNVVIRDSVKREILKADLGILCVEMEAAGLINNFPCLVIRGICDYADSHKNKAWQPYAAATAAGHLYVTGEDTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVB0</accession>
    <name>A0A8G1QVB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_471121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512246.1">
        <property type="nucleotide sequence ID" value="XM_025662447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVB0"/>
    <dbReference type="GeneID" id="37165849"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="191" mass="22666" checksum="48A8799B929259E7" modified="2022-01-19" version="1">MPPITRAQAKHKFPDFLPEASRTGATYQDLSDPVTRLFQPIFEQWDYRYYLTLRRSCPVERPQTEWLMLVQVSLINLSQTLGAAFDEGVFQTQYVGPIEYYKFMAVYFPEDLAGTHIKELNRTNPFNLGNLIGSDHGWLDQPVFYQGQHTLYLIYFLRWENSDREHEYKNFCVTINGKIIDYWKEFMTPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVM5</accession>
    <name>A0A8G1QVM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobic surface binding protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_491113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512314.1">
        <property type="nucleotide sequence ID" value="XM_025663693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVM5"/>
    <dbReference type="GeneID" id="37167095"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF1">
        <property type="entry name" value="HYDROPHOBIC SURFACE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034384572" description="Hydrophobic surface binding protein A" evidence="1">
        <location>
            <begin position="19"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="17769" checksum="B9FDCBF3DF7F26D1" modified="2022-01-19" version="1">MICNSFLVVAFGLGLAQAGPIAKRDAATVLSDLETIGTDVTTLKTDVTNWTGDLLAALGILSDYNTVKSALETAITDTEAASAFTTSESSSITSEVTSLATIIIATLDELISKESTAASAGVTSTLLSSLETLKTDTDELGADLEAKATTTDASTIASTLASIDAAFSSAIAAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVQ9</accession>
    <name>A0A8G1QVQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_404033</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512471.1">
        <property type="nucleotide sequence ID" value="XM_025657256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVQ9"/>
    <dbReference type="GeneID" id="37160658"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF23">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="5">
        <location>
            <begin position="226"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH54549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="711" mass="79206" checksum="786A1299CC7744BC" modified="2022-01-19" version="1">MVVAETNPKDDECKGLLTSISCTPASPPPSSSPPPPPSSDDVKLELGYYSYEDEKRPGVLSEEPEKQIGSIGLLVWMTINIVATVAIVFTNKSILSNASFRNSQVSFAAYHFTITGLTLWLASRPFCGWFEPKHVSPYRILHLVAAMCIQVIFQNLALAYSSVIFHQLARLLLTPATALLNFVLFQSSIPRSAFLPLVLLCTGVGIVSYFDSLPSAKGNDTTTPEGIFFALSGVCASALYTVLVGRYHKKLEMSSMQLLLNQAPVSAAVLLCVVPWMETFPEVATVPGSLWTSILASGIFACLVNLSQFYIIDAAGPVTSTVIGQLKTCIIVGLGWVLSDHEILRQSVAGILMALTGMSFRRRFQLSFALAIVLLLSYLFHLDVLPTDYEAPFKDHYARTLSARDLLARPLSQDLTTIPKLIHQTWFPAGSNMSDDAQTWVRTMRSQNADWEYVLWDDETNRMLVEQYFPWFLTDYNRLPKEIHRADVVRNLYMYLFGGMYADVDTEALRPVEPLFTSHSTNLAKHSQILSSGPRKNDHECTQRGFVGHMAHKEGLDGPAAVPNGWMASPPGHPFWLLPVIHVIENPNGNGDGSVESLTGPGALGTMLHKYYEDFKDSSVRTHVCRTVRRWSPAWDLYCGPEGSEDEVGAKADKMVVLPRQQIYPYSWADDKHPACLAAWGNPDFNPDECKRWIDVDEWPSYFITYCTHSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVZ8</accession>
    <name>A0A8G1QVZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial tricarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_144205</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511784.1">
        <property type="nucleotide sequence ID" value="XM_025654097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVZ8"/>
    <dbReference type="GeneID" id="37157499"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000092">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000064">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter (Ctp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="12"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="102"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="199"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH53862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="296" mass="32459" checksum="6AEEC78510A45CF9" modified="2022-01-19" version="1">MATSENDKRPKPSSLRSIIAGSTAGAIEIAITYPAEFAKTRSQLNRRLPDAKKLPWPPFGAQWYAGCTTLIIGNSLKAGIRFVAFDWLKSLLQDENGKISGPRTVIAGFGAGFTESLLAVTPFESIKTQLIDDRKSQNPRMRGFLHGSKVIFQERGVRGFFQGFVPTTARQAANSAVRFSSYTMLKQLAQGYVAPGEKLGTASTFALGGIAGLITVYVTQPLDTVKTRMQSLEASKNYKNSFVCAARIFKDEGIFTFWSGAVPRLARLIMSGGIVFTMYEKTMDALDGLDPERRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWC7</accession>
    <name>A0A8G1QWC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 20">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="15">IMP dehydrogenase</shortName>
            <shortName evidence="15">IMPD</shortName>
            <shortName evidence="15">IMPDH</shortName>
            <ecNumber evidence="15 20">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BO85DRAFT_453907</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world. Does not play a role in the biosynthesis of MPA, but is involved in self resistance to MPA, since MPA acts as an inhibitor of IMP dehydrogenases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15 20">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15 20">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15 19">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="15 20"/>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510507.1">
        <property type="nucleotide sequence ID" value="XM_025661157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWC7"/>
    <dbReference type="GeneID" id="37164559"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15 20" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 15 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 15 17" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 15 20" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="134"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="197"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="15">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15 16">
        <location>
            <begin position="291"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16">
        <location>
            <begin position="341"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 17">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 17">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 17">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="381"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="404"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="429"/>
            <end position="433"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RAH52585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="545" mass="57973" checksum="5FC7584863738E11" modified="2022-01-19" version="1">MPISNGDSLGRAMQAEIQDHTKALEVLKTYTTQDGLDVDTLLDSDKHGALTYNDFLILPGYIGFPASDVTLDTPVTKRVSLKVPLLSSPMDTVTEHNMAIHMALLGGLGVIHHNCAPEEQAEMVRKVKRYENGFISDPVVLSPKATVREAKELKAKWGFGGFPVTENGTLRSKLVGIVTSRDIQFHRDLDDSVTAIMSTDLITAPAGTTLAEANEVLRSSKKGKLPIVDENGHLVSLLSRSDLMKNLHYPLASKLPQSKQLIAAAAIGTREQDKTRLKLLVDAGLDIVILDSSQGNSMYQIEMIKWIKQNFPEIDVIGGNVVTREQAAALIAAGVDGLRIGMGSGSACITQEVMAVGRPQAIAVRSVTAFAARFGVPCIADGGVQNVGHIVKGLAMGASTVMMGGLLAGTTESPGEYFMSKEGQLVKSYRGMGSIAAMEDKKAGAGSKDSKASNAGTARYFSEKDGVLVAQGVAGSVLDRGSVTKFVPYLVAGVQHSLQDIGVPSLKALHEGVNNGTVRFEMRSASAMAEGNVHGLHSYDKKLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWF7</accession>
    <name>A0A8G1QWF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="14">PAGM</shortName>
            <ecNumber evidence="4 14">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 14">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BO85DRAFT_402670</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14 17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 14"/>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512846.1">
        <property type="nucleotide sequence ID" value="XM_025657196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWF7"/>
    <dbReference type="GeneID" id="37160598"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000013">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000023">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 14 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="123"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="21">
        <location>
            <begin position="187"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="20">
        <location>
            <begin position="307"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="18">
        <location>
            <begin position="462"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="15">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="17">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="382"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="507"/>
            <end position="511"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RAH54924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="551" mass="59989" checksum="431715F2C3E7B5FF" modified="2022-01-19" version="1">MASPAIRKAIAEAASQYSKPEGKVFQYGTAGFRMKADLLNTVVFTVGLLAGLRSRKLSGQWVGVMVTASHNPAEDNGVKLIDPMGEMLEAEWETYATRLANAPLDKVGDVFDELIKEIDVSMENPARVVFARDTRASGSRLVSVINAALTASEVEFSDLKYMTTPQLHYVVRCKNTLGTQYEYGEPTEQGYYEKLAEAFKRVMRGVKVKGSLTVDCANGVGGPKLRELIKYLPGPEEGGMDIKIVNDDVINPDSLNFECGADYVKTKQRAPPSSKAAALDRCASLDGDADRIVYYFIDESNTFRLLDGDRIATLAASFIGDLARSAGIAQKLKIGVVQTAYANGSSTDYIEKVLKLPSVCTNTGVKHLHHAALRFDVGVYFEANGHGTITFSETALKTIKNTEPQSPAQQRSLECLQALTDLINQAVGDAISDMLLVEAILAHKGWSPKEWLATYTDLPSRLVRVEVADRSIFKAYDAERKLESPPGLQAKIESLQSRYNKGRSFARASGTEDAVRVYAEAASRSEADDLATRVANAVREAGTAKETLQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX53</accession>
    <name>A0A8G1QX53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_491213</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512414.1">
        <property type="nucleotide sequence ID" value="XM_025663702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX53"/>
    <dbReference type="GeneID" id="37167104"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF40">
        <property type="entry name" value="THIAMINE PATHWAY TRANSPORTER THI73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="33"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH54492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="478" mass="52037" checksum="5130547B6D32AF6B" modified="2022-01-19" version="1">MSDTKEEKLATIDYGLGDLHDDSALLRRIDWRILPIMFLTYFLQFLDKVALNYANVMGMQDDLGMKGNDFSWLATGFFIAYAVAEIPQGFLLQRYPITKVLGFNILCWGVLLCCSAAAQNFAGMMSLRVLLGTLEAVIAPALTMYTSMWYTRAESTPRYGLWYCGLGTGQIIGGLISFAAQHAPASMSFHGWRIMFVVIGAVNVLVALLVLFILPATLSEARFLSTSEKVRVEERLRQDQAGVGEKVFRAISLLEAFADLQTALLVLLTILITIPSGVITTFSSILIKDFGYDSKESALLNMPSGVVSIVATMASTMAIARGYSRWLAINVLLIPTLLGACLMSFLPSSNQGGCLAGIYLVNTTVAPLALIFAWTGANYKGYTMKVAGSTLVSAGFSIANVIGPQTFQSRDAPGYIPAKITIVAVNAGAIIISTMLRVVYGRRNARANRLGRAAGSRMEERLRSEGDDEGVVDFRYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXJ3</accession>
    <name>A0A8G1QXJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_471631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511907.1">
        <property type="nucleotide sequence ID" value="XM_025662486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXJ3"/>
    <dbReference type="GeneID" id="37165888"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="93"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="347" mass="39570" checksum="8074215DC2CF4A1B" modified="2022-01-19" version="1">MILSVIRTWLYDVIWHPVATESDESKNIAPLQINTPNHCQIDEMEAGLSPHVQSLRAEGQNHNPQPRTGKIECTHIPGRSSNTLPSPFSRDPYLGLPVIGNGMTGFILKLGEDRAVKKAKRYQPGYLQNREDVEYMNQINQQTLDNEMQVFQRLGSHKGIISCFPTSQYGIELALAQENLETYLETHPEHDNSLKTSWIWSIINTFTHVHSCKVFVDDIALRNILVVDGQLKLSDFGQSILLPHDTDMTSANENDLNVQIEILHLGWVLYSIASWRVHKYYFFSPGNPGLCWPEPDSFPNVDHVLFGRIIQKCWRGEYTSMDNLRDEAHQLLTADEDHPVRDLGNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXS9</accession>
    <name>A0A8G1QXS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_67960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513780.1">
        <property type="nucleotide sequence ID" value="XM_025665586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXS9"/>
    <dbReference type="GeneID" id="37168988"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="160" mass="17974" checksum="EE115940AE1071B3" modified="2022-01-19" version="1">MRCLAENAGTTTHASRSHPAMEPIILFGLITASNAWNFIFSSIQKMLFFFSILLSTYTFLGIFSPVSQSLPSILLPFQHHPYYSIRILPLLLVAKPPGITSSQPLTHDASCWGMNLLQNQSLLCGKWNYLIMGTREVHVVSSNHMNQFPIKPKRGTKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXV7</accession>
    <name>A0A8G1QXV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_423253</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514333.1">
        <property type="nucleotide sequence ID" value="XM_025658007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXV7"/>
    <dbReference type="GeneID" id="37161409"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="544"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="128"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH56411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="645" mass="73192" checksum="6F71F7CF67D4CD53" modified="2022-01-19" version="1">MPPRESVVDNPKSPLRRCHHYIYIISWALLSSLILYCAGGISYVDALLLASGAATQTGLNTVDLNRLHVVRQVTLLVVSMVTNVIFVHSLLVVIRLYWFRKRFKRAINEAKMMCRAQRNTLNQRLADVENGPSRSFSRERPAEDTPLLSTVTEESLTVSPSESPGGRRYGATGSMSPHITFCETDAEHEVKQRRRTYSGTWSRRSFPEIDSPQRRRSFSEMQNDMPPLPSLMWQSSIASYSDWNEAQKEELGGIEYRALKTLFIILVCYYVVIHLLGALLFLVWILPNKHYGQILADNGLSRPWWAIFTAGSAFNDLGFTLTPNSMGSFNTAVFPLLVMTFLIVLGNTGFPCMLRFIIWILSQFTTYGSPLDDELQFLLDHPRRCFTLLFPSTETWRLAAVLLLINAIDLIIFYTLQEFPHPSPISAGLRLVNGLFQIASTRTAGFTIASLGTLHPAVQVSFVGMMYISAFPIAIAMRKTNVYEERSLGIYNEEYDEHDKPHQSDSLGAHIQRQLGFDLWFVMLGFFFVAVAEGKRLQENRTDIAFSLFPILFEIVSAYGTVGLSMGYPGTETSLCREFNGLSKVIVIAMQVRGRHRGLPHALDHAILLPCDLVEPDEQGRRPEWWWKRWIRKKSSDLGNLFTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYD0</accession>
    <name>A0A8G1QYD0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_379025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512342.1">
        <property type="nucleotide sequence ID" value="XM_025656322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYD0"/>
    <dbReference type="GeneID" id="37159724"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH54420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="285" mass="31108" checksum="2867CD9ABD3D2FC9" modified="2022-01-19" version="1">MSPTSTDTASAAEAKNGTSTPFVNTMPDSTFSWQITLAQKVIAITGANRGIGLGIAEVCLANSAKFVYSMDLMEPGEETIALQTRYPNFRYIQTDVTSEESIEKAVNQIVEETGRIDGLVANAGMTKHQPALKFERPELERMFNLNVFGAYFCAQIVARKFIELGIKGSIVMTASMTSYRPNRAAPSAPYGATKAAVRNMCHTLAMEWSKHGIRVNSISPGFVRTAMTYYVETAPDWDTKMEYYGGMPRLADPRELGGAYVYLLSDSSSYTTGIDIPIAGIVGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYF7</accession>
    <name>A0A8G1QYF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_490569</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512836.1">
        <property type="nucleotide sequence ID" value="XM_025663666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYF7"/>
    <dbReference type="GeneID" id="37167068"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000116">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="311"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="503"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="765"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="251"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="366"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="855"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="865"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH54914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="901" mass="99154" checksum="207327D1F6AF0A34" modified="2022-01-19" version="1">MADSCASNGTQEDDNQDQIGSNSPTPTGISTPQPDLADKRLPSINSSYFQVGSPSGDKSRSSNTWSSETSTSAQNPQSDAAPTGTRDRGSSPSGSFVMMERPEASDTQSSTASTDQSLETHTLQPETLPPTNLPTPPYSSACSLLQKESDEAELGSSAPDKGMGSIFNTLKNYLSPSGSMSSPEQTSRRHTSLPVSSVSDDPVLASHFSNPSLLPASDAFCLPDAPLLEHEKPHVSMSSENLAKLTGTVSDLVRLKSTPPLTPRAMSNEGSQTDKKPPTSSPHPSEPAQPPSDESANAADEIAGKLNEAFPPERDTPSPTGPPVASLKGKLYVNISEARGLRPGFDPYVVCVFEWNEVISKSAQDEEAATLERQQKEQEKSDREAGRPMAIPMKSRQSSNNSALDGEPRGRAPVTDPHWNHEAVFDVFGDQSEVDVSVYDRKDQEAFLGHVRLCINLKDDNSRLEGWFPLKSRGAGDSQVSGEIHMEMRFERTEKKQVGPNDFQILKLIGKGTFGQVYQVKKKDTRRIYAMKVLSKKVIIQKKEVAHTLGERNILVRTAMAASPFIVGLKFSFQTPTDLYLVTDYMSGGELFWHLQKEGRFQEARAKFYIAELILALQHLHDHDIVYRDLKPENILLDANGHIALCDFGLSKANLTQNDTTNTFCGTTEYLAPEVLLDEQGYTKMVDFWSLGVLVFEMCCGWSPFYAEDTQQMYKNIAFGKVRFPRDALSTEGRNFVKGLLNRNPKHRLGAKGDAKELMAHPFFDDVDWQALGRKEVIPPFKPTLKSDTDTSNFDPEFTNALETNNSLNDRAAAIANGFMPASTPLSPGLQANFKGFTFVNESSMDHHFTNEPGDHMEEDAETWQRPQQPASTANHRMSGVQRTHEGGEPGIFNVDDNFDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYK8</accession>
    <name>A0A8G1QYK8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_470579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513164.1">
        <property type="nucleotide sequence ID" value="XM_025662410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYK8"/>
    <dbReference type="GeneID" id="37165812"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="253" mass="27421" checksum="2DAF077AE4EF0EA5" modified="2022-01-19" version="1">MSFRPMLKQRAVAPIAATLLAGGIALYPRQTAFAEEPRDAKKPIYDDFPTEIPAVSKPVVSPAPTTTTPAAPVSTPFSSPSSPTPTDILTAQVRQARLFLYENSLAVETKFNNFLSRALHIENAFTNTVASLAPSPESGERLLPGGVYVVVAAMAGSIVSRNRGILLRTASPLAFGTVAAWTLLPVTMRNVSDLVWEYEKQVPAVADTHLQVREKAEHLWYTGIAHSGMARAMMEEKIGDVRKKLEEVVSKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYR2</accession>
    <name>A0A8G1QYR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aerobactin siderophore biosynthesis IucA/IucC N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_471749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511692.1">
        <property type="nucleotide sequence ID" value="XM_025662501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYR2"/>
    <dbReference type="GeneID" id="37165903"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="IucA/IucC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="L-2,3-DIAMINOPROPANOATE--CITRATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384:SF5">
        <property type="entry name" value="L-2,3-DIAMINOPROPANOATE--CITRATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aerobactin siderophore biosynthesis IucA/IucC N-terminal" evidence="1">
        <location>
            <begin position="287"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal" evidence="2">
        <location>
            <begin position="427"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="68919" checksum="D9EC67578C568EF6" modified="2022-01-19" version="1">MPANLREGSTTMQTTEWKEFVVRNSTGCKVTTHITETADHETNTSLNRQQALFETTKRVLATGNGESWIKCGLRNSAYVENNGGEITGFLRADDLLPPVLTQTVEGEISEELDPGAICRIICLWQREHFTNAAVETLVKEVRNSTDNQAKWLEIASNQPTLHLKSPLCDWEQSVVLGHPTHPVSFPDTILDPDCRSVNAVKLHRACLAQPPLKPITPDEIPELLEPELSFLSLPRSEMKTFGPYTSLLKPLLGQLGISSPDSPDRVVVPCFTRQLPSILPLFPDAHHIGAVRRCCRAQISMRTISFLPDVGSPLHLKLSLNCQITSGPRTITPWTAALSPALSTALRTLLPQDLWIFEDAASITGGQDDFDKARHLTCIIRKSPEMQAEELGETIIPVAGLFQKPYKDNRTYMEIMFGLDDLRKKQTWLRKYLAKLFSLLLPPLVRYGIGLEAHAQNICVRINTTSKEVTGFAVRDFGGARIHRPTFFRTRIELSTIPPGASAFVEDMHKVWHKVYHALIQMHVGHLLYMLGLESHGGWPIVREELKRVLVSSCDPEAKAVHDAFMNKTMAFKCFMEMRLRNIYRDYYERELPNVLLRDMQSEDDPASKTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZE0</accession>
    <name>A0A8G1QZE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylsulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_425547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513599.1">
        <property type="nucleotide sequence ID" value="XM_025658080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZE0"/>
    <dbReference type="GeneID" id="37161482"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF8">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034953959" evidence="2">
        <location>
            <begin position="17"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="621" mass="69681" checksum="3343535BAD3352F3" modified="2022-01-19" version="1">MIWCLFALLFLQFTFAQRHDEDLMSFVTLPEVRALKWEITHHDRDRAAPGYWFVAPYGMIDPESPTRKYLQYQVGPYIYDQDGVLIWAGSPMFDNRNTFDFKAVHNIDDKPHLSLIAQRTFDETVLGSGLILSQHYEVESEVFKLNDTWEFNVHEFKVMDGGKTALACVYQSKMLDMADVGRPGEQKLFLTGGFAELDLATGAPLFEWDSSDHLGLHETDRFHTWEEPMGPWGFDSVHMNAVDKNEAGDYIISMRFTDTIYMISGVDGRVMWRLGGRETNFVQDFVFSKQHDVKFVSSNGTHHIISFLNNASDEITTDETISSALFVELDTTANPMTARLIARYNRPDGQLSRLRGNTQLLPNGNVFVGWSQSGYQSEFSPEGKVLMTARFASDRFSTYRAYKYEFTGRPRAPPDLVASVYGTTEDDLTTIVHVSWNGATDVAAWNFYAQAYDGGAPVLIGNVSKTDFETMFIAHGFLDWVSAAAVDHQGNVMGTSAVHRTKAPDNWEAAGFVGSSKAPSPINPSSIYKEAQAGEDHSSALSNGDTKDLLAALSQAYQVVRGLGNLLIFILVVSSFAGVLLGAFWVLRRRRIQRLQPYRHVPSEESFPMEETPLRNNASSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZM0</accession>
    <name>A0A8G1QZM0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rerric reductase like transmembrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_378149</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513002.1">
        <property type="nucleotide sequence ID" value="XM_025656288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZM0"/>
    <dbReference type="GeneID" id="37159690"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
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        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="7">
        <location>
            <begin position="119"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH55080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="291" mass="32871" checksum="3AF73D5D93841148" modified="2022-01-19" version="1">MSFSWPWHFTSLTDAEKQQRRELLDLRGVYAQCSVLIALILVRVYKKSFSEAPGTEKPAERRSRRKNLEKSWLDTPPVAGWMETRRQYIVCLLWLGWLLSLCIWNSGEDYLHFTKALAHVSLSQLPLQVLMSPALYMSPSPGSPSVVSVITSVPQPTINAYHRLFGRIVLAPLLIAHAVMYDSFFLQSSHPDFGSLFAKRIWDSDVQWGIAAATKVGAVALFARPAAMPRWVRWLKPTSAKSRQQVFYLVHVSIVGALELAAFCHVSVARTYILESFASSAINFACCYMMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R070</accession>
    <name>A0A8G1R070_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_450162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514699.1">
        <property type="nucleotide sequence ID" value="XM_025660310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R070"/>
    <dbReference type="GeneID" id="37163712"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="458" mass="52808" checksum="006E7585702C660C" modified="2022-01-19" version="1">MASIKNDEHQHQSSTNDPREVEEKLCQLMKDNLHTTANDPTGAEKQSHQPDCSPPLDDPPTDSSSSPDNDNKTNEEADEPRIQAKEATGLNNDPSPSPNDDNKTDKRADEEADESTAPAKDETKPADDELSESSEDESNSPEPDPSETKADRLRRERRAQLDDYIKRSPKKLMPRDIWQLEQDFRLTDWQACATDPSYQPPVGTELELSEAEAEELQRQEREWWRLEQEDMMSCCLIPDEGWLADLKTEQTSKNEAADESTTPVKEETKPDNHLPQPSENEPDTQLCPSETKADRMRREHRAQLDSYYKLNQGSLLPRGVWQMEQDFRLTDWQAYATDPSYLPPFATRLELSESEAEELRRQERVFWEQKDLPYDRNSRIMPLEYEGIIPNDDWFHDLKAEPMSREEELRRYHEQKSRTKKSKECEDGRNITAVAPNEAENSLASDQIRADPLVPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R087</accession>
    <name>A0A8G1R087_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514790.1">
        <property type="nucleotide sequence ID" value="XM_025660335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R087"/>
    <dbReference type="GeneID" id="37163737"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH56868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="60" mass="7000" checksum="9645A83D71A78A6D" modified="2022-01-19" version="1">MARYETQAITRTEGRDVETRKMDLALVRPLFDRPELPISYPRQIAVQAEAECGTDSYRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R201</accession>
    <name>A0A8G1R201_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_459902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025661683.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="37165085"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22567" checksum="23305DF82B9110B3" modified="2022-01-19" version="1">MIGSIFFICNRILELVFLIPIIGMMAYFVNGYLNANQITPAYILVLFIVSVIAAFWCLDTLIRFSTTKRSAMFVAFIDLLFFGAFIAGVYELRFIAGASCSHWDGGSVYISLGPFGYYGYRTDNPLSFHIDKTCAMLKASFALGIIEVVFFLWTAILALAIYKRPEVVVKETTVRRRSHSSRRGHRRHSSSGRRQQYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R214</accession>
    <name>A0A8G1R214_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_370879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515735.1">
        <property type="nucleotide sequence ID" value="XM_025655976.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37159378"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057334">
        <property type="entry name" value="PH_2nd_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF41">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25353">
        <property type="entry name" value="PH_2nd_LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="148"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1256"/>
            <end position="1266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1293" mass="143074" checksum="7F7C24FE9664A010" modified="2022-01-19" version="1">MAESLGKKERRKSLSVFSPSMTTSSLPAPAAHERSPSDDAQVLKKKSRRNSGFFGVRHPSPPRATPTRGLRRPGTADSESATYVTALPTVALEGPRSRRKSLQKRRTSVFGSLRSLHSQEDDDRSLGRSKGSSLDEDPPELRQGIGSIILHHGEISITGGMWRKKSHYLVLTDTHLVRFKNQSKAADMFPSIPASFTSRSVAANRQSVASISSLQDPQLAAASESISGIALNSIIAVYMLDDGRPSSTVEVAYVDERAQKATFIQMQTPDFQELNLWMVGIRSAAELIRGADPLVFDQKTADCVVRMLEYERDYDPETFRMFRVIQMASSKSPARASSEDLTKLSPTGCYLALGSHKLHLIPLHKISSRSSVVSLSDLDAATSFGLMNLTCLSMEWGDDSLHLTFRVPTRKPFSVFLASVHSVEIAFWIRQQTEFLRPLWIKQPYDFIVPRDLDNESNFPPVSLDEDYGCFDRTLVAYSASYDIDTSNIRYTIDVQCDDAPCFRLLPPASARQKKYTALELIAVLRALRYNESFRSISFSGVSLDVLQGLRDIYGPDKDALLSRAGAPIQIPGQENLSVLSQEVRALTLKSKWLRRLDFSYTLSRIPKSDSESHDPGCGIPEAIFPICRRELTSVDWVVLNGIKLGDSDLDYLVDASSQRSSHMRALEVGNCGLSVHDLDLLLSTVVAQSSTLEAMNISGVQGRLSPDILQQYLGYFTQIKTLDLSRISRTSGTEPLITPETLFNWRLEELSLSRTLVNRETVDAIATYLASDRSRGLRVLRLDQCGLSGQDVAIFLHSMTANGFPRDLHLHVNENRLDQGCSYLFKAIAQNKTPTHMSMRMIDFKKEEQFQELVEALRKNRTLKCLDISKASLPYDAGPETCKALQLMFEENETLEDLDISGESAHLDVARFGIGLNLALTGLKKNKSLRVLRIEHQKLGLQGANTLASVLEDNECLREVYCENNDINLQSFTVLVNGLQRNRSLLSLSFMDRDRVQSLERVRREIRNVKRDVSLAQSSATSSIRRSLHAAMNGKTSSKSSKQQHTSGHRSGASVASSLSATAETSPLLQQDVEVILQSLSRKWDGEVARLRRYLYRNYNLAHGIEDDMAGLDDDTSSDGRPTTAGSLGLMLDHLKLDLPPEIEPTSPKDHLDMFKGLDAESSLVAELRQRPQTAPFSVPGYAPHILPPEYAGSSTSSSRLAVPVPPIPSTVSKSSSVRSARSSSTVSTSTRASARSTYGTASSTLRGFLSGSASKERKKLEKMRSGAVCVSTDRPPKLEWAPPPLDLGKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2A4</accession>
    <name>A0A8G1R2A4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_396697</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515870.1">
        <property type="nucleotide sequence ID" value="XM_025657005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2A4"/>
    <dbReference type="GeneID" id="37160407"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046132">
        <property type="term" value="P:pyrimidine ribonucleoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000008">
        <property type="entry name" value="Orotate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="71"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH57948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="238" mass="25833" checksum="6FB5C340F264BECE" modified="2022-01-19" version="1">MALPAYKTTFLESCLSANVLTFGTFTLKSGRHSPYFFNAGIFNTASLLSALSTAYAHTIITFLAENPSIPKPDIIFGPAYKGIPLACATLLELNRIDPATWGSVSYSYNRKEAKDHGEGGNIVGAALKGKTVLVIDDVITAGTAMRETLNLVAKEGGKVVGFTVALDRLEKMPGPKDENGVEDDKPRMSAMGQIRKEYGVPTTSIVTLDDLIKLMQEKGNEADMKRLEEYRAKYQASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2L2</accession>
    <name>A0A8G1R2L2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_519908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515944.1">
        <property type="nucleotide sequence ID" value="XM_025665086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2L2"/>
    <dbReference type="GeneID" id="37168488"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000058">
        <property type="entry name" value="Calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000257">
        <property type="entry name" value="Calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000027">
        <property type="entry name" value="Calmodulin (CaM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="163" mass="18614" checksum="8776E1066F683092" modified="2022-01-19" version="1">MLAMEVVSLTLHDYKADSLTEEQVSEYKEAFSLFDKDGDGQITTKELGTVMRSLGQNPSESELQDMINEVDADNNGTIDFPEFLTMMARKMKDTDSEEEIREAFKVFDRDNNGFISAAELRHVMTSIGEKLTDDEVDEMIREADQDGDGRIDYNEFVQLMMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2M5</accession>
    <name>A0A8G1R2M5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_398838</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514577.1">
        <property type="nucleotide sequence ID" value="XM_025657070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2M5"/>
    <dbReference type="GeneID" id="37160472"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000023">
        <property type="entry name" value="Putative ferric-chelate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF24">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="292"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH56655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="600" mass="67873" checksum="084304C7E280EF39" modified="2022-01-19" version="1">MDSDLWYAMLNDTLCYANLWVLACMIVVVFAWQSSGRLSAHLRRLASFTDHRQTYHRVPNIHVAWLKRHLLDAPLLRSRHNQEWQLSRAVNMGTLPSRFHTLLLTVIVVMNIVLCTNTVPYGSKESTVAALIRNRTGYMATANLFPLLVMAGRNNPLIPLLRVSFDTWNLLHRWLGRIVVLEGLAHVIAWGVPKVQTYGWSTALGTLSKPFMFNGLMGMVAMLVILVQSPSPIRHAFYETFLHLHIGLACVAVGFLWHHVYRYSCRYYLYAAIAFWAFERLARLLILIYRNYGFGRRTTAYLEALPGDAVRVTLQLARPWTFSPGQYCFVYIPKLGAWTSHPFSIAWGETGQTLLGSYSEKMAEVEMGNDHGQPGLESRKVNTVSLLVRRRTGFTDKMFTEAFAYARTRLPPDTISTSPRSTTTDISTAAMPVTAFVEGPYGNLHSLDSYGTVLLFAGGVGITHCLPFIRHLVQGYSEGTVAARRVTLVWVIQSPEHLDWIRPWMTTILGMEGRRDVLRIQLFVTRPRNPREIRSPSATVQMFPGRPDVGTLVQMEIENQVGAMGVMVCGNGGLSDDVRRACRQRQGLTQLDYIEESFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R303</accession>
    <name>A0A8G1R303_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_520935</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514757.1">
        <property type="nucleotide sequence ID" value="XM_025665177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R303"/>
    <dbReference type="GeneID" id="37168579"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="436"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH56835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="535" mass="59213" checksum="195B547AFBA05335" modified="2022-01-19" version="1">MFGRIGGNTLRCAARRPAARRVLLYERKFSANTCHASSSSPASSVASPLGSITTELDRISPCFEVPASRITILDSPANFYNTLKDKIKKARKRIYLSTLYIGKTEHDLIDTLDQALGANPELKVSILTDALRGTRETPNPSCASLLASLVEKYGADRVEIRMFHTPNLTGLKKKWVPRRINEGWGLQHMKLYGFDEEIILSGANLSSEYFTSRIDRYHVFHSKELTDYYAGIHNAVCSLSFQVLPDSQNAAGYLLNWPASNGAPSPLDQPEDFIAYSSTVLNPLIQPSKNQSTLPPKSPDQTYIYPVAQFTSLFKPNDTSTEFPAVTTILRLLSTSPAFSGARWLFTAGYFNIHPVLSSLLIASTSASHTDSTTRGTVLTASPWANGFYGSPGISGMLPAAYTHLSARFLDRVADAQRTNSIQLKEWRRGTVGQPGGWTYHAKGLWITLPKEEHPSLTFVGSSNYTKRSYSLDLEVGALVVTGDAELKRKLGAETERLQEDAKAISREDLRRTERRVSWRVRLAMWIVEKVGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3A9</accession>
    <name>A0A8G1R3A9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_477086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516304.1">
        <property type="nucleotide sequence ID" value="XM_025662816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3A9"/>
    <dbReference type="GeneID" id="37166218"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH58382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="221" mass="26167" checksum="EE482B7D7ADC0C47" modified="2022-01-19" version="1">MGLSCDNRRQSTTCHADKMGALKYVEEIQKKKQSDVIRFLLRVRCWELRQLNAIHRASRPSRPDKARRLGYKAKQGYVVYRIRVRRGGRKRPAPKGATYGKPTNMGINQLKYQRALRATAEERVGRRCANLRVLNSYWINQDSTYKYFEVILVDPQHKAIRRDARINWICNAVHKHREARGLTATGKKSRGINKGHRYNNTRSGRRHTWKRQNTQSYWRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4L2</accession>
    <name>A0A8G1R4L2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydantoinase/oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_416615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517380.1">
        <property type="nucleotide sequence ID" value="XM_025657739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4L2"/>
    <dbReference type="GeneID" id="37161141"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1610.10:FF:000001">
        <property type="entry name" value="Hydantoinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.390.10">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="entry name" value="CV3147-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048350">
        <property type="entry name" value="S-Me-THD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024071">
        <property type="entry name" value="S-Me-THD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010318">
        <property type="entry name" value="S-Me-THD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="S-Me-THD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF10">
        <property type="entry name" value="HYDANTOINASE_OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20906">
        <property type="entry name" value="S-Me-THD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06032">
        <property type="entry name" value="S-Me-THD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160991">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="1">
        <location>
            <begin position="214"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD N-terminal" evidence="3">
        <location>
            <begin position="622"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD-like C-terminal" evidence="4">
        <location>
            <begin position="788"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH59458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1000" mass="106697" checksum="71C18BF374E0DA1C" modified="2022-01-19" version="1">MGSVIEPRYRLGVDVGGTNTDAVLVRLDPVAIVASHKAPTSPDVTTGITTAVQAIIAAANVPLSSIGCVIIGTTHFVNAVVQRSPSLRRVAVIRLCGGPDEGFGRSIPPFVDFPLDLRARIEASRPYFCHGGYQISGEEISPLDETELERIGTQLVNDGIKNVVIAGMYAPLDHRQEMRAKEAILRSMEKHAGPSYKARITLSHEVSGLGFLARENAAILNATLRPLAERTIYGFQKAMEDIFQDVPYTLYLTQNDGSVLSAAEAVHLPIRTFNSGPTNSIRGGEFLWRAATEAAQLQKEQTTRTEPLVVIDIGGTTSDSGLLLPNGLPQMSSVTSLVGGVRTNFALPAVESIGLGGGSIVRSIGQDDCSVGPDSVAHELLEKARLFGGEYLTATDIAVASAVHGVTEMNPLKGMGDTTSLADINIAMIHQAQSIMRRKIEELVDRTKIHKDDVDVLIVGGGAPIIRTDEPLLGVRRVQTVKGGEVANAVGAAISRVSGVIDTVVDTSNCTVKDAQEAVSQMANDRALGNGARPDTVQIAEVTMLPIQYVEAKARIVVRAVGELDIVATSSADKAVPIPDEEVHETDTLAPPLHASQLTETQPDLHSYRPHIQNNQWIISPTDLDFITRGCKILGCGGGGDPYQEYLKAKAYLQNHPGTVRIISPDSLPDDSLVGWTGCMGSPEVSMERLENSECLQAHEELMRVTGSEPVSAFLALEIGGGNGMVNLGVAAHYDVPCLDADYMGRAYPTTWQVTPNVYGTPRGEALVPAAIASGDGTCMTMMRSRTDRLVDKAMRAAVVEMGCRAGSAGPPHRAERVRQQAIRNTVSLAWWIGRAVTLEKNIADKAMRIVEAAGGPESGAILGEGKVVSVSRVLKTGHSYGVLEVDGRLSDGRKATLNIPFKNENAYVEAVMEDGETRILAAVPDLIVVLDAESGAGLGTPEFKYGLKVVVLAIAASPRWTDTPRGMELGGPKSMGFEEVEYVPIGKYCEPRSVIDVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4P7</accession>
    <name>A0A8G1R4P7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo-keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_422678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514692.1">
        <property type="nucleotide sequence ID" value="XM_025657981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4P7"/>
    <dbReference type="GeneID" id="37161383"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF7">
        <property type="entry name" value="REDUCTASE (YAKC), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="326" mass="36252" checksum="3A3A2D02D4B2DB11" modified="2022-01-19" version="1">MVKTLPFQDIQVPSPGFGAMGLSFGLGYNLSLEEAEPVLLKAIELGCTFWDTAVIYQAGVNEKLLGDFIRKHNVRDKIFIASKCGFKVESFTVTNSASHIKEYIEGTIERLGFTPDLYYLHRIDPNTPLEESIPALDEIRKAGKTKYIGLSECSAATLRKANSIAKIDAVQAEYSAFETLHETDGLIDTAKELGVAYVAYSPLGHGWLVDDFPFKTPEDFAPDDFRRGSPKFQGENFYANKKIVDEIKRIASKRGCSISQVALAWVAAQGMIAIPGTTKAHRLEQNWASREIDLTDEEKAEMRKIIDAAKPQGNRYSERHQAMVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4V0</accession>
    <name>A0A8G1R4V0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_519390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516449.1">
        <property type="nucleotide sequence ID" value="XM_025665047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4V0"/>
    <dbReference type="GeneID" id="37168449"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="684"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="739"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="837" mass="88789" checksum="F53059B2707A8E86" modified="2022-01-19" version="1">MGQLLTTKWLPYVTVAPTSVLTVTSTYSDTVTSTVTGVLPVTTVETTCTPGSVAPESCSNSIWSAEGSYWQEWCSDSALEGAPFMTIHGATSPYECFVFCGIYSSCQGLNWDDNNECVLLTDITSTVEVTSSHWAAIERFSTNPCVVTVTGASTQLSTGTTVMEYTTTYTSTITLSTSASVASTSTTSSVATSTASTCTVSTFPTTTDCVDGYYVYNEEYYQVLCSDTVQSYSGTLSNSRQDDIWGCIEVCSTYSNCIGTFWFLGICYSESGAIDHSYVPCDFYCCYNLFHNPILVDTCVLIGHIDIIKTYRQIYASRAICINCFTFHSFKRLFISCDIEIVYFIGPVNTNVPGLKLQELSFSRLLCCILKSPSFCPLEELLGTHTSAIVFFSCLSFILCVIAASFQFFYFSKLYQQHSHGFQSEYPYVSPAYYDHIYHCNPHLNDYDLSSEGYQNGFHSTTSRCYLTCRTKDDNFNCLHHKGALATSTVFTTKVHTMSGCPQESPHCVASEKTTYYTTDTIAAYTTIGPVAAEETSTHASGQATAIGEGSIGQSSERLSTSTGYTTRVHPITACPSSSTTCADAERTTYPATETAVASVTLITSAAVETAADNSGAQVTPSGGKSSASIITVVLYTTEVYTIIKGTKTHLTTAAVQITTTTTPTASEIPQFSPTRKVGSALLGPHSPQQGGSGGSTIASGADADGQIGVSAESQGSTGEGSSSPSSSNGDSTHPDRPGSPGSSPHVSPSTVSSAGSVAHSSLNVGSWSSVSHYLGVPSPSIGLNRPTLGSVAGSHTASVYASGTSTVVSVQYTSSASKSAVCTLFPFLSMAIAYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R501</accession>
    <name>A0A8G1R501_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 8">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="1 8">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 8">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_448425</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="1 8"/>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516286.1">
        <property type="nucleotide sequence ID" value="XM_025659931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R501"/>
    <dbReference type="GeneID" id="37163333"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070154">
        <property type="term" value="P:mitochondrial lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000094">
        <property type="entry name" value="Lysine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF5">
        <property type="entry name" value="LYSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="214"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH58364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="568" mass="64469" checksum="B2F22A890D956707" modified="2022-01-19" version="1">MFRTGLPISRTSQAFQTSGRLARVIQHTHAPLVQTRQNSVDAYPEKAFKRRVQLIEEAVAEPYPRLASNKNTVSCTEFRGRYSHLADNEIVEDDTVVINGRVRTLRLVGGNLIFFDLLHDGHKIQVMCNRRRLKDIPPATFKQFYRMLRRGDAFSVTGNPHRTERGELTLLATELPQLLSPCLHDIPVDAQGQENSPYPRHVQFLADPETVNVIRARSAVVQYLRQFFVDRLFMEVNTPIIEAVAGGAIARPFHTTATEFPDRQLSLRIAPELWLKRLVVGGFDRVFEIGPSFRNEGLDKTHNPEFTTCEFYHAYANLEDLMTTTEQLLSGLAEHLTAFHKSSPFKKPNQEDTPLPFSHLNFSAPFRRLDFITSIEQSIEQKLPDLTSPDALDQVKAIFRDRNHALPDKVTLPRLLDELCSIYVEPQCIDPTFIVNPPECLSPLSKSFIHPTTNQRVAARGELFIEGREVVNTYEEENSPFEQRRKFEDQVRYSKQADEAEEIDESYLKALEWGLPPTGGWGCGIDRLCMLFTGITRIGDILPFGNLRKVTTRADAAAEGQAAEGKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5A6</accession>
    <name>A0A8G1R5A6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_459207</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515927.1">
        <property type="nucleotide sequence ID" value="XM_025661636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5A6"/>
    <dbReference type="GeneID" id="37165038"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="592"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH58005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="677" mass="76003" checksum="DB95C502D8C1B9E4" modified="2022-01-19" version="1">MASTSAERPAKRVRQACEPCRRKKAKCPGEQPVCSLCARLNQQCAYAGEHRRSSTAGLAIPREGASVPPGSENRISEILEERLGSLEARMGQVLDALGQNSPRQEPREAAPRTAVMSNAVASLLSPNIPFPTWEKVLAMAELYLIYCHSQPLPLFQKEGFLDSLRSRDPEIVYAMLALSIRFSQDESSQTGGFTSLVNGYTEVARGLVMRRVSEGPIELSTLQSLCLLSLVDFANGNTHRSSIHCSLAMNLAQCANLGLESGLVQPPAAREERRRCFWSICLLKRLHGVDFDNLDFPDGCFPQFPESPSRPPPTISSSNGANETRSSGMQDQGILAYVIMLSEIFAKTAKYVRRHGKPSNVPPWSSQSEYSKILTALMERETQMPYSHRFKPANLSERTLEDLQERRDYWGPWLLNQFLYHTILCLLNHPLLLSLSLRNFRSTIPEIFLQHSSDLISSHTTWIIHFIDYFEERSFVVSDPFLGYSAAVVATIELQLSFTENTTIREEKRNRFYKCVSFVQNLGRKWPHMARLADRLQSLEDAVSASYELESGAQNKYLLIDLSRFWEILEYSSNSDAESACRMFGDSLYSEAPTPGAEVSQTSPLPEPFRLHTQQSLPQSPTSQFNIQTPIITADAQYPMGVDSPTYDEYSILATNFFSQAQDFLRSGDPRNGFGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5B1</accession>
    <name>A0A8G1R5B1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucoanthocyanidin dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_458141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516858.1">
        <property type="nucleotide sequence ID" value="XM_025661563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5B1"/>
    <dbReference type="GeneID" id="37164965"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="158"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH58936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="310" mass="34928" checksum="3F67B552D6C6F5E3" modified="2022-01-19" version="1">MAERVVPVISLDDFERRKDEITQQLVHAAETAGFLTLVDHGLSVEEIERQFAISKSFFDLPSDVKGKTPHSNVTNNGWEYKAQRRPSTGLYDQKESLWLQHGSHWPSDEDVPGFRDATTHFMAKCAIISEQLFTCFATALGFPSDYFCVANDVTKPDCLTQLRLIHYPPTVDAAGTWRAGSHTDIGCLTLLFQRDGEDGLEICPGRESHTSFAMGDVFSPLPAKTGQIVVNIGDMLMAWSDDRLKSTFHRVRAMDVGESPSRYSIAYFNQGRRDYIMQGPQKKYPPKSVGEWFKESVERNFAYQQSVTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5I1</accession>
    <name>A0A8G1R5I1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_436545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517504.1">
        <property type="nucleotide sequence ID" value="XM_025658577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5I1"/>
    <dbReference type="GeneID" id="37161979"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000008">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH59582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="240" mass="27422" checksum="013EDFA5FE48A1CC" modified="2022-01-19" version="1">MFQRTFLRQAQRSLRSVRPTSINTSALRRTPQLPQTVRPIAPQSAYRFYSTENKAENGEKKEGESAQEAEDPVRKELEEKKKEVIELKDKLLRSKADFLNLQERTKRDMENSRNFAIQRFAGDLLESIDNFDRALLAVPKDKLDAPQTEANKDLLELVSGLKMTQNILLNTLKKHGLERFDPSEPTEDGKTQKFDPNLHEATFMAKVEGKEDGDIMYTQSTGFRLNGRVLRAAKVGVVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5J3</accession>
    <name>A0A8G1R5J3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_510590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517595.1">
        <property type="nucleotide sequence ID" value="XM_025664554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5J3"/>
    <dbReference type="GeneID" id="37167956"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH59673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="363" mass="40357" checksum="71E5DE91D5A19F13" modified="2022-01-19" version="1">MSSDIPRPPTLRRSCQACARGKRRCDQRWPRCTRCQTRKIDCEYINIPLTVGSDTDPTSTATTTITTRSTLSPKLPHKKPRQHYQLTHSIPIPLPLEITKGYSQPIIAYLVSGMRAYPSTFALNMKTHFIHPDLWPSPSSPPLPIKDIHTLCKLHSTSPTTTNKTIIPLLKQKSSSLLRTLNHTSSFEEMLATAQALLLAQCMLILSDPDTDTSSQAYSESISTMLYNLGQKLWQQAPIQLPGSLSPRRAWLFAESVRRTIIVGFMLRSVYSLKMRNYSVRTPFVDSLPFDMRTGLWDRDVGVDGDEGGESLDAMVSLHQYSGMLESGVVHGISDFGGLILAACRGRALQGVPYPSVTAYAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R604</accession>
    <name>A0A8G1R604_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_518954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517049.1">
        <property type="nucleotide sequence ID" value="XM_025665008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R604"/>
    <dbReference type="GeneID" id="37168410"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034541462" evidence="2">
        <location>
            <begin position="21"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="3">
        <location>
            <begin position="128"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH59127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="375" mass="39660" checksum="8172B53E1EFDA380" modified="2022-01-19" version="1">MVQLNTLLTGLAGLASIVSAHPGHDIRAEAAERAAFMKRAPRSLSDCSAKLKARGLEKQSIARRENAVNAIRQKRGLQTHAPLLKARDLDTILNTTHHSSLNVSPETDPNVLFASNATCVLGPDVTQGPYYVTGELIRNDITETQEGVPLYLDIQLIDTSTCEPVPEIYIDIWHCNATGVYSGVAASGNGDSSDTSNLDATFLRGIQQTDSDGVVQFNSIFPGHYTSRATHIHVLSHSPNETTALPNNTISGLYTSHANYVGQLFFDQDLITKVEATSPYSTNTQELTENADDSILSEEADTIDPFVEYVLLGDDVSDGVFGWISLGIDVSENSEITPAAEYTADGGVENDSSSSGMGGGGGSAPSGGAAPSGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R685</accession>
    <name>A0A8G1R685_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_437627</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516377.1">
        <property type="nucleotide sequence ID" value="XM_025658628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R685"/>
    <dbReference type="GeneID" id="37162030"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="4"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH58455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="329" mass="37086" checksum="888021DE917A5762" modified="2022-01-19" version="1">MLPTCTRCRSRRIKCDSLLPACANCSKHDVECTFRDEALQVDVTRCYLKTLQDKIEKLNTELAVNSQISSRANWDLESESGLTETTPDGIPTELSSISSFILMPGSGKDLYIDLSLPSRIVEVTLEVLSQRQETDDKMTVDEESFSFPDIPRLDRSTLTPGAVRGLLKDYHRLVQPKYDILDVGILSYDGMHLRKLPETRKFQILMACAISATQKSYKEPIWKPFANTCREWANDFIAPIISSADADSMKALLLLLVYEMADPTRGVIWELLDVARRTCLQLGWNRTASSSNETTINGEAVSHDPMRTRLMRVLRDIEGLVQQPSPLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6G3</accession>
    <name>A0A8G1R6G3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_466916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518306.1">
        <property type="nucleotide sequence ID" value="XM_025662154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6G3"/>
    <dbReference type="GeneID" id="37165556"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH60384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="553" mass="62851" checksum="65139D0EE835A657" modified="2022-01-19" version="1">MSLHQDYSTSSEFPPSQITAPIDVGSHIVHRDGLITELIARLKAFHIVRVRGTPASGKTTIVNLLANKLLDCDPNTPLYVMSGWDVDMVTRAKGWAGYLEQRTGVHGRSWLTQRGYLLIDEAQQSYWDVALWADLFKAVDPSSQPYIVLFMSYGSPDRGFSGFERKYMATPMIFGEGQEISLRPDINIQSPWKPVGLLMEENEAIQVIERCAPQVIPDCGPLLTPALKRGLFKSSSGHVGLIKSLVLALRSLPVLSKEVRNRRPLEWQTISTAFFSDPMGFFRCLRSLPFSRGLPPARILQIPNVAAVLKAAIASDGILTSSFAGTSKEAQEGLEHILANGWLHAEICDGGERYIFASQIHRWYCQCLFSEKRPDNQLEYDTPLQLALDVIRGFQPCQLAHAPRSLAGSSRPLEDQYQKEFYRCLFPLLDGHVVVSPEFVVQSDIKGGTIDFLITQKKWGLELLRERDRLQEHMDRFKPNGQYYTLIEKGRMDYYIVLDFTTTMPRKPNPEFQNRLYHIVFSKTYRDVSVINGWDLRVVDAFVLMENKIRRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6L4</accession>
    <name>A0A8G1R6L4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_265303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517126.1">
        <property type="nucleotide sequence ID" value="XM_025655048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6L4"/>
    <dbReference type="GeneID" id="37158450"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="203" mass="23313" checksum="52A14F81802C6996" modified="2022-01-19" version="1">MFRSWFPVFATRSSIAPQDTLAAFEVSSKSIREFPSLKSITTYQPSLFSLADITGHHLWSPSVLNAHVITEIPEALVFFPFLFSFFEKSEKEKIIKKENEKRNFSFPIFFIIFSILFYFIFLVLILFFTPSLFLFVPFFPSIFSLTFPPPPYHPSLTLAKFDHRDLLIVFLPSTASLLPPGLFSFPPSPIRAHLIPRLLPSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6P7</accession>
    <name>A0A8G1R6P7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_391652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxB family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518119.1">
        <property type="nucleotide sequence ID" value="XM_025656817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6P7"/>
    <dbReference type="GeneID" id="37160219"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039020">
        <property type="entry name" value="PaxB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038:SF4">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25129">
        <property type="entry name" value="Pyr4-TMTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH60197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="249" mass="28858" checksum="08715384009ECE9E" modified="2022-01-19" version="1">MPSFTLASQTPHLIIQPSDAALSPPESYLFVQDGLIISCGILYAFCYIFCMIRTYSDRTYPSASAKGIQFMSLTLAYELFYAVVTTTTTFELLAFLAWFLLDVGFVAVAIWRAHEKRDRAWLVRRIVGFVLAGMGVLKGLTMLWPDEREQVTAYWTGILLQMPIGWICLATLWKEWNTKGHSLEIWLMRYLGCYTAYGVFFWRYWNVPQNWEYVASVWSTGIILWTLLPETVYPFVYVWVHRTSKVKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R725</accession>
    <name>A0A8G1R725_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_193615</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COPE family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519223.1">
        <property type="nucleotide sequence ID" value="XM_025654452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R725"/>
    <dbReference type="GeneID" id="37157854"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000613">
        <property type="entry name" value="Coatomer subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH61301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="295" mass="31691" checksum="77B762E1EE0B9B5E" modified="2022-01-19" version="1">MDPFSAEGELINIHNAFHQGQYQAVIEFDTSALSPENQLPARVLQLRAKIALGQTDEVLADVEGEEETPDLAAVKALAQQSAGDAESALKLAQDLAENYPDNATVQVLCGTLLQAQGQSEDALALLTKHQGNLEAVALIVQIHLQQNRSDLALKEVQAAKRWAQDSLLVNLAESWVGMRLGGEKYQAAFYVYEELASAPSTSAPLSIVGQAVAELHLGRLPEAEAALTAALQQYPDEAELIANSVVLIVLAGKPSEELEQRLEQINPTHPLLSDLQAKSELFDTAAAKYAPRVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R756</accession>
    <name>A0A8G1R756_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_518320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517426.1">
        <property type="nucleotide sequence ID" value="XM_025664967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R756"/>
    <dbReference type="GeneID" id="37168369"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF11">
        <property type="entry name" value="O-METHYLTRANSFERASE (AFU_ORTHOLOGUE AFUA_2G17820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="64"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="176"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH59504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="401" mass="45040" checksum="B9B79B22814EBC30" modified="2022-01-19" version="1">MAVDQSKVLSLVETIKQTALQDQGACRSAQSHFQLLGLIDELRLAVETPTETVLRLIYQPPQNAALRTVMDLGIFPLLVEQSKRGMSATELSAQTGAERGLIVRLMRVMTALGLCANPESEVYIATDKTVALTQPIGRDGIPCIYDLTLPTLAKLPDYFREHRYISPKEYARSPMQWAVGKSQFEWLAQNKHRQSLFNSYMSSRRHGKPSWFDVYPVERLTNDAVDHQEAVFLVDVGGNQGHDLVKFQDKHAEVPGRLVLQDLPKVVSRCPGGRIEGMGYSFLDPQPIKGARAYYFRAIFHDWPDHICRKILVNTISAMDPEYSRIIISDFVLPDTNAPLLQSSLDIQMMSIGSGVERSERQWRELLDEAGLEITGIWNSNPGMESVIEAVPKRSQRCSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R767</accession>
    <name>A0A8G1R767_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_457838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517679.1">
        <property type="nucleotide sequence ID" value="XM_025661546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R767"/>
    <dbReference type="GeneID" id="37164948"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="169" mass="18325" checksum="A3BE4D249DEEFAC8" modified="2022-01-19" version="1">MKEEVIARTEAAAAREEEIIRKRADDPLKDLKAGGSSPREADGEPRAATANDEAGEGQRGGSTESPASISPAARPISRRFRRALKRPEVGMQRSREPTKCAKIRVNGPGQKLPAFLQPASPAGTNTQYYRLAVWTFRDPIVEILSGRISCLIGKVADFADSLQEEGNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7F4</accession>
    <name>A0A8G1R7F4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_447262</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518615.1">
        <property type="nucleotide sequence ID" value="XM_025659683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7F4"/>
    <dbReference type="GeneID" id="37163085"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH60693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="261" mass="30040" checksum="882E2C5B0E0E679D" modified="2022-01-19" version="1">MPQNEYIERWQKQHGKRLDHDERVRKRQARESHKQSKDAQNLRGLRAKLYQQQRHKEKIQMRKRIKEQEEKNVKSSAPDEPSKTPLPQYLLDRSQATNAKALSSAIKDKRNEKAAKFAVPLPKVKGISEEEMFKVVNTGKKTHKKSWKRMITKPTFVGSDFTRRPVKYERFIRPMGLRYKKANVTHPELGVTVQLPILSVKKNPQNPLYTQLGVLTKGTIVEVNVSELGLVTTSGKVVWGKWAQITNNPDMDGTVNAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7H6</accession>
    <name>A0A8G1R7H6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lactam utilization protein lamb</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_261714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517067.1">
        <property type="nucleotide sequence ID" value="XM_025655030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7H6"/>
    <dbReference type="GeneID" id="37158432"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003814">
        <property type="entry name" value="PRK05406.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292:SF0">
        <property type="entry name" value="5-OXOPROLINASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBGL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="254" mass="27701" checksum="5F1AAF3C4F74B9D3" modified="2022-01-19" version="1">MPPLRTKVFINVDLGEGYGNFKCGPDEELIPLIDQANVACGFHAGDPLIMQETVSLCKKHNISIGAHPGLPDVQGFGRREMKLSPEEHTANIIYQVGALQGFLARENILLHHVKPHGVLYGMMCRDLEVARAVIRGIPAGVPVVGLGGTYMEQAAKELGVPFWAELFGDVKYGPDGMLVIDRKKKPWKIEDVKAHVRQQVEDSSATAVDGSVVQMGVKDYPVTICCHSDSPGCLEIVKATREVVDEFNRANGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7I6</accession>
    <name>A0A8G1R7I6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mating-type protein MAT alpha 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_513895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MATALPHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516102.1">
        <property type="nucleotide sequence ID" value="XM_025664721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7I6"/>
    <dbReference type="GeneID" id="37168123"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045895">
        <property type="term" value="P:positive regulation of mating-type specific transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006856">
        <property type="entry name" value="MATalpha_HMGbox"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04769">
        <property type="entry name" value="MATalpha_HMGbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51325">
        <property type="entry name" value="ALPHA_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Alpha box" evidence="7">
        <location>
            <begin position="84"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="368" mass="41467" checksum="B100B5AD9B791E6B" modified="2022-01-19" version="1">MDATTSPLQRAFNAFLLTMPPQQLEELLRYLQDTQTKANNKVSHETEHPTARSKTPLDNNNESTVQASTNQRSNQTRGKRPQDGKRRPLNSFIAFRSYYSVMFPDLTQKAKSGILRFLWQNDPFKAKWAIVAKAYSIIRDDHDNGVSLETFLKLNANLIGIIEPDRYLDIMGWELNVDGQQQYTMAKVKITATPEAELSTNYSVDDIVKNCYDTGYVSREKCKKKTDHNKNAPVMAFAAQPTLIVHENNSIQINGNHTVVTGDCNGNAFVESAFSHNFSPSPGEMETMIAEASLDESEVLHGHGYRMYERGPIVAEEYNIDDEMLDFWGENPAMLPSYVSAAQSTLPPHDPCVPDPMANINIDHYLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R821</accession>
    <name>A0A8G1R821_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit TIM44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_414195</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim44 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518839.1">
        <property type="nucleotide sequence ID" value="XM_025657638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R821"/>
    <dbReference type="GeneID" id="37161040"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim44-like" evidence="14">
        <location>
            <begin position="360"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="78"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="84"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH60917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="520" mass="58326" checksum="75CBD44614BF57B3" modified="2022-01-19" version="1">MISATRMSVTARAATLRSQVPTLKTAAVSQRSLLQSCSYATSRNTLLNSQRADRPVSQLVSPFAALPLTRSFHVVAPRLQQQQQKDKQEQQEKQEKQEKQSEEPNQEKEEKSEGESKKEGKKDAPPPPPHGDKSPWQVFRETLQTEFKASKEWNESTKALASSAHQFSENENIKKARAAYEAASGAATSKTATALKTTGKAIGTSAAWTWNTPVVKGIRKGVNVTGSGIEKVTRPVRETEAYKSAVGGVKNAIDDGSSSRYGGYIEKEERRKQRKLREEAELKAGRRVEPMVEDPNAGTHVTLHKDSAWKESWRDFKDSNPMMQKLFTLKESYEESENPLISTARSISDRVAGFFAENETARVIKKFREMDPNFQMEAFLREMREYILPEVLDAYVKGDVETLKLWLSDAQFHVYAALAQQYTTAGLKSDGRILDVRGVDVSHARMLEPGDIPVFVVTCRSQEVHVYKNVKTGELAAGMEDKVQLVTYAIGLTRIPEDVNNPETRGWRLIELQKAARDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8I0</accession>
    <name>A0A8G1R8I0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_466772</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518101.1">
        <property type="nucleotide sequence ID" value="XM_025662146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8I0"/>
    <dbReference type="GeneID" id="37165548"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF8">
        <property type="entry name" value="PEPTIDASE M20 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="192"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH60179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="414" mass="45059" checksum="7B4F508DEE7AA2EC" modified="2022-01-19" version="1">MTATQTITQTVPTIDEVKVAIDAALESAKTSLRELNREIWCNPETAYQEHRAHDTICDFLEKQGFTVTRHAYGLDTSFEALSGSGGRLINFNAEYDALPDIGHACGHNLITTSSMAAFLALSTVVKQYGIPGRTQLLGTPAEENGGGKAKLIDLGAYKGVDVSLMAHAGPKELFPGVVADSVGGVRMNARKEIHCEFTGRSAHAGGNPWEGINALDALVTSYNNVAVLRQQLRPDERIHCAFLDTPTVANIIPSYTKAYWQVRSPTLKGLNQLMVKVRNCIEAGALATGCEAKIIENELYTDIKINDTLCDRYKAHMSKYDRNVIASLEKVMTGSSDIGNVSYIVPTLHTMFGITDEPGSFPHHPKFAAAAGTDYAHQEAVIVGKSLALIGWEMVTSDELFGIAQKQWKECIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8N8</accession>
    <name>A0A8G1R8N8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_485422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518191.1">
        <property type="nucleotide sequence ID" value="XM_025663326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8N8"/>
    <dbReference type="GeneID" id="37166728"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH60269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="168" mass="19609" checksum="77EEA099B6FB1B76" modified="2022-01-19" version="1">MLAKLQPGVIYIFVDKALLGNWVSEWGKFVDPTYALIKQMEFVMCHRSIFKSMDTQKFDKKFDKWKDGNHHEAFILPKHHLKTWLELSIIWQSGKITLADKKDLLIFENCEVHLRHSLSKTRLKGQLQRITIHNIPIARTFCDECYLSFSDSSPIVCILDKLKACCNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R904</accession>
    <name>A0A8G1R904_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_511440</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516897.1">
        <property type="nucleotide sequence ID" value="XM_025664597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R904"/>
    <dbReference type="GeneID" id="37167999"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF36">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 15" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034997479" description="AA9 family lytic polysaccharide monooxygenase" evidence="16">
        <location>
            <begin position="23"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="23"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH58975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="277" mass="29245" checksum="73527BD0A1521D42" modified="2022-01-19" version="1">MKEINTVSCLATLLSLTARIAAHGHVSNIVINGVSYRGWDINSDPYNSDPPVVVAWQTPNTANGFITPDEYGTDDIICHLDATNAEGHAVIAAGDKISLQWTTWPDSHHGPVISYLANCGSSCETVDKTTLEFFKIDGVGLVDDSSVPGTWGDDQLIADNNTWLVEIPPDIAPGYYVLRHELIALHGASSENGAQNYPQCFNLQVTGSGTAEPSGVLGTELYSPRDPGILIDIYQSLSTYEVPGPTLIPEAVSVVQSSSTITASGTPVTGTAASATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9T8</accession>
    <name>A0A8G1R9T8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HLH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_435418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519029.1">
        <property type="nucleotide sequence ID" value="XM_025658524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9T8"/>
    <dbReference type="GeneID" id="37161926"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00083">
        <property type="entry name" value="bHLH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="154"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="386" mass="40624" checksum="D1DB4070D2AA2D51" modified="2022-01-19" version="1">MSRSRLPPTPAMSGEFIVKDNASVDASDPFALPPAAISPSKMQAASRRPSKSDPSASFPASPASPNPALGIMANSPRQTGVKRPLEDFNLPPPPTRARKIIQMKPKTQSPPKPTAAANKASTKENGKTPANNGASANSKKKQPSATSAAGRKIARKTAHSLIERRRRSKMNEEFGTLKDMIPACKGQDMHKLAILQASIDYVNYLEQCILDLKTAGNRHTIASPRMPPAPPSPTSPEALAEESGLSSASVSPELPPTDAATDAISPVFSPRSGGPTGNAPNFSSITPSPALGPTHPSDNPSRSERGSWAMSSSSTSPVIQPKYSIASSADVDHEASAALLMLNRDCRGSVGSVHDVPTNSTTRHGHPHTQDPQRKIGMSVKDLLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA38</accession>
    <name>A0A8G1RA38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_244293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517452.1">
        <property type="nucleotide sequence ID" value="XM_025654868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA38"/>
    <dbReference type="GeneID" id="37158270"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="61" mass="7286" checksum="BA61384ACD5ABE9D" modified="2022-01-19" version="1">MTCSMIAMSMSIRIPVSLSFSLFSMMIMLLSIQRWQDYSRLRRNWIEWRFSKGRLVSVGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA77</accession>
    <name>A0A8G1RA77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_445861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520361.1">
        <property type="nucleotide sequence ID" value="XM_025659367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA77"/>
    <dbReference type="GeneID" id="37162769"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="249" mass="27365" checksum="05B3ADBABB82053C" modified="2022-01-19" version="1">MFTQASASHIKVVLKDDTLGLGARPKRDPLNEPTGLDAFKGLLGRLNGKSDADLQVEQQKRDNVKLARYAATKWQAVTFISGGLLAQEKMTPIVTKEPQGTKKDKQEDGLSATLPAPDKDQVSSDGVEGSGSGNVGDQSDHQSIKKKKSKSKSHREKKDRKRKHTDGPESTDSGDTSKKSAEEKSKAPRDDEESSSTASKGPSRERRPMGRHVFRGRNIAQKKAALMDEKSLNEVRTEHFIVVFSDRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAA7</accession>
    <name>A0A8G1RAA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_194900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519284.1">
        <property type="nucleotide sequence ID" value="XM_025654467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAA7"/>
    <dbReference type="GeneID" id="37157869"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="436" mass="48190" checksum="2DD38BF5A4B80BB2" modified="2022-01-19" version="1">MSAVKRAACDRCHGQKMRCIREPTKSSCHRCLAAGALCVYSMARKAGRPPTRQQSMKDTSGGWRPASSNRGEQRNPQQQRRRRQQQQKQQRPYSASLEGSRGPQENDSILEGTNDAQPSFEAMLLDAVTDDSETLVPLFSNSMPTIPGLGIWDDGDTSRPYDEGASHPLSTDSNHQQVDFMMDQAVVSDSPLLVTECSQPGTGTKPIEYEFIVPPIAGNVIQQLCALSVKLASHMKSLSSIDSDTANNPMPRLERLAANVIESSVEFHRILSEARSMLEALDGLDPLLSDTAMILQVLSAYIRLTQLYYALYQDMNSVLMKLSDCPSHESLPSDIFVPFPMLHIGGVSLSSYHRFQLKFVLQICVHHLGETETLLGLPADLCVSERMVQEEGILHQSTGEMAFLVRTIMRQAEKTVKGIRGVLAELSERTKGAIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAH2</accession>
    <name>A0A8G1RAH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BO85DRAFT_433206</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">GPI-anchored chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Required to reshape the cell wall at the sites where cell wall remodeling and/or cell wall maturation actively take place such as sites of conidia formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520511.1">
        <property type="nucleotide sequence ID" value="XM_025658415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAH2"/>
    <dbReference type="GeneID" id="37161817"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000150">
        <property type="entry name" value="Class III chitinase ChiA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF47">
        <property type="entry name" value="ENDOCHITINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="11" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 20" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 22" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034980894" description="chitinase" evidence="22">
        <location>
            <begin position="22"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="23">
        <location>
            <begin position="28"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="346"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="468"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="559"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="709"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1067"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1123"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="348"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="559"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="709"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="788"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="919"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="946"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1074"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1126"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1142"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RAH62589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1241" mass="121235" checksum="BD29F611415C804F" modified="2022-01-19" version="1">MVFKPLTLAAAVAGLTPFVSAFDAQAKSNVAVYYGQGYGQQRLSHFCQETSLDIINLGFINTFPDQGPAGWPGSNFGNQCDGLTYVVDGVSTELLSGCHQIAEDIPICQEAGKKVFLSLGGASPDNQQILSDASAVQFADFLWGAFGPKTEEWVSNDGPRPFGDVVVDGFDFDIEHNGGFGYATMVNRFRELFALVPERTFYISGAPQCPIPDPQLSDAIAQSPFDFVWVQFYNTAGCAASDSINGVSTGFNFDDWVDVIKRGANPDAKLYVGLPAGPAAAGTGYYLTPEEVYPLVNVYMNLYPETFGGIMLWEATASDENTFNGLTFADLIKDILVAVDPSPPVPSPSSSSAIASSTPAASSTPVASSAPASSTSTPSSSPVPSSSAVSTPAVSSTTESSSTPVVSSSVSASSSPIASSPVASSSSILSSTAIASSTPVASSAPVTTSAAGASSSLIVPSSPVASSPAVPSSSAVTSNTPVASSSVVAPSSPIVSSKPAASSSAILSSTPVASSAPAVSSSPTASSSAIASSSAIASSSAIASSKPAASSSAIVSSTPAVSTPVASSTPVVSSSATASSSPVASSTPGVSSSPVVSSTPAVSSSPAVSSSPVASSTPAMSSSPPASSTPIIPSSAASSAVASSSPIPSSSIVRSSTHTSSNPVVPSSPAISLTPSSTPVRSTSSVAPGKSSSVPIISKPSSTVIASFTSSSGSLPSSSAPAGTGVPSSTLSHPSSTPLLSSSPVSSAEPVSSTSAVGSSVGSSSSMVPEVSTRSSLSVVPPSTPIASVSGTTIVSVTTSSSESGSPTVSSSVNTSSTDASTRASATSVESTSSGSVITSVTPSGAPHASSSTSSVVTTISSVPSDSSSSSGSEITSSTESASSTSSQTGAKTTSVASGSSAAASTSTSGAAANGSGAQDSTKSTDHASTFSSSYSTPLASVSRQTDGATTVPTGVPTGNGSGLAPITSSITSAPAVPLVTSSGSESEPTITTTVIVTSYIDICPEGFTTITTTYTTTYCPATASATATVTNPPGAPAQTTSPSVPEGWTTTVTVCTHCAPTPTTVTLTLPATNRPSGLASSTSAPNSPEDWTTTVSVCTDCGPTPTTVTVTVPVSAATGVDALTANPSGSQSTGESSPGQSAPTAPTAPASTAPTTTATVIVAPSQSSTSQPVILGTGSVRASSTFHIQPSQSGSRVPVAPSGTAAGVSPVFTGAASRVSQLQHGAGAVSAFALFLLAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAR7</accession>
    <name>A0A8G1RAR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_517232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518927.1">
        <property type="nucleotide sequence ID" value="XM_025664892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAR7"/>
    <dbReference type="GeneID" id="37168294"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000326">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.150:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="358"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="478" mass="53435" checksum="37C84F5E62C5CE48" modified="2022-01-19" version="1">MSSLPLEPPTYLSSLQNNIRARPIPWEGAVRAGNITDDHLKKIKAVDKVRKEQRRQTVEGDLAGYVGLLSGGSEGKSVLDSASRRTDIVQYILVLAADLINDVPSLSTALVAHPDPYKPFLPLLRHSTNPEDPIPLLTSTFLTNLVSVSLGTSSKPAARDDEALPQLYTYLSTLTQNQDSGLQDIGVQELSALLRTSRSREIFWKQRQQTVEPLIEILRAATGAKDNSSSTLAGSSRAIEPGLAGGVGLQLLYRVLLVLWQLSFEGQLIGDDLQADYEFVQLYTHLLRLSPKEKTTRLLLATLNNLLSSNRTTLLPVAVFVRLPALLTNLAGRHLTDPDLLEDLTFLSEMLDEYTKTQTTFDQYAAELQSGHLRWSPPHRNPTFWKDNARRILDENNGALPKKLSEIISKSWDNDKQVLAIACNDVGHLVKELPERRAQLEKLGLKTRVMELMTDKDESVRWESLRAVGEWLRYTFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAS6</accession>
    <name>A0A8G1RAS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_485066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519256.1">
        <property type="nucleotide sequence ID" value="XM_025663295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAS6"/>
    <dbReference type="GeneID" id="37166697"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="138" mass="14749" checksum="5F14F13E1108CF90" modified="2022-01-19" version="1">MPANTRIQSSASKLHNLLVPRPPTPCLLPLRSIWQPAAIHTPRSVQARLNSGLGKDWKGTGAEDNAVNRAEKNDTTDPTTDASASVMQDRKEGGGNDAKPQGATEKGGSQHGKKAKQEHPKAPEPIIGMNDERGHKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBK8</accession>
    <name>A0A8G1RBK8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_411810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521593.1">
        <property type="nucleotide sequence ID" value="XM_025657541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBK8"/>
    <dbReference type="GeneID" id="37160943"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000282">
        <property type="entry name" value="Glyoxylate reductase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="57"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="119"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="6">
        <location>
            <begin position="744"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH63671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="997" mass="111431" checksum="8D96E271EA1E3BC1" modified="2022-01-19" version="1">MPAALLIGAITHSIPEWNDLSSILTLKEFPSGTREDFLRNCRDGQYDDVVAIYRSNTSTKFTGPFDAELVSVLPSSLKYIAHNGAGYDNIDVAACTKKGIAVSSTPVAVNNATADVAIFLMIGALRQAYIPVSSLREGKFLGQTGLGHDPQNKVLGILGMGGIGREVARRARAFGMTIQYHNRSRLSPELEDGATYVSFDELLANADVLSLNLALNASTRRIIGKSEFQKMKDGVIIVNTARGALIDEKALVEALESGKVWSAGLDVYENEPAIEPGLVNNPRVMLLPHIGTMTYETQREMELLVLNNLRSGVETGKMITLDALHDPESLALQRPLLSPVYPILQRIPTHTLTRSAKNKKQKANPQPGLRPELCDALPWFRSVQGGVYHNGNICWGFLIDADCGIRSYLDDEVVITRVGGGCTKDANGDLVLIKDQDGDSAAMSSILTSMELNVPVGIVIGNRNTLLNRSLPHRYNVMAYFRITHVWYERIGRRTGAKVRFEKVDLGSKSWWAAKHSPSPLERKKRDYAMQAEQARCGACNQYSVRIYDQGWMCLQSSCKLFWMISGSSSAPADLIFHEKFLKSRLPPDPTIHPHYSLVPDLLSTLKGVDSDALSKRITWKGIICPLCKRCISRRYWWGWRCADDDSVRDREWKCPFEHILPIRPIALRWVIDDMEMSPIKRALSWDAKFMVPEVDDVSLYPYRKLTYTIPGVGSIMHLVANREINTRRNGPDKLFEQLQCEELGLRRYPLAQNVVAETLTAHFAVNYGMPYKYVVSVSSKSFKEACPPILRAMGRLIWASKQAHLTAGDIFLPPNEMLLLGYLEDMRIGYHDDGESSLGPTISTLSLGAKSTMLVRMKYKYYHGYSRAKKLLEEDPVLPGCKNYLRRRELKAGLLSGSIDREGYDELRREGLLSMKKGGTGGGGEATPCIKMEVNHGDLVVMTGEGLQKFFEHSVIPDKRLRFALTARYIKPEFVGVEEMEKGRLDLGREWAYDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC23</accession>
    <name>A0A8G1RC23_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fungal STAND N-terminal Goodbye domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_465807</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519886.1">
        <property type="nucleotide sequence ID" value="XM_025662087.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37165489"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031350">
        <property type="entry name" value="Goodbye_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17109">
        <property type="entry name" value="Goodbye"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fungal STAND N-terminal Goodbye" evidence="3">
        <location>
            <begin position="21"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="293"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="878"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH61964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1468" mass="168486" checksum="3D2BB2A7AF7D9CC9" modified="2022-01-19" version="1">METPSVQDPQERLKSIRRLLNEACAQFEKITKRRLEPRRFEDPRSFEELKARISSGGNGEDDASRATRQRFLTIVSVAQTWTGPIKTATDAVSISLAFSPASACVSALSYILEIPSKVHGIHESIRAVIDEVEPRFTEFKEYDDMGTAVNRVLMISVCNVMMAFITLCAQCVKLLEKGKAYQYFKEGKWILSNQNPIREGLDKLKALSEQKEYVQQMIMLKEILHSSDKIDIMDGKVDGISEYVSKRSDEITRQDELSKIQKYLRVTSEDGVMLGPRVYTETVRMAKDQKCPFLESESYKTWALKKDEGVPPLLLIFGKPGTGKSVCAASMFLNIKKKEPFAAYYSFPPMPKSPKDHQQPLEDCVRATGLQLAEQNLDYRRRLLHFLKTEDGRAQGTGYKGLLDALNVWQAPDKMICYLILDGLDNLAEQECKDFMNHLITNQIPSKRNSLRICVTGSRKLLRAYSKQKDCLQSEEMECYNQRVIADYTAKFLEKKDLLQEDFLDFADLRKSICEAVTKNARGSFHKVQKWLDRIENLVQSDSRDELIRFLSALSRGGSDLAKSELQDLERTLDWKEIAELNELIIWSEFNMSKDVILDIEQLEAFLFIRSNSPPLSSLRKKIRDRFSLILEERDDGVRLRKEMKHLIILDQNKDQQSAISATISVQNTSIEVAQRFFWDLANHSVMNRFNFDANQMDMAKPSTHRIRVTKLNAHLVIVKRTFEFLRKAPDPLSRPIGGILLRDLPAHLAILQEPSPLDDLKDIDRRTIGENVQELFLSPMSLERHWDVLQQTRWHTSSDAIASFCKWLSDDAAIKHPLIRDKIREVQKGQKQNQKLFEPLARLANHKWLQDRSPSSTTASFEWLRAFLNMNAEVDHANQVSDSSPEDDDHSLGSDDGIEDYDVKKAEKWCERVLGPSRMREQDVWVQRLAETYEYANSYKKAFKNYQKTSELLKQMGDIDKERHGEVLVRLASLDRDKDQALQYLEEALKLSDSNINARYALIKTLWSRNRKEELGKWIIGALKLKTTSGPMEHLGQVIKMAIEDYYYDTTQTMSLLCTIISICSSSADNFASLLENMQTAIENAKAQNQARTWAMLLLHKGIALACYSETSSHADQAAKAWTDCAEIILRKLKYQSAGAILLDKVGRQLGCHYFTQTLKNPDRAERYSADLEEVYQNQKGIVHGMSAAKTYLAADFIRRGKQTDAEALFQENIKEAFVLLSDDTTGNDMGGFIRLFLIFLHTGDRVNALTAFSLLAPRVLDAKILEEWLRSDEETTTPEATELREYFQNNCEKPISVWSKVSETKYFSLRSQRRLLSETDIDFPLSDDHAAKWKSYEALFESMERYEKALDEASDNYVCDECDCPLDMSTSMYACKYCFNIGLCESCHQRLQRGELKTPLCRIEHDWMRISSWDAKAHVRAFRRRVLMDATVADDGSLVGGREVPVVEWLNCLKAKWDPQGEWEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC40</accession>
    <name>A0A8G1RC40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_444747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521385.1">
        <property type="nucleotide sequence ID" value="XM_025659101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC40"/>
    <dbReference type="GeneID" id="37162503"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="403" mass="45695" checksum="0F88A6F5B337FC69" modified="2022-01-19" version="1">MDPAVEESVKRFAKDIYEYWKSRRTSNGNEPLLPTPKVEAGRDTDDTDPYVCFRRREVRQTRKTRGRDAQSADKLRRLRKELEDARQMVALVRQRELARKEMLAIERQVFLQRSEVKEMKRKLNIKDDDEDLINQKPKKKPVEAPAVQRPAAPQLRMPPKAGTQAAEDLQLLEDVQAEKENEIQRDIKQNIAKHVKWNEGYVDFTRAPLSPSPERTFDAASFRPAITTQLPTPPSSESSDNMLDSPLDTTSAIALRDKLAPHAMELSVDTSKMPSFRRRIGRGGRLWIDRRNLVSRCRVELDPWKADRFKYDQEDSDEDLEFEGDQYDIQIMQHRAIMAAKARDQAAAAAQAHAQAQAQQAQAQAQAQRRLQAEQTSATNPPSGGQTMGSNPGPGAIASTSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDB6</accession>
    <name>A0A8G1RDB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_444453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521028.1">
        <property type="nucleotide sequence ID" value="XM_025659017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDB6"/>
    <dbReference type="GeneID" id="37162419"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="157" mass="17740" checksum="90845FC366E119FD" modified="2022-01-19" version="1">MALHLEPNGLYLLLADRESSSTFHWGLCLAKSPTDGTIFNIINFPNRNVYSYEIKSDQKVISSRRYLLALKVGDLHPALHGPLETRLSQIPIQYSTRFHEAMTCRVWVKEALFALDDEGYIKLVENINGIEAEARFAAMLNKANGKRTVGKSRGYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RGZ9</accession>
    <name>A0A8G1RGZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_387192</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521067.1">
        <property type="nucleotide sequence ID" value="XM_025656661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RGZ9"/>
    <dbReference type="GeneID" id="37160063"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000296">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF74">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="57"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH63145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="539" mass="59150" checksum="39F576022AD35C9A" modified="2022-01-19" version="1">MATKMSSIPTDNAALTRTAQAVAAGEVEQQSWLERKLKPTKVRAWYPFKGTPLLYATCGFGSLGDALFGYNSGIMSGLLVNPAFVARFFKDYGGADGSTTGVDPSITGIAVACLQASAAVGALLAGRLGDMMGRKRCVRLGGFIYFFSAFIQIFAPGFGTFIAGRTIQGLGVGFLSMTVPIIQTEIAAPRRRGLMVGIEYTFQIAGYMLSCWVDYGFNFLLPSEMSWQGPFIIQIALSFVLLAMSFFLPETPRWLAKNGFMQESLQTVADLHANGDTQAEHVQQVFVEIEEAVIFETNLGKSSWMEMFTRYRKRTIVGITVQMFAQLNGINIISFYLPSTLATAGFDERKSLLYTAANALPYTAATISTWWLADRWGRKPLLILGGLGMAVLLGIVCAFTEADLDVQVRAKGQYAFVMLYNILYGFTWGPMPWLLPAEIFPLRGRSKGMALATTSNWIFNFIIGMVSPDAFAGINGYFYLVIAGFCLFSAGLVYFYYVETANSTLEEVAELFGDTAFADADGEAREASEVRIDYRKDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RH68</accession>
    <name>A0A8G1RH68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_444551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521172.1">
        <property type="nucleotide sequence ID" value="XM_025659038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RH68"/>
    <dbReference type="GeneID" id="37162440"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="173" mass="18722" checksum="CD56380B52FAEA27" modified="2022-01-19" version="1">MNFTIINGQIYTPGLAIIDAPQPYTPLGGDTLQIAIDTSGDGQLTSSSSSSSSTAFHTLNLFLTSTTTHKNLTISNGTTPSANNTYVGPVLDLEPSSTVKHVNWIWPACFVGSGGDKSPRGDYNISVHQGFRWEGTDYYTVFELPISVTNAIGKVRKGWIVRCWRMSGWGGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIB9</accession>
    <name>A0A8G1VIB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_381293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="77"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="251" mass="29113" checksum="092C49431A6655A7" modified="2022-01-19" version="1">MTKSQFEVREIHTKEEYARLVDVLWSANFNPYNPVFTAVHPVSGHTAEDRVKDKALDTEIRWAAHEKNPASHLIYVIDTETGRVAGGCEWLIFHKNPFPNGPQPLSCTWYPEGSERAEYASRMLSQAFFPRQCWLQRPHAGVNAMGVHPDYRRRGVGRLLMQWGHERIDPLGYESWIEGSPIGRWLYEESGYKRVISLNIDFAKKNPSDEWNRLVHECQPPAILLLWRPPRGEWNDKVPPGPWAVTEDTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIE4</accession>
    <name>A0A8G1VIE4_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_452638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000249526">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="53" mass="6284" checksum="729FD2DB342CECC3" modified="2022-01-19" version="1">MNIQLPYKQNTGLKMIFRRFCPSISVRGFYFLSVVLLWLCIAFIPKLLYRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIX4</accession>
    <name>A0A8G1VIX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_522406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_025665258.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="37168660"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="21"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="122" mass="13253" checksum="74988D98490E7193" modified="2022-01-19" version="1">MSDYDKVRIAYDAEKDLNSYQAKQGLGPKSDSTLESGVNEMVDRKFETGIRTGREAGASGSDRKPIPEEEGGSRDDRGRLAKAGQFNGPGGPEDKVKLESERRPGDQDTLGIQDLKREGLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ74</accession>
    <name>A0A8G1VJ74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pheromone-regulated membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_103507</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512332.1">
        <property type="nucleotide sequence ID" value="XM_025653794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ74"/>
    <dbReference type="GeneID" id="37157196"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF11">
        <property type="entry name" value="DUF1212 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="580"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="625"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="229"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="506"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH54410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="663" mass="72645" checksum="E549E756990CCF06" modified="2022-01-19" version="1">MSSPVDESKTHLGPPRRDTDPSSDDDRLGNRSTNNDERPLTRENPPPPAGGNQWGVLFKAIRDGTSQLAEKLGRDPDGGDGLDSAWHPEDYGFQEDIEMREMLAEEELEDAAYASKLQSVLGSDANNLVKNLGLGETPSRTNSNDENLVGGVLWHLLSHQMGHNPEEIHDDGAIPASTEDGLAPLPTDLRKRRKKKWYEEDPTNDKEGRRKMKEELLTQKIGSLLTRQRYMIQLCRALMKFGAPTHRLEEYMQMTAYRLRVNGQFMYIPGCMIISFDDPLTRTAEVKLVRTTHGLDLGRLGDIHNCYKNVLHGRLTPDEALPVMDDLLTRKSRIHQAWLLVLLSGFASVAVGPWAFSARPVDMPIIFVLGCLLGILQYVLAPRSALYSNVFEVTVAMLTSFLARAFGSIYYSNGEPIFCFSALAESSIALILPGYSVLCSSLELQSHQIVAGSIRLVYTIIYSLFLGYGVTVGLTIYGLMDDNATTATTCPSRDTNIYGSVYVQEFVFVAVYCAFAAILNQAKWKQLPIMSFMGVAGYTTNYFTANHLDSRFGSTIGAFTIGLCANLYSRVWHGHAAAAIVPGMWTLVSSGLASSGSIISGLAYAEAVKNNTVSDSTTTKTQESLGGLALTMVQTALGITVGLFLSAMVVYPGGKRKGGLFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ99</accession>
    <name>A0A8G1VJ99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_404163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511989.1">
        <property type="nucleotide sequence ID" value="XM_025657261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ99"/>
    <dbReference type="GeneID" id="37160663"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF668">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="51"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH54067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="459" mass="49501" checksum="E81D03D72D0968B1" modified="2022-01-19" version="1">MSTLDVKDIETGPGRRVEEDGGMWENDIVKTPSVEKDPFGNEAVGEVHYKTLDWWQSGMLMIAETVSLGVLSLPATVAEVGLIPYAISAIILIVGMGIIATYSGYVIGQFRARYPFIHSMADAGEVLCGRYGRMFTEFAQLVFFMFASGSHLVTFTVMMNTLTNHGTCSVVFGVVGLVLSFACSLPRTMKNVSWLAVTSFISIFSAVLITMIGVAVEHPHPAPMQLTRSTSFVKGFSAVTNIAFAYCGHPAFFGFIAEMKDPKDFPKSLCMLQGFEIVFYTVASAVIYRYAGQNVTSPALGSAGIVVRKVAYGIAIPTIVIAGVVLGHVAIKNVYVRLFRGTDVMHKRSALGVGAWIGLAAGYWIIAWVIAEAIPVFSDLVSLVSALFASWFSFGLPGVFWLYMYWGNYFTSVRKTLLTLANLALFGIGATICVCGLWVSGLSISSDSSGSSFSCANNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK80</accession>
    <name>A0A8G1VK80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_50760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514386.1">
        <property type="nucleotide sequence ID" value="XM_025664412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK80"/>
    <dbReference type="GeneID" id="37167814"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH56464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="218" mass="24691" checksum="7EAE494D1C175DD0" modified="2022-01-19" version="1">MIMIALSLSRSLDSMLTVPLADLGAMIERTGRHPSPTPSPPVKLERNELLGVRSLLVGIRRRNGSMTGVWIYTLELDGSFELLHLQKWRRFYMKGPLNSQVVWPSDGSQTKELGASVQSVSVFFSFSFFFFILLRIEPGSQPSVYTFYFFPVLSPAEVRILASVLAFVADEAKNHPWRHCGNILQGVSKYQESRATGYLFPKEATRLFTRVYQAVPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKI9</accession>
    <name>A0A8G1VKI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonucleases P/MRP subunit Pop8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_42003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514746.1">
        <property type="nucleotide sequence ID" value="XM_025657884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKI9"/>
    <dbReference type="GeneID" id="37161286"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020347">
        <property type="entry name" value="Pop8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049128">
        <property type="entry name" value="Pop8-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20976">
        <property type="entry name" value="Pop8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonucleases P/MRP subunit Pop8-like" evidence="2">
        <location>
            <begin position="36"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="181" mass="18208" checksum="F55D63CFEE047986" modified="2022-01-19" version="1">MSTTTTTPSKRKSSTTTTSSSSTPKTIHFTSRTPTWTYLKLQLINNPPTTSTPLDPLTARTYLSAALSQFLGLTGTSIPIDILKISPPRPSWASSSTSTGGKGAGLGSTVWTRVPRDDAAAVVAALSSWIGGSASTATNTSGAGGGDVGGGGGGSVAWRVCAKGNHLGALVNGNGGEVFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKJ2</accession>
    <name>A0A8G1VKJ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_83744</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513279.1">
        <property type="nucleotide sequence ID" value="XM_025665718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKJ2"/>
    <dbReference type="GeneID" id="37169120"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH55357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="32026" checksum="9E592CB8CF696350" modified="2022-01-19" version="1">MAGARLDDRQSEERLISSFDEENFLKDSRSPGARRSRWCWYHPNGTLILSLWTLFLFIASIYLWSTVARHRKTAAACQCDDYLPIDSPALEALENTGHIEKFDGSFAKPNAFKGPPSPAIDAAWDDITYASGGVINVDEQTLQQINASEYSVGLADELGGGYMGSVEVLHQLHCLNMLRQASYEDYYRDKPGPWEDSPQILRHHLDHCIDILRQKLMCDADVGILTYVWVKGHKDPFPDFNVHHKCRDFRAVKQWVGQHQLYTTPEHGIERLPGAKEMPSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKT2</accession>
    <name>A0A8G1VKT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tautomerase cis-CaaD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_491744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH54023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511945.1">
        <property type="nucleotide sequence ID" value="XM_025663734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKT2"/>
    <dbReference type="GeneID" id="37167136"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="147" mass="16818" checksum="2BB46F4142EF1BC1" modified="2022-01-19" version="1">MPFWQIFHPSGTFEDTASKKALTEDITKIYTGIGLPAFYVVINFMKLPPGDTWVGAEIRTEKPFIRIIADHIAVRLENDDQTYKSTCDAIDKALKPHIADRGYDWEFHVDETERRLWRVNGLVPPPFGSDAEKIWAKENKPVAWEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL48</accession>
    <name>A0A8G1VL48_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_468868</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515361.1">
        <property type="nucleotide sequence ID" value="XM_025662300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL48"/>
    <dbReference type="GeneID" id="37165702"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH57439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="480" mass="53236" checksum="D51B6AC1AFCAA4D3" modified="2022-01-19" version="1">MALRPCKVIIAGGGVAGLSLALMLEKHGIDYLLLEAYPQVLATVGAGIALAPNGLRIIEQLGCYEDLQKYSAGADQVHFRKPDGETLWGMDEGLAETCIAKCVPLACLLPQLLNEYAYQGDRHGYTYMWMDRKSLLEVLYNNIADKSKVLPGKRVASVTHTDNGVDVVTTDGSTYYADIIVGTDGTHSKLRQEMARYAEDLGLSEDYAEEDKVAATYSCIFGMSDPVPGFPSRSLEFVTNEGFSYVLGAGPAGRVYWFLMEKMKQTYYGADIPRFSEEDKQRTLQEHWNDQVTPTVRLSDLCKRQLSTIYTPMPEFVYKKWHLGRIVTIGDACHKLAGSVQVLPTTAQGGNQALESAAAVVNGLMTALSQASGSGPLSQSEIQLMFERVQNIREPRTFSIIETTHKRQKLDTMDTPELKEFLLTRYAGLMPGELWKRWAHTFTPAVSLDMLDLPARPKSVPFDDEALRNKDSNKALEAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMM9</accession>
    <name>A0A8G1VMM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclohexanone monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_518884</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516936.1">
        <property type="nucleotide sequence ID" value="XM_025665001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMM9"/>
    <dbReference type="GeneID" id="37168403"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF5">
        <property type="entry name" value="DUAL-FUNCTIONAL MONOOXYGENASE_METHYLTRANSFERASE PSOF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH59014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="548" mass="61911" checksum="3581F384DF79C1A2" modified="2022-01-19" version="1">MSHEYCLDALVVGTGFSGIYTLYTLAEEGLAVQAIEKENDVGGTWYVNRYPGALSDSWSHVYRYAFDEELLQTHPVVRRYSTQPEILDYLKHVVEKHDLRSRIHFNTEMVAARWDGIAKEWRVQCQTGDVYRVKYLVTAVGVLVKPKVPDIPGLKGFKGRVVHTAAWDPSIHVENKRVGVIGVGSSGVQVVTAVASKVKSLHVFIRTPQYTIPANDRQMTPEEQKSMDEKFPQVWSDVLTSRLGMGFLEHDRPFMSVSPEEREKILEHLWRDGNGIQMMFAEFSDIAMDAVANEEVCRFLRRKIAEIVKDPEKQAVLTPKEAWNRRPLSDAGFYEQFNRENVYAIDIKKHRITEATAEGICTSDGRLHELDVIIFATGFDAMDGTYAQIDIQGREKGETLYDRWKRTGPDCYLGCSVAGFPNLLTVLGPRVAFGNVPPLLEIQVSFLRDAIRRAQDITRHTGKQCEIEATGQAEREWTEVCEQIAKMLLFNRRSSWMFRKNVPGDATSSLFYFGGLGAFRAKLKDTKVNGFSGFKSPLGPAAEARAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMS4</accession>
    <name>A0A8G1VMS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein farnesyltransferase subunit beta</fullName>
            <shortName evidence="9">FTase-beta</shortName>
            <ecNumber evidence="2 9">2.5.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_487868</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="2 9"/>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515977.1">
        <property type="nucleotide sequence ID" value="XM_025663485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMS4"/>
    <dbReference type="GeneID" id="37166887"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02893">
        <property type="entry name" value="FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000014">
        <property type="entry name" value="Protein farnesyltransferase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="11">
        <location>
            <begin position="127"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH58055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="523" mass="56951" checksum="C7E4E8DC190C1701" modified="2022-01-19" version="1">MPIVIAAAGKPRRKVRFSSNQTSRPTDAQGRDTKSTSSSIGRRQPSAPTSKKHTSLDQRSNSSGGMYEPQAHPGVPALFQELPSLLDALCTESSEVQSETVTKCLPFLKGIHNSQAGPFNRFGVPALNQNDHLIYLYDSLEDYPEGFAGMDASRPWMVYWVLAGLSLLGEDVTKYRERVVSTFTPMQNPTGGMGGGHGQLSHCASSYATVLALAMVGGEEAFNLIDREAMWRWLGSLKQPDGGFRVCAGGEEDVRGAYCAMVVHSLLNLPLELPPDAEARQHGLETFTSGLSEYLSRCQTYEGGISGSPGSEAHGAYTFCALACLCLMGPPEVVVSRCMDVPLLLSWLSARQYAPEGGFSGRTNKLVDGCYSHWVGTCWPLVQSALNGVQSATGPERVPANLYSREGLTRYILGCCQSKYGGLRDKPGKHPDSYHTCYALTGLSSAQYHHYHTTSSISSDEGFGSAYSWKCTPIPASDDASSDQNVFDEKDRLKAFHPIFVVPHAAAENLRVWCEQRPIKPEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMY2</accession>
    <name>A0A8G1VMY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_467967</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517251.1">
        <property type="nucleotide sequence ID" value="XM_025662223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMY2"/>
    <dbReference type="GeneID" id="37165625"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="554"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH59329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1049" mass="116951" checksum="E7639017DAB4282B" modified="2022-01-19" version="1">MAPNIPVPRKRLLTTEIDAIAESNPERRFCVMPRGSELSDGLQEISIKALSRGINFLCWWIEAQTGIDAPVGSTVAYMGANDIRYFIFIVACHKTGYKPLLLSSKNSDEAQLYLLHETKCNRFFYTAERERKVAELKQLCPELNIIELPRLDAILKGQEGSRFYPFTQSYEEAEDEVFLIVHSSGSTGMPKPIALTHGYFSALDAIVHLPRPGDRRLTIFCDLSPDNLVLSVVPFFHMMGIVAFTTSIFHSVPFLYGPEKPLSVDFLTDLIKFGRPTTALLPPSILDDVSLSEEALLTLGTMESVYFGGAPLSSETGDKVRKYTKLITALGSTETNLIPSIVPEKDEDYGYLEWNPNYGAVMEPVGDDIYELVIPRPTTRDYHGICHTFPSFTEYHTKDLFTRHPSNPRLWKHHGRLDDVIVLSNGFKFNPVILETMIEAHPLISRALVVGKGQFHTALLVEPYWDAFDSYLDPNSFIDDVWPAIEEANKTIAAHGRIMKDKIALSKRDKPFQTTPKGSTRRAAVVKDYANEIDAIYTMSDEGTLAVDELPANPDLSNLSEYIHDLVTKTLQRSGFGPQEDLYKLGLDSLQTIQVAKYLRSALFAHCGGPSAVELTTQMVYANPTVEKLAQLLLRVLNGDNATDVSRPEKLNSLTEKYTSSLPIQASMTDQTTKAPTKSPIILTGSTGSLGTYLLHTLLEDPSIAKVYCFNRSDAQSKQETIFQQKGLHIIPNALEKVEYLTVSFSDPHFGLPLPKYNALLTTVTTIIHNAWKVDFNHSVDSFEDPHIRSVRHFIDFSLRSTHHAHVHFISSVGTVGAWTWDMGSTIPESPLEDSKACPSQGYGESKYISERICHEASRRSGVPTTVYRVGQIAGPTTIEGLWNPKDWLPTIIKTSKAIGLVPGTLGSRSVDWIAVDTLARIITEVIHTRAVTVSSASPHAVFHLVNPSKTTWEALVPTVQDMYPDMEPVGFTTWVKHLEKLSMKSPSEQEIAEKPALKLLEFYREFAEGATLLVPLEVDRAKEASETMAALGPVTGDDMRNWLKQWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN21</accession>
    <name>A0A8G1VN21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_438335</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516054.1">
        <property type="nucleotide sequence ID" value="XM_025658664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN21"/>
    <dbReference type="GeneID" id="37162066"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07500">
        <property type="entry name" value="HAD_PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.210:FF:000001">
        <property type="entry name" value="Phosphoserine phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000143">
        <property type="entry name" value="Phosphoserine phosphatase serb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01137">
        <property type="entry name" value="C1.6.1:_Phosphoserine_Phosphat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01136">
        <property type="entry name" value="C1.6:_Phosphoserine_Phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH58132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="469" mass="51597" checksum="33B4C5C454C424DE" modified="2022-01-19" version="1">MAAPNPTNNGRPTRPVLRQTLSSASFIQDHQQYKPSAPIQTIGNVIGNSPESAFAALSVKANPISPDPEKVTDSGIIHSIFNQQSNELPTGTQQLVATIYYKSADPIHPHLHPDSSPHVGSGQTLPSPMVPVGSAPTVDIEKIPREPPAPEPEPLDHLYGPFVSQLCLTNFLQIIETLPTPYQRTNTSHRCLDRHDQPRVVEVTFSPPPNPEYLTFEDLRKHESIWRFEREWNVEVVLQRESVFRRHKRLVVFDMDSTLIQNEVIDEIAKFIGVEKEVSEITARAMNGELDFSASLRERVSLLKGVPADVFEKLKSVITISPGARELCKALKTLGCKMAVLSGGFQPLAEWLAEQLGLDYAHANHLEIDPTTQTLTGKLVPTYPIIDASQKRSILHSIAAEHGIPISQTVAVGDGANDLLMLHAAGLGVAWRAKSKVQLEAPTRLNGESLVDILYLLGLTKDDISELIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN88</accession>
    <name>A0A8G1VN88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Arylsulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_369835</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516442.1">
        <property type="nucleotide sequence ID" value="XM_025655938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN88"/>
    <dbReference type="GeneID" id="37159340"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000051">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034776259" evidence="12">
        <location>
            <begin position="20"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="665"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="719"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="766"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="13">
        <location>
            <begin position="32"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="765"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="769"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH58520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="820" mass="92781" checksum="08E65B1F9D94E5F6" modified="2022-01-19" version="1">MRSLVCLLALAGFTAQSLGQQQQQPLYATAKPNVVFILTDDQDAQLGSLDYMPYVKKHLLDKGTHYRSHYCTTSVCCPSRVTLWTGKLAHNTNVTDVNPPHGGYPKFISQGLNDNYLPVWLQEAGYNTYYTGKLFNVHTVDNYNAPFPAGFTGNDFLLDPFTYDYLNSTFQRDREPPQSYEGEYSTDVLGQKAYRLLDEAVTAQKPFFLTVAPIAPHCNVFMNGTGLDANPNFSFSAPIPAKRHEHLFPDVKVPRTPSFNPENPSGANWIKTLKRQNDTNVDYNDHFYRQRLRALQAIDELVDGLFTRLKEYDILDNTYVVYSSDNGYHIGQHRLQPGKSCGYEEDINVPLIVRGPNVAQNVSTDIVTTHTDLAPTFLDLLGIPLREDFDGDPIPFTESQIEEAHDERQEHVTVEYWGYAAGEGIYDCAYPTHTLHSLTVHVLIRTLKVDLSAYNNTYKALRIRGNEYNLYYSVWCNNEHELYDMTSDPHQLHNLLSTNGLPNATSHIILNVDLSKVVQRLDSLLLVLKSCKGQVCVKPWDALHPRGEVTTLKDALDVRYDYYYEMEQTTRVQFDECARGYFLDVEGPQFGQGTEYGVLRDGLPCIIWDLRSPAAPQQTPNRVALNPILRIDWPDELSMHLLTTPLLYRILSFQATPQYTKAVGIVLSVLFTIVMVVHMVMDEFLLHAVTFGTAVYLIATRTLKIIPREIPDVEDRKRIQNVALFGCASFIFGYLVWLVDEWVCQSLIGARHAVGLPVAFLLELHGWWHVFTAIGGYIAVAIIDLITSGQLQRDSVAQLAWPLPTVARLLGPAEGEMKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNI3</accession>
    <name>A0A8G1VNI3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Alpha-galactosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_513126</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="4 10"/>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516742.1">
        <property type="nucleotide sequence ID" value="XM_025664688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNI3"/>
    <dbReference type="GeneID" id="37168090"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000286">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF87">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034377435" description="Alpha-galactosidase" evidence="11">
        <location>
            <begin position="27"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="12">
        <location>
            <begin position="335"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH58820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="408" mass="45223" checksum="ABE0338D3F71B392" modified="2022-01-19" version="1">MGRNYQHLSFRLAVVAILTFVHSVLGGNSLAQKPQMGWNSWNAFKATVNYTIVQDVIERFYTLGLKEAGYEYVLLDDGWASYNRTSDGYLQANATSFPQGIKALAEEVHAEGLKLGLYGDSGHYTCAWRPGSWGYEERDAQTFAGWGVDYLKYDNCGGFQSMMEAPQIRFGAMKNALALSGRDIFYSVCGWGYQFPWHWGGDIGHSYRMSGDITTSFTNETECQCKTAYCLNTGYAGCSVLTIINKMKEISQYQTQGHWLDMDMLEVGNANFTLNQQQTHFAFWAALKSPLIIGADLSKLSNDSLGVLTNTAIISVNQDALGEPVTYREAHSKEGLFQVWAGNVEAGYVVLLLNEKSYPQTVSLSFASLGLGSPQKVVELWSGKTLQVANTFNGTLGSYQTLVFRVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNI4</accession>
    <name>A0A8G1VNI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_488913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514660.1">
        <property type="nucleotide sequence ID" value="XM_025663569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNI4"/>
    <dbReference type="GeneID" id="37166971"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02118">
        <property type="entry name" value="EthD family reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40260">
        <property type="entry name" value="BLR8190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40260:SF2">
        <property type="entry name" value="BLR8190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12772" checksum="A80E2C2A26E255BE" modified="2022-01-19" version="1">MVYTVTVLYPNEADAKYDLEYYLSHHLPLVDRLWRKYGLHGWTVVKYGPGATEDRIPYSFGCVLFYEDDNAAKQAFKGPEAAEVLGDISKFSNKQPLFLYGERISTGGSVGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNZ1</accession>
    <name>A0A8G1VNZ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2,4-dichlorophenol 6-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_35745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515140.1">
        <property type="nucleotide sequence ID" value="XM_025655496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNZ1"/>
    <dbReference type="GeneID" id="37158898"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH57218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="576" mass="63947" checksum="FB31DF5E96D2C78F" modified="2022-01-19" version="1">MSSPETYDVIIIGGGPVGLLLAYQLTRFELSVCIVEKQDKDTPEGRYGRAITLFPRTLELLDQLDLVQPMLQQGFACRSSVTYKDGVRQFPGKVWTFMENIQGTVFDFALVLRQMYTEDILRERLDRGKVTYHGSMECVGFETGLDDSEYPVTVHCSGPGGMMSAKSKYLVGADGGHSLVRRYANIPFDGDSSEDQWIRIDGIVETNMPINRAYGAIETTTHGNVLWAPLDHGATRIGYAYTPEIAAKYPEGVTEEVAVNEAIACLWPFSLKFKEVHWWTLYKIGQRMARTFATHNNRVFICGDAAHTHSSGAAQGLNTGINDAVNLAWKLALEVQGLSHPEVLDTYTTERQSAVQKLLNYDKDISLLMTHKWPAWYDGDPHADPNVLLGEIFNNAAPFNTGLGISYEANVINQPWVSSTEAAVGVQPGTRAPDTELTTPGTFQSVRMHQVLRNRCQFHAIVFTGGDIKTAKSDLVPLREYLDSHPELAMHPAIAWLTVCGSAGCSPYEVLGMTGFGDTYFDARGIAHYAYKLYSRKAMLVVIRPDGLIAFTCALDGETIWQRFSRILKSQPQKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP91</accession>
    <name>A0A8G1VP91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SRF-type transcription factor RlmA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_457541</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518661.1">
        <property type="nucleotide sequence ID" value="XM_025661527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP91"/>
    <dbReference type="GeneID" id="37164929"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000013">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="561"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH60739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="623" mass="66565" checksum="8B7225A1CEFC02F5" modified="2022-01-19" version="1">MGRRKIEIKAIKDDRNRSVTFLKRKGGLFKKAHELAVLCSVDVAVIIFGHNKKLYEFSSCDMREALTRYQYFGPPHEHKGPEDFNGKRDDDDDEDETTPAPEDVHPTPPNPPMIPAHLPGHPGFQHVTHAPSASPPIGNGMFAPRHGTPQPQGVSRPSSRNHLRRVSSNMGPQQHHHATPPPPPPPPQNGFTYIPNPSVYNPNAAHAMAQPPRPPQFTHYGPPGPHHQPPPPPQHHQAMPPHSMPPQPMPPHTMAPQAMPPHHQAPPHMPHPPHALAQQPPPMAMTQPPHAAIPQVAQAFLPDQGRNSMPPAFTTDQQPPPPRTVSLPEGTAPTEAMPGPMKTEGTPSPPHQRSLSSKSRSIFTPIDDRGSVLARHFGVGPPTETGENAQTRAEGPAHGPNDGKPAGLTAKPPPPPPRAATEAPRPQPVVDLKPPVRTNSGQFPPKRPQLKVQIPSENSDRGSATADSSSRDSAGNKTLTPAKANPDTGHSSVVLPPPSPSAGAILSAGAQGPPNPFARPPPPGAATQNNSAYNNNSNIDTPISALPSRFVSDALLPSPSSFFPEWGFGRSGPDSNMLPSPLTFPTPAVQSGPGFGREDEQDRKRKSPDSGPNAEGVLKKPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPB3</accession>
    <name>A0A8G1VPB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_485955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517404.1">
        <property type="nucleotide sequence ID" value="XM_025663356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPB3"/>
    <dbReference type="GeneID" id="37166758"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="15"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH59482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="174" mass="19549" checksum="D5743A916AFF9E1B" modified="2022-01-19" version="1">MHDYLGHPLGLVGWFARTIQAISSIIVLGITAWAVREDNKTLSVIFSLVIATTSLVVIAVAVGISCLARRAKWHIIPLLVTDAIISYLWLTSFILLALNFNRRTCRVNRWIGEVSCSRSYTAEAFSFIAFFTTLMGLFLETAYIYWAKPDSVPRTEKRLHQERLSENLNAAGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPG8</accession>
    <name>A0A8G1VPG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 17">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_176849</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 17">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 17"/>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518693.1">
        <property type="nucleotide sequence ID" value="XM_025654329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPG8"/>
    <dbReference type="GeneID" id="37157731"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04824">
        <property type="entry name" value="eu_ALAD_PBGS_cysteine_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH60771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="374" mass="40601" checksum="F79DFF5A051208B6" modified="2022-01-19" version="1">MSFSNLVSDLAFRDAQDDRSSQISHARSQATARSYTSTAATSVSISGDISSQLHSGYSHPLSRSWQAEKQLTKEMLIYPLFITDNPDEETPIPSLPNQYRRGLNRLVPFLRPLVQKGLRSVILFGVPLHPSAKDALGTAADDPTGPVVQAIRLLRSRFPQLYIVTDVCLCEYTSHGHCGILREDGTLDNAQSVDRISDVALAYAAAGAHCVAPSDMNDGRVRAIKLKLIEAGIAHRVLLMSYSAKFSGCLYGPFRDAAGSCPSFGDRRCYQLPPGGRGLARRAIQRDIGEGADIIMVKPASSYLDIIRDAKELAKDMPVAAYQVSGEYAMIHAGAKAGVFDLKSMAFESTEGILRAGAGIIVSYFVPDFLDWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPM2</accession>
    <name>A0A8G1VPM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_446301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519051.1">
        <property type="nucleotide sequence ID" value="XM_025659472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPM2"/>
    <dbReference type="GeneID" id="37162874"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="397" mass="43105" checksum="5E68811742568A0F" modified="2022-01-19" version="1">MEDASDGKGAALSLDNNDQLSRRVRSGSASSGHKRSSSGSLLSRLSFLRMIQATQNAPERSHSGIERDDTSDFSSGLRGGRAMSTAIQQHRRTRRRRGSLRKTALLGTRFEYRDKKLPRPSVDVLRGDDISPNGQPSLPGGSSTSPLPPSDSQLRAFADPTSPDNGTVLQQSSSGHRTDRGGNTSTWTLMDAPQRTRNAAAPSHRQQNQSKESILGDEMTTDDEDIIPFPHPNTSNSAIAAAAAAAAAAATTTTGLHLPTASSNSDSYYALQADSTAYRPLHRAKSPLATHSADIVSTSEMVWDYSETEWWGWIILIVTWLVFVVGMGSCFGVWSWAWDVGETPYAPPELEDDPTLPIVGYYPALIVLTAVMSWVWVVVAWVGMKYFKHANISGEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPM4</accession>
    <name>A0A8G1VPM4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_517183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518873.1">
        <property type="nucleotide sequence ID" value="XM_025664889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPM4"/>
    <dbReference type="GeneID" id="37168291"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="481" mass="54719" checksum="A567715D41CD2D59" modified="2022-01-19" version="1">MGKRKEVKAPSSKASSPPHVPDDTNPAPTLNQSERYKDIDALQVKIDHLQAEIDELERDRQEKMRLAVFGGRGWPKPIIDYKNAFNSLFITANWWADDYVKRDTAALAEFAPGEKRSILQSLVGYCVQDLDWDTFLKSLPYPIRTFIPLVLARTMLVKDIFDKVFENPFLSSLSFAQHLQHLYEQFLIVNPKSASLWKTETVRLANSVNDKQANNTEMGRHTKSRREGLTRSFASAMLKHPPFQMLLENCEDTAVREEKLVQFYEKAEKLAISLGSSHGICTYRNLTKLASPLFSGGDQVVTAEDRHILLPHQPRLDGHRILFILQPAVSRTGAAILDGGLESWAQAVAVIEDGDCTEEVYHELQQEREAEAREVYREKQEVMAKHQAEWERERREKQKEGKRVEEETQGEEVGKIIEGSPGKQEDDEGADEDTERPAPKRARRTRGAAGKKSGQQVEEEKGEEETKKIRGRRATRGKTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR16</accession>
    <name>A0A8G1VR16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RBP11-like subunits of RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_445842</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520343.1">
        <property type="nucleotide sequence ID" value="XM_025659363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR16"/>
    <dbReference type="GeneID" id="37162765"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH62421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="129" mass="14455" checksum="7C5D90DCEE433894" modified="2022-01-19" version="1">MNAPDRYESFVLANGENKVEMEIDTRIPSSAIFTFNKEDHTLGNLIRSRLLQSSHVLFAAYKVPHPLVPNFQLRVQTDGDVSPKDAVIAACHELVRDLGILSREFTKEYELRKMVGATAQQQNGVQDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR44</accession>
    <name>A0A8G1VR44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_446601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519369.1">
        <property type="nucleotide sequence ID" value="XM_025659541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR44"/>
    <dbReference type="GeneID" id="37162943"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH61447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="330" mass="37319" checksum="5E943FF29AFF43ED" modified="2022-01-19" version="1">MYLCSANYIGDPSRFWEQCSKCYSLIPGLFLSFLTTIPTENATMVTPQLVQITLSDEERATKKLSSHNLQAALEGLHRDGVCVITNGVDPAHLDKLNERMVPEAKTLYANPQTHRNFGSRTGNIQQEPVVDPNYMFEDVIANPWATAITECMLGPNPHLRFYSANTAFKAEDRQPVHVDVHFDFPKIPFGLCINVNLVATSPENGATELWPGSHRDADPRDSDDTGVIPEIVEARRKISPPVQPSLPKGAIIIRDFRLWHAGMPNRTDDPRVMLVTIHFPAWYRSDLKVILPRSLQGKVDWGHLIPCVEWVDEDYDYLKGRHDHDFTLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRM6</accession>
    <name>A0A8G1VRM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MYND domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_445447</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519954.1">
        <property type="nucleotide sequence ID" value="XM_025659260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRM6"/>
    <dbReference type="GeneID" id="37162662"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF273">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN SAMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="215"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH62032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="556" mass="62114" checksum="98B35A47A8576AC0" modified="2022-01-19" version="1">MQALQDRADVTARLFADPHNPHLYYKRGLVHQTLGFPDLASADAYRALSLLDSVVDPDGCEFHATRRIQDAPDAPAATGEDDDDEEDNFTPITQDEYDSIIGDVYALLVRSLVDCGCFRDAFEFCVRGQGLLEDMPQNERNVSAQAVLKDQLAIIRKNYEARQGTTTGDANINPSALNAQGFARRVLYPWNEHEPDRKSPETLQLLNERLKTVAPKCEVRAVALPALHGTTTTTTEDEVSVQLGLFAKEDIAPNEIILRESSLLTATNRLHDDLCDACNAPLPDLSSPNPPVACDGCADTIFCSQACHDDAQRIYHGAVCGLMENLESIGKDIPDPKDKADYLYLLLLGRTLAMAATQELHPLDLPEVKYIWGDFHDLDLNDTNTTSEDPTATLPFSFQLNILQPMRLLEEMEIDPYAALPRFDTWVLNTLYAKFRGTASGRLSTWDGGPELCAVHPLWCLANHSCDPNVRWEWGGEITFRAREESERAVWKRVKGEGESVPEGIRRQEAGIKKDEEILNHYCDIGLDVKERREWARGALGGWCLCERCVWEAGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VS91</accession>
    <name>A0A8G1VS91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AflR-like C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_455658</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521618.1">
        <property type="nucleotide sequence ID" value="XM_025661401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VS91"/>
    <dbReference type="GeneID" id="37164803"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF26">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH63696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="484" mass="54562" checksum="FBEF943DEC444337" modified="2022-01-19" version="1">MNEHPHPLPKSVKVRSTCNACQQAKIRCSHEKPACRRCQKHNIDCVYSISRRLGRPAKKKDVDAESDYRRDREFLDGPRKQESRARNGSKNSNSNTSSNNNRKKKMKSEDEQETVLDDTLLLLDKAGGSQSVLDPVGVLDSVPSLPGDCFLDQATPTALFADSGFDLFSDSWVQEFIANPPVDLAQEGLLLDSIHTSTSFIQDTPLIAATTLENIHGIMEAPSEAKYLKEDPLAWSLPFSTMDTFPARQIATETTAFAQAKMTKRPYLYGLPAGEMKPVSAVLAPHAYQFQCHEYTIQESFRQMSIAIRMGPYMSIDHILHCQRMLLNVSDTILKCCVCCITKRDILMVIVVNIDSLMTNLEAITTGEAGNPQRLLYNGYHEHMLPDCKQDIAGNMSRRYRSSGLHFRSQIDACPLVVGKFCVQSGDKFFCILQILYSQLSDLLSTVRRITLYTQESSTRISLTNETERRLEEVMLQMKRMTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSJ1</accession>
    <name>A0A8G1VSJ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_14439</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520912.1">
        <property type="nucleotide sequence ID" value="XM_025654098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSJ1"/>
    <dbReference type="GeneID" id="37157500"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000003">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000488">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH62990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="333" mass="37491" checksum="F632727AE86E9267" modified="2022-01-19" version="1">MDMRKKKRKVLLMGKSGSGKSSMRSIIFSNYVAKDVRRLGATIDVEHSHVKFMGNLTLNLWDCGGQDAFMETYLASQRGNIFSDVAVLIYVFDIESREVERDLDTYNAIINALKEYSPNAYVFCLVHKLDLIQAEHRQRIYEERSALIRSRSEHFSIDTFGSSIWDQSLYKAWAGIVHKLIPNLTVIERFLQAFSKRIDAEEVILFERSTFLTVTSVSSEVGDLNPIYDRHERLSNIMKAFKHCAARNTHTTPASAGFVVMHTKTPQFNVFLGRFTDNTYIFLVVPPGEAAYNCAVLNTMLAREGFSKAAATGHGDGFPLPAAESPDNSNGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VUM1</accession>
    <name>A0A8G1VUM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosylceramide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">UDP-glucose ceramide glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">UDP-glucose:N-acylsphingosine D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_14256</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520900.1">
        <property type="nucleotide sequence ID" value="XM_025654082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VUM1"/>
    <dbReference type="GeneID" id="37157484"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="543"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH62978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="557" mass="62503" checksum="8C5F753CA843C644" modified="2022-01-19" version="1">MLEPQSRSQPPDAKPAINHGGWQWAVAAGWVGLIWYTVVVAVCMLGYLQLWRFYLRKPRKSSSASASNAPHVTAIRPVKGLEPHLYECLASTFRQDYPRDKLTVCFCVSSRSDPAYPILQKLVSDFSQFDVRLYVEDDDPLLQPGHVPAYDLGPNPKIRNMSRAYREAEGDIVWIIDCNAWVGRGVCGRMVDKLCGTGADSTKRYKFVHHLPVAVDMTGTAGLREEQEALLEAHTNRNDSRDSSETAMVMDHGAGMLATGGGRLEELFLSSSHAKMYTAINTVLIAPCIVGKSNMFRRSHLDYLTAPSPADPHRRNAGIDYFSDNICEDHLIGDLLWRKQVRGEKEQGERWGKHALVFGDLAFQPVANMSVQAYVARRVRWLRVRKFTVVLATLVEPGTESILCSCYGAWGVTTALAQYLGEQGYAIAEALSTWTAFWGFFCLSIVTWILIDWTVYIMLHSGKTVELDEDTPSFARPPRGVTRRPFRAWFTAWLGREMLAFPIWLWAVYGGVTVIWRDRQFRVGLDMKVREIGGDSLAMKGTSSSRSSSSSSKARRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VUQ0</accession>
    <name>A0A8G1VUQ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LYR motif-containing protein Cup1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_433617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520990.1">
        <property type="nucleotide sequence ID" value="XM_025658428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VUQ0"/>
    <dbReference type="GeneID" id="37161830"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20263">
        <property type="entry name" value="LYRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYR motif-containing protein Cup1-like N-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="338" mass="38622" checksum="2F2BA36F6FA05E4A" modified="2022-01-19" version="1">MSAIHIPPETWRHLLRSLLRECSYLPDPVARVTFHAQILQRFRRYTQKKETDQHRLLLLRKSATHQLSLLRRANEGYTKPLEKVLQQAYGRRGRRRQELIQALVTPADAVDALNAADVQTVAQEAPEMFEDGWRPPSVMVDLLKAQNRNSMITTLNAGYYTKQVEPVVPAENIWGKPLAPSRRRNIRRKWYNQTLHNLFPPLPDSELKVLEGLMSGTIPWAPPKRRKAVGTSSAPESTLDAGFLTEGPQKGDTFENYVDGRPHNITRRFMQRLWKRISCLVPRVNWDTRSGKPAFTWDVLYSGPKLALRLDESTASELFAGIDANGRMIKEQPKEASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRH0</accession>
    <name>A0A8G1QRH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_170365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510898.1">
        <property type="nucleotide sequence ID" value="XM_025654284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRH0"/>
    <dbReference type="GeneID" id="37157686"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034608981" description="DUF7137 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="4">
        <location>
            <begin position="110"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH52976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="282" mass="29142" checksum="3418EDE4B9414AC5" modified="2022-01-19" version="1">MRSMSRLFVLCLLLVLGTVTSAWPWPPHGELLRRADTTAAESATTGAAATTESASKTEAATKTAAATGSDTTATATGTNTKSATGTGTASGKSSGSSSNSTTSVSINPAAGAGGISMLIPTQGATTYYKIGDYVTLKWNYTSLTISPTAVNVVASCSLNSATYTLTSNMTMSPTGEVVWDTKKYQANATVPLLTASYTLIVWDASKAITETASAGYLSAASSYIFGMYSSQPYTPLNGFVCATCSGAFSELERLGMKFTFGMFAITVLSFTWFAGGFGLFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRX8</accession>
    <name>A0A8G1QRX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_453986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510394.1">
        <property type="nucleotide sequence ID" value="XM_025661173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRX8"/>
    <dbReference type="GeneID" id="37164575"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF424">
        <property type="entry name" value="ACETYL-COA SYNTHETASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="478"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH52472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="588" mass="64710" checksum="54B190CAA5D45AE4" modified="2022-01-19" version="1">MHPPPMPRPHSDRSSHTVSKWNTPIPQCSLPRFVFGSPRRSLSSRKILIDADSPDTRALSLAQYRLLSARVAVGLQKLGVNPKDRVLCVTSNALCYPALLMGTVMAGCIFASGQPALNQAEFHRLISFSQPSVIFASRATLPVALQAARLANHPDNRIFVFDDDILDGCGEPEGPIQHWQTMVASEWEGSRFWYPTVISSQEYNSTIMLLFTSGTTGEPKGVELSHRNYIAAAMGYIRRISSHPAWKYNPRLGGPENVRVLGSLAINHSVGQRSYCAIFPRMGVPLYLMRRNDFRSICEAVERFQITDAIIRSSVLTSMAKNAPICREYDLTSLRRVEACAAPMSQFTKFKLESLGIGYVARAWGLTETGTITGPDPLRPPKSETVGQLNATYEGKVTDSSDYSRTLKTGEVGDIWIRTPGSTRGYWNNPAATEQVMGAGGWISTGDVGYVDDEGNWYIVDRKKDLIKVNGSHVSPVEIESVLLQHPHVCDVGVIGVAVNEDEGPRAYIQTYPKTSVSAEEIHELISEKLPPYKRLSGGLSFIEKIPRNASGKVLRSELRQLAISELGDYLGNYHGTSASSSEDGVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS91</accession>
    <name>A0A8G1QS91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_175449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510559.1">
        <property type="nucleotide sequence ID" value="XM_025654316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QS91"/>
    <dbReference type="GeneID" id="37157718"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="286" mass="31784" checksum="0074BB411CD8A662" modified="2022-01-19" version="1">MVARSYETPIIVSLVFSIIAAIVSLGSVFGSCLIRRPTHNPKAIPFKSLFILLLSQTIHIAFTIYSLLNLGDAPPETAEAMKIIPQICKYLQSILILNVLYRLIHAYQAQNRNDITKTILPSQMHGSTLVSLVIISIPHFITWLLSQLGYDTDYQHSTYGLQLAFDGIVTIASLHISFKIFTIIQKLNNARRFSMNGASSLAVGWFFFFTHSLSLLIGDSKGQGTAMTDNMNYEEIVPFICITGQSIGIVHCCMQVHKLGIYGLFRPSSANDERAHILTGSNEEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT66</accession>
    <name>A0A8G1QT66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H2 subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribonuclease HI subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_406277</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511136.1">
        <property type="nucleotide sequence ID" value="XM_025657329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT66"/>
    <dbReference type="GeneID" id="37160731"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09270">
        <property type="entry name" value="RNase_H2-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="8">
        <location>
            <begin position="43"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="7">
        <location>
            <begin position="127"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH53214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="415" mass="46022" checksum="570D2E3A603A61EC" modified="2022-01-19" version="1" fragment="single">MRTRSSAPSEQPQSPPSTSDHQTTAAASTSAPPAQSTPKKTFILPSTASADARFLTLPNPRSTVPTRYFFDPKLGVYEFTVLSSPPSAPRSTLLVRNPDSSSSTPQPPAHISKKAELLLATPIDILFFLIPILTANTKQNNLFQPLDDIIDSLDEELLPPHLRHVLYDETFRETLHARAAAISDSVEAGDEKMFRFNETKLLQELVAKADRMVSAGLPPSLEERFVRQALATPLMAVKRDDVAATGENKENEGEDKNEEKGTDEKTTTNNEDAKEDLPEGVKVPEGVANLLRIFVALSFMKECYLSKEMSARIDELLAAPESPKDFKPMRDHLDLVAKLRAEALASRSLGDFSRKRSVEDQEAAESRAEKKRRMEEEEKKKKANESRGVRDLKKVNTTGMKKMSDFFGKAAAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTQ1</accession>
    <name>A0A8G1QTQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_432235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510002.1">
        <property type="nucleotide sequence ID" value="XM_025658370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTQ1"/>
    <dbReference type="GeneID" id="37161772"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="496" mass="55500" checksum="00F177E126BE4DAC" modified="2022-01-19" version="1">MCIVEEYTASYPDVRRRRVLQRCLLRRSLGYCYRTQVVSPGERIPERPASQFQYGKPRSTTYRPAMQSLRDLIVDPREPARRRQSPNYPRRMPARRSDPFRVFFPFLRRASDSDDGWKDDEYRPRGRGRSPRPVSMARDVPPIKREPRSVPRRRPLNSKVRVVTPPPEPLYKEEPLRPRPGRSPASPSLSPRDPGIFRRPVIIHQEPKPRPSPMPSSGTSGYRFRNPWHSRSPSPGPSNWRRKEPRPSPSVSPGPAKPQEPQPQPSPPGAPSTNAPAAPVTPPKKKERRPRERSPSVERVPIRKTRSTPTVPVEVHNPPAPDSGPKPVTTSNTTSPGSGPRHVQFSDIVDHLSISGESNAPSSPTGPPRFYRQFASASRRRSPTPGPTPRVREGRSDTNSQRTRYVYASPAASRSYPPGVEVLIVTPRRYQPGGITSPVSREAVDIHEVEPGGSSSWSGRAARTWDGEGGSGNRCEAEDRITFTAERAMEAQNAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTU6</accession>
    <name>A0A8G1QTU6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_506038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510644.1">
        <property type="nucleotide sequence ID" value="XM_025664362.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37167764"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="5">
        <location>
            <begin position="346"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="6">
        <location>
            <begin position="1213"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1213"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1374"/>
            <end position="1522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1565" mass="173003" checksum="D8D49BC9FF8E9A6B" modified="2022-01-19" version="1">MAPPRLLCFGDQTTDSCSRIKDLYAKATQYNRLHDFLTVVDRLVRSQRLGISTTDNPLFDDYDSMDTVAEAYAQRTDYGVVMPTVLLCVAQLGGLILHLEEDPTLLWGQTSKLHIVGLCTGLFPAALAATVPSPAELLPLSLLMVMLSLRLAIQVDRRSRYIEASTQSWAVSVKRASAGELERVIASFNEEQLPEHKRAYISAELDTSVTISGPPSTLSLLMRHPSISNLPKSELPIAAAYHAPHLKRPSLEDILGPLKVPDLRVRRNVTVVSPNSGMPYATASLRGLLHFMMADLLQNKVSWNRMMRGLPPGLRTPNATMAVTPSDRLGSLVDEAFLGEYFDADYNTVAIVGMSCRLPGVGSPDDLWKILENGQSIYKGTPAKYLDAHTSVDRFGSVTNSSQSVQSRFIDQPGLFDAGLFNVAPDDVKDMHPIKRLLLLAMYEALESAGYTPHSRDSQRVGTFIGQATDQPRYLRDTVGAGRLNQYFKWDGPSYTIETASSPSTAPMEMAYHALRRSECDIAVVVGTNHLSDPTCNSTEEGHFLSEGVGVVILKRLPDALKANDRVRGVITAVVSNNTGNPCNKPPQKRLLKDVLRRARLGPGDLDYIEGDGCDEEQNMAQVESIVDLMSLAPEGNEPLRVGSVKPTVGHLGAASGILSVLKSVLMLERELIPPDVGISSASKRQLAKGKVEVPQSAMAFLQSRRGRDTRRILVNHSNAMGDKMALLIENHPCAIPQKRSDQRANYMVAVSGQTVKSLRGNQERLLQYLQAQPEVQLANIAYTTTARRLHHVYRRAYSVGHVRQLKEILQKELADPLPVDLVGIQPSRVFVFTGQEGQYPGMGRQLFRTCPTFKQRLLECNNICTQLGYGPFVDIIEREDLDLGDVTPVQSQLAVISLELALAHAWRAWGTTPDMVLGHSLGEYAALCVAGVLSLYDTLYLVGARAQLIQRDCTSDAHGMLTIRSDPETIRDTLLQYEEFAGCTISCLNGPSSTVVSGEHDQLCLLKDHLAGISTRLLPVPFGFHSPQMDSTLDEYRQLCSSIQFNAPRIPVISTLTGCAVERAGIFEPDYLARQTREPVKFQDALRTCEMKLTEKGKGLWLEIGPAPVCTEIAQSQQSVPGQHMLFSLSPKRDDWEVISQALTQLYTIGSDINWGAFHSDYVDNLQLLDLPKYAFDLKDFGIPYQKDSVRMTGGRPNGPSREIPFSTSTLHKIEKEVHGDKRSAVTFLSDLSLPALLSALKGYSMFNQCVFPSSVYTDMALTAASYTCKVMEAVSEVPPMSVSNMEIIQPLVVRQNQPNPVLKLRAERSKGSNCVEVVCSSQAPSSPEEQRLARCTVYFDSSDSTKQNLRDRSQHTQAKCDTLQRAARTGSAHHLRNSMIYRLFAQPIVYGPRYRCIREITMHEEMREATAIIKFPRPATGETFTVSPYWMDSFIQLGSFALNGHDKAPENTSYICTGWWKLWAPADLSPDREYTSYVHMQETEPESGLHIGEVYLLSDGQIVGGCTGLRFQQLPRPELCELLTTGTSRSVAKAPAPSTEPETPSYTKPQIIKGKAVRFLRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVF8</accession>
    <name>A0A8G1QVF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_403793</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512321.1">
        <property type="nucleotide sequence ID" value="XM_025657244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVF8"/>
    <dbReference type="GeneID" id="37160646"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF7">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="75"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="236"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH54399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="563" mass="62278" checksum="00C9362B71E43DFF" modified="2022-01-19" version="1">MHSEMPSWQKAAQAKRQAILNAIPQKWRIQYDTLPVDVTGEFIQGYLTPREIEITESDAIAITSQTTSGSWSAVEVTEAFCHRAAIAHQLVNCLHEVFFEDAIRVAKELDEHLAATGTPKGPLHGLPVSLKDQFHVKGVDTTMGYVGWIGTFQGKKDDPRHRVAESELVRELRNLGAVLFCKTSVPVTLMSGETTNHIIGYTWNPKNRHLSSGGSSGGEGALIGLRGSPAGFGTDIGGSVRIPASFNGIFGLRPSAGRIPYEGAANSIDGQNTILSVIGPLATSIGGLRLLFKAILSQEPWQHDPLSLPLPWRDDVEDQTKKLISKKDSTSSQLTFGIMRHDGRVEPQPPVKVAMDFMERILKDSGHQVIEWDPDLCREGQKIASEIYDMDGGEDLLSHIALSGEEQIPQCSVEPVKPFNAREVAELNVRKRDYQKKYMDYWNSTAKLTTTGRPVDAVICPTAPHAAVIPGKYRHTGYTTFINTLDYTSLVVPICCADKCLSSMAERSEYLSELDRKIYEDYDPEIYHGAPIGLQLFGRRLEEEKIITIAEYLSEKVKVYTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVI9</accession>
    <name>A0A8G1QVI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_427471</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512366.1">
        <property type="nucleotide sequence ID" value="XM_025658157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVI9"/>
    <dbReference type="GeneID" id="37161559"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000010">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000015">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF91">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="247"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH54444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="671" mass="75335" checksum="0995FCE96A7F108C" modified="2022-01-19" version="1">MLPHPLAILSEEETNIARNVIIAQHPNTVIDFREIYLSEPPKAQLLEFLALEHSGRLSPTSPRPPRLALCQYDVIGNDRIPSFEESVVDVGTRQRVQHRVVGKEHHASLTLSEFDTLVERCFASPLFQKALADFDLPEGFEVVIEPWPYGGLDYVEEKRRYFQGLCFATDTRKNNPDANFYSYPLPLIPVMDALTQEIIRVDRPATGGKGEGLTEQTFKRDIIGHCKDSDYVPELLPGGTRKDLKPLNVVQPEGPSFRITEEFLVEWQKWRFRVAFNPREGATIHDVWYDGRSVLYRLSVSEMTVPYADPRPPFHRKQAFDFGDGGGGNMANNLSIGCDCLGVIKYFDAVMTGADGTAKKMPNAICLHEQDNGIGWKHSNWRTGRAVVTRHRELVVQFIITLANYEYIFAYKFDQSGGITVESRATGILNVVNIDAGKVSEYGNVVSGGVLAQNHQHIFCVRIDPAIDGPNNSVQVEESHPVPMNAVTNPNGNFYKVNTETMERAGFFDAAPELNRTVKMVNPHKKNPISQKPVGYKFIPLATQRLLADPNSIQARRAQFAQHHVWVTKYRDGELYAGGRYTLQSQEEIEGVSDAVKRGDSVVDTDVVVWSTFGITHNPRVEDWPVMPVEIFQLMIRPADFFTANPSLDVPSDKNVSSRVVGNDCCRNAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVX7</accession>
    <name>A0A8G1QVX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_83950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513298.1">
        <property type="nucleotide sequence ID" value="XM_025665721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVX7"/>
    <dbReference type="GeneID" id="37169123"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05578">
        <property type="entry name" value="STKc_Yank1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000354">
        <property type="entry name" value="AGC/YANK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000469">
        <property type="entry name" value="Serine/threonine-protein kinase 32B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="384"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="384"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH55376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="541" mass="60597" checksum="C9F94AC73FA1D0F5" modified="2022-01-19" version="1">MGNSQGKQVAATDELNLNQFRLLRVVGKGAFGKVRIVEKKDTGLTFALKYIRKEEVVRSESVRNIIRERRMLEHLNHAFLCNLRYSFQDIEYIYIVVDLMNGGDLRFHISRKCFTEEAVRFWIAELGCALRYIHSQGIIHRDVKPDNILLDSEGHVHLADFNVASDFRPGKPLTSKSGTLAYLAPEVYEGGGYYCEVDWWSLGVTFYECIYNKRPFEGRSQDVLSENIKKAQPKYYVTNPAVSVPCLRAMSAFMERDRSKRIGAISFESFTSHMFFADLDFVALEAKEIPPVFRPSSDKTNFDATYDLEELLLEEAPLEARARRQKPRAELREDATAKEIREDELHRLIETMFEPFDYTKVNYVGNAADAIAASTNPEECLPIHQTQSSTHSRQVSQPDLSRNSPPLRNDGSVSHLTQPDTPSPLSETPTSQASLPPPPPPPAPPFHRPLPPTAVRPRGATRKQSKGGGVQMVLEEAGSWSELADHSSTLPAEGYDTGSVKGKGSNSGMLAFLSRKKGRDRSPKPQEPGVLGKEGARQIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QW38</accession>
    <name>A0A8G1QW38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_451254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513388.1">
        <property type="nucleotide sequence ID" value="XM_025660549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QW38"/>
    <dbReference type="GeneID" id="37163951"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034111865" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="55" mass="5839" checksum="B005A9E91B734DF8" modified="2022-01-19" version="1">MPFSLSAGLLLLLLALVLFLLFHFITSGHSAGSCRRPLHSSLRSGDVSAISCVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QW99</accession>
    <name>A0A8G1QW99_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_522716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512735.1">
        <property type="nucleotide sequence ID" value="XM_025665287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QW99"/>
    <dbReference type="GeneID" id="37168689"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034462040" evidence="1">
        <location>
            <begin position="21"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="98" mass="10488" checksum="3A5FEBDBE90A9938" modified="2022-01-19" version="1">MKLLPTLVAGALALTTSVQAANCNAGLNYCANILKSIDSKYINLMTAAIAEKYTEFNSAIAHPMYYLWHCNADGSVSIVEKCTWGCEDAGPGNSDYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWA2</accession>
    <name>A0A8G1QWA2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ and TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_91223</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512970.1">
        <property type="nucleotide sequence ID" value="XM_025665782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWA2"/>
    <dbReference type="GeneID" id="37169184"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052758">
        <property type="entry name" value="SRC_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="432"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="478"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="516"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="604"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH55048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="743" mass="80701" checksum="24012B279E7D0BBC" modified="2022-01-19" version="1">MGLPHLFSRHKSSSSKSSSSKSKSTPTTTASAPVPPTPPTRSIPVSSPPPSSSPLPPPPYSSSSYSASSPPPPRPSARVKTDDSFPTRPPPPPHRAKTVHSAPSRHPHPPPTPPLHHPQSFPTPTQRPSIPRKPTRPAHSRSTSTPSKSASVRSKPSSVPRSASSLSAVHHRYSHDPNFHPLNLHPDELRRLSAMAAARDDMRSSMDVDTNDPRLGSPSATNGVNGTHTEKSPTPPPHRSNGNTAEADSFKLAGNKFFKDGNYARAIEEFNKALEISPNSSVYLSNRAAAYMAANQYLAALEDCERARELDPTNTKIMYRLARILTALGRPTEALDVLSRIEPPASATDRAAAEKMLRFVSQAEEALSQDRGVSMVLFCLDQARQLLGQGVKEPRKWTLMTAEAQLKMGNDNSYGKAQDIAISMLRVNSQDPDALMIRARAFYGMGDTDQALKLLKMCLGLDPDMKAAIKLLRTVQKLVRTKEEGNTAFKARDYRRAIDLWGEALTVDPKNKDQNAKILQNRAQAYINLKEYDNAVADCNEALRLDPGYLKAQKMRAKAHGGAGNWEEAVRDYKAVAESNPTEKGIQEEIRKAEFELKKAQRKDYYKILGVSKDAGEQEIKKAYRKMAIQYHPDKNRDGDAGDEKFKEIGEAYETLSDPQKRAAYDNGDDLMDPADMFSHGGFGGMGGMGGMGGMGGMGGMGGMGGTHINIDPSVLFNMMNGGGGGFAHAGGQRGGFPGGFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWK7</accession>
    <name>A0A8G1QWK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_452293</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512253.1">
        <property type="nucleotide sequence ID" value="XM_025660785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWK7"/>
    <dbReference type="GeneID" id="37164187"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF11">
        <property type="entry name" value="O-METHYLTRANSFERASE (AFU_ORTHOLOGUE AFUA_2G17820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="56"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="232"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH54331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="399" mass="44677" checksum="2CCA4118C7C168AD" modified="2022-01-19" version="1">MADIVTTLTSATNAALAQLTPEDEIPEAARYQLLDAIDKLRVAVEPPLLTIRNFCFGHHGLVAIRIAMGMGIFDAFASAKGGEMTADALDEKTKGDKSLLVRIMRVLCANHVFKETGVQKYQPLPLAMIFSSNSPPSEVIKHFHSDMKASVHSLDYFEARGYQNPEDAYDTTFQLAFRTKEHYFEWIQHNPEELHAFNTVMEIGNRSLEGVQWYDYYPWQERLATTDGTDRVLLVDIGGGKGHDISGFKRKFPEIKNQLIVQDLPGVIGDIDEPLIEGVTAVGYDMFHSQPIKGAKAYYMRTVLHDWPDKQALQALSRVHDAMASDSVLLINENVLPEMNAPGFSASMDIIMMELYGSMERTEKQWLGLLDKAQFKVLKVWRSGFQGTGSNALFEAVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWM7</accession>
    <name>A0A8G1QWM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Na+/solute symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_504306</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511457.1">
        <property type="nucleotide sequence ID" value="XM_025664295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWM7"/>
    <dbReference type="GeneID" id="37167697"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000006">
        <property type="entry name" value="Urea active transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF1">
        <property type="entry name" value="ACTIVE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="613"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="659"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH53535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="681" mass="73944" checksum="6E45AB74B04C41E4" modified="2022-01-19" version="1">MSEIQARAAGASVQPPLSQAVGYVIVVVLGLIIAGADKTVMMVITRILKETTGEDNKKTEMFMTANRTVRTGLTASAVISSWLWTTAMLGASFVGYDYGVAGPFWFAAGCSPMIVFFALIGISCKRKIPDAHTSLEVVRIRYGRIAHVVFMTLCLINNIFACANMLLGAAAVISAITGMHIIAATFLLPVGVTVYTFVGGIKATFLTDYFHTAIILVIACYLSIKAFTFEEVGSIGRLYELVQAAAQRHPVSGNQDGTYLTMTSKGAILFGILHICSNFGLVIMDTSYFIKAFSAAPSSVVPGYTIGGIAYFAIPWALGTIMSSLALGLENTSSFPTYPRRMTSTEVSNGLVLPYAAMTIAGKGGAAAVLLITFMAVTSTLSAQVIAVSSILSFDVYREYINKDASDRDIIRASHFGVIFFAAFSAGFSTMLHYVGIDLGWTLYMLGVVTCPGIFPMAFTILWRRQNRAAAILSPILGMATGIGVWLGTAQHFYGAVSVSSTGQILPCVYGTVASAFSPIVYSVVITLVKPQRYDWAEFRKEKLGLERLDSDSDITVNGQGSEVQHTQSSFNPQELKRWGRIAAYWSIATFLGHWVLWPLPMYGSKYVFGKRFFTAWVVVGIIWLWITMLVAIFYPLIDGGVQQMMQISRGLRERKNAVTSSSVPSVTNDSPEVFRVNEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX52</accession>
    <name>A0A8G1QX52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_403204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512538.1">
        <property type="nucleotide sequence ID" value="XM_025657215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX52"/>
    <dbReference type="GeneID" id="37160617"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH54616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="427" mass="47855" checksum="A1ECCF27A73543DE" modified="2022-01-19" version="1">MKILIVGAGLGGLAAAYCFAKDGHHVFERREKLSPKGSGLLIRPGASRILQSWGLGDAIEQVADTCLPILIRDLKTGKDKIRTLPASFTKYPDWGIHRPILQDILYQHAVHAGAEIIFRSSVEDFSDEPGVSPSLQLKGGKTIAGDLILIADGIQSRLRTKVLFDVSAGWSVNPQVSDSVYYGVTVPQKELQSDSDARLLLQEFETCVWAGDERFVIGRKPRKMEFWSGLFGLKHDDDHASMWSEDGDIAFVRQRFEGICPPLSAVLKLATKCDRWKIAQIPNLPRWTSRTGRTILLGDSAHAMEPNAAQGLSQIIEDIGVLHILLLSLPYMSVSVISRFWEDIRKPRVERIKSFAAWNTQRFLGHKDHAASHQKYADADWESIKDIEPDPAADFTSPAFFKWAHDYDIVEQTRKYLEKVNTPISRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY20</accession>
    <name>A0A8G1QY20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_404550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512177.1">
        <property type="nucleotide sequence ID" value="XM_025657275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QY20"/>
    <dbReference type="GeneID" id="37160677"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000003">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="10">
        <location>
            <begin position="109"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH54255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="223" mass="24800" checksum="DFD6BFEFDB028565" modified="2022-01-19" version="1">MADTTPPSDTQKHLFIHQQQQQPATPSSSTQQQAPAPATTKDDSVPAGMTKLPNGVILDKDGKPCRLCTSAASWRALTKQAKSTPTTTSSTSSTTIPKALTTTPGYTDCPPDSEALGRSTWTFLHSLTASYPAQASSEQQSEMRQFLGIFSKLYPCWVCAEDFRTWMAEPSGENQPRLGGRKEFGDWMCRAHNEVNRKLGKSEFDCRFWEERWRKGWGDGRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY93</accession>
    <name>A0A8G1QY93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">60S ribosomal protein L7A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_460935</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513755.1">
        <property type="nucleotide sequence ID" value="XM_025661748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QY93"/>
    <dbReference type="GeneID" id="37165150"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000001">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="11">
        <location>
            <begin position="304"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="176"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH55833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="444" mass="49282" checksum="65E8846F21247E54" modified="2022-01-19" version="1">MINAVLVFNNNGQPRLTKFYTQIDTQTKQSLIAQIYNLVSQRPASVCNFLPLPPLLSRGASSGAENGPSDAPTQITYRNYATLSFIMISTSTESPLALIDLIQVFVEALDRMFENVCELDLIFGYETMHAVLSEMIVGGVVVETNIDKIVSASAKLIELLLFFFFLTVNPAPNAAADPVDKMPAQKSGKKTAPLPYPQGKAGAKKAPKNPLIEKRPRNFGIGQDIQPKRNLGRFVKWPEYVRLQRQKKILNLRLKVPPSIAQFQNTLDRNTAAQTFKFLNKYRPETKVEKKERLHAEATAVAEGKKKEDVSKKPYNVKYGLNHVVGLVENKKASLVLIAHDVDPIELVVFLPALCRKMGVPYAIVKGKARLGTVVHKKTSAVLALTEVRSEDKAEFAKLLSAVKEGYSDKYEESRRHWGGGIMGAKAVARQEKKRKAVEGAIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYB7</accession>
    <name>A0A8G1QYB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_479292</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513739.1">
        <property type="nucleotide sequence ID" value="XM_025662943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYB7"/>
    <dbReference type="GeneID" id="37166345"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="10">
        <location>
            <begin position="246"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH55817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="561" mass="63691" checksum="42908CB4C7FD2A19" modified="2022-01-19" version="1">MHSLHNMEPQSNEEWQIEEGIPQVEDPFIQQYLRGRCSLILEEQKQRHDSNLTKALPPTAARACNIVARIRDRELHQLSSLSGLDDARFPEAKSLDWDRVQQTKLWRIIKAMPKGSLLHAPLHAVINADFLIDVAFTTPGLCVFATQPLLSEDDLEEKLFAFQYSLAASKDLEDRPTVWSSAYEPSSPIPLKKAASSFPYGGENGFRDWLRSRCIPQAGRANYHSRAMPIVSSLLSYEPILRACLRHVFARLWSDGIKYVEFRTTFTFPYRKEGKDIPEEGHSDWCHVFQEELARYQGTQEGQGFYGARIIWACPRSLSKRDIVENMKDCILAKYDYPDTICGFDMIVDKDDRHSLTDLVPILFWFRKECSAEGLDISFCFHAGESLRNGGDQGLFDAILLGARRICQGLSLSQHPLLIELIKEKKILIECSPLSDEILGLTDSIQTHPLPVLLARGVPVTLGINAPGLLGEPNDLTRQFWQAVQGIDSMGLTGLAMMVENSIRWSCYQDQPSAEWQSDLREGILGEGTKASRLQEWYADFERFCQWVTEEFAEAEGEEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYY8</accession>
    <name>A0A8G1QYY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nonsense-mediated mRNA decay protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_378669</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512657.1">
        <property type="nucleotide sequence ID" value="XM_025656308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYY8"/>
    <dbReference type="GeneID" id="37159710"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000244">
        <property type="entry name" value="Nonsense-mediated mRNA decay protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="897"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="905"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH54735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1045" mass="118743" checksum="8948791311B658C2" modified="2022-01-19" version="1">MDVAALRDRIQSTLDPNADNRRQAELDLKYAEMQPGFINALLDILQGEQNNAVQLSAGVYLKNRINRGWSPVEESPLRTPIPEEEKPGFRERLIPALASTPPNVRAQLVPLLQKILQHDFPEQWPGFLDITLQLLGMNDANSVYAGLQCLLAICRVYRFKAGEKREEFDKIVEHSFPQLLSIGLKLVDEESLEAAEMLRIVVKSYKHAIYFELSPHLQTQQATVDWCTLFLRIIAKEPPASAMNESKEERELNHWWKCKKWSYANLNRLFIRYGNPTTMSKSSTPDYTQYGKAFITTFAPEILKGYLQEIDKWVSKGQWLSNPALAYTMIFLEECVKPKAMWEHLKPHMDNLIAHFIFPILCQSDEDIELFETDPSEYLHRKLNFYEEVSAPDVAATNFLVALTKNRKKQTFSILTFVNSVVSKYESAPDDQKLPREKEGALRMIGSLASVILGKKSPIADQVEYFFVRHVFPEFRSPHGFLRARACDTLEKFEALDFQDPNNLMIIYRNILESMTDSELPVRVEAALALQPLIRHDIIRTSMQQNIPQIMQQLLKLANEVDVDALANVMEDFVEVFSAELTPFAVALSEQLRDTYMRIVGELLERNAAKGDEDAYGDFLDDKSITALGVLQTIGTLILTLESTPDVLLHLETILMPVISITLENKLYDLYNEVFEIIDSCTFASKSISPTMWQAFELIHKTFKAGAELYLEDMLPALDNYVAYGSQTMVQTPAYLAAVVSMVEDIFQDEKVGGVDRICGCKLAETLMLNLRGGIDQYIPVFIELAMRVIDAGEARTKSYRIHLMEMVINAIYYNPVLSLQVLEAKGWTNKFFSTWFSNIDNFRRVHDKKLSIAAISSLLTLNANDVPASVQQGWPRLLQGVTRLFQTLPAAIKHREDATKESDFTFDEEEDEGDEENDWDGEVEWTEQDEAEALLEGDVPDDSAAYLDFLNKEAQKFGSFADEDEDDLDEESLLETPLDKVEPYGMFKHVLMSLQQEQPQLYENLAKILSQEEQQVLQSVFHEAEAKALAAANAEAAGVQTNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZI9</accession>
    <name>A0A8G1QZI9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BYS1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_452557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512112.1">
        <property type="nucleotide sequence ID" value="XM_025660847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZI9"/>
    <dbReference type="GeneID" id="37164249"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF4">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034787820" evidence="1">
        <location>
            <begin position="24"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="160" mass="16604" checksum="9F37A4A472EB02E8" modified="2022-01-19" version="1">MHLTTKSLLSFLLPLLPLTAATGSAIVQNNCTSPIYLWSVGGSVSSMQTIDPGSSYSEAFYYDSTSGGVALKITTTENGLYSGAPQTDYAYTLDTSSGNVFYDISDVYGDPFSGSVVSLVSSDASCQSVCWAGGVPPAGSVVRSCQDEADEILTVCADSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZQ3</accession>
    <name>A0A8G1QZQ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 15">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11 15">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO85DRAFT_451353</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 22 23">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 15">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11 15"/>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513496.1">
        <property type="nucleotide sequence ID" value="XM_025660575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZQ3"/>
    <dbReference type="GeneID" id="37163977"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14291">
        <property type="entry name" value="UBA1_NUB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14385">
        <property type="entry name" value="UBA1_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000086">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000103">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000587">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000144">
        <property type="entry name" value="Ubiquitinyl hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF664">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11 15" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11 15" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="19">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="19">
        <location>
            <begin position="153"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="18">
        <location>
            <begin position="304"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="585"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="647"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="734"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RAH55574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="780" mass="87006" checksum="77135B1B69AE72B4" modified="2022-01-19" version="1">MMASCSHVASEGLREPATSQVVYREDCTQCFDSIDDEHGLNVCLTCFNGGCAGDRNHAFLHYERCSHPLALNIRRSRKKVQRDEPPQKISKLAIAAETDEDRYDTKTRVVCYPCRQSDLDASSGRLPAVIDGVMKAMTFSKREEVKAWEQEFIPCEHTINLIQGASRQIESKELVQCSMCNLKENLWLCLECGNLGCGRSQFGGVGGNSHALAHSDKESHAVAVKLGSITADGSADVYCYRCNEERTDPNLATHLANWGINLASREKTEKSLMEMQVEHNMRWEFSMTSEDGHELTPVFGPGLTGLTNLGNSCYLSSVVQCLFALPEFQKRYYHPNSEPPHTQRPAEDLETQLRKLADGILSGRYSRPDSEVRSSPDSAEVPHQKGLAPAMFKHLVGRNHEEFSTMRQQDAFEFMLHLFKQISLSKHPEGLDNPITSFGFSVQQRLQCLRCKKVRYRADAQDNISIPVPARRLPGADASDSINEYESVTLAECLDVFTAEEVVEFSCPSCGSTEGFSKKTSFKTLPQKLVINARRFELINWVPTKLNIPVEVDEKPIEFGTYLSSGPDPNEELLPEIQEPENVFKPNEIAIEQLVAMGFPNPRCEKALYMTGNSDVEAAMNWLFAHMEDPDIDEPLDKMVTSTSGSQQDPAKVAQLTEMGINSSHARRALAATDGDLNRAIDWVFTHPEDSMDLSSDSDIPEPSDKCQGSDATPAKYQLQSIVCHKGSSVHAGHYVAIVRKAVPGSNGTSWVMFNDEKVVQVDDIQEMKKFAYIYVFSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R047</accession>
    <name>A0A8G1R047_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphopentothenoylcysteine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_83200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513257.1">
        <property type="nucleotide sequence ID" value="XM_025665714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R047"/>
    <dbReference type="GeneID" id="37169116"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF21">
        <property type="entry name" value="FLAVOPROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="2">
        <location>
            <begin position="127"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="634" mass="70550" checksum="8197D247EA7EE4D1" modified="2022-01-19" version="1">MAVGFGASFPSTSTGVATVVSKGVWSSEMEVTTEMGGKLTENTTTTPMQIDNQIQEAPGSSPPRRKRLLLSTESAFVDNILPSLVQNPDIEIRLITDEPSALLSGASKVPHYMDTVDSQTFEKKTGARKWLKAKAAELCEWADMLLVAPIDAGALGSMLYGLTNTLTLALLRGWISSKPVVLIPGMTVSEWHHPLSKRQLREVAEFWPWISVVSPVLWESVSPEELVQLPWEGLKELHEVLERTLGLSFSQVSTKPGQLTDSTYPTGISEQMPGDAASTISRHLLHRSNKTENGPRSLPMELWLNIFEDQLHDWEIAKAVGIPTNLPVPKEWQNHLLKMSTPASLEYTILRGSFAAIKKRIDSLPRWKPLSDLVCHLIFKFSRTDILSYLTENHLDLLWTTSRLTNLPYRASAIYGNPNILTWWRDAPALPNKEYIADAMDGASRAGFVNVLEWWRTSGLELRYTERALEAASAEGRVAVLAWWKAASANAPPSNPIPLKVGKSVLLAAQSGRTASLAWWDASGIPYTHGESVARIASTHGHVHVLDFWYRLKGAKMIFDSQVLVGPTKNGHDNVLEWWRRSGLRVEFKTCDIEEALEDADPVSGAEERVRKWWARNGLNLGVGTSEWMKTKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0H4</accession>
    <name>A0A8G1R0H4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Plasma membrane channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_400110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513931.1">
        <property type="nucleotide sequence ID" value="XM_025657117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0H4"/>
    <dbReference type="GeneID" id="37160519"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="8">
        <location>
            <begin position="16"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="170"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="661"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="682"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH56009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="737" mass="85097" checksum="702158565B732059" modified="2022-01-19" version="1">MASTLPRDPVHSNHYVDYVIRYNFGGETDAAHATEQLDRLLRKLFEVGLQTEVRQGDESSLLIFVRASRKKSLKRAIYQSRIRDWLYGVRNTEPESESSAEAQSESERLRVIYHMITVPKEAGGAGITPKHGEWKCVDAIFPLHDEAMNKQCMKDWSQKTFLSADDLDQIRNTFGENVGFYFAFLQSYFRFLMFPAVFGFSCWLLLGSFSIIYAVVNSLWCIIFIEYWKRQEEDLSCRWQTKGVSVVRPKRREFKPEREVQDESTGEVRGVFPATRRMYRQLLIVPFALLSAVALGVIIATCFAIEIFISEVYNGPLKTYLVFIPTILLSALIPTMSSVLVSIATKLNDYENYETQPAYDVALTQKVFIINFITSYLPIILTAFVYVPFASRIVPYLDVFHLTVRPFVSKEDASSRRTEFSIDPDRLRKQVIYFTVTAQAVNFAMETIVPMLKQRLSREYKQYNRRKQGKIETEDGAEAKKEALFDDHPDETKFLTRVRNEADLEDYDVTEDLREMCIQFGYLALFSPVWPLVPVSFLVNNWVELRSDFFKICMECKRPWPQRADTIGPWLESLGFLSWVGSITSSALLYMFSNGHEGPNGEPTGIRGWALLLTIFFSEHIYLMVRYAIRAAMAKLEPPNAKKERTERYLMRKRYLESTIAARSSDDEGDEQGPDQSMEVPDITRKSLEEDAREWSTHDIDPAERFWMRQKGWKESAHVGATIIKTLATEPTVKKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0J4</accession>
    <name>A0A8G1R0J4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_450344</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514864.1">
        <property type="nucleotide sequence ID" value="XM_025660350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0J4"/>
    <dbReference type="GeneID" id="37163752"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.40:FF:000003">
        <property type="entry name" value="Serine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="189"/>
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            <begin position="1"/>
            <end position="25"/>
        </location>
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        <location>
            <begin position="438"/>
            <end position="474"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="100"/>
        </location>
    </feature>
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        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
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        <location>
            <begin position="272"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
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            <position position="272"/>
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        <ligand>
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            <begin position="288"/>
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        <location>
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        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
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        <location>
            <position position="397"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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            <dbReference type="PROSITE" id="PS50862"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="474" mass="54011" checksum="1C73395FE258F448" modified="2022-01-19" version="1">MLDLADFISDRGGDPNKIKESQRKRYAPESVVDEVLSLYEEARRARYEVMQINSQLNALQKEIGKRKKNKEDANDLMEQKADLERRKKDAEELAIQKEKQRDGKIRTIGNLVHDSVPVSNNEDDNAVIRTWAPDNVKVEKRNCLSHHEVLTRLDGFDSERGVKVVGHRGYCLTGYGLFLNLALINYGLEFLWGKGYKPNQPPQFMLKDMMAKTAQLEQFDEELYKVTESEDKSTDKYLIATSEQPLSALHDGEWLQDKDLPIKYAGYSTCYRKEAGAHGKDAWGIFRVHQFEKIEQFVLTKPEDSWQAFDEMMATSEEFYRSLGLPYQVVAIVSGALNNAASKKYDLEAWFPFQGEYKELVSCSNCTDYQSRALEIRYGTKKATDVKKSYVHALNATLCATERTLCCVLENYQTDDGIIVPEPLRKYIPGAPEFIPYSKELPKDSTSQKNKAKQTTKAVSGADETAKKLEGLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1P5</accession>
    <name>A0A8G1R1P5_9EURO</name>
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        <recommendedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">BO85DRAFT_449555</name>
    </gene>
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        <name type="scientific">Aspergillus piperis CBS 112811</name>
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        <lineage>
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            <taxon>Eurotiales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="term" value="F:pyridoxal phosphate binding"/>
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    </dbReference>
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        <property type="entry name" value="MoCF_Sase_C"/>
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    </dbReference>
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        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
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    <feature type="chain" id="PRO_5034142197" description="MOSC domain-containing protein" evidence="1">
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            <begin position="28"/>
            <end position="352"/>
        </location>
    </feature>
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            <end position="340"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="352" mass="39930" checksum="B32D700F7A23E89E" modified="2022-01-19" version="1">METSTLLLLTTLTILLLPFLLSPKATHILKHNLNLLRHHHPKPTTIHSLYIYPIKSCRGIRLPQTTLHKHGLSLDRRWMFIDAKTNQFLTIRQDSRMTLITTALSADSSHLLISIPSFSKDKEISLPTNPTPDWLAQHTTLEHVTIWDTVTDAYAYGPDVNAFFSEFLGREVKLVYKGPERRILRGNGAPEILGREQDTYFPDVHPVLIASVASIEELNARLVKGGNEAITIERFRPNIVVTGDVPWEEDSWKVVRIVGNDKDGKRGDGAVELDVVARCARCQVPNVDPDTAEKHRRQPWDTLMKYRRVDEGIKFKPCFGMLSAPRQEGRVEVGMGFEVVEVTDGHRYIKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1W9</accession>
    <name>A0A8G1R1W9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeobox transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_292877</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025655284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1W9"/>
    <dbReference type="GeneID" id="37158686"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24818">
        <property type="entry name" value="PH_TRF2_HOY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="60"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="62"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="572"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH58048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="604" mass="65419" checksum="24F7A3E3602B95BF" modified="2022-01-19" version="1">MSSTDTPDPSTTSNSSSNPASTMTSSSSTTSSPSPAMSNSTTAASASARRPQRKSTLTQQQKNNKRQRATQDQLVTLELEFNKNPTPTAATRERIAQEINMTERSVQIWFQNRRAKIKMLAKKSIETGEGCDSIPESMRQYLAMQFDPTKPGARDPFGRTGGYGTGGVYPHESAPSGKVVIHHFTCRSLTIGSWRRIGQNAMDLVVFYSPEKACMTYYINNDSAGYKIEYPFAYIKNITLESGDQTPQANGAPPRPGGLVVELNRPPLFYMDSSNSGGFYQCGDFTEDQQASQILVHHLGGHPKVLSVQLAKLVSLESFQNRLAYNNFAMNPPMSPPFIQRPASQPNQFAPAFMNVFPESHAHLNIPAMRGHKRQRSRSVPVAVDFSAMQAPLAHYNMPQTPAQFNHADTGIFAPVPQSTHPLAVNLRIDTSASYGFDPRTHPMSATTTASPSDFASPGLFSTGAGGDSTPVATNMGTPFNLPFVSPAVDSTVASQATYSNVSHADPMIANHSPPLSNISHAPQDMYGLGNEHQPNYTDDGMSMNGIYPKHNMNFAVPASMGLETNTYDLPMQPMSGHTSPGVHGDFQSLSLENVDPNGMAPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2C5</accession>
    <name>A0A8G1R2C5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isoamyl alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_421002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515298.1">
        <property type="nucleotide sequence ID" value="XM_025657913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2C5"/>
    <dbReference type="GeneID" id="37161315"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034499695" evidence="3">
        <location>
            <begin position="21"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="112"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH57376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="570" mass="61224" checksum="FD76797ED0252ABF" modified="2022-01-19" version="1">MKASWSFAATVAALASKAVASSDCHCLPGDSCWPSTSSWDSLNSTVGGRLVATVPIGTPCHDPNYNGAECTNLQDNWYYPQTHLVSSSSVMQPYFANQSCDPFQPESRPCLLGNYVSYAVNVSTTDDVVAAVNFAKENNIRLVIRNTGHDYLGRSTGAGALAIWTHYLNDVEITEWSDSTYEGSAVKLGSGVTGYNVLDATHGKGLVVVGGECPTVGLAGGYTMGGGHSALSTAFGLGADQTLSFEVVTASGEVITASRTNNTDLYWALSGGGAGNFGVVTSLTVKAHPDATVSGAALEFTVANITSDLFFEAVEHFHTLLPAMVDAGTTVIYEMTNEIFLINPLTAYNKTTAEVKTILSPFLSALTDLGIAYTVAYTQYSSYYEHYEKYMGPLPYGNLEVGQYNYGGRLLPRDTLTSNTADLVSVLRNITNDGLIAVGVGLNVTNSNDTANAVFQPWRNAAVTMQFGSAWNETAPWSEMVADQLRIANDYMPQFEAVTPGSGSYENEGSFRQQNWQKEFFGANYAQLCEVKEKYDPDHVFYVTKGAGSEYWSVAESGRMCKTEQACAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2I0</accession>
    <name>A0A8G1R2I0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="2 8">3.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_450625</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate</text>
            <dbReference type="Rhea" id="RHEA:22936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="3.5.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="11">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="2 8"/>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514517.1">
        <property type="nucleotide sequence ID" value="XM_025660421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2I0"/>
    <dbReference type="GeneID" id="37163823"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000065">
        <property type="entry name" value="N-acetylglucosamine-6-phosphate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="12">
        <location>
            <begin position="64"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="338"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH56595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="424" mass="45581" checksum="3566EAE8A1D77161" modified="2022-01-19" version="1">MPGKTSTSLPRITKFTNCRIVKGLDLVEQDVWIDSISGKILKDQEAFYGLHLSPDEVIDLGGRILAPGLIDVQLNGAQGFDFSVPQASKELYDEGLRAVNKGLARTGVTSYLPTVVSSTPEVYWQVLPSLGASGKSHRAEDGAESLGAHVEGPFISPGRNGVHKTEVLRAATCFEDVIACYGKDNLTGPFKSVRMITAAPEVGDMLPNIPSLTSEDIIYSIGHSDATYEQALTATQQGATMITHLFNAMRPFYHRNPGIFGLLGQNECPRPFYGVIADGIHLHPTSIRIAYNAHPKGLILVTDAMKLCGLPDGIYDWTNGERIIKNGARLTLEGSDKIAGSSATLIECVNNFRRWSGASTAEALNAASATPARLLGLQGVKGSLESGADADLLVLDDEEDPFSGPTLTVRQVWKRGVKIYDTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3G6</accession>
    <name>A0A8G1R3G6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfite reductase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_448574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516485.1">
        <property type="nucleotide sequence ID" value="XM_025659970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3G6"/>
    <dbReference type="GeneID" id="37163372"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="317" mass="34943" checksum="17992A1A4776627D" modified="2022-01-19" version="1">MDPTDDPVIASYDICLTDSEISRYVLQYLDRPTGSAYDDRHGQKPTSFRLKPKTGLVEVDVPINTRVNYDVSKGLRYGDALKKSKSAREGGAFGMAGGFSSGGAGGAPAKVKMEDAADAKSETASLMRVQTLGGRIKSPEDGDPVYMLAAFRGDKLHLSPVSAVVQLHPQLHHLDALDEMPTKGKGKARKEGEEDRPGESEARAIDVKIKAAEDGEAAQVAGNLDLLKKMQDEKWKDYEWVDAETEESWQLYENYMMHQDVDSLPQLQSAIDSESYLDTMSAPRIDPARPEMTGWAMKQNRMKQREEQQSAEGITEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3M2</accession>
    <name>A0A8G1R3M2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="10">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_449153</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515973.1">
        <property type="nucleotide sequence ID" value="XM_025660099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3M2"/>
    <dbReference type="GeneID" id="37163501"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="10"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH58051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="116" mass="12839" checksum="7163C5EBDBCDB07D" modified="2022-01-19" version="1">MGKLTSTIGIPIKLLNEAQGHVVTLEITSGVVYRGKLLEAEDNMNVQLKDITVTARDGRVSHLDQVYIRGSHVKFFIVPDMLRNAPMFRSRGQRGRGVGLARGKATVQRARGQRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R498</accession>
    <name>A0A8G1R498_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF500 and SH3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_301474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515387.1">
        <property type="nucleotide sequence ID" value="XM_025655349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R498"/>
    <dbReference type="GeneID" id="37158751"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11842">
        <property type="entry name" value="SH3_Ysc84p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="352"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH57465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="411" mass="43889" checksum="DA9D5CF76622E07D" modified="2022-01-19" version="1">MPLGIHNPLPSSLGSECRKAGKILASFVDPRQAFGPDKVIPPEILAGAKGLAVLTVLKAGFLGSARFGSGVVVARLADGTWSAPSAIATAGAGFGGQIGFELTDFVFILNDAAAVRTFSQVGTLTLGGNVSIAAGPVGRNAEAAGAASTKGVAAVFSYSKTKGLFAGVSLEGSMLVERKDANEKMYNSRVSARQLLSGTIRPPPGADPLLTVLNSRAFYGNARNGSDMYNDIPVYDDSHDDVVWEGRRGEAYGEGTRRDRTGFSGSGSDDFRDRPRRANTWADDIYDRPAGGLSRSSTTRYSGRNDTYDSFNRSRSNTTPIDEDYVYSDRKPSRPTAPKPVFGQRTGAAPALRQDQAVALYTFDADQEGDLGFKKGDIITILKRTDKKEDWWTGRIGSRVGIFPSNYVETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4T0</accession>
    <name>A0A8G1R4T0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polyamine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_282835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515672.1">
        <property type="nucleotide sequence ID" value="XM_025655213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4T0"/>
    <dbReference type="GeneID" id="37158615"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF138">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="110"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH57750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="563" mass="61651" checksum="5165C70D02ECC603" modified="2022-01-19" version="1">MDRLHDADRAGDDDSSIADGISLSRRRYSRGGPPGDDSIELERINTYRLQQQLTVGSRGSRIPQDQWLPIGAGKPYPPPLPDSEAYVVEFEGADDPMHPHNWPMKKRVMLGSLLTSCALVTAYGSAVFATAASGAQKEFGFGEEVAALGTTLYVLGFSAGPTVWAPSSELLGRRWPLLLGMFGFDLFMIATATAKDTQTLMLCRFFAGFCAASIIALVPASLSDVFNNHQRGVAIAMYTMSVFTGPFTAPFIGGYTASSYLGWRWTLYVPAIVGFFCLALIVFFTTETYAPIILVQKAAILRRQTRNWGIHARQDELEIDFKELVTKNLARPFLILFTEPIAFLLTLYMSFIYGLAYALLEAYPIIFEGTYGMTGGTAGLPFIGLIIGEIAGSTFVLSLSGQYSRKLAANNYVAVPEWRLPPCIVGGAVFAGGLFWFGWTGWNSNIHWMAPTAAGVAVGFGLTSIFMQCFNYILDTYSKFAASAFAANTMMRSMVGAVFPLFTRQMFNNLGIQWAGTLLGCIAVVMIPIPLMFYLFGGRLRQKSKLAPVMDLMPPVEDDLKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4Y4</accession>
    <name>A0A8G1R4Y4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_416791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517481.1">
        <property type="nucleotide sequence ID" value="XM_025657750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4Y4"/>
    <dbReference type="GeneID" id="37161152"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="707" mass="77864" checksum="A67F6FF2F884F343" modified="2022-01-19" version="1">MGDNHDSSFLYGYASSNRFYGSPEPPFNPKAVTQASWTRPEPKPELKGPLVDHANTLPDVQCNTPSAKPRWKPMSPKTKGRVVYGRKVQLGLRILALAGAIGSLFCSIVIKNAAITVIWIVRVGPAVAILHTLYGIYTLSRSSITRPPGSQASYMFFAATFDLGLIPFYVFAAYLGYGQYTNNAYDWTTMLGSNVETTTKIAETTFLLGIINGALHAISFGISIFLGTIFRKITRLPPDMNPLEDNLTARPFSRTKSEIIEKRASKSTLGSDNIFSEDPLIGVPRSVPFMETRSNPSFNNDYSRFPPTFTDRTPPQPTHSFHRPSRIDTIPHLPFHQPNDIDDATTIASPIENPDIFTRATTSIPRGAPVREPSPDLPNRSQCVSPASENWIVYPSRSTTPVEETKDEHPAPRDPSSVYSRAETPASSKGGVMDWFSPQRYGLNIGEAISENKRGEYESVAANEYYGNDDDVHDILYRSGFYDNAEQDLGDHRIDIFQDHEELDEDTRNSLKVNPLALNPPSPLPRPDEVQNRTPSNGRMALTDIPNLSPKPPADEPLLDSLQKKGSFYGELPDQFGLNAPRKVSRDQSKLTPKKDKLSIKKSQKFNAYGALKQHDDGDLNGLGIPSADPMTIDGDRKGRVVSNSGADATHANSALSYGNYIAGLGVGRRRDVSGKIAEEGRVEITKPKNENTTPIRAAGWARFAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4Z5</accession>
    <name>A0A8G1R4Z5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_486969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517295.1">
        <property type="nucleotide sequence ID" value="XM_025663422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4Z5"/>
    <dbReference type="GeneID" id="37166824"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055080">
        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF1">
        <property type="entry name" value="GALACTOSE_LACTOSE METABOLISM REGULATORY PROTEIN GAL80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22685">
        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Gal80p-like C-terminal" evidence="2">
        <location>
            <begin position="144"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="385" mass="41449" checksum="76ACD8C09C9A0007" modified="2022-01-19" version="1">MSTTPRRTGLIGLSSSAITSWAADAHLPAIRSTAGRELYQITALCNSSVAAAESAIRTYQLDPTTVKPYGNPDDLAADPAIDLVICNTRVDKHYETVLASVRAGKSVYIEWPIASSLAHVDDLLAVARASGARVAVGLQGRFAPAVLKVKEVLRSGQLGRLLSTEVRGFGGTFDRDFLPPGLKYFSQKEVGGNPIVIGFGHMIDYVQSVVGNVVVGTDEARTQIQRPRIRIRDPQTREIVEEVDSDVPDLLSVHGSLPESPYTVPGASLVAYFARGQPFPGDPSLSWTLNCEAGAIRLSAPAGISLQADAYQNPATISVHHHATDTVEAVEWSWSEEQLEVPVRARSVQRTLIDFAKGNPDGYVSLEDAAGRARQLARWLDGSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R655</accession>
    <name>A0A8G1R655_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_265240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517124.1">
        <property type="nucleotide sequence ID" value="XM_025655046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R655"/>
    <dbReference type="GeneID" id="37158448"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="98" mass="10966" checksum="599400176396A034" modified="2022-01-19" version="1">MHAGTTAKHTYSAFLFGRGPGRTLLYVSSILYYLRMYLVLSYNDHTVASYQQFLISFSFQQADESLKRMQPSCAVRVVSGCSSHARCSKGGQVCIIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6E4</accession>
    <name>A0A8G1R6E4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7708 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_485994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517443.1">
        <property type="nucleotide sequence ID" value="XM_025663359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6E4"/>
    <dbReference type="GeneID" id="37166761"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619:SF3">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7708" evidence="1">
        <location>
            <begin position="85"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="603" mass="67565" checksum="1D8363546CB45F76" modified="2022-01-19" version="1">MHIVGRYAQYAELGSMLDPAVRFDTATQRFIPASPEGDTHIAVDQVAAKYKNSEAEKGVWNQIRNAFRKLGDHENAINGWLGLLPSESNYLSVVCGGLKFILHAVARAKEVRNAIVGGLRDIPILLGGAQRVLAIYKTSEPLRACSDALYLAVLTALGQMLAYTQKHTLKKALGAIMRNSSFQMAMTQSIEDVRECKDKFNEEANICSMQMAIQIERSLQGIDKTATGTREMLEDSMELICSEVRRTQALQAHDNKTIEEKIDRSNQLNEKINSKLNALLVLFECNPQLADEAYVNSQGFYAPPPYAMMSYVSGHTSHRVAQEASVYSQRDLRAIVRSRLIYEEHRAQADVVANYQLAGRLSLEDQDRCVYVIRSPELAAWIRTPTSSILVVNGNAPRNQYQTPWTFTAARLIYTLDMMRAKNSDNKDQIAAVHFFCGEHVDTSSELDFPTTIANEILSQLLSSFKHIDLVPLLKMGEFDGDDMQAVCQRIECFLDLLPATAVVFCIIDGLSFYLADEQTSERANELLRWLIKLTRHQQKARKHLEVCTFKLFLTAPRQLQGSYVTELKADEVLNVPIRPPRTGGFTEMKWETGAGGQLGMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6G5</accession>
    <name>A0A8G1R6G5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_486024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517473.1">
        <property type="nucleotide sequence ID" value="XM_025663364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6G5"/>
    <dbReference type="GeneID" id="37166766"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="134" mass="15075" checksum="66017AA32E493368" modified="2022-01-19" version="1">MDAAHEAIGTANTVDEVRLWLQTNLFQPHFLTYYKAAILPRQQAGTLKRGESFLTITNKLEAAKQAGDTKYSDHYPDTIDWNFEDHSARCLQTIVDVNTNNADGLFYRHGKSTEGYVIFYAGGPITWSSSKQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6U1</accession>
    <name>A0A8G1R6U1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_392486</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518501.1">
        <property type="nucleotide sequence ID" value="XM_025656847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6U1"/>
    <dbReference type="GeneID" id="37160249"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000001">
        <property type="entry name" value="Fungal specific transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="680"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="747"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="693"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH60579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="807" mass="88205" checksum="E596FBC3057F2EDC" modified="2022-01-19" version="1">MTSPYQPSVSYSPSVAGPDMTASGPSTASSRPVSDLPQSQVDAIIRTKRKAREPKACYPCHARKVKCDRNLPCDGCVKRDHADLCSYERPSKKRVMTGSLPQSYPDGPIPGSQPTGAENLGYAPEPPVRLKQEPGVSRPSITAAGGRVSIAREEWDNVRTRLKEMEQTINNLRVGLEKAEEGPASTLETSSVRSGDASNRSKGASPEREGIHAPNTFGEGTVHLGSRSVLAYILNNKSGSDQLQALLEGGILPKLGLDNESATYPFVDLWSSDMSSFDISAVCSALPSDQQCKEFFYYYRDIAGAIYPVLEDVPQFEMNLDLMLRNRAAMGGMYRADADQAQKPFGVTIAYMGLLFAVLASGCQSSDLPGKERELTSQVYVCCSYQCLRMTNFLSQPTIDAMQTLLVIGNVLSYNMNPGISYVLLGMTLRMGLALGLHVESGHFTAAERYRRRHVWWSMAWQDSHFSLSYDRPSTTAVSQPEIAYKDDRKPGELSYFETLCRIISLALEVVRSRMLSPHSQLSYKTIQTYKERIQQIMIEAKPHLRDRKYCLSATEHLERVVLKLHSSYFSSELCRPALKANADISDPALSNMRTDCVSNLMTTVEAYVEMHTVSSHASRSWIALQRAISSIFLLAVTEEVKGHSRFWTLLQQLKMIIAERANIEGDYGAATEAAAVPPVDSSARLGAPTRPPSTTAPSPAGLNSASPASAAVAVDTQTQWAKPLTKTLRALEKLEGAFSAQAARASQAGSPNYLNPGMGVPPVSASMTPSLGSLPPPTPESSTSGEWTIPNILDRAQEYIHPPLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R726</accession>
    <name>A0A8G1R726_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_392909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518685.1">
        <property type="nucleotide sequence ID" value="XM_025656861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R726"/>
    <dbReference type="GeneID" id="37160263"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="35"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="320" mass="35771" checksum="60893D7F1BAADB8C" modified="2022-01-19" version="1">MSTNPLYIGTHIPIGPHKLYLHLHGPPRTNQPLTIFLAGAGDVSSSYTAVIRLLSPLAPCLVYDRTGLGRSDAPDQATSYKPSATLAASELHTLLTNAGLPPPYVLVGHSYGAVIAREYLHLYSDDISGMVLVEGSTEHQYTLFDDNPNLDSDIAAVLGEMNFATVTGLRENAKISREEWRERARDIARGMGMWEAERENLVGVCRELEGKRQLQLQGGGLGERPLSVVVGRGWEDYQRVYERGVEMGNGSDEQREAVRRFLGRCGEVVREWQREQLRLSRRARLVEVDCGHQVHLVRPDVVVEEVRWVLEMIERSSSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7I3</accession>
    <name>A0A8G1R7I3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_363589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519448.1">
        <property type="nucleotide sequence ID" value="XM_025655663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7I3"/>
    <dbReference type="GeneID" id="37159065"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32811" checksum="12AD87098082D49A" modified="2022-01-19" version="1">MLLPSALPSDMPQQSTQSHLAPNLLFNTPPPTEDDLFPSGNGLLGTSRALQSLLNISPASVPRRKTPPRLLSPLQLRSPPPSRSQKRVAQKKDLTNLTRSSPSPCSPSKLPRRANKRNRSAYEIDLDSEIEDRKPSKNAKSRDRFSTPKRRRQIPNDLPLGLTQEDFYSLYSPPITQSPLSPAHRPQEDLSASEINPLEISLYNPDAPLPSIETNDESIKFASHELTPIDASPSWVAEDDRRLVNLVLERYQFSEQVLDDCARELGRNHESIRRRWQTLLGQGEIGFATMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7I7</accession>
    <name>A0A8G1R7I7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_517186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518876.1">
        <property type="nucleotide sequence ID" value="XM_025664890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7I7"/>
    <dbReference type="GeneID" id="37168292"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF81">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH60954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="560" mass="62720" checksum="FE5A507F536F512E" modified="2022-01-19" version="1">MSQAKSKLVCGIDYGTTGTAAAWGYGTDEQSIDSPIYQVDEWPVQSWAKLPSTMQYPSGMQPRWGVEATPELETFRWTKLLLDPDLESTDFRDEELERVSRQQIMRLPAGKSAVRVVADYLSGIRNHLEQSYIFSQPNIKKEYWFSIPAGWSNDAQVRMSEAIHLAGFGQKPNEEVCLVTESEASAISILEASGERRKSGSTFCVCDVGGGTVDIACYMITDVTATSYSLTELSSAIGPKSGSTIIDREFLKLMRHRFNASFVNPLNDDKSDRRERLMNDFRKRKEKFTGDGSNHRLKFRMECFTSQWYDSTAGHIILSDSDMRAFFGTVVGQVFHHVNDQVDKATRGHFKIDELLMTGGLMRSKFAREAFSEGLKDAGFSRILFSEAPELSASLGAARKALSGIVTKNQTCNKSYFIECSGLREEPGICLQAFIDEPDAPAKPQQILVKGHVYEEDKPYKTVFHLYSRPGEPPVKTFFLKMSDGQNSRVLARLTCNLSDIPTDERALQPAAAGGVYSHQCIFVTATFRVKGYLEIKVHTKCKVLAQKRVPRIWSERAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7R9</accession>
    <name>A0A8G1R7R9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">xyloglucan-specific endo-beta-1,4-glucanase</fullName>
            <ecNumber evidence="7">3.2.1.151</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Xyloglucanase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Xyloglucanendohydrolase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_113657</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes endohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan with retention of the beta-configuration of the glycosyl residues. Specific for xyloglucan and does not hydrolyze other cell wall components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>xyloglucan + H2O = xyloglucan oligosaccharides.</text>
            <dbReference type="EC" id="3.2.1.151"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.151" evidence="7"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519568.1">
        <property type="nucleotide sequence ID" value="XM_025653856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7R9"/>
    <dbReference type="GeneID" id="37157258"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033946">
        <property type="term" value="F:xyloglucan-specific endo-beta-1,4-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034060563" description="xyloglucan-specific endo-beta-1,4-glucanase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH61646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="248" mass="27041" checksum="F2C5B529C39A2309" modified="2022-01-19" version="1">MNRYLSIPLCLASAVPALAGLAARDPIGTICTKNNIITTDDFILYNNLWGEDYATSGSECTYLDYDSGNSISWQTSWTWAGGDDYVKSYPNAVLNVGAKQLSTITTIPSTWKWSYTGDDLVADVSYDAFLATTDSTTATHEYEIMIWLAAYGGIEPIGNSDGPIASPTIGGHTWDLYEGPNDWTVYSFVARETITDFSADLMEFFTYLVDNEGVSSSLYLQTLGAGTEPKTGSDAWFTVAPYTISINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7T0</accession>
    <name>A0A8G1R7T0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ABC multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_390890</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519075.1">
        <property type="nucleotide sequence ID" value="XM_025656788.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37160190"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001601">
        <property type="entry name" value="ABC multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="760"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1181"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1211"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1254"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1292"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1446"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="134"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="842"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH61153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1473" mass="164682" checksum="BF601580A7FCEBC8" modified="2022-01-19" version="1">MAPDQTGPWSQDEDHLLRQNTPNTQHTHNEEDPSHPSVALIGPEERQNLVRIATHESMRRRSSVYTQHTAVSGRPDTMGTIREDDPCLDPQTDKFDLGKWLAYGLGEFRQQGALDLRPGIVFKNLSISGTGAAVQFQDTVASTFSAPFRIGEALRNRHSPPKRILNEFNGVLKSGELLLVLGRPGAGCSTFLKSLCGELDGLTVNDDSVIHYNGIPQHQMIKEFKGEVVYNQEVDKHFPHLTVGQTLEFAAAMRTPQRRIKGLSRDEHAKHITKVVMAVFGLSHTYNTKVGNEFIRGVSGGERKRVSIAEMTLAAAPLAAWDNSTRGLDSATALKFVEALRLMADLAGSAHAVAIYQASQSIYDIFDKVSVLYEGRQIYFGPTSEAKAFFERQGWECPPRQTTGDFLTSVTNPQERRPRAGMESRVPRTPDDFEAYWRQSPEYQKTLSEVASYEKEHPLHGNKVTDTEFHERKRAVQAKHTRPKSPFLLSVPMQIKLNTKRAYQRLWMDIQTTVSTVCGQIIMALIIGSVYYNAPNDTASFTSKGAALFFAVLLNALAAMSEINTLYAQRPIVEKQASYAFYHPATEAIAGVVSDIPVKFALAVAFNVILYFMVNLRREPAQFFIYFLISFIVMFVMSAVFRTMAAVTKTISQAMSLAGVLILALVVYTGFVLPVPSMHPWFEWIHYINPIYYAFEILVANEFHGREFPCSSFIPSYADMNGSSFVCSTSGSTAGEKLVSGDRYIAVNFRYYYSHVWRNFGILIAFLIAFMAIYFLATELNSSTTSTAEVLVFHRSQKRALSRATGPKSADVENGVELNTIKPTGTEKSENLGGLAPQQDIFTWRDVCYDVDIKGETRRLLDHVSGWVKPGTLTALMGVSGAGKTTLLDVLAHRTTMGVITGDMFVNGKGLDASFQRKTGYVQQQDLHLQTATVRESLQFSALLRQPPNVSLKEKYDYVEEVISMLKMEDFAEAVVGVPGEGLNVEQRKLLTIGVELAARPKLLLFLDEPTSGLDSQSSWAICAFLRRLADHGQAVLCTIHQPSAVLFQQFDRLLFLARGGKTVYFGPVGENSRTLLDYFETHDAPRPCGEDENPAEYMLEMVNNGSNAKGENWFDVWKQSSESQDVQVEIDRIHAEKQNAPAEEDSEWSHTEFAMPFWFQLYQVTYRVFQQYWRMPSYVLAKWGLGVFGGLFIGFSFYHAKSSLQGLQTVIYSIFMLCSIFPSLVQQIMPLFITQRDLYEVRERPSKAYSWKAFLMANIIVEIPYQIVLGIIVFACYYFPVVGIQSSARQATVLILCIELFIYTSTFAHMIIAAMPDTVTASAVVTLLFAMSLTFCGIMQSPSALPGFWIFMYRASPFTYWASAMVSTQVSGREVVCSSSELSVLDPPTGQSCGEYLGQYAELAGGNLLNPIATTGCEYCSVSTADAYISMTGIVASDKWRNFGIFWVYVVVQIAAAAAFYYLFRVKKWRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7W6</accession>
    <name>A0A8G1R7W6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_273735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516297.1">
        <property type="nucleotide sequence ID" value="XM_025655121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7W6"/>
    <dbReference type="GeneID" id="37158523"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="303" mass="34147" checksum="9024AD7B4DF3ABCB" modified="2022-01-19" version="1">MHKPSLAQIVHSTLFPRPRASDPATFSAHITRNLVPEVRVETSTFYGSLDCPEAQYPGLDYSYGPHRMRLGRFPWHRRLFRAFDELGLTETEISSLCRWEGTKSARERYEKEEGVKVRDTTADNIRPASPSPLPSIEVHYEDETEEEEDEFLPEPEYPVVTFETVRSTSSLIDDRGIDCIVEEKEEEDSSDDEMESCGVELNHRLIAATAAREQGADVSLDEDWEQWLKEAGERGSYTDVLSAIRMGQPLGYLYDTSPPMPPVGRVGGRSSASLSEPFVLPTPSMLSSRGIQRYAHSSSRTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R849</accession>
    <name>A0A8G1R849_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_192790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519206.1">
        <property type="nucleotide sequence ID" value="XM_025654445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R849"/>
    <dbReference type="GeneID" id="37157847"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH61284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="80" mass="9340" checksum="B6B44E4FC7C461BE" modified="2022-01-19" version="1">MDEGGFNHCCLPWPPDMHRRNDPPESCKMNLLRCCLLEWNRLSRLLLPPTLLFMMIVVSLPSHHIFHPFVTGERASWRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8D3</accession>
    <name>A0A8G1R8D3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenases/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_510578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517592.1">
        <property type="nucleotide sequence ID" value="XM_025664552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8D3"/>
    <dbReference type="GeneID" id="37167954"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="335" mass="36649" checksum="6BB729E6942B2EF1" modified="2022-01-19" version="1">MVVLADIQSSNAQIATSLPEGMVALFVGATSGIGEATLKQFAKHAARPRVYFVGRKHEAANRIIAECETLNPEGKYIFISADISLLCNVDEVCRDIKARERALNLLVLTPGIATIHNETPEGLRKITSLLYFARMRFIVNLLPLLQQATSLRRVVTVGAAGSEGPIDTTDFEGRKLSAPLFRGHITSLTTVAFEKLAEKAPTVSFINTHPRAVQTGITREVDNVRMWIVWLALLLFGRWICIPAIESEERHLFVATSAKYPARDGDDGVPLSEGVAVARGIDGMLRGGVYSVTSDGESSDNAIKVLKDLREMGIGEIVWRYTESQFKRITGVNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8E4</accession>
    <name>A0A8G1R8E4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_517711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518041.1">
        <property type="nucleotide sequence ID" value="XM_025664927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8E4"/>
    <dbReference type="GeneID" id="37168329"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="2">
        <location>
            <begin position="125"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="358" mass="40589" checksum="E404B46B0D889179" modified="2022-01-19" version="1">MAGEWFRRTPARENIEANDREEAGQVRTEDESIEASRTEFCESDESLPLSESTSGLMRRYRIVTDLSNRLIEARPRVVFRAHYVVPGFENALPLLDSKAPDSNHVYGLIHFLKHGEPAWTSDGFEHEMSKVISAYYRCAKEGRSKGSWVMDYVRPLLDLAIDDLPLESWSVQAEPVRDKYLPAHSAREMFNHNLDLVVGLPKEPWKECYRLAGIDIPDREMSHIEHAHTGKRLLGLGVKVKGLNGTSAEARVQLGVWMAGLMSWAHDSYRHVCPGIPPPPIIGCTVVGPIWKFYIIYAMGCSSGALKDVYVWGPIPELEGDATSRKCMLEFVITLNRVMKYIRRDYAPLMFGRLNLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8I8</accession>
    <name>A0A8G1R8I8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_364994</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519185.1">
        <property type="nucleotide sequence ID" value="XM_025655722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8I8"/>
    <dbReference type="GeneID" id="37159124"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="403"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH61263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="764" mass="88707" checksum="234183867EB74A27" modified="2022-01-19" version="1">MPALIPQIPHKDDLDETWTFLEKGIDSVMLKLEEGVDMKTYMALYTAVHNFCTSQKAIGSSQNIKAHHGAHLLGEELYKLLGEYLSRHLDAVYQESEGHAEEALLGFYIREWLRYTTAAKYINHLFKYLNRHWVKREIDEGKKNVYDVYTLHLVKWKDDFFMKVHEKVMEAVLNLVEKQRNGETIEQSQIKSIVDSFVSLGLDESDSSKSTLEVYRYYFEKPFIDATRVYYENESRQFVAENSVVEYMKKAEARLDEEKARVGLYLHPDISKHLTDTCLDVLVTAHSELLRDEFQVLLDNERQEDLARMYRLLSRIKDGLDPLRTKFEAHVRKAGLAAVEKVAADGESFEPKLYVDALLQVHTRYQSLVSEAFNGESEFVRSLDNACREFVNRNKICKSGSTKTPELLARYTDSLLKKGSKAAEESELEEMLVQIMTVFKYIEDKDVFQKFYSKMLAKRLVHVSSVSDDAETSMISKLKEACGFEYTNKLQRMFQDIQISKDLNASYRDWQEKILDDDDRRKLVDSHFQILGTGFWPLSAPSTDFLAPPEIVKTAERFQSFYFDKHNGRKLTWLWQLCKGEIKTNYIKNTKVPYTFQVSTFQMGILLLFNEHDTLSYEEIQKATSLAPEILDPNLSIFLKAKVLIINPEGSKPEPGTSFSLNYNFKNKKIKVNLNIQIKSEQKVESDDTHKTIEEDRKLLLQSAIVRIMKSRKKMKHVQLVQEVIQQVKSRFPPKVPDIKKNIEALMEKDYIERLDGDEIAYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R996</accession>
    <name>A0A8G1R996_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_516460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519821.1">
        <property type="nucleotide sequence ID" value="XM_025664846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R996"/>
    <dbReference type="GeneID" id="37168248"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053025">
        <property type="entry name" value="Mito_ATP_Synthase-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="54"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH61899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="304" mass="33268" checksum="7412ED67E7ACD036" modified="2022-01-19" version="1">MTFPRLRGPTATRLRQTTITSTPYTNPIHHHHHHSIRTFTSSTLHYSPSAREPTYYEILDVPPTATQAEIKKKFYALSLQHHPDRNRDDPSASNRFAQISSAYNTLSNATKRSIYDRDHHIHIHASSTHSTATPGQHPMGSYSSYSANLHTKGASYAGSRPASGLSKRRGQFRGPPPSFYAHGGYGGTGRRAGGEGGGGGSAKGTAEDDPTSFIHRNTVWHFNAKGHYRTQTREDERRQERRSREMAGASHINDKYLGSPGAMAVRFIVVCGILMGAGAMTGVWNGDRAGGQTKSTKSVGRKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9F8</accession>
    <name>A0A8G1R9F8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_484050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519960.1">
        <property type="nucleotide sequence ID" value="XM_025663207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9F8"/>
    <dbReference type="GeneID" id="37166609"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="94" mass="10344" checksum="12239B4CD42D4A5D" modified="2022-01-19" version="1">MSFFFCSSTVSSTGARVIDAKNNRSDGSWFEITGFKVKSGKNAKVGPYCQAFTDKKPGNVCSASIKVIGNWGFDVAEYAYVYNHSTKKFDYVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9R4</accession>
    <name>A0A8G1R9R4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc-regulated transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_448273</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517272.1">
        <property type="nucleotide sequence ID" value="XM_025659898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9R4"/>
    <dbReference type="GeneID" id="37163300"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000006">
        <property type="term" value="F:high-affinity zinc transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF32">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH59350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="356" mass="38980" checksum="F15C499F57717D92" modified="2022-01-19" version="1">MAIFNASEVNLHTASKEDVLCYYAISENDYNGHMGARISSIFVILFVSTAFTFFPVVAKSMPRWKIPHNVYIFARYFGTGVILATAFVHLLDPAYKRIGPKTCVGVSGNWSLYSWCAAIVLGSITLIFLLDLAAEVYVENKYGMHREENATDAFISGDPTSAHIHPNPEDGRMSAEKTSPTATSAETSSEQGERSFRQQIAGFLILEFGIIFHSVIIGLNLGVTGSEFSTLYPVLVFHQSFEGLGIGARLSAIPFGHRKWLPHLLCLAYGLTTPISIAIGLGLRTAYNPGSKTSLIVQGVFNAISAGVLIYSALVELLARDFIFDPCRTRRRSKLLYMVFCTLLGAGIMALIGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9X8</accession>
    <name>A0A8G1R9X8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_466029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520196.1">
        <property type="nucleotide sequence ID" value="XM_025662105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9X8"/>
    <dbReference type="GeneID" id="37165507"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000052">
        <property type="entry name" value="Phosphatidylglycerol specific phospholipase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF24">
        <property type="entry name" value="PHOSPHOESTERASE SUPERFAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G17590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034037707" evidence="2">
        <location>
            <begin position="19"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="454" mass="49692" checksum="8A5B437CAA9A2715" modified="2022-01-19" version="1">MHPSALVGLLAFAAAASAIPANPSHQAHSDSAIQNLKSKIKNVVVLVMENRSVDNLLGGQTIKGLENPINNGPFCNPYNITDLSQGTVCSAARDYDSVTDDPDHAVYGNNIEFYGTFTPDNAAIAQGKLAPSQQGFVTEQLRLYSADANRTELSVQVMNYYTEQQVPVLTELVQNFVVFNHWHSDVPGPTNPNRAALTSGTSYGHGTNDEAFDNHAFPQRSIFQQLTETGHSWINYWDTAGGTGPDAEFYDWTYTSNNTNKVKALETFYTDAAAGALPEFSYVNPSCCGVGTNSMHPSGLISDGEKLIKNVYDALRAGPQWNETLFILSFDETGGFHDHVPPPLAPRPDNLTYTATTPNGKDYTFNFNRLGGRIPTLLISPWVGKGYVEQKGTSITGDTVSYSASSILRTLGYLWDFDPFTPRVEYAPSFEHLVQTRSRDNTPTALPSPVPFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA54</accession>
    <name>A0A8G1RA54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_416352</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518597.1">
        <property type="nucleotide sequence ID" value="XM_025657728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA54"/>
    <dbReference type="GeneID" id="37161130"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH60675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="242" mass="26504" checksum="1F3AA271D64D9AC7" modified="2022-01-19" version="1">MICQRCRTGILSRLQQPQTVTLSIPSRARQFPIQRSQFRNYSDGKPTVSATPPPPTPRQPAGADITIPSAVSSATPGVSQPLSTPEGVHADVNPEKPKKAAVERPPSSCAAGQKMNGLNYFKNKPDVVALEDAEYPEWLWSLLDDSKKNKTATGGVDPSTLNKKQRKRYEKKMAARAATLPPQIPIHHHATDITPAAYNADAIPADVLEAAAESLDKRTEIRRSAREARRKGIREDNFLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA89</accession>
    <name>A0A8G1RA89_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_413169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520085.1">
        <property type="nucleotide sequence ID" value="XM_025657596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA89"/>
    <dbReference type="GeneID" id="37160998"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF2">
        <property type="entry name" value="SYNTHASE, VITAMIN-B12 INDEPENDENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="1">
        <location>
            <begin position="186"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="408" mass="46513" checksum="1AF1BF1C57AC2D56" modified="2022-01-19" version="1">MANQLHSAPPFRAEHMGSLLRPDNLLAVREKIRDTGISEQEAGLQAVEEETVRDVVKLQRDLGYKAVTSGEFNRTRFWGQMWDEFEGTIRLQDAEASMFRLYHPDVVSLIEKDRKVMPGDSVIAGTKLSWNPEKSVSNLHELKLVQQALPESEWHTIKLTMITPAWFHMRYKQGKAYTPEAYANDEEYFQDVAKVYQAELDALYKAGLRNVQFDDPGMAYFCSKAFRQGWEEDKDNIGTVEDLLDAYIKLYNDSVSKIPADMHTGIHLCRGNFIGGRHFAEGSYDIIAKKLFENLNVNTFYLEYDTERAGGFEPLKFLPKNKNVVVGVISTKLRELEDKEAMKERIYKAADFVSAGSGETREEALKRICVSPQCGFSTHESGYPLSLEDEKKKLGLTRQIADEIWGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAH5</accession>
    <name>A0A8G1RAH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_435484</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519106.1">
        <property type="nucleotide sequence ID" value="XM_025658528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAH5"/>
    <dbReference type="GeneID" id="37161930"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF156">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="34"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH61184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="353" mass="39674" checksum="8003882C8370A511" modified="2022-01-19" version="1">MDEYSEERLHQSKQHLIITVSIVFIVLEVVCVVLRFTSKFVERLKFGWDDALMVVGLILCVADASCTIAAVKFGGVGLHQEIVRQIDPEMLVTATKFLITTPLLYFATVVPPKLAILHLYLSIFTDKMLRKICYGTGAVIIINWLVVTIAGVVSCRPLSYYWTFHGSCIDINAWLRWGGFAHILTDVVMLILPMPVVWNLHASSRLKLGIWVTFLMGSVGMVSSIIRFREFYVTDVQGDVTWAASTLVIWAEIEGGIYLIAACLPTYRPLTKFIWRRVLRKRSQTGESLHTGTGHRASQLRPGLGSTHNESKFPWMEASRSEEDVLRMVTLGSRSGADIKPGQIVVEHHFSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAP9</accession>
    <name>A0A8G1RAP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_183255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518897.1">
        <property type="nucleotide sequence ID" value="XM_025654363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAP9"/>
    <dbReference type="GeneID" id="37157765"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
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        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="219" mass="24523" checksum="2783FB44FC18FEE7" modified="2022-01-19" version="1">MNFWVGWALWQKLSFALAGLLALVLVYSFIVLAYNRRKTQKYATAEARQKAEMQPMLAEPSDIPFGARALEKGIQVEGIWTPDCRSARQSTTHSGSRPESIASAPKPTLMALTGDDIQGLERTYQPAPSPSLYDQCNSAKVLDIEYGQSDYISLSPTNQSLQLDGPIIIEPECSPDLDKRRSRWFGARSSWVKKPFDSYKRRSTPEGKILKYIGLDSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB51</accession>
    <name>A0A8G1RB51_9EURO</name>
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        <recommendedName>
            <fullName evidence="10">G2/M phase checkpoint control protein Sum2</fullName>
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        <name evidence="8" type="ORF">BO85DRAFT_484942</name>
    </gene>
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        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FDF_dom"/>
    </dbReference>
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        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF09532">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="4">
        <location>
            <begin position="400"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="5">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="6">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="319"/>
        </location>
    </feature>
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        <location>
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            <end position="404"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="476"/>
            <end position="562"/>
        </location>
    </feature>
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            <end position="479"/>
        </location>
    </feature>
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        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
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        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
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            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
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            <begin position="150"/>
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        </location>
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            <end position="203"/>
        </location>
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        </location>
    </feature>
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            <end position="394"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH61200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="58750" checksum="313D72A7D31FF4B5" modified="2022-01-19" version="1">MDMNHLIGQRFNLISKSDIRYVGTLHEINPEASTIALENVVSFGTEGRRGNPAEEIAPSASVYEYIVFRGSDVKDISVAEDTKENSQPEPPQVPDDPAILGSMSRPGPTSQGLPPSQQPQVPRPAPPGYPQQPPFQGFYPPYGQRFGAPGFPPGPGFPNMPYGAPPPGWFPPPGQGFPQGPGQFPPPQMPIGPPGQHQTPPPQRQGVPGAGPVNVPKPTSELPVGDRPSSKPASRNATPAPGVSAQNAPPPPVESKPSVTEAVQASSIPAAAAAPTPAKMPPTGPRSGRVQPAIPINAPSKPPVPAVGNPPVAGAGSSVPQGTAQAAITEATRAATAAVAAAMAKLPQPNAPKKPAHGEVSVEGVTRQMAEMKPYEGNRAPRGHHQHPRGRGGHRAPYQGQSKKVEVPDTDYDFETANAKFNKQDLVKEAIATGSPVHEAETASITNGDIEAPDTSADASSVATYNKSTSFFDNISSEARDREEGTGGRVGGREWRGEEEKRNIETFGQGSVDGYRGSYRGRGRGRGYGRGRGGYGRGYSRGRGGLRGGRNTSQATGVPTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB59</accession>
    <name>A0A8G1RB59_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_482536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="211" mass="23539" checksum="A20B8BA0D0AF18B0" modified="2022-01-19" version="1">MPSSRSILQTYRLISQRKPSAHRLFSTPPPPPPPSAKDVRSRLHKLNDRLPASVRPYTTPLLGAPATHITSFLILHEITAVISLLGLVAAFHYNNGLLPDMSSNQLFEEQTQKFGRWLRKKGWVEEVDVDTVAEEYGGDSAHHHGEAERSAWSVQGEREGVRLILEFATAYLITKALMPVRIVVSVWATPWFSRAVLSPLGRAARGLFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBJ4</accession>
    <name>A0A8G1RBJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_494869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025663882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBJ4"/>
    <dbReference type="GeneID" id="37167284"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034345863" description="LysM domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="108"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="226" mass="24133" checksum="6A077D022E0AECFF" modified="2022-01-19" version="1">MHFLSLAALPFLASAATAAPTCNRSHLNSTVGLYTVQEGDTMASVSNTVNRGICDIARLNRMADAMIPFLTGEQLLIPPETCTPDNSTCLLFPSKIDNYAECVSGGPHTYYTVKGDTIRTIALRLNITVDALSATAQGGVSDPDAPVQVNNELKVPQCSPSVCEVEPYQLIYGTYKDLADKFGSTVGQIMAFNPTYNHSDVARGEAAVITLPKNCRNLGDNVTVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBW0</accession>
    <name>A0A8G1RBW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_494185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520744.1">
        <property type="nucleotide sequence ID" value="XM_025663862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBW0"/>
    <dbReference type="GeneID" id="37167264"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH62822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="318" mass="34916" checksum="751382DA41678C6F" modified="2022-01-19" version="1">MPGLTPAQLSTFNTTGYLIIPDYLTPTEISACLTETNNLLTTFPLDTHPLTQFTTGDSSSPTDKHVGDTYFLESGDKIRYFFEPSAICPTTSTLLKPKHLAVNKIGHSLHTLSEPFKSITLSQRNAEIARSLGFKDPRVLQSMVICKQPGIGGAVPPHRDSEFLYTDPPSAVGWWIALQDAGKGNASLGMVRGSHRRRDGGVGRRFVRVYDNDEDGGEVVGTGFVENEGGRFPRGLEVDDDEGEGEGEEVEVVDVKAGSLVLIHGNVLHKSERNTGDKSRFAYTFHVIEGAEGWEYDGRNWLQPTGEGFSRLYDDHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC22</accession>
    <name>A0A8G1RC22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiosulfate sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_445109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519602.1">
        <property type="nucleotide sequence ID" value="XM_025659179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC22"/>
    <dbReference type="GeneID" id="37162581"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="43"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="183"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH61680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="307" mass="33833" checksum="E9D1D61207643734" modified="2022-01-19" version="1">MNPFQSPLITPVEYHHNAAVCNATKRRRIVPLAAYRPTLHSSFESFHLPGSKFFDLDQIRDTASPYPSMLPLPSLFAAAMTALGIRNDDILVIYDADEIGTYHAPRLAFMCELFGHKDVHVLNNFRQYVRMRLPVDSGSEGIEVPVVGKRGEQGDEYVVEGRDFDTGRVIAFEEVKDVVVGRDQEKVRIVDARIPGRFQGVQPEMTPSLRSGHIPGAVNVPLASLLEAETGMILAPEKLRGVLTDAGALAEEDEGVPYILTCNSGVTAASLDLALRLVGAKGSRRVYDGSWMEWTRRVGDELIEVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC58</accession>
    <name>A0A8G1RC58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S28e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_413479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520274.1">
        <property type="nucleotide sequence ID" value="XM_025657610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC58"/>
    <dbReference type="GeneID" id="37161012"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_eS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH62352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="68" mass="7639" checksum="21E5AB2A435908DA" modified="2022-01-19" version="1">MDSAKQPAKLVKVTRVLGRTGSRGGVTQVRVEFMDDTSRSIIRNVKGPVKVDDILCLLESEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCT8</accession>
    <name>A0A8G1RCT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_444155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520743.1">
        <property type="nucleotide sequence ID" value="XM_025658956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCT8"/>
    <dbReference type="GeneID" id="37162358"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000633">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit Utp15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000867">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit Utp15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="134"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="177"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="7">
        <location>
            <begin position="394"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH62821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="541" mass="60087" checksum="B547056E54059A0A" modified="2022-01-19" version="1">MAAPVLPLQQVKLPALPSTRLTPEQQYWKTFKNPLLIPSPANGPVNLITQPSAPSSASAFPSLTQPPDVFTVTTGARVQIYSIRTRKLLRTITRFDDTVRGTDVRPDGRVIAVGDDSGTVQVFDVSSRAILKTWKDHKQPVWVTKFSPSDPTCVMTASDDRTVRLWDLPSENSQKVFTGHTDYVRSGAFMPGSLASSGLVVSGSYDRTVRLWDPRVENRSAMTFKMGAAIETVLPMPTGTTVLAAADNKIAVLDIVAGKPLHMIQSHQKTVTSLALASNGERLLSGALDGHMKVFETTGWNMVSGSKYPSPILSLRAITSGIAQEDKHIAVGMQSGLLSIKTRLSGQQKIRERERRKEMQALLEGKLEEHDRKAAKQKKQRGSGWEKRLRGQDFVGEGVDIVIEGRDLKKRKKEQPWELDLRKAKYSAALDQVLRSNDKTAQLTLLTALRHRSALRASLQNRDEVTLQPVLQWVHKNITEPRLVQLSVEVAMNVLDIYSGNLGQSAQIDKMVERLHRRVRDEVEMAHQAYQTKGMLEMLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD39</accession>
    <name>A0A8G1RD39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF218 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_27823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521570.1">
        <property type="nucleotide sequence ID" value="XM_025655159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD39"/>
    <dbReference type="GeneID" id="37158561"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055323">
        <property type="entry name" value="C57A10.07/YOR238W"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="259" mass="28799" checksum="84410576891D4D10" modified="2022-01-19" version="1">MQNQQPHSTHLIIVCCHAIYTGGPTNGQSEDEWIIEPFQKGETPTFTNHVKAGLQALANDPDALLVFSGGPTKKGRTDLAEGVSYLNLAKDNNYFDFAPRIDPAQVVAETYATDSYQNVLFSMLRFRLCTGVYPRRVTVVTHEFKRKRFVECHFPALGLSSSASTVVGINPPEEVTPLASLVAGEEKSGIGLWRSDRYGVQRELAGKRVKRGWRAGMEDGVFVNVGLEAVVEELVRWDGGENGNERFPKMEELPWWGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RE96</accession>
    <name>A0A8G1RE96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_17358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520996.1">
        <property type="nucleotide sequence ID" value="XM_025654298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RE96"/>
    <dbReference type="GeneID" id="37157700"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="164" mass="17847" checksum="482081D1F476A70B" modified="2022-01-19" version="1">MRRLYISASYTSIMKTSSTVESIRTGPGTLVSLALAIKAVVFPCHFCFLRRCAQAGQFTMARKLRNTSQLYTSDAVHSGYCKSVLLERRPVSGPNSQDVLNGALGDQLSNLVRPIIFSCHSVCDGSGAVQGWPRNEGISFLDLRPAALASGIDAREHLGHYSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1REZ4</accession>
    <name>A0A8G1REZ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_465116</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521117.1">
        <property type="nucleotide sequence ID" value="XM_025662033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1REZ4"/>
    <dbReference type="GeneID" id="37165435"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF19">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="505"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="853"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH63195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="929" mass="103275" checksum="BBE7DA0706D83F4B" modified="2022-01-19" version="1">MIVKLTQPYSFLDDYSEGAHPRLLQSLLLTNATQQTGYGTDEYTHEARQLIYSQIQATDDEVAIHFVPSGTAANLISIASCLRPYEAVLAVETGHILDKEAGAIEATGHKVIPVPGVRGKMTPENLERVLDRNTFFPHMAKPRLVYISNATEVGTIYTRSELRRLSETCRRRDLLLHVDGARLGVALSAEMNDLTLRDMVDYTDIFWIGGTKMGALLGEAVVVRRSLAEGFEFNIKQRGALLGKSRVMGVQFAELFRDGLYFELARHANAMARRISAQFERMGWELAADTETNQVFVVVPDAMLHRLAERIRFYEWDKRETGTVIRIVTAWATDEMAVKCIHDGHPPCRRCHRLNRDTCVLTDPRSSGVHATRTTATTPTASSPAPTPTPSHSANPIAAIAPATLIAACDIYRKKFPVVNFLHYPSLIADLSHNASAVEPVFLSALLSLCARFMPDAALAAPETYAEYARSQLAHRAFEAPSLYLAQSLVMISLYEWGSGRPYRAWMCSGMATYMIQSLLKTADDTMEQQPLLDLPAHRITYEQLVRTYWCCFAQDCELSSGARQHFALSFRQISVPLPISDSDFTFGKATPRLMPADMNRSSSLALNLSIDRGLTIVTRGFDIFVRILRFANESRRGRAQGSAGLSLRSWEMLKAELDEWRGLQDATVRYPETNAQAHVALGSGELFAYINLVYFMSILFLYRDRFLSTPKSFIDHHDPADDEAIDHLFATAQHIGAILAALEACATPVITPYAGFSVFVAAHINMYGTVCPGRYPGGLARAQEEKKMNLEYLERLCRFWDVGTSWWRTLQEANRFYETARTSAQGPTGVSRPEHLTLAGTLDEYGDIRVSRPETAPASRRRPGVSSEGVGVRRMSVAELTAPGGSGSSGGSGEWADVEAEMWQWPFLDENWSLGFDTGFESAWPGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RFP9</accession>
    <name>A0A8G1RFP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.216</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA 2,2-dimethylguanosine-26 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA(guanine-26,N(2)-N(2)) methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m(2,2)G26)dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_445882</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520377.1">
        <property type="nucleotide sequence ID" value="XM_025659373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RFP9"/>
    <dbReference type="GeneID" id="37162775"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 12" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="82"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="609"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH62455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="690" mass="76069" checksum="9F5693D4F65204D1" modified="2022-01-19" version="1">MAEQLIQYDGTEYRAVKEGLAYILNPPAQAPGTKRDRKADEQSQSVFYNPIQQFNRDLSVLAIRAYGEHLLALKKQKAEKRKQKAAASDLAKGKKRKREEVDVKEQTEDQNQGQGNPTTAQQADQDTAPSFTILDALSATGLRALRYASEIPFTSCVVANDLSPSAIESMKTNIKYNSLGEKIRPNTGDARAYMYSLLNQQANTPTVENHLGKFDVIDLDPYGSAAPFMDAAVQGVKDGGLLCVTCTDAGVWASYGYPEKSFALYGGIPVKGPHCHEGGLRLILHGLAASAAKYGLAIEPLLSLSIDFYARVFVRVHRSPAEVKYISGNMMMVYNCDAGCGAWSTQPITQTKQKLDKKGNPFYHFGFAQGPVADSRCGHCGSRTHLSGPMWAGPLHNAHFIRRILDMLPQADRDVYHTIDRIEGMLTTAMEEDLNLEIPSDEANQTPTGTVGGDIPVNEYSAIIPRLDPAAREEYPFYFSLSALSKVLHTSTISIDAMRGAIRHLGYRSTRSHARPNTIRTDAPWEVIWEIMREWVRQKSPIREGALKPGSPGAVIMSKSRENVQGCEGEDPSLALLKTELQAVAEEAKDVKDMVTKIEAALYRSGARQAFGRKRRESDPQREQPGTTQKGPQDTKPPRSPNGTGRPHPSTLEVVFDEALGRETAKKRLVRYQINPRENWGPLSRASGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RG03</accession>
    <name>A0A8G1RG03_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cis-aconitic acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_482502</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520527.1">
        <property type="nucleotide sequence ID" value="XM_025663103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RG03"/>
    <dbReference type="GeneID" id="37166505"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF8">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="3">
        <location>
            <begin position="67"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="4">
        <location>
            <begin position="344"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH62605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="541" mass="58111" checksum="62BA2757800125C0" modified="2022-01-19" version="1">MVAITAKSEAASATSPIPTTNTTLNGVDGPKEKEKDHQPQNKEEEGTAAAEEKVTKAYNSSNGVTSQLCTWIASLQLEDIPDSVRTRAKYLFLDGIACALVGARVPWSQKAFDAMAVFEEKGKHVVIGYEERLGAIAAATLNGSWIQACEVDDYHSVAPLHSQAVVIPPLFAAAVSARNHPTAPRIIDGRTLLLASVVGFEVGPRVGMALHGTEMLAKGWHCGSVFGGPAAAGSSAKLLGLSAGQIEDAIGVAATQACGLMAAQYDGMVKRMHHGFAARNGLLGTMLAWGGYEGIKKVFERPYGGFLAMFGLGSKHTPSSKPEEVAKDLGTFWHTAEWIRLKLHACCGGIHGTIECLAEMQEMYPERFGREKLGEIKEIHIQLSDAVFHHCGWAPETRPLTPTGAQMNTAFVAASQLVDGQVLLEQFSSGKLDRDEVWELIGKTSCVHTAELDKPNIGCGALISTTFADGTQVQHSLLKPKGVDEPISNEEILEKFRRLTGGLIGVERQEKIEKAVLGMEELQDVDELIELLSVNVVNPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGF9</accession>
    <name>A0A8G1VGF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_207570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510186.1">
        <property type="nucleotide sequence ID" value="XM_025654585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGF9"/>
    <dbReference type="GeneID" id="37157987"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000697">
        <property type="entry name" value="WD repeat protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="174"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="518"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="663"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH52264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="717" mass="79198" checksum="9B8E910307740CC5" modified="2022-01-19" version="1">MDPDAAAQPIGFVPRFPPPPKYIRVRAHYKKEKTFNRVFLAQELDGADDSASVSDHDAISTAGPQNEKYTGKAIWALVFSNDGKYMAAAGQDRKVRVWQVVASPEDRTSSEPGSDDDAPRLNAQVFRTQPVQVYAGHTGSILDLSWSKNNFLLSSSMDKTVRLWHVSRPECLCCFQHSDFVTSIQFHPRDDRFFLAGSLDTKLRLWSIPDKSVAFVATVPDMITAVAFTPDGRHSISGSLNGLCNIYETDGLKAVGQIHVRSARGRNAKGSKITGIDTMSLPHGDPHGEVKLLITSNDSRIRLYNFRDRTLEAKYRGNENTCSQIRASFSNDGKHIICGSEDRRTYVWPVGPVEKDADKRAVEIFDTQSALVTAAIMAPTRAKQVLGFSEDPIYDICNPPPVTLVSQADKENGRSNRMSAASKLAQESPTFMSRSTHPDGNILIVADYAGKIKVLRQDCAYLKRRYDSWDTHSTISRRILRRTNSARHSIASSIGKDSMKTTPSERIISWRNSVIRHGNRSGMRTPRTRSPSPHKSVRDTLPGYASPGRVSTGARPDSRSIYTTSPPPSAYKNSMDSRRSSADTTRNGHNGAAVDSRQPVAGTTWFPKGGDKDNPLWLQGEQSYAFYNKIAHDAMTVQNRKRTEGNGLLTPHRLSVPGERQMSLGSALSSDYASSNGDGDDGEVLKCDNCRGTNFRATKARNGKQRLVCVRCARPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VH55</accession>
    <name>A0A8G1VH55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_463304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510968.1">
        <property type="nucleotide sequence ID" value="XM_025661917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VH55"/>
    <dbReference type="GeneID" id="37165319"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="2">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="254" mass="28745" checksum="8CEF49C20389D8B1" modified="2022-01-19" version="1">MPKAAPYLPLLTTHLTSSPTSTSITLTTLSLPPLSATPLPRSRTVEFRGFFPTLNLHPTAIQSLKDQHLGLNPDIYESEMLALTTDKRMEKVKELESSGGVVEAVFWLREVGNMWRVRGKACIIGNPLGDGDEEERVGRGFVEKGLRKVREGEGWSWERQVDMYFANHSPGMRGTFKNPPPGTPRNQDPGHPELKLGQKVEDLKDKVARENFRVVVIRPEEVERLDVNDPSNPIRTRWTAVRDGEEWEEVDLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHQ0</accession>
    <name>A0A8G1VHQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_503623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511566.1">
        <property type="nucleotide sequence ID" value="XM_025664241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHQ0"/>
    <dbReference type="GeneID" id="37167643"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="11"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH53644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="359" mass="38583" checksum="A4433476344AAAFA" modified="2022-01-19" version="1">MQSTQSAVITLSLGHAAFVTNQPIPTPRHDEILIRTAAVALNPIDWMLLGSTPSPNAVMGHDYSGTIVEVGQSASEQYKVGDRVCGLVKGADRTRPESGTFAEYILAKAAVQIRIPDGVSFEDAATMGVGAIAAGQCLFGPSGLNLPWNHPPKENHDTILIYGGSTASGCWLIQVAKLAGYTVLTTCSPRNFDLVRKYGADAVFDYRDPRCAQQIREHTSNKLRIVCDAVSTKESVRICEKAISNKGGLYHSLLPAEMGRENVKSTFVNCCTALGEPFEYGPDCMVIPRMPAEFEFAQRWAGIVSTLWSGGKIKPLVVDKRAGGLKRVLDGLGDLKNGTVSGRKLVYTVLDDLVSAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIZ0</accession>
    <name>A0A8G1VIZ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_377654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512976.1">
        <property type="nucleotide sequence ID" value="XM_025656269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIZ0"/>
    <dbReference type="GeneID" id="37159671"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="230"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="777" mass="88901" checksum="A67CF180B9034258" modified="2022-01-19" version="1">MDETGDVSQSVVNEKTATCSLCSCLECVQNLESDGGYLSRDFKFDSLLKAQQIFFHEQCPSCDDIPNDLLCRFCKHLRPRHLNHYMTRKVALVLNFGMVQDIQQRSGNCVFCSIVIQEGCLKGCNEYSNLIMRIDSATPYKDMHLEFNFYEQGTLGVDAKCIGGILDATKRTVWQQPMVDWSTVRIWLETCDREHGGLCDNGILSSPPRGFRLIDTERGCVVMAPPSCRYATLSYVWGSTTDKNALATKRTIKMLKEEGYLFKTPIPATIRDSIRACIELKIRYLWIDRLCIVQDDTTTVKASQINAMGDIYSHSYLTLVDLEGVTMDHGLPGVSQARASHTIHKACGMSLRAIEDRFPVLLKQTKWISRGWTFQEAMLSTRMLFFTDAGVLFECSQASQEDRFGLTTSMHLHFTPVTTYRDLLFELSSRSFTINSDILRAFSGIMHWRYGTEHYFGLPYCEFVRGMLWRPHGLHDRQVPVARLTKAGDIFPTWSWSSVMGRVDLDSDESTHTSLLGVWGIPSFRANETVHIIRPHNQQLSRDEIDGWVREFGIALAWKRGCFPKPLPPMLNVSTTWKEYRALLRSGWASFDKLNEEALGLAYLQGEEDIKKIFSSSYTKHANQPGALLAHTQSLEARMIRLGHRKPETFHLTPYVHVTLHGKRDDMVDMWIYFHPDLWLFLHHDYSKKHDTKLNVLALSMSHVYDFQFGYRLRGKQGRWYDSEGSVLSAHGADSIFLVDVLIVETRDGLSRRVTTGFVELHDWISASPEFRNFTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJY2</accession>
    <name>A0A8G1VJY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dolichol-phosphate mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_381997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511120.1">
        <property type="nucleotide sequence ID" value="XM_025656447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJY2"/>
    <dbReference type="GeneID" id="37159849"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF5">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="330" mass="35651" checksum="FFF4B8E06C2FE01C" modified="2022-01-19" version="1">MSHPGILHHYAPRLVAFEFTPPNSTPSTNALLFIGGLTDGLLTVPYVPTLASALSTTTPNNKNTWSVFNVLLTTSYQGWGVNSLDRDIEDLAQCITYIRKLKGPESKIVIMGHSTGSQDVLHYLSAPNPIPHNPAVNGLQYLTRPPVDGAIMQAPVSDREGMHITITTAEARGAYEQLVGLAKAAVVEDPRAILPLNLTSLVGLDAETPVNAWRFLSLASPESPENPSQDDLFSADLGDEKLRQTFGVVGETGLLGGRLMALYSGADEYRKPGLDVEGLMKRWQKVTDEGAGEVKWDAEGSAVIEGASHNVQDVGQEELVERVRGYLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK68</accession>
    <name>A0A8G1VK68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_522227</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513307.1">
        <property type="nucleotide sequence ID" value="XM_025665247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK68"/>
    <dbReference type="GeneID" id="37168649"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clr5" evidence="4">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH55385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="306" mass="34448" checksum="24EA621FF3C2EE8C" modified="2022-01-19" version="1">MSLSDHKDTVQRLYVDEDLTLDELMDFMESNFGILASKDTYKRHFRKWKLRKNNNRDFYIWANHRLEKRSHENPKKKTQILLNGKAIDEKTIQKNIPRQVSTYDQARAAAASPATPQGYSIVTPAGFDILHSSYKDDFERVQLQLRNLPQDIYADTVRTARFIASAKGCVNAAAALFDNEPNVDSRDSKGQTCLGIAVLHNHPAMVSFLIARGANINNRRRDGQTVWTQICTSKEHGAVSQTLINVDAHVNTTVNSVNGLYIPAAGGHIDDVRRLLRRGMNRSSQTPFSWALLVTLTSETVPISIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK93</accession>
    <name>A0A8G1VK93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA mismatch repair protein msh3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_489300</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514431.1">
        <property type="nucleotide sequence ID" value="XM_025663592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK93"/>
    <dbReference type="GeneID" id="37166994"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001238">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000036">
        <property type="entry name" value="DNA mismatch repair protein Msh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000042">
        <property type="entry name" value="DNA mismatch repair protein Msh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000046">
        <property type="entry name" value="DNA mismatch repair protein Msh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000022">
        <property type="entry name" value="DNA mismatch repair protein Msh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000010">
        <property type="entry name" value="DNA mismatch repair protein Msh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="15">
        <location>
            <begin position="876"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="986"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="986"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH56509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1007" mass="112666" checksum="1132271D53A7ABFB" modified="2022-01-19" version="1">MMRAHGLHMTYLCQSQARSIARPDIFPPYRCHVHRTICHHARRPSTLLPKVTCYSVPLRGAKTKTTVKLKDLPQGALKLQPYQEVVDDAPKYPAVVQGHWNNMQKFKNCVILTRVGGFYELYFEQAEEFAPLLNLKLASKKTSAGPVPMAGFPFFQLDRFLKILVQDLNKYVAVSEEFPNAAEDKLRSGGLLFDRKVARIITPGTLIDEKFMDPSENNFLLAVYIDKSSLKEQLKQQDASSSQQHVLLSASQNVGLSWLDLSTGDFFTQVTTAQMLPSAIARIGAREILVDQGLQDVVGQELQLLIGHDQRLMTFFQFPKKVAPMARWEAMLEAPVLDAAAETFTREEVAAGYSLLEYIRVQLQGLNMKLQPPRRRHLDESMSIDRNSLRGLEILETARDGFGKGSLLHAVRRTSTKSGARLLRDRLTSPSTSLSIINERLDLVSIFIEDRDLHDNVIQFLKRSYDAQRLVQKFTLGRGDPDDLICLSRAIEASKEIRQVLSRKWHSEIDSQTKRSIGIMVDRIHMDGPTVLADKILAAIDEEGLLQKQRIEDDTAAEAALLAQSVTLNEGIPEDMAALPKKVKTKSSDRSNAAADEGTIADTWIMRRDASQALSELHQELEQLHTAKSELTQRLRESVGSSALTLKWTPGLGHICHVKGAKITQESLEELGVTRNVSATKSTRSFYLPAWTELGGQIDQVRAQIRQEEQVIFEHLRREVILNLVKIRRNAAVMDELDVACSFATLAQEQQLVRPILNEGTSHKIVGGRHPTVKLGLEEQGRRFVSNDCFLGGPERIWLVTGPNMAGKSTFLRQNALITILAQVGSFVPAAYAEIGLVDQIFSRIGAADDLFRDQSTFMVEMLETAAILKQATSRSFVIMDEVGRGTTPEDGTAVSFACLHHLHYHNKCRTLFATHFHILADMTHNFDTLGRYCTDVKESASGSFSFVHRLRKGVNRESHALKVAQLAGLPREAIELAKSVRQRFSNHNNSPQWDENSAPKHTAKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK95</accession>
    <name>A0A8G1VK95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_453021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511420.1">
        <property type="nucleotide sequence ID" value="XM_025660972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK95"/>
    <dbReference type="GeneID" id="37164374"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="7">
        <location>
            <begin position="32"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH53498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="320" mass="35164" checksum="5626AEE2358D4DCD" modified="2022-01-19" version="1">MTIFRSSAKASESEPQYGIKVLYDSNEAEVDIVFVHGLGGSRDATWTIDDVCWPQALLPQDLPKTRIMTFGYDSRVVSFTSALSQNGIVGNAEDLCAQLSRFRASSPERPIIFVAHSLGGLVCAQAVVAGNRSSPSDNTQIISKHVRGIVFLGTPFCGSEIANWVSRLNKVADYIFESNKANISDLKSKSDTLQHLIEEFANVLRKRDNSDDTILTTFFYEQLKTQGVMVVDRNSATIPGRGDMISIQADHKNICKFRSREDDEGYGLVLGALRKMMVEVPVKQKSSSPVFNFNNDGASIMNQAGQQTINGGMNFGSFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKD4</accession>
    <name>A0A8G1VKD4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_453102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511525.1">
        <property type="nucleotide sequence ID" value="XM_025660986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKD4"/>
    <dbReference type="GeneID" id="37164388"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="452"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="843" mass="91729" checksum="C48E364B7764595C" modified="2022-01-19" version="1">MPSMGSRKRVKPSPLGADSKSPTASDDGATSLSAGGDHAESRNRGSTASWYPAVWPAVSRASKAAPVTEVARESISAAQNLAPRLTSRSTPQLDSPKPFRNPSLQLTRKVGASSRSLPADAATTKINIASDGTTFTPEEDAKSCPAGITTQPTEEEVSRDQETVAADDADKGQLSAAPESTTDVNRDSADAGPTSTVQTGGWFSWFYAPSTTDNSAPKDPVPDPVPAPVPEPSAPEPSEESPVKPPVSKDEEQATSEDQGQTEPDRPEQDKPEETHDSSQNTVKRSWLQMWYGSSTKGPEEPASKPPDDVDKPTTQDVQTEPAPTQDHDTQGASSPATIPVKDPKPSGWSFWFKESSKGLDKEAPQESQVASASVMPDSSLKKATIEAEPEPEARAEIAKKGSVKLKNNKSSSALPDKTTLRPEAGLNDLVPGPPEAAASKQLRKVLPNQVLPRFHETFAVQEKPSLLQTIGRYFHYGKESNNRHVHMVKDTPPIKRALAIGIHGYFPAPLIRSVLGQPTGTSIRFSNMAAEAINAWADDHGYKCDIEKIALEGEGRIAERVDLLWKLLLNWMEEIRKADFILVACHSQGVPVAIMLVAKLISFGCLNAARVGICAMAGVNLGPFADFRSRWISGSAGELFEFALPYSQVSKDYESALRTCLDFGIRISYIGSIDDQLVSLESSLFAPVTHPYIYRAAFVDGRVHAPSFLSHLVGFVLKLRNLGIPDHGLIRELSSPLAGSLYSGEGHSRLYDDPSVYRLAIEFALETSTIHSANLHIKRTQPAPANPYILPFAMRGILEEEYVRRELYDETMELLRQFDDWKPTSKVLKDVKFRLEGIRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKK2</accession>
    <name>A0A8G1VKK2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_461523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513309.1">
        <property type="nucleotide sequence ID" value="XM_025661794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKK2"/>
    <dbReference type="GeneID" id="37165196"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="49"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="351" mass="39660" checksum="5F3F44DD55066162" modified="2022-01-19" version="1">MCTNLQIAFSCGCQKEMDFIQSVIHINRRAHESVRSTIAQPLKAPSTSLGQLSLLHLELIHEICLYLDIESLFRLRQVSRRAQQIVNTSRFYRETTTHALDAFCALLRTKIANQFTLTELSTALCTRDCLLCGSSFGGFLFLPTLLRCCFSCIQKDRLPRLVPYADAKWYISSKCKTASKAYRLLKSLPILRTIPGIYSMQEVSSKGRRQLVTMDDLIRVVGSKPTSDEEATWTAAKSYSNLPFMATTTLPYLDRASGRIEHGVCCTGCQVSLEEGLTKGMRFGADGLALRDKVYSHEGFIGHFRECLKAQEVWRLREMGTSVAKVSEFVRRRGYFKERDVVMSFDPANKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKS1</accession>
    <name>A0A8G1VKS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Eukaryotic translation initiation factor 4E-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_452840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511915.1">
        <property type="nucleotide sequence ID" value="XM_025660914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKS1"/>
    <dbReference type="GeneID" id="37164316"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000004">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH53993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="247" mass="27571" checksum="551CB9310B6411C1" modified="2022-01-19" version="1">MAAVAENGHAPVADENAAPVAAAVEQKEQTEKTNGDSVTVFHDPENFTVKHPLMHEWTLWFTKPPSGKGDNWNDLLKEVVTFNSVEEFWGIYNNISPTSELGLKADYHLFKKGVRPEWEDPQNKHGGKWSYSFKDKRSVPIDDLWLHAQLAAIGETLENDGDNEVMGVVVNVRKGFYRVGLWTRTVGKSIPGDKNGRTPAQGKEILENIGRRFKEVLRLKEADAVEFSGHTDSAHSGSTRAKAKYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKW6</accession>
    <name>A0A8G1VKW6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1445 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_452491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-glutamate cyclase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512035.1">
        <property type="nucleotide sequence ID" value="XM_025660835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKW6"/>
    <dbReference type="GeneID" id="37164237"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047820">
        <property type="term" value="F:D-glutamate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2040.10:FF:000001">
        <property type="entry name" value="D-glutamate cyclase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1640.10">
        <property type="entry name" value="PSTPO5379-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2040.10">
        <property type="entry name" value="PSTPO5379-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009906">
        <property type="entry name" value="D-Glu_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038021">
        <property type="entry name" value="Putative_hydro-lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022:SF10">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07286">
        <property type="entry name" value="D-Glu_cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160920">
        <property type="entry name" value="PSTPO5379-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH54113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="301" mass="33475" checksum="32B99F43297CA426" modified="2022-01-19" version="1">MTVTTQTPETLSSQKTRLLARQNTITNTAGYSGTNLQANLLILPEKYSQDFHNLCLRNPVACPLLGISSIPGNPHKISPTPCIRNSDFDIRTDCPAYRVYKHGKCIAANKRDLLDLWSTNDDEQQSSENYTAFLLGCSYSFEAALCNATPPLTPRHQVTNILVPMYRTSLPLSPAGIFTNTTCTVSMRPYHESEVERVRDITRPYLATHGEPIAWGWDAVKRLGIRDIHDPDFGDKVEFGEGEVPVFWACGVTPQMAVEAAGEKIDGLVFAHEPGHMLVTDWVVEDLERLKEGIAAFRAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLH5</accession>
    <name>A0A8G1VLH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_422609</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514657.1">
        <property type="nucleotide sequence ID" value="XM_025657975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLH5"/>
    <dbReference type="GeneID" id="37161377"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051563">
        <property type="entry name" value="Glycosyl_Hydrolase_51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776:SF0">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034400674" description="non-reducing end alpha-L-arabinofuranosidase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="10">
        <location>
            <begin position="432"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH56735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="617" mass="66376" checksum="07E54FE471E6547F" modified="2022-01-19" version="1">MYSSTLVSLAAALLAGQTLAIELTVSKSGGNASSPLLYGVMFEDINNSGDGGIHGQVLRNNGFQGDDPGLTAYSAVGNVTISQDTANPLSSAITSTLKVAVPSGATGYVGFANEGYEGVPVLGTDYDNYFYMKGDYSGTVNLRLVGNSSGIIYADHNITVDSTSTNFTYYETSFSSSVSADAHNVWQLRFDASKVAGSSLNFGLVQLYNGLRNDVASFLADIKPSFLRFPGGNNLEGASPSDRWKWNETIGPVVDRPGREGDWSYPNTDALGLDEYLQWCEDMDMEPLLAVWSGLSLGGGIVSGSALDPYVDDILNELEYVLGSADTTYGALRAKNGRTEPWDVKYLEVGNEDNLNSGCGTYANRFTLIYDAVHAAYPNLTIVASTTDTSCLPSTIPDGVITDIHHYLTPDEFIDLFDEWDNWSRDWPILVGEYASTTGNDGSTTYWSYMQGSCSEAVYMIGMERNSDIVKMASFAPLLEHFDMAEWSPDLFGLDSSPDSITGSTSYYVQKMFSTNRGSTVLPVNTTADFDPLYWVASVSDEGTYYVKLANYGSSSQNVTVNIEGTTSGQLQLLSGGETVSNYPHDVSIKTQTSTVSGSGSFTVDMPAWAVAVLAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLH8</accession>
    <name>A0A8G1VLH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_306859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515528.1">
        <property type="nucleotide sequence ID" value="XM_025655383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLH8"/>
    <dbReference type="GeneID" id="37158785"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="52" mass="6150" checksum="C44E6A871BCD980C" modified="2022-01-19" version="1">MVPISDANLSHRTSIQHINWDLIIYAVVSYIHVRFLFVCFIQQARCLFIPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLH9</accession>
    <name>A0A8G1VLH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_452155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512650.1">
        <property type="nucleotide sequence ID" value="XM_025660759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLH9"/>
    <dbReference type="GeneID" id="37164161"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044986">
        <property type="entry name" value="KIF15/KIN-12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37739:SF16">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37739">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIN-12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="877"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="575"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="914"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="957"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="978"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH54728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1043" mass="116099" checksum="2998A23DD7B269A0" modified="2022-01-19" version="1">MPDQQSIRLSREVERLVTAPYAPSFQDLYSLTQSTTSQSIRLWASHKPCQIGALVEVLVDGLSRSRFALPLLETFVSAPAIRDALLERHPCLLDQFLEGAIGDDKAEYALVCTAILSSPLPPEFMIPARLTQFMEKMIRTMGEDPRAENILPLNQISNGIKRSPRLLEEIPSQVMASLQVELTKTLRNLSDHMGNLLCLATFARMASLEDPGTEKGCVRFVPSWLQSVNHFFGPKRGLKTLDLVVLRVILACSDSCSDLTVDKAAESIRLAIEICDRVEPEQRENWVKANGSKIAKLREKITRSGIDSGVQMLGATFLASLLPVAALSTDIARVAVDGLKSRDSKFVLGVLTSEYIPRLVGASVACLGVTAIRSLLEYIVSSLDTTSSPSLTHILVAKSLVTGLHSASLNSAIFAEPLEQCQQVLWKITESFPRNYALSSCHGSQECGAARSQLENELIYDILSFYLHALLSQTTTQDTIAGNATLQMFLAQNKQLLHGQKCSFSEAESSRAAKTYTTLNVREGVSAPSSRSDWRSSMSETLMLNARVSNDSLMRKMEEVCYDLEQRCDDVEAPLRAMEQERNAISAEAQQLREQNGALELQVQQASDTMGGLRLEISRLETHAEAASIRAEELSATLDAARRDLEDQRREFQDSMASEVEKARTKELDLVASITERDDQLESLQDEMIAQRAENTSLQNALDEASKEKSSLIKTNDSLNQNMAGLEEKLRQSELLLVQKDEYRGQILSEKAETERGMETLRIQLEEERMKSHQLASTLEKTERGLQVEQGIVRDYEAQLSAASTKYETQKEEIFSLRMAMQAAASDATKELQAKDKRIHHLEKKVQQLRNERAAKAREFSEAQQHIGRLMDVMGIRADTDGTRPPSKQTRKSSARPSSTTMTQQTQPAEDELQTQPENSQVEPFENNLSSPPCRSPKRTMDNAFPPADPSSQQIRGGRKSRNVTPQHRRTPLEDADLNSQPCAQRSPASQRSECGTSDQVRTRASLEENQLQHIDLDMDLEFSKDFLFTSTSLSTANDPTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLW0</accession>
    <name>A0A8G1VLW0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_399253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514779.1">
        <property type="nucleotide sequence ID" value="XM_025657089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLW0"/>
    <dbReference type="GeneID" id="37160491"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH56857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="202" mass="22941" checksum="CFE0C58033FB7620" modified="2022-01-19" version="1">MEPRKTPPEYFLEIFADTTNVRDVLKGILNTIFFHRYFPSIRPITFDVLDFTLPAINDVDLETLIDSRVSSLVRQHSSAASAPDGGGGGGVRARMAVEFYEKRRRRPGIWFGGLSGKGEEEVCWEVWNLDVTIATPRTESERAKVRKAMENMLQKAVLKILAVVSRDKEHIPPITTSDSNPFPYRVVLNPRSDGWQNRFGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM11</accession>
    <name>A0A8G1VM11_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_377202</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513175.1">
        <property type="nucleotide sequence ID" value="XM_025656253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VM11"/>
    <dbReference type="GeneID" id="37159655"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="448"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH55253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="799" mass="89264" checksum="982AB4EFDD8DB725" modified="2022-01-19" version="1">MSNFLVTGSSRGLGLELVRQLSARACLEGGLVIATARKCSPKLTELIAQSNGCIVFVALDISEESIIAESAEQVRSALNENSLDMLINCAGVHSETHGKLAIVRSLPGIQDQQSSTERLNGPICAWLQSDMGGKHADLTVPQGAEAVLNIAMSADRMDNGRFKNIHVPGWEAYKGQDMPVWNANAGGADGQLRRETKGLLSFIVIYTYEVTDNERQYPKAPRKHKHSQPNDQVLDSRERSLTTPTNSTPSVEGPNYHAIQAKNIIQLELNDSRHVNRGRQSILRSALQLVSQIAESEPQHSDEIMEEFQPNDPALSIPDAPPRELLFMLLQGPPESMCIQWPDHISRKTYEEMATALLRSEPRLQGQRLHQYSICIYVKAIFHIYQVSRTVRSPLLKSQLSQSRSTYIAATIWSIENLSILKQPDLSTIQALLSSALLMQHLGRLNQCWVLTSYAARQIASLNYHKIRRVPARSDSELEVYSAVYWCYYLDRTLSSLLSRPPSLPDLDVSPTDLIVLDPCSPYDTLLRVLLDLAQVQGKLHAVSSDTRNTSNSQALETCQLLESRMQSILREMPSVRVSGPHINRASLPKMVQHDWVAVDFCYYAIFVEIDRTRLKNSFSPVIHRECLVHARQSLGAFHFIQQHAEEMPGFEEPYPSFLTCAFFVVICNIIGTLDHDDFKLLQQITQSLSQFKQDPHLGKLLNLLQSLEDLCEPLFQEGASGPENISSNLRASAPNQVMEPVTMDGIPPSASFDSNFGLSDEPIPNSELDASADWLMWQLFNSQIPAGWLSSSMDPFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMI1</accession>
    <name>A0A8G1VMI1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_65251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513640.1">
        <property type="nucleotide sequence ID" value="XM_025665560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMI1"/>
    <dbReference type="GeneID" id="37168962"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="183" mass="18122" checksum="00D78B147F209B43" modified="2022-01-19" version="1">MPKKGGKNKNKGKKSGGAAAAAKKAADAPNNVVPANEVEETVAKSDSELEAVAAEAGVTDTTAPEAVVPETVTKDESEVEAVAAGADTGVTSAPETTIPETVAKSESEAVAAETAPAVTAAPVATVTDTAAPVPAPAPPVNFTEEASNAVNTAFPKINDGIVEDAAQQTKTAQAETVEEGTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMS8</accession>
    <name>A0A8G1VMS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_369513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517086.1">
        <property type="nucleotide sequence ID" value="XM_025655926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMS8"/>
    <dbReference type="GeneID" id="37159328"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="118"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="367" mass="41298" checksum="1C9DF2EB26D91132" modified="2022-01-19" version="1">MPALNDEKTLRELRPRVLLQPLHNSIPSELLPRFDPVYVEHYNKYNAGRLHTHEVPIEEFRKNPAKYAIVYGRAQGPDIFRITEQTCPVEGGEITIRIFEPAPKLDEHGKAKKRAAYVNFHGGGWVFGDLSVDHDFCKTLVDGLDGQLVAFDVDYRLAPEHKYPIPVDDCWAAFNWIRSQKAEEFNVDPDRMAVGGCSAGGHLSAVVAHLCRNAGIPLRLQVLNVPVCDLHSGYTPDGDFDRENCPYESYREMEFTAALPVARMAYFHRHFLGVPRPARSEEDWKISPMFAPDFSGLAPALVFTAEMDPLRDEGEGYAAKLKAAGCRVEMMRMAGAPHTIAMLNGIMESGRIYIEKVIEAMKRELTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMT0</accession>
    <name>A0A8G1VMT0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_511542</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516953.1">
        <property type="nucleotide sequence ID" value="XM_025664603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMT0"/>
    <dbReference type="GeneID" id="37168005"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF75">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="49"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH59031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="490" mass="53883" checksum="B6CE94065E0319A3" modified="2022-01-19" version="1">MSQVFKPIDDPGSEHIEGVDPDCMDHTLQRVQVSPERQRSIVRKFDRHLLPLLSVLYILSYLDRGNIGNAKIAGLQESLNLDDSDWSWVLNSFYLCYTVFEWTNLLWRLFPAHYYVAVLCICWGAAAMCSGAVHNLGELIVCRCLLGVFEASFGAGAPYFLSLFYQRHELGLRVSVLLGMSPIANCFASALAYGITQIRNGLEPWQYLFLIEGAPTVIISVVVFFFLPDSPGSARFLDEQQQADAVGRLTTQDRTAKDRVHWKQIWSGLLDYKNYVHMIIHFCCNYSFAGLSNFLPTLIEDMGYVSVHAQGLTAPPYLGSFICCLAAAFLSDRLGNRGLVVVGFSTIGLVGYLMLACVHDASADGVRYAGIWLATCGVFPSLAINITWLLNNQGGDSKRGAGMAVLAIFGQCSSFVSSSLFPATDAPNYTRGCAAGAGLTGLVVVLGAVLHCKLRLENARRNRVHGRVSEEHAIDVTEAGDDDPNFRYIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNB0</accession>
    <name>A0A8G1VNB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_393442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517626.1">
        <property type="nucleotide sequence ID" value="XM_025656883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNB0"/>
    <dbReference type="GeneID" id="37160285"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="345" mass="38939" checksum="8E6F590F492A077C" modified="2022-01-19" version="1">MESHNSPRRLLLVSVPRTASNLLLKILNIPGQPNAFAADRGGYFFYNAFHAVAKDGRLTQAPSEWTDEAKHEVQSTFQECFDHLEETCALAERENKTMFAKEHSFWLSNPMAFMQAIHGPEKGPYDFSTFHVNVPSTYGTTRTFSTNNKTVLPDEYLRTWTMAFIIRHPAIVFPSFCRAMNKISDMGVMDTKILPGTLLTNMTLHWTRSLFDWSLEQTGSTPLLLDAYDVVHNPDAVTKFCRLAGLDPSKLQFQWERGVHADSVARPNGASQGVFDWDTGKSVMLSTLNESSGVMKSKEPAVVDIPTEVKKWQLEFGEDMAQLLEKAVSDAMPDYEYLRAKRVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNN2</accession>
    <name>A0A8G1VNN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chymotrypsin inhibitor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_281413</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516699.1">
        <property type="nucleotide sequence ID" value="XM_025655204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNN2"/>
    <dbReference type="GeneID" id="37158606"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034865152" evidence="3">
        <location>
            <begin position="22"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="25"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH58777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="78" mass="8096" checksum="3C1BAC534CA0235C" modified="2022-01-19" version="1">MKTFSIVFALGLLGTPLLTAAAPNCGSNEVFHTCGTSCVATCSEPNPASCTLACIPGCECEEGYIRNDAYKCVLPTDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNP4</accession>
    <name>A0A8G1VNP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 10">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_436911</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 10"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517913.1">
        <property type="nucleotide sequence ID" value="XM_025658593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNP4"/>
    <dbReference type="GeneID" id="37161995"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="11">
        <location>
            <begin position="338"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH59991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="421" mass="47208" checksum="DEC57E80E7D94A2E" modified="2022-01-19" version="1">MAATTSPQRWKHLYSVLTKSGPFSDEDWVPGPETISALESSKILVIGAGGLGCEILKNLALSGFKDIHVIDMDTIDISNLNRQFLFRQSDIGKPKAEVAAAFVERRVKGVKITPYVGKIQDKDEDYYMQFKIIVCGLDSIEARRWINSTLVGMVDFEDPESLKPLIDGGTEGFKGQARVILPTLSSCIECQLDMHAPRPAVPLCTIATIPRQPQHCIEWAHQIAWQEQRKDDAFDSDDMEHIGWVYNAALERAKQFNISGVTFQMTQGVVKNIIPAIASTNAVIAAATTSEALKIATSCNPYLENYMMYAGEEGVYTYTFEAEKKPDCPVCGNLARKLTVNPNMTLEEFIETLGERPEAQLKKPSMRTEEKTLYQRFPPQLEEQTRANLKLKLKDLIEDGQEIAVSDPAYIIDFRFRLAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPH5</accession>
    <name>A0A8G1VPH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GPI anchored protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_446153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518916.1">
        <property type="nucleotide sequence ID" value="XM_025659440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPH5"/>
    <dbReference type="GeneID" id="37162842"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF32">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034787852" evidence="1">
        <location>
            <begin position="20"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="364" mass="39854" checksum="D338CAD0F86FACC1" modified="2022-01-19" version="1">MKLSSIAPLAIALTATAQASYINYTTVTGYFLQDEASTDASTFDYTTTNFGLINRTYPSDNPNNDNNLLTQWERFHHHITTLNHLSPPTISYKVLFLGRHGEGYHNAAESYYGTPAWNCYYSLLTGNSTTTWSDADLTPSGIQQAQIAHSFWSHQIASQRIHTPDTYFVSPLLRALRTANITFSDLPLQPSSSPFTPVIKEFFRESVTLHTCDHRHNATYIHSLFPEWTFEKGFSEEDGMWDGVRAESNAAQDVRSKVALDEVFAGDDDDDGVGMFVSVTSHSGEIASLLRVMGHREFGLRTGAVLPVLVRGEIVGDALEPTGTGTRWETSAHCTAPPVTSVSSGCVCASSAVPVTTPLVTFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPR6</accession>
    <name>A0A8G1VPR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_368179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517899.1">
        <property type="nucleotide sequence ID" value="XM_025655855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPR6"/>
    <dbReference type="GeneID" id="37159257"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="185" mass="19638" checksum="8BDE2854510637AE" modified="2022-01-19" version="1">MNHNLTSLPTPASNLTLQHVALGRGIQNYTCPSPQNSTSKPTSVGALATLFDVSCIASADEELLHHLPALVQGIPLETLDFLATMISLAGTGAGILGEHYFSGSGQPSFDLRFSGDDDWAMMKKVASANAPKSVDVPWLKLDGIDGVGIKEVYRVYTAGGVSPATCAGHEGEFEVDYAAEYWFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQD4</accession>
    <name>A0A8G1VQD4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="11">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_447342</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="11"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518677.1">
        <property type="nucleotide sequence ID" value="XM_025659703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQD4"/>
    <dbReference type="GeneID" id="37163105"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="98"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="183"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="397"/>
            <end position="402"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH60755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="498" mass="55549" checksum="8E7C51BBB74A56BA" modified="2022-01-19" version="1">MSSVRFSSALARRSFAVASPPLSAPLSSSARRFLSSSSSSISSSSSSVSTRSPRSLTSASSLLSSRTASARWTGLSSLNLTQSRTMATEISKIKVKNPVVELDGDEMTRIIWQEIREKLILPYLDIDLKYYDLGLEYRDQTDDQVTVEAAEAIKKYGVGVKCATITPDEARVEEFKLKKMWLSPNGTIRNILGGTVFREPIIIPAIPRLVPGWNKPIIIGRHAFGDQYRATDRVIPGPGKLELVYTPVNGEPETVKVYDFQGGGIAQTQYNTDESIRGFAHASFQMALLKGLPLYMSTKNTILKRYDGRFKDIFQEIYESTYQKDFEAKNLWYEHRLIDDMVAQMIKSEGGFVMALKNYDGDVQSDIVAQGFGSLGLMTSTLVTPTGEAFESEAAHGTVTRHYREHQKGRETSTNPIASIFAWTRGLIQRGKLDETPDVVTFAEELERACIEVVNDEGIMTKDLALACGRKEREAWVTTREYMAAVERRLKANLKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR36</accession>
    <name>A0A8G1VR36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfide quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_444925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519412.1">
        <property type="nucleotide sequence ID" value="XM_025659140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR36"/>
    <dbReference type="GeneID" id="37162542"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000203">
        <property type="entry name" value="Related to sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="38"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="448" mass="48524" checksum="A3599F2BF14A45D2" modified="2022-01-19" version="1">MFCRNVTSAASTAGRAATAAQRTFATAAPVSPVARSHKVVVVGGGTAGLAISHQLLRSGKFSQDDIAVIDPSMWHHYQPGWTLVGGGVKTKEDLRRPMHDLIDPKFKFYNQSVGTFLPENNSITLGNGDKVNYEHLVVAPGININYGSVKGLPEALANPDSLVSSIYGYDTCDKVFSTVQKLQKGNAIFTQPAGVIKCAGAPQKILWMALDYWKRAGLYNPSSPASSPINISFATGMPSMFAVAKYGAALEALRKERGVEGLFQHDLVAIDGNKATFARPDGQEQVTRQFDLLHVVPKMGPHAFVKDSALANEAGYVDVDAGTTRHTKYANVWSAGDASSLPTSKTAAAITSEAPVLVHNLLRSMEGKPTDAVYDGYASCPLVTEYGKVLLAEFKYGGEPKETFGNWFGIDQAVPRRSFYHLKKHFFPWVYYQSLVKGTWAGPKGWTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRL7</accession>
    <name>A0A8G1VRL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Developmental regulatory protein wetA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_123066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the wetA family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519924.1">
        <property type="nucleotide sequence ID" value="XM_025653928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRL7"/>
    <dbReference type="GeneID" id="37157330"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040112">
        <property type="entry name" value="WetA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934:SF25">
        <property type="entry name" value="DEVELOPMENTAL REGULATORY PROTEIN WETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934">
        <property type="entry name" value="PROTEIN ESC1/WETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0183">Conidiation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="237"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="276"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH62002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="563" mass="60460" checksum="D6F92A29F9F53299" modified="2022-01-19" version="1">MFAQQFDHSLNDLDLFNQYVNMDNSSVDGNKDVSFPGDLDQIFQLESLSSDCGEHSPAISTSTAQPHQQTAQNWSKDFWCLSQNADSSTSQGQNFSLQDTVHPSAVSELGVNFEAPPTACAPETRPSPSTPPATPSRKTTKSAVTTPKVIRRHREPNDRRGPLHKQSFSPGITRSSQPQRNRMAYQEAWAQRFNNFSFRSSDERLPLSPPPSDILVQQENMAADNSAAHLNRTESLPKASAEMPPQYDTGIFNQSPAISMPSPSTAALAGQPPRYLSQSSGSGLPTSSPPSADDIFSSPHSSGPQSMSSWHSDSLGSSGIPYSTPDLSGQDGQAWWSPMASRVPQRQPSYQQMVASPAAQRPIQNSASQSDMLQGGLMIQLDPSSYDLSNTHSSFPSAGLPSAPNGHESRAYMQPTAAPVDSSSFVTPQIPPSHSRSPSLSPGSGSPKSGSMMHNGHRRSFQRQSMNRKLSSNSMSAPKPVKAPHSSSGSPKGGNKAVTVSFVNFTQNDSKRILTGVAPSGSSKTKARREQEARARRREISEAALQAVRSAGGDVEALEAILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRZ6</accession>
    <name>A0A8G1VRZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin cytoskeleton-regulatory complex protein PAN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Actin cytoskeleton-regulatory complex protein pan1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BO85DRAFT_445841</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520342.1">
        <property type="nucleotide sequence ID" value="XM_025659362.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37162764"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000349">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein PAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013182">
        <property type="entry name" value="DUF1720"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF173">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN PAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08226">
        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="20">
        <location>
            <begin position="173"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="20">
        <location>
            <begin position="462"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="495"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="22">
        <location>
            <begin position="1422"/>
            <end position="1439"/>
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    </feature>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
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    <feature type="region of interest" description="Disordered" evidence="19">
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            <begin position="617"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
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            <begin position="786"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="892"/>
            <end position="1093"/>
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    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1108"/>
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    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="711"/>
            <end position="759"/>
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    </feature>
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        <location>
            <begin position="29"/>
            <end position="51"/>
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            <begin position="57"/>
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            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="20">
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    <sequence length="1455" mass="157300" checksum="FE6457617378C506" modified="2022-01-19" version="1">MYSSSNTFLGGANSARPGQPFMQQSPYSQQFAPGQHQQQQPPQQGGFAPQPTGYGPQMSSFGASQLQPQATGFPAGQLQPQFTGFPGAVPQSQPTGFQPPVQQPQITGYPAQSQPPQFQVPASTGLPVRQAPRTSSEIADSFQDVAGMAPPPPPKASASKIPNIRLSFITAQDQAKFEQLFKSAVGDNQTMSGDKAKELLLRSKLNGSDLSKIWVLSDSTKSGQLFFPEFALAMYLCNLRITGRELPSALPEKIRNEVSSMVDIISFQVPDTQPEPAARTNVPNFDVPLLENKSAPPAPQQPQPQQPSNAQLLTQLTAQPTGFPQPTGFQQSQSPFPGQNSALAPQATGFPGQSQQLQPQATGFMTNPQPTGYSGPRPPMPPMPTGFGSNLSPAQTGGVSALTAQPTGIPGQWGFVNAPATGLPNIEALKQQLMPQPGREGGFTTVGLSGNAHIPWAITKEEKKIYDDLFRAWDGFRKGFIGGDTAIEIMGQSGLNRSDLERIWTLADPNNRGRLNMDEFAVAMHLIYRKLNGYPVPNRLPPELVPPSTRNLNDSIGTIKSLLSQDAESRKASGAFLQPQKTGVSYLKEHSFRGGAVSPGVGRKDATLFKNNDEAAAGYRSSARRRVGNNGRTPSPAASQASEEELSVDQLKKKIREAQIMLDAVDFQDENQAEEDDALDRRDRREAESLMDRIRRVQDDIDTHPDASFRNLDTGAERRSLRRQLQAYEDQVPQVASEVRRVEREIAEVRLELFRLKDAKEHPNSASSIVGTGPGGTVTEADRIKARARARMQARAAELAGRPVPASQDDDGAATRRLEAENATVKAERERNETMTRDVEESVREFARSLEDSLKDGGESSTREHERRRWEDALGVEDVVRDFIYDLKRSSRTAHVRKEEQQRAADTQSQRSRYDESPLGGAAASQNSPTPTGSVVSAGSTHEDRVAAARERAQKRIAERMAAAGLKPHSDAGETLLQRQEREKKEREERLRRAEEEDAKREQERQRRLAEEQGGPTAQSAKPAGKKPPPAPPSRKGRTDSAGQAEAKKAREEAAKIEQSTREQAIREEQQAQEEETARLETAAREREAEFLKEKEAQEARLAALQEQVRQGKIKKQEEKRRKEEAARAAKEQEARLATQRAELEMAKERERQLQLELEGLDESSSDEEGPINITPQDSTPTQSQVLPAADTAVPTPAPAPSVPAPELEVVTSPAESASSHAAPTSLSPEAESKNPYFKRISPSDSQVPPPPPAPQPAAPKAESQSTNPFHRLAQQQESSKPAFTAPGPLERKSRVRPEADDDWSAAGSDFDDSSDDDDERPGGGSAKQLASILFGTMAPPRPLSAMDDKTPSKSSTPVQDSPATPAPPTEAAEPPAAPAAVPPPPPPPPAPAPAPSMAPPVPPPGVPPPPAPPAAPMGGSGRGALLASIQAGTGLRKVQTNDRSISSSAGRVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VS06</accession>
    <name>A0A8G1VS06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="8">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_390047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="8"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520372.1">
        <property type="nucleotide sequence ID" value="XM_025656756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VS06"/>
    <dbReference type="GeneID" id="37160158"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000004">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000012">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH62450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="304" mass="33428" checksum="B38F7C8144D26E17" modified="2022-01-19" version="1">MRTMAPKFYQHDGKPIDLDEIHDYLISLAFRAGDIINSALPTDDSTGSKMNSADIVTRYDKAVETMISSALMEKYPSYQFHGEETYDPAHPLTDAPTFVVDPIDGTVNFVHGFPCSCISLGFAVRRVPIVGVVFNPLTRTLYSAIQGRGSYLNRTTKLPLKGDDIGPLKGLENSLVGIEWGSERTGANWETKVRTFEKLGRAKEDGGAMVRSMRSMGSAALNLCAVAAGTLDIYWEGGCWAWDVCAGWVILTEAGGVMIDGNPGTWEATLDGRRYLAVRACSDENSRLELIKEFWGQIQGSFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSC4</accession>
    <name>A0A8G1VSC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fructosyl amine:oxygen oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_410058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520704.1">
        <property type="nucleotide sequence ID" value="XM_025657459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSC4"/>
    <dbReference type="SMR" id="A0A8G1VSC4"/>
    <dbReference type="GeneID" id="37160861"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF24">
        <property type="entry name" value="HYPOTHETICAL FRUCTOSYL AMINE:OXYGEN OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH62782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="443" mass="49148" checksum="379DD0D809748B99" modified="2022-01-19" version="1">MASSTITHDSTILVVGAGVWGCSTALHLARRGYKHVTVLDPYTIPSAIAAGNDINKIMEHKEPKAGEETPRSIAFATCTRAALKAWRTDPVFKQYFHETGVIVSGHTPALIEHIRKDEIECSDADFVELKTAEDFQKTMPPGVLTGEFPGWKGWLNKSGAGWIHAKKAMISAYTEAKRLGVNFITGSPQGNVVSLVYENGDVVGAKTSDGVIHRADRTILAAGAGSDRLLDFKKQLRPTAWTLSHIQMTPEEAKLYKNLPVLFNIAKGFFMEPDEDKHELKICDEHPGYCNFIPDPARSGEIRSIPFAKHQIPLEAEARVKDFLRDTMPHLADRPLVFARICWDADTVDRAFLIDKHPDYPSLLVAVGASGNGAMQMPTIGGFIVDALEGHLQDELKHVVRWRPEMAVDRDWKSTQNRFGGPDAVMDFQKVGENEWTKIKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VTZ4</accession>
    <name>A0A8G1VTZ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-1,2-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_131952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520255.1">
        <property type="nucleotide sequence ID" value="XM_025653996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VTZ4"/>
    <dbReference type="GeneID" id="37157398"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000005">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000002">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF23">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034243225" evidence="2">
        <location>
            <begin position="21"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="4">
        <location>
            <begin position="30"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="3">
        <location>
            <begin position="281"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH62333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="760" mass="84126" checksum="0D74D51A4637D776" modified="2022-01-19" version="1">MRPLQPYLLHILPLLPLTHSTNTTTDILTHINPLIGTTNGGNVFAGATLPYGMAKAVADVDGQNTAGFSPDNSNITGFSALHDSGTGGNPSLGNFPLFPQYCVDDLLDNCPFPKSARAVHYQNDSVVARPGYFALTMTNGIHAEMTTTQHAALFRFDFPDTAEQKLSPMVLLDLTDLWESRQNASISVDERTGGNRANGTFLPSFGAGQYASYVCVDFAGAEVKDTGVWVNDAGGVERKELFVTRGFNNFYLQAGGFVRFERPDNGTVSVRVGVSYVSTEKACENARVEIPSPLEDFDAIRAAAEDAWREKLSPVEMTPGNTSASTALQTMFWTGIYRTMLDPQDLTGENPLWESDEPYFDSFYCIWDAFRAQHPLLTIIDPTTQSRIVRSLLDTYRHEGWLPDCRMSLCKGWTQGGSNADVVLADAFVKNLTGIDWDLAYEAMVNDAENEPLEWSYQGRGGLQSWKTLNYIPYHDFDYLGFGTNSRSISRTLEYAYNDFCVATVARGLNKTDDYLKYLARSTNWKNLFKPDQRSFFPNGTDTGFVGFFQPKYRNGTWAHQDPMDCSPLATGPTWCSLTSNPSETFESSIWEYQFYVPHDLPTLITNYLSGPTSFISRLSAFHSTALADYSNEPVFLTVYQYHYASRPALSSRLIHSLIPTVFNTSRSGIPGNDDSGAMAAFTVFGLMGLFPNPGQNVYLISAPFVEEVYTRCWIGHEFFVKGGVLELELGEADGEDEEESEWGTGVGEGPPSWGGGMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QPN6</accession>
    <name>A0A8G1QPN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_385305</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825091">
        <property type="protein sequence ID" value="RAH51926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509848.1">
        <property type="nucleotide sequence ID" value="XM_025656589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QPN6"/>
    <dbReference type="GeneID" id="37159991"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH51926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="491" mass="55180" checksum="422229D59CDCF2E1" modified="2022-01-19" version="1">MQLLSLFFNAFAAGILLLLGTGGYVIYQCFLSPLARIPGPFLAKLTNWHRAYLTYEGQAHRKYLALHRKYGAVVRTGPNVLSVADPTAFREIYKAGGKFAKSASYSVPKEIHAFDLFRQRNEKIHGEQRKLVARAYSMDSMVHLEPNVSSLLTTMVQKLDTLSGVVDLGVFLQLFAFDVIGAVSFSRPFGYVTAGNDDGVFSRLKQSLRSMSWLMNVPWFYDLHQVLKPYIGNWLAANDRNGYFYQFAAQEIVSRKDRGGDDRDIVNQLFAIQKTKPQFSDTDMAYMLTANVFAGSDTTATSLNAIFYLLLKNPTVYQRLMQELEEKRAAGELSDLVTFQQAESCPYLQAVMYEALRLYPAAGLQLNRDVPEGGMKVGKYYVPEGTVVGSSAWVIHRLPEIWGPDFEEFRPERWLEGDVGNLKRFYFSFGGGSRTCVGRSDWLEMSKLVPTLLMRYNIQLAPGAKVTDESGGLIFIKGLNVLLSPRQRAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRW9</accession>
    <name>A0A8G1QRW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flavin-binding monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_481832</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825084">
        <property type="protein sequence ID" value="RAH52457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510379.1">
        <property type="nucleotide sequence ID" value="XM_025663078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRW9"/>
    <dbReference type="GeneID" id="37166480"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF4">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="563" mass="63836" checksum="1C50BAAEFFC8EEF3" modified="2022-01-19" version="1">MPSNYAHHVGNHDYTRATVVIIGAGVSGICMAIDLLRRTPVRKFVILEQGSAVGGTWANNLYPGCACDVWSALYSYSFEQRPDWTAEYPAQEEFLEYLTDIAQKHGLYQYIRFNSTVQEARWDDQQRQWKVQVALNGAKASEFHEEYELTTDFLVSAVGQLNVPSYPSIPGLDDFTGKLIHSARWDWTYDFSGKRIAVIGNGASAIQIVPEIAKTASHITIYQRSPKWVVPRFNKPVGAFQQFLLSYVPPVRWCKRALQMRFREWSYNVLVTPGTVPAREAEEDAKKWMKTQLPDKPELWDTLTPNYAIGCKRILISDDFYSALNSSHVDLNPKPIQRITATGVQTEGDEQEYDLIVLATGFRASEFLHPIRVYGAGGRSLEDIWKGGPKAYYGMTVEDVPNFGMLYGPNTNLGHNSIILMIEAQSRYITTLIRAVADAKKKDQTLVIQPRPDVLREYNDRVQKQLAETSFADPNCQSWYKTDKGLITNNWPLKVVEYQKEVSQVRWTDFLIKGDGAATVEKKKATYVGRVREEVLISNVTLFLGVALAAGGVYWRATRGWKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS31</accession>
    <name>A0A8G1QS31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_431302</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510506.1">
        <property type="nucleotide sequence ID" value="XM_025658331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QS31"/>
    <dbReference type="GeneID" id="37161733"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF16">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH52584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="297" mass="31865" checksum="2E280C1F56760EE3" modified="2022-01-19" version="1">MASAMGKEGVFQPPQAAQSQNTPGLEKKMAPASEATKLESSGTFVEYVGSGKLKDKKALITGGDSGIGRSVAVLMAREGADVTIVYLPEEEEDAQDTKKMVEAEGKSCHLFSGDLRSRETCRKAVEEHMNTYKKLNILVNNASKQIMCKDFAQIDLDNVTSTFESNIIQMFAITKFALPHLSRGDSIINTTSTVAFRGTSGMVDYSATKGAIVSFTRSLAAQLKTKGIRVNAVAPGPVYTPIQVDTRAPEQMENFGAESSIGRPGQPSEVATSFIFLASADAALFYGQVLHCYPLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS53</accession>
    <name>A0A8G1QS53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Involucrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_385453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825092">
        <property type="protein sequence ID" value="RAH51837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509759.1">
        <property type="nucleotide sequence ID" value="XM_025656595.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37159997"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053268">
        <property type="entry name" value="Woronin_anchor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40641:SF2">
        <property type="entry name" value="INVOLUCRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40641">
        <property type="entry name" value="INVOLUCRIN REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_2G08060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="930"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1184"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1306"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1446"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
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        <location>
            <begin position="75"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
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            <begin position="308"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="652"/>
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        </location>
    </feature>
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        <location>
            <begin position="673"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="691"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="779"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
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            <begin position="893"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="992"/>
            <end position="1008"/>
        </location>
    </feature>
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    </feature>
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            <begin position="1097"/>
            <end position="1115"/>
        </location>
    </feature>
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        <location>
            <begin position="1122"/>
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        </location>
    </feature>
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        <location>
            <begin position="1184"/>
            <end position="1196"/>
        </location>
    </feature>
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        <location>
            <begin position="1197"/>
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        </location>
    </feature>
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        <location>
            <begin position="1218"/>
            <end position="1230"/>
        </location>
    </feature>
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        <location>
            <begin position="1234"/>
            <end position="1250"/>
        </location>
    </feature>
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        <location>
            <begin position="1347"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1368"/>
            <end position="1399"/>
        </location>
    </feature>
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        <location>
            <begin position="1411"/>
            <end position="1422"/>
        </location>
    </feature>
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        <location>
            <begin position="1492"/>
            <end position="1502"/>
        </location>
    </feature>
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        <location>
            <begin position="1588"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1654"/>
            <end position="1664"/>
        </location>
    </feature>
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        <location>
            <begin position="1682"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1719"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1746"/>
            <end position="1783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH51837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1796" mass="197015" checksum="9240C2F476B42CD4" modified="2022-01-19" version="1">MFKALLGGGRSSSDVRSSSSSKSSSRRRTDSKSSTVSRKSSRGDDRDRGLGDLSNYRSSSSRSKRYAPSVAGESVASSYATADQGTPIEPDRVMIERAPRRQDSNDTTDRRDRYRDNGDGEGKSSRRRERARSPSRERERDGDRRERQRTQSGDLYASPVTTGMPPSPGDFATASPHSYPPVTEAMPTTSMPSPPHATAFYDPHVTQQFPGQFPAYVAEPYQPPNPAGEAADYYGDQGQSVQDQPGVRPKPPLVAPSDQAHLMTASPTANPPPEPSELGQIGAAAAYFMDDAELGMEQPVKPPSASAPKPPKPSRPPRPSVQTAGISSPPAVATATTMSGAEVVDSPGHTISESPATYVPPTASSPPKPPHSHGAGAAVGAAAAGAAAGYMMSHHHQSANVDHSSQYTMQNFEEVLPAYPETPAFPPQQNMLPFAAGPAAAAAAGYAASPLHPDHAAVYHGAPFQSGGLAFQQRQQGPLDKFINFWKDPEGVGMFEDYTESIGVCKYCFEPGTTSQDAPRKHNHKPRRRSADRYSNGSRVDKASRYSSSEDEGRRRNRSSRNSWLPGLLGGYAVKSIFSSKEFDESYSIRTGEVASSRHSIHESEGASTAGRRSQTSRGVYRRTHRSRSREHTDHSSYHSDSKLSRYEGSRLRSRSRSRSSSRSQRHAALRNAALGVAVGTAAVSEYESRHRSRSRSTSSRGRKPRKTSSSDESFVDISRPARKTVGSGFSSFFTASSENRRKRRTKRRKSIFSFSNNNSSSSSLDADLAFGSGYTKRQPGKSNRRSKKKADTDVDAALLGLGAAATALAASSHRKNRRTGEILVGKESRSGRSDYESSAANDEGWEDLDSGDQSSSSVTSGLAFGESGHFPSTDSHSSDSGTSRWPWNWGSKKSKKKQKKKRSRSSENRFPTEAAVAAGLGTAALASAYHRDSKVSSHDAASSTGSLQHVVPVPTSDPSHFDTIKASSQPPSQPTLVRPGPIPLQQPQPVTPVSQAVYTSQGESIPSYSVPDVHPTPASAFMPYETPSRSDRWNQRTADYTERSDISARFNRAHRRSDSSPVFHAEPLERMSSSSFRRRSTLKDQASVQFDLTEEQANKERRTNRLESLRREGDAGGGVRLVDREQEMALRDAERQASQQREREYEKSRIEEENSRREKESSSLMGAAAVGAIGGFAASTMISRSSSNDDFSETASQRRHEERREKRRAERRRVSESESIASSLTMSESGRTMAEERSQIDRLPEDVRPRQSRPPPRTKPVYEDYAQFFAPEELRYSPDTYTRREPTSMPTIIEVEPTSESAIVTEEPHPDYNGLPWPVPGLTLTEPTPPHSQVGSARATPIVLVPERHEEENRFERQTTGSRVSWGKHETHEYEVPSTSSEHESVDQDTRVLEHIEVEPITADNARDMPSSSSTQSTTKEAPTMVGADIEFAAALAAATAAAGFDPSLVTDDPTFHTRRSPPTSEPKVQFVSPWEEAPVSRSVPHGFVEGEVETPDDDENIQMAPEYRIEDGPLFSEPKSRTGEELANEPRQSIAQEVIEHLSRRKEHNASDSPAIQPSREPANKSVSEIPVEVLSMPGGFEPEESIERQEKSSDPTSTQERDSPYFVSAPGTKEDGPSTLRDTAAQSGGDIEPIDDDINSSTVGADEGEGKKKRRKRRSKRSSSDNFEDAVSITSSPARLEEKTKDTKPGSFLSNLFGSRVSAPVEDKGTSSADKLSSREVQSEIGSGRRERSSRRRSSSRGDGLDDESRKQHDEENINVEHYKSSRQRREERRRQRYEDMMESGKSSEFEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSH8</accession>
    <name>A0A8G1QSH8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_383021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510694.1">
        <property type="nucleotide sequence ID" value="XM_025656495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSH8"/>
    <dbReference type="GeneID" id="37159897"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20032">
        <property type="entry name" value="FH_FOXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF5">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="208"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH52772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="464" mass="49901" checksum="158ED0D1FB98FAED" modified="2022-01-19" version="1">MDRFYPPHGLPSDSIPFGRGLGDFTRQTETPPTSVSDGVRLDPSHHRDPCSAIGNWTCSSSASPGEPMLLSPQHQYSWKMALPPSLPAPTSLPERGLPRLLPSHRLETPARPSSLAAAGGSRTRQLKPGLRRLDDSKAPSDWLCEPGSISSCSHESTSSYRTSSGMSRSDACETACPTASLPPPSPAISALTYPSLKLETPDSPDSIDDKPYSKLIEMALKTNPEKKLSLQGIYNWFEQNTAKGRDLSSKGWQNSVRHNLSMNAGFEAVREEATPGKKAVNYWRLTNEAIKNGVQSTTRYRKQASYRKALGSDPPAPQRQRSGAKGGKATKIKSKFRGRMNGEELPKGRYHPRVTSQPRPTENVFTHYNTTAGTLTGITIMSPFQVSGLSPSGTRLSSEPFDLGSVVGCADPAPCPPLFCDMAGPGPDCVALDSGFLGWGAAVHSFPTGLLGGPRISTDLQMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSV4</accession>
    <name>A0A8G1QSV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_464590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825098">
        <property type="protein sequence ID" value="RAH51645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509567.1">
        <property type="nucleotide sequence ID" value="XM_025661997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSV4"/>
    <dbReference type="GeneID" id="37165399"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH51645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="176" mass="18820" checksum="6DB4B30F0FE274D7" modified="2022-01-19" version="1">MRKCQSGRAPHPNFLWASGCGAAADVRAFAGFYLTMEEHYYSCLHGAQLAFDTDPPLETKKTLSGSRCHSFLHTGSPRVKAGGTRLFLPKAQIRHESVTESPSSGQQPECRSITSTTTTANRDTPSTLPDYSNTSGSQTTKSSSPSLPPSPLLSGASCLHPTVPGGFFFFVGVYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT32</accession>
    <name>A0A8G1QT32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_454297</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="5"/>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510001.1">
        <property type="nucleotide sequence ID" value="XM_025661253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT32"/>
    <dbReference type="GeneID" id="37164655"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="15">
        <location>
            <begin position="34"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="16">
        <location>
            <begin position="303"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="13">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH52079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="426" mass="45082" checksum="6997F89C049F31A9" modified="2022-01-19" version="1">MLASRLTPRTIPARQWRRHFSAARPALKEIQDAYILSAARTPTAKFNGSFVSVPAPQLGAVAIKSAVSKSNLPVEKITDVYMGNVLQGSVGQAPARQASIFAGLAPTVEALTVNKVCASGLKAVALAAQNIQLGLAEAQVAGGMENMSRVPYYMARSSQLPPFGEIKLEDGLIKDGLWDVYNQIHMGICAEQTAKKYEVSREEQDDYAIQSYERAQKAWAEGLFSEEIAPVTVKGKKGDTVVERDEGFENLKADKLRGLKPAFLRDGTGTVTAGNASTMNDGASAVVVASRELAREFGTGNRALARIVSTSDAAIDPVDFPVAPAKAVPIALERAGISKDQVAVWEFNEAFAAVIKANEKILGLQNARVNPLGGAISLGHALGSSGSRILVTLLHQLQPGEYGVAAICNGGGAASAMVVQKLDRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTB9</accession>
    <name>A0A8G1QTB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_408528</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510136.1">
        <property type="nucleotide sequence ID" value="XM_025657402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTB9"/>
    <dbReference type="GeneID" id="37160804"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034438449" evidence="9">
        <location>
            <begin position="31"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="18"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH52214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="501" mass="53827" checksum="A1C79D1409B086E7" modified="2022-01-19" version="1" fragment="single">METHRPPPRKHSISFWLVFLSLRLLSFVSALDGAIISTALPKVTASLGGETDYIWIANSFTIAQTIVQPFLAQLCDIYGRRNPILISVALFLLGSGLAGGASTVGQLIGGRTVQGLGSGGIYILVDLIVCDLVPQRERGQYLGIVLSLAAVGAVLGPVLGGALAQANWRWVFYLNLPLAGPVLLFMLFFLRLDAPQSSSSNTSPSIHRIDWPGNILFAGSILSQLLALVGGGTLHPWTSPSTLVPLIIGIIGWMLFHIYEALPPKYCPHPCIPPHLFSTRNSLLGFILAFDAALLMQWTLYFLPIYFQGVQRKSPLTSGIDLLPYSAFLIPFAMVAGAIMSRTGLCRPLHFTGFAALSLALGLFTLLSANSPRAAWVCVQLPAALGQGFLATTILPAIQSSLGPADTASSTGVYAFLRSLAFVWGSTAPGIVFNARVDVYAGRVIDDETLRERLLDGRAYGAAAEFAGDWGAGMDTVQREQVREVYRLALRTVWLVGLAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTP0</accession>
    <name>A0A8G1QTP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_408580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509987.1">
        <property type="nucleotide sequence ID" value="XM_025657406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTP0"/>
    <dbReference type="GeneID" id="37160808"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="51707" checksum="A9611A7655E0FD05" modified="2022-01-19" version="1">MLTPIRVRGRRRKYPDDGAPKPKPSGPKGGRPMISHQTKLESSQARSHKRARLLVVKPTKPRQSILESLPVELIEKIFLYSLNVNFARCSSALGATVSSERIYRALILLAFWDDSSATTAVRSQAPEAAISRILRPVDYHPLSHAERRHLQDTILRCKWCTIQRLLAQLPDLMNLTIQRHWFGAGISMAPYDQESLTRFLAQKEDTRVFEGTDSNGANHYTLTVAPLVSVTITHRETNQSTTYPVLGVLLIPDKLVEDLSSPDHVTYLELLRIASGLNRADLVKPTVSVSHESLQIGIHNALIENNTAALSTLLKIDEYHFRSENQSLNPTTAVPYVLPAEHFRTAVRFARHDTTFFQLLVRASAESVPADDSEITEWAVSLNNAFGRWLLILMEHLPQQIRAAHANPAEDAVFYLGRANGQRELARRYLREVLGLEELGCWMEETMFDASALWKVDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUU5</accession>
    <name>A0A8G1QUU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_156924</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511308.1">
        <property type="nucleotide sequence ID" value="XM_025654200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUU5"/>
    <dbReference type="GeneID" id="37157602"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF21">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8G1QUW5_9EURO</name>
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        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
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                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
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                <person name="Riley R."/>
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                <person name="Salamov A."/>
                <person name="Henrissat B."/>
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                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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        <location>
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            <end position="24"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="19953" checksum="BD517BCA9EBD5E05" modified="2022-01-19" version="1">MHFHLIPALLSITTTLLFTSLVRADNDLDSDDVPDRCWSVCGPVVGITQGCDHRYDDNDRAELNCICNWVEAPTLLPLCEACIANYRREHDHDDDHDAHDNDAYDILTSCSLSTTTWNAAAATSALQSVNSTSATATATGSGAGATGTGSAASTGGSAAAASSTGDVNGAAGVSVPGLSSVAVMLAMGMGYLGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVU2</accession>
    <name>A0A8G1QVU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-hydroxyacyl-CoA dehyrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_461975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
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                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_025661819.1"/>
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    <dbReference type="GeneID" id="37165221"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF3">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="4">
        <location>
            <begin position="17"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="3">
        <location>
            <begin position="199"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH54793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="68892" checksum="09F558572C4610BA" modified="2022-01-19" version="1">MSTAATTITHPSKARPVVIIGAGILGRRIAAVFSSAGYSVHISDPSPSALDSARTYISTHIHEFATTTHSPRPSALSPGRISTFTTVPEAVATAWLVIEAVPEILPLKQSLFADLHAHSPADCILASNSSSYKSRLIGGHLPLSRRVLLLNMHFTMPPAIRTVELMTCGDTDERVFPMLSGVLSECGVIPVTARKESTGFIFNRLWAAIKREILMILAAGVSEPKEIDLLWREMFGRGEESLPPCRLMDAVGLDTVADIEENYVRERGLDGQLTVDWVRERFVSVGKVGRKAEGLGGLYPPDPSTEDVNEKEEEEEGQGPLLYLLDVGLGANTPDIEKVSTAGRILKFQPGTTGMMPVPIITGQSLPDGVDVSPTAGRIFWTNMGQSTSTHDGSVHSATLDGQNICTLLPAGTVHTPKQPVVDDTTQHVYFCDREGMSVHRVRFDGTGHEVLVQTGALDNTAHRRDMTRWCVGIALDRKNGHVYWTQKGPSKGGQGQIFRAGLDVPAGQTADSRNDVELVLEGLPEPIDLEFDEEDGMLYWTDRGEHPWGCSLNRIKVVGGLKVVVKSREILARHFNEPIGLKLDRKGRKVYVADLGGSVYWVDLQNGEKKVVWRDEGCYTGVALISAGERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QW51</accession>
    <name>A0A8G1QW51_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidyl-tRNA hydrolase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_162228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511202.1">
        <property type="nucleotide sequence ID" value="XM_025654241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QW51"/>
    <dbReference type="GeneID" id="37157643"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110916">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="2">
        <location>
            <begin position="116"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="256" mass="28019" checksum="B7A89B0877C82573" modified="2022-01-19" version="1">MSLFLSVLPAAARHLPSPRTATAATTAVTTAAANMVRANHVSRGLESIMAHARLSLPRNFHRVSLACYYPPSSRPTVATRTFASRRAAAISTPSGLDSDHHLTAAREWVARLNSKAITIPRDICEISFSRSSGPGGQNVNKVNSKATLRVPLKSLLPFVPQLLHAPLQASRYVAAKSQFLVIQSDESRRQTANVEACYDKLHQLLKSIAEDTIPGETSQEQRDKVQKLKKAANEARIKSKKMHSSKKSSRRGSYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWS3</accession>
    <name>A0A8G1QWS3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_479766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513225.1">
        <property type="nucleotide sequence ID" value="XM_025662971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWS3"/>
    <dbReference type="GeneID" id="37166373"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="18"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="164" mass="18303" checksum="A838EA6F38D70BBC" modified="2022-01-19" version="1">MAPKKQMVLKLTSFRYKKEGISEKEFHEYASKSHAPKAAIVQARHGAIKVCQYHTPSASKRLITEKIPWAVRPGWEIEDHDIMVCVYVPNAETAQAIVTDPDFQSLVAGEDEICDQTRAKLTAGWEEVFVEDGKVVEADYGTFEELTSLGHDSKPTSAPEGIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWY8</accession>
    <name>A0A8G1QWY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_451694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513315.1">
        <property type="nucleotide sequence ID" value="XM_025660649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWY8"/>
    <dbReference type="GeneID" id="37164051"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF25">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH55393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="499" mass="56742" checksum="87661CF9D4B66911" modified="2022-01-19" version="1">MTPSRKPRHRLIAGCQRCRIRHLKCDTNSPACSHCIRAGTDCDRGINVRFRNGLDIFGDDDALFPERNLWPYLMGPLRFVDETVIIKQLYEAEEPEHNGPAEQSRGVNDAPITPVGVVEYHGLEQYTSPLTDDTPPIQTLRHDGRSSELELLMGNALQRSDTVTGRELQASDLVQQQRLSFNEREAKLMRNYVENMALWADITDPHRHFEVEVPVRAMQESVLRYAIFALSSRHVERQKKGNEAEALQYHNHCLQLLIPTLSGTGGDLTDVVLATVAILRQHEEMEYDDNQFHLTGATRIMNTVSSFGSSGGLGEAAAWLCLREDIHVSLISQKPLRTNLESFHHSDIFLRNDDFAWAARMVFLLAKVLKCAFNQMSLPEYTALQSIAQEVEDWNARKPPSFQPLRYLPRGKDVSRRFPEMWMLLPVHVVGIQYYHIAKIVLAIACCPSLPLAYESFRNSRNIEKAIRYHLFMVLGLAKSNPKAENTLFTARHSLVACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX16</accession>
    <name>A0A8G1QX16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_379008</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512354.1">
        <property type="nucleotide sequence ID" value="XM_025656321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX16"/>
    <dbReference type="GeneID" id="37159723"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH54432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="400" mass="45734" checksum="11E28A10DF787037" modified="2022-01-19" version="1">MSILSRSAGSYGCPIPDHLEQLDVGPFVGNLTFYQFNIIVSGVCTAIVLSLILGLMGRHAMHMSNPNEQLKIMRICNLIPSYQVLSYISICFPNSYIYLQGFTEVLQGVALYAFLMLLCDYMAPDDKSKVKFFSSLETKRQWQPKKKRNGLAFLSLTWYSVLQYPVITWITAIVQVVTQSMHVYCLESNAPHFAHIWLQVVTSVSTSIAINAIIQFYVNMKGYMTEHKPLLKLMAFKLIVGLILLEKILFLILTSTKVLTYPPSMTYIDTLMGLPTMLICVQMVPLSFLVLYAYRTKPYEISTSVSRQRPQAYQALESDQDEEVLLNDPPKRYQGGAWGLRAWAMYLNPLVLIKDVYSAYVMIHNARSLQKVQQREEPEQEEMAGWETSYDPCERSRRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXM2</accession>
    <name>A0A8G1QXM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_451747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512793.1">
        <property type="nucleotide sequence ID" value="XM_025660661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXM2"/>
    <dbReference type="GeneID" id="37164063"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086:SF1">
        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10303">
        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="443" mass="50354" checksum="0ED50CA67AD958F6" modified="2022-01-19" version="1">MDSPAVPAPLDPKEQPILERLLRTRDALILLKQDKSSYIKSRDVLPLYEEVVAEVEKLNAARKEQDRRRAHNRLDYVLDDCFQLISLLFLTVGRNNEAPAVYSLATTVQRLLDHLEEAGFYSSKDLISITKTLANMNDTLERCRQAYSPALITLLESRLEKCQLLLEKLQSGLAKLGPELAATHETLVSILRSTSAVNTRSKFSSSEVTALRTQLKKIEEGMKDGQFVDAEGVPLSGAQEDVKLLMERCWLWTEIVLERQGKIDERFKEQYDKLIEIRNQLDRLAVTQAWSLRETDLFGYQRKLDRIDEARVNGNFVDAEGNAADIHAQRTLLYLIRRSYGYIYALLISSEPVSEALLPVYNQLQTLRKCLLEVQESGGVSNSRELYPYSMKLNSIDNMRVDGKFYVGTDIPEGQGSVNALLAECYDIVWELRAAVDEDERTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY47</accession>
    <name>A0A8G1QY47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_460864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513680.1">
        <property type="nucleotide sequence ID" value="XM_025661742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QY47"/>
    <dbReference type="GeneID" id="37165144"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH55758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="337" mass="39804" checksum="52E1A175F6C845CF" modified="2022-01-19" version="1">MAVVTEQRQQECCYSVQVPEEEVEKHRCFTALPIRRHKRFREVDAVLHDLIRQWHDIIGDGASDNFNYTGDPVSGSWISLILPESNDETFPHSAWLTEFFFLFDDKLESMSHQEVKENVEAVHKIFSSDDPESSESETAFGKLLVPFVREYLRYDYKRGIPVLRGWKTWLELDHTNENDFNTLDDYMTYRLVDIGMWAYPAMAVYHMQLDIKPEQMDSLKQVFFLMEKAIIFTNDYWSWPKEAANFRRGSKRVMNAVLVVMRELQIDYCEDARKIVKEKAIGYEKELLHLRNQLFSPEYQPPLTSDMRSHVDAHLWMVSGNNLWSSTCPRYHSQKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY65</accession>
    <name>A0A8G1QY65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_490699</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512969.1">
        <property type="nucleotide sequence ID" value="XM_025663670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QY65"/>
    <dbReference type="GeneID" id="37167072"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056024">
        <property type="entry name" value="DUF7605"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24564">
        <property type="entry name" value="DUF7605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="3">
        <location>
            <begin position="241"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7605" evidence="4">
        <location>
            <begin position="849"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="612"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH55047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1090" mass="123509" checksum="76BC2015D26DE2EF" modified="2022-01-19" version="1">MEQRDLVSRPRSVSRAPREEPQSSQNSEIDVLQFAELHFVAEQTAKHARCWEGQVDRPACLDFKAIWTCITPRMRELYVDRVKYVETKGWDWIYADYEGSLKCCVDFADFKALVDNYDGESHVPQDNVVKEEVDDRDVVPESMFVDQDEPEPEPRPEPRADFPDEDVATADSVEESPLECDIKIPANEEIVALENAVGKGVEILKKLYAIFSGSDAFGNEADWKAEIERTQRYACTEKVIIGLVGSTGAGKSSLINAILDEKNVLSTDCMRASTAVATEISYNQGATKYRAEVEFIERHEWERELEVLFEELLDHQDEVTRGAIPKNSDAAVALDKIKAVYPMLTPKDIFNASVANLMASERVTDLLGTTMGFEGDDPKAKGKRGRPKKSAKKQDADEHPDSASDTDTANQGIGLWPLVRVVRIYTKAPALATGAVLVDLPGIFDSNSARVAVAEDYMRRCSAHWIVAPINRAVDDKVARDLLGKNYKLQMQMDCAFNDMTFICTKTDDLAPTEVIHSLGLDLPAFNEVQQLPAKVEWLKNEINAFEKPKKTILSRLDWIETEIEELEERLTGDEFGCDVLEITPKRKKPHGSEPLEMPAIQEAGTTEIPMVEKLKNRFSDLKVQRKDLRSQLKHINEEMDSKVEELKELEDGKEKMEHSVIKSCIEARNRFSKQQIKRDFALEAAGCDYDELERNLPVFCVSTRAYQGLRGRADMAKLVGGFSELEETEIPLLQRHCVRLTEKAREESSRRFLTQLNQVLQSMKLWCLVSTATSDASEQKIKEIEADFESVFGGLTEAAEAHMNHFDSVARETVQVSIFNKLNRASRHAVVQFPEAVSRWNAPGNSGGLRWNTYKAICRRRGVYHKIDWNQDLARPMLDKIASSWKRTFTELLPHCLHHLKENLEAVVSQFHTQVIDSVKQGVPEKIRVQLQDTLVACRQTMGEQFRQAENWTMQEQKRINRTFAEAIAERLKETYQACASETGETLSQLVEKYSNMLITTGRGSLQRSTESAKHELGKLLDGQQAEVDRIIHNRLQRISKDYHRALIEPQIKLYTEEQIRMKSEVAKIVKEAEAELLLGHLLGGVRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYF0</accession>
    <name>A0A8G1QYF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Outer kinetochore protein DAM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_470180</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513784.1">
        <property type="nucleotide sequence ID" value="XM_025662381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYF0"/>
    <dbReference type="GeneID" id="37165783"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH55862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="204" mass="23087" checksum="4167A261C5B27BC4" modified="2022-01-19" version="1">MDAFARSSSRPRPSSRPTTPLRPSSRSSIREAHGYGSSIGMAGYTQPAINALEPQFAELADSMADLEANFMHLQLMHESLTRFSESFASFLYGLNMNAFCVDFPEDYGHFLHRTSFEHRSLQAFGQNSGPVAWHHQRIHAWFDKQSLCDTGRQSWRPAQRIAPRTRIAVKAGTRMVEIFNRAQTVEHGEAQRLARRERPAIGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYL3</accession>
    <name>A0A8G1QYL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF500 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_41646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514723.1">
        <property type="nucleotide sequence ID" value="XM_025657734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYL3"/>
    <dbReference type="GeneID" id="37161136"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF8">
        <property type="entry name" value="DUF500 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="153"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="661" mass="71858" checksum="892B3BEA3E5E8ADB" modified="2022-01-19" version="1">MPSTLWEKTKGTSKKGFDKAWHTLDKLGDPVNRLSYKVGAEAFWPMTLDKESDKAARILRSFCKDGFYSNEDAERQSTDSSVSKESGKIDRPKGKQRVLKKIPARVIQRAKGLAIFTTMRTGLWVSGSGGSGVLLARTPDTNEWSPPSGIMLHTAGIGFLAGVDIYDCVVVINTYEALEAFKKVRCTLGGEVSAAAGPVGMGGVLDSEVHKRQAPIWTYMKSRGLYAGVAVDGTIIIERTDENERFYGERISVTDILAGKAKRPPASIQTLLNTVKAAEGNPTVDENLLPPGETPGDVEIVPGPGSFGIPDPEDPDPFGVKALEAEGLFIREAGTKSRPSQEAFEFKPGPNSPVFATFRRSVDSSPRNSWRASVQSYASMDRGTQTDDGPTTAPTSISRASSRSYRDVSDRAETSPWDNEEGRWETVIPEHDEYHGRDDVEDVDLDDDVEIHEVSSATVSKRESAAHSPVPVEDSIAPVEFKRHSPTFTRARLVTISKRMPPALPPRNPQRTPAPVSTSTPSSPTVNPYAHSRRRSVASSPGHATYGFTEMPLYHKSDSESDLSSTGAPESSNKPSPDREEFHSVSSLHDSDVASETEANEAKETETEKTHEASSDASTPTYVHESDVSPWAKSDTDLAPTKTITSEDHVKVESTVQPQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ97</accession>
    <name>A0A8G1QZ97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_404117</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="RAH54040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_025657257.1"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:zinc ion binding"/>
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    <dbReference type="GO" id="GO:0006351">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
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        <property type="entry name" value="TF_fung"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
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            <begin position="78"/>
            <end position="108"/>
        </location>
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            <end position="202"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH54040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
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    </evidence>
    <sequence length="822" mass="90897" checksum="467E2B57EF78ADCA" modified="2022-01-19" version="1">MPEPSQKRKRAKTGCLTCRARKVKCDETRPRCIHCGNLGVECRWPEPATKRFCRVSTPSSCNTQEPQSIATGGPRLSACFSCRYARSKCSKDRPICARCRAQGHECKYPEPQGSHSLTSSAQSWMRRLQTAELGNSAEPSHPRALTSLTSSPEPESAPGHPETTDDQRQRIRPVDASPLETSDRLDDIVSAPRGSQSSPLQAVAGAVVTPGPCMGIRPSQDSIERLTVAFFRHVHVYRANAFLHRDQTLMAIRDGTLGTPVVLALCAVGARFTSPPQPDDVVISWATEAANWVTTATEVSRDHVVVALLLAIYMQQAGRFAQSHLWSSIANSHAVSLGLHREPAPGTSSFVESERDRRLFFACYAIGRFISNGAPESIQCPASRIKLRLPCDGFNYRLDVSIETPYASLEADEAETSGPNGMQRNVGAMGFWVQLVSVRMKIKRYFHSLTEDKEERHTHHQSSAIGTELAPWGASSPFVISLTQLASLSESLPPRLQLSRELVLRRHDAPVLGQIVMFYLWWNECHLELYSIALHGYPQSLDPTVMSTAPAGWIDQARHNCLRHAQAITDILDLVDREMPRQPLTISDHTIAHVVYLSVRVQLELLVPTLKDAGVRLELKKKFDMMLGFVERTSKYFHQVFLVLQEMRRMLACHELASGTSESEDAISQTASLPWFCRQKALDSRRAAEQAGITAAHLQVNLAEILPDCIPFGTMSWVRGYDVNDPCRLPEISEASWDILPNLWLGGPPNGQTTHNPVTGMTDFSNLGMFNTWGRMDPSGTGSRFDPLLPNHSFAHPNATGPCGTSNVISSDASFSLHSLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZB7</accession>
    <name>A0A8G1QZB7_9EURO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_449905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025660264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZB7"/>
    <dbReference type="GeneID" id="37163666"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="57" mass="6510" checksum="D44E297F75732956" modified="2022-01-19" version="1">MVHTQDSATYFRVISFRHDSGSFRKKNPPHHQTMPYASYATTFPSSAVDHGLQRMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZZ2</accession>
    <name>A0A8G1QZZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial inner membrane translocase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_305415</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
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        <property type="protein sequence ID" value="RAH57536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH57536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="154" mass="16049" checksum="AF2BEAD675643FBF" modified="2022-01-19" version="1">MDHSRDPCPWVALSDFGGAFCMGAIGGAVWHGVKGFRNSPYGERRIGAITAIKARAPVLGGNFGVWGGMFSTFDCAIKGIRKKEDPYNAIIAGFFTGGALAVRGGVKAARNSAIMCAVFLAVIEGVGIGFQRMMADNTKLELPPAPPSGDKAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZZ7</accession>
    <name>A0A8G1QZZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GPI-anchor biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_398872</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514594.1">
        <property type="nucleotide sequence ID" value="XM_025657072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZZ7"/>
    <dbReference type="GeneID" id="37160474"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH56672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="308" mass="31786" checksum="3580D8B32CC70944" modified="2022-01-19" version="1">MASPPPSPLTTNSAASAPPDTSNKPAAPPVNILPTQLATTYSYIHPAALLSAFAARFPALVNDPVSEMAQQLPFLALAHVAYVMICLPAAGTDSATTTAAATPTSPSTPTAAAATSSASSTTTTTTGSTTNGNVILRPGRVGRRRTKDSSSSSSSTASAIRGRVVASLLSLTLTTLLATPVLSILLILFGAPFTTHHAQTVLCAAHMAILSSLALVYVHGVDGNVWKEVWGAKRPGDVVWGGALGTCVGAWLGAVPVPLDWDRPWQAYPITLLTGAYVGFVLGSVLGRSVLFGKRVRFEEGEDVKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0A6</accession>
    <name>A0A8G1R0A6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_469230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515085.1">
        <property type="nucleotide sequence ID" value="XM_025662319.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37165721"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031359">
        <property type="entry name" value="NACHT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17100">
        <property type="entry name" value="NACHT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NWD NACHT-NTPase N-terminal" evidence="5">
        <location>
            <begin position="84"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="6">
        <location>
            <begin position="362"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1049"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1175"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1217"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1370"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH57163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1501" mass="170127" checksum="A60F69255A512E1F" modified="2022-01-19" version="1">MGCPKLRNPFRKRRPKQQPREETTNLSNIPPQISFNALSGTCSTLEPVAQPKPKADALPAEDKQVQLSSDTILPHLNRKTEKRNLWQEAYNTLDEKQRQNIKPLKKNDQNGDNHDDNATPVRKTLDDVIRAVKAQYEIRMSKRGDSRLRDAANKILTATLSCKDIISAIVAFDPTAHASSAWTVVSLGLTMTQNYRDQQMAWFQSSAILTDILARYAVIEKLYRDESSEVNDRIEDAILRVYIAVLKYTAEAMTIYRSNTGKRLMRSVVALANLPLTEIQSSIDTEETHLGKWLQMFQEMQRKEEANNILLGVDRILDGIRGIDQKLDLAKLPIAEGAHFNSHMDEDQVECLENTRVELLDDITDWVDDPKGKTIFWLRGVAGTGKSTISRSVARKLHERDLLGASFFYKRGEGDRGKASRFITTIVKQLMIALPHLRKEIAAAMEDDLIVSTSLKDQFDHLLLKPLLSVKLSNGQRLPLVIVVDALDECEERSIETIIRLLPRVQESKTIQLKVFITSRPEHPIFEGFEQIEGEHKDVVLHEIERRTIKHDMALFFEDRLSKIRKNKNLEDEWPGETETQALIDMAIPLFIFAETVCRLLGDYRWDPDDSLKDILKRRYNNSNLDRTYLPVLDKLLEGQDRRAQNELVKQFRQVVGTIVALESPLSIASLSKLINMKESLIRTRLDSLHSVLSIPKDNNRPVRMFHLSFREFRLHPETKEKTKLSVDGQSTHRDLAHKCIAVMMDPQHGLRQDICDLRKHGTSRDDITTEQIEGCFPAELRYSTRYWVRHLHQGAWILSDHDEIHEFLKKNFLHWLEAMSILGHLPETIGSVNMLLSIVQTSHSDRISKFLYDAKRLTLKNIHIAKEYPLQLYSSALLFAPEKCTIKKTFLHYVSPYFSRLSRVPEYWGAELQTIEVGYQYLRCLEFSPDGELLLTSTNKLSLWEASTGDLRHTLEESTNLEFGLCAFSPDGKLVAGTNWDSSTIRLWDSLAGTLRHTLKGEHGTIAIGFLNNEQLVSISFDRELSTWNTISGELQQSVRLEVLRHTLKSHGRDVLSLAFSPDGRFLASAHMKSILVLWDICKGTELNTLQCHANDCCINSVDFSHNGRSLALYCEQGLTIWDICHSPILSTFASRKTVIGLVKFSPDNKLVASSTLGQVTLWDTTRCEVQHAPQGHTKPVTTVQFSQTGAVLASSSRDSIVRLWDISTGTVQRVLQGHSDAASGVSISPKGHLVAVSSKDGLIEIWDVSNGTLQHNLSSNCSKITNRMLFSPDESLLLVIWDSRMFLWDAVTGTCKWTVEPKRPDPPMSDVTDSSDSSTSFGYVETVAFSPSGNFLAAGFWRKHTVRLWNIGTGMAEHVFTDCSTDQIQFSPDGKLLAAGSVSTGVKVWRVSDGGLRQTLEKEDEPSWFRYATKSDGYSWLFDTNVNEYRIHPKSQGNIISVTVNWIGIGKDRFLWIPPEYRGNRYAREVIENTVILGLETGDVIFMGICPEKVREAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0Y2</accession>
    <name>A0A8G1R0Y2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_521518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514171.1">
        <property type="nucleotide sequence ID" value="XM_025665205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0Y2"/>
    <dbReference type="GeneID" id="37168607"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH56249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="231" mass="26513" checksum="A96201DFA65E355C" modified="2022-01-19" version="1">MQALSSNGDVYARGCSAQACRKAQVQSKIAAEFVRLDPVSWEWVLGIWKKATKATHTVRSREYHSLEEYLSFRVSDAYAEWALALFSWAQDIHLTDDEERMIDPIRHHVYAAMTLTNDYFSWPKEYKAHMEDQEIPLINAVHVVMQCQSCSEETAKEVVKAEIRRHETLVSQFDEKYAGSPQALLGVIKWLRMCETALAGNYIWSSQAPRYFDVESNPYKDHLATLTGESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R105</accession>
    <name>A0A8G1R105_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho guanyl nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_451038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513722.1">
        <property type="nucleotide sequence ID" value="XM_025660509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R105"/>
    <dbReference type="GeneID" id="37163911"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="156"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="822" mass="92200" checksum="F2BDDCFD44A0860E" modified="2022-01-19" version="1">MEESKDMGEPPLLILEKPEYVVEITATHPMPADPVAAFKRWMNSFRSRRGCPPPERYVEGWPMEVKPDDRDLLPDLLTSNEFQEKQWESLSHRSSNLGTVKTATLSITSQSVVRSRGTTQSTTNQSIRSDARESLDSIRPALNPSIDEEAQHRAIKRRRVLRELITTECDYIFGLKALAEALFIFSVRPEIYHNVQQIRDTHEDFLSQIRKLTPISNLAAAEFDTLMPQGVHKRLSAIDFGLRALHAKSLRSRSFRTSMDSRLRALAAETKEALQVALEVGNLSASFKAYKVFCKNYGLLTVDVSLLRQSVPDWRIFDQGIEALSKSVASLDRQAQEENKAMSLNDLLIKPIQRLCKYPLLLEELLRWTHIQDDPSAHDGIRQILEQVRAVVCEINQITDNPVSKALVKKTFLLQSFMDLSAANTIDNIYKQLGPLSLCGVLHITYQTPEYITGGYMVCILFTYHFVIAKPSDDYRRLEPLTCLYIPDMKIDSIRNGEGLRCYGCLFSWKLIFQSQGKNYELVLSAASAREEKKWETEMLKSAAALTDMPKSVVAKLKEHSFLTLELAPLSGSNGVLPLIPRRPSMQALATSRTLPDSHNIIIKKTHCPQRLQMTESVDGEIERPKMSALCPALVLTARRQDRILLERAISAFYTRDVLPYPGMTLGKGDIFHSPGSLMRHLSRRPGLYRRSSCVSLSTAGYSAKSVTGATCADEKVHRKLGKSQEKSLRSVSRGKPATPDTDKGPILARHSKDIRRSKTWKGKGGPNAKAKAEIIPTSASNKGTETPDACSLRTSAIRRMFNSMSSRRTKRQGRMGLGSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R196</accession>
    <name>A0A8G1R196_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">laccase</fullName>
            <ecNumber evidence="4">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_520153</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515315.1">
        <property type="nucleotide sequence ID" value="XM_025665107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R196"/>
    <dbReference type="GeneID" id="37168509"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000046">
        <property type="entry name" value="Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF502">
        <property type="entry name" value="MULTICOPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034400902" description="laccase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="68"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="191"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="407"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH57393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="564" mass="62333" checksum="DA15E74CFA8C1202" modified="2022-01-19" version="1">MHLHTILAAGWLAASTAYAAVSSPSTQACAGNTPQTRDQWCDFDIHTDYYTEAPDTGVVREYWLELGNTTAAPDGVPRDVLTINGTSPGPTIYANWGDWVRVHVYNGLENNGTSIHWHGVRQNHTNPQDGTNSITQCPTPPGGSITYEWRATQYGTTYYHSHFALQAWDGIYGAIVINGPASSNYDVDAGVLWLMDWSHRTADQMYSTAETDGEPEMTTALINGTNIWVKENNETVGERFLMNVTAGQSYRLRLVNGGMSNLFRFMIDDHTLTVIAADFVPIEPYNTTSLNIGVGQRYDVIVTANQAHAGSDFWMRAIPQEACAEIENTDIKGIFHYEQLNTVVATPTTTAYNYTDSCYDEPLSSMVPVVAIDASGVGFRSHNEANVIMNSAGLYKWYMGPTTFKAEWDNPTLLQIANGNTSWTNTSHVVEVEGNGKWVIVDIEMTINVPHPIHLHGHDFFILAQGDGSYTSNTTLNTYNPPRRDTAMLPALGYLVIAFKTDNPGAWLLHCHIGWHQSEGFAMQFVESMPQLEPMIDTSALEKNCAAWDKYAAANSIEEDDSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1D2</accession>
    <name>A0A8G1R1D2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_522040</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513057.1">
        <property type="nucleotide sequence ID" value="XM_025665228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1D2"/>
    <dbReference type="GeneID" id="37168630"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21386">
        <property type="entry name" value="GAT_Hse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="15">
        <location>
            <begin position="16"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="232"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="391"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="527"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="576"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="614"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH55135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="629" mass="69934" checksum="FFD603A8C10E2B7A" modified="2022-01-19" version="1">MFRAQQNAFDDAVAKATDENLTSENWEYILDVCDKVGAEESGAKDAVAAMIKRLAHRNANVQLYTLELANALAQNCGPKIHRELASRSFTDALLRLANDRVSWASTDEEHRTYTEQNTHQQVKSKILERMQEWTEMFASNPDFGIMEQAYMKLKTQNPNLQPPSKPGKREITDSDRQKEEEELQMALALSIREKATIAPAPQPEASSSAAPVNQNQTPAATSQAVPSGTSAATVSRVRALFDFQPSEPGELQFRKGDVIAVLESVYKDWWKGSLRGQTGIFPLNYVEKLPDPTVEELQREAQMEADVFGQIKNVEKLLTLLSTRSSELNVQDNEEITALYHSTLAIRPKLIELIGKYSQKKDEFTQLNEKFIKARRDYESLLEASMAHPAQPQYGRPAQPPYGYPGAAPVGYPQGPPQADPKRYFSPRPQESQAPPANAPAFYSADQAHAYPPTSQSPDPRQTPPAGAPYQQSQQPPLQQRQPSSESYQPVYHRPESTYENPQELGTSVYDSPVEHPASQRPPYPGAVQVPAAVQQHFQQQQQPQQQQQQQPHPEYPASGYAPEDASRPPTHQAQPPYPSHQPPPMHQPPPVPGTSTTPTPYPALNAGGGYQAYNPSQTDVSNPASFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R270</accession>
    <name>A0A8G1R270_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromosome transmission fidelity protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_451310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513447.1">
        <property type="nucleotide sequence ID" value="XM_025660561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R270"/>
    <dbReference type="GeneID" id="37163963"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018790">
        <property type="entry name" value="DUF2358"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031342">
        <property type="entry name" value="Mug163-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094:SF2">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17119">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="40259" checksum="EC8C4BB9FA797DB8" modified="2022-01-19" version="1">MPPKLVSGPAPRALRRRLLPPSTSSPIKPPVSREQYFVSPSPRTLAQPRPDIIHGPQLTRESPTLFSQTGFRPSVSDPLDGGSKRDHEPPDERILKLGKTLRILSPLLPTLLINPLPPNILSPSIALHLFPSTHPHLPTVKGRTLYRAALWTVPVAWSSLPLLGNVKLQILSERIVRAGTVLEPERPDNDHDTSDERLVVRWRTEPRSESTTSNSEHSSTSFTAASPTLPSDTQGTNKSNGTHLSSSKAGINKGLSVLLGGDAPIFKLKKEEQFTGLFIFSFDEEGRIASHTIEHADDARGWNRTPKFVTLTDWLIGKARGSLDPAAEPGLAMQGCHWQDAQEYLDRDRYHREQHYYPHGRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R278</accession>
    <name>A0A8G1R278_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SWI5-dependent HO expression protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_374751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514367.1">
        <property type="nucleotide sequence ID" value="XM_025656142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R278"/>
    <dbReference type="GeneID" id="37159544"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="270"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="39993" checksum="6F769FC52FC4C067" modified="2022-01-19" version="1">MARFGRVKKSPKAGTKNADSDMLVLPTSDPQRAPRVSLPHVETELNMHQYNGLFEIGTPERQKASAAEESSTETVVTPSPNGTNGIHNSISGDVPATEWSSAVGHAATGKSGRVIHNLQEEVARLTRDCSVYRSRAEETQRMNDAFKIQVQNMTERLRNLEQANETNLHSISRKDKKIEELRLEIQGEKDRRSHAEGEARKTTQLMDEARDDFHRKCAELQEISHHSRTQYDVLAKTGQRERAEHLKKLKVLRDDFVALKKRSDEKDTHVERLDELMAEKDRELESSRQKFEALFAEYEAYKRTQDEELRSLIESGREGEAKINAALAALQETQGQMKWAIQVKHQIKDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R335</accession>
    <name>A0A8G1R335_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_448098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517078.1">
        <property type="nucleotide sequence ID" value="XM_025659867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R335"/>
    <dbReference type="GeneID" id="37163269"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF7">
        <property type="entry name" value="SERINE HYDROLASE FSH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="214" mass="23530" checksum="A454B54294BCD3F2" modified="2022-01-19" version="1">MRFLCLHGAGTNAEIFEIQSGGISYDLAKYGHTFKYYNGCMEAEVEPQLKGLFNGPFYNHYPRDRAPGEYLAPAMKHVYDIIEREGPFDAVMGFSQGAALACAMIVHHAKTHQEPLFKVAVFICGAAPFDSTGNEVIPDTSAEGEYPVKIPTANIVGKQDELYPSSMHLSRLCEPSKMSFHDHGSKHMVPFDVENTNAMVAAIEAAVQKALRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R391</accession>
    <name>A0A8G1R391_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_511920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517168.1">
        <property type="nucleotide sequence ID" value="XM_025664626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R391"/>
    <dbReference type="GeneID" id="37168028"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="173" mass="18909" checksum="49273B9740183F3A" modified="2022-01-19" version="1">MAQKVHTAQEDPERPSNLLGFGMGAIMLAKLVKALMPSSISSNSSSSSNSSGSGGDFLSSYDSGSTSECDLDNSHWSLFPFYYCDRLQTQSLTEQNHYTRPGKPTGYTRIADVILKSNLGLEEAHLISDRSSLALSASYGGVYFQGTCRYEVSMDVDVGWAWAVHSKVWVWMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3B1</accession>
    <name>A0A8G1R3B1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_449460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515401.1">
        <property type="nucleotide sequence ID" value="XM_025660171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3B1"/>
    <dbReference type="GeneID" id="37163573"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF11">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH57479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="533" mass="59009" checksum="272DD1C804BC2C86" modified="2022-01-19" version="1">MYEQIDVDDRELEAQGYAPAMPRRFSLLSLFSLGFALTATWNGFGSAIGASLAQSSSSGTIWTLVIAALMNFVVSLGMAELVSAFPNSGAQYYWSYKVASPEWAPFASYMSACISTCGWWLGLASVCNFVAATILAILQICVKEYTLCPSHQWFCYVAIIWLAALLNIYATRFLPALNQYLLYFSVSTLLITILVILVCAAPNYQSSVWVFTDTTSFNTSYDKSFLFVLCLLNNTYGFMGTDAGAHMAEEIPSPSINAPKVMIYPVIIGLVTTWPFAVACMYVITDIERVVNPPSEISLVEIYLQATESEFTTILLLAAFAICLFGCAAANITGSSRQIWAASRDNCYPLSTWLAEVHPKHKMPMNAACLTAIFATLYGLIFLRSSTAFASMVSANIVFMMTSYVIPQGIAVWRGRSSVLPIRHFNLGIWGSFVNITSCVWVCFLDIVACFPIIRPVTAANMNWVSVVIFITTAYMVLAWYLWQRHVFRGPRLNTRFIQNSRSRAASLPHKHSPCGLIDQPNNETIDKDGKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3E3</accession>
    <name>A0A8G1R3E3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_468187</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516440.1">
        <property type="nucleotide sequence ID" value="XM_025662238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3E3"/>
    <dbReference type="GeneID" id="37165640"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="409" mass="46714" checksum="3220E9B2E8FA8C95" modified="2022-01-19" version="1">MLGHTTMPVPVLDTALNPKKHFELTSTRVKWEFFFNAQRLLRDWFTTHPSTPVPLHTDVGEMTMLPPSMANEIRNKEHLSFSQWAMKAFHGNLPGFDGFREIGQDSGIVQAVIANDLAKYLNKVTEPLADETSVAVRELLTDNEEWHTIRLSGIMVALICHIASRVFLGEKLCRNEEWLRITQSYTIDGFLAMTELRMWPAAIYPILRTQVSKSRKVKQPILEERRQLKEGLILSVGAIHTTSDLTCQTMTHLVQNPEIWEPLRKGIVDTLQQHGWKKTALYNMKLLDSVIRESRILKPVTKVSMRRMVLQEVKLSDGTVIPKNGMLASQAQPVTTAPENLASGHGKHACPGRFFAANEVKIVFIFLLLRYDWKLLEGMVPRILSGEFGMELDPTLKLEVRRRREEMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3L0</accession>
    <name>A0A8G1R3L0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">26S proteasome regulatory subunit RPN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_449834</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515042.1">
        <property type="nucleotide sequence ID" value="XM_025660246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3L0"/>
    <dbReference type="GeneID" id="37163648"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="195"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="8">
        <location>
            <begin position="882"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="914"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1039"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1121"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="915"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="942"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="953"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="966"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1044"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1139"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH57120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1148" mass="125694" checksum="B9E105BEFB98C8D6" modified="2022-01-19" version="1">MVGLASAAGLVGFLSEPDPELRVFALKTLDSQIDLLWTEVVDAVPQIEALYEDESFPERELAALVAAKVYYHLQEYNESMVFALGAGKLFQLDSGGEFEETIIAKCVDTFVSLSAAQRPVAGDQQANLNTSFPTSGEGATSTSASLTSPITPFSQSALPSKSLLSRQEVPGVDAAYPGGEDAGVKHAEETPLVLKRGVQGHLQTVIDRLFEQCFVQKRYRQVIGIAIEAKNLDVLRKTILRASEDEKKQNGESRRSEELMEYVLDICMGIVQERGFRNEILKLILELLNEIPAPDYFSIAKCVVYLNEHSMASVILRQLVEKGDARSLAVAYQISFDLYDNSTQEFLQKVRQEISELVPEKDESEQEAAGEDQEESKESDPLLDSQSRSIGDSHAKISPEARTAFKSIRDILDGVKTNQLNVEFLFRNNKADIAIMNKLRDSLEARNSIFHSAVSLSNGFMHAGTAHDKFFRDNLDWLSKAVNWSKFTATAALGVIHRGNLSQGQKLLQPYLPKERSITNVAAGGHSGASSIYSQGGSLYAYGLIFANHGGMAVPVIRDYFKKATDEVIQHGGALGLGVAGMASGDEGLYEDLRNVLYTDSAINGEAVGLAMGLIMLGTGNMKVLEDMIQYAHDTQHEKIVRGLAMGMALIMYGRQEAADELINGLLGDPDPALRYGGIMTIALAYCGSSSNKAVRKLLHVAVSDVNDDVRRIAVLSLGFILFRKHQSVPRMVELLSESYNPHVRYGAAMALGISCAGTGLDEAIDLLEPMLKDSTDFVRQGALISLAMVLVQQNEAMNPRVSSLRKVMMKMIGDRHEDAMAKFGCAVALGIIDAGGRNCTISLQTQTGNLNMPGIVGAAVFVQYWYWFPLTHFLSLSFAPTSVIGVDQKLEVPYFKFHSNTRPSLFDYPPEQQVKAEEAPEKVKTAVLSTTAQAKRRAQRREKQQRRESMDIDQTPTTPKVSDQVPDKMDTDETAVKTEEENKDGEKDAGEGQKKKVEREKVGYELENMSRVLPAQLKYLTFPDPRYEPVKRPTGGVVVVLDKTPEEPRETIEMTASKETSREARQPAPAADVAESLQDRLQATMGAAGLQTPQRGAGRFPFGADLGPFAGAAAAAGVLTAVDEDEEGGEEAPVPNEFEYESEPEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R437</accession>
    <name>A0A8G1R437_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_519025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517125.1">
        <property type="nucleotide sequence ID" value="XM_025665012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R437"/>
    <dbReference type="GeneID" id="37168414"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="65" mass="7819" checksum="A1460CFCF47EF698" modified="2022-01-19" version="1">MDTFWVAESAGYESHGWRKRKGGKIRDGDFQRMQQVVIWVDWVPGYDAGMRSEESWRAYYFSYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4F8</accession>
    <name>A0A8G1R4F8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ribosome quality control complex subunit 2</fullName>
            <ecNumber evidence="4">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Threonylcarbamoyl-AMP synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO85DRAFT_394398</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NEMF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="4"/>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516919.1">
        <property type="nucleotide sequence ID" value="XM_025656923.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37160325"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000008">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000003">
        <property type="entry name" value="Zinc knuckle domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="18">
        <location>
            <begin position="1128"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="694"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="842"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1018"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="725"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="768"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="810"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="843"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1039"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAH58997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1522" mass="167458" checksum="76D3E7B002402ABD" modified="2022-01-19" version="1">MKQRFSSLDVKVISQELASEIVNLRVSNIYDLSSRIFLFKVAKPDHRKQLVVDSGFRCHVTQYSRATASAPTPFVTRMRKFLKSRRITSIEQIGTDRIIDFSFSDGMYHMFLEFFAGGNIIITDREYNILALFRQVPAGEGQDETRVGVKYTVTNKQNYHGIPDITRERVQETVEKAKALFSQEGSAPKKSKKKNADVLRKALSQGFPEYPPLLLDHAFAVKELDPATPLDEVLQDEALLTKVVDVLEAAKVETDKLATEKSHPGYIVAKEDTRPPADSPAQGEEDAARKPGYLYEDFHPFKPKQFEGKPGVTILEYPSFNATVDEYFSSIETQKLESRLTEREETAKRKLEAVRQEHAKRIGALKEVQELHIRKAGAIEDNVYRVQEAMDAVNGLIAQGMDWVEIARLIEMEQGRGNPVANIIKLPLKLYENTITLMLGESGEEQDEGEDLFSDDESDSEDEQEEAAKAQKQSNNMLTIDIDLGLSPWANATQYYEQKKMAAVKEQKTTQSSTKALKSHEKKVTQDLKKGLKQEKQVLRPARKTFWFEKFLFFISSERYLVLGGRDAMQSEILYRRYLKKGDVFVHADLQGATPMIVKNRSNSPNAPIPPSTLSQAGNLCVATSSAWDSKAIMSAYWVTASQVSKTADAGGLLPTGEFLIKGEKNFLAPSQLVLGFGVMFQVSKESLRNHKLHRFDEPVATETPVEAQEADKEAEGKPNAQADEAADEENKDETEEPNGNNEDEQSAQEEPAEGEDEDESATSPQTQDDRQLSARERRMARKGRASELDGPAADGASVKSANSKQAPTRGKRGKAKKAAAKYADQDEEDRELALRLLGAKSAKAEKAAAEAEAKAKRQKEAEEAKKRRRAQHERAAEAERKRQALFEGGADDYDEETAAAEAADMEWIPALVGTPHPEDDILAAIPVCAPWAALGRYKYRIKLQPGTVKKGKAVKEIIGRWVAETTTGKVKKEHAEDAGIDRATAEKLRAKEGDLIKMWKDTEVINSVPVGKVRIMVGPAPSGGDKGKGKGGGVLWRKTPDRDSPHDRSFLCSVRGTNITCQSGSTPLSPYCSRFVRFASTAPATATMSPKASTRIASVRRLNNEGPGDRSLAEWWANERDNHTPEAAAIENAAQLLRTSDIPVAFPTETVYGLGADATRSDAVQGIYKAKQRPSDNPLIIHVDSLGMLERLLNPTQESPSRRTTTAKNAIPPIYDSVISRFWPGPLTILLPNPSGSPLAPEVTSKLTTFGVRMPSSPLARLLIHVTDRPLAAPSANASTKPSPTAAEHVFHDLEGRIELILDGGPCGVGVESTVVDGLSDPPAILRPGGIGIEELRTCAGWENVQVGYHDGTLDAKEAPRAPGMKYRHYSPKARVVLFEADSDEEAVAKHIRKDLEDSAVGAHMIGVVRTQHWKRGLGLLSADEMQKSLKRIPSLVDELVGFSVPVSDQVNGSTATKETFDCHLGTDVKSIAQGLFSALRAMDEMEVDVIYVEGVPDHQGDLAAAVMNRLRKAAGAELRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4T2</accession>
    <name>A0A8G1R4T2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_512663</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516419.1">
        <property type="nucleotide sequence ID" value="XM_025664668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4T2"/>
    <dbReference type="GeneID" id="37168070"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14447">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="6">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="466"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="7">
        <location>
            <begin position="712"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="802"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1041" mass="116480" checksum="642277AA5D3983D1" modified="2022-01-19" version="1">MRFGLNIHLHQVPEWAEHHVPYNRLKRLLKIAVEKATEEQSRPDFSEVQSCLDLSIAGHLRFRKEQESYLRKQAEEIQGHYRISLCNFDTATAYNLSRLDIEILCQSLSRLTKEISQLQRYQRLDVEAVSRIHTKINKYLGREKNRSAGRDDLDKFKEQNTSRKALARNLGLWIAHLQVALSDPSSRPVYPQSPLYEALRQDQPSIVVSMVDESLQQSKSSAKPFLFQLLELAVYELRPNTVYTLLFDVLPQNDIPLQAALLNRLFTVLGYRKMQLSAPYSCILFCKIRDLLSQVIGELGPRSEEVLLSEDTLGRFPLHYAASYGLLWECVAIFNVAKSWNKASQWCLIMHTDKRDCSPFEYAVVGNHRDAVSSVLVYLEKVLHASDKDDGIAPLFSRTLFTVLHYDYEDLIAVISQACSRFCRTPRNCEGASPLHVAARTGRADRFNKLLETVCASELNSLEPIYGWTPLVVACVEGHQSVVAVLLEHGADRDIKDHRGWTAQEHAAFRGHLALAKGMTGPSKWEPGTDVLTAASLAQQDDNFKALHQRPQLVVYLGSLQDGKQVNPFEFRTPSLKTIATGNDLALKVSSPGNDSARQMNISFLGDTANEPFIFELPTTGEAELRLELLDLGDGHDGQAELLGGGTALLIDNLNSFGENRESLVRERSIPILESGSFQAIATVTFTFLIIKPFQHPSIPSVRECFLRHDDFCLVGHRGFGQNVAGHDYLQLGENTVESFLSAASLGASFVEVITPDAQLTRDLVPVAYHDFSLSESGTDVPVHDVTLDQFLHASKIQSPMGHPTSIMGSRHHHKNSRSRSLTRGYEQGAQQMQERMRHTVDYMSKGIKPNTRGHVIQDSFATIEELLTQLPENLGFNVEIKYPRIHEATEAGVAPVAIEINIFVDKILEKVFTLGNSRNIILSSFTPEICILLAFKQQTIQSFTDREKRAGSLQAAVRFAQQWGLNGIVLASETLIICPRLIGYVQRSGLVCGSYGPLNNIPENAQLQVDAGINILMADRVGLIAKALEDRDGDDRRLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5W2</accession>
    <name>A0A8G1R5W2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_416342</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518593.1">
        <property type="nucleotide sequence ID" value="XM_025657727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5W2"/>
    <dbReference type="GeneID" id="37161129"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF72">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="17"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="485"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="497"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH60671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="526" mass="58841" checksum="B8C865E858CDBFEC" modified="2022-01-19" version="1">MPKLNLFGTGFVLQAAIWAACGMAFILFGYDQGVFSGIVENDDFLATMNHPNDSLEGIIVSIYNLGCFAGCIVNFLLGDWLGRRRAMWFAMVWVIIGATLQCSAFSVPHMMVGRFVTGIGTGVETSTVPMYQAELCEASKRGKLVCSEPLLVGVGIVISYFFDYGMSYVGGQIAWRLPIACQMIFAFVVIVLVFGLPESPRYCYKEGRNEEALQILSDVYGRPKDDPKILAEQEEILEAISVETKYGEYKWRNVFKRDEVSTGHRVLLAYGMQFMNQMGGINMVVYYIPTVLNTNVGLDKNLSNLLGGCVQIMFVVGSIFPTFFVDRVGRRAPMIWGSFGLGICMMMVSILLSFKGHANEHATSSAAVAFFFVYMLIFGASVNCIPWCYVPEILPLHARAKGTAVGISSNWIWNFFVVMITPIIINRLQWKAYLIFMCLNFAFVPLIYFCYPETAKLTLEEIDYLFTTPGKNAVQMSKELVKQRKQYGHVPGQRLTRHTDETGSENMEKKQDSVVAGVSDEQVEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R659</accession>
    <name>A0A8G1R659_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_475693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518156.1">
        <property type="nucleotide sequence ID" value="XM_025662742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R659"/>
    <dbReference type="GeneID" id="37166144"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034105874" evidence="1">
        <location>
            <begin position="20"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="100" mass="10709" checksum="1AA28F8E1DE30CE0" modified="2022-01-19" version="1">MHLKSILLTLAASTTLVAAGSDYYCLMAQDGTGMIQSPYCCDSFSPTPGDSIAQQGENCQSMDGYEWVDQCPQGGTVKCCYTIGPEFICTAEAEQNTDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6P5</accession>
    <name>A0A8G1R6P5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_446827</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>pyruvate + H(+) = acetaldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:45484"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518210.1">
        <property type="nucleotide sequence ID" value="XM_025659591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6P5"/>
    <dbReference type="GeneID" id="37162993"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000025">
        <property type="entry name" value="Pyruvate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="17">
        <location>
            <begin position="15"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="15">
        <location>
            <begin position="211"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="16">
        <location>
            <begin position="409"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH60288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="569" mass="62571" checksum="25D6AC82CB1D32FA" modified="2022-01-19" version="1">MATDIATRDLRKPITVAEYLFRRLHEVGVRSVHGVPGDYNLAALDYLPKCGLHWVGNCNELNAGYAADGYARVNGIGALITTFGVGELSALNAIAGSYSEFVPIVHIVGQPNTKSQKDGMLLHHTLGNGDFNVFAKMSAGISCTLGRLNETLEAATLIDNAIRECWIRSRPVYISLPTDMITKQIEGDRLDKPLDLSLPTNDPEKEDYVVDVVLKYLHAAKKPVILVDACAIRHRVLDEVHDLMEASGLPTFVAPMGKGAVDETRPNYGGVYAGTGSNAGVREQVESSDLILSIGAIKSDFNTSGFSYHIGQLNTIDFHSTYVRVRYSEYPEINMKGVLRKVIQRMGAVNAAPVPHLSNTLPESEKSSSNQEITHDWLWPNVGQWLKENDIVITETGTANFGIWETRFPANVTAISQVLWGSIGYSVGACQGAALAAKELGNRRTVLFVGDGSLQLTVQELSTMIRNNLNPIIFVICNNGYTIERYIHGWDESYNDIQPWDIEGLPRAFGAKDKYTGYKVKTRDELRQLFANQEFASAPHLQLVELHMPRDDAPAALKITAEAAATRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6T0</accession>
    <name>A0A8G1R6T0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium and cobalt transport protein and translocase of inner mitochondrial membrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_448774</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516677.1">
        <property type="nucleotide sequence ID" value="XM_025660013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6T0"/>
    <dbReference type="GeneID" id="37163415"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF55">
        <property type="entry name" value="MAGNESIUM TRANSPORTER ALR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH58755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="363" mass="40807" checksum="3B4E7A7F94FDB796" modified="2022-01-19" version="1">MDAKGLHRFSHFSCRTQQVVTSSTWEGLLIEQSTLSADTKGLEPDTWWVDICDATEEEVSTVCQALSIHPLTAEDIATREPREKIEAFRNYYLISFQTLLPTDDLKSSRSLKPSSSIPGSSGFYILVFKNATVTFSPSGCHHIARVRDRIRRTQDTHLVSSDWICYALIDEIIDDFEPYMRAAEREADAIEDQVFIARVDDVKALIPQLDSLRKSITQLIRCLTGKYDVLNGFVKRCQAKDRNPMFPDGDLLVYLGDVQDHLVTTLTSLSHFDEIVGRSQSNFLAQLSVNNIRLSYDVNAVLSKVTILATIFVPLHMVTGLFGMNVEVPGQNVENLGWFFGIIGCMCAFVVVCCLLAKRLRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R738</accession>
    <name>A0A8G1R738_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucuronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_457519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518636.1">
        <property type="nucleotide sequence ID" value="XM_025661525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R738"/>
    <dbReference type="GeneID" id="37164927"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034591661" evidence="1">
        <location>
            <begin position="25"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="423"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="544" mass="59336" checksum="C457279A1ADBC405" modified="2022-01-19" version="1">MHHRPITLLSLLLNLLGAAHSIAARPTFQDERSTSSSISLSASVPDDAALPVLHPFVSFSIEFAFFPDFAGNLSHPNLFSNHLLDSLAELQGAKPYIRVGGNTQDFALYDPNLRAATNATYITSISTDYPLILSFGPAFFESYFTWPGTNFIHGFNLGKNSSTDIELMLESVPVACKALEEGKLAYWELGNEPDLYKTSAQGIRRPANWTEQDYVNEWLNKTARIEKRLVEACPELADSKYIAPSFAGVTNSLNPVVTWEKGLDNSRNIALNSEHNYIGGATQPGVTLQNTLMNHTKTVESVAQQVNVSRILLNDNLTPGIPYILGETNSLYNQGAPGLSNSFGAALWGVDFNLYCASQNIRRTHMHQGSNYNYISWQPVGTNRTSIGTKAPYYGNAMVAAMLHGGDDVRIVNLPLAADTEAAYAAYVNDSLVRVAVINLVEFNYTSTDSIAEEVESRPSAKYTFQLPSSGSVYSDSVSVQRLMANGSNAITGITWDGWSYNYELAQGKPVRLQNVTIGEAISVGDDGVVEIEIPYSSAAILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R794</accession>
    <name>A0A8G1R794_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent protein hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_413965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518726.1">
        <property type="nucleotide sequence ID" value="XM_025657626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R794"/>
    <dbReference type="GeneID" id="37161028"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="372" mass="40923" checksum="6341A6A028095B18" modified="2022-01-19" version="1">MLRWRRFFTMAETAAKKVKTSSPLIGTHNGHFHADEALAVYLLRLLPTYSSSPLLRTRDPAQLATCHTVVDVGGEYDAASNRYDHHQRTFATTFPNHNTKLSSAGLVYMHFGRAIIAQHTSLPVDHEDVTLLYEKLYTDFIEAIDANDNGVSVYDPAAVSAANIQKRFKDGGITITSVVGDMNNPDPTCPPGEPQDEDSLFARASTFIGNVFARKLHHAVSSWLPARTTVGAAYRSRRDVHPSGRIIVLPQGGVPWKEHLYNFEKEASGSEETNPDEEAYYVLYPESAAEDSKWRVQCVSVNEGSFVSRKPLPEVWRGVRDADLDGVMAAEAERSGKPKVPEGAVFVHASGFIGGHQTKEGALAMATRGLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R813</accession>
    <name>A0A8G1R813_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Muramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_518279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517367.1">
        <property type="nucleotide sequence ID" value="XM_025664959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R813"/>
    <dbReference type="GeneID" id="37168361"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="281" mass="32749" checksum="8A6092C7E526A441" modified="2022-01-19" version="1">MIARSVLRRPHFRSNIPSFLRLRRLIRSPAPQIRLAHITPPFIPSTLFSTQLASRQDPSKRAPEIESGMDDADELERLLNKDGFKLWGFVIYRCTYQSDSDWEKLMIRFHKRVKKYLQYYNGLDLLARFTPTVLEDRSFEGTTVASLRDKFNEWAVTAVKEEQEIVASHLWHLKNGRYRFFIMVDQEALDSILSTPDNDIHGGFVRLVNAEWKAEELDEEKLAERGGPGPEEEPLEGCTEEDVGWMKVCWGESQTPGYVILDDSLRWDRYYSRPPVIQRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8K4</accession>
    <name>A0A8G1R8K4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_125068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519988.1">
        <property type="nucleotide sequence ID" value="XM_025653946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8K4"/>
    <dbReference type="GeneID" id="37157348"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="70" mass="7826" checksum="37D390E8369C2F74" modified="2022-01-19" version="1">MTSLPRDRPASLYLLPRISSFTLHAYAVNNSTPSLTFWPTLGFVRPLLSSPTNLNCLGKPWAQPNSSFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8Q1</accession>
    <name>A0A8G1R8Q1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_444992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519476.1">
        <property type="nucleotide sequence ID" value="XM_025659158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8Q1"/>
    <dbReference type="GeneID" id="37162560"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="54"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH61554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="207" mass="23206" checksum="6DDDD173EB52D117" modified="2022-01-19" version="1">MSDPKYAGSKLLSRGPLDPKDAKWTRLVMSSYTDPNGVERTWESAERQTRPANCEIDGVGIVTILNKETGPELLLQKQYRPPIDKVVIEVPAGLIDPNETVEECAVRELKEETGYVGVAEQTSSVMYNDPGFCNTNLNMVHVRVDMSLPENQNPKPQLEDNEFIECFTVPLSSLFEDMKKLEREGYAIDARVGTIAEGIELAKRFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8S2</accession>
    <name>A0A8G1R8S2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Avl9 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_364737</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519184.1">
        <property type="nucleotide sequence ID" value="XM_025655712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8S2"/>
    <dbReference type="GeneID" id="37159114"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="10"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="514"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="599"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="773"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH61262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="788" mass="88037" checksum="A1B0C021BDD806F4" modified="2022-01-19" version="1">MSCVRSGQDPIVMVIDFHHARGPEIELCVGDDGSDPAAENDWSLLPFMALSDGAHMSTEEFSYFTVRRKETPTEPATSLFGISCSRQIDSNLLIYRPPDVTRSTVQKAVVVVTDNPRSLGQLMEKLSVVTSAWFAQRDFSDIDILKKFREGLVISLRKDEGSKDQNLGLSLREMIHEFKYQTLVLFKALLLQPKMLFFGSRCERLCMIQFSLVSLIPGLLNKLQDCADPAFDTYAQTVEQPTSLKTSDRNSLLAYMGLPLQIFGKGSMFGPYTPLQQLDLLADYGTKSYVVGSTNSLLLQQKDRYSDILVNLDEDTINISSPTLRNALALSVADRRWIDLLTQIINDTWDEAHPEQPKTHGYMGSEEFIRLQFEEYLLALLACMQYHEELNSLNADELGRRSRAHLEAFNIEGDPALEFNSEFLAQWRNTPNYSLFKRLTSDALLFSIVEPRHPCAGGLTIDDVQRRLSQQVAELHLDERVRESREALNRHISTGQKKVSAAFNSFWADIESMREAQRKKNEEKASQSQRSSLDKGSRNSPPFSPSDTASVHSTSGASWFSARKAPAVDLTQAQASVSAASQKAGAYLSSWGSWASEKRKEWQEKKTTPASPTSVNSPSAPALNSITEASEADRGRRRSMQSRRSEDSTISRSGSRRKRWSNILLRRESGEFSSAYRKDDESSNNGEQDTYSRSPLSRTASSVHDDEVPAIESTEPPIEPTTHSAPEINEPAPTTAAEHTNKSPPDEAETSKLKSLEDEAKAPTTTHLQPSPDIKEMSPEPIEPHAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9S7</accession>
    <name>A0A8G1R9S7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_120728</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:79699"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:79700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:56312"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:140372"/>
            <dbReference type="ChEBI" id="CHEBI:140374"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:56313"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:22385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>6-diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:79703"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:230534"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:79704"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein-tyrosine phosphatase family. Atypical dual-specificity phosphatase Siw14-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="2"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519830.1">
        <property type="nucleotide sequence ID" value="XM_025653906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9S7"/>
    <dbReference type="GeneID" id="37157308"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052840">
        <property type="term" value="F:inositol diphosphate tetrakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18538">
        <property type="entry name" value="PFA-DSP_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000035">
        <property type="entry name" value="Tyrosine phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF48">
        <property type="entry name" value="INOSITOL PHOSPHATASE SIW14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="11">
        <location>
            <begin position="38"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH61908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="223" mass="25177" checksum="F819D123E86CD97B" modified="2022-01-19" version="1">MACPLTEKNSNSSLKSTNARHKASSVESESVQSELPVNFGEVVKGIYRSSFPYPWNLAALKKLGLKTIITLVDEPYPPSHVMFVKENGIAHHRILVQANKDPNVKIPDSVMCRILELLLDKTNHPVLVHCNKGKHRTGCVVACFRKLQGWDSCDVIDEYLRYAFPKPRLLDENYIDRFDPSQLHQLAQSSGVKTWQSSGLFKMPPEEQDRDKDSPNCHVPPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9U3</accession>
    <name>A0A8G1R9U3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4419 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_448294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517317.1">
        <property type="nucleotide sequence ID" value="XM_025659903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9U3"/>
    <dbReference type="GeneID" id="37163305"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025533">
        <property type="entry name" value="DUF4419"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252:SF11">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14388">
        <property type="entry name" value="DUF4419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40888" checksum="6313AA1B92B65AE3" modified="2022-01-19" version="1">MPVTLTTSNTRPEVWGTAKALTAEDLLQESCPENARRCKQLLQSSFTSQHLAENHISPSSNGLVHAVFQAYSYHHHLTLRPEDVWFAILSQLSFYINEHAEELRSHFVAHKGKEEVSVTTVGTISSVDFGALVVRMTEAIQKKVVDPDLRTWLMPAFSTTTASDQVIAAVLIMGAMQQYFSYKAYLMCGNPTVTLLGEREDWVQLLSKLEKLPDLGTEPAQFARLLRPILTRFIISFDDPTSESIREFWGLCADRISFGSGPSYLSGWVTAFCYWDEKGRPMEDKGISGCELDGVQYHRVDITDIPGAFASVPMKVNDNGTEYETELVAGVIGIHASCVGDAGGQQDMIQPASGWWIYEKEPAAENPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBC3</accession>
    <name>A0A8G1RBC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_456843</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519227.1">
        <property type="nucleotide sequence ID" value="XM_025661477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBC3"/>
    <dbReference type="GeneID" id="37164879"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="217"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH61305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="404" mass="43353" checksum="7AB9DBDC4560025E" modified="2022-01-19" version="1">MSNLPSHASPTFVAQDAPPHPVEELSISTDQATILPSDSRVDELRDNAIAQSDSADSDRGDVTPAVPASLLSPSFTPPATPGGTFNPAKLLQQTQKLSHTKAPKLLPCLPEVECIVRARIPTTTGAEMFLHLYHNNLDNKEHLAIVFGNTIRSRSLDKVRPGETEMDRMIRGAYVGTLHPGRVSSWYDDGNAEGAAGDGGPVSSERSTATESSPSQAPLVRIHSECYTGETAWSARCDCGEQLDEAARLMSFPMETLSEMASQQAVPVPSNASGGVIVYLRQEGRGIGLGEKLKAYNLQDLGSDTVEANLLLRHPADARSYGLATAILVDLGLGVDANPHGIRLLTNNPDKVRAIEGANREVAVKERVPMIPLAWRSGGKQGIKSLEVEGYLRTKIAKMGHMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBD9</accession>
    <name>A0A8G1RBD9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stress response protein rds1p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_495535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521488.1">
        <property type="nucleotide sequence ID" value="XM_025663937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBD9"/>
    <dbReference type="GeneID" id="37167339"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034440608" description="Stress response protein rds1p" evidence="1">
        <location>
            <begin position="19"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="37967" checksum="BF1F296D8C2E9B7D" modified="2022-01-19" version="1">MLSHKVLSLASLIGLSLALPKARSPKLDPNPVPGESPLFATYTGKPTPIPANWTRVIPATASGPAGPDDLLFQNLLSAEWIIYSFYQQGVEAFTPSSFSDLGYPNSTYDRIAEIRDNEAGHIRIFQDEISSTSLKPGPCNYSFGFDNDPETFLALQVYIEVNSMAFLTGLVRESNTIDTSSALVAVAEVETRHNVWSLIDIWDVSPFAGPADTVYPYANQILALTNSFVVSGSCPSENPEYPYPNQNLPEIGFVTNTTTGHPGSKIQLEFSNDPGFTEGGDYYAVFFHGVLSISVPFDIKTNETVVPGEFDKGAGIIALAVADEAGAPTEDSVLAGPLLLLQQPEKLTLLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBF0</accession>
    <name>A0A8G1RBF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Terpenoid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_455560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521503.1">
        <property type="nucleotide sequence ID" value="XM_025661393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBF0"/>
    <dbReference type="GeneID" id="37164795"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="61264" checksum="0890F7793D035136" modified="2022-01-19" version="1">MGNVIAKPARKIEVSFYLSWVNIWPSMPDSNPDEDTTNLTVPEQAEVFLRESSSPLPSYSLLRRVASSFRRSLTNGQIPLGGVDAPSCSETNLASGDYNPNSDCTCNGLYPVPHDAGIDSIMEQANCTAIHNTHQALQTVLKRKSEWNTTSLFSPRNLIEAVTELLLANADVRDPPTTCQGPAEVTNLHKIRAPDRRPSPQNDTVDVIHRQLYPAAEDVKFCTDAKYYFVLGAIHSDPAHDGLIRAIADAGNDILIADYCEVADAATLKLLQQSGAAAVAFPKLCVLLGIFSEWSFENMMASVLHFRVLGYYRDHARSRLPSGVYGSRMTSLTAHRYVDLGIFFAVASTSVWTKEQVNEAEFTLLNIVCTFINDMVDLRSDTARKQRENIVLRGVRGDLCEYLDQMMFECIETATLAVQTNPTCAYVLMAFCNWAVMSSHHKVYEISTQVSEVGKQDECLSRSRDHQRAYWGLLEVLAPYGTLGKEGPRVGQTRAELDFRYGVCRSSSTLHAAWLADITRSLLEPRTLRRIVDVVHFEWTGCEGEVEYCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBH0</accession>
    <name>A0A8G1RBH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_434104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521533.1">
        <property type="nucleotide sequence ID" value="XM_025658449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBH0"/>
    <dbReference type="GeneID" id="37161851"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="43167" checksum="D2C7FEF7A7F52973" modified="2022-01-19" version="1">MATEDDNFDIDIYGDGGGYNANEQGPEDEMKHDDTELILDAPEPTQQQQQQNGNPNHQGDGSSDGTVKPDSEGGAPHSDPVTQAGSANPQSAAKETPTPQQGTKRKEHDDRPTDPDATPALLISDLYWWTTDDDIRGWVCQADCEDELKDVTFSEHKVNGKSKGQAFLEFTTLQAATATKHKIESFSAGGQTRKHMVTYTSPQPNPFRTLPKDAPMRKDNQARSMSGGFNSPNPNMNFGGGMNNMGGGGGYRGGRGGYNNRGGMSGGMGGGNFGGNRNFQNPMGGFQGPMVGGGFQGNPMGMQNYGGFNNRGGMMGGMRGGPGGMRGRGGGMAGPNMMGMPGMNPMGGMGMNAMPGAMNPMMGGMAGNMGMQGQGGFQGPNPAFNQGFFPPNQGVGDGSWNPHGAKRSRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBL6</accession>
    <name>A0A8G1RBL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate-binding module family 18 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_515721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521096.1">
        <property type="nucleotide sequence ID" value="XM_025664799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBL6"/>
    <dbReference type="GeneID" id="37168201"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF16">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034407418" description="Carbohydrate-binding module family 18 protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="240"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="395"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="5">
        <location>
            <begin position="464"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH63174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="70241" checksum="9BD71EB181C7ADCC" modified="2022-01-19" version="1">MGYFQFIVAFSSLSFSVQGTLGHSLRGHSHYSHSHLHWHQARDSDASSFQLVPSQAFSSSNLTQSCQDALYAALECDSYVSKLGEPVWHGSLENTSLTDTVCSTECGLSLLTLHDQVVAQCGTDATIAQGIPALSVIDSVWTGWNETCLKSANGTYCNDIIDSWDSASDLSDVPRSDICDECWIRKLKMMQRSPYSAYNEPYETMLNYSVSVCNLTGVETEPTSGGIAIPAADPTCSTDTWYTVQKGDTCDSIAIAHSFSSSTLYQINPTLYNCSDPTVGLDLCLPLACEYIYQVTAADNCSTIAATIGTPWMKLVAYNGMIESDCSNIADTALLGGVRCVSPPGGAFNLTVSSNSSSESGIDGQGGSGSGYGTSFVALPNDVTLADGTTTDCGQYYTVVSGDSCVSVLAQANTPFNLFMAANPSISSASTCDGELKVGVTYCIHPMSGFNATDINGNLTISTNGLCGNGTTCLGSSFGDCCSISGYCGSTADYCTAGLCDSSYGLCVSGNPVSLDGLFSLGLVARLMDIVVIHPTTLPTSHVRVLSEVVRKHPRSALMAYAVPSLRSTPPARVVHSGTVVRLTDIVGARRTTVLILAVKQHLAHVILDLSSVRMACVEHFLLMQHVRVALSETAVQSMATVEALTITAGLTPVTPHLALVILLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBM7</accession>
    <name>A0A8G1RBM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_366821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518247.1">
        <property type="nucleotide sequence ID" value="XM_025655795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBM7"/>
    <dbReference type="GeneID" id="37159197"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF6">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="252"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH60325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="498" mass="55053" checksum="9436810AD0B66FAF" modified="2022-01-19" version="1">MPFYSSSTRSKKSKKDGTSRASTASVISSNSHSTKGPKLSVEKPKVDSQTQSTISKSNSNGSTARPQAAQNKHDSDRKAPNVFEYLEDNSTTTDDSSDDEYEHHVPSNNAKGAYKNAVRQMYRPAAQGTDARSRTSSILSKSSANSQKTPSSIDIPPSTVTSNTVKSHIPAHKPSLDGAYSGVGAFPDGSNYYEKRSVDLNARPETYYPQNSVSLQRSPLPPSPPRSPEEDLHRPTRRNRRNTKSSSDISGYSLLATRLSSATESQEPRLPPLYRRFENLNHRVLLHLQDEIAQMEEDLRLVDEYEELQRAATAEQEGTKMLPASRRMDAQAQVYSSVHYRREELLSALARKTEQYNNALSAYSRVLQTLPRASTQDINTYRNWMKQTNPVIAAETRFLDYTKDLLSLTPRMASTSTAKPIFTTIIIASTAILLPLLAFSMISEFSGRLVVVALVGVAASIIASTNSTSADQLVDSRDGWRCATIYFGFMTVAAMFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBP4</accession>
    <name>A0A8G1RBP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_415613</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518277.1">
        <property type="nucleotide sequence ID" value="XM_025657698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBP4"/>
    <dbReference type="GeneID" id="37161100"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH60355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="388" mass="43723" checksum="3B6D8FC490E46E58" modified="2022-01-19" version="1">MPRRTHKKSRNGCLECKRRHIKCDEKQPICSNCRSSERSCEYADPFIRAAHSRSSKSSTPSPAGLVTSEISLRSPAHPSSLSDSPPVNMLHAELFFNLVNYTLGSLSEGETGWLGAPEVMRMVVSTPYLINQMLAMSALHLSIVHPENGEWYRRHAAHLQTHALEIYNQRRLEVNQESNVPLFLFSCILGMHTLCDVLVHREETSFDTFIERFVRCLKLQMGIRVVISSTTWQSLRESILRKPLQDGAILFEWDTKLGPECAGLLRLVEGAKLGDSITSTYRGAIQALQMSMNAALKASLKNVVGVTGWPVIVSPEYAEHLAMQRPEALVILAHYAVILYWHRHLWLFGDGGRFLIESISRHLGPSWAEWLEWPNRSLSEPGRLGGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBT5</accession>
    <name>A0A8G1RBT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="14">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_13911</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="14"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520880.1">
        <property type="nucleotide sequence ID" value="XM_025654058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBT5"/>
    <dbReference type="GeneID" id="37157460"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="16">
        <location>
            <begin position="169"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="527"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH62958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="560" mass="64057" checksum="C759BFD7954734E5" modified="2022-01-19" version="1">MDRTIARAVTDKKPVPEIDFTLHVMEDGTQVSTMERVIKEVQAPALNTPPDDLFWSREDPSKPNLQFLKQHFYREGRLTEDQALWIIQAGTQLLRAEPNLLEMDAPITVCGDVHGQYYDLMKLFEVGGDPSETRYLFLGDYVDRGYFSIECVLYLWALKIWYPNTLWLLRGNHECRHLTDYFTFKLECKHKYSERIYEACIESFCSLPLAAVMNKQFLCIHGGLSPELHTLEDIKAIDRFREPPTHGLMCDILWADPLEDFGQEKTGDYFIHNSVRGCSYFFSYPAACAFLEKNNLLSIIRAHEAQDAGYRMYRKTRTTGFPSVMTIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCTPHPYWLPNFMDVFTWSLPFVGEKITDMLIAILNTCSKEELEDDTPTSVSPTAAPPSPPAAMDVESSEFKRRAIKNKILAIGRLSRVFQVLREESERVTELKTAAGGRLPAGTLMLGAEGIKQAITNFEDARKVDLQNERLPPSQEEVIRRSEEDRRIAFERAHHEAENDAGLATVARRISMSAGSGKTRRQRDATRDSREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC57</accession>
    <name>A0A8G1RC57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Crh-like protein</fullName>
            <ecNumber evidence="16">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO85DRAFT_387208</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="16"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521075.1">
        <property type="nucleotide sequence ID" value="XM_025656663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC57"/>
    <dbReference type="GeneID" id="37160065"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000159">
        <property type="entry name" value="Glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035002342" description="Crh-like protein" evidence="19">
        <location>
            <begin position="20"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="20">
        <location>
            <begin position="59"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="345"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="348"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="17">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RAH63153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="403" mass="43438" checksum="DE13E7DE20ABDD8D" modified="2022-01-19" version="1">MRHIPAWFVACLAAATASASAPACSTDSKCPEEYPCCYSGQCGVGTYCLGGCNPLESYSLDSCTPEPICKNQTYSFTSMDNAVLYDHYLGNASEYDWVYSGYPKIKNDSLWLTMPNGTTGSLYSLNHYIWYGKVSAKIKSSRTQGVVTGFILMSDDFDEIDLEWVGYNLSSAQTNFYFQGVENYTNEVNAAVSNGNTFDEWHTYTIDWKPDVLEWLIDGTVMRTLTKNSTYNATSGVYQYPQTPSRLEMSIWPGGSEAEGLGTIEWAGGLIDWDSTDIKEYGYFYAQYKDITIECYPAPAGTIDKGDTSYVYTSDSGLSDTIELSGNSTVLYNLQDTGLNMTAGTKMSDSATASGSSSGASSTGGSSSGDSSTKKSAASGYGERVMEGSVLAAVGAVVALSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCJ3</accession>
    <name>A0A8G1RCJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_411866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521621.1">
        <property type="nucleotide sequence ID" value="XM_025657546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCJ3"/>
    <dbReference type="GeneID" id="37160948"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007011">
        <property type="entry name" value="LEA_SMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04927">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP" evidence="2">
        <location>
            <begin position="74"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="SMP" evidence="2">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="169" mass="17820" checksum="D11C2460889B9E96" modified="2022-01-19" version="1">MSSEIPDIPELKRAVESGQRIDPEDVSALAQNESELTGGGPIRGGAAATAQSLAMKQMNFDEKLEALSRKPQSHITQEDARELHAAEGRAFNKAPGPGSVSAQVRSIADRNEALGVPAIPGDASVYITKDDAREAQHAESTIYGGKNPRGGIAAEMQSAADKTEHAYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD77</accession>
    <name>A0A8G1RD77_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_456279</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520217.1">
        <property type="nucleotide sequence ID" value="XM_025661432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD77"/>
    <dbReference type="GeneID" id="37164834"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="18"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH62295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="348" mass="39778" checksum="9537B897138FF667" modified="2022-01-19" version="1">MWLDDIGSRVGSQLSRPVTYVITSFLSIALYNVVELTFILLLTFKRRKGLYFWSFVVATWGIAVYSIGFILKDFNLVDNAISYFYVTLIVVGWCAMVTGQSMVLYSRLHLVVRHHIMLRFILGMIICDVFLLQIPTVILCYGANSSTSDRFVLPYAIYERIQVTVFFIQESIISGVYVYETFRLLRSEDEVLEGTHREAARRLMLHLILMNIIVICLDIAILVLEWAGRYAAQTAVKGFIYSVKLKLEFDILNQLVTFVYHSHTSNSGNLDVDSSSRNLWDMNQQTEPNTASARHLHPRHCAWASVASRVRRDFTISAEKKMSKIIQYARKQSDSSGSPQDQGSVRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD83</accession>
    <name>A0A8G1RD83_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="7">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_409633</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="7"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520501.1">
        <property type="nucleotide sequence ID" value="XM_025657442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD83"/>
    <dbReference type="GeneID" id="37160844"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002365">
        <property type="entry name" value="Terpene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF76">
        <property type="entry name" value="TERPENE CYCLASE_MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01074">
        <property type="entry name" value="TERPENE_SYNTHASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="9">
        <location>
            <begin position="91"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="8">
        <location>
            <begin position="396"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH62579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="735" mass="84968" checksum="D70A1FB2799E566E" modified="2022-01-19" version="1">MSGPHIGLWRTPAQGHLTPDANGDLKTDYTRWRLRDDRGRQTWHYLESDAENEQWPQSIADKYFLGLPTGLPELPKPQTPLQCAENGLEFFSKLQLEPGNWACEYGGPMFLLPVLIITYYVTNTPIPPEYATEIKRYLFARQHPEDGGWGLHIEAHSSVFGTCMNYVTLRLVGVSEEDPRMVKARGLLHRFGGAIYGPHWAKFSLAVLGVMDWECVNPVPPEIWLLPDWVPFAPWRWWVHIRQVFLPMSYLWSKRFSHPLDPLTKQLRQELYTQPYDSIDFAAHRNSIHKADNYYPKTWLLNTLNSLLVNIWNPYLRLPAIVRRAEEWTWELVRMEDENTDYAGLGPVSNPFNMIVCYEHDGPDSYSVRRHRERLHDYMWMKDEGMLMNGTNGVQVWDTAFITQSIVVAGFGDDPKWRPMLTKALEFLEDHQLRENVPDQEKCYRQHRKGAWPFSNKTQGYTVSDCTAEGLRSTIQLQEMHNFPKLISEERLKDSVDCLLLMQNPTGGFTEYETTRASEKVEWLNAAEVFGGIMIGYDYPECTTASVTALSLFSKYYPNYRAAEIKTAKEKAVRYIKRVQRADGSWYGSWGICFTYAAMFALESLASIGETYETSADSRRGCEFLISKQKEDGGWGESYLSSEKHVYVQHEKSQVVQTAWASLALMEAGYPHKEPLRKAMQLLMSRQQANGEWLQESIEGVFNQSCMISYPNYKLYWPIRALGLYARKFGNEELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDQ4</accession>
    <name>A0A8G1RDQ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_8928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520741.1">
        <property type="nucleotide sequence ID" value="XM_025665764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDQ4"/>
    <dbReference type="GeneID" id="37169166"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="92" mass="10509" checksum="1C42DC63CB71A5F3" modified="2022-01-19" version="1">MIPSRKARSGQSEPHSQPHHPPNLPFYGRPHPFSPPNQCAHSLSISRDPPAPRTMPVLPPFLPSLHSFLQNNFTRNELVSRYYYCSTLLLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDT6</accession>
    <name>A0A8G1RDT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_483242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521313.1">
        <property type="nucleotide sequence ID" value="XM_025663145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDT6"/>
    <dbReference type="GeneID" id="37166547"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="182" mass="20235" checksum="7152043FE1B82686" modified="2022-01-19" version="1">MFNPISKLVRRGDSESNDGLSPYMVDLLISLLVLILLGLALVGALLVLRRKRLNREQSELPVHNGQCVPNHRRFTVSASPNAKTESVLVYDEKRSLIENSSSPPPSPVPEIRITFPEEEDESGKRKSGRVVVVRITDAGGVGLEPCNEELPPYQSSDAERFQSLDIERMGGLKEKEATNRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VH06</accession>
    <name>A0A8G1VH06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_509809</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825094">
        <property type="protein sequence ID" value="RAH51742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509664.1">
        <property type="nucleotide sequence ID" value="XM_025664511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VH06"/>
    <dbReference type="GeneID" id="37167913"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="23"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH51742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="539" mass="58149" checksum="BD650794D604B8B6" modified="2022-01-19" version="1">MSSNSPDVVCRTHAVGSVKLYSILTGIMIATFLISLDVSIIATAIPSITTQFHATTDIGWYGATYPLTMCALQPISGKLSSLLSLRWTYLSFYGIFLLGSLICGVANSSKLFIIGRAVAGAGGSGVVSGGLSVIALITTPEQRPLFTGLVTSLYALGTVVAPIIGGALAEHTWRWCFLINLPAGAVTVVTLLLFFHPPQNTGTQGVSFLKQLDLIGCALFIPSVIMVMLALQWGGDEYSWNSATVVGLFVGFAVTMTIFICWECYMGDEAMVPVVLLWGRSTMFSIAFAFLFLGSFVIPVYYLPEWFQIVKSASPIRSGVMLLPSVCTQVFGSLVCGISAKHLRYYNPWLFVGSVFLCIANGLYTTFTASSSSASWIGYQIFQGLGCGFAAQIPLLTVQLVLKDRPRYIPVGIATVLFTQYFGSAVMQSIGGAIFQNELKKQLQVQASLDNKQIEMLLNAGTLRVREVAVQAFPDRLVDIINAYNKAITTIFYLPIAGSALAFILAAGIPWVNTRSAQEDDVDCIEEADQLQSDKSANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VI09</accession>
    <name>A0A8G1VI09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_463539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510699.1">
        <property type="nucleotide sequence ID" value="XM_025661933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VI09"/>
    <dbReference type="GeneID" id="37165335"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="172" mass="19228" checksum="AD0984772D94B901" modified="2022-01-19" version="1">MPGLRMGLGLDLPPASAFARGWRRGERESDGLIDEWRATLCLPELWLVRRVSNLYTVSPDYCPNFLLYGSHCHALAITRRAGGRQMVASSFVLLASMTVVPSGSLCKLSLTGTQIRQMGDFFCQPTCTFLIWVIWSVSVSRQFYPMDSDSLFIMICPFQNLSSAVYAAVYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VI39</accession>
    <name>A0A8G1VI39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stress responsive A/B barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_491312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
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    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH54049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="115" mass="13561" checksum="961E3019CE0346CC" modified="2022-01-19" version="1">MTIVHMVMFKFRSDVTAAHKETFARELKKLKDMDCVKGHRLVVGGPSMTDPIERSKGFEFALLSFHESLADLEKYQASKEHHWVTSTYMFPYKEDLVRFDFEVPPEDEYMFLFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIJ4</accession>
    <name>A0A8G1VIJ4_9EURO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BO85DRAFT_453130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="GeneID" id="37164393"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034637269" evidence="2">
        <location>
            <begin position="22"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="208" mass="23124" checksum="0606EC4A7CCD0CFB" modified="2022-01-19" version="1">MYRSLFSILIALCFYAHCAFASLTSSEIANSLNELAQQGFAAKDLVLEINSTADAGPMRDVYTEMDTMVTVVLTDVEFMTNTPIITDQSEEQTVYEGYSNFVQSLLELMDAFSDSATELKSIDSTTKEKVPSEVRILESAVDAYFYNIIGLFPANSSYNAQASNQKAQVDTHCFQAIWAFDLSDGSQSSSQSRRNNSLRARRMMRNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ31</accession>
    <name>A0A8G1VJ31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Orotidine 5'-phosphate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_443205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
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                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="37162270"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006222">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
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        <location>
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            <end position="391"/>
        </location>
    </feature>
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        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RAH52328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="444" mass="48469" checksum="3437B283531D2AB9" modified="2022-01-19" version="1">MDTFSSSDSPSFPGNRIVSYLRTLAKSKSELPYGLPVCVSPSHTVTNTDSLLHLASLVGPHISILQVHADIIDDWSEETVRQLTTLARKHGFLIWESGRILNSTVDVVGRQKSESREVRNGVVDLIRKKYTRGVVKPASWAGMSTAWASGAAVYNQEADILIPTLKAAAREAVADAVQTIRTEITADSFANEQSNSDQDSAQSQHLTEYVVDQSGLGLPPRKASTISLTQTITQHTEDSADYPLESPQFERHGFEFGTLSPSTIPEDLPPPPLLARGLVLCLPSRTDTSFTPDYRQSCIAAARANQDFVVGFLCGEPWHLASQRGDIFETGLSGYNDEQQQLSPYSSDDDEELPHFALFSPICQGGQPLDGSEEDEDMGEEDETPLPETTIPLESLNPLAAKLFYAAGKAFKLREATSQENGITHKSDTTKSCQILHIPIVSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJA4</accession>
    <name>A0A8G1VJA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BO85DRAFT_403927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512422.1">
        <property type="nucleotide sequence ID" value="XM_025657254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJA4"/>
    <dbReference type="GeneID" id="37160656"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="263" mass="29753" checksum="E39FAF1D90CD9B78" modified="2022-01-19" version="1">MKDMEFRLNYHVGTGEGGRDARYNVCQVLIDNRVPHAIWFEDALVHFDVPTAVFDLYILVEGIDAAANILAKAGWYFDVQAPHLIGNAEVDLLDFPQQRLISPDGETRTVLLPATDWKFPLTSNTRVEFVPLKVMPSLKVPFPPLAGFLDALIDSWLDCPSNDAMLLIVLACQISYLYTHAPALKQKSFAEEMKYEHRQFHFDVLAGMETGTLQFRQHQRGIRDALLRGQYTLRDCSASRDNKDLFDPFGGITFESAGKEEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJG7</accession>
    <name>A0A8G1VJG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_499300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513323.1">
        <property type="nucleotide sequence ID" value="XM_025664068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJG7"/>
    <dbReference type="GeneID" id="37167470"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH55401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="312" mass="35938" checksum="8DC9865DFA59A951" modified="2022-01-19" version="1">MQQQPDVYLESHKQVLKWTKELEFLGYILSEIVDPDGLEERGYYCHQAADLPAIVDTLKRACSQPNSRLRGVLGKQAAKYFSNLLKKSKQIRNVMAHHLLLSHEKLLALGKTKEELDQIFQSVISRAASRYNIQQVTWYPDDTEFSGIPNRHTETIALGGEPPLYQRQRILAFEAGPSNMPKKKKKKKQKEKATEESRVAQLIALEASLRRKLGKVQKEKAQIMEAKARKLQILEQTYRQRWQERMEKINRILLLTKHEERDLKVQRGKIFGEPFGANVSTDALFILLLLALSSPLWLSGLVVRKFGVQIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJT2</accession>
    <name>A0A8G1VJT2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tat pathway signal sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_451021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513698.1">
        <property type="nucleotide sequence ID" value="XM_025660502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJT2"/>
    <dbReference type="GeneID" id="37163904"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="2">
        <location>
            <begin position="126"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="406" mass="46002" checksum="8EE38D0697C9404B" modified="2022-01-19" version="1">MSEKTYKIWNHSFKWTSDHIPAEGLQSMRYSYDVLGEECYLRLKQIVSKPSHGPTEQAPLNPDLYTLLRDNYTQDKKLRKLWGQVHSIPDWVDWAQIERGQKVLYRYDILALNSLAFQGLIGAMGPGRGAETLARTSGLGRQTARRRILETAQFILEVTQSLSALQPGGTGQIACLRVRFLHAIVRTQFMALIQRDSSQSTYNVKEHGIPINDIDSIVTVLDLSAVILLIGLPAQGIYPSNQEVSDCIAMWRLVAHYMGTPSEPFKTPHSAKVMLESYLVAELHPTEKSGLLARNIFRALDDALPYVPRSLLMANTYWLNGSELSNQLGFEGTTRAWSLVLSLLYGVFVGLIYLCRLVPWLDEGHIKLQRRLQWYIIVEGKTGLGKRSTFKFKNKPQLQPPQSTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK23</accession>
    <name>A0A8G1VK23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_377455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513187.1">
        <property type="nucleotide sequence ID" value="XM_025656264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK23"/>
    <dbReference type="GeneID" id="37159666"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000084">
        <property type="entry name" value="Peptidase M38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="69"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="441" mass="47480" checksum="A13BA1F5FA0D2724" modified="2022-01-19" version="1">MSNNNNTSKPWLPRAAAPEIIFYNTNVVDVEAGDIIADAVVHIKNGRIVEVSTGDVATPPDAVNLNGQYICPGLIDCHVHITATPGSPSLKDMFSASPNTIAYRSTFVAREMLLRGFTTVRDTGGADYSLREAIEEGLVAGPRLFIAGKALSQTGGHGDLRANYQGSEYKCCGGHSPALARVCNGVPECLEAARDELRQGANFLKIMCGGGVATPSDALDMLQFTAEEIRAITTTARQSKTYVTAHAYTVEAIRHAVDNGVRGIEHGNFIDEETAAYCAELGVVFTPTLVTYYGMSKPPFDKFLDDFSQAKNRQVLDSGLEALSILHKAGAMICYGSDLLAGLHPLQNQEFSIRSSVLSAKDILKSATVNAARYLGMEGQLGCIKEGSIADMLILTSNPLEDITILDRIQHHLVAILKDGRIVSKNADWLSVDPLYNTSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VK83</accession>
    <name>A0A8G1VK83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_153300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511390.1">
        <property type="nucleotide sequence ID" value="XM_025654160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VK83"/>
    <dbReference type="GeneID" id="37157562"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16015">
        <property type="entry name" value="Promethin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="226" mass="24783" checksum="2C86B2D2C2516846" modified="2022-01-19" version="1">MSLSSATGNLAGRPPKLTNDLKSTVQQTQDTTTQTATQLSDSVLPGEFPGDSDHIHDAQRDDTNNGPVLAPLQQWCRQSLPRLLDRFEAYLAGLLSWILPAPRQAWLYDEAARRPASTTFLICQAICCGVPLLVFLAGVFVFAAVAILLWAILSVLILGPVLLVASMMGVSLWGWGWLLYGLVKWIDEKYLGGLISRFWLSRMPSPEGQDQESAEGQDGTQEKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKP0</accession>
    <name>A0A8G1VKP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_490059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513429.1">
        <property type="nucleotide sequence ID" value="XM_025663639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKP0"/>
    <dbReference type="GeneID" id="37167041"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH55507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="492" mass="55453" checksum="E4E33941D8BAFE17" modified="2022-01-19" version="1">MTARTHTPSFQPYTLTPLDHLLPPHHVFAYMSFRPEQPSEAVDAIDSGLSNLVSQWPFLAGNVAMVQKEKRRNVRELQPPTTSDLLQCPLLHVKHHQHTISDALASPVIDHEMLNVPKTLSNSNPIPAVRFQANVMQDGLILCLAWHHQVMDSLGVTIILHALARSCSERDQKSATPRRLPMDHDKEEQARRRINQAANTSNPDLKDAYCETSYEEIRGRQPDSIICRRYTMHTDRVNYLKNSCNNLAHELAKGHSTSQKISQSESQYKLESISSDDLVTALAWLSVSRARRRVASKHSSRLPRVSSLSRNIEVRSILQPPLPRSYLGNSLVLAKTQCEWKDIPTPQEAPPVTRKQMDKETINALLKLALMSRAKCKSIQDEQIRGLIGRVEECDDFSSVSGAPAEVIMSSLRKTDIYASDWGKKLGPLLDFDTIDGRTDGLTLILPDRNPARRGESNWEVRVNLPVEVMEEFGKDELLLWVTEAEKPGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM28</accession>
    <name>A0A8G1VM28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_520137</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515287.1">
        <property type="nucleotide sequence ID" value="XM_025665104.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37168506"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="4">
        <location>
            <begin position="82"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="301"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1025"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1104"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1186"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="217"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1059"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1104"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1125"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1212"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1242"/>
            <end position="1251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH57365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1560" mass="176851" checksum="7DF252A904B42DDD" modified="2022-01-19" version="1">MPEDFSENVGGTGSTAFARALEEYINKPRSARSKTPHFLKKLQEQQRSGANLTGDAVKKDLFLLDRQATDRTAARAARKILGPVIQVLNTYSGIVETLVSADPMPTAIIWGCLKSVIDCSQRFLELYEKISDQIKRLNTHITVLTEYEDLFDHSATMRELLQASYIDIIRFWRRVDKECNRCVANRAFRAIAPFSTEKLDGIITSIGDTADSMSRLIPAVQERLDRGERENAAEERRLAGIAREEQAALIQMYAEEMEKRKEERRLQRQEEVRKWLRDGTMPLNGSNFRHRDSKLAQRSPGTCDWVFEHATLKDWMNKDSPASQIWVKASPGAGKTVLTASAVEKLEATSAENAAVIYHYFTFDEEFPALLVYRCLAEQLVNRLGKQTGDVPKDIHKFTQEGATTANVEDVKQVIRMLLEEMAITYIFLDGLDEECETENRKKELCKVLEFFGELSRAMPSRLRIWYSSQHRTCLDAALSSLPSIEITKDLNSHDIEHYLLDKIEDLKSLEFDAGYIRLIIGDLREKADGCFLWASLMLDSMSDAVTLHKVQSIIEEGLPDSYEKYYQRKMDSIRPGLKEFVSIILSCIVHAKRPLRLDELCECTAMVKGIEGQNIDRSQKIKKSKVLELCQPLVQIHESDGPAGTISICTLTHGSVKNFLLKNPGILANNSNPPAYALTNDVLANVCLKYFLQPRYQQLLTREGETFVDCDGEDILNHHLLSYAAKYWDKHLDGVNYSLDYCQKASSFIRSPQFFTLLQVQSLFVDGQFRFWYSTYRPWAGRHIKRVFPHWLDDNCNEPFAKDYASFVGEWGPLLDRETSITGAFAGEIDRCFPGALGPNNYLHKGPSRYRSLMFTAETEPTEPPIRCFEGVDETGRYLTVLNLEKVSEDGLQFCCEHWHLNGRKPELQRTQKLYASASTWSLYEYPLTENVLGRPRLVSFTKDLKFIRIGSQLFVKGVDHDYTSLPVTDPDEDYFDEMASNNHMVAVSTRRQISKSDVEIPGAVTGDVRIVDYADIAIQKREEEVSELDQRSTAAPTSTADTQPTPTVTKSSDDDSNSGTIDTDITSESSLKLEDPDEFQPSTEKDKALELATKVSNYTDELMKSSSESAGNSAYTSWSEGSTDLDDEMEDEEQWNDWDLEHLELEELDVEEKGSFLGSDNDGYSSGDERKDALELHDDLASELSESDNASDALEKRSDMLPLDSDGSDVESVGSSTNYSVSSSEYGSDDENRGILENMMTGNKTTSTEGTRRTSIRVYDATRKERIPVFHFTCFIKDRLFDSPPVFHPSKPLLVWPLGDREILFANYEKNTYFTRGLCRSGYGSCHIFIKAHFSSDGRHLHLAALEAREAAKSDKEEASVLLSLQVSTHRLSEHKTASSPPRMIFRTTVELGNTPKLSVSNLPHFLTWSDTHLFFTSRNNKLDVLRIPLFRPPGDNVDLNICSLQEPIFLPRSVEARNMYFFPSQETTKKTLRKKDMKSTTLILGAQTCLPSQGILVPRHMCYPPIAVFLREDKDLVWACRSSVDEGRKINNACGRLRGKFESFDHNEDCDIIPYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMF4</accession>
    <name>A0A8G1VMF4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_448789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516711.1">
        <property type="nucleotide sequence ID" value="XM_025660021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMF4"/>
    <dbReference type="GeneID" id="37163423"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="59" mass="6996" checksum="DA5572E8211DECD9" modified="2022-01-19" version="1">MIESTTFVKSHVLHHLHARISLQEQGYLLHETTEYDHHQIVTITPPFTSRCKQNQERDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMK5</accession>
    <name>A0A8G1VMK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB/POZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_437939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516728.1">
        <property type="nucleotide sequence ID" value="XM_025658649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMK5"/>
    <dbReference type="GeneID" id="37162051"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="30"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="241" mass="27886" checksum="1CA411F86B423116" modified="2022-01-19" version="1">MHWFALLKSMATNPSTLLAILSNIRNGIYSDFEIKCHPSTFNVHRCIVCPQSPFFEKALCGEFQEAKTKVVTIHDDPTIISKMIDYFYRGDYDETPDKKHPANNPEYETPTTKAHVSIAMYNVADKYAVEPLMALAKKKLENRLTLAWSNKEFLRIIEKVYGPDSPPNSKLRDTVASFAVEHIATLKEIPAFRETRMEYPQFSYDFATFLIERLSRVDRKIRKRSALWLTLGRQDHDNLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMW4</accession>
    <name>A0A8G1VMW4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Cytochrome b mRNA-processing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_448076</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the CBP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517058.1">
        <property type="nucleotide sequence ID" value="XM_025659861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMW4"/>
    <dbReference type="SMR" id="A0A8G1VMW4"/>
    <dbReference type="GeneID" id="37163263"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012420">
        <property type="entry name" value="Cbp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07960">
        <property type="entry name" value="CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH59136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="116" mass="13770" checksum="D5CDE61F2C415A97" modified="2022-01-19" version="1">MSRAGTWMKMLGVGIVICVGGPAFVQYIRPTDEELFKRYNPDLQKRSLEEGDRRAREFDEYVTRLKQWSKSDKSIWYAAQEQQEQKRVEAEVQRNQARDDAKVQREEMRKELLGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN25</accession>
    <name>A0A8G1VN25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cullin-4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_424308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514210.1">
        <property type="nucleotide sequence ID" value="XM_025658038.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37161440"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000006">
        <property type="entry name" value="Cullin-4 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000049">
        <property type="entry name" value="Putative ubiquitin ligase subunit CulD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000031">
        <property type="entry name" value="Ubiquitin ligase subunit CulD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000035">
        <property type="entry name" value="Ubiquitin ligase subunit CulD, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000044">
        <property type="entry name" value="Ubiquitin ligase subunit CulD, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="2169"/>
            <end position="2412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1654"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1699"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1756"/>
            <end position="1783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2539" mass="285423" checksum="0044503972F895FB" modified="2022-01-19" version="1">MEERDAATGLRGLYQDLSALSASSFVNIERLRVELEAHIDDFKKLLDKPPKNNTSRQAVLSGKITVDDLEYSINEEFQQGALMLADALNLDELQAAMLFMAAQEDAHILDRPPVIAAIMRFHERRQFLLDSLRLIFQESFEVEREMTQVLMQEMLAFVVEIKDGPLRNASLYTRKCMKSMEDIENWLVLLNEQTQKASIVGQSAEYDIVEALEYQRSSLQQQHESLGAVLCYLFKGPYTSSEDLRLLLNHLRKLERFDGLLIHYLPCIIASFVQHGSPESSSSYRDARSLHTAITSSKDVQPWKIPTFHSAVIALWLAVYSGWDFDGPASPLQGVDMEKDSEERTKMFMTALDDGGLELILAVCYGVNDEEWADPARSELVTLLLKESASATLETDSCSDFLKVLLMENFEAFAEACIANMPDAVRMLKTEEDSQRLDHLTALRDGLTSSLHHGPVEARTHLESFLMIMAFAFEHRPDSAQEFWADPDGNLYGFLQWASKRQTVPRVSAFCELLCSISVGEDNATAAHRFLSEEDKFMSAKFKRSTSMNWSQMFAELQLYATRVTEKPSTSQAILRSRKLDPADMSEPESPVMLTCYLRLLEHLSKQSATIRDWLLHHPTFNVVGTLLTLCSGPIPTHLRANVFAALAALMTDRTSHNGNEMWLAIDQWISGGSMSASNLGKVPVVSNPLVWHEQQAFQRIGESFDQANAFVRLVYSLISPALDSADFHLSLPFPESLGSSYRMPGIEPYIDFVMGQALSRKIPDLNERQTRFLTYNCLDFIVTCLQSFNESLVSVLSQPTISTDSIIKQSTFVTYIRLHPFARVTEWLFNEDVIKSIFATAHQDVNEVAKASSDSVLVQSLVRSLEVMDMMIDLQSTYFNIVRPAIKAQTGTSRTNVANSALSAFEDSILNNLSIIPALCLYCSTGHQQLTVTSMALLEKLSSSRKLNKITSPELSKWRSPNKIVEVLSAEVDLNSVSRPLVSQMQPESREIESGPQSPGYIIRESLLALLNSCLGTINDRPTIAHLLLGFNSIGNILDIAPDSLFADKMSLLHAVIGFLQNYPDELDGNILPWLVHVKRMAFGVLKHLWSSKLSSYFTLAEMRGSRFLLSMFASQPIIGPNTPWDGFLIGTPEFWLSESTAALAEFLLYRSYLFDYAATEIRSATKLGSPTLQAEIISTLFGNSVSETGETIVNPSIFDMFDFADLDTQHQLQPPALTFLDGLEFDLCARPETDSSPIVYNLDEIVELVQVRKEELSLSGHLRPQDEELFQAESESLILFVRSTNQASQIAFNRYLALRSWTQLITTMLTCSEIEGGRRATFILHSLQLILPKLEIAIEEDLPEGLELARLAETLVSRLESPKPGSGIPRRSGDVLDEKLHQLFQVCVRGVTLANGNVSIRETFYNTCAHYVAGIISTEPVHQSMRLQSQQVIKAAGHALIEAVCDDAYAGQETCRVSALLLLNLLAALDRQADGLLADSISQSNYLSLFLDSIRLLPIELRNAQASDTPLLLSYYQSLLSLLQELCQTKNGATYVLKTGLFQAVRDSQLFAADPDLGIDIDNPDALRKYYDLLDSVLRVVVAAVFSRGLHNEQMLEQTRIFLAENRQSMVGIFKRFAKLGGAGAADHHDALRKLTKSYLALITATDFLENSRGTTEQRSGKRKSIGKRKLSDQEEALQQPQQQQANISEFLSRNHTTPARGHHQQTSPTSKRLRLSPPLSNSVPSAYSRDRSASDRMYNFANAESRPGAPMGQSASGADLPNTTTKPRTFNATSRQNNFTPHTGAKRLVVKNLRTGSRLNQESYFEKIWGQLDAALSAIFGGGKPEISLEELYKGAENVCRQGRAAVLAKRLQDRCREHVSGKLRDKLVAKAADGSNVDTLRAVVEAWSQWQSKLVTVRWIFYYLDQSFLLHSKEFPMIREMGLIQFRQHIFSDAVLQPKILQGACDLVEADRGEEQSVVADSLLLRNTIELFHGLDIYTTGFEPLLISESKKYFSSWAQREATGYLATFAENSHRLIEREVTRCELFSLNRSTKQMLSELLDRALVTEQEDVLLNQPDILGLLRAGNKVALERLYSLLQRKDLGAKLKTAFSGYIIEEGSGIVFDEDKEADMVAHLLEFKQQLDDIWVHSFHRNEELGHTLREAFETFINKGRKSEATGGTDNPKTGEMIAKYVDRLLKGGWKLAPARKAEDMPLADEDAEIDRQLDQVLDLFRFVHGKAVFEAFYKNDLARRLLMGRSASDDAEKSMLARLKTECGSSFTHNLESMFKDMDVARDEMSAYSSIQRERRDRLPVDLNVSVLSASAWPTYPDVQVRIPPEIATAVDDFEKFYNTKYNGRKLNWKHQLAHCQLRARFPKGDKELVVSSFQAIVLLLFNDIPEGGSLGYSQIQEATMLSDQELKRTLQSLACAKYRVLSKKPKGRDVNTTDEFSYNAAFTDPKMRIKINQIQLKETKEENKTTHERVAADRHYETQAAIVRIMKSRKTITHAELVAEVIKATRSRGVLEPADIKKNIEKLIEKDYMEREEGNRYQYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN72</accession>
    <name>A0A8G1VN72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_497174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514345.1">
        <property type="nucleotide sequence ID" value="XM_025663987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN72"/>
    <dbReference type="GeneID" id="37167389"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057571">
        <property type="entry name" value="SDR_PhqE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF1">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23441">
        <property type="entry name" value="SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH56423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="303" mass="32552" checksum="1D5F0963F2E260DE" modified="2022-01-19" version="1">MTTPTPTTMNFISINKLTNTRVLLIGGTSGIGFAVARAALEHGASIILSSSKLEKVQSAISRLQQLYPDPSFTSRITGRAYDLSDQSTLETTIISLLDYATSPSIFPTTTTTTTHGNNEKVLLNHIIYTSGTRPSRIPISPTTTNLTPQLYTQSETLRVLAPLMLGKHAKSYMVDEHTSSMTFTSGVLASKPVPGTTLGAMAGSALGGLVRGLAVELEPIRANVVAPGAVETEIFDELGVQEKEAVKEMFRRGTVLGRVAEAGDVAEAYVWCMKDGFGWDVTESVYCKSSLNYSIRYMNSADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNX9</accession>
    <name>A0A8G1VNX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">6-hydroxy-D-nicotine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_415336</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518138.1">
        <property type="nucleotide sequence ID" value="XM_025657682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNX9"/>
    <dbReference type="GeneID" id="37161084"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="79"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH60216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="517" mass="56388" checksum="2D70402076FFDFD4" modified="2022-01-19" version="1">MSCEAIIATIVQGASVDASTTPTIKDLLSKYAALSDDEKNSVRASYLAQVFPLLFGENAIFRESDGYDAQRQVPWSINCWLQPLFVVTATSAQEVASALSLCRFFNINFSVRGGGHLQNPGFTSNDGGVVISFSKFNHVKLSEDKSTADVGLGLRWLDVYKALDPYGLAVAGGRIPTVGVPGLLLGGGISFQNSQYGVGAMGVTNYEVVLADSRIVNANAQENADLFWALKGGGPNFGIVTKMDLVTVPTESWAEARVYPPTAYPELAKGLMKYHEAIEVDNKASLVWHATSQAILLVFFYCAPVEKPAAFQSFYDIPFLMNFVPPGTRSIYELVQAVASVISPEVLHHEFRTMSSQPCLELYEATEKVRREQQEALSDVEGLVLTNVFQPMSSLAMKQSQKDGGTPLGLEAVGQQWFLSMADWKHAKDENRVREAVRKIVDVAEATAKQAGAYLPYRYSNYASRDQDPLSSYGAENVAKLKSIAAKYDPDGVFQKLQNGGWLLSKVGSQARSVKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP89</accession>
    <name>A0A8G1VP89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_416027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518453.1">
        <property type="nucleotide sequence ID" value="XM_025657716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP89"/>
    <dbReference type="GeneID" id="37161118"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26609" checksum="EDAD163A9B5EFE62" modified="2022-01-19" version="1">MRIVDPQSATLTNIEVLAYLTANPPRRPPNPPPNSRNWVPSPDLRDHNTVVKEIHNYVTRLSPHLLNYPKYTHLTPAQIQAQAQSTTTTAIPPSQINAPTPLDHALRELVTRLQPYGLTKGEVLMIVNLGVGLHAPATEGEDGEEAGEGGEEEQEEYDENAEQQVNGGEDTNGMMEVDGAEEAQGGGEGEIPEEDYGALALLDTVIEEREERLSNEDVNNVLAIIRETLGSGMKGSEGEGMDEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPJ4</accession>
    <name>A0A8G1VPJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell cycle control protein Cwf18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_446002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518768.1">
        <property type="nucleotide sequence ID" value="XM_025659397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPJ4"/>
    <dbReference type="GeneID" id="37162799"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="201" mass="21927" checksum="FC6A79BC0F692446" modified="2022-01-19" version="1">MSSNHASLDAAANERKARLAKLAALKRKQPEPEPLTEAGAADEELEDAAPDVTKQYLSGRNYDAEMRGPKLGFDTAPSDGQITVEAQAAEIARATAEKAKEDEGDQPIDLFKLQPKKPNWDLKRDLDEKMNVLNVRTQNAIAKLVRQRIEEAQRAAQAKGTGANGGEQGEEVGIEGDMLVQGIHVREREEEAGNDLEDDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPP5</accession>
    <name>A0A8G1VPP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_486482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH60050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517972.1">
        <property type="nucleotide sequence ID" value="XM_025663393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPP5"/>
    <dbReference type="GeneID" id="37166795"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="194"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH60050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="611" mass="69426" checksum="0560773A207CB2EC" modified="2022-01-19" version="1">MAYDGAETGSACLIGAQTAETPAEKELSQNLSNLKCWEARVLLCSGRPPPCKACQNTGGCIFDETLDLRRKVAARRTQGELEYYRGLLYSLLETLRSSDEEKARQMLEKIRGNAQLNDLVTVIDPPATDFSDASSEHSKSVGPAEDIPSQHERPVVDAHLRITVERLCDSPLFQVSSGPWTVVTNDDHIVSHLISLYFTWDHPLLQVVDQETFLKHMTTKETNPDCCTSLLVNSILAVASIYSDFPEVFAAPDDETSRGQHFYAEAERLWNAEEGRVSLANIQAVALMSRFLKFQGKDDLSWLMLRQAVQLAQDFGMFTSPRMGHRQWEKMSLRLQHACAITAWGLFILNAQTSLHSRKVAELKLPKYKPYPVTALDDDDVMWTPYPRFNQVGLAKHPAYLRFVMTKTIDLTEIIADIPELLFDKGLDMAIGELWIAANKKCVRLQRWLDSLPKDFEADDEKPPQILYLYIGYHHTIMVLFQYFLEHQHFGPTSHPSEFEQARSNQLRSAKQVVQCLRSYHEAYGLRQIPRQMLEPTNSSLLVFLSALNEDDSKDAFVELCRFLVAFSKRFALAKEMLRNLESIVQSSRLTLPPEAVAVLDHRGQETSQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPU2</accession>
    <name>A0A8G1VPU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_365296</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517989.1">
        <property type="nucleotide sequence ID" value="XM_025655735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPU2"/>
    <dbReference type="GeneID" id="37159137"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000397">
        <property type="entry name" value="Serine/threonine-protein kinase KIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="215"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="158"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="540"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="768"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1031"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="702"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="776"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="829"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="860"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="879"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="892"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="917"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH60067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1098" mass="119495" checksum="719E33E8968C6EF2" modified="2022-01-19" version="1">MNDSQSQSLPLTTHASPALTPAAPSEQDNNRSPVYPDLLGAPPVPPPRTSSTHRGHHGSSAKPSSSSAEKSSSSRHGKNKADDRSASHRERKGEDSQFRPVNMPEEYPQGPSSHAPGALSSEDNMEGYAGQGELQKESSAVLNQVLVSDPSVDIEREQVRQAGSSVSPSTESAPASGLGLVGSDGVDDGGRGGLRSRHDYSDHAVKRKETTFGQYILGQTLGEGEFGKVKLGWKRDGTIQVAIKLIRRESLGSNPSRLPKIYREISILRDLAHPNIVRLHEMVETDRHIGIIMEYASGGELFDHILNNRYLKDNAARRLFAQLVSGVGYLHKKGIVHRDLKLENLLLDRNRNIIITDFGFANTFDPMDELGDEIEYNLTNKEFVKRMRLDRPNAKGLRRGDLMQTSCGSPCYAAPELVVSDSLYTGRKVDVWSCGVILYAMLAGYLPFDDDPANPDGDNINLLYKYIVTTPLTFPEYVTPHARDLLRRILVPDPRKRADLFEVARHSWLSEYSHIVSHITSSTTKVADIATTTVTQGMDLARNPAGSVTNPVSRAEPHKEVPSLARSASVREPPKTYNNSPVPSVGGLIHHAGDISQEQAAERSKTPRDTKRRTVQVEYVAPQSQTARGEVPPTGVDAGIAEPAGPSEPRPTRARSNSRPIVPNMPSGTLARDMSGASNVRTGEPKAAAGPAPAPAPGHLPRSTSDTSALTGTAPTSATHATRPTTGGSMASFNAGRLPSRGSYGQPVAPTVAATNAQGRLAQPKSKQYVISAPLQQDSSSQQSIGQPSTQQLPAKFNTTPRQEPPKGHKRSNTVSSIGEKLFGRSGSIFGGRGGQGSGPRQKNGKRYPPTSMKEPYGGDDTRMSMDSRRSMQYGYNRKTSESGTEGRPRRFSFLPPSFSLKGFSSSRSQTPDEESQTDRSTENRVEPRPSTSAMQARSRAASYGTQDAIGAAPEGAPGDEILTQDEPINYQARIDQQFAVLHSNQSGIYQPTSYSATSAEQVYQNENDHYYRNQYANHSAPNHYEEYSAPYDKTPRPSMQAGRPGRGTGVLPKNHRKFADAYEYERDLAHRPGSSGAARKVMDFFRRRAKSRAGDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPV0</accession>
    <name>A0A8G1VPV0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_457097</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518137.1">
        <property type="nucleotide sequence ID" value="XM_025661489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPV0"/>
    <dbReference type="GeneID" id="37164891"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="22"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH60215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="338" mass="37624" checksum="D8989A7096142A3F" modified="2022-01-19" version="1">MTTTVRIIVLVLAIPTTLVCGLRLYLRKTVLNSWGLDDWMVMVALIMVNGFSALAYTITYYGLGKKTKDVSDADLLVWWKIYYAALCSYLLVAASVKTSLTVFIMRLFPTRSISIAGRCILGFLAAFTLAGTSALAFQCRPVRAGFDKTILDAKCYSVDTSFAILMAQGVIMFVMDLTILVLPIRRVWQLQMPLGRRVLVLGLFCLGFTACIAALVRFSTLTYARDETDYTYTAANSLIWMELEFNLGLMSGSLSSLRKLIKLRSPFGSRQTSSFTGSRPNNAELGRYKGWGRGISKKTEINRVFEIVDSSQEHIAPIYGQGELCTTTNAFSNRKLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ61</accession>
    <name>A0A8G1VQ61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative PKS-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_467046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518467.1">
        <property type="nucleotide sequence ID" value="XM_025662165.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37165567"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF18">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="8"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="8">
        <location>
            <begin position="840"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2243"/>
            <end position="2319"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="840"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="990"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="872"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH60545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2331" mass="253115" checksum="FAB82D907F1D35F9" modified="2022-01-19" version="1">MQTTQSPQQPLAVVGMACRLPGNSNSPTALWRFLEQGGIASTEPPSSRFNLHGHEDGTKRIRTMRSPGGMFLENIDPADIDAQFFGLSRAEATAMDPQQRQLLEVVYEGLENAGITLESLRNQPVGCFVGSYASDWGDMQGRDPEDRVPNATVGVGRAMLSNRLSHFLNIKGPSMTIDTACSGSLVSLDIAARYLQTGEIDTAIVAGCNLYMSPEHCIDMSNLSGAASPSGRCHTFDAKADGYIKAEAVNMVILKRLPDALRQNDPIRAIVRGTATNSDGWTAGIASPSPEAQAAATRQAYRNAGISNLNDTSYVECHGTGTRAGDPIEVNSVASVFCATRTAERPLLIGSIKSNVGHSEPAAGLSGLIKTIMSLEKGCIPGNPTFETPNPAINFEALKTRASRRTIQWPDVPFRRASVNSYGYGGSNVHVILDEAGTSVPPSEASFKSSYLTDDDDLFADQEQESSHLLVFSANDEAALKATVQRLQMHLVRPEVRVSLPDLAYTLSERRTRHFHRAYLVSNTPTVDQHALIYGKPRSNVPKVGFIFTGQGSQWPQMGKALVDTFPSSQRLLRHLDAVLQALPHPPQWSFPLLQQILQRHSGAVALACINSPQSVTLSGHVSALETVCHQLHEHGHFARLLQVDLPYHSPFMADIAAHYKSLLDARGPGSSSPVSPRRRGAKLFSSVTGCEMQGSVDNAYWEANMRLPVRFSEAVEAMLTDADPVDFLIEVGPSGALAGPVKQILKALPSNGAGIDYHAACRRNAFEPTALFDVAGRLFLADGPININQVNATARAKSARDSKPAVLVDLPNYMWNHATKYWWESQASRDWRFRRYPNHDLLGGKVLGTPWTAPVWKKLLRLPELTWLLDHRIGGQVLFPAAGYIAMAVEAAFQMGQSRGFIDQNLQVHNVAYRLRNVTFMKAMVLEEGTDQRIMLTLTPKDERADSWHHFTVLTLHEDATTTRHCSGMIMLETPNDEDAPWEAIKPLEYPMPAQAWYKALRDVGYSFGPSFQSQLEVEAVAGQRTNRGLVSFSEPPSSYPQSPYSVHPVAIDGCLQSGAASLWQGIRSAVGGALVPAVVDDLLINARDVAAVPVAVAAASAEFSGVGSPEEAHNYQSHIQVFDPASKRLLLKVTGLWYHKLDASPESPERQHTFMRLHWKPQMSTLSDGQIRGLVQAPHSLQKPMPHHDSSSPSRKQWTLMELLLHEKHSLRVVEFSTLPFEESVGRDIFDGDLSLGEGNCKYQFMPKNLASLRASQALLSEKYPQAQMNMLDVTKPDVDLSMLPEMLDLAILQLGPVSSADLANALANVRRAMTPTAYLLVLGTSLVDVTEDTGSASVISGEDSDSGSSDWSMIGSSSSQILDFLRSQGFERVVPLAQESLSEDTVFLAQLSSDKTIVSPPLATTSEVTVLHLTLEDKPLVKQLAIAGKAPSEQHLPLPAAAIAPSSVVVIVDEVYSATLSEVTPIQWQAIQHLTASGCKILWVTSGAQLDVTHPDRSLAYGMSRVIRAEDPCVNITLLDVESAVSTGSVGAICRTILSLQQGHQTQDHEFVERDGVVHVSRVYPDTQMNADAEKEDAITTAAALPPAQQTQNLHEHPSCVRLVCRQPGKLQSLCFAEVSSSPVPLPDDFIEVEMHAAGLNFKDVATCLGIVPENPYLLGLEGAGVVCRLGKGVTSFHVGQRVLVNRRGSFGNKVQCPVQGAHAIPDSMSFEEAASLPVVYLSVIRGLFDLANLQRGQSVLIHSAAGGVGQAAIQICQAMGADIYATVGNDAKRAVLTQQYNIPPERIYSSRTAAFAPRIWEATRGRGVDVILNTLTGRLLDESWRIVAAGGCLVELGKKDILGRRSLSMEPFNRNASYRALDMSHDSVTPQITEQLMTKMFELLASGSIRPIEPRTVFPYRDIAGAIRYMRGGEHIGKIIISREAPDNDPNVPIVPAPTQLRLRDDATYLIVGGLRGLCGSLAVYLACHGAKHLAVMSRSGFEDSRSRSVIRDLISLGTRVELVQGDVSCLKDVRRAFRQAVKPVKGIIQGAMVLKDKIYTSMTVDGFRDVLPCKVSGTWNLHAVAQEQGGVDLDFFTLLSSISGLVGQKGQANYAAAGAFQDAFATYRRDRGLAACAVDLGVIEDVGYISERQEIATRLDINIWTPINEALLHRILRASILDQHNVQARGNPTATAQIITGIPFPQPEGAMLLRDARFGALAAKEGSAATAAGKHGGLSQEMQTLLMLLQTSTADRSEQLAATIEVVNRHFMHSLGLAEPMEAAKPLSVYGLDSLAAVDFRNWLRQELKVVVSTLEVVGAKTLSALCERILSRLLENADATVGERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQG2</accession>
    <name>A0A8G1VQG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_392776</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518634.1">
        <property type="nucleotide sequence ID" value="XM_025656855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQG2"/>
    <dbReference type="GeneID" id="37160257"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH60712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="520" mass="59235" checksum="0CEF282E1E17DD4E" modified="2022-01-19" version="1">MEDGGSSDARKPESLASSSSPALHPTTDYDLSETEETLNSPDTFYSPPASPGRLSRNPSFSYHDDWETFPPLDQLTVFDLLDNLSLSQRLERLQRALNAQKDKVKRQREKLKHTSIHAKERVVGEWKRRVPTADEQLDKYRRRMKDGVERLGKQWNATATVTLREKISFIAGVMNILVSGYLLGGFPEYFYIWFSVQLAYFMPIRYYRYHKKGYHYFLADLCYFVNVLCMLSLWVFPGSKRLFISTFCLVFGNNAVAIAMWRNSMVFHSMDKVVSLFIHIMPPVSLHCLVHMTSAETLRDRFPAIYEIKFSEPGSPNHFNLLEMMGWATVPYFIWQLTYHCFITVRRAEKIAAGRPTSFTWLRKSYAKTWIGKVVLSLPESLQAPAFMLIQYLYAILTMIPCPLWFWSRWASGLFLTGLFILSVHNGATYYIDVFGKRFQKELEELKKDVARWQSSPEGVSSPTLLSSDNAATVGAKGLEESASGGSDKVGVDQIPLLDAQSTGVESGQAADNSGIRERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQM4</accession>
    <name>A0A8G1VQM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL2m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_413270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520131.1">
        <property type="nucleotide sequence ID" value="XM_025657602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQM4"/>
    <dbReference type="GeneID" id="37161004"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000128">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="10">
        <location>
            <begin position="107"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="9">
        <location>
            <begin position="210"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="260"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="349"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH62209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="407" mass="44989" checksum="984D55C10B40F838" modified="2022-01-19" version="1">MLQTRLALTGLRLPFRTLSTAVSSRAYSTVVREQENPSADEPASSTFDPSIAFAPPPTRDDAGILLRSYTPRTPGIRHLRRPINDHLWKGRPVQKLTFPKRGQAKGGRNNSGRVTVRHRGGGHKRRIRMVDFARDAPGPHVVERIEHDPGRSAHIALVRSQETKKLSYILAAEGMRAGDVVHSYMSGIPEELWKSMGGTVDPGVLAARTAWRGNCLPLHMMPVGTLVFNVGLRPGQGGQLCRSAGTFATVIAKGIDIKAKRDHSDGQEGEAGAVEQKPLTQRERQRKERISQHVTIRLQSGEVRLIHKDCCATVGVASNPNHQYRQLGKAGRSRWLNIRPTVRGLAMNAAEHPHGGGRGKSKGNVDPKSPWGMPAKSGYKTRPKWKINKAVVHPRERNQGKRRRGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQW1</accession>
    <name>A0A8G1VQW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_475310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519099.1">
        <property type="nucleotide sequence ID" value="XM_025662711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQW1"/>
    <dbReference type="GeneID" id="37166113"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH61177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="683" mass="75216" checksum="3BA87F652B0D8BEB" modified="2022-01-19" version="1">MAPSTRSSQDRRTSRPPAAACEVCRQLKMRCIRPDLSEPCDRCRRNNRRCNIPPPRPLGRRPGAVGRYNGFEKSYRKMQVQLKKAPVSADEVQRVLNTTGQEELLQVILAKLQHGSDGKMPVPTTDGALRSYHDGLPTPKEPVSNPLALLADASSAAQPLTPSLDSLCTTSGGRELLQRSVCASLGLQLSRHTLEEGFNAIYDSTLPIQSQSNYFRPPDADPPRDVGPDLDPIELGLLSLEDAHSLFSVYFVRLHPINGILDPILHTVDYVRSRSALLFTWILAITAQFDHQSASCAKRLRLHGETLSRHVHTSGYKSVEIVQGYYISLLSATPAPTLSEERSWLYTSYAVAVATELGLDQVNPFNTLASDSISQREARNHERTWLRILLWERATSAAYGRATAFPESPLTRNIEKWWLHPLADSTDKDTCAFILLRRHLAGLHHILHQQASFNHDNPHWVRDLVDSTLDPWRVTWLPGCTSKAVNPSPNISTAFLTYVYLHNRLWMLSFALNTSSIHSYALQEDCFTAAVQCCILAVHDLQSIGEPLYCLLSPSWAMIAYAAALALRLFSALYDAHAGDEGELLGLLGQVALQLEKAGSTPSHRIGIAAVLGRHLLSVLRAKVGIRMGIGDFADSRLHCSSGSGLVGSSCDPVLGSVAMGLDEGFADVFREVFGPGWGLGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR23</accession>
    <name>A0A8G1VR23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_409783</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520566.1">
        <property type="nucleotide sequence ID" value="XM_025657446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR23"/>
    <dbReference type="GeneID" id="37160848"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF1">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="9">
        <location>
            <begin position="412"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH62644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="699" mass="77997" checksum="6D1C4BE228589BFF" modified="2022-01-19" version="1">MEKITDKIAALPPDANYFSLEFFPPKTKMGFANLQARLERMAQALRPLFVTVTWGAGGSTAARSLELAEICQRQLQLTTCLHLTCTNMSRALVDEALEEAKVLGIRNILALRGDPPRSEEYNMHGEDDSNKDFTFAVDLVRYIRKQYGDYFCIGVAAYPEGHPADNFQDVQDPARDLPYLIEKTQAGADFIMTQLTYDLEAYTKFETMLRNHESGVFKTIPIVPGLMPIHSYKILTRVTKLSHVKIPPQVLSKLEEVKHDDDAVKRIGVDIITDLVYGIRDLVSPGLRGFHFYTLNLEKTVSFILERCELIPPYTEIDDSDALVDGGNLSAMDSSSYIAPNGAPIRTLASRRSSVSSIPHNRVIVDKVQISEPSSKDSITHEASALSAGLPAMPPDRSTTLQISEGLGALGREATWDDFPNGRWGDARSPAFGEIDGYGPSLHVSAATARRIWGYPVTREDISTLFRRHVSGELHMVPWSEGGAEEDSNGLNAETAVIQPELLTLIDKKGWWTLASQPALNGVRSDDPVFGWGPPGEGFVFQKPFVEFFCPTKDYLTVLKPLLQKHGHEKLAWFATNVKGDFESSLPGPNPDDPDPIDINPANVNAVTWGVFRGKEIVTPTIIEEVSFRAWGDEAYRIWDEWRRIYPKNSATERFLDETKNDVWLVCVVGQEFGAGTEAGSEEEEDEKKWMWRELANSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRD1</accession>
    <name>A0A8G1VRD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_454878</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520718.1">
        <property type="nucleotide sequence ID" value="XM_025661349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRD1"/>
    <dbReference type="GeneID" id="37164751"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="61"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH62796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="403" mass="45828" checksum="B14A7AC005A7CF77" modified="2022-01-19" version="1">MKSSTLGSIIAPKISQNAQKFPTSGFDIIQSDQKVEEEELPDYKAHRFYPVRLGEIFQNRYQTVAKLGFGSSSTIWLSRDLINGQYVALKVYVHTSSVHRELPFYDHAKQQLQTSSHQGRYNIRKLLDSFTVSSQDGTHIVLIFEATQMSLRDMEVVFQQGGFDENLVKAAITELLQAVDFLHTQGQVVHTDIHPGNLLLGAYDNQSLSALEHEELVSPVPRKPVSPTRTIYLSRLMRPQVGPMLLSDFGETRIGPGPHGGDIMPMEYRAPETLLYIGWSYPVDIWSVGLTAWDLLEPRNLFTARDEDGELYDAAHLAQIIAALGPPPPEFLRRNQKRRSDFWDSDGKWLGLAPIPHDRTMERLDSRLSDKSGFLRFMRKTLTWLPEERATAKELLQDPWLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSS5</accession>
    <name>A0A8G1VSS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_410982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521154.1">
        <property type="nucleotide sequence ID" value="XM_025657505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSS5"/>
    <dbReference type="GeneID" id="37160907"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF8">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="260" mass="28001" checksum="54B32ABB0234D1BC" modified="2022-01-19" version="1">MSSANLPIIVIVPGAFGTPEGFDKLLPYLTEAGYTTHPGSYPSCNPSDPTQVSSSQDIAHLRNNVLLPLLNENGKDVVIIAHSYGGVVAGGAAKELAKETRAAQGQSTGVVGLIYVVGNITLEGESLFQAVGGAYPPFIKVDKPSQGLAVIEPAMDVLYNDCDRVLEPELDTLMQPHALRAFETPPTAPAWAESAFDGRRAYVRTLDDCCNPAFLQDIWLEKSKVEWEVVDFKAGHMPFVSQPQALAEQITKFIDGFIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSU2</accession>
    <name>A0A8G1VSU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_495158</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521227.1">
        <property type="nucleotide sequence ID" value="XM_025663901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSU2"/>
    <dbReference type="GeneID" id="37167303"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF2">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034337233" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH63305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="529" mass="58122" checksum="1A6488C2C173D580" modified="2022-01-19" version="1">MGLSLALATWASLLAVASAQSKCSLPAGDICAYENATTYAAVNAPNCTTSGLQAFVNKLPGLNGTTLSVPYAFYVDSNETLDEFTDYVGASTFTTDIPSVCAFRVNGTNEQGVSWGLGALLPTHFNGSIMMAAPDSGISWGVASAGLRYAFATFASNSGHDEPDHVSGWETPNGNYKAWYDVEPKYSYITGCSDGGRHVMKSIQTYPEDYDGAMAGAPTWWMTHQAFYNYKQTTIGGLAHSNSSIPPKLYPTRLTDSIISNPQGCFFHPEALACSSNKTSNCLTAPQLDTLHKIYNDWTTFDQDLIYPGAWFGSEPTWNTTFGNQHSKSWYIENVLGFKNLTAQDLAYELISEADARNPAHANADDFDLSPFFNRGGKFFHWHGMSDSVVSPGSSVYYHHKATYAALEKGIDIDQHYQLYLIPGLKHCTGTPTCMSALWYLAGPYQAGNFFNFTPANVVDNYVHDSLLTLISWVEDGHGPSYMVTTNFEDNADPTTLLHNRKICPYPRQANWTQTGVSTHEDYWDCVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VTI2</accession>
    <name>A0A8G1VTI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_474411</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519760.1">
        <property type="nucleotide sequence ID" value="XM_025662659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VTI2"/>
    <dbReference type="GeneID" id="37166061"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="218"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="378"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="466" mass="51547" checksum="6EEDA4A5A425120C" modified="2022-01-19" version="1">MAPDKKDKKRKAAAATAADSPAKKTKKVEAKPAESPKDAPKPILKKANQKEAATKTDGASKTKANGQPARQIKPRKRAADFLSDNENSESEAEVAEPKVAKEEKPTAKKSKKEDGSAAPATKSKPAKANTKAKKAEPVVEESEEDESAASEASQSEDEEDDRTAALIRGFESSGDEDESGDEGFNPDQPVPQIPDSKKAKRKILKKQKENAGHVEEPGTVYVGRIPHGFYEHQMRAYFSQFGKITRLRLSRNRITGRSKHYAFIEFAHTSVAKIVAATMDNYLMYGHILKCKYVSPEQLHPEVWKGANRRFKRTPWNRIEKKRLDKGKTREQWTERIEREQKRRLAKAEKLKAIMGYDLDIPQLKSVDEVPVQEAKAIEASEPAAEEPAKAIEAAPVEEPKAEKPAEDTPKKTNKKTKKAAQSPAAQETPKSAEKSTPKKTTEETASPAAQKAKKVQKKTKAKSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VUJ6</accession>
    <name>A0A8G1VUJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_410277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520825.1">
        <property type="nucleotide sequence ID" value="XM_025657471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VUJ6"/>
    <dbReference type="GeneID" id="37160873"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034883235" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="695"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="791" mass="88981" checksum="7921E5B389B7D655" modified="2022-01-19" version="1">MRLSCALLMLLTVGVYSAELGGRTAKALSTAAPDRDGQDLFLTPQNNYNGWVNPEDLRPMPQCIAQQDQSTWLEIMTKCTAKRCTSHFGFICTHLQWLTHLGCLSVAFSSDVIARYLPYCGRSILAKAQLYSWIRDITGREWLVEVGDTNELQSLSPASLAEGYSTVDVLKTAPGCLTGSVCSFSREPFQRVMASCGFTSASHHTGNAARPWEYDEPVRSIIALDSETVGYDLVQQHIKDGYYFDKGCFCSSFAVDFEEEPCSDSERLDWTKQRLWLNATCGSKSLPDNWTDALLTTQFAFIALDGWSWPKCVMDMPKKVTGLTDQCAADACKLDSSGYCQVTRAVDRKCFCQHISYDSCEGSCQIFETRIDYIRWLHDLCGGIQDWQGLPNNWRQLSAPTLTEMIPWQWALKPSMAPDSTPITQPGDNKATEACPSTQWKLGSFAIINIATFIALLLCQRKHMLQSKNVNSEHSQPIYWAFKGILLATIQVFANLFSSVLVQKIPGYEEVPIFQLMLLWCSMPRLSWLMMFLLGLQQFGPKSLSAAASLLFAEILLQLLSAYYILITVYYGYEHNFYLGTVEIWVPAKIMYAGALMWLLTVIMAFAVSIRAMRKVEKSRVSVFTSLNISEEGMPPIKEYNNIRTGRMFHRATGRPRAPEEAPLIRDQSNRTSYDPILVQPRLISLPHRPRLAEVYAATTSFLLFLWIAQLLFWGGFIGLSSEEYVFPACAMQIAVHIDSQAVLRFCPPILGTIWKLTQHTYVEVQGDLPAALRKHHGTPRPVVGIWTCNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QR10</accession>
    <name>A0A8G1QR10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-phytase B</fullName>
            <ecNumber evidence="3">3.1.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Myo-inositol-hexaphosphate 3-phosphohydrolase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_408778</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolysis of inorganic orthophosphate from phytate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16989"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="EC" id="3.1.3.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="3"/>
    <dbReference type="EMBL" id="KZ825089">
        <property type="protein sequence ID" value="RAH52007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509929.1">
        <property type="nucleotide sequence ID" value="XM_025657413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QR10"/>
    <dbReference type="GeneID" id="37160815"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000042">
        <property type="entry name" value="Acid phosphatase aph, 3-phytase phyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF18">
        <property type="entry name" value="ACID PHOSPHATASE PHO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034067127" description="3-phytase B" evidence="12">
        <location>
            <begin position="20"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="71"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="413"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH52007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="479" mass="52706" checksum="4F8E0F2BA9013B08" modified="2022-01-19" version="1">MPRTSLLTLACALATGASAFSYGAAIPQSTQEKQFSQEFRDGYSILKHYGGNGPYSERVSYGIARDPPTSCEVDQVIMVKRHGERYPSPSAGKDIEEALAKVYSINTTEYKGDLAFLNDWTYYVPNECYYNAETTSGPYAGLLDAYNHGNDYKARYGHLWNGETVVPFFSSGYGRVIETARKFGEGFFGYNYSTNAALNIISESEVMGADSLTPTCDTDNDQTTCDNLTYQLPQFKVAAARLNSQNPGMNLTASDVYNLMVMASFELNARPFSNWINAFTQDEWVSFGYVEDLNYYYCAGPGDKNMAAVGAVYANASLTLLNQGPKEAGSLFFNFAHDTNITPILAALGVLIPNEDLPLDRVAFGNPYSIGNIVPMGGHLTIERLSCQATALSDEGTYVRLVLNEAVLPFNDCTSGPGYSCPLANYTSILNKNLPDYTTTCNVSASYPQYLNFWWNYNTTTELNYRSSPIACQEGDAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QR11</accession>
    <name>A0A8G1QR11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MIP transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_492846</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510643.1">
        <property type="nucleotide sequence ID" value="XM_025663798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QR11"/>
    <dbReference type="GeneID" id="37167200"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47002:SF2">
        <property type="entry name" value="AQUAPORIN AQPAE.A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47002">
        <property type="entry name" value="AQUAPORIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH52721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="320" mass="34127" checksum="19A3FBA6A9C24290" modified="2022-01-19" version="1">MAGLLFRPQNDIDPSVNVQQLSCKPHVPPFVGRIGGNQGIVLDRADPDNAEFLRKVPDAAPLMSARDSFNVRGFTDLNLWRFAVVECVGTMMLAFITAWSAATPANVAPPTPTTPAGIFATTAFLGPLVGAFTNWALLTLFIFSFLAVSGSHLNPTITLATFFARLISLPRMVLYLAGQILGGALAGWILQSAFGSGQYSVGGCVVDTALVPVREAFVLEFICCLILIFLSFGVGLDPRQVRVYGAALSPWLVGMVLGVVSLGSSYTREGYGGASLNPARCFGVYVGSSFPGYHWIHWVGPLAAAIGHGLVYYLVPPWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRF4</accession>
    <name>A0A8G1QRF4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_408300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510200.1">
        <property type="nucleotide sequence ID" value="XM_025657393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRF4"/>
    <dbReference type="GeneID" id="37160795"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH52278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="319" mass="34852" checksum="5B19679CB78DCD26" modified="2022-01-19" version="1" fragment="single">MSSFSAQSTSEEVCQVLADHIKGSKVLITGVTLGSVGGEAALQLSRHQPALLVLAGRNLRTLQATENAIKAETPDANTRLLILDLSSQKSVRMAAAEVNNYPERIDHLINNAGIMAAPYTTTPEGVELQFGTNHIGHFLFTNLLLGRMTSGESKVRVVNVSSAGHKRGPVRFDDVNFENGKCYDKWQAYGQSKTANMLFSVSLAEKAGEKGVESFSLYPGRRETGIGRHLKPEEWVKAGWKHQDGSINDDPKLNWRTASQGAATLIVAAYDPSISDKNGSYMVNNQVNNGEAVDYALDPKIAEKLWKLSEEIVGQKFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSB0</accession>
    <name>A0A8G1QSB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-ornithine N(5)-monooxygenase</fullName>
            <ecNumber evidence="4">1.14.13.196</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-ornithine N(5)-oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_454643</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="KZ825097">
        <property type="protein sequence ID" value="RAH51674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509596.1">
        <property type="nucleotide sequence ID" value="XM_025661334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSB0"/>
    <dbReference type="GeneID" id="37164736"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38663">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38663:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH51674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="381" mass="42869" checksum="4ECFB4AEFAED6EAA" modified="2022-01-19" version="1">MRSRAQAVGEVEIDERDRKDYFSPSTDLFEDYCGSIVSRYGLDAPGMIRQCEVNDISYDYRSELSPSDKIFTVTTAEGSRFYSRVVVLAIGPGRTKILPFKLTGEEEKGACHSTEIRMFPSINVKAKIKQRQETNVVVVGGGLSSAQVVDMAIRRGVTKVWFLLRSDFKVKHFDLALNWMGKFKNFEKAAFWSADTDEERLEMIKAARNGGSITPRYQKILKQHVAAHRLSIHPRTVICGKEYCASSRTWRLTTDPPIPDLPRIDYIYFATGMQADVNELPLLQRMNREYPIETKQGLPCITDDLMWQSNVPLFLTGRLGSLRLGPGAANLEGARLGAERIAWAMEDVLGRKGSEDTGSERSKQCFCGLGNRYAELANVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QST1</accession>
    <name>A0A8G1QST1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_430687</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510905.1">
        <property type="nucleotide sequence ID" value="XM_025658298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QST1"/>
    <dbReference type="GeneID" id="37161700"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003346">
        <property type="entry name" value="PRK04366.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="9">
        <location>
            <begin position="78"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="9">
        <location>
            <begin position="552"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="881"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="835"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH52983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1060" mass="115014" checksum="55CE6829C4A74632" modified="2022-01-19" version="1">MAASLCALRGTRQLALRSRLRAAPSPIAVRRASPLVRSLHTTTQQSPSARRPVYTSSVADHGVPHPPDLFQPLDTFPRRHIGPNPDAAKEMLATLDPPVASLDEFVKQVLPADILSKKDLKVSAPHSTANLPRSSVHGGLGETDMLKLLDTYRKQIDVSGKTYLGTGYYPTIVPPVVLRNVLENPAWYTSYTPYQPEISQGRLESLLNFQTLTADLTGLPFANASVLDEGTAAAEAMTMSLATLPMSKQKKAGKAYVVSHLCHPQTIAVMRSRAEGFGINLVVGDILADDFKLVKEQGDKLIGVLAQYPDTEGGIYDFQSLSDTIHGNGGTFSVATDLLALTLLKAPGEFGADIAFGSAQRLGVPMGYGGPHAAFFACADKYKRKVPGRVVGVSKDRLGNRALRLALQTREQHIRREKATSNICTAQALLANMTAMYAVYHGPAGLKAIAQRIMSMTTTLQAKLAGLGYNVPIKSNSADGGALFDTVVVELSGAQETDAIIAAAREQSMFLRRLSDTKVGISLDETVGREEVKSILKVFAAHASKAEVGLEEDLAVAPVPASLERTSAYLTHPVFNTHHSETEMLRYIRHLESKDLSLAHSMIPLGSCTMKLNATTEMIPVSWPEFSQMHPFLPADVAKGYTQMIDDLEQQLADITGMAEVTVQPNSGAQGEFAGLRVIKKYQEAHEGDKRNICLIPVSAHGTNPASAAMAGMRVVTIKCDTKTGNLDLEDLKAKCEKHKDELAAVMITYPSTFGVYEPGIKQACEIVHQHGGQVYMDGANMNAQIGLCSPGEIGADVCHLNLHKTFCIPHGGGGPGVGPIGVAEHLRPYLPSHPGSEYLQSKRSESSSPPISAAPWGSASILPITFNYINMMGSKGLTHATKITLLNANYILARLKDHYPILYTNENGRCAHEFILDVRKFKDTCGVEAIDIAKRLQDYGFHAPTMSWPVANTLMIEPTESENKAELDRFCDALISIREEIAAVESGAQPQEGNVLKMAPHTQRDLLSSEWNRPYTRETAAYPLPYLVEKKFWPSVTRVDDAYGDQNLFCTCGPVEDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSW4</accession>
    <name>A0A8G1QSW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_492447</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510971.1">
        <property type="nucleotide sequence ID" value="XM_025663776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSW4"/>
    <dbReference type="GeneID" id="37167178"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH53049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="472" mass="52345" checksum="26366A8C9A884F2B" modified="2022-01-19" version="1">MSKPNSQRPFHVIIVGASIAGLTLAHCLSNTGIDFTILEARSDTYPDGAGLAILPNGARILDQLGLYQDVLDQGQCMVSHSTWLETGHLLRRVDAGRIRSFGRFDYPVLVIARRALLGILYTRLQSSRLFFNRRVVRIVSSSDNVTVHSADGMRVSGDLVVGADGVHSTVREQMWHHIRDIYEAVASSRWFSEIPLTDSFAGVFGIAQSISGLKKGDVHRTYGHGWLTVIMVGADSRVCWFMSIARTMMPVLIPRHTADRAYVSRIVEPFLKKHVTSDVTFGEVFNRSDSCVVASLEEGFQNRWSWGRFVGIGDAVHKMAPNIAEGANCAIESAASLANHLVFFARGSTPLYTEDRLTPMLKAWEDSRKRRTRGLFLISQCAVRIEAATSWVLKLNQVFLSHFHGTGIGLLTSITSRTARVDYLPLPLPQQSSRSQVLGKKEHESGWNWKVIVLPLAAATSLMFHVLHALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT21</accession>
    <name>A0A8G1QT21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nonribosomal siderophore peptide synthase Sid2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_408578</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509986.1">
        <property type="nucleotide sequence ID" value="XM_025657405.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37160807"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904091">
        <property type="term" value="F:non-ribosomal peptide synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000034">
        <property type="entry name" value="Nonribosomal peptide synthase sidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056896">
        <property type="entry name" value="SIDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24895">
        <property type="entry name" value="SIDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="733"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1525"/>
            <end position="1598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2042" mass="223283" checksum="3FA0B966C1C35F1C" modified="2022-01-19" version="1">MAGVHTLEAAGLGADTTPSGMKEELLLVSWLIVLLRTREDGQASFEWAYKGDEASPVNRCLSTEVMADLRSSVGQTAAAIARKRTTTPETVPSTSLAVLLSTSALSQTTEEPNEGIIHLEACYNANNLEIKPVWHSEVILPYTLTRHINSLIDTVQLVLSNPDATIEECLRPTASDISDIWSWNHKLPPAYDFGMHEVISEQARKTPDKVAIDSWDGSLTYGVIERYSTYVAMKIQEMGAQPEDFIPVCFEKSRWTIVAVLAVMKAGCTFAMMDPTLPLARLQNMAKQVNARTMICSSMQQDLSREIIQDGGLFVVEEGAFPNVPPLEDTPVLPKVPSTTIMYLIFTSGSTGTPKGVKVSHGSYTSSAFPRAKAVGYDENSRVLDFASYAFDVSIDSMLLTLGNNGCLCIPSDEDRLNDINGVIRNMRVNYAGITPSVARILEPDVIASLSGLGLGGEAASARDVTVWGQETRIIIGYGPCECTIGCTVNSSAATGRDYISIGTGNGAAIWIVNPNDHDELMPVGAVGELLVEGPIVGQGYLNDPEKTAAAFIEDPKWLVAGHQGYAGRHGRMYKTGDLGMYDPDGSGGIVFAGRKDTQVKLRGQRVELGEIESQLKARLPSEATVIAEVIVPQGSGGQATLVAFVASQASKGIDNTEVTSVELPEELSKTLSQADAEVKKVLPRYMVPTAYIPVSHVPVLISGKTDRRRLRQFGATVDLRELDQGAASTAHRELTELEQRLRQAWSQTLKVDAETIRPDDNFFALGGDSLAAMRLASVCRAQGLDLSVANTFGHPTLSAMASKVLICDVETQTEIPPFSLISQPAESACEEAAQVYGFDKAAIEDIYPCTPTQESLFTFSLKSVKAYVAQRLACIPADVDLDAWKHAWEEVVSAIPILRTRLAQLQEPGLQQVVLKDGITWKHSTDLARYLEEDRDEKMNLGENLARYAIIDHPADGKRYMVWTVHHVLYDGWSEPIVLKKVSEVLQRQQPKVEAQMRDFVKYVRDTDEAAMEEFWRRELKGAVGPQFPRLPSRDYLPIPDGMIERHINLETNSGSPFTMATLIRAAWALVASQYTGNDDVVFGETLTGRDIPLAGVESIVGPLIATVPVRIHINRAGTVESYLQAVQQGILSRTPYQHMGMQNIRKVSHDAQHACEAPTGLVVQPEPEYAGSELGFEVGDVVREALHFNPYPLMLGCGIKKGGFRICASFDSSLVEISQMERILAQIEVACSQLSQGLTRRIDEISCLPEAELNQIWHWNQTPPLSLNESSKRLRAEEGIKEGSKYPPAVVPWVCDARNPSLLSPIGCVGELWLEGAILAGETVDSPAWLVSGSSGYSGRTGRVQATGDLVQWREDSSLVFVGRKENVVSVKGHAVNVAEVEAQFTKNLPSTVRAAAAVSQPSSELEPELVVFIEQPTSIQDGLELLPTQQEIRCDADSQSFEATVCASISVSLAVALKKLDKFIHDSLPSYMAPFAYIVVDRVPNHNVLNQLASSIPRDMLVQLRDAFKQALAKAAAQTNLTPSEAILRSAWAATLKLSPEQIDVDDNFFRLGGDSVLAMKLVSSLRAQGHGLTVADIFQRMRLGDAAKALRVNVVSKEEKVQPYHPFSTIGQKDNLESFLSEVIRPQLTNPEWSIRDVLPVTDIQALDVRGTVQAPRTSIQYTMLYFDQDINREQLHRACHEIVKAHDILRTVFVEHGSSFLQVVLDDITAPMAIHQTTSTLEDEVNSLCKTHSETAFQLGSSFTQFLHIEHTPTQQSCLILGLSHAQYDGVSLPLLLRDLETLYTSGQIPTPTPFSSYISHTLSPTPQTKALTYWKNLLQGSTPSVLPTQQQQGSKSIFHTAPIPLPFPFNLEGITTATLLTSSWALLLARRLQTQDITFATVTSGRTLSSLPSPDSIVGSCYQLTPTRVQIQPSWQAMDFLRTVQSQAAESAEYDFLGLDKIGNALNWDKSVGSVVHHQDWDDFDEMPFAGGKCKVDILNPDGDAADPMKVVSFVKEGVMHVGVVGWEGEETVVDEVLNELVGVVGELVGGGEVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT39</accession>
    <name>A0A8G1QT39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_473156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825093">
        <property type="protein sequence ID" value="RAH51780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509702.1">
        <property type="nucleotide sequence ID" value="XM_025662605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT39"/>
    <dbReference type="GeneID" id="37166007"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH51780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="249" mass="26526" checksum="63DE7643603E6C0C" modified="2022-01-19" version="1">MAQQGQTALKLHLLNQVGENRSSDQPGSGAQNGWGVDPSAGGRISIGAAGMANASSTPAKCPANPRGGRAAIMPGILTQYQGSLRSNDLQLGHYITNQSLCIIAIQRLSSSSVAWPCKTAVTPNPWSKLDLAAGPSSVGNDLDANCLHVAALDDRPQGSHDRRTAAPSTHGIIPFAPEQLALSLFACIVLPCRHWSQLEIRVRAANATDFMLASSTIYLQTPFQQSPAACYSYYVVHKPKWLQLLVGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTV2</accession>
    <name>A0A8G1QTV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_524558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510077.1">
        <property type="nucleotide sequence ID" value="XM_025665422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTV2"/>
    <dbReference type="GeneID" id="37168824"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH52155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="293" mass="33112" checksum="5A0CBD79A9AD0BAA" modified="2022-01-19" version="1">MRPSTRLLILTTPPIILTYTTHRYLCTLEAKYPPIDPTTTTSLALRTPSNPTTQHCPEVDVYEARHIPVKSLLKRYSTLLQSHPKTHDSTTTNKATLTNAWILTFLNTKPLIVEGSLVGLIKNKSYSPGDTGLTNPEFIPTSTPTTTSSLTYKLSSLFITPKPQNPAYPIEQEKRSDRSLLNSVFTIQQTSSPTTGLLLSWHMPDEPRLFFEKIARWGYPWRLMSGGRHELSISEVYVYEGEEVVDVRFASAHDYEVISDEEPTQKIVPAWVGRLHRGYARALVDWAVRDLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QU59</accession>
    <name>A0A8G1QU59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="5">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_405271</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="5"/>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511640.1">
        <property type="nucleotide sequence ID" value="XM_025657294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QU59"/>
    <dbReference type="GeneID" id="37160696"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000076">
        <property type="entry name" value="Mannan endo-1,4-beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034151338" description="mannan endo-1,4-beta-mannosidase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="12">
        <location>
            <begin position="42"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH53718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="386" mass="41662" checksum="C6C42329F13B0F0F" modified="2022-01-19" version="1">MKFSSSLLTLASLALANLSTALPKASPAPSSSSSSSSSASTSFASTSGLQFTIDGETGYFAGTNSYWIGFLTDDSDVDLVMSHLKSSGLKILRVWGFNDVTTQPSSGTVWYQLHQDGKSTINTGADGLQRLDYVVSSAEQHGIKLIINFVNYWTDYGGMSAYVSAYGGSDETDFYTSDTMQSAYQTYIKTVVERYSNSSAVFAWELANEPRCPSCDTSVLYDWIEKTSKFIKGLDADHMVCIGDEGFGLNTDSDGSYPYQFAEGLNFTMNLGIDTIDFATLHLYPDSWGTSDDWGNGWISAHGAACKAAGKPCLLEEYGVTSNHCSVESPWQKTALNTTGVSADLFWQYGDDLSTGESPDDGNTIYYGTSDYECLVTDHVAAIGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUE7</accession>
    <name>A0A8G1QUE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_491579</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511775.1">
        <property type="nucleotide sequence ID" value="XM_025663724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUE7"/>
    <dbReference type="GeneID" id="37167126"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000272">
        <property type="entry name" value="Condensin complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000920">
        <property type="entry name" value="Condensin complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="13">
        <location>
            <begin position="87"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="1003"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="824"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="891"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH53853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1188" mass="132792" checksum="2A26E31A912272EB" modified="2022-01-19" version="1">MEDRIQFDINESLKHYLSDPASVPTPDADPELLDCETDPDQLSGALIDNVLNPIVDAVAENPEGLARSSSFDSLQFLLKYCSFSPTRSLSKLLDLIVSGLSVEADIIHGELESDEQDGIQHHKQLLEMYGFLLQWALSAVEVKAAEKPTEPVPARRGAGKSARSKTNAKDGNWDWTTQIQISMETMCKVMKLKLSRIFLTTSDRDTFINLFTRSIYLILESEQRVKSMSIRMHAFKVLCIAVKHHGHAFGAQTSIVQSLTYFEHLSEPMAEFLHILAEQYDYPQLSDEILKELGNKEFNSNDTRGPKSVSAFIVKLSELAPRLIIKQMTLLAKQLDSESYTLRCAVIEVCGNLIADLSRQEERSDNYKTQINAFFDVLEERFLDINPYCRCRAIQVYMRICDLEQKFPKRRQAVAELAARSLEDKSSNVRRNAIRLLAKLVSTHPFSVMHGGQLSHKEWSARLDTVDAELNALRPPETPGFDGADASHVDSALLDDATQLPEDSPSKASGLTDEEKATAIKKAAEQAATSELLARLQLTRKYYNEAIRFIEVLHSSSGLVAQLLSSRNKSEAIEAMDFFVVLDAYKVETSRSGIRRMLRLIWTKGNSDEGKGVQTHLIDCYKGLFFEAPDSFSPNDAANYIARNMISLTFGSTPAELTCLEQLLSTMMRAGHISDAVIAKLWQVYGVQKKEISKTQRRGAIIVLGMLALADPEVVIKEIETMLRIGLGSLGRSDLVLAKYTCIALRRMVPGRQAKSKDVGIPKLGNDHAVLTKLGAIVESISDSKEWYGVAEQAIGAIYALSKHPDVLCSDILKRKTRFVFQPQLQRSPSKVSDDGEEQRPETASTEGHGAKQETSSTSLSQLLFVVGHIAIKQIVHLELCELDFKRRKAEQEKNKTANTSNQKNDNAEDDELDLIGGTTEDDFQDAMAHIRERELLYGENSLLSNFGPLVTEICANSNIYADRNLQAAATLCMAKLMCVSADYCEKNLPLLITIMERSEDPTVRSNAVIALGDMAVCFNHLIDENTDFLYRRLNDDEASVKRTCLMTLTFLILAGQVKVKGQLGEMAKCLEDEDKRIADLARMFFTELAGKDNAVYNHFVDMFSLLSAERNLEEASLRRIVKFLIGFVEKEKHARQLAEKLAARLPRCETERQWNDVAYALSLLPHKNEEITKTVTAGFNKVVTANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUQ2</accession>
    <name>A0A8G1QUQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">feruloyl esterase</fullName>
            <ecNumber evidence="1">3.1.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ferulic acid esterase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_491448</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AB hydrolase superfamily. FaeA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="1"/>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512115.1">
        <property type="nucleotide sequence ID" value="XM_025663717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUQ2"/>
    <dbReference type="GeneID" id="37167119"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005592">
        <property type="entry name" value="Mono/diacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03893">
        <property type="entry name" value="Lipase3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033993682" description="feruloyl esterase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Mono-/di-acylglycerol lipase N-terminal" evidence="12">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="11">
        <location>
            <begin position="104"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="311"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH54193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="352" mass="37395" checksum="18AD2E9F2C2A4A03" modified="2022-01-19" version="1">MFSGRFGVLLTALAALGAAAPAPLAVRSVSTSTLDELQLFAQWSAAAYCSNNIDSKDSNLTCTANACPSVEEASTTMLLEFDLTNDFGGTAGFLAADNTNKRLVVAFRGSSTIENWIANLDFILEDNDDLCTGCKVHTGFWKAWESAADELTSKIKSAMSTYSGYTLYFTGHSLGGALATLGATVLRNDGYSVELYTYGCPRIGNYALAEHITSQGSGANFRVTHLNDIVPRVPPMDFGFSQPSPEYWITSGNGASVTASDIEVIEGINSTAGNAGEATLSHPRVATTIASGASVVLLYYFIRRPTFHPHPAPPQNLPESVNSLEPPPASTSPTPDRLRSSNRAAMFPAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUS1</accession>
    <name>A0A8G1QUS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_428754</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH54018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511940.1">
        <property type="nucleotide sequence ID" value="XM_025658216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUS1"/>
    <dbReference type="GeneID" id="37161618"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF210">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="93"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="533"/>
            <end position="534"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH54018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="600" mass="64682" checksum="5E1606548536461D" modified="2022-01-19" version="1">MATTAYDFVVIGGGTAGLVTASRLSEDPNTSVLVLEAGADLTADPRVNIPIFYAALLGSDADWKFQSAPQPGLNGRVIGLNQGKTLGGSSSLNAHVFVPPFKGAVDSWEELGNPGWNWAILKDYLTKAYSSPTVAQDDKESLAIEDWPELNAAKGPIQTSFGNVTHPIRKAWAELFRSCGEYNGGDPFIHSSVGSFSCLASIDAEGKRSNSALAYYKPVELRQNLHVLTNALVERVLFDEGKPPRAIGVQYSIDGASKIVQAKSEVVLAAGVFQSPKILQLSGVGGAELLNQHGIDVVMDLPGVGQNLQDHMISYTAFQAKPELETKDSLMRQEPEAIGQAMQEYAATQSGPLASLGVHTYAYLPLPEQDRSDLQALFTSDSAKKSQHKATQSYYDIAKTTILDPKQPSAAYLSALGQTNYAKDLRDGSIPDASPGKFVTLGVMLSQPLSRGSVQITSNNPETPPIIDPGYMSNPLDMEVMAHHLLRIKKLAESPQLGELLEQPLKFRDPDADFQGDLDAAKKYARDNLVSMWHFAGTCSMLPREKDGVVDTNLKVHGIEGLRVVDASAIPLISTANLQATVYAFAERAADLIKQNQKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV16</accession>
    <name>A0A8G1QV16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_492006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511413.1">
        <property type="nucleotide sequence ID" value="XM_025663752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV16"/>
    <dbReference type="GeneID" id="37167154"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="83" mass="9155" checksum="25E9E79DA5DE26CD" modified="2022-01-19" version="1">MESSQAFSLSRRAVAIAMPLWARDDSDSSSGEKPVSNFLKSGVPGIIVGIFFLIAVSVCCYFLWRNKKRDAKEAAAVRDWNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVA1</accession>
    <name>A0A8G1QVA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_452871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511548.1">
        <property type="nucleotide sequence ID" value="XM_025660923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVA1"/>
    <dbReference type="GeneID" id="37164325"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="253" mass="28995" checksum="7A1E99C6C269C10F" modified="2022-01-19" version="1">MIIPSNIIWFDDDDWLGSELSFPAGSTWRLTKKIKESEDIYSQRDHEDDVAISEARAVFVASRGPGAAPTTAVLKVHMQIPWWGSATKKPLIRAQQAVSETPTRGTREVEALTLLTKAGCSSTPHLIDWMKRQQTQDEWVPGGFIHFIMMEMVPGVDVSLNFDILDRKERDELRAAFKASFLECTACGIVNRDSGSQNLRWDAERQKCYIIDWEMHHPSRKRDEIWSDKKYISWNLARVGEDGDYDDMSTWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWK2</accession>
    <name>A0A8G1QWK2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-antigen, N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_521606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513658.1">
        <property type="nucleotide sequence ID" value="XM_025665208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWK2"/>
    <dbReference type="GeneID" id="37168610"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="39"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="511" mass="55896" checksum="C0B4457517FA0522" modified="2022-01-19" version="1">MATSSIITRGSSSLANFTVRSRPKVDIILANQTDGLVPSFTTGDTIKGTVTITVDHDTRFDDLEITFEGTSRTSVERQSMPGRTGAYHTFLRLRQPIDESAYPTPRVLEPGRNYEFPFTFVVPERLLPHICNHAKTNLHVEQSHTLLPPTFGDPMIASNRKSVIDDMAPEMCRISYLVRVTLQRKPMAQNASPVTLVSVGKKVRVIPAVDEEPPLNVEDNDDLYSVRKEKDVKRGLMRGKLGRLVLAAAQPKPVQLSPSDTGNCDSVSTVATMQLRFDPVGNEQPPRLGTVWSKLRVSTFYSSDPWGDYPSAECIKSWAQMGRAMYTETVPLSTMCVASAQWTKHTDTDLERRDSMHSTSSTDSLPGPSASFAGNTYYTASVVVPVTLPKSKSFVPTFYSCLIARAYALELSISYHAANSRILTPTASLKVPLQLTCEAQPGTGAKGTVVDISQDEVNTQFFSPRSIAPPSVSELVPIAPPAYTSVQVSNLPPDRSRMLPPSVSNSGSVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWY2</accession>
    <name>A0A8G1QWY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_80736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513080.1">
        <property type="nucleotide sequence ID" value="XM_025665687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWY2"/>
    <dbReference type="GeneID" id="37169089"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="107" mass="11757" checksum="12461F5ECE3E62EF" modified="2022-01-19" version="1">MHRTINLVIVFRPPSLAAPGSLGRPCFFSLPFSFFLPLFLSLWILISPAATVPSNLAPMPSGRGHYKKKKQKKEETRRAGGKKKADLNDLLMNALSISPGLAAIIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXJ7</accession>
    <name>A0A8G1QXJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_450894</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514168.1">
        <property type="nucleotide sequence ID" value="XM_025660475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXJ7"/>
    <dbReference type="GeneID" id="37163877"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22881">
        <property type="entry name" value="Mdv1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000404">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000881">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="316"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="358"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="433"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="538"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH56246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="656" mass="72390" checksum="4962620603419224" modified="2022-01-19" version="1">MDKHRRRDESPSGLSDIVEPDGLLGTGITSRHIEAFGRKVTSTAGHLMGPAPDSSSGGHYHTAMADIQRELRHPNTQRKVFSLTQTTPTDLVRSKLSTTEIQSRAISSLPDELLANIPDDSSSYSLFQGFQASQDDIEYRRAHRRRSSKSKKLLKDGETHGALPSAPSDLKKERDLLSRRMELMGVRKNMCSSEIHDIDNKIANLHNMRKIVLDRLAGLEMEEADLEHELNEIENKLEDIQEEQEAEVPPPATPKSSEANDDSIVSEDPAMGASFMSESIYQKIPSPKSVKQRSIRKRSMPVLHEHFAPGSEIKEMPAHSDMVTAIDFDYPFGTMISAALDDTVRVWDLNVGRCVGFLEGHNASVRCLQIEDNIVATGSMDASVKLWDLSRARTTTRDNRVTRREDDEESAQADDASMASHSTTLEDCYVYSLDAHVDEVTALHFKGDTLISGSADKTLRQWDLVKGRCVQTLDVLWAAAQASTLGSETTWRPSGRLPDASADFVGAVQCFDAALACGTADGMVRLWDLRSGQVHRSLVGHTGPITCLQFDDVHLVTGSQDRSIRIWDLRTGSIFDAYAYDKPITSMMFDTKRIVAAAGENVVKVYDKADGHHWDCGAGVGVDDSGPQPATVERVRLKDGFLVEGRKDGIVAAWTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXP3</accession>
    <name>A0A8G1QXP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_138256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511982.1">
        <property type="nucleotide sequence ID" value="XM_025654054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXP3"/>
    <dbReference type="GeneID" id="37157456"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="224" mass="24850" checksum="B7165861D1ADAFB9" modified="2022-01-19" version="1">MAALSRLNGQISTFLAVGFLASWAFTSLSLTTINVLNTESTFTAQAASISLLTFLVCRLLVRLQPVAPTEERTIAHLLATADNGSRRGALIFISFCRTWLYELLTKGLLLLLLTFFGGVMATVIYNDPNFSENWQTEPVSDQPQTTTALAEINDFKEKAGFDPTQLFRWIPPQAVVYFIALVWFNFISLGLYILGHALKAFCRILGFTVTRTTSKDAHTVKGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY74</accession>
    <name>A0A8G1QY74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_54240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514513.1">
        <property type="nucleotide sequence ID" value="XM_025665472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QY74"/>
    <dbReference type="GeneID" id="37168874"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="56" mass="6362" checksum="068F3B665DA1DB09" modified="2022-01-19" version="1">METKPPLNRVWKTAIAFFWVRCYSLVVVGKRRKRGRGDGLRGRKIRSKGTGVGSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYB4</accession>
    <name>A0A8G1QYB4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_451173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513866.1">
        <property type="nucleotide sequence ID" value="XM_025660529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYB4"/>
    <dbReference type="GeneID" id="37163931"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH55944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="170" mass="18951" checksum="187A756544A5597A" modified="2022-01-19" version="1">MVDLEVEHASAGLGERVWTQLVARKSWTRGTAFNSLQDPSQETPGLTDGLEFVRVIPTDWPAACPDRHREAIHHLSSCLSFSFSFLSQGGSIYWCYSTATNTTATTTHNLQNIHPSITKKNEEEDSPILPHTNPPMCHPSKPTQYSNLIQSKQSITRIAINFPLPTAHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ34</accession>
    <name>A0A8G1QZ34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine dehydratase</fullName>
            <ecNumber evidence="12">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_459807</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="12"/>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514978.1">
        <property type="nucleotide sequence ID" value="XM_025661674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ34"/>
    <dbReference type="GeneID" id="37165076"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04906">
        <property type="entry name" value="ACT_ThrD-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04907">
        <property type="entry name" value="ACT_ThrD-I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1020.10:FF:000001">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000008">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="entry name" value="Biosynthetic Threonine Deaminase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006674">
        <property type="entry name" value="PRK09224.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="14">
        <location>
            <begin position="389"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="ACT-like" evidence="14">
        <location>
            <begin position="485"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH57056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="565" mass="61566" checksum="88FE321D46A2EBE8" modified="2022-01-19" version="1">MPGEVTENGVPYPVATKLDNLTLNERSAAPSPTSDKVDGQERSTVDYGIPDAFLLPNGTPDYLRLILTSRVYDIIEETPLHHAVNISNRLECRVLLKREDLLPVFSFKLRGAYNKMAHLTHEQRWKGVIACSAGNHAQGVAYSARKLKIPATIVMPSGTPAIKHLNVARLGGSVVLHGDDFDAAKQEAYRLQEQHGLTMIPPFDDPYVIAGQGTIGMEILRQANLQKLEAVFCAVGGGGLIAGIGVYLKRIAPHVKIIGVEAQDANAMAQSLDSGSRVFLKDVGLFADGAAVKSVGEENYRLAREVIDEVVQVTTDETCAAIKDAFEDTRSIIEPAGALALAGLKKYATNNPSPDTSRELCAIASGANMDFDRLRFVAERAALGERKEALLSVRIPEKPGAFAKLVEVVLPHAVTAFSYRYARDSSADVLMGISLSAATGRDDLAKIISQLVRGGMDTKDLSDDELAKRHLRFLVGGRSDVADERLFMFEFPERPGALAKFLTTLRPNQNISLFHYRNYGGDVGKVLAGIQCPENEKAELEAFLSDLAYPFTEHTDSPTYKTFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ56</accession>
    <name>A0A8G1QZ56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_425851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513211.1">
        <property type="nucleotide sequence ID" value="XM_025658094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ56"/>
    <dbReference type="GeneID" id="37161496"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000013">
        <property type="entry name" value="Proline dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF30">
        <property type="entry name" value="PROLINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="133"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH55289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="478" mass="52671" checksum="CA5965BF8200D45A" modified="2022-01-19" version="1">MKAARRPMRVLSSVPSTYSSARYVSRTSNPKSSAAASTPTNNLLQQQAAVPSNDASGSPLAKLPISSVLRSLVILSVSSSTLLLKPCIFALSTLAHPKTPVLDVAKNPLLNALVKHTLYKQFNAGENKLEVQQSIQAIKQLGYRGVLLGYAREVLVGEGNVDPRDEKAARAEIQTWLDGTLQTVDMAQEGDFVALKFTGMGTQVLEFLQKQAAPSEFMDYAITKVCDLAISRNVRLLVDAEEQAVQLGIEKWALKYQKYCNAKTPGHAIFYNTYQAYLRSTPATIAKHLEVARQEGYTAGVKLVRGAYLKTEPRHLIWAEKEETDACYDGVVEALLTRRYNSMLQPASEEHKTELPPVNVIIATHNRDSVRKAHAIRLQQAARAEKQGVDLSYAQLQGMADEVSCELLQGFSSTDGPASQETPNVYKLLTWGTVKECMGFLMRRAVENTEAVGRTKQSQEAMLGELKRRARRVFGLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ96</accession>
    <name>A0A8G1QZ96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Endonuclease III homolog</fullName>
            <ecNumber evidence="15">3.2.2.-</ecNumber>
            <ecNumber evidence="15">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="15">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NTH1</name>
        <name evidence="18" type="ORF">BO85DRAFT_374153</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="15"/>
    <dbReference type="EC" id="4.2.99.18" evidence="15"/>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ96"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000027">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000014">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HhH-GPD" evidence="17">
        <location>
            <begin position="203"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH56668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="426" mass="47201" checksum="C54AE2F0B7B40043" modified="2022-01-19" version="1">MRTSRASKETAKVLQALSPPARRTTRSSAQAASCLQGFAFGGAPAPDVSVSDDDTSSLSSVPTVDIEDIMEPPAKRRKSALSATSTRANARSSRRATPIKEETPIKEETLVKAETSVEEAPVKKEPLEKPSKARRTPARKIKTENGAYSMQPPSNWETMYDMVKKMREANPTAPVDTMGCAELYWRASSPRDRRFQTLVALMLSSQTKDTVTAVAMQRLHTELGDQSTSIVKKEPEEYDWKPTDQVKDSTLNLENILAVTPERLNELIAKVGFHNNKTKYIKAAAIILRDQYDSDIPSTATELMKLPGVGPKMAFLCMSAAWGKHEGIGVDVHVHRITNLWGWHKTKNPEETRMALESWLPKDKWHEINKLLVGLGQTVCLPVARRCGECDLAGTKLCKSEIRGLVTPKRDAAVKQEGPKVKVEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZC1</accession>
    <name>A0A8G1QZC1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_440056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513678.1">
        <property type="nucleotide sequence ID" value="XM_025658749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZC1"/>
    <dbReference type="GeneID" id="37162151"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF8">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="6"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="393" mass="44299" checksum="82CAFB686AD8242A" modified="2022-01-19" version="1">MSENHAIVFGASGVNGWAVVNALLQGYPSEDAFASVTALTHRLLSLQDTLWPKSPKLDLVSGIDLLADAKRETLEDELKRKVANADKITHVYFFAYIMDADPKAEVHKNTELLKRSVLAIQNVSSHLKFVVLGTGAKSYGSYLLEQFPFRDQVPLKESLPRMPEPFASQIFYYHQVDQLSWISQGKSWSFCELMPDLVVGFVPHNNYYCMAQILATYLALYAKINGKGSEVVFPGTQRSWECLSQDSSQDVIAKTAIYASLHPQETAGQRYNVTDSARPTSWSEKWPVICEYFGLRGTGPRDGVAGPVPNEYLVEHYNEWRELEKEEGLKTGRVGNNKSYGDFARIMMTLCDLDRQLDMSKTHAMMGSAKVEMDGRGAWWTAFDRFRRAKIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZD2</accession>
    <name>A0A8G1QZD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_451832</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512867.1">
        <property type="nucleotide sequence ID" value="XM_025660682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZD2"/>
    <dbReference type="GeneID" id="37164084"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH54945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="460" mass="49942" checksum="24EEB32879E1F82D" modified="2022-01-19" version="1">MGKEDKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDQRTIEKFEKEAAELGKGSFKYAWVLDKLKSERERGITIDIALWKFQTGKYEVTVIDAPGHRDFIKNMITGTSQADCAILIIASGTGEFEAGISKDGQTREHALLAFTLGVRQLIVALNKMDTCKWSEDRYNEIVKETSNFIKKVGYNPKGVPFVPISGFNGDNMLEPSPNCPWYKGWEKETKAGKVTGKTLLEAIDAIEPPVRPSNKPLRLPLQDVYKISGIGTVPVGRVETGIIAPGMVVTFAPANVTTEVKSVEMHHQQLKEGVPGDNVGFNVKNVSVKEVRRGNVAGDSKNDPPLGCESFTAQVIVLNHPGQVGAGYAPVLDCHTAHIACKFAELLEKIDRRTGKSVESAPKFIKSGDAAIVKMIPSKPMCVEAFTDYPPLGRFAVRDMRQTVAVGVIKAVEKKEGGSGKVTKAAQKAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZT4</accession>
    <name>A0A8G1QZT4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_54036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514504.1">
        <property type="nucleotide sequence ID" value="XM_025665469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZT4"/>
    <dbReference type="GeneID" id="37168871"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000316">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034383831" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="22"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH56582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="538" mass="59147" checksum="3041B4F7B7213AB6" modified="2022-01-19" version="1">MILFHLAPFFFLFGLVVSSQNPTVDLGYTKYKGKSLPNGISQWLGIRYAAAPTGSLRFSAPQDPDSVEGVQDAFKHGPRCVPTSQYPTPAGTSEDCLFLDVYAPSSVKDITRLPVFVWIQGGGFNANASPNFNGTGLIEAANMSMVVVTFNYRVGPYGFLSGSEVLQGGSVNNGLKDQIKVLEWVQEHISKFGGDPSHVVIGGSSAGAASITLHLSAYGGKDEGLFHAAAAESQSFAPMLTVNQSQFAYNNLVIRTGCASDPDTLACLRRLNTTELQRVNINTPLPTAQQAPLYMYGPVVDGSLIPDYTYRLFQQGKFIKVPVIFGDDTNEGTIFVPKTTSTVGEADTFIQDQFPNINFTHLTKLNNWYLNENQTREFPKSSPYWRPASTAYGEIRYICPGIYMSSVFSGAGVNSWNYHYAVQDPAAEASGRGVSHTVEENVIWGPQYVSGTPPASYSTTNAGIVPVMQGYWTSFIRVFDPNPLRYPGSPEWETWNNGHGADYRRIFLRTNETRMETVSEEQRERCDYWSSVGPDLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R044</accession>
    <name>A0A8G1R044_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_61120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514113.1">
        <property type="nucleotide sequence ID" value="XM_025665527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R044"/>
    <dbReference type="GeneID" id="37168929"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="65"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH56191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="250" mass="26105" checksum="7B551C3F671CA9A9" modified="2022-01-19" version="1">MSAKLDKSLDEILVSRRQGARRRARRSAPKAANTSVPVGGVKKTTKAAKAPGKAVQNGHPVSTESKIMVSGLPSDVNEANIKEYFTKSAGPVKRVMLTYNQNGTSRGIASIVFSKPDTAAKAAKDLNGLLVDGRPMKIEVVVDASHAPEVPAPKPLGERVAQTKPQPKPATATKAAAGAKGRKGRARRPNGRGNRPKPKTVEELDAEMVDYFSTTNENAGPAEGNAQANGAAPQQPAANGGEDLGMAEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0D8</accession>
    <name>A0A8G1R0D8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA adenine-N(1) methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_373890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514850.1">
        <property type="nucleotide sequence ID" value="XM_025656103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0D8"/>
    <dbReference type="GeneID" id="37159505"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF1">
        <property type="entry name" value="25S RRNA (ADENINE(2142)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH56928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="286" mass="31793" checksum="695EA96B4F677094" modified="2022-01-19" version="1">MKTLRLTLKRPALLSRTRPPTVRAKHAALSAKATRNLIRSHHRLLKAHAQAVRAGDDVLVAKIEAQIRENGGLESYQLASKLGQSLDRGGDSSKVLVDWIAPRLLPMANTPYKLRVLEIGALSTKNACSMNKSLDVTRIDLNSQEPGILKQDFMERPLPQNEFDRFHIISLSLVLNYVPDAAGRGEMLKRCISFLTTSPPSGSSLDVTPSLFLVLPVSCVTNSRYLTESRLQDIMSSMGFALAKTKQTSKLIFQLWDQVGDYNAKPFKKEILNPGKTRNNFSIIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1V0</accession>
    <name>A0A8G1R1V0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_477660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515940.1">
        <property type="nucleotide sequence ID" value="XM_025662843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1V0"/>
    <dbReference type="GeneID" id="37166245"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000002">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="9">
        <location>
            <begin position="189"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="8">
        <location>
            <begin position="381"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="176"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="448"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH58018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="489" mass="54461" checksum="ABEF25D15F499A43" modified="2022-01-19" version="1">MVLDYSKWDALELSDDSDIEVHPNVDKRSFIRAKQAQIHQQRAQRRHEIETLKYEHIVNNGLLSRIDKLLTALKQNEGSKSVEEVIFQNLMEFAGNPSDDHPPAAPAGVHTQEKEQPKYSQMMSALVDQVKKEMGDVSSENLYQEYIKGVQRHNDKVQGLQKELLQRLAQLEKEEGSKITSEGLHEGFNTSHIAKPGEAKGQKTETVELLNPGASTAGSSQQAAAPAADDDDEEEDPENVKASELAKRFAKINRNDYRALLQFISENPQIVAEKETDGLLVEAFNSQMEGKEDYARTCVHQGLLLQYCRSLGRDGISLFFKRITNADHQAGTLFRNDVNETYHKIKTRAAELAKDGSASNDPAGVEQIQLHAVDPNTKITINIPSAEGDDPVEVEARKVYESFSKDLQKALASESLDEVNKVLGKMSVEEAEDVVEKLGQSGMLSLEEGIVDATTEEGRKKLEEIEAENKREREEQEVGEPGGDITELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1X1</accession>
    <name>A0A8G1R1X1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_373279</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH56997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514919.1">
        <property type="nucleotide sequence ID" value="XM_025656074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1X1"/>
    <dbReference type="GeneID" id="37159476"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eIF2g_dom_2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="G_TR_2"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="83"/>
            <end position="291"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH56997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="513" mass="55948" checksum="6B262DC598298EEA" modified="2022-01-19" version="1">MAANGDFSDDESQPGSPMLDANGHDDIEEQEPLDQESKPLKSAMKKAVPPPQPKRPELPEQPNPETLDLSTLTPLTPEIIARQATINIGTIGHVAHGKSTVVKAISEVQTVRFKNELERNITIKLGYANAKIYKCDNPECPRPTCFKSFKSEKEVDPPCERDGCSGRYRLLRHVSFVDCPGHDILMSTMLSGAAVMDAALLLIAGNETCPQPQTSEHLAAIEIMKLSHIIILQNKVDLMREDGALQHYQSILKFIRGTVADGSPIIPISAQLKYNIDAVNEYLVSHIPVPVRDFTASPHMIVIRSFDVNKPGAEIEELKGGVAGGSILTGVLKQNDEIEIRPGLVTKDENGKIQCRPIFSRVMSLFAEHNDLKFAVPGGLIGVGTRVDPTLCRADRLVGFVLGHRGRLPAIYTELEVNYFLLRRLLGVKTADGKQAKVAKLTKNEVLMVNIGSTATGAKVVGVKADAAKLSLTSPACTEVGEKIAISRRIEKHWRLIGWANIVAGNTLEPILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1Y2</accession>
    <name>A0A8G1R1Y2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_449747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514934.1">
        <property type="nucleotide sequence ID" value="XM_025660222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1Y2"/>
    <dbReference type="GeneID" id="37163624"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="76" mass="8381" checksum="2A927F4E7995434B" modified="2022-01-19" version="1">MSSNSANLSNSPPPSVGDRRRSTGHGASSLFESLTSQKRNSTDQTLNTRRESWNEQGQQGGFFAKWWDGYTRGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R212</accession>
    <name>A0A8G1R212_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_448594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516508.1">
        <property type="nucleotide sequence ID" value="XM_025659976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R212"/>
    <dbReference type="GeneID" id="37163378"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="297" mass="34134" checksum="3C231766577C331E" modified="2022-01-19" version="1">MASRDVQTSEFFQRKVDELVRKYDRITEPNAVLQAILQDPESMRSLVDAVQRQASLVRHRSRNVEDAEITVFDNALMILSNGGHDTQDVGALELYLAEYLGVCTFSPIAHAKQALHDHDILQDTVTRATASPSITDEATATEEQPQTPEQALKTLVQDNEHSRRLQHILPPRPPPTLEELRRREQVERLIQMYEKAKAEYSKKDPEDIDISLAKYFRDTSENTLHFLRVNDMSDHPLIPDIENSFERAKGKAAQLAGRGRHFDEPRATTSTHNHPSKKRRGRRHRYREVDSYRPGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R246</accession>
    <name>A0A8G1R246_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial distribution and morphology protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MDM34</name>
        <name evidence="13" type="ORF">BO85DRAFT_291913</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="10">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MDM34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R246"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03105">
        <property type="entry name" value="Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="12">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="329"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="485"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="534"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH58014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="563" mass="61454" checksum="96D60CF412FBE517" modified="2022-01-19" version="1">MAFNFNWSPLMADASFYTRAQELLTAALNKSPKPPIIVDDIHVTELNLGSIPPELEILEIGDLAEDRFRGIFKMSYTGDAFLTLKTRVQANPLNTYLLTRPSFATPLPVAAATPLTIPLQITLSDFKLSGFVILVFSKQKGITVVFRNDPLESLKVSSTFDSIPFVRDFLQREIEGQLRVLFMDELPAIIHRLSLRLWVPEYRAGEEMANRATNTAGEGPGQDPLASPPQDPVDAQGNALDESEIASLSLDSSVETHSLFSQKNLLRLAALTDSQRTLSLFTPSIQEVVYRAWTSPSDAGEVSGGVMSPLSPALSRTHSQVGGMSSFQDTASMVSSQTRSSTNTHTFSSYGLSLGAGRHSKSNARRRKKRVVDLRRPKAPEDAASVSGDSTYTETTSAPSVCSAPLPVVSEQTDDPVTPPLSPNSELHLPTVPERHRLSISRQMPRRDIATEMLRETGESSAQPVNHSAVDVDATPRVAVHPYIPAQHDNEKGEASASRQLPSKALPFSDTKPTSSIVDQALVERLAGEIARRMREEKLTPGNSCSSFWDRLSHDDAPPAYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2S3</accession>
    <name>A0A8G1R2S3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_521679</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513762.1">
        <property type="nucleotide sequence ID" value="XM_025665211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2S3"/>
    <dbReference type="GeneID" id="37168613"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000184">
        <property type="entry name" value="Mitochondrial carrier protein, putative (AFU_orthologue AFUA_6G12900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="100"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="191"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH55840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="295" mass="32005" checksum="7FC9235E9BE9AC6F" modified="2022-01-19" version="1">MSSDFWAGYLSGAIGIIIGNPLDVIKVRLQAGRTPDIAASTTPQQLSRFDSATSLVRGAAAPILGYGALNALLFVAYNRSLKFLDSSIIDPTNPQGVSLSKIWLAGAAGGVASWTVSSPTEFIKCRAQLDSRPGVSSWTVAKDIVRTRGWTGLYFGGGVTCARDAIGYGFYFWSYEYCKRLTASNEDDATMTATKVLLCGGIAGIVTWASVFPLDVIKTRLQARTIELSPEHRPLMQPSAKPYTASSIQIAKEAYLNEGLKAFYRGLGVCSVRAFIVNAVQWATYEWLMKYLQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3C5</accession>
    <name>A0A8G1R3C5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_337617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516750.1">
        <property type="nucleotide sequence ID" value="XM_025655450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3C5"/>
    <dbReference type="GeneID" id="37158852"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="163" mass="18041" checksum="5CF0C13AAFB0F0C8" modified="2022-01-19" version="1" fragment="single">RVIDTHKRCVILAPQDCKYATLSYVWGRGGDLIQAKLGNIDDLGKKGSLADDSCLPATINNAIEACLSLGISFLWVDRLCILQDDEPCKKAIQLNAMGKIYNQSYLTLVAMAGSDAHYGLPGTNAQRRSPLWTGQTQGIYLLKDIDAYDKICRSSKWQTRGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3S7</accession>
    <name>A0A8G1R3S7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_478138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515641.1">
        <property type="nucleotide sequence ID" value="XM_025662880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3S7"/>
    <dbReference type="GeneID" id="37166282"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="257"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="486" mass="56534" checksum="54F9529412878D2D" modified="2022-01-19" version="1">MKPQMSYDDVAWAQSDEISDTWVNKLFNIEVKKAIARFILTHDSGDDPEFSIIDIGSFNIVLQMKYTQGATDIRFSQPGAIIFPEEKTRNEIALMRYLSNRTSIPVPSVIHSGTRDDSPLRLSPFIMMSHIQHTTIMYAALNAPSCPVDERGYLNPDINEEDLWKLYAEQAKILLNLAKPEFSLIGSLVQVDNCTWEIASRPLSMNMNELVRLGTLPRSKLPPLDATFKTTSSYIEALAQLNIQHLIHQRNDAVESADDCRRKYIARQLFYKLAKEKRLFGARHERGPFRLWCDDLRPGNILLNDDKRVTGVVDWEFTYAAPVEFSLAPPWWLLIENPDEWSEGIEDWKRIFGQRLKTFLSALRHCEDAEGLHRDFRLSDKMKKSWETGDFWVVYAVLHSFAFDAIYWLEIDKRYYGPTETDDVSEAWKERVKLLDESQRDEMEQLVVKKLAEMKNKVLAWDPDEYTEEYYQVLKRKRQEAASEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3V1</accession>
    <name>A0A8G1R3V1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_469610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514272.1">
        <property type="nucleotide sequence ID" value="XM_025662340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3V1"/>
    <dbReference type="GeneID" id="37165742"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="36"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="368" mass="41671" checksum="941F32053A19F8E3" modified="2022-01-19" version="1">MTDFGDFASTEDEEIELDEFAEPWEKYDRKILNERYLIEHKLGSGGFSTVWMALDLQENKDVAVKVLCTGDYGGIELRIQDEIVQSVQDRSHLVTYSDTFILKGSEGHHRVMVFPLMGPCLDRYTLTNLAISTRMSAAKQLLQALEALHNAGIVHCDLSERNCLTVKYELLTWLSKRAIQDVELWKPGELVRPIQVPETLCIEDFYLADFSLAMKVGDPVAQPGDLSLCFCSPECLHGEAPSFVCDMWSYMVNFVELYQGGRPFHDGYIGGVLTTITARLGPLPEQWKGSYIYDDCLDSWYDQNRTPDKNNTLASGLARYRPDADPAERELVLSVMQKVFLYSPEERLNATQLLADPSFKALMARYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R414</accession>
    <name>A0A8G1R414_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_399680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514362.1">
        <property type="nucleotide sequence ID" value="XM_025657108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R414"/>
    <dbReference type="GeneID" id="37160510"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2210:FF:000002">
        <property type="entry name" value="ATP synthase subunit 4 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0138">CF(0)</keyword>
    <keyword evidence="4 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH56440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="247" mass="27011" checksum="FBB798BDFB672216" modified="2022-01-19" version="1">MASRLAKSALGAARLRPTLPTRNVAPITATLTASRSASNVPTEDPKKKAQSIIDALPGNSLVSKTAVLSAAAGISIAAISNELYVMNEETVAAFCLLSVFTAVAKYGGPAYREWAEGQVQKHKDILNAARADHTNAVKQRMENVQELSSVVELTKQLFAVSKETAQLEAQAYELEQRTALAAEAKQVLDSWVRYEGQVKQRQQRELAESVIGKIQKELENPKVLQQILQQSVADVERKWTTCVPHDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4N8</accession>
    <name>A0A8G1R4N8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 30 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_448302</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517331.1">
        <property type="nucleotide sequence ID" value="XM_025659907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4N8"/>
    <dbReference type="GeneID" id="37163309"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.60:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03009">
        <property type="entry name" value="eIF3j"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="215"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH59409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="254" mass="28260" checksum="4D3BCC2B9EB28C6F" modified="2022-01-19" version="1" fragment="single">MAPSKWDDEEESVSPPPVVARRKFDDEEEEDVLDSWDAAEDSEVEREKAAKAAEAKAKAEAEAAANKKSKAQRIQEKKAQRKADADAETSDDSDEDEAERRARLRKTEKDADLKHAEDLFGDIDLNRMRNRSAPKAVVISDSADPTQAVDLSAMPLFKPATKDQFTRVTTTLIPLLTTQSKKPQYALWAQDFVKQLVKDLPSGDVKKIASSLTTLSNEKMKEERAADKGNKKTKAAKTKVSLVTSRENRIETNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4T8</accession>
    <name>A0A8G1R4T8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_368781</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517114.1">
        <property type="nucleotide sequence ID" value="XM_025655883.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37159285"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="30"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="934"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="993"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1149"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="936"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1000"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1161"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1206"/>
            <end position="1220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH59192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1328" mass="148781" checksum="783728E6209DFCE0" modified="2022-01-19" version="1">MDGGDSNDSALSLLDEKREKHLIRKIDLHIIPFVVLLYLFSFLDRVNIGNARLYGMEEDLGLVGDQYQIAVSILFVTYCLFEVPSNLVIKKLRPSRYIASISVIWGIIATLTGITQNYGGLIACRILLGVVEAGLFPGMVTYLTIFYSKREIALRTGYLFSSAAAAGAFGGLLAYGIGFMDGVAGLRGWRWIMIIEGIPTVILGGLSWFFLADDLDTAYYLDDEEKALVVRLRRRDVGQTSSAQKFHWADVKEGALDWRIYAFCIAQFGVDTMLYGYSTFLPTIIQGMGSWTTPEVQALTIPCYAVGAISYLIIAWASDRIQRRGVFTCIFAAISVVGYGILISDSSSGVHYFGALLIALGLYVAVGLPLAWLPTTLPRYGKRTFATGLQLTFGNVSGVMSPFLYKTNEAPRYVRGNAVTLSLVGFAGVVYGLMWWYYHGKNKRREQGLEDEKIVGMSEEEIEEMGDRNPRWRAWIQSPCIEQHNDWNLYQHLGGYGPWVEKTAEDDEIQGNDVPDSCTVDQIHMMSRHAARYPTRSAGNRHLALLDRIHKAGIPLNGSLSFLNNWTYITSNPERDFEQLTTTGPYAGTHQAFETGVRFAAHYGHLIPSDANTKFWASDSKRVIETAQHFASGLFGSDWEKVGKAALEIIPETFDRRADTLTPGDTCLKYLEDEVRGHDNGINMLTLFQQAYIPAIAERLLVEEGNRELEGFTNWEIFSMQEMCGFETTVRGSSPWCDVFTREDWKNFEYGRDLVHYYRGGPGNPYAGAMGWLWLNATANLLREGPKAGSMFFSFVHDGDIAPFLTALDIMKDAKYDPFLPVTHRAEDRIWYTSTVMPMGGRVTLERMTCSPTDPVHSMNETFLRIDINGKIVPLPYCKSGPDLSCPLMEFIGHVDRRRIEVGEFGDVCGLDGDSKSYTISSFPPKQLQLNLTHRLSSESRNPRRPPEESGPFGKRRNARYEHTRSRTRTGTPAAKRENPNVAEFGRLFAQQQEEEKARSNTLPKSSSASNLDNARKQQTEKVATECILYGYKSKDFEWKVIDKYERISRGFICEDYPRTDPNALNGYSQLLSGGDVVIRANLSADANRKSKRYAGGFHWIKVTFDSTTAADRACFYSPQEIDGHLVFCELYHGQGPAEDAPIVQGSTEATRLQSKAAPRTLTSSHSTSFLQPKDTATKERHTLPRSFASNNLSSILDAHEEESQESSSTPTASSATATAIEQPAPLQQRTVVKEPKPESDFMTHIPTVRRTKLRPITEALPPQPTVTERVLRSIPILSWFTGDIVGDGPQLREDGTFDFDKSNTYWKFWYMVDRVLGTDICGLKEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4W6</accession>
    <name>A0A8G1R4W6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_519110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517250.1">
        <property type="nucleotide sequence ID" value="XM_025665020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4W6"/>
    <dbReference type="GeneID" id="37168422"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="277" mass="32183" checksum="5333F793248826ED" modified="2022-01-19" version="1">MAVLTLEGGENGYNRAIRGNYSRLEAFRIIQECLAPEYTVREQTAQALHNLLPPPDDPTYPGGADLFGDLIHELSQQVEYDNVAQDRYVQVIQRLQDSDRVKKYIPQPEGVGGYGRYEIMPQLMRNLGQYSAQRMDRNGNRNYFVNVRAFIARLCRVGALQGQAWLVNEMKAAFEETLPEQFHVVSIMGAAVIIEFAGGWLYEEVVRAPKLDEINDNPLWATGYYYNGPRYGIARWNHWQRLFRWAEQTMPLDRESKRLIFYAEWYMHGMSRSLQPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5C3</accession>
    <name>A0A8G1R5C3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_368097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517706.1">
        <property type="nucleotide sequence ID" value="XM_025655849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5C3"/>
    <dbReference type="GeneID" id="37159251"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="131"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="405" mass="41974" checksum="7FFF98C42DAB23D2" modified="2022-01-19" version="1">MKALTSALIGAAALAQNVNSSPLSGAAGLDFPNVTGLANPTVHVSNGGSAHCVSGIVKVNATTDKNLKFAYNLPSNQSQVTQTLVSLWSSGGDGYLKSLTSGTQRVSGSYDIEATYCLPAGKTSKTTKVQILTHGIGVDRHYWDFASGYSYIDTAAAAGYATFLYNRLGVGASSKEDPLNVVQSPLEMEILKTLASKLRQGTLGDRAFSTVVGVGHSFGSILTQGVTAAYPKTLDAAVLTGFALDSNGLPGFGLGLNAAIASETQPYRFSGLSAGYLVAGTAVSNQIAFFYDPGYDPEILSLADATKGSFTLGELFTLTHVVNATSEFQGPVAVVAGNEDLPFCNGNCSSPTNILAGHVPAPYPEVSEAKTATYVAPAVAHALNLHYAAPGAFDFIQDSLKKHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5P2</accession>
    <name>A0A8G1R5P2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_297923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516122.1">
        <property type="nucleotide sequence ID" value="XM_025655318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5P2"/>
    <dbReference type="GeneID" id="37158720"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07262">
        <property type="entry name" value="VOC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF3">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G06020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH58200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="604" mass="64215" checksum="AFCA26DB08DA4538" modified="2022-01-19" version="1">MPVSHLTLTVAHLPTSTSFFLSCLQPLGYQFIGRHDDYIGFGQKTGEPADFWITEQKPGVPAGAAHVAFPAASKDAVSTFFINALKAGGKIHGEPKQRDSDSGYYSAAVIDFDGNSIEAVYRPSISSARSEVRSVAKSVAKSEARSEARSELTRPALALLENGSVVSKATSKASSVRPESVAPPKSEARSYVSRSSTAVDRAPPPYERAPSTISVSRESQQPREMQPAPSPTYIVHHTTHTTTQQKTDDGKTAKTIVGTLIGAAAGAALAYAMTKSDSSEQHSEGSAPPPQYSPRDIVQMLSPSQAPSQAQEEYPGYKAIEAPPPRSVYSSRSDARPGLTRSVTSKNPRADTIYEGTEFVPRGGSVYLDENGRRASEGSVYTTKDIPLRAIEYAPPADSRGYQSTLVSSFREDKSRAMDGGSVYSSATVRPPSKANYQESHHSSHHSSHHSYHSVSRSQAGSTASSNRTARQVPLPEGSIASFASYRSGAKSGVSAREVPLPESVVDLDVQSHVTPDDSISQVDDSRRSSYSHRSHASKSPSKVSKHSKFDEPVKPSDSVSQVSTNVSRASQRTMKAGGSGGGGSVAPSKAASKVSRRTASQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5V3</accession>
    <name>A0A8G1R5V3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_367181</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517699.1">
        <property type="nucleotide sequence ID" value="XM_025655811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5V3"/>
    <dbReference type="GeneID" id="37159213"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="7">
        <location>
            <begin position="208"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH59777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="284" mass="32006" checksum="C0129DA3339BCC01" modified="2022-01-19" version="1">MALELKEKGNQLFKEGDYNGAEEMYSQAILKNPKEPTFFSNRALTRIRLENWAGVEHDARAAIDLYGAKSPTSLKSSWYLAQALLGLQRPQEAYDVAIEAYKASLAAKNIQTENLSRTVLRAKQAIWAAKETARIRELDETLASVEGLIEAEVERGVSELKARLEKGEIGEIGFREDEREIREDAERKVQRVREVFGIASEGKVVERVVPDYLVDGITFEIMHDPVITPSGTSFDRVGITKYVEQAKVDPITRVPMTVNDLRPNYALKAACEEFLDKNGWAVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7N6</accession>
    <name>A0A8G1R7N6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_488058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516177.1">
        <property type="nucleotide sequence ID" value="XM_025663499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7N6"/>
    <dbReference type="GeneID" id="37166901"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="104" mass="11289" checksum="D53153C8223035DF" modified="2022-01-19" version="1">MEPIRGGVHVTATGDGEQKGQSVPCISRQIFWLRFAAAMDLASDVGVRHSVVLSSLEIRHLVDFSPATTSIAREIRLCVIAIVVGWTTSRVVSALLNRRSSSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R814</accession>
    <name>A0A8G1R814_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_414636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519161.1">
        <property type="nucleotide sequence ID" value="XM_025657655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R814"/>
    <dbReference type="GeneID" id="37161057"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.70:FF:000008">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="371"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="530" mass="56908" checksum="E3789DE54C3AA25C" modified="2022-01-19" version="1">MATGSHMHNLTTLIKRLEAATSRLEDMAMSLDDPNSPKTIAPPAVPEAATPEPPKSAPAAAPAPPPIPPQIQDFDTLINEDVRNFVELGQKINGLVGEQSKVVLQAFEAERTYLLVSTKARKPEQQPPELMTGLHNASDSINNIRESNRASPLFNHFSAVAEGIVALGWFFADKPADFVTEMAGGVEYYGNKVLKEYKEKDRTHVQYIQAYYQIYKSLAAYLKKHYPKGLTWNDKDGIDAQEALRQVKAGSSGPAAGGAAPPPPPPPPVPTLNVPGGVPPPPPPPPGVPPPPAAAPAAPDMSAVFDQLNQGEAVTAGLRKVDKSQMTHKNPNLRASSMVPDSPTSGGSAVRGKSPAPSKKPKPESMRARKPPRKDLEGSKWFIENFDNPGEIVEINAQQNHSILISRCNKTIFKINNKANAISIDNCTGLSLIVDSLVSSLDVIKSPKFALQIDGVVPTLLLDQVDGATVYLGQQSLATEVFSSKCTAVNIMLPPKEGTDEDTKECPIPEQIKTYVKNGVLVNEIVEHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R883</accession>
    <name>A0A8G1R883_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_184573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518929.1">
        <property type="nucleotide sequence ID" value="XM_025654376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R883"/>
    <dbReference type="GeneID" id="37157778"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="108" mass="13001" checksum="2240DD5116098F8A" modified="2022-01-19" version="1">MRRLRCSRLVPRRIREIRMAFWPLIWLRIVRYGAISCKRRRGRESSYSLSICWIGKDRWMEDIRRINTRSLSLILSGSSNNCFHIIFVLVINRFMTSSLSRHVSHHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8Z2</accession>
    <name>A0A8G1R8Z2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_445168</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519690.1">
        <property type="nucleotide sequence ID" value="XM_025659191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8Z2"/>
    <dbReference type="GeneID" id="37162593"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH61768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="112" mass="13413" checksum="762AC1203DB37458" modified="2022-01-19" version="1">MSSAPSAAAPIKGMRKNGKNWHDTKKPFRPTSGMTSYAKRLEARKHHEAVKEHEKELKEEKEAERQAHIQRIKDRRAAKEEKERYEKMAEKMHRKRVERLKRREKRNKLLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9A3</accession>
    <name>A0A8G1R9A3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein phosphatase 2C homolog 2</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_364572</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518759.1">
        <property type="nucleotide sequence ID" value="XM_025655703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9A3"/>
    <dbReference type="GeneID" id="37159105"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000016">
        <property type="entry name" value="Protein phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="366"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH60837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="424" mass="45950" checksum="7CA71063819CD725" modified="2022-01-19" version="1">MGQTLSEPVVDKTSAEGQDECCIYGVSAMQGWRISMEDAHAAVLDLQAKYSDQDEKPTDPDKRLAFFGVYDGHGGDKVALFAGENVHKIVAKQDSFAKGDIEQALKDGFLATDRAILEDPKYEEEVSGCTAAVSVISKHKIWVANAGDSRSVLGVKGRAKPLSFDHKPQNEGEKARISAAGGFVDFGRVNGNLALSRAIGDFEFKKSPELSPEQQIVTAYPDVTVHDLSDDDEFLVIACDGIWDCQSSQSVVEFVRRGIAAKQDLYRICENMMDNCLASNSETGGVGCDNMTMVIIGLLNAEFRGPGIRNQFEENPDDFDMENDRARGFSVRSGRIILLGDGTELIPEQNDDELFDQAEEDQDLVNQVHRDSPDAARNEREGTPGPQSKDTPRTDAAEISESPSTTAEGSSGSAPGTPQKPTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9V4</accession>
    <name>A0A8G1R9V4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_413367</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520200.1">
        <property type="nucleotide sequence ID" value="XM_025657607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9V4"/>
    <dbReference type="GeneID" id="37161009"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="612"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="628"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH62278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="714" mass="80552" checksum="CA1931CE2A0FA235" modified="2022-01-19" version="1">MTASEEASPATRARKIRKVTRACDACKAKKKACTGNIPCGPCSRRHLACTYDSAYNRGVALSPPPSSSRPKNHRPLREHGSSRSNPDPAPGAIQPLQSPSVLRSYWGPSSAHSFLGRVVEDLHASPSKPIAPAQDPDASATVSIFSYGDRVVPEVQLSDFVWPSQARAKSLIRRYFEFAAPTYRVLHQPTIHTLVQRLYQENSEGNRIGSQLDVASQAVLLLLLSTAAMFRVDEDGRMRDADEDGWRNSELYYAQAEHLLSLETGAPTLASVQARFLMVLYLLSSSRAQKAWFVFGTTVQLMMALGLHNRWARRHHEEEEDLVKQECQRRLVWCSYTLDKYLSVILGRPRLWHDEDLDEDLPTRVNDEDLTTRERRLSRRDCVMDAPVFHATLAQILTQAAKEPYVLSGLSDRTEVETIRGLCGKIAKWQAELPPFLSGVIQPSSLVPVFRRQLTVLQLARHHALMFITRPLLLLDYGQMWPEHRSSYRYHLHLCLTAAREALELILSFVREDELFPAFWYSQYIAFNALSIIYLYLIQVRRNRLPSAGLDFVRSPEHTLHADLDEPTLYRLSETAVTHLADATARNAPSWKYSVILQGLRHELARLVSPMDTGDAQATGPNELSHPVSERSPRPTEHSGEMGRREQQAEGNAVRDYDPDPNMLPTIFSGLDPAIDPVLLDPRTQSLLDTFIMGENVVLDFWPQLESLPISYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA50</accession>
    <name>A0A8G1RA50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_135409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520350.1">
        <property type="nucleotide sequence ID" value="XM_025654034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA50"/>
    <dbReference type="GeneID" id="37157436"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="195" mass="22205" checksum="62E0E0AE0E8E52EB" modified="2022-01-19" version="1">MGHDGIWVTHSEHRLELRQSRYAVSPKPCSYFPTTSSLFGLRAGRGLSFSLTILPRPPPQTQQSNKSEEVCMHTGQWFLFRFTFSFIPFFFFLLFILFFSFPPPTAHPSLSLLPTSFPFPIACSLSRTVFPRNSPGLFSIQVLFLSIYYYLSSLPSSLFGKCFKEATWKIIYLAFLKSAIATHFGPVSLPYDVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA98</accession>
    <name>A0A8G1RA98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_445439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519949.1">
        <property type="nucleotide sequence ID" value="XM_025659258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA98"/>
    <dbReference type="GeneID" id="37162660"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="105" mass="11263" checksum="88AE53A8790E18C9" modified="2022-01-19" version="1" fragment="single">MVGVADQWVVAHFSRGFGLVSSSRLLCSGSTVLWCAIGGCALESSDNQLDGVTQCESIMCGHMCVVLYKTSSIAERSARCHGRQTIYPMVTVSAEMSDNPRVSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAG3</accession>
    <name>A0A8G1RAG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_517613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519359.1">
        <property type="nucleotide sequence ID" value="XM_025664921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAG3"/>
    <dbReference type="GeneID" id="37168323"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF6">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH61437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="290" mass="32133" checksum="7BCEAB7D403A3F7B" modified="2022-01-19" version="1">MPPLPTQTHGPPTGHPILIIPGWEMTPETEMHDFEPIFTNIPNSNLHRIYIALPGTASTPARNITSLDDIYHHLVHFIDTTLGDARFMLIGSSCGAYLARAIAQKYVTQIDGLLLRVPLVQPEDGKRDVDSSLEPLIRDEGVMGNLTDEDRTLLGVENGGKVLVQTEGYVGELVRKYREVYVPAEEGADKGVLDRIRWDVGRYRLSEGVLGNGNGGEKLMAPTLVVCGRQDESVGYRDCLGLLERYPRATFAVLDRGTHGLPVDASERGVFGALVRDWVFRVGEWRDSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAK6</accession>
    <name>A0A8G1RAK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_360719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025655562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAK6"/>
    <dbReference type="GeneID" id="37158964"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF45">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH63116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="702" mass="79682" checksum="0DEBC180E9448A2B" modified="2022-01-19" version="1">MPPPEQRASTPTSSRAAGRSPRVLACVLCQQRKVKCDRKFPCANCVRAGAQCVPTLGPRPRRRRFPERELLDRVRRYEDLLRQNNIPFEPLHAPVAEDSRVVESGDNARSEEPNVGEERDVAVKAEPELLEGSQFSDTGEVDSDDDSEEDGNDLTHFQFTLGGNAINKMFDEAYKNNDEGFIFGSRKDNVDLSTLHPDQVRIFKLWQIYLDNVDPLLKVTHTPTLQARIIGALSDLTRISSELEALLFSVYSVAIMSLDDEECRTSFGSPRKELLRGYQFGCQQALLNCNVLRTGDRECLTALFLYLVSVRYETDPRSSSSMLGVAIRIAQRMSIHDEKANTRCGALEGEMRRRLWWSLIMFDNRIGEMSDHKTSMLIPTWDCSKPRNLADNDLQPEMKDLPAAQAGPTEALFITARSELGDFLRHSAFHLEFVNPSLKAVARDTKGDGMTDLERRIEDQYLRLCNPDNPLHYLTIWMIRGFLAKHHLLEEYSNFSPAQHSEAQRNSASSCAMRILESDTKLMKSPLTKRYRWHIHMYFPFPAHLHLIHDLKKRPTQEHAHEMWKAMSENAEIRFEDMHRFHPLSEIVSRDILQAWEAYQAALGELGETVSPPWIVQSARTNFNYPYNDTGSCSAEQPNDPEVAPSLSIPTEHGIPNLLSGMEGFGSAASGFGGYSDIFEQAVLEGDAYQSGWPTMSFYPMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAT5</accession>
    <name>A0A8G1RAT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_515766</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521158.1">
        <property type="nucleotide sequence ID" value="XM_025664806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAT5"/>
    <dbReference type="GeneID" id="37168208"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="11">
        <location>
            <begin position="38"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="110"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="306"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH63236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="388" mass="41748" checksum="6FB683C2AFAE8EEF" modified="2022-01-19" version="1">MSSLSAKRKSAEDASHNDEARTPENSPPRKKLRITRRQKQALIDNLQLELTERARKLRAQYALQANDLRARIERRVNRIPVALRKATMGELLEKHMASVRAQQANLSPRKLLSPAKASRSFRTVSVSPNVRKASAASPSARRVKKQSHGEIYSDKENAPAAGEQLDVLKNPKRRGPGAAAGTSRVVSQEMRGADYRILSPKTSNSRTYPHSPLRASPEKPTNSSYLARPMSPLKPISPLKSTSASIPALADNTRIRPVKSTSTSIKDNRPPSQAKRPASRAATATSKTTRSPLPRPATRQLERRGSVSSSASSGTTVAKPTRTGAGARKATTASTSSATTKKTTVARSQATSATAKRNTTSATSKRAPTPAGGEAAPTAARRVLRKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBY3</accession>
    <name>A0A8G1RBY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_15576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520955.1">
        <property type="nucleotide sequence ID" value="XM_025654187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBY3"/>
    <dbReference type="GeneID" id="37157589"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="102" mass="11477" checksum="03B59988FE0C3CD8" modified="2022-01-19" version="1">MSPNPRIIPTTESTTLPRTHQHQPNDADADAPLHTQSSPEREQEDPSSRILGRSIKPPVVRHYSWSEEDRKHALQARLLETEGREMGFSEVRGHDGGVMGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC21</accession>
    <name>A0A8G1RC21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribonuclease/ribotoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_495321</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521355.1">
        <property type="nucleotide sequence ID" value="XM_025663907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC21"/>
    <dbReference type="GeneID" id="37167309"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF2">
        <property type="entry name" value="GUANYL-SPECIFIC RIBONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034491808" evidence="7">
        <location>
            <begin position="20"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="142"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH63433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="199" mass="20738" checksum="D22D5F218A60D50D" modified="2022-01-19" version="1">MLFSLKPTLFLALALTAVASPIANPTADEPSTLVARGRAKIKDVNCGGEILTKMDISNAIRQSKGNGGGIYPKPFMNYDNFFGASNMQEYPLIPGGTYTGNGAPGKYRVIMNGSNQYVGSVYHPTLTGNTFKKCSNIADSPTTTTTTTTTTRTTTTATAKATTNDSNNSSGNSSGNSGNSGSKSSKKSTKKPSTKTGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC56</accession>
    <name>A0A8G1RC56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_444779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521411.1">
        <property type="nucleotide sequence ID" value="XM_025659106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC56"/>
    <dbReference type="GeneID" id="37162508"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="80"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="315" mass="36109" checksum="17D69A640CE4C728" modified="2022-01-19" version="1">MWLSLIPSIITPDYTWPAPAVTTVQRVTPPVPAVPDANSRWLRGKAHGLLYHFSRCYCYLFGLYFDPHIIQLPFGLVLKWTDRTSVEEVIAMQMARAAGIPVPRVLSCGEHVTPHLTREVSILMTRLPGFSLVNSDDPLEVADEGPWLEELKTCVHAMREWEPPSQDIICSPIGTALRSSRVPDHIMGPFKDHKSFYQHLFAPASQHGFISVDDYNNTFATAKQLQQRPYKVKFTHGDFKAHNILINEDGHLAGFLDWESGGWYPEFWEYTTAMRFGRDSWWYQVAMWMGGDEYREELESDRALNLLTVDSYIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC69</accession>
    <name>A0A8G1RC69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_389868</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520289.1">
        <property type="nucleotide sequence ID" value="XM_025656753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC69"/>
    <dbReference type="GeneID" id="37160155"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF28">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH62367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="833" mass="92897" checksum="CE1F3D44E7668FE9" modified="2022-01-19" version="1">MPNAAAAVSVRQTPPPSRLTGDLDRDHSGDESWSAADSENDRVVQNGSSVPRALKRKRPLTVSCELCKQRKVKCDRAQPSCGWCSRNGQLCEYKERKKPGLRAGYGKELEQRLDRLEEVIQTQARLIETHIIQGQPTRSHDISHQGPFSYSSPSETAQGPSPNNAFYFHDPPSIVPQPRQSEPSITSPSDISVKNTIQNHLASAMSAPVSVPRSTNNVSQANDYMGNESSLKVPVNLYANQEQLLADPELDLPPYDLLYALVDLYFEHINTWCPILHRRTTLDTFFGPSPLEDADRTVLYAIVATTLRFSSDSRLNEQNRKRYHDSSKQKVLLYGLENSSVKALQALVILALDLVGSSNGPPGWKLLALITRSVVQLGLAVEAKSSLIAPSYPSIYTLRAVTLPEPESWIEDESRRRLFWMVYFLDRYSTIATAFDFALDDKDIDRKLPCKDEYFIKNQPVETRWFQRSSDRADYVTRAENVGSFGLYVEVLGILSRIHAFLKRPVDIGALSDVEEWQTTYRKLDSELTSWEFGLPAEYAYENSSRLFNGSKFTKGIHCDWVQLHATYQTAVIRLHSSAAYPTTRSPIFTPSYSASQRCLLAVDNILSVTRFVVDNNMLDKLGPPFAFTLWVSARLLLVHGSTIAHTVSPDILFFVDTLAQMGKHWKVAERYSSILQRVLDEYGEYQQSGVSDSERATPSTVKILADMRRCAFDLDFLISRQPRTSPAGSQPSASPAAVRNPAPNELEYLDVFGFFNVPRVPAARATDILSLDIGDPVNNPMSVNGLTGTGGGGSSSNTNHVVDGSHSNANEFNITNYLIPTPESDWLFRPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC75</accession>
    <name>A0A8G1RC75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_445455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519961.1">
        <property type="nucleotide sequence ID" value="XM_025659265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC75"/>
    <dbReference type="GeneID" id="37162667"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="185" mass="21092" checksum="FA0584A213153BB9" modified="2022-01-19" version="1">MTEFAEASEDPNIFCLVRTPDQEQFDVWGTEPPVQDFTTGFKNAPDSTLRLYTQNRLDELKTAGKAGGLSPGWLAKLDERSPRDSTVVLQYRKIKANWAQALEDAEEQFHIPGQADVDDQYIWWKWRVPFADSFQLFNSVDDGMPDMIRLFTRPEFVDSKGVLHVDVPRQIIKGEIPDPITESAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCP3</accession>
    <name>A0A8G1RCP3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_362623</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520216.1">
        <property type="nucleotide sequence ID" value="XM_025655634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCP3"/>
    <dbReference type="GeneID" id="37159036"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002991">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF25">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH62294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="760" mass="84546" checksum="1EBB9A9E5AE564BD" modified="2022-01-19" version="1">MVKPSKQYQCQRCSRIFARLEHLQRHDRSHTKEKPYLCTQCPKSFTRKDLLARHERLAHSDAAPGQGTTSSPSVASPQVFDGLNVLASAVTDHPTPATIPGPQALLPGPHEQFTPGLAASVQGHPIATSNPSGQGPSGSAGFNEPFVGYGPATSYDGDDFTTFLDSIPLPSHPFSPTYQPLPLFPTFHFDSASEYSQPVAKTNNEVTTPSSSILPRHGTQLPSLQPEGAHTPYKTRDPSAPISVTAQCRDRIVAKLSSYSNVVPNPYTPSRHALSRCISAYMTNFHCHYPFMHPPTLDVDSLPLHLIFGMASVGAQYCREPETSMSLYKVAKAVTLEHVRRDLQWGCLSPQTEGPMDPVSRGQDIIETVQALLLLISVSCWFERDPPHHEALHIRSSMETLLRQGGLNDLPTQDGSWESWIRYEMVKRTKLIVFCFFSVHTIVFDIPPLILTEELTLDLPCTEREWTATSAAQWLEERSQSRGEPKLQDAMNSLFTHTGAAKTSLESFSSLGGYVLIHAMIQNIWLIQKASRLPVSNGSFLSPSVITSLEQALELWCQCWEHNQESSIDPFNPHGPVSFTSTALLRLAYIRLNADFSSARRLETWDPDEVALSLKNNLSVQRSDRLTRAALHCAHALSTPIKLGINYVARTLVVSWSNQYALCSLECAVLLAKWLEVATISNPEPSLTEQENKLLEFVLEMVMEAQHGVSREWLLANNTRLSATVTRLWARLFTADYIWQLVNLIGSSLNRYADILESDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD37</accession>
    <name>A0A8G1RD37_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_129688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520157.1">
        <property type="nucleotide sequence ID" value="XM_025653978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD37"/>
    <dbReference type="GeneID" id="37157380"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="99" mass="10708" checksum="0F59B4AFB03F6F8F" modified="2022-01-19" version="1">METGGVPGDFLAPVQIFNQCGPKIGGQSPIFVRVAGYGGATGDAPLLWQGIAVDPARPEQPKDAASITHTFRCSNRLARVRRTRQKLLQEEEFLATLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1REP9</accession>
    <name>A0A8G1REP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_455089</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520967.1">
        <property type="nucleotide sequence ID" value="XM_025661366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1REP9"/>
    <dbReference type="GeneID" id="37164768"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF112">
        <property type="entry name" value="L-ORNITHINE-N5-MONOOXYGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH63045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="600" mass="68084" checksum="E7163F35CC5D1EE2" modified="2022-01-19" version="1">MNTRQHRYNFTVFGFKPVVMIMENGLQLQAGAFTLGVLAHSLYFRSGEHHLYPIRYLYTYGGLSILVAATIQYAQKISFTRASTASLSLISTHLLGLYCSLIIYRMFLHPLGRFPGPLGARLSGFWLPAKLLHQPLYLVLEELHKKYGPFVRIGPSDLSIIHPDAVNIIYGFKSSCTKAPFYDLGAPVQSLHAHRNREAHDQRRRVWSLGFSDKSLRAYEKRIQVYRQKLIDLLNSAAGDQAINISNYLTWYSYDVMGDLAFGKTFGMLDASANHWAIQILNDMLKPLEFSVPIWALRLLGSIPGMNKDALRYEKFSHQRLKTRMRKTPEIPDISSSLLVELQGRVPTTKEFYQLLGDVELIIAAGSDTTAAALITIIYELAKHPVHVKMIREELSLCAVEPSGEYMHEKIAGLRHLNGFINEVLRLHPPIGSIIPRKTPPEGIMIGDTYIPGNMTVSCPQWVIGRSNAFYENANRLLPERWYRYPEAMKYKSAYAPFLLGGEALPPHRPGFLHTSLRSCHTLRLSCPYACIGKPLALMNMRATVARITMTFDLQLPSNDDGTLLDKNMREHFSSYVEGVYILFKNLQTNQSSRQRVKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VG91</accession>
    <name>A0A8G1VG91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-methylcitrate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_508309</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825089">
        <property type="protein sequence ID" value="RAH51996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509918.1">
        <property type="nucleotide sequence ID" value="XM_025664453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VG91"/>
    <dbReference type="GeneID" id="37167855"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF15">
        <property type="entry name" value="DEHYDRATASE (PRPD), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="3">
        <location>
            <begin position="21"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="4">
        <location>
            <begin position="295"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH51996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="492" mass="53545" checksum="7B4D6502D98A1F02" modified="2022-01-19" version="1">MTVIPAADDNSRKPYDAVIQAIVDYVYDYKITTDIAWSRAKVALMDALGAALESIHTSPQCAQLVGPAFPIAPATSGLFRLPGTAYQLDILKGAFDLGAMIRYLDHNDAFPGAEWGHPSDNLGAILAVADVRSRVALAEGDPDSIVTMQQVLEALIKAYEIQGCFQIKNAFNKVGLDHTILVKIGATAVSAWLLDLPREQALSAVSHAWMDGHPLRVYRQAPNTGPRKGWAAGDACMRAVHLALLAKAGQPGANTVLTTPRWGFYDVLFKGQEFDLPQPFGTWVIETVLFKVNTAEGHGMTAVEAALEVANTLRARGLDPARDIQSIHAKTQAAGMTIINKGGATLHNAADRDHCLRYMVAVVLLKGAQVETADYQDDSPWATDPRVDALRQKITMAEDPKYTADYHDMAVRSVANSLTVTLTDGTTLPEVLVEYPLGHVRRPETPQEVYAKAERNLGLRLSTEKVQHILKTVASEEFMSLPACHFVNLFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHI2</accession>
    <name>A0A8G1VHI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_381646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511326.1">
        <property type="nucleotide sequence ID" value="XM_025656432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHI2"/>
    <dbReference type="GeneID" id="37159834"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="54" mass="6014" checksum="7A7987F7AA8E24EC" modified="2022-01-19" version="1" fragment="single">AAPGKIEDYSALPPLYIDVGSCQSCKKQNVAYATRFLDYRSQADLHVWRGGSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHI4</accession>
    <name>A0A8G1VHI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_383403</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510592.1">
        <property type="nucleotide sequence ID" value="XM_025656517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHI4"/>
    <dbReference type="GeneID" id="37159919"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="73"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="280"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH52670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="410" mass="43958" checksum="A93982293AE308ED" modified="2022-01-19" version="1">MEGPSGISAESDPPTPPPSERASSPTAPLHGRTSPFHLAIMRIGSHPVLKALAGFVLLGLLSGLLGWPRQLVFWLNLVAFVPLMAIITIAITELSHTLGPFLHEILKSTLGNSVELMVGLVSAQMGQGRIFHSVVVGSILCYSLLVLGSCFLISGYDKEHLHFDRNLTSIMSSLMMMVCISLVLPGVMVTFPSLDTLSISAVVTSHEVQMVSYGIALILLGLFGVFLLFQLKSHAALFRIAEGAAESHLSDASSETRADDIRMPMDHEPVMFTPQSAGVALLIAVACLTGGVVHIVNSVNAALERGTGTSFPILVWVPLVGNVSKYLTIVVISRQGHVEVAVRNILNSVLRLTLLVTPTLVLMGWSLGQSVTLQMDNFEATMLFLAAMVMSHVIHEGRANYFDGLMLCGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHI9</accession>
    <name>A0A8G1VHI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Globin-sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_176099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510607.1">
        <property type="nucleotide sequence ID" value="XM_025654322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHI9"/>
    <dbReference type="GeneID" id="37157724"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071:SF1">
        <property type="entry name" value="GLOBIN-SENSOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071">
        <property type="entry name" value="PROTOGLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin-sensor" evidence="2">
        <location>
            <begin position="25"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="417" mass="46426" checksum="00EA2589FE6CAD9E" modified="2022-01-19" version="1">MGSLSPVQDGIKQVTRKELYTDFSKRMDFLRLFLDFTDDDIIVFNKGAKFLKAALPVLTHRLYAKMLDFDITARALRVRSTESDAQVDEYFTLDGPHVQRRKIFWKWYLTRLFSDPSRLEYWEYLDKVGKMHTGKILMHPLKIEYMHMNTCLGYVKELAYETISGHPEMSYPFKFALIRAFNKIMTIQNDLISRCYIREGQEFDHHSPSPGEAPTTGGAPPHTDAGSNTDSCVSDTRSTADTRSSTDSRSIPDPQSYADIQPNPDARSLPETRPNTGGGSAAETGSIAESRSNADTCSIPDSTANSETSSMANERQLHPRCLVPGLSQSRPTSSKGSVPSLRDRSASFDLSRVRTASDSISSYDPPSTAGSSQRLGPSYAGTATGFTSPFTVDQLGQSFETKIWSAKPKQKWFKASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHN4</accession>
    <name>A0A8G1VHN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_463575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825081">
        <property type="protein sequence ID" value="RAH52820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510742.1">
        <property type="nucleotide sequence ID" value="XM_025661935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHN4"/>
    <dbReference type="GeneID" id="37165337"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="280" mass="31118" checksum="6ED9EC3FD8779106" modified="2022-01-19" version="1">MPSSSELALIRKYPPTPYKGLQALIEAIADLYTNLETGDVSQYLSFKDVSPKDFRFIESHRKKLGSAVRFTYYPEISTLVLKVVTNTTLAVHDNLYYNISGKLANMDIDIDQFVSLGASEFEGPWGSIKEGDGAFKNPAIRSEKRHWPSFVIESAVSDDSMPRLRQDAAWWIANSVGEVKVVLIINVLMKTKCIVLKKYGPKDQKSHNTRSQSKGGPNDHRPVLKSRTTVNYGAGSPHVEGDSVKLKFKDLMGRPKGSSEEDVEIGHAELLELAKSVFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VI35</accession>
    <name>A0A8G1VI35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_406446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511207.1">
        <property type="nucleotide sequence ID" value="XM_025657335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VI35"/>
    <dbReference type="GeneID" id="37160737"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="302"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="647"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="861"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="705"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="871"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH53285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1015" mass="110202" checksum="89E26B5CC45B01A4" modified="2022-01-19" version="1">MFTFTPLLGAQSASSKASQSILELDGGIKILVDVGWDDTFDPLDLQELEKHVPTLSLILLTHATPAHIGAFAHCCKTFPLFTQIPVYATSPVIALGRTLLQDLYASSPLAATFLPKASISEPGASTAAASAAASVAEGDESAEATHAGRILLQPPTAEEIARYFSLIHPLKYSQPHQPLPSPFSPPLNGLTLTAYNAGHTVGGTIWHVQHGMESIVYAVDWNQARESVVAGAAWFGGSGASGTEVIEQLRKPTALVCSTRGGERFALPGGRKKRDDLLLDMIRSTIAKGGTVLIPTDTSARVLELAYALEHAWRDAAGSGQGDDILKGAGLYLAGRKANTTMRLARSMLEWMDENIVREFEAAEGVDAATGQSNTEGQRAGQNQGKAEGKGVGPFTFKHLRILERKKRLEKILSDQKPKVILASDTSLDWGFAKDSLRLVAEGANNLLLLTEPLHKERITEGQESTHRKTLGSMIWQWYEERKDGVALEKASDGEMLEQVHSGGRDLSWTDVRRAPLDAGEQLLYQQYLATKRQLQDTSQARGQENLDNAADALDDRSSSTSEDSETEQQGRVLNFSTSLAHSNRNKLGLSDEDLGVNILLRRKNVYDYDVRGKKGRERMFPYVAPRKKGDEYGEFIRPEEYLRAEEREEADMQQRRTDSQTKLGQKRRWDETAPHGRRLSGSGAKRQALGDAQKRDVSTADELSLAEDGEVDAAVSSEDEVEGQSFEGPAKAIYEKATLTINARLAYVDFTGLHDKRSLEMLIPLIQPRKLILVGGMKQETTALATECQKLLAAKSGMDVSAADSAVIFTPVNGEVVDASVDTNAWMVKLSNNLVRRLKWQHVRSLGVVTLTAQLRGPEQAVLEDSTEENPSKKPKLLEEEKKDEGGSTEVATNAPSEGAKPSADKSEVYPLLDVLPVNMAAGTRSMTRPLHVGDLRLADLRKIMQGAGHTAEFRGEGTLLIDGMVAVRKSATGRIEIEASAQSAASTNLGRGGGSFLAVKQKIYEGLAVVSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIF5</accession>
    <name>A0A8G1VIF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_442308</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511537.1">
        <property type="nucleotide sequence ID" value="XM_025658831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIF5"/>
    <dbReference type="GeneID" id="37162233"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH53615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="426" mass="46712" checksum="C26B4453FC5A4F4E" modified="2022-01-19" version="1">MSDLDRAIAQLRACRLIPEAQVRELCYKARELLIEEGNVVSVDAPVTICGDIHGQFHDLMELFRVGGDVPDTNYLFMGDFVDRGFYSLESFLLLLCLKVRYPDRITLIRGNHESRQITTVYGFYDECIRKYGSANVWRYCCEVFDYLALGALVLGASSELEPTGPSMDTTQSTMPIDDELETEILNSRGEVTMSTYRPRPQHSSDPSSISPPRDISATSNQAPFRSGAAGTSASGDAGGSYGSRTGAVLCVHGGLSPAIDTVDKIRLIDRKQEVPHEGAMCDLLWSDPDEIDGWGLSPRGAGFLFGGDIVKRFNYRNDLSLIARAHQLVMEGYKEMFDGGIVTVWSAPNYCYRCGNVAAILELGEDTSNGGTVARSNGDYGRSNGILGSTNKPAVRSPGRRYRVFEAAAQDTRGMPAKKPVADYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VII3</accession>
    <name>A0A8G1VII3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_105359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512481.1">
        <property type="nucleotide sequence ID" value="XM_025653819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VII3"/>
    <dbReference type="GeneID" id="37157221"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="544" mass="60722" checksum="4F91FF9D500FE18A" modified="2022-01-19" version="1">MAQSVELTHATPTHIPSIAEPLAPYIKSRQDALLIRQALTIYLRSHIEFAENNTEHPECHSQSHLALSVPHEAVVDVKRLPSELTGLRRQYLEALQSNVAARREYQSVVEKLTSVGLERSKPRAENLTVDSSAELQEYLRLLRDRRRHAKLQVFEHYIKELKQRDTPRPADLEDSGIHYQQLAPPPVAEVTRHGSTTGLTVEEQMHSLEKAVIRAKAQLEREKGLLEELQAQQAPVEAQDIPRAVKGVALQRTRNELVRWVEEKLVSAGNNENRLASRDFHSEDMDESVRLLGEKKAHIAQQYAAYADARKRLLDAASRACQPVTLPAAKPSSRPTSLVQGKNASEGTQSLDALGVLTFASDVLQPLARSQRALALQKFYLSGMLAKEKATTLRILSRLRDESHLLPEYPTLARQPRFKHATATLALHQGTSTESAKPDQLVDLAEAWASASNAAGMAEQEYVEYRLEEGIETAQDAQQALEDVYEILNQNLEDTLRDRQGESGEDSMWPSGARLTRSRAKMQQSQQPAKGPWSGLHGQVAVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VII5</accession>
    <name>A0A8G1VII5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_379382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512318.1">
        <property type="nucleotide sequence ID" value="XM_025656338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VII5"/>
    <dbReference type="GeneID" id="37159740"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="138"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="420"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH54396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="510" mass="57176" checksum="073D24103BD1261D" modified="2022-01-19" version="1">MHQHAHGISIDFSTPASPGQISHEEAAHYITVYFDDLHPLTPFLDRADFERRIAGPELPELLANNAPFCALYHTLLALGCQYMDGGSFVPGKGKAWNYFQVALSLFPRILAPPQTLLHVQALAAMAVFTMSFSCIPIGETLMSEAARIVQLLGYNAAYVQTENETLCHRAFWVIYWLEKVTSFFRGRGSMIPDYDIGCPVPACSDTAPGELDWLLTTARLGRLMSRTYECLFSVSAVQMHTAARIAAVDSMSRELEAWIQTLPEPYQPGTPLRFSKGKSPSAQDMALQIRFIYYALVMSMCRLRIHLTSDQTNETNQETKRQLMETARAVIYHTRYIEHEAHVPAWQLGIVPVSALFIIFDFVIHNPFHKETATNISFLDIAAGYFSRWEISNRDSLPASTAAEFSHIARQFVRDVQARLQTTDSRRSSRPEADNSVPTTGEKNYSSGFAVDPSQVTNEDSLILPDIEGFSGTGPDQLFYPEDPLQTLFGTYMPPTTDISNMFNSTLWNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIU5</accession>
    <name>A0A8G1VIU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_454291</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509995.1">
        <property type="nucleotide sequence ID" value="XM_025661251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIU5"/>
    <dbReference type="GeneID" id="37164653"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="709" mass="80232" checksum="F5EC8C0A4BACC35E" modified="2022-01-19" version="1">MSKRPHQGSPPRPASQSPDLVDHTPQGLSPGDSEQQHHASGPSKKPRNFIATVACENCRLKKTRCDESRPKCGLCKSLNLECVYNERKTSKRDHSLSLIMSTLHRLETKLENVPTTISKEIQSLRGQMPRSLDGTETIGSLAHHSRSTSSLGRLERLTSQALTPEAMRLNEVEHDDQHLHPNPTEANGLVSISFSQHGVISWAGAQEILPQRLLEAHEKLGKNYVIDIEMKRPQLPMYICPFPAQAGDNWLNALPLAMVKGLSDAYFTTFNLFTPIIDKNYYYAFTLGAAIESNFGYNIESCVVLNIMALGCIAVHAYQEGDFPLLGTRSGRFEPPDWMGVVYENPPGLRFFNTARQRIGFLMCDNNLQSCQFYLLSFIYYSQILRPMDSWAMIHRAATCCLSMLTNHDVHFDEWEGDMKSRVYWNCLMNETILVQELHVPPSGLSRLEEYVPIPKFITFESVGFPASRSLSLEEIDDSFFQYHFLAQVAHRIILTRIRHSLYFHSDSGTFPHPAVNAELRHQLEQWRINLPAALQFPDHTTSALTTNPSTPIPPSPASQQHLPFTPSHRHALSPAIAVSEAMLRGRYMIANFHIGRPYLYKALHTPGSLTDKDLEQIHSGLLNAMNWPVVGGIFQRMKSCIPIKFAFCSQFFGQILLFYCISHSSDRRLQETLPAGWEQWNQEMMQFLEDCAQASPAVAKDLELLRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJJ2</accession>
    <name>A0A8G1VJJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_403477</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512677.1">
        <property type="nucleotide sequence ID" value="XM_025657229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJJ2"/>
    <dbReference type="GeneID" id="37160631"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF116">
        <property type="entry name" value="TYROSINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034255410" evidence="2">
        <location>
            <begin position="19"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH54755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="406" mass="44594" checksum="D632EBC274706D47" modified="2022-01-19" version="1">MVALKALSLGLLASQAWAVPTASQTALTSPAASDAAVAAAAAKLEQLSSYALDQTLADLPSSSEDKQACTRETLRIRRDWRAFSKPEKKDYINSVLCLQKLPSRTPSHLAPGAKTRYDDFLATHINQTLEIHYTGTFLAWHRYFTFEFEQALRDECHYAGDFPYWDWGYDAIHTMEASEVYDGSETSMSGNGYYIPNQGNISLYLGNYAPIILPPGTGGGCITSGPFKNYTVNMGPAALSLPGGSTAAVSNPLNYNPRCLKRSLTTALLQKYNTYPKITSLILDNDDVWDFEMTMQGVPGSGSIGVHGSGHYSMGGDPGRDVYVSPGDPAFWHHHGMIDRVWWIWQNLDLKSREYAISGTGTFLNEPASKNTTLQTVVDLGYANGVPRRMKDLMSTTKGPFCYAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJY1</accession>
    <name>A0A8G1VJY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_80490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513067.1">
        <property type="nucleotide sequence ID" value="XM_025665681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJY1"/>
    <dbReference type="GeneID" id="37169083"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794">
        <property type="entry name" value="THAP DOMAIN PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794:SF2">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="667" mass="71683" checksum="D5E21614B1B76F2C" modified="2022-01-19" version="1">MPTSNTSSPVKRPGLGRRAVSSHAVVTRSSSSTTTISQGELSHSHSSNPQKLPHRPHRPHLVGGGHRNHHRNPSFGKNLNKLQRHQSSHQIGTTTTTTEGPARVHQRKKSAPATPAASPRGHHVRWDGVLDEPHRSTGSMKKNYSSPALRRNTSGVLGKKALVTDRPHSSSGKKKTVGFELADSDNDDADWEDTTQSPESTRRSSVAQSKESVENPAVLVDPLTFVKRSYPQFPRATSLPESTSKSFGEDHLSDDDQDDDDDNTPQQRSDSEERHEEAGRALDHPDIAARLLSPSHSAKAPPAMSSISATVKPTAVESLSRNASLTNLASGPDGARRPLSSSHNTLAHTPGTQAHATSSSIEGGVSKFIINNKTGPHAFSRTDSDPNTPSSFLPHYHPQTPPSPRGTSSRKPRASPPSRPLGAEPHSRTQQKLWLQRTAALNTSPPDGHGVTATVSPSAIDPAFIAVTHARPGAGPFEPGRALVNGPSRTGGAVHDNEVKHIRKAYEKTALELTVVRRFQSPTGDSFNRLNMILTDLKGGAASSSVGQRASLGKPIKSAPALTLLQEGPGRHSASPEPRQLIGKRDHDMHTSVSQAYLQDPDDLVSESDAAQGHKSQHPSHRILSTSDEPVHGSSAPEDITEDTLRVNEAEMMIRRMWESREVATAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VL28</accession>
    <name>A0A8G1VL28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_491542</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512215.1">
        <property type="nucleotide sequence ID" value="XM_025663722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VL28"/>
    <dbReference type="GeneID" id="37167124"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="149"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH54293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="499" mass="55800" checksum="5DEBE23AF397A6F8" modified="2022-01-19" version="1">MSPSPSPSLSQTPQRRNDPFFFLAHFTDPAVKQDKLAIAETAKSSTRRHLDPAYFRQEEPLLPHDSLSAYMPGFSGGDLFLQPFFTPTGHLSMEFMPESALSSTISHRLGEIMMILVETSNSMGQGQQAQLEMAELNSLFTTSNLSVFISAYFQSLHWHLPIVHFPTFDPAIISNPLLLAIFLAGATYATSQDGPVFASRVLDVAEEYIFRQLANLSSNPHPTSAPYLLPSVEVIQGALIIEMLQFGQGETGTRRRIRIIRHPCVISTVRSLGVLQFKRSMTSDMCNDETWRAMIAEEVCIRIACWAFLADGFLTVCFNNHPALSIFEMDCQFPWSSALFEAENASSFSEIAASSTAGRPLPSLREFITRLLDENATADLIQWSRSLVGEHLLILIYAMHSLAFQARTGLFGWISTNSIKRAAENWRSIWDSVSSIVGKEGVHHLGYPKHAEELWWLLTATLDRASGRNVNFRYLDNAATDDLESLNNFIRNIKGPNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLD0</accession>
    <name>A0A8G1VLD0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_421171</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515393.1">
        <property type="nucleotide sequence ID" value="XM_025657921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLD0"/>
    <dbReference type="GeneID" id="37161323"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="705"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="748"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH57471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="803" mass="88717" checksum="1EDAFB3E2CC20740" modified="2022-01-19" version="1">MNSRDHADMPPAPSYPSPNAAQMSQGAMQYYNRQLTADELLSAELSRETSGPGLADGSSNGVHHGQSMVLGSSNPGGADMGRPSSPDQHQQQHMLQFTPSQQVGVDPNHDLSYGDQSARRKRSKISRACDECRRKKVRCDASSESGVETCSNCRRLGVVCQFSRVPMKRGPSKGYIKELAERLHTLESQMQPTMVHPDMPYQTMNEVSSPRAYQDFSPPIDAGPIGRKRTYSVFEGLPSSSFAQAPFNPRSQNAFEAGESATDPCNPSVVNHTAPKSGNLFWSTGNETDLPAGLDIPEVPKQALDEDMTPLDVDEGALNAYYQKIHPVLPILPHSKERLLELLHQCSREVQEIFLYSLLTVTRTNMDRMTNAFERVTSFDNAQDLLLYYTRQPAMLRPAAINLVWLQTLLLMIVDCDSRGPDNFVMKDGVPKHTLIQSATKLGSDMAKAFGQLRTKRSSDPDVDSDANLVRRSWVSLALLSRWYAISVADYSVLGTFEIGGREDERVLGSATAGIASYSTILIDMVTLVAQEHNVCQTNTGLGRLVGANMVAGLERLAEVADFRKPHENPEDGTSYGFFESLQNQLYWTSRLLIKRHIFVHSPYEIIYAAEEVMNELHKASMQSRLATPFDLHSLALASMTLLEATVLPEYSNQCWEALKKLEEILDYRSKRSAESGEYGDIFGTPGWDSKIRVFLEWRRTKAQETQLHDPSLGKSGSAAPPVMGPNEQRSLQHLADLAVGAEGQVAANASSPPPAISEHNLNATSPNMASAAQPHGHVVVDFTLLTKEGYLNVFSGLIYRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLD1</accession>
    <name>A0A8G1VLD1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_375604</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514209.1">
        <property type="nucleotide sequence ID" value="XM_025656180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLD1"/>
    <dbReference type="GeneID" id="37159582"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000002">
        <property type="entry name" value="Dihydroxyacetone kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF14">
        <property type="entry name" value="DIHYDROXYACETONE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="14">
        <location>
            <begin position="31"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="13">
        <location>
            <begin position="405"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="77"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH56287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="610" mass="65478" checksum="6CCE7FAF57C0E5D8" modified="2022-01-19" version="1">MKSDLLHKFHWIRHCPIHTLTRPSAKHFFSDPTHLVQTALNSLTLTNPSLAYDPENKIIFRRPDTTKSKVAIVSGGGSGHEPAFAGYVGKGFLDASAAGTIFASPSAEQIRKAVMDCVDNEKGVLIIPMNYTGDVLNFGMATEKARAAGIKTEFFAINDDVGVGKKKGGKVGRRGISGGILVLKIVSALAEAGGSLEDVYRTAQLANKNLVSVGSSLEHVHVPGRAPPTETIPDGEVEVGMGIHNEPGSHREKFELTELVATMLLQLLDHNDPDRAWITRKPDDEFVLLINNLGGVSALELSGITDEVYRQLNRDYNVRPIRVIQGTFLTSLNGLGFSISLMKLVDTGLGEGKSFLELLDAPAEAVGWSAPIRPETWEHRSDAPVELKRTKLPEDQPSNVKLDVDSLKKVLGSALKRVIAAEPEVTRFDTIVGDGDCGVGLKRGAEAVLKLIEDPSSPLTDDVVNAVNRIVSIVENVMDGTSGAIYAIFLNALAHGLREQDRGTTTPATVDVWAAALSYSLTALSRYTPAQPGDRTLLDALVPFCTQLQKAKDVHVAAKAAQEGTDSTKNMKASLGRSVYVGGEEEWVGKIPDPGAYGLSVFLNGLSEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VM61</accession>
    <name>A0A8G1VM61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_35466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515124.1">
        <property type="nucleotide sequence ID" value="XM_025655489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VM61"/>
    <dbReference type="GeneID" id="37158891"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="118" mass="13190" checksum="8E2F374E6B3FFA83" modified="2022-01-19" version="1">MPAVPNHLDGQLGSSNYPPCMTYPQLSNVFLWRRGDWEFVGKKAGEVAGLGPRQCCDVVIRRPDKKSSGEELPRPQQHPVLGLGTVSILMRDICHHRCQVMTINWLHGLVIPHGFDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMC1</accession>
    <name>A0A8G1VMC1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_459457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515304.1">
        <property type="nucleotide sequence ID" value="XM_025661658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMC1"/>
    <dbReference type="GeneID" id="37165060"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH57382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="297" mass="32199" checksum="2EAA2F084E5EA24F" modified="2022-01-19" version="1">MFTSTKPTFTPSTDIPSLKDKVILVTGGTSGLGKQSIIELAKHGPKEIWLAARDPKKAASAVTSIKSGLPEPVNIKTLDMDLTSLDSVKQAAERFLSELSRLDILLLNAGIMSVPPGLTNEGYEIQFGTNHLGHALLAKLLTPLLLETTALPGGLDVRVVVLTSYAHNYAPEFGIQFDTLKSRAEGMNTMARQYPQLTVPLVHPGLVRTNLATTMGQGSFIMRMLWWIASLVTGVDVETGALNQLWAATSPQVESGQYYVPVGKAKDGSKYAQDLGLGKELWEWTERELEAYMDASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VME6</accession>
    <name>A0A8G1VME6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SNARE complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_448606</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516518.1">
        <property type="nucleotide sequence ID" value="XM_025659978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VME6"/>
    <dbReference type="GeneID" id="37163380"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15859">
        <property type="entry name" value="SNARE_SYN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000060">
        <property type="entry name" value="SNARE complex subunit (Syn8)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF423">
        <property type="entry name" value="SYNTAXIN-8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="170"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="105"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="42"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH58596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="260" mass="29566" checksum="D4000553165EC866" modified="2022-01-19" version="1">MPNPSQLLLLADHIKLSLLERQRAISLDLEPNSQDGEISRSLDSLKEGIDAVESDCARLEEANDESATEMRDQLDHLYSQYRDLTSQFRGSDGAAADDPVEFTNIKKSSPDLKQPVPQHPSSKSVRFMDNAAEEDDLNRRNLFQPYRDSPSPQGVDTSDMSNQQVYDHHEQIMRDQDEQLDRLGESIGRQHQLSIQIGDELEGHVALLDDMDGHVERHQGRLDKAKRRLDKFRRSASENWSMMTIIGLIIVLVILIVLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNC3</accession>
    <name>A0A8G1VNC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_487159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516354.1">
        <property type="nucleotide sequence ID" value="XM_025663435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNC3"/>
    <dbReference type="GeneID" id="37166837"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="245" mass="28050" checksum="0CAEDDCDE4850AF3" modified="2022-01-19" version="1">MTMKSSLLKKRKLLMQANPPEQEKENSEKSSAKKLGKVERFQLPSSPEEWQDLVENAKLEALTIKTLPTEMFGSASQASDKQYLMLRCYSPKIVHPTEFSNHMSKFGFCKNMLRDATSLLDQSRDWAGYIRTLQEHISIRELRESHAHLWPGSFMAAKRLQEQTATVQGTNDLYSHANNQKSEKCRDAEDEATPNAALIVLLQEITHIVERTDFEWVLNRAGFLADFGEWATISRLHRGSAAFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNN9</accession>
    <name>A0A8G1VNN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_366129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518016.1">
        <property type="nucleotide sequence ID" value="XM_025655767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNN9"/>
    <dbReference type="GeneID" id="37159169"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF12">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G14540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH60094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="280" mass="29453" checksum="86C003C168882437" modified="2022-01-19" version="1">MSASDQVQLDNFPTIFSLEGKVALVTGGSRGLGLHTASGLLQSGCSKVYITSRKASACAEAVAALNALPNKPPHATAIAVPADNSNMEELDRLVAEVSKTTSHLDILFANAGATWGEKFDTYPEDKFSKVMDLNVKSVFYTIQKFTPLLTARATQDDPSRVIVTGSTAGITPGSLGPSATFSYSASKAAVLHLVRNLAVDLGPRHILCNAIAPGFFPSKMANGLIKIKGGLEDLERRSPNGRLGRKEDIAGLVVFLASRAASHMNGAVIPIDGGNHLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPF9</accession>
    <name>A0A8G1VPF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catabolic 3-dehydroquinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_476412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517717.1">
        <property type="nucleotide sequence ID" value="XM_025662781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPF9"/>
    <dbReference type="GeneID" id="37166183"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="231" mass="26878" checksum="9F6775BE7B5975B1" modified="2022-01-19" version="1">MVVNITAEDPQPTIHSHINGTTEEILDRLCVTELLKGWPVYRDASEWAHYRNCFAEQAYIFTTWSGGMPIDEFIEVSKKGRRNGDHIMHRENGTLVELNSKTGRAVGKMKATITQRFSFDGIEFDVECDCRFIMWCQKDPAGWKVHYKRLFYEKDKIMPVDGKHVPDFSEEELKPYPYGYRYLGASQARLGHKIKLDLPTMEDNDKFRGMYEAMEKWLRGEDIKETLGIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPZ5</accession>
    <name>A0A8G1VPZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_435740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519396.1">
        <property type="nucleotide sequence ID" value="XM_025658541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPZ5"/>
    <dbReference type="GeneID" id="37161943"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH61474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="223" mass="24863" checksum="B851A1BCD0CA8027" modified="2022-01-19" version="1">MTLSCPNWLRVFLLVLEIAVFLPQLLRIWVQKTSTGLSLIYIFLNLLSATERFTVGFSAVVNLTIAGADAPAFFVHDPRTVGDWLNLLQLASFYVSPIPLLAPPTPVSLISIVPLFTDALFPSIFHEPGERELDLGVAIFMGFHLFYLNTIFTLLSICSIIPQAVQFRSLSLNLGVVRVRDCALQGVVLAMLTVSWVFRVKLPDGVDVLTPFRSIIWEKESGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ04</accession>
    <name>A0A8G1VQ04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Squalene monooxygenase</fullName>
            <ecNumber evidence="16">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_388249</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Endoplasmic reticulum membrane</location>
            <topology evidence="3 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="16"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519426.1">
        <property type="nucleotide sequence ID" value="XM_025656706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ04"/>
    <dbReference type="GeneID" id="37160108"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000166">
        <property type="entry name" value="Squalene monooxygenase Erg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 16" id="KW-0274">FAD</keyword>
    <keyword evidence="5 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="17">
        <location>
            <begin position="181"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH61504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="479" mass="52355" checksum="E69CE2B8F4AC7A77" modified="2022-01-19" version="1">MAAAVVANGHTTPSADVAKQRRLIHHHADVVIVGAGILGCALAVALGRQGRSVLLLEASMKEPDRIVGELLQPGGVEALGKLGLADCLEDIDAIPAKGYYVSYFGKPVSFAYPKPSPSSPAPQGRCFHHGRFVMKLRAAALACPNVTVVETKATDLVTCSHTKQVLGVECVTGDMKDCYFGHLTVVADGYASKFRKQYHSNTPKVRSRFWGLELIDADLPMPYHGHVLLSDNAPILVYQIGTHETRILIDIPENLPSASVKNGGVKNHLRNVVLPSLPESIRPSFVAALDKGQLRSMPNSYLPSAPNKTPGLVILGDALNMRHPLTGGGMTVAFNDVVVLRDLLSPEKVPTLANHEQVLRQLSSFHWQRKKASSVINILAQALYALFAANDENLRALQRGCFRYFELGMTSGPIGLLGGLIKKPDVLFWHFFSVAFLSLWLVITEHPFYMLPLAFLKCIMVFWTACVVIFPYMLIEAFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ52</accession>
    <name>A0A8G1VQ52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_412251</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519591.1">
        <property type="nucleotide sequence ID" value="XM_025657558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ52"/>
    <dbReference type="GeneID" id="37160960"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="34"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH61669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="373" mass="41061" checksum="7B39783E3343DCB7" modified="2022-01-19" version="1">MASSEDGNASDNKGPMILSVLWALTGLTSVLVIARMYIRTSLLHNLGPDDWLITASLVMGVVYCAITTINVDMGYGKHAWLLSERTVERATFLNCLSFLSGIISFAIPKLAVTAMLNRILNPSMTQRICLWTLTGFAAVVSGICIIVLFTMCDPPEALWKTHLVTEGKATCKDVWILIDYAIFTGALSAFVDLMLAVYPSTVLMKLHMSLRKRLALCAALGLGSVASAMAIVKCTQLKGLADKTDYTYGTAELVMWTNIESNVVIIASCTPTLQPVLELILGKRTTSSYNNSRNRYKGSSQLPDSSYDHSKLSKPRKPDYEVTTAGSQESILREETNGRIESHPMGAIRRTDNVTVEYESRSREDPEEPRVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQJ0</accession>
    <name>A0A8G1VQJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_506446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518842.1">
        <property type="nucleotide sequence ID" value="XM_025664371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQJ0"/>
    <dbReference type="GeneID" id="37167773"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="342" mass="37858" checksum="2B1F524017730BE5" modified="2022-01-19" version="1">MLLASIVPSRATTTSRRAVGQQSRTSAGILESTYNSLNRGYRGIHLWNKKSEVVKHRLDTVLDGLDFARDSQLATRSNTSSQELATIRDGTAQIGVSQANLRADLRRPEFMNRNWIPHWSYQKSSIAAACIFTAVTVMALTFLAILSIKKAKRSWERHKREKKDYANSGYSALSLIEEGHKMTATSSKQISRETLMFSRSRSPSPTYLIEQDGPSVTRVYHTSRSVSTITLDSPSSTLGDAGTTTELNAIPGRPASALKRSRHERHGSKARSIVVVPSPLRAFSVKPMIHHTDPAYGLERTFLNVEHEDGNVPSNSKRDSAGGNSLFKLPAIQRTMSPLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQK9</accession>
    <name>A0A8G1VQK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RGS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_483953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519863.1">
        <property type="nucleotide sequence ID" value="XM_025663200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQK9"/>
    <dbReference type="GeneID" id="37166602"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="187"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH61941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="372" mass="41772" checksum="B1CAD5D6A344A5DE" modified="2022-01-19" version="1">MASPSLSSLEQRNRLPTLFEVLSRRTLAPVDLFSFYIYMRDQQRSVDYLDFWLDVSQHMSLCRHYVRELRRSVLVATPDLEKADSKGSSGALDNFEHYNDIPLVEAGPSNSRHGLNDVGDRDADQRLSAFLRSEGQTSGHSPQSSLGSQNAARTTSNELQPRDSSGTRNDSPSPGHTVARADIRASAEKILYTYLLPGAEREIVLPEEMVSGIINLIEDDGRDDPEVFDPAKDYVFQAMERDAFPGFLQAKALGNLVPLTILARLAFALISFGGGFWGAFYVVLRDKPRHIRCWLILPFAIASYFIVSYQYKIDPVMAFLGYSEYTFMNWSPIREPYVRKLLNKRATATAMIAFFVAAALSILFIFVPGTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQR0</accession>
    <name>A0A8G1VQR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_484324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520236.1">
        <property type="nucleotide sequence ID" value="XM_025663231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQR0"/>
    <dbReference type="GeneID" id="37166633"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="651"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="758"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1212" mass="132280" checksum="BE4024C7C44D8C04" modified="2022-01-19" version="1">MWIPLREQLTGGGAAGAHGLYTSEMLGNILPKGKAFARLPGKRPSTDVRGASSESDGDSLPGYARQQHMWSPVILRSVSLAVFVVLFICFIIVIEVLYSVSTRKEGLSTSEERYHYLWTYGPTAVLTIVAGFWGQVEYRTKQLMPWKLMNQGPKPATRSLLLDYVSDWNVVILFRAMKQSSWAVVLAVLVTLLIKLITVVSTGLFMLQNVYMKDVPTTLTTQASFDGAGYNGARVDGTAAMVVAGAWWLNLSYPLGSTDKYAFQPFTTSGKKLGADAVISGTVDMFSADLQCDVATVANWTSGCSTQMCEYDELNMTLSTSSCSKYPFTSFEKSSSSVGGYYADVFSATCTDTDSADSLNQKRLIFAAAHWSENSTQIQALVCSPIYTILQGSVSLLYGNQSVTSIQPYNNDTSNRTVPGFEGMELGTGLISSLSLAENTLDTLNYVDTSTHALTTYQYNLSDPNSTYPSAFYLVANLTSPHTMKDLLDASILEKVSRPTFSAMAAQIARQYLLSSADENFAGTYSAHIQRVVVRELSVRIMEATLAVLIILTAALWLWRPVRCTSRDPGTIAGLASIISRSPKVSERLTGCKNAQDLTTNLSDGRFYTRVTDNDGWRTFGIEEDQKATEATRPGASSGPLTWWRPISVNVWWWIISIVLPLLIIAGLEASYQVSARQDGLGTVTSGGYIHYVWAYLPALIFLIVRIFFDCIHFSAMVFQPYLELRQGGVTAPGSLMENHLSKLTLFSFFTAIKRKQWAVCATGFTVLLAPALTVAVSGLYSTQDIVYTRPASIARTDTFNTTISPLSSTTTDPGLGLTGALVVGANLSYPAWTYDELVLPTLSEASLTDKEGVVRTNSSSFNSTSDSPILLNVTLPALRANLTCDALPRDIVYTIRPASDFSSMFTLRMQLDKKCQGVDTSTDFAIETDYPNATRTTFGAFKYLKDAIDFGDCPVLMGFYGVIDGNSTAQIRGFTCNPQIDETDATTSFSLPGLEIQSAAADDSTSRVFSTNISTTLKFESFLSQPVNKEDQAFDAFFSAMLNDQKSLFLSDITDPSYYSTVINATQHLYRTLMAQSMNGNARIPSSDNQTTFPGTIVDPNRTRLTQSAISTRILEAFLAAMVVSTLVASYFMHTKEVLPFNPCSIAGAGALIAGSDVLKSDTLPAGSEWCNDGELLRRGYFSGLVFGLGWWAGDDPRFGIDVGRATEERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR43</accession>
    <name>A0A8G1VR43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH-dependent FMN reductase Lot6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_502481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520433.1">
        <property type="nucleotide sequence ID" value="XM_025664195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR43"/>
    <dbReference type="GeneID" id="37167597"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF26">
        <property type="entry name" value="FMN REDUCTASE LOT6, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034741609" evidence="1">
        <location>
            <begin position="21"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="454" mass="50763" checksum="2DE83E7C1ACE425D" modified="2022-01-19" version="1">MVHLSILLCSLVALLPAAAPLETITCDICILGGGSSGTYSAIQLKDAGKHVVVIEPNNRLGGHAETLYLPDGNYVDYGVEGVFNNELSRNYFRRLGVDWKPLLPLNKRTDFVDFSTGERVDPPAGTLQALVSTFLYRSSIKHWTFLTRGVYDLPDPVPEDLLRPFREFVEEHSLEAALHVVFLFSQNVGNLLDMPTLYAIQNFGVPHVDALVHGYITPKNGMYELYRQATEILGSDVLFQTNVVATNRSDSGVEVTVQHANGTRKLIKARNLLITFPPLMQKLQGFDLDKAETDLFRKWFWRTYYVAVVNNTGIPDKLWVTNTDPTNGLGALPRMPFDFLLQYMGAPGHSTSKLVGDVNFTAEDARDLIAADFARMKAKGTFPIEDPQIVVFGDSSPETLMVSPEEIRNGFYRKLYALQGRRSTYYTGLTFCSDFSSLIWAYTETVLESMKCDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRD3</accession>
    <name>A0A8G1VRD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NACHT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_445153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519669.1">
        <property type="nucleotide sequence ID" value="XM_025659188.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37162590"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF9">
        <property type="entry name" value="NACHT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G01760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="299"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH61747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2058" mass="233673" checksum="509B208E0F4B3A07" modified="2022-01-19" version="1">MAPSILSPVPSSFASPLSPKMPRRISGFAESDTMSNNGMSRSITSRRVSSRRLDPQETEFSRKLSILQRQTGDELGLTISGDSYEMILSWIQDERMTLVPPDGSDYDKVLGWAQLFVTRLRSFEEAIEGFTNVSGLAFQMAYGYCLLLLKLGDENASALMTSFGFFYSNSTALGNLLERTGLFSVSSDIRRQLVQALEDLVHLVASVAMHFHKAVLRLGDEWEYINIYEAFPEQIHKFRRACEEISESMWKHQLVKERGDETKVADVRAVRSWLNPEDRVLSNVAETVSHLAHDREENTCRWVKQALFDFVTSEDKVLSIVGKPGSGKTVLASVLVDNLQHPIRGVPYKTLFVPINARLPAGTRPRAIVKAILSQLFEKRIGNVELLQILTDAFQRSKKATNDNDYDNILWNALENALGAALQGAKDLVIVVDGIDEASCGESALLQKLSAATMKGTNVKLIALGAETPAKAPGHHTVPVTDERIFEDIATVVRSQFLKARESLVFPELDDIEQESIVDRITEASKGSFLWAKLASKRVRSADNADNLNKAVDDVVNAKMTITNLVLETVQHKGVTDEARLMLLWLATADRPLLFKELQTLASIQIDKLAIAEGYQIEPRKVLRPVSSLVFFQDGQVYLRHGLIREAVLEVFSKGKLIPNVKDRHADFVTRLLIYIKSYVTEPQGKEPSLSPLIGHETDSLVSRYPLLEFAVQYWVSHLRQTTVFVNQGETGAAKEFAKVLPTSITVLLLQRTLWANRPTPELLTYQTTVTTICRQILNPKDRVTLQSIINLALFFRDVEYIPEATPLLFEATRLSRELLVNSPSFTAQLANIFLELTVSRVTESKTEIMTMREETLNLLVTCYTKLYGESHKMVISTREQLVKHYQTIKDFHKAEEISKHIKILTVGEQGIESREYHGDWGVRVRGHRGKVFQIRVNDFLEIEEHDLLIERSESFDFEAMIKEAEQYTAQGKFDLAERIYVEIWQRVNKECRTNMTALWEERKLASVLAYSHFLKSQKKEYQAASILSSAWQEHEQTSLTISDTSVSYFQEIAKMMKVVGISTLALTVFKHCSEYYKSTNRTQTSSFKEVQQSIESTSKEVMQSFSSETVMSETTIEEMVYEASSSITTMSQMSFTATTELYAQYVEQHRWQAATRLIKKVLHGVWPALFAPNLQDVTLPSKHVESCIDLAERLSKCYYSRRRLSKEEDIRVRIYRALRGGRKVDDKLRQHNTDELLRLLKRNSQTDKIINLHQELLNDYVGHYGPGDAIVIKTLWTLAELTHPRPIFVDYYLQIVRTLNKDSTTCHPEAFQPLVVVATELWNQGRYSDAVQHFKILFTSFISNPKLSPRFQDQTFVQTIFNRYTHCLRSVRTEFTALHQVTVEYQTKVKAVFGVTATISLQASLTLAKLCQESKSYEVQAISIYEELLATKSQDIDLGEISNTLDAIYEEQAALVTENAESVTTQQAERALKVLKKRTSTVRKTHGWAHEESLTRMKQMISFHAERKETETVLSELKQATVEILKSETSTTRLIAAASTIASSYIASNQIQKATELTQEIYRQIVMKDTSNVKSVQFDLASKERQSLSFLAQLEYSLRRSTSVTITEILAALTTEYVYFEEFRSLTKSKTSSIHTVSVSTARLYHFLLSNNRQTAAARVFDEFVDYFVATEGKRVKLTEPAQVRIFAETILRHFSTHRSDDFIRSIGITSNDYVDQLLKSQRWGSACDLALASFHYIKSHQEVYRSVGIVKFIFALGMTIAGRDLVARPDEASRQKMLGVSSIIIKEALTVIKGLKLDMGGVNFEQLSKLIGLLGDLKDYGNLAWLLTILWDSREAHRNWPSYTLSLGHRLIIARFQIGKYKDAIRLAEDITYNCRRVHGPRHPSTLEMSTLLTQLYTKVATSHQNHKELANRYYKKCAQVHESILRAFSDPYYADYEENLDASLDGSMYGDGQDSTPDTVPEAQRVRQHLQLFKLAVERLGDWPGDYQDYVRMNRDVFAAYLEDLKGVEGVEKWNLKAFGSGKASSNDDVLNLDLQSWDIIDTQGSPVVEPEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRM0</accession>
    <name>A0A8G1VRM0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydantoinase/oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_410953</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521136.1">
        <property type="nucleotide sequence ID" value="XM_025657501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRM0"/>
    <dbReference type="GeneID" id="37160903"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.390.10">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="entry name" value="CV3147-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048350">
        <property type="entry name" value="S-Me-THD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024071">
        <property type="entry name" value="S-Me-THD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010318">
        <property type="entry name" value="S-Me-THD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="S-Me-THD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF10">
        <property type="entry name" value="HYDANTOINASE_OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20906">
        <property type="entry name" value="S-Me-THD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06032">
        <property type="entry name" value="S-Me-THD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160991">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="1">
        <location>
            <begin position="213"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD N-terminal" evidence="3">
        <location>
            <begin position="615"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD-like C-terminal" evidence="4">
        <location>
            <begin position="778"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH63214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1001" mass="106261" checksum="D91BF4CB7D807F15" modified="2022-01-19" version="1">MAFYRIGVDVGGTNTDAAILNTAAATLHEQDLHRDRQRGVCASSKTPTTADVTSGICTAIVDVLAKAQIPAHEVRSVAIGTTHFVNAVVEADPGRLNKVAVVRLCGPYTRAVPPFPDFPPRLREIIGGPVFYLDGGLEIDGREIAPICPQQIEDAVSAIEKAGITTVALVGVFSPLDHGGANEAACKKLMLQQSPDLSVVCSADIGSVGLLERENATILNASILALAKRTIRAFCLAMKNLQLKCPLYLTQNDGTLTSAAMAAERPIQTFASGPTNSLTGAAYLAGLDQRSITSRTATQVLVMDVGGTTTDVCALLPSGFPRKAPNFVEVGGVRTAFSIPEVLSVGLGGGSRIHIDGAEGTVSVGPDSVGYHLTQDALVFGGNTMTSTDIVVASGKAELGERSRVKHLPITVLTEARAGIKKILERTIDAMKVSDQPVTLLLVGGGSIVYMDALEGVAECIVPPHHDSANAVGAAIAKVSGEVDVIEILEGRDEGAVVEAAKQQAIQAAIERGADKDDVSVVEVDKIPLQYVTNKAVRLVVKAVGKLATPAPGDSAEEHLVSWMSTDVDDSSFKEASEVETVVPALISTKHSASLDLDTYVPEVTDQVWYLSAVDLEFIATGTGVLGTGGGGPSYLQYLQCLDWLQSPDAKGRMRVVSPDSMNDSGVCVFGSWYGAPSVSGERIPAKIELTTAIDHVVRLSGHTHFEGIIADEIGGGNGMSTFPTSAYYDIPVLDGDLMGRAYPTMEHGTPYVYGHPIIPCVVADAKGNVGVVLKAESNRRVEELLRCQCVNLGISTAVAAVPLTFDIVKKYCIPNTVSQAWYLGRAIHRARRSKTDIIKAIFETTLGKLLYSGKIIDVKRDVSRGYTVGQCTIAPLSGEERENMDNQVSAETRHLVIPFQNEFLYAAYIDPAYPTAQQVICTVPDLISVLGQDGEAIGSQELRYGLRVNVIGMAAHPLWTGDERGLRVGGPRGFGLNMEWTSLGPYQAPRSVIAEFNQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRS9</accession>
    <name>A0A8G1VRS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CWF21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_444678</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521316.1">
        <property type="nucleotide sequence ID" value="XM_025659080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRS9"/>
    <dbReference type="GeneID" id="37162482"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="65"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH63394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="216" mass="24823" checksum="C872C91CEC22DB76" modified="2022-01-19" version="1">MSSNVGLSTPRGSGTSGYVQRNFAFMKPRNAGYGAPYPPISGANSSSDHPLDKPFKQRQPDKQILEHDRRRAIEVKVMEERERLEEENERIEEERSKKKKGSKNKKDDEVKKEEGEEDEDDEGGEEKVLTEEEIDERCEALRKRLVREMEEEEKERERGNGGGGGGGGAGRRGRRAWDLPPKERRQFKSYQVHELAEAKIEESERLRRALGIKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRU4</accession>
    <name>A0A8G1VRU4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_445644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520134.1">
        <property type="nucleotide sequence ID" value="XM_025659310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRU4"/>
    <dbReference type="GeneID" id="37162712"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013893">
        <property type="entry name" value="RNase_P_Rpp40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08584">
        <property type="entry name" value="Ribonuc_P_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH62212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="383" mass="42809" checksum="4745934236C307DA" modified="2022-01-19" version="1">MLDFEDDASKREKCYTTIGQLPAFIDPKQPPTKRSPFSAILGHPFVHTVEVILPKDILSYVEPQLQNLRYARVFMSLSSLLEGEFFNTYIKTGNILMISEGRSGSDSVFTLKDGILKLELSKEIFERTGLTGKPVRSGGRKHAKERFIVEINLRLPSMLHGKKGFERIVWAFKNVLNQSVAWLFFDLTTSSGGVSEDDPSLKGNHPQIINYKPIITEHSNILVPRLPGPEITDKSREAAELEDHCSELSEWLAMVSLQSPRVSVYDDVDPYLCRYSVPDSDNAKPTSLFSLKWHGLVPSRWIIELLVAILKETAPKSIAPYAWFALSASALGREAVEARDGYTVMVLPTHVPKQDVSGVQADSSSKGDGRHFICWEYVGASIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRU9</accession>
    <name>A0A8G1VRU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_445657</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520149.1">
        <property type="nucleotide sequence ID" value="XM_025659317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRU9"/>
    <dbReference type="GeneID" id="37162719"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000103">
        <property type="entry name" value="Mitochondrial glycine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="125"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="221"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH62227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="315" mass="33713" checksum="2B56DB6A59BAF835" modified="2022-01-19" version="1">MSNNAVYAVPQVKTTSTASKTTFHFTAGLFSGLTSSILLQPADLLKTRVQQSQNASLLPTLQAILSSPNPIRNLWRGTLPSALRTGFGSALYFTSLNALRTGLAQSNGIAPVTNSSSALPKLSNTANLATGAAARVAAGFVMMPVTVLKVRYESDYYAYRSLFSAGRDIVRTEGFRGLFSGFGATAARDAPYAGLYVLFYEQLKRRLAGLSGSSSDQQPLKSSSINFVSGGLAAGLATTITNPFDAVKTRLQLMPGRYGNMMRAVRLMVQEDGVRSLFGGLGLRITRKALSSALAWTVYEELILRAEVQWGSKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VS80</accession>
    <name>A0A8G1VS80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_447090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518455.1">
        <property type="nucleotide sequence ID" value="XM_025659645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VS80"/>
    <dbReference type="GeneID" id="37163047"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH60533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="133" mass="14975" checksum="B4EF433A79FC70CE" modified="2022-01-19" version="1">MDHELWTPRFSPLVPGPGLRRYCDVRVSLPAPVNVPPHLCFFFHLIFFPCSAVLCRSLAGPRKAYLLVRSVDPSLKCISSIREVVRLNPRKSVTQRETPSLDLAASSRLHIPYCLCPPSSWHESNGGFRLLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VTJ7</accession>
    <name>A0A8G1VTJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_388980</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519805.1">
        <property type="nucleotide sequence ID" value="XM_025656731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VTJ7"/>
    <dbReference type="GeneID" id="37160133"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF1">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="55"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="160"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="269"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="297"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH61883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="414" mass="45533" checksum="6B683168B8B6BD8F" modified="2022-01-19" version="1">MFSEGHGPSGAASGSQEQQGTTSDSPPSSTLHVSAESPSQPTFLDRFEMLATRVPDYYITPFCGASAGVASGIVTCPLDVIKTKLQAQGGFARRRGGKSVEAKTLYRGMLGTGRVIWREDGIRGLYQGLGPMLLGYLPTWAVYLAVYDRSREYFYETTDSWWLSRGYASITAGACSTLATNPIWVIKTRLMSQSLRSSSEGYRAPWQYKNTWDAARKMYRSEGIRSFYSGLTPALLGLAHVAIQFPLYEYLKMAFTGYSIGEHPDTGSSHWVGITSATFLSKVCASTATYPHEVLRTRLQTQQRTSPAASPEEISFRGGMDHPQGHSRPPGAASSDGMPNRPRYTGIIRTCQTILREEGWRAFYSGIGTNLFRAVPAAMTTMLTYEYLKKTIGHVQHEGELKLQKLEATSDSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VV24</accession>
    <name>A0A8G1VV24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_444711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521350.1">
        <property type="nucleotide sequence ID" value="XM_025659091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VV24"/>
    <dbReference type="GeneID" id="37162493"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF270">
        <property type="entry name" value="O-ACYLTRANSFERASE AUSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trichothecene 3-O-acetyltransferase-like N-terminal" evidence="3">
        <location>
            <begin position="17"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH63428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="467" mass="51597" checksum="35A17C16E3972DAF" modified="2022-01-19" version="1">MAHTQDILGQLPLLQSYTHAILCFQLASNTTPTIDLESAVQRLLTLFPILAGQVIKTGASPTSSGAYQVVPYPVRKFPIIRYVDHRSDPQIPSYNTLRTAHFPFNQMPSTHFSPPHPVFPIPYPDTEPAPVLDIQANILNGGFLLTLAAQHNIIDASGIFQIASLLARLTRGESIPKAEVTEGNLDRRDLIPLLDDSQPLRYDYCEYLPSFMPKIPPNLTALFPTFQWAYFHLSRRAVEAIYAEAAVASPSHSTPVQITPNDALTAFIWQRLTLTRLHHSPSPLAATDVSKISRAMDLRRTLHLSPAYMGHMIRTATLRLPLGEITSLPLATLAAKLRDQVADLRTLDAVRDYATFLARQPDKSKIAYSGGGFQLATDLSCSSIAHVDYDRLNLGGAIGRCEGVRRPGGGVLPGGCYIGPAGDWYGSVGDEESRQETGIEVLMCLDGWEMEGLREDERWREWVEYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQD2</accession>
    <name>A0A8G1QQD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_241889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825097">
        <property type="protein sequence ID" value="RAH51669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509591.1">
        <property type="nucleotide sequence ID" value="XM_025654852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQD2"/>
    <dbReference type="GeneID" id="37158254"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH51669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="85" mass="9565" checksum="729A370D9184B239" modified="2022-01-19" version="1">MQKTLNYDLPHSPITTPPSVRHHLACGSFVGLRIETVRFWSGIYLSFFSFALGRLVGLVPVHGICVCFGWDSGPKKKKRKKKTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QQG1</accession>
    <name>A0A8G1QQG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">DNA repair protein rad5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_524920</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825095">
        <property type="protein sequence ID" value="RAH51707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509629.1">
        <property type="nucleotide sequence ID" value="XM_025665445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QQG1"/>
    <dbReference type="GeneID" id="37168847"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24975">
        <property type="entry name" value="UBA_Rad5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="521"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="907"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="1011"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="152"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="161"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH51707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1213" mass="136113" checksum="F5FC8E110058B963" modified="2022-01-19" version="1">MNIHHHDDDRPLKKRRFFADDEDHLTPQPSTDSVTASLHTPASSSLTDQAAQLQPTRSENGPEIIDVPWPDSSSRVEGHTVPQVEPEAVQGEHNAIPRRTEDALPRVDYDGFDVSTFTSIIGERLSADSIQNIRNAAGDDLERAVNIYFDGSWKKSPAPRAQNQTTLTARQRPLSAQSHRTSTPLSASSHPRTQTPTPDKATTRPAAQPPLRYIGAFGVGAWATRSGSGFLRHGDLVNIERTRSQPLSKRNRAGKLVSNQKSDFLTRFTTKSGQEIGRLPREIAEWVSTLLDQRVCTFEGVCVYVPDRVRVNDTIYLQLRCYLRIEAFQPRIFSQSMDDNRSVAYFEEKESADEKALRLRQVALVKLFDEIHLQPTSTNDMTRNHKKEGLLRAAEMAEQHERVKKENQANDDSSEEDSPELEEDQLDTLYKKAQSFDFSMPEAEPASSFTMHLRKYQRQALYWMLAKEKDNKSARETSLHPLWEEYSWPSRDVDDKELPAVDGIDHFYVNPYSGELSLDFPVQEQHCLGGILADEMGLGKTIEMLSLVHSHRITPQKPSNLVRLPQSASGAVPAPYTTLVVAPTSLLSQWESEALKASQPGTMNVLMYYGADTKINLRDLCASGNAAAPNLIITSYGVVLSEYRQYMSALLSSMSSGGLFSVDFFRVIVDEAHVIKNRLSKTAKACYELKATHRWVLTGTPIVNRLEDLFSLVRFLKVEPWNNFSFWKTFITVPFESKDYVRALNVVQTVLEPLVLRRTKTMKTPEGEPLVPLPRRTITIEEVELPDQERQIYDLIYTRAKQTFNHNVEAGTLLKSYSTIFAQILRLRQTCCHPILTRNKAIVADEEDAAAAADATNDLKDDMDLQELIDRFKASTEAAESNEPQDSSAKFTTHALKQIQNDASGECPICSEEPMIDPAVTACWHSACKKCLENYIRHQTDKGMDPRCFSCRAPTTSRDIFEVVRHETPNATPEDDIYSSTPIPSQAPPRITLRRIHPLSPSAHTSAKVHALLAHLTRVPANTKSVVFSQFTSFLDLISPQLTRAGIHHVRLDGTMPHKARAETLAQFNRAETFADQTDIDNDVEANDSAQLPLSKSKHGNSTAPAPPTVLLISLRAGGVGLNLTAASNVFMMDPWWSFAIEAQAIDRVHRMGQTRDVQVTRFVVKDSIEGRMLRVQERKMNIAGSLGLRVGGDGSEDDKKKERIEELRLLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRL5</accession>
    <name>A0A8G1QRL5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_507769</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510229.1">
        <property type="nucleotide sequence ID" value="XM_025664417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRL5"/>
    <dbReference type="GeneID" id="37167819"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="365"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH52307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="711" mass="76561" checksum="4D5E2A5B0F833593" modified="2022-01-19" version="1">MEHIKLSFAKAKHQNRAALGAYVTAGYPTVEETPDILLSLESSGADMIELGMPFSDPIADGPIIQEANMIALANGVTIAGVLDMVREARRLGLKIPVLLMGYYNPVLRYGEEKLLHDCKQAGVHGFILVDLPIEEAVRFRRLSATHGLSYIPLIAPSTSIPRMKALCSIADSFIYAVSRMGVTGASQSLSANLPEFLDCIHTYARDTPIALGFGISTREHFLSVQALTEGCIIGSQIISNIGAAPSGRAAEYVGKYLSGITGRRLERDEQGAIVREVTVLEPPVTGARPQAMAAGGSYADTTDLTPEQNPVASTRFGEFGGQYVSESLMGCLSELDRVFEAVREDPAFWEEYRSYYPYMGRPSGLYFARHLTEKVGGANIWIKREDLNHTGSHKINNALGQVLLARRLGKRRVIAETGAGQHGVATATVCAKFGIECVVYMGAEDVRRQALNVFRMKLLGAKVVPVTSGSRTLRDAVNEALRAWVKDVETTHYILGSVVGPHPFPTIVRTFQSIIGQETKEQMQQAIGKLPDAVVACVGGGSNASGMFYPFIDEPSVQILGVEAGGDGLDTSRHSATLSGGTKGVLHGVYTYLLQDEHGQISETHSVSAGMDYPAVGPELSSWKDSGSARFIAATNSQALAGFRALAMYEGIIPALESSHAVYGAIELAKEMKKGEQDIVLNLSGRGDKDVNTVAEALPRLGPEIGWDLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS17</accession>
    <name>A0A8G1QS17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_344644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825093">
        <property type="protein sequence ID" value="RAH51792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509714.1">
        <property type="nucleotide sequence ID" value="XM_025655466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QS17"/>
    <dbReference type="GeneID" id="37158868"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH51792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="66" mass="7704" checksum="920738FFA73CCEAF" modified="2022-01-19" version="1" fragment="single">NKGLRQWLQIDSQKQQAFSILKIHLLIKWSGINWVREACTSRQRYEGQFPGSQGGFPMRRKATKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSK3</accession>
    <name>A0A8G1QSK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1212 domain membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_165166</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511005.1">
        <property type="nucleotide sequence ID" value="XM_025654257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSK3"/>
    <dbReference type="GeneID" id="37157659"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF10">
        <property type="entry name" value="DUF1212 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_3G01440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="628"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="704"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="762"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="4">
        <location>
            <begin position="353"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="4">
        <location>
            <begin position="634"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="798" mass="87431" checksum="688259542854978C" modified="2022-01-19" version="1">MSEGRRSNESSSSSLISYHSVERPNADFDVEKRHDLTPESDSSRSGHRTHRVHFGADRRFEYGIWDADERVLSPGTSHLRRRSSTQASVDITDVSHRGPQSTSTNGREEENEKKQQQTTTSEKRPRRERLKAFRDSIKEKAANFAARLGRPDDINEDDLQPIDHRRRDTEPDLHSREEGQDQTCSTEAHRIIRELAHEASGRRPSARRESALHRAAGVSAHDEDSGNEAIPRRSSGSGGVLSQLLRLSGGWDQFHKGARGLHLASDTFYPFGGSTPGTTTPRKEKVRWYKKPGNVSTSTLVGGGSASGASTPVTGELLSAASRRRDKSRRHSMRLEEEIQVTLQIAEIIARQRYIMQLCKALMRFGAPTHRLEEYMRMTAKVLDVDSQFLYVPGCMIMSFDDSSTRTTEVKLVRVVQGVDLGRLADTHNVYKNVIHDMIGIEEAGNELEELMAKKPRFNRYFIVLIYGLATAMVGPFAFDARPIDMPIIFFNGCLLGCMQHILAPRSVLYSNVFEVTAAVLTSFLARAFGSIKSSSFTNGSNDYIFCFSAIAQSSIALILPGYTVLCSSLELQSQQIVAGSIRMVYAIIYSLFLGYGVTVGTTIYGLIDKNATSNLTCPTTGGFGNAYAQRFPFVAAFSLCLLIVNQGKWKQSPIMIAISVAGYVTNYFVSSRLGNNSQVANTVGAFTVGVMGNLYSRLWHGHAAAAILPAIFVLVPSGLAATGNLIAGVDTADEIRSNVTKNATGSSTTSSSSSSDMSTNILGFGMIQVAIGITVGLFVAALVVYPFGKRRSGLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QST5</accession>
    <name>A0A8G1QST5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_452875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the germin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511558.1">
        <property type="nucleotide sequence ID" value="XM_025660925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QST5"/>
    <dbReference type="GeneID" id="37164327"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000150">
        <property type="entry name" value="Spherulin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034508285" evidence="6">
        <location>
            <begin position="24"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="7">
        <location>
            <begin position="52"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH53636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="235" mass="25608" checksum="B98B2D8180D4DB4E" modified="2022-01-19" version="1">MIFSFSLYFDLTIILALVLQARAVPHPVAKRSNSDLSLTAQLRLADTAIERYKLLPNDSDFVFNFTGTEQIPVATSQNWPALVDVGAAISMSQLPACSMSFLHLHPRATELFALNSGHILSEMVPQAGVLDSNSSQRVIRTDLRPGQVTIYPAGSFHTQVNPDCEPANFTAAFTSDEFAVSLVAEQLFSLSDGVIARTFGQSITGDDIEKIRKAIPSDMAIKVEECLTKCGMAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTA2</accession>
    <name>A0A8G1QTA2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Terpene synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_452998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511380.1">
        <property type="nucleotide sequence ID" value="XM_025660966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTA2"/>
    <dbReference type="GeneID" id="37164368"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016102">
        <property type="term" value="P:diterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739:SF25">
        <property type="entry name" value="(E,E)-GERANYLLINALOOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739">
        <property type="entry name" value="ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="606"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="895" mass="101137" checksum="297C94E9783C8839" modified="2022-01-19" version="1">MAALLSLLRHRTSLATSNEHKEEARDLDERIFRAMAFLRPKLQLADVASVDRVGLELLIPAHQRLLQEEGVFLDFPGAIELNRLREAKLARFSPEVLYGSTPTTITHSLEAFIGVVDFDRIRHRLDFGSMLASPSSTAAYLMSSSQWDNTAEAYLRAAVEHGAGQGSGAVPSAFPTTTFEVVWVASTLLQYQVVLGDTGQQCLQTIGQYLNHIYERQNGVFGWAPTLIADADDTARGVLTLNLIGYAARPEQLIAQFRNHDHFRTYPQERDPSISTNCNVLAAMLHTTEPYQYIKDIELTLRFLYRQHNAGHFQDKWNISPMYPRMLLATVLSRVTQLWAKGPLASLALDCVQTAFVVLSNLLQKTLMEQDQATGSWNKSTEVTAYSVLTLAAASNTPAGAVVGEKLRTSIIYGRAFLEANFQLWGHDRPLWIEKVLYSSPLLSSGFCIAALLTPTFTMQVASNEDGVTTRVPSNSLLHFRKFYSRLPLLSAEPQWRLTSSLYEAELWYHRLADQRHEIFPRDNMAPDKYLQYIPQTWTLCNARNGDALEPDLMWNMMIISMLNYQVDEFLESVVGAYTAEEVNVVRNIIHRLCDDEQHHRESPLPNLLLQGEDPSSDEENSDIHLRRSEPTPPESPKDGNANHTLAHASHILYKFTRYILSHPAVAHSPVNTRRLLARELETFLQAHLTDLVTSQQLHQSLPYLHLHEQLAKPPSSYFTWVRTTSADHTSCPYSFHFFAALVAYYHRPPDTSAPQSAFYGPRQRYLAESLCRHLATMCRQYNDYGSISRDIVERNLNSVNFPEFWEQVGDGKIADTHNDGGDHGKPTDKSLDAVKADLIWLAEYERACCMGALDRLVNETGLPTRTARILQTFVDVTDLFGQIYVARDIASRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTB4</accession>
    <name>A0A8G1QTB4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_523838</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511211.1">
        <property type="nucleotide sequence ID" value="XM_025665382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTB4"/>
    <dbReference type="GeneID" id="37168784"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF10">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH53289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="517" mass="56311" checksum="52F1EEA9C01E8C5B" modified="2022-01-19" version="1">MATIHDNDELLLARIGYKQELKREFSKWSTVSYAISILGILGSVPATFGAPLAAGGPATAVWCWFVGSCMALCIGSSVAELVSAYPTAGGMYFVTKHVVPDEHVPIFSWVQGWCNLLGQTAGVSSVAYTVSQMLLACASMNSELVDGEYSYSPSAMDTVLLSVILLCLLGVICSMTTKSLHQIFLWFAPINIAATFCICFSLLWFTPDKQPATWVFTHFTDGSGWGSKVFSFLLGFISVAWTMTDYDGTTHMSEETHNAAALGPLAIQWAVIVSGILGWILTISMCFCLTDYEGILNTPTGLPAAQIFLNAGGKLGGSAMWGLAILVQFFTGCSAMLADTRMAYAFARDEALPFSSFLSQINPYTQTPVNAVWFVVFFSICLNCIAIGSTHTATAIFSITAPALDLSYVSVILAHQIYRKQVKFVEGPFTLGRWGPYINWVSVTWVMFISSVLFFPPTVPVTVSNMNYGICVGIFIAAFALVWWWVAARGRYTGPRTTEHMQPIPTEEPGLDYGTMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUG8</accession>
    <name>A0A8G1QUG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_491321</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511980.1">
        <property type="nucleotide sequence ID" value="XM_025663707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUG8"/>
    <dbReference type="GeneID" id="37167109"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF115">
        <property type="entry name" value="DIHYDRODIOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="153"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH54058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="389" mass="42345" checksum="8CAA58CE9313416C" modified="2022-01-19" version="1">MSSHSVPVPFGLRWGIIATGSIAETFAKDLLIHPASRGVTDVSHLLVAVASSRSTEIASRFINKVGAPSSCIAYGSYDALVADPRVDVVYVASPHSHHYQNAMLGLQAGKHVLCEKPFTVTARQAHRLVETARARELFLMEAMWTRFLPISAQIRQEVQNGAIGPVIRIFADNSIGTNALKELKDSYLTKKELAGGALLDLGVYPVHWIMQTLAPRPDPKPSSILSAITPLLGAGVDESTTILMTFPGTSPSPVSVQAIASSSLRAMADPDGHTPVVRIQGDSGEIQIYGRPWCPSKYRIIKRVQQFGITGGEEEFEYQVPGGAHGLCFEADEVARCVRDERLESATMPWTESLTVIEILDAVRRAHGLFFSEIVESEEYPVNMPAKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVS6</accession>
    <name>A0A8G1QVS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_471741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511679.1">
        <property type="nucleotide sequence ID" value="XM_025662500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVS6"/>
    <dbReference type="GeneID" id="37165902"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF113">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="26"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH53757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="374" mass="41027" checksum="A81D3EB447E588A3" modified="2022-01-19" version="1">MTVNRNAAVRAVPAVFLAVTSITVLLRCYVRLRLVKAFGWDDGLMVLAMAVYAMFCGVMIGGSLYGTGKHFADLTTSHRVTAMKYWWLCEIGYCFSSIFCKCSICIFLTRITIKRPHLAFLYIIMTCTVLMGLVLMFSLLLQCRPVSYFWTRVAFDPTVEGTCVKTELVIALTWAYSAVAACCDLAVGIVPYFIIRKLNMPWRRKVAAIGISSIGCIACCAVIVRIPYVPTFADPDFLYATYEVAVWSNVEVGLGIFAGSMATLHPLLKHLRTFFTKPGMTRLSSRSSSGPGPTAPKADFVSVSSYPSAPVTLFRPGNVVNMTTTIQGDGAGVAHPDSCSPRASRDTGRRTNDILIQQTFNLDTGWDSRNSSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVV6</accession>
    <name>A0A8G1QVV6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_151757</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511724.1">
        <property type="nucleotide sequence ID" value="XM_025654152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVV6"/>
    <dbReference type="GeneID" id="37157554"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH53802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="320" mass="35623" checksum="37DA7075E9F143DD" modified="2022-01-19" version="1">MTNCTTDWSNVTLATFNQTLLNDTSLCTKCTCPLVLDGEQLSWVRYYPNLAGNVLYAALFGLFLVLQLFFGIQRKTRGYMIGMTLGLILEVLGYVGRILLRYSMFEFSWFLMYLVPLTIAPAFISAAIYLTLSRIITIYGAEHARFRPQVYTYIFITFDIIALLLQAVGGAVASIADAYSSMQDQGVHVMVGGLAWQVVSLFIFSCLALDFYLRVNRASRKGVPLNPAFDSLRAQRSFEPWFIVSLSLAVLFIFVRSVFRCAELQGGFGGELANEEITFMVLEGAMMVLACGLLTFFHPGLILGAREWALAKWSRGGKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWB0</accession>
    <name>A0A8G1QWB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_490509</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512771.1">
        <property type="nucleotide sequence ID" value="XM_025663663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWB0"/>
    <dbReference type="GeneID" id="37167065"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="13"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="342"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH54849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="444" mass="49665" checksum="77420042D502953F" modified="2022-01-19" version="1">MSSSSSNVVGVHYRVGKKIGEGSFGVIFEGTNLLNNQQVAIKFEPRKSDAPQLRDEYRTYKILVGCPGIPNVYYFGQEGLHNILVIDLLGPSLEDLFDHCNRRFSIKTVVMVAKQMLSRVQTIHEKNLIYRDIKPDNFLIGRPNTKAANVIHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFLYFLRGGLPWQGLKAATNKQKYEKIGEKKQTTAIKDLCDGFPEEFTKYLTYVRNLGFEDTPDYDYLRDLLTQALKNAGEVEDGEYDWMKLNNGRGWEYKSYSSQQHLHNNALPNTSARELHAQQLRGSRPGVTADRLNAAQPPPPSPAKPGAGKTRDRPSVSGGMPPKRQSGGLDATPTASTQAQFQNSNANIPGRLDSPANPTKNSQQGQGAQGNNEPQPTFVQKLMKALCCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWG4</accession>
    <name>A0A8G1QWG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyceraldehyde 3-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_522736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512764.1">
        <property type="nucleotide sequence ID" value="XM_025665289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWG4"/>
    <dbReference type="GeneID" id="37168691"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="410" mass="43669" checksum="C9727A95435E7F5F" modified="2022-01-19" version="1">MSGLKGVMKEGWHPKGKDGKKESWRNDFKGINQVAGWMGKGKDNTNDREEHVSAPLSSLKDPASFGPPPKHIKYHGAAALPNETTPDRRGLGAPLPQEQIDRQNAQMQEQQQQMQMQEEAAQKPAPPPLPYRANRTGLDTSNLPPPPVRRMGSPADPIPPPSSRPKPNLPPRLPSRNNSTPSPHPPTPPPAYSPHSQTPSHAEEYINQGAASRLSQAGVSVPALGIGNNAGQWGRESSSPGSASPAMAGSVGQAPVNELQSRFSQLRTTSSSSPAPPPPPARTYTNGSTAQSVSSPEPRSGSSTVSEFRERHNDKIQAGKQKLNGLNEKYGISQRVNKFFDDQKTPSTQAPPVPPHPNANSSTSSVDTDALSKRKAPPPPPPPKKAGMRSTPVAGSAPTPPPLPLNTKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWY6</accession>
    <name>A0A8G1QWY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_452000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH55097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513019.1">
        <property type="nucleotide sequence ID" value="XM_025660720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWY6"/>
    <dbReference type="GeneID" id="37164122"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="677"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="632"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="729" mass="82818" checksum="9774B75A9AF600A4" modified="2022-01-19" version="1">MQGLWSRAAPAQSTCRCVSCLSTVSNGVASRGTSAASKKRLRLGNSVTALYTSIFAAAALADAQAKGQRRHEWEEKIAAVKEEVIELVDEEQRLVEALMSRRKQGFLNGTLQTRQFSTATRPAPMRYQWPRRNAPFASFHSTTAFANERDNQIIRDLVAESEDPLAEDANEDYGLSLEDDDTPTWLTGDVVRQKVIRKLALKQLAIRLLLRPAIAHSYQGVQMNYSADFSIPQLRVPQLLAELNSLRRRMRQVKGSEKANIDDLAKDLRVHSIRHMTEERNRLDRDVQRDTEIYMRNEMPLQELLLRLANNLMQCTDPDRPEVIKKMILAFTKTRQNDLCDLILKTILPHKFPLSASLILTILTFFRKSKNLMGFDIFLEMLNGHGYPVDMNGLGLYQRQVVNGVEIIVPPVDSANPVIYATLIVSCLRFDQPDRADAYLLAARSAGHMDDFAILNSYLRFCAIRTDWEKGVQTLKRTLAFMVSSTEHQLFRLERLIVLMVHMCDACEQYDMSEAIITSAMNSGFNWEAASKQLDIKSSHDPHHNRWSSAAEAAPKDMQEKLAWEKAYAFVNVMNERLSAYEGKSPSKKWQDMIELYSQQVLTAMLAGSPASANAPKVPEQVFEDKDRQSLLQEISRQVEKAKKENESTAAAQEQEITSLKAEISQLKQMVFDLHQTRKQESTIPSPPPSPPRSTHHQDHLLRRKHEHIAPAPELESSFNKVSIRYMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWY9</accession>
    <name>A0A8G1QWY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 alkane hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_441466</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512448.1">
        <property type="nucleotide sequence ID" value="XM_025658808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWY9"/>
    <dbReference type="GeneID" id="37162210"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF17">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH54526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="508" mass="57718" checksum="8F9E622726F31954" modified="2022-01-19" version="1">MMESNNTHILTIAVGAAVVFFFCLIKNLRCIWIQSQFAKVHGCEPVLPASKDPLFGIDVLLENIQAAKSHRFLELIQHRFQRYGNTFRVKRFTTPFIITCEPANLKGVLSLNFRDYGLGSRIATFGPLLGRGIFTSDGEHWAQSRAMVRPNFVKDQIADLEKLEELMQGLLALIPTDGSTVDLQDLFFCYTLDSATEFLFGHSVQSLNQRLSGVVPDDSDFASAFNYAQHAIARNTRLGFLGRVIPDHKATQSNRICHSLVEQFIDKALKYREEYAKKGSNDEGRHTRYLFLQGLAEQTGDRDRIRDELMNILLAGRDTTASLLSNLFFMLVRRPKIWKKLREEVATLNGRAPTYQQLRNLTYLKHCLNESLRFHPVVPVNSRKALSNTVLPVGSGPNGKSPVFVRKGTIVFYSVWAMHRRQDLYGPDANEFRPERWADLRPGWEYLPFNGGPRICIGQQYALTEAAYVTVRLAQQFSTLETRDPGPWEEALTLTLCSRNGTKVCLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXQ2</accession>
    <name>A0A8G1QXQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_489124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514243.1">
        <property type="nucleotide sequence ID" value="XM_025663581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXQ2"/>
    <dbReference type="GeneID" id="37166983"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="122" mass="14111" checksum="8A577808F5D0ECB8" modified="2022-01-19" version="1">MANISIVEADHERVEFPTTANGLPTGFPPVLARRGAPEFMWDQDMYIIRHMAERLSKDQSREIFLVCFTCGLSICFYGAAVDRFNDRLQTYVDGMNARYAPYGVVWEMRWVPYCGTFMSYET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY14</accession>
    <name>A0A8G1QY14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peroxisomal membrane protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_450528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514423.1">
        <property type="nucleotide sequence ID" value="XM_025660393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QY14"/>
    <dbReference type="GeneID" id="37163795"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013674">
        <property type="entry name" value="PXMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH56501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="217" mass="24524" checksum="B0FD5E5F28AFDA91" modified="2022-01-19" version="1">MDALMSRLDSLVTNPDLAPLLALVKGVRNGAVYGAKVRFPHALVMIFLFRSGTIREKVKLVLKATRQHARNLATFALIWKGVMLALRNINPTTGGKEGRYDSFMAGLVGGYVVFGRHKTSITQQIVIYVFARVMLAMAKLAVRPNMHPLSSTITPDARSKMESNAWPVFASLTWAFVMYIFRWHPDTLMSSLRSSMVYIYADSDHWDSFRNFLIHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYB5</accession>
    <name>A0A8G1QYB5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_450058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514573.1">
        <property type="nucleotide sequence ID" value="XM_025660293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYB5"/>
    <dbReference type="GeneID" id="37163695"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="87" mass="9922" checksum="5F3950BCAC65336E" modified="2022-01-19" version="1">MHQMLIGRSRPVVGNISQRLQSADPTQRRRHIMRSDTYRKDSSEPGHIPVSSLRVHGAAWAVAGASMYATLHGVYMMLKSFRQIRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYK5</accession>
    <name>A0A8G1QYK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_489402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH55998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513920.1">
        <property type="nucleotide sequence ID" value="XM_025663601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYK5"/>
    <dbReference type="GeneID" id="37167003"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="194" mass="22475" checksum="41889241892B0946" modified="2022-01-19" version="1">MESPHKIFLIPEVLEQVLVKLDATTLLLSQRVCHLWNSLIKTSPTLQRALFFRPERQPPTEEQNPKRTTNPFMDKLLKHFVSNPRLVDSTQDSSNWLRPFMPLQTTNHPRLGRNHPYSRPEASWREMLLDQPPTPSIAVRDDLIPLRPFGVLCEERKSVIRLKHLETLAQSSFVPRVGLMSTKIFGKSSHLYHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYL2</accession>
    <name>A0A8G1QYL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_427631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512462.1">
        <property type="nucleotide sequence ID" value="XM_025658164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYL2"/>
    <dbReference type="GeneID" id="37161566"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000054">
        <property type="entry name" value="DCR2p Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="218"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="551" mass="62279" checksum="CA5F59032C99571F" modified="2022-01-19" version="1">MTRRLVRAGVQLAIFASFIALLVVTLDNRFRVLPASIHGHLPSHYAGFAITDVTIVTCSSINVFSNCQPSQESWSQVEKDLYLRTGWTSSAFVRFERKKEEELLPTDKVVIDLKISRLVPEYSEDPEAQAETWEQRPGGIWLKRTAKRHASDSGKAITAIDVLFGADAVDPRIGWEVRDTPLLLDSRTEELETRISVRRGDPPKTKKPVPRINENGRFKIMQLADLHLSTGLGACREPVPAEPVPGQKCEADPRTLEFVERLLDEEQPDFVVLSGDQVNGETSRDAQSALFKSVKLLVDRKIPYAAIFGNHDDEGNLKRPELMTILEDLPYSLSTAGPEEIDGVGNYYVEILGRGSTTHSALTLYLLDSHSYSPDERNYRGYDWIKPSQIRWFKNTAQGLKTKHHEYTHMHMNMAFIHIPLPEYRDPNNYYRGNWTEAPTAPGFNSGFKDALEEEGILFVSCGHDHVNDYCMLNRDNEEKPSLWMCYGGGAGFGGYGGYGGYVRRVRFYDFDMNPGRVVTYKRLEYGETEAKIDEMMIIDGGIVKGPEQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZ62</accession>
    <name>A0A8G1QZ62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA endonuclease activator Ctp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_451340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513479.1">
        <property type="nucleotide sequence ID" value="XM_025660570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZ62"/>
    <dbReference type="GeneID" id="37163972"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="6">
        <location>
            <begin position="558"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH55557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="600" mass="65841" checksum="AEE24BDCB3DA3928" modified="2022-01-19" version="1">MEALEQFQISLTQAFGDCFKDVYKTLQRELALRDAKVQAAEERVRIADEARKRADAELTALKDEITILRDELRLGDVGSTEDQVTAQKSLELEATYAPHRAIDRICANRKDSESFDSTEIMAVRDLYAALYTEAQTLMKASGELRRQIKRHKKKLMHWRKSLDRDNFTLVLDGEAVDFQRAKRNSCEEHSRLFTNLSTSIPINSSKSAMHPVLRGASAPIMHTSGLGDYDESSNADVPREPAAAQSATAPAATIKRKRSASQPPHQICPTLHDNAPNHGNSGSSQPISIRDEGLSSSPLGGSLSSCGATGTQDLDEVGVLVQTPTKRKKYKEIGSERAASPAIEARRKGLPPARSQSFSRRPTILQSVNGNTSINRYDQRLGTAAAKGSKPRLKYPISAMAEDGEENDVNVATPNRLNTSAFEARSPLPDPGKEGQFAVQRLEGLLEGPVPAKQQLQPKNINEEFTRGCAVQRSPSVGRTLSNNSRGGQTNSESEIMQGSSKLDIQHDFTQATSSSGSEAQRVKENATRIPYRTLPLHRLELTHFRINPNYNQGVNFAFSSVIRTTDERKCAKGCMRPSCCGGRAEESGGLFGRGSTYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZA6</accession>
    <name>A0A8G1QZA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">dTDP-D-glucose 4,6-dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_452449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511977.1">
        <property type="nucleotide sequence ID" value="XM_025660823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZA6"/>
    <dbReference type="GeneID" id="37164225"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000304">
        <property type="entry name" value="UDP-glucose 4,6-dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="26"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH54055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="362" mass="40936" checksum="A86930A9E4E90ECC" modified="2022-01-19" version="1">MTVQQRGLGSNGSDNEDAMGSVKTILVTGGAGFIGGWFIRHLLQVYGTRYTVLCFDILDYCASKCNIHPVEHLPNFHFFGGDLCDPDRVTAVFQQFTVDAIVHFAANSHVDQSLVNPVSFTRNNVTGTHVLLEAARQAGTVVRFIHVSTDEVYGENRPNQDYAFTEEDRLNPTNPYSASKAAAEMIANAYRYSFHMPIIITRCNNVFGPCQYPEKLIPKFAMQMLRSQRMTLHGEGNAVRGFVFAGDVVNAFDLILHRGLVSETYNISSKEQLQVIDVAKRILRWFHAGPSHACEQYLETVTDRPFNDRMYWTDDSKLRQLGWEEKVSFDDALTMTLEWYRDHGETFWSDPGPACKWNGRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZC3</accession>
    <name>A0A8G1QZC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_451817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512852.1">
        <property type="nucleotide sequence ID" value="XM_025660677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZC3"/>
    <dbReference type="GeneID" id="37164079"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016814">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052349">
        <property type="entry name" value="Metallo-hydrolase_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027:SF0">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="460" mass="50645" checksum="BCF8C4691ED6709C" modified="2022-01-19" version="1">MPPPTLTPVKRIQNVRLPGRDSTWDIDISRPHDSPHSIITSITPHPNPEWNQTAPLALPALTHPHIHLDKAFIHNSPEYAHLLPSTGSFAEALSFTTKAKQQFSRRDLLRRGEWLIAGSVSAGVTAMRAFVEVDHTVNLTCLEAGIALKDEWKEACAVQIVSFAQDPIFSGEHGNHNRRLMEEAVQQPQVDVIGTTPYVESSIDASKQNIIWAIERALECRKHVDFHLDYNLDTGKEALVWFVLRTLKERGWTSQSTDKRVMLGHCTRLTLFSDEEWGLLAQEIRDNDLPVSFVGLPTSDMYMASPPSSKSHDRPRGTLQVLEMINKYGLDTVIGINNVGNAFTPWGSEDPLSLACLGVGVYQAGTKANAELLYECVSTRARAAIGLSSSEALALNQGSRADILLFYDVDDTGCNVSRPRHGVAGIVWDPPAKASRELVVGGQLKASPCSLCPKSAFDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0L5</accession>
    <name>A0A8G1R0L5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_373069</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515096.1">
        <property type="nucleotide sequence ID" value="XM_025656064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0L5"/>
    <dbReference type="GeneID" id="37159466"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000141">
        <property type="entry name" value="C2H2 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000243">
        <property type="entry name" value="Probable transcription factor steA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="487"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="396"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="574"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH57174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="611" mass="66551" checksum="558EBE26FFA07A6E" modified="2022-01-19" version="1">MDGTYTMAPTPVQGQPSFAYYPDSQQRQHFTSHPSDMQSYYGQVQAFQQQPQHCMPEQQTLYTAPLMNMHQMATTNAFRGAMNMTPIASPQPSHLKPTIVVQQGSPALMPLDTRFVGNDYYAFPSTPPLSTAGSSISSPPSTSGTLHTPINDSFFAFEKVEGVKEGCEGDVHAEILANADWTRSDSPPLTPVFIHPPSLTASQTSELLSAHSSCPSLSPSPSPVAPTFVAQPQGLPTEQSSSDFCDPRQLTVESSINATSADLPPLPTLSCDDEEPRVVLGGEAVTLPVHETLSPAFTCSSSEDPLSSLPTFDSFSDLDSEDEFVNRLVDFPPSGNAYYLGEKRQRVGTTYPLEEEEFFSEQSFDESDEQDLSQSSLPYLGSHDFTGVQTNINEASEEMGNKKRNCRKSLKRASTSDSETDSISKKSQPSVNSRASSTETNSSTPQAVQARHNSDAHSCASEAPAAPVSVNRRGRKQSLTDDPSKTFVCTLCSRRFRRQEHLKRHYRSLHTQDKPFECNECGKKFSRSDNLAQHARTHAGGSVVMGVIDTGNATPPNSYEERDPSTLGNVLYEAANAAATKSTTSESDESSSDSPTVDRRAPKKRKRDSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0L6</accession>
    <name>A0A8G1R0L6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_448997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515803.1">
        <property type="nucleotide sequence ID" value="XM_025660066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0L6"/>
    <dbReference type="GeneID" id="37163468"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000033">
        <property type="entry name" value="acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF11">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04355)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="54"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="145" mass="15594" checksum="DB9732A00777411D" modified="2022-01-19" version="1">MNAELQQVQKVWERIRTNSPIYAFLLQDIDIYDAGKGVFNARLQVGPQHLNSKGTLHGVFSACVTDWAGGLAIASAGLDSTGVSTNIHVNYLSTAKTGDWLVIEGRADKVGRNLAFTTVTISKQTDSNGGTVVAQGSHTKYIKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R169</accession>
    <name>A0A8G1R169_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_460118</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514668.1">
        <property type="nucleotide sequence ID" value="XM_025661699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R169"/>
    <dbReference type="GeneID" id="37165101"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000056">
        <property type="entry name" value="CCR4-NOT core complex subunit Caf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH56746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="488" mass="52690" checksum="97B9EA0EDCBC4185" modified="2022-01-19" version="1">MPPPVGRYGPTGLTASYTHLQQAHLQQQQQAQHHPAHAQSANSALPPPSLGGHPGFAAGNPNTNINPFTLSGTGIANGMSVAGFASAGDGGGTGLASHAAQMGFARGAQMQQQQLHQTHDGRLALEAKAGTVKTRIRDVWSHNLAQEMAILRQFVEKYPYISMDTEFPGIVARPMGAFTNKADYHYQTLRCNVDLLKMIQLGITLFSAEGEVPPPNATDANGQPLGNSLVPAPCTWQFNFRFSLEEDMYAQESTAMLAKAGIDFSMHEKNGIDPFEFGALLISSGLVLLEDVHWVSFHSGYDFGYLMKIMLCKPLPENEEEFHKLLKIFFPSLYDIKYLMKHAGRNQAVNDSPLTPAAAQILTNLGQKSGLQDIADELGVKRVGIAHQAGSDSLVTGEIYWKMRQLVFNGSIDESKYSGQIWGLNGQMPALLYHMQPHQTPNLNGATIYSATGTPSTPNAGHLGSQTPHTMTPGATGGVLGQFQLAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1E3</accession>
    <name>A0A8G1R1E3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_468834</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515314.1">
        <property type="nucleotide sequence ID" value="XM_025662296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1E3"/>
    <dbReference type="GeneID" id="37165698"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF16">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034842258" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH57392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="581" mass="64674" checksum="A0AD41F49FFC7956" modified="2022-01-19" version="1">MRSHHLWAAALALTGTVQATTLQDVCTVSFARSSLPDDSVYPGVSIDRSSVSAVAAYNVSSTDQVYWPGATFDYCNVTFAYSHLGRDDRVVVSYWMPAPSKFANRYLSTGGSGYDITLGSTSLPGGVMYGAVAGTTDGGFGGFENGSDDVWLLANGTLNYETVYMFGYQAIHELTVIGKELTKKFFNTSSIYSYYQGCSEGGRDGFSQIQRFAEDFDGAVTGAPGFRFTFQQMQHLWSPVVEQTLGYYPPPCELEKIVNETIKACDALDGKEDGVVSRTDLCKLHFDANSTIGEPYSCGASSLTTYKRRKRSETYALPAQNGTVSPQGVEVAKEIMRGMHDTKGKQVYFSYQPSAAFSDAETHYDYDTGSWTLDITESNSEWVEKYINLLNATEMPTLKNVTYDNLKEWVRIGWQKYDDTLQATYPDLSPYSEAGGKVLHYHGESDYTVPTASSVHYYESVRRIMYPDMSTNASYAALGEWYRLFLVPGAAHCGPDDSQPNGPWPQKTLETMIRWVEDGVFPEMLNATVLQGEHEGEEQKLCAWPLRPLWKNNGTTMECVNDPEGMKTWVYDLNAFKMPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1P7</accession>
    <name>A0A8G1R1P7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_425875</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513222.1">
        <property type="nucleotide sequence ID" value="XM_025658097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1P7"/>
    <dbReference type="GeneID" id="37161499"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000484">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="18"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH55300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="545" mass="58276" checksum="313AE5D9FAC4E166" modified="2022-01-19" version="1">MEAQPSSSSSRGWRFWLIIAGCAVTSLLTAVESTVTSTALPTISRDLNAGESYIWFVNAFFLSSTAFQPLYGQLADVWGRRWPLISAVAFFALGSGISGGASSSGMLIAGRTVQGVGLGGVNMLVDIVVCDLVPLRERGQIMALIFVVFAVGSSLGPFIGGAFTENVTWRWSFYISLPIAGAAIGLMLLFLQVKYQKNTTLVQKLKRIDWLGNGLLIASVVAILIALSFGGTTYSWSSWHVVVPLVLGLLGLLVAFPAIQATPKLCPEPTMPLRLFANRTSLAAFTLTFLHGMLLYWTIYFLPVYFQGVKSSSPIRSGVQLLPTVIVTVPAAIVAGVVLTKTGRYKPIQIAGFVFMALGMGLFSLLDKNSSTGAWTGFQLLAGIGSGFVITSTLPAAQAELAETDVAASTATWAFLRSLGSVWGVAIPAAIFNNQFASRVAAAGLDKDSRIAAILNSSGAYEQASGDFVSTFPNDVQPAIIEAYTGAMQRVWQISVVFAGLGFIIAWLEKEVELRTTLESEFGLKEKDQMEEKDDLGVVEEGPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1Z0</accession>
    <name>A0A8G1R1Z0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_370812</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515861.1">
        <property type="nucleotide sequence ID" value="XM_025655974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1Z0"/>
    <dbReference type="GeneID" id="37159376"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:heme binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF112">
        <property type="entry name" value="L-ORNITHINE-N5-MONOOXYGENASE (EUROFUNG)"/>
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        <property type="entry name" value="EP450I"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH57939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="555" mass="62809" checksum="8AA3F5D2E905B178" modified="2022-01-19" version="1">MVSSTLTAALVGVFSHLTYFRRGEHQLYGTTYTQVFCVLCATSVAYLHVSWGTAWREALVTVSLHAASYLLGTFSSLLLYCLVIHPLGSFPGPWLARVSDLWLVSQMKNNNKHVKLVELHEKYGPYVRIGPSTLSVIDPKAVNIIHGPASRCLKSGWYDHSYPNKSLQTSRDPAEHQQRRRLWSTAFGSKQLRGYEHRVRRYRQQLVDRLMEREGQPVNVTKWFDLYTYDVMGDLAFGEGFGCLEQGEYHWATQIMMETMDFVGSYLPMWLFRMVLEVPGLKRGWYKFLDYCEMRLVERMRVSSYRTCIASTELTRQNEPDVPDVSAALLAPFKGKEPGKEDQQWLGGDSRLIIVAGSDTTASTLVALFYELAHRPDEVEKLRAELAPSVNKDGGLGDFYDGDIGHLGHLNGAINEALRLYPPVPSGVPRIMPPDGITVNGVSIPGNTIVINPTLAMGRSELSYKKPLEFIPERWYQQPELINDQSAFVPFNIGTYNCIGKPLALQNLRATVAHLVTTFDVKFAPGNAEKDLIRRSKDCFVLYHDELDLIFTRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2D6</accession>
    <name>A0A8G1R2D6_9EURO</name>
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        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_300004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="RAH57391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025655335.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="37158737"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="LysM"/>
    </dbReference>
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        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33734">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING GPI-ANCHORED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33734:SF22">
        <property type="entry name" value="MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033985696" description="LysM domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="47"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="121"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="235" mass="25288" checksum="3ECBCA4E8A8D36B6" modified="2022-01-19" version="1">MLPGPNKLFLLTAALFGHAIALPATVDYDVLPSTGSVLNLDVAASNITYTVQGNDTIHTIAAKYNVGACDLARLNVLSDPNFLYENETLRIPARATFPDDYSCFSTNNTDATATCIYGGPHVYTILPGDTVQKIANERYNITTDSILSFTAQTGYIAALNPGIYDVLETGQTVKIPSCDNSACTMADFTFTYGTLQDFATAYNVSVGQIMSLNLGYNHTDYIAPLGVVYDCTLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2U0</accession>
    <name>A0A8G1R2U0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_35829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515146.1">
        <property type="nucleotide sequence ID" value="XM_025655499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2U0"/>
    <dbReference type="GeneID" id="37158901"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1046" mass="112752" checksum="2C888BB72B4A75D3" modified="2022-01-19" version="1">MPPSTVFAYWRREHRRSSASPVSPSLQPTSKAPVTSNPPQLPELSNTRPNPTALGTSSVESSSPQVPNNPHEDYYDATKKTIAVSVAPANAPGSSSANLAIPSSSSDNHTRPISSSDEQDVTITTSQSNYSQSSIAPPRSDQGDGDSPKPSSPFRLSLGKNLLNSHNLTSDHHNKRSSTPVLSSSGHFRFRTSSPDISPGDRMASSHKDKDKEYKYEGAGNRRSADRDGPLEQPHHKSGRTRLHLLNPMSLLARRRSSNLASLRTEDTRVGARNIVPAIPDDYDPRIRGNIVHDFSAPRPRRNLSTAPVLKHDVNNQSSPADVTYNGNGNSAHGADQSAQAGEQRKRHTQYSPVFKEHFEDDQKVLQVESKAYLQSSLLTAQSNVENDPHTLPVFARKLPSKIPEQDVSPDVPSDQTTLKQDSQHSPPSNVGAATQEDTDTIEVIPHQPSGLPKHLKSNASRFSFDMNGVESSTQEKLLEEKHKEKEAARRAKARMEGASFSDGEDDFDEDLLDDMDDLEEKIPGVNVDADEDDDFSGFSGPGNALNKPWLAPELSPIIASPLPTGITFSQNIQEPAQGPLAGTSAPLPVSDSVVSDDVTDVTTNMQALSVATNTSNNAAQVSMSSHPPAPQPIEDDDDLYFDDGEFGDLSTEHMGEKFDESIFDDETSHLYERKPVVQQPVPAPAPPPDNGAGSANPLDGTAEHDEFTPEPDYDGGLRHVPSMASDYRKGSIRVYGQTRESLANLGSAKAHGGVLSEHNLEAFHNALAKAASEAAASDRFGRETSVSERSLGQESTAQTMDTPSGLISDDSRLSQTVDMAAFEEVFEDFNYDDNDDALFDDPIIAAANAEALENDDEGFYGQEFGFYAQAHGGCNGELTNGGYFGPRGVEGVSRSFSSRGKFREPSLTPITERSEWSTRNSVISLTAHGAAHSNPIASPGLAQLVDLGAMDDEMSLSALMKLRRGAWGGSNGSLRSSSGSPPLLHSTSNRASFISDASPTIYTAPPDAFCGSATESPIRESDRFRWSLNNTEQRVGQSAGGEKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R352</accession>
    <name>A0A8G1R352_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_521315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513942.1">
        <property type="nucleotide sequence ID" value="XM_025665192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R352"/>
    <dbReference type="GeneID" id="37168594"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000308">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000467">
        <property type="entry name" value="Putative MFS transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="47"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="435" mass="46894" checksum="958F3421D25B778F" modified="2022-01-19" version="1">MSTTTIELVSQGQQESQNPVQPFGPSTEGAIVQQKQKWNDPPINRWRLLATFISFTVVGANDGVYGALVPYLREDYNLSTTVVSLIFVTPFAGYTIATLIVNKIHMTLGQRGIAIIGPLCHIIPYVIMAIHPPWPAMLAVYVIVGLGNGLIDAAWNSWIADMANANAMMGVLQAFYGLGATISPLVGTQMIKSGLRWNYFYYTLLGASVLDLMVSSALFWKEDAASYRAKNHRGTDSGGGSRTTEAMKSPITWLIAVWLFVYMGVEVSVGGWVVDFMVQVRHGEPYESGLIPTGFWAGVTVGRLVLGFVNDWLGERIAISIYLAISIALELIFWLVPQFIVSAVAVSLLGFFTGPLFPAAIVVAAKLLPKHLHTPGIGLASALAGGGGAILPFVAGAISGARGVQSLQPFVLTLLIALIAIWVLLPRRKHHAYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3R2</accession>
    <name>A0A8G1R3R2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_467700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516836.1">
        <property type="nucleotide sequence ID" value="XM_025662209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3R2"/>
    <dbReference type="GeneID" id="37165611"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF13">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN MOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH58914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="549" mass="60623" checksum="FC5D43AD15DF35ED" modified="2022-01-19" version="1">MEGLSNNNSLSTAPQSGNNSSAPSSKRVRVVVSQSKRGCVTCKARRVKCDEQKPLCWRCLQSGRVCGGYSHEAKSSLSSALQPALKCGVTMDSHAERLSYLAAHVLSLDNRGCSPREDSAWGRIFLQLSSQVECVKAAAVAFGAAYESSQINLIGHRPYSTWNYYGSALARLRSDFHDRSVGAESLALASMVLAYVEILSQHEQNAFTHFLGAVQILTQAEQHRWQVSSAKMLSTIKDALVKINLLIGSYGLSQTPQYMYLDFPRVPTGDDEFCEPELAIDAAMHCLYRSYQFIEEASHLRYTYSNWKEHDPTMCKAQSDAAAECRSVLDCLAALVTTLQGRCSSATPTPTPRDLDMLAEIYAIRTQLTSALIFILCAHSPYETSYDEHHDQFQSIISDAAASARLRRRTKPSAFKRFSTRLGIVSPLFIVGIKCRNPSLRSLATALLTEQSREGPADGRILAAIGARLAALETSSSFTPSPSAPLTACDIIEGQRVYGYSVSPRFNMESRRVVDVIFQRPSPPLMQGWGHTDYSCQDGWMYWSEAIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4G7</accession>
    <name>A0A8G1R4G7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin synthesis regulation, resistance to congo red-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_488295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
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                <person name="Lyhne E.K."/>
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                <person name="Mortensen U.H."/>
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                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516524.1">
        <property type="nucleotide sequence ID" value="XM_025655156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4Z9"/>
    <dbReference type="GeneID" id="37158558"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="224" mass="24936" checksum="C48308BE94625A2F" modified="2022-01-19" version="1">MALHRSGSYLSLSFCSQFLSVHFCLSSFCHVPFPLLFLFSITTYISLLFFFLLLAPFPFFLLPPNFLISGDVSISFSKAFSILLPAISTECSHFHTISYCIPLVSFVELSLQLHDPSKFKYLATSCQKVASMVPTARGGSRVLSVIVNLSPSHFFWHILVSLGVCVCVCVCVRPQCVSITEIHIALYGSKIKAELRKPTDTHSCCYSRKLGCLIQLVVLIHEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R508</accession>
    <name>A0A8G1R508_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_417040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517605.1">
        <property type="nucleotide sequence ID" value="XM_025657756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R508"/>
    <dbReference type="GeneID" id="37161158"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF49">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="66"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH59683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="508" mass="55061" checksum="D85DEC4DD8B67524" modified="2022-01-19" version="1">MARINDVNQMEKQLPQSESKPGQQNDMHTRANNRETPLLDPDFTISFGKDDPDDPRNFGNWHKVYITCQLSMLTFVAALGSSILSPGQSDVAEYTNISSEVAVLATSMYILGWAVGPTLWGPISEVYGRKWGMLPALFCLGLFSIGTAVSQNAASIFITRFIGGIFGSAPISNANAALSDIYAPKERGIAVAFMMLCITGGPSVGPLIGSAVVSNSKLGWRWTMYIEAICCFALFALATLTLSETYSPVLLKDKAQKLRKKTGENRYWHPHEHESINLENAVTKHFLRPLRMLTTESIMACVAAYASFSYSLIYLCLQVYPIVFEEERGYSPVIASLPFLGILVGTACAVGITFAYRTRYAKAVMENGGKAVPEARLPPLVLGVIFLPTGLFWLGWTAAPKFSWVLPTVGGVFVGAGHNIIFQQCINYLIDTYGPYAASAISANTMLRSLLAAGLPLAAKPMFHNLGVGPAASLMGGIACLALPIPFVFMKYGRTLRAKSKFAPASSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R522</accession>
    <name>A0A8G1R522_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_447502</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517541.1">
        <property type="nucleotide sequence ID" value="XM_025659737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R522"/>
    <dbReference type="GeneID" id="37163139"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="171"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="315"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="419"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="610"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="615"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="655"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="676"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH59619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="787" mass="89359" checksum="3C0A3ED4280F82EC" modified="2022-01-19" version="1">MPKSNRPATSGYARLAQEEEDRANDLYDYSDDDDLHAPNTISQSAPRYAPISSRAQMQAAGLSTPPEHRRRLSGHYRRGRRNSGVDIKAINARLERWAEEIASKFKINRVKGKTFEEEKLEIYHSVFQAPDGVRPISAEALESDEIEGAARRARDEFEEVVESVRIAIEMGVHPRMISQGSSGSYFARNAEGKVVGVFKPKDEEPYASRNPKWTKWIHRNLFPCFFGRACLIPNLSYVSEAAAYVLDSRLHTNLVPYTDIVWLSSKSFFYDFWDRRKAWMGKRPLPPKAGSFQVFLKGYKDANLFLRDHPWPDQTNTGFRAEDAPKRKKRPWSEACRPSGVHSDDEDEEEYEDGQARTPSPREESRERRFYWTEGLKQSFREELEKLVILDYIMRNTDRGLDNWMIKIDWKTEEVSIVADPPKPNGVQTQEDDEDMPPARPVSVNSNGTSAAQHPYRRREAMVAVSRTGTPLNATDPQVTVQIGAIDNSLSWPWKHPDAWRSFPFGWLFLPVSLIGQPFSQKTRDHFLPLLTSTAWWSGTQMALRRVFSQDSDFKESMFARQIAVMKGQAWNVVETLKHPDHGPLELTRRTRVCVWDDLVDVPVAIPLRGPSTDAQKRKVKSYEHYDKHASYDPDNEEMDIGAAMSFGTGPDVDLLGLSSPPNELPNPNRFELSRGRGSSSGHARAQSGSPATMGDYRFGRDSIDELSQGQGLDRSWATLPPRPGHRHQKHSSVSNARGQAHLIWSSDDLEGDLGYAAAEGMEGNQRKVIVERLEAVKSKNPVFTWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R524</accession>
    <name>A0A8G1R524_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_415378</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="9"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518158.1">
        <property type="nucleotide sequence ID" value="XM_025657686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R524"/>
    <dbReference type="GeneID" id="37161088"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF12">
        <property type="entry name" value="L-ARABINITOL 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="41"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="192"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH60236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="386" mass="41363" checksum="52A5D953E4DEB1CD" modified="2022-01-19" version="1">MATATVLEKANIGVFTNTKHDLWVADAKPTLEEVKNGQGLQPGEVTIEVRSTGICGSDVHFWHAGCIGPMIVTGDHILGHESAGQVVAVAPDVTSLKPGDRVAVEPNIICNACEPCLTGRYNGCENVQFLSTPPVDGLLRRYVNHPAIWCHKIGDMSYEDGALLEPLSVSLAGIERSGLRLGDPCLVTGAGPIGLITLLSARAAGASPIVITDIDEGRLEFAKSLVPDVRTYKVQTGLSAEQNAEGIINVFNDGQSSGPGALRPRIAMECTGVESSVASAIWSVKFGGKVFVIGVGKNEMTVPFMRLSTWEIDLQYQYRYCNTWPRAIRLVRNGVIDLKKLVTHRFLLEDAIKAFETAANPKTGAIKVQIMSSEDDVKAASAGQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R576</accession>
    <name>A0A8G1R576_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18 19">Pyruvate carboxylase</fullName>
            <ecNumber evidence="6 19">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">BO85DRAFT_421783</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 19">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 19">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="6 19"/>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514932.1">
        <property type="nucleotide sequence ID" value="XM_025657944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R576"/>
    <dbReference type="GeneID" id="37161346"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.600.10:FF:000002">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 19 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 19" id="KW-0092">Biotin</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 19 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 29" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="27">
        <location>
            <begin position="40"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="26">
        <location>
            <begin position="162"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="28">
        <location>
            <begin position="578"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="25">
        <location>
            <begin position="1115"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="20">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="659"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="22">
        <location>
            <position position="755"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="785"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="787"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="920"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="23">
        <location>
            <position position="755"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-biotinyllysine" evidence="23">
        <location>
            <position position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="RAH57010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1192" mass="130926" checksum="E6422E03424F9B93" modified="2022-01-19" version="1">MAAPRQPEEAVDDTEFIDDHHDQHRDSVHTRLRANSAIMQFQKILVANRGEIPIRIFRTAHELSLQTVAVYSHEDRLSMHRQKADEAYMIGKRGQYTPVGAYLAIDEIVKIALEHGVHLIHPGYGFLSENAEFARKVEQNGMVFVGPTPQTIESLGDKVSARQLAIRCDVPVVPGTPGPVERYEEVKAFTDTYGFPIIIKAAFGGGGRGMRVVRDQAELRDSFERATSEARSAFGNGTVFVERFLDRPKHIEVQLLGDNHGNVVHLFERDCSVQRRHQKVVEIAPAKDLPADVRDRILADAVKLAKSVNYRNAGTAEFLVDQQNRYYFIEINPRIQVEHTITEEITGIDIVAAQIQIAAGATLEQLGLTQDRISTRGFAIQCRITTEDPSKGFSPDTGKIEVYRSAGGNGVRLDGGNGFAGAIITPHYDSMLVKCTCRGSTYEIARRKVVRALVEFRIRGVKTNIPFLTSLLSHPVFVDGTCWTTFIDDTPELFALVGSQNRAQKLLAYLGDVAVNGSSIKGQIGEPKLKGDIIKPILHDAAGKPLDVSVPATKGWKQILDSEGPEAFARAVRANKGCLIMDTTWRDAHQSLLATRVRTIDLLNIAHETSHALANAYSLECWGGATFDVAMRFLYEDPWDRLRKLRKAVPNIPFQMLLRGANGVAYSSLPDNAIYHFCKQAKKCGVDIFRVFDALNDVDQLEVGIKAVHAAEGVVEATICYSGDMLNPSKKYNLPYYLDLVDKVVQFKPHVLGIKDMAGVLKPQAARLLIGSIRERYPDLPIHVHTHDSAGTGVASMIACAQAGADAVDAATDSLSGMTSQPSIGAILASLEGTEHDPGLNSSQVRALDTYWAQLRLLYSPFEAGLTGPDPEVYEHEIPGGQLTNLIFQASQLGLGQQWAETKKAYESANDLLGDVVKVTPTSKVVGDLAQFMVSNKLTAEDVIARAGELDFPGSVLEFLEGLMGQPYGGFPEPLRSRALRDRRKLDKRPGLYLEPLDLAKIKAQIRENYGAATEYDVASYAMYPKVFEDYKKFVAKFGDLSVLPTRYFLAKPEIGEEFHVELEKGKVLILKLLAIGPLSEQTGQREVFYEVNGEVRQVSVDDKKASVENTARPKAELGDSSQVGAPMSGVVVEIRVHDGLEVKKGDPIAVLSAMKMEMVISAPHSGKVSSLLVKEGDSVDGQDLVCKIVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5Q6</accession>
    <name>A0A8G1R5Q6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_280741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516646.1">
        <property type="nucleotide sequence ID" value="XM_025655194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5Q6"/>
    <dbReference type="GeneID" id="37158596"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000045">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="185"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH58724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="355" mass="39002" checksum="E3C33C559B6371CF" modified="2022-01-19" version="1">MSNPSSLPPFPSSVPTAPLLRLSLSKLQAHDATETHNLLQACKDIGFFYLDLRDADEGIALLTNADKLFPIGERLFDLPLDEKKKYDLASQNSYYGYKAQGAMIADRQGNLDGNEFYNVSKDDILNLITPPLPSPQILQESRPLLSSFIQTSHNIVTLLLSILSTSLSLPSSSTLPNLHRLSAPSGDQIRFIKAPPTTTTTTQNPTLGEHTDFGSVTILFNRLGGLQVLPPGADAEWTYVRPLPGHAIINLGDAMVKFTNGLFRSNIHRVVAPPGQQAGFTRYSLVYFARPEDEVSLRRLESDRIPALGEGVVEEEISSKDWVIRRALGRRVDLGRPVDYEKAAGTEGVSRRLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R641</accession>
    <name>A0A8G1R641_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_458139</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516856.1">
        <property type="nucleotide sequence ID" value="XM_025661562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R641"/>
    <dbReference type="GeneID" id="37164964"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH58934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="576" mass="65211" checksum="C689A3FDF47763CC" modified="2022-01-19" version="1">MPIEYRAAEVIVVGTGIGGLAATKTYLELSPQTDIVLLEKRPTIGGVWSEENCYEGLKTNNLGGTYEFTDFPMGAKYGITENGHIPGHVLHRYLNDFADHFDIRRRIHFEIQVLEVEKLDQGWRLFTTTKDPAQSVIYSCQKLIMSTGLSSTANPINIRGVGEFKRPVINHVQLREEGARIAQDPNIKSVTVVGASKTGYDVVHLMASNGKKVDWVIRESGGGAVWMASPWAKFAGAKTKLEFLVTMRFFTWFSPCIFGDFDGFSWIRRALHQTRLGRYIVHKFWEGIRTDIIDLNGYRKEECLEHLEPLESLFWSARVGILNYPSDIHDYLRTGQVKIIRKDIDHLSGPGIVNFADGTGVQTDALVAITGWKLAPSVKYRPEGLDASLGIPSSNLSAEEEKLWNILDTKADQEILSRFPYLRNPPRGIPYKQDVSPFRLYRGIAPPSLASKGDNSIAYVKMVHSTSNVIIAECQALWTFAYLNGRIAIDREDVYHQTALLSRYGKHRYPCGFSAWYPEFVYDAVPYADMLLSDLGINQKRKSTLRKEIFEGYTIHDYRGINQEWKEAQKIRTKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R644</accession>
    <name>A0A8G1R644_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_467618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517910.1">
        <property type="nucleotide sequence ID" value="XM_025662198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R644"/>
    <dbReference type="GeneID" id="37165600"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="56094" checksum="7C5C11E675A8DB68" modified="2022-01-19" version="1">MPGALPLLHRQISLSAALDDDDNVLQELSYPQRRVDFYTCRVEEVKDWISGSFNVCIPVVIDGQDGRTSKKVLMRFPLPYRVGESQQPGNSDEKIRCEAATYIWTRQNCPSISIPQLWGFAFAQGPCFTAIQHTSIFSRLKWYLHRVLSPLFGLKTGYLLLDHVGSSDAVMLSESWDRLRHDRKRRANLFRGLSQIILSLAQFPFDRIGSLTIDNHGIVKLTNRPITLRLHHLENESVPTNMDRDLVYSTNDSYYMDLLSYHDSRLRHVPNSIRDKADGEAQLSTLTIMRALLPHFSCRKHRRGPFIMTLTDLHQSNLFVDSDWNIKSLVDLEWTCSRPVEMLHPPYWLTSRGVDQLYEGEHLDAFSEIHAEFMEVFDQEEQNRSQAGKKILGLASIMRRGWATGSFWYFHALETPKGLYNIFLDHIQPRYSKLDDAGMVEFERTVSPYWTPDIQTFLDGKLKEKEIYEGHLRDAFSVAQEEHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R651</accession>
    <name>A0A8G1R651_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1715 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_178574</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518728.1">
        <property type="nucleotide sequence ID" value="XM_025654336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R651"/>
    <dbReference type="GeneID" id="37157738"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="3">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH60806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="196" mass="21338" checksum="E7BC6D996906188D" modified="2022-01-19" version="1">MENNNLLESLLDLEEEFYQEGYDLGAADGAQAGYTEGSVFAVEKGFEKFLELGRLYGKALVWSQRLADSQLSGKPESNDQINGALESDHKQEEPSLLDPAICKEMSSLSSSSRLAKNIEILLELVDPASLPMVNTEEAVNDVDERMKGAAVKAKLVQRAVGEREDNSDIHPDAKDLPVSGDGTGSIEDISSLNIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R683</accession>
    <name>A0A8G1R683_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_456554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="RAH60851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518773.1">
        <property type="nucleotide sequence ID" value="XM_025661454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R683"/>
    <dbReference type="GeneID" id="37164856"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17242">
        <property type="entry name" value="DUF5315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="255" mass="27230" checksum="082752BB45010200" modified="2022-01-19" version="1">MKLEKKISAQRLPPPVLFQGPPSHNASNLSLPPPVSAVPTTGASPRPPLQRNRSSRAGTLEAPGSLSPFLTRKQSKGEVDGSEAIWQEMQSALSEVELSAATGEHVFGEKHSEALEDLRTKQLKLAQAWARSEAGDEVVETKGAAAAAAAAATAKSNASLRPASRSTAGPGDSANPEDGSSRNLDEETEKDILLARERREANDRYFDRVNNGVLDVVAKLEEVAQAMRAVERESKDIWSDTDSMSTTTQTTTDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6S9</accession>
    <name>A0A8G1R6S9_9EURO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_486905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517231.1">
        <property type="nucleotide sequence ID" value="XM_025663417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6S9"/>
    <dbReference type="GeneID" id="37166819"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="302" mass="35381" checksum="5F93FE926A1BBB12" modified="2022-01-19" version="1">MQTDQPPEMPPNPKDESRTLKSLRKIMEKLEGRNVLNFISPSFCDSNNIVLLPLDLEAKHHGKGKSSTTPLLFEPLPIEALHTYPIDPHPYTTIDKREDSCYTIKDYETIKKDSCESYPPFRLKEIAIKLERWIHLAPRTHRYYAVPATLTHIGIWYPSITTDKLYARTSNIYDKLGQYLYTVNRFFECIDDKYPYIVMITQHWCQERCPEDSMMRFELLGILQTMRTRLEQDEIDSEGMVPVLMVSFMIPSHARILQAHMHNGKLVVAHSRIYSFETMREAPMDLFTRWLLSTPVGFFKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6V7</accession>
    <name>A0A8G1R6V7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Enolase N-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_517383</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mandelate racemase/muconate lactonizing enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519103.1">
        <property type="nucleotide sequence ID" value="XM_025664904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6V7"/>
    <dbReference type="GeneID" id="37168306"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000009">
        <property type="entry name" value="Hydrophobic dipeptide epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF2">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme N-terminal" evidence="6">
        <location>
            <begin position="36"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="185" mass="19807" checksum="CE689B40603B110A" modified="2022-01-19" version="1">MTDLKISRIDVFQVDLPYSHGTYHLSGNRAITRFDATFVRITTNTGLEGWGESTPFDNYIASHAGGVRAAIAEIAPKLIGLDPRRVDRLNDAMDAALLGNEPAKSAIDIACWDIFGKSVGLPVCELLGGRTETKLPVLESIPVADPEGTRKHVSDARAMGFTGFSVKIGSDPVTNAARVEAALID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R729</accession>
    <name>A0A8G1R729_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_476072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518621.1">
        <property type="nucleotide sequence ID" value="XM_025662756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R729"/>
    <dbReference type="GeneID" id="37166158"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034361366" evidence="2">
        <location>
            <begin position="17"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="144" mass="15154" checksum="5BD91CA3D9F6C155" modified="2022-01-19" version="1">MKYIFTTLLLVSATLALPTDFSSQESTTAATQQEGIGANPVGLLDDTLSSAKRGNQVARQDPDDFDPTSDGSYKRASQDAQETPAEYFPPLKGIIAKGPGGIGGILGGRPRKPNTRRNNQDAQEATAKDFEGPFGPGLPNGVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7Q4</accession>
    <name>A0A8G1R7Q4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sas10 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_414412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
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        <property type="protein sequence ID" value="RAH61059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="37161049"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="578"/>
            <end position="652"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
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            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="589"/>
            <end position="618"/>
        </location>
    </feature>
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            <begin position="15"/>
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        </location>
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            <begin position="60"/>
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        </location>
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        </location>
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        </location>
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        </location>
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            <begin position="518"/>
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        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="652" mass="72712" checksum="E1E69BE99903F587" modified="2022-01-19" version="1">MGKKRKAGGRPAAPKADKHGPSKFHIEERFDDSEDEFQTGRDQILLEEAPEAKRRRRVAEEEELLQASDEEIMGYDDEDDEDDLDIDDEEDFDEGDDYDEDDMDGVQSKSKSKRGGSPGSEDDEEGIAAWGSSKKDLYSADQIETEADALEEEEEAKRLQQKHLQAINEEDFGFDESEWVESGKDQKDAEDGGEVTEVLPQLEITEDMSEEEKLKILKSRYPEFEPLAKDFADLQSTHQALAKAAQSFNANDDSENAPESAPVTVVKFRALSAYLGTIGMYFMLLTSSTDDSGKPAPLSPAQLRAHPIMGSLVKFRKLWETVKNLSEPEPEASEAEDDSEVDEIMADAPTPKQKSKKGEEQTSKKNKKKAEKVSKAQRAAEAAQAEAEARRAERLRQTEANLADLSKLVSGSSKKRAAQKTKSTKEADDSDFGDEDALTAKEAEEKAKQKRSLRFYTSQLAQKANKRNAAGRDAGGDADLPYRERLRDRQARLNAEAERRGKQKLKDSEQLGGDSDEEDHRVAKQLRGDEGSDDDDYYDMVAARGKQRKDDKKARAEAYAAAAREGGHVEIQEEVGPDGKRAITYQIEKNKGLAPKRSKDSRNPRVKKRKRFEEKKKKLGSIRQVYKGGEGRGGYGGELTGIKKNVVKSVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7R6</accession>
    <name>A0A8G1R7R6_9EURO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_415284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH60181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="435" mass="51842" checksum="D55F326BFD1C4AE6" modified="2022-01-19" version="1">MSVPTLESIPVELHICILDTIPDIHSVWSLLRASPAYYGAFLLVKQSFLRRLLQKHHAGLVDTVDAIAAIRSKGLYASDPSNKRKIVSFLDSRPHNHRTTRPEASLSLLPDEPADVQETMQLIHLHNQAIFFLEDYCRTARRPGWIDEAKWEKEFLPLVLTETEKRRIFRAFYRLQIYGNIFGSIERNVDSEFTLEDNDWTDKQEVFTGGEMWRLFFSHMAPWEVEEFGCLWEHCCYRFESILREVSDSLMQTGFTWFHELPKDEQPPEGCWYSDCDDFVYPENKRENLASKGPAFLSRVLRQKQFRDRRDLVLVNVRSIRFHFFDFGFWPRPSATNDLHLLYPANRFNFGTDRNGLREFLKTFPPFQRPNIAWDRIWLREVYESPEVLFDMYEYGAENRQRRWQYAMWDDTRLTEWEIPIFEDNFPIWDSTLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7S5</accession>
    <name>A0A8G1R7S5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_435877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Aspergillus</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="37161954"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="505"/>
        </location>
    </feature>
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        <location>
            <begin position="240"/>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="485"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="56985" checksum="DD6601ED4ACD6B5C" modified="2022-01-19" version="1">MGQKNYKRLYYNLLRSQENDAQVQEIPITEYPQPEISCYTTPIATVVIGQTHFKIAEYHLRPYSSLSHNSSELHISDINEDIGHTFIHFLSTGCYETLKPTDLGPENCPWAREFERSVYAYHAARRYSIFGLEEHAKRYMLTFSEEVSTRQLLKTVSKVYSELPGHDSWFESFIRDKLAAAFEKDEFSFRYRVVRDGLGSDDDFNRFLMYTTLEIYADKLTSLRETAPNGHHQTNGHAEIPSEEKGPAEEKQSTTESPDDKDESSPRYSNEPLSADDTPTVVNAVNSRPQSPIPPSTAFLASPAQNGYNWASSCSDSPPREFPAFAPSPPLIRRETVDWADPDPEPEREPSFRPETEPPTTDQKPDQELESEQTPKPEPEQKPELEIEQRPESVLEQEPEPVPEPKPEQKPEAQPQTQPPLQPLPPPDLKRKTEPEPVIKTEPELKSVPLPKPAPGNQAAPAEQPAQPKKKNKPNSHRRKKKNAQMHAAAAQQAGPQANGSAAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8B2</accession>
    <name>A0A8G1R8B2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7514 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_476259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517517.1">
        <property type="nucleotide sequence ID" value="XM_025662768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8B2"/>
    <dbReference type="GeneID" id="37166170"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055936">
        <property type="entry name" value="DUF7514"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611:SF1">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24355">
        <property type="entry name" value="DUF7514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7514" evidence="2">
        <location>
            <begin position="251"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH59595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="656" mass="73372" checksum="5E37E06DFAC5BEE4" modified="2022-01-19" version="1">MAYNSFPNSPSYSQFGSMNHANPTENGASSYTPPYPAQYGPEQVNMPQPQVPPTSASPTGYYPKPPYEPAPWQQQQHQQQPPPPPPPPGRINEAVNSAFRQADSPAYLSPEVVSQITATVIQQLKATGLDNLQNDQQPSPPPPPPQWSHPATAAMYGEPSHSPRPQNTPPPPPKIPQGNPEYQPPVPPVHPSSPHLYPGPSMGQPGERRGSPTSQSQVSDHHQSMESRPKPPSREATVTEMTTLDKVWGKFFEDGKPTEKLSMLLCGIAVHLIENYPPENTLVVVPEKMKQFYADTSVPSDPYPWEDIFDDRTSQISRLLRRLEVEHHLVQNKLHERPDIPGLTPRGFARWATLMIQAHPEKEYERFQKALLNMPINNPDNRSERLPKEFSRRLFPDAPDLSLREEIDQKIMEFCNVDLPPITEDELKKVAAQRHKKSAHKASVSSVDSTPSMGERERQPYYSTSSSAIVDDEDKEVPSRPIERERKPYTAHPGGGKVYEDKAPSHRHANSMSAGSGSKDGPIEIGPRMSETHLHTGTSRPTTTFGRSRSPSRGAHTGGDYRHSESDLLGHGSGSRYGGLSDNDYYYPSTTSALPGDIDDSRKYHNLSPDHGDRRLYDALRNRDSEREKLKRSSWGGDEDYYRAATGYDYKPYGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8M3</accession>
    <name>A0A8G1R8M3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_444942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519431.1">
        <property type="nucleotide sequence ID" value="XM_025659145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8M3"/>
    <dbReference type="GeneID" id="37162547"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH61509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="54" mass="6636" checksum="3985FC6C5251B48B" modified="2022-01-19" version="1">MSLPMKHLYTLLAWPMHTKCCKTDRVLYDTCVLLDLQKRFWKRMEESQREAVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R929</accession>
    <name>A0A8G1R929_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_436119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518386.1">
        <property type="nucleotide sequence ID" value="XM_025658561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R929"/>
    <dbReference type="GeneID" id="37161963"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="117" mass="12746" checksum="E6C86D1CFE9FE420" modified="2022-01-19" version="1">MSRVGGICICESSVPLSSSSTTLRARARARTQPYETAGGWVGGWGGCGLNRYRSHVSLQVSENRNALHGLMCCTHCLTSMEQKTAGKVDDDTHHKNAKNISHTSLSMSQRAKRKLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9P8</accession>
    <name>A0A8G1R9P8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor Pcc1</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BO85DRAFT_330830</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
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            <taxon>Eurotiales</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025655441.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="37158843"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000011">
        <property type="entry name" value="Transcription factor Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="104" mass="11427" checksum="5F0F84E2CCC72823" modified="2022-01-19" version="1" fragment="single">MASNGIPSEFPYTLTISLPLPTNRLASAALRTLEVDTELSPFVKRSFALTTPMKEQTADEEAKTVLETTYCATTNRMLRVSVNGFMENLAVVLGVMEELDVDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9U1</accession>
    <name>A0A8G1R9U1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_475350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519153.1">
        <property type="nucleotide sequence ID" value="XM_025662716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9U1"/>
    <dbReference type="GeneID" id="37166118"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="53" mass="6102" checksum="F7018BA6DC464A13" modified="2022-01-19" version="1">MMGFRAASLSETTLPVWCVSFRPQTLFRLDLSLNLFYSTFILLFLPLLDCLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAQ6</accession>
    <name>A0A8G1RAQ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_435317</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518912.1">
        <property type="nucleotide sequence ID" value="XM_025658516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAQ6"/>
    <dbReference type="GeneID" id="37161918"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000006">
        <property type="entry name" value="Nuclear GTP-binding protein NUG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000844">
        <property type="entry name" value="Nuclear GTP-binding protein NUG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="192"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="70"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH60990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="540" mass="59742" checksum="E15D4DCA25BE81E7" modified="2022-01-19" version="1">MVKLGKNSKRVPVRLRHKIEKASAAKQRKQRKLAKKNPEWRSKIKKDPGIPNLFPHKDKILHEIEEKRRLKAEEQQRIRDEARARRQAQKEGGAEEDPVDANVMIDEDDLIDDDDMDEDVGDSSNPMAALLASARARAAEYEEEHSDDEDDEMDEDDSDDEDMDEMDQDEEGGASLDVSAPITQSTSKESSRRAFDKVFKQVIDNADVVLYVLDARDPEGTRSKEVEREIMSADGGNKRLILILNKIDLVPPPVLKNWLIHLRRYFPTLPLKASNGSGNAHSFDHKQLTVKGTSETLFHALKSYAHNKQMKRSISVGVIGYPNVGKSSVINALTARLNKGSSNACPTGAEAGVTTSLRSVKLDSKLKLIDSPGIVFPNSSDKASKKKKKQEEHARLILLNAVPPKQIEDPVPAVSLLLKRLSTSDDLISKLLQLYNIPPLIPTGGDQTHDFLVHVARKRGRLGKGGVPNIEAAAMTVITDWRDGRIQGWVNAPVLPVVTTAEGAAAPAEGVDTKQIVTEWAAEFKIEGLWGNGEDDEMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAY5</accession>
    <name>A0A8G1RAY5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNase3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_361093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520460.1">
        <property type="nucleotide sequence ID" value="XM_025655578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAY5"/>
    <dbReference type="GeneID" id="37158980"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="144"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="372" mass="41321" checksum="0F82D0D3D8A71087" modified="2022-01-19" version="1">MCSKRKSVFSLPSNTEKKKAKVNIYFRVPRLALTLPKYDDDLQLAKESIPSTHSPQSKENNVVLLRTLLQDIIQSQGISQSRGCRTDADILTAATELDAALQRAAGAITSTTKCSQDATLPLETSEANMESCLPSLPPILDDVLERAVFTHPGVSSNIGATYDRLEVLGDAYIELISTKLIWDTFQDIPSGRISQIRERLVKNETLSDYASKYGLDSRVSVPPDYQKQPKRWLKTKADIFEAYVAAVVLSDTSNGYRVAEQWLRQLWSPELEKLGQPKSSLHAKEALAKKIMGKGIKLNYIDERPPAQRGRGLQTYFIGVYLTGWGWNHKHLGSGQGSNKAIAGNEAAEQALSNEPLIEKIMEIKKAHLAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RBZ7</accession>
    <name>A0A8G1RBZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gibberellin 20-oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_466019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520184.1">
        <property type="nucleotide sequence ID" value="XM_025662104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RBZ7"/>
    <dbReference type="GeneID" id="37165506"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="181"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH62262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="338" mass="38675" checksum="EBC049F3E2AD79C1" modified="2022-01-19" version="1">MAAGTVVTLDMAKFFLGSEEERAQFSRDLLQCFASQGFVKLINHGVPNAAIDKAFEWNRSFFELPQDIKKKYPHPPCANPNRGWVSLGQEKSSAIKDFEKGVCKEHKEVFDVKESFDIGNPEDPMYDNIWPDESEAPGFRSFFEIFYELLHVAHLNILKALEMALSTKDQPFEVIKHCMPNVSEMRLNYYPAVDIRDLRSGHMSRISEHTDFGTVTLLFQDSVGGLEVEDQSNLGTYFPVECENKHVMLVNIGDSLQRLTNDYLTSVSHRVTLPISAREREEGQLKERMSVTYFAKVARDNSIYPFGQFVSETNPAKYPHMTAYEWNQIKLEKIYGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC79</accession>
    <name>A0A8G1RC79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_445805</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520304.1">
        <property type="nucleotide sequence ID" value="XM_025659358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC79"/>
    <dbReference type="GeneID" id="37162760"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH62382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="517" mass="58622" checksum="33A892CDFCED2E2F" modified="2022-01-19" version="1">MTNIHPESPEDFEFIETPPASCTTPADDCGVRTTSYPAIKNAPVPADSQGSDSFSNTLLFALLILVPWYLARQIGGGFYTTIFFAIFTTVPILMGFWSIASSISPRKNEKAKYAGRPVEYYLNFHSEHDRTAYRGKSKIPMEVFYEKYFNGEVDFKCDALEALEFRHDWANFRFTMGLYKHFLFGFIPEMLMHTRSQDEEQVRDHYDRGDDFYAWFLGPRMIYTSGIISDPNKEETLEELQDNKLAVVCEKIGVKPGDTVLDLGCGWGTLAKYASVHYGAQVTGITLGRNQTAWGNKGLRNAGVDESQSRILCLDYRDAPRVDGGYKKITCLEMAEHVGVRHFTSFLSQVYDMLDDDGVFFLQIAGLRKSWQYEDLIWGLFMNKYIFPGADASTPLGFVVDRLEAAGFEIKAIDTIGVHYSATLWRWYRNWMGNRDKVEAKYGKRWFRIWEYFLAYSTITSRQGGATCWQLTLVKNINSTHRVEGIPSQYGLSGAREAAITRAGTGAVPKAHVPNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RD75</accession>
    <name>A0A8G1RD75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_515992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521449.1">
        <property type="nucleotide sequence ID" value="XM_025664821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RD75"/>
    <dbReference type="GeneID" id="37168223"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034856946" evidence="2">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="103" mass="11706" checksum="7D12151C088C89C0" modified="2022-01-19" version="1">MKFSNAGLIAFSALLSISSAVPMDKASTNKVRTEEVTGQYDWPQHQARAEELTGQYDWPQHQARAEEVTGQYDWPQHQARAEEVTGQYDWPHNEARSEDSIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDK3</accession>
    <name>A0A8G1RDK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD2</name>
        <name evidence="16" type="ORF">BO85DRAFT_433340</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDK3"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04039">
        <property type="entry name" value="C2_PSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04024">
        <property type="entry name" value="C2A_Synaptotagmin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000445">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000198">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000261">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5035020480" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035020479" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="12">
        <location>
            <begin position="994"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="22"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="239"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="502"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="188"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="363"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="577"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="415"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="849"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="907"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="994"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="994"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="993"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH62744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1075" mass="120059" checksum="10A7584B75F07E56" modified="2022-01-19" version="1">MVRLPLPQRLSSHLSTKSNNPTPGQSRSTSPMRMPEQKPLILKVSVIRGRNLAAKDRGGTSDPYLVVTLGDARQSTPTIPKTLNPEWNVTFEMPVVGVPLLECICWDHDRFGKDYLGEFDIALEDIFQNGDVHQQPKWYTLKSKRKPTKKKDSMVSGEILLKFSLLDASNPNASPTDTYHKFKTMVSSGDEEDDFPQIPSITLDDVDREEETSDETDDPTKPEVVEKRRRRLRLKRLKRKSLAARAYQFSGAGNGVQGIVFMEIVKVTDLPPERNVTRTSFDMDPFVVTSLGRKTLRTPVVRHNLNPVYNEKMVFQVMKHEQSYTIGFTVMDRDKFSGNDFVASASFPVQTLIKSAPEADPETGLYKFVDPSLDPTGAEQGHSSRPSEIKIAISRSPSANSLSTSPKFGTTPRGSSTSLTSQTLQEQSSTLLPPRSIPEIPESSQPSTPTAASFEGDPIGPLESNGLQVYRIQLALKNKERWEDKHFPELFVKAKYMPYRALRQQFWRLMLRQYDADESGRIDKVELTTMLDTLGSTLKESTIDSFFERFSSENEPSDTMDLTFDQAVICLEDTLQALQKDPGSPPKKLSPTPSTASRESDEQSSGDELTMEPRSHNANPQATSVPTLSSDEQPSSTEEDLLPDDLGDERGVEHVIELRECPLCHQPRLSSRSDADIITHIATCASRDWRQVDNLVMGGFVTSSQAQRKWYTKVITKISYGGYKLGANSANILVQDRITGQINEERMSVYVRLGIRLLYKGLKSREMEKKRIRKILKSLSIKQGRKYDDPASASQIRDFINFHQLDMSEVLLPVEKFKTFNEFFYRALKPGARPCSAPEEPGIVVSPADCRAVVFDRLEEATGIWVKGREFSIARLLGDAYPEDVQRFKNGALGIFRLAPQDYHRFHIPVDGVLGEPKTIEGEYYTVNPMAIRSALDVYGENVRVLVPIDSVAHGRVMVVCVGAMMVGSTVITRKAGEKVSRAEELGYFKFGGSTLLLLFEEGAVNFDSDLVDNSKGPLETLIRVGMSVGHSPGVAQYEPDMPKKTEDVSLEEMQAAKRRIEGSLAPPTDAAAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1REA0</accession>
    <name>A0A8G1REA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_495387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521414.1">
        <property type="nucleotide sequence ID" value="XM_025663910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1REA0"/>
    <dbReference type="GeneID" id="37167312"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019268">
        <property type="entry name" value="DUF2278"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10042">
        <property type="entry name" value="DUF2278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH63492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="364" mass="41184" checksum="C9D084082AD8010F" modified="2022-01-19" version="1">MPVKDYGIWKGFPAHYELEDRFEDPKSPHLSLYYHDNNAKMPQFDRDYRHKHKGNPPNKQKPREIPGLFRAAINIKSTGKESRLAYWVNHKLVEHPITEKLSNLDFGFHPIEELTDFDGKGLDFIRGNLFTTQSGRVLPHDIPGTNNDIIDVLEPEVKKAIHHKATIYLFGSMFNTRNGIHNVHMNQGNIPHFVKDDGVFQDGGLIIEYDDHWTGVFLAFASQAAHTDDHNGHAFAKHVVTWADVLPKEIIENSVAIKEALVNPRGRDDRSAKEKEFVTLENLTNHRVALASWRFHNAAGQVQALPHNAALDSRAMKRFEMSNCPLSNNGDTITLLNEEGLRVDGVSYGARQGATEGRPIVFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1REU8</accession>
    <name>A0A8G1REU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_433672</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521042.1">
        <property type="nucleotide sequence ID" value="XM_025658432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1REU8"/>
    <dbReference type="GeneID" id="37161834"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001164">
        <property type="entry name" value="C2H2 finger domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="216"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH63120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1025" mass="112815" checksum="77A56D2C2E5CD681" modified="2022-01-19" version="1">MTMALAAITPLGSGPKRDHTSSTEIGMMTEADALHAALNGPPRKRKRTRKVQTDRKFECTFEGCGKSYSRAEHLYRHQLNHTPKQIYRCDFPDCYRSFVRQDLCIRHRERHTTQGSQLQKRDHFAQTAATGNNLKKPQVSQVMSQVNANHAPTLIPLPSNYSPVQAPSEGPTMTVPAMSASNQHVQMPSPSGSVGMGQGFNYQTLVSHHAVDLSDPTFSRSNSSSNHTLSSPPGPSSTTTFSPPEIQAVPHTALGSHSAGKASPNSGDLSHEVRSHHSVAETTSITHDIDGPSLAHPTTYSGLQLPPGGYPDISMAPATSASTALDNGTLESMSEMMTSGPSVGDAGFDALASCVYPVFGGEAHNRSPFAMADDFTAWLFNDPVTGSPSMGYPAPTNVVPNYLDAVQLQNQFFMSDPAYGSFLSGVIPHHPMSVTSILDPGSPRAIMSEEKRQELLALMSSRFNEAFYAVSAKRKDALMDGDIDDDDHVLSLRMMQMYIGSYWYHFHSQLPILHRPTFEADKAPNLLLLAVMAIGASTLDGIHGSEVTEAAAELANFIAWHLRTELFMDADFRPPAKLWIFQALLLLEVYEKMYSTRALHERAHIHHDTTLTLMRRGSSLIGRSALDSPASFRDDRQARSASGSTMAPDFVAEESWTHWIKAEATRRVAFAAFVLDSTHATMFGHSAKMVAHELRLPLPCDEALWSATSASEVARVQSSLHANGVKPVMFLDGLKKTLNGQRVRTNAFGRTILMAGLLSVSWHMNQRDLQVSSLGGPPALGGRDKWRSALLRAFDNWRRDFDEALGQSPSGPFHSGYRTRHPLDDDNVFESRDVLHGLAHMASHVDIVDCQIFAGANRLMGRSITPRDYKAAREKMVVWATKATARDATFYALKFLSECLLDERRALNEDGELYSGRDDYLLNRPWVLYVAALVVWCYGFALEGPFKSPVKLSTPAAQRQDMQEFLRRMGSVREPSDLEGMQGRNRCLGLLLVLRDGFTNTRWELLAEAANLLTSCIGKLNGAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RFA6</accession>
    <name>A0A8G1RFA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">UEV-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_388095</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521566.1">
        <property type="nucleotide sequence ID" value="XM_025656696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RFA6"/>
    <dbReference type="GeneID" id="37160098"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="14"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="515"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="156"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH63644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="582" mass="63563" checksum="8D707818503721F3" modified="2022-01-19" version="1">MAAVPQRTLNWLYSVLIRDHYDPRQTYQDPNRTYYDVANVLGQYPSLGPRTEVYTYENGFSALLLQLTGTLPVTFRGTVYKFPITLWIPNTYPREPPLVYVTPTQDMAVRVGQHVTLEGRVYHHYLAHWAEAWERSSLIDFLMILREVFAKEPPVKYKQQQPVQPRPPPAQVQAQAPPLPPLPPELDTTINRPSPTHSAPNASPQVTAQVPPPPPPKPGQTPEPQPQSTPSSARYSSPPPLPPLPPKEHDSRRLQMQPQASMGSPMNGPQYPPERSQAPAMASGQYHLPQQPQHGSQSTPAYQAGPAQFRPLNGTPVTRPDDSGRGIPQHNTYYPVQQAPPTAYQRPPPQQVPPQPSPHAGLQQAQQQAPRPKAETQDLLTSPFELELPSFAPTGPAPPIPPNPEKDALLRAVSKTLAQTLQANVAQSETAAQSLISQSHSLHAAIATLQGEVSSLNTLNATLQSNTTTLQQSLMRADGVIADAQSRISSSAPSSSTDPVASGLPPIDEVLVAPTVVGKQLYDLVAEERGIQQAIYALQAALVKGVIGVETWSRHTRGLAREAFLKRALIRKIGKGMGLEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RHY8</accession>
    <name>A0A8G1RHY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_388159</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521592.1">
        <property type="nucleotide sequence ID" value="XM_025656703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RHY8"/>
    <dbReference type="GeneID" id="37160105"/>
    <dbReference type="UniPathway" id="UPA00146">
        <property type="reaction ID" value="UER00577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to D-xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF25">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="16"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH63670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="406" mass="42399" checksum="85CC0DFDFE611DAA" modified="2022-01-19" version="1">MTVNSTETTQALVLHGAKDLRLEPRPLSPPTGSEVQVAIRATGLCGSDLHYYTHGRNGDFVVREPMCLGHESSGIVTAIGPEVTTHAVGDRVALEVGFACRQCALCQQGRYNICPQMKFRSSAKLFPHLDGTLMERTNHPASLCHKLPSHVSYAGGALVEPLAVCLHAIRRSRPPTAEDVSLAQSLGEPAAALIFGAGAIGLLLASALAASQNFSSIVVADIDASRLAIADELGLGLKTTLIPKADPANPAPARDAPAAEQTAWALQNAQRVAGILKESAGVEKTGYARVYDCTGVPACVQAGIYAAGAGGVLVQIGMGHPVQTLPVGAAALREVDILGVFRYDGYAYPAAIELMASGKMDRVEKMVVTHRVALADGDRAFNLSGKGVDEEGRPVVKVVIESGSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGH4</accession>
    <name>A0A8G1VGH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_346158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510188.1">
        <property type="nucleotide sequence ID" value="XM_025655471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGH4"/>
    <dbReference type="GeneID" id="37158873"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF4">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="5">
        <location>
            <begin position="57"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH52266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="185" mass="20443" checksum="C1FDDBE2461A7D3A" modified="2022-01-19" version="1" fragment="single">MSSPVTKTAPPPPPPPPSDPRTKVSPVIRNLRTVPPRSLTVPQPPPPPTTTAPTGPYFLYGTLMDSSMLQDILSLDTDQEIDLRPAYVTGYTCRLWGQYPALIPDDTSSSVVKGVMYRVESVEHGIKLANYETGWYRAEPCEVVYTDGKEPGRENGHVFVFVGEKGELGDGVFDLRVWLGRMGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGM1</accession>
    <name>A0A8G1VGM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_205190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825085">
        <property type="protein sequence ID" value="RAH52414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510336.1">
        <property type="nucleotide sequence ID" value="XM_025654570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGM1"/>
    <dbReference type="GeneID" id="37157972"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034864904" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="10200" checksum="E9524760563593D6" modified="2022-01-19" version="1">MLMFISSIIFLFFIFHTSLISPLARPPPFSRFLDAHVYMNRKTNCECAMQILESDEILYRTSFPLNYYSSHINVSLFCYIFSKASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGS4</accession>
    <name>A0A8G1VGS4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ENTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_453903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825083">
        <property type="protein sequence ID" value="RAH52581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025661156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGS4"/>
    <dbReference type="GeneID" id="37164558"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16992">
        <property type="entry name" value="ENTH_Ent3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH52581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="537" mass="56615" checksum="BE00DC653C4E04AD" modified="2022-01-19" version="1">MDFSNLKEQVSNLTLYDLKAGVRKVQNAVMNYTEMEAKVREATNNEPWGASNTLMHEIASGTHSYQLLNEIMPMIYKRFTDKTSEEWRQIYKALQLLEFLVKNGSERVVDDARSHMSLIRMLRQFHYIDQNGKDQGINVRNRSSELVKLLGDVDLIRSERKKARANRNKFGGFEGGSHIGGGMSSSSSGRYGGFGSDSLSFGGYSGGVYGDGGGFGGNTGDFGDSGRRSNRFEEYDEYDEADASPPRRRGPSPPHASATRQAKQPAAPAPKEPEQDLFDFGEEETVTTSVSASKKPATGNGLDILDTQPADDDDFDDFQSATPAPAPASSAQFAIPPPASTVSTTSSTQFAAPKPVSATQGSNLNGIVGFTSMTPTPTSSTMASPTLSQSSLAQTQKPAQPKPSGFQAATPNYFTSVSTLSNTTQQPAMGHRPNMPSTSSFTSTTPSTPSAANKPAAPKASGDVFGSLWSSASASAGIQKNNTGGNKGPNLASMAKQKASAGIWGAPAASGSPAFNQSSSSGAPKTTGSSGLDDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VGX3</accession>
    <name>A0A8G1VGX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_453841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510668.1">
        <property type="nucleotide sequence ID" value="XM_025661146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VGX3"/>
    <dbReference type="GeneID" id="37164548"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="64"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH52746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="387" mass="42199" checksum="851007A8C00CD7F9" modified="2022-01-19" version="1">MPSLRLPKIPIPRPSYRGYSTSAPSPSSRLNLPIDYRSTPLLHHTASSLSNHPDLPSNPTSKSINFYQAINSALRTALSTSNKVMLFGEDVAFGGVFRCSMDLQTEFGSERVFNTPLTEQGIVGFAIGAAAQGMKPVAEIQFADYVFPAFDQIVNEAAKFRFREGATGVDIGGMVVRMPCGAVGHGALYHSQSPEALFAHVPGVQVVMPRSPSQAKGLLLSSIFESKNPVIFMEPKILYRAAVEHVPSEYYTIPLNTAEVVKPGNDLTIVSYGQPLYLCSAAIEAAERAFGASIELIDLRTIYPWDRPTVLDSVRKTGRAIVVHESMINYGVGAEVAATIQDGAFLRLEAPVKRVAGWSTHTGLMYEKFVIPDVARIYDAIKQTLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VH84</accession>
    <name>A0A8G1VH84_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_472250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511058.1">
        <property type="nucleotide sequence ID" value="XM_025662542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VH84"/>
    <dbReference type="GeneID" id="37165944"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH53136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="345" mass="38686" checksum="72AD4A72824BA1D4" modified="2022-01-19" version="1">MVPALTPFLQYTEKDRRSDAPAFSLALQGPGRLSRTSPYLFHVTLQRVDEVNDHCGELHQVKLPEYTILPQLEHWHFSPYNIHKPGNVQQYYDVIPDRLIPYLQTGERYVLLWPGQQYGSWNWTDKVENSKVVLPGGPFLSFTVKDNENTPIMPTLISGAQECRPTLIAKVECCPQDQVALQDDLVLATLHVTYVPTSGSGGRPFTFNTAGLTVGLWVWRDRWVSLRGFVCGGAWAFVDDPDMQVSPGRDKGFASLRPGETWSEVLQLPLLTDMESNDGGEARAGEGIRCLFKGLRLDWWVWGSREDHLETTVTIPATGSWTVREPGEQPNAFIPAAAPVNLEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHT5</accession>
    <name>A0A8G1VHT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Branched-chain amino acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_428835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511598.1">
        <property type="nucleotide sequence ID" value="XM_025658221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHT5"/>
    <dbReference type="GeneID" id="37161623"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH53676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="371" mass="40890" checksum="1F0A3CD64E1D10F3" modified="2022-01-19" version="1">MYVVSLADGHASLELITSELRSTTSDIVPTSHVECTYSPTTSSWSAPTVINNPNLQINGFAVGLNYGGPYYESLTARRTRDNRILLFRPHDHARHLADAATAVGMTAVPEHIFLECVRKAVAFNTFYVPPPQTDAVLYIRPLLFGPSVPRIRDSPAQYIFCVFVQPGAVYPRTAAQNAIVLSDSGADDVPTAAETQKCSRTETWDEGWKRGLGGTGQLDGRQAERDDYTMKLQLENTRHGSFIKGFTASAFIGVQEEHGRYTLMVPRHPSRSIISDSCVAIAIQLGWKVKVGPISVDDIDTLSEVIATSTWHWLLPIRLIFYPSARQTVVYHAGSHKAGSACRVLRNAIGKIMGGEVSDIWQWCVLVTQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VI56</accession>
    <name>A0A8G1VI56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin depolymerizing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_452489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512031.1">
        <property type="nucleotide sequence ID" value="XM_025660834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VI56"/>
    <dbReference type="GeneID" id="37164236"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF130">
        <property type="entry name" value="SEVERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="3">
        <location>
            <begin position="71"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="3">
        <location>
            <begin position="187"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="3">
        <location>
            <begin position="313"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH54109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="390" mass="44088" checksum="64DB4D24E1FC080B" modified="2022-01-19" version="1">MPPHEGLVHPKEYDIKDSNVELIGSDLDHRVKYNSAATEPAWNNGSIGQEPGLFVWRIENFEVIPWPKERTGEFYNGDSYIVLHSYKVGDKLGHDIFFWLGSKTTQDEAGTAAYKTVELDEFLHGTATQHREIEQEPSEEFLGLFRHISIRSGGVRSGFHHVEPEAPKDILTLLRVFKHPSLGRSIIVHEVEPTWESLDENDVFVLDKGDKIWVWQGKNCSPMEKAKAAQVVNDMTLAKHIDVEVLSQLESRSRVIVDLLGGKEADPSTFQAPRPGRFAKRTDDGGDVRSRKLFRLSDSSGTLTFDLVKDGQRVSKSDLVGNDIFLYDVGSRLWVWQGSGASQREKALWLKVAQHYVRQLQNQLPEAHYIPIAKVVEGYESPAFMRAIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIK1</accession>
    <name>A0A8G1VIK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_441390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512363.1">
        <property type="nucleotide sequence ID" value="XM_025658805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIK1"/>
    <dbReference type="GeneID" id="37162207"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="209" mass="24480" checksum="D298535275FCB278" modified="2022-01-19" version="1">MAHHGQPQPVEPVGSFWNEPICQDYLERIYPGPDDFRGVHHFWPVLLRHYFTLEDNCGSESERCTTHPRPRQHLNTFVVHIASPHLRRRRVIAVEARWFPSDTSPGWENNYDWTHVRETLRAHMLSDWTMRTTVQTTYGIVAVGDRVRFYYMSKNDLEGELRTWNGHPVDAPEADQSPILNIFSLVDQGVIHQLMLRMRQDVLSGCNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ09</accession>
    <name>A0A8G1VJ09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Trimethyllysine dioxygenase</fullName>
            <ecNumber evidence="4">1.14.11.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Epsilon-trimethyllysine 2-oxoglutarate dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">TML hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">TML-alpha-ketoglutarate dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO85DRAFT_378241</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6),N(6),N(6)-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:14181"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58100"/>
            <dbReference type="ChEBI" id="CHEBI:141499"/>
            <dbReference type="EC" id="1.14.11.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.8" evidence="4"/>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512843.1">
        <property type="nucleotide sequence ID" value="XM_025656292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ09"/>
    <dbReference type="GeneID" id="37159694"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044594">
        <property type="term" value="F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050353">
        <property type="term" value="F:trimethyllysine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012776">
        <property type="entry name" value="Trimethyllysine_dOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02410">
        <property type="entry name" value="carnitine_TMLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078:SF57">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="7 20" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisomal multifunctional enzyme type 2-like N-terminal" evidence="19">
        <location>
            <begin position="19"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="16">
        <location>
            <begin position="173"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="18">
        <location>
            <begin position="362"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="17">
        <location>
            <begin position="465"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RAH54921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="743" mass="84282" checksum="E93890B864E3211D" modified="2022-01-19" version="1">MSTPGAGHEFPSQEVSWLKRDALLFAYSIGCKADELHFLYELHPNFAVFPTYPIILPFKLTDQEVTDFYARSGGSPIPGVPKFDYRRVVDGQRKLTILKPLPPTSEGRKFELRSKVIGVYDKGKPGTVIETEQTIVDKETGEIYSRTVSSGFFVGQGNWGGPKGPSNANYAPPEGKQPDAVYVVQTTPETAHLYRLNGDYNPLHATPEPGEKMGFGGAIVHGLFSWNSAAHGVLRELGGSDPKNLKEIQARFASPVIPGDKLITEIWRTGSLQDGYEEIRFVTKNVMVDRGTSTSRAVSSFTPKYVGVTYKSSSVSTRFPSLVRANSSIANAQATPSSSANEDPWPLHLRNQKWESLQLGHEGQASNFGTFWLRDNCQCSKCIHPDTRQRTVDTFAIPDDIRVKDLSYEKDGVKVDWSDGHHAYYPFPWLKSHSNKPVSKLEPKSELHFREIKSYVPGRDTTFPTFFYADIMANDGALCDWLEGIYDWGFAFVQGVPTNPESTEALLKRIAFIRNTHYGGFWDFTADLTFKDTAYTTEFLGAHTDNTYFTDPARLQLFHLLSHTNGDGGASLLVDGFRAASILREESPQDFEVLLSTNHPYHSSGNEDVCVQPAEQAPVLKVHPELQRLYQIRWNNYDRAAKKNWNWEEQVKWYTAARHWDEIIRRKDMEIWTQLEPGTALIFDNWRMLHGRSEFTGKRRMCGGYINNDDFISRYRLLKFGREEVLRNIGNDQWSLDNPNYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ76</accession>
    <name>A0A8G1VJ76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RPEL repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_471649</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH54007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511929.1">
        <property type="nucleotide sequence ID" value="XM_025662489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ76"/>
    <dbReference type="GeneID" id="37165891"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043451">
        <property type="entry name" value="Myocardin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793:SF12">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH54007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="145" mass="16578" checksum="D5636129D2DBB789" modified="2022-01-19" version="1">MDLNTTTTATSIDETPLSASPERRSSLEKHLQRRPDVQDLKDRHILLDTNVAPSLQATRQELARQRTTDALKKHLEHRPEREELVERNILPTTHAAPALQANARELEKHMLADHLDHKIQNRPNPEDLISQGILTEDEDPRFPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJN7</accession>
    <name>A0A8G1VJN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_453583</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510850.1">
        <property type="nucleotide sequence ID" value="XM_025661085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJN7"/>
    <dbReference type="GeneID" id="37164487"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH52928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="477" mass="52341" checksum="B16A08635102AA5C" modified="2022-01-19" version="1">MSGEKNLDHAESVQDVEVAPQVTQESYTGIDLSTREKALVWKQDLRIVPLCAGIYLLCYLDRSNIGNAKILNQDTGNDLLSETHMTSYQYTVALMVFLIAYALFEVPSNYLLKKLKPSRWIGFLMLSWGATTMGLGGSHNFSQVTGIRFLLGATEAGLFPGLVYYLTFWYRNSERSMRVALILASATLAGAFGGAIAYGVGHMNEVRGLSAWRWLFIIEGAPSCASAFLVWFFLPDYPESASWLSPEEKDLAIHRLKEEGSHGAAKAMSWEEAKEILTEWRLYAHYIVYFGISTPFSSLSLFTPAIVSGLGYADLRAQLMTVPPWAAAYVVTTVVAWSADHFNSRGLHSALFAFIGAMGFLASAVLPADAYLHRYGCLVVAASGSFACIPPLLGWLSANIRSTAGTGLAIALNVSFGAPGQIVGVWIYKSDEEKKGYPTGHWTNAALLLMVTVGCILLRLYYGWRNKATKGGERFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJY9</accession>
    <name>A0A8G1VJY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Galactokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_382215</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511135.1">
        <property type="nucleotide sequence ID" value="XM_025656459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJY9"/>
    <dbReference type="GeneID" id="37159861"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000411">
        <property type="term" value="P:positive regulation of transcription by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.340:FF:000003">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000056">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3170:FF:000002">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="4" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="11">
        <location>
            <begin position="42"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="9">
        <location>
            <begin position="142"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="10">
        <location>
            <begin position="409"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH53213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="524" mass="57633" checksum="AA1D261FCDE22D07" modified="2022-01-19" version="1">MATPQELVPQTESIAEVYATDDASVTSVAPHHQSRFNNLVSQFTKVYSHRPDFVARSPGRVNIIGEHIDYNLYDVLPTAVSVDVIIAVKVVPATGSDSVVKIANVNPEKFPTREFVVPRDTDIEIDPKKHEWVNYFKAGLLGALKFLRKQNADGSFVPASMEVLLDGNVPPGGGISSSAAFVCASALAVMKANNHDVSKQDLLDLAVVSERAVGVYSGGMDQAASIFSRRGYLLYTQFFPNFSVQHVPIPKADEEITFLMAQSFVTSNKAETAPRHYNLRVAECTLAAVVLAARNGLTLPKDNSSLGFSLRNFQNEMMRKEGRLGDPLEYQIDSVIQSTLELLTQEEGYTREEIAKLLGITVPELEAKYLSSFPVQAERFLLRQRALHCFTEARRVLDFKACLAKASTLDERRIQYLGQLLNESQASCRTQYECSAPEVDEICDIARRAGTLGSRLTGAGWGGCTVHMLPQSKVEAVTKALKEEYYLKHFPDISEEKLAEAMVISKPSNGSFMVTGAAIAQVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKR1</accession>
    <name>A0A8G1VKR1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7514 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_471616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511885.1">
        <property type="nucleotide sequence ID" value="XM_025662485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKR1"/>
    <dbReference type="GeneID" id="37165887"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055936">
        <property type="entry name" value="DUF7514"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611:SF2">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24355">
        <property type="entry name" value="DUF7514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7514" evidence="2">
        <location>
            <begin position="14"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="539" mass="61606" checksum="1981977EBD9CD103" modified="2022-01-19" version="1">MFSAHDHQGPSYWGVLINADKSPAPLLEQLCLEIARIILISHGSRAKTSFDDYATADLTPERLAAFYRKVGGNYDVLFLQTKPSALSFIYQRLGCFHSIQPTSDPYKPPAIPALQPNGFVRWQTIQLLLDPDEHCRYLQNAVELWDIETPSGEFFPKQIPREAFPDRPDPEMVEWHESVSRRFELDYIKRNILRASPPSFGTYHSHFSNKDIPLTREETSLPPRRRSSTHRPHLVPEEPSPPSRHQRRRSGEYPPPATRRVQSTYFPRAPDVEAPRRAPSPPMWTKSAPKPRGRDRTPAYSRPVSPNTLPGNSASDASSEDSGGAVRRASPSASRHHRHLRPDTPHHSHARRHSHESYARRPERAFSPDDQRRYMHRDMYNASSARPYDSDGPRRARSSRIYAEEPVRPPRTPRPTFRDHVFTDSAAVPVNHEVPVYTHMHPRYMNRNGSYPVRPPPPPDVDMRAGDDGRRSYRGPHVNPNASGFSNSATPERSRYPSGGYRPQRWANPVQPSPARGIPVGMPDMEYPPRSRRSTMYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLL0</accession>
    <name>A0A8G1VLL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Probable beta-glucosidase M</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Beta-D-glucoside glucohydrolase M</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cellobiase M</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Gentiobiase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO85DRAFT_421598</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515618.1">
        <property type="nucleotide sequence ID" value="XM_025657936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLL0"/>
    <dbReference type="GeneID" id="37161338"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF5">
        <property type="entry name" value="BETA-GLUCOSIDASE M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034884018" description="Probable beta-glucosidase M" evidence="19">
        <location>
            <begin position="20"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="20">
        <location>
            <begin position="688"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RAH57696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="765" mass="82213" checksum="FB9C993F2094B2F3" modified="2022-01-19" version="1">MHSISALLSLLGSLALSSAAPSQNITSDTYFYGQSPAVYPSPEGTGTGSWASAYEKAKAFVAQLTDDEKVNLTAGVSSKTGCSGFIAEIPRLNFPGLCVSDASNGLRGTDYVNGWSSGIHVGASWNRTLARDRAKYMGQEFHRKGVNLLLGPVVGPLGRVAEGGRNWEGFSNDPYLTGALVYETVQGVQSSGVGVSTKHYIGNEQETNRNPGTVNGVDVAAVSSNIDDKTIHELYLWPFQDAVLAGSVAIMCSYERINNSYACQNSKTLNGLLKTELGFQGYVITDWGAQHGGIASANAGLDMVMPETTLWGSNLTTAISNGTMEASRLDDMATRIIATWYQLNQDTDFPTPGVGMPATAQSEHQAVVGTSPDEKSTLLESAIEGHVLVKNTKNALPLQTPQLVSVFGYDAKVIDSFDLASTVLGDNALFQNYTLWVGGGSGSNSPAYVIAPLNAIQQQAYEDGTSVLWDVSAQDPEVDPTSDACLVFINSYATEGYDRPALTDDYSDTLVTNVASKCNNTIVIVHNAGIRLVYNWIDHENVTAVVLAHLPGQDTGHALVDILYGRANPSGKLPYTIAKQASDYGSLLHPSEPQTPYGLFPQSDFSEGVYIDYRAFDKDNITPQFEFGFGLSYTTFDYSGLSIEKTNETTSEYPPSAAIQEGGNPRLWDELVTVTAEVQNSGSVDGAEVAQLYVGIPNGPVRQLRGFDKVLLSAGETAQVSFSLNRRDLSTWNVEAQQWQLQSGTYQVYVGRSSRDLPLTGEFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VLL9</accession>
    <name>A0A8G1VLL9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vitamin H transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_459712</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515648.1">
        <property type="nucleotide sequence ID" value="XM_025661669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VLL9"/>
    <dbReference type="GeneID" id="37165071"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000394">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="46"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH57726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="471" mass="51497" checksum="CD2608D1E941C863" modified="2022-01-19" version="1">MDTVDIHEGQLKDASSHEIEDVDAIEVISFTPEEEKALVRKIDMTLLPTVWVMYLLSYLDRTNIGNAKISGMQVDLNLTSNEYSIALVVFFVGYVVFEVPSNLALGRSRPSIFLSTIMILWGALTCVMAVVKDFSHLVVLRVIIGCIESGFAPGVLLVLSSWYKQTEQSRRFGVFISAAVLSGAFGGLIAAGIVDGLEGVHGIRGWRWLFIIEGVITVGCALISLFILPDFPATTRRLSDRERQIAVARLTRENVTASTEDTEHLSSLGACRVACKDFRTWAFVIGYMVIVGSSTLTYFYPTLVKGLFGDASTEKVNFLTVPIYGVAFVATGITSYCGDKFPTWRGLIIAGWLAFSLICSVIVCAVYNFTARYVLLVLMAAGLWSTNGGTLAYASSAFAGMHPQARGVALAMVNALGNLAQIYGSYLFPDKDSPKYIMGFSVISAMLAVGVVVFLVLHIWFRRRLRSGNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMJ6</accession>
    <name>A0A8G1VMJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_470105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513685.1">
        <property type="nucleotide sequence ID" value="XM_025662371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMJ6"/>
    <dbReference type="GeneID" id="37165773"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="524"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH55763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="624" mass="70293" checksum="DCC09A4C422575B9" modified="2022-01-19" version="1">MADDYKFMCPRPRSSKACDACRTRKIRCIPNEKGGGIDACRRCAKLGYTCTVNGSFPSSTANRSNDRVVKASTHHGDDVVSGLFRSQPKAEEDEVMQLRQLHRGVLQGRNLGEDPRTLIDNQSSVGDTVDCNSRSSKISLNMNDAEQLLLQFRQQRAYFPFIEVPEGTTAALMAPSQPFLLLAILTVSLTRKPLLQKRLDERFRRVLSERVIFYGEKSMDYVQGLLVYMAWRPLHIRPLSRQGSQFMQILVTMISDLKLTENMHDQAARDICLGCFSLSSLLSIGFRRRGDDVAYKYLKEAVDAKQRLNQPYDEQFQLSKLHVLFEETVRCHIECGPLKCPITKQRRVEEKMESLRLELQIFERVHGPSTNANIHTAPVRLLLSSLRVHIALLPFRILDPRPSTIPNFEGLVDQGTSCATEIRLFFEYFLCIPPDQYIFFSVRDWCQLILAISAASDICFLSLASMSLIWTDFQIKTRSGILIYLESLSHRMSRLSVAKAGETPDVFFMFKSVLDIVLSTYAPTSGDSSSLAPTSRRGNALEREETGRDVAATSSTPSTRCPMVNGSIRESEFWEAMKQSDLYLEGLASGVNGEDVYTSGVDSLIADCGDWPSIFSEWVNVSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMU0</accession>
    <name>A0A8G1VMU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytoene desaturase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phytoene desaturase (3,4-didehydrolycopene-forming)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_518911</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516983.1">
        <property type="nucleotide sequence ID" value="XM_025665004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMU0"/>
    <dbReference type="GeneID" id="37168406"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016166">
        <property type="term" value="F:phytoene dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000171">
        <property type="entry name" value="zeta-carotene-forming phytoene desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008150">
        <property type="entry name" value="Phytoene_DH_bac_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF1">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00982">
        <property type="entry name" value="PHYTOENE_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="10">
        <location>
            <begin position="14"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH59061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="544" mass="61172" checksum="6622200B07FD4E84" modified="2022-01-19" version="1">MAKKSALVVGAGVGGISTAARLAREGFTVTVLEKHAFVGGRCSIIQRDGYRFDQGPSLLLMREIFSRTFQDLGTSLSSEGVELLKCEPNYCIWFPDNDIVELSSDITRLKEEVIRHEGITGLSKLLDFLKETGQYYNLTLDYIMNRDFPHFLSLLQPNVLRALVAMRPWTTMAGIVEQYFTSTKMKQAWTFASMYMGMSPYQAPGTYSLLQYSETVDGIWYPRGGFQKVLQALADVGRRLGVDYRLRAPVDSVLLAPDQRSAKGVRLSSGEEIHADLVVINADLVYAYNNLLPESGYGRSLQQRHTSCSSISFFWAFDTTFPQLKSHNIFLAERYRESFDSIFVDHSIPDEPSFYLNVPSRIDPTAAPPGKDAVVVLVPVGSLREPGTNDKKHWERIIPDIRDLVIRTIEERTGLRNLRSKLLHETYETPHSWKDKFNLDRGAILGLSHSFFNMLSFRPSLKHPTIDGLYFAGASTHPGTGVPVCLAGSKLVCERILRDTRLEQRIMFATAYIWVTFTLVVVLATACVTLLYPSCLDSFLCLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMV1</accession>
    <name>A0A8G1VMV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_418516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517161.1">
        <property type="nucleotide sequence ID" value="XM_025657819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMV1"/>
    <dbReference type="GeneID" id="37161221"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586:SF21">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE (PLP)-DEPENDENT ASPARTATE AMINOTRANSFERASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="1">
        <location>
            <begin position="20"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="400" mass="44561" checksum="560EECF7E7E12FC3" modified="2022-01-19" version="1">MSFNISQARSRFPALNQEQVFLDNAGGSQVLDTVIESVTSYLSKTNVQLGATYNTSKVSTAAYDHGYEAAAKFINAKPEEICLGVSTTQLLHNLSTALDFQPGDELIVSKLNHEANSAPWDRIARRLGLTVKWWGASDPLNPICDPSGLKQLMSEKTRLVACPHASNITGSITNVKEIAKVVHQAPRALLCVDGVALAPHRQVDVKDLDVDFYAFSWYKVYGPHIAQLYASSRIHDQINPLCHYFKSTETLDLKLNLASANYELTQSIPRVLEYFGSNFSATWDEIATYEEKLQEILLGFLRRNDLVTIHGEPSANKALRVPVISFTVKGIKSQALVEEVEKRSPFGFRSGHMYSHRLLKDIIGLEDVEDGVVRISMLHYNTEQEITSLVELLREIIAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMV5</accession>
    <name>A0A8G1VMV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_368519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517028.1">
        <property type="nucleotide sequence ID" value="XM_025655872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMV5"/>
    <dbReference type="GeneID" id="37159274"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="74" mass="8687" checksum="17BCDA0A1414091F" modified="2022-01-19" version="1" fragment="single">LNYYMKLHHAYYSFIITDHELVAIRRLDKDGNLELLTPISWTVKGTASKPRLTVLLGIWYLGMLAANNQVWYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNJ9</accession>
    <name>A0A8G1VNJ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_394180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516787.1">
        <property type="nucleotide sequence ID" value="XM_025656914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNJ9"/>
    <dbReference type="GeneID" id="37160316"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH58865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34850" checksum="72DD5238A8DFED1F" modified="2022-01-19" version="1">MSHQVTEFLNWDLLRLAWEDLPRETKAFLCSYIRDVKSDDLESHVKHIANAGWDRVPYPCFGMLSFVDFDLSKSPVYDEIISNLTASSVMLDLGCGLGQEIRRLVYDGAPAENIVGLDKDERFIELGFDLFRDMATLDSTFLVDDFFKPSPKLAQLASQIRVINSGYFLHLWDWGGQVSVAKCMIGYLSLQEGDLITGVQFGREDAGLWKVPTLDYAIFLHNPASFASMWHQIGEETGTRWLVWSRSDREGTHEKLAAKGFRLRWYVRYEGRQSQPVPGENFSGNQADQERCKSIQLRENFRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNN1</accession>
    <name>A0A8G1VNN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component RRP45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ribosomal RNA-processing protein 45</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_394321</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516892.1">
        <property type="nucleotide sequence ID" value="XM_025656920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNN1"/>
    <dbReference type="GeneID" id="37160322"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000005">
        <property type="entry name" value="Exosome complex component RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0271">Exosome</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="32"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="12">
        <location>
            <begin position="192"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH58970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="292" mass="32234" checksum="F809807820660E8F" modified="2022-01-19" version="1">MNKEALLSVTERDFILNALREDVRLDGRGFDQLRPLNVSFGEEYGHVKVQLGKTSLIVRISAEVTKPHDDRPFDGLFTIAMELTAMGSPAWDNGRQGDFETYVTNVLDRVVRHSNALDTESLCILKGVSCWSIRADVHVTDYDGNLIDAACIGIMAGLQHFRRQDAVVKDGQVIVYGLDERVPVALNITHKPLSVTFHTFDEGKRVIIDATRKEEQAAEADVVIGINNAGDVCFVSKFSGSPVDAMVFVDKTSVALEKVKEINATIDKALQADLSKRAKIGMAEESRAENDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP31</accession>
    <name>A0A8G1VP31_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_394821</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517134.1">
        <property type="nucleotide sequence ID" value="XM_025656931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP31"/>
    <dbReference type="GeneID" id="37160333"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000034">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000006">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="10">
        <location>
            <begin position="228"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH59212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="495" mass="54368" checksum="4224E269F2279CE0" modified="2022-01-19" version="1">MSSALLSEAARIASQFDYPAAEVQRGVTEYIREIDEGLSKEHTTLSQIPTYVTAVPNGTEKGLYLAVDLGGTNFRVCSIDLHGDTTFSLTQSKIMIPRETMASGTAKDLFLFLARQIESFLRIHHNDHFEAHLRRRNEKNGNCEEDLFDLGFTFSFPVRQLGINKGTLIRWTKGFNIPDAVGQDVCALLQNAIDDLGLPVRVAALVNDTVGTLMARSYTSPGETGTFLGAIFGTGTNGAYVEKLDRITKLQTIEHSEYDKTTGEMIINAEWGSFDNHLSVLPNTIYDQQLDADSNNPGIQMFEKRVSGMFLGEILRRVMLDMQRNESLGFLKTGGASTVSVPKESSLYRQWGIDTSLLSLVEADKTENMEQIKVALKDHLKIERPTTDDCKAIQTVVHAIGKRAARLSAVPLAAVLLSTGKLQKDDLVDIGVDGSLVEFYPNFEGYMRDALREVPEVGEAGNKKIRIGISKDGSGVGAALIALVASKEDARRKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPT3</accession>
    <name>A0A8G1VPT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_447894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH60037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517959.1">
        <property type="nucleotide sequence ID" value="XM_025659806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPT3"/>
    <dbReference type="GeneID" id="37163208"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000007">
        <property type="entry name" value="50S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH60037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="166" mass="18705" checksum="431D8DD935B540FC" modified="2022-01-19" version="1">MSQTVGKTRLAFSRTWHYVDVGSDPRSLGRLASSIALTLMGKNKPVYDPSTDCGDYVVAVGCHDLRVTGKKRFQKKYYTHNTRPGSLRSMTMDKMFEKWGGGEVLRRAVRGMLPKNRLRDKRLARLKTFEGLAHPYKENIVKLNGQSVIGNLPEVKEAFKTAKTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ40</accession>
    <name>A0A8G1VQ40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS alpha-glucoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_446600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519368.1">
        <property type="nucleotide sequence ID" value="XM_025659540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ40"/>
    <dbReference type="GeneID" id="37162942"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF71">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G02650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="63"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH61446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="539" mass="58942" checksum="69551E221287763F" modified="2022-01-19" version="1">MSLEGNRKKSGVPDEIVKQLPSNVEETGAERTNDAEKSLAHTRFEHSLGFWKACQFYRPALLWSCFVNLAVILCGFDGALIGSLVGLTPFVRTYGRLVDGQYAVAPSWLSAFNYASYVGSVPGSLVAGIAYDKYGPRMTLAAASIGSIGSIFFQFFSEGPALLFVGELLNGFITGVYPVLANAYVSEVAPVAARGVLAAVINLSYVIGQLVASGLLKGTSTMDSKWAYKIPFASQWALPVFILSLIYFCPTPPYWLCKKGRPEQARKSIQRLTTSEVDVDAYLAHIEETLRLEESSRTKASILDCFRGTNLRRTIISCQAFNIQALCGNILFINYAVYFFENAGLDTSDAFSMNVGLTCMGFVGTLASYVLISYAGRRTIYLWGSTVIALLLLLVGILAVVPQHNSGPVWAMSALMVICNLVYDMSVGPLCFTVMSEVSAVNLRGVTIALSNVTVVIWSVIFAVAIPYAMDTTGANWGGKLGFLFAGIGVLDTLWCYFFLPETKGRTFEELDFMFQQKLPTRQFSKYQFTETQQVAPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQN5</accession>
    <name>A0A8G1VQN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_181713</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518859.1">
        <property type="nucleotide sequence ID" value="XM_025654352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQN5"/>
    <dbReference type="GeneID" id="37157754"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001704">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000432">
        <property type="entry name" value="zinc finger protein Gfi-1b isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="530"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH60937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="577" mass="64108" checksum="4D34555A23A6E6B3" modified="2022-01-19" version="1">MASHTKKDDFCLECHWEAFHLDGKEAEDVSEAQPVQWNCSDQVHHTPVPPCNGDDECNVEEDCCDVDDCSITCPSVCDGFIECGDAAVCSVSHCDEDHCENTDPVCFDEHCFGTGTNIDGEHSLESLLGLGTPLNLDTTDLLSPTSMPQSQVEQPKTMAQPTGMVPSAPSDAFFNPYAPASHCHSHSHQHFHCHDISKDAHHAANPWLPLQNAVNPADVFHMMCPDLSACHQFHVHEVQNCSEQDKPADDAASNSFTCFHIPHHPHHHHPPNEVKSPAPAQKPTNNWKPCRTHVHRCRTHGHHVHSYSPYSRHSRSSVSSQLSPGETPPPLEGGTSSVLTSPEYTPDTEIYMCRWTSKADGTKLPCGATFADACGLQEHLVACHMATVDGAKGTGYYCCWEGCHRPDEPFSQKSKLQGHFLTHSNYKNFKCSVCGKMFARQATLERHERSHRGEKPYKCTECGKSFTDSSELKTHSRTHTGEKPFKCTYPGCNFQTGDSSNMSSHRLSMYIVDRFMQSILTGLAHGERRHKCHHAGCTKSFTRHDQLKRHLRTTHKEDISLGTPMPDDFGLAFAEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR69</accession>
    <name>A0A8G1VR69_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7770 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_445040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519517.1">
        <property type="nucleotide sequence ID" value="XM_025659170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR69"/>
    <dbReference type="GeneID" id="37162572"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056672">
        <property type="entry name" value="DUF7770"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24968">
        <property type="entry name" value="DUF7770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7770" evidence="1">
        <location>
            <begin position="30"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH61595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="175" mass="19397" checksum="141435B5D5ED55C0" modified="2022-01-19" version="1">MPNLQIIHFIPPSREAIILNSPVHSITAVPHTQTAGTNHWCLYLATSDTTSVCIDCQPSHTVPSTVLHGGSKGFIAISELPYLWAPDAQAQFKLNVPPNLKVKDVYNLLIQNDRHKYEFDSTGVGCRYWVTDQLGLLQHQGLLVDPEEVTAAKTGIVLLWPDQTPLPLDQGAYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR81</accession>
    <name>A0A8G1VR81_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_494158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520716.1">
        <property type="nucleotide sequence ID" value="XM_025663860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR81"/>
    <dbReference type="GeneID" id="37167262"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF230">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="46"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH62794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="440" mass="48119" checksum="8F2E5DB8C3B3BC59" modified="2022-01-19" version="1">MRRSARQDSSVLTEELELRSHTGIYDTEQPADGPGVSQAFPEGGREAWMCLLGSFLLMFPSFGFEAAVGTVQDYISEHQLAEYSIRDVGWITAIFVFLTLFLGVQVGPLFDRYGPRVLLTCGSAASFTSYMLLAECTKYWHFILCLSILGGIASAIVSTVSISVLSHWFHRRRALASGICMGGSSAGGATIPVILRTLFSKYGWTWSIRVIAFIALGCYAAAIILVKGRLPAGSNSKATIDFRAFRSPRLCFLTVAVFSFEFIIFGCAALLPTYVRFAGFPTDVQFYSLTVLNCFGLVGRVLPGFAADKIGRFNILLCLVLLTFIIMATVWLPVGSHDVKTLYTVVAIFGFGSGGWISLAPVCAGQLCRTEEYGRFYGTLYSVASFGVLLTVPVGGDLLQSTTPQILIGFYSAVLLVGLVGLILSRWALLDWKWRWKVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRH9</accession>
    <name>A0A8G1VRH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DEAD box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_482797</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520853.1">
        <property type="nucleotide sequence ID" value="XM_025663125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRH9"/>
    <dbReference type="GeneID" id="37166527"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001366">
        <property type="entry name" value="ATP binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002468">
        <property type="entry name" value="Suppressor of ascus dominance 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZNFX1" evidence="5">
        <location>
            <begin position="121"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="292"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="681"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1031"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH62931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1077" mass="121570" checksum="E64841CDFEA90685" modified="2022-01-19" version="1">MDSGDYYRPGIPHSDPRLPERDMDTHLLVNKDIREYLAQPSIEFAEEWLKKPDIPSSDEILGNFGSAENEYVELTPNKITGPWNSTDEYLKAHYELLREDAIAPLRDAVAYVRDDPQMTESKLVSIYDKVYFTGITFAQRGLGIRIRFSTRRAEKIIAWEYSKRLVSGSIVALSPADDAFQQKCIVAIVAARPLEGVQKHPPEIDIFLARPEDFEFDPQKEWIMVEAKDGYYESVRHTMAALQKLKQEKAPDYVKQDPILDIQSVASETAEAAEGHRVDILKSWPREPSQAMDTTQWQALHEMLTKRLSLIQGPPGTGKTYVSVIALRILLSNLKHGDSPIILASQTNHALDQLLRLVGTFETSYIRVGSRSNDPEIKRRTLYCVRQNEAAVTVHGSVLGAARKEQTVLTQTIAKILQPFNAENTNAPLPASLFIEYGLLTETQLDNLKKGAEGWTRPTDSEDTDPLVVWLGDKLVLFEVGYERESFGFEEDEVDLEYEQLKELEAEQGIEEDDYEILKGQFINLQDGVCGCKISCSETSAIENLKQKDLWKVREEARGAIYDVLRKQLKTKMTESLRRQVLLYSKNCENLLIGKWERDYHVLRTAKVIGMTATGLSKYRGLISSLRPKIVLIEEAAEAIEAPIVAACFDSLQHMILVGDHQQLRGHCTVQELGGEPYNLGVSMFERLVKNGMKYVMLNRQRRMAPEIRQLLEPIYGELNDHESVRKRPGVRGMGIIRSYFFTHAWPESRDSLASKYNDMEAQMIAEFVVYLVQNGNTVKDITILTFYNGQRKKLLTVLRHHPYLQGQYMKVVTVDSYQGEENEIVILSLVRSGENDIGFLSIANRVCVALSRARRGFYMFGNANSLAKQNQLWRDVLTLMANNKPPRRLGTQLPVTCVKHKRTTFIQGLSDWNKINGGCDCHCDGTLDCGHPCPIKCHSFSHEQVECNDICNKRMACKHVCTQPCVISHTCNCTCEVASQLDNLRLHHESQGSTAPLEGPSSYPEAVRHYQAFASGGAKEHDALLLRKATETAAAARPTPGTEEDEDLLLSETEVASSPQERDTAVPLSEENLMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VS04</accession>
    <name>A0A8G1VS04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_484397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520314.1">
        <property type="nucleotide sequence ID" value="XM_025663234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VS04"/>
    <dbReference type="GeneID" id="37166636"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000031">
        <property type="entry name" value="Topoisomerase family protein Trf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="7">
        <location>
            <begin position="261"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="6">
        <location>
            <begin position="457"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="585"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="590"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="669"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH62392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="682" mass="75794" checksum="5D014D626F7514E1" modified="2022-01-19" version="1">MPPAFEFRGNDRRSGHQPRHEFTFRYARPGTSERPLLRSKRETTPEQLLPSGAADSKPALKFAPVANLSDSEEADMDVSSEDEDEAAHPRKKRAVDPNNTGTATAAPAPPPAPKWSNPDPYTVLPPPDETQGKRVDVVKLIRKARIAATAAAQPTQEDAVKTNEDFISLSGLVDEDEGGGNAPEGAPTGPRRQLEGKDSAFGNRKRTYDDEIKGVSKKTGKPLSKYYDDGSIIDEWRARSSENATPWASSMAPSLHVGARLHNEILSFYHWVKPVRYEQIVREDLVARLQAAFQSRYYGVQLRPFGSFASGLYLPTADIDLVLLSTNFMRNGIKTFGERKGQIYAFSAFLKNLNIAVPNSIETIAHARVPILKFVDKLTGLRVDLSFDNDSGLVANETFQQWKAEYPAMPVIVSVIKQFLLLRGLNEVPTGGLGGFSITCLVTSLLQHLPHGHGTPNLGSVLMDFFEFYGNGFDYDSVGIRFNPPGYFNKRVYKLSFNNSPRLSIEDPNNADNDVSGGTREIALIFRAFSEAYQRLKERMISTATAGQTQASILEAIIAANYEEYTEQRWQLRQVFDTDERFARYRRDSTPPPPPPESPPADAAPPLPPNPPPAAPKSQKDKMTKLQKKQQAARERSARLKRLRPDIPSIPYSISNEQAISLGGYKSQSDMDRDLLMREKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSF1</accession>
    <name>A0A8G1VSF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF2 family helicase/ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_365518</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518650.1">
        <property type="nucleotide sequence ID" value="XM_025655743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSF1"/>
    <dbReference type="GeneID" id="37159145"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17998">
        <property type="entry name" value="DEXHc_SMARCAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000046">
        <property type="entry name" value="Putative SNF2 family helicase/ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="591"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="945"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="270"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="532"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH60728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1123" mass="124298" checksum="FF97686D4222C769" modified="2022-01-19" version="1">MEDTVPDTPVSDKKVVHSTPTKDDAAEYETVATVPVSHLQPLATQSSTPATQRYTQPTQVLDVPYSGKNNSFVQVAASSPPGPNSSPSHPTPNGGRLSSAMAPAGTSFRPPVGPAKRAPIIDLEDDGPTYRGGSSDDDDRASRSIDIKPSLFAKSSRSPEKVAESPMDRFKQITTSAVFNPSSAKRPAAQMDPAPRGTAVKKVRQDGPSRAQPVGTNVSSLQDIDDYQVRVKVERMLKVMPQKSVHACMQALLSKRGNYEAALEHLADTEKAESSEDELIASKRASPVAPAKQQIKARGTIQDKWSAMNMQRTLSAQKQQSQPSQPAEEDAKPRRRLMRGPKSRASSPSPVRSVPRVETPPKKTGRLVQGRKPASPQRSESPEAMIISDEDSDSGVEEPAGDGQVETRVLNFFNKCSVLDLADIAAITEDVAKHVISFRPFSSLDRARAVPPPAKEETKPKGGRGRKTPKPIGDKIVDKCIDMWVGYEAVDSLVAKCEALGKPVAAEMKRWGVDIFGKKEGELELVSINPRDAHSQSHDSGIGTPASQPSDEDSDGPAPGPRKGRFISQPGIMRDDLKMKDYQIVGINWLSLLFENQLSCILADDMGLGKTCQVIAFLAHLFEKGIKGPHLVVVPSSTIENWLREFSKFCPTLSVMPYYAGQAERAVIRETIEDNRDSINVIITTYTIAKGKVDAHFLRNMDFCVCVYDEGHMLKSSTSVLYEKLIRIPARFRLLLTGTPLQNNLQELASLLGFILPKVFQERKEELQYIFANKAKTVDESHSALLSAQRIERAKSMLKPFVLRRKKHQVIDLPAKISHVEYCEMNLAQREIYEHEKEEVRKLLADRAAGKKTGNKSANILMKLRQAAIHPLLYRRHYDNSTLSRMAKACLKEEQWSLSNPDIIYEELQAYNDFECHTMCVDHPHSLGRFALKNNEWMDSGKVDKLCDLLKRFKENGDRALVFSQFTLVMDILEHVLENQHIGFVRLDGRTNVEDRQSILDAFHERTEIPVFLLSTKAGGAGINLACANKVIIFDSSFNPQEDVQAENRAHRVGQTREVEVIRLVTKGTIEEQIYALGQTKLALDQAVAGEEGAESKKAEDAGMKVVEDMVLADMQHDKSDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSI2</accession>
    <name>A0A8G1VSI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_445990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the gamma-tubulin complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518755.1">
        <property type="nucleotide sequence ID" value="XM_025659393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSI2"/>
    <dbReference type="GeneID" id="37162795"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH60833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="79" mass="8682" checksum="C392D3614328AC97" modified="2022-01-19" version="1">MPSQADDKRQAAREVIDILHEISTLLNTNLDRTELSLCVSLIENGVNPDALAAVIKDLRKESGVPRGFANEQQQQGLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VT04</accession>
    <name>A0A8G1VT04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AtmB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_515986</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxB family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521422.1">
        <property type="nucleotide sequence ID" value="XM_025664820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VT04"/>
    <dbReference type="GeneID" id="37168222"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039020">
        <property type="entry name" value="PaxB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038:SF2">
        <property type="entry name" value="TERPENE CYCLASE AUSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25129">
        <property type="entry name" value="Pyr4-TMTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH63500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="244" mass="27513" checksum="F3CCE51BDB2E7F34" modified="2022-01-19" version="1">MDGFDATQAPAAYRAVEPIVNILTLAMTLGWLVNYASMIHISFKEKTYAMGIMPLCCNIAWEFSYGVIYQPKNRLELVVTVTALIVNVAIMYSAMRHSPNEWSHAPLVQRNLRYIFAVCTLGFLTGHIAFAAYIGPEVAYTWSAAFCQLLLGTGGLCQLLCRGSSRGASNLLWISRFIGSLSVLGMAALRWRYWPEAFAWLDNPLILWSAGMFLFLDLSYGLCYWYILRVEKKEALRQEHLAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VTF0</accession>
    <name>A0A8G1VTF0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vitamin H transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_361963</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519655.1">
        <property type="nucleotide sequence ID" value="XM_025655606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VTF0"/>
    <dbReference type="GeneID" id="37159008"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF32">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="59"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH61733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="491" mass="54451" checksum="DCC39C77A9AF961C" modified="2022-01-19" version="1">MVGRQFEFEDPKDGVVPPFEEKKVVDEVYTENDVASEEIVKDWDDKEEGKLRRKIDIILIPILALAFFGLQIDRGNISAALTSTITEDLGVTTNQINIGTQLLSAGIVITEIPSNIILQRIGPQIWLSTQLVAWGLVGTFQAFVQSYPAFLATRLLLGLLEGGFIPGALYYLSTWYKRPETSFRTTLFFYGQMFAGATSSLISAGLLKLDGKCGLAGWRWIFLVEGLITIFAAILFIMFIPKRAGDGSPLISMGRWSYFSPREKRIIIDRVLLDDPLKTREHIKITGRDIWMTVTQPTTLQHMFITLVAMSGFQGLNTYTPSMIKSFGFSAVRANALASVPVYASIVWTTILAYSSDKIGHRGPFVLLCITWNVISYACLRTSPTDASSWHKYSVIAIANVAYCSMHVLNVGWLSFYCKTPQERSISMALIVMSANLSGISGAQIFRSSDAPLYIHGLTAICALAAASWVQTLVLNLQYLFRRKKAQAGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRY2</accession>
    <name>A0A8G1QRY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_453293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511123.1">
        <property type="nucleotide sequence ID" value="XM_025661019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRY2"/>
    <dbReference type="GeneID" id="37164421"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055497">
        <property type="entry name" value="DUF7069"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031359">
        <property type="entry name" value="NACHT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23239">
        <property type="entry name" value="DUF7069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17100">
        <property type="entry name" value="NACHT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NWD NACHT-NTPase N-terminal" evidence="4">
        <location>
            <begin position="59"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="7">
        <location>
            <begin position="359"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7069" evidence="6">
        <location>
            <begin position="551"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="5">
        <location>
            <begin position="641"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="989"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH53201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1052" mass="119837" checksum="1DBB08B2E1E2EED0" modified="2022-01-19" version="1" fragment="single">MGCLGLRRLLGKKPTHEKHVQPANTAVANGAVGPRPAQQDRPVKATDASLSKETLARDESLWDQAYKNLDPGLVERYEELLAKQRQEINDNSCKNGTNRQQDLDIIINHGLHQAEIQRTGVQEGLAQAASWILSVKDFIGEAVKASPEASLAWAGVCIVLPLLTNPQSAAQANKSGFTYITGRIRYYVELERILWSTSSRSSDHTGLKEQFNANIVKLYEEILRFEVKSVLRFHRSWQRNFAGDIFQPEDWNGMVSSIKDLEKLVQQDAATISTEVSRRHLNEVEQSTRHNFESMQKLLPLAQRHLEVDMEALNLQRQMHEEALSDKEQKCRQLFRLARNEEDSSYELYKSRVDDRLEGTCEWFLEQPHFNQWLDNDRGLLIVSADPGCGKSVLAKHLIDNVLPQCNPSATICYFFFKDGDQNTQKQAICALLHQIFTNKPDLIKLALKVIDDNGQETVNVVTELWNIFSRVIKHPAMGQTIFVLDALDECKDSELVDLTDNIKSIQNDGGTRARFFLTSRPYENVISEFQELIDHSPHIYIPGENESDKIGQEVNIVIKHRVERLARKKHLSPTIQSYLEERLLRMEHRTYLWVHLVFEYFETHSFQKVQKGIDRVFIDKLPKDVNDSYCKILSKSEDMDMARKAFCIMLAASRPLTLTEMNIAVNLDLDADELDLESDEDFQASLRSWCGLLLTVNNKKVFFLHQTAREFLAQKNGFGRCSERGPIDPKEAQGVLAMSCITYIDKFMPRARQTNSAEDLTSIDINRDFSVYSADEWYSHIRAAALEDDQKLEPILARICDPKSAVFASWCEANLWDWGDCNTLWVAAKFGLTSVVKRILKNEEIEDVRGDRWRRQSIPHVAASCPNVDVLNLLLDCKKLDWRRKDEEGYTPLFHAIRSNHVASVRCLLNSGKADVRDECNGYTPLIYALLFSSDEMVEMLVHTEGIDMNGFWWGFNALTVAMRERRHNLVKLLLDMEAVETIPSSLESKTPLVVAVMQNDEAMVKLLLDSGRIDLNQQCELGGTTGTALKFARSGEFTRIVELLVEAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS62</accession>
    <name>A0A8G1QS62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HCNGP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_473035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825090">
        <property type="protein sequence ID" value="RAH51946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509868.1">
        <property type="nucleotide sequence ID" value="XM_025662598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QS62"/>
    <dbReference type="GeneID" id="37166000"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012479">
        <property type="entry name" value="SAP30BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464:SF0">
        <property type="entry name" value="SAP30-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07818">
        <property type="entry name" value="HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH51946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="235" mass="25690" checksum="1B0E6DFF0778D874" modified="2022-01-19" version="1">MLGLGAYESSSDEEVENNLPSVHSKKIASQQAQPQEVTKATAETANEATPSKDIPVPNTDRPVLGPTHEGSQNPQEQPAEHSQVFSADRTLIHDLTLPPIPNLDIPPSPPGSPNSAANAKFAHFLTLKKQGMHFNEKLAGSTSLKNPSLLKKMMDHAGIDEQAQYHTSLPPEIWNISDLPSWGYKEELLKAQREIQNRAEEKKSAGQRDAINFVPATPSEFSRAGPIPSSRPKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSE4</accession>
    <name>A0A8G1QSE4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_381333</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511363.1">
        <property type="nucleotide sequence ID" value="XM_025656413.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37159815"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF18">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="6">
        <location>
            <begin position="2"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="7">
        <location>
            <begin position="925"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="925"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="957"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH53441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="2356" mass="256492" checksum="04361BFA0B44FAED" modified="2022-01-19" version="1">MAEPIAIVGMACRLPGENFSPSQFWEFLKRGGLASSEVPESRFTIDTHYDETRKPHSMRTPGGKFLEKVDLRDFDAGFFNISPGEATAMDPQQRLLLEVVYESLENSGISLSTVNGAQVGCFVGSFLSDYDYIQARDPDNRPNFILTGIGRAILSNRISHVLNLKGPSMTIDTGCSGSLVGVDVACRYLSAGDVDSAIVAACNLPEHTTDPSSTGAIYTGTGQCHTFDAKADGYAKAEGVGSVVLKRLSDAIRDRDPIRGVIRGWAVNSDGQTAGISTPDAVAQAECIRAAYAKAGIEDRSLTPYVEFHGTGTKRGDLTEVEGINLAFNPAENRDQPLMISSVKSNIGHGEAVAGMNGLLKAILTVENGMIPGNPTFLEPSPLIDLKKLNLHVSNRATPWPQDALRRASVNSFGYGGTNCHIVLDGADMWMGPSGPFHKSSYSSNKGGLMLDDDSDDEDGTEFKRPFLLVQSASDEYSLKNNCTELARHFSKINVKAELRDVAYTLSERRSHHMHRAFAITDRLQISENDFVHGKVDVQLPHICFVFTGQGSQWPQMGKEVLQTFPVAADTIKELDAVLQTLPEAPSWKLLDELTESRDGSHIRQPELSQPLVTALQLALVDLFRSSGISPKGVVGHSSGEIAAAYAAGYVSKADAIKIAFYRGYAAKVHPMNSVGMMAVGLGPEAVQPYIEKHQDLVQIACINSPQSVTLSGRTDGLEAVKEPLVADGHFARLLQVDLAYHSRFMTEIGESYHSLLLSNIACGETGTDTTTMFSSVTGSRMEAIPDATYWKRNMVSPVLFSGAVQEMVNAHRGSNFVVEIGPSATLAGPIKQITESVTQAGINVRYAGLLSRKEGLLPLFRTVGNLYNSGVSIKLDSLNRTRDDETTKPAVLVDLPNYSWNHTTKYWYETRPSRDWRFRRFQHHDLLGSKILGTAWQSPSWSKILHLREHPWLKDHRIGDDIVFPAAGYVSMAMEALYQAKVATDAIQTQDRNELQYQIRDLRLTKAMVLDENLPAEIQLVLESHISPNGPWSRFKISTLRDDVADVNCTGLIRLDQGAPAAVPPQDLTMRGAQTQGALWYSSLTNAGQNYGPAFQRIKGVKSLPGVQRTVSELLIRDEEQEKGQSSYPLHPAPMDTILQCILTAIWQGDRTLIPGPAVPVQVDSFTIFPMAGSSPYATCVATSGYKGHGRPTDPHSLKSHAYLHDSQTGAILASIEGMVIQPLGSSGINRVDTSPVAPVWRPDVSLLQDPAQSPRATMEMPTMEVQALIDLITHKTPFMNVVEVNLTQVSTSLWLGGAESKRNRKFRDYRFLLGHSGAAEEAREQLADRGVRVGYIDPASSKLGTVSGEIDLLIIHYESDTQLQTLQNLVPDALKLISPNTGTVLPVQKLTPHALMNGNTPTKPSEVLDQILQAASYTAVLTAGDPAGEAILWRGSNLALIPEKTRTVAIARFRGDALPLGSLAKALGRYNYDFQEHFYPFAEIPTDAIVLVVDEVQSALLAEATDKIWNGFKTLVDRHCRMVWVTRGALVQVSNPTNAVSHGLLRTARLEDPSQAIINLDIEGDLGSAAGCAAIVEMLFRVEHLERAKAADCDFAERGGLLHVSRLENQSAIEGFHEPLGGSQPLTELKMHESDSIIRLQTGTVGSIESLRYVQLPSNLSELSEDKVEVELYASGLNFKDIAISMELVDEDEHMLGSEGAGIVRRVGRNVSGLRCGDRVAVISQGCLANRIQASPSNVIRIPDSMSMEAAASVPVAYCTAVLSLLHLASLKKSQSVLIHSATGGVGFACIKLAKYIGAEIFATAGSDEKRSYLHEAHGIPKSHIFSSRDSSFASGIMNVTNGKGVDVVINTMMGEMLEHSWRICAQDGVLVELGKADIRSKGYLSLEPFDRGCSFRALDLTLALAQPERVSSVLREVFQLIEAGHVPPVEERSVYTYDKVKDVFAQMRSSRHLGKLILCNGEGQDCVVPVQTAVQQPAIRKNASYLIIGGLRGVCGRFAISLARWGARNLVVMSRSGLGDEKSQTIIEACRRLGCTIEDIHGNVLSPTDVGRVFDTARLPIAGVIQGVMVLNDKPLETMTLEEFQSTLSGKLHGTWNVHHAAVERGLSLDFFSMLSSILSVMGHVGQANYVAGNIFLDAFAEYRQSLGLPAHSINLSAVEDIGYIAENQGNWQRHLPLNDISLIREMHLESILRDSILQQMDPSQKRPGITQLVVGMRERINTDSQYARDNRFLPLIAQGDEGGRADGPGGGSGELANFIDVATSASDPAAVVGHAVNLFNIQLTKFLHLAEPMEPSKPLGAYGLDSLTAMEFRNWLRDTLAVEMSTLDIASAGSLYSLSERFVSKFLAARKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QST6</accession>
    <name>A0A8G1QST6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_382733</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KZ825080">
        <property type="protein sequence ID" value="RAH52937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510859.1">
        <property type="nucleotide sequence ID" value="XM_025656480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QST6"/>
    <dbReference type="GeneID" id="37159882"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="77"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH52937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="553" mass="60620" checksum="43D96404044FF4B6" modified="2022-01-19" version="1">MSLSWELQAQKAKDILQQSIPKQWLLPAHKLPSADLKNVEDFPRKSGLLSARELSITDMSAATLVQNMGAGKLTAEEVVVAFLKRAVLGHQLLNFATEFLTDRAIGRAKELDEYYRRTGRLVGPLHGVPISVKEHVGVKGHTCNAGYVAWVDDIATEDSLILQCLEKAGAVFHVRTNQPQSLMHLCCSNNLTGTTLNPYNRTLSAGGSSGGEGASTGFKCAPLGIGTDIGGSIRCPAAFCGSYGFRPTALRNPLSGAKAPKEGHESIRGVIGPLASQSVEDMDIFQQAIIDQEPWDVETSLVPVPWKRAKPTKNMTVAIMWDDGVVRPHPPITRALNHAKSKLLAAGIKVIDWEPYKHKHGWDIISAMYFPDGALSQRKLIAQTGEPILPLTAWAFDYSSPTPLTMAESWTLNVQRDVYRDEYHALMKSRGVDFILCPVYAGVASVLGESHYWNYTAVWNILDQPAVVFPSGLSVDAQLDQLTSEHKTYKPRDEVDQREWSKYTGPERYEGAPIALQLVGKHFKDEETLAAGALVDGILKGGAERSTTTRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSW9</accession>
    <name>A0A8G1QSW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_381899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511185.1">
        <property type="nucleotide sequence ID" value="XM_025656443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSW9"/>
    <dbReference type="GeneID" id="37159845"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05132">
        <property type="entry name" value="RasGAP_GAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="186"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="780" mass="90248" checksum="8217C15C1E4127A4" modified="2022-01-19" version="1">MSVATMLQPASRASTSSSSSFQPVTRQNTMSSHDTRSLRQSKRLSVTALYMSMNAKDRDLDISDDLARAQIYLRELKAKISTQSKKNFVLEKDVRYLDSRIALLIQNRMALEEQNEVASHLDDAIDPQEGFFPNDERTQKYGNLLFLLQSEPRHIAHLCRLVSMSEIDSLLQTVMFTIYGNQYESREEHLLLTMFQSVLTYQFDNTPEYSSLLRQNTPVSRMMTTYTRRGPGQSYLKQVLANQINALIELRDVDLEINPLKVYETMVKQIEEEQGSLPESLQRSVTAEDAAANAQVQAIIEPRLKMLTDYANRFLNIIIESVEETPYGIRWICKQIRSLSRRKYPDAQDQTICTLIGGFFFLRFINPAIVTPRSYMLIESTPTEKPRRTLTLIAKMLQNLANKPSYAKEPYMAKLQPFIQQNKERVNKFMLDLCDVQDFYESLEMDNYVALSKRDLELQITLNEMYATHALLEKHSLALAQDQHSHLNEILQELGSAPPQVPRKENRTITVPLFSRWETSLDDLTAALDITQEEVFFMEAKSTFVQILRSLPPKHPAMRRPLRLYLIAESAATLKNDAVMVRKGIRTIELLDQLMKLGVIERADDFSLLRDEVEQELAYLGGLKENVLKETKKLEEVFATIRDHNAYLVGQLETYKSYLHNVRSQSEGKQRKQQKHQELGPYKFTHQQLEKEGVIRKSNVPENRRANIYFMFKSPLPGTFVISLHYKGRARGLLELDLKLDDLLEMQKDNQEDLDLEYVQFNVSKVLLLLNKRFARKKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSZ8</accession>
    <name>A0A8G1QSZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_453416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825079">
        <property type="protein sequence ID" value="RAH53027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510949.1">
        <property type="nucleotide sequence ID" value="XM_025661048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSZ8"/>
    <dbReference type="GeneID" id="37164450"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF7">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="2">
        <location>
            <begin position="32"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="273" mass="30886" checksum="C3254093A325F248" modified="2022-01-19" version="1">MPHFTLDDAATQSPTGLTRHLNTTVEEYVFPILIALSWCNAIELVILCLNTFKRYTGTYFWSLLIASLSIIPFSLGYLLKMFGLTFTNYFLEISIVGVGWAGMVTGQSLVLWSRLHLVLHQKKLLRGLLYLIIFDGVLLHCSSEGLELAVNAMPDSQPVNVAFGIMERIQLVWFCAQELLLSGLYIRETARMLRMDSGELSRSVLVQLLLVNVVIIVLDLSVVGIQYAGFFTFQVTFKALVYSIKLKLEYVILGRLVDVAYVRSQVDTPRFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QT04</accession>
    <name>A0A8G1QT04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular proline-serine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_452926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511663.1">
        <property type="nucleotide sequence ID" value="XM_025660943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QT04"/>
    <dbReference type="GeneID" id="37164345"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF2">
        <property type="entry name" value="EXTRACELLULAR PROLINE-SERINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_8G07090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034032962" evidence="3">
        <location>
            <begin position="17"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="258" mass="27417" checksum="83AA078031FC266A" modified="2022-01-19" version="1">MRFVIPFLTLSSLAAAISITEPALNSTYAAGSTITVNWTTVDTDPTTFSLYLWNFVYWPPSYVPLAIDIPTSDLSYPVQIPCDTDPEWGYQISGINGTNVYIIYAQSEKFFVSDAANATDCVDTSITAPGASATSTCPAASTVYVTVSPTASSTALFHHSHHHDHHLLHHHSSHLPAPSSTPAPASSRSVKPGIVPKTIGWCSDYSHPVTLNKVPTPTAALYETETASQASTQDVSFVTATTTMSVVGSAESDGCPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTE6</accession>
    <name>A0A8G1QTE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_463224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511174.1">
        <property type="nucleotide sequence ID" value="XM_025661909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTE6"/>
    <dbReference type="GeneID" id="37165311"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42077">
        <property type="entry name" value="YALI0F30239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42077:SF1">
        <property type="entry name" value="YALI0F30239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="140" mass="16053" checksum="E574B8E58CB859F2" modified="2022-01-19" version="1">MTRLYPLFILLFVLLILGTIFYITYSIIQDVKRNTRSKMEKKNVTFSRDGVTVGVKELKDEDYLDRSQSILVSMWNHTSFPAYKSRLWDMTKPTNWNENGAGGSSGDDGLRDRFWSAAGKVGEWAGYQQGQEGERDKKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTU2</accession>
    <name>A0A8G1QTU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_381378</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511399.1">
        <property type="nucleotide sequence ID" value="XM_025656415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTU2"/>
    <dbReference type="GeneID" id="37159817"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH53477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="491" mass="56202" checksum="8005DDB4F54E4428" modified="2022-01-19" version="1">MESMIDAIQARLADDEPLLAQPMVVAGALLFLLVVFQLRRAGGSKAFPSPRLGYPLVGDALAFLNRPVAFVQDATRKCGPIFHVKILFANIVYLRGTQLNRMYVDVKEDIWSFGGGIGIFLKKIAIPGYFDHFRNLVGSLNRGINRKVTLDRYTELAGEEADKALLKWSQQSDIKLFEEASKYVHRVIVRTLMGQDFYDEHVDELYDLVHRMEDEIGHPLNLLLPDWFPHPPARRLGKARDRFAEIFAQQMEIRRQNPEKWKGSLDYITYTLEDPRTAHLQEYYPSHHTVLMFAAHTSTVASIAWTALELIRNPEYVEAIRQSFQNNEDVHQSPVLLACVKESGRHYSGVHMWRTTHRPVQLEDGYMVPENWVVCTSPYLTHHDPEIYEQPQQWLPERWLHPTARLQNLNNATDAAFLQFGAGSHRCPGENMAGIIARELVSRLVKNYDFQWGSQGPAKIDVSRMDFSKVGSPWLQGDARIRLTPRKSAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTW8</accession>
    <name>A0A8G1QTW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_151590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511695.1">
        <property type="nucleotide sequence ID" value="XM_025654150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTW8"/>
    <dbReference type="GeneID" id="37157552"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02233">
        <property type="entry name" value="cupin_HNL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047263">
        <property type="entry name" value="HNL-like_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43698:SF1">
        <property type="entry name" value="BLL4564 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43698">
        <property type="entry name" value="RIBD C-TERMINAL DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="44"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="132" mass="14387" checksum="781D79F6158528F1" modified="2022-01-19" version="1">MPESIIIPSAHKPDAKSAKPTATFTGDVYLDPIHFASDASIANVTFTPCARTYWHTHENGQMIKVVAGNGWICDKGGVPRRLNTGDVVWAPAGTTHWHGADEESVMTHFVVGLGKTVWHEAVSEEEYKSKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QU23</accession>
    <name>A0A8G1QU23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_452885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511580.1">
        <property type="nucleotide sequence ID" value="XM_025660927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QU23"/>
    <dbReference type="GeneID" id="37164329"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH53658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="254" mass="27061" checksum="3C4312CC54D2A95C" modified="2022-01-19" version="1">MSLFSLSGKTALITGGTRGIGQAITLGLAEHGADIVLVQRSTKISDTQPAVERLGMRCEVVQCDLADREQVEGLISTVVATHSVDILVNCAAIQHRSPAVDYDTLHYEAVMQTNLTTPFVLCRDIARHWISQGKRGKIINVASVGSFQGGINVSGYAGSKGGLLQLTRAFSNEWAGNGINVNAIAPGYIETDMTADTLAEPQHAAYRESIIPRIPVGRWGKPEDIKGVSVFLASQASNYVSGEAIVVDGGWLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUJ0</accession>
    <name>A0A8G1QUJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tubulin-tyrosine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_381999</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511143.1">
        <property type="nucleotide sequence ID" value="XM_025656448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUJ0"/>
    <dbReference type="GeneID" id="37159850"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="227"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH53221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="348" mass="38827" checksum="42B50F4A27F51C39" modified="2022-01-19" version="1">MIVTSTVAYGVFYYRFIPQAGLERIVHLQFGEGPPWGIASLGSDLVSSLPYDVQVELELPRTPSNLAAGNFMLDLALLSRPFTSTPQDTNTSITTLSHSRRPAILTYASPLVDTASKISFMPFYVLGWHHEAEKLQVPMMERVQFARGSRNIPESLRLELHSSEIMQVYKAKVMFRARFTGLRKVSWVMYNWRLTSFVVFGFLFWSISMASAGLAWLFLASLLSSRDDTSGPVVVKEEDRSATTLIKKEEEEIDEPLSDVPIAESSNAAGKRRAIEPEEAVKEEDEEDDDEEGDVGSADEIALNKYLFEGDAEDGRGEEPLEASGSGTARESAHARGVQRRRSHIIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUX5</accession>
    <name>A0A8G1QUX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_378736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512743.1">
        <property type="nucleotide sequence ID" value="XM_025656311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUX5"/>
    <dbReference type="GeneID" id="37159713"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="490" mass="55519" checksum="A8D0280C4A4F8673" modified="2022-01-19" version="1">MPGKLVERRNRIIYPLSVTQLDQRDLTSIVEILLVDSEKDRAKSAYLGQYRGYRTSKNIKTGIQTLRWQLQANAMFRLLFGPSKIVLCEVHKGFNPWIIHSLFELLVKEVTSFLDELYWFLEYLKDDVKEMLRALNSIAGMWWCPKSRHDLPPFHARYYQENRCEACMLARVVAKAPDLQNLHATLLSRTREDRSEKHPELQKFVEVAISITGVTPDMLRDGMGLAVRARAARKAARKFARKQMKGPRPMRYKGKKKRSHCITIRLKAETPEEAEKERKEILEMLARLKGEPSEKLDDLANDMVREFKCDVERTINAKHEKLPDYAENEHVSMPAPSHHRVSLVSEAEVSDCLSEDPSINGEETDMTPAPSYHSNLNGLGSQEPPVVGANSLNSTTYCSPTVATGSSNTDQATGIRSRLGDDEPILSIYEEARRSSDRFPVEGKSNGSALPPLMPDTPGKKSVKFAAPRHVAPVYGSRLPQNFLRFRTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUY8</accession>
    <name>A0A8G1QUY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tyrosinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_504554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511259.1">
        <property type="nucleotide sequence ID" value="XM_025664303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUY8"/>
    <dbReference type="GeneID" id="37167705"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034621072" evidence="4">
        <location>
            <begin position="21"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="6">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH53337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="341" mass="38410" checksum="C2C31BF3CF136169" modified="2022-01-19" version="1">MKFSSFAVALALAATTSAAAVPHSSANTDQSETTSHDIPGFFSRSCTREKMTVRKEWRHLTTHEQNSFLDSVQCLMNKPAQSGLTATTSRFSDLQALHRGMTNTAYADIIHHVGQFLPWHRYYMHIYEALLRNECGYSGPMPWWDEQKDADSGNMWQSSMWGADAFGGNGTGSDYCVRDGRFSNLTLHIGPGDEDTDYCLRRAWDTKNAIANANSTALEKCNAYNTYAPWWNCISNIPHKGVHTYIGGVMADIKSSPGDPIFFMHHMYIDRVWWKWQQQDPINRLYDISGPTLNHTANVEPAGGWQNATLHYELSSFNIMPNVTIAEVMNTQGGYLCYGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV56</accession>
    <name>A0A8G1QV56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="4 8">3.2.1.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_427449</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Endohydrolysis of (1-&gt;5)-alpha-arabinofuranosidic linkages in (1-&gt;5)-arabinans.</text>
            <dbReference type="EC" id="3.2.1.99"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="4 8"/>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512340.1">
        <property type="nucleotide sequence ID" value="XM_025658154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV56"/>
    <dbReference type="GeneID" id="37161556"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18831">
        <property type="entry name" value="GH43_AnAbnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.115.10.20:FF:000005">
        <property type="entry name" value="Arabinan endo-1,5-alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034765006" description="Arabinan endo-1,5-alpha-L-arabinosidase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="10">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR026534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH54418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="321" mass="34567" checksum="BAD19008E0B7A155" modified="2022-01-19" version="1">MYQLLSIASVPLLASLVHGYANPGACSGVCTTHDPGLIRRESDGTYFLFSTGNKISYVSASSIEGPWTSVGSMLPDGSSIDLDGNDDLWAPDVSYVDGLYYVYYAVSTFGSQDSAIGLATSETMEYDSWTDHGSTGIKSSSAKIYNAIDPNLIYADGTYYINFGSFWDDLYQVPMKSTPTAAASSSYNIAYDPSGTHAEEGSYMFQYGDYYYLFYSAGICCGYDTSMPASGEEYHIKVCRSTSPTGDFVDADGTACTDGGGTMVLESHGEVYGPGGQGVYDDPNLGPVLYYHYMNTTIGYADSDAQFGWNTIDFSSGWPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVD7</accession>
    <name>A0A8G1QVD7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_403690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512270.1">
        <property type="nucleotide sequence ID" value="XM_025657239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVD7"/>
    <dbReference type="GeneID" id="37160641"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="224" mass="24931" checksum="848E89550889BEA3" modified="2022-01-19" version="1">MNSPSADDGVTIALTLTTDSSTLSLSSSHSLEVFVCARIIHSTCPGRSVTITADRSVFAGEGLEIGVFGLGAVSRQDPSRVIDFGIIRPRYHDDFEGPSLSERGYRLLTIPADDTGIVVPYEISFDRLFEHSTLRPEDITPGEEFEIKVNHGRCEVLWWCWGDVEGELKGKNLHTWSQGGNYLCSLDDRPSEKEIREKNYILGGDVDKFKVEDQTRPIAIRMIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVZ9</accession>
    <name>A0A8G1QVZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_85797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512805.1">
        <property type="nucleotide sequence ID" value="XM_025665736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVZ9"/>
    <dbReference type="GeneID" id="37169138"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="424" mass="45865" checksum="85A20AA30CD44E80" modified="2022-01-19" version="1">MGSPAIDVDVCPNPRTKEENQERAFIAASRRKDRSLDARVESANRASSLHKQRTGKALLISREIVEREAMYEEVDDRYQEKINRMLHAQSMQLQTEFNRNLMAAFANRPSALHQRRASSHLNPRASLNGIRKMSLDLSGLRASVSDGMNTGPMTSPLAPHQGSYVLSPTYDGNSQSPSYPSVVPASSGQLPSYLTQTAGGPTWPTQLNGPQPMRSPWTGGFVSPVQQVPATTMGEMGAMPVRQFRDRMGSAPVIPVHAMPSPLLATPAASSNSSATVPPTTTTTSSSSSTASAGPRPAHPMYQHTRVRSEPGQALRTQSLANLSQLNSPPGMPMDSTEPVPTPDLCPTPSTPQSPTSTGQDPGLWGLDLNKDEGVMGYAQEHHMDPDYEDFSRFAFTLGSGPQLPESETAFDEFFTMEDFPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QW16</accession>
    <name>A0A8G1QW16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_348730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511157.1">
        <property type="nucleotide sequence ID" value="XM_025655480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QW16"/>
    <dbReference type="GeneID" id="37158882"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="124" mass="13071" checksum="3D20A55D9681BDC0" modified="2022-01-19" version="1" fragment="single">MIFGTNSTSIPSTRTLTTTPGPSSPMDDEDVVEVVDTAASTSSSSSSPPSTRLMAVGKCKAELKSGNIGLDCPCNRGIFSLTHTNDISDQCIDCEHSIAEHEGIDIDIQRKGMSFPSLIPPLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QW36</accession>
    <name>A0A8G1QW36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_451830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825070">
        <property type="protein sequence ID" value="RAH54943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512865.1">
        <property type="nucleotide sequence ID" value="XM_025660680.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="37164082"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="85"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="171" mass="19104" checksum="D4D9BD5B92EF6C7A" modified="2022-01-19" version="1">MADEGASPRELVVEACRRDQPHLIEGVLERMEGKSNEEVAEFFNGVTDSMGNHALHICATYGSYDVMDALFDIQYFECDPLTRLDKDTPLHTAVRYANEKDAELGEAMIKMMCEAGCDPRVRNKHGQKPADLVYNNQEIKTTLQQAEYIMAEGLREDADNGSVHDSASDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWU1</accession>
    <name>A0A8G1QWU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TDP-4-keto-6-deoxy-D-glucose transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_138257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511981.1">
        <property type="nucleotide sequence ID" value="XM_025654055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWU1"/>
    <dbReference type="GeneID" id="37157457"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019180">
        <property type="term" value="F:dTDP-4-amino-4,6-dideoxygalactose transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012749">
        <property type="entry name" value="WecE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02379">
        <property type="entry name" value="ECA_wecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008687">
        <property type="entry name" value="PRK11706.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244:SF34">
        <property type="entry name" value="DTDP-4-AMINO-4,6-DIDEOXYGALACTOSE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="399" mass="43916" checksum="CAD50CC79082F209" modified="2022-01-19" version="1">MPGASIPTFQPTVTGQELEAIQEVLDNRILTGKGKYTALCQRWLESSMPHGKAFVLSSCTSALEIAAFLADFRPGDEVIVPSYTYVSTVNAFVVHGALPVFVDVEETTMNIDAQKIENVITPRTKAIVPVHYAGIACDMDTILDIANRHDLLVIEDAAMACGSMYRGRALGTMGHLGCISFQEKKIFTSGGQGGALLVNQDALVARAEILYEHGTNRAQFLRGEVDVYRWLDVGINATLSEIQAAFLYAQFQAAPEIISRRRRLWSRYHKRLAPLAHAGIIRLPQPAAEADHNAAVFWLRLANASDRPAFIEHMAAGKIQTQAQFVPLHSSPFGKQVGRFHGEDRVTTRAAAEIVLLPLYAELTERQQDLVIQRVWGFWREATNIPTLGDPPDAEVIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXN5</accession>
    <name>A0A8G1QXN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SPX domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_73283</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513440.1">
        <property type="nucleotide sequence ID" value="XM_025665624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXN5"/>
    <dbReference type="GeneID" id="37169026"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000002">
        <property type="entry name" value="Vacuolar transporter chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF2">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 3 COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="661"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="10">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="534"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH55518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="794" mass="90864" checksum="979252CC9593F194" modified="2022-01-19" version="1">MRFGKTLRNSIYAPWAGKYIDYNKLKVLLREHDVTGDGSDSESNPWTEQDEEAFVQELINVQLDKVNAFQMETLQQLRERTTTCEARLRPLTTSPEDDAPTVVDGEEKKRVASDVLQELDNITKEVTELEKYSRINFTGFLKAAKKHDRKRGTRYRVKPLLQVRLSQLPFNSEDYSPLVRRLSVMYSFAREILSQGIIEAKDPVEPRVGQDVYSSFKFWVHADNILEVKTYILRQLPVLIYNPGTSKDLNTIPDDPTITSLYFDNPQFDLYTQKVARAPEAGSLRLRWTGNLRDKPAIFLEKKVVTDDDRSREVKVQLKQKHVKEFLDGEYRCDKKVHRMENMGNGDSEQAEAFKKDVDELQSFIKEHNLQPMLRANYTRTAFQIPGDDRIRISLDTNLALIREDALDELRPCRDAHEWHRRDIDDAGMEYPFQSIRTGEIARFPHGLLEIKIRGDVARSAEWVKDLMVSHLVKEAPRFSKFVHGVAQLFEDYVNSFPFWLGELESDIRRDPETAFHEEQERLAKRAEDDMAVGSFLGGKTPSTRHIVGSPVQMFTETGPSRRRQSSQIVQPIPRPSAPTMSQPTPERQEPAEQSAAEAEQPVTMKRLASLFPSFTISRQNRAPADNVVLPPGVREPGTWIKDSGPVRVETKVWLANQRTFIKWLHISILLSSLSLGLYNAAGKHNDIARALSIVYTCFAIFAAAWGWYMHEKRARLIRQRSGKDLDNMFGPIVVCVGLAVALVLNFAFKYNSTMEKLRNREPAVMEPLPGLNSTAFLNKANMWQLVNQGGQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXW1</accession>
    <name>A0A8G1QXW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_404350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512087.1">
        <property type="nucleotide sequence ID" value="XM_025657268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXW1"/>
    <dbReference type="GeneID" id="37160670"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1760.10:FF:000002">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH54165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="188" mass="21217" checksum="D80B6626671FA3FF" modified="2022-01-19" version="1">MPAYHSIFLEDRDVPVIGNFPILPLRTRTRGPAYTLPPLPPTADTTDVPADSESYDCVDEILSLFRANVLFRNFEINGPADRMLIYGTLFISECLGKVKPGMVMREAEKALINAALDHFAIPGDVSFPLNQAFEAPRDRQDAETLRQYLSQVRQEIAMRLHARLYPGGVGPSKWWLSFAKRKFMGKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QY32</accession>
    <name>A0A8G1QY32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_440495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513604.1">
        <property type="nucleotide sequence ID" value="XM_025658770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QY32"/>
    <dbReference type="GeneID" id="37162172"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="218" mass="23787" checksum="BE9CAAC4A2970D6E" modified="2022-01-19" version="1">MGAGYPCSTARLPSTLPPDLCIRFLSFLSQNAHTSEAPAMTPRGTPTPTPMAVSRPAEDEEEDEEAEEDATEADELDEVHVLFPDDASAVEFASAAYPYSIFPVATSNEFPCGQITSLPLLIGVPQQYVETPFSYRRFIIEQPPSLLISSTQYKSAKDGQLSDSQFGSVHAPRDRTYGCSPVSMQRLFDKQTSDFPQHAVYVSDEQGTLLLAMVPSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYA6</accession>
    <name>A0A8G1QYA6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_424816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513851.1">
        <property type="nucleotide sequence ID" value="XM_025658056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYA6"/>
    <dbReference type="GeneID" id="37161458"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF1">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH55929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="176" mass="21003" checksum="C4B0C2703F4C3D60" modified="2022-01-19" version="1">MNNTAEELPALSVQDFRIYNRGAEKMDYFHGFLRRSWNILWDAATSGQRPSNMTVRQFIAEGLQFADHLETHHGIEETYIFPYLAKKMPEFRTGRGRHSAELLRQHREIHHGLEELREYLARCSQGEEDLDLRVLRGKLEGWREVLWTHLDQEVKTLGAENMRRYWTKEEMMRIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYK0</accession>
    <name>A0A8G1QYK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein Pth11-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_69719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513859.1">
        <property type="nucleotide sequence ID" value="XM_025665598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYK0"/>
    <dbReference type="GeneID" id="37169000"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF163">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_8G05510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="39"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH55937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="363" mass="40865" checksum="FFED7881083AC35C" modified="2022-01-19" version="1">MSSPFGEPPKGLNLEEDSTGRNDAVVVCMYALAFVTIGFRLFSRIKVQQANIGLDDWLIIGALLSGTANMACAIAGGHYGLGKHVWVVTLDEIINMVHILYANVLLYILTVPLIKVSIILSYRRLFGMQWTMWACIALSIAYWIGCSVAFLCSCQPVSYFWTQYENPLGGYVRYDIYPFYIAHAVANMVGDLLILLVPIPLVWRLKLRVGQKIQILSIFLLGGFVCVASAIRIYYFTFINDVDVTWNLGNVFIWSSVEPSIGIVCACLPVLQPLFRTIINRRSIPNRTTTKGVRFAPDIMSKIHGDDRRQTREDEAVLTTTSVHIEMDGAGKGRISDEEEAMGYDLMSIKVQKDFQMEEEHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYL9</accession>
    <name>A0A8G1QYL9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-deoxyglucose-6-phosphate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_375764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513889.1">
        <property type="nucleotide sequence ID" value="XM_025656188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYL9"/>
    <dbReference type="GeneID" id="37159590"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07527">
        <property type="entry name" value="HAD_ScGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="226"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="376"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH55967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="550" mass="59336" checksum="1717903E56EA3017" modified="2022-01-19" version="1">MSPETQFSEMEVSYTFAGVLLDFDGTIIDSTEAIVENWKRIGNELGIDHEEILRTSHGRRSIDVLQRLDPAKANWEYVSNMESQIPTLSKTPAVEIPGARNLLESLTKLHIPHAIVTSGTKALLNGWLNVLQLPQPQHVTVAEDVTLGKPDPEGYRKGKEKILASRENGDEGSKDVLVVEDAPAGIRAGKAANCKVLAVATTHSVEMLKEAGADWVVRDLRVFITGATGYVGGQTAVTLIAAHPEYDVVALVRDQEQADKLKSRFPNISTVIGTLDDDAVLKEEAAKADVVLQTASSDHVPAVNSLLAGLASGTGRGRYIHISGTGVLNDMSTGPGNPTSKIYDDVKDIHEIINLPAEALHRNVDDAVITGGMRLNVPTAIVCPPTIYGVGEGPIKKRSMQIPFLTEAILNRGKGFTVGKGENLWDYCHVSDVAKAFLVLAEEALKPNGGSATWGPEGYYFAEAGEFSWKGVSEKVTQIAHESGKLATADIETLAVEDAIKFHPWAPVLWGGNCRSRASRLRALGWKPEGPSLWEAIPSIVEFEIRALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZF8</accession>
    <name>A0A8G1QZF8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TPR repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_489709</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513629.1">
        <property type="nucleotide sequence ID" value="XM_025663621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZF8"/>
    <dbReference type="GeneID" id="37167023"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21381">
        <property type="entry name" value="CTWD_TTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000611">
        <property type="entry name" value="TPR repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="6">
        <location>
            <begin position="312"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH55707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="428" mass="48391" checksum="03FE069B6A85B041" modified="2022-01-19" version="1">MGQIEELPDDYDESLEVNKQPQQPPATEAKDEFTPPPPEELPIPIKEERLKDLNAGADPMAPQMPPAMEAVSTHTTDELADILNRTPLFMTDINKAYDENGENPFLDAIRALQNEGTRGDVAQNFREQGNEAAREKRWADAKEHYSKGIAVLLAKEDKWDKPEDEKEEARLRREVEEACYINRALCHLELKNYRSTTLDCAAVLKLNPKNVKAYYRSAMALFSLDKIVEAEDVASRGLKLDPNNKALQMVAGKIGERKAVLERIAARKKAEDERTRKEKTLLSVALKARQIRTRKTDQPPEMEDVGIRLSPDPLSPESTLEFPAVFLYHMDAQTDFIKAFSEMHSIEDHLDYIFPLPWDQKGEYKINTVECFMETVTGGLIRAGKKVPLVQILSGGKVEVVDELVKIYIVPTSKSAKFIAEMKARKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZP2</accession>
    <name>A0A8G1QZP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_514082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515293.1">
        <property type="nucleotide sequence ID" value="XM_025664741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZP2"/>
    <dbReference type="GeneID" id="37168143"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF7">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="354" mass="39568" checksum="B07D19B8F2372953" modified="2022-01-19" version="1">MSTTATITTTTTTTTAEPPKSQVYGQGQNRMLLDGKPTNYGDFRDALNRDGYAVIKGAIPLDRANGYADAFYSNLGYNRHDPSTVRRAKLPVLNEKGMILDYGVTHEQWVWDIRGEEGVVDAFKKVYDDEDLIVSFDVVNVGFANREDLPENKPWPHQDQDPSKPGFRCLQGLVNLLPNGPNAGGLIVCKGGHALSAQFHTEMAHEERIPAWTTEWFGFTDAGMKWLADHGLKWEKVCAEPGDLIVWDSRTPHYNVPPTGGQDRFAVYTCFMPVREVEKEDLVRKKGAFESRLGTTHWPHAKHVSKTNIAMRDGKPCPVARERPVQEPVLSERVFKLTGIPYLERMEGGAEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZY6</accession>
    <name>A0A8G1QZY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_40054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514640.1">
        <property type="nucleotide sequence ID" value="XM_025657126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZY6"/>
    <dbReference type="GeneID" id="37160528"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="171" mass="19480" checksum="D46F0EF6735687A7" modified="2022-01-19" version="1">MIQRVHRGPGYRSVSDSLVSPAYSIPNRPWSRRSGGAADAGLAPLMLGLCLDGRQTRFSLMSGEPAGKSLFVVLIFYFLFFFFFSTWKVKLFLGLGSCQLFSPRRVSIPPWQTYLRTVSISGRTCLLLVSTNYGAWPVHRGDWCTYTNPNPLTFPPWILVVKFRLRRIFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0J6</accession>
    <name>A0A8G1R0J6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_519756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH57851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515773.1">
        <property type="nucleotide sequence ID" value="XM_025665075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0J6"/>
    <dbReference type="GeneID" id="37168477"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="116" mass="13314" checksum="ADB0CE913A25247D" modified="2022-01-19" version="1">MKLSRSLALSFPPIPPFRSSSLVLDLLVWWVSWGFFIVDFNNSGGHWIMFPCFHFSCSCDCPSMAAQVTLTLKERLGRETPNLLPWSYWTLDLADTEASRDTRNRFPRLNSSQSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0L1</accession>
    <name>A0A8G1R0L1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_521042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514244.1">
        <property type="nucleotide sequence ID" value="XM_025665183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0L1"/>
    <dbReference type="GeneID" id="37168585"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034920935" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="9660" checksum="CB9AAB8E038C9A48" modified="2022-01-19" version="1">MVRLMALGLFLISALTAQACTYCQCEFSDSSHCCVYSDATIGELDCTSICAKAHRADGVSNADGTAGTACNAGGKYECISAITAQGRTPCYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R117</accession>
    <name>A0A8G1R117_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_449996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515195.1">
        <property type="nucleotide sequence ID" value="XM_025660282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R117"/>
    <dbReference type="GeneID" id="37163684"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="62" mass="6708" checksum="22D40115C7378BA8" modified="2022-01-19" version="1">MPRCFPKGIRPNDSLGRAWHYDLANEGSGSGGDQMANFSLSFCNVSIADPPILHEKIKVASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R188</accession>
    <name>A0A8G1R188_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Maleylacetoacetate isomerase maia</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_305464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Zeta family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515456.1">
        <property type="nucleotide sequence ID" value="XM_025655370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R188"/>
    <dbReference type="GeneID" id="37158772"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03191">
        <property type="entry name" value="GST_C_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03042">
        <property type="entry name" value="GST_N_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000010">
        <property type="entry name" value="Maleylacetoacetate isomerase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005955">
        <property type="entry name" value="GST_Zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034330">
        <property type="entry name" value="GST_Zeta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034333">
        <property type="entry name" value="GST_Zeta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01262">
        <property type="entry name" value="maiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="102"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH57534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="232" mass="25797" checksum="9CDE3C5997BDDAA9" modified="2022-01-19" version="1">MSEQTITLHTYFRSSCSARLRIALNLKSIPYTSIPINLLKNEHHSTQNTSLNPSASVPTLIIENPEHTNDGKTIIIPQSLAALEYLEETHPTAHPLLPPTSDPTARATVRTLANIIACDVQPVTNMRILKRVAPLGVDRETWSKDLVEDGFRAYEAIAKKTAGRYSVGDEITLADVCLLPAVWGAERVGVDLGDFPVIKGVRERLEEVEAVRRAHWRSQDDTPEEFRVGDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R198</accession>
    <name>A0A8G1R198_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_397684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515471.1">
        <property type="nucleotide sequence ID" value="XM_025657030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R198"/>
    <dbReference type="GeneID" id="37160432"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="2">
        <location>
            <begin position="120"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="235" mass="24438" checksum="4F7AA960E69F11AF" modified="2022-01-19" version="1">MADNKRHSVGARTSAQGSSGATAGQGMAGAMVPLEVALSRAIGARVRISTSPVASTIEGTLFTACPITNLVAINTAEEGKSQTGDYHVIPVSRIQSFQVLSLSPSNTDGASFSDAVPPLHALDIRALKAREAAAVGKLQEGEARRGKGVTKEAQDLFDAFSRTMPARWDGTKIIVADAVSIAAPYRPDDCRPLVAGDTAALARVRMVLEMERKKIELRNASATIGAGAAGQRKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1I7</accession>
    <name>A0A8G1R1I7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_421570</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515606.1">
        <property type="nucleotide sequence ID" value="XM_025657933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1I7"/>
    <dbReference type="GeneID" id="37161335"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF4">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="40"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="316"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH57684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="488" mass="54643" checksum="07E6AEE0025CB0ED" modified="2022-01-19" version="1">MPSTSDLADPKEYQKIFHWAETQKDGTIPSFATRRNDPYEYQAGFGNSFASEAVPGTLPQGQNSPRNVRFGLYAEQMTATAFIAPRHCNKKAWLYRARPAVAHQGFTDLPDNKDTESNFLPLNPRVHVSPTQLAWHPFDIPTNGEVDFVSGLKTVAGSGEPTLREGLATHVYTANTSMTKKAFVNSDGEMAIVPQQGALDIQTEFGPLFVQPGEIVIIQRGIRFRVELPDGPSRGYILEIWGSQFELPELGPLGANGLANARDFLYPTAKYEISKEPWEIVYKLGGKFFKSTQNHSPFDVVAWHGNYVPYKYDMTKFVNVGSISVDHMDPSIFCVLTAKSRDPTAPLADLLIFSPRWDVASHTYRPPYYHRNAASELMGLIYGDYGGRSDAFQPGSVSFECGMVPHGVAYEEFKAATEVDPPAMRISEASMAFMFESSRPFTITDYAWTSNKRHEHEPKMWDNLVDNFSKHEKEVEELLAKKAQGMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2P1</accession>
    <name>A0A8G1R2P1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-T/Histone H4 histone fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_397103</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516080.1">
        <property type="nucleotide sequence ID" value="XM_025657012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2P1"/>
    <dbReference type="GeneID" id="37160414"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="360"/>
            <end position="467"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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            <end position="59"/>
        </location>
    </feature>
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        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
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            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
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        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH58158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="468" mass="51213" checksum="934B5BC8F68584A7" modified="2022-01-19" version="1">MATTPKPRRRSPRVSDGSEALTPVGDTTLTGLQRLPAHTKYPLTPSRFASTTPSANRYTPRNRGAGAPSTPYRVQALQRRAANTPGRDRRRSGRIQRETTFDILRNLGKALAPTTQPIQSSPQEQVESSPEPEPERDEIEDLDNEPEIERPRLSLPLDEVEEVDEEPEMHPPRLSLAFEEEDITVEYPRRAMSEHDRNRLSMMSVGGPRMSEIGAATGLESESEDGDDTGIVHGDDGGEDTVLTQGDFEGGGETEDLGRFNFEFNFPSPPAPGAELDQEEPIHDDEGFELSMDMPMDTGAGSDDADSVSIAAGDFGMELQSPPPAPVALSESQSPGIAGGGLRDEDRYVSGAKQKKLSRHGIPVPNLPVGVVKKLATRFARARNGSKAKISKETLAAIEQASSWYFEQASEDLAAYSKHAGRKTIDESDVATLMRRQRHVNQSTTIFSLAQKHLPKELLQDMRLAMPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R2Q8</accession>
    <name>A0A8G1R2Q8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_477923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025662862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R2Q8"/>
    <dbReference type="GeneID" id="37166264"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH57432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="193" mass="21679" checksum="C405AD4739E42980" modified="2022-01-19" version="1">MTREYPCDIKPSTKPSPTHLSFNNPPSTTSPLIHSNSMKSSNKPRLYISLHARGGGVRPKMPDKEDTYHWSLTILPKDKQQHRFPKTKRSIVGTTYHVRELPTPTGTGMVFKWTFEERSTALDTMVLVRVLIGKVVDRERLVEILREVPVGGGEEEGGEEGWNCVSWVRGAVEAIKRDDENGNEVLGKGRGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R399</accession>
    <name>A0A8G1R399_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_448497</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="RAH58443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025659946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R399"/>
    <dbReference type="GeneID" id="37163348"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH58443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="286" mass="29758" checksum="A47BDAB2F35CEC35" modified="2022-01-19" version="1">MPNPKTILITGCSAHGIGAALALTLARQGHFIFATARNTSKIPERLSALENVQVLPLDVTDPASIAGAVSSVRDHGRGLDILVNNAGTGYTMPLLEADLDRAKAVYEANVWGLLGLIQACSDLLVAAKGRIVNMSSVGAVVNTPWIGIYSSSKAAVTQLSETLRLELSPLGVSVLCIMAGTITTDFHANEPEVVLLPTSRYAAIRQTISDWATGRAGPQGCSADEFANSIAGDVLGSSSANGGLAWKGPNSAAVKFMARWCPGGLLDRMMSNGQGLDELAKATNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3A5</accession>
    <name>A0A8G1R3A5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_449700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH56970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514892.1">
        <property type="nucleotide sequence ID" value="XM_025660209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3A5"/>
    <dbReference type="GeneID" id="37163611"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH56970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14390" checksum="89688C567F52F45E" modified="2022-01-19" version="1">MSGSKSPIEETEKSLVQKARAWGENSFPPTLLATLITAQYMRPFQALPMLFPPVLIFTSYANIQGFKTDTAGISAAWSGLYLLLAGRRKQPFMKKWGARGIVRGATMGLCLVNMVSGGLAYTLGKREEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R477</accession>
    <name>A0A8G1R477_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_374426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514452.1">
        <property type="nucleotide sequence ID" value="XM_025656128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R477"/>
    <dbReference type="GeneID" id="37159530"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026093">
        <property type="entry name" value="MGARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22910">
        <property type="entry name" value="PROTEIN MGARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22910:SF6">
        <property type="entry name" value="PROTEIN MGARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="150"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH56530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="639" mass="69750" checksum="FA93045FA405A485" modified="2022-01-19" version="1">MAEDTPAASAPAPDAGESSVERAPADAQPAVAESAQEPSKEKEEQQTNGPEDKPSATETATEEEKKEPASAEAEESSAPAESADAKKSDESAAAPAEPEAAPASEANGTPASAKKSGAAKRKSTGTVPEHKSKLSRKKSQIRTTHLNAQPGEYYLARLRSFPPWPSIICDEEMLPQTLLNTRPVTAQRPDGTYREDYADGGKRAHERTFPVMFFETNEFAWIPNTDLTPIDAAGCKEVSEKGKSKTLLAAYAVGAEGHDLQHFKDLLADHQRALEQEIEEREAQAAAKAAAKAEREAKKNKRKSMDVVDDEDVDMDDADEETKKPKSTKKRKKDNDSEAQSEEKTPKTTTKLKLTTPKTPASESGKKAPASKGKQTASSKKAAKAAASDDGEESRAESKEPEKKLTQEEAKDKKEKEILFIRHKLQKGFISRDQPPKEEEMTQMSNFFGKLEKHADLEVSIIRATKINKVLKMIVKLSSIPRDEEFQFRARAMSILSKWKNLLDADATGPSDDKEKGDKPKANGVHKESSVETPAKGDTENEKEDDTKESKADTAEPQDEPMPDADAAEKPQAPEPATEETEKEAPKTEEATTEKAAEEKSSEEKPTEGKATEEKADAEKTEEKADNEKTEEKPVETAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4F1</accession>
    <name>A0A8G1R4F1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_469350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514557.1">
        <property type="nucleotide sequence ID" value="XM_025662327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4F1"/>
    <dbReference type="GeneID" id="37165729"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="328" mass="38531" checksum="326393A28683F46B" modified="2022-01-19" version="1">MKSFVFFPQLPWEIRDAIWRLCLPSPQIVEFDRPICDNEPCRRFCGVHHGYHLRLLALAAVCQESRLLLLREYYNPEADAEIPRGMGAYLWNDEDNAIPYFCAVTRKAVHNPISITDRHLRQKFDEPFFAGSVRVAALDNFDFKDDAETLRSGLFGKFELDPVRYLDPNDSKTLQRYHQLWRTQNPTIITTCTTTGPAAPITPWTREIQQAAAAEFFALLEDDHQPLRDRLALWKEYIDRGWVWNVFYRMAEEAKARAPVSVPDRDVLFLPPYPGYDWQDDEETFDYFQSKYTLNRDNPWIQGVLDEMPVFQPMILFRHRMGIRCTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4S8</accession>
    <name>A0A8G1R4S8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_370475</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516588.1">
        <property type="nucleotide sequence ID" value="XM_025655960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4S8"/>
    <dbReference type="GeneID" id="37159362"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000015">
        <property type="entry name" value="IQ and HECT domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="853"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="700"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="706"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH58666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1229" mass="139742" checksum="628EA93AF69315FE" modified="2022-01-19" version="1">MFQSFTGNSRRPRQVNLGGRNTNPFAAYPSGRQNPHGAGPQNTLAIAQQERLARQQERERLTASRLVQRTWRGYRSRKITRRTWRTEWDIIEKKQGTDHLPSFDILAQQPDVVLQPSLRYGTAADCLSQLRLLVQFLEPWDSGDVARLVYFSEAFQRTLHEVPSIATEGEWTTPLKKLAGLTLRVLRSVTSPTVPVFAVQHLLQLLVFLTGLIPKHMARLAKEYYSVMVILTKDFESISTRYKLSRDSLTESVLALLRPITSETLTAYEWFAKIYLTIPNLPEYIGSLDGLANNINYKLLTSALGPLQTLFGDRPKSEEDVNARLWLLAYFIFFHRCALGGQTGRPAPEPGFVKVVSELLNSTAAHISRRLESEDSNDYDETPEQTPLHPFIKEQLVSLVNQSNITGLLSQLHTTHLSQGELANAQSDASKEAKILATYALTLLRVFPRRGDDIRMWLYLGSATSSDQLTGQQGSRIPAIKYFWQASKASRIFAAISQDSTKVLPLLKPAEESQGTRSSEISQMERDEEWTIILLFLELYTFVLKVMDDEEFFSSESSFTASSNTRVSWTKESALPLKDIKDMTIFLKNLGFTLYWNSADLSEKEATQDTGGIRSYFSSSAAPPDAIASVRDIEMKNKEKGLPGVTGIPLDYFKGLVTGLLRMIHERDSRRKFLPDGHWLMTSRFDMEGFIPAVVAEEENRHQLQDEDEEEEQDDLMNDSFFEPSPGLIGTGRAQQTRRIEALRRRQQQAARRKQLEAVAPRMEILRNMPFFIPFPTRVQIFREFIYRDQMRRRQGYIDPDAWRMSVAQASMGRLIDGRPAVQDILSRHHANIRRESIFKDAFDEFYELGDGLKEPIQITFIDKFNTTEAGIDGGGVTKEFLTSVTSEAFKSTSDLNLFEENDQHLLYPNPAAVEQRRELLRQLGFVENTAEWNENVRDLLRRYEFLGRIIGKCLYEGILVDVNFAPFFLLKWALTGGTGSAQRETAYRANLNDLKDLDQGLYQGLLQLKNYPGDVEDFSLNFTVTDTIPLPDGGNRTTTRDLKSHGSDIPVTNQNRLVYISYIARYRLQVQPALQTNAFLQGLGQIIQPSWLSMFNQTELQTLVSGDSGDIDVADLRRNTLYGGVYTIGDDKEEHPTVKLFWDVMEKMSNEERQKVLRFVTSTPRAPLLGFSHLNPRFSIRDSSEDQERLPSTSTCVNLLKLPRYTNANILREKLLYAVNSGAGFDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R581</accession>
    <name>A0A8G1R581_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extracelular serine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_447922</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH58891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516813.1">
        <property type="nucleotide sequence ID" value="XM_025659812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R581"/>
    <dbReference type="GeneID" id="37163214"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000251">
        <property type="entry name" value="Extracelular serine carboxypeptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034384574" evidence="6">
        <location>
            <begin position="18"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH58891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="569" mass="62825" checksum="EF4CE64493CCE885" modified="2022-01-19" version="1">MFLSLPLLGTLIASTVALDSSPLELRTPHLHQLSQLSKSHQASPNQESASFPVYNLSVPIDHFHNESRYEPHTNATFGLRYWLDTSHYQPGGPVFVIAAGETDGSDRIPFLSQGVVTQLAAAYNGVALILEHRYYGESYPFANLTTENIRFLTTEQALADYAYFASNIVFPGLEHLDLTAATTPWIAYGGSYAGAFVAFLRKLYPDLYWGAVSSSGVTEAIIDYWEYYEPIRLYGPSQCISTLQTSIDIVDRILIDHANNKTLAQQLKSAFGGSATNLGNQDFVSSLSYGLDSFQSRNWDKSIGTPLFRAFCNNITNSDVLYPETAEPISALVKQLVQIAGYDSSNTTLINNFLNWIGFLSTSKVFTDSSSESSSSSVTNSTVPQPLTKDSGTSWNYQVCVEWGYFTTGSSVPSNIKPLISRLLDLPYLSSFCPNTFGIKTPPDVQRINQFGGFNFSYPRVAIIGGLADPWRDSTPLADGVDWQSRKSTDSEPIILLDIPAADVWDGVRGAVHHWDQNGLSAEQEKDGEKAPKEIVSVHKEVVRFVGVWLNEWKGKSSDVDENIYQTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5D4</accession>
    <name>A0A8G1R5D4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial division protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_486330</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517800.1">
        <property type="nucleotide sequence ID" value="XM_025663383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5D4"/>
    <dbReference type="GeneID" id="37166785"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="15">
        <location>
            <begin position="128"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="323"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="363"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="404"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="444"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="484"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="524"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="597"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="614"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH59878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="657" mass="72247" checksum="5950AE63A78249DF" modified="2022-01-19" version="1">MSPRSVPEQLATAPSKSSAARDSVASLSSAHSRSLSSSTKTGTPIPPNLLPSAPASPPTPAPSPTPHQRPPTWQTPDEEDDAFLLNARIHFSSLSNARKQKFLEGILGLCDSQHLSFVSSYVSPRLRKDPFQVFPNELCLRVLSFIDDPKTLARSSQVSKRWRELLNDDITWKNLCEKHSYASRRLSEDDRDFVDPFHGQPLHAVSSTQSLSGLQRRPPVATLQPREGLPDVSSRSLSGDWLSLSGYPSRKRRVRPLSYRSHFKQKYMVESAWNKGGRCTQRHITPDQGVVTSLHLTPKYIVVALDNAKIHVYDTNGDNQRTLQGHVMGVWAMVPWDDILVSGGCDREVRVWNMATGACLYLLRGHTSTVRCLKMSDKNTAISGSRDTTLRIWDLASGTCKNVLVGHQASVRCLAIHGDLVVSGSYDTTARIWSISEGRCLRTLSGHFSQIYAIAFDGRRIATGSLDTSVRIWDPHSGQCHAILQGHTSLVGQLQMRGDTLVTGGSDGSVRVWSLTKMAPIHRLAAHDNSVTSLQFDSSRIVSGGSDGRVKVWSLQTGQLLRELSTPAEAVWRVAFEEEKAVIMASRAGRTVMEVWTFSPPPEEDGDDAVIVESASSTPGLRPTSNDSRHRERYSDPPPSVPLNSDDDQAMVDAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6C6</accession>
    <name>A0A8G1R6C6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBX domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_391506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518030.1">
        <property type="nucleotide sequence ID" value="XM_025656812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6C6"/>
    <dbReference type="GeneID" id="37160214"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="406"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH60108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="514" mass="57918" checksum="3AE7A59288325613" modified="2022-01-19" version="1">MSTSGLDISQLSDSERSALETYTAVTGQEHSEAIPLLRRSQWNVQIAISKFFDGEGPDPVEEARAALNSPPPRPARQTQNLMSDDIAAQFTPTPRAAEPAPRINTQPEDQSVYRPPFILALLFTPLNLLYRLLYSSFRLFGALFPFLPRFFNTTANPALQGSRRNTNGRRPLGPKDTAARFIREFEEEYGTNSISFLENGYNMALEKAHRDLKFLLVVLLAPEHDDTNGWVRDTLLSREVTDFVNDPQNNLLVWGGNVQDSEAYQVANSLRCTKFPFAAALVHTPNVSSNAMSVVSRISGTTSPAEFVEKLRSAISQHKEPLERIRSTRAEQQASRSLREQQDSAYERSLAIDRERARQRREAEAARQREEQEAAERQAAEEKRIQDLQQWKQWRAQTIPEEPGPDVKDAVRISIRLPSGERVIRKFAPDASLDELYAFVECYDILKEPTEKAAEAVKPEGFEHQYGFRLVSPMPRVVYEVEAGGSVRDKIGRGGNLLVEPIDDGSDEESEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7B3</accession>
    <name>A0A8G1R7B3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_466287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518756.1">
        <property type="nucleotide sequence ID" value="XM_025662122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7B3"/>
    <dbReference type="GeneID" id="37165524"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47542">
        <property type="entry name" value="ACYL-COA N-ACYLTRANSFERASES (NAT) SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47542:SF2">
        <property type="entry name" value="ACYL-COA N-ACYLTRANSFERASES (NAT) SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="236" mass="26774" checksum="9A7A9BA8DE8E2B10" modified="2022-01-19" version="1">MPPADLTPSLTISDIHSLKRDQALEILAQISRVEKKTFPANEAFSFGEELWRKKPNTRVLYVTRAPSAPGDVRPTLLAYAVYVRQKGIALLHKVCVGEAHRRQGVAMRLMNYIRARLQSEGCQQIQLWVDKARSPARSLYVRNGFKERDQIPDYYAPGPVAWALPDPPTPPLYAVDRSHKTSPWYFLFKTRVALPVKYSPLSLREIRTLLRGRGWAGYAPVWTPASHPLQARAFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7N3</accession>
    <name>A0A8G1R7N3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Alpha-1,6 mannosyltransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_465560</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519523.1">
        <property type="nucleotide sequence ID" value="XM_025662065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7N3"/>
    <dbReference type="GeneID" id="37165467"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF6">
        <property type="entry name" value="MANNAN POLYMERASE COMPLEXES SUBUNIT MNN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="42"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="154"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="251"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="431"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="566"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH61601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="764" mass="85268" checksum="89E7D2724FAA0756" modified="2022-01-19" version="1">MSSTSAPLATATTSGTPEQRSSGNMTEADTPKHSPPKPQSSKHDYKGFVAGVFSGIAKLSVGHPFDTIKVRLQTSHDGHFRGPLDCVLQTVRKEGVSGLYKGATPPLVGWMVMDSVMLGSLTLYRRLLLENVFSKPEFRASMPFIGKQTDLHTLPSFGHGIAGIMAGTTVSFIAAPVEHVKARLQIQYSADKSKRLYSGPIDCVRKMLRTHGIAGLYRGLCATMVFRSFFFFWWGSYDVLTRLMKEKTSLSAPAINFWAGGISAQIFWITSYPSDVVKQRLMTDPMGGALGDGQRKFQWWKDAAVAVYRERGWRGYWRGFVPCFLRAFPANAMALVAFEGVMRWLPSIPPSPPYPIAHLNNHHHHHHLELRTCYFSLDQQTATMAVARSMRRTSPITVFLAALLAFGFLCFLLSPSSSAAAAAPVTDSSSQLRREDAAEHPLSPPTKPFLKSQAVREDGQKAPPPVMHYNLNELSSTSESIKKGERVLILTPLARFYQEFWDNVVKLSYPHEFISIGFIVPKTKDGDAAVTALEQAISETQSGPVDSRFASISILRQDFDPPIQSQDEKERHKMSNQKARRESMSRARNSLLFTTLGPSTSWVLWLDSDIVETPATLIQDLTAHNRPVIVPNCFQRYYNKDTKKMDVRPYDFNSWIDSSTAEELAGMMGPDEILLEGYAEMPTYRTLMAYMANTGAPRPSREMELDGVGGTALLVKADVHRDGAMFPAFPFYHLVETEGFAKMAKRLGYSVYGLPDYFVYHYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R856</accession>
    <name>A0A8G1R856_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,3-dihydroxybenzoic acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_256113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517921.1">
        <property type="nucleotide sequence ID" value="XM_025654981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R856"/>
    <dbReference type="GeneID" id="37158383"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF31">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="38"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH59999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="354" mass="41303" checksum="E5B19A031AB87347" modified="2022-01-19" version="1">MRGKVALEEAFEVKGMDEEIDAQAALYIAPKDVERYKRQIVSITDERLQLSDQNGIGYTILSLTVPGIQGITEKDKAEKRARDVNNYIHDQIKDHRDRLGAFANLSMHDPRQAGHELRRCVKELGFHGALLNDVQHTGEGDDEQPLFYDQPDYDEFWRVAVELDVPVYLHPAAPLRDTQLYKQTYEDRKYLIGPPQSYCNGVALHLMGIIVNGVFDRFPNLKMIIGHMGERIPFDFWRMDHWVKGVTRPLAEKNGDTVCQKEPLYYFRRNIYITTSGNFSTQNLRYLYEWLGDERMMFSVDFPYERMEHGCQWYDDEEEKIKEALGGRDGYLRVGRDNARRLFKLSKFKDCDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8B6</accession>
    <name>A0A8G1R8B6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_228595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518403.1">
        <property type="nucleotide sequence ID" value="XM_025654762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8B6"/>
    <dbReference type="GeneID" id="37158164"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH60481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="185" mass="18998" checksum="2CC8B70D99B244E6" modified="2022-01-19" version="1">MCIRYYIRANDHKIINKILPARQQSILAGHYHALLEGLHSSAAASASASLGTSPALALLAAAAGALVFAVSSGASSASSSPSGASSSSSSTPFSSSPFSASPFSLPSSSSSSCSGTGAVFRFLEAGGAARRRLVPLVPLRPPLLLQAPLLRFPLPLLPRSRLLRSPHICSSITSAIVSIKCKGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R8U0</accession>
    <name>A0A8G1R8U0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_193000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519214.1">
        <property type="nucleotide sequence ID" value="XM_025654448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R8U0"/>
    <dbReference type="GeneID" id="37157850"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR GRISEA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH61292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="538" mass="58442" checksum="B07E6ABEE3B18DAD" modified="2022-01-19" version="1">MPLDEEGAKWSCEPCIRGHRSSKCQHFDRMMMKVPKAGRPLARCPHPKGTCSCQKLYAFMIRIPKGSTCLCRPVYQVPADAAESASTTPISAPPMPIAAPNKIQKPIKRQIKTAPENLTKALNSIPEFGSQQLEHGNFGRPSPYSAQEQRLCSSYDIIKQEPSPSHKTFECASEEKAPQGGSCCSRKSQPSQIIIPDVPAPAVQRSCCRKSDSAAQDVEKEDSTPSGYDHFQPPAFDSDNARYTPNSIPQVSTWQDFQAAKQSQYMQPFALPISESGYLPMAGPAAGFHSRPPDFQHPHAFNNYEIFNNQISQPTSEDTQNAIADPANPAGEASHDCSCGDGCQCLGCASHPFNNTTRQHVQQMGLLVAFNDDEQSPNRLNSHRGSPSQSQPPDFSSLQYSFANFGNPLGDNFHPVAMHSYAQQSADSGHANNGYSSPPADYLGQQLMVPSEYYTLEYPVGLPSACSDTTGSCQCGSDCTCVGCLTHSGHNGLPLEPAMPEGNWDHMNLPGFSMDATGHSTSQMPVMDNFVAHSNSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R912</accession>
    <name>A0A8G1R912_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_465660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519671.1">
        <property type="nucleotide sequence ID" value="XM_025662074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R912"/>
    <dbReference type="GeneID" id="37165476"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="8">
        <location>
            <begin position="19"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH61749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="449" mass="49971" checksum="4E2CCB14BA951C73" modified="2022-01-19" version="1">MDTYKDTFQLPRIKGQPLHVLIVGAGIAGLSAALAIHKTGHKVTILERVREIAEVGAGIQMAPNAARILGRLGLLEKVMEKANVLEMNSLRRYKNDEELGKAELMPSVGEKYHAPLAVIHRGDLQSILLEAVRSENIPIRTDSRVVCAAPDFSARVQLHTGEWVSGDVVIGADGIKSDLRHQMAAQHGVQDICQPTGDAAYRIQIPEDKMKGDPRARELLKKNVGMRWMGPGGHIMAYPMKNNTVYNMVLLHPQKEGAETEESWTNKGDKREMEEFYSEWNGLVRSLLSYVPDGEVMEWTLNSHFPLPTWIENRVVLMGDACHPMLPYVAQGAAQAIEDAGVLGCVLALTDDIDSALAVYERVRKDRAEQIQKSAAVTRKALHLPDGEEQRKRDEAIRGPGKNPDLWADKSWQDFMWGTDVMKETVDNFDDLVARSHGYHPHALNAVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9C3</accession>
    <name>A0A8G1R9C3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_486758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517062.1">
        <property type="nucleotide sequence ID" value="XM_025663403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9C3"/>
    <dbReference type="GeneID" id="37166805"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="424" mass="46001" checksum="2439B5FF6ABBF378" modified="2022-01-19" version="1">MGRTVDQEVHAAFVEFRAKEDDKCLSVQCIYCQQIRAKNTSRQKQHLLECPGLRGHTNPQAQSQSAPSAPNGIAAANGYPPTPNGAAATAPGAAPGPGALATPNGPMMSNGVNPHATPMQTPLQNMQSRASLPTSGPAGTASTVSATQQAARATPKAKPKNSTSNLPAPPLDDVHAAFVEFRAKEEDKVSEDMVRVLPDRTLCLTGDPHQCLSVQCIYCQQVRAKNTSRQRQHLLECPTYLSVMKDSIPANNLLHTFPEGDVARSLQIPAPTLELDFRMSIKMNPKVSVGESIWGQRDWVTFVGGQWAGRWGKGVVLPGGQDSQVVTKESSTHLRASYMLQTADDPPAYIVVKTNGWLTGAKDILDKVNDPGMADSINPNTYKYRINLNMETGDERYAFLNTLMWIGSGCRRGHEVIFDAFRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9L8</accession>
    <name>A0A8G1R9L8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane ATPase</fullName>
            <ecNumber evidence="10">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_454745</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520558.1">
        <property type="nucleotide sequence ID" value="XM_025661343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9L8"/>
    <dbReference type="GeneID" id="37164745"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000021">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000030">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="766"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="793"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="829"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="893"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="944"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="96"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="258"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH62636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1019" mass="112738" checksum="C082B7955E5B8087" modified="2022-01-19" version="1">MAEQAGASGDVERVAQTTQSQIRTSTSERRDSRRVSRVSYKEDYANLDEYGKLVKYASTYREGRPGDEVQGEEEEKRVWYAPWKKRKVFVKHIDQQPGQFPEEWLITDIRQGLPSSEVPVRRRRAGWNELVSEKENPIAKILSYFRGPILYVMELAVLLAAGLDDWIDFGVIIGILCLNAAVGWYQEKQAADVVASLKGDIAMRATVIRDGQQQEILARELVPGDVIIIGEGSVVPADSKIICDVNDPNGWEEFKRMQEQGDLSSTSESDLEDNEPEGGQKEGEKEEDSKPRRRRGYPILACDHSAITGESLAVDRYMGGLIYYTTGCKRGKAYAVVQTGAKNSFVGKTASMVQSAKGAGHFEIVMDNIGTSLLVLVMAWILAAWIGGFYRHIPIASPGQQTLLHYTLALLIIGVPVGLPVVTTTTMAVGAAYLAKKKAIVQKLTAIESLAGVDILCSDKTGTLTANKLSIREPYVAEGVDVDWMFAVAVLASSHNIESLDPIDKVTILTLRQYPRAREILRRGWKTEKFVPFDPVSKRIVTVASCDGTRYTCTKGAPKAVLQLTNCSKSTSDHYKAKAQEFAHRGFRSLGVAVQKEGEDWTLLGMLPMFDPPREDTAQTINEAQNLGISVKMLTGDAIAIAKETCKMLALGTKVYNSDKLIHGGLSGAMAGDLVEKADGFAEVFPEHKYQVVQMLQDRGHLTAMTGDGVNDAPSLKKADCGIAVEGATEAAQSSSDIVFLEPGLSTIIDSIKVARQIFHRMKAYIQYRIALCLHLEIYLVTSMIILNESIRVELIVFLALFADLATVAVAYDNASFELRPVEWQLPKIWFISVLLGLLLALGTWVVRGTMFLPSGGIIQNWGSIQEVLFLEVALTENWLIFVTRGADTWPSIHLVTAILGVDVLATIFCLFGWFTNQDMPTNPGDSFVETTNGWTDIVTVVRIWGYSLGVEIVIALVYFMLNKFKWLDELGRHKRDKGDLKIENLLGHLARLTVEYEEPGKPKGRFFLATSKEEEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R9Y3</accession>
    <name>A0A8G1R9Y3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction protein pala</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_445249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519769.1">
        <property type="nucleotide sequence ID" value="XM_025659214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R9Y3"/>
    <dbReference type="GeneID" id="37162616"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09241">
        <property type="entry name" value="BRO1_ScRim20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09236">
        <property type="entry name" value="V_AnPalA_UmRIM20_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="4"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="741"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="755"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH61847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="831" mass="93382" checksum="B7B6543CE7C6E999" modified="2022-01-19" version="1">MASNILQVPFRRSHSVTLSNAITQYISSKYDQRPDMFAEDLLIIERLRNEAINVQEPHVSGVSRLVTYAAQLKWLGGKFPVDVGVEFPWYPAFGFNTSRPISQNNIRFELANVIFNLAALYSQLAFSVNRTTSDGLKQACNYFCQAAGVLTHLRSDILPDLRTSPPEDMDDMTLQSLEQLLLAQAQECFWQKAVKDGLKDASIARLAAKVSDFYAEAGDHAVKSNAISPEWIHHMTAKHHHFAAAAQYRQSLDCLEKRKYGEEVARLRDSEACVNEALKESRWINRTVLGDLQGLKTRVTEDLKRAEKDNDIIYLNPVPPKSELKLIDRASMVAAKAPSQVTDAISMLGENGPLGQPLFSKLVPYAVHIAASIYSDRRDRLINENIIGELENMTDKLRDLLSSLNLPGSLQALEKPLGLPPTLVSHAEEMRQQDGLNRLRKSLEDTAKVKANDRAVYNEGVELLAAEKAEDDASRRKFGTDRWSRASSEEAAPKLYTTSREIEGYFTSAQSSDNLVEQKLKDSAAVFRVLTGTNRDLEMYVPSSRWAALPPEVEREVSRLRGCMSEVSRLESRRKRQAQALKDKARADDISQALIKETARLEREFPMQAIQASQFEDLFEEQLHLYDTDLDMVTREQQDQDEIAARVQEANRAFTRAHTGDASTKERERALQELENGYLKYKEILSNIEVGRKFYNDLAKIVGRFRDDSKAFVHKRRMEASQLEGDISSAAAMASLNISRQPQLQPQPQPQPQPSYNAPAQIQQPSYNAPPAQVQQPSYTAPQAAPRPEPMTAPQPTRANARPPMTPGIWSPEMGIRFGGQWDPSKGVKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA27</accession>
    <name>A0A8G1RA27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribulokinase/uridine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_244024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517437.1">
        <property type="nucleotide sequence ID" value="XM_025654864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA27"/>
    <dbReference type="GeneID" id="37158266"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="238" mass="26533" checksum="CDC46D7C0AF5101C" modified="2022-01-19" version="1">MEAEYIRIADAIQQEARKNDKKRLLVAIAGIPGSGKTTTASAVAQQLRKAESQPSRIALISMDGFHLSRAALDVLPNREEAYIRRGAPWTFDAVRFVTFVQQLRQWADSTPFPSDGDSSSDAAVIYAPSFDHEAKDPVENGMAITSDASIIIIEGNYLLLNEEHWRDVSHLVDYRIFVDADLQEARGRVARRHVSAGIEKTLEDGFRRVDSNDYLNALHIQGKLIRPDMVVKSVTEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA45</accession>
    <name>A0A8G1RA45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine-threonine protein kinase 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_363771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STK19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520335.1">
        <property type="nucleotide sequence ID" value="XM_025655671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA45"/>
    <dbReference type="GeneID" id="37159073"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018865">
        <property type="entry name" value="STK19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15243">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15243:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10494">
        <property type="entry name" value="Stk19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="41300" checksum="8AEE2C15FCE71D6F" modified="2022-01-19" version="1">MPLRVTSAPVSGIRKNRKPATSRPRASPFAAHARRKPSAPSSSGISKISSEQDEYEQGPLSDLGPSRYIPETAPVTDVVEALQYIRNSMFEDLPRRAGMNSTRIAEVLNFRRSLPPLASVAHVHTLLEAPTKVEKEIMELVRAGRVRRLIVPGRGNDAAGLGDCLVLREEWDRLVLDSLALEAPLKEKFLTLLGRIGNTCAIPGAAFTPPECMALVRAGFLVSSSSLAKGSSSLASLPILPTTSTTPASASRSGSYPPHEVGANPRSSSTTATLFLSLPNTGPYLRLLSAGRSHLLSLLKRSSSNEVPVYLLRDRWDGAVESEKSFSVAKRVRGEFSGILPGRTKKYKDLYGMNFRWALEEALGAGLVEIFDTGSVGPGVRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RA46</accession>
    <name>A0A8G1RA46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial DNA replication protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_366125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518582.1">
        <property type="nucleotide sequence ID" value="XM_025655766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RA46"/>
    <dbReference type="GeneID" id="37159168"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005371">
        <property type="term" value="F:tricarboxylate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015742">
        <property type="term" value="P:alpha-ketoglutarate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000078">
        <property type="entry name" value="Mitochondrial DNA replication protein YHM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="116"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="217"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH60660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="309" mass="33568" checksum="4F09AD6FD075318D" modified="2022-01-19" version="1">MSQAVATNTPTLQGNAEQKRPIPYRNLAVGALMNIFQVTSLGQPLEVIKTHLAANRQDTLRDALQKTWSRGRFLAFYQGLIPWAWLEASTKGAILIVTSSEIEYQARTKLNASPTICGALGGIGGGVAQSYLTMGMTTCMKTVEVTRSKMSVGGARVPGALEMFFQIIREKGIRGVNKGVNAVALRQVTGWSSRIGISRFAEESIRKVNGKPKDEKLQFGEKILASTIGGALSCWNQPFEVLRVEMQSMKNDPSRPASPTILSTFKYILATTGVKGLFRGVVPRIGVAAWATICMVGFGDTVKEIVNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAE2</accession>
    <name>A0A8G1RAE2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_360975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520466.1">
        <property type="nucleotide sequence ID" value="XM_025655574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAE2"/>
    <dbReference type="GeneID" id="37158976"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067:SF1">
        <property type="entry name" value="MITOTIC APPARATUS PROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067">
        <property type="entry name" value="YALI0C15378P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58022">
        <property type="entry name" value="XRCC4, C-terminal oligomerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="309" mass="34232" checksum="E99139E8EB7C7BB4" modified="2022-01-19" version="1">MSTSEHTSPPRVLRVPRSDEPDSYVLLHVARTNTAALDLNLTATEGEFPYNGVVRQARAKTHRSKGYQGTDEDWVLILLRALGQLEINTDNSDLLSGIELSASIKGQALKQDDEQAIQLFDWSAIAVARADMLEQQLLKLQRHYHEADSTIEQLNKQIEDFISAKRRHEEQLMTNFTQVLNQKKLKIRNQQRLLASAKIDVDDAGKHQAASSKVGARVGSKKHAKRPIVETSDDDAESDNGSESLDQTKPQTSPGRISDTDDEPNSTPQPLEDVDDTTDEDSPTASGIDQGHQQDNAEETAGETDDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAY3</accession>
    <name>A0A8G1RAY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_515833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521233.1">
        <property type="nucleotide sequence ID" value="XM_025664813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAY3"/>
    <dbReference type="GeneID" id="37168215"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH63311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="93" mass="10667" checksum="2E4E57EC99271819" modified="2022-01-19" version="1">MNVSASPSGSQPFIKRPTLSPAFKKPSRWYLPLMGAIALGFGVANYYENQARQPQFDREEEERLRKNRALMDAYGDKETVQDIERALVVYDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RAY8</accession>
    <name>A0A8G1RAY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_386490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520751.1">
        <property type="nucleotide sequence ID" value="XM_025656634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RAY8"/>
    <dbReference type="GeneID" id="37160036"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="607" mass="65749" checksum="61AA77BF04411B22" modified="2022-01-19" version="1">MAADQLLQSIAHSTPGEEWFDFDNSFDIPYGGVGSNPTSVDSVSPKDLDLTFADFDDCNWGPSPGVCTQELFADLVNYDAPMEGFGGHALDASPSMLDPTGSLHQMPASPTPGLMGSELTDLWSQDMGGVDDPFYTTVRQMVEFQAAADPSALSSKEKRMEASIALHMQRLQEAAMQDLELSSDSSTTFPSPRWSDSAASVYQGGTCTTPATTPLPDVTRTPVSSSESAAGAMELVLDLNMNTTTNVPKKQKPRSQAQKENYIKVRKHGACEKHRKQHKRCNCLEKAASQIAVSQKAVSTCNIPIKSTFSTQRHVHRSERESLLVSTTPTPASKSTVSQPTGGLGSKELQYVQLRHRHRLPSTPTSMDPQYGQHSPHSVKSAASCRGDVDLNGGTGRPTTLRDSSGQQQSPRSPGSDRRVGLVHSLSKRLQICSTSGQVDRGGLALRHAPDRQQANQAVTARMHVSVQASIPSRSSTAAVSGVLCRPSPSSRAAATASVQSNRGTEASAIFETHASSWRIRSLVYPSTPHSLAVQANDVHDQFASRTIVSRVLQSVFPVSHFLDLSVCFASWLSTCFDKTWSFSRFGKLVMISTRRHWLTGKGFRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB16</accession>
    <name>A0A8G1RB16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_482765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520815.1">
        <property type="nucleotide sequence ID" value="XM_025663123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RB16"/>
    <dbReference type="GeneID" id="37166525"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH62893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="525" mass="57286" checksum="CCF45480B9CB089B" modified="2022-01-19" version="1">MESLPKGLLTTATKVSTELDGVGPVNIGDVVQLWKVYSANPSAHDDDVGYRLENFFWRIWGSRCLNHTLLGTTLASLFLRISEPNPFSLVQLSKATKAAQAAQSSKGNHEGGSGRPAGNNGKAPLHPILKKPRNGSSSGETHKTTRLLLTDIDGQSTTRKPSNPPTPVPPSVPTMGDTAPRQTQKKAVFVASKAKSSKRRPVIMRRKSSQQSSGTSSTLAHSPPPDSPQLTLEYTPTPPIQELGSASNTTIGACELDGTEPLSRSHSDFRPDLAVSPRDTKTELPGKGLFAKDILEKGSVQGEKAQVERPPELPELFLSDLRELLDTDRPEEAHVKPPPPRRRAFYAVEPSLPEPNFFSATGCRRYDARYLSAENYEQPSSMKLVDKNFRKRFSDRVRQEQVLVSSLGTPGPETEPKTTPPKPVRAESSSTVTNATPSPSRFGDSHGKASTAPSSAVPFQRLSNHDDSFATDSQGSTDEEVSPVLTNFSMPRRQSQLSVMIEQSRQHGGEEDQQETEEVIEEIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RB85</accession>
    <name>A0A8G1RB85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_435107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520444.1">
        <property type="nucleotide sequence ID" value="XM_025658502.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37161904"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1799"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1956"/>
            <end position="1974"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1986"/>
            <end position="2004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2011"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1912"/>
            <end position="1937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH62522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2236" mass="247414" checksum="4A943FA51F7560C8" modified="2022-01-19" version="1">MSNNKESSHAAETPVSAHDAQGPGVTPGLGSPGVQRIEALSSHLHILDRVFLFCGDFLIAYVYGLDSLLRGTYQPYATASYGSHSTIVEASSSTVEQFAAGAVLYQIGYTAIILLVEVLVADVTSLRSRLLFSYIPTLPFLINTWISGNITGAVLKVTTWRWGIGMFAIIYPICTLPLLMVLYIVYHRAKKDGTVDHIAGAFRTLGVRRLAIELFWQLDVIGIILMIAFLAMILVPLTIAGGLDSQWKKARIIVPLVLGLCCIPAWVIWERTCKHPMVPFKLLKDRAVWGALGIAVMLNTAWALQSEYLYTVLIVSFGESITSATRIRSLYSFASVLTGSILGLVVYKVRRLKPFIVGGTLLFMVAYGILIYYRGGPASSSHSGIIGAQILLGIAGGLFPYPAQASIQAATKHEHLAVVTGLFLACYNIGTAIGGSISGAVWTQVLPGELNSRLGNATMATQAYKDPFTFSATYPIGTPDRDAVVAAYKHTQRLLCITGICLTMPLVAFSLCTRNLVRDSICFRSNIGYSLIMSSDFDAIWEDLLADLKTLPAISFDGFARRIHFRARWNSDFNSLRKYIGTDQPYPAGDESHNQELDGMDTGSEFSRLGNWFLTAEFMSIDDDGYWQEYLAMQLFPFIIYPIFTPEVLRGLMSMCLAEHLNSKFKSNGHPSLMELANTTGFADYFINRIQTKSFIINLALTDPTRSDHLFSISTLLVADYLYYKTAWLDIFKLLSKERPSFKALHAWSLVTWNEQERGDGVKTDNIVKNCGIAATMAYCSVLGSLSTFDALNFFYKAVIAAIDTDSFPELRPYLDSIQASLKRLIDEAAIINEFVSYSEKLYTTFYHNMSENWRDGTGSTRVRLAHPVLLLCGHYGLRNLSPLIPVELQSSLLSGTNLNLSQSESKQIEAVANNNRFLVSTKPPRYSHEGYGTVASKSLKVCSVGFNGEKPFTTPSQVFYTTTGLRAVDPGSAKASCPHAHIGPLRRGHVIYRLAGNPDDYKYEAVEISSIEVGPETEQNVYSVSLWAGEQSHHANGYLLAINDPNRAVEAAARALRAFPPKKRISLLVSFHELSSTFTKNDIQAIHERLNFELFGSYGKREEGLISRSEIFPALVSPSDQLKAMKYNPRQLPNGVPLDMIQRRFSLLAIGDSNLPSAYTLPDLSVIDDCILINDVPQMRCKVNHHRRTFQWTRRVQENMFEHGVLSLYSHGLSGKGVVLISPTDAPEDCSKKDVQAFEALPKSVAKNIQLLHAKRQAGEPESDDEGEYIPVITVSMQYDKNTWAPDEPIDEPKDPMSGMDVQWGFLYPPDGSQTTETRVPILDELRDRLNEKYNREFERLYDSWEVILDDGRTRATVEFNLASVVPFISDAGMDVNTLNVNFKSQLGIDITLPILFQSFYIDYDVDLRTVKGAIFDYNPLMRDTKGDRHYICGTSDIDDSEIYDMRLKTSRAFADCANLTAPTSFTSALHPAEVTEQLHLLQEPTVDELLNPYGYDEVAREDVTGQAKPTNLDSSLAENLPSDLQKFFREKYAPAFLCQSVMRYEKYEDKFTEQEKKNMRYWWDGNGDKCLAKSKEYAEINRRASVEAVRQFNKDILDKYLDDNPTEWACTLYAALKDKGRMLTYLAHPIQGSVNVINRECCILDALAPSEGIADQWFEYFVGFASERHIHYPYIDPDEDLAGQWLHDSMKDLIQRVLEGDPSVDEDVRKGLEKDIEEFEKANGLDQTATAEARASNIVEKGAVFFAEAKKWLTAVGKGLAVALQGTRLFQLAEASFEQVTKAIGDSLPGLKKLKPIATIGMVAFYVFQLASSLYGLITDWDTMEDAKKAVVILEMIQTVVNGIGQARDAWNNYKNRDTATTPEDALDTATLNQGVEKSVSESGGGLAEMSDEINGEGTFNEIVSDHLLPEGPATEGDNAGRWNEGADKPPENIPAGGEDVVSKWNVSGNAVKIINAFLGIGLVIAMTFSLVQDWDKLTTGGKIINTIALLSQTLTVVLDIVEVGSSIGLYTVTGVFATALPILGAVLAVLGVVMMLINLFVNLFGGSPPPDPVHEFIDHVAKCLVGGFEKAPPPKLDYTISSVTYESGKVTGITIKGENTTADEISIPNARIIVTSGSDDVCLFSTSEFELVEDSDPDKDSDGHLYVTPNSKAEGTLSSSVLGDETEYHEYDLVVGGNKKDTENSLHKLILQAKESFTAVWTGKINKSGRSLVEIIEKSDLDKCHVQYTVLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RC38</accession>
    <name>A0A8G1RC38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_466162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520383.1">
        <property type="nucleotide sequence ID" value="XM_025662113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RC38"/>
    <dbReference type="GeneID" id="37165515"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH62461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="504" mass="53381" checksum="45CFCDA41F4ECE20" modified="2022-01-19" version="1">MSLLREAEKCLANQGSHAALNALITTLHQSGQWLERVRDADARRTRGTPKSEVDGLLVAVKDNICTRDLPTTCASNALDKFVSPFNATVVQQLEDAGAVVAGKANLDEFGMGSHSIHSNFGPVKSSRRDLHAEYLSAGGSSGGSAVAVATAQCYAALGTDTGGSVRLPAAYTGTVGFKPSYGLVSRWGVVAYANSLDTVGVLGRDVASVRRVFGVVNQHDSRDPTNLSPSSRSRLDSHLRMPALASRTNSPLRIGVPVEYNISELSPSARHAWSRSLAHLQRQGHSIQTVSLPTTKLALSAYYVLAPAEASSNLAKYDGVRYGSRPEAPDGNASSESYLYAKTRGEGFGSEVKRRILLGAFSLSADAMDNYFIQAQRVRRLVQHDFNTAFRARQPLISSQLGSKSDSADASVDVLICPTAPSSPPRISSLIGPDATASPLEAYTNDVFTVPASLAGLPAISVPVTTESAGDAEDGDLAGIQVIGQYGDDELVLKVAEMLEGRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCD3</accession>
    <name>A0A8G1RCD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_476073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518622.1">
        <property type="nucleotide sequence ID" value="XM_025662757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCD3"/>
    <dbReference type="GeneID" id="37166159"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="103" mass="11593" checksum="4AB73AAE7D01161D" modified="2022-01-19" version="1">MQVAEILSDLTSLRVCDHHDALALVTVNERIPQPTDQLELKATDTTPSGSEVNPGRYGNDDLRRAKELVDLHYEFKARHALGTVDEELSRAREEVARVLRELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RCQ8</accession>
    <name>A0A8G1RCQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_7898</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="3"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520698.1">
        <property type="nucleotide sequence ID" value="XM_025665665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RCQ8"/>
    <dbReference type="GeneID" id="37169067"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815:SF13">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="13">
        <location>
            <begin position="52"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH62776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="167" mass="18058" checksum="8FF88CDC7FBCEF87" modified="2022-01-19" version="1">MALPQTQHQPQEQQQKTITQPSPQPTEMTPVTDTKTKMIKKITRHPTLPSHRRKIYLALLSVPAGRWTTYAALAKHIGTSPRAVGAAMRLNPFAPEVPCHRVLGGNGKLLVGYSGAEGSGGAKKKAKDGVGMKKRMLEEEGVEFTTEGMARGLCFEGFGMGSFAVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RDY2</accession>
    <name>A0A8G1RDY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_495356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521388.1">
        <property type="nucleotide sequence ID" value="XM_025663908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RDY2"/>
    <dbReference type="GeneID" id="37167310"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="LIPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18647">
        <property type="entry name" value="Fungal_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="641" mass="72698" checksum="F1A14A84E965C7FC" modified="2022-01-19" version="1">MIWLIFLLVILVTGSPDINTPPHDPPSSDLPITVLTFVRKWAAIGDSYTAGIGAGDVWSDKKEDTKCSRYDKSYVALLKHVLGPQVTNFTYTACSGARTSDIYTQAQDLDKLHDLIVLTGGGNDLCLSDIITTCIFLPFNSEEKCQKVIELAQENIKFILGYNVRRILEVAVSKVNAFGIIVWALYGQFFNTETDDCEKNQDWAFPGLAPFDALPLTRERREKLNQLVTDTNKVIKKTIDDYVMDKGKYFPRVHIRTADWNDFMKDGLKGQYCVPGSTGKYPDPMQPNLHFFKPDTTYERHTELKAKRDNITDTSFSSSADTNDTLSSFYDSNLYRSPNPAAAALYELNSTGVTLPPGCPGDDKGIGFGLPDRWGKYFHPNELGHKTIASFVLDGIYAARADFLGKRNPICSRGFEEFRCWQNDGRRDYASADLLNKNYKTYCKEVKPPKNTANWKDERWFHQLTPETHSFSIQLSDGATHFDQGHCMESFERIINSCDGNDPKNPMNWKFGGRWTRGSYTYEVNIANSFKRPWPPTREVGGFCDSSYKFWYQRYDMRGRGWATWDAGQDTLKPAIISCVGHGLTGWDFQYLDQPDSDGNEWVVKFNTPILTGPRCFDNNRVQFNAGGFTRGCHGVLRRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RE44</accession>
    <name>A0A8G1RE44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Xylulose kinase</fullName>
            <ecNumber evidence="11">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_444329</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="11"/>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH62999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520921.1">
        <property type="nucleotide sequence ID" value="XM_025658994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RE44"/>
    <dbReference type="GeneID" id="37162396"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07776">
        <property type="entry name" value="ASKHA_NBD_FGGY_SpXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000118">
        <property type="entry name" value="Xylulose kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042024">
        <property type="entry name" value="D-XK_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="12">
        <location>
            <begin position="133"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="13">
        <location>
            <begin position="297"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH62999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="569" mass="62633" checksum="8848DE2A5DEF7641" modified="2022-01-19" version="1">MQGPLYIGFDLSTQQLKGLVVNSDLKVVFVSKFDFDADSRGFPIKKGVLTNEAEHEVFAPVALWLQALDGVLDGLRKQGLDFSQIKGISGAGQQHGSVYWGENAEKLLKELDASKTLEEQLDGAFSHPFSPNWQDSSTQKECDEFDAALGGQSELALATGSKAHHRFTGPQIMRFQRKYPDVYKKTSRISLVSSFIASLFLGHIAPMDISDVCGMNLWNIKKGAYDEKLLQLCAGSSGVDDLKRKLGEVFEDGGIHLGPIDRYYVERYGFSPDCTIIPATGDNPATILALPLRASDAMVSLGTSTTFLMSTPSYKPDPATHFFNHPTTAGLYMFMLCYKNGGLARELVRDAVNEKLGEKPSTSWANFDKITLETPPMGQKADSDPMKLGLFFPRPEIVPNLRSGQWRFDYNPNDGSLQPSNGGWDTLDEARAIVESQMLSLRLRSRGLTQSPGEGIPAQPRRVYLVGGGSKNKAIAKVAGEILGGSEGVYKLEIGDNACALGAAYKAVWAMERAEGQTFEDLIGKRWHEEEFIEKIADGYQPGVFERYGQAVEGFEKMENEVLRQEGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1RFL6</accession>
    <name>A0A8G1RFL6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_435013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH62410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025520332.1">
        <property type="nucleotide sequence ID" value="XM_025658498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1RFL6"/>
    <dbReference type="GeneID" id="37161900"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF3">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G03960)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="119"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH62410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="243" mass="26155" checksum="9342BF15E92D1747" modified="2022-01-19" version="1">MSSSILDTPDPASLSPFLNATSPSLRSLLHHPDYLPVRTYSRIPKPSTGEDGYFANTLATARTIPHVLTLRRRPHLLSLLPNSPPTWPAPTGAPTPIEDPDLILILDIAAPGVSGHPSTAHGGVLATSLDEAMSYAVALYAPETGPKLVEDEQPDGPHVPPTPRGMLYTAQLDIRYKSPVAAPGYLVVRTKVLARVGRKFWVRAQAFQPQDTEGAVTSPKAEGEPMRLTTDAMAFWMQTGPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VG19</accession>
    <name>A0A8G1VG19_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO85DRAFT_239530</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825093">
        <property type="protein sequence ID" value="RAH51771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509693.1">
        <property type="nucleotide sequence ID" value="XM_025654822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VG19"/>
    <dbReference type="GeneID" id="37158224"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="BCS1 N-terminal" evidence="16">
        <location>
            <begin position="62"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="306"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="376"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="506"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAH51771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="600" mass="67190" checksum="A5314DDB39A3BB24" modified="2022-01-19" version="1">MASSAFLSNTINNTPIMNATSSSQYMNPSDSAMLDMFIPGYSFISRFLISYLHIDLSQYIPMILTAVAFVASLRYVFFRSHELLTNYCVSTAEIRLEDEVYNYLMFWMAQHPSTKKSTQFVASTKISSGARYYDSDDEGDGDDEDEYDENGNVVSDFDDYWAKTVARDKFKRLRFTPAEGSHYFWFRGRLLTFTRAKEENNNTISYMRYVPERLFISCFGRNPAILKELLAEAQRAWVARDGNSTVIYRGQKNGGYTDWVRCMARHPRPLSTVVLDQDQKQSFIKDIKEYLHPRTRRWYSNRGIPYRRGYLLHGPPGTGKTSLCFAASGLLGLPLYLLNLSSKSLDEDDLMSLFQDLPRRCIVLLEDIDCAGMTSKRAANSTQDDKNKSDPNNANANPAATPNAAANTPAGSSTDKKPSEETPDNKGITLSGLLNVIDGVAASEGRILIMTTNHPEKLDAALLRPGRVDMTIKFGYAHSQDIRELFSSIYSTLEGDLRSVSPNRRKNAITSHDGKGNGVKKTNIGDGMEDRPPVSDKIVRLAKEFAAGIPAGEFTAAEVQGYLLNYKDDPEAAIAGIGGWLERTEKTRKERKEKAEEGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHI3</accession>
    <name>A0A8G1VHI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-amino-3-carboxymuconate-6-semialdehyde decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_454152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825086">
        <property type="protein sequence ID" value="RAH52252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510174.1">
        <property type="nucleotide sequence ID" value="XM_025661212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHI3"/>
    <dbReference type="GeneID" id="37164614"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000055">
        <property type="entry name" value="Uracil-5-carboxylate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF28">
        <property type="entry name" value="ISO-OROTATE DECARBOXYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="6"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH52252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="383" mass="41891" checksum="40E4962F75ACB46D" modified="2022-01-19" version="1">MPPLIVDIHTHVYPPSYMHMLRARKTVPYVHDPADNATPRLIILSSDDDPSIPVDQRGRPVDSSYSDINVKLAFMRRHGINCSVISLANPWLDFLEPNEAQTWAERINDDLETTCARVNNDADPDKTKALHEKETLFAFGALPLSAPSPDIVVNEIRRLKTLPHLRGVIMGTTGLGKGLDDSRLDPVWEALQDTESMLFLHPHYGLPDEAFGGPEVTNRYGHVLPLALGFPLETTIAVTRMLLAGVFDRFPRLKILLAHSGGTLPFLAGRIESCILHERKFIANGGDVPGPQRSVWDVLSTNIYLDAVVYGTAGLKAAVAAAGGSDRLLFGTDHPFFPPLGKDDEEWPSVTTNYKAIHSAFESEGDTAAGVLGGNAARILDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VHU5</accession>
    <name>A0A8G1VHU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_503763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511628.1">
        <property type="nucleotide sequence ID" value="XM_025664252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VHU5"/>
    <dbReference type="GeneID" id="37167654"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="619" mass="66057" checksum="1C0D9649FE81A1E6" modified="2022-01-19" version="1">MPSFLPLWDKKSEGSPYNPESNTPTTSCPTEGQCATDENGSPASRPTPGYDLGSDGSQPLIQIEEAPPGAPATDNASAPPPTTTADLAQTQHDDAGGWPRTASLIDALPEVETNSPANEQTSDMGGTRSQLPTSVLSVSSKPSRPSLTQAAPPRIPYAGPGRPEGPGLFRSSTREESDYVQQFLINQVQAAQHPQIRHRRGAAVHNVDAGNLFGVPRRQVERTDSSALLTSESSTASESPSEDHPTTQARNTEGKDVSSLQGPQDESTVALDSGASSVYSATPLLQLDDTYVCENAAGNTSAPQAEQLNSPESQTTGASIAQDGSSLLQPLFKAKSTWPAFESTPAYSNDLSSLSMPFERSHSERLPGAYPSTDSPNSDEELGSTGNEPATKGPESTAKHGDLNASSSTPSHIQDTSKPSDPSPNAWYSTTEEGSNPYSFTVTWYAPESEFESRSQYFDAHSTLARSLPQSEPEPYAPLLGTAALSQTSPSSKESAESQETAEGASENQSSELDRGKSSAPTRNDDGLNIDESNRIECPRDEITLTNQVAESDDWSVDEGEDGMFCHPRDLMDHVERLQHHEQLCQSHRAAVRKVSLVTLLRLGLTPDYAALHPRTPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIL8</accession>
    <name>A0A8G1VIL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter Cdr4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_523435</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511717.1">
        <property type="nucleotide sequence ID" value="XM_025665351.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37168753"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000881">
        <property type="entry name" value="ABC multidrug transporter A-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="777"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1191"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1224"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1265"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1311"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1346"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1377"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1463"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="161"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="853"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="820"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH53795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1493" mass="166782" checksum="81794E854B0A08A0" modified="2022-01-19" version="1">MSSFVATTNPNSSRAQAVVSHNLPHMQGSPDLDNAVHGSPGSAYTEKSEQRSEDDETLQGKEEKIEARVGDLARQLTRQSTRFSTKGTLDNPFAVDDPESTLNPHSPNFKPKDWMKMLLAIRSRDPERYPDRTAGVAFRNLNVHGFGSPTDYQKDVLNSLLELGTLARRLVGMKMQKIQILREFDGLVKSGEMVVVLGRPGSGCSTFLKTIAGEMNGIEMSEDSVLNYQGIPAKEMQKSFRGEAIYNAETDVHFPQLSVGDTLKFAALARAPRNRLEGVNRHQYAEHMRDVVMAMLGLSHTINTRVGNDFIRGVSGGERKRVSIAEATLSQAPLQCWDNSTRGLDSANALEFCKNLNLMSKYSGTTACVAIYQASQSAYDVFDKVTVLYEGRQIYFGRTTEAKQFFVDMGFECPERQTTADFLTSLTSPSERLVRPGFENRVPRTPDEFAAAWKQSSARAALLREIEEFEQQYPIHGSSYDAFVDARKAMQSKNQRVKSPYTISVWEQISLCTVRGFQRLKGDSSLTVSALIGNFIIALIVASVFYNLPDTTASFYSRGALLFYAVLLNAFSSALEILTLYAQRPIVEKQARYAFYHPFTEAVASMLCDTPYKLINSITFNLPLYFMTNLRRTAGAWWTFWIFSVVTTYTMSMIFRTMASTSRSLSQALVPAALLILGMVIYTGFVIPTRNMLGWSRWMNYINPIAYSFESFMVNEFSGRHFTCSSIVPSGDGYDSISLDYRICSTVGSTAGSAIVDGTSYLKQSFEYTKGHEWRNIGILIAFMVFFCFVYLASTEYISEAKSKGEVLLFRRGHQPKLGEADMESSATPGGAVKGDAPAQGSEVRIQKQTAIFHWQDVCYDIKIKGEPRRILDHVDGWVKPGTCTALMGVSGAGKTTLLDVLATRVTMGVVTGEMLVDGRPRDQSFQRKTGYVQQQDLHLPTSTVREALRFSALLRQPAHVSREEKLDYVEEVIKLLGMEPYADAIVGVPGEGLNVEQRKRLTIGVELAAKPQLLLFLDEPTSGLDSQTSWSILDLIDTLTKHGQAILCTIHQPSAMLFQRFDRLLFLARGGKTIYFGEIGENSNTLSSYFERNGAHPLAEGENPAEWMLDVIGAAPGSHTDIDWPKVWRESPEHTKVKEHLAELKSTLSTKPEDNSDPEAFKEYAAGFGVQLYECLLRVFAQYYRTPSYIWSKTILCVLSALYIGFSFFHAPNSIQGMQNQMFSVFMLMTIFGNLCQQIMPHFVTQRSLYEVRERPSKTYSWQAFMTANIFVELPWNTLMAVLMFVCWYYPIGLYNNAKPTDSVNERAGLMFLLIWVFLLFTSTFAHMVIAGIELAETGGNIATLLFSLCLIFCGVLATPSNMPGFWIFMYRLSPFTYLVSAMLSAGLAGTTVTCEAVEYLSFNTPGNQTCQDYMSSYISANGGYLLNPSATSDCQFCTMSSTDTFLASVVSYFSDAWRNFGLMWVYIAFNIVAAVGIYWLARVPKGKMVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VIT9</accession>
    <name>A0A8G1VIT9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_452116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825071">
        <property type="protein sequence ID" value="RAH54696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512618.1">
        <property type="nucleotide sequence ID" value="XM_025660749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VIT9"/>
    <dbReference type="GeneID" id="37164151"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034712116" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="20231" checksum="707823DC00B1D395" modified="2022-01-19" version="1">MKFLSSITAFTILASVASTSPTPANLIPRACTTIAPTTIDVLDSANPNTPSTGQQFSLARTATANTKISALTFTGIPDDATGCMLAIDIPALAQPIATGSSQADIWTTDSWNLTSPPTWNNQPTRREMVSTFQFPTSPTTSPFHTILASNTCSNEMSFLALQSTWQTSPGSVDFQNSIGGSQPIGFSLVYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ07</accession>
    <name>A0A8G1VJ07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme E2-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_379789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512122.1">
        <property type="nucleotide sequence ID" value="XM_025656355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ07"/>
    <dbReference type="GeneID" id="37159757"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="46431" checksum="061850DAC2096827" modified="2022-01-19" version="1">MSQSPQDEPQPNQTPSLYLHAELLPNIRQLILYISVPPNTPRSDLQISLSDSRRAVTVTVPSTTNQDGPSSISETIKLPARVSESSRRILQQQPPSTQSESEYSFRMQVDDNDTSLHKDDSTLNDGFIPWTATDMSAHTRLRCVKCHSPILNEGKVWKDLPSGNWAEMMDFWHCHKPDPPEEEKNKGGEDPNAVVKGYGAGNQLVAVEGTVLVDVTSFLVKGVDCLGPASEPEPTILTCKSCTTQLGLPDPIANGYRLFKTSLSANTPSTSSSQHNHPEESWESHPPETILTAQLLELIERESYRRFVIHCGAKEGLLIWPFNPSLRYSTTSASHSTAAQLAMKVFYQHIDNVEEVLHPEVGKGSQSLAIEEVRLPGEEAYRELVGVLEERNGMLPASARVFREWRVGLLWRFERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ50</accession>
    <name>A0A8G1VJ50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Poly(A) polymerase</fullName>
            <ecNumber evidence="11">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_507519</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="11"/>
    <dbReference type="EMBL" id="KZ825085">
        <property type="protein sequence ID" value="RAH52388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510310.1">
        <property type="nucleotide sequence ID" value="XM_025664410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ50"/>
    <dbReference type="GeneID" id="37167812"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="17">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="16">
        <location>
            <begin position="211"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="15">
        <location>
            <begin position="358"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="15">
        <location>
            <begin position="498"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RAH52388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="579" mass="64800" checksum="79E83978F32E3D49" modified="2022-01-19" version="1">MAAPPVRQWGVTPPISTVLPTPDELAANDDLITELKVQNNFESPAETERRKQVLQLIQRVTVEFVKTVSRKKGLSQAAVEAAGGKIFTYGSYRLGVYGPGSDIDTLVVGPKHVIIDDFFSDFPPILEKMAAPGAIEKMTPVPDAYVPIIKLELSGISIDLIFARLIIPSIPMNLDLKNNDYLRGLDEREVRSLNGTRVTDEILELVPQQKTFRLALRAIKLWAQRRAIYSNIVGFPGGVAWAMLVARVCQLYPQATGSVIVGKFFRIMNKWAWPQPVLLKPIEDGPLQMKVWNPKIYHGDRFHLMPIITPAYPSMCATHNVSMSTKAVILRELQRGGDIVDKIFLKQLRWEDLFARHTFFTKDYKYYLSITASSRTKEAESVWSGLVESKIRHLVGALDRKATIAIAHPFPKGFERVHRVSSDEEIEAVKTGSTKYQDKGTKTETTDEMKDAAHQAAAQNGAENTDVAAAENKPVDDTHVMYTTTYYIGLELKPLEPGYQPGINDLAITHVRNFDLPEDVFQPGETRPTRPKKKIVKKAEISGQKRNIESLDVSASKKAKVAYEQRTGYHTNFDSSQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJ56</accession>
    <name>A0A8G1VJ56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_523250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511869.1">
        <property type="nucleotide sequence ID" value="XM_025665329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJ56"/>
    <dbReference type="GeneID" id="37168731"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="644"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH53947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="825" mass="92928" checksum="436A56E354BE4B30" modified="2022-01-19" version="1">MEDAPGSYPFGVANADDTPLQIDPENPAVRGINEWPWGSMSPGLPPAAFRPYSLPQFMDRPGPYPYQSSSSSSREVSGSAAKVAIPRTTSSSSQSQRRRSARACEPCRQRKIKCDGNKPVCRQCIDHNVSCFFVDVKRVRDQKQLGILGKKVEQYEHLLQDLEKEVDENVARRIRKVLRGTDITSPPDDDGDSDSGTSSIGSLEALDLVEEDLNRSEKTVATGFYGKNSEVAWMQRLEDESENRNRRKEDSVDMEDGVGGGPATSSQQKQETAMAALSYHLDDIGVPLLDSVDPYALPPKDIANRFFTAFMDSVHPSFNVVRKTAFVSQYRQFFSQPAQPPQRWLAILNMIFAIGCRFTKATSGRTDGRDYDDLVYLNRARKLTLSEKVIFEHADLQQIQVEFLVALYFVSMCQINRAFKFSSMAFRSAVSLGINLRFVDDRTQYPAKEARIRLWWSIFLLEHLLTAITGRVSCVGENLSATPLPLPYEEEAFGRPDVLPLLQDSSLRMTRLKLTLLQSEEESRADVSWLPSCEPSPSLYFHCIVDLATITQSIINKVYSIQGLRERSSQVEQRIRRFSSILDMWLSKVPEAYRFTSGSGDQLDLPKERSAPWMRERISLAMSYYSARITLCRPCLTHTGLGPGVASPDPAVPPSARAGSRRNSRSRVHFNTSMALTCVRSARSLLCCLPPKPDIAWLTTMTPWWCIMHYIMQATTAILLHLSSLPSRSDDDPMHQLAADVEATARETKKSLRWLHHMAYKYPAARRAFRQCKSIVRRIAPSLGIDISDVPCGKDLPTEDDAYHLRDIDETPNSHDTAMEFEQHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VJB3</accession>
    <name>A0A8G1VJB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_427857</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512034.1">
        <property type="nucleotide sequence ID" value="XM_025658176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VJB3"/>
    <dbReference type="GeneID" id="37161578"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF24">
        <property type="entry name" value="NICOTINIC ACID PLASMA MEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="48"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH54112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="485" mass="54135" checksum="615B00B9D174906B" modified="2022-01-19" version="1">MDRVVERKSLEKPFEQAPPEETAIGDIDDVVLDPAKEKKLLIKLDMAFVPIIMLTYLSCFLDRSNIGNVKVAGMPEDIHASDSEYSTAVSIFYATYVLLEAPWAVAMKKLTPRNILTGLCIIWSITTVFTGFIHNVASLYATRLILGGCEAGLFPCLNLYLTMVYRREEQAKRVSYLMSCAAISGAVGGLLAYALLHMDGIGGKAGWRWVYIIEGIFSLVCAVLIWFGLPNDPSNAYFLTDEEKYMMRVRNEQRRKYMGSEHFSWEEMRIALRDPKLMFSALTQFCQDILLYGFSTFLPTILGSLGYNSLMSNVLTVPVYIWAAIVFIAVAFCADRFGRFSIFILVTNIFGIVGYILLLTVSSDPVKYFATYLCGVAVYTGVGLNVAWLNVNVAPQYRRALAIGLQQTVGNCAGIVAGQVYRTSPYVLGNAFSLGALVVSQIIVALHAMYLRRENKMKEDILAGEKEDTRRVKTGDGEVEFRYHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VKL8</accession>
    <name>A0A8G1VKL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_451078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513757.1">
        <property type="nucleotide sequence ID" value="XM_025660512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VKL8"/>
    <dbReference type="GeneID" id="37163914"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH55835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="229" mass="25806" checksum="D5E6735E39CB58C1" modified="2022-01-19" version="1">MRPANFLRALQPLRSSMMRSTTITSSTTAPSLYQTTLRSLTTTVPRLNEQQQQQQPQQQEADLSSSTTTTTTTAVPPSLRSYPYKTKTGTVVSVGRMDRTVRVSHRHTIWDAHIQKPYPKITNYLVSDPRNSLREGDVIEFSSGYPKSRNVRHVVERIIAPFGSAIEDRPAVLTREERDAERAAKRAAKWERREARRAEAGVSEIEGKGGEHVGRIRRLVLERIGGVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMD6</accession>
    <name>A0A8G1VMD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_469020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515587.1">
        <property type="nucleotide sequence ID" value="XM_025662307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMD6"/>
    <dbReference type="GeneID" id="37165709"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000131">
        <property type="entry name" value="HAD superfamily hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="292" mass="32356" checksum="B0F8E07345568A62" modified="2022-01-19" version="1">MPSSAQNLPRVRACLFDMDGLLIDSEDKYTDITNAILQEYGKPLLPWSIKAQLQGRPQPDASRIFHQWAQLPISPEEYAAKQSALQEKFFPQSQPLPGVRDLLAKLVSTQTTDQPVHLALATSSHSRNFKLKASHLGELFSAFPKSQQVLGDDPRIGKGRGKPLPDIYLLALETINSSLREKGETEIKPEECLVFEDAVPGVEAGRRAGMRVVWVPHPGLLESYKGREEEVLAGLTGEHKEEEKTEPEREADELVAGRLKSAGKPGEIGDGWGELLPSLENFPYERYGIKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VME7</accession>
    <name>A0A8G1VME7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Lactoylglutathione lyase</fullName>
            <ecNumber evidence="3 9">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_449440</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-S-lactoylglutathione = methylglyoxal + glutathione</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3 9"/>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515379.1">
        <property type="nucleotide sequence ID" value="XM_025660167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VME7"/>
    <dbReference type="GeneID" id="37163569"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="40"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="196"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH57457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="349" mass="40000" checksum="A741669C599664FB" modified="2022-01-19" version="1">MFSLPAFRSSFLRVLVPRFSIVTGTNRSLATMATDTSKYKLNHTMLRVKDPKKSLEFYQYLGLNKVNQIDFPENKFSLYFLAYDGPQSLQGDRHFTDRNGVLELTHNHGTENDPNYSVVNGNTEPYRGFGHIAVSVDNIEAACKRLEDAGYPFQKKLTEGRMRHIAFVKDPDGYWVEIIRRHNEDVGTTTDPSTYRLNHTMLRVKCAETSVKYYQEVFGMTLLRTIENKDAGFNLYFLGYPGANPEKREGATNPVSEWEGLLELTWNYGTEKQEGPVYHNGNTEPQGFGHICVSVDDLNAACDRFESLNVNWKKRLTDGRMKYVAFILDPDNYWVEVVQNEALKRTGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMX8</accession>
    <name>A0A8G1VMX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Enhancer of mRNA-decapping protein 3</fullName>
            <ecNumber evidence="8">2.3.2.27</ecNumber>
            <ecNumber evidence="9">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Cyclophilin-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cyclophilin-like protein Cyp-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Peptidyl-prolyl cis-trans isomerase-like 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">RING-type E3 ubiquitin transferase isomerase-like 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">BO85DRAFT_424050</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the EDC3 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="8"/>
    <dbReference type="EC" id="5.2.1.8" evidence="9"/>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514075.1">
        <property type="nucleotide sequence ID" value="XM_025658032.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37161434"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01923">
        <property type="entry name" value="cyclophilin_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000007">
        <property type="entry name" value="YjeF N-terminal domain-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16 27" id="KW-0413">Isomerase</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0697">Rotamase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DFDF" evidence="25">
        <location>
            <begin position="268"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="24">
        <location>
            <begin position="445"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="26">
        <location>
            <begin position="759"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="23">
        <location>
            <begin position="1036"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="62"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="166"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="336"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="944"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1161"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1212"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1265"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="389"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="961"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1169"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1219"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="1266"/>
            <end position="1280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00015797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00020592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00033051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="RAH56153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1300" mass="141557" checksum="AD34DE7434EDD753" modified="2022-01-19" version="1">MAAEFIGYDVLVTLRAPPNATVQGEVANVIGQRLMLRNVKLSWIGHPLPTYSIEAPDIADLSLGSSTPRISQRPPPPPPQGSQNIAPAPPPPTASQSFVDPAILSFSKPPSAPSSQGADSGPVQLPAPSISRSTSQNFQFPQVAHRDQAAVLNEPFSNLELDVGKTTNESRSAVPSGPVPAGRENIVSSQPTPQSAAKASRRTGQPRTPKAVNEHDGATNTDPRSKGWRQTAFVEPSYPQMNKSLNKQRRKKRNNRSNYVEDPNGWATEDATDIQEMGEFDFQSNLSKFDKRKVFEEIRNDDTTADEDRLVSFNRKVPKPGTNGGKNLHWTENVLDSPEETESEDTDQVPSDAKLSSGTYSGRERSRTSRAPSSRKGSAILGQPLVPPQINSLGRSQLSTSRTTSPRPNKTSVSASPISAPGVPGGSLRLTTTNRSCPTVSPLQTLEVEQIAVAELGLTEDMITENTGRGIAEAAVGLLTSDAAAPTMLVLTGNHRTGARAVSAARHLRNRGHRVTVCMLGIEHDNELLESCRKQLDVFKKIGGRVHRWEDLSTRLSTSEFAPDLVVDALFGIHIAFDDLRTDDQATAFEMISWANRSNLEILSVDVPSGLSAMSGEVTTVEGGRLCVNSKSVVCLGAPKTGVVTALLSGEGLSWNLSVADIGIPQIVWRKYGSRRRHGIDFGNRWVVPLRYQPPPWGVTGRQEYPTINAWLSGGKGMIYCDDGAFITHSEWASEDAFSASAGAGVGRAKRGGVDTAFKRLPFNFCSLSLQPFSHPVCTPSGTIFDLTNILPWIKKHGTNPVNGAPLKSSDLIKLHLAKNESNEYVDPVTYKVFTDNTHIVALRNTGNVFAWDTVERLNIKGKLWRDLVTDEEFTRKDIITLQDPQNVESRNLSSFNYLKEGESGLTDEQIREREDPSNNVNVNALGSSAKILKAKEAVAKARAERSQRVGSAAASKDLTKSGNAGNTAQSQKTASFQSGKAVPYNAAKHTTGLAAASLTSTGMTPHTSAELALLSDEEYMLKRGRVKQKGYARISTNVGDVNLELHTEYAPKAVWNFIKLAKKGYYRDVAFHRNIKGFMIQGGDPSGTGRGGESIWGKYFNDEFEGPLKHDSRGTLSMANKGKNTNSSQFFIAYRALPHLNNKHTIFGHVIDDPTPSSTTLNNLEVHPTNPTTNRPTPDIRITDVTVFVDPFEEFLKQKQTEEAKAKGLLVNPEEEEQNARRAEDDRMTWTGKRVRGAGSGEKDEGSGGVGKYLKAALAERAGQEEDEIVEFIDDEPEPEPMRKKFKGGGGFGDFSSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VMY9</accession>
    <name>A0A8G1VMY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_459226</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825061">
        <property type="protein sequence ID" value="RAH58027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515949.1">
        <property type="nucleotide sequence ID" value="XM_025661638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VMY9"/>
    <dbReference type="GeneID" id="37165040"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030586">
        <property type="term" value="F:[methionine synthase] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000027">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000007">
        <property type="entry name" value="Methionine synthase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF84">
        <property type="entry name" value="METHIONINE SYNTHASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="225"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH58027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="646" mass="70821" checksum="15112D58F6BD56C9" modified="2022-01-19" version="1">MVHAVLPPPPPSRPVTSRTSLVPNVEHAIVPRSSTSHPDNPVPEEPRGVRSLSITDVNFSVSTPSSPETDTTGSGTSSGVQTPATELQSEAEDSTRDGSEKQRRASTVLISQNSDDMRRILENVGSSGTQKLQPLCCGGGCCRSKPLVNFTPPLAGVKAITPPDNKAYQCLKLNVDYLTLDSELSNVAPLPEKTVSFSSVPGYAVDVQLGPADHPPSFVQPHPPYNVYRAPLYHARELTGSGAEKRTYHFDIDVTDYPAESGNVDFIVGGAIGVCPKNKEEEVDDIFDQLGVPKFLRDKKIVVRTEKGRWPTIWGDDQPRELITTRRELLSWCSDIQSYAPNKALFRLLGEYASDPSEKKILLFLSSAQGQGAFCDLRTSSHVTVSQLLHAFPSSHPPLDHLLSVLNTLMPRFYSLSQDPLLSCKQKGSVTRRVIEVAVTVAESEDWKGGLRTGVGSGYLERVARRLIDAEKKGIDPQTLDLHVPMFRGLMANPLAKRFASDGPMLLIGAGVGIAPFRGFVQRRLQSANCANKVWVLQGVRDSLLDELYRGEWGVEEEKVRTVVQSRRGESKYVQEEVRNQADLVWYVINALDGRVFVCGSGKGMGEGVEAALVDVAMAKGNLNMEEATLFWENKKEAGQYIAETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VN32</accession>
    <name>A0A8G1VN32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adenylate-forming enzyme AfeA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_439991</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514225.1">
        <property type="nucleotide sequence ID" value="XM_025658744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VN32"/>
    <dbReference type="GeneID" id="37162146"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF317">
        <property type="entry name" value="ADENYLATE-FORMING ENZYME AFEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="72"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="488"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH56303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="609" mass="66792" checksum="B74BCC3737E96D17" modified="2022-01-19" version="1">MGSLWESPTLGDPFNLTHPDNHLDHANNHGITHGDGFYTDLLTFAFRGPVHYDRQQPIFIDAEDATRFFNALQFETLVRALIAGLKAHNVQPGDCVLVHLGNSIIYPALFFSIIGAGGVFMGSNARSQPQELEHILQLAEPKLIITSSDALPTVLSVSADRGMHPSQVCLVDEAAGDYISQYFLAGPLAYATAGASYLLPSSGGGSVVNFAHLLAYGESDWVAFDDEMIAKSTPAAMFSTSGTGGLPKAAYLTHHAMISHHLTIQYDVPYEVTRLMSLPMFHMFGALWTHLFPIRYGEPLFVLSRFEMNLFIRTVRDFGITETYMVPAMIHKFNRSASSATSSLSSLRYVGVAGAPIDAAAMQRFRELLHSDARASQLWGMTEVGVVFQNRYGPQQAPAGSIGRLLEGYEVRLVGQDHQLVLEDNQPGELWVRGPGVLSGYKGRSDAKDARGWFRTGDVAYVSAGQFYIYGRTKELIKVRGWQVAPAEVEAALLKHPEIEDAAVIGVTSRDGSTELPRAFVVRAKSLTGSRLTADDVYNFARHQLASYKALDGGVIFVEEIPRTASGKIQRFKLSQMNTYREIVSNLLARFKGASMQTVGIMHPGRITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNG7</accession>
    <name>A0A8G1VNG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_487302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516504.1">
        <property type="nucleotide sequence ID" value="XM_025663446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNG7"/>
    <dbReference type="GeneID" id="37166848"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH58582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="114" mass="12545" checksum="CB7A845BFD988E4C" modified="2022-01-19" version="1">MNLFSTLSSPLLVRTARLSIASPGARYITSTAYRLAETKAQDSSHQKQSNDASDNQSASKLKQDKTKNVAQADQELRERLEQMSGGGGASGIEYEDGKPSAMKRSVRNNMFRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNI1</accession>
    <name>A0A8G1VNI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protection of telomeres protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_395781</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the telombin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516549.1">
        <property type="nucleotide sequence ID" value="XM_025656973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNI1"/>
    <dbReference type="GeneID" id="37160375"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04497">
        <property type="entry name" value="hPOT1_OB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000303">
        <property type="entry name" value="Protection of telomeres protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032042">
        <property type="entry name" value="POT1PC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16686">
        <property type="entry name" value="POT1PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="10">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="340"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH58627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="606" mass="69124" checksum="41D011B1A3C19BB2" modified="2022-01-19" version="1">MSRFVDVSTALSAQGRVSVIGVVVDVFGGIWKSRGSSSCITFTIKDSGLDNGHTWDGLKIKYFKDNESHLPPVQLRDVILIRDLWVRNFKGDPLGVAAQDREVPWAIFRLDPDPTSSPAPLCGPTHFEPSPSEKIHALNLMNSLPAVDGFRKAPAQDTPRGPYIVQAAIPNSKPYPHKKLSLVKDIVERNYVDLVGEIVKIYTNDSEKVVLYFTDYTANNGLEDRQIDDAGDNGFGTEGDVYGYQKRPKKKWTGPVGRMTLTITLWEPHASYARQHLKNNDLIQLYNVHVKRSRINGILEASVHTNRTNPNSVNVHTLDRRKDTFVVQFLQRRTEYWKVNPRKREPENEAQQVPKRSTKKQRKRAEKVEEGQVSITAASSKRYALNENIIAGNPSVPTMSLEAILSNKLHDNISYDNIQYRFPFQNFCYRTTVRVVDFFPPRLEDFSVPEDSSGEGTSQRDPDRFIRWEWRFCLLVESVPPPTAGQAKEQMRLFVAGPDAEYLLGLTAVDLRRNQHDLKELREKLFILWGDLEERKRAALHDGKQDIGPVSCRPFNCCIQEYGVLCRHRPDTENTTINNEDDENGCSHDDCFGWERRFAMFMTTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNI2</accession>
    <name>A0A8G1VNI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ergosterol biosynthesis protein Erg28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_447697</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517748.1">
        <property type="nucleotide sequence ID" value="XM_025659773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNI2"/>
    <dbReference type="GeneID" id="37163175"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034299099" evidence="13">
        <location>
            <begin position="28"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH59826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="141" mass="15486" checksum="510321C463AB2BDF" modified="2022-01-19" version="1">MAALLSYLPPFEGLLPKWLFLVSVVSAANSIQAYRSESYAADLYNGKTAEGRPHTNPLSSRTFGTWTFLSSVVRIYAAYNLNNPAVYDLALWTFGIALAHFVGEWLGFGSAQLKGRFVSPLIVASSTLAWMLTQREAYLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNP9</accession>
    <name>A0A8G1VNP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium transporter 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO85DRAFT_447867</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH60006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517928.1">
        <property type="nucleotide sequence ID" value="XM_025659800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNP9"/>
    <dbReference type="GeneID" id="37163202"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053952">
        <property type="entry name" value="K_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053951">
        <property type="entry name" value="K_trans_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00794">
        <property type="entry name" value="kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF83">
        <property type="entry name" value="K+ POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22776">
        <property type="entry name" value="K_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="462"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="11">
        <location>
            <begin position="77"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter C-terminal" evidence="12">
        <location>
            <begin position="585"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="683"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAH60006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="787" mass="87560" checksum="16C32D3DE5FDF1D0" modified="2022-01-19" version="1">MDPDPEGLKELPSLATVKEKSQQTQDSIYNIRPWNNNHLDRAISTVSTIGEDDDPGLRRPTDFKQRQDFSGKMLLWLAYQSIGVIYGDIGTSPLYVFSSTFTEAPSRQDLIGVLSIIIWSITIMVTIKYIFIILHADNDGEGGTFSTYSLLSRYMNITHRDPREASLVQMKRHLSIDLESSSRFARHSLETSKFAKRLLKVVGVLAVTMVLADGLLTPAQSVLGAVQGIEVVSPNISKGTVIGVTDAILVILFLLQPLGITRVTFAFAPIVIIWLGFNAAFGIYNLAKYDAGVFVAFNPGYAFTFLIRHGESGWRMLSGTLLAFTGVEALFADLGAFSRRAIQISWLCYTFPCLLLAYIGQAAYISVHPEAYSNPFYKAAPPGTIYPALVIAILAAIVASQAIITATFQLLAQVMKLSYLPQFKVVHTSDIFHGQLYIPLANWLLMIGTILVASIYNNTTSLGNAYGVCVIFVTFFDTCMVAMVAMFVWRKSPYLVFLPWLTIACFDGAYLSSALTKVPTGAWFTLAVATILALLFLLWRFGKEQQWFAEAEDRFPTSHFVTKNQDGSIRLTDRFDGAPLSTTQGVGIFFDKAGETTPIVFSQFILKLTTMFETIIFFHLRPLETPSVPIDDRYTVSKLAIPNCYRLVVRYGYNDEIISPDLASTITDQVRKYLIEHRHTTAPTEASTSISQLSRDIGQDSTSAEESRTITSRGKPVDPVALLEKACAHNVLYITGKEQMRVKRDTNIFRRFVLEIFLWIRDNTRAKIASLGLGAEKVIEVGFLKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VNS3</accession>
    <name>A0A8G1VNS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_365939</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518136.1">
        <property type="nucleotide sequence ID" value="XM_025655760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VNS3"/>
    <dbReference type="GeneID" id="37159162"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="40"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH60214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="469" mass="53688" checksum="E53890022329D8C5" modified="2022-01-19" version="1">MPSAGPPLPPGILVDEEISPVYNPKYFYPAKPGEVLGDRYQTLVKVGWGVSSTVWLAQIEEPGSVVALKIANNNASFAGHECEVEEHISTADPSHRGRSIIRTLLDSFQIEGPEGSHSCLVYPPMREPLSMYQRRFDEKKMPLPLVKTYIRALLTGLDYLHKDCRTVHTDIKLENNMVSFEDPTVLAEFIESQLEKPMAFKVDSTGRPVYQSRSDFGPLKSLRSIPQLVDFGLATRLEEDDDWGVWPIQPDHYRAPEVILGIGWQMPADIWNLGVLLWDLIEGKELFQHIHDEQGRYDAKLHMAEMVALLGPPPPEIMQRYQDMREYPWPEPVRREDDRLCETAEEYFDGPFFDNNGRFIYEDLIPNRTLDDAVSFLDEEERDNFVDLVKKILVWHPNKRRTAGELAAHPFLQPKQTITLFSASACWWTVRRWHQTAGSDVSAIVISNGMYSWVRLCMQTIQLDFGLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP27</accession>
    <name>A0A8G1VP27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF967 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_397336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515245.1">
        <property type="nucleotide sequence ID" value="XM_025657016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP27"/>
    <dbReference type="GeneID" id="37160418"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.150:FF:000005">
        <property type="entry name" value="UPF0303 protein Ping_1243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="YBR137W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255:SF1">
        <property type="entry name" value="UPF0303 PROTEIN YBR137W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH57323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="189" mass="20279" checksum="A97B57455D7E3FEE" modified="2022-01-19" version="1">MEDTPLPPASTDPRDLAALESNPSVLFPSFTSSTAWTLGLALRERILSLPPTQRKPALISITLTGGSEPHVIFQCATEPGTVADNEVWVRRKRNTVLRWGVSSWLMRQKMLSSTGAEASEVEAAFVRKFALTSSGGGGAADEFAIHGGAFPIRVRGVDGIVGVVVVSGLKQEDDHQVVVETIREVIAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VP62</accession>
    <name>A0A8G1VP62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_485983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517432.1">
        <property type="nucleotide sequence ID" value="XM_025663358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VP62"/>
    <dbReference type="GeneID" id="37166760"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="80" mass="8822" checksum="B5868402B318C92B" modified="2022-01-19" version="1">MSEHETQVPTPAFSQPPHEQKESLIDMLHLNNVTSHIVNAVGHITDAESDTDAIDHDDHVLVFDNPFKGAMDGDDDETSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPD9</accession>
    <name>A0A8G1VPD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular serine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_447245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518603.1">
        <property type="nucleotide sequence ID" value="XM_025659680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPD9"/>
    <dbReference type="GeneID" id="37163082"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056825">
        <property type="entry name" value="Agd3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056826">
        <property type="entry name" value="Agd3_CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056827">
        <property type="entry name" value="CBM87_Agd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050788">
        <property type="entry name" value="Yeast_SRP1/TIP1_CWP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002:SF34">
        <property type="entry name" value="CELL WALL PROTEIN CWP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002">
        <property type="entry name" value="SERIPAUPERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25117">
        <property type="entry name" value="Agd3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25115">
        <property type="entry name" value="Agd3_CE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25116">
        <property type="entry name" value="CBM87_Agd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034469536" evidence="1">
        <location>
            <begin position="21"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 CBM87" evidence="3">
        <location>
            <begin position="143"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 deacetylase" evidence="2">
        <location>
            <begin position="369"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 C-terminal" evidence="4">
        <location>
            <begin position="736"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH60681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="804" mass="86118" checksum="1E6E7457F60AA6D2" modified="2022-01-19" version="1">MNTLKSSIISLNCFLGFITCNTPPGIWPLKPTVLTSASSASSTPVAEVTGPTAPGTTSAVHSLTSTTTSSFVSFLSSTSSAPSSFVTSVASPTTFVDTSVSGSASALSSSTASTMSVSLSLSSSIVASSAVPAATPVSSGSIAANILVIARDTASAGVASSGLNAYGIPFTTLVVPQSGTSLPALNGTEGGNFAGIVVASEVSYNYGNATGYQSALTTDQWNQLYAYQLAYGVRMVQYDVYPGPSYGASAAGDGCCATGVEQLMSFTDISDFPTSGLKTGAGVSTSGLWHYPATVSNTTSTKEIARFAANSDSGSETTAAVINNFDGREQMAFFISFDTTWSATSTYLQHAWITWLTRGLYAGYRRVNLNTQIDDMFLETDIYKPNGTTFRITPADLDGIANWLPEINGKMNAGSNYYVEVGHNGNGNIEAAAGVSDEGYTTCNQGGIEYDSPADTPLEWKKPVGTGTNLWPSSPTTYDWSVACTQLDPLLLWWTNTTNQDKFGHISHTFTHEEQNNATYSDVYKEISFNQAWLKQVGISSAKHFTSNGIIPPAITGLHNGDALRAWWENGITNCVGDNTRSALLNQQNDMWPYWTNEASDGFDGMQVNPRFATRIYYNCDTPDCTLQEWIDTSAGSGDFDNLLATEKGEVMRHLFGLHHDPYMFHQANLRNADVDPITVNGVSAKYSIFQAWVETQVQEFVRLVDWPLVTINHEAMSASFLARYTRDACNYSLRYTISDHKITGVTLSATDNTCNATIPVTFPVVPTNTQSFTTEQVGSDPLTVWVQLSGSPVSFTLSTPIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPN1</accession>
    <name>A0A8G1VPN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentatricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_393796</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517794.1">
        <property type="nucleotide sequence ID" value="XM_025656897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPN1"/>
    <dbReference type="GeneID" id="37160299"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050667">
        <property type="entry name" value="PPR-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939">
        <property type="entry name" value="MEMBRANE-ASSOCIATED SALT-INDUCIBLE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939:SF13">
        <property type="entry name" value="OS03G0201400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="4">
        <location>
            <begin position="348"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="492"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="600"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="642"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH59872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="692" mass="78254" checksum="290ED8CE41A0D3BE" modified="2022-01-19" version="1">MPRTTLVLDGLWYCLCPSFNAATFNRATPSFTAGRRIPKHDRITALRSSISDPPRRCLTNLTPRPTDAAIEIVEDNRHTFTNSSSSSDQQPSDPDDAGAQDNVRPGDLLSPMERLTKPPPGVPKYFKHLPSQRLENRLQERVARYPRVLSATQILRVLIRDRHVRPEMRHYRGLILANSDPERGSPQAVRALLKEMEENGIPADSGTLHAALQVLAVHPDYLLRQEIVRTLRDRWLPLSPAGWHFVVAGLIREHQFELALDHVEQMERKGMVVENWLHSLLIYYLCDFGEFDEVVRLMRSRTSQGLDMSSELWLYVLEVASAALHYDTTRYIWRQMVELRYLHPGYPLCSNVLSVAARAGDTELAASVIRFLVEVNVQPQLDDYEKMVEAHAVSGSLYSAFEVLCKMHMADIAVEHRSTRAILTHLLQSRTTPRGAWTMLKQLKATKLTVPLGCAKVVLEMCEHEALDNPSVVYEGIAFYKELYALCPDKADVTVYNILLGMCRRARNTEAGMFIAKEMASLGVIPDQGTFEHLIVMCLEAGNFESGYMYLQDLLGRGIRPGEETRAAIRELCSPSEDPFASRLRHHPQIQDGSVGCLVDEISNTHEPPDSTEQEEEGNGKEESFHRSGQTPTQAEMERQALHKLRRAAAKERRKRKRRLAAIAQGQEEEGWLDYEPGGLIPEDQLDAKSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VPS4</accession>
    <name>A0A8G1VPS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO85DRAFT_391558</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518062.1">
        <property type="nucleotide sequence ID" value="XM_025656815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VPS4"/>
    <dbReference type="GeneID" id="37160217"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="97"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAH60140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="477" mass="55277" checksum="4B03B6338655A2F3" modified="2022-01-19" version="1">MHSHIIPNMRKPCLLLRQPLRLTVPFPCYDLPLRASQPFLPRRIYRVFSLTRYRGTGPAKKTTRVIYEPIEDVERMEYYEAGGYHPVTIGDCFHHRYRVVHKLGHGTYSTIWLARDKVSKRYVALKICTADSNTPENSVLSRLSQPQQSSRLDRDLFPTISDIFNIQGPNGNHTCYVTRPARMSLSDAKNGSWISLFQLEVSRAIVAQLIIAVQYTHSQGIVHRDLHRGNILLRLCRDFDKLSTDMLYEKYGEPVLEPVNRLDGQKIPPEVPQYGVVPIWLGAVSEDVTLPEAKICLSDFGEAFCPTHEQKIESHTPLLVRPPEARFEPTQPLTFSSDIWTLACTIWDIMGQRTLFEGLLTNDDDMTSQQVDLLGPLPPEWLTKWKEIRKKDSKSTHQPPTSPTQSWEDRFEQHMQRSRIREGMPPFELKERDAFILMLRSMLRFRPEDRPSAQQVLESEWMVKWALPEYEKIRNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQ34</accession>
    <name>A0A8G1VQ34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD+ kinase Utr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_110594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825055">
        <property type="protein sequence ID" value="RAH61609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025519531.1">
        <property type="nucleotide sequence ID" value="XM_025653849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQ34"/>
    <dbReference type="GeneID" id="37157251"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000005">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000025">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="604"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="646"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="660" mass="71595" checksum="EF7C1D22A1F9A2FE" modified="2022-01-19" version="1">MASSPLDHGSMNHPSSSSATGPLPSSSTSLPSSPPPPSSAAPPLSVPPVRPPPPHRSATVGASLLRDYASHIDPSHTTNDIHTADSAPGTPNLGPSTGTLQKPDHPREGAAVPAFTTSFLPRRQTASLAGHHRNALSNDSIPRQTLLKALASRPSMCNHQSPNMPLAASLGLLNTNPTSSEETERTSSNSSSQMLSAALSNIQLGTYLDRSPATARLVMQSPCFFHQRFDDAVNIQKVLEEIADDEWLSHSRLVQTATGVREVSKQLQRRPIKRAVKNVMIVTKARDNSLVHLTRELAEWLLSTPRYGNDLGVNVYVDAKLRNSRRFNAQGLLDKEPRFEEMLHYWTPDLCWTAPEKFDLVLTLGGDGTVLFTSWLFQRIVPPVLCFSLGSLGFLTNFEFENYKSHLNAVMGDVGMRVNLRMRFTCTVFRKDRSKGAEAGAVEEGEQFEVLNELVIDRGPSPYVSNLELYADNDLLTVVQADGCIFSTPTGSTAYSLSAGGSLIHPSIPGILLTPICPHTLSFRPMVLSDTLLLRIAVPAGSRSTAYCSFDGKGRVELRQGDYVTVEASQYPFPTVVAGGGEWFQSVQRALRWNTRGAVQKSWHSASDAGLEATEDDEDTEWDIDTDAGLTGTDSGLGVSEDGDAGSNSPLKRQMSMFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQG1</accession>
    <name>A0A8G1VQG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_458879</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516655.1">
        <property type="nucleotide sequence ID" value="XM_025661611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQG1"/>
    <dbReference type="GeneID" id="37165013"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000024">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF67">
        <property type="entry name" value="MFS MULTIDRUG EFFLUX TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="583"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="124"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH58733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="620" mass="66775" checksum="83C8F07AE64150E2" modified="2022-01-19" version="1">MTSPHATDGKPPSSLQATESTPLLHESSRQSLYISQEDTTVDKDVDPSLSSTLFAPEEDPALLSLSRVTSIPQGLDVEPNLERLPSAPVSQKQVPGDAEDGVAGEPTGYASRFINVSPMRFWLIFSGILMGYVIGFFDSTLMASSHPVITSYFHASNSASWLSTAFLLTSTAFLPLFGRISDTFGRKPVYLFAIAIFFVTTAWCAAAQSMFSFIAARAFCGLGAGGVFSMGMILSSDLVRLEYRGVYQSYINLCLGIGGCLGLAFGGFLCDQVGWRGAFLVQLPFIFVYFIVAAWTTPADLGLKRAKTERKSLMQLLKSIDLVGSFILVVGVTSLIMGLNLGGNVFSWTHPIVITSLISSFILAVVFVRYERTVERGVMPISLLVQEPRASLIFGNFFGAISVNTMVFNAPLYFQAVKLATPTDSGLRLIGSTLAVTISSVSTGFIITWTKRLKPTIIFGDIFLLLGGCAAASMGVGTPDWLAMVCVSLSSLGQGCSFPSLMVSVLATTDQEDQAVATTTLGLWRNLGSVMGVATSSWIFQNTLVYQLEETVTGPNKEDVILLVRKSVQAIAKLDSMHQQQVIGAYAAALRATFFSAAIWGALMLILHLRVRVPRLGTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VQV9</accession>
    <name>A0A8G1VQV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat and BTB/POZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_437258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517105.1">
        <property type="nucleotide sequence ID" value="XM_025658614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VQV9"/>
    <dbReference type="GeneID" id="37162016"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18497">
        <property type="entry name" value="BACK_ABTB1_BPOZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000248">
        <property type="entry name" value="Ankyrin repeat and BTB/POZ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000183">
        <property type="entry name" value="Ankyrin repeat and BTB/POZ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000158">
        <property type="entry name" value="Ankyrin repeat and BTB/POZ domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044515">
        <property type="entry name" value="ABTB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="154"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="352"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH59183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="639" mass="72293" checksum="F1C4919A3FF563CC" modified="2022-01-19" version="1">MMTEEPKVLRKDQLEVSLHNEKKLIKEGAIKDDNPLDLSEPFRELCNACRKGDLKVCQEKITEGVNINARDPYDYTPLILASLCGHYEVVQLLLESGALCERDTFQGERCLYNALNDRIRNLLLEYDYSKSTNPLQPLAAHITSLLTRETPITSDIVVTAADESLHLHKFILAARSPYFHRKLESAPDTSTWRLPNTIPPEAFGTAIKYLYFGEAPRDLRSGPGTGFTESEVFAGIDKIAKHLEINTLVDSILDSGDRRLARQRRTMEVAKGRDQLEEWFRANVLKHKVTVETAKADDIKWDRDNAIYADVLLRADELPEDDEEIVEASELTEAERGRSNGSGRREPMSTLFPCHRAMLLRSEFFQTMFASPFREAHMKDHLNVISVDCSPDVLEIVLTFLYTERADFPLDIAVDVLFASDMLFIEKLKTKAAIVISTLGSGNMSQAEAARTRGTKEEDDLDIYAIIKAAWLTRVQRLEEFAARYLAYRLEAHIDSPEFAELIQESASRIQSRQETDSIELLDDIRFYLGERFRLRFDDAGIDEMMEPTQPVADGVEVNGDVEKVTEGVEAIQLSKEGSGDRTSVAVPPEQAALKVQEQPLIRTLDGEVAVDEFDQDAINYQILMEKLDRILENLNLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VR26</accession>
    <name>A0A8G1VR26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell surface spherulin 4-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_458487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517285.1">
        <property type="nucleotide sequence ID" value="XM_025661588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VR26"/>
    <dbReference type="GeneID" id="37164990"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF9">
        <property type="entry name" value="4-LIKE CELL SURFACE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54178" checksum="392FAB0FA9D23A71" modified="2022-01-19" version="1">MPRPNLTRPRRPWCIAISIAIAVVIIIVIVVPCAVLLTRKHGGEKTNVLFPLYIYPTNDSTWDPLYESVTTHPDLNFTVIINPSSGPGSSAYPSEDYTSSVERLSTYSNVRKVGYVRTAYATRNITAVLDDVATYAGWANRSLTLAMDGIFFDEAPYDYSAAKAEYMQTISEAVKSSSGLRRDRMVIHNPGTIPDSRYENNATDVTVVFESSYQDFHTEKHSLNAMASNRTAYAYMLHSVPDNLSNGTLRSFVNQMSRKAGIAAYPELEFLVIVNPNSGPGALPCPDANYAREVARLNACPNVYPVGYIRIDYCRKPLAAACEEIDRYASWAAEYATTGLGVGGIMVDETPNHFNAAQAEYLRALHRHIKNCSGLLRDRLVVHNPGTPPDPEMADAGSDLLLVCEEPFARWQTNEVQHRLGELPYPRDRCGYMVTEVPNHHLPALVRDLRRRAAYIFVTEIVGDFYERFGPSSWGMLMESLSEQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VRG1</accession>
    <name>A0A8G1VRG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PEBP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_510716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517660.1">
        <property type="nucleotide sequence ID" value="XM_025664564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VRG1"/>
    <dbReference type="GeneID" id="37167966"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF78">
        <property type="entry name" value="PROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034486124" evidence="1">
        <location>
            <begin position="17"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="196" mass="21479" checksum="2DC5D407D9CE46A5" modified="2022-01-19" version="1">MRYLSLLSALAATALAQTPPGSSPSTNKNFGVAFPNATVTPGTWMSPDDITSQPAIYVTENLNKDATYMVVMLDLNIPDSDVTTAAYYDTLIPGLAVNTTTRLHWWGGNYTIQNGRFVNSSDAISEYTAPRPRDSTNHTYTLYLFDQPEGYVPFEEAANGTYYSQTAFARFNFTLEPILKAVGGPVAANYFLSDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VSX4</accession>
    <name>A0A8G1VSX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyridine nucleotide-disulfide oxidoreductase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_360426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521289.1">
        <property type="nucleotide sequence ID" value="XM_025655552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VSX4"/>
    <dbReference type="GeneID" id="37158954"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014839">
        <property type="entry name" value="Crt10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08728">
        <property type="entry name" value="CRT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH63367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="853" mass="94608" checksum="2ADE0B0265AA8D04" modified="2022-01-19" version="1">MAFGSDAGKLPKARPREGLQLRPLNVEKGSKRYCSADDTFPPQTATWRNNLMALSQRRNLLFVACSHQIYVWEPSGSFQTLGNKPEMIITPVMKVPHASGYIAPASPHAINNILVDDLGRDEVLLLVTDSGNVCGYRVEAIFSALKRATENKEERPLDGSQVDPFFVEFVQASAWGLAIHKFARLIAVSANTGLITVFAFALVNPTSESSSSSYQPDEDDDMIDYGQTWLEVRTKDQFSQLRHLMPARHRTRNVKLTYTGHYANIPCVDFLNCDLDPNGNWMVSTDIDNRLLVWRVWDSLGPFNVNHFNDVSFKFFPETLRSDERGWSVIALDPRTFHRVKSTEEACGGPPIRRAKNGRTVYDLTRANSRIPNASQIYNFFPPAVKIESEEPILPDIFGADCCISRRNGASQAAFADGTSSALRRYPSDGASTEFLDTNGLSTATGNMRPFDFADTFSHRAVNGSVYGDNLSRDGSDVDVGAHNAAGNGHFQSLNRAVQGVDALHIGPGPLTTPEFLQFALLEALGGEAPGTEFFEDEIDYYLAGGTYSSDHELDNADSSSSHNSDTSAAGPIPCPLLDGEHHHVDNMFDTNSAGSRFPILHFSQTDIRLIPHPFANYATAVCGDPLRQPLTHPVVSIRACDRFNMVKYVPEHGIVIAASQKGRAAVIALTESETTGLSFRIDWIVPLESQEKYGDRPLIPILGMSVSPIQGFEFPPDVPYIPRDVKPDDLAFQFKYLSHDEHNSSLSSSVMLQQNSFEEINNSEVDPSEPAAADDDNPQPPPLSLPECHARASSAYQPEESWRGWNPSRHYRLMLMYADHTIMSYEFWYKWNTTDSGPNGQDLDEEDDILLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1VVB8</accession>
    <name>A0A8G1VVB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutathione-dependent formaldehyde-activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_455660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825054">
        <property type="protein sequence ID" value="RAH63698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025521620.1">
        <property type="nucleotide sequence ID" value="XM_025661402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1VVB8"/>
    <dbReference type="GeneID" id="37164804"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="143"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH63698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="276" mass="29893" checksum="1F89C3E8B8E1C876" modified="2022-01-19" version="1">MEKATVHRIEGREVEKLEKGSPTEGTKQRSSRDAKARPSSGHDKLWFSQTVAANANSSPSSHVVNENGCLPPHRPSGSLGDNLLNLADGQDVSYKYVASSSTFLEGPHLVSTLVAFKSLLLSNQHSPPTPSHILHPIIARMPLSGHCLCKAVTYTVDVDAPLIVGYDHCDDCQRQSGSTYSLVAVVPKDKLTVNGPIKKWSGTGSSGHAVHRLFCSDCGSPIAHDPDAAPEIIALKAGTFDTEIKKNLKPDTEIWTVSKLPFCQEHLEKPFKNMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QR35</accession>
    <name>A0A8G1QR35_9EURO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BO85DRAFT_508115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825088">
        <property type="protein sequence ID" value="RAH52098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="37167844"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="410" mass="46803" checksum="3075606C7DA56428" modified="2022-01-19" version="1">MSYDNAATRAGFTSSFGRFRTTRGGNERVDSFSLRKLFLPKLSREGQKILRDRTDFVRSQLQHYGVPFEEDQLSGNGTQLMKKVLQEGKCDNVPVHILALEEQLHQEWIAASDIEVLSPNPEWVIKKFFIRAGEPDPYQTRTSTVVGISFPRYSEYRPGRLREAADQTIFLGWDKSTVREAAKEHANNEMTEIQAREQKREKERAKMHADYLAALERMKGAAGRNKSPVGSYIVDCEDIEGGWPSLAWDMVLEILDTQQKGKFHATFNFGVVIGVMVISEEHITETDEEEIGDDHEKIGKGTKRKKIARKQSRPSKKAKGERTSEPYMYRLKLRCCETGEGQIFFEPEYGTIKFSDENFAAFTAEAVFPCVGSGITFTARKVSDNPCPSGEEWEDYSEEAYEYARVSRWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QR77</accession>
    <name>A0A8G1QR77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_208547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="37157999"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
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            <end position="173"/>
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    </feature>
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        <location>
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            <end position="306"/>
        </location>
    </feature>
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            <end position="436"/>
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        </location>
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        <location>
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            <end position="29"/>
        </location>
    </feature>
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        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
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        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="400"/>
        </location>
    </feature>
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            <end position="481"/>
        </location>
    </feature>
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        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RAH52158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="564" mass="61508" checksum="11C79BE6AEB8BB60" modified="2022-01-19" version="1">MADGYNRPPGDSNAFHSCRNRSQTASILPTATPPRKRASSFYTVRGPEIVDESTPDPFYLEHTPGGASPWGNRRPGSRDVRGSEEGNPYSMISSVYSKDIPFAVTARGESARLRSNNNRSTLSVVELEHQLGLQQVASSRPWGTASGHHDHSSFSSVQTEATPDLTPSSSFSSNYSAPIYPDNSLPAVESLPVHAPPIPPSPRHNVYPYSSTPLNQSQVTLCTQPSTPVRQGRPHTATPNASSDTLVMHQGDSHDPPSHRGKPLPSLPNGARNGIAHSGRKGPPPPIRPPIAPSMISPPSRINPVTMEPHATHFEKAMFIPSNDCPSPVPSPSPGSPLLERYPTASSARDRPSTSASRPAYCEQSVWESDSDTESVDPKSLSKKPMDKLKKVRSRVHLRVAKSAPKLQPPQTPNSQHSNHLEKFSSMPDQPPEDLCPSPARKTVKARSREALRPAAETLRLVAPSTTSLVPPQSRRGSGQARTIDIDRTTAAAMQAKSRRRPRSDSKKSLSPEREKVCTLCREERSDKAILSLARPPLYKRVWESLRVLGCHGDITPPRSRRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QRF8</accession>
    <name>A0A8G1QRF8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO85DRAFT_454154</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="RAH52254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025661213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QRF8"/>
    <dbReference type="GeneID" id="37164615"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="16"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="155"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAH52254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="440" mass="48151" checksum="1C87E1E61979BFCB" modified="2022-01-19" version="1">MASKDDLKAHAASNEDFYALLDISPAAAESEIRRAYRRTALKYHPDKIANPTPADIDKFHTLQIAYDVLSDPSVRQLYDNAREARQRKQRERDMMDAAKRKMREDLEARERAGAAAMGGAGAQRGVKRPWMGGGADDDAEAKLQREIERIAEDGRRRRREAEEKLKQEMEEEEKLMRQEEEEAQRAADRSSQKVDRSKEGGTNVPELERGVKVRWVREGRGLDLDKDRLISLFSSYGEIENILLLKDKRQRIGDNREKKTVATAVVIFASIVSAHFAVLNSEKKMRQSVGQTDSEWSAIESVFWASGSQPDLSVAANSYSTASTPLEQGIAAPNSSGPNSSAAPPKPSFNFAGLKSAASDAAGKKPGKAPSFGSFAAGAASKSAQSAPAGSANGSSAPSMAELTLMRLRNAQREKERKALEEQLRKEDEAADAAEAGSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QS88</accession>
    <name>A0A8G1QS88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF4045 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_493747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825098">
        <property type="protein sequence ID" value="RAH51644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509566.1">
        <property type="nucleotide sequence ID" value="XM_025663845.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37167247"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025118">
        <property type="entry name" value="DUF4045"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057226">
        <property type="entry name" value="DUF7904"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF133">
        <property type="entry name" value="DUF4045 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13254">
        <property type="entry name" value="DUF4045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25480">
        <property type="entry name" value="DUF7904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4045" evidence="2">
        <location>
            <begin position="11"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7904" evidence="3">
        <location>
            <begin position="1940"/>
            <end position="2038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1204"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1284"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1445"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1503"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1791"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
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            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
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        <location>
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            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="757"/>
        </location>
    </feature>
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        <location>
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            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="962"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="976"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1299"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1559"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1653"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1697"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1724"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1741"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1764"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1796"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1810"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1834"/>
            <end position="1860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH51644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2301" mass="247304" checksum="B07E6735A55C136E" modified="2022-01-19" version="1">MSSTTDADGTEDVNDFLLRIRELGEKRDKEDEERTKKLEEEILQGRKERQARRAERARSISPTKDSPILDPARLSMSSFSQRAIDPPEHLEPTPHTPGHDTGNGADSVRDDASISTDNGRRGSTLTANDGETASRPISPFRSRAGTLSWQQRPTSRDSSRPFFSASPSRESRFRAMSTTSNDDHGVSRSPFASSPSFKDVPWSRHTEGGSPSPTRAKQVEEDSLHPLHPDTAVKESEANQEHTTESAKEAENNELVEERSRSPSRASSTFAESSLGNRYSSISSVSTATGLGSPLPLTSAQKLEPRKTEDGADDQITSPPSPRRLSPERSTSPTKGLGGFVQSAMMKRSDSVSKRWSAQLPSGLSRGNSISSNRNSFAAPSGSDVFSTAPSYRMSRDGASLSPSRPTSSHRPGSSHRPGSSHRPGSSHSEATVVHPVKDGERPATPPVPGSSGARLDEENRRPSLSLHTRSTSTVEKSTDSGSLPPSSPSVSRTMDPKRWSPTKASWLESALNRDESPRHKRQPSQQASWVKDRQSRGSVDLGRIASFKEVTPVGLMRTTAPGGHSKTSSITGIPDIFSNQDAGKTKEAEPETAVQGADTQDSALPPAEKTEDASPSKEESPTKTEAEPEKTEDGATKHKRTPSNLSPITKTTIDAPLASPRDPLLNRPKPLSPVIDFRANLRRREVVKDESPREEPEFKNIFGRLKKAESSKHVPPDELKENILKGKAALNSSGGPKKSQKVDELKDSILKQKEAIKASGGSLRRNTAGEKDAPGKFVPEAIAMRNNLTKSSSIKSNLSAADSSSPLSPLSPREPGTPKSTHGFQVASPLSPAGAEPLEKFQGSPIAPEPPKPGVDDTAEEAAQPKLPEPERECGHEKTDGAEVNAEEVKEEGINPVRSLPPGDLMQATSAPAETEGPAAKSKLAGRLNPALAGLLSRGPPAPINGSMKGPSFGSAGGSSSGVEGSQAGALTHLTKGRARGPKRRLPQGTTPEGTNSLFDESNHVPESPPTPLDAQRPESMYSETEEESDAPDMPAHVDVEKAEDMPLHTETTHALEPLTYMEEKTPEPASPVHEAITHAPELPEIVGKPESEPLSPLHKENTNTPELSSPIDEEPQPDSPVKEEMNYAPERSAPVHNDEPEPTTEFQEETHDAPVLSASKIEEPRPASPVNEEENHAPMVSAPIDKDERGPASLLQAEAHDVPALSAPKIEEPQPVSPVQKENDAPMVSAPIDKDECGPASPLRAEVHDVPVLSAPADKTETVPASPIRVEVNDIPVVSDELEPASPLQEAVLDTPAVKDEPEPASPIREEMNDVPVVSAPVDNGLPEPASPLQEEVHNASVVSDPVDNDKPEPVSPIHEVNPAPKLSAPLEKEATPAYPTYEENSDALVPPALMSKKKSEPASPIQEEINGAPVASASFCKDEPELVSPVQEEVHTAPVLNAPAGMSGLDATSPNQDKANGAPDLSTLLENEEAKPAIPVREGIIHEPEHLAFADGEKSEATNLALESPDASGLPGQAEEATLEVTSPILERKTYVPPSPVHMDTIETEATSPVYDETDEAQEMSASEDENRPSSSIVGVDEPPSASLDAHVPEPMVSAAEEKNGVLSPPSPKAEEPQTRSPAPEAGDAVPNSPSDLSVAHEPAPACPTSVHNIGTVKSPSLDAEFELPNSTSEVPEAIPKSPASTLDAQRSEAPVSPIGSPAGASGGWPLPNTEVKSNDEPQASPSQLDTPATSKPTEFKRSIPRLIERETPQKPDDTSPKPSTVLDQTATNIRENASAYFKSIRSSLSAKPPLPPKTAPLPATPVSNQTRASPTHFSSPSPSPLRASFRDNQSYTHPTQQRSASSLFSTIGSRNSSPRDKALPSPPVPPKGSRASVDRFSSRSSTSLVPQADESWEAISDFFKTFPKSSDRVNIDTQLMLADKSDNAKIRTLKRQLWEITGDGKKQDLPVNQEYILYEGSMYLCVHLFEADGTVRSEVHLWCGDDVPDSAVDDAQAFSRKVAKDNGSKLEIIKQGKEPARFIQALGGILITRRGLSSRSSSSAIFMLCGRKHLGQMVFDEVSFSPSNLSSGYPFVISAMFGKLFLWKGKGSSAEEIGAARLIGMDLGLTGEFEEVAEGEEPESFFEVFPHWERETGDTSTDYWRVKPNHERYRSRLFRIDHELGQRSGFWLRRSGSPSPVIRPNDTVQEIEPFCLKDITAKGVYVLDTFFEIYVIVGDQASNRPAEFASAVVLAHEYGILTASLQDRPFIPKSFVALGGVPESCSTAFRKWIPGYPSQRLPQVFPLNAAIEAIRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSR4</accession>
    <name>A0A8G1QSR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_463001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511528.1">
        <property type="nucleotide sequence ID" value="XM_025661888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSR4"/>
    <dbReference type="GeneID" id="37165290"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="388"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="504" mass="55187" checksum="BCACA342E6D68E23" modified="2022-01-19" version="1">MESVGVSHNSPEMVPPRNIQTPELPESGSVKDKIGKFSAYQQQPSSLKDAFGKTPVSIGANRPRTPQQIAAQLAAGRSTPGEIIATHTGVSRTQGSMPKPSKRSDDNEGPPLLAPKPVWATSANSASLDKLLHSEANLPIRDKSLQRRPVAQISPIEAAKLAAKKPRPPPVPRKPAAVVTGPTSVPINVHSKGPVNPEQTSKNHSSRPLEDTTIPSKAPPALPPRTGASSVPRKDLTNHRRLLESNHGSRTRPSTPGTASLYATSLSNSTTSLLDSSSGREEGAFSDAVVASSRASIRASQERKVPPPPPPERRARSRSIKRFPHTAKGEHTDSTSPSTHLRQTLREPTKIAEDDEGYQRHKHLLRKHPHKHHEGDRRRWRSEITEKERRRYEGVWAANKGLLLPPSHLRVPEAYPPECSEMVVNLVAADIWSRSRLPRHVLAQVWELVDGQHIGLLTREEFVVGMWLIDQQLKGHKLPPRVPASVWGSVKRISGVHIHGLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QSY5</accession>
    <name>A0A8G1QSY5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_523373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825075">
        <property type="protein sequence ID" value="RAH53711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511633.1">
        <property type="nucleotide sequence ID" value="XM_025665344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QSY5"/>
    <dbReference type="GeneID" id="37168746"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="227" mass="25189" checksum="5775A115607EB406" modified="2022-01-19" version="1">MPEAPNDSPSSWASRGSSFSPSLLPTVGAPLLSDYADLDAEHQGYSSMFSMIPTVQNGSQTQNRDHGGVHQDVHVHANRVSWSSGGPAMFWTPPMPATTPGSVQSTADYHRYTDVHQLPTNIMPEPYTEPIVNMRDAITGVGALNPGSGSIVWMPESIAEPRQNGQHCRWAGCTHTQPFRRPTDLVRHVATIHITPQSYQCPECRQRFNRGDNMSDHRMRVHNVRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTK8</accession>
    <name>A0A8G1QTK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_508341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825089">
        <property type="protein sequence ID" value="RAH52020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025509942.1">
        <property type="nucleotide sequence ID" value="XM_025664457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTK8"/>
    <dbReference type="GeneID" id="37167859"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="114" mass="12481" checksum="5E4EA47B44D81A98" modified="2022-01-19" version="1">MLRRFSSGATNNKGGWFQSLPFRDVKKLYATTSALFCASPRTHFASVQVCFGNTILGVLGGPCFYSLHNSTVAGENSDSAEPGRDHNQTNPAIFHATTASRGLPCRRDYESLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTL1</accession>
    <name>A0A8G1QTL1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hmg-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_492806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825082">
        <property type="protein sequence ID" value="RAH52681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510603.1">
        <property type="nucleotide sequence ID" value="XM_025663795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTL1"/>
    <dbReference type="GeneID" id="37167197"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="3" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="3" id="KW-1207">Sterol metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH52681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="389" mass="41217" checksum="8C4E906E1E16DD59" modified="2022-01-19" version="1">MSSQAPRTSNKFREVTKGLKEITAHPINSSHVHIENPIGSVQVPVGLAGPLLVREIGKAGEQKGEEVYAPLATTEAALVASCSRGCKAFSRSGGVHITSLSDTMTPAFKFDSPTDALLFAEQIPTFSSELKRIAESTSRHLRLLSVTPTVVGSEAHLKFNYACGDAAGQNMATIATHRACREMLLDPAVAQLLKVRGFLIEAGLSADKKGSWSHLMKPRGVEVMAWGSITNEAAKEVLGCTSEAMYQGISRLQSANIRAGVHGNSVNAMNIVTALFIATGQDVASIAEACWNQLVPEYNNETKVITLSLYIPSLPVAIVGGGTHLGPQREALELMNCSGPGKKGRLAALIAAFALALEVSTAGALHTDTFTQAHKGLRRKPDDGNNAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTL7</accession>
    <name>A0A8G1QTL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_452453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000249526">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Dimeric alpha+beta barrel"/>
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            <begin position="4"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH54056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="107" mass="12313" checksum="04FFB1A8149D3EF0" modified="2022-01-19" version="1">MAEAQLIATLRPAPGKETEVRHLLCDTARLVEQAEPSCLAFLLTEHHRVDGTLEFRVIERWANINALEHHHSRPWLRQMYSTFLEKQLLDGPEQIEMLTVIAGFAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTN5</accession>
    <name>A0A8G1QTN5_9EURO</name>
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            <fullName evidence="6">C6 transcription factor</fullName>
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    </protein>
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        <name evidence="6" type="ORF">BO85DRAFT_454081</name>
    </gene>
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        <name type="scientific">Aspergillus piperis CBS 112811</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825085">
        <property type="protein sequence ID" value="RAH52379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510301.1">
        <property type="nucleotide sequence ID" value="XM_025661195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QTN5"/>
    <dbReference type="GeneID" id="37164597"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA-templated transcription"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="152"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
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        </location>
    </feature>
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        <location>
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    </feature>
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            <begin position="608"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RAH52379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QTT1</accession>
    <name>A0A8G1QTT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_201005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="RAH52439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_025654535.1"/>
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    <dbReference type="GeneID" id="37157937"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="157" mass="17665" checksum="7E14C63130B25A17" modified="2022-01-19" version="1">MRGHSNQCCVWACLGMATIPMLRQFSMEVKLACASHLFGIGDEIGQCDQRGHDTLEGILVLVGCPFPEIEGERAVPREPTPVLQGTPVLGETDQDDQLWAALRSNQRAVECRKLLVQPMSSGLFRPRPLPSLHRRPLDRERYSTRQRSTARWGRCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QU75</accession>
    <name>A0A8G1QU75_9EURO</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BO85DRAFT_454029</name>
    </gene>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825085">
        <property type="protein sequence ID" value="RAH52320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH52320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="65" mass="7003" checksum="9F81521769F673CF" modified="2022-01-19" version="1">MGTTLGDGNHQWAIRSVGNITVAWSSTYISALLFGTYVARPLLLVSFSSRYLCLTDGQIIPAGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUF8</accession>
    <name>A0A8G1QUF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO85DRAFT_429763</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511083.1">
        <property type="nucleotide sequence ID" value="XM_025658264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUF8"/>
    <dbReference type="GeneID" id="37161666"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="12">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAH53161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="319" mass="34796" checksum="02CAB4CF2AD53F1B" modified="2022-01-19" version="1">MGSTSTVADTRFKLNTGAEIPALGLGTWQSGPGEVEKAVAHAISVGYRHIDTAFAYGNEGEVGKGIKAAIESGVVKREELFVTTKLWSTWHYRVEQALDQSLKNLGLDYVDLYLVHWPVAMNPNGNHPNIPTLPDGSRDLHLNHSHINTWKDMEKLVGSGKTKAIGVCNYSRPYLEDLLAQATVIPAVNQIENHPCLPQQEAVDFCKEKGIHITAYSPLGSTGSPLLTAEPIVEVAKKKGVDPATVLLSWHISRGSSVLAKSVNPSRIEGNRNLVALDDADMATIAKYTNDLASKNAFQRFVFPPFKLDFGFPDKIGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QUH0</accession>
    <name>A0A8G1QUH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_452725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825074">
        <property type="protein sequence ID" value="RAH53883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511805.1">
        <property type="nucleotide sequence ID" value="XM_025660897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QUH0"/>
    <dbReference type="GeneID" id="37164299"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH53883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="863" mass="95408" checksum="514FE5BD6A8521CC" modified="2022-01-19" version="1">MDSSEKGHTKRQRRSSLSQQLQRVFHLDKHVNKERRRRSSDSIEARTIRTPGQERERTQQTDEVGLGGSTSRSASFIRTNEDVGPRIAQGPTFPGLVDNELVKSSAHTTSQGTLQLSDSSSVMDMSSGKHGSFSPATSINKATDRNERRATRRLEAERLELEKRFLNLEKSEQRHGISQQQKESRRLTKKQPIRSSSRASSVSEDESRPSRRFSSLFSSSRRGSRSRSNSLSRSDADYPTDAERSQSGLHSGPHAARSHIAVKMPNRFGAVISKELSINNALAPYKPEPAPTRELMPANPTSTESKANDSTGPDPRSIENNLSHGQSPVQDHLVSVDKNAHRVASKAPSLPVPTDLDRLSFAATLNLKSRESGNVRLSGHRRSLTVSSPELLNKREKHTRGSYKSTRIAQVAADGGKTSRSSLGLSSTNLQANSLRAAPNRTSTDRYLQRQYKSYVSSPLTVASTVDSRSNLSSNAKETSNTTTLQAPIEDKSNPMDSIKAIDSKYKRTHPHVTRRLSGRYEDKDEGDLTQPHSMVGNPQERSVVGYTWASHHLQTSSSKRTLTNQDEAHAVTCREPGVEKSDSRTHNTNGSLTDLDVYQAKHAGRDGHLESQDTPPRYRTQACQNLAQSFQGAPRMQRPEACHMPYESKLTQRRGSISSISASSEEPRSEDYNTADEACSSISLPRQDGITPASFPHTDYTVPSTLDNNDNDVSLSVGASTSNLCNTPEGRMNGRIEQLRNVQTVGPFKMLFVICCHCGHWHDLPSRMRAKLTSPSTSSVAKEHKLSTDKGEPRAGQECIDSKIRKNSFSGQCVDSSSTESPASAARSQSPTTVQCCWCNHRMDRSCCQGWTTIIRMCERHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QV94</accession>
    <name>A0A8G1QV94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitrilase</fullName>
            <ecNumber evidence="4">3.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_522848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a nitrile + 2 H2O = a carboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18379"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="EC" id="3.5.5.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.5.1" evidence="4"/>
    <dbReference type="EMBL" id="KZ825072">
        <property type="protein sequence ID" value="RAH54478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025512400.1">
        <property type="nucleotide sequence ID" value="XM_025665300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QV94"/>
    <dbReference type="GeneID" id="37168702"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF14">
        <property type="entry name" value="ARYLACETONITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00921">
        <property type="entry name" value="NITRIL_CHT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH54478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="320" mass="35972" checksum="8C2A110C6B12D124" modified="2022-01-19" version="1">MSHDGPKTIRVAAVQAEPEWNNLQKGVEKTIRLIIEAGKNGANVMGFPEVWIPGYPWSIWNQSVVDNVEFMVEYFRNSLERDSEEMNRIRCAVKEAGIFCVLGYSERYQGSLYISQSFIDENGDIVHHRRKIKPTHVERGFWGEGQADSLKSVVKSSFGNIGGLNCWEHTQTLLRYYEYAQNVDIHIASWPLIFGACAEMQYHISSEMCGKLTQVMSMEGACFTLICSQVMSAENCERNKVDKWSFVKAPGGGFSMIYGPAGEPLVEAPDAGEEVILYADVELAEKWRAKQNLDVVGHYSRPDLLSLKVTNNAASQVHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QVD9</accession>
    <name>A0A8G1QVD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pantothenate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_454202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825087">
        <property type="protein sequence ID" value="RAH52135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025510057.1">
        <property type="nucleotide sequence ID" value="XM_025661223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QVD9"/>
    <dbReference type="GeneID" id="37164625"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24123">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000115">
        <property type="entry name" value="Pantothenate kinase PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.510:FF:000005">
        <property type="entry name" value="Probable pantothenate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH52135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="439" mass="48472" checksum="5A50E7540F31D4A7" modified="2022-01-19" version="1">MSSSTSNSAARGGRLEQAITNPGSVKINVKGAFIVDDDPRSKSPVRTDGVHYEGHDIRLPHHTGLVSHVAVDIGGSLAKLVYFTRELDSVDNGGRLNFINFETSRIDLCIDFIKQLKEEHEKLGGPSGDALCVMATGGGAFKYYDKLKEALNVDIIREDEMECLITGLDFFITEIPNEVFTYSETEPMQFAEARPDVYPYLLVNIGSGVSMIKVSGPKQFQRVGGTHLGGGTFWGIMSLLTGARTFDDMLAMADRGDNSGVDMLVGDIYGMDYSKIGLKNTAIASTFGKVFRMKNQTEPNDLEGESSSNGEAGRTNGEPKFQHEDMSRSLLYAISNNIGQIAYLQSEKHQVKHIYFGGSFIRGHRQTMNTLSYAIKFWSKGEKQAYFLRHEGYIGAVGVFLRRQPANWGRRNSIDEKTMPQVAKLVAEAQQNSDSQNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWC2</accession>
    <name>A0A8G1QWC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_471286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511964.1">
        <property type="nucleotide sequence ID" value="XM_025662466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWC2"/>
    <dbReference type="GeneID" id="37165868"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050583">
        <property type="entry name" value="Mycobacterial_A85_antigen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48098">
        <property type="entry name" value="ENTEROCHELIN ESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH54042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="312" mass="35264" checksum="2F058DD73B38C66C" modified="2022-01-19" version="1">MTVIDKPDEVYPPIPVYGGRWTPPKRLLDCYNHMWIDTDVWELPENVTYELYSQPTRGPGAQGSYLVVLPPGYDDLDVNGERYPVLYWLHGGFSCSRHALWSLQFYARKMELGTMPKVILVAPQALPKGRWINSYDGSRRLGDIMRHDLVTAIDERYRTIRHPSARWLEGHSAGGYGAFNLGLKYPDVFGGALSSLAGSFRTELAKEGFEVTYDTYNGSQEFFTSNHALTLLKGILPRVHRDKPELRLLIGGEDIRLREAHEHMWTSLDVLGVPYTKAIVPGAPHTAEHVLGGLNNDGLQFWWNARAKVVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWE8</accession>
    <name>A0A8G1QWE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor 4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_442407</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825077">
        <property type="protein sequence ID" value="RAH53415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511337.1">
        <property type="nucleotide sequence ID" value="XM_025658838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWE8"/>
    <dbReference type="GeneID" id="37162240"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000356">
        <property type="entry name" value="Translation initiation factor 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="82"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH53415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="505" mass="54762" checksum="FABD90093F76FF0D" modified="2022-01-19" version="1">MAPSKQKAQKMSLGNFLADERTDFGSWADEMEDMPLPSAPAPSSFGRSAAPSSGFGSSFGGERERGGYAVREPLPLPTQPPYTAHVGNLSFDATAADISDLFADCGVTNVRIVEDKLTKAPKGFGYVEFETVDGLKKALDLSGATLQGRSIRTSIAEPRRCPFSAKERDVKEFDWTRRGPLPDIPQRRVPDRSSFGRNLDNMSDAGSDRGSGRRSNFESDGKFRDFSNWERKGPLSPPPAPVREGGRPRSNEAPGFRRSSPAWGEGRSQDGSRPPRREFQERTPTAAELDNAWRSKMRPDQPAKEASNPPSPAAAPAAPATRPRLNLQKRTVTEAVSSPTANTESKASPFGGARPIDTAAREKEVEERRQIAIRQKKEADEKAKAEKTEKSEKTEKQRPAKEQPKAEKTGAPADPNGRDVAEHAQGGTNFEILRRAGEDESGMTADQDQSEEAAAKKAEASTDAPASKANGNWRAGPAEAGADDEGWSTVSSKQRNNRRGGRTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWH4</accession>
    <name>A0A8G1QWH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_425574</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825068">
        <property type="protein sequence ID" value="RAH55691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513613.1">
        <property type="nucleotide sequence ID" value="XM_025658081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWH4"/>
    <dbReference type="GeneID" id="37161483"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23513">
        <property type="entry name" value="INTEGRAL MEMBRANE EFFLUX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23513:SF6">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH55691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="57855" checksum="1676E6DDBE5539D9" modified="2022-01-19" version="1">MGLFKSVRNGWNDFTPKERREAACYILGITFYKFGLEAFNGSIITLATNRYDYDALRANMPPKTFQRVGLMVGLNQACQCVGSILMAPLIRRYPARLILMAAMLAFGIFSAILLIIDACTGGTFVPAAFRPHHPQNDFHYYGRYNTDSIIPIYCVSGFSYGMVELIRRIIPRDIVGGNLKRLRRLDALVHIFYEVSGTAGAFCTALALIPHLGNNYSFLVTPICFTLAAIVWSFLGDDVFKAHKAAEPPDQTTYIRAALRGIKLFLESIWVGARIIFTTRKFIWLLPGYSIALYAHRYLESAVMPALARRYLGNAAWSQIMVGGSNLGELFGAVFVIFLNNRVRTPMPWLRVDALMLLITWYLPFWKPPVRRVRDALFAALSFVPVSFGWAAGDVSLAAYIQATLTRMESTSKNVSALGAVMAFLYSTYIVLYAITSPLLGSYIDRVYVETGGPVGGGDIHLAIRNVASVQLSVISLLVLVSSFVPRGSLALSPVALDDEDLEEEDWGNDVLSSKASVVSLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QWJ7</accession>
    <name>A0A8G1QWJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_481018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825076">
        <property type="protein sequence ID" value="RAH53490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511412.1">
        <property type="nucleotide sequence ID" value="XM_025663042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QWJ7"/>
    <dbReference type="GeneID" id="37166444"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH53490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="638" mass="69060" checksum="349F829629231BA5" modified="2022-01-19" version="1">MAESDTVVSVASDPTSSNPKKDPKAKEEKIGITSHWIFIIWSWFLLTIPLSSLTAVFLALVFSYRVDHGDSPFENLRVGLATEGSSDAYYVNMNSSILLFVTSWASTLAPMLSGFLITLASFPIARRYLQDIRQGRFERLPTPYQLTLMLKFFDGGTLGATWSWVVYLVSWKKKRQPQTSTLFSAASVALLATLLGALVSLADTWLHLTTTTVSFTRATAATDNTDYGFGLTAQCLKGNNSVAAQEDTGLCSVSMAVTGQFLANATVSLGVLNNVSDFATVYTYDNNSTMYSYLGLPEGTASVADRDYEAQTYGAATQCEMFSKRCNLTEVTTSLRYNCSSAFAGFIDSTELITGFFTDSSMTTDIEDNETSNYGTGNPFYYVIAGVLSTSGGTVPNSTEFVQNESGVYGYVLGCNTTIYDIVYDRVNNSVTRFVPTDSNTSVSNIWQTSIAQTVDWEPSIELEIGAAAFSQSGQEFAVKIAQSFSKVILALGADGIESRPALAAQQRETSLVSRVPMAPLFTLVAVDFLYVIVGLIFAGIAISTARGAVPDVHARLGISGLVADRFEEPGSRKEVHSVDEMFEEYAGQPSRRVAVEPETEGGVYVFKNWDTSRSTSADVREGSVAVERSGLIGSESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QX08</accession>
    <name>A0A8G1QX08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NRPS-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_498887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825069">
        <property type="protein sequence ID" value="RAH55127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513049.1">
        <property type="nucleotide sequence ID" value="XM_025664040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QX08"/>
    <dbReference type="GeneID" id="37167442"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="557"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH55127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1063" mass="119270" checksum="1220978CBB505DE0" modified="2022-01-19" version="1">MGSADVSGRLLTQLVDQQAKDQPDRLYCLHPSSQDADCEWLCITFHQLSAAVNRVAWWINSRLLGRKQQILAYIGTNDLRYLVFELACMKTGHAALLLSTRNSQAAFHHLLSKTNCSVLVDGSERPQLKKVVDQVELACSDLGLERWRMDPVWDVFAASPVKPYPHRENFADIEDRPAIIIHSSGTTGLPKPVTLTHGYLATMDQMQTLPVPQGRESAQLFLRHKGEMRFCHGPLFHFIGIVCVFECIFYETPFLLSPDRPLTPDLFSRIMATPDPPRWCLIAPFALQELWSSEKGRQAIQGFSAVNFGGAPLSSTTGNAISSHVRLQTLMGSSETGYTPTLLCEDPADWDCFEWNPAFEHHMEEVGDGLWELVIPRPSSRRYHAIFHAFPNLSEYRTGDLFEPHPTKPHLWRSKGRADDIIVLNNGEKLNPIDAEHLLESHSLIHRAAIFGQNRFQVALLVQPQWDELPETWTPQWLKQALEPFVKNANGLLPAHGQIHHNRIAVAFRDRPFALAPKGSLRRRETAQLYEDVINALYSEAAGNEGSINDVEKLQESTMEGIELWLQEAVSRILGGISVELDADIVSLGMDSLQVVRLAQALQDAADRMRQSKQRAALWTSAVIYEQATVRRLASTLFRQLHGHLEAEGEKHTSSFWPREHQLTHAIWQQAQNLQLSGKTILLTGSTGELGSYLLEELLQDPTVAKVYCLNRSADAESRQLARFREKRLADGWLVDTSRVKFWQAELSQERLGLTADEYSYLREQVDIVFHNAWMVNFNLPLSSFRSQLEGTGRLLNLIKGSPRQAAFHFISSIAAVSGRPTIVPETDHIAETLHGPSIVLIQGYAESKYAAEVLCDLVARETKQKIAVHRVGQLGGPTDAEAGMWTTRDWFPALVRTSQTMKELPDSIGSIPVDWVPIDVAARSIVQIACGRHNERLASTGLNNAEVYHITNPHLGNWEPLAQVISQVCSSRIIPLKEWVQNLTDRVSDLKLNEEALLEIPAASLLGFFRSLADSEGWKRPPADTTNAQKYSAALGALGPVDASLMKVWLQQWSDWIPELRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXG0</accession>
    <name>A0A8G1QXG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_472021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825078">
        <property type="protein sequence ID" value="RAH53155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511077.1">
        <property type="nucleotide sequence ID" value="XM_025662528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXG0"/>
    <dbReference type="GeneID" id="37165930"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="31"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH53155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="357" mass="39906" checksum="DF791C2D4298A83B" modified="2022-01-19" version="1">MSFQSISYNAGPGILALNWTAAAIAILVMILRVIAKLRIRHYAVNDTAMLCALVLALAASIMITLAIAHGYGRHFWFLSQADQVLALKYYTGFQCLSIIATGAGRAAFTLYLLNILRQERYLGWILWFIFALQIIINIVSVATILAQCQDVNSLWDVRVTTTCWDPNVERIYGYNEDTDRYDKAINTASDLFLAVFPTYTFWSLSLKLRVKISLVVLMGFGLVAMVASIMRIVHLGSIAERGDPTAVTVQLTRWALAECYLVIITASMPCIRSLIIASVRNISSGNRSRVVGSQYKISPPIPNRAEYSTWADAPPPHSREYILSSYPMERERIGGRVITKQVDITVIRNRSRSTRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXM3</accession>
    <name>A0A8G1QXM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_441514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511952.1">
        <property type="nucleotide sequence ID" value="XM_025658809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXM3"/>
    <dbReference type="GeneID" id="37162211"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="79"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH54030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="386" mass="42961" checksum="CCC3CBE60452424E" modified="2022-01-19" version="1">MAFESLAFHTKLRILRWLTRLLAWLDRKRHPVSTITPTSQISIPSTLSASPGNFDLHIYHPPGYNQSSTEKGEAPYPVVIVLHGGGWCVGHARHDERFIETVTQRGRAVVVAVNYRLAPEHAYPVPLLDCVDAMLYIWKNATAMGVDKHRTFITGFSVGGQMAFASQYWLAQALAQHEHPQIDRASLGTVKAITAFYPPMDLTKTRAQRAASNPAFMALKKKPASSSKLIGDIFDRAYFWNLPDTIDKSQICISPGLAPLEMMSRALPNHIYVKLAGLDPLLAEGKAAAAQFEAAGKHVECEVVENVPHYWDHLGKTEHEKTLRSRVYEKAADEMEEVLRNVNKLQGKLFGPRTWETGTSTSSLILLVAIENSSVRGDACFKICQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QXQ3</accession>
    <name>A0A8G1QXQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nitrogen assimilation transcription factor NirA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_452471</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825073">
        <property type="protein sequence ID" value="RAH54075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025511997.1">
        <property type="nucleotide sequence ID" value="XM_025660828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QXQ3"/>
    <dbReference type="GeneID" id="37164230"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF86">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH54075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="708" mass="79273" checksum="7712FB20BF6207E3" modified="2022-01-19" version="1">MSPKRQSSPTTPRACQFCRVRKIRCDNEKPTCGSCQRHDRQCVYVVDPPRQRPSRALINAAHRQRRAAENVIIALKKADPVARAAILDSIHVKDGVLQLPASLAGLGANINDPPVSQPTQASDNSSNVYSTPNDELNDSSSEDEDYDPTTFLSHDECGTVGIFGPSSALHARSPLGLANSANSRPAAEPDRYQLIAEAALQRQREPDLRRLPTIGGIPSELALHLLDLHWNRQHHTFLLTYRPAFMRDLVTGGPYCSDFLLNAVFACSSKFSTRVEVREDPQRPESAGKRFFDRCDQLLAEQSLLTHSSIPTIAGLIMLGSTFNARGQTSKGWLYTGFALRMVYDLGLHLDCKEVAASAEDIEVRRRVFWAAFICDKLQSLYFGRPFTIQLRDAHVSRDFMDTFEENELWMPYIDPLKPDSTARSHIPTRIYSVTVFQQLCSLSKIMTSIIDRFYMAGATGNKTRKHLELIDRRLEAWYRKLPAELQFEPWADDGQSPHATVAPNVIILLTTYNALIILLHRPFMGSGHLRSDDPPADSWERCVTAARNITSLALAYRTAYSLRRANYMLSYAVYVACTIHARNPAIRESTRRKEASSPLTVCLRCLDELAIPNCGVSAPSKIIRRLMEANGMSIQTGCDPAIQDPFQVDINLDFQTFPGLDFSPARLDHANQISGFQDFNQDLDLLFGFMNEPDVSISSMFTGVVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYC3</accession>
    <name>A0A8G1QYC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_498378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ825067">
        <property type="protein sequence ID" value="RAH55959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025513881.1">
        <property type="nucleotide sequence ID" value="XM_025664032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYC3"/>
    <dbReference type="GeneID" id="37167434"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF33">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH55959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="273" mass="30831" checksum="DDA87458851BC061" modified="2022-01-19" version="1">MSSDYKLYDYEPSVVAAIISAGLFAATSLVHLFQLILETFGYIARYFSARETPDWTVKPYVGQELLLLLAPALFSASIYMILGRIIRLLDGSSHSLIRPSWLTKIFVTGDVLSFFIQSGGGGMMASAKTPSKISLGNNIIVVGLIVQLVFFGFFIIVTVVFHRRMAASPTEVSLTFTPPWHTYMRILYTASVLIMIRSIYRVVEYVQGSEGVLKQSEMFLYIFDTLLMFLCCVLFNVMHPSRILSARPKSYGKMMDMEEDQVEMLRPEAMKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYR6</accession>
    <name>A0A8G1QYR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_439888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514106.1">
        <property type="nucleotide sequence ID" value="XM_025658736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYR6"/>
    <dbReference type="GeneID" id="37162138"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH56184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="209" mass="22587" checksum="2E9B1DCD96878AEB" modified="2022-01-19" version="1">MYPFLPWSQNQSSVRSSLSEATTSTQNVSFSFSFGSSCSPTSMPPPPPPSPTDSLLDITPRKCSFSSGYEMNNSCAFPSWPNRPSLLSADSEGSSASAYLSDEDLLPIGSGSPCESAIDEESAAQDPTMGDVDLTTEQQIQMIRAAAEEEAQRARFLAQVQAHARAQQAMRVAQMAAAERENAKRKKRKAIPERKRRTASASKATVCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QYY7</accession>
    <name>A0A8G1QYY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_497306</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514425.1">
        <property type="nucleotide sequence ID" value="XM_025663990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QYY7"/>
    <dbReference type="GeneID" id="37167392"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF172">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH56503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="507" mass="57818" checksum="098E36ACF8BA1CEB" modified="2022-01-19" version="1">MYKEIIVVFRILIVLKAVLPPIYTYLRDPKGLKRFPGVSVAPLTNLWGVWKQYLCTRTVAVHKAHLKYGSIVRVGPTHLSFSTPEAIRDIYGHGTPALKDDFYQTFDSTHLNVSDAQDRDIHNIKRKRFANAFSQKRIGELEHVVQDHLQRVFRILDSSKGEEVDMKQIMMHLMYNLIFDNFFHHDPHFIERGSTSVTIKTPSVSPYKGEIHHLLSSALHISTSLGWAPKARAMLKHLTCWHPGWKHGTQLQHITTHFVRERVNMDIERVDAGLPPLDDLMATLLWDRNREHPLCLELGELVTEAQNLFSAAGGNTEIALTNIIWYLANNKHVVRHLRAELADALPPHNNSSSPIPYDLVKNLPYLRACIDEGLRLRPSIPGGLPRVVPKGGMMVSGEWLEEGTTVSVSTYTVHRDPDIFGLDPERYIPERWLQPGSRDMQRGFLAFSQGGRGCLGRNIAYFQMQLVIAALVWRYDLTLREEGWELETMETFSAHTGSLPVVVTRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1QZB4</accession>
    <name>A0A8G1QZB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cellulase</fullName>
            <ecNumber evidence="4">3.2.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Carboxymethylcellulase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Cellulase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Endo-beta-1,4-mannanase F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO85DRAFT_374872</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan. Involved in the degradation of complex natural cellulosic substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="4"/>
    <dbReference type="EMBL" id="KZ825065">
        <property type="protein sequence ID" value="RAH56403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514325.1">
        <property type="nucleotide sequence ID" value="XM_025656144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1QZB4"/>
    <dbReference type="SMR" id="A0A8G1QZB4"/>
    <dbReference type="GeneID" id="37159546"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000078">
        <property type="entry name" value="Endo-beta-1,4-glucanase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034850791" description="cellulase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="15">
        <location>
            <begin position="489"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAH56403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="527" mass="55627" checksum="3581D2DD18860F15" modified="2022-01-19" version="1">MRISNLIVAASAATMVSALPSRQMKKRDSGFKWVGTSESGAEFGSALPGTLGTDYTWPETSKIQVLRNKGMNIFRIPFLMERLTPDGLTGSFASTYLSDLKSTVEFVTNSGAYAVLDPHNYGRFDGSIIESTSDFKTWWKNVATEFADNDKVIFDTNNEYHDMEQSLVLNLNQAAINGIRAAGATTQYIFVEGNAYTGAWDWTTYNDDLSGLTDSEDKIIYEMHQYLDSDSSGTSETCVSSTIGKERIEKATEWLKTNNKQGIIGEFAGGVNSVCEEAVEGMLAYMSENSDVWVGASWWSAGPWWGTYMYSLEPTDGTAYSTYLPILEKYFPSGDASSSSSASASVAAATSAVSTTTAAFEQTTTPATQVEIASSSSSSSAVAASQTTLSKVKSKSKSPCKLSSATSSAVSSAAAVTTPAVAATTPVVVATTPAAAPTSLSVAFATTSVYVPTTTAAAPSQVSSSAAASSSGVVGVSDPQGPSATNSAGEVNQYYQCGGINWTGPTVCASPYTCKVQNDYYYQCVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0M2</accession>
    <name>A0A8G1R0M2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_450733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825066">
        <property type="protein sequence ID" value="RAH56084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514006.1">
        <property type="nucleotide sequence ID" value="XM_025660447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0M2"/>
    <dbReference type="GeneID" id="37163849"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF285">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="418"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH56084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="452" mass="49838" checksum="FBE05D6F7799956C" modified="2022-01-19" version="1">MPIPIITTAITEGTNSIPHLWSILKLLPWAVILAALKYYFGGARNTSERLMHSKVVMITGGTSGIGAQVTSALASRGAQIILLTQHPATDIFLSEYIEDLRRSTNNQLIYAEQVDLSSLHSIRTFATKWIDNVPPRRLDMVILCGNAAPPVSQKRKLTVDGIDEEWMVNYLANFHLLSILSPALRAQPAHRDVRVVFTTCSSYIGAKWDLRQVEEAAAITAAAAAAQQQGDNGGGGSNGDGRRVVMKNGKLQREKAKPKAAKKAAKGVSLYGLSKLSLMVFAQSFQKHLNAFKRPDNQPCSARVIMVDPGFSRTPGMRRWMTGGSLWGLLVYLVTWPVWWLVLKSPQQGAQSVLYAAMEAEYGRGEGGWMIKECKEVDLARKEVKDEEAGKMLWEFSEKLIEVKERESAVRRALANKEKEVAEQMEKNKASGSSSSGAKEQTPGSRRSRKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0N5</accession>
    <name>A0A8G1R0N5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_488693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515126.1">
        <property type="nucleotide sequence ID" value="XM_025663553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0N5"/>
    <dbReference type="GeneID" id="37166955"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF22">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="174"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH57204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="603" mass="65946" checksum="A866D1C5C7093F80" modified="2022-01-19" version="1">MALAVPDRILDLPTAPGQIFASCVLLPRLSQLSPSPSSSPLLPRASGAAGASFLQGPAPTAVFAVWSPLGAPNVVVVRPIAAPARRCDVAVSAFRRAVRQPRGSGRRGGESAQPAAAAPSFFARIWGALFRTGKMTVFLLKSALEDIFSERFVLAPGQSAYKNLNDSHSSATESEFEPGCIFCPRNTTDVSRFLSIVKPFTDREEIRFAVRSGGQQTTHACANLDNGITVDLKLLQGIELRDGIVRIKAGERWGNVYDFLAGHGLAVAGPLSTESGIGGVTLGGGLSLFSSREGFVCDNVVNFQVVLANGTIVNANPKTNSDLWEALRGGGNNFGIVTRYDMRTFPQGSLFGGSLWYECCGFPLQIKALMKVLQTSAVPKALRPFMEMSYEVQELRSVGMVSVPEAVASVQQRQSLGPGVEMESWSQKPDVNKRDRRQTRCAYMNTTVKADEDTLLKIFREFFEVVDPVRFTKGLRLSMSFQPYPVSLMRKSKELGGNVLGLHRGDGPLIGILLLAYWDNKEQDGVVLDSMKLLLGRIEDEAVSRDPIGSYGPRNNQRLQEVSRKYDPSGMFQRAVPGGFKLMDHYWMGGDPYFQFPYISYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R0R7</accession>
    <name>A0A8G1R0R7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_449837</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825063">
        <property type="protein sequence ID" value="RAH57123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515045.1">
        <property type="nucleotide sequence ID" value="XM_025660247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R0R7"/>
    <dbReference type="GeneID" id="37163649"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000561">
        <property type="entry name" value="Putative WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="362"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="405"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="516"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH57123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="624" mass="66592" checksum="0D7AB0EE96D8B9D6" modified="2022-01-19" version="1">MSNPTQPYDARRATSYGRPEELHIPSTGPNLQRQSMSHEYPAGQDNHVPSINVHPLGSQPGQYGGGGSSGASGVLPGALQPGNVNRPPAVSVNTAPSALPTLPELNTPMQPTSQSGQQPQSAQQQQPPQQQQPNARASMVNSHGHSRSSPAGFEQPKYRQPGSSPGSAYPPHTPQGTKYSPLGLADIRPTGDLLGDPITSSGMAPFNGDNPVPTNSNYIAPWPIYSMDWCKWPITGSSSSFGGKIALGSYLEDNHNYIQIIDTHWTQPDPDTPDAAAGEIKLDYVKTAEATHSYPVTRILWEPPSSQKQSTDLLATSGDHLRLWSLPTAQPVPSSNSITRSASQHAPTAKLSPLALLSNSKSPEHTAPITSLDWNTISPSLIITSSIDTTCTIWDIPTLTAKTQLIAHDKEVYDVRFCANSVDVFVSCGADGSVRMFDLRSLEHSTIIYEPTEKHEKVPTPGNGSPSGQAQPVWPPPLLRIAASPHDSHLLATFSQDSNIVRVLDVRQPGQALLELKGHGSSINCVEWSPNRRGVLASGADDCFVLLWDLINQHNAAPVPPMPPAPHNAGTPATPSERGPAAVWLCDNEVSNISWSPQGGTTPAGHPRDWLGVCGGRGLWGVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R1F5</accession>
    <name>A0A8G1R1F5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromatin remodeling complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_302175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515405.1">
        <property type="nucleotide sequence ID" value="XM_025655353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R1F5"/>
    <dbReference type="GeneID" id="37158755"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="6">
        <location>
            <begin position="455"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH57483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="738" mass="84670" checksum="96753BCDD9DF462C" modified="2022-01-19" version="1">MSSQTPRTSLREGLRQAPKANQPFIPDTAPVRRSHHNSNQSPQPSSMSQTHSNSPAPNSNNSHLPTEGWDGKEQKVPMNTREVATPGNRPGLFLTVPGKVAKQPDFYDPYFPLRYLEVPKSDHIYKRAHYGLQSGISDEVDFALYHLVQISNQRWDKFKFEGFPLLAETLMEKAIDVSIICTGVKWELQYEYRYPMERVNVLNSLHGTRDLLERIKRIPVTLPNDTLETYEFNHRLRNVKEATLVLRNMVLLPDNAFYVSRYAKGLLRDFLVILLNLPNQPRLNEIKNDALDIAEEVTKFLRTDPEDPLWISLLQCLESPDRAHVVRALWALTHFSTEINDSEGNQALERMPKQALQQMYFHTLLDLDKDILSGALDFWYQYTLSRENIETMLDIFDFPSVFVPRMIALLTHEARPSKKETVLQEEKVAPPPSEIPRVPAELLKDLMELQEPERSSRWLRCCFVEDAECEITQIALWQAYQSRFADPRVPGGGVLPAAEFIKNVSTTFTNAQAQVINGPGAATRFIIKGIRPLETAYTFQGFPYQYCKWADNSKPSKTCQRAFTTPTDLRNHVFADHMELKPTDTPGHYNLDNAESPVHTCLWDNCTRFRSSGPSNNTAMVAGHVASHLPEERPADAEPPVSKRAVLQERIVRKWFYMDTPVNERGEPFGVAYKAALVLRNIARNLPTGMAHKYNGLSWKKAVFLSHRPKIVETWDRNRSLRKELTELIMIIEKEDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R258</accession>
    <name>A0A8G1R258_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO85DRAFT_520977</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825064">
        <property type="protein sequence ID" value="RAH56879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025514801.1">
        <property type="nucleotide sequence ID" value="XM_025665181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R258"/>
    <dbReference type="GeneID" id="37168583"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF2">
        <property type="entry name" value="PROTEIN YTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034067130" evidence="3">
        <location>
            <begin position="27"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="4">
        <location>
            <begin position="32"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="5">
        <location>
            <begin position="158"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAH56879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="501" mass="54959" checksum="D22D164D6EF9F308" modified="2022-01-19" version="1">MAILSRFGPQGLLAVLLLASPALAHGGHESVPEGAAISEDPIDTTLWIHMILMGFAFGIIFPLGMVLGIVRSRWHVPLQIVGTIIAVLAYFLGHAHKGRQFSKNVHASFANTLMLMMVVQIVLGVYLKLHLSKGIHGRIRRAIVIAHGVVGKAMPVASWVQMLFGGITAMGFCRDDHLGQCLAHFIMGSAFIAYGILLTILLLVGQYWLRRTGRSQEFFDSLIIAAWGCVNTFTEHRWGGPWVHNDLQHTTMGVVWWCAGLLGIWMSRKRNGRPKRNLIPAIVILLTGYAMSAHPQTLMISTMIHSIFGYTLMAAGFTRIVEISFVLRDKGSVSPDGSDPNSFQYLTPFLLYASGFLFMGATEEQMQLLNDAGITHVSYVLILYSIAFILFLFVNVLLHIYAVHAWPESAQAPSHSRSSSAADAGEGSSRYRPAANGRLMNGHARSPSEAQHLHDAEEFELQGLISDEEDDAKDTHAMGPRKTEDEENSPLVANGTAATTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R332</accession>
    <name>A0A8G1R332_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vps52-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_468298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516600.1">
        <property type="nucleotide sequence ID" value="XM_025662252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R332"/>
    <dbReference type="GeneID" id="37165654"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="8">
        <location>
            <begin position="157"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="9">
        <location>
            <begin position="345"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="660"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH58678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1031" mass="112741" checksum="463EC29837F131E5" modified="2022-01-19" version="1">MWLDRISGHATPSGPQFDSRSSSPLPRRTSSRLAPAQNNRPASSRQGSALSLLSTPNDSSTSLAATARESSSPKPSAARPRPSDVADPLEVLNGIIGKQGKTRDSSPASVAEVKPSELVEDIDFHGLSLEDFIAEEEQPRRAWQSDVGAQTIQQFEKERDKFQDLHSAITGCDDVSKSVEMYLNDFQNELGAVSAEIESLQSRSIQLNAMLENRRNVEQLLGPAVEEISLSPKTVRLVAEGPIDENWVKALNEIETRTASIEAKASGTNSSKSIEDVRPLLGDIKKKAVERIRDYLVSQIRALRSPNINAQIIQQQRLVKFKDLYGYISRAHPTLTGEITQAYINTMRWYYLSHFTRYHQALEKIKVYPSDRNEVLGGDPSSHKTGNIVPGGRAGSAAHDPFSLGRRVDILRAGNQMAISSYLAEEDNAFHGLEVPFRNFNLALLDNVSAEYSFMTEMFSTLGFQQISRKAVEIFEPVFTLGQALTKHLIEQTTDALGVLICVRLNQQAAFELQRRKVPVADSYVNGTNMQLWPRFQVIMDTQCESLKRVAANTGRSAVSALSLAGGDDLNKSSAPHFLTQRFGQLLHGILVLSSEAGDDEPVANSLGRLTTEFDNLLAKLSRIGGDAKRRERFLYNNYSLVLAIISDTHGKLATEQKQVIGAGVVGLAVARQLAMKEGTSTILLERHDAPGTETSSRNSEVIHAGLYYGADTLKTSLCIKGKELLYALCAQHNIPHRNTKKWIVAQTPEQWEACLRVHEHAKRIGVPTRILGQEEAQRREPEVRALAGIVESPTTGIIDSHSLMTYLQGDFEDRGGDCAFMTQVTGIEPLPASEGGGYRISAVSADGSETTITAETVINSAGNGACAINNMVMPAERHRKAYFAKGTYFSYSASTPKTSVLVYPTTLPGTGGLGTHLTLDMGGRIRFGPDVEWVEDPSDLRPSPARLQQALPEIRAYLPNVDVEAIALDYCGIRPKLGKGGAVNTGKGFQDFVIQEEEGFPGFVNLLGIESPGLTSCLAIGERVRDILYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3K4</accession>
    <name>A0A8G1R3K4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-glucuronidase</fullName>
            <ecNumber evidence="2">3.2.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_513137</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.31" evidence="2"/>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516746.1">
        <property type="nucleotide sequence ID" value="XM_025664691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3K4"/>
    <dbReference type="GeneID" id="37168093"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004566">
        <property type="term" value="F:beta-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019391">
        <property type="term" value="P:glucuronoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001198">
        <property type="entry name" value="Beta-glucuronidase UidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000080">
        <property type="entry name" value="Beta-glucuronidase UidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007538">
        <property type="entry name" value="PRK10150.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10066">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10066:SF67">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="9">
        <location>
            <begin position="14"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="7">
        <location>
            <begin position="183"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="8">
        <location>
            <begin position="278"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH58824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="594" mass="66623" checksum="D324DDDD01FCE049" modified="2022-01-19" version="1">MLKPQQTPFRDIVSLDGLWKFALGSSGNETAAPWTAPLATNLECPVPASYNDIFVDRQIHDHVGWVYYQREAIVPSGWSHQQYLVRVEAATHHGRIYINDHLVAEHVGGYTPFEADITGLVSAGISFRLTIAVSNVLTHEVIPPGRIEVEEFTGKITQVYQHDFFNYAGLARSVSLYSVPKQHIQDIRVITNVDGTTGLIDYLVTVSNSTTERIKIKVVDEDGRTVTEASGTRGTATIDSARLWHPGDAYLYQFQVSIVGSDDSIIDTYSVATGVRTVKVSGNQFLINDKPFYFTGFGKHEDSNVRGKGYDPAYMVHDFQLMNWMGANSFRTSHYPYAEEVMEFADRHGIVVIDETPAVGLSYSIGAGQSSEDSQQTFTPEGINNKTREAHKQAIWELIARDKNHASVVMWSIANEPASHEAGAREYFAPLVDLAHELDSTRPVCFTNYGDATYELDRISDMFNVLCLNRYFGWYTQTGEIEEAEAALEKELLGWEGKYDKPIVMTEYGADTIAGLHSVLGLPWSEEFQVELLDMYHRVFDRVESVVGEQVWNFADFQAAVGVSRVDGNKKGIFTRDRKPKAAAQALRKRWRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3L5</accession>
    <name>A0A8G1R3L5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_282027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516761.1">
        <property type="nucleotide sequence ID" value="XM_025655208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3L5"/>
    <dbReference type="GeneID" id="37158610"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH58839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="160" mass="18165" checksum="741D547135DB306B" modified="2022-01-19" version="1">MSYYPAYIIRTHLAIPNPDLPSPRYHTAIFVETDPVTGSGTIHEVTGDITSPEGMHYETKLVARPESDENFYSRTLLGMTNAAIYPDSWDKVLRELPAPPQRKAFNIKRMKTEPFKRLSPLEFYEDGEERRPLVKCTEWVADKAIPALRKAGLLQSSISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R3P5</accession>
    <name>A0A8G1R3P5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cpn10-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO85DRAFT_520384</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FIP1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515596.1">
        <property type="nucleotide sequence ID" value="XM_025665132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R3P5"/>
    <dbReference type="GeneID" id="37168534"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="10">
        <location>
            <begin position="156"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAH57674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="442" mass="47282" checksum="EA70BF14A693C33F" modified="2022-01-19" version="1">MMMEDEDDDFYDPADAVPVTQHQNGSQHPPADSGPQDSNDAEEEEIEVEEDEDDFNIITEAPADAPPPEVPHPRHASLRAESQRPSSSADVSTISKSITPTVTPKLESVTPVPAAARPAVPQKPGSAYPPVHASNIDVHANPVHPATGKPIMLTDMDTDFPEDDKPWRRPGSDITDYFNYGFDEFTWASYVLKQQELRKEIGDQKKQLDDMQAFLSMGLPPMPGGPPGPGGPPGSAPPPMPGMPGMPDMSQEMMQGMLTSMMSQGLDPSSMDPMAFMQHAQAMMGGQPGAGGGQQGQPGFGGQGGGQPQMGYGGGFGRGRGRRCVIVAHHQAPGPSTLNLSFLRNVKSLAPLLDRVLVQRVKPEAKTASGIFLPESSVKEQNEAKVLAVGPGVFDKNGQRLPMSVAPGDRVLIPQFGGSAVKVGEDEYTLFRDHEILAKIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4L7</accession>
    <name>A0A8G1R4L7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Salicylate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_458281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517009.1">
        <property type="nucleotide sequence ID" value="XM_025661572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4L7"/>
    <dbReference type="GeneID" id="37164974"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="1">
        <location>
            <begin position="181"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="428" mass="46484" checksum="4CB08CCE338381A5" modified="2022-01-19" version="1">MTRTQKQITLARATRPLETTVALVAHYSKGSYYIFENNEIWYIGLGIYASLTFDAQGQTATMTGSDGQSESTAITGSTTDLTREFVSEYSSHGKIFGQVGSNYSARCSGQAFESGQWPMLNIIVPSVGVIIERNKVTITGDDDEDILQVSEKIESVLEAELAEDIALSSPVEGKINLNVDAQTYQTRVANAIADNSEAKYTKAIPSRKVPIDFRVNMLATLLHGRRANNPARTFSFNHNGIQATGFSPEVLLSINGDKAYTEALAGTQLSHLAKASLDPFNNKLHDDIKEVAEHVIAIKGSIRRLSKLCELESIAIKDFMKVMPRGSVQHLYSHVCGNLKPGCDGRDALPGLIANITVPGLPGDGNSDAMNSFESDPRDLYCGADESRQWLQAGAGVTINSKPEREYDETCEKLGSVAPFVVPASNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4Q7</accession>
    <name>A0A8G1R4Q7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO85DRAFT_368751</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517160.1">
        <property type="nucleotide sequence ID" value="XM_025655880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4Q7"/>
    <dbReference type="GeneID" id="37159282"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="17"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAH59238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="397" mass="44742" checksum="E7BA3F31EA2FFF07" modified="2022-01-19" version="1">MALAYSKVPSGTTVIPSPFQVHVSDEQIEELQLLVKLSKLAPPTYEGLQQDRKYGITNEWLANAKEAWKSLDWRSAESRINSFPQFTYDIEGLTIHFVALFSERKDAIPIVLLHGWPGKLTFLEFLPALDSIRDKYSPETLPYHIVIPSLPGFTFSSGPPLDVNFTGIDTARVINKVMLNLGFEDGYVAQGGDIGSRIGRILAVDHESCKAVHLNACYMGKPCNVPDTAITEEDKRALARAQWFGTYGSGYAVEHGTRPSTIGNVLSTNPVALLAWIGEKFLDWADEAIPLETILESVSLYWFTETFPRSIYHYRENVPPPKLRQAEDPRWYIRKPFGFSYYPKELVPTPRAWVETTGNLVFWQAHEKGGHFAALERPQDFLDDLTAFCGQVWAGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R4U9</accession>
    <name>A0A8G1R4U9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calpain-like protease PalBory</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_519197</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family. PalB/RIM13 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516211.1">
        <property type="nucleotide sequence ID" value="XM_025665029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R4U9"/>
    <dbReference type="GeneID" id="37168431"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02656">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25435">
        <property type="entry name" value="PalB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="6">
        <location>
            <begin position="118"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH58289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="857" mass="95273" checksum="31AC531E269387E1" modified="2022-01-19" version="1">MSRPNAASTKFLVNQALKAERDASSAITQGQALESAIDAAENYMKALSLTTESKDRQALDAKCKEWLTRAEKIKQNKDWQAVVQIQGKSGLTARFPKSTRKLTTREEIILLESAKLNGFIFPPWKNAPGPEDFEKGVEGLFTDKPDLHLSKQQRRILAGWERPSELLSKHANGIHGLRSGMPVMSVSGTTDLVQDMLTDCSVVASLCAATSRSERGLDKHHLPIVFPCEYGQVNPIISPSGKHIFRFYFNGCFRKVVIDDRLPASKTTRSLHVVDRNNPNFLWPAFVEKAYLKLRGGYDFPGSNSGTDLWVLTGWIPEQVFLHQDDVTAEQLWRRLFKRFRHGDVLLTIGTGKLTEREQKELGLASEHDYAILDMREQRDRRQMLVKNPWAGDDATTGDIADSFGLGHTSHTPASSLPRTYWMDCESVLQNFENLYLNWNPGIFRYREDIHFTWDLSTARGVAGCFAKNPQFAVTSEIGGNVWLLLGKHFRSIHHDEQNQVPQDDLEPGFISIYVFNANGKRVALSEGALHRGPYVDSPNTLMRLEMPPGTTYTVAVSEQSLPAVSQNFTLSALSDNPLLLAPAQNRYACLTKTQGMWMPSTAGGNAESARYPLNPQFRLEVHDDTDISILLEPSEPELATHVKLFWSNGQRVTRVRNRDIITDSGDYRRGGSLAEKKRLGAGVYTLVCSTFAPDQLGRFTLWISSALPCDVKPLAPEAAGRRAVISDIGVLTPGKDRMLASLETNRLTRIKLIGRSRMSTIGNRAVGPSPMLMTVELGQGPYKEILATSEDGNHSDAISGVRIEDFDLHPGLADQGGAWIVIERIGGPGGQVEDHFEVEALAEERVDIGEWIVEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R503</accession>
    <name>A0A8G1R503_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_245871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517511.1">
        <property type="nucleotide sequence ID" value="XM_025654885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R503"/>
    <dbReference type="GeneID" id="37158287"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="622" mass="68867" checksum="230CFABA48E76C57" modified="2022-01-19" version="1">MLDELERTFDEHPSLDASLEDFESNSNARQSPVFGLPSQHSGFRSEESDGEDDDLTPNGDRWSPPGLRRYDYVQGSGWYRHQPYVRNPDYDRFCLKPSVGLSPSQSREPSPQYEDALEAPTAGKRSQSAETADITIAANVPLPADAETPEKGRSPSPGPKGARASPDGEGLDFGSGNNLSNYIRFAVRAEVQHREPFVAFFSYLRSKLDKITSSKSNAILSVIVAFISIAFMRALFLPSVPEAIPDLVKLSGFARSFEPLIYYSENGAHQITALQETGVAVWDLGESVRGTNMTSAPIIVRQLDELSESLKSLSLELARFFSDVEGDIDSILLAMDWAKRELEALSSQPPSTFPSVVFDNLHGIFARLGALERLSAASGEGSSTELTSTPTTFGNFVTAVFGQTSAQRTRTTLTRTFTEMLSVLEEAINNELTHSTALFALFEAIDRQFLNLQRTVVRESDVQEREEGEMLESLWTRIMGANAAAIRKYEKNKRLLANVRSRTVTNKHLLVDHRGRLLTLKVNLETLRRKLVSPLVRRNDSMSFTGIESSSRSNGRMLGHVEAVIDGQIRGLEGSYDYLKSVRDKQKAKTLEFYYGFGRRLPQNPVLADGSDDLGTDAIDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5H5</accession>
    <name>A0A8G1R5H5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Urease accessory protein UreG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO85DRAFT_447453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517489.1">
        <property type="nucleotide sequence ID" value="XM_025659725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5H5"/>
    <dbReference type="GeneID" id="37163127"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05540">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000208">
        <property type="entry name" value="Urease accessory protein UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715:SF0">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="7">
        <location>
            <begin position="53"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAH59567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="271" mass="29077" checksum="3ED718D545DACBAD" modified="2022-01-19" version="1">MSHSHSHDNDVSHSHDDFGGHGHSHEILDGPGSYINREMPLSEERDWKDRAFTIGIGGPVGSGKTALMLALCQALRDEYNIAAVTNDIFTREDAEFLTRHKALSPSRIRAIETGGCPHAAVREDISANLLALQSLHRQFQTDLLLIESGGDNLAANYSRELADFIIYVIDVAGGDKVPRKGGPGITGSDLLVVNKIDLAEAVGADLAVMERDAAKMREGGPTVFAVVKSGTRVQDIVNLILSAWKASGAYEHSLARWKAGAKRGSGSVDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5K8</accession>
    <name>A0A8G1R5K8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO85DRAFT_436904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517905.1">
        <property type="nucleotide sequence ID" value="XM_025658592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5K8"/>
    <dbReference type="GeneID" id="37161994"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAH59983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="134" mass="14715" checksum="9F3602267C992544" modified="2022-01-19" version="1">MFQIHSFLSRRGDPRDAAVAGSLVGLILIQGPTEYHGCCWWRFLVFPLFGVRRPDVNVSCVVHVLSGLVLSQGYRRKSPQISSSSVGGRYSVGGSSSPLPRVVVVQSLEYIHRAQMYAVRKASRTKQDIALALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5R5</accession>
    <name>A0A8G1R5R5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ebp2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_396006</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825060">
        <property type="protein sequence ID" value="RAH58739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025516661.1">
        <property type="nucleotide sequence ID" value="XM_025656982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5R5"/>
    <dbReference type="GeneID" id="37160384"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH58739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="369" mass="41188" checksum="B9903070685538D3" modified="2022-01-19" version="1">MPKRSKLLQALDEHRGRDYEAEKQKKLVKAAKKKNTSTKGDDVKESVVEEKKEKKKEEEEEVSEQSEEEETPDAEEPSENEEEEEDDDDEDEEEEESDIPLSDLEDDEREDVVTHQRLTINNSAAITSSLKRISFLTPATPFSEHNSLVSQEPIEVPDANDDLNRELAFYKVCQAAAMTARSMLKKEGVPFTRPGDYFAEMVKTDEHMGKIKKKLYDEAAAKKAAAEARKQRDLKKFGKQVQVAKLQQRAKEKRETLEKINALKKKRKADTGGPTDDSSNMFDVAIDDAAQAGGGRKRGRDAEGGPSMKRQKKNEKFGFGGKKRFSKSGDAVSSGDMRDFSVKKMKGGPKGGGAKRPGKSRRAAAKGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R5Y6</accession>
    <name>A0A8G1R5Y6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetate hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO85DRAFT_447272</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 112811</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518623.1">
        <property type="nucleotide sequence ID" value="XM_025659686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R5Y6"/>
    <dbReference type="GeneID" id="37163088"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="11"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAH60701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="232" mass="25787" checksum="1BB9734A5B7E7255" modified="2022-01-19" version="1">MASAIRANCRKVICIGRNYADHITELNNTKPKQPFFFLKPASAILCPGEGPVLRPQGTNLHYEVELALVMGKTVRDLDPNDDKGALDAIHSYLLGIDMTARNVQEEAKKKGLPWTIAKGFDTFLPVSQEIAKSRLPDPHNAFLRLSVGSQMRQADSTGLMLYRIPRLLAEISRVMTLEKGDLVLTGTPKGVGQVKSGDVMKASIEYDGKELEEGRIEVEVKDREGRYRYSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R634</accession>
    <name>A0A8G1R634_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO85DRAFT_262687</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homopentamer. Forms homooligomers. Interacts with MFM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825059">
        <property type="protein sequence ID" value="RAH59172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517094.1">
        <property type="nucleotide sequence ID" value="XM_025655035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R634"/>
    <dbReference type="GeneID" id="37158437"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000005">
        <property type="entry name" value="Inner membrane magnesium transporter MRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAH59172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="573" mass="63009" checksum="B3E39575775354AA" modified="2022-01-19" version="1">MLSPSSMKPSAPSASLLRFLRSQSDSFFFTANPATCGRSLNNDPQSHHQHHAFSLSRTSDWTSINPAPCRASLESCLFPLPGLSSRTRGTTVRCRASLAQRSSPSPFSLPNAQFSRASSTKSKSLWRRLFDFKRNKTAESKSYLRQPPALINDGTEGSFNIGRGLVAKASNEPRLRCTEFDSTGNVTLVNGEFKKSELIAKYGLLPRDLRKIDSSTLPHILVRPRAILINLLHLRVLIKADRVLVFDAYGSTDSYMQSLFVYDLEGKLQQKQGQTTGALPYEFRALEAVLISVTSGLEEEFNGVRDPVVSVLRALEEDIDRDKLRHLLIYSKKLGTFEQKARLVRDAIDDLLEADDDLAAMYLTENSQGVRREEHEHQEVEMLLESYHKVCDEIVQASGNLVTGIRNTEEVVKAILDANRNSLMLLDLKFSIGTLGLATGTLFSALYGMNLKNFIEESDLGFGAVSVTCFAITIVVCAYGLAKLRKLQRVRMWGESGVGGASMVSLPTRGGALASHRPNWRADTVEPVWGSLPGEGRVERIKRIKDNAAAAAARSATLKAANVPPTTSSGDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6A1</accession>
    <name>A0A8G1R6A1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HRQ family protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_391935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518265.1">
        <property type="nucleotide sequence ID" value="XM_025656828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6A1"/>
    <dbReference type="GeneID" id="37160230"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="417" mass="47884" checksum="7076677193C83387" modified="2022-01-19" version="1">MNMNIIEDWIFYIQNNPIVVVFLVLALWLFGLWNRRSPNTIPKDEVSKEEQDTYPPVTPLPSFNWETTEPTKYRPFKPKYHLSMALTTTDISHLIPMDKTYKERLTLRQSLLTQYPTIVVGVTPAGQKPESPVHAAITELYEFIVGVYLPTRYPSMFTLETTTHTRSQDNTNTNNKECTNKTLLNKITNTRIPLPHRGSGRDMLSTLGTFVDEDFLVLLPESSSSSSSLSPTEEKEKEEQEEKKYTLEAYTTFYPAGFDTREKLGKRLSTIHDPVPRYKERLEKSMDRFFARLEVGKVVQRVNWSINTKGTGLFAAFGGLHGHEGEKRERVLGVEEVDGEGTLFRCERQTLHRLPKTKALVFTFHTYTYPIREIKEEGLGEELAMAIDGLKEGNVPEIHRYKRGPVWGEAVKAYLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6B6</accession>
    <name>A0A8G1R6B6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_520322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825062">
        <property type="protein sequence ID" value="RAH57595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025515517.1">
        <property type="nucleotide sequence ID" value="XM_025665126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6B6"/>
    <dbReference type="GeneID" id="37168528"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH57595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="42437" checksum="EAF3C18914ED9E31" modified="2022-01-19" version="1">MTPRRSSKRVGRPRLDTTATTTNSTAILSPNRRTQVRRAQRTYRLKKEAVFRNAIDRAEQLEARFRIVREEVAGLLADVATEEHQLHPTIQTRLKRLHEILLSDDGDDTPVATSTDNTTSLPSSSSSSTEPDPSPSAHHHHHQQPTYPNNHHPLTHNQPLTFLPPPLPTKHHTYAFHEPRFMRKLHRYTLEHAYRLFTDPRSNPSTIYRVFRLVPCIRDPQKTQPRFQQLLTGGCTDPLEVPGLPFYGIGGAGTHFRGVDGDVPQNRRMPGRVLGVMSSSSSKSRDDMLEMYGLGGTWFDCRDVEGFLGLMGVDITHGGMFLRCSGVGDAVGEYVLDVEGFFSRLLPGLVILGRTPGFREVDVRRALQGSVRRVDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6G1</accession>
    <name>A0A8G1R6G1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nonribosomal peptide synthase Pes1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO85DRAFT_446120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 112811</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH60971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518893.1">
        <property type="nucleotide sequence ID" value="XM_025659431.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37162833"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904091">
        <property type="term" value="F:non-ribosomal peptide synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19534">
        <property type="entry name" value="E_NRPS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000024">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000026">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000016">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000017">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000031">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000037">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000002">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000010">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398:SF1">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="789"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="3383"/>
            <end position="3459"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="4481"/>
            <end position="4557"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="5554"/>
            <end position="5630"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="6138"/>
            <end position="6216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="5537"/>
            <end position="5558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAH60971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="6269" mass="697610" checksum="21B9E52674A0A7EC" modified="2022-01-19" version="1">[encoded data, 6269 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6I2</accession>
    <name>A0A8G1R6I2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO85DRAFT_435325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 112811</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ825056">
        <property type="protein sequence ID" value="RAH61001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518923.1">
        <property type="nucleotide sequence ID" value="XM_025658518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6I2"/>
    <dbReference type="GeneID" id="37161920"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAH61001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="292" mass="32390" checksum="D103D43A6DADDD9C" modified="2022-01-19" version="1">MSKYGVLVMGPAGAGKTTFCSSIIQHLQNTRRSCFYVNLDPAAETFNYEPDLDIRELITLEDVMEELGLGPNGGLIYCFEFLLQNLEFLSEALDPLSEEYLIIFDMPGQIELYTHIPLLPSLVQFLSRQGPLNISLCAAYLLESTFVVDKAKFFAGTLSAMSAMLMLEMPHVNILSKMDQVKDMVSRKELKQFTNVDVNNLLGTAGDDEESSVVTGDPSSKDAMLSGGSFQQLNRAVGQLIDDFSMVSFLKLDVQDEDSVAAVLSHIDDAIQYHEAQEPREPSDAQEVDYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R6R0</accession>
    <name>A0A8G1R6R0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_233053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518520.1">
        <property type="nucleotide sequence ID" value="XM_025654788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R6R0"/>
    <dbReference type="GeneID" id="37158190"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH60598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="134" mass="14992" checksum="89459B99A132DF79" modified="2022-01-19" version="1">MGILPLDFSFHDGIATTSCDEVYSCLFGSTFGQYFRLRALLPLSSASSCPFPFPLSPFFLFYLTFYNSVYMALNILVSARARGSVARASERTIEFGLLELCSGLENGCEWRFPSSTLMSANLLILQHEVFMAWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7B5</accession>
    <name>A0A8G1R7B5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO85DRAFT_251232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825058">
        <property type="protein sequence ID" value="RAH59832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025517754.1">
        <property type="nucleotide sequence ID" value="XM_025654933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7B5"/>
    <dbReference type="GeneID" id="37158335"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAH59832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="107" mass="12285" checksum="570859BAF5A7C0F9" modified="2022-01-19" version="1">MWGILKRYPENSFDGIRLILHPNGANVDKEQRRVDHARNPLQSSVLLPLPMLDDPSYAYCIHYNPPWANFATGNPKIREREPRGTHGTDSKGRNARLIYCVDARCLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7I2</accession>
    <name>A0A8G1R7I2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Morphogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO85DRAFT_485866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 112811</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ825057">
        <property type="protein sequence ID" value="RAH60738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025518660.1">
        <property type="nucleotide sequence ID" value="XM_025663344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8G1R7I2"/>
    <dbReference type="GeneID" id="37166746"/>
    <dbReference type="Proteomes" id="UP000249526">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04401">
        <property type="entry name" value="RhoGAP_fMSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037508">
        <property type="entry name" value="Msb1/Mug8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012965">
        <property type="entry name" value="Msb1/Mug8_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093:SF1">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08101">
        <property type="entry name" value="Msb1-Mug8_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotically up-regulated protein Msb1/Mug8" evidence="2">
        <location>
            <begin position="43"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="677"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="956"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAH60738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000249526"/>
        </source>
    </evidence>
    <sequence length="1013" mass="110686" checksum="F72B3D5FC6696BDD" modified="2022-01-19" version="1">MPFFTRVFRSKDNNAAKKAAKSPEVEEKGPAKPTWTDAWQRSEVAPEEVQELLRGCTQELKARALQTPFLLLPFRPSTDASAARTFIRNYFNQSLERGSPLSGDALAQELRLSDPMVLCSVLKWCWSRLPGGVVTWEAYELFKVGEQDSQFAPDAFTTFIPISVDSDARSKIVFDFFDLLAAVAAHGKSNGLGGRKLSRYAGWWAFDHADTGNGFEAAYKNWARAADATSHLFFAYLRSLSPELRGVNAITTLPISLQTLVRATEYPPETPTLLQVSTTRVVMIVDTVSPTPFALLRRAKNFEYRDSDSHLQEFASFEEPTKALTDECLRVLKCISSINQSSAPEPGSATREASWSRFEDLGFGGALESDLDDDSSAVRLARNEFGGGLRSAPQSGAGDFGRPTTPSWADFMSSGFGDENGLKGPIAPLLLPPDKVLPPIASVRGQSSQSHKRSLNDEPSMEPGELASITTLDLDDSFWWVWISSLAGEEPVSRKAVFGRCALLETVIKDTKWLVLEEQVKGAAPEPEPGAYIVEKKRFFGFSTRKRGVGRRKSSAKKVSAVEDSYKRPDNEAPQSKTSIAPDQHARIQAAAAALQKRHREEQEAANGSKNVSEDVKYNTKTNSVMTLQPSIVNEASQAMKWATNYDKNTYRTAYLSNSRAGTGALAEDAKVPIEQPSTPTSPKASPSARQAPPPLPKDTPSSSPKPAVPRKEPAAQEEHPASRADSPSLALSTTESLPKQSMDSEESSRKIKKKPGNAGFKSMFGTVKKKNEPEPKPPMKPTGSAVAAARAALEDKARAAQEQTMRPSTNGKPTLKKKPVPITVPVEAPKPVESPKPAEPAAEEKAPEPTEPTVSMDALKPPVPHSDEPQIRRQAEYDALSRIDTRERAAADQEFSRFDQGPLVEQPAFVPSDSPVSERFPEKPASFHSATDRVSVEPQDERSPSPPPMNTSFDRWAQIRQNAAARAAQVESHADDSDDDNTSEEESFESRAARIKARVAELTGNMQAASKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8G1R7K2</accession>
    <name>A0A8G1R7K2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Extracellular exo-inulinase inuE</fullName>
            <ecNumber evidence="12">3.2.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO85DRAFT_458371</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus piperis CBS 112811</name>
        <dbReference type="NCBI Taxonomy" id="1448313"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/
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